High-Resolution Spectroscopic Database for the NASA Earth Observing System Program

NASA Technical Reports Server (NTRS)

Rothman, Laurence

2003-01-01

The purpose of this project is to develop and enhance the HITRAN molecular spectroscopic database and associated software to support the observational programs of the Earth Observing System (EOS). In particular, the focus is on the EOS projects: the Atmospheric Infrared Sounder (AIRS), the High-Resolution Dynamics Limb Sounder (HIRDLS), Measurements of Pollution in the Troposphere (MOPITT), the Tropospheric Emission Spectrometer (TES), and the Stratospheric Aerosol and Gas Experiment (SAGE III). The HITRAN program is also involved in the Ozone Monitoring Experiment (OMI). The data requirements of these programs in terms of spectroscopy are varied with respect to constituents being observed, required remote-sensing parameters, and spectral coverage. A general requisite is for additional spectral parameters and improvements to existing molecular bands sufficient for the simulation of the observations leading to retrieval of the atmospheric state. In addition, cross-section data for heavier molecular species must be expanded and made amenable to modeling in remote sensing. The effort in the project also includes developing software and distribution to make access, manipulation, and use of HITRAN functional to the EOS program.

High Resolution Spectroscopic Database for the NASA Earth Observing System Program

NASA Technical Reports Server (NTRS)

Rothman, Laurence

2004-01-01

The purpose of this project has been to develop and enhance the HITRAN molecular spectroscopic database and associated software to support the observational programs of the Earth Observing System (EOS). Emphasis has been on the EOS projects: the Atmospheric Infrared Sounder (AIRS), the High-Resolution Dynamics Limb Sounder (HIRDLS), Measurements of Pollution in the Troposphere (MOPITT), the Tropospheric Emission Spectrometer (TES), and the Stratospheric Aerosol and Gas Experiment (SAGE III). The HITRAN program is also involved in the Ozone Monitoring Experiment (OMI). The data requirements of these programs in terms of spectroscopy are varied with respect to constituents being observed, required remote-sensing parameters, and spectral coverage. A general requisite is for additional spectral parameters and improvements to existing molecular bands sufficient for the simulation of the observations leading to retrieval of the atmospheric state. In addition, cross-section data for heavier molecular species must be expanded and made amenable to modeling in remote sensing. The effort in the project also includes developing software and distribution to make access, manipulation, and use of HITRAN functional to the EOS program.

High-Resolution Spectroscopic Database for the NASA Earth Observing System Program

NASA Technical Reports Server (NTRS)

Rothman, Laurence S.

2004-01-01

The purpose of this project is to develop and enhance the HITRAN molecular spectroscopic database and associated - software to support the observational programs of the Earth observing System (EOS). In particular, the focus is on the EOS projects: the Atmospheric Infrared Sounder (AIRS), the High-Resolution Dynamics Limb Sounder (HIRDLS), Measurements of Pollution in the Troposphere (MOPITT), the Tropospheric Emission Spectrometer (TES), and the Stratospheric Aerosol and Gas Experiment (SAGE III). The HITRAN program is also involved in the Ozone Monitoring Experiment (OMI). The data requirements of these programs in terms of spectroscopy are varied with respect to constituents being observed, required remote-sensing parameters, and spectral coverage. A general requisite is for additional spectral parameters and improvements to existing molecular bands sufficient for the simulation of the observations leading to retrieval of the atmospheric state. In addition cross-section data for heavier molecular species must be expanded and made amenable to modeling in remote sensing. The effort in the project also includes developing software and distribution to make access, manipulation, and use HITRAN functional to the EOS program.

A high time resolution x-ray diagnostic on the Madison Symmetric Torus

NASA Astrophysics Data System (ADS)

DuBois, Ami M.; Lee, John David; Almagri, Abdulgadar F.

2015-07-01

A new high time resolution x-ray detector has been installed on the Madison Symmetric Torus (MST) to make measurements around sawtooth events. The detector system is comprised of a silicon avalanche photodiode, a 20 ns Gaussian shaping amplifier, and a 500 MHz digitizer with 14-bit sampling resolution. The fast shaping time diminishes the need to restrict the amount of x-ray flux reaching the detector, limiting the system dead-time. With a much higher time resolution than systems currently in use in high temperature plasma physics experiments, this new detector has the versatility to be used in a variety of discharges with varying flux and the ability to study dynamics on both slow and fast time scales. This paper discusses the new fast x-ray detector recently installed on MST and the improved time resolution capabilities compared to the existing soft and hard x-ray diagnostics. In addition to the detector hardware, improvements to the detector calibration and x-ray pulse identification software, such as additional fitting parameters and a more sophisticated fitting routine are discussed. Finally, initial data taken in both high confinement and standard reversed-field pinch plasma discharges are compared.

Brain Atlas Fusion from High-Thickness Diagnostic Magnetic Resonance Images by Learning-Based Super-Resolution

PubMed Central

Zhang, Jinpeng; Zhang, Lichi; Xiang, Lei; Shao, Yeqin; Wu, Guorong; Zhou, Xiaodong; Shen, Dinggang; Wang, Qian

2017-01-01

It is fundamentally important to fuse the brain atlas from magnetic resonance (MR) images for many imaging-based studies. Most existing works focus on fusing the atlases from high-quality MR images. However, for low-quality diagnostic images (i.e., with high inter-slice thickness), the problem of atlas fusion has not been addressed yet. In this paper, we intend to fuse the brain atlas from the high-thickness diagnostic MR images that are prevalent for clinical routines. The main idea of our works is to extend the conventional groupwise registration by incorporating a novel super-resolution strategy. The contribution of the proposed super-resolution framework is two-fold. First, each high-thickness subject image is reconstructed to be isotropic by the patch-based sparsity learning. Then, the reconstructed isotropic image is enhanced for better quality through the random-forest-based regression model. In this way, the images obtained by the super-resolution strategy can be fused together by applying the groupwise registration method to construct the required atlas. Our experiments have shown that the proposed framework can effectively solve the problem of atlas fusion from the low-quality brain MR images. PMID:29062159

Brain Atlas Fusion from High-Thickness Diagnostic Magnetic Resonance Images by Learning-Based Super-Resolution.

PubMed

Zhang, Jinpeng; Zhang, Lichi; Xiang, Lei; Shao, Yeqin; Wu, Guorong; Zhou, Xiaodong; Shen, Dinggang; Wang, Qian

2017-03-01

It is fundamentally important to fuse the brain atlas from magnetic resonance (MR) images for many imaging-based studies. Most existing works focus on fusing the atlases from high-quality MR images. However, for low-quality diagnostic images (i.e., with high inter-slice thickness), the problem of atlas fusion has not been addressed yet. In this paper, we intend to fuse the brain atlas from the high-thickness diagnostic MR images that are prevalent for clinical routines. The main idea of our works is to extend the conventional groupwise registration by incorporating a novel super-resolution strategy. The contribution of the proposed super-resolution framework is two-fold. First, each high-thickness subject image is reconstructed to be isotropic by the patch-based sparsity learning. Then, the reconstructed isotropic image is enhanced for better quality through the random-forest-based regression model. In this way, the images obtained by the super-resolution strategy can be fused together by applying the groupwise registration method to construct the required atlas. Our experiments have shown that the proposed framework can effectively solve the problem of atlas fusion from the low-quality brain MR images.

Preliminary evaluation of a high-resolution workstation for diagnostic interpretation of portable radiographs

NASA Astrophysics Data System (ADS)

Honeyman-Buck, Janice C.; Huda, Walter; Palmer, Carole K.; Frost, Meryll M.; Moser, Robert; Staab, Edward V.

1995-04-01

A cost effectiveness study on the feasibility of using computed radiography (CR) instead of screen-film methods for portable radiographs indicates that we could only justify CR if film were eliminated. Before purchasing CR equipment, we needed to evaluate the use of softcopy to replace film for routine clinical use. The evaluation had to cover image quality, human factors, and efficiency measures. Screen-film radiographs were digitized and used to simulate CR in two studies. The first study evaluated the quality of digitized images and the workstation user interface. Twenty-one radiographs were selected at random from scopes in the radiology department, were digitized, and transferred to a megascan workstation. Five radiologists were asked to assess the quality of the images and the ease of operation of the workstation while an observer recorded their comments and scores. The second study evaluated the feasibility of using the workstation in a clinical environment. Four radiologists read adult and pediatric portable images in film and softcopy format. Reports were evaluated for differences and timing statistics were kept. The results of the first study indicate that image quality may be acceptable for diagnostic purposes and suggests some changes in the user interface. Newborn infant images were the least acceptable in softcopy, largely due to magnification artifacts introduced when viewing very small images. The evaluation was based on a digitizer as a simulator for a CR unit and the digitizer did not exhibit the same resolution characteristics as CR. Films that were unacceptable from the digitizer are expected to be acceptable with CR. The results of the second study indicated that the high resolution diagnostic workstation could be used in a clinical setting, and that the diagnostic readings were not significantly different between film and softcopy displays. The results also indicated that, depending on the radiologist and the type of images, more time was

Radiofrequency field inhomogeneity compensation in high spatial resolution magnetic resonance spectroscopic imaging

NASA Astrophysics Data System (ADS)

Passeri, Alessandro; Mazzuca, Stefano; Del Bene, Veronica

2014-06-01

Clinical magnetic resonance spectroscopy imaging (MRSI) is a non-invasive functional technique, whose mathematical framework falls into the category of linear inverse problems. However, its use in medical diagnostics is hampered by two main problems, both linked to the Fourier-based technique usually implemented for spectra reconstruction: poor spatial resolution and severe blurring in the spatial localization of the reconstructed spectra. Moreover, the intrinsic ill-posedness of the MRSI problem might be worsened by (i) spatially dependent distortions of the static magnetic field (B0) distribution, as well as by (ii) inhomogeneity in the power deposition distribution of the radiofrequency magnetic field (B1). Among several alternative methods, slim (Spectral Localization by IMaging) and bslim (B0 compensated slim) are reconstruction algorithms in which a priori information concerning the spectroscopic target is introduced into the reconstruction kernel. Nonetheless, the influence of the B1 field, particularly when its operating wavelength is close to the size of the human organs being studied, continues to be disregarded. starslim (STAtic and Radiofrequency-compensated slim), an evolution of the slim and bslim methods, is therefore proposed, in which the transformation kernel also includes the B1 field inhomogeneity map, thus allowing almost complete 3D modelling of the MRSI problem. Moreover, an original method for the experimental determination of the B1 field inhomogeneity map specific to the target under evaluation is also included. The compensation capabilities of the proposed method have been tested and illustrated using synthetic raw data reproducing the human brain.

Determination of Spectroscopic Properties of Atmospheric Molecules from High Resolution Vacuum Ultraviolet Cross Section and Wavelength Measurements

NASA Technical Reports Server (NTRS)

Parkinson, W. H.; Yoshino, K.

1999-01-01

We have studied the spectroscopy and the cross sections of the simple molecules of atmospheric interest such as oxygen, nitric oxide, carbon dioxide, and water. We have made cross section measurements on an absolute base without the effects from the limited instrumental resolution. We have used the following different instruments- the grating spectrometer (6.65-m at CfA, 3-m at Photon Factory), VUV Fourier transform spectrometer at Imperial College, and then moved the same one to the Photon Factory. Selection of the instruments depend on the appearance of molecular bands, and their wavelength region. For example, the cross section measurements of Doppler limited bands can been done with the Fourier transform spectrometer at the very high resolution (0.025/ cm resolution). All of these spectroscopic measurements are needed for accurate calculations of the production of atomic oxygen penetration of solar radiation into the Earth's atmosphere, and photochemistry of minor molecules.

Active spectroscopic measurements using the ITER diagnostic system.

PubMed

Thomas, D M; Counsell, G; Johnson, D; Vasu, P; Zvonkov, A

2010-10-01

Active (beam-based) spectroscopic measurements are intended to provide a number of crucial parameters for the ITER device being built in Cadarache, France. These measurements include the determination of impurity ion temperatures, absolute densities, and velocity profiles, as well as the determination of the plasma current density profile. Because ITER will be the first experiment to study long timescale (∼1 h) fusion burn plasmas, of particular interest is the ability to study the profile of the thermalized helium ash resulting from the slowing down and confinement of the fusion alphas. These measurements will utilize both the 1 MeV heating neutral beams and a dedicated 100 keV hydrogen diagnostic neutral beam. A number of separate instruments are being designed and built by several of the ITER partners to meet the different spectroscopic measurement needs and to provide the maximum physics information. In this paper, we describe the planned measurements, the intended diagnostic ensemble, and we will discuss specific physics and engineering challenges for these measurements in ITER.

Hunting the parent of the Orphan stream. II. The first high-resolution spectroscopic study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Casey, Andrew R.; Keller, Stefan C.; Da Costa, Gary

2014-03-20

We present the first high-resolution spectroscopic study on the Orphan stream for five stream candidates, observed with the Magellan Inamori Kyocera Echelle spectrograph on the Magellan Clay telescope. The targets were selected from the low-resolution catalog of Casey et al.: three high-probability members, one medium, and one low-probability stream candidate were observed. Our analysis indicates that the low- and medium-probability targets are metal-rich field stars. The remaining three high-probability targets range over ∼1 dex in metallicity, and are chemically distinct compared to the other two targets and all standard stars: low [α/Fe] abundance ratios are observed, and lower limits aremore » ascertained for [Ba/Y], which sit well above the Milky Way trend. These chemical signatures demonstrate that the undiscovered parent system is unequivocally a dwarf spheroidal galaxy, consistent with dynamical constraints inferred from the stream width and arc. As such, we firmly exclude the proposed association between NGC 2419 and the Orphan stream. A wide range in metallicities adds to the similarities between the Orphan stream and Segue 1, although the low [α/Fe] abundance ratios in the Orphan stream are in tension with the high [α/Fe] values observed in Segue 1. Open questions remain before Segue 1 could possibly be claimed as the 'parent' of the Orphan stream. The parent system could well remain undiscovered in the southern sky.« less

Determination of Spectroscopic Properties of Atmospheric Molecules from High Resolution Vacuum Ultraviolet Cross Section and Wavelength Measurements

NASA Technical Reports Server (NTRS)

Parkinson, W. H.; Yoshino, K.

1997-01-01

An account is given of progress during the period 8/l/96-7/31/97 on work on (a) cross section measurements of O2 S-R using a Fourier transform spectrometer (FTS) at the Photon Factory in Japan; (b) the determination of the predissociation linewidths of the Schumann-Runge bands (S-R) of 02; (c) cross section measurements of 02 Herzberg bands using a Fourier transform spectrometer (FTS) at Imperial College; and (d) cross section measurements of H2O in the wavelength region 120-188 nm. The experimental investigations are effected at high resolution with a 6.65 m scanning spectrometer and with the Fourier transform spectrometer. Below 175 nm, synchrotron radiation is most suitable for cross section measurements in combination with spectrometers at the Photon Factory Japan. Cross section measurements of the Doppler limited bands depend on using the very high resolution, available with the Fourier transform spectrometer, (0.025/cm resolution). All of these spectroscopic measurements are needed for accurate calculations of the production of atomic oxygen, the penetration of solar radiation into the Earth's atmosphere, and photochemistry of minor molecules.

Spectroscopic photon localization microscopy: breaking the resolution limit of single molecule localization microscopy (Conference Presentation)

NASA Astrophysics Data System (ADS)

Dong, Biqin; Almassalha, Luay Matthew; Urban, Ben E.; Nguyen, The-Quyen; Khuon, Satya; Chew, Teng-Leong; Backman, Vadim; Sun, Cheng; Zhang, Hao F.

2017-02-01

Distinguishing minute differences in spectroscopic signatures is crucial for revealing the fluorescence heterogeneity among fluorophores to achieve a high molecular specificity. Here we report spectroscopic photon localization microscopy (SPLM), a newly developed far-field spectroscopic imaging technique, to achieve nanoscopic resolution based on the principle of single-molecule localization microscopy while simultaneously uncovering the inherent molecular spectroscopic information associated with each stochastic event (Dong et al., Nature Communications 2016, in press). In SPLM, by using a slit-less monochromator, both the zero-order and the first-order diffractions from a grating were recorded simultaneously by an electron multiplying charge-coupled device to reveal the spatial distribution and the associated emission spectra of individual stochastic radiation events, respectively. As a result, the origins of photon emissions from different molecules can be identified according to their spectral differences with sub-nm spectral resolution, even when the molecules are within close proximity. With the newly developed algorithms including background subtraction and spectral overlap unmixing, we established and tested a method which can significantly extend the fundamental spatial resolution limit of single molecule localization microscopy by molecular discrimination through spectral regression. Taking advantage of this unique capability, we demonstrated improvement in spatial resolution of PALM/STORM up to ten fold with selected fluorophores. This technique can be readily adopted by other research groups to greatly enhance the optical resolution of single molecule localization microscopy without the need to modify their existing staining methods and protocols. This new resolving capability can potentially provide new insights into biological phenomena and enable significant research progress to be made in the life sciences.

Propagation Diagnostic Simulations Using High-Resolution Equatorial Plasma Bubble Simulations

NASA Astrophysics Data System (ADS)

Rino, C. L.; Carrano, C. S.; Yokoyama, T.

2017-12-01

In a recent paper, under review, equatorial-plasma-bubble (EPB) simulations were used to conduct a comparative analysis of the EPB spectra characteristics with high-resolution in-situ measurements from the C/NOFS satellite. EPB realizations sampled in planes perpendicular to magnetic field lines provided well-defined EPB structure at altitudes penetrating both high and low-density regions. The average C/NOFS structure in highly disturbed regions showed nearly identical two-component inverse-power-law spectral characteristics as the measured EPB structure. This paper describes the results of PWE simulations using the same two-dimensional cross-field EPB realizations. New Irregularity Parameter Estimation (IPE) diagnostics, which are based on two-dimensional equivalent-phase-screen theory [A theory of scintillation for two-component power law irregularity spectra: Overview and numerical results, by Charles Carrano and Charles Rino, DOI: 10.1002/2015RS005903], have been successfully applied to extract two-component inverse-power-law parameters from measured intensity spectra. The EPB simulations [Low and Midlatitude Ionospheric Plasma DensityIrregularities and Their Effects on Geomagnetic Field, by Tatsuhiro Yokoyama and Claudia Stolle, DOI 10.1007/s11214-016-0295-7] have sufficient resolution to populate the structure scales (tens of km to hundreds of meters) that cause strong scintillation at GPS frequencies. The simulations provide an ideal geometry whereby the ramifications of varying structure along the propagation path can be investigated. It is well known path-integrated one-dimensional spectra increase the one-dimensional index by one. The relation requires decorrelation along the propagation path. Correlated structure would be interpreted as stochastic total-electron-content (TEC). The simulations are performed with unmodified structure. Because the EPB structure is confined to the central region of the sample planes, edge effects are minimized. Consequently

Factors Determining the Inter-observer Variability and Diagnostic Accuracy of High-resolution Manometry for Esophageal Motility Disorders.

PubMed

Kim, Ji Hyun; Kim, Sung Eun; Cho, Yu Kyung; Lim, Chul-Hyun; Park, Moo In; Hwang, Jin Won; Jang, Jae-Sik; Oh, Minkyung

2018-01-30

Although high-resolution manometry (HRM) has the advantage of visual intuitiveness, its diagnostic validity remains under debate. The aim of this study was to evaluate the diagnostic accuracy of HRM for esophageal motility disorders. Six staff members and 8 trainees were recruited for the study. In total, 40 patients enrolled in manometry studies at 3 institutes were selected. Captured images of 10 representative swallows and a single swallow in analyzing mode in both high-resolution pressure topography (HRPT) and conventional line tracing formats were provided with calculated metrics. Assessments of esophageal motility disorders showed fair agreement for HRPT and moderate agreement for conventional line tracing (κ = 0.40 and 0.58, respectively). With the HRPT format, the k value was higher in category A (esophagogastric junction [EGJ] relaxation abnormality) than in categories B (major body peristalsis abnormalities with intact EGJ relaxation) and C (minor body peristalsis abnormalities or normal body peristalsis with intact EGJ relaxation). The overall exact diagnostic accuracy for the HRPT format was 58.8% and rater's position was an independent factor for exact diagnostic accuracy. The diagnostic accuracy for major disorders was 63.4% with the HRPT format. The frequency of major discrepancies was higher for category B disorders than for category A disorders (38.4% vs 15.4%; P < 0.001). The interpreter's experience significantly affected the exact diagnostic accuracy of HRM for esophageal motility disorders. The diagnostic accuracy for major disorders was higher for achalasia than distal esophageal spasm and jackhammer esophagus.

High-resolution ground-based spectroscopy: where and how ?

NASA Astrophysics Data System (ADS)

Pallavicini, R.

2002-07-01

An overview is presented of high-resolution optical spectrographs in operation or under development at large telescopes, with emphasis on those facilities best suited for the study of late-type stars and stellar surface inhomogeneities. Plans for the development of new high-resolution spectroscopic instruments are discussed with emphasis on the ICE spectrograph for the PEPSI spectropolarimeter at the LBT.

FUor and EXor Variables, a NIR High-Resolution Spectroscopic Survey

NASA Astrophysics Data System (ADS)

Liskowsky, Joseph Paul

To better understand the labyrinth of heating and cooling processes in YSOs (young stellar objects), we study systems where there exists a large variability in the heating of this gas due to accretion. This research project focuses on several classes of early young eruptable T-Tauri stars, namely the FUors, the EXors and the so-called FU Ori-like, which all have the property of large amplitude oscillations in accretion rate. Each of these categories may well represent specific stages in early low-mass stellar evolution. While these objects have specific spectroscopic and circumstellar diagnostics (as means of identification) our research suggests that there are at least several objects that defy (typical) classification. The young objects ZCMa and L1551 IRS5 both show circumstellar diagnostics different from what is expected for an FUor (though ZCMa and L1551 are classified as such). In ZCMa we see an obvious accretion event, but the ro-vibrational overtone lines of CO are in emission. Typically, for an accreting FUor, these lines would be in absorption due to the physics of the disk. Very strangely, we see the fundamental lines in emission. Because of the relationship between the Einstein A coefficients for these transitions, we would expect to see either both the fundamental and overtone lines together in emission or absorption. This mystery may be solved by modeling and before we can make an intelligent claim about the heating mechanisms in YSOs, we need to understand these special cases first (it may turn out that these are not-so-special after-all and are indicative of a subclass of the FUor or EXor class).

Quality-control issues on high-resolution diagnostic monitors.

PubMed

Parr, L F; Anderson, A L; Glennon, B K; Fetherston, P

2001-06-01

Previous literature indicates a need for more data collection in the area of quality control of high-resolution diagnostic monitors. Throughout acceptance testing, which began in June 2000, stability of monitor calibration was analyzed. Although image quality on all monitors was found to be acceptable upon initial acceptance testing using VeriLUM software by Image Smiths, Inc (Germantown, MD), it was determined to be unacceptable during the clinical phase of acceptance testing. High-resolution monitors were evaluated for quality assurance on a weekly basis from installation through acceptance testing and beyond. During clinical utilization determination (CUD), monitor calibration was identified as a problem and the manufacturer returned and recalibrated all workstations. From that time through final acceptance testing, high-resolution monitor calibration and monitor failure rate remained a problem. The monitor vendor then returned to the site to address these areas. Monitor defocus was still noticeable and calibration checks were increased to three times per week. White and black level drift on medium-resolution monitors had been attributed to raster size settings. Measurements of white and black level at several different size settings were taken to determine the effect of size on white and black level settings. Black level remained steady with size change. White level appeared to increase by 2.0 cd/m2 for every 0.1 inches decrease in horizontal raster size. This was determined not to be the cause of the observed brightness drift. Frequency of calibration/testing is an issue in a clinical environment. The increased frequency required at our site cannot be sustained. The medical physics division cannot provide dedicated personnel to conduct the quality-assurance testing on all monitors at this interval due to other physics commitments throughout the hospital. Monitor access is also an issue due to radiologists' need to read images. Some workstations are in use 7 AM

CARMENES input catalogue of M dwarfs. III. Rotation and activity from high-resolution spectroscopic observations

NASA Astrophysics Data System (ADS)

Jeffers, S. V.; Schöfer, P.; Lamert, A.; Reiners, A.; Montes, D.; Caballero, J. A.; Cortés-Contreras, M.; Marvin, C. J.; Passegger, V. M.; Zechmeister, M.; Quirrenbach, A.; Alonso-Floriano, F. J.; Amado, P. J.; Bauer, F. F.; Casal, E.; Alonso, E. Diez; Herrero, E.; Morales, J. C.; Mundt, R.; Ribas, I.; Sarmiento, L. F.

2018-06-01

CARMENES is a spectrograph for radial velocity surveys of M dwarfs with the aim of detecting Earth-mass planets orbiting in the habitable zones of their host stars. To ensure an optimal use of the CARMENES guaranteed time observations, in this paper we investigate the correlation of activity and rotation for approximately 2200 M dwarfs, ranging in spectral type from M0.0 V to M9.0 V. We present new high-resolution spectroscopic observations with FEROS, CAFE, and HRS of approximately 500 M dwarfs. For each new observation, we determined its radial velocity and measured its Hα activity index and its rotation velocity. Additionally, we have multiple observations of many stars to investigate if there are any radial velocity variations due to multiplicity. The results of our survey confirm that early-M dwarfs are Hα inactive with low rotational velocities and that late-M dwarfs are Hα active with very high rotational velocities. The results of this high-resolution analysis comprise the most extensive catalogue of rotation and activity in M dwarfs currently available. Based on observations made at the Calar Alto Observatory, Spain, the European Southern Observatory, La Silla, Chile and McDonald Observatory, USA.Tables A.1-A.3 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/614/A76

Development of High-Resolution UV-VIS Diagnostics for Space Plasma Simulation

NASA Astrophysics Data System (ADS)

Taylor, Andrew; Batishchev, Oleg

2012-10-01

Non-invasive far-UV-VIS plasma emission allows remote diagnostics of plasma, which is particularly important for space application. Accurate vacuum tank space plasma simulations require monochromators with high spectral resolution (better than 0.01A) to capture important details of atomic and ionic lines, such as Ly-alpha, etc. We are building a new system based on the previous work [1], and will discuss the development of a spectrometry system that combines a single-pass vacuum far-UV-NIR spectrometer and a tunable Fabry-Perot etalon. [4pt] [1] O. Batishchev and J.L. Cambier, Experimental Study of the Mini-Helicon Thruster, Air Force Research Laboratory Report, AFRL-RZ-ED-TR-2009-0020, 2009.

Ultra-High Resolution Spectroscopic Remote Sensing: A Microscope on Planetary Atmospheres

NASA Technical Reports Server (NTRS)

Kostiuk, Theodor

2010-01-01

Remote sensing of planetary atmospheres is not complete without studies of all levels of the atmosphere, including the dense cloudy- and haze filled troposphere, relatively clear and important stratosphere and the upper atmosphere, which are the first levels to experience the effects of solar radiation. High-resolution spectroscopy can provide valuable information on these regions of the atmosphere. Ultra-high spectral resolution studies can directly measure atmospheric winds, composition, temperature and non-thermal phenomena, which describe the physics and chemistry of the atmosphere. Spectroscopy in the middle to long infrared wavelengths can also probe levels where dust of haze limit measurements at shorter wavelength or can provide ambiguous results on atmospheric species abundances or winds. A spectroscopic technique in the middle infrared wavelengths analogous to a radio receiver. infrared heterodyne spectroscopy [1], will be describe and used to illustrate the detailed study of atmospheric phenomena not readily possible with other methods. The heterodyne spectral resolution with resolving power greater than 1,000.000 measures the true line shapes of emission and absorption lines in planetary atmospheres. The information on the region of line formation is contained in the line shapes. The absolute frequency of the lines can be measured to I part in 100 ,000,000 and can be used to accurately measure the Doppler frequency shift of the lines, directly measuring the line-of-sight velocity of the gas to --Im/s precision (winds). The technical and analytical methods developed and used to measure and analyze infrared heterodyne measurements will be described. Examples of studies on Titan, Venus, Mars, Earth, and Jupiter will be presented. 'These include atmospheric dynamics on slowly rotating bodies (Titan [2] and Venus [3] and temperature, composition and chemistry on Mars 141, Venus and Earth. The discovery and studies of unique atmospheric phenomena will also be

Density‐weighted concentric circle trajectories for high resolution brain magnetic resonance spectroscopic imaging at 7T

PubMed Central

Hingerl, Lukas; Moser, Philipp; Považan, Michal; Hangel, Gilbert; Heckova, Eva; Gruber, Stephan; Trattnig, Siegfried; Strasser, Bernhard

2017-01-01

Purpose Full‐slice magnetic resonance spectroscopic imaging at ≥7 T is especially vulnerable to lipid contaminations arising from regions close to the skull. This contamination can be mitigated by improving the point spread function via higher spatial resolution sampling and k‐space filtering, but this prolongs scan times and reduces the signal‐to‐noise ratio (SNR) efficiency. Currently applied parallel imaging methods accelerate magnetic resonance spectroscopic imaging scans at 7T, but increase lipid artifacts and lower SNR‐efficiency further. In this study, we propose an SNR‐efficient spatial‐spectral sampling scheme using concentric circle echo planar trajectories (CONCEPT), which was adapted to intrinsically acquire a Hamming‐weighted k‐space, thus termed density‐weighted‐CONCEPT. This minimizes voxel bleeding, while preserving an optimal SNR. Theory and Methods Trajectories were theoretically derived and verified in phantoms as well as in the human brain via measurements of five volunteers (single‐slice, field‐of‐view 220 × 220 mm2, matrix 64 × 64, scan time 6 min) with free induction decay magnetic resonance spectroscopic imaging. Density‐weighted‐CONCEPT was compared to (a) the originally proposed CONCEPT with equidistant circles (here termed e‐CONCEPT), (b) elliptical phase‐encoding, and (c) 5‐fold Controlled Aliasing In Parallel Imaging Results IN Higher Acceleration accelerated elliptical phase‐encoding. Results By intrinsically sampling a Hamming‐weighted k‐space, density‐weighted‐CONCEPT removed Gibbs‐ringing artifacts and had in vivo +9.5%, +24.4%, and +39.7% higher SNR than e‐CONCEPT, elliptical phase‐encoding, and the Controlled Aliasing In Parallel Imaging Results IN Higher Acceleration accelerated elliptical phase‐encoding (all P < 0.05), respectively, which lead to improved metabolic maps. Conclusion Density‐weighted‐CONCEPT provides clinically attractive full‐slice high‐resolution

Development of a sub-cm high resolution ion Doppler tomography diagnostics for fine structure measurement of guide field reconnection in TS-U

NASA Astrophysics Data System (ADS)

Tanabe, Hiroshi; Koike, Hideya; Hatano, Hironori; Hayashi, Takumi; Cao, Qinghong; Himeno, Shunichi; Kaneda, Taishi; Akimitsu, Moe; Sawada, Asuka; Ono, Yasushi

2017-10-01

A new type of high-throughput/high-resolution 96CH ion Doppler tomography diagnostics has been developed using ``multi-slit'' spectroscopy technique for detailed investigation of fine structure formation during high guide field magnetic reconnection. In the last three years, high field merging experiment in MAST pioneered new frontiers of reconnection heating: formation of highly peaked structure around X-point in high guide field condition (Bt > 0.3 T), outflow dissipation under the influence of better plasma confinement to form high temperature ring structure which aligns with closed flux surface of toroidal plasma, and interaction between ion and electron temperature profile during transport/confinement phase to form triple peak structure (τeiE 4 ms). To investigate more detailed mechanism with in-situ magnetic measurement, the university of Tokyo starts the upgrade of plasma parameters and spatial resolution of optical diagnostics as in MAST. Now, a new type of high-throughput/high-resolution 96CH ion Doppler tomography diagnostics system construction has been completed and it successfully resolved fine structure of ion heating downstream, aligned with closed flux surface formed by reconnected field. This work was supported by JSPS KAKENHI Grant Numbers 15H05750, 15K14279 and 17H04863.

Non-contact high resolution Bessel beam probe for diagnostic imaging of cornea and trabecular meshwork region in eye

NASA Astrophysics Data System (ADS)

Murukeshan, V. M.; Jesmond, Hong Xun J.; Shinoj, V. K.; Baskaran, M.; Tin, Aung

2015-07-01

Primary angle closure glaucoma is a major form of disease that causes blindness in Asia and worldwide. In glaucoma, irregularities in the ocular aqueous outflow system cause an elevation in intraocular pressure (IOP) with subsequent death of retinal ganglion cells, resulting in loss of vision. High resolution visualization of the iridocorneal angle region has great diagnostic value in understanding the disease condition which enables monitoring of surgical interventions that decrease IOP. None of the current diagnostic techniques such as goniophotography, ultrasound biomicroscopy (UBM), anterior segment optical coherence tomography (AS-OCT) and RetCam™ can image with molecular specificity and required spatial resolution that can delineate the trabecular meshwork structures. This paper in this context proposes new concepts and methodology using Bessel beams based illumination and imaging for such diagnostic ocular imaging applications. The salient features using Bessel beams instead of the conventional Gaussian beam, and the optimization challenges in configuring the probe system will be illustrated with porcine eye samples.

Tissue preservation with mass spectroscopic analysis: Implications for cancer diagnostics.

PubMed

Hall, O Morgan; Peer, Cody J; Figg, William D

2018-05-17

Surgical intervention is a common treatment modality for localized cancer. Post-operative analysis involves evaluation of surgical margins to assess whether all malignant tissue has been resected because positive surgical margins lead to a greater likelihood of recurrence. Secondary treatments are utilized to minimize the negative effects of positive surgical margins. Recently, in Science Translational Medicine, Zhang et al describe a new mass spectroscopic technique that could potentially decrease the likelihood of positive surgical margins. Their nondestructive in vivo tissue sampling leads to a highly accurate and rapid cancer diagnosis with great precision between healthy and malignant tissue. This new tool has the potential to improve surgical margins and accelerate cancer diagnostics by analyzing biomolecular signatures of various tissues and diseases.

X-ray spectroscopic diagnostics and modeling of polar-drive implosion experiments on the National Ignition Facility

NASA Astrophysics Data System (ADS)

Hakel, P.; Kyrala, G. A.; Bradley, P. A.; Krasheninnikova, N. S.; Murphy, T. J.; Schmitt, M. J.; Tregillis, I. L.; Kanzleieter, R. J.; Batha, S. H.; Fontes, C. J.; Sherrill, M. E.; Kilcrease, D. P.; Regan, S. P.

2014-06-01

A series of experiments featuring laser-imploded plastic-shell targets filled with hydrogen or deuterium were performed on the National Ignition Facility. The shells (some deuterated) were doped in selected locations with Cu, Ga, and Ge, whose spectroscopic signals (indicative of local plasma conditions) were collected with a time-integrated, 1-D imaging, spectrally resolved, and absolute-intensity calibrated instrument. The experimental spectra compare well with radiation hydrodynamics simulations post-processed with a non-local thermal equilibrium atomic kinetics and spectroscopic-quality radiation-transport model. The obtained degree of agreement between the modeling and experimental data supports the application of spectroscopic techniques for the determination of plasma conditions, which can ultimately lead to the validation of theoretical models for thermonuclear burn in the presence of mix. Furthermore, the use of a lower-Z dopant element (e.g., Fe) is suggested for future experiments, since the ˜2 keV electron temperatures reached in mixed regions are not high enough to drive sufficient H-like Ge and Cu line emissions needed for spectroscopic plasma diagnostics.

Gamma-Ray Imager With High Spatial And Spectral Resolution

NASA Technical Reports Server (NTRS)

Callas, John L.; Varnell, Larry S.; Wheaton, William A.; Mahoney, William A.

1996-01-01

Gamma-ray instrument developed to enable both two-dimensional imaging at relatively high spatial resolution and spectroscopy at fractional-photon-energy resolution of about 10 to the negative 3rd power in photon-energy range from 10 keV to greater than 10 MeV. In its spectroscopic aspect, instrument enables identification of both narrow and weak gamma-ray spectral peaks.

Diagnostic accuracy of cone-beam computed tomography scans with high- and low-resolution modes for the detection of root perforations.

PubMed

Shokri, Abbas; Eskandarloo, Amir; Norouzi, Marouf; Poorolajal, Jalal; Majidi, Gelareh; Aliyaly, Alireza

2018-03-01

This study compared the diagnostic accuracy of cone-beam computed tomography (CBCT) scans obtained with 2 CBCT systems with high- and low-resolution modes for the detection of root perforations in endodontically treated mandibular molars. The root canals of 72 mandibular molars were cleaned and shaped. Perforations measuring 0.2, 0.3, and 0.4 mm in diameter were created at the furcation area of 48 roots, simulating strip perforations, or on the external surfaces of 48 roots, simulating root perforations. Forty-eight roots remained intact (control group). The roots were filled using gutta-percha (Gapadent, Tianjin, China) and AH26 sealer (Dentsply Maillefer, Ballaigues, Switzerland). The CBCT scans were obtained using the NewTom 3G (QR srl, Verona, Italy) and Cranex 3D (Soredex, Helsinki, Finland) CBCT systems in high- and low-resolution modes, and were evaluated by 2 observers. The chi-square test was used to assess the nominal variables. In strip perforations, the accuracies of low- and high-resolution modes were 75% and 83% for NewTom 3G and 67% and 69% for Cranex 3D. In root perforations, the accuracies of low- and high-resolution modes were 79% and 83% for NewTom 3G and was 56% and 73% for Cranex 3D. The accuracy of the 2 CBCT systems was different for the detection of strip and root perforations. The Cranex 3D had non-significantly higher accuracy than the NewTom 3G. In both scanners, the high-resolution mode yielded significantly higher accuracy than the low-resolution mode. The diagnostic accuracy of CBCT scans was not affected by the perforation diameter.

Corrosion investigation of fire-gilded bronze involving high surface resolution spectroscopic imaging

NASA Astrophysics Data System (ADS)

Masi, G.; Chiavari, C.; Avila, J.; Esvan, J.; Raffo, S.; Bignozzi, M. C.; Asensio, M. C.; Robbiola, L.; Martini, C.

2016-03-01

Gilded bronzes are often affected by severe corrosion, due to defects in the Au layer and Au/Cu alloy galvanic coupling, stimulated by large cathodic area of the gilded layer. Galvanic corrosion, triggered by gilding defects, leads to products growth at the Au/bronze interface, inducing blistering or break-up of the Au layer. In this context, fire-gilded bronze replicas prepared by ancient methods (use of spreadable Au-Hg paste) was specifically characterised by compiling complementary spectroscopic and imaging information before/after accelerated ageing with synthetic rain. Fire-gilded bronze samples were chemically imaged in cross-section at nano-metric scale (<200 nm) using high energy and lateral resolution synchrotron radiation photoemission (HR-SRPES) of core levels and valence band after conventional characterisation of the samples by Glow Discharge optical Emission Spectroscopy (GD-OES) and conventional X-ray photoelectron spectroscopy (XPS). We have found a net surface enrichment in Zn and Sn after fire-gilding and presence of metallic Hg, Pb and Cu within the Au layer. Moreover, the composition distribution of the elements together with their oxidation has been determined. It was also revealed that metallic phases including Hg and Pb remain in the gilding after corrosion. Moreover, selective dissolution of Zn and Cu occurs in the crater due to galvanic coupling, which locally induces relative Sn species enrichment (decuprification). The feasibility advantages and disadvantages of chemical imaging using HR-SRPES to study artworks have been investigated on representative replicas.

High resolution spectroscopic study of Be10Lambda;

NASA Astrophysics Data System (ADS)

Gogami, T.; Chen, C.; Kawama, D.; Achenbach, P.; Ahmidouch, A.; Albayrak, I.; Androic, D.; Asaturyan, A.; Asaturyan, R.; Ates, O.; Baturin, P.; Badui, R.; Boeglin, W.; Bono, J.; Brash, E.; Carter, P.; Chiba, A.; Christy, E.; Danagoulian, S.; de Leo, R.; Doi, D.; Elaasar, M.; Ent, R.; Fujii, Y.; Fujita, M.; Furic, M.; Gabrielyan, M.; Gan, L.; Garibaldi, F.; Gaskell, D.; Gasparian, A.; Han, Y.; Hashimoto, O.; Horn, T.; Hu, B.; Hungerford, Ed. V.; Jones, M.; Kanda, H.; Kaneta, M.; Kato, S.; Kawai, M.; Khanal, H.; Kohl, M.; Liyanage, A.; Luo, W.; Maeda, K.; Margaryan, A.; Markowitz, P.; Maruta, T.; Matsumura, A.; Maxwell, V.; Mkrtchyan, A.; Mkrtchyan, H.; Nagao, S.; Nakamura, S. N.; Narayan, A.; Neville, C.; Niculescu, G.; Niculescu, M. I.; Nunez, A.; Nuruzzaman, Okayasu, Y.; Petkovic, T.; Pochodzalla, J.; Qiu, X.; Reinhold, J.; Rodriguez, V. M.; Samanta, C.; Sawatzky, B.; Seva, T.; Shichijo, A.; Tadevosyan, V.; Tang, L.; Taniya, N.; Tsukada, K.; Veilleux, M.; Vulcan, W.; Wesselmann, F. R.; Wood, S. A.; Yamamoto, T.; Ya, L.; Ye, Z.; Yokota, K.; Yuan, L.; Zhamkochyan, S.; Zhu, L.; Hksjlab E05-115 Collaboration

2016-03-01

Spectroscopy of a Be10Lambda; hypernucleus was carried out at JLab Hall C using the (e ,e'K+) reaction. A new magnetic spectrometer system (SPL+HES+HKS), specifically designed for high resolution hypernuclear spectroscopy, was used to obtain an energy spectrum with a resolution of ˜0.78 MeV (FWHM). The well-calibrated spectrometer system of the present experiment using p (e ,e'K+)Λ ,Σ0 reactions allowed us to determine the energy levels; and the binding energy of the ground-state peak (mixture of 1- and 2- states) was found to be BΛ=8.55 ±0.07 (stat . ) ±0.11 (sys . ) MeV. The result indicates that the ground-state energy is shallower than that of an emulsion study by about 0.5 MeV which provides valuable experimental information on the charge symmetry breaking effect in the Λ N interaction.

High resolution spectroscopic study of Be Λ 10

DOE PAGES

Gogami, T.; Chen, C.; Kawama, D.; ...

2016-03-10

Spectroscopy of amore » $$^{10}_{\\Lambda}$$Be hypernucleus was carried out at JLab Hall C using the $$(e,e^{\\prime}K^{+})$$ reaction. A new magnetic spectrometer system (SPL+HES+HKS), specifically designed for high resolution hypernuclear spectroscopy, was used to obtain an energy spectrum with a resolution of 0.78 MeV (FWHM). The well-calibrated spectrometer system of the present experiment using the $$p(e,e^{\\prime}K^{+})\\Lambda,\\Sigma^{0}$$ reactions allowed us to determine the energy levels, and the binding energy of the ground state peak (mixture of 1$$^{-}$$ and 2$$^{-}$$ states) was obtained to be B$$_{\\Lambda}$$=8.55$$\\pm$$0.07(stat.)$$\\pm$$0.11(sys.) MeV. Furthermore, the result indicates that the ground state energy is shallower than that of an emulsion study by about 0.5 MeV which provides valuable experimental information on charge symmetry breaking effect in the $$\\Lambda N$$ interaction.« less

The Gaia FGK benchmark stars. High resolution spectral library

NASA Astrophysics Data System (ADS)

Blanco-Cuaresma, S.; Soubiran, C.; Jofré, P.; Heiter, U.

2014-06-01

Context. An increasing number of high-resolution stellar spectra is available today thanks to many past and ongoing spectroscopic surveys. Consequently, numerous methods have been developed to perform an automatic spectral analysis on a massive amount of data. When reviewing published results, biases arise and they need to be addressed and minimized. Aims: We are providing a homogeneous library with a common set of calibration stars (known as the Gaia FGK benchmark stars) that will allow us to assess stellar analysis methods and calibrate spectroscopic surveys. Methods: High-resolution and signal-to-noise spectra were compiled from different instruments. We developed an automatic process to homogenize the observed data and assess the quality of the resulting library. Results: We built a high-quality library that will facilitate the assessment of spectral analyses and the calibration of present and future spectroscopic surveys. The automation of the process minimizes the human subjectivity and ensures reproducibility. Additionally, it allows us to quickly adapt the library to specific needs that can arise from future spectroscopic analyses. Based on NARVAL and HARPS data obtained within the Gaia Data Processing and Analysis Consortium (DPAC) and coordinated by the GBOG (Ground-Based Observations for Gaia) working group, and on data retrieved from the ESO-ADP database.The library of spectra is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/566/A98

High-resolution tungsten spectroscopy relevant to the diagnostic of high-temperature tokamak plasmas

NASA Astrophysics Data System (ADS)

Rzadkiewicz, J.; Yang, Y.; Kozioł, K.; O'Mullane, M. G.; Patel, A.; Xiao, J.; Yao, K.; Shen, Y.; Lu, D.; Hutton, R.; Zou, Y.; JET Contributors

2018-05-01

The x-ray transitions in Cu- and Ni-like tungsten ions in the 5.19-5.26 Å wavelength range that are relevant as a high-temperature tokamak diagnostic, in particular for JET in the ITER-like wall configuration, have been studied. Tungsten spectra were measured at the upgraded Shanghai- Electron Beam Ion Trap operated with electron-beam energies from 3.16 to 4.55 keV. High-resolution measurements were performed by means of a flat Si 111 crystal spectrometer equipped by a CCD camera. The experimental wavelengths were determined with an accuracy of 0.3-0.4 mÅ. The wavelength of the ground-state transition in Cu-like tungsten from the 3 p53 d104 s 4 d [ (3/2 ,(1/2,5/2 ) 2] 1 /2 level was measured. All measured wavelengths were compared with those measured from JET ITER-like wall plasmas and with other experiments and various theoretical predictions including cowan, relac, multiconfigurational Dirac-Fock (MCDF), and fac calculations. To obtain a higher accuracy from theoretical predictions, the MCDF calculations were extended by taking into account correlation effects (configuration-interaction approach). It was found that such an extension brings the calculations closer to the experimental values in comparison with other calculations.

Hybrid-modality high-resolution imaging: for diagnostic biomedical imaging and sensing for disease diagnosis

NASA Astrophysics Data System (ADS)

Murukeshan, Vadakke M.; Hoong Ta, Lim

2014-11-01

Medical diagnostics in the recent past has seen the challenging trend to come up with dual and multi-modality imaging for implementing better diagnostic procedures. The changes in tissues in the early disease stages are often subtle and can occur beneath the tissue surface. In most of these cases, conventional types of medical imaging using optics may not be able to detect these changes easily due to its penetration depth of the orders of 1 mm. Each imaging modality has its own advantages and limitations, and the use of a single modality is not suitable for every diagnostic applications. Therefore the need for multi or hybrid-modality imaging arises. Combining more than one imaging modalities overcomes the limitation of individual imaging method and integrates the respective advantages into a single setting. In this context, this paper will be focusing on the research and development of two multi-modality imaging platforms. The first platform combines ultrasound and photoacoustic imaging for diagnostic applications in the eye. The second platform consists of optical hyperspectral and photoacoustic imaging for diagnostic applications in the colon. Photoacoustic imaging is used as one of the modalities in both platforms as it can offer deeper penetration depth compared to optical imaging. The optical engineering and research challenges in developing the dual/multi-modality platforms will be discussed, followed by initial results validating the proposed scheme. The proposed schemes offer high spatial and spectral resolution imaging and sensing, and is expected to offer potential biomedical imaging solutions in the near future.

Robust high-resolution quantification of time signals encoded by in vivo magnetic resonance spectroscopy

NASA Astrophysics Data System (ADS)

Belkić, Dževad; Belkić, Karen

2018-01-01

This paper on molecular imaging emphasizes improving specificity of magnetic resonance spectroscopy (MRS) for early cancer diagnostics by high-resolution data analysis. Sensitivity of magnetic resonance imaging (MRI) is excellent, but specificity is insufficient. Specificity is improved with MRS by going beyond morphology to assess the biochemical content of tissue. This is contingent upon accurate data quantification of diagnostically relevant biomolecules. Quantification is spectral analysis which reconstructs chemical shifts, amplitudes and relaxation times of metabolites. Chemical shifts inform on electronic shielding of resonating nuclei bound to different molecular compounds. Oscillation amplitudes in time signals retrieve the abundance of MR sensitive nuclei whose number is proportional to metabolite concentrations. Transverse relaxation times, the reciprocal of decay probabilities of resonances, arise from spin-spin coupling and reflect local field inhomogeneities. In MRS single voxels are used. For volumetric coverage, multi-voxels are employed within a hybrid of MRS and MRI called magnetic resonance spectroscopic imaging (MRSI). Common to MRS and MRSI is encoding of time signals and subsequent spectral analysis. Encoded data do not provide direct clinical information. Spectral analysis of time signals can yield the quantitative information, of which metabolite concentrations are the most clinically important. This information is equivocal with standard data analysis through the non-parametric, low-resolution fast Fourier transform and post-processing via fitting. By applying the fast Padé transform (FPT) with high-resolution, noise suppression and exact quantification via quantum mechanical signal processing, advances are made, presented herein, focusing on four areas of critical public health importance: brain, prostate, breast and ovarian cancers.

Determination of spectroscopic properties of atmospheric molecules from high resolution vacuum ultraviolet cross section and wavelength measurements

NASA Technical Reports Server (NTRS)

Parkinson, W. H.; Yoshino, K.; Freeman, D. E.

1993-01-01

An account is given of progress during the six-month period 1 Nov. 1992 to 30 Apr. 1993 on work on (1) cross section measurements of the Schumann-Runge continuum; (2) the determination of the predissociation linewidths of the Schumann-Runge bands of O2; (3) the determination of the molecular constants of the ground state of O2; (4) cross section measurements of CO2 in wavelength region 120-170 nm; and (4) determination of dissociation energy of O2. The experimental investigations are effected at high resolution with a 6.65 m scanning spectrometer which is, by virtue of its small instrumental width (FWHM = 0.0013 nm), uniquely suitable for cross section measurements of molecular bands with discrete rotational structure. Below 175 nm and in the region of the S-R continuum, synchrotron radiation is suitable for cross section measurements. All of these spectroscopic measurements are needed for accurate calculations of the production of atomic oxygen and penetration of solar radiation into the Earth's atmosphere.

NOSD-1000, the high-temperature nitrous oxide spectroscopic databank

NASA Astrophysics Data System (ADS)

Tashkun, S. A.; Perevalov, V. I.; Lavrentieva, N. N.

2016-07-01

We present a high-temperature version, NOSD-1000, of the nitrous oxide spectroscopic databank. The databank contains the line parameters (positions, intensities, air- and self-broadened half-widths and coefficients of temperature dependence of air- and self-broadened half-widths) of the most abundant isotopologue 14N216O of the nitrous oxide molecule. The reference temperature is Tref=1000 K and the intensity cutoff is Icut=10-25 cm-1/(molecule cm-2). More than 1.4 million lines covering the 260-8310 cm-1 spectral range are included in NOSD-1000. The databank has been generated within the framework of the method of effective operators and based on the global fittings of spectroscopic parameters (parameters of the effective Hamiltonian and effective dipole moment operators) to observed data collected from the literature. Line-by-line simulation of a medium-resolution high-temperature (T=873 K) spectrum has been performed in order to validate the databank. NOSD-1000 is freely accessible via the Internet.

X-ray imaging spectroscopic diagnostics on Nike

NASA Astrophysics Data System (ADS)

Aglitskiy, Y.; Karasik, M.; Serlin, V.; Weaver, J. L.; Oh, J.; Obenschain, S. P.; Ralchenko, Yu.

2017-10-01

Electron temperature and density diagnostics of the laser plasma produced within the focal spot of the NRL's Nike laser are being explored with the help of X-ray imaging spectroscopy. Spectra of He-like and H-like ions were taken by Nike focusing spectrometers in a range of lower (1.8 kev, Si XIV) and higher (6.7 kev, Fe XXV) x-ray energies. Data that were obtained with spatial resolution were translated into the temperature and density as functions of distance from the target. As an example electron density was determined from He-like satellites to Ly-alpha in Si XIV. The dielectronic satellites with intensity ratios that are sensitive to collisional transfer of population between different triplet groups of double-excited states 2l2l' in Si XIII were observed with high spatial and spectral resolution Lineouts taken at different axial distances from the planar Si target show changing spectral shapes due to the different electron densities as determined by supporting non-LTE simulations. These shapes are relatively insensitive to the plasma temperature which was measured using different spectral lines. This work was supported by the US DOE/NNSA.

New LMT High Resolution Imaging and CO Spectroscopic Studies of the Brightest AzTEC 1.1mm Sources

NASA Astrophysics Data System (ADS)

Yun, Min S.; Aretxaga, Itziar; Hughes, David; Montana, A.; Pope, A.; Bruzual, Gustavo; Ferrusca, D.; Rosa Gonzalez, D.; Sanchez-Arguelles, D.; Narayanan, G.; Wilson, Grant; Gim, Hansung; Ibarra, H.; Mo, H.; Lowenthal, James; Zavala, J.; Carrasco, L.; Chavez, M.; Valazquez, M.; Zeballos, M.; Vega, O.; Schloerb, P.; Cybulsky, J. R.; Casey, Caitlin M.; Tang, Y.

2015-08-01

A substantial population of quiescent galaxies with stellar masses exceeding 10 billion solar masses have been found to z~4, suggesting a rapid formation and quenching of massive galaxies at z~6 or earlier. The submillimeter bright galaxies (SMGs) with SFR > 100-1000 solar masses per year represent natural candidates for the progenitor systems undergoing an epoch of rapid formation and cessation of stellar mass build up. Many of the most luminous SMGs are also extremely red and faint in the optical, suggesting a high redshift and are beyond the reach of the current optical spectroscopic redshift surveys. There is also a growing concern that these most luminous SMGs may be blends of several unrelated sources as a result of a poor angular resolution of the existing surveys (18" & 28" for the AzTEC 1.1mm surveys on JCMT and ASTE, respectively). We have obtained new 8" resolution AzTEC images of 40 brightest AzTEC sources previously found in the GOODS and COSMOS fields using the Large Millimeter Telescope (LMT) to examine the multiplicity question and for the identification of multi-wavelength counterparts. We have also conducted a CO redshift survey using the Redshift Search Receiver on the LMT. We will report the results of these analysis and several new CO redshifts.

M-shell resolved high-resolution X-ray spectroscopic study of transient matter evolution driven by hot electrons in kJ-laser produced plasmas

NASA Astrophysics Data System (ADS)

Condamine, F. P.; Šmíd, M.; Renner, O.; Dozières, M.; Thais, F.; Angelo, P.; Rosmej, F. B.

2017-03-01

Hot electrons represent a key subject for high intensity laser produced plasmas and atomic physics. Simulations of the radiative properties indicate a high sensitivity to hot electrons, that in turn provides the possibility for their detailed characterization by high-resolution spectroscopic methods. Of particular interest is X-ray spectroscopy due to reduced photo-absorption in dense matter and their efficient generation by hot electrons (inner-shell ionization/excitation). Here, we report on an experimental campaign conducted at the ns, kJ laser facility PALS at Prague in Czech Republic. Thin copper foils have been irradiated with 1ω pulses. Two spherically bent quartz Bragg crystal spectrometers with high spectral (λ/Δλ > 5000) and spatial resolutions (Δx = 30µm) have been set up simultaneously to achieve a high level of confidence for the complex Kα emission group. In particular, this group, which shows a strong overlap between lines, can be resolved in several substructures. Furthermore, an emission on the red wing of the Kα2 transition (λ = 1.5444A) could be identified with Hartree-Fock atomic structure calculations. We discuss possible implications for the analysis of non-equilibrium phenomena and present first simulations.

High-definition Fourier transform infrared spectroscopic imaging of prostate tissue

NASA Astrophysics Data System (ADS)

Wrobel, Tomasz P.; Kwak, Jin Tae; Kadjacsy-Balla, Andre; Bhargava, Rohit

2016-03-01

Histopathology forms the gold standard for cancer diagnosis and therapy, and generally relies on manual examination of microscopic structural morphology within tissue. Fourier-Transform Infrared (FT-IR) imaging is an emerging vibrational spectroscopic imaging technique, especially in a High-Definition (HD) format, that provides the spatial specificity of microscopy at magnifications used in diagnostic surgical pathology. While it has been shown for standard imaging that IR absorption by tissue creates a strong signal where the spectrum at each pixel is a quantitative "fingerprint" of the molecular composition of the sample, here we show that this fingerprint also enables direct digital pathology without the need for stains or dyes for HD imaging. An assessment of the potential of HD imaging to improve diagnostic pathology accuracy is presented.

Binary Cepheids From High-Angular Resolution

NASA Astrophysics Data System (ADS)

Gallenne, A.; Mérand, A.; Kervella, P.

2015-12-01

Optical interferometry is the only technique giving access to milli-arcsecond (mas) spatial resolution. This is a powerful and unique tool to detect the close orbiting companions of Cepheids, and offers an unique opportunity to make progress in resolving the Cepheid mass discrepancy. Our goal in studying binary Cepheids is to measure the astrometric position of the high-contrast companion, and then combine them with spectroscopic measurements to derive the orbital elements, distances, and dynamical masses. In the course of this program, we developed a new tool, CANDID, to search for high-contrast companions and set detection limits from interferometric observations

Mauna Kea Spectrographic Explorer (MSE): a conceptual design for multi-object high resolution spectrograph

NASA Astrophysics Data System (ADS)

Zhang, Kai; Zhu, Yongtian; Hu, Zhongwen

2016-08-01

The Maunakea Spectroscopic Explorer (MSE) project will transform the CFHT 3.6m optical telescope into a 10m class dedicated multi-object spectroscopic facility, with an ability to simultaneously measure thousands of objects with a spectral resolution range spanning 2,000 to 40,000. MSE will develop two spectrographic facilities to meet the science requirements. These are respectively, the Low/Medium Resolution spectrographs (LMRS) and High Resolution spectrographs (HRS). Multi-object high resolution spectrographs with total of 1,156 fibers is a big challenge, one that has never been attempted for a 10m class telescope. To date, most spectral survey facilities work in single order low/medium resolution mode, and only a few Wide Field Spectrographs (WFS) provide a cross-dispersion high resolution mode with a limited number of orders. Nanjing Institute of Astronomical Optics and Technology (NIAOT) propose a conceptual design with the use of novel image slicer arrays and single order immersed Volume Phase Holographic (VPH) grating for the MSE multi-object high resolution spectrographs. The conceptual scheme contains six identical fiber-link spectrographs, each of which simultaneously covers three restricted bands (λ/30, λ/30, λ/15) in the optical regime, with spectral resolution of 40,000 in Blue/Visible bands (400nm / 490nm) and 20,000 in Red band (650nm). The details of the design is presented in this paper.

High resolution FTIR spectroscopic study of the ν4 band of CH 3CHF 2 enclosed in a flow of cold N 2 gas

NASA Astrophysics Data System (ADS)

Appadoo, Dominique R. T.; Robertson, Evan G.; McNaughton, Don

2003-01-01

An enclosive flow cooling (EFC) cell has been constructed, and coupled to a Brüker IFS 120HR high resolution Fourier transform spectrometer to record rotationally cold absorption spectra of gases of atmospheric interest at high spectral resolution. The new system has been characterized using N 2O, revealing that rotational temperatures as cold as 110 K are readily attainable using liquid nitrogen as a cryogen. Infrared spectra of the ν4 band of 1,1-difluoroethane (R152a), CH 3CHF 2, cooled in the EFC cell have been measured at a resolution of 0.0019 cm-1. Eight hundred and twenty rovibrational transitions of the weak ν4 band with 2⩽ J'⩽46 and Kc'⩽16 were assigned and fitted to Watson's A-reduced Hamiltonian. The ν4 CH 3 symmetric deformation ( a/c-type) was found to be coupled to the ν13 asymmetric deformation ( b-type) via an a-axis Coriolis interaction. In the ensuing analysis, values of spectroscopic constants were obtained for both the ν4 and dark ν13 states. Supporting ab initio calculations up to the MP2/TZV+(3 df,3 p) level are presented.

Fast Spectroscopic Imaging and Field Compensation Using Frequency Modulation at Ultra-High-Field

NASA Astrophysics Data System (ADS)

Jang, Albert Woo Ju

The high energy phosphates (HEP) in the myocardium, which are critical to understanding the cardiac function in both normal and pathophysiologic states, can be assessed non-invasively in vivo using phosphorus-31 (31P) spectroscopy. Compared to proton, for the same volume and magnetic field strength, the available signal-to-noise (SNR) ratio of the HEP metabolites is orders of magnitude lower mainly due to its intrinsically low concentration. Hence, cardiac spectroscopy greatly benefits when performed at ultra-high-fields (UHF, ≥ 7 T), both in terms of increased SNR and increased spectroscopic resolution. However, at ultra-high-field strengths, complications arise from the RF transmit wavelength becoming comparable or smaller than the field-of-view (FOV), thus exhibiting wave-like behavior. Furthermore, even with the spectroscopic resolution afforded at UHF, measuring myocardial inorganic phosphate (Pi) is still a challenge and has been a major barrier in extracting the ATP turnover rate. Recently, an indirect way of extracting the ATP hydrolysis rate forgoing direct measurement of Pi was established. In this work, we combine this method with the T1 nom method to monitor the transmural distribution of forward creatine kinase reaction (kf,CK) and ATP hydrolysis rate (kr,ATPase) of the myocardium, effectively reducing data acquisition time by up to an order of magnitude. In addition, a new class of 2D FM pulses and multidimensional adiabatic pulses are presented, which can compensate for B1 inhomogeneity through its spatiotemporal properties. These pulses should be valuable for spectroscopic applications at ultra-high-fields.

L-shell spectroscopic diagnostics of radiation from krypton HED plasma sources.

PubMed

Petkov, E E; Safronova, A S; Kantsyrev, V L; Shlyaptseva, V V; Rawat, R S; Tan, K S; Beiersdorfer, P; Hell, N; Brown, G V

2016-11-01

X-ray spectroscopy is a useful tool for diagnosing plasma sources due to its non-invasive nature. One such source is the dense plasma focus (DPF). Recent interest has developed to demonstrate its potential application as a soft x-ray source. We present the first spectroscopic studies of krypton high energy density plasmas produced on a 3 kJ DPF device in Singapore. In order to diagnose spectral features, and to obtain a more comprehensive understanding of plasma parameters, a new non-local thermodynamic equilibrium L-shell kinetic model for krypton was developed. It has the capability of incorporating hot electrons, with different electron distribution functions, in order to examine the effects that they have on emission spectra. To further substantiate the validity of this model, it is also benchmarked with data gathered from experiments on the electron beam ion trap (EBIT) at Lawrence Livermore National Laboratory, where data were collected using the high resolution EBIT calorimeter spectrometer.

L-shell spectroscopic diagnostics of radiation from krypton HED plasma sources

DOE PAGES

Petkov, E. E.; Safronova, A. S.; Kantsyrev, V. L.; ...

2016-08-09

We report that X-ray spectroscopy is a useful tool for diagnosing plasma sources due to its non-invasive nature. One such source is the dense plasma focus (DPF). Recent interest has developed to demonstrate its potential application as a soft x-ray source. We present the first spectroscopic studies of krypton high energy density plasmas produced on a 3 kJ DPF device in Singapore. In order to diagnose spectral features, and to obtain a more comprehensive understanding of plasma parameters, a new non-local thermodynamic equilibrium L-shell kinetic model for krypton was developed. It has the capability of incorporating hot electrons, with differentmore » electron distribution functions, in order to examine the effects that they have on emission spectra. Finally, to further substantiate the validity of this model, it is also benchmarked with data gathered from experiments on the electron beam ion trap (EBIT) at Lawrence Livermore National Laboratory, where data were collected using the high resolution EBIT calorimeter spectrometer.« less

L-shell spectroscopic diagnostics of radiation from krypton HED plasma sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Petkov, E. E., E-mail: emilp@unr.edu; Safronova, A. S.; Kantsyrev, V. L.

2016-11-15

X-ray spectroscopy is a useful tool for diagnosing plasma sources due to its non-invasive nature. One such source is the dense plasma focus (DPF). Recent interest has developed to demonstrate its potential application as a soft x-ray source. We present the first spectroscopic studies of krypton high energy density plasmas produced on a 3 kJ DPF device in Singapore. In order to diagnose spectral features, and to obtain a more comprehensive understanding of plasma parameters, a new non-local thermodynamic equilibrium L-shell kinetic model for krypton was developed. It has the capability of incorporating hot electrons, with different electron distribution functions,more » in order to examine the effects that they have on emission spectra. To further substantiate the validity of this model, it is also benchmarked with data gathered from experiments on the electron beam ion trap (EBIT) at Lawrence Livermore National Laboratory, where data were collected using the high resolution EBIT calorimeter spectrometer.« less

High-resolution MRI in detecting subareolar breast abscess.

PubMed

Fu, Peifen; Kurihara, Yasuyuki; Kanemaki, Yoshihide; Okamoto, Kyoko; Nakajima, Yasuo; Fukuda, Mamoru; Maeda, Ichiro

2007-06-01

Because subareolar breast abscess has a high recurrence rate, a more effective imaging technique is needed to comprehensively visualize the lesions and guide surgery. We performed a high-resolution MRI technique using a microscopy coil to reveal the characteristics and extent of subareolar breast abscess. High-resolution MRI has potential diagnostic value in subareolar breast abscess. This technique can be used to guide surgery with the aim of reducing the recurrence rate.

Coronal Heating and the Need for High-Resolution Observations

NASA Technical Reports Server (NTRS)

Klimchuk, James A.

2008-01-01

Despite excellent progress in recent years in understanding coronal heating, there remain many crucial questions that are still unanswered. Limitations in the observations are one important reason. Both theoretical and observational considerations point to the importance of small spatial scales, impulsive energy release, strong dynamics, and extreme plasma nonuniformity. As a consequence, high spatial resolution, broad temperature coverage, high temperature fidelity, and sensitivity to velocities and densities are all critical observational parameters. Current instruments lack one or more of these properties, and this has led to considerable ambiguity and confusion. In this talk, I will discuss recent ideas about coronal heating and emphasize that high spatial resolution observations, especially spectroscopic observations, are needed to make major progress on this important problem.

Metabolite-cycled density-weighted concentric rings k-space trajectory (DW-CRT) enables high-resolution 1 H magnetic resonance spectroscopic imaging at 3-Tesla.

PubMed

Steel, Adam; Chiew, Mark; Jezzard, Peter; Voets, Natalie L; Plaha, Puneet; Thomas, Michael Albert; Stagg, Charlotte J; Emir, Uzay E

2018-05-17

Magnetic resonance spectroscopic imaging (MRSI) is a promising technique in both experimental and clinical settings. However, to date, MRSI has been hampered by prohibitively long acquisition times and artifacts caused by subject motion and hardware-related frequency drift. In the present study, we demonstrate that density weighted concentric ring trajectory (DW-CRT) k-space sampling in combination with semi-LASER excitation and metabolite-cycling enables high-resolution MRSI data to be rapidly acquired at 3 Tesla. Single-slice full-intensity MRSI data (short echo time (TE) semi-LASER TE = 32 ms) were acquired from 6 healthy volunteers with an in-plane resolution of 5 × 5 mm in 13 min 30 sec using this approach. Using LCModel analysis, we found that the acquired spectra allowed for the mapping of total N-acetylaspartate (median Cramer-Rao Lower Bound [CRLB] = 3%), glutamate+glutamine (8%), and glutathione (13%). In addition, we demonstrate potential clinical utility of this technique by optimizing the TE to detect 2-hydroxyglutarate (long TE semi-LASER, TE = 110 ms), to produce relevant high-resolution metabolite maps of grade III IDH-mutant oligodendroglioma in a single patient. This study demonstrates the potential utility of MRSI in the clinical setting at 3 Tesla.

Exploitation of high resolution beam spectroscopy diagnostics on MAST

NASA Astrophysics Data System (ADS)

Michael, Clive; Debock, Maarten; Conway, Neil; Akers, Rob; Appel, Lynton; Field, Anthony; Walsh, Mike; Wisse, Marco

2009-11-01

Recent developments in beam spectroscopy on MAST, including CXRS, MSE and a pilot FIDA system have revealed new information about phenomena such as ITBs, MHD instabilities, transport and fast particle physics. For example, ITBs in the ion temperature and toroidal rotation have been observed with the 64ch CXRS system, while reverse-shear q profiles have been observed with the recently commissioned 35ch MSE system. Thus, the synergy of these diagnostics helps us to understand, among other things, the role of magnetic and rotational shear on ITBs. MSE measurements have also helped to understand MHD phenomena such as locked modes (characterized by changes in toroidal momentum, revealed by CXRS), sawteeth, and internal reconnection events. Finally, the temporal/spatial resolution and SNR of the MSE system have been exploited. Interesting results include the detection of low frequency (˜2kHz) magnetic field fluctuations, characterization of the radial structure of higher frequency (<100kHz) broadband and coherent density (BES) fluctuations, and the identification of short scale length features (˜1.8cm) in the current profile near the edge pedestal.

High and ultra-high resolution metabolite mapping of the human brain using 1H FID MRSI at 9.4T.

PubMed

Nassirpour, Sahar; Chang, Paul; Henning, Anke

2018-03-01

Magnetic resonance spectroscopic imaging (MRSI) is a promising technique for mapping the spatial distribution of multiple metabolites in the human brain. These metabolite maps can be used as a diagnostic tool to gain insight into several biochemical processes and diseases in the brain. In comparison to lower field strengths, MRSI at ultra-high field strengths benefits from a higher signal to noise ratio (SNR) as well as higher chemical shift dispersion, and hence spectral resolution. This study combines the benefits of an ultra-high field magnet with the advantages of an ultra-short TE and TR single-slice FID-MRSI sequence (such as negligible J-evolution and loss of SNR due to T 2 relaxation effects) and presents the first metabolite maps acquired at 9.4T in the healthy human brain at both high (voxel size of 97.6µL) and ultra-high (voxel size of 24.4µL) spatial resolutions in a scan time of 11 and 46min respectively. In comparison to lower field strengths, more anatomically-detailed maps with higher SNR from a larger number of metabolites are shown. A total of 12 metabolites including glutamate (Glu), glutamine (Gln), N-acetyl-aspartyl-glutamate (NAAG), Gamma-aminobutyric acid (GABA) and glutathione (GSH) are reliably mapped. Comprehensive description of the methodology behind these maps is provided. Copyright © 2016 Elsevier Inc. All rights reserved.

Improved image quality and diagnostic potential using ultra-high-resolution computed tomography of the lung with small scan FOV: A prospective study

PubMed Central

Wang, Yali; Hamal, Preeti; You, Xiaofang; Mao, Haixia; Li, Fei; Sun, Xiwen

2017-01-01

The aim of this study was to assess whether CT imaging using an ultra-high-resolution CT (UHRCT) scan with a small scan field of view (FOV) provides higher image quality and helps to reduce the follow-up period compared with a conventional high-resolution CT (CHRCT) scan. We identified patients with at least one pulmonary nodule at our hospital from July 2015 to November 2015. CHRCT and UHRCT scans were conducted in all enrolled patients. Three experienced radiologists evaluated the image quality using a 5-point score and made diagnoses. The paired images were displayed side by side in a random manner and annotations of scan information were removed. The following parameters including image quality, diagnostic confidence of radiologists, follow-up recommendations and diagnostic accuracy were assessed. A total of 52 patients (62 nodules) were included in this study. UHRCT scan provides a better image quality regarding the margin of nodules and solid internal component compared to that of CHRCT (P < 0.05). Readers have higher diagnostic confidence based on the UHRCT images than of CHRCT images (P<0.05). The follow-up recommendations were significantly different between UHRCT and CHRCT images (P<0.05). Compared with the surgical pathological findings, UHRCT had a relative higher diagnostic accuracy than CHRCT (P > 0.05). These findings suggest that the UHRCT prototype scanner provides a better image quality of subsolid nodules compared to CHRCT and contributes significantly to reduce the patients' follow-up period. PMID:28231320

Development and Testing of an LED-Based Near-Infrared Sensor for Human Kidney Tumor Diagnostics

PubMed Central

Zabarylo, Urszula; Kirsanov, Dmitry; Belikova, Valeria; Ageev, Vladimir; Usenov, Iskander; Galyanin, Vladislav; Minet, Olaf; Sakharova, Tatiana; Danielyan, Georgy; Feliksberger, Elena; Artyushenko, Viacheslav

2017-01-01

Optical spectroscopy is increasingly used for cancer diagnostics. Tumor detection feasibility in human kidney samples using mid- and near-infrared (NIR) spectroscopy, fluorescence spectroscopy, and Raman spectroscopy has been reported (Artyushenko et al., Spectral fiber sensors for cancer diagnostics in vitro. In Proceedings of the European Conference on Biomedical Optics, Munich, Germany, 21–25 June 2015). In the present work, a simplification of the NIR spectroscopic analysis for cancer diagnostics was studied. The conventional high-resolution NIR spectroscopic method of kidney tumor diagnostics was replaced by a compact optical sensing device constructively represented by a set of four light-emitting diodes (LEDs) at selected wavelengths and one detecting photodiode. Two sensor prototypes were tested using 14 in vitro clinical samples of 7 different patients. Statistical data evaluation using principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA) confirmed the general applicability of the LED-based sensing approach to kidney tumor detection. An additional validation of the results was performed by means of sample permutation. PMID:28825612

The Relationship of Comorbidities and Patient Navigation to Time to Diagnostic Resolution after Abnormal Cancer Screening

PubMed Central

Whitley, Elizabeth M; Raich, Peter C; Dudley, Donald J; Freund, Karen M; Paskett, Electra D; Patierno, Steven R; Simon, Melissa; Warren-Mears, Victoria; Snyder, Frederick R

2016-01-01

Background Whether patient navigation improves outcomes in patients with comorbidities is unknown. Study aims were to determine the effect of comorbidities on time to diagnostic resolution following an abnormal cancer screening test, and to examine for patients with comorbidities, if patient navigation improves timeliness and likelihood of diagnostic resolution compared to patients without navigation. Methods A secondary analysis from the Patient Navigation Research Program sites that collected comorbidity data using the Charlson Comorbidity Index (CCI) was conducted. Participants were 6,349 patients with abnormal breast, cervical, colon or prostate cancer screening tests between 2007 and 2011. The intervention was patient navigation or usual care. CCI data were highly skewed across projects and cancer sites and were categorized as 0, no comorbidities identified, CCI score of 0 (76% of cases); 1, CCI score of 1 (16% of cases); or 2, CCI score of ≥2 (8% of cases). A separate adjusted hazards ratio for each site and cancer type was obtained, and then pooled using meta-analysis random effects methodology. Results Having a CCI score of ≥2 delayed the time to diagnostic resolution following an abnormal cancer screening test compared with those with fewer than one comorbidity. Patient Navigation reduced delays in diagnostic resolution with the greatest benefit seen in those with a CCI score of ≥2. Conclusions Persons with a CCI score of ≥2 experienced significant delays in timely diagnostic care compared to patients without comorbidities. Patient navigation was effective in reducing delays in diagnostic resolution among those with CCI scores > 1. PMID:27648520

VizieR Online Data Catalog: Spectroscopic analysis of 348 red giants (Zielinski+, 2012)

NASA Astrophysics Data System (ADS)

Zielinski, P.; Niedzielski, A.; Wolszczan, A.; Adamow, M.; Nowak, G.

2012-10-01

The atmospheric parameters were derived using a strictly spectroscopic method based on the LTE analysis of equivalent widths of FeI and FeII lines. With existing photometric data and the Hipparcos parallaxes, we estimated stellar masses and ages via evolutionary tracks fitting. The stellar radii were calculated from either estimated masses and the spectroscopic logg or from the spectroscopic Teff and estimated luminosities. The absolute radial velocities were obtained by cross-correlating spectra with a numerical template. Our high-quality, high-resolution optical spectra have been collected since 2004 with the Hobby-Eberly Telescope (HET), located in the McDonald Observatory. The telescope was equipped with the High Resolution Spectrograph (HRS; R~60000 resolution). (2 data files).

High-resolution line-shape spectroscopy during a laser pulse based on Dual-Broad-Band-CARS interferometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vereschagin, Konstantin A; Vereschagin, Alexey K; Smirnov, Valery V

2006-07-31

A high-resolution spectroscopic method is developed for recording Raman spectra of molecular transitions in transient objects during a laser pulse with a resolution of {approx}0.1 cm{sup -1}. The method is based on CARS spectroscopy using a Fabry-Perot interferometer for spectral analysis of the CARS signal and detecting a circular interferometric pattern on a two-dimensional multichannel photodetector. It is shown that the use of the Dual-Broad-Band-CARS configuration to obtain the CARS process provides the efficient averaging of the spectral-amplitude noise of the CARS signal generated by a laser pulse and, in combination with the angular integration of the two-dimensional interference pattern,more » considerably improves the quality of interferograms. The method was tested upon diagnostics of the transient oxygen-hydrogen flame where information on the shapes of spectral lines of the Q-branch of hydrogen molecules required for measuring temperature was simultaneously obtained and used. (special issue devoted to the 90th anniversary of a.m. prokhorov)« less

Optical and laser spectroscopic diagnostics for energy applications

NASA Astrophysics Data System (ADS)

Tripathi, Markandey Mani

The continuing need for greater energy security and energy independence has motivated researchers to develop new energy technologies for better energy resource management and efficient energy usage. The focus of this dissertation is the development of optical (spectroscopic) sensing methodologies for various fuels, and energy applications. A fiber-optic NIR sensing methodology was developed for predicting water content in bio-oil. The feasibility of using the designed near infrared (NIR) system for estimating water content in bio-oil was tested by applying multivariate analysis to NIR spectral data. The calibration results demonstrated that the spectral information can successfully predict the bio-oil water content (from 16% to 36%). The effect of ultraviolet (UV) light on the chemical stability of bio-oil was studied by employing laser-induced fluorescence (LIF) spectroscopy. To simulate the UV light exposure, a laser in the UV region (325 nm) was employed for bio-oil excitation. The LIF, as a signature of chemical change, was recorded from bio-oil. From this study, it was concluded that phenols present in the bio-oil show chemical instability, when exposed to UV light. A laser-induced breakdown spectroscopy (LIBS)-based optical sensor was designed, developed, and tested for detection of four important trace impurities in rocket fuel (hydrogen). The sensor can simultaneously measure the concentrations of nitrogen, argon, oxygen, and helium in hydrogen from storage tanks and supply lines. The sensor had estimated lower detection limits of 80 ppm for nitrogen, 97 ppm for argon, 10 ppm for oxygen, and 25 ppm for helium. A chemiluminescence-based spectroscopic diagnostics were performed to measure equivalence ratios in methane-air premixed flames. A partial least-squares regression (PLS-R)-based multivariate sensing methodology was investigated. It was found that the equivalence ratios predicted with the PLS-R-based multivariate calibration model matched with the

A tangentially viewing fast ion D-alpha diagnostic for NSTX.

PubMed

Bortolon, A; Heidbrink, W W; Podestà, M

2010-10-01

A second fast ion D-alpha (FIDA) installation is planned at NSTX to complement the present perpendicular viewing FIDA diagnostics. Following the present diagnostic scheme, the new diagnostic will consist of two instruments: a spectroscopic diagnostic that measures fast ion spectra and profiles at 16 radial points with 5-10 ms resolution and a system that uses a band pass filter and photomultiplier to measure changes in FIDA light with 50 kHz sampling rate. The new pair of FIDA instruments will view the heating beams tangentially. The viewing geometry minimizes spectral contamination by beam emission or edge sources of background emission. The improved velocity-space resolution will provide detailed information about neutral-beam current drive and about fast ion acceleration and transport by injected radio frequency waves and plasma instabilities.

Relation of comorbidities and patient navigation with the time to diagnostic resolution after abnormal cancer screening.

PubMed

Whitley, Elizabeth M; Raich, Peter C; Dudley, Donald J; Freund, Karen M; Paskett, Electra D; Patierno, Steven R; Simon, Melissa; Warren-Mears, Victoria; Snyder, Frederick R

2017-01-01

Whether patient navigation improves outcomes for patients with comorbidities is unknown. The aims of this study were to determine the effect of comorbidities on the time to diagnostic resolution after an abnormal cancer screening test and to examine whether patient navigation improves the timeliness and likelihood of diagnostic resolution for patients with comorbidities in comparison with no navigation. A secondary analysis of comorbidity data collected by Patient Navigation Research Program sites using the Charlson Comorbidity Index (CCI) was conducted. The participants were 6,349 patients with abnormal breast, cervical, colon, or prostate cancer screening tests between 2007 and 2011. The intervention was patient navigation or usual care. The CCI data were highly skewed across projects and cancer sites, and the CCI scores were categorized as 0 (CCI score of 0 or no comorbidities identified; 76% of cases); 1 (CCI score of 1; 16% of cases), or 2 (CCI score ≥ 2; 8% of cases). Separate adjusted hazard ratios for each site and cancer type were obtained, and then they were pooled with a meta-analysis random effects methodology. Patients with a CCI score ≥ 2 had delayed diagnostic resolution after an abnormal cancer screening test in comparison with those with no comorbidities. Patient navigation reduced delays in diagnostic resolution, with the greatest benefits seen for those with a CCI score ≥ 2. Persons with a CCI score ≥ 2 experienced significant delays in timely diagnostic care in comparison with patients without comorbidities. Patient navigation was effective in reducing delays in diagnostic resolution among those with CCI scores > 1. Cancer 2017;123:312-318. © 2016 American Cancer Society. © 2016 American Cancer Society.

Spectroscopic Characterisation of CARMENES Target Candidates from FEROS, CAFE and HRS High-Resolution Spectra

NASA Astrophysics Data System (ADS)

Passegger, Vera Maria; Reiners, Ansgar; Jeffers, Sandra V.; Wende, Sebastian; Schöfer, Patrick; Amado, Pedro J.; Caballero, Jose A.; Montes, David; Mundt, Reinhard; Ribas, Ignasi; Quirrenbach, Andreas

2016-07-01

CARMENES (Calar Alto high-Resolution search for M dwarfs with Exoearths with Near-infrared and optical Échelle Spectrographs) started a new planet survey on M-dwarfs in January this year. The new high-resolution spectrographs are operating in the visible and near-infrared at Calar Alto Observatory. They will perform high-accuracy radial-velocity measurements (goal 1 m s-1) of about 300 M-dwarfs with the aim to detect low-mass planets within habitable zones. We characterised the candidate sample for CARMENES and provide fundamental parameters for these stars in order to constrain planetary properties and understand star-planet systems. Using state-of-the-art model atmospheres (PHOENIX-ACES) and χ2-minimization with a downhill-simplex method we determine effective temperature, surface gravity and metallicity [Fe/H] for high-resolution spectra of around 480 stars of spectral types M0.0-6.5V taken with FEROS, CAFE and HRS. We find good agreement between the models and our observed high-resolution spectra. We show the performance of the algorithm, as well as results, parameter and spectral type distributions for the CARMENES candidate sample, which is used to define the CARMENES target sample. We also present first preliminary results obtained from CARMENES spectra.

Comment on the paper ;NDSD-1000: High-resolution, high-temperature nitrogen dioxide spectroscopic Databank; by A.A. Lukashevskaya, N.N. Lavrentieva, A.C. Dudaryonok, V.I. Perevalov, J Quant Spectrosc Radiat Transfer 2016;184:205-17

NASA Astrophysics Data System (ADS)

Perrin, A.; Ndao, M.; Manceron, L.

2017-10-01

A recent paper [1] presents a high-resolution, high-temperature version of the Nitrogen Dioxide Spectroscopic Databank called NDSD-1000. The NDSD-1000 database contains line parameters (positions, intensities, self- and air-broadening coefficients, exponents of the temperature dependence of self- and air-broadening coefficients) for numerous cold and hot bands of the 14N16O2 isotopomer of nitrogen dioxide. The parameters used for the line positions and intensities calculation were generated through a global modeling of experimental data collected in the literature within the framework of the method of effective operators. However, the form of the effective dipole moment operator used to compute the NO2 line intensities in the NDSD-1000 database differs from the classical one used for line intensities calculation in the NO2 infrared literature [12]. Using Fourier transform spectra recorded at high resolution in the 6.3 μm region, it is shown here, that the NDSD-1000 formulation is incorrect since the computed intensities do not account properly for the (Int(+)/Int(-)) intensity ratio between the (+) (J = N+ 1/2) and (-) (J = N-1/2) electron - spin rotation subcomponents of the computed vibration rotation transitions. On the other hand, in the HITRAN or GEISA spectroscopic databases, the NO2 line intensities were computed using the classical theoretical approach, and it is shown here that these data lead to a significant better agreement between the observed and calculated spectra.

VizieR Online Data Catalog: RAVE J203843.2-002333 high-resolution spectroscopy (Placco+, 2017)

NASA Astrophysics Data System (ADS)

Placco, V. M.; Holmbeck, E. M.; Frebel, A.; Beers, T. C.; Surman, R. A.; Ji, A. P.; Ezzeddine, R.; Points, S. D.; Kaleida, C. C.; Hansen, T. T.; Sakari, C. M.; Casey, A. R.

2018-03-01

Medium-resolution spectroscopic follow-up was carried out with the Mayall 4m Telescope at Kitt Peak National Observatory. The observations were obtained in semester 2014B, using the R-C spectrograph covering the wavelength range [3500,6000]Å (R~1600). High-resolution spectroscopic data were obtained during the 2014B and 2016A semesters, using the Magellan Inamori Kyocera Echelle (MIKE) spectrograph on the Magellan/Clay Telescope at Las Campanas Observatory. For the 2014B run, the setup yielding a resolving power of R~38000 (blue spectral range) and R~30000 (red spectral range). For the 2016A run, the resolving power was R~66000 (coverage [~3500,9000]Å). (4 data files).

High-Resolution Light Transmission Spectroscopy of Nanoparticles in Real Time

NASA Astrophysics Data System (ADS)

Tanner, Carol; Sun, Nan; Deatsch, Alison; Li, Frank; Ruggiero, Steven

2017-04-01

As implemented here, Light Transmission Spectroscopy (LTS) is a high-resolution real-time technique for eliminating spectral noise and systematic effects in wide band spectroscopic measurements of nanoparticles. In this work, we combine LTS with spectral inversion for the purpose of characterizing the size, shape, and number of nanoparticles in solution. The apparatus employs a wide-band multi-wavelength light source and grating spectrometers coupled to CCD detectors. The light source ranges from 210 to 2000 nm, and the wavelength dependent light detection system ranges from 200 to 1100 nm with <=1 nm resolution. With this system, nanoparticles ranging from 1 to 3000 nm diameters can be studied. The nanoparticles are typically suspended in pure water or water-based buffer solutions. For testing and calibration purposes, results are presented for nanoparticles composed of polystyrene and gold. Mie theory is used to model the total extinction cross-section, and spectral inversion is employed to obtain quantitative particle size distributions. Discussed are the precision, accuracy, resolution, and sensitivity of our results. The technique is quite versatile and can be applied to spectroscopic investigations where wideband, accurate, low-noise, real-time spectra are desired. University of Notre Dame Office of Research, College of Science, Department of Physics, and USDA.

Spectroscopic imaging of limiter heat and particle fluxes and the resulting impurity sources during Wendelstein 7-X startup plasmas.

PubMed

Stephey, L; Wurden, G A; Schmitz, O; Frerichs, H; Effenberg, F; Biedermann, C; Harris, J; König, R; Kornejew, P; Krychowiak, M; Unterberg, E A

2016-11-01

A combined IR and visible camera system [G. A. Wurden et al., "A high resolution IR/visible imaging system for the W7-X limiter," Rev. Sci. Instrum. (these proceedings)] and a filterscope system [R. J. Colchin et al., Rev. Sci. Instrum. 74, 2068 (2003)] were implemented together to obtain spectroscopic data of limiter and first wall recycling and impurity sources during Wendelstein 7-X startup plasmas. Both systems together provided excellent temporal and spatial spectroscopic resolution of limiter 3. Narrowband interference filters in front of the camera yielded C-III and H α photon flux, and the filterscope system provided H α , H β , He-I, He-II, C-II, and visible bremsstrahlung data. The filterscopes made additional measurements of several points on the W7-X vacuum vessel to yield wall recycling fluxes. The resulting photon flux from both the visible camera and filterscopes can then be compared to an EMC3-EIRENE synthetic diagnostic [H. Frerichs et al., "Synthetic plasma edge diagnostics for EMC3-EIRENE, highlighted for Wendelstein 7-X," Rev. Sci. Instrum. (these proceedings)] to infer both a limiter particle flux and wall particle flux, both of which will ultimately be used to infer the complete particle balance and particle confinement time τ P .

Comparison of High-Resolution MR Imaging and Digital Subtraction Angiography for the Characterization and Diagnosis of Intracranial Artery Disease.

PubMed

Lee, N J; Chung, M S; Jung, S C; Kim, H S; Choi, C-G; Kim, S J; Lee, D H; Suh, D C; Kwon, S U; Kang, D-W; Kim, J S

2016-12-01

High-resolution MR imaging has recently been introduced as a promising diagnostic modality in intracranial artery disease. Our aim was to compare high-resolution MR imaging with digital subtraction angiography for the characterization and diagnosis of various intracranial artery diseases. Thirty-seven patients who had undergone both high-resolution MR imaging and DSA for intracranial artery disease were enrolled in our study (August 2011 to April 2014). The time interval between the high-resolution MR imaging and DSA was within 1 month. The degree of stenosis and the minimal luminal diameter were independently measured by 2 observers in both DSA and high-resolution MR imaging, and the results were compared. Two observers independently diagnosed intracranial artery diseases on DSA and high-resolution MR imaging. The time interval between the diagnoses on DSA and high-resolution MR imaging was 2 weeks. Interobserver diagnostic agreement for each technique and intermodality diagnostic agreement for each observer were acquired. High-resolution MR imaging showed moderate-to-excellent agreement (interclass correlation coefficient = 0.892-0.949; κ = 0.548-0.614) and significant correlations (R = 0.766-892) with DSA on the degree of stenosis and minimal luminal diameter. The interobserver diagnostic agreement was good for DSA (κ = 0.643) and excellent for high-resolution MR imaging (κ = 0.818). The intermodality diagnostic agreement was good (κ = 0.704) for observer 1 and moderate (κ = 0.579) for observer 2, respectively. High-resolution MR imaging may be an imaging method comparable with DSA for the characterization and diagnosis of various intracranial artery diseases. © 2016 by American Journal of Neuroradiology.

Improved Temperature Diagnostic for Non-Neutral Plasmas with Single-Electron Resolution

NASA Astrophysics Data System (ADS)

Shanman, Sabrina; Evans, Lenny; Fajans, Joel; Hunter, Eric; Nelson, Cheyenne; Sierra, Carlos; Wurtele, Jonathan

2016-10-01

Plasma temperature diagnostics in a Penning-Malmberg trap are essential for reliably obtaining cold, non-neutral plasmas. We have developed a setup for detecting the initial electrons that escape from a trapped pure electron plasma as the confining electrode potential is slowly reduced. The setup minimizes external noise by using a silicon photomultiplier to capture light emitted from an MCP-amplified phosphor screen. To take advantage of this enhanced resolution, we have developed a new plasma temperature diagnostic analysis procedure which takes discrete electron arrival times as input. We have run extensive simulations comparing this new discrete algorithm to our existing exponential fitting algorithm. These simulations are used to explore the behavior of these two temperature diagnostic procedures at low N and at high electronic noise. This work was supported by the DOE DE-FG02-06ER54904, and the NSF 1500538-PHY.

Accurate Emission Line Diagnostics at High Redshift

NASA Astrophysics Data System (ADS)

Jones, Tucker

2017-08-01

How do the physical conditions of high redshift galaxies differ from those seen locally? Spectroscopic surveys have invested hundreds of nights of 8- and 10-meter telescope time as well as hundreds of Hubble orbits to study evolution in the galaxy population at redshifts z 0.5-4 using rest-frame optical strong emission line diagnostics. These surveys reveal evolution in the gas excitation with redshift but the physical cause is not yet understood. Consequently there are large systematic errors in derived quantities such as metallicity.We have used direct measurements of gas density, temperature, and metallicity in a unique sample at z=0.8 to determine reliable diagnostics for high redshift galaxies. Our measurements suggest that offsets in emission line ratios at high redshift are primarily caused by high N/O abundance ratios. However, our ground-based data cannot rule out other interpretations. Spatially resolved Hubble grism spectra are needed to distinguish between the remaining plausible causes such as active nuclei, shocks, diffuse ionized gas emission, and HII regions with escaping ionizing flux. Identifying the physical origin of evolving excitation will allow us to build the necessary foundation for accurate measurements of metallicity and other properties of high redshift galaxies. Only then can we expoit the wealth of data from current surveys and near-future JWST spectroscopy to understand how galaxies evolve over time.

Radial resolution enhancement of the NSTX Thomson scattering diagnostic.

PubMed

LeBlanc, B P; Diallo, A; Labik, G; Stevens, D R

2012-10-01

Current magnetic confinement plasma physics research has increased the demand for radial resolution in profile diagnostics, in particular in the edge and pedestal regions. On NSTX, an upgrade of the existing multi-point Thomson scattering diagnostic has been implemented in order to respond to the research program needs. Twelve new radial channels have been added bringing the total number of positions to 42. Four previously un-instrumented fiber bundles were put in service. Eight existing "active" fiber bundles were divided in two sub-bundles each in order to increase spatial resolution. Twelve radial channels now cover the pedestal region with a resolution near one centimeter. Fifteen radial channels cover the core and internal transport barrier regions. Two additional channels were added, one near the inner edge and one in the outer scrape-off layer. The intersection of the focused viewing optics field of view with a finite-width laser beam results in major-radius cross talk between adjacent fiber sub-bundles. A discussion and calculation of the cross talk will be presented.

Optic for an endoscope/borescope having high resolution and narrow field of view

DOEpatents

Stone, Gary F.; Trebes, James E.

2003-10-28

An optic having optimized high spatial resolution, minimal nonlinear magnification distortion while at the same time having a limited chromatic focal shift or chromatic aberrations. The optic located at the distal end of an endoscopic inspection tool permits a high resolution, narrow field of view image for medical diagnostic applications, compared to conventional optics for endoscopic instruments which provide a wide field of view, low resolution image. The image coverage is over a narrow (<20 degrees) field of view with very low optical distortion (<5% pin cushion or barrel distortion. The optic is also optimized for best color correction as well as to aid medical diagnostics.

High-resolution 3D MR spectroscopic imaging of the prostate at 3 T with the MLEV-PRESS sequence.

PubMed

Chen, Albert P; Cunningham, Charles H; Kurhanewicz, John; Xu, Duan; Hurd, Ralph E; Pauly, John M; Carvajal, Lucas; Karpodinis, Kostas; Vigneron, Daniel B

2006-09-01

A 3 T MLEV-point-resolved spectroscopy (PRESS) sequence employing optimized spectral-spatial and very selective outer-voxel suppression pulses was tested in 25 prostate cancer patients. At an echo time of 85 ms, the MLEV-PRESS sequence resulted in maximally upright inner resonances and minimal outer resonances of the citrate doublet of doublets. Magnetic resonance spectroscopic imaging (MRSI) exams performed at both 3 and 1.5 T for 10 patients demonstrated a 2.08+/-0.36-fold increase in signal-to-noise ratio (SNR) at 3 T as compared with 1.5 T for the center citrate resonances. This permitted the acquisition of MRSI data with a nominal spatial resolution of 0.16 cm3 at 3 T with similar SNR as the 0.34-cm3 data acquired at 1.5 T. Due to the twofold increase in spectral resolution at 3 T and the improved magnetic field homogeneity provided by susceptibility-matched endorectal coils, the choline resonance was better resolved from polyamine and creatine resonances as compared with 1.5 T spectra. In prostate cancer patients, the elevation of choline and the reduction of polyamines were more clearly observed at 3 T, as compared with 1.5 T MRSI. The increased SNR and corresponding spatial resolution obtainable at 3 T reduced partial volume effects and allowed improved detection of the presence and extent of abnormal metabolite levels in prostate cancer patients, as compared with 1.5 T MRSI.

Automated frame selection process for high-resolution microendoscopy

NASA Astrophysics Data System (ADS)

Ishijima, Ayumu; Schwarz, Richard A.; Shin, Dongsuk; Mondrik, Sharon; Vigneswaran, Nadarajah; Gillenwater, Ann M.; Anandasabapathy, Sharmila; Richards-Kortum, Rebecca

2015-04-01

We developed an automated frame selection algorithm for high-resolution microendoscopy video sequences. The algorithm rapidly selects a representative frame with minimal motion artifact from a short video sequence, enabling fully automated image analysis at the point-of-care. The algorithm was evaluated by quantitative comparison of diagnostically relevant image features and diagnostic classification results obtained using automated frame selection versus manual frame selection. A data set consisting of video sequences collected in vivo from 100 oral sites and 167 esophageal sites was used in the analysis. The area under the receiver operating characteristic curve was 0.78 (automated selection) versus 0.82 (manual selection) for oral sites, and 0.93 (automated selection) versus 0.92 (manual selection) for esophageal sites. The implementation of fully automated high-resolution microendoscopy at the point-of-care has the potential to reduce the number of biopsies needed for accurate diagnosis of precancer and cancer in low-resource settings where there may be limited infrastructure and personnel for standard histologic analysis.

Participants' barriers to diagnostic resolution and factors associated with needing patient navigation.

PubMed

Krok-Schoen, Jessica L; Brewer, Brittany M; Young, Gregory S; Weier, Rory C; Tatum, Cathy M; DeGraffinreid, Cecilia R; Paskett, Electra D

2015-08-15

Patient navigation (PN) may improve cancer care by identifying and removing patient-reported barriers to care. In 2012, the American College of Surgeons Commission on Cancer (CoC) announced that health care facilities seeking CoC accreditation must have PN processes in place by January 1, 2015. Given these unfunded mandates, hospitals are looking for cost-effective ways to implement PN. This study examined demographic and psychosocial predictors of barriers to diagnostic resolution among individuals with a cancer screening abnormality enrolled in the Ohio Patient Navigation Research Project. Data were obtained from patients who received care at 1 of 9 Ohio Patient Navigation Research Project intervention clinics. Descriptive statistics and logistic regression models were used. There were 424 participants, and 151 (35.6%) reported a barrier to diagnostic resolution within 90 days of study consent. The most commonly reported barriers were misconceptions about a test or treatment (16.4%), difficulty in communicating with the provider (15.0%), and scheduling problems (11.5%). Univariate analyses indicated that race, education, employment, income, insurance, clinic type, friend support, and physical and psychological functioning were significantly associated with reporting a barrier to diagnostic resolution. Multivariate analyses found that comorbidities (odds ratio, 1.65; 95% confidence interval, 1.04-2.61) and higher intrusive thoughts and feelings (odds ratio, 1.25; 95% confidence interval, 1.10-1.41) were significantly associated with reporting a barrier to diagnostic resolution. The results suggest that demographic and psychosocial factors are associated with barriers to diagnostic resolution. To ensure compliance with the CoC mandate and provide timely care to all patients, CoC-accredited facilities can systematically identify the patients most likely to have barriers to care and assign them to PN. © 2015 American Cancer Society.

Efficient design and verification of diagnostics for impurity transport experiments.

PubMed

Chilenski, M A; Greenwald, M J; Marzouk, Y M; Rice, J E; White, A E

2018-01-01

Recent attempts to measure impurity transport in Alcator C-Mod using an x-ray imaging crystal spectrometer and laser blow-off impurity injector have failed to yield unique reconstructions of the transport coefficient profiles. This paper presents a fast, linearized model which was constructed to estimate diagnostic requirements for impurity transport experiments. The analysis shows that the spectroscopic diagnostics on Alcator C-Mod should be capable of inferring simple profiles of impurity diffusion D Z and convection V Z accurate to better than ±10% uncertainty, suggesting that the failure to infer unique D Z and V Z from experimental data is attributable to an inadequate analysis procedure rather than the result of insufficient diagnostics. Furthermore, the analysis reveals that even a modest spatial resolution can overcome a low time resolution. This approach can be adapted to design and verify diagnostics for transport experiments on any magnetic confinement device.

High-resolution threshold photoionization of N2O

NASA Technical Reports Server (NTRS)

Wiedmann, R. T.; Grant, E. R.; Tonkyn, R. G.; White, M. G.

1991-01-01

Pulsed field ionization (PFI) has been used in conjunction with a coherent VUV source to obtain high-resolution threshold photoelectron spectra for the (000), (010), (020), and (100) vibrational states of the N2O(+) cation. Simulations for the rotational profiles of each vibronic level were obtained by fitting the Buckingham-Orr-Sichel equations using accurate spectroscopic constants for the ground states of the neutral and the ion. The relative branch intensities are interpreted in terms of the partial waves of the outgoing photoelectron to which the ionic core is coupled and in terms of the angular momentum transferred to the core.

Spectroscopic database

NASA Technical Reports Server (NTRS)

Husson, N.; Barbe, A.; Brown, L. R.; Carli, B.; Goldman, A.; Pickett, H. M.; Roche, A. E.; Rothman, L. S.; Smith, M. A. H.

1985-01-01

Several aspects of quantitative atmospheric spectroscopy are considered, using a classification of the molecules according to the gas amounts in the stratosphere and upper troposphere, and reviews of quantitative atmospheric high-resolution spectroscopic measurements and field measurements systems are given. Laboratory spectroscopy and spectral analysis and prediction are presented with a summary of current laboratory spectroscopy capabilities. Spectroscopic data requirements for accurate derivation of atmospheric composition are discussed, where examples are given for space-based remote sensing experiments of the atmosphere: the ATMOS (Atmospheric Trace Molecule) and UARS (Upper Atmosphere Research Satellite) experiment. A review of the basic parameters involved in the data compilations; a summary of information on line parameter compilations already in existence; and a summary of current laboratory spectroscopy studies are used to assess the data base.

Ultrasound-aided high-resolution biophotonic imaging

NASA Astrophysics Data System (ADS)

Wang, Lihong V.

2003-10-01

We develop novel biophotonic imaging for early-cancer detection, a grand challenge in cancer research, using nonionizing electromagnetic and ultrasonic waves. Unlike ionizing x-ray radiation, nonionizing electromagnetic waves such as optical waves are safe for biomedical applications and reveal new contrast mechanisms and functional information. For example, our spectroscopic oblique-incidence reflectometry can detect skin cancers based on functional hemoglobin parameters and cell nuclear size with 95% accuracy. Unfortunately, electromagnetic waves in the nonionizing spectral region do not penetrate biological tissue in straight paths as do x-rays. Consequently, high-resolution tomography based on nonionizing electromagnetic waves alone, as demonstrated by our Mueller optical coherence tomography, is limited to superficial tissue imaging. Ultrasonic imaging, on the contrary, furnishes good imaging resolution but has poor contrast in early-stage tumors and has strong speckle artifacts as well. We developed ultrasound-mediated imaging modalities by combining electromagnetic and ultrasonic waves synergistically. The hybrid modalities yield speckle-free electromagnetic-contrast at ultrasonic resolution in relatively large biological tissue. In ultrasound-modulated (acousto)-optical tomography, a focused ultrasonic wave encodes diffuse laser light in scattering biological tissue. In photo-acoustic (thermo-acoustic) tomography, a low-energy laser (RF) pulse induces ultrasonic waves in biological tissue due to thermoelastic expansion.

Helium temperature measurements in a hot filament magnetic mirror plasma using high resolution Doppler spectroscopy

NASA Astrophysics Data System (ADS)

Knott, S.; McCarthy, P. J.; Ruth, A. A.

2016-09-01

Langmuir probe and spectroscopic diagnostics are used to routinely measure electron temperature and density over a wide operating range in a reconfigured Double Plasma device at University College Cork, Ireland. The helium plasma, generated through thermionic emission from a negatively biased tungsten filament, is confined by an axisymmetric magnetic mirror configuration using two stacks of NdFeB permanent magnets, each of length 20 cm and diameter 3 cm placed just outside the 15 mm water cooling jacket enclosing a cylindrical vacuum vessel of internal diameter 25 cm. Plasma light is analysed using a Fourier Transform-type Bruker spectrometer with a highest achievable resolution of 0.08 cm-1 . In the present work, the conventional assumption of room temperature ions in the analysis of Langmuir probe data from low temperature plasmas is examined critically using Doppler spectroscopy of the 468.6 nm He II line. Results for ion temperatures obtained from spectroscopic data for a variety of engineering parameters (discharge voltage, gas pressure and plasma current) will be presented.

High-resolution ultrasonography in assessing temporomandibular joint disc position.

PubMed

Talmaceanu, Daniel; Lenghel, Lavinia Manuela; Bolog, Nicolae; Popa Stanila, Roxana; Buduru, Smaranda; Leucuta, Daniel Corneliu; Rotar, Horatiu; Baciut, Mihaela; Baciut, Grigore

2018-02-04

The purpose of this study was to determine the diagnostic value of high-resolution ultrasonography (US) in temporomandibular joint (TMJ) disc displacements. A number of 74 patients (148 TMJs) with signs and symptoms of TMJ disorders, according to the Research Diagnostic Criteria for Temporomandibular Disorders, were included in this study. All patients received US and magnetic resonance imaging (MRI) of both TMJs 1 to 5 days after the clinical examination. MRI examinations were performed using 1.5 T MRI equipment (Siemens Avanto, Siemens, Erlangen). Ultrasonographic examination was performed on a Hitachi EUB 8500 (Hitachi Medical Corp., Tokyo, Japan) scanner with L 54 M6.5-13 MHz linear transducer. MRI depicted 68 (45.95%) normal joints, 47 (31.76%) with disc displacement with reduction, 33 (22.3%) with disc displacement without reduction and 34 (22.97%) with degenerative changes. US detected 78 (52.7%) normal joints, 37 (25%) with disc displacement with reduction, 33 (22.3%) with disc displacement without reduction and 21 (14.19%) with degenerative changes. Compared to MRI, US showed a sensitivity of 93.1%, specificity of 87.88%, accuracy of 90.32%, a positive predictive value of 87.1% and a negative predictive value of 93.55% for overall diagnosis of disc displacement. The Youden index was 0.81. Based on our results, high-resolution ultrasonography showed high sensitivity, specificity and accuracy in the diagnosis of TMJ disc displacement. It could be a valuable imaging technique in assessing TMJ disc position. The diagnostic value of high-resolution ultrasonography depends strictly on the examiner's skills and on the equipment used.

Spectroscopic imaging of limiter heat and particle fluxes and the resulting impurity sources during Wendelstein 7-X startup plasmas

DOE PAGES

Stephey, L.; Wurden, G. A.; Schmitz, O.; ...

2016-08-08

A combined IR and visible camera system [G. A. Wurden et al., “A high resolution IR/visible imaging system for the W7-X limiter,” Rev. Sci. Instrum. (these proceedings)] and a filterscope system [R. J. Colchin et al., Rev. Sci. Instrum. 74, 2068 (2003)] were implemented together to obtain spectroscopic data of limiter and first wall recycling and impurity sources during Wendelstein 7-X startup plasmas. Both systems together provided excellent temporal and spatial spectroscopic resolution of limiter 3. Narrowband interference filters in front of the camera yielded C-III and Hα photon flux, and the filterscope system provided H α, H β, He-I,more » He-II, C-II, and visible bremsstrahlung data. The filterscopes made additional measurements of several points on the W7-X vacuum vessel to yield wall recycling fluxes. Finally, the resulting photon flux from both the visible camera and filterscopes can then be compared to an EMC3-EIRENE synthetic diagnostic [H. Frerichs et al., “Synthetic plasma edge diagnostics for EMC3-EIRENE, highlighted for Wendelstein 7-X,” Rev. Sci. Instrum. (these proceedings)] to infer both a limiter particle flux and wall particle flux, both of which will ultimately be used to infer the complete particle balance and particle confinement time τ P.« less

A High Resolution Spectroscopic Observation of CAL 83 with XMM-Newton/RGS

NASA Technical Reports Server (NTRS)

Paerels, Frits; Rasmussen, Andrew P.; Hartmann, H. W.; Heise, J.; Brinkman, A. C.; deVries, C. P.; denHerder, J.-W.

2000-01-01

We present the first high resolution photospheric X-ray spectrum of a Supersoft X-ray Source, the famous CAL 83 in the Large Magellanic Cloud. The spectrum was obtained with the Reflection Grating Spectrometer on XMM-Newton during the Calibration/Performance Verification phase of the observatory. The spectrum covers the range 20-40 A at an approximately constant resolution of 0.05 A, and shows very significant, intricate detail, that is very sensitive to the physical properties of the object. We present the results of an initial investigation of the spectrum, from which we draw the conclusion that the spectral structure is probably dominated by numerous absorption features due to transitions in the Gshells of the mid-2 elements and the M-shell of Fe, in addition to a few strong K-shell features due to CNO.

High-resolution ionization detector and array of such detectors

DOEpatents

McGregor, Douglas S [Ypsilanti, MI; Rojeski, Ronald A [Pleasanton, CA

2001-01-16

A high-resolution ionization detector and an array of such detectors are described which utilize a reference pattern of conductive or semiconductive material to form interaction, pervious and measurement regions in an ionization substrate of, for example, CdZnTe material. The ionization detector is a room temperature semiconductor radiation detector. Various geometries of such a detector and an array of such detectors produce room temperature operated gamma ray spectrometers with relatively high resolution. For example, a 1 cm.sup.3 detector is capable of measuring .sup.137 Cs 662 keV gamma rays with room temperature energy resolution approaching 2% at FWHM. Two major types of such detectors include a parallel strip semiconductor Frisch grid detector and the geometrically weighted trapezoid prism semiconductor Frisch grid detector. The geometrically weighted detector records room temperature (24.degree. C.) energy resolutions of 2.68% FWHM for .sup.137 Cs 662 keV gamma rays and 2.45% FWHM for .sup.60 Co 1.332 MeV gamma rays. The detectors perform well without any electronic pulse rejection, correction or compensation techniques. The devices operate at room temperature with simple commercially available NIM bin electronics and do not require special preamplifiers or cooling stages for good spectroscopic results.

A multiresolution approach for the convergence acceleration of multivariate curve resolution methods.

PubMed

Sawall, Mathias; Kubis, Christoph; Börner, Armin; Selent, Detlef; Neymeyr, Klaus

2015-09-03

Modern computerized spectroscopic instrumentation can result in high volumes of spectroscopic data. Such accurate measurements rise special computational challenges for multivariate curve resolution techniques since pure component factorizations are often solved via constrained minimization problems. The computational costs for these calculations rapidly grow with an increased time or frequency resolution of the spectral measurements. The key idea of this paper is to define for the given high-dimensional spectroscopic data a sequence of coarsened subproblems with reduced resolutions. The multiresolution algorithm first computes a pure component factorization for the coarsest problem with the lowest resolution. Then the factorization results are used as initial values for the next problem with a higher resolution. Good initial values result in a fast solution on the next refined level. This procedure is repeated and finally a factorization is determined for the highest level of resolution. The described multiresolution approach allows a considerable convergence acceleration. The computational procedure is analyzed and is tested for experimental spectroscopic data from the rhodium-catalyzed hydroformylation together with various soft and hard models. Copyright © 2015 Elsevier B.V. All rights reserved.

Compartmentalized Low-Rank Recovery for High-Resolution Lipid Unsuppressed MRSI

PubMed Central

Bhattacharya, Ipshita; Jacob, Mathews

2017-01-01

Purpose To introduce a novel algorithm for the recovery of high-resolution magnetic resonance spectroscopic imaging (MRSI) data with minimal lipid leakage artifacts, from dual-density spiral acquisition. Methods The reconstruction of MRSI data from dual-density spiral data is formulated as a compartmental low-rank recovery problem. The MRSI dataset is modeled as the sum of metabolite and lipid signals, each of which is support limited to the brain and extracranial regions, respectively, in addition to being orthogonal to each other. The reconstruction problem is formulated as an optimization problem, which is solved using iterative reweighted nuclear norm minimization. Results The comparisons of the scheme against dual-resolution reconstruction algorithm on numerical phantom and in vivo datasets demonstrate the ability of the scheme to provide higher spatial resolution and lower lipid leakage artifacts. The experiments demonstrate the ability of the scheme to recover the metabolite maps, from lipid unsuppressed datasets with echo time (TE)=55 ms. Conclusion The proposed reconstruction method and data acquisition strategy provide an efficient way to achieve high-resolution metabolite maps without lipid suppression. This algorithm would be beneficial for fast metabolic mapping and extension to multislice acquisitions. PMID:27851875

Diamond anvil cell for spectroscopic investigation of materials at high temperature, high pressure and shear

DOEpatents

Westerfield, Curtis L.; Morris, John S.; Agnew, Stephen F.

1997-01-01

Diamond anvil cell for spectroscopic investigation of materials at high temperature, high pressure and shear. A cell is described which, in combination with Fourier transform IR spectroscopy, permits the spectroscopic investigation of boundary layers under conditions of high temperature, high pressure and shear.

Spectroscopic imaging of biomaterials and biological systems with FTIR microscopy or with quantum cascade lasers.

PubMed

Kimber, James A; Kazarian, Sergei G

2017-10-01

Spectroscopic imaging of biomaterials and biological systems has received increased interest within the last decade because of its potential to aid in the detection of disease using biomaterials/biopsy samples and to probe the states of live cells in a label-free manner. The factors behind this increased attention include the availability of improved infrared microscopes and systems that do not require the use of a synchrotron as a light source, as well as the decreasing costs of these systems. This article highlights the current technical challenges and future directions of mid-infrared spectroscopic imaging within this field. Specifically, these are improvements in spatial resolution and spectral quality through the use of novel added lenses and computational algorithms, as well as quantum cascade laser imaging systems, which offer advantages over traditional Fourier transform infrared systems with respect to the speed of acquisition and field of view. Overcoming these challenges will push forward spectroscopic imaging as a viable tool for disease diagnostics and medical research. Graphical abstract Absorbance images of a biopsy obtained using an FTIR imaging microscope with and without an added lens, and also using a QCL microscope with high-NA objective.

High-resolution typing of Chlamydia trachomatis: epidemiological and clinical uses.

PubMed

de Vries, Henry J C; Schim van der Loeff, Maarten F; Bruisten, Sylvia M

2015-02-01

A state-of-the-art overview of molecular Chlamydia trachomatis typing methods that are used for routine diagnostics and scientific studies. Molecular epidemiology uses high-resolution typing techniques such as multilocus sequence typing, multilocus variable number of tandem repeats analysis, and whole-genome sequencing to identify strains based on their DNA sequence. These data can be used for cluster, network and phylogenetic analyses, and are used to unveil transmission networks, risk groups, and evolutionary pathways. High-resolution typing of C. trachomatis strains is applied to monitor treatment efficacy and re-infections, and to study the recent emergence of lymphogranuloma venereum (LGV) amongst men who have sex with men in high-income countries. Chlamydia strain typing has clinical relevance in disease management, as LGV needs longer treatment than non-LGV C. trachomatis. It has also led to the discovery of a new variant Chlamydia strain in Sweden, which was not detected by some commercial C. trachomatis diagnostic platforms. After a brief history and comparison of the various Chlamydia typing methods, the applications of the current techniques are described and future endeavors to extend scientific understanding are formulated. High-resolution typing will likely help to further unravel the pathophysiological mechanisms behind the wide clinical spectrum of chlamydial disease.

High resolution, MRI-based, segmented, computerized head phantom

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zubal, I.G.; Harrell, C.R.; Smith, E.O.

1999-01-01

The authors have created a high-resolution software phantom of the human brain which is applicable to voxel-based radiation transport calculations yielding nuclear medicine simulated images and/or internal dose estimates. A software head phantom was created from 124 transverse MRI images of a healthy normal individual. The transverse T2 slices, recorded in a 256x256 matrix from a GE Signa 2 scanner, have isotropic voxel dimensions of 1.5 mm and were manually segmented by the clinical staff. Each voxel of the phantom contains one of 62 index numbers designating anatomical, neurological, and taxonomical structures. The result is stored as a 256x256x128 bytemore » array. Internal volumes compare favorably to those described in the ICRP Reference Man. The computerized array represents a high resolution model of a typical human brain and serves as a voxel-based anthropomorphic head phantom suitable for computer-based modeling and simulation calculations. It offers an improved realism over previous mathematically described software brain phantoms, and creates a reference standard for comparing results of newly emerging voxel-based computations. Such voxel-based computations lead the way to developing diagnostic and dosimetry calculations which can utilize patient-specific diagnostic images. However, such individualized approaches lack fast, automatic segmentation schemes for routine use; therefore, the high resolution, typical head geometry gives the most realistic patient model currently available.« less

Diamond anvil cell for spectroscopic investigation of materials at high temperature, high pressure and shear

DOEpatents

Westerfield, C.L.; Morris, J.S.; Agnew, S.F.

1997-01-14

Diamond anvil cell is described for spectroscopic investigation of materials at high temperature, high pressure and shear. A cell is described which, in combination with Fourier transform IR spectroscopy, permits the spectroscopic investigation of boundary layers under conditions of high temperature, high pressure and shear. 4 figs.

High resolution spectroscopy of six new extreme helium stars

NASA Technical Reports Server (NTRS)

Heber, U.; Jones, G.; Drilling, J. S.

1986-01-01

High resolution spectra of six newly discovered extreme helium stars are presented. LSS 5121 is shown to be a spectroscopical twin of the hot extreme helium star HD 160641. A preliminary LTE analysis of LSS 3184 yielded an effective temperature of 22,000 K and a surface gravity of log g = 3.2. Four stars form a new subgroup, classified by sharp-lined He I spectra and pronounced O II spectra, and it is conjectured that these lie close to the Eddington limit. The whole group of extreme helium stars apparently is inhomogeneous with respect to luminosity to mass ratio and chemical composition.

Diagnostic applications of an optoelectronic device for high temporal resolution of erythrocyte sedimentation (ESR-graphy)

NASA Astrophysics Data System (ADS)

Voeikov, Vladimir L.; Buravleva, Ekaterina; Bulargina, Yulia; Gurfinkel, Youri I.

2001-10-01

An automatic device for high-temporal resolution of the process of erythrocytes sedimentation in blood was designed. The position of the boundary between red blood and plasma is registered each 30 sec in several pipettes simultaneously with +/- 10 mkm precision. Data are processed by a PC and presented as velocity-time curves (ESR-grams) and the curves describing time evolution of the boundary position. ESR-grams demonstrate non-monotonous character of erythrocytes sedimentation in blood. Blood of particular donor being in a stable physiological state taken on different days is characterized by similar ESR-grams. Pathological deviations from a normal physiological state are reflected in the shortening of duration of each process stage and increasing of average sedimentation rate. Intravenous infusion of some medical preparations may lead either to improving (prolonging of macrokinetic stages, decreasing of sedimentation rate), or to worsening of studied parameters depending on an individual. The low extent of blood dilution with saline in vitro lead as a rule to decreasing of sedimentation rate and improving of microkinetic parameters of the process. Adding of highly diluted hydrogen peroxide to blood samples of patients resulted in the improving of sedimentation kinetics. ESR-graphy may widen opportunities of practical medicine in diagnostics, prognostics and drug therapy.

O-space with high resolution readouts outperforms radial imaging.

PubMed

Wang, Haifeng; Tam, Leo; Kopanoglu, Emre; Peters, Dana C; Constable, R Todd; Galiana, Gigi

2017-04-01

While O-Space imaging is well known to accelerate image acquisition beyond traditional Cartesian sampling, its advantages compared to undersampled radial imaging, the linear trajectory most akin to O-Space imaging, have not been detailed. In addition, previous studies have focused on ultrafast imaging with very high acceleration factors and relatively low resolution. The purpose of this work is to directly compare O-Space and radial imaging in their potential to deliver highly undersampled images of high resolution and minimal artifacts, as needed for diagnostic applications. We report that the greatest advantages to O-Space imaging are observed with extended data acquisition readouts. A sampling strategy that uses high resolution readouts is presented and applied to compare the potential of radial and O-Space sequences to generate high resolution images at high undersampling factors. Simulations and phantom studies were performed to investigate whether use of extended readout windows in O-Space imaging would increase k-space sampling and improve image quality, compared to radial imaging. Experimental O-Space images acquired with high resolution readouts show fewer artifacts and greater sharpness than radial imaging with equivalent scan parameters. Radial images taken with longer readouts show stronger undersampling artifacts, which can cause small or subtle image features to disappear. These features are preserved in a comparable O-Space image. High resolution O-Space imaging yields highly undersampled images of high resolution and minimal artifacts. The additional nonlinear gradient field improves image quality beyond conventional radial imaging. Copyright © 2016 Elsevier Inc. All rights reserved.

Understanding reconstructed Dante spectra using high resolution spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

May, M. J., E-mail: may13@llnl.gov; Widmann, K.; Kemp, G. E.

2016-11-15

The Dante is an 18 channel filtered diode array used at the National Ignition Facility (NIF) to measure the spectrally and temporally resolved radiation flux between 50 eV and 20 keV from various targets. The absolute flux is determined from the radiometric calibration of the x-ray diodes, filters, and mirrors and a reconstruction algorithm applied to the recorded voltages from each channel. The reconstructed spectra are very low resolution with features consistent with the instrument response and are not necessarily consistent with the spectral emission features from the plasma. Errors may exist between the reconstructed spectra and the actual emissionmore » features due to assumptions in the algorithm. Recently, a high resolution convex crystal spectrometer, VIRGIL, has been installed at NIF with the same line of sight as the Dante. Spectra from L-shell Ag and Xe have been recorded by both VIRGIL and Dante. Comparisons of these two spectroscopic measurements yield insights into the accuracy of the Dante reconstructions.« less

Characteristics of laser-induced plasma as a spectroscopic light emission source

NASA Astrophysics Data System (ADS)

Ma, Q. L.; Motto-Ros, V.; Lei, W. Q.; Wang, X. C.; Boueri, M.; Laye, F.; Zeng, C. Q.; Sausy, M.; Wartelle, A.; Bai, X. S.; Zheng, L. J.; Zeng, H. P.; Baudelet, M.; Yu, J.

2012-05-01

Laser-induced plasma is today a widespread spectroscopic emission source. It can be easily generated using compact and reliable nanosecond pulsed lasers and finds applications in various domains with laser-induced breakdown spectroscopy (LIBS). It is however such a particular medium which is intrinsically a transient and non-point light emitting source. Its timeand space-resolved diagnostics is therefore crucial for its optimized use. In this paper, we review our work on the investigation of the morphology and the evolution of the plasma. Different time scales relevant for the description of the plasma's kinetics and dynamics are covered by suitable techniques. Our results show detailed evolution and transformation of the plasma with high temporal and spatial resolutions. The effects of the laser parameters as well as the background gas are particularly studied.

Spectroscopic diagnostics of solar flares

NASA Astrophysics Data System (ADS)

Bely-Dubau, F.; Dubau, J.; Faucher, P.; Loulergue, M.; Steenman-Clarke, L.

Observations made with the X-ray polychromator (XRP) on board the Solar Maximum Mission satellite were analyzed. Data from the bent crystal spectrometer portion of the XRP experiment, in the spectral domain 1 to 3 A, with high spectral and temporal resolution, were used. Results for the spectrum analysis of iron are given. The possibility of polarization effects is considered. Although it is demonstrated that hyperfine analyses of a given spectrum are obtainable, provided calculations include large quantities of high precision atomic data, the interpretation is limited by the hypothesis of homogeneity of the emitting plasma.

NITROGEN ISOTOPIC RATIO OF COMETARY AMMONIA FROM HIGH-RESOLUTION OPTICAL SPECTROSCOPIC OBSERVATIONS OF C/2014 Q2 (LOVEJOY)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shinnaka, Yoshiharu; Kawakita, Hideyo, E-mail: yoshiharu.shinnaka@nao.ac.jp

The icy materials present in comets provide clues to the origin and evolution of our solar system and planetary systems. High-resolution optical spectroscopic observations of comet C/2014 Q2 (Lovejoy) were performed on 2015 January 11 (at 1.321 au pre-perihelion) with the High Dispersion Spectrograph mounted on the Subaru Telescope on Maunakea, Hawaii. We derive the {sup 14}N/{sup 15}N ratio of NH{sub 2} (126 ± 25), as well as the ortho-to-para abundance ratios (OPRs) of the H{sub 2}O{sup +} ion (2.77 ± 0.24) and NH{sub 2} (3.38 ± 0.07), which correspond to nuclear spin temperatures of >24 K (3 σ lowermore » limit) and 27 ± 2 K, respectively. We also derive the intensity ratio of the green-to-red doublet of forbidden oxygen lines (0.107 ± 0.007). The ammonia in the comet must have formed under low-temperature conditions at ∼10 K or less to reproduce the observed {sup 14}N/{sup 15}N ratio in this molecule if it is assumed that the {sup 15}N-fractionation of ammonia occurred via ion–molecule chemical reactions. However, this temperature is inconsistent with the nuclear spin temperatures of water and ammonia estimated from the OPRs. The interpretation of the nuclear spin temperature as the temperature at molecular formation may therefore be incorrect. An isotope-selective photodissociation of molecular nitrogen by protosolar ultraviolet radiation might play an important role in the {sup 15}N-fractionation observed in cometary volatiles.« less

High-resolution ultrasound imaging of the eye - a review.

PubMed

Silverman, Ronald H

2009-01-01

This report summarizes the physics, technology and clinical application of ultrasound biomicroscopy (UBM) of the eye, in which frequencies of 35 MHz and above provide over a threefold improvement in resolution compared with conventional ophthalmic ultrasound systems. UBM allows imaging of anatomy and pathology involving the anterior segment, including regions obscured by overlying optically opaque anatomic or pathologic structures. UBM provides diagnostically significant information in conditions such as glaucoma, cysts and neoplasms, trauma and foreign bodies. UBM also can provide crucial biometric information regarding anterior segment structures, including the cornea and its constituent layers and the anterior and posterior chambers. Although UBM has now been in use for over 15 years, new technologies, including transducer arrays, pulse encoding and combination of ultrasound with light, offer the potential for significant advances in high-resolution diagnostic imaging of the eye.

Global spectroscopic survey of cloud thermodynamic phase at high spatial resolution, 2005-2015

NASA Astrophysics Data System (ADS)

Thompson, David R.; Kahn, Brian H.; Green, Robert O.; Chien, Steve A.; Middleton, Elizabeth M.; Tran, Daniel Q.

2018-02-01

The distribution of ice, liquid, and mixed phase clouds is important for Earth's planetary radiation budget, impacting cloud optical properties, evolution, and solar reflectivity. Most remote orbital thermodynamic phase measurements observe kilometer scales and are insensitive to mixed phases. This under-constrains important processes with outsize radiative forcing impact, such as spatial partitioning in mixed phase clouds. To date, the fine spatial structure of cloud phase has not been measured at global scales. Imaging spectroscopy of reflected solar energy from 1.4 to 1.8 µm can address this gap: it directly measures ice and water absorption, a robust indicator of cloud top thermodynamic phase, with spatial resolution of tens to hundreds of meters. We report the first such global high spatial resolution survey based on data from 2005 to 2015 acquired by the Hyperion imaging spectrometer onboard NASA's Earth Observer 1 (EO-1) spacecraft. Seasonal and latitudinal distributions corroborate observations by the Atmospheric Infrared Sounder (AIRS). For extratropical cloud systems, just 25 % of variance observed at GCM grid scales of 100 km was related to irreducible measurement error, while 75 % was explained by spatial correlations possible at finer resolutions.

VizieR Online Data Catalog: Orphan stream high-resolution spectroscopic study (Casey+, 2014)

NASA Astrophysics Data System (ADS)

Casey, A. R.; Keller, S. C.; da Costa, G.; Frebel, A.; Maunder, E.

2017-06-01

High-resolution spectra for five Orphan stream candidates and seven well-studied standard stars have been obtained with the Magellan Inamori Kyocera Echelle spectrograph (Bernstein et al. 2003SPIE.4841.1694B) on the Magellan Clay telescope. These objects were observed in 2011 March using a 1" wide slit in mean seeing of 0.9". This slit configuration provides continuous spectral coverage from 333 nm to 915 nm, with a spectral resolution of R=25000 in the blue arm and R=28000 in the red arm. A minimum of 10 exposures of each calibration type (biases, flat fields, and diffuse flats) were observed in the afternoon of each day, with additional flat-field and Th-Ar arc lamp exposures performed throughout the night to ensure an accurate wavelength calibration. (3 data files).

High Resolution Spectroscopy to Support Atmospheric Measurements

NASA Technical Reports Server (NTRS)

Benner, D. Chris; Venkataraman, Malathy Devi

2000-01-01

The major research activities performed during the cooperative agreement enhanced our spectroscopic knowledge of molecules of atmospheric interest such as carbon dioxide, water vapor, ozone, methane, and carbon monoxide, to name a few. Measurements were made using the NASA Langley Tunable Diode Laser Spectrometer System (TDL) and several Fourier Transform Spectrometer Systems (FTS) around the globe. The results from these studies made remarkable improvements in the line positions and intensities for several molecules, particularly ozone and carbon dioxide in the 2 to 17-micrometer spectral region. Measurements of pressure broadening and pressure induced line shift coefficients and the temperature dependence of pressure broadening and pressure induced line shift coefficients for infrared transitions of ozone, methane, and water vapor were also performed. Results from these studies have been used for retrievals of stratospheric gas concentration profiles from data collected by several Upper Atmospheric Research satellite (UARS) infrared instruments as well as in the analysis of high resolution atmospheric spectra such as those acquired by space-based, ground-based, and various balloon- and aircraft-borne experiments. Our results made significant contributions in several updates of the HITRAN (HIgh resolution TRANsmission) spectral line parameters database. This database enjoys worldwide recognition in research involving diversified scientific fields.

High Resolution Spectroscopy to Support Atmospheric Measurements

NASA Technical Reports Server (NTRS)

Benner, D. Chris; Venkataraman, Malathy Devi

2000-01-01

The major research activities performed during the cooperative agreement enhanced our spectroscopic knowledge of molecules of atmospheric interest such as carbon dioxide, water vapor, ozone, methane, and carbon monoxide, to name a few. Measurements were made using the NASA Langley Tunable Diode Laser Spectrometer System (TDL) and several Fourier Transform Spectrometer Systems (FTS) around the globe. The results from these studies made remarkable improvements in the line positions and intensities for several molecules, particularly ozone and carbon dioxide in the 2 to 17-micrometer spectral region. Measurements of pressure broadening and pressure induced line shift coefficients and the temperature dependence of pressure broadening and pressure induced line shift coefficients for infrared transitions of ozone, methane, and water vapor were also performed. Results from these studies have been used for retrievals of stratospheric gas concentration profiles from data collected by several Upper Atmospheric Research satellite (UARS) infrared instruments as well as in the analysis of high resolution atmospheric spectra such as those acquired by space-based, ground-based, and various balloon-and aircraft-borne experiments. Our results made significant contributions in several updates of the HITRAN (HIgh resolution TRANsmission) spectral line parameters database. This database enjoys worldwide recognition in research involving diversified scientific fields.

Spectroscopic mode identification in gamma Doradus stars

NASA Astrophysics Data System (ADS)

Rylvia Pollard, Karen

2015-08-01

The MUSICIAN programme at the University of Canterbury has been successfully identifying frequencies and pulsation modes in many gamma Doradus stars using hundreds of precise, high resolution spectroscopic observations. This paper describes some of these frequency and mode identifications and the emerging patterns of the programme.

Analysis of high-resolution spectra from a hybrid interferometric/dispersive spectrometer

DOE PAGES

Ko, Phyllis; Scott, Jill R.; Jovanovic, Igor

2015-09-05

To fully take advantage of a low-cost, small footprint hybrid interferometric/dispersive spectrometer, a math- ematical reconstruction technique was developed to accurately capture the high-resolution and relative peak intensities from complex patterns. A Fabry-Perot etalon was coupled to a Czerny-Turner spectrometer, in- creasing spectral resolution by an order of magnitude without the commensurate increase in spectrometer size. Measurement of the industry standard Hg 313.1555/313.1844 nm doublet yielded a ratio of 0.682 with 1.8%error, which agreed well with an independent measurement and literature values. The doublet separation (29 pm), is similar to the U isotope shift (25 pm) at 424.437 nm thatmore » is of interest to monitoring nuclear nonpro-liferation activities. Additionally, the technique was applied to a LIBS measurement of the mineral cinnabar (HgS) and resulted in a ratio of 0.681. In addition, this reconstruction method could enable significantly smaller, portable high-resolution instruments with isotopic specificity, benefiting a variety of spectroscopic applications.« less

Correction of Near-infrared High-resolution Spectra for Telluric Absorption at 0.90–1.35 μm

NASA Astrophysics Data System (ADS)

Sameshima, Hiroaki; Matsunaga, Noriyuki; Kobayashi, Naoto; Kawakita, Hideyo; Hamano, Satoshi; Ikeda, Yuji; Kondo, Sohei; Fukue, Kei; Taniguchi, Daisuke; Mizumoto, Misaki; Arai, Akira; Otsubo, Shogo; Takenaka, Keiichi; Watase, Ayaka; Asano, Akira; Yasui, Chikako; Izumi, Natsuko; Yoshikawa, Tomohiro

2018-07-01

We report a method of correcting a near-infrared (0.90–1.35 μm) high-resolution (λ/Δλ ∼ 28,000) spectrum for telluric absorption using the corresponding spectrum of a telluric standard star. The proposed method uses an A0 V star or its analog as a standard star from which on the order of 100 intrinsic stellar lines are carefully removed with the help of a reference synthetic telluric spectrum. We find that this method can also be applied to feature-rich objects having spectra with heavily blended intrinsic stellar and telluric lines and present an application to a G-type giant using this approach. We also develop a new diagnostic method for evaluating the accuracy of telluric correction and use it to demonstrate that our method achieves an accuracy better than 2% for spectral parts for which the atmospheric transmittance is as low as ∼20% if telluric standard stars are observed under the following conditions: (1) the difference in airmass between the target and the standard is ≲ 0.05; and (2) that in time is less than 1 hr. In particular, the time variability of water vapor has a large impact on the accuracy of telluric correction and minimizing the difference in time from that of the telluric standard star is important especially in near-infrared high-resolution spectroscopic observation.

Capturing and displaying microscopic images used in medical diagnostics and forensic science using 4K video resolution - an application in higher education.

PubMed

Maier, Hans; de Heer, Gert; Ortac, Ajda; Kuijten, Jan

2015-11-01

To analyze, interpret and evaluate microscopic images, used in medical diagnostics and forensic science, video images for educational purposes were made with a very high resolution of 4096 × 2160 pixels (4K), which is four times as many pixels as High-Definition Video (1920 × 1080 pixels). The unprecedented high resolution makes it possible to see details that remain invisible to any other video format. The images of the specimens (blood cells, tissue sections, hair, fibre, etc.) are recorded using a 4K video camera which is attached to a light microscope. After processing, this resulted in very sharp and highly detailed images. This material was then used in education for classroom discussion. Spoken explanation by experts in the field of medical diagnostics and forensic science was also added to the high-resolution video images to make it suitable for self-study. © 2015 The Authors. Journal of Microscopy published by John Wiley & Sons Ltd on behalf of Royal Microscopical Society.

High-cadence, High-resolution Spectroscopic Observations of Herbig Stars HD 98922 and V1295 Aquila

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aarnio, Alicia N.; Monnier, John D.; Calvet, Nuria

Recent observational work has indicated that mechanisms for accretion and outflow in Herbig Ae/Be star–disk systems may differ from magnetospheric accretion (MA) as it is thought to occur in T Tauri star–disk systems. In this work, we assess the temporal evolution of spectral lines probing accretion and mass loss in Herbig Ae/Be systems and test for consistency with the MA paradigm. For two Herbig Ae/Be stars, HD 98922 (B9e) and V1295 Aql (A2e), we have gathered multi-epoch (∼years) and high-cadence (∼minutes) high-resolution optical spectra to probe a wide range of kinematic processes. Employing a line equivalent width evolution correlation metricmore » introduced here, we identify species co-evolving (indicative of common line origin) via novel visualization. We interferometrically constrain often problematically degenerate parameters, inclination and inner-disk radius, allowing us to focus on the structure of the wind, magnetosphere, and inner gaseous disk in radiative transfer models. Over all timescales sampled, the strongest variability occurs within the blueshifted absorption components of the Balmer series lines; the strength of variability increases with the cadence of the observations. Finally, high-resolution spectra allow us to probe substructure within the Balmer series’ blueshifted absorption components: we observe static, low-velocity features and time-evolving features at higher velocities. Overall, we find the observed line morphologies and variability are inconsistent with a scaled-up T Tauri MA scenario. We suggest that as magnetic field structure and strength change dramatically with increasing stellar mass from T Tauri to Herbig Ae/Be stars, so too may accretion and outflow processes.« less

The potential of high resolution melting analysis (hrma) to streamline, facilitate and enrich routine diagnostics in medical microbiology.

PubMed

Ruskova, Lenka; Raclavsky, Vladislav

2011-09-01

Routine medical microbiology diagnostics relies on conventional cultivation followed by phenotypic techniques for identification of pathogenic bacteria and fungi. This is not only due to tradition and economy but also because it provides pure culture needed for antibiotic susceptibility testing. This review focuses on the potential of High Resolution Melting Analysis (HRMA) of double-stranded DNA for future routine medical microbiology. Search of MEDLINE database for publications showing the advantages of HRMA in routine medical microbiology for identification, strain typing and further characterization of pathogenic bacteria and fungi in particular. The results show increasing numbers of newly-developed and more tailor-made assays in this field. For microbiologists unfamiliar with technical aspects of HRMA, we also provide insight into the technique from the perspective of microbial characterization. We can anticipate that the routine availability of HRMA in medical microbiology laboratories will provide a strong stimulus to this field. This is already envisioned by the growing number of medical microbiology applications published recently. The speed, power, convenience and cost effectiveness of this technology virtually predestine that it will advance genetic characterization of microbes and streamline, facilitate and enrich diagnostics in routine medical microbiology without interfering with the proven advantages of conventional cultivation.

Spectroscopic mode identification of γ Doradus stars

NASA Astrophysics Data System (ADS)

Brunsden, E.; Pollard, K. R.; Cottrell, P. L.; Wright, D. J.; Cat, P. De

2017-09-01

The g-mode pulsations in γ Doradus stars are identified using time-series colour photometry and high-resolution spectroscopy. For 22 class members the pulsational frequencies and modes are compared. Ground-based spectroscopic and photometric results show good agreement. The prevalence of (1, |1|) modes is noted and examined.

High Resolution UV Emission Spectroscopy of Molecules Excited by Electron Impact

NASA Technical Reports Server (NTRS)

James, G. K.; Ajello, J. M.; Beegle, L.; Ciocca, M.; Dziczek, D.; Kanik, I.; Noren, C.; Jonin, C.; Hansen, D.

1999-01-01

Photodissociation via discrete line absorption into predissociating Rydberg and valence states is the dominant destruction mechanism of CO and other molecules in the interstellar medium and molecular clouds. Accurate values for the rovibronic oscillator strengths of these transitions and predissociation yields of the excited states are required for input into the photochemical models that attempt to reproduce observed abundances. We report here on our latest experimental results of the electron collisional properties of CO and N2 obtained using the 3-meter high resolution single-scattering spectroscopic facility at JPL.

Skin imprinting in silica plates: a potential diagnostic methodology for leprosy using high-resolution mass spectrometry.

PubMed

Lima, Estela de Oliveira; de Macedo, Cristiana Santos; Esteves, Cibele Zanardi; de Oliveira, Diogo Noin; Pessolani, Maria Cristina Vidal; Nery, José Augusto da Costa; Sarno, Euzenir Nunes; Catharino, Rodrigo Ramos

2015-04-07

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which primarily infects macrophages and Schwann cells, affecting skin and peripheral nerves. Clinically, the most common form of identification is through the observation of anesthetic lesions on skin; however, up to 30% of infected patients may not present this clinical manifestation. Currently, the gold standard diagnostic test for leprosy is based on skin lesion biopsy, which is invasive and presents low sensibility for suspect cases. Therefore, the development of a fast, sensible and noninvasive method that identifies infected patients would be helpful for assertive diagnosis. The aim of this work was to identify lipid markers in leprosy patients directly from skin imprints, using a mass spectrometric analytical strategy. For skin imprint samples, a 1 cm(2) silica plate was gently pressed against the skin of patients or healthy volunteers. Imprinted silica lipids were extracted and submitted to direct-infusion electrospray ionization high-resolution mass spectrometry (ESI-HRMS). All samples were differentiated using a lipidomics-based data workup employing multivariate data analysis, which helped electing different lipid markers, for example, mycobacterial mycolic acids, inflammatory and apoptotic molecules were identified as leprosy patients' markers. Otherwise, phospholipids and gangliosides were pointed as healthy volunteers' skin lipid markers, according to normal skin composition. Results indicate that silica plate skin imprinting associated with ESI-HRMS is a promising fast and sensible leprosy diagnostic method. With a prompt leprosy diagnosis, an early and effective treatment could be feasible and thus the chain of leprosy transmission could be abbreviated.

A near-infrared high-resolution spectroscopic survey of bulge stars - JASMINE prestudy

NASA Astrophysics Data System (ADS)

Tsujimoto, T.; Gouda, N.; Kobayashi, N.; Yasui, C.; Kondo, S.; Minami, A.; Motohara, K.; Ikeda, Y.

2006-08-01

We are developing a new near-infrared high-resolution (R[max]= 100,000) and high-sensitive spectrograph WINERED, which is specifically customized for short NIR bands at 0.9-1.35 μm. WINERED employs the novelty in the optical system; a potable design and a warm optics without any cold stops. The planned astrometric space mission JASMINE will provide the exact positions, distances, and proper motions of the bulge stars. The missing components, the radial velocity and chemical compositions will be measured by WINERED with high accuracies (δV< 1km/s). These combined data brought by JASMINE and WINERED will certainly reveal the nature of the Galactic bulge. We plan to complete this instrument for the observation of a single object by the end of 2008 and hope to attach it to various 4-10m telescopes as a PI-type instrument. In succession, we will develop it to the design for a simultaneous multi-object spectroscopy.

High-Resolution Dual-Comb Spectroscopy with Ultra-Low Noise Frequency Combs

NASA Astrophysics Data System (ADS)

Hänsel, Wolfgang; Giunta, Michele; Beha, Katja; Perry, Adam J.; Holzwarth, R.

2017-06-01

Dual-comb spectroscopy is a powerful tool for fast broad-band spectroscopy due to the parallel interrogation of thousands of spectral lines. Here we report on the spectroscopic analysis of acetylene vapor in a pressurized gas cell using two ultra-low noise frequency combs with a repetition rate around 250 MHz. Optical referencing to a high-finesse cavity yields a sub-Hertz stability of all individual comb lines (including the virtual comb lines between 0 Hz and the carrier) and permits one to pick a small difference of repetition rate for the two frequency combs on the order of 300 Hz, thus representing an optical spectrum of 100 THz (˜3300 \\wn) within half the free spectral range (125 MHz). The transmission signal is derived straight from a photodetector and recorded with a high-resolution spectrum analyzer or digitized with a computer-controlled AD converter. The figure to the right shows a schematic of the experimental setup which is all fiber-coupled with polarization-maintaining fiber except for the spectroscopic cell. The graph on the lower right reveals a portion of the recorded radio-frequency spectrum which has been scaled to the optical domain. The location of the measured absorption coincides well with data taken from the HITRAN data base. Due to the intrinsic linewidth of all contributing comb lines, each sampling point in the transmission graph corresponds to the probing at an optical frequency with sub-Hertz resolution. This resolution is maintained in coherent wavelength conversion processes such as difference-frequency generation (DFG), sum-frequency generation (SFG) or non-linear broadening (self-phase modulation), and is therefore easily transferred to a wide spectral range from the mid infrared up to the visible spectrum.

High-resolution ultrasound imaging of the eye – a review

PubMed Central

Silverman, Ronald H

2009-01-01

This report summarizes the physics, technology and clinical application of ultrasound biomicroscopy (UBM) of the eye, in which frequencies of 35 MHz and above provide over a threefold improvement in resolution compared with conventional ophthalmic ultrasound systems. UBM allows imaging of anatomy and pathology involving the anterior segment, including regions obscured by overlying optically opaque anatomic or pathologic structures. UBM provides diagnostically significant information in conditions such as glaucoma, cysts and neoplasms, trauma and foreign bodies. UBM also can provide crucial biometric information regarding anterior segment structures, including the cornea and its constituent layers and the anterior and posterior chambers. Although UBM has now been in use for over 15 years, new technologies, including transducer arrays, pulse encoding and combination of ultrasound with light, offer the potential for significant advances in high-resolution diagnostic imaging of the eye. PMID:19138310

Inter-observer agreement for diagnostic classification of esophageal motility disorders defined in high-resolution manometry.

PubMed

Fox, M R; Pandolfino, J E; Sweis, R; Sauter, M; Abreu Y Abreu, A T; Anggiansah, A; Bogte, A; Bredenoord, A J; Dengler, W; Elvevi, A; Fruehauf, H; Gellersen, S; Ghosh, S; Gyawali, C P; Heinrich, H; Hemmink, M; Jafari, J; Kaufman, E; Kessing, K; Kwiatek, M; Lubomyr, B; Banasiuk, M; Mion, F; Pérez-de-la-Serna, J; Remes-Troche, J M; Rohof, W; Roman, S; Ruiz-de-León, A; Tutuian, R; Uscinowicz, M; Valdovinos, M A; Vardar, R; Velosa, M; Waśko-Czopnik, D; Weijenborg, P; Wilshire, C; Wright, J; Zerbib, F; Menne, D

2015-01-01

High-resolution esophageal manometry (HRM) is a recent development used in the evaluation of esophageal function. Our aim was to assess the inter-observer agreement for diagnosis of esophageal motility disorders using this technology. Practitioners registered on the HRM Working Group website were invited to review and classify (i) 147 individual water swallows and (ii) 40 diagnostic studies comprising 10 swallows using a drop-down menu that followed the Chicago Classification system. Data were presented using a standardized format with pressure contours without a summary of HRM metrics. The sequence of swallows was fixed for each user but randomized between users to avoid sequence bias. Participants were blinded to other entries. (i) Individual swallows were assessed by 18 practitioners (13 institutions). Consensus agreement (≤ 2/18 dissenters) was present for most cases of normal peristalsis and achalasia but not for cases of peristaltic dysmotility. (ii) Diagnostic studies were assessed by 36 practitioners (28 institutions). Overall inter-observer agreement was 'moderate' (kappa 0.51) being 'substantial' (kappa > 0.7) for achalasia type I/II and no lower than 'fair-moderate' (kappa >0.34) for any diagnosis. Overall agreement was somewhat higher among those that had performed >400 studies (n = 9; kappa 0.55) and 'substantial' among experts involved in development of the Chicago Classification system (n = 4; kappa 0.66). This prospective, randomized, and blinded study reports an acceptable level of inter-observer agreement for HRM diagnoses across the full spectrum of esophageal motility disorders for a large group of clinicians working in a range of medical institutions. Suboptimal agreement for diagnosis of peristaltic motility disorders highlights contribution of objective HRM metrics. © 2014 International Society for Diseases of the Esophagus.

Laser diagnostics for combustion temperature and species

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eckbreth, A.C.

1987-01-01

Laser approaches to combustion diagnostics are of considerable interest due to their remote, nonintrusive and in-situ character, unlimited temperature capability and potential for simultaneous temporal and spatial resolution, This book aims to make these powerful and important new tools in combustion research understandable. The focus of this text is on spectroscopically-based, spatially-precise laser techniques for temperature and chemical composition measurements in reacting and nonreacting flows. After introductory chapters providing a fundamental theoretical and experimental background, attention is directed to diagnostics based upon spontaneous Raman and Rayleigh scattering, coherent anti-Stokes Raman spectroscopy (CARS) and laser-induced fluorescence (LIFS). The book concludes withmore » a treatment of techniques which permit spatially-resolved measurements over an entire two-dimensional field simultaneously.« less

High-Resolution EUV Spectroscopy of White Dwarfs

NASA Astrophysics Data System (ADS)

Kowalski, Michael P.; Wood, K. S.; Barstow, M. A.

2014-01-01

We compare results of high-resolution EUV spectroscopic measurements of the isolated white dwarf G191-B2B and the binary system Feige 24 obtained with the J-PEX (Joint Plasmadynamic Experiment), which was sponsored jointly by the U.S. Naval Research Laboratory and NASA. J-PEX delivers the world's highest resolution in EUV and does so at high effective area (e.g., more effective area in a sounding rocket than is available with Chandra at adjacent energies, but in a waveband Chandra cannot reach). The capability J-PEX represents is applicable to the astrophysics of hot plasmas in stellar coronae, white dwarfs and the ISM. G191-B2B and Feige 24 are quite distinct hot white dwarf systems having in common that they are bright in the portion of the EUV where He emission features and edges occur, hence they can be exploited to probe both the stellar atmosphere and the ISM, separating those components by model-fitting that sums over all relevant (He) spectral features in the band. There is evidence from these fits that atmospheric He is being detected but the result is more conservatively cast as a pair of upper limits. We discuss how longer duration satellite observations with the same instrumentation could increase exposure to detect atmospheric He in these and other nearby hot white dwarfs.

Studies of fission fragment yields via high-resolution γ-ray spectroscopy

NASA Astrophysics Data System (ADS)

Wilson, J. N.; Lebois, M.; Qi, L.; Amador-Celdran, P.; Bleuel, D.; Briz, J. A.; Carroll, R.; Catford, W.; Witte, H. De; Doherty, D. T.; Eloirdi, R.; Georgiev, G.; Gottardo, A.; Goasduff, A.; Hadyñska-Klek, K.; Hauschild, K.; Hess, H.; Ingeberg, V.; Konstantinopoulos, T.; Ljungvall, J.; Lopez-Martens, A.; Lorusso, G.; Lozeva, R.; Lutter, R.; Marini, P.; Matea, I.; Materna, T.; Mathieu, L.; Oberstedt, A.; Oberstedt, S.; Panebianco, S.; Podolyak, Zs.; Porta, A.; Regan, P. H.; Reiter, P.; Rezynkina, K.; Rose, S. J.; Sahin, E.; Seidlitz, M.; Serot, O.; Shearman, R.; Siebeck, B.; Siem, S.; Smith, A. G.; Tveten, G. M.; Verney, D.; Warr, N.; Zeiser, F.; Zielinska, M.

2018-03-01

Precise spectroscopic information on the fast neutron induced fission of the 238U(n,f) reaction was recently gained using a new technique which involved coupling of the Miniball high resolution y-ray spectrometer and the LICORNE directional neutron source. The experiment allowed measurement of the isotopic fission yields for around 40 even-even nuclei at an incident neutron energy of around 2 MeV where yield data are very sparse. In addition spectroscopic information on very neutron-rich fission products was obtained. Results were compared to models, both the JEFF-3.1.1 data base and the GEF code, and large discrepancies for the S1 fission mode in the Sn/Mo isotope pair were discovered. This suggests that current models are overestimating the role played by spherical shell effects in fast neutron induced fission. In late 2017 and 2018 the nu-ball hybrid spectrometer will be constructed at the IPN Orsay to perform further experimental investigations with directional neutrons coupled to a powerful hybrid Ge/LaBr3 detector array. This will open up new possibilities for measurements of fission yields for fast-neutron-induced fission using the spectroscopic technique and will be complimentary to other methods being developed.

The Maunakea Spectroscopic Explorer

NASA Astrophysics Data System (ADS)

Venn, Kim; Starkenburg, Else; Martin, Nicolas; Kielty, Collin; Youakim, Kris; Arnetsen, Anke

2018-06-01

The Maunakea Spectroscopic Explorer (MSE) is an ambitious project to transform the Canada-France-Hawaii 3.6-metre telescope into an 11.25-metre facility dedicated to wide field multi-object spectroscopy. Following a successful conceptual design review of ten subsystems and the systems-level review in January 2018, MSE is preparing to move into the Preliminary Design Phase. MSE will simultaneously deploy over 3000 fibers that feed low/medium resolution spectrometers and 1000 fibers that feed high-resolution (R~40,000) spectrometers. This design is expected to revolutionize astrophysical studies requiring large spectroscopic datasets: i.e., reconstructing the Milky Way's formation history through the chemical tagging of stars, searches for the effects of dark matter on stellar streams, determination of environmental influences on galaxy formation since cosmic noon, measuring black hole masses through repeat spectroscopy of quasars, follow-up of large samples identified in other surveys (Gaia, LSST, SKA, etc.), and more. MSE will reuse a large fraction of CFHT’s existing facilities while tripling the diameter of the telescope’s primary mirror and increasing the height of the enclosure by only 10%. I will discuss the progress to date and opportunities for partnerships.

Note: Tandem Kirkpatrick-Baez microscope with sixteen channels for high-resolution laser-plasma diagnostics

NASA Astrophysics Data System (ADS)

Yi, Shengzhen; Zhang, Zhe; Huang, Qiushi; Zhang, Zhong; Wang, Zhanshan; Wei, Lai; Liu, Dongxiao; Cao, Leifeng; Gu, Yuqiu

2018-03-01

Multi-channel Kirkpatrick-Baez (KB) microscopes, which have better resolution and collection efficiency than pinhole cameras, have been widely used in laser inertial confinement fusion to diagnose time evolution of the target implosion. In this study, a tandem multi-channel KB microscope was developed to have sixteen imaging channels with the precise control of spatial resolution and image intervals. This precise control was created using a coarse assembly of mirror pairs with high-accuracy optical prisms, followed by precise adjustment in real-time x-ray imaging experiments. The multilayers coated on the KB mirrors were designed to have substantially the same reflectivity to obtain a uniform brightness of different images for laser-plasma temperature analysis. The study provides a practicable method to achieve the optimum performance of the microscope for future high-resolution applications in inertial confinement fusion experiments.

Spectroscopic Characterization of GEO Satellites with Gunma LOW Resolution Spectrograph

NASA Astrophysics Data System (ADS)

Endo, T.; Ono, H.; Hosokawa, M.; Ando, T.; Takanezawa, T.; Hashimoto, O.

The spectroscopic observation is potentially a powerful tool for understanding the Geostationary Earth Orbit (GEO) objects. We present here the results of an investigation of energy spectra of GEO satellites obtained from a groundbased optical telescope. The spectroscopic observations were made from April to June 2016 with the Gunma LOW resolution Spectrograph and imager (GLOWS) at the Gunma Astronomical Observatory (GAO) in JAPAN. The observation targets consist of eleven different satellites: two weather satellites, four communications satellites, and five broadcasting satellites. All the spectra of those GEO satellites are inferred to be solar-like. A number of well-known absorption features such as H-alpha, H-beta, Na-D,water vapor and oxygen molecules are clearly seen in thewavelength range of 4,000 - 8,000 Å. For comparison, we calculated the intensity ratio of the spectra of GEO satellites to that of the Moon which is the natural satellite of the earth. As a result, the following characteristics were obtained. 1) Some variations are seen in the strength of absorption features of water vapor and oxygen originated by the telluric atmosphere, but any other characteristic absorption features were not found. 2) For all observed satellites, the intensity ratio of the spectrum of GEO satellites decrease as a function of wavelength or to be flat. It means that the spectral reflectance of satellite materials is bluer than that of the Moon. 3) A characteristic dip at around 4,800 Å is found in all observed spectra of a weather satellite. Based on these observations, it is indicated that the characteristics of the spectrum are mainly derived from the solar panels because the apparent area of the solar cell is probably larger than that of the satellite body.

Talbot-Lau x-ray interferometry for high energy density plasma diagnostic.

PubMed

Stutman, D; Finkenthal, M

2011-11-01

High resolution density diagnostics are difficult in high energy density laboratory plasmas (HEDLP) experiments due to the scarcity of probes that can penetrate above solid density plasmas. Hard x-rays are one possible probe for such dense plasmas. We study the possibility of applying an x-ray method recently developed for medical imaging, differential phase-contrast with Talbot-Lau interferometers, for the diagnostic of electron density and small-scale hydrodynamic instabilities in HEDLP experiments. The Talbot method uses micro-periodic gratings to measure the refraction and ultra-small angle scatter of x-rays through an object and is attractive for HEDLP diagnostic due to its capability to work with incoherent and polychromatic x-ray sources such as the laser driven backlighters used for HEDLP radiography. Our paper studies the potential of the Talbot method for HEDLP diagnostic, its adaptation to the HEDLP environment, and its extension of high x-ray energy using micro-periodic mirrors. The analysis is illustrated with experimental results obtained using a laboratory Talbot interferometer. © 2011 American Institute of Physics

In vivo high-resolution cortical imaging with extended-focus optical coherence microscopy in the visible-NIR wavelength range

NASA Astrophysics Data System (ADS)

Marchand, Paul J.; Szlag, Daniel; Bouwens, Arno; Lasser, Theo

2018-03-01

Visible light optical coherence tomography has shown great interest in recent years for spectroscopic and high-resolution retinal and cerebral imaging. Here, we present an extended-focus optical coherence microscopy system operating from the visible to the near-infrared wavelength range for high axial and lateral resolution imaging of cortical structures in vivo. The system exploits an ultrabroad illumination spectrum centered in the visible wavelength range (λc = 650 nm, Δλ ˜ 250 nm) offering a submicron axial resolution (˜0.85 μm in water) and an extended-focus configuration providing a high lateral resolution of ˜1.4 μm maintained over ˜150 μm in depth in water. The system's axial and lateral resolution are first characterized using phantoms, and its imaging performance is then demonstrated by imaging the vasculature, myelinated axons, and neuronal cells in the first layers of the somatosensory cortex of mice in vivo.

LED-based near infrared sensor for cancer diagnostics

NASA Astrophysics Data System (ADS)

Bogomolov, Andrey; Ageev, Vladimir; Zabarylo, Urszula; Usenov, Iskander; Schulte, Franziska; Kirsanov, Dmitry; Belikova, Valeria; Minet, Olaf; Feliksberger, E.; Meshkovsky, I.; Artyushenko, Viacheslav

2016-03-01

Optical spectroscopic technologies are increasingly used for cancer diagnostics. Feasibility of differentiation between malignant and healthy samples of human kidney using Fluorescence, Raman, MIR and NIR spectroscopy has been recently reported . In the present work, a simplification of NIR spectroscopy method has been studied. Traditional high-resolution NIR spectrometry was replaced by an optical sensor based on a set of light-emitting diodes at selected wavelengths as light sources and a photodiode. Two prototypes of the sensor have been developed and tested using 14 in-vitro samples of seven kidney tumor patients. Statistical evaluation of results using principal component analysis and partial least-squares discriminant analysis has been performed. Despite only partial discrimination between tumor and healthy tissue achieved by the presented new technique, the results evidence benefits of LED-based near-infrared sensing used for oncological diagnostics. Publisher's Note: This paper, originally published on 4 March, 2016, was replaced with a corrected/revised version on 7 April, 2016. If you downloaded the original PDF but are unable to access the revision, please contact SPIE Digital Library Customer Service for assistance.

The Application of High Energy Resolution Green's Functions to Threat Scenario Simulation

NASA Astrophysics Data System (ADS)

Thoreson, Gregory G.; Schneider, Erich A.

2012-04-01

Radiation detectors installed at key interdiction points provide defense against nuclear smuggling attempts by scanning vehicles and traffic for illicit nuclear material. These hypothetical threat scenarios may be modeled using radiation transport simulations. However, high-fidelity models are computationally intensive. Furthermore, the range of smuggler attributes and detector technologies create a large problem space not easily overcome by brute-force methods. Previous research has demonstrated that decomposing the scenario into independently simulated components using Green's functions can simulate photon detector signals with coarse energy resolution. This paper extends this methodology by presenting physics enhancements and numerical treatments which allow for an arbitrary level of energy resolution for photon transport. As a result, spectroscopic detector signals produced from full forward transport simulations can be replicated while requiring multiple orders of magnitude less computation time.

The Liege-balloon program. [balloon-borne instruments for high-spectral resolution observations of the sun

NASA Technical Reports Server (NTRS)

Zander, R.

1974-01-01

The Liege-balloon program is intended to make high-spectral resolution observations of the sun in the near- and intermediate infrared regions not accessible from the ground. A description of the equipment, followed by a summary of the data obtained till now is presented. Except for ozone whose maximum of concentration lies near 25 Km altitude, the residual mass distribution of the other mentioned molecules decreases with altitude. This is a self-explanatory argument for carrying out spectroscopic observations from platforms transcending the densest layers of the earth's atmosphere. The Liege balloon equipment is primarily intended for very high-resolution solar observations from about 27-30 Km altitude, in all spectral regions between 1.5 and 15.0 microns, not accessible from the ground.

Comparing Magnetic Resonance Imaging and High-Resolution Dynamic Ultrasonography for Diagnosis of Plantar Plate Pathology: A Case Series.

PubMed

Donegan, Ryan J; Stauffer, Anthony; Heaslet, Michael; Poliskie, Michael

Plantar plate pathology has gained noticeable attention in recent years as an etiology of lesser metatarsophalangeal joint pain. The heightened clinical awareness has led to the need for more effective diagnostic imaging accuracy. Numerous reports have established the accuracy of both magnetic resonance imaging and ultrasonography for the diagnosis of plantar plate pathology. However, no conclusions have been made regarding which is the superior imaging modality. The present study reports a case series directly comparing high-resolution dynamic ultrasonography and magnetic resonance imaging. A multicenter retrospective comparison of magnetic resonance imaging versus high-resolution dynamic ultrasonography to evaluate plantar plate pathology with surgical confirmation was conducted. The sensitivity, specificity, and positive and negative predictive values for magnetic resonance imaging were 60%, 100%, 100%, and 33%, respectively. The overall diagnostic accuracy compared with the intraoperative findings was 66%. The sensitivity, specificity, and positive and negative predictive values for high-resolution dynamic ultrasound imaging were 100%, 100%, 100%, and 100%, respectively. The overall diagnostic accuracy compared with the intraoperative findings was 100%. The p value using Fisher's exact test for magnetic resonance imaging and high-resolution dynamic ultrasonography was p = .45, a difference that was not statistically significant. High-resolution dynamic ultrasonography had greater accuracy than magnetic resonance imaging in diagnosing lesser metatarsophalangeal joint plantar plate pathology, although the difference was not statistically significant. The present case series suggests that high-resolution dynamic ultrasonography can be considered an equally accurate imaging modality for plantar plate pathology at a potential cost savings compared with magnetic resonance imaging. Therefore, high-resolution dynamic ultrasonography warrants further investigation in

High-Definition Infrared Spectroscopic Imaging

PubMed Central

Reddy, Rohith K.; Walsh, Michael J.; Schulmerich, Matthew V.; Carney, P. Scott; Bhargava, Rohit

2013-01-01

The quality of images from an infrared (IR) microscope has traditionally been limited by considerations of throughput and signal-to-noise ratio (SNR). An understanding of the achievable quality as a function of instrument parameters, from first principals is needed for improved instrument design. Here, we first present a model for light propagation through an IR spectroscopic imaging system based on scalar wave theory. The model analytically describes the propagation of light along the entire beam path from the source to the detector. The effect of various optical elements and the sample in the microscope is understood in terms of the accessible spatial frequencies by using a Fourier optics approach and simulations are conducted to gain insights into spectroscopic image formation. The optimal pixel size at the sample plane is calculated and shown much smaller than that in current mid-IR microscopy systems. A commercial imaging system is modified, and experimental data are presented to demonstrate the validity of the developed model. Building on this validated theoretical foundation, an optimal sampling configuration is set up. Acquired data were of high spatial quality but, as expected, of poorer SNR. Signal processing approaches were implemented to improve the spectral SNR. The resulting data demonstrated the ability to perform high-definition IR imaging in the laboratory by using minimally-modified commercial instruments. PMID:23317676

High-definition infrared spectroscopic imaging.

PubMed

Reddy, Rohith K; Walsh, Michael J; Schulmerich, Matthew V; Carney, P Scott; Bhargava, Rohit

2013-01-01

The quality of images from an infrared (IR) microscope has traditionally been limited by considerations of throughput and signal-to-noise ratio (SNR). An understanding of the achievable quality as a function of instrument parameters, from first principals is needed for improved instrument design. Here, we first present a model for light propagation through an IR spectroscopic imaging system based on scalar wave theory. The model analytically describes the propagation of light along the entire beam path from the source to the detector. The effect of various optical elements and the sample in the microscope is understood in terms of the accessible spatial frequencies by using a Fourier optics approach and simulations are conducted to gain insights into spectroscopic image formation. The optimal pixel size at the sample plane is calculated and shown much smaller than that in current mid-IR microscopy systems. A commercial imaging system is modified, and experimental data are presented to demonstrate the validity of the developed model. Building on this validated theoretical foundation, an optimal sampling configuration is set up. Acquired data were of high spatial quality but, as expected, of poorer SNR. Signal processing approaches were implemented to improve the spectral SNR. The resulting data demonstrated the ability to perform high-definition IR imaging in the laboratory by using minimally-modified commercial instruments.

Performance of a Medipix3RX spectroscopic pixel detector with a high resistivity gallium arsenide sensor.

PubMed

Hamann, Elias; Koenig, Thomas; Zuber, Marcus; Cecilia, Angelica; Tyazhev, Anton; Tolbanov, Oleg; Procz, Simon; Fauler, Alex; Baumbach, Tilo; Fiederle, Michael

2015-03-01

High resistivity gallium arsenide is considered a suitable sensor material for spectroscopic X-ray imaging detectors. These sensors typically have thicknesses between a few hundred μm and 1 mm to ensure a high photon detection efficiency. However, for small pixel sizes down to several tens of μm, an effect called charge sharing reduces a detector's spectroscopic performance. The recently developed Medipix3RX readout chip overcomes this limitation by implementing a charge summing circuit, which allows the reconstruction of the full energy information of a photon interaction in a single pixel. In this work, we present the characterization of the first Medipix3RX detector assembly with a 500 μm thick high resistivity, chromium compensated gallium arsenide sensor. We analyze its properties and demonstrate the functionality of the charge summing mode by means of energy response functions recorded at a synchrotron. Furthermore, the imaging properties of the detector, in terms of its modulation transfer functions and signal-to-noise ratios, are investigated. After more than one decade of attempts to establish gallium arsenide as a sensor material for photon counting detectors, our results represent a breakthrough in obtaining detector-grade material. The sensor we introduce is therefore suitable for high resolution X-ray imaging applications.

High Resolution Spectroscopy to Support Atmospheric Measurements

NASA Technical Reports Server (NTRS)

Venkataraman, Malathy Devi

2003-01-01

Spectroscopic parameters (such as line position, intensity, broadening and shifting coefficients and their temperature dependences, line mixing coefficients etc.) for various molecular species of atmospheric interest are determined. In order to achieve these results, infrared spectra of several molecular bands are obtained using high-resolution recording instruments such as tunable diode laser spectrometer and Fourier transform spectrometers. Using sophisticated analysis routines (Multispectrum nonlinear least squares technique) these high-resolution infrared spectra are processed to determine the various spectral line parameters that are cited above. Spectra were taken using the McMath-Pierce Fourier transform spectrometer (FTS) at the National Solar Observatory on Kitt Peak, Arizona as well as the Bruker FTS at the Pacific Northwest National Laboratory (PNNL) at Richland, Washington. Most of the spectra are acquired not only at room temperature, but also at several different cold temperatures. This procedure is necessary to study the variation of the spectral line parameters as a function of temperature in order to simulate the Earth's and other planetary atmospheric environments. Depending upon the strength or weakness of the various bands recorded and analyzed, the length(s) of the absorption cells in which the gas samples under study are kept varied from a few centimeters up to several meters and the sample temperatures varied from approximately +30 C to -63 C. Research on several infrared bands of various molecular species and their isotopomers are undertaken. Those studies are briefly described.

Peripheral Vasculature: High-Temporal- and High-Spatial-Resolution Three-dimensional Contrast-enhanced MR Angiography1

PubMed Central

Haider, Clifton R.; Glockner, James F.; Stanson, Anthony W.; Riederer, Stephen J.

2009-01-01

Purpose: To prospectively evaluate the feasibility of performing high-spatial-resolution (1-mm isotropic) time-resolved three-dimensional (3D) contrast material–enhanced magnetic resonance (MR) angiography of the peripheral vasculature with Cartesian acquisition with projection-reconstruction–like sampling (CAPR) and eightfold accelerated two-dimensional (2D) sensitivity encoding (SENSE). Materials and Methods: All studies were approved by the institutional review board and were HIPAA compliant; written informed consent was obtained from all participants. There were 13 volunteers (mean age, 41.9; range, 27–53 years). The CAPR sequence was adapted to provide 1-mm isotropic spatial resolution and a 5-second frame time. Use of different receiver coil element sizes for those placed on the anterior-to-posterior versus left-to-right sides of the field of view reduced signal-to-noise ratio loss due to acceleration. Results from eight volunteers were rated independently by two radiologists according to prominence of artifact, arterial to venous separation, vessel sharpness, continuity of arterial signal intensity in major arteries (anterior and posterior tibial, peroneal), demarcation of origin of major arteries, and overall diagnostic image quality. MR angiographic results in two patients with peripheral vascular disease were compared with their results at computed tomographic angiography. Results: The sequence exhibited no image artifact adversely affecting diagnostic image quality. Temporal resolution was evaluated to be sufficient in all cases, even with known rapid arterial to venous transit. The vessels were graded to have excellent sharpness, continuity, and demarcation of the origins of the major arteries. Distal muscular branches and the communicating and perforating arteries were routinely seen. Excellent diagnostic quality rating was given for 15 (94%) of 16 evaluations. Conclusion: The feasibility of performing high-diagnostic-quality time-resolved 3D

Spectroscopic Instrumentation in Undergraduate Astronomy Laboratories

NASA Astrophysics Data System (ADS)

Ludovici, Dominic; Mutel, Robert Lucien; Lang, Cornelia C.

2017-01-01

We have designed and built two spectrographs for use in undergraduate astronomy laboratories at the University of Iowa. The first, a low cost (appx. $500) low resolution (R ~ 150 - 300) grating-prism (grism) spectrometer consists of five optical elements and is easily modified to other telescope optics. The grism spectrometer is designed to be used in a modified filter wheel. This type of spectrometer allows students to undertake projects requiring sensitive spectral measurements, such as determining the redshifts of quasars. The second instrument is a high resolution (R ~ 8000), moderate cost (appx. $5000) fiber fed echelle spectrometer. The echelle spectrometer will allow students to conduct Doppler measurements such as those used to study spectroscopic binaries. Both systems are designed to be used with robotic telescope systems. The availability of 3D printing enables both of these spectrographs to be constructed in hands-on instrumentation courses where students build and commission their own instruments. Additionally, these instruments enable introductory majors and non-majors laboratory students to gain experience conducting their own spectroscopic observations.

Synthesis, high-resolution NMR spectroscopic analysis, and single-crystal X-ray diffraction of isoxazoline tetracycles.

PubMed

Fascio, Mirta L; Alvarez-Larena, Angel; D'Accorso, Norma B

2002-11-29

Three isoxazoline tetracycles were obtained enantiomerically pure by intramolecular 1,3-dipolar cycloaddition. The characterization of the new compounds was performed by high-resolution 1H and 13C NMR spectroscopy. The relative configuration of the new chiral centers was determined by NOESY experiments and confirmed by single-crystal X-ray structural analysis.

Electronic relaxation effects in condensed polyacenes: A high-resolution photoemission study

NASA Astrophysics Data System (ADS)

Rocco, M. L. M.; Haeming, M.; Batchelor, D. R.; Fink, R.; Schöll, A.; Umbach, E.

2008-08-01

We present a high-resolution photoelectron spectroscopy investigation of condensed films of benzene, naphthalene, anthracene, tetracene, and pentacene. High spectroscopic resolution and a systematic variation of the molecular size allow a detailed analysis of the fine structures. The line shapes of the C 1s main lines are analyzed with respect to the different contributions of inhomogeneous broadening, vibronic coupling, and chemical shifts. The shake-up satellite spectra reveal trends, which give insight into the charge redistribution within the molecule upon photoexcitation. In particular, the shake-up between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) increases in intensity and moves closer toward the C 1s main line if the size of the aromatic system is increased. An explanation is given on the basis of the delocalization of the aromatic system and its capability in screening the photogenerated core hole. A comparison of the HOMO-LUMO shake-up position to the optical band gap gives additional insight into the reorganization of the electronic system upon photoexcitation.

Methylation-sensitive high-resolution melting-curve analysis of the SNRPN gene as a diagnostic screen for Prader-Willi and Angelman syndromes.

PubMed

White, Helen E; Hall, Victoria J; Cross, Nicholas C P

2007-11-01

Angelman syndrome (AS) and Prader-Willi syndrome (PWS) are 2 distinct neurodevelopmental disorders caused primarily by deficiency of specific parental contributions at an imprinted domain within the chromosomal region 15q11.2-13. Lack of paternal contribution results in PWS either by paternal deletion (approximately 70%) or maternal uniparental disomy (UPD) (approximately 25%). Most cases of AS result from the lack of a maternal contribution from this same region, by maternal deletion (70%) or paternal UPD (approximately 5%). Analysis of allelic methylation differences at the small nuclear ribonucleoprotein polypeptide N (SNRPN) locus differentiates the maternally and paternally inherited chromosome 15 and can be used as a diagnostic test for AS and PWS. Methylation-sensitive high-resolution melting-curve analysis (MS-HRM) using the DNA binding dye EvaGreen was used to analyze methylation differences at the SNRPN locus in anonymized DNA samples from individuals with PWS (n = 39) or AS (n = 31) and from healthy control individuals (n = 95). Results from the MS-HRM assay were compared to those obtained by use of a methylation-specific PCR (MSP) protocol that is used commonly in diagnostic practice. With the MS-HRM assay 97.6% of samples were unambiguously assigned to the 3 diagnostic categories (AS, PWS, normal) by use of automated calling with an 80% confidence percentage threshold, and the failure rate was 0.6%. One PWS sample showed a discordant result for the MS-HRM assay compared to MSP data. MS-HRM is a simple, rapid, and robust method for screening methylation differences at the SNRPN locus and could be used as a diagnostic screen for PWS and AS.

High-resolution Bent-crystal Spectrometer for the Ultra-soft X-ray Region

DOE R&D Accomplishments Database

Beiersdorfer, P.; von Goeler, S.; Bitter, M.; Hill, K. W.; Hulse, R. A.; Walling, R. S.

1988-10-01

A multichannel vacuum Brag-crystal spectrometer has been developed for high-resolution measurements of the line emission from tokamak plasmas in the wavelength region between 4 and 25 angstrom. The spectrometer employs a bent crystal in Johann geometry and a microchannel-plate intensified photodiode array. The instrument is capable of measuring high-resolution spectra (lambda/..delta..lambda approx. 3000) with fast time resolution (4 msec per spectrum) and good spatial resolution (3 cm). The spectral bandwidth is ..delta..lambda/lambda{sub 0} = 8 angstrom. A simple tilt mechanism allows access to different wavelength intervals. In order to illustrate the utility of the new spectrometer, time- and space-resolved measurements of the n = 3 to n = 2 spectrum of selenium from the Princeton Large Torus tokamak plasmas are presented. The data are used to determine the plasma transport parameters and to infer the radial distribution of fluorinelike, neonlike, and sodiumlike ions of selenium in the plasma. The new ultra-soft x-ray spectrometer has thus enabled us to demonstrate the utility of high-resolution L-shell spectroscopy of neonlike ions as a fusion diagnostic.

Super-Resolution Microscopy of Cerebrospinal Fluid Biomarkers as a Tool for Alzheimer's Disease Diagnostics.

PubMed

Zhang, William I; Antonios, Gregory; Rabano, Alberto; Bayer, Thomas A; Schneider, Anja; Rizzoli, Silvio O

2015-01-01

Alzheimer's disease (AD) is neuropathologically characterized by aggregates of amyloid-β peptides (Aβ) and tau proteins. The consensus in the AD field is that Aβ and tau should serve as diagnostic biomarkers for AD. However, their aggregates have been difficult to investigate by conventional fluorescence microscopy, since their size is below the diffraction limit (∼200 nm). To solve this, we turned to a super-resolution imaging technique, stimulated emission depletion (STED) microscopy, which has a high enough precision to allow the discrimination of low- and high-molecular weight aggregates prepared in vitro. We used STED to analyze the structural organization of Aβ and tau in cerebrospinal fluid (CSF) from 36 AD patients, 11 patients with mild cognitive impairment (MCI), and 21 controls. We measured the numbers of aggregates in the CSF samples, and the aggregate sizes and intensities. These parameters enabled us to distinguish AD patients from controls with a specificity of ∼87% and a sensitivity of ∼79% . In addition, the aggregate parameters determined with STED microscopy correlated with the severity of cognitive impairment in AD patients. Finally, these parameters may be useful as predictive tools for MCI cases. The STED parameters of two MCI patients who developed AD during the course of the study, as well as of MCI patients whose Aβ ELISA values fall within the accepted range for AD, placed them close to the AD averages. We suggest that super-resolution imaging is a promising tool for AD diagnostics.

Millimeter and Sub-millimeter High Resolution Spectroscopy: New Frontiers with ALMA

NASA Astrophysics Data System (ADS)

Ziurys, Lucy M.

2016-06-01

It is becoming increasingly clear that new laboratory data will be critical for the next decade of observations with the Atacama Large Millimeter Array (ALMA). The high spatial resolution offered by ALMA will probe new regions of molecular complexity, including the inner envelopes of evolved stars, regions dominated by UV radiation, and the densest cores of molecular clouds. New molecular lines will be discovered in the wide wavelength range covered by the ALMA bands, and high resolution, gas-phase spectroscopy are needed to provide crucial “rest frequencies.” In particular, highly accurate methods that measure millimeter and sub-millimeter rotational transitions, such as direct absorption and Fourier transform mm-wave techniques, are important, especially when coupled to exotic molecular production schemes. Recent ALMA studies of SH+ and larger organic species have already demonstrated the need for laboratory measurements. New laboratory work will likely be required for circumstellar refractory molecules, radicals and ions generated near photon-dominated regions (PDRs), and large, organic-type species. This talk will give an overview of current contributions of laboratory spectroscopy to ALMA observations, summarize relevant spectroscopic techniques, and provide input into future prospects and directions.

High-resolution NMR spectroscopy of encapsulated proteins dissolved in low-viscosity fluids

PubMed Central

Nucci, Nathaniel V.; Valentine, Kathleen G.; Wand, A. Joshua

2014-01-01

High-resolution multi-dimensional solution NMR is unique as a biophysical and biochemical tool in its ability to examine both the structure and dynamics of macromolecules at atomic resolution. Conventional solution NMR approaches, however, are largely limited to examinations of relatively small (< 25 kDa) molecules, mostly due to the spectroscopic consequences of slow rotational diffusion. Encapsulation of macromolecules within the protective nanoscale aqueous interior of reverse micelles dissolved in low viscosity fluids has been developed as a means through which the ‘slow tumbling problem’ can be overcome. This approach has been successfully applied to diverse proteins and nucleic acids ranging up to 100 kDa, considerably widening the range of biological macromolecules to which conventional solution NMR methodologies may be applied. Recent advances in methodology have significantly broadened the utility of this approach in structural biology and molecular biophysics. PMID:24656086

High resolution group refractive index measurement by broadband supercontinuum interferometry and wavelet-transform analysis

NASA Astrophysics Data System (ADS)

Reolon, David; Jacquot, Maxime; Verrier, Isabelle; Brun, Gérald; Veillas, Colette

2006-12-01

In this paper we propose group refractive index measurement with a spectral interferometric set-up using a broadband supercontinuum generated in an air-silica Microstructured Optical Fibre (MOF) pumped with a picosecond pulsed microchip laser. This source authorizes high fringes visibility for dispersion measurements by Spectroscopic Analysis of White Light Interferograms (SAWLI). Phase calculation is assumed by a wavelet transform procedure combined with a curve fit of the recorded channelled spectrum intensity. This approach provides high resolution and absolute group refractive index measurements along one line of the sample by recording a single 2D spectral interferogram without mechanical scanning.

The impact of high-resolution ultrasound in the differential diagnosis of non-hemolytic jaundice.

PubMed

Rauh, Peter; Neye, Holger; Mönkemüller, Klaus; Malfertheiner, Peter; Rickes, Steffen

2010-12-01

Because jaundice is a common reason for hospital admission. A fast and correct differential diagnosis is very important to increase treatment efficacy. The aim of our study was to evaluate the impact of the high-resolution ultrasound in this kind of clinical setting. In a prospective study we included 30 patients and we divided them in patients with extrahepatic jaundice and patients with intrahepatic jaundice. We observed a high accuracy of the high-resolution sonography, with a sensitivity of 95% and a specificity of 100% for extrahepatic jaundice, and a sensitivity of 100% and a specificity of 95% for intrahepatic jaundice. We conclude that the high-resolution ultrasound should be used in the very beginning of the diagnostic algorithm for the evaluation of patients with unclear jaundice.

A focal-spot diagnostic for on-shot characterization of high-energy petawatt lasers.

PubMed

Bromage, J; Bahk, S-W; Irwin, D; Kwiatkowski, J; Pruyne, A; Millecchia, M; Moore, M; Zuegel, J D

2008-10-13

An on-shot focal-spot diagnostic for characterizing high-energy, petawatt-class laser systems is presented. Accurate measurements at full energy are demonstrated using high-resolution wavefront sensing in combination with techniques to calibrate on-shot measurements with low-power sample beams. Results are shown for full-energy activation shots of the OMEGA EP Laser System.

Radial scanning diagnostics of bremsstrahlung and line emission in T-10 plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nemets, A. R., E-mail: Nemets-AR@nrcki.ru; Krupin, V. A.; Klyuchnikov, L. A., E-mail: lklyuchnikov@list.ru

2016-12-15

The paper describes the scanning spectroscopic diagnostics designed for measurement of line integrated plasma radiation in two visible spectral ranges. This diagnostic system is aimed at measuring the bremsstrahlung absolute values and profile with high spatial resolution. The bremsstrahlung absolute values are used to determine the value and radial distribution of effective plasma ion charge Z{sub eff}(r) in T-10 discharges. The importance of Z{sub eff} measurement is due to its strong influence on plasma heating, confinement, and stability. The spatial distribution of emission for one of the chosen spectral lines is measured simultaneously with bremsstrahlung. The spatial resolution of measurementsmore » is ~1 cm, and the temporal resolution is up to 10 ms. The spectral equipment and methods for its calibration are described. Examples of line integrated brightness distribution in a “continuum window” of 5236 ± 6 Å and brightness of the lines C{sup 5+} (5291 Å), He{sup 1+} (4686 Å), and D{sub β} (4861 Å) are given. Flattening of the bremsstrahlung brightness profile in the central region of the plasma column in some discharges with sawtooth oscillations in the T-10 is observed. The measured effective ion charge profiles in ohmic discharges with high plasma density and low discharge currents demonstrate accumulation of light impurities at the column axis; as a consequence, quenching of sawtooth oscillations in some discharges is observed. The developed diagnostics provides necessary data for investigation of heat, particle, and current transport in the plasma of the T-10. Successful application of the obtained data on Z{sub eff}(r) for investigation of geodesic acoustic modes of plasma oscillations in the T-10 should be specially noted.« less

Effect of Patient Navigation on Time to Diagnostic Resolution among Patients with Colorectal Cancer Related Abnormalities

PubMed Central

Lee, Ji-Hyun; Fulp, William; Wells, Kristen J.; Meade, Cathy D.; Calcano, Ercilia; Roetzheim, Richard

2013-01-01

Objectives The objective of this study is to evaluate whether a patient navigation (PN) program is effective in reducing delay in diagnostic resolution among medically underserved patients with colorectal cancer (CRC) related abnormalities in Tampa Bay, Florida. Methods This study involved 10 primary care clinics randomized either to receive navigation or serve as controls (5 clinics per arm). Each clinic identified all subjects with colorectal-related abnormalities in the year prior to the clinic beginning participation in the Moffitt Patient Navigation Research Program. Patients with CRC related abnormalities were navigated from time of a colorectal abnormality to diagnostic resolution. Control patients received usual care, and outcome information was obtained from medical record abstraction. Using a frailty Cox proportional hazard model, we examined the length of time between colorectal abnormality and definitive diagnosis. Results 193 patients were eligible for the study because of a colorectal cancer related abnormality (75 navigated; 118 control). Analysis of PN effect by two time periods of resolution (0-4 months and > 4 months) showed a lagged effect of PN. The adjusted time-varying PN effect on diagnostic resolution compared to control was marginally significant (adjusted Hazard Ratio, aHR=1.15, 95% CI: 1.02-1.29) after controlling for insurance status. The predicted aHR at 4 months was 1.2, but showed no significant effect until 12 months. Conclusions For patients having an abnormal symptom of CRC, PN appeared to have a positive effect over time and sped diagnostic resolution after 4 months. However, the small sample size limits drawing a definitive conclusion regarding the positive PN effect. PMID:24113902

Phased Array 3D MR Spectroscopic Imaging of the Brain at 7 Tesla

PubMed Central

Xu, Duan; Cunningham, Charles H; Chen, Albert P.; Li, Yan; Kelley, Douglas AC; Mukherjee, Pratik; Pauly, John M.; Nelson, Sarah J.; Vigneron, Daniel B.

2008-01-01

Ultrahigh field 7T MR scanners offer the potential for greatly improved MR spectroscopic imaging due to increased sensitivity and spectral resolution. Prior 7T human single-voxel MRS studies have shown significant increases in SNR and spectral resolution as compared to lower magnetic fields, but have not demonstrated the increase in spatial resolution and multivoxel coverage possible with 7T MR spectroscopic imaging. The goal of this study was to develop specialized rf pulses and sequences for 3D MRSI at 7T to address the challenges of increased chemical shift misregistration, B1 power limitations, and increased spectral bandwidth. The new 7T MRSI sequence was tested in volunteer studies and demonstrated the feasibility of obtaining high SNR phased-array 3D MRSI from the human brain. PMID:18486386

High-Resolution Infrared Spectroscopic Measurements of Comet 2PlEncke: Unusual Organic Composition and Low Rotational Temperatures

NASA Technical Reports Server (NTRS)

Radeva, Yana L.; Mumma, Michael J.; Villanueva, Geronimo L.; Bonev, Boncho P.; DiSanti, Michael A.; A'Hearn, Michael F.; Dello Russo, Neil

2013-01-01

We present high-resolution infrared spectroscopic measurements of the ecliptic comet 2P/Encke, observed on 4-6 Nov. 2003 during its close approach to the Earth, using the Near Infrared Echelle Spectrograph on the Keck II telescope. We present flux-calibrated spectra, production rates, and mixing ratios for H2O, CH3OH, HCN, H2CO, C2H2, C2H6, CH4 and CO. Comet 2P/Encke is a dynamical end-member among comets because of its short period of 3.3 years. Relative to "organics-normal" comets, we determined that 2PlEncke is depleted in HCN, H2CO, C2H2, C2H6, CH4 and CO, but it is enriched in CH3OH. We compared mixing ratios of these organic species measured on separate dates, and we see no evidence of macroscopic chemical heterogeneity in the nucleus of 2P/Encke, however, this conclusion is limited by sparse temporal sampling. The depleted abundances of most measured species suggest that 2P/Encke may have formed closer to the young Sun, before its insertion to the Kuiper belt, compared with "organics-normal" comets - as was previously suggested for other depleted comets (e.g. C/1999 S4 (LINEAR)). We measured very low rotational temperatures of 20 - 30 K for H2O, CH3OH and HCN in the near nucleus region of 2P/Encke, which correlate with one of the lowest cometary gas production rates (approx. 2.6 x 10(exp 27) molecules/s) measured thus far in the infrared. This suggests that we are seeing the effects of more efficient radiative cooling, insufficient collisional excitation, and/or inefficient heating by fast H-atoms (and icy grains) in the observed region of the coma. Its extremely short orbital period, very low gas production rate, and classification as an ecliptic comet, make 2PlEncke an important addition to our growing database, and contribute significantly to the establishment of a chemical taxonomy of comets.

Improved high-resolution ultrasonic imaging of the eye.

PubMed

Silverman, Ronald H; Ketterling, Jeffrey A; Mamou, Jonathan; Coleman, D Jackson

2008-01-01

Currently, virtually all clinical diagnostic ultrasound systems used in ophthalmology are based on fixed-focus, single-element transducers. High-frequency (> or = 20-MHz) transducers introduced to ophthalmology during the last decade have led to improved resolution and diagnostic capabilities for assessment of the anterior segment and the retina. However, single-element transducers are restricted to a small depth of field, limiting their capacity to image the eye as a whole. We fabricated a 20-MHz annular array probe prototype consisting of 5 concentric transducer elements and scanned an ex vivo human eye. Synthetically focused images of the bank eye showed improved depth of field and sensitivity, allowing simultaneous display of the anterior and posterior segments and the full lens contour. This capability may be useful in assessment of vitreoretinal pathologies and investigation of the accommodative mechanism.

SU-F-J-93: Automated Segmentation of High-Resolution 3D WholeBrain Spectroscopic MRI for Glioblastoma Treatment Planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schreibmann, E; Shu, H; Cordova, J

Purpose: We report on an automated segmentation algorithm for defining radiation therapy target volumes using spectroscopic MR images (sMRI) acquired at nominal voxel resolution of 100 microliters. Methods: Wholebrain sMRI combining 3D echo-planar spectroscopic imaging, generalized auto-calibrating partially-parallel acquisitions, and elliptical k-space encoding were conducted on 3T MRI scanner with 32-channel head coil array creating images. Metabolite maps generated include choline (Cho), creatine (Cr), and N-acetylaspartate (NAA), as well as Cho/NAA, Cho/Cr, and NAA/Cr ratio maps. Automated segmentation was achieved by concomitantly considering sMRI metabolite maps with standard contrast enhancing (CE) imaging in a pipeline that first uses the watermore » signal for skull stripping. Subsequently, an initial blob of tumor region is identified by searching for regions of FLAIR abnormalities that also display reduced NAA activity using a mean ratio correlation and morphological filters. These regions are used as starting point for a geodesic level-set refinement that adapts the initial blob to the fine details specific to each metabolite. Results: Accuracy of the segmentation model was tested on a cohort of 12 patients that had sMRI datasets acquired pre, mid and post-treatment, providing a broad range of enhancement patterns. Compared to classical imaging, where heterogeneity in the tumor appearance and shape across posed a greater challenge to the algorithm, sMRI’s regions of abnormal activity were easily detected in the sMRI metabolite maps when combining the detail available in the standard imaging with the local enhancement produced by the metabolites. Results can be imported in the treatment planning, leading in general increase in the target volumes (GTV60) when using sMRI+CE MRI compared to the standard CE MRI alone. Conclusion: Integration of automated segmentation of sMRI metabolite maps into planning is feasible and will likely streamline acceptance

Daniel K. Inouye Solar Telescope: High-resolution observing of the dynamic Sun

NASA Astrophysics Data System (ADS)

Tritschler, A.; Rimmele, T. R.; Berukoff, S.; Casini, R.; Kuhn, J. R.; Lin, H.; Rast, M. P.; McMullin, J. P.; Schmidt, W.; Wöger, F.; DKIST Team

2016-11-01

The 4-m aperture Daniel K. Inouye Solar Telescope (DKIST) formerly known as the Advanced Technology Solar Telescope (ATST) is currently under construction on Haleakalā (Maui, Hawai'i) projected to start operations in 2019. At the time of completion, DKIST will be the largest ground-based solar telescope providing unprecedented resolution and photon collecting power. The DKIST will be equipped with a set of first-light facility-class instruments offering unique imaging, spectroscopic and spectropolarimetric observing opportunities covering the visible to infrared wavelength range. This first-light instrumentation suite will include: a Visible Broadband Imager (VBI) for high-spatial and -temporal resolution imaging of the solar atmosphere; a Visible Spectro-Polarimeter (ViSP) for sensitive and accurate multi-line spectropolarimetry; a Fabry-Pérot based Visible Tunable Filter (VTF) for high-spatial resolution spectropolarimetry; a fiber-fed Diffraction-Limited Near Infra-Red Spectro-Polarimeter (DL-NIRSP) for two-dimensional high-spatial resolution spectropolarimetry (simultaneous spatial and spectral information); and a Cryogenic Near Infra-Red Spectro-Polarimeter (Cryo-NIRSP) for coronal magnetic field measurements and on-disk observations of, e.g., the CO lines at 4.7 μm. We will provide an overview of the DKIST's unique capabilities with strong focus on the first-light instrumentation suite, highlight some of the additional properties supporting observations of transient and dynamic solar phenomena, and touch on some operational strategies and the DKIST critical science plan.

High resolution spectroscopic measurements of carbon dioxide and carbon monoxide

NASA Technical Reports Server (NTRS)

Chaney, L. W.

1972-01-01

A modified 1.83 meter Jarrell-Ash spectrometer is reported. The instrument was double passed and achieved a resolution of 0.05 cm at 15 micrometers. An integrating voltmeter was used to optimize the available integration time. Data were obtained in the 15 micrometer and 4.3 micrometer band of CO2 and the 4.6 micrometer and 2.3 micrometer bands of CO. The data are summarized and examples of typical spectra are given. All the data are stored on IBM cards.

First results from the Goddard High-Resolution spectrograph - High-resolution observations of the 1942 A resonance line of HG II in the chemically peculiar B star, Chi Lupi

NASA Technical Reports Server (NTRS)

Leckrone, David S.; Wahlgren, Glenn M.; Johansson, Sveneric G.

1991-01-01

The Goddard High-Resolution Spectrograph on the HST has been used to obtain high S/N observations of the sharp-lined, Hg- and Pt-rich B-type star, Chi Lupi, with a resolving power of 87,000. The observations reveal a level of spectroscopic detail never before observed at ultraviolet wavelengths for any star other than the sun. Concentrating on the region around the resonance line of Hg II at 1942 A, the profile and central position of this line confirm beyond doubt that the Hg isotope anomaly in Chi Lupi is real and extreme, with Hg being heavily concentrated in the form of Hg-204. The problems in atomic physics which impair the accurate analysis of spectra of this quality are emphasized.

Utilization of high resolution computed tomography to visualize the three dimensional structure and function of plant vasculature

USDA-ARS?s Scientific Manuscript database

High resolution x-ray computed tomography (HRCT) is a non-destructive diagnostic imaging technique with sub-micron resolution capability that is now being used to evaluate the structure and function of plant xylem network in three dimensions (3D). HRCT imaging is based on the same principles as medi...

Optical coherence microscope for invariant high resolution in vivo skin imaging

NASA Astrophysics Data System (ADS)

Murali, S.; Lee, K. S.; Meemon, P.; Rolland, J. P.

2008-02-01

A non-invasive, reliable and affordable imaging system with the capability of detecting skin pathologies such as skin cancer would be a valuable tool to use for pre-screening and diagnostic applications. Optical Coherence Microscopy (OCM) is emerging as a building block for in vivo optical diagnosis, where high numerical aperture optics is introduced in the sample arm to achieve high lateral resolution. While high numerical aperture optics enables realizing high lateral resolution at the focus point, dynamic focusing is required to maintain the target lateral resolution throughout the depth of the sample being imaged. In this paper, we demonstrate the ability to dynamically focus in real-time with no moving parts to a depth of up to 2mm in skin-equivalent tissue in order to achieve 3.5μm lateral resolution throughout an 8 cubic millimeter sample. The built-in dynamic focusing ability is provided by an addressable liquid lens embedded in custom-designed optics which was designed for a broadband laser source of 120 nm bandwidth centered at around 800nm. The imaging probe was designed to be low-cost and portable. Design evaluation and tolerance analysis results show that the probe is robust to manufacturing errors and produces consistent high performance throughout the imaging volume.

High Resolution Far Infrared Fourier Transform Spectroscopy of the NH_2 Radical.

NASA Astrophysics Data System (ADS)

Martin-Drumel, M. A.; Pirali, O.; Balcon, D.; Vervloet, M.

2011-06-01

First identified toward Sgr B2, the NH_2 radical has recently been detected in the interstellar medium by the HIFI instrument on board of Herschel. Despite the fact that this radical has not been detected in brown dwarfs and exoplanets yet, it is already included in physical and chemical models of those environments (temperature higher than 2000 K expected in several objects). Its detection in those objects will depend on the existence of a reliable high temperature and high resolution spectroscopic database on the NH_2 radical.The absorption spectrum of NH_2 has been recorded between 15 and 700 Cm-1 at the highest resolution available using the Bruker IFS125HR Fourier transform interferometer connected to the far infrared AILES beamline at SOLEIL (R=0.001 Cm-1). The radical was produced by an electrical discharge (DC) through a continuous flow of NH_3 and He using the White-type discharge cell developped on the beamline (optical path: 24m). Thanks to the brilliance of the synchrotron radiation, more than 700 pure rotational transitions of NH_2 have been identified with high N values (NMax=25) in its fundamental and first excited vibrational modes. By comparison to the previous FT spectroscopic study on that radical in the FIR spectral range, asymmetric splitting as well as fine and hyperfine structure have been resolved for several transitions. E. F. Van Dishoeck, D. J. Jansen, P. Schilke, T. G. Phillips The Astrophysical Journal 416, L83-L86 (1993) C. M. Persson, J. H. Black, J. Cernicharo et al. Astronomy and Astrophysics 521, L45 (2010) K. Lodders and B. Fegley, Jr Icarus 155, 393-424 (2002) I. Morino and K. Kawaguchi Journal of Molecular Spectroscopy 182, 428-438 (1997)

High resolution time interval meter

DOEpatents

Martin, A.D.

1986-05-09

Method and apparatus are provided for measuring the time interval between two events to a higher resolution than reliability available from conventional circuits and component. An internal clock pulse is provided at a frequency compatible with conventional component operating frequencies for reliable operation. Lumped constant delay circuits are provided for generating outputs at delay intervals corresponding to the desired high resolution. An initiation START pulse is input to generate first high resolution data. A termination STOP pulse is input to generate second high resolution data. Internal counters count at the low frequency internal clock pulse rate between the START and STOP pulses. The first and second high resolution data are logically combined to directly provide high resolution data to one counter and correct the count in the low resolution counter to obtain a high resolution time interval measurement.

Guiding Biogeochemical Campaigns with High Resolution Altimetry: Waiting for the SWOT Mission

NASA Astrophysics Data System (ADS)

d'Ovidio, Francesco; Zhou, Meng; Park, Young Hyang; Nencioli, Francesco; Resplandy, Laure; Doglioli, Andrea; Petrenko, Anne; Blain, Stephane; Queguiner, Bernard

2013-09-01

Biogeochemical processes in the ocean are strongly affected by the horizontal mesoscale ( 10-100 km) and submesoscale (1-10 km) circulation. Eddies and filaments can create strong dishomogeneity, either amplifying small-scale diffusion processes (mixing) or creating tracer reservoirs. This variability has a direct effect on the biogeochemical budgets - controlling for instances tracer fluxes across climatological fronts, or part of the vertical exchanges. This variability also provides a challenge to in situ studies, because sites few tens of kms or few weeks apart may be representative of very different situations. Here we discuss how altimetry observation can be exploited in order to track in near- real-time transport barriers and mixing regions and guide a biogeochemical adaptative sampling strategy. As a case study, we focus on the recent KEOPS2 campaign (Kerguelen region, October-November 2012) which employed Lagrangian diagnostics of a specifically designed high resolution, regional altimetric product produced by CLS (with support from CNES) analyzed with several Lagrangian diagnostics. Such approach anticipates possible uses of incoming high resolution altimetry data for biogeochemical studies.

High Resolution Integrated Hohlraum-Capsule Simulations for Virtual NIF Ignition Campaign

NASA Astrophysics Data System (ADS)

Jones, O. S.; Marinak, M. M.; Cerjan, C. J.; Clark, D. S.; Edwards, M. J.; Haan, S. W.; Langer, S. H.; Salmonson, J. D.

2009-11-01

We have undertaken a virtual campaign to assess the viability of the sequence of NIF experiments planned for 2010 that will experimentally tune the shock timing, symmetry, and ablator thickness of a cryogenic ignition capsule prior to the first ignition attempt. The virtual campaign consists of two teams. The ``red team'' creates realistic simulated diagnostic data for a given experiment from the output of a detailed radiation hydrodynamics calculation that has physics models that have been altered in a way that is consistent with probable physics uncertainties. The ``blue team'' executes a series of virtual experiments and interprets the simulated diagnostic data from those virtual experiments. To support this effort we have developed a capability to do very high spatial resolution integrated hohlraum-capsule simulations using the Hydra code. Surface perturbations for all ablator layer surfaces and the DT ice layer are calculated explicitly through mode 30. The effects of the fill tube, cracks in the ice layer, and defects in the ablator are included in models extracted from higher resolution calculations. Very high wave number mix is included through a mix model. We will show results from these calculations in the context of the ongoing virtual campaign.

Development of a Multi-modal Tissue Diagnostic System Combining High Frequency Ultrasound and Photoacoustic Imaging with Lifetime Fluorescence Spectroscopy

PubMed Central

Sun, Yang; Stephens, Douglas N.; Park, Jesung; Sun, Yinghua; Marcu, Laura; Cannata, Jonathan M.; Shung, K. Kirk

2010-01-01

We report the development and validate a multi-modal tissue diagnostic technology, which combines three complementary techniques into one system including ultrasound backscatter microscopy (UBM), photoacoustic imaging (PAI), and time-resolved laser-induced fluorescence spectroscopy (TR-LIFS). UBM enables the reconstruction of the tissue microanatomy. PAI maps the optical absorption heterogeneity of the tissue associated with structure information and has the potential to provide functional imaging of the tissue. Examination of the UBM and PAI images allows for localization of regions of interest for TR-LIFS evaluation of the tissue composition. The hybrid probe consists of a single element ring transducer with concentric fiber optics for multi-modal data acquisition. Validation and characterization of the multi-modal system and ultrasonic, photoacoustic, and spectroscopic data coregistration were conducted in a physical phantom with properties of ultrasound scattering, optical absorption, and fluorescence. The UBM system with the 41 MHz ring transducer can reach the axial and lateral resolution of 30 and 65 μm, respectively. The PAI system with 532 nm excitation light from a Nd:YAG laser shows great contrast for the distribution of optical absorbers. The TR-LIFS system records the fluorescence decay with the time resolution of ~300 ps and a high sensitivity of nM concentration range. Biological phantom constructed with different types of tissues (tendon and fat) was used to demonstrate the complementary information provided by the three modalities. Fluorescence spectra and lifetimes were compared to differentiate chemical composition of tissues at the regions of interest determined by the coregistered high resolution UBM and PAI image. Current results demonstrate that the fusion of these techniques enables sequentially detection of functional, morphological, and compositional features of biological tissue, suggesting potential applications in diagnosis of tumors

Development of a Multi-modal Tissue Diagnostic System Combining High Frequency Ultrasound and Photoacoustic Imaging with Lifetime Fluorescence Spectroscopy.

PubMed

Sun, Yang; Stephens, Douglas N; Park, Jesung; Sun, Yinghua; Marcu, Laura; Cannata, Jonathan M; Shung, K Kirk

2008-01-01

We report the development and validate a multi-modal tissue diagnostic technology, which combines three complementary techniques into one system including ultrasound backscatter microscopy (UBM), photoacoustic imaging (PAI), and time-resolved laser-induced fluorescence spectroscopy (TR-LIFS). UBM enables the reconstruction of the tissue microanatomy. PAI maps the optical absorption heterogeneity of the tissue associated with structure information and has the potential to provide functional imaging of the tissue. Examination of the UBM and PAI images allows for localization of regions of interest for TR-LIFS evaluation of the tissue composition. The hybrid probe consists of a single element ring transducer with concentric fiber optics for multi-modal data acquisition. Validation and characterization of the multi-modal system and ultrasonic, photoacoustic, and spectroscopic data coregistration were conducted in a physical phantom with properties of ultrasound scattering, optical absorption, and fluorescence. The UBM system with the 41 MHz ring transducer can reach the axial and lateral resolution of 30 and 65 μm, respectively. The PAI system with 532 nm excitation light from a Nd:YAG laser shows great contrast for the distribution of optical absorbers. The TR-LIFS system records the fluorescence decay with the time resolution of ~300 ps and a high sensitivity of nM concentration range. Biological phantom constructed with different types of tissues (tendon and fat) was used to demonstrate the complementary information provided by the three modalities. Fluorescence spectra and lifetimes were compared to differentiate chemical composition of tissues at the regions of interest determined by the coregistered high resolution UBM and PAI image. Current results demonstrate that the fusion of these techniques enables sequentially detection of functional, morphological, and compositional features of biological tissue, suggesting potential applications in diagnosis of tumors

Electrochemical and spectroscopic study on the interaction between isoprenaline and DNA using multivariate curve resolution-alternating least squares.

PubMed

Ni, Yongnian; Wei, Min; Kokot, Serge

2011-11-01

Interaction of isoprenaline (ISO) with calf-thymus DNA was studied by spectroscopic and electrochemical methods. The behavior of ISO was investigated at a glassy carbon electrode (GCE) by cyclic voltammetry (CV) and differential pulse stripping voltammetry (DPSV); ISO was oxidized and an irreversible oxidation peak was observed. The binding constant K and the stoichiometric coefficient m of ISO with DNA were evaluated. Also, with the addition of DNA, hyperchromicity of the UV-vis absorption spectra of ISO was noted, while the fluorescence intensity decreased significantly. Multivariate curve resolution-alternating least squares (MCR-ALS) chemometrics method was applied to resolve the combined spectroscopic data matrix, which was obtained by the UV-vis and fluorescence methods. Pure spectra of ISO, DNA and ISO-DNA complex, and their concentration profiles were then successfully obtained. The results indicated that the ISO molecule intercalated into the base-pairs of DNA, and the complex of ISO-DNA was formed. Copyright © 2011 Elsevier B.V. All rights reserved.

Chemical Analysis of Exhaled Human Breath Using High Resolution Mm-Wave Rotational Spectra

NASA Astrophysics Data System (ADS)

Guo, Tianle; Branco, Daniela; Thomas, Jessica; Medvedev, Ivan; Dolson, David; Nam, Hyun-Joo; O, Kenneth

2014-06-01

High resolution rotational spectroscopy enables chemical sensors that are both sensitive and highly specific, which is well suited for analysis of expired human breath. We have previously reported on detection of breath ethanol, methanol, acetone, and acetaldehyde using THz sensors. This paper will outline our present efforts in this area, with specific focus on our ongoing quest to correlate levels of blood glucose with concentrations of a few breath chemicals known to be affected by elevated blood sugar levels. Prospects, challenges and future plans will be outlined and discussed. Fosnight, A.M., B.L. Moran, and I.R. Medvedev, Chemical analysis of exhaled human breath using a terahertz spectroscopic approach. Applied Physics Letters, 2013. 103(13): p. 133703-5.

High density plasmas and new diagnostics: An overview (invited).

PubMed

Celona, L; Gammino, S; Mascali, D

2016-02-01

One of the limiting factors for the full understanding of Electron Cyclotron Resonance Ion Sources (ECRISs) fundamental mechanisms consists of few types of diagnostic tools so far available for such compact machines. Microwave-to-plasma coupling optimisation, new methods of density overboost provided by plasma wave generation, and magnetostatic field tailoring for generating a proper electron energy distribution function, suitable for optimal ion beams formation, require diagnostic tools spanning across the entire electromagnetic spectrum from microwave interferometry to X-ray spectroscopy; these methods are going to be implemented including high resolution and spatially resolved X-ray spectroscopy made by quasi-optical methods (pin-hole cameras). The ion confinement optimisation also requires a complete control of cold electrons displacement, which can be performed by optical emission spectroscopy. Several diagnostic tools have been recently developed at INFN-LNS, including "volume-integrated" X-ray spectroscopy in low energy domain (2-30 keV, by using silicon drift detectors) or high energy regime (>30 keV, by using high purity germanium detectors). For the direct detection of the spatially resolved spectral distribution of X-rays produced by the electronic motion, a "pin-hole camera" has been developed also taking profit from previous experiences in the ECRIS field. The paper will give an overview of INFN-LNS strategy in terms of new microwave-to-plasma coupling schemes and advanced diagnostics supporting the design of new ion sources and for optimizing the performances of the existing ones, with the goal of a microwave-absorption oriented design of future machines.

High-resolution Spectroscopic Abundances of Red Giant Branch Stars in NGC 6681

DOE Office of Scientific and Technical Information (OSTI.GOV)

O’Malley, Erin M.; Chaboyer, Brian; Knaizev, Alexei

We obtain high-resolution spectra of nine red giant branch stars in NGC 6681 and perform the first detailed abundance analysis of stars in this cluster. We confirm cluster membership for these stars based on consistent radial velocities of 214.5 ± 3.7 km s{sup −1} and find a mean [Fe/H] = −1.63 ± 0.07 dex and [ α /Fe] = 0.42 ± 0.11 dex. Additionally, we confirm the existence of a Na–O anti-correlation in NGC 6681 and identify two populations of stars with unique abundance trends. With the use of HST photometry from Sarajedini et al. and Piotto et al. wemore » are able to identify these two populations as discrete sequences in the cluster CMD. Although we cannot confirm the nature of the polluter stars responsible for the abundance differences in these populations, these results do help put constraints on possible polluter candidates.« less

T.D.S. spectroscopic databank for spherical tops: DOS version

NASA Astrophysics Data System (ADS)

Tyuterev, V. G.; Babikov, Yu. L.; Tashkun, S. A.; Perevalov, V. I.; Nikitin, A.; Champion, J.-P.; Wenger, C.; Pierre, C.; Pierre, G.; Hilico, J.-C.; Loete, M.

1994-10-01

T.D.S. (Traitement de Donnees Spectroscopiques or Tomsk-Dijon-Spectroscopy project) is a computer package concerned with high resolution spectroscopy of spherical top molecules like CH4, CF4, SiH4, SiF4, SnH4, GeH4, SF6, etc. T.D.S. contains information, fundamental spectroscopic data (energies, transition moments, spectroscopic constants) recovered from comprehensive modeling and simultaneous fitting of experimental spectra, and associated software written in C. The T.D.S. goal is to provide an access to all available information on vibration-rotation molecular states and transitions including various spectroscopic processes (Stark, Raman, etc.) under extended conditions based on extrapolations of laboratory measurements using validated theoretical models. Applications for T.D.S. may include: education/training in molecular physics, quantum chemistry, laser physics; spectroscopic applications (analysis, laser spectroscopy, atmospheric optics, optical standards, spectroscopic atlases); applications to environment studies and atmospheric physics (remote sensing); data supply for specific databases; and to photochemistry (laser excitation, multiphoton processes). The reported DOS-version is designed for IBM and compatible personal computers.

Intratumoral Agreement of High-Resolution Magic Angle Spinning Magnetic Resonance Spectroscopic Profiles in the Metabolic Characterization of Breast Cancer

PubMed Central

Park, Vivian Youngjean; Yoon, Dahye; Koo, Ja Seung; Kim, Eun-Kyung; Kim, Seung Il; Choi, Ji Soo; Park, Seho; Park, Hyung Seok; Kim, Suhkmann; Kim, Min Jung

2016-01-01

Abstract High-resolution magic angle spinning (HR-MAS) magnetic resonance (MR) spectroscopy data may serve as a biomarker for breast cancer, with only a small volume of tissue sample required for assessment. However, previous studies utilized only a single tissue sample from each patient. The aim of this study was to investigate whether intratumoral location and biospecimen type affected the metabolic characterization of breast cancer assessed by HR-MAS MR spectroscopy This prospective study was approved by the institutional review board and informed consent was obtained. Preoperative core-needle biopsies (CNBs), central, and peripheral surgical tumor specimens were prospectively collected under ultrasound (US) guidance in 31 patients with invasive breast cancer. Specimens were assessed with HR-MAS MR spectroscopy. The reliability of metabolite concentrations was evaluated and multivariate analysis was performed according to intratumoral location and biospecimen type. There was a moderate or higher agreement between the relative concentrations of 94.3% (33 of 35) of metabolites in the center and periphery, 80.0% (28 of 35) of metabolites in the CNB and central surgical specimens, and 82.9% (29 of 35) of metabolites between all 3 specimen types. However, there was no significant agreement between the concentrations of phosphocholine (PC) and phosphoethanolamine (PE) in the center and periphery. The concentrations of several metabolites (adipate, arginine, fumarate, glutamate, PC, and PE) had no significant agreement between the CNB and central surgical specimens. In conclusion, most HR-MAS MR spectroscopic data do not differ based on intratumoral location or biospecimen type. However, some metabolites may be affected by specimen-related variables, and caution is recommended in decision-making based solely on metabolite concentrations, particularly PC and PE. Further validation through future studies is needed for the clinical implementation of these biomarkers based

Superresolution parallel magnetic resonance imaging: Application to functional and spectroscopic imaging

PubMed Central

Otazo, Ricardo; Lin, Fa-Hsuan; Wiggins, Graham; Jordan, Ramiro; Sodickson, Daniel; Posse, Stefan

2009-01-01

Standard parallel magnetic resonance imaging (MRI) techniques suffer from residual aliasing artifacts when the coil sensitivities vary within the image voxel. In this work, a parallel MRI approach known as Superresolution SENSE (SURE-SENSE) is presented in which acceleration is performed by acquiring only the central region of k-space instead of increasing the sampling distance over the complete k-space matrix and reconstruction is explicitly based on intra-voxel coil sensitivity variation. In SURE-SENSE, parallel MRI reconstruction is formulated as a superresolution imaging problem where a collection of low resolution images acquired with multiple receiver coils are combined into a single image with higher spatial resolution using coil sensitivities acquired with high spatial resolution. The effective acceleration of conventional gradient encoding is given by the gain in spatial resolution, which is dictated by the degree of variation of the different coil sensitivity profiles within the low resolution image voxel. Since SURE-SENSE is an ill-posed inverse problem, Tikhonov regularization is employed to control noise amplification. Unlike standard SENSE, for which acceleration is constrained to the phase-encoding dimension/s, SURE-SENSE allows acceleration along all encoding directions — for example, two-dimensional acceleration of a 2D echo-planar acquisition. SURE-SENSE is particularly suitable for low spatial resolution imaging modalities such as spectroscopic imaging and functional imaging with high temporal resolution. Application to echo-planar functional and spectroscopic imaging in human brain is presented using two-dimensional acceleration with a 32-channel receiver coil. PMID:19341804

Spectroscopic optical coherence tomography based on wavelength de-multiplexing and smart pixel array detection

NASA Astrophysics Data System (ADS)

Laubscher, Markus; Bourquin, Stéphane; Froehly, Luc; Karamata, Boris; Lasser, Theo

2004-07-01

Current spectroscopic optical coherence tomography (OCT) methods rely on a posteriori numerical calculation. We present an experimental alternative for accessing spectroscopic information in OCT without post-processing based on wavelength de-multiplexing and parallel detection using a diffraction grating and a smart pixel detector array. Both a conventional A-scan with high axial resolution and the spectrally resolved measurement are acquired simultaneously. A proof-of-principle demonstration is given on a dynamically changing absorbing sample. The method's potential for fast spectroscopic OCT imaging is discussed. The spectral measurements obtained with this approach are insensitive to scan non-linearities or sample movements.

High-Resolution Infrared and Electron-Diffraction Studies of Trimethylenecyclopropane ([3]-Radialene)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wright, Corey; Holmes, Joshua; Nibler, Joseph W.

2013-05-16

Combined high-resolution spectroscopic, electron-diffraction, and quantum theoretical methods are particularly advantageous for small molecules of high symmetry and can yield accurate structures that reveal subtle effects of electron delocalization on molecular bonds. The smallest of the radialene compounds, trimethylenecyclopropane, [3]-radialene, has been synthesized and examined in the gas phase by these methods. The first high-resolution infrared spectra have been obtained for this molecule of D3h symmetry, leading to an accurate B0 rotational constant value of 0.1378629(8) cm-1, within 0.5% of the value obtained from electronic structure calculations (density functional theory (DFT) B3LYP/cc-pVTZ). This result is employed in an analysis ofmore » electron-diffraction data to obtain the rz bond lengths (in Å): C-H = 1.072 (17), C-C = 1.437 (4), and C=C = 1.330 (4). The analysis does not lead to an accurate value of the HCH angle; however, from comparisons of theoretical and experimental angles for similar compounds, the theoretical prediction of 117.5° is believed to be reliable to within 2°. The effect of electron delocalization in radialene is to reduce the single C-C bond length by 0.07 Å compared to that in cyclopropane.« less

Silicon immersion gratings and their spectroscopic applications

NASA Astrophysics Data System (ADS)

Ge, Jian; Zhao, Bo; Powell, Scott; Fletcher, Adam; Wan, Xiaoke; Chang, Liang; Jakeman, Hali; Koukis, Dimitrios; Tanner, David B.; Ebbets, Dennis; Weinberg, Jonathan; Lipscy, Sarah; Nyquist, Rich; Bally, John

2012-09-01

Silicon immersion gratings (SIGs) offer several advantages over the commercial echelle gratings for high resolution infrared (IR) spectroscopy: 3.4 times the gain in dispersion or ~10 times the reduction in the instrument volume, a multiplex gain for a large continuous wavelength coverage and low cost. We present results from lab characterization of a large format SIG of astronomical observation quality. This SIG, with a 54.74 degree blaze angle (R1.4), 16.1 l/mm groove density, and 50x86 mm2 grating area, was developed for high resolution IR spectroscopy (R~70,000) in the near IR (1.1-2.5 μm). Its entrance surface was coated with a single layer of silicon nitride antireflection (AR) coating and its grating surface was coated with a thin layer of gold to increase its throughput at 1.1-2.5 μm. The lab measurements have shown that the SIG delivered a spectral resolution of R=114,000 at 1.55 μm with a lab testing spectrograph with a 20 mm diameter pupil. The measured peak grating efficiency is 72% at 1.55 μm, which is consistent with the measurements in the optical wavelengths from the grating surface at the air side. This SIG is being implemented in a new generation cryogenic IR spectrograph, called the Florida IR Silicon immersion grating spectrometer (FIRST), to offer broad-band high resolution IR spectroscopy with R=72,000 at 1.4-1.8 um under a typical seeing condition in a single exposure with a 2kx2k H2RG IR array at the robotically controlled Tennessee State University 2-meter Automatic Spectroscopic Telescope (AST) at Fairborn Observatory in Arizona. FIRST is designed to provide high precision Doppler measurements (~4 m/s) for the identification and characterization of extrasolar planets, especially rocky planets in habitable zones, orbiting low mass M dwarf stars. It will also be used for other high resolution IR spectroscopic observations of such as young stars, brown dwarfs, magnetic fields, star formation and interstellar mediums. An optimally designed

High-Resolution Anorectal Manometry - New Insights in the Diagnostic Assessment of Functional Anorectal Disorders.

PubMed

Heinrich, Henriette; Misselwitz, Benjamin

2018-04-01

Functional anorectal disorders such as faecal incontinence (FI), functional anorectal pain, and functional defecation disorders (FDD) are highly prevalent and represent a high socioeconomic burden. Several tests of anorectal function exist in this setting; however, high-resolution anorectal manometry (HR-ARM) is a new tool that depicts pressure all along the anal canal and can assess rectoanal coordination. HR-ARM is used in the diagnosis of FI and especially FDD although data in health is still sparse, and pressure phenomena seen during simulated defecation, such as dyssynergia, are highly prevalent in health.

Digital Fresnel reflection holography for high-resolution 3D near-wall flow measurement.

PubMed

Kumar, S Santosh; Hong, Jiarong

2018-05-14

We propose a novel backscatter holographic imaging system, as a compact and effective tool for 3D near-wall flow diagnostics at high resolutions, utilizing light reflected at the solid-liquid interface as a reference beam. The technique is fully calibrated, and is demonstrated in a densely seeded channel to achieve a spatial resolution of near-wall flows equivalent to or exceeding prior digital inline holographic measurements using local tracer seeding technique. Additionally, we examined the effects of seeding concentration and laser coherence on the measurement resolution and sample volume resolved, demonstrating the potential to manipulate sample domain by tuning the laser coherence profile.

The IACOB project. V. Spectroscopic parameters of the O-type stars in the modern grid of standards for spectral classification

NASA Astrophysics Data System (ADS)

Holgado, G.; Simón-Díaz, S.; Barbá, R. H.; Puls, J.; Herrero, A.; Castro, N.; Garcia, M.; Maíz Apellániz, J.; Negueruela, I.; Sabín-Sanjulián, C.

2018-06-01

Context. The IACOB and OWN surveys are two ambitious, complementary observational projects which have made available a large multi-epoch spectroscopic database of optical high resolution spectra of Galactic massive O-type stars. Aims: Our aim is to study the full sample of (more than 350) O stars surveyed by the IACOB and OWN projects. As a first step towards this aim, we have performed the quantitative spectroscopic analysis of a subsample of 128 stars included in the modern grid of O-type standards for spectral classification. The sample comprises stars with spectral types in the range O3-O9.7 and covers all luminosity classes. Methods: We used the semi-automatized IACOB-BROAD and IACOB-GBAT/FASTWIND tools to determine the complete set of spectroscopic parameters that can be obtained from the optical spectrum of O-type stars. A quality flag was assigned to the outcome of the IACOB-GBAT/FASTWIND analysis for each star, based on a visual evaluation of how the synthetic spectrum of the best fitting FASTWIND model reproduces the observed spectrum. We also benefitted from the multi-epoch character of the IACOB and OWN surveys to perform a spectroscopic variability study of the complete sample, providing two different flags for each star accounting for spectroscopic binarity as well as variability of the main wind diagnostic lines. Results: We obtain - for the first time in a homogeneous and complete manner - the full set of spectroscopic parameters of the "anchors" of the spectral classification system in the O star domain. We provide a general overview of the stellar and wind parameters of this reference sample, as well as updated recipes for the SpT-Teff and SpT-log g calibrations for Galactic O-type stars. We also propose a distance-independent test for the wind-momentum luminosity relationship. We evaluate the reliability of our semi-automatized analysis strategy using a subsample of 40 stars extensively studied in the literature, and find a fairly good agreement

Confocal Raman spectroscopic analysis of cross-linked ultra-high molecular weight polyethylene for application in artificial hip joints.

PubMed

Pezzotti, Giuseppe; Kumakura, Tsuyoshi; Yamada, Kiyotaka; Tateiwa, Toshiyuki; Puppulin, Leonardo; Zhu, Wenliang; Yamamoto, Kengo

2007-01-01

Confocal spectroscopic techniques are applied to selected Raman bands to study the microscopic features of acetabular cups made of ultra-high molecular weight polyethylene (UHMWPE) before and after implantation in vivo. The micrometric lateral resolution of a laser beam focused on the polymeric surface (or subsurface) enables a highly resolved visualization of 2-D conformational population patterns, including crystalline, amorphous, orthorhombic phase fractions, and oxidation index. An optimized confocal probe configuration, aided by a computational deconvolution of the optical probe, allows minimization of the probe size along the in-depth direction and a nondestructive evaluation of microstructural properties along the material subsurface. Computational deconvolution is also attempted, based on an experimental assessment of the probe response function of the polyethylene Raman spectrum, according to a defocusing technique. A statistical set of high-resolution microstructural data are collected on a fully 3-D level on gamma-ray irradiated UHMWPE acetabular cups both as-received from the maker and after retrieval from a human body. Microstructural properties reveal significant gradients along the immediate material subsurface and distinct differences are found due to the loading history in vivo, which cannot be revealed by conventional optical spectroscopy. The applicability of the confocal spectroscopic technique is valid beyond the particular retrieval cases examined in this study, and can be easily extended to evaluate in-vitro tested components or to quality control of new polyethylene brands. Confocal Raman spectroscopy may also contribute to rationalize the complex effects of gamma-ray irradiation on the surface of medical grade UHMWPE for total joint replacement and, ultimately, to predict their actual lifetime in vivo.

[High-contrast resolution of film-screen systems in oral and maxillofacial radiology].

PubMed

Kaeppler, G; Reinert, S

2007-11-01

The aim was to determine differences in high-contrast resolution of film-screen systems used in dental panoramic and cephalometric radiography by calculating the modulation transfer function (MTF). The radiographs used to determine the MTF should be taken by the same x-ray units as those used for patient radiographs. The MTF was determined using a lead grid and according to DIN 6867-2 for 11 film-screen systems (speed 250, speed class 200 and 400) used in dental radiographic diagnostics. The optical density was measured using a microdensitometer developed by PTB. With 10% of the modulation transfer factor, newly developed film-screen systems (speed class 200 and 400) demonstrated a resolution of 4.9 to 6 line pairs per mm (panoramic radiography). In cephalometric radiography a film-screen system (speed class 400 and green-sensitive film) had a resolution of 4.2 line pairs per mm and surpassed two film-screen systems (speed class 400, resolution of 3 line pairs per mm, blue-sensitive films). The relevance of this study is underlined by the diagnostic reference doses defined in the German X-ray Ordinance (RöV) which are also intended for dentistry. Film-screen systems (speed 250, speed class 200) previously used in dental panoramic and cephalometric radiography can be replaced by newly developed film-screen systems (speed class 400). In dental radiography dose reductions are possible with film-screen systems (speed class 400) without impairing diagnostic accuracy. The introduction of newly developed film-screen systems (speed class 400) requires lower milliampere-seconds and therefore an adjustment of the x-ray units to lower milliampere settings.

New high-precision orbital and physical parameters of the double-lined low-mass spectroscopic binary BY Draconis

NASA Astrophysics Data System (ADS)

Hełminiak, K. G.; Konacki, M.; Muterspaugh, M. W.; Browne, S. E.; Howard, A. W.; Kulkarni, S. R.

2012-01-01

We present the most precise to date orbital and physical parameters of the well-known short period (P= 5.975 d), eccentric (e= 0.3) double-lined spectroscopic binary BY Draconis (BY Dra), a prototype of a class of late-type, active, spotted flare stars. We calculate the full spectroscopic/astrometric orbital solution by combining our precise radial velocities (RVs) and the archival astrometric measurements from the Palomar Testbed Interferometer (PTI). The RVs were derived based on the high-resolution echelle spectra taken between 2004 and 2008 with the Keck I/high-resolution echelle spectrograph, Shane/CAT/HamSpec and TNG/SARG telescopes/spectrographs using our novel iodine-cell technique for double-lined binary stars. The RVs and available PTI astrometric data spanning over eight years allow us to reach 0.2-0.5 per cent level of precision in Msin 3i and the parallax but the geometry of the orbit (i≃ 154°) hampers the absolute mass precision to 3.3 per cent, which is still an order of magnitude better than for previous studies. We compare our results with a set of Yonsei-Yale theoretical stellar isochrones and conclude that BY Dra is probably a main-sequence system more metal rich than the Sun. Using the orbital inclination and the available rotational velocities of the components, we also conclude that the rotational axes of the components are likely misaligned with the orbital angular momentum. Given BY Dra's main-sequence status, late spectral type and the relatively short orbital period, its high orbital eccentricity and probable spin-orbit misalignment are not in agreement with the tidal theory. This disagreement may possibly be explained by smaller rotational velocities of the components and the presence of a substellar mass companion to BY Dra AB.

PUCHEROS: a cost-effective solution for high-resolution spectroscopy with small telescopes

NASA Astrophysics Data System (ADS)

Vanzi, L.; Chacon, J.; Helminiak, K. G.; Baffico, M.; Rivinius, T.; Štefl, S.; Baade, D.; Avila, G.; Guirao, C.

2012-08-01

We present PUCHEROS, the high-resolution echelle spectrograph, developed at the Center of Astro-Engineering of Pontificia Universidad Catolica de Chile to provide an effective tool for research and teaching of astronomy. The instrument is fed by a single-channel optical fibre and it covers the visible range from 390 to 730 nm in one shot, reaching a spectral resolution of about 20 000. In the era of extremely large telescopes our instrument aims to exploit the capabilities offered by small telescopes in a cost-effective way, covering the observing needs of a community of astronomers, in Chile and elsewhere, which do not necessarily need large collecting areas for their research. In particular the instrument is well suited for long-term spectroscopic monitoring of bright variable and transient targets down to a V magnitude of about 10. We describe the instrument and present a number of text case examples of observations obtained during commissioning and early science.

Study of high resolution x-ray spectrometer concepts for NIF experiments

NASA Astrophysics Data System (ADS)

Hill, K. W.; Bitter, M.; Delgado-Aparicio, L.; Efthimion, P.; Gao, L.; Maddox, J.; Pablant, N. A.; Beiersdorfer, P.; Chen, H.; Coppari, F.; Ma, T.; Nora, R.; Scott, H.; Schneider, M.; Mancini, R.

2015-11-01

Options have been investigated for DIM-insertable (Diagnostic Instrument Manipulator) high resolution (E/ ΔE ~ 3000 - 5000) Bragg crystal x-ray spectrometers for experiments on the NIF. Of interest are time integrated Cu K- and Ta L-edge absorption spectra and time resolved Kr He- β emission from compressed symcaps for inference of electron temperature from dielectronic satellites and electron density from Stark broadening. Cylindrical and conical von Hamos, Johann, and advanced high throughput designs have been studied. Predicted x-ray intensities, spectrometer throughputs, spectral resolution, and spatial focusing properties, as well as lab evaluations of some spectrometer candidates will be presented. Performed under the auspices of the US DOE by PPPL under contract DE-AC02-09CH11466 and by LLNL under contract DE-AC52-07NA27344.

Stratospheric HNO3 measurements from 0.002/cm resolution solar occultation spectra and improved spectroscopic line parameters in the 5.8-micron region

NASA Technical Reports Server (NTRS)

Goldman, A.; Murcray, F. J.; Blatherwick, R. D.; Kosters, J. J.; Murcray, D. G.; Rinsland, C. P.; Flaud, J.-M.; Camy-Peyret, C.

1992-01-01

Very-high-resolution FWHM solar-occultation spectra are investigated with a balloon-borne interferometer using revised spectroscopic line parameters for HNO3, O3, and H2O. The O3 and H2O data are evaluated to determine their capacity for interference in the HNO3 line which is studied in the nu sub 2 band at 5.8 microns. The line parameters developed with the stratospheric data are compared to data based on a HITRAN compilation as well as laboratory spectra with a 0.002/cm resolution. The line list is calculated and shown to include J and Ka transitions which improve the line parameters for HNO3 by accounting for the weaker absorption features in the stratospheric spectra. The stratospheric HNO3 profile developed analytically is compared to those based on reported measurements, and the one developed with the stratospheric solar spectra is found to be consistent with the measurements and confirm inherent measurement biases.

Spectroscopic diagnostics of extended corona and solar wind with UVCS/Spartan

NASA Technical Reports Server (NTRS)

Strachan, L.; Gardner, L. D.; Kohl, J. L.

1995-01-01

The primary goal of the Ultraviolet Coronal Spectrometer on Spartan 201 (UVCS/Spartan) is to make spectroscopic diagnostic measurements that can be used to derive plasma parameters in the extended solar corona where it is believed that significant heating of the corona and acceleration of the solar wind take place. Direct and indirect measurements of particle velocity distribution, thermal and non-thermal temperatures, and bulk outflow velocities are crucial to aid in the identification of physical processes that may be responsible for coronal heating and solar wind acceleration. UVCS/Spartan has made two flights in April 1993 and September 1994, the latter coinciding with the South Polar Passage of the Ulysses spacecraft. Observations were made of the large-scale structures and sub-structures of coronal holes and streamers at heliocentric heights between 1.5 solar radii and 3.5 solar radii. Measurements were made of H I Lyman-alpha intensities and profiles, and line intensities of minor ions like O(5+) and Fe(11+). We will present results from the flights and discuss how these measurements are used to constrain values for the proton thermal and non-thermal kinetic temperatures, proton bulk outflow velocities, and minor ion temperatures and bulk outflow velocities. Plans for the upcoming flight in July 1995 will also be discussed.

MARVEL analysis of the measured high-resolution spectra of 14NH3

NASA Astrophysics Data System (ADS)

Al Derzi, Afaf R.; Furtenbacher, Tibor; Tennyson, Jonathan; Yurchenko, Sergei N.; Császár, Attila G.

2015-08-01

Accurate, experimental rotational-vibrational energy levels and line positions, with associated labels and uncertainties, are reported for the ground electronic state of the symmetric-top 14NH3 molecule. All levels and lines are based on critically reviewed and validated high-resolution experimental spectra taken from 56 literature sources. The transition data are in the 0.7-17 000 cm-1 region, with a large gap between 7000 and 15 000 cm-1. The MARVEL (Measured Active Rotational-Vibrational Energy Levels) algorithm is used to determine the energy levels. Out of the 29 450 measured transitions 10 041 and 18 947 belong to ortho- and para-14NH3, respectively. A careful analysis of the related experimental spectroscopic network (SN) allows 28 530 of the measured transitions to be validated, 18 178 of these are unique, while 462 transitions belong to floating components. Despite the large number of spectroscopic measurements published over the last 80 years, the transitions determine only 30 vibrational band origins of 14NH3, 8 for ortho- and 22 for para-14NH3. The highest J value, where J stands for the rotational quantum number, for which an energy level is validated is 31. The number of experimental-quality ortho- and para-14NH3 rovibrational energy levels is 1724 and 3237, respectively. The MARVEL energy levels are checked against ones in the BYTe first-principles database, determined previously. The lists of validated lines and levels for 14NH3 are deposited in the Supporting Information to this paper. Combination of the MARVEL energy levels with first-principles absorption intensities yields a huge number of experimental-quality rovibrational lines, which should prove to be useful for the understanding of future complex high-resolution spectroscopy on 14NH3; these lines are also deposited in the Supporting Information to this paper.

Patient navigation improves cancer diagnostic resolution: an individually randomized clinical trial in an underserved population.

PubMed

Raich, Peter C; Whitley, Elizabeth M; Thorland, William; Valverde, Patricia; Fairclough, Diane

2012-10-01

Barriers to timely resolution of abnormal cancer screening tests add to cancer health disparities among low-income, uninsured, and minority populations. We conducted a randomized trial to evaluate the impact of lay patient navigators on time to resolution and completion of follow-up testing among patients with abnormal screening tests in a medically underserved patient population. Denver Health, the safety-net health care system serving Denver, is one of 10 performance sites participating in the Patient Navigation Research Program. Of 993 eligible subjects with abnormal screening tests randomized to navigation and no-navigation (control) arms and analyzed, 628 had abnormal breast screens (66 abnormal clinical breast examinations, 304 BIRADS 0, 200 BIRADS 3, 58 BIRADS 4 or 5) whereas 235 had abnormal colorectal and 130 had abnormal prostate screens. Time to resolution was significantly shorter in the navigated group (stratified log rank test, P < 0.001). Patient navigation improved diagnostic resolution for patients presenting with mammographic BIRADS 3 (P = 0.0003) and BIRADS 0 (P = 0.09), but not BIRADS 4/5 or abnormal breast examinations. Navigation shortened the time for both colorectal (P = 0.0017) and prostate screening resolution (P = 0.06). Participant demographics included 72% minority, 49% with annual household income less than $10,000, and 36% uninsured. Patient navigation positively impacts time to resolution of abnormal screening tests for breast, colorectal, and prostate cancers in a medically underserved population. By shortening the time to and increasing the proportion of patients with diagnostic resolution patient navigation could reduce disparities in stage at diagnosis and improve cancer outcomes. 2012 AACR

Linear Response Equilibrium versus echo-planar encoding for fast high-spatial resolution 3D chemical shift imaging

NASA Astrophysics Data System (ADS)

Fischer, Rudolf Fritz; Baltes, Christof; Weiss, Kilian; Pazhenkottil, Aju; Rudin, Markus; Boesiger, Peter; Kozerke, Sebastian

2011-07-01

In this work Linear Response Equilibrium (LRE) and Echo-planar spectroscopic imaging (EPSI) are compared in terms of sensitivity per unit time and power deposition. In addition an extended dual repetition time scheme to generate broad stopbands for improved inherent water suppression in LRE is presented. The feasibility of LRE and EPSI for assessing cholesterol esters in human carotid plaques with high spatial resolution of 1.95 × 1.15 × 1.15 mm 3 on a clinical 3T MR system is demonstrated. In simulations and phantom experiments it is shown that LRE has comparable but lower sensitivity per unit time relative to EPSI despite stronger signal generated. This relates to the lower sampling efficiency in LRE relative to EPSI as a result of limited gradient performance on clinical MR systems. At the same time, power deposition of LRE is significantly reduced compared to EPSI making it an interesting niche application for in vivo high field spectroscopic imaging of metabolites within a limited bandwidth.

Submillimeter Spectroscopic Study of Semiconductor Processing Plasmas

NASA Astrophysics Data System (ADS)

Helal, Yaser H.

Plasmas used for manufacturing processes of semiconductor devices are complex and challenging to characterize. The development and improvement of plasma processes and models rely on feedback from experimental measurements. Current diagnostic methods are not capable of measuring absolute densities of plasma species with high resolution without altering the plasma, or without input from other measurements. At pressures below 100 mTorr, spectroscopic measurements of rotational transitions in the submillimeter/terahertz (SMM) spectral region are narrow enough in relation to the sparsity of spectral lines that absolute specificity of measurement is possible. The frequency resolution of SMM sources is such that spectral absorption features can be fully resolved. Processing plasmas are a similar pressure and temperature to the environment used to study astrophysical species in the SMM spectral region. Many of the molecular neutrals, radicals, and ions present in processing plasmas have been studied in the laboratory and their absorption spectra have been cataloged or are in the literature for the purpose of astrophysical study. Recent developments in SMM devices have made its technology commercially available for applications outside of specialized laboratories. The methods developed over several decades in the SMM spectral region for these laboratory studies are directly applicable for diagnostic measurements in the semiconductor manufacturing industry. In this work, a continuous wave, intensity calibrated SMM absorption spectrometer was developed as a remote sensor of gas and plasma species. A major advantage of intensity calibrated rotational absorption spectroscopy is its ability to determine absolute concentrations and temperatures of plasma species from first principles without altering the plasma environment. An important part of this work was the design of the optical components which couple 500 - 750 GHz radiation through a commercial inductively coupled plasma

X-ray Spectroscopy of High-Z Elements on Nike

NASA Astrophysics Data System (ADS)

Aglitskiy, Y.; Weaver, J. L.; Karasik, M.; Serlin, V.; Obenschain, S. P.; Ralchenko, Yu.

2013-10-01

Survey X-ray spectrometer covering a spectral range from 0.5 to 19.5 angstroms has been added to the spectroscopic suite of Nike diagnostics. That allows simultaneous observation of both M- and N- spectra of W, Ta and Au with high spectral resolution. Low energy test shots confirmed strong presence of 3-4 transitions of Ni-like W, Ta and Au with X-ray energies as high as 3.5 keV when above mentioned elements were used as the targets. In our continuous effort to support DOE-NNSA's inertial fusion program, the future campaign will cover a wide range of plasma conditions that result in relatively energetic X-ray production. Eventually, absolutely calibrated spectrometers of similar geometry will be fielded at NIF in cooperation with NIF diagnostic group. Work supported by US DOE, Defense Programs.

Electromagnetic diagnostics of ECR-Ion Sources plasmas: optical/X-ray imaging and spectroscopy

NASA Astrophysics Data System (ADS)

Mascali, D.; Castro, G.; Altana, C.; Caliri, C.; Mazzaglia, M.; Romano, F. P.; Leone, F.; Musumarra, A.; Naselli, E.; Reitano, R.; Torrisi, G.; Celona, L.; Cosentino, L. G.; Giarrusso, M.; Gammino, S.

2017-12-01

Magnetoplasmas in ECR-Ion Sources are excited from gaseous elements or vapours by microwaves in the range 2.45-28 GHz via Electron Cyclotron Resonance. A B-minimum, magnetohydrodynamic stable configuration is used for trapping the plasma. The values of plasma density, temperature and confinement times are typically ne= 1011-1013 cm-3, 01 eVdiagnostics tools have been developed for probing the electromagnetic emission of such plasmas, in the optical/X-ray domain. Fast Silicon Drift detectors with high energy resolution of 125 eV at 5.9 keV have been used for the characterization of plasma emission at 02resolution down to 30 μm and an energy resolution down to 140 eV at 5.9 keV . In parallel, imaging in the optical range and spectroscopic measurements have been carried out. Relative abundances of H/H2 atoms/molecules in the plasmas have been measured for different values of neutral pressure, microwave power and magnetic field profile (they are critical for high-power proton sources).

CARMENES science preparation. High-resolution spectroscopy of M dwarfs

NASA Astrophysics Data System (ADS)

Montes, D.; Caballero, J. A.; Jeffers, S.; Alonso-Floriano, F. J.; Mundt, R.; CARMENES Consortium

2015-05-01

To ensure an efficient use of CARMENES observing time, and the highest chances of success, it is necessary first to select the most promising targets. To achieve this, we are observing 500 M dwarfs at high-resolution (R = 30,000-48,000), from which we determine the projected rotational velocity vsin{i} with an accuracy better than 0.5-0.2 km/s and radial-velocity stability better than 0.2-0.1 km/s. Our aim is to have at least two spectra at different epochs of the final 300 CARMENES targets. Our observations with FEROS at ESO/MPG 2.2 m La Silla, CAFE at 2.2 m Calar Alto and HRS at Hobby Eberly Telescope allow us to identify single- and double-line spectroscopic binaries and, especially, fast rotators, which should be discarded from the target list for exoplanet searches. Here we present preliminary results.

High-resolution electronic spectra of yttrium oxide (YO): The D2Σ+-X2Σ+ transition.

PubMed

Zhang, Deping; Zhang, Qiang; Zhu, Boxing; Gu, Jingwang; Suo, Bingbing; Chen, Yang; Zhao, Dongfeng

2017-03-21

The D 2 Σ + -X 2 Σ + electronic absorption spectrum of the astrophysically relevant yttrium oxide (YO) molecule has been recorded for the first time in the 400-440 nm region using laser induced fluorescence. YO molecules are produced by corona discharge of oxygen between the tips of two yttrium needles in a supersonic jet expansion. An unambiguous spectroscopic identification of the D 2 Σ + -X 2 Σ + transition becomes possible from a combined analysis of the moderate-resolution laser excitation spectrum and dispersed fluorescence spectrum. We have also performed multi-state complete active space second order perturbation theory calculations on the first six doublets of YO, and the results support our assignment of the D 2 Σ + state. Accurate spectroscopic constants for D 2 Σ + ν' = 0 and 1 levels have been determined from a rotational analysis of the high resolution spectra that are recorded with a resolution of ∼0.018 cm -1 . Severe perturbations are observed in the experimental spectra and are considered to originate from interactions with at least one nearby 2/4 Π electronic state, e.g., the undetected C 2 Π state. We have also measured the radiative lifetimes of B 2 Σ + ν' = 0, and D 2 Σ + ν' = 0 and 1 states, based on which the B 2 Σ + -X 2 Σ + (0, 0) and D 2 Σ + -X 2 Σ + (0/1, 0) band oscillator strengths have been determined.

High-resolution electronic spectra of yttrium oxide (YO): The D2Σ+-X2Σ+ transition

NASA Astrophysics Data System (ADS)

Zhang, Deping; Zhang, Qiang; Zhu, Boxing; Gu, Jingwang; Suo, Bingbing; Chen, Yang; Zhao, Dongfeng

2017-03-01

The D2Σ+ -X2Σ+ electronic absorption spectrum of the astrophysically relevant yttrium oxide (YO) molecule has been recorded for the first time in the 400-440 nm region using laser induced fluorescence. YO molecules are produced by corona discharge of oxygen between the tips of two yttrium needles in a supersonic jet expansion. An unambiguous spectroscopic identification of the D2Σ+ -X2Σ+ transition becomes possible from a combined analysis of the moderate-resolution laser excitation spectrum and dispersed fluorescence spectrum. We have also performed multi-state complete active space second order perturbation theory calculations on the first six doublets of YO, and the results support our assignment of the D2Σ+ state. Accurate spectroscopic constants for D2Σ+ ν ' = 0 and 1 levels have been determined from a rotational analysis of the high resolution spectra that are recorded with a resolution of ˜0.018 cm-1. Severe perturbations are observed in the experimental spectra and are considered to originate from interactions with at least one nearby 2/4Π electronic state, e.g., the undetected C2Π state. We have also measured the radiative lifetimes of B2 Σ+ ν ' = 0, and D2 Σ+ ν ' = 0 and 1 states, based on which the B2Σ+ -X2Σ+ (0, 0) and D2Σ+ -X2Σ+ (0/1, 0) band oscillator strengths have been determined.

Lineshape spectroscopy with a very high resolution, very high signal-to-noise crystal spectrometer

DOE PAGES

Beiersdorfer, P.; Magee, E. W.; Brown, G. V.; ...

2016-06-06

Here, we have developed a high-resolution x-ray spectrometer for measuring the shapes of spectral lines produced from laser-irradiated targets on the Orion laser facility. The instrument utilizes a spherically bent crystal geometry to spatially focus and spectrally analyze photons from foil or microdot targets. The high photon collection efficiency resulting from its imaging properties allows the instrument to be mounted outside the Orion chamber, where it is far less sensitive to particles, hard x-rays, or electromagnetic pulses than instruments housed close to the target chamber center in ten-inch manipulators. Moreover, Bragg angles above 50° are possible, which provide greatly improvedmore » spectral resolution compared to radially viewing, near grazing-incidence crystal spectrometers. These properties make the new instrument an ideal lineshape diagnostic for determining plasma temperature and density. We describe its calibration on the Livermore electron beam ion trap facility and present spectral data of the K-shell emission from highly charged sulfur produced by long-pulse as well as short-pulse beams on the Orion laser in the United Kingdom.« less

Lineshape spectroscopy with a very high resolution, very high signal-to-noise crystal spectrometer

NASA Astrophysics Data System (ADS)

Beiersdorfer, P.; Magee, E. W.; Brown, G. V.; Chen, H.; Emig, J.; Hell, N.; Bitter, M.; Hill, K. W.; Allan, P.; Brown, C. R. D.; Hill, M. P.; Hoarty, D. J.; Hobbs, L. M. R.; James, S. F.

2016-06-01

We have developed a high-resolution x-ray spectrometer for measuring the shapes of spectral lines produced from laser-irradiated targets on the Orion laser facility. The instrument utilizes a spherically bent crystal geometry to spatially focus and spectrally analyze photons from foil or microdot targets. The high photon collection efficiency resulting from its imaging properties allows the instrument to be mounted outside the Orion chamber, where it is far less sensitive to particles, hard x-rays, or electromagnetic pulses than instruments housed close to the target chamber center in ten-inch manipulators. Moreover, Bragg angles above 50° are possible, which provide greatly improved spectral resolution compared to radially viewing, near grazing-incidence crystal spectrometers. These properties make the new instrument an ideal lineshape diagnostic for determining plasma temperature and density. We describe its calibration on the Livermore electron beam ion trap facility and present spectral data of the K-shell emission from highly charged sulfur produced by long-pulse as well as short-pulse beams on the Orion laser in the United Kingdom.

Lineshape spectroscopy with a very high resolution, very high signal-to-noise crystal spectrometer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beiersdorfer, P.; Magee, E. W.; Brown, G. V.

2016-06-15

We have developed a high-resolution x-ray spectrometer for measuring the shapes of spectral lines produced from laser-irradiated targets on the Orion laser facility. The instrument utilizes a spherically bent crystal geometry to spatially focus and spectrally analyze photons from foil or microdot targets. The high photon collection efficiency resulting from its imaging properties allows the instrument to be mounted outside the Orion chamber, where it is far less sensitive to particles, hard x-rays, or electromagnetic pulses than instruments housed close to the target chamber center in ten-inch manipulators. Moreover, Bragg angles above 50° are possible, which provide greatly improved spectralmore » resolution compared to radially viewing, near grazing-incidence crystal spectrometers. These properties make the new instrument an ideal lineshape diagnostic for determining plasma temperature and density. We describe its calibration on the Livermore electron beam ion trap facility and present spectral data of the K-shell emission from highly charged sulfur produced by long-pulse as well as short-pulse beams on the Orion laser in the United Kingdom.« less

Progress in neutron-, X-ray- and VIS spectroscopic diagnostics of large-scale plasma focus experiments at ICDMP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmidt, Hellmut

Substantial progress has been made in various diagnostics for investigating results of experiments during the last years performed with the PF1000 device at IPPLM, Warsaw, Poland. In addition to standard diagnostics of the electrical characteristics of up to 1 MJ discharges in a Mather type plasma focus geometry, such as high speed photography, X-ray, fast electron beam and time-integrated neutron measurements, there have been made among others at least three quite successful efforts recently: 1) Setting up of a neutron time-of-flight line with up to five scintillation detectors including optical fibre based data collection equipment, 2) Use of a Mechellemore » spectrometer with CCD registration and possibility to take time-resolved spectra with resolutions down to 100 ns and 3) Setting up and using pinhole cameras equipped with solid state nuclear track detectors for the detection of fusion generated protons. Correlations of emission events as well as plasma and electrical current dynamics are investigated. Neutron emission characteristics and fusion products production mechanisms are discussed considering a generalized beam target model, called Gyrating Particle Model.« less

High Resolution Spectroscopy and Dynamics: from Jet Cooled Radicals to Gas-Liquid Interfaces

NASA Astrophysics Data System (ADS)

Sharp-Williams, E.; Roberts, M. A.; Roscioli, J. R.; Gisler, A. W.; Ziemkiewicz, M.; Nesbitt, D. J.; Dong, F.; Perkins, B. G., Jr.

2010-06-01

This talk will attempt to reflect recent work in our group involving two quite different but complementary applications of high resolution molecular spectroscopy for detailed study of intramolecular as well as intermolecular dynamics in small molecules. The first is based on direct infrared absorption spectroscopy in a 100 KHz slit supersonic discharge, which provides a remarkably versatile and yet highly sensitive probe for study of important chemical transients such as open shell combustion species and molecular ions under jet cooled (10-20K), sub-Doppler conditions. For this talk will focus on gas phase spectroscopic results for a series of unsaturated hydrocarbon radical species (ethynyl, vinyl, and phenyl) reputed to be critical intermediates in soot formation. Secondly, we will discuss recent applications of high resolution IR and velocity map imaging spectroscopy toward quantum state resolved collision dynamics of jet cooled molecules from gas-room temperature ionic liquid (RTIL) and gas-self assembled monolayer (SAM) interfaces. Time permitting, we will also present new results on hyperthermal scattering of jet cooled NO radical from liquid Ga, which offer a novel window into non-adiabatic energy transfer and electron-hole pair dynamics at the gas-molten metal interface.

New Spectroscopic Solution of the Eclipsing Binary HX Vel A

NASA Astrophysics Data System (ADS)

Sürgit, D.; Erdem, A.; Özkardeş, B.; Butland, R.; Budding, E.

2015-07-01

We present a preliminary analysis of new spectroscopic observations of the southern binary HX Vel A. High-resolution spectroscopic observations were made at the Mt. John University Observatory in 2014. Radial velocities for HX Vel A were determined from the Gaussian profile-fitting method. The Keplerian radial velocity model gives the close binary mass ratio as 0.57±0.06. The resulting orbital elements are a1sin i=0.0086 ±0.0003 au, a2sin i=0.0151 ±0.0003 au, M1 sin3i =0.887 ±0.046 M⊙, and M2 sin3i =0.504 ±0.032 M⊙.

Spectroscopic Study of the Early-Type Binary HX Vel A

NASA Astrophysics Data System (ADS)

Özkardeş, Burcu; Sürgit, Derya; Erdem, Ahmet; Budding, Edwin; Soydugan, Faruk; Demircan, Osman

2012-04-01

This paper presents high resolution spectroscopy of the HX Vel (IDS 08390-4744 AB) multiple system. New spectroscopic observations of the system were made at Mt. John University Observatory in 2007 and 2008. Radial velocities of both components of HX Vel A were measured using gaussian fitting. The spectroscopic mass ratio of the close binary was determined as 0.599+/-0.052, according to a Keplerian orbital solution. The resulting orbital elements are a1sini=0.0098+/-0.0003 AU, a2sini=0.0164+/-0.0003 AU, M1sin3i=1.19+/-0.07 M⊙ and M2sin3i=0.71+/-0.04 M⊙.

High-Resolution Rotational Spectroscopy of a Molecular Rotary Motor

NASA Astrophysics Data System (ADS)

Domingos, Sergio R.; Cnossen, Arjen; Perez, Cristobal; Buma, Wybren Jan; Browne, Wesley R.; Feringa, Ben L.; Schnell, Melanie

2017-06-01

To develop synthetic molecular motors and machinery that can mimic their biological counterparts has become a stimulating quest in modern synthetic chemistry. Gas phase studies of these simpler synthetic model systems provide the necessary isolated conditions that facilitate the elucidation of their structural intricacies. We report the first high-resolution rotational study of a synthetic molecular rotary motor based on chiral overcrowded alkenes using chirp-pulsed Fourier transform microwave spectroscopy. Rotational constants and quartic centrifugal distortion constants were determined based on a fit using more than two hundred rotational transitions spanning 5≤J≤21 in the 2-4 GHz frequency range. Despite the lack of polar groups, the rotor's asymmetry produces strong a- and b-type rotational transitions arising from a single predominant conformer. Evidence for fragmentation of the rotor allows for unambiguous identification of the isolated rotor components. The experimental spectroscopic parameters of the rotor are compared and discussed against current high-level ab initio and density functional theory methods. Vicario et al. Chem. Commun., 5910-5912 (2005) Brown et al. Rev. Sci. Instrum., 79, 053103 (2008)

Low resolution spectroscopy of selected Algol systems

NASA Astrophysics Data System (ADS)

Devarapalli, Shanti Priya; Jagirdar, Rukmini; Parthasarathy, M.; Sahu, D. K.; Mohan, Vijay; Bhatt, B. C.; Thomas, Vineet S.

2018-04-01

The analysis of spectroscopic data for 30 Algol-type binaries is presented. All these systems are short period Algols having primaries with spectral types B and A. Dominant spectral lines were identified for the spectra collected and their equivalent widths were calculated. All the spectra were examined to understand presence of mass transfer, a disk or circumstellar matter and chromospheric emission. We also present first spectroscopic and period study for few Algols and conclude that high resolution spectra within and outside the primary minimum are needed for better understanding of these Algol type close binaries.

Recovering the colour-dependent albedo of exoplanets with high-resolution spectroscopy: from ESPRESSO to the ELT.

NASA Astrophysics Data System (ADS)

Martins, J. H. C.; Figueira, P.; Santos, N. C.; Melo, C.; Garcia Muñoz, A.; Faria, J.; Pepe, F.; Lovis, C.

2018-05-01

The characterization of planetary atmospheres is a daunting task, pushing current observing facilities to their limits. The next generation of high-resolution spectrographs mounted on large telescopes - such as ESPRESSO@VLT and HIRES@ELT - will allow us to probe and characterize exoplanetary atmospheres in greater detail than possible to this point. We present a method that permits the recovery of the colour-dependent reflectivity of exoplanets from high-resolution spectroscopic observations. Determining the wavelength-dependent albedo will provide insight into the chemical properties and weather of the exoplanet atmospheres. For this work, we simulated ESPRESSO@VLT and HIRES@ELT high-resolution observations of known planetary systems with several albedo configurations. We demonstrate how the cross correlation technique applied to theses simulated observations can be used to successfully recover the geometric albedo of exoplanets over a range of wavelengths. In all cases, we were able to recover the wavelength dependent albedo of the simulated exoplanets and distinguish between several atmospheric models representing different atmospheric configurations. In brief, we demonstrate that the cross correlation technique allows for the recovery of exoplanetary albedo functions from optical observations with the next generation of high-resolution spectrographs that will be mounted on large telescopes with reasonable exposure times. Its recovery will permit the characterization of exoplanetary atmospheres in terms of composition and dynamics and consolidates the cross correlation technique as a powerful tool for exoplanet characterization.

Helium beam shadowing for high spatial resolution patterning of antibodies on microstructured diagnostic surfaces

PubMed Central

Cacao, Eliedonna; Sherlock, Tim; Nasrullah, Azeem; Kemper, Steven; Knoop, Jennifer; Kourentzi, Katerina; Ruchhoeft, Paul; Stein, Gila E; Atmar, Robert L; Willson, Richard C

2013-01-01

Abstract We have developed a technique for the high-resolution, self-aligning, and high-throughput patterning of antibody binding functionality on surfaces by selectively changing the reactivity of protein-coated surfaces in specific regions of a workpiece with a beam of energetic helium particles. The exposed areas are passivated with bovine serum albumin (BSA) and no longer bind the antigen. We demonstrate that patterns can be formed (1) by using a stencil mask with etched openings that forms a patterned exposure, or (2) by using angled exposure to cast shadows of existing raised microstructures on the surface to form self-aligned patterns. We demonstrate the efficacy of this process through the patterning of anti-lysozyme, anti-Norwalk virus, and anti-Escherichia coli antibodies and the subsequent detection of each of their targets by the enzyme-mediated formation of colored or silver deposits, and also by binding of gold nanoparticles. The process allows for the patterning of three-dimensional structures by inclining the sample relative to the beam so that the shadowed regions remain unaltered. We demonstrate that the resolution of the patterning process is of the order of hundreds of nanometers, and that the approach is well-suited for high throughput patterning. PMID:24706125

High resolution broad-band spectroscopy in the NIR using the Triplespec externally dispersed interferometer at the Hale telescope

NASA Astrophysics Data System (ADS)

Erskine, David J.; Edelstein, J.; Sirk, M.; Wishnow, E.; Ishikawa, Y.; McDonald, E.; Shourt, W. V.

2014-07-01

High resolution broad-band spectroscopy at near-infrared wavelengths has been performed using externally dis- persed interferometry (EDI) at the Hale telescope at Mt. Palomar. The EDI technique uses a field-widened Michelson interferometer in series with a dispersive spectrograph, and is able to recover a spectrum with a resolution 4 to 10 times higher than the existing grating spectrograph. This method increases the resolution well beyond the classical limits enforced by the slit width and the detector pixel Nyquist limit and, in principle, decreases the effect of pupil variation on the instrument line-shape function. The EDI technique permits arbi- trarily higher resolution measurements using the higher throughput, lower weight, size, and expense of a lower resolution spectrograph. Observations of many stars were performed with the TEDI interferometer mounted within the central hole of the 200 inch primary mirror. Light from the interferometer was then dispersed by the TripleSpec near-infrared echelle spectrograph. Continuous spectra between 950 and 2450 nm with a resolution as high as ~27,000 were recovered from data taken with TripleSpec at a native resolution of ˜2,700. Aspects of data analysis for interferometric spectral reconstruction are described. This technique has applications in im- proving measurements of high-resolution stellar template spectra, critical for precision Doppler velocimetry using conventional spectroscopic methods. A new interferometer to be applied for this purpose at visible wavelengths is under construction.

Characterization of spatially resolved high resolution x-ray spectrometers for HEDP and light-source experiments

NASA Astrophysics Data System (ADS)

Hill, K. W.; Bitter, M.; Delgado-Aparicio, L.; Efthimion, P.; Pablant, N.; Lu, J.; Beiersdorfer, P.; Chen, H.; Magee, E.

2014-10-01

A high resolution 1D imaging x-ray spectrometer concept comprising a spherically bent crystal and a 2D pixelated detector is being optimized for diagnostics of small sources such as high energy density physics (HEDP) and synchrotron radiation or x-ray free electron laser experiments. This instrument is used on tokamak experiments for measurement of spatial profiles of Doppler ion temperature and plasma flow velocity, as well as electron temperature. Laboratory measurements demonstrate a resolving power, E/ ΔE of 10,000 and spatial resolution better than 10 μm. Good performance is obtained for Bragg angles ranging from 23 to 63 degrees. Initial tests of the instrument on HEDP plasmas are being performed with a goal of developing spatially resolved ion and electron temperature diagnostics. This work was performed under the auspices of the US DOE by PPPL under Contract DE-AC02-09CH11466 and by LLNL under Contract DE-AC52-07NA27344.

Very high resolution aerial films

NASA Astrophysics Data System (ADS)

Becker, Rolf

1986-11-01

The use of very high resolution aerial films in aerial photography is evaluated. Commonly used panchromatic, color, and CIR films and their high resolution equivalents are compared. Based on practical experience and systematic investigations, the very high image quality and improved height accuracy that can be achieved using these films are demonstrated. Advantages to be gained from this improvement and operational restrictions encountered when using high resolution film are discussed.

Noise and spectroscopic performance of DEPMOSFET matrix devices for XEUS

NASA Astrophysics Data System (ADS)

Treis, J.; Fischer, P.; Hälker, O.; Herrmann, S.; Kohrs, R.; Krüger, H.; Lechner, P.; Lutz, G.; Peric, I.; Porro, M.; Richter, R. H.; Strüder, L.; Trimpl, M.; Wermes, N.; Wölfel, S.

2005-08-01

DEPMOSFET based Active Pixel Sensor (APS) matrix devices, originally developed to cope with the challenging requirements of the XEUS Wide Field Imager, have proven to be a promising new imager concept for a variety of future X-ray imaging and spectroscopy missions like Simbol-X. The devices combine excellent energy resolution, high speed readout and low power consumption with the attractive feature of random accessibility of pixels. A production of sensor prototypes with 64 x 64 pixels with a size of 75 μm x 75 μm each has recently been finished at the MPI semiconductor laboratory in Munich. The devices are built for row-wise readout and require dedicated control and signal processing electronics of the CAMEX type, which is integrated together with the sensor onto a readout hybrid. A number of hybrids incorporating the most promising sensor design variants has been built, and their performance has been studied in detail. A spectroscopic resolution of 131 eV has been measured, the readout noise is as low as 3.5 e- ENC. Here, the dependence of readout noise and spectroscopic resolution on the device temperature is presented.

High Resolution Spectroscopy to Support Atmospheric Measurements

NASA Technical Reports Server (NTRS)

Venkataraman, Malathy Devi

2006-01-01

The major research activities performed during the cooperative agreement enhanced our spectroscopic knowledge of molecules of atmospheric interest such as H2O (water vapor), O3 (ozone), HCN (hydrogen cyanide), CH4 (methane), NO2 (nitrogen dioxide) and CO (carbon monoxide). The data required for the analyses were obtained from two different Fourier Transform Spectrometers (FTS); one of which is located at the National Solar Observatory (NSO) on Kitt Peak, Arizona and the other instrument is located at the Pacific Northwest National Laboratories (PNNL) at Richland, Washington. The data were analyzed using a modified multispectrum nonlinear least squares fitting algorithm developed by Dr. D. Chris Benner of the College of William and Mary. The results from these studies made significant improvements in the line positons and intensities for these molecules. The measurements of pressure broadening and pressure induced line shift coefficients and the temperature dependence of pressure broadening and pressure induced shift coefficients for hundreds of infrared transitions of HCN, CO3 CH4 and H2O were also performed during this period. Results from these studies have been used for retrievals of stratospheric gas concentration profiles from data collected by several Upper Atmospheric Research Satellite (UARS) infrared instruments as well as in the analysis of high resolution atmospheric spectra such as those acquired by space-based, ground-based, and various balloon- and aircraft-borne experiments. Our results made significant contributions in several updates of the HITRAN (HIgh resolution TRANsmission) spectral line parameters database. This database enjoys worldwide recognition in research involving diversified scientific fields. The research conducted during the period 2003-2006 has resulted in publications given in this paper. In addition to Journal publications, several oral and poster presentations were given at various Scientific conferences within the United States

TH-A-BRF-09: Integration of High-Resolution MRSI Into Glioblastoma Treatment Planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schreibmann, E; Cordova, J; Shu, H

2014-06-15

Purpose: Identification of a metabolite signature that shows significant tumor cell infiltration into normal brain in regions that do not appear abnormal on standard MRI scans would be extremely useful for radiation oncologists to choose optimal regions of brain to treat, and to quantify response beyond the MacDonald criteria. We report on integration of high-resolution magnetic resonance spectroscopic imaging (HR-MRSI) with radiation dose escalation treatment planning to define and target regions at high risk for recurrence. Methods: We propose to supplement standard MRI with a special technique performed on an MRI scanner to measure the metabolite levels within defined volumes.more » Metabolite imaging was acquired using an advanced MRSI technique combining 3D echo-planar spectroscopic imaging (EPSI) with parallel acquisition (GRAPPA) using a multichannel head coil that allows acquisition of whole brain metabolite maps with 108 μl resolution in 12 minutes implemented on a 3T MR scanner. Elevation in the ratio of two metabolites, choline (Cho, elevated in proliferating high-grade gliomas) and N-acetyl aspartate (NAA, a normal neuronal metabolite), was used to image infiltrating high-grade glioma cells in vivo. Results: The metabolite images were co-registered with standard contrast-enhanced T1-weighted MR images using in-house registration software and imported into the treatment-planning system. Regions with tumor infiltration are identified on the metabolic images and used to create adaptive IMRT plans that deliver a standard dose of 60 Gy to the standard target volume and an escalated dose of 75 Gy (or higher) to the most suspicious regions, identified as areas with elevated Cho/NAA ratio. Conclusion: We have implemented a state-of-the-art HR-MRSI technology that can generate metabolite maps of the entire brain in a clinically acceptable scan time, coupled with introduction of an imaging co-registration/ analysis program that combines MRSI data with standard

The Galactic O-Star Spectroscopic Survey (GOSSS): new results from the southern stars

NASA Astrophysics Data System (ADS)

Sota, A.; Maíz Apellániz, J.; Barbá, R. H.; Walborn, N. R.; Alfaro, E. J.; Gamen, R. C.; Morrell, N. I.; Arias, J. I.; Penadés Ordaz, M.

2013-05-01

The Galactic O-Star Spectroscopic Survey (GOSSS) is a project that will observe all known Galactic O stars with B < 14 in the blue-violet part of the spectrum with R ˜ 3000. It is based on v2.0 of the the most complete Galactic O star catalog with accurate spectral types (Maíz Apellániz et al. 2004, ApJS, 151, 103; Sota et al. 2008, RevMexAA Conf. Series, 33, 55) that we have recently compiled. We have completed the first part of the main project and recently published the first articles (Walborn et al. 2010, ApJ, 711, 143; Walborn et al. 2011, AJ, 142, 150; Sota et al. 2011, ApJS, 193, 24). GOSSS is part of a bigger project with the next companion surveys: High resolution spectroscopic surveys: OWN, IACOB, IACOB-sweG, NoMaDS, CAFÉ-BEANS High resolution imaging surveys: Astralux, Astralux Sur.

Stimulated Raman scattering (SRS) spectroscopic OCT (Conference Presentation)

NASA Astrophysics Data System (ADS)

Robles, Francisco E.; Zhou, Kevin C.; Fischer, Martin C.; Warren, Warren S.

2017-02-01

Optical coherence tomography (OCT) enables non-invasive, high-resolution, tomographic imaging of biological tissues by leveraging principles of low coherence interferometry; however, OCT lacks molecular specificity. Spectroscopic OCT (SOCT) overcomes this limitation by providing depth-resolved spectroscopic signatures of chromophores, but SOCT has been limited to a couple of endogenous molecules, namely hemoglobin and melanin. Stimulated Raman scattering, on the other hand, can provide highly specific molecular information of many endogenous species, but lacks the spatial and spectral multiplexing capabilities of SOCT. In this work we integrate the two methods, SRS and SOCT, to enable simultaneously multiplexed spatial and spectral imaging with sensitivity to many endogenous biochemical species that play an important role in biology and medicine. The method, termed SRS-SOCT, has the potential to achieve fast, volumetric, and highly sensitive label-free molecular imaging, which would be valuable for many applications. We demonstrate the approach by imaging excised human adipose tissue and detecting the lipids' Raman signatures in the high-wavenumber region. Details of this method along with validations and results will be presented.

High-resolution threshold photoionization of N sub 2 O

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiedmann, R.T.; Grant, E.R.; Tonkyn, R.G.

1991-07-15

Pulsed field ionization (PFI) has been used in conjunction with a coherent vuv source to obtain high-resolution threshold photoelectron spectra for the (000), (010), (020), and (100) vibrational states of the N{sub 2}O{sup +} cation. Simulations for the rotational profiles of each vibronic level were obtained by fitting the Buckingham--Orr--Sichel equations (A. D. Buckingham, B. J. Orr, and J. M. Sichel, Philos. Trans. R. Soc. London, Ser. A {bold 268}, 147 (1970)) using accurate spectroscopic constants for the ground states of the neutral and the ion. The relative branch intensities are interpreted in terms of the partial waves of themore » outgoing photoelectron to which the ionic core is coupled and in terms of the angular momentum transferred to the core. The PFI technique also allows us to report an improved value for the ionization potential of N{sub 2}O of 103 963{plus minus}5 cm{sup {minus}1}.« less

Evaluation of Heterogeneous Metabolic Profile in an Orthotopic Human Glioblastoma Xenograft Model Using Compressed Sensing Hyperpolarized 3D 13C Magnetic Resonance Spectroscopic Imaging

PubMed Central

Park, Ilwoo; Hu, Simon; Bok, Robert; Ozawa, Tomoko; Ito, Motokazu; Mukherjee, Joydeep; Phillips, Joanna J.; James, C. David; Pieper, Russell O.; Ronen, Sabrina M.; Vigneron, Daniel B.; Nelson, Sarah J.

2013-01-01

High resolution compressed sensing hyperpolarized 13C magnetic resonance spectroscopic imaging was applied in orthotopic human glioblastoma xenografts for quantitative assessment of spatial variations in 13C metabolic profiles and comparison with histopathology. A new compressed sensing sampling design with a factor of 3.72 acceleration was implemented to enable a factor of 4 increase in spatial resolution. Compressed sensing 3D 13C magnetic resonance spectroscopic imaging data were acquired from a phantom and 10 tumor-bearing rats following injection of hyperpolarized [1-13C]-pyruvate using a 3T scanner. The 13C metabolic profiles were compared with hematoxylin and eosin staining and carbonic anhydrase 9 staining. The high-resolution compressed sensing 13C magnetic resonance spectroscopic imaging data enabled the differentiation of distinct 13C metabolite patterns within abnormal tissues with high specificity in similar scan times compared to the fully sampled method. The results from pathology confirmed the different characteristics of 13C metabolic profiles between viable, non-necrotic, nonhypoxic tumor, and necrotic, hypoxic tissue. PMID:22851374

Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging.

PubMed

Park, Ilwoo; Hu, Simon; Bok, Robert; Ozawa, Tomoko; Ito, Motokazu; Mukherjee, Joydeep; Phillips, Joanna J; James, C David; Pieper, Russell O; Ronen, Sabrina M; Vigneron, Daniel B; Nelson, Sarah J

2013-07-01

High resolution compressed sensing hyperpolarized (13)C magnetic resonance spectroscopic imaging was applied in orthotopic human glioblastoma xenografts for quantitative assessment of spatial variations in (13)C metabolic profiles and comparison with histopathology. A new compressed sensing sampling design with a factor of 3.72 acceleration was implemented to enable a factor of 4 increase in spatial resolution. Compressed sensing 3D (13)C magnetic resonance spectroscopic imaging data were acquired from a phantom and 10 tumor-bearing rats following injection of hyperpolarized [1-(13)C]-pyruvate using a 3T scanner. The (13)C metabolic profiles were compared with hematoxylin and eosin staining and carbonic anhydrase 9 staining. The high-resolution compressed sensing (13)C magnetic resonance spectroscopic imaging data enabled the differentiation of distinct (13)C metabolite patterns within abnormal tissues with high specificity in similar scan times compared to the fully sampled method. The results from pathology confirmed the different characteristics of (13)C metabolic profiles between viable, non-necrotic, nonhypoxic tumor, and necrotic, hypoxic tissue. Copyright © 2012 Wiley Periodicals, Inc.

A Virtual Study of Grid Resolution on Experiments of a Highly-Resolved Turbulent Plume

NASA Astrophysics Data System (ADS)

Maisto, Pietro M. F.; Marshall, Andre W.; Gollner, Michael J.; Fire Protection Engineering Department Collaboration

2017-11-01

An accurate representation of sub-grid scale turbulent mixing is critical for modeling fire plumes and smoke transport. In this study, PLIF and PIV diagnostics are used with the saltwater modeling technique to provide highly-resolved instantaneous field measurements in unconfined turbulent plumes useful for statistical analysis, physical insight, and model validation. The effect of resolution was investigated employing a virtual interrogation window (of varying size) applied to the high-resolution field measurements. Motivated by LES low-pass filtering concepts, the high-resolution experimental data in this study can be analyzed within the interrogation windows (i.e. statistics at the sub-grid scale) and on interrogation windows (i.e. statistics at the resolved scale). A dimensionless resolution threshold (L/D*) criterion was determined to achieve converged statistics on the filtered measurements. Such a criterion was then used to establish the relative importance between large and small-scale turbulence phenomena while investigating specific scales for the turbulent flow. First order data sets start to collapse at a resolution of 0.3D*, while for second and higher order statistical moments the interrogation window size drops down to 0.2D*.

High-Resolution Infrared Spectroscopic Observations of the Upper Scorpius Eclipsing Binary EPIC 203868608

NASA Astrophysics Data System (ADS)

Johnson, Marshall C.; Mace, Gregory N.; Kim, Hwihyun; Kaplan, Kyle; McLane, Jacob; Sokal, Kimberly R.

2017-06-01

EPIC 203868608 is a source in the ~10 Myr old Upper Scorpius OB association. Using K2 photometry and ground-based follow-up observations, David et al. (2016) found that it consists of two brown dwarfs with a tertiary object at a projected separation of ~20 AU; the former objects appear to be a double-lined eclipsing binary with a period of 4.5 days. This is one of only two known eclipsing SB2s where both components are below the hydrogen-burning limit. We present additional follow-up observations of this system from the IGRINS high-resolution near-infrared spectrograph at McDonald Observatory. Our measured radial velocities do not follow the orbital solution presented by David et al. (2016). Instead, our combined IGRINS plus literature radial velocity dataset appears to indicate a period significantly different than that of the eclipsing binary obvious from the K2 light curve. We will discuss possible scenarios to account for the conflicting observations of this system.

Development of a High-Pressure Gaseous Burner for Calibrating Optical Diagnostic Techniques

NASA Technical Reports Server (NTRS)

Kojima, Jun; Nguyen, Quang-Viet

2003-01-01

In this work-in-progress report, we show the development of a unique high-pressure burner facility (up to 60 atm) that provides steady, reproducible premixed flames with high precision, while having the capability to use multiple fuel/oxidizer combinations. The highpressure facility has four optical access ports for applying different laser diagnostic techniques and will provide a standard reference flame for the development of a spectroscopic database in high-pressure/temperature conditions. Spontaneous Raman scattering (SRS) was the first diagnostic applied, and was used to successfully probe premixed hydrogen-air flames generated in the facility using a novel multi-jet micro-premixed array burner element. The SRS spectral data include contributions from H2, N2, O2, and H2O and were collected over a wide range of equivalence ratios ranging from 0.16 to 4.9 at an initial pressure of 10-atm via a spatially resolved point SRS measurement with a high-performance optical system. Temperatures in fuel-lean to stoichiometric conditions were determined from the ratio of the Stokes to anti-Stokes scattering of the Q-branch of N2, and those in fuel-rich conditions via the rotational temperature of H2. The SRS derived temperatures using both techniques were consistent and indicated that the flame temperature was approximately 500 K below that predicted by adiabatic equilibrium, indicating a large amount of heat-loss at the measurement zone. The integrated vibrational SRS signals show that SRS provides quantitative number density data in high-pressure H2-air flames.

A high resolution spectroscopic study of the oxygen molecule. Ph.D. Thesis Final Report

NASA Technical Reports Server (NTRS)

Ritter, K. J.

1984-01-01

A high resolution spectrometer which incorporates a narrow line width tunable dye laser was used to make absorption profiles of 57 spectral lines in the Oxygen A-Band at pressures up to one atmosphere in pure O2. The observed line profiles are compared to the Voigt, and a collisionally narrowed, profile using a least squares fitting procedure. The collisionally narrowed profile compares more favorable to the observed profiles. Values of the line strengths and self broadening coeffiencients, determined from the least square fitting process, are presented in tabular form. It is found that the experssion by Watson are in closest agreement with the experimentally determined strengths. The self broadening coefficients are compared with the measurements of several other investigators.

Spectroscopic monitoring of bright A-F type candidate hybrid stars discovered by the Kepler mission

NASA Astrophysics Data System (ADS)

Lampens, Patricia; Frémat, Y.; Vermeylen, Lore; De Cat, Peter; Dumortier, Louis; Sódor, Ádám; Sharka, Marek; Bognár, Zsófia

2018-04-01

We report on a study of 250 optical spectra for 50 bright A/F-type candidate hybrid pulsating stars from the Kepler field. Most of the spectra have been collected with the high-resolution spectrograph HERMES attached to the Mercator telescope, La Palma. We determined the radial velocities (RVs), projected rotational velocities, fundamental atmospheric parameters and provide a classification based on the appearance of the cross-correlation profiles and the behaviour of the RVs with time in order to find true hybrid pulsators. Additionally, we also detected new spectroscopic binary and multiple systems in our sample and determined the fraction of spectroscopic systems. In order to be able to extend this investigation to the fainter A-F type candidate hybrid stars, various high-quality spectra collected with 3-4 m sized telescopes suitably equipped with a high-resolution spectrograph and furthermore located in the Northern hemisphere would be ideal. This programme could be done using the new instruments installed at the Devasthal Observatory.

Diagnostic accuracy of transabdominal high-resolution US for staging gallbladder cancer and differential diagnosis of neoplastic polyps compared with EUS.

PubMed

Lee, Jeong Sub; Kim, Jung Hoon; Kim, Yong Jae; Ryu, Ji Kon; Kim, Yong-Tae; Lee, Jae Young; Han, Joon Koo

2017-07-01

To compare the diagnostic accuracy of transabdominal high-resolution ultrasound (HRUS) for staging gallbladder cancer and differential diagnosis of neoplastic polyps compared with endoscopic ultrasound (EUS) and pathology. Among 125 patients who underwent both HRUS and EUS, we included 29 pathologically proven cancers (T1 = 7, T2 = 19, T3 = 3) including 15 polypoid cancers and 50 surgically proven polyps (neoplastic = 30, non-neoplastic = 20). We reviewed formal reports and assessed the accuracy of HRUS and EUS for diagnosing cancer as well as the differential diagnosis of neoplastic polyps. Statistical analyses were performed using chi-square tests. The sensitivity, specificity, PPV, and NPV for gallbladder cancer were 82.7 %, 44.4 %, 82.7 %, and 44 % using HRUS and 86.2 %, 22.2 %, 78.1 %, and 33.3 % using EUS. HRUS and EUS correctly diagnosed the stage in 13 and 12 patients. The sensitivity, specificity, PPV, and NPV for neoplastic polyps were 80 %, 80 %, 86 %, and 73 % using HRUS and 73 %, 85 %, 88 %, and 69 % using EUS. Single polyps (8/20 vs. 21/30), larger (1.0 ± 0.28 cm vs. 1.9 ± 0.85 cm) polyps, and older age (52.5 ± 13.2 vs. 66.1 ± 10.3 years) were common in neoplastic polyps (p < 0.05). Transabdominal HRUS showed comparable accuracy for diagnosing gallbladder cancer and differentiating neoplastic polyps compared with EUS. HRUS is also easy to use during our routine ultrasound examinations. • HRUS showed comparable diagnostic accuracy for GB cancer compared with EUS. • HRUS and EUS showed similar diagnostic accuracy for differentiating neoplastic polyps. • Single, larger polyps and older age were common in neoplastic polyps. • HRUS is less invasive compared with EUS.

High-Resolution Radar Imagery of Mars

NASA Astrophysics Data System (ADS)

Harmon, John K.; Nolan, M. C.

2009-09-01

We present high-resolution radar images of Mars obtained during the 2005 and 2007 oppositions. The images were constructed from long-code delay-Doppler observations made with the Arecibo S-band (13-cm) radar. The average image resolution of 3 km represented a better than order-of-magnitude improvement over pre-upgrade Arecibo imagery of the planet. Images of depolarized reflectivity (an indicator primarily of wavelength-scale surface roughness) show the same bright volcanic flow features seen in earlier imagery, but with much finer detail. A new image of the Elysium region shows fine detail in the radar-bright channels of Athabasca Vallis, Marte Vallis, and Grjota Vallis. The new images of Tharsis and Olympus Mons also show a complex array of radar-bright and radar-dark features. Southern Amazonis exhibits some of the most complex and puzzling radar-bright structure on the planet. Another curiosity is the Chryse/Xanthe/Channels region, where we find some radar-bright features in or adjacent to fluvial chaos structures. Chryse/Xanthe is also the only region of Mars showing radar-bright craters (which are rare on Mars but common on the Moon and Mercury). We also obtained the first delay-Doppler image showing the enhanced backscatter from the residual south polar ice cap. In addition to the depolarized imagery, we were able to make the first delay-Doppler images of the circular polarization ratio (an important diagnostic for surface roughness texture). We find that vast areas of the radar-bright volcanic regions have polarization ratios close to unity. Such high ratios are rare for terrestrial lava flows and only seen for extremely blocky surfaces giving high levels of multiple scattering.

Detection of High-Frequency Oscillations and Damping from Multi-slit Spectroscopic Observations of the Corona

NASA Astrophysics Data System (ADS)

Samanta, T.; Singh, J.; Sindhuja, G.; Banerjee, D.

2016-01-01

During the total solar eclipse of 11 July 2010, multi-slit spectroscopic observations of the solar corona were performed from Easter Island, Chile. To search for high-frequency waves, observations were taken at a high cadence in the green line at 5303 Å that is due to [Fe xiv] and the red line at 6374 Å that is due to [Fe x]. The data were analyzed to study the periodic variations in intensity, Doppler velocity, and line width using wavelet analysis. The data with high spectral and temporal resolution enabled us to study the rapid dynamical changes within coronal structures. We find that at certain locations, each parameter shows significant oscillation with periods ranging from 6 - 25 s. For the first time, we were able to detect damping of high-frequency oscillations with periods of about 10 s. If the observed damped oscillations are due to magnetohydrodynamic waves, then they can contribute significantly to the heating of the corona. From a statistical study we try to characterize the nature of the observed oscillations while considering the distribution of power in different line parameters.

The HITRAN2016 molecular spectroscopic database

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gordon, I. E.; Rothman, L. S.; Hill, C.

This paper describes the contents of the 2016 edition of the HITRAN molecular spectroscopic compilation. The new edition replaces the previous HITRAN edition of 2012 and its updates during the intervening years. The HITRAN molecular absorption compilation is comprised of five major components: the traditional line-by-line spectroscopic parameters required for high-resolution radiative-transfer codes, infrared absorption cross-sections for molecules not yet amenable to representation in a line-by-line form, collision-induced absorption data, aerosol indices of refraction, and general tables such as partition sums that apply globally to the data. The new HITRAN is greatly extended in terms of accuracy, spectral coverage, additionalmore » absorption phenomena, added line-shape formalisms, and validity. Moreover, molecules, isotopologues, and perturbing gases have been added that address the issues of atmospheres beyond the Earth. Of considerable note, experimental IR cross-sections for almost 200 additional significant molecules have been added to the database.« less

Highly Accurate Quartic Force Fields, Vibrational Frequencies, and Spectroscopic Constants for Cyclic and Linear C3H3(+)

NASA Technical Reports Server (NTRS)

Huang, Xinchuan; Taylor, Peter R.; Lee, Timothy J.

2011-01-01

High levels of theory have been used to compute quartic force fields (QFFs) for the cyclic and linear forms of the C H + molecular cation, referred to as c-C H + and I-C H +. Specifically the 33 3333 singles and doubles coupled-cluster method that includes a perturbational estimate of connected triple excitations, CCSD(T), has been used in conjunction with extrapolation to the one-particle basis set limit and corrections for scalar relativity and core correlation have been included. The QFFs have been used to compute highly accurate fundamental vibrational frequencies and other spectroscopic constants using both vibrational 2nd-order perturbation theory and variational methods to solve the nuclear Schroedinger equation. Agreement between our best computed fundamental vibrational frequencies and recent infrared photodissociation experiments is reasonable for most bands, but there are a few exceptions. Possible sources for the discrepancies are discussed. We determine the energy difference between the cyclic and linear forms of C H +, 33 obtaining 27.9 kcal/mol at 0 K, which should be the most reliable available. It is expected that the fundamental vibrational frequencies and spectroscopic constants presented here for c-C H + 33 and I-C H + are the most reliable available for the free gas-phase species and it is hoped that 33 these will be useful in the assignment of future high-resolution laboratory experiments or astronomical observations.

Extreme ultraviolet spectroscopy diagnostics of low-temperature plasmas based on a sliced multilayer grating and glass capillary optics.

PubMed

Kantsyrev, V L; Safronova, A S; Williamson, K M; Wilcox, P; Ouart, N D; Yilmaz, M F; Struve, K W; Voronov, D L; Feshchenko, R M; Artyukov, I A; Vinogradov, A V

2008-10-01

New extreme ultraviolet (EUV) spectroscopic diagnostics of relatively low-temperature plasmas based on the application of an EUV spectrometer and fast EUV diodes combined with glass capillary optics is described. An advanced high resolution dispersive element sliced multilayer grating was used in the compact EUV spectrometer. For monitoring of the time history of radiation, filtered fast EUV diodes were used in the same spectral region (>13 nm) as the EUV spectrometer. The radiation from the plasma was captured by using a single inexpensive glass capillary that was transported onto the spectrometer entrance slit and EUV diode. The use of glass capillary optics allowed placement of the spectrometer and diodes behind the thick radiation shield outside the direction of a possible hard x-ray radiation beam and debris from the plasma source. The results of the testing and application of this diagnostic for a compact laser plasma source are presented. Examples of modeling with parameters of plasmas are discussed.

Solar flare microwave observations with high spectral resolution

NASA Astrophysics Data System (ADS)

Bruggmann, G.; Magun, A.; Benz, A. O.; Stehling, W.

1990-12-01

The solar flare radio emission in the 6-8 GHz range was observed with a high resolution spectrometer. The observed band corresponds to the plasma frequencies and gyrofrequencies of the transition region and the lowest part of the corona in active regions. Most of the emissions were found to be broadbanded, as expected from the gyrosynchrotron mechanism. In eight out of 46 observed events, spectral structures of three types were detected: spikes below the time resolution of 100 ms, slowly drifting broadband structures, and a narrow bandwidth patch of continuum emission. These first narrowband bursts spectrally recorded in the 6-8 GHz range are generally weak. Slowly drifting structures are the only type compatible with the gyrosynchrotron emission mechanism. A simple argument based on free-free absorption shows that plasma emission can only be propagated if the radiation originates in a dense region with a small density-scale length. The same holds for maser emission at a low harmonic of the electron gyrofrequency. Possible emission mechanisms and diagnostic capabilities are discussed.

Optimization design of spectral discriminator for high-spectral-resolution lidar based on error analysis.

PubMed

Di, Huige; Zhang, Zhanfei; Hua, Hangbo; Zhang, Jiaqi; Hua, Dengxin; Wang, Yufeng; He, Tingyao

2017-03-06

Accurate aerosol optical properties could be obtained via the high spectral resolution lidar (HSRL) technique, which employs a narrow spectral filter to suppress the Rayleigh or Mie scattering in lidar return signals. The ability of the filter to suppress Rayleigh or Mie scattering is critical for HSRL. Meanwhile, it is impossible to increase the rejection of the filter without limitation. How to optimize the spectral discriminator and select the appropriate suppression rate of the signal is important to us. The HSRL technology was thoroughly studied based on error propagation. Error analyses and sensitivity studies were carried out on the transmittance characteristics of the spectral discriminator. Moreover, ratwo different spectroscopic methods for HSRL were described and compared: one is to suppress the Mie scattering; the other is to suppress the Rayleigh scattering. The corresponding HSRLs were simulated and analyzed. The results show that excessive suppression of Rayleigh scattering or Mie scattering in a high-spectral channel is not necessary if the transmittance of the spectral filter for molecular and aerosol scattering signals can be well characterized. When the ratio of transmittance of the spectral filter for aerosol scattering and molecular scattering is less than 0.1 or greater than 10, the detection error does not change much with its value. This conclusion implies that we have more choices for the high-spectral discriminator in HSRL. Moreover, the detection errors of HSRL regarding the two spectroscopic methods vary greatly with the atmospheric backscattering ratio. To reduce the detection error, it is necessary to choose a reasonable spectroscopic method. The detection method of suppressing the Rayleigh signal and extracting the Mie signal can achieve less error in a clear atmosphere, while the method of suppressing the Mie signal and extracting the Rayleigh signal can achieve less error in a polluted atmosphere.

High sensitivity far infrared laser diagnostics for the C-2U advanced beam-driven field-reversed configuration plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deng, B. H., E-mail: bdeng@trialphaenergy.com; Beall, M.; Schroeder, J.

2016-11-15

A high sensitivity multi-channel far infrared laser diagnostics with switchable interferometry and polarimetry operation modes for the advanced neutral beam-driven C-2U field-reversed configuration (FRC) plasmas is described. The interferometer achieved superior resolution of 1 × 10{sup 16} m{sup −2} at >1.5 MHz bandwidth, illustrated by measurement of small amplitude high frequency fluctuations. The polarimetry achieved 0.04° instrument resolution and 0.1° actual resolution in the challenging high density gradient environment with >0.5 MHz bandwidth, making it suitable for weak internal magnetic field measurements in the C-2U plasmas, where the maximum Faraday rotation angle is less than 1°. The polarimetry resolution datamore » is analyzed, and high resolution Faraday rotation data in C-2U is presented together with direct evidences of field reversal in FRC magnetic structure obtained for the first time by a non-perturbative method.« less

High-Resolution Spectroscopy with the Chandra X-ray Observatory

ScienceCinema

Canizares, Claude R. [MIT, Cambridge, Massachusetts, United States

2017-12-09

The capabilities of the Chandra X-ray Observatory and XMM-Newton for high-resolution spectroscopy have brought tradition plasma diagnostic techniques to the study of cosmic plasma. Observations have probed nearly every class of astronomical object, from young proto-starts through massive O starts and black hole binaries, supernova remnants, active galactic nuclei, and the intergalactic medium. Many of these sources show remarkable rich spectra that reveal new physical information, such as emission measure distributions, elemental abundances, accretion disk and wind signatures, and time variability. This talk will present an overview of the Chandra instrumentaton and selected examples of spectral observations of astrophysical and cosmological importance.

Low resolution spectroscopic investigation of Am stars using Automated method

NASA Astrophysics Data System (ADS)

Sharma, Kaushal; Joshi, Santosh; Singh, Harinder P.

2018-04-01

The automated method of full spectrum fitting gives reliable estimates of stellar atmospheric parameters (Teff, log g and [Fe/H]) for late A, F, G, and early K type stars. Recently, the technique was further improved in the cooler regime and the validity range was extended up to a spectral type of M6 - M7 (Teff˜ 2900 K). The present study aims to explore the application of this method on the low-resolution spectra of Am stars, a class of chemically peculiar stars, to examine its robustness for these objects. We use ULySS with the Medium-resolution INT Library of Empirical Spectra (MILES) V2 spectral interpolator for parameter determination. The determined Teff and log g values are found to be in good agreement with those obtained from high-resolution spectroscopy.

The California-Kepler Survey. I. High-resolution Spectroscopy of 1305 Stars Hosting Kepler Transiting Planets

NASA Astrophysics Data System (ADS)

Petigura, Erik A.; Howard, Andrew W.; Marcy, Geoffrey W.; Johnson, John Asher; Isaacson, Howard; Cargile, Phillip A.; Hebb, Leslie; Fulton, Benjamin J.; Weiss, Lauren M.; Morton, Timothy D.; Winn, Joshua N.; Rogers, Leslie A.; Sinukoff, Evan; Hirsch, Lea A.; Crossfield, Ian J. M.

2017-09-01

The California-Kepler Survey (CKS) is an observational program developed to improve our knowledge of the properties of stars found to host transiting planets by NASA’s Kepler Mission. The improvement stems from new high-resolution optical spectra obtained using HIRES at the W. M. Keck Observatory. The CKS stellar sample comprises 1305 stars classified as Kepler objects of interest, hosting a total of 2075 transiting planets. The primary sample is magnitude-limited ({Kp}< 14.2) and contains 960 stars with 1385 planets. The sample was extended to include some fainter stars that host multiple planets, ultra-short period planets, or habitable zone planets. The spectroscopic parameters were determined with two different codes, one based on template matching and the other on direct spectral synthesis using radiative transfer. We demonstrate a precision of 60 K in {T}{eff}, 0.10 dex in {log}g, 0.04 dex in [{Fe}/{{H}}], and 1.0 {km} {{{s}}}-1 in V\\sin I. In this paper, we describe the CKS project and present a uniform catalog of spectroscopic parameters. Subsequent papers in this series present catalogs of derived stellar properties such as mass, radius, and age; revised planet properties; and statistical explorations of the ensemble. CKS is the largest survey to determine the properties of Kepler stars using a uniform set of high-resolution, high signal-to-noise ratio spectra. The HIRES spectra are available to the community for independent analyses. Based on observations obtained at the W. M. Keck Observatory, which is operated jointly by the University of California and the California Institute of Technology. Keck time was granted for this project by the University of California, and California Institute of Technology, the University of Hawaii, and NASA.

Massive Young Stellar Objects in the Galactic Center. 1; Spectroscopic Identification from Spitzer/IRS Observations

NASA Technical Reports Server (NTRS)

An, Deokkeun; Ramirez, Solange V.; Sellgren, Kris; Arendt, Richard G.; Boogert, A. C. Adwin; Robitaille, Thomas P.; Schultheis, Mathias; Cotera, Angela S.; Smith, Howard A.; Stolovy, Susan R.

2011-01-01

We present results from our spectroscopic study, using the Infrared Spectrograph (IRS) onboard the Spitzer Space Telescope, designed to identify massive young stellar objects (YSOs) in the Galactic Center (GC). Our sample of 107 YSO candidates was selected based on IRAC colors from the high spatial resolution, high sensitivity Spitzer/IRAC images in the Central Molecular Zone (CMZ), which spans the central approximately 300 pc region of the Milky Way Galaxy. We obtained IRS spectra over 5 micron to 35 micron using both high- and low-resolution IRS modules. We spectroscopically identify massive YSOs by the presence of a 15.4 micron shoulder on the absorption profile of 15 micron CO2 ice, suggestive of CO2 ice mixed with CH30H ice on grains. This 15.4 micron shoulder is clearly observed in 16 sources and possibly observed in an additional 19 sources. We show that 9 massive YSOs also reveal molecular gas-phase absorption from C02, C2H2, and/or HCN, which traces warm and dense gas in YSOs. Our results provide the first spectroscopic census of the massive YSO population in the GC. We fit YSO models to the observed spectral energy distributions and find YSO masses of 8 - 23 solar Mass, which generally agree with the masses derived from observed radio continuum emission. We find that about 50% of photometrically identified YSOs are confirmed with our spectroscopic study. This implies a preliminary star formation rate of approximately 0.07 solar mass/yr at the GC.

High resolution Physio-chemical Tissue Analysis: Towards Non-invasive In Vivo Biopsy

NASA Astrophysics Data System (ADS)

Xu, Guan; Meng, Zhuo-Xian; Lin, Jian-Die; Deng, Cheri X.; Carson, Paul L.; Fowlkes, J. Brian; Tao, Chao; Liu, Xiaojun; Wang, Xueding

2016-02-01

Conventional gold standard histopathologic diagnosis requires information of both high resolution structural and chemical changes in tissue. Providing optical information at ultrasonic resolution, photoacoustic (PA) technique could provide highly sensitive and highly accurate tissue characterization noninvasively in the authentic in vivo environment, offering a replacement for histopathology. A two-dimensional (2D) physio-chemical spectrogram (PCS) combining micrometer to centimeter morphology and chemical composition simultaneously can be generated for each biological sample with PA measurements at multiple optical wavelengths. This spectrogram presents a unique 2D “physio-chemical signature” for any specific type of tissue. Comprehensive analysis of PCS, termed PA physio-chemical analysis (PAPCA), can lead to very rich diagnostic information, including the contents of all relevant molecular and chemical components along with their corresponding histological microfeatures, comparable to those accessible by conventional histology. PAPCA could contribute to the diagnosis of many diseases involving diffusive patterns such as fatty liver.

The ESA FELYX High Resolution Diagnostic Data Set System Design and Implementation

NASA Astrophysics Data System (ADS)

Taberner, M.; Shutler, J.; Walker, P.; Poulter, D.; Piolle, J.-F.; Donlon, C.; Guidetti, V.

2013-10-01

Felyx is currently under development and is the latest evolution of a generalised High Resolution Diagnostic Data Set system funded by ESA. It draws on previous prototype developments and experience in the GHRSST, Medspiration, GlobColour and GlobWave projects. In this paper, we outline the design and implementation of the system, and illustrate using the Ocean Colour demonstration activities. Felyx is fundamentally a tool to facilitate the analysis of EO data: it is being developed by IFREMER, PML and Pelamis. It will be free software written in python and javascript. The aim is to provide Earth Observation data producers and users with an opensource, flexible and reusable tool to allow the quality and performance of data streams from satellite, in situ and model sources to be easily monitored and studied. New to this project, is the ability to establish and incorporate multi-sensor match-up database capabilities. The systems will be deployable anywhere and even include interaction mechanisms between the deployed instances. The primary concept of Felyx is to work as an extraction tool. It allows for the extraction of subsets of source data over predefined target areas(which can be static or moving). These data subsets, and associated metrics, can then be accessed by users or client applications either as raw files or through automatic alerts. These data can then be used to generate periodic reports or be used for statistical analysis and visualisation through a flexible web interface. Felyx can be used for subsetting, the generation of statistics, the generation of reports or warnings/alerts, and in-depth analyses, to name a few. There are many potential applications but important uses foreseen are: * monitoring and assessing the quality of Earth observations (e.g. satellite products and time series) through statistical analysis and/or comparison with other data sources * assessing and inter-comparing geophysical inversion algorithms * observing a given phenomenon

Spectroscopic Diagnostics of Electric Fields in the Plasma of Current Sheets

NASA Astrophysics Data System (ADS)

Gavrilenko, Valeri; Kyrie, Natalya P.; Frank, Anna G.; Oks, Eugene

2004-11-01

Spectroscopic measurements of electric fields (EFs) in current sheet plasmas were performed in the CS-3D device. The device is intended to study the evolution of current sheets and the magnetic reconnection phenomena. We used the broadening of spectral lines (SLs) of HeII ions for diagnostics of EFs in the current sheet middle plane, and the broadening of SLs of HeI atoms for detection of EFs in the current sheet peripheral regions. For detection of EFs in current sheet plasma, we used SLs of HeII ions at 468.6; 320.3 and 656.0 nm, as well as SLs of HeI atoms at 667.8; 587.6; 492.2 and 447.1 nm. The latter two lines are of a special interest since their profiles include the dipole-forbidden components along with the allowed components. The experimental data have been analyzed by using the numerical calculations based on the Model Microfield Method. The maximum plasma density in the middle of the sheet was in the range (2-8) × 10^16 cm-3, the density in the peripheral regions was (1-2)×10^15 cm-3, and the strength of the quasi-one-dimensional anomalous electric fields in the peripheral regions reached the value of 100 kV/cm. Supported by CRDF, grant RU-P1-2594-MO-04; by the RFBR, grant 03-02-17282; and by the ISTC, project 2098.

Development of silicon grisms and immersion gratings for high-resolution infrared spectroscopy

NASA Astrophysics Data System (ADS)

Ge, Jian; McDavitt, Daniel L.; Bernecker, John L.; Miller, Shane; Ciarlo, Dino R.; Kuzmenko, Paul J.

2002-01-01

We report new results on silicon grism and immersion grating development using photolithography and anisotropic chemical etching techniques, which include process recipe finding, prototype grism fabrication, lab performance evaluation and initial scientific observations. The very high refractive index of silicon (n=3.4) enables much higher dispersion power for silicon-based gratings than conventional gratings, e.g. a silicon immersion grating can offer a factor of 3.4 times the dispersion of a conventional immersion grating. Good transmission in the infrared (IR) allows silicon-based gratings to operate in the broad IR wavelength regions (~1- 10 micrometers and far-IR), which make them attractive for both ground and space-based spectroscopic observations. Coarser gratings can be fabricated with these new techniques rather than conventional techniques, allowing observations at very high dispersion orders for larger simultaneous wavelength coverage. We have found new etching techniques for fabricating high quality silicon grisms with low wavefront distortion, low scattered light and high efficiency. Particularly, a new etching process using tetramethyl ammonium hydroxide (TMAH) is significantly simplifying the fabrication process on large, thick silicon substrates, while providing comparable grating quality to our traditional potassium hydroxide (KOH) process. This technique is being used for fabricating inch size silicon grisms for several IR instruments and is planned to be used for fabricating ~ 4 inch size silicon immersion gratings later. We have obtained complete K band spectra of a total of 6 T Tauri and Ae/Be stars and their close companions at a spectral resolution of R ~ 5000 using a silicon echelle grism with a 5 mm pupil diameter at the Lick 3m telescope. These results represent the first scientific observations conducted by the high-resolution silicon grisms, and demonstrate the extremely high dispersing power of silicon- based gratings. The future of

SDSS-III: Massive Spectroscopic Surveys of the Distant Universe, the Milky Way, and Extra-Solar Planetary Systems

NASA Astrophysics Data System (ADS)

Eisenstein, Daniel J.; Weinberg, David H.; Agol, Eric; Aihara, Hiroaki; Allende Prieto, Carlos; Anderson, Scott F.; Arns, James A.; Aubourg, Éric; Bailey, Stephen; Balbinot, Eduardo; Barkhouser, Robert; Beers, Timothy C.; Berlind, Andreas A.; Bickerton, Steven J.; Bizyaev, Dmitry; Blanton, Michael R.; Bochanski, John J.; Bolton, Adam S.; Bosman, Casey T.; Bovy, Jo; Brandt, W. N.; Breslauer, Ben; Brewington, Howard J.; Brinkmann, J.; Brown, Peter J.; Brownstein, Joel R.; Burger, Dan; Busca, Nicolas G.; Campbell, Heather; Cargile, Phillip A.; Carithers, William C.; Carlberg, Joleen K.; Carr, Michael A.; Chang, Liang; Chen, Yanmei; Chiappini, Cristina; Comparat, Johan; Connolly, Natalia; Cortes, Marina; Croft, Rupert A. C.; Cunha, Katia; da Costa, Luiz N.; Davenport, James R. A.; Dawson, Kyle; De Lee, Nathan; Porto de Mello, Gustavo F.; de Simoni, Fernando; Dean, Janice; Dhital, Saurav; Ealet, Anne; Ebelke, Garrett L.; Edmondson, Edward M.; Eiting, Jacob M.; Escoffier, Stephanie; Esposito, Massimiliano; Evans, Michael L.; Fan, Xiaohui; Femenía Castellá, Bruno; Dutra Ferreira, Leticia; Fitzgerald, Greg; Fleming, Scott W.; Font-Ribera, Andreu; Ford, Eric B.; Frinchaboy, Peter M.; García Pérez, Ana Elia; Gaudi, B. Scott; Ge, Jian; Ghezzi, Luan; Gillespie, Bruce A.; Gilmore, G.; Girardi, Léo; Gott, J. Richard; Gould, Andrew; Grebel, Eva K.; Gunn, James E.; Hamilton, Jean-Christophe; Harding, Paul; Harris, David W.; Hawley, Suzanne L.; Hearty, Frederick R.; Hennawi, Joseph F.; González Hernández, Jonay I.; Ho, Shirley; Hogg, David W.; Holtzman, Jon A.; Honscheid, Klaus; Inada, Naohisa; Ivans, Inese I.; Jiang, Linhua; Jiang, Peng; Johnson, Jennifer A.; Jordan, Cathy; Jordan, Wendell P.; Kauffmann, Guinevere; Kazin, Eyal; Kirkby, David; Klaene, Mark A.; Knapp, G. R.; Kneib, Jean-Paul; Kochanek, C. S.; Koesterke, Lars; Kollmeier, Juna A.; Kron, Richard G.; Lampeitl, Hubert; Lang, Dustin; Lawler, James E.; Le Goff, Jean-Marc; Lee, Brian L.; Lee, Young Sun; Leisenring, Jarron M.; Lin, Yen-Ting; Liu, Jian; Long, Daniel C.; Loomis, Craig P.; Lucatello, Sara; Lundgren, Britt; Lupton, Robert H.; Ma, Bo; Ma, Zhibo; MacDonald, Nicholas; Mack, Claude; Mahadevan, Suvrath; Maia, Marcio A. G.; Majewski, Steven R.; Makler, Martin; Malanushenko, Elena; Malanushenko, Viktor; Mandelbaum, Rachel; Maraston, Claudia; Margala, Daniel; Maseman, Paul; Masters, Karen L.; McBride, Cameron K.; McDonald, Patrick; McGreer, Ian D.; McMahon, Richard G.; Mena Requejo, Olga; Ménard, Brice; Miralda-Escudé, Jordi; Morrison, Heather L.; Mullally, Fergal; Muna, Demitri; Murayama, Hitoshi; Myers, Adam D.; Naugle, Tracy; Neto, Angelo Fausti; Nguyen, Duy Cuong; Nichol, Robert C.; Nidever, David L.; O'Connell, Robert W.; Ogando, Ricardo L. C.; Olmstead, Matthew D.; Oravetz, Daniel J.; Padmanabhan, Nikhil; Paegert, Martin; Palanque-Delabrouille, Nathalie; Pan, Kaike; Pandey, Parul; Parejko, John K.; Pâris, Isabelle; Pellegrini, Paulo; Pepper, Joshua; Percival, Will J.; Petitjean, Patrick; Pfaffenberger, Robert; Pforr, Janine; Phleps, Stefanie; Pichon, Christophe; Pieri, Matthew M.; Prada, Francisco; Price-Whelan, Adrian M.; Raddick, M. Jordan; Ramos, Beatriz H. F.; Reid, I. Neill; Reyle, Celine; Rich, James; Richards, Gordon T.; Rieke, George H.; Rieke, Marcia J.; Rix, Hans-Walter; Robin, Annie C.; Rocha-Pinto, Helio J.; Rockosi, Constance M.; Roe, Natalie A.; Rollinde, Emmanuel; Ross, Ashley J.; Ross, Nicholas P.; Rossetto, Bruno; Sánchez, Ariel G.; Santiago, Basilio; Sayres, Conor; Schiavon, Ricardo; Schlegel, David J.; Schlesinger, Katharine J.; Schmidt, Sarah J.; Schneider, Donald P.; Sellgren, Kris; Shelden, Alaina; Sheldon, Erin; Shetrone, Matthew; Shu, Yiping; Silverman, John D.; Simmerer, Jennifer; Simmons, Audrey E.; Sivarani, Thirupathi; Skrutskie, M. F.; Slosar, Anže; Smee, Stephen; Smith, Verne V.; Snedden, Stephanie A.; Stassun, Keivan G.; Steele, Oliver; Steinmetz, Matthias; Stockett, Mark H.; Stollberg, Todd; Strauss, Michael A.; Szalay, Alexander S.; Tanaka, Masayuki; Thakar, Aniruddha R.; Thomas, Daniel; Tinker, Jeremy L.; Tofflemire, Benjamin M.; Tojeiro, Rita; Tremonti, Christy A.; Vargas Magaña, Mariana; Verde, Licia; Vogt, Nicole P.; Wake, David A.; Wan, Xiaoke; Wang, Ji; Weaver, Benjamin A.; White, Martin; White, Simon D. M.; Wilson, John C.; Wisniewski, John P.; Wood-Vasey, W. Michael; Yanny, Brian; Yasuda, Naoki; Yèche, Christophe; York, Donald G.; Young, Erick; Zasowski, Gail; Zehavi, Idit; Zhao, Bo

2011-09-01

Building on the legacy of the Sloan Digital Sky Survey (SDSS-I and II), SDSS-III is a program of four spectroscopic surveys on three scientific themes: dark energy and cosmological parameters, the history and structure of the Milky Way, and the population of giant planets around other stars. In keeping with SDSS tradition, SDSS-III will provide regular public releases of all its data, beginning with SDSS Data Release 8 (DR8), which was made public in 2011 January and includes SDSS-I and SDSS-II images and spectra reprocessed with the latest pipelines and calibrations produced for the SDSS-III investigations. This paper presents an overview of the four surveys that comprise SDSS-III. The Baryon Oscillation Spectroscopic Survey will measure redshifts of 1.5 million massive galaxies and Lyα forest spectra of 150,000 quasars, using the baryon acoustic oscillation feature of large-scale structure to obtain percent-level determinations of the distance scale and Hubble expansion rate at z < 0.7 and at z ≈ 2.5. SEGUE-2, an already completed SDSS-III survey that is the continuation of the SDSS-II Sloan Extension for Galactic Understanding and Exploration (SEGUE), measured medium-resolution (R = λ/Δλ ≈ 1800) optical spectra of 118,000 stars in a variety of target categories, probing chemical evolution, stellar kinematics and substructure, and the mass profile of the dark matter halo from the solar neighborhood to distances of 100 kpc. APOGEE, the Apache Point Observatory Galactic Evolution Experiment, will obtain high-resolution (R ≈ 30,000), high signal-to-noise ratio (S/N >= 100 per resolution element), H-band (1.51 μm < λ < 1.70 μm) spectra of 105 evolved, late-type stars, measuring separate abundances for ~15 elements per star and creating the first high-precision spectroscopic survey of all Galactic stellar populations (bulge, bar, disks, halo) with a uniform set of stellar tracers and spectral diagnostics. The Multi-object APO Radial Velocity Exoplanet

Spectroscopic mode identification of γ Doradus stars: frequencies, modes, rotation and wave leakage

NASA Astrophysics Data System (ADS)

Pollard, Karen R.; Brunsden, E.; Davie, M.; Greenwood, A.; Cottrell, P. L.

The gravity modes present in γ Doradus stars probe the deep stellar interiors and are thus of particular interest in asteroseismology. The MUSICIAN programme at the University of Canterbury has been successfully identifying frequencies and pulsation modes in many γ Doradus stars using hundreds of precise, high resolution spectroscopic observations obtained with the 1.0 m telescope and HERCULES spectrograph at the Mt John Observatory in New Zealand. In this paper we present a summary of our spectroscopic frequency and mode identifications. Of particular interest from our spectroscopic analyses are: the prevalence of (l, m) = 1, 1 modes in many γ Dor stars; the importance of stellar rotation in the interpretation of the frequency and mode identification; and finally, possible evidence of wave leakage in one of these stars.

High-resolution endoscopic ultrasound imaging and the number of needle passages are significant factors predicting high yield of endoscopic ultrasound-guided fine needle aspiration for pancreatic solid masses without an on-site cytopathologist

PubMed Central

Jeong, Seok Hoo; Yoon, Hyun Hwa; Kim, Eui Joo; Kim, Yoon Jae; Kim, Yeon Suk; Cho, Jae Hee

2017-01-01

Abstract Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is the accurate diagnostic method for pancreatic masses and its accuracy is affected by various FNA methods and EUS equipment. Therefore, we aimed to elucidate the instrumental and methodologic factors for determining the diagnostic yield of EUS-FNA for pancreatic solid masses without an on-site cytopathology evaluation. We retrospectively reviewed the medical records of 260 patients (265 pancreatic solid masses) who underwent EUS-FNA. We compared historical conventional EUS groups with high-resolution imaging devices and finally analyzed various factors affecting EUS-FNA accuracy. In total, 265 pancreatic solid masses of 260 patients were included in this study. The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of EUS-FNA for pancreatic solid masses without on-site cytopathology evaluation were 83.4%, 81.8%, 100.0%, 100.0%, and 34.3%, respectively. In comparison with conventional image group, high-resolution image group showed the increased accuracy, sensitivity and specificity of EUS-FNA (71.3% vs 92.7%, 68.9% vs 91.9%, and 100% vs 100%, respectively). On the multivariate analysis with various instrumental and methodologic factors, high-resolution imaging (P = 0.040, odds ratio = 3.28) and 3 or more needle passes (P = 0.039, odds ratio = 2.41) were important factors affecting diagnostic yield of pancreatic solid masses. High-resolution imaging and 3 or more passes were the most significant factors influencing diagnostic yield of EUS-FNA in patients with pancreatic solid masses without an on-site cytopathologist. PMID:28079803

Quantitative High-Resolution Genomic Analysis of Single Cancer Cells

PubMed Central

Hannemann, Juliane; Meyer-Staeckling, Sönke; Kemming, Dirk; Alpers, Iris; Joosse, Simon A.; Pospisil, Heike; Kurtz, Stefan; Görndt, Jennifer; Püschel, Klaus; Riethdorf, Sabine; Pantel, Klaus; Brandt, Burkhard

2011-01-01

During cancer progression, specific genomic aberrations arise that can determine the scope of the disease and can be used as predictive or prognostic markers. The detection of specific gene amplifications or deletions in single blood-borne or disseminated tumour cells that may give rise to the development of metastases is of great clinical interest but technically challenging. In this study, we present a method for quantitative high-resolution genomic analysis of single cells. Cells were isolated under permanent microscopic control followed by high-fidelity whole genome amplification and subsequent analyses by fine tiling array-CGH and qPCR. The assay was applied to single breast cancer cells to analyze the chromosomal region centred by the therapeutical relevant EGFR gene. This method allows precise quantitative analysis of copy number variations in single cell diagnostics. PMID:22140428

Quantitative high-resolution genomic analysis of single cancer cells.

PubMed

Hannemann, Juliane; Meyer-Staeckling, Sönke; Kemming, Dirk; Alpers, Iris; Joosse, Simon A; Pospisil, Heike; Kurtz, Stefan; Görndt, Jennifer; Püschel, Klaus; Riethdorf, Sabine; Pantel, Klaus; Brandt, Burkhard

2011-01-01

During cancer progression, specific genomic aberrations arise that can determine the scope of the disease and can be used as predictive or prognostic markers. The detection of specific gene amplifications or deletions in single blood-borne or disseminated tumour cells that may give rise to the development of metastases is of great clinical interest but technically challenging. In this study, we present a method for quantitative high-resolution genomic analysis of single cells. Cells were isolated under permanent microscopic control followed by high-fidelity whole genome amplification and subsequent analyses by fine tiling array-CGH and qPCR. The assay was applied to single breast cancer cells to analyze the chromosomal region centred by the therapeutical relevant EGFR gene. This method allows precise quantitative analysis of copy number variations in single cell diagnostics.

High-Resolution Autoradiography

NASA Technical Reports Server (NTRS)

Towe, George C; Gomberg, Henry J; Freemen, J W

1955-01-01

This investigation was made to adapt wet-process autoradiography to metallurgical samples to obtain high resolution of segregated radioactive elements in microstructures. Results are confined to development of the technique, which was perfected to a resolution of less than 10 microns. The radioactive samples included carbon-14 carburized iron and steel, nickel-63 electroplated samples, a powder product containing nickel-63, and tungsten-185 in N-155 alloy.

High-Resolution Spectroscopic Observations of Potassium Emissions in the Lunar Exosphere

NASA Astrophysics Data System (ADS)

Robertson, S. D.; Oliversen, R. J.; Mierkiewicz, E. J.; Kuruppuaratchi, D. C. P.; Derr, N. J.; Gallant, M. A.; McFarland, C. G.; Sarantos, M.

2017-12-01

We investigate lunar exospheric potassium D1 emissions (7698.9646 Å) using a high-resolution (R = 180,000 or 1.7 km/s) spectroscopy with our dual-etalon Fabry-Perot instrument to measure line widths and radial velocities. The Field of View (FOV) is 2 arcmin ( 224 km at the mean lunar distance of 384,400 km) positioned tangent to the sunlit limb. The FOV placements are at cardinal directions from a variety of reference craters. All observations are collected at the National Solar Observatory McMath-Pierce Telescope in Kitt Peak, Arizona. The data are from monthly observing runs in 2017 from January to June excluding February. Results are produced via a newly created automated data reduction using Python. Python was chosen as an open-source alternative to the previously used IDL and MATLAB scripts to decrease the cost of software licenses and maintenance. The potassium spectral line profiles provide a direct method to track exospheric effective temperatures and velocities. By monitoring the state of the potassium emissions over different lunar phases, solar activity, and influx of meteor streams, we can constrain physical processes of sources and sinks at the lunar surface. Mechanisms that create the exosphere include photon-stimulated desorption, thermal evaporation, meteoroid impact vaporization, and ion sputtering via solar wind. Whereas the exosphere is diminished due to the low lunar escape velocity, solar radiation pressure, and neutral gas being ionized and swept away by the interplanetary and terrestrial magnetic field. Preliminary analysis indicates an average potassium temperature of 1140 K but varying over the range of 550 K to 2000 K. Further analysis is expected for data from 2014 to 2017 to make month to month, as well as annual, comparisons of potassium emissions.

Immunocytochemistry by electron spectroscopic imaging using a homogeneously boronated peptide.

PubMed

Kessels, M M; Qualmann, B; Klobasa, F; Sierralta, W D

1996-05-01

A linear all-L-oligopeptide containing five carboranyl amino acids (corresponding to 50 boron atoms) was synthesized and specifically attached to the free thiol group of monovalent antibody fragments F(ab)'. The boronated immunoreagent was used for the direct post-embedding detection of somatotrophic hormone in ultrathin sections of porcine pituitary embedded in Spurr resin. The specific boron-labelling of secretory vesicles in somatotrophs was detected by electron spectroscopic imaging and confirmed by conventional immunogold labelling run in parallel. In comparison with immunogold, boron-labelled F(ab)'-fragments showed higher tagging frequencies, as was expected; the small uncharged immunoreagents have an elongated shape and carry the antigen-combining structure and the detection tag at opposite ends, thus allowing for high spatial resolution in electron spectroscopic imaging.

Intermediate frequency band digitized high dynamic range radiometer system for plasma diagnostics and real-time Tokamak control

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bongers, W. A.; Beveren, V. van; Westerhof, E.

2011-06-15

An intermediate frequency (IF) band digitizing radiometer system in the 100-200 GHz frequency range has been developed for Tokamak diagnostics and control, and other fields of research which require a high flexibility in frequency resolution combined with a large bandwidth and the retrieval of the full wave information of the mm-wave signals under investigation. The system is based on directly digitizing the IF band after down conversion. The enabling technology consists of a fast multi-giga sample analog to digital converter that has recently become available. Field programmable gate arrays (FPGA) are implemented to accomplish versatile real-time data analysis. A prototypemore » system has been developed and tested and its performance has been compared with conventional electron cyclotron emission (ECE) spectrometer systems. On the TEXTOR Tokamak a proof of principle shows that ECE, together with high power injected and scattered radiation, becomes amenable to measurement by this device. In particular, its capability to measure the phase of coherent signals in the spectrum offers important advantages in diagnostics and control. One case developed in detail employs the FPGA in real-time fast Fourier transform (FFT) and additional signal processing. The major benefit of such a FFT-based system is the real-time trade-off that can be made between frequency and time resolution. For ECE diagnostics this corresponds to a flexible spatial resolution in the plasma, with potential application in smart sensing of plasma instabilities such as the neoclassical tearing mode (NTM) and sawtooth instabilities. The flexible resolution would allow for the measurement of the full mode content of plasma instabilities contained within the system bandwidth.« less

Time-resolved High Spectral Resolution Observation of 2MASSW J0746425+200032AB

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Ji; Mawet, Dimitri; Prato, Lisa, E-mail: ji.wang@caltech.edu

Many brown dwarfs (BDs) exhibit photometric variability at levels from tenths to tens of percents. The photometric variability is related to magnetic activity or patchy cloud coverage, characteristic of BDs near the L–T transition. Time-resolved spectral monitoring of BDs provides diagnostics of cloud distribution and condensate properties. However, current time-resolved spectral studies of BDs are limited to low spectral resolution ( R ∼ 100) with the exception of the study of Luhman 16 AB at a resolution of 100,000 using the VLT+CRIRES. This work yielded the first map of BD surface inhomogeneity, highlighting the importance and unique contribution of highmore » spectral resolution observations. Here, we report on the time-resolved high spectral resolution observations of a nearby BD binary, 2MASSW J0746425+200032AB. We find no coherent spectral variability that is modulated with rotation. Based on simulations, we conclude that the coverage of a single spot on 2MASSW J0746425+200032AB is smaller than 1% or 6.25% if spot contrast is 50% or 80% of its surrounding flux, respectively. Future high spectral resolution observations aided by adaptive optics systems can put tighter constraints on the spectral variability of 2MASSW J0746425+200032AB and other nearby BDs.« less

Application of spatially resolved high resolution crystal spectrometry to inertial confinement fusion plasmas.

PubMed

Hill, K W; Bitter, M; Delgado-Aparacio, L; Pablant, N A; Beiersdorfer, P; Schneider, M; Widmann, K; Sanchez del Rio, M; Zhang, L

2012-10-01

High resolution (λ∕Δλ ∼ 10 000) 1D imaging x-ray spectroscopy using a spherically bent crystal and a 2D hybrid pixel array detector is used world wide for Doppler measurements of ion-temperature and plasma flow-velocity profiles in magnetic confinement fusion plasmas. Meter sized plasmas are diagnosed with cm spatial resolution and 10 ms time resolution. This concept can also be used as a diagnostic of small sources, such as inertial confinement fusion plasmas and targets on x-ray light source beam lines, with spatial resolution of micrometers, as demonstrated by laboratory experiments using a 250-μm (55)Fe source, and by ray-tracing calculations. Throughput calculations agree with measurements, and predict detector counts in the range 10(-8)-10(-6) times source x-rays, depending on crystal reflectivity and spectrometer geometry. Results of the lab demonstrations, application of the technique to the National Ignition Facility (NIF), and predictions of performance on NIF will be presented.

Organic electronics for high-resolution electrocorticography of the human brain.

PubMed

Khodagholy, Dion; Gelinas, Jennifer N; Zhao, Zifang; Yeh, Malcolm; Long, Michael; Greenlee, Jeremy D; Doyle, Werner; Devinsky, Orrin; Buzsáki, György

2016-11-01

Localizing neuronal patterns that generate pathological brain signals may assist with tissue resection and intervention strategies in patients with neurological diseases. Precise localization requires high spatiotemporal recording from populations of neurons while minimizing invasiveness and adverse events. We describe a large-scale, high-density, organic material-based, conformable neural interface device ("NeuroGrid") capable of simultaneously recording local field potentials (LFPs) and action potentials from the cortical surface. We demonstrate the feasibility and safety of intraoperative recording with NeuroGrids in anesthetized and awake subjects. Highly localized and propagating physiological and pathological LFP patterns were recorded, and correlated neural firing provided evidence about their local generation. Application of NeuroGrids to brain disorders, such as epilepsy, may improve diagnostic precision and therapeutic outcomes while reducing complications associated with invasive electrodes conventionally used to acquire high-resolution and spiking data.

Diagnostic value of high-resolution B-mode and power-mode sonography in the follow-up of thyroid cancer.

PubMed

Görges, Rainer; Eising, E G; Fotescu, D; Renzing-Köhler, K; Frilling, A; Schmid, K W; Bockisch, A; Dirsch, O

2003-02-01

Ultrasonography is an established diagnostic modality in the follow-up of thyroid cancer. Color flow Doppler has been proposed by some authors as an additional tool for differentiating benign from malignant cervical lesions in various types of head and neck cancer. Over the last few years, a new generation of high-resolution ultrasound platforms with the "power-mode" feature has become available, that also enables the imaging of small vessel blood flow. The objective of our study was to find ways of optimizing the differentiation of benign and malignant cervical tumors in thyroid cancer follow-up by means of sonography. Hundred and twelve cervical lesions in 90 patients with thyroid cancer were evaluated by high-end ultrasonography (Sonoline Elegra, Siemens) using a small-part transducer (7.5 L 40, Siemens). B-mode sonography was performed at a frequency of 8 MHz. The Solbiati index (SI= ratio of largest to smallest diameter), configuration, echogenicity, intranodular structures, and margins were assessed. Perinodular and intranodular blood flow was evaluated by color flow Doppler (PRF 1250 Hz for conventional color flow Doppler, 868 Hz for power-mode Doppler). Possible malignancy was validated by histology, cytology, scintigraphy, and follow-up. Thirty five lesions were benign (diameter 0.4-3.0 cm) and 77 were malignant (0.4-5.4 cm). The patients were randomized into a test group and a learning group to determine the diagnostic value of various ultrasound criteria by means of statistical analysis. In the learning group, decision rules based on the dichotomized criteria were developed using a logistic regression model. Sensitivity and specificity of these decision rules were then evaluated in the test group. The presence of an echocomplex pattern or irregular hyperechoic small intranodular structures (criterion A) and the presence of an irregular diffuse intranodular blood flow (criterion B) are the best indicators of malignancy, whereas an SI >2 is highly

What Do High-Resolution EIT Waves Tell Us About CMEs?

NASA Technical Reports Server (NTRS)

Thompson, Barbara

2010-01-01

Although many studies have demonstrated that some coronal waves are not generated by corona) mass ejections, we have learned a great deal about the ability of corona) mass ejections to drive large-scale corona) waves, also called "EIT waves." We present new results based on EIT wave amplitude, timing, speed, and direction of propagation, with respect to their correlation with CME-related dimmings, speeds, locations and widths. Furthermore, we demonstrate the ability to correlate different aspects of EIT waves with some of the observed structure of CMEs observed in coronagraph data. Finally, we expand on the discussion of the types of wave modes that can be generated by a corona) mass ejection, and how these observations can serve as a diagnostic of the type of impulse a CME can deliver to the surrounding corona. These diagnostics are obtained by examining the motion of individual field lines, requiring high-resolution observations like those provided by TRACE and SDO/AIA.

A NEARLY VOLUME-COMPLETE SPECTROSCOPIC SURVEY OF THE CLOSESTMID-TO-LATE M DWARFS

NASA Astrophysics Data System (ADS)

Winters, Jennifer; Irwin, Jonathan; Newton, Elisabeth; Charbonneau, David; Latham, David W.; Mink, Jessica; Esquerdo, Gil; Berlind, Perry; Calkins, Mike

2018-01-01

Recent results from Kepler estimate that M dwarfs harbor 2.5 planets per star. Yet, we will understand our exoplanet discoveries only as well as we understand their host stars, and much remains unknown about our low-mass stellar neighbors, such as their kinematics, ages, and multiplicity. A nearly volume-complete sample of M dwarfs lies within 15 pc of the Sun, and it is only for planets orbiting these nearest and smallest stars that thorough follow-up work for characterization will be possible. Unfortunately, more than half of this sample have only low-resolution (R < 19,000) spectroscopic measurements available from the literature, while ten percent have no published spectrum at all.We have undertaken a multi-epoch, high-resolution (R ~ 44,000) spectroscopic survey of the mid-to-late M dwarfs that lie within 15 pc via acurate trigonometric parallaxes. Observations with the Tillinghast Reflector Echelle Spectrograph (TRES) on the 1.5m telescope at the Fred Lawrence Whipple Observatory (FLWO) on Mt. Hopkins, AZ, are currently underway. We will shortly begin the southern part of this survey with CHIRON at the Cerro Tololo Inter-American Observatory / Small and Moderate Aperture Research Telescope System (CTIO/SMARTS) 1.5m. We present here results from year one of our TRES survey. We have measured radial velocities, rotational broadening, and H-alpha equivalent widths for 305 mid-to-late M dwarfs. We have discovered five new spectroscopic binaries, one of which is a rare M dwarf - (likely) brown dwarf binary within 10 pc, for which we have determined the orbit.Our survey more than doubles the number of mid-M dwarfs within 15 pc with complete high-resolution spectroscopic and trigonometric characterization. We hope to provide a legacy dataset for the use of future generations of astronomers.This work is being supported by grants from the National Science Foundation and the John Templeton Foundation.

High-resolution UV-visible spectroscopy of lunar red spots

NASA Technical Reports Server (NTRS)

Bruno, B. C.; Lucey, P. G.; Hawke, B. R.

1991-01-01

A spectral reflectance study of selected lunar 'red spots', highland areas characterized by an absorption in the ultraviolet relative to the visible was conducted. Some red spots were suggested to be the sites of ancient highland volcanism. High-resolution spectral data of eight red spots on the western portion of the moon over the wavelength region 0.39-0.82 micron were obtained. Much spectral variation among these red spots in the magnitude as well as the wavelength position of the ultraviolet absorption were found. Spectral structure at visible and near-infrared wavelength were also identified. These spectral differences indicate that red spots do not have a single mineralogical composition, which in turn suggests that red spots may have multiple origins. Additional imaging spectroscopic observations were taken of the Herigonius red spot, a morphologically complex region northeast of Mare Humorum. These data reveal significant spectral differences among the various morphological units within the Herigonius red spot. Although some of these are likely due to the effects of the maturation process, others appear to reflect differences in mineral abundances and composition.

Chromospheric activity on late-type star DM UMa using high-resolution spectroscopic observations

NASA Astrophysics Data System (ADS)

Zhang, LiYun; Pi, QingFeng; Han, Xianming L.; Chang, Liang; Wang, Daimei

2016-06-01

We present new 14 high-resolution echelle spectra to discuss the level of chromospheric activity of DM UMa in {He I} D3, {Na I} D1, D2, Hα, and {Ca II} infrared triplet lines (IRT). It is the first time to discover the emissions above the continuum in the {He I} D3 lines on 2015 February 9 and 10. The emission on February 9 is the strongest one ever detected for DM UMa. We analysed these chromospheric active indicators by employing the spectral subtraction technique. The subtracted spectra reveal weak emissions in the {Na I} D1, D2 lines, strong emission in the Hα line, and clear excess emissions in the {Ca II} IRT lines. Our values for the EW8542/EW8498 ratio are on the low side, in the range of 1.0-1.7. There are also clear phase variations of the level of chromospheric activity in equivalent width (EW) light curves in these chromospheric active lines (especially the Hα line). These phenomena might be explained by flare events or rotational modulations of the level of chromospheric activity.

A high-resolution photoelectron imaging and theoretical study of CP- and C2P-

NASA Astrophysics Data System (ADS)

Czekner, Joseph; Cheung, Ling Fung; Johnson, Eric L.; Fortenberry, Ryan C.; Wang, Lai-Sheng

2018-01-01

The discovery of interstellar anions has been a milestone in astrochemistry. In the search for new interstellar anions, CP- and C2P- are viable candidates since their corresponding neutrals have already been detected astronomically. However, scarce data exist for these negatively charged species. Here we report the electron affinities of CP and C2P along with the vibrational frequencies of their anions using high-resolution photoelectron imaging. These results along with previous spectroscopic data of the neutral species are used further to benchmark very accurate quartic force field quantum chemical methods that are applied to CP, CP-, C2P, and two electronic states of C2P-. The predicted electron affinities, vibrational frequencies, and rotational constants are in excellent agreement with the experimental data. The electron affinities of CP (2.8508 ± 0.0007 eV) and C2P (2.6328 ± 0.0006 eV) are measured accurately and found to be quite high, suggesting that the CP- and C2P- anions are thermodynamically stable and possibly observable. The current study suggests that the combination of high-resolution photoelectron imaging and quantum chemistry can be used to determine accurate molecular constants for exotic radical species of astronomical interest.

A high-resolution photoelectron imaging and theoretical study of CP- and C2P.

PubMed

Czekner, Joseph; Cheung, Ling Fung; Johnson, Eric L; Fortenberry, Ryan C; Wang, Lai-Sheng

2018-01-28

The discovery of interstellar anions has been a milestone in astrochemistry. In the search for new interstellar anions, CP - and C 2 P - are viable candidates since their corresponding neutrals have already been detected astronomically. However, scarce data exist for these negatively charged species. Here we report the electron affinities of CP and C 2 P along with the vibrational frequencies of their anions using high-resolution photoelectron imaging. These results along with previous spectroscopic data of the neutral species are used further to benchmark very accurate quartic force field quantum chemical methods that are applied to CP, CP - , C 2 P, and two electronic states of C 2 P - . The predicted electron affinities, vibrational frequencies, and rotational constants are in excellent agreement with the experimental data. The electron affinities of CP (2.8508 ± 0.0007 eV) and C 2 P (2.6328 ± 0.0006 eV) are measured accurately and found to be quite high, suggesting that the CP - and C 2 P - anions are thermodynamically stable and possibly observable. The current study suggests that the combination of high-resolution photoelectron imaging and quantum chemistry can be used to determine accurate molecular constants for exotic radical species of astronomical interest.

Retrieval of high-spectral-resolution lidar for atmospheric aerosol optical properties profiling

NASA Astrophysics Data System (ADS)

Liu, Dong; Luo, Jing; Yang, Yongying; Cheng, Zhongtao; Zhang, Yupeng; Zhou, Yudi; Duan, Lulin; Su, Lin

2015-10-01

High-spectral-resolution lidars (HSRLs) are increasingly being developed for atmospheric aerosol remote sensing applications due to the straightforward and independent retrieval of aerosol optical properties without reliance on assumptions about lidar ratio. In HSRL technique, spectral discrimination between scattering from molecules and aerosol particles is one of the most critical processes, which needs to be accomplished by means of a narrowband spectroscopic filter. To ensure a high retrieval accuracy of an HSRL system, the high-quality design of its spectral discrimination filter should be made. This paper reviews the available algorithms that were proposed for HSRLs and makes a general accuracy analysis of the HSRL technique focused on the spectral discrimination, in order to provide heuristic guidelines for the reasonable design of the spectral discrimination filter. We introduce a theoretical model for retrieval error evaluation of an HSRL instrument with general three-channel configuration. Monte Carlo (MC) simulations are performed to validate the correctness of the theoretical model. Results from both the model and MC simulations agree very well, and they illustrate one important, although not well realized fact: a large molecular transmittance and a large spectral discrimination ratio (SDR, i.e., ratio of the molecular transmittance to the aerosol transmittance) are beneficial t o promote the retrieval accuracy. The application of the conclusions obtained in this paper in the designing of a new type of spectroscopic filter, that is, the field-widened Michelson interferometer, is illustrated in detail. These works are with certain universality and expected to be useful guidelines for HSRL community, especially when choosing or designing the spectral discrimination filter.

Monolithic echo-less photoconductive switches as a high-resolution detector for terahertz time-domain spectroscopy

NASA Astrophysics Data System (ADS)

Maussang, K.; Palomo, J.; Manceau, J.-M.; Colombelli, R.; Sagnes, I.; Li, L. H.; Linfield, E. H.; Davies, A. G.; Mangeney, J.; Tignon, J.; Dhillon, S. S.

2017-04-01

Interdigitated photoconductive (iPC) switches are powerful and convenient devices for time-resolved spectroscopy, with the ability to operate both as sources and detectors of terahertz (THz) frequency pulses. However, reflection of the emitted or detected radiation within the device substrate itself can lead to echoes that inherently limit the spectroscopic resolution achievable for their use in time-domain spectroscopy (TDS) systems. In this work, we demonstrate a design of low-temperature-grown-GaAs (LT-GaAs) iPC switches for THz pulse detection that suppresses such unwanted echoes. This is realized through the growth of a buried multilayer LT-GaAs structure that retains its ultrafast properties, which, after wafer bonding to a metal-coated host substrate, results in an iPC switch with a metal plane buried at a subwavelength depth below the LT-GaAs surface. Using this device as a detector, and coupling it to an echo-less iPC source, enables echo-free THz-TDS and high-resolution spectroscopy, with a resolution limited only by the temporal length of the measurement governed by the mechanical delay line used. As a proof-of-principle, the 212-221 and the 101-212 rotational lines of water vapor have been spectrally resolved, demonstrating a spectral resolution below 10 GHz.

Optimization and application of cooled avalanche photodiodes for spectroscopic fluctuation measurements with ultra-fast charge exchange recombination spectroscopy

DOE PAGES

Truong, D. D.; Fonck, R. J.; McKee, G. R.

2016-09-23

The Ultra Fast Charge Exchange Recombination Spectroscopy (UF-CHERS) diagnostic is a highly specialized spectroscopic instrument with 2 spatial channels consisting of 8 spectral channels each and a resolution of ~0.25 nm deployed at DIII-D to measure turbulent ion temperature fluctuations. Charge exchange emissions are obtained between 528-530 nm with 1 μs time resolution to study plasma instabilities. A primary challenge of extracting fluctuation measurements from raw UF-CHERS signals is photon and electronic noise. In order to reduce dark current, the Avalanche Photodiode (APD) detectors are thermoelectrically cooled. State-of-the-art components are used for the signal amplifiers and conditioners to minimize electronicmore » noise. Due to the low incident photon power (≤ 1 nW), APDs with a gain of up to 300 are used to optimize the signal to noise ratio. Maximizing the APDs’ gain while minimizing the excess noise factor (ENF) is essential since the total noise of the diagnostic sets a floor for the minimum level of detectable broadband fluctuations. The APDs’ gain should be high enough that photon noise dominates electronic noise, but not excessive so that the ENF overwhelms plasma fluctuations. A new generation of cooled APDs and optimized preamplifiers exhibits significantly enhanced signal-to-noise compared to a previous generation. Experiments at DIII-D have allowed for characterization and optimization of the ENF vs. gain. Here, a gain of ~100 at 1700 V is found to be near optimal for most plasma conditions. Ion temperature and toroidal velocity fluctuations due to the Edge Harmonic Oscillation (EHO) in Quiescent H-mode (QH) plasmas are presented to demonstrate UF-CHERS’ capabilities.« less

Spatial resolution test of a beam diagnostic system for DESIREE

NASA Astrophysics Data System (ADS)

Das, Susanta; Kallberg, A.

2010-11-01

A diagnostic system based on the observation of low energy ( ˜ 10 eV) secondary electrons (SE) produced by a beam, striking a metallic foil has been built to monitor and to cover the wide range of beam intensities and energies for Double ElectroStatic Ion Ring ExpEriment [1,2].The system consists of a Faraday cup to measure the beam current, a collimator with circular apertures of different diameters to measure the spatial resolution of the system, a beam profile monitoring system (BPMS), and a control unit. The BPMS, in turn, consists of an aluminim (Al) foil, a grid placed in front of the Al foil to accelerate the SE, position sensitive MCP, fluorescent screen, and a CCD camera to capture the images. The collimator contains a set of circular holes of different diameters and separations (d) between them. The collimator cuts out from the beam areas equal to the holes with separation d mm between the beams centers and creates well separated (distinguishable) narrow beams of approximately same intensity close to each other. A 10 keV proton beam was used. The spatial resolution of the system was tested for different Al plate and MCP voltages and resolution of better than 2 mm was achieved. Ref.: 1. K. Kruglov {et al}., NIM A 441 (2000) 595; 701 (2002) 193c, 2. MSL and Atomic Physics, Stockholm Univ.(www.msl.se, http://www.atom.physto.se/Cederquist/desiree/web/hc.html).

A targeted illumination optical fiber probe for high resolution fluorescence imaging and optical switching

NASA Astrophysics Data System (ADS)

Shinde, Anant; Perinchery, Sandeep Menon; Murukeshan, Vadakke Matham

2017-04-01

An optical imaging probe with targeted multispectral and spatiotemporal illumination features has applications in many diagnostic biomedical studies. However, these systems are mostly adapted in conventional microscopes, limiting their use for in vitro applications. We present a variable resolution imaging probe using a digital micromirror device (DMD) with an achievable maximum lateral resolution of 2.7 μm and an axial resolution of 5.5 μm, along with precise shape selective targeted illumination ability. We have demonstrated switching of different wavelengths to image multiple regions in the field of view. Moreover, the targeted illumination feature allows enhanced image contrast by time averaged imaging of selected regions with different optical exposure. The region specific multidirectional scanning feature of this probe has facilitated high speed targeted confocal imaging.

Spectroscopic Terahertz Imaging at Room Temperature Employing Microbolometer Terahertz Sensors and Its Application to the Study of Carcinoma Tissues

PubMed Central

Kašalynas, Irmantas; Venckevičius, Rimvydas; Minkevičius, Linas; Sešek, Aleksander; Wahaia, Faustino; Tamošiūnas, Vincas; Voisiat, Bogdan; Seliuta, Dalius; Valušis, Gintaras; Švigelj, Andrej; Trontelj, Janez

2016-01-01

A terahertz (THz) imaging system based on narrow band microbolometer sensors (NBMS) and a novel diffractive lens was developed for spectroscopic microscopy applications. The frequency response characteristics of the THz antenna-coupled NBMS were determined employing Fourier transform spectroscopy. The NBMS was found to be a very sensitive frequency selective sensor which was used to develop a compact all-electronic system for multispectral THz measurements. This system was successfully applied for principal components analysis of optically opaque packed samples. A thin diffractive lens with a numerical aperture of 0.62 was proposed for the reduction of system dimensions. The THz imaging system enhanced with novel optics was used to image for the first time non-neoplastic and neoplastic human colon tissues with close to wavelength-limited spatial resolution at 584 GHz frequency. The results demonstrated the new potential of compact RT THz imaging systems in the fields of spectroscopic analysis of materials and medical diagnostics. PMID:27023551

High-resolution spectroscopy of extremely metal-poor stars from SDSS/Segue. II. Binary fraction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aoki, Wako; Suda, Takuma; Beers, Timothy C.

2015-02-01

The fraction of binary systems in various stellar populations of the Galaxy and the distribution of their orbital parameters are important but not well-determined factors in studies of star formation, stellar evolution, and Galactic chemical evolution. While observational studies have been carried out for a large sample of nearby stars, including some metal-poor Population II stars, almost no constraints on the binary nature for extremely metal-poor (EMP; [Fe/H] <−3.0) stars have yet been obtained. Here we investigate the fraction of double-lined spectroscopic binaries and carbon-enhanced metal-poor (CEMP) stars, many of which could have formed as pairs of low-mass and intermediate-massmore » stars, to estimate the lower limit of the fraction of binary systems having short periods. The estimate is based on a sample of very metal-poor stars selected from the Sloan Digital Sky Survey and observed at high spectral resolution in a previous study by Aoki et al. That survey reported 3 double-lined spectroscopic binaries and 11 CEMP stars, which we consider along with a sample of EMP stars from the literature compiled in the SAGA database. We have conducted measurements of the velocity components for stacked absorption features of different spectral lines for each double-lined spectroscopic binary. Our estimate indicates that the fraction of binary stars having orbital periods shorter than 1000 days is at least 10%, and possibly as high as 20% if the majority of CEMP stars are formed in such short-period binaries. This result suggests that the period distribution of EMP binary systems is biased toward short periods, unless the binary fraction of low-mass EMP stars is significantly higher than that of other nearby stars.« less

High resolution digital delay timer

DOEpatents

Martin, Albert D.

1988-01-01

Method and apparatus are provided for generating an output pulse following a trigger pulse at a time delay interval preset with a resolution which is high relative to a low resolution available from supplied clock pulses. A first lumped constant delay (20) provides a first output signal (24) at predetermined interpolation intervals corresponding to the desired high resolution time interval. Latching circuits (26, 28) latch the high resolution data (24) to form a first synchronizing data set (60). A selected time interval has been preset to internal counters (142, 146, 154) and corrected for circuit propagation delay times having the same order of magnitude as the desired high resolution. Internal system clock pulses (32, 34) count down the counters to generate an internal pulse delayed by an interval which is functionally related to the preset time interval. A second LCD (184) corrects the internal signal with the high resolution time delay. A second internal pulse is then applied to a third LCD (74) to generate a second set of synchronizing data (76) which is complementary with the first set of synchronizing data (60) for presentation to logic circuits (64). The logic circuits (64) further delay the internal output signal (72) to obtain a proper phase relationship of an output signal (80) with the internal pulses (32, 34). The final delayed output signal (80) thereafter enables the output pulse generator (82) to produce the desired output pulse (84) at the preset time delay interval following input of the trigger pulse (10, 12).

Highly efficient chiral resolution of DL-arginine by cocrystal formation followed by recrystallization under preferential-enrichment conditions.

PubMed

Iwama, Sekai; Kuyama, Kazunori; Mori, Yuko; Manoj, Kochunnoonny; Gonnade, Rajesh G; Suzuki, Katsuaki; Hughes, Colan E; Williams, P Andrew; Harris, Kenneth D M; Veesler, Stéphane; Takahashi, Hiroki; Tsue, Hirohito; Tamura, Rui

2014-08-11

An excellent chiral symmetry-breaking spontaneous enantiomeric resolution phenomenon, denoted preferential enrichment, was observed on recrystallization of the 1:1 cocrystal of dl-arginine and fumaric acid, which is classified as a racemic compound crystal with a high eutectic ee value (>95 %), under non-equilibrium crystallization conditions. On the basis of temperature-controlled video microscopy and in situ time-resolved solid-state (13) C NMR spectroscopic studies on the crystallization process, a new mechanism of phase transition that can induce preferential enrichment is proposed. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

High-resolution, low-delay, and error-resilient medical ultrasound video communication using H.264/AVC over mobile WiMAX networks.

PubMed

Panayides, Andreas; Antoniou, Zinonas C; Mylonas, Yiannos; Pattichis, Marios S; Pitsillides, Andreas; Pattichis, Constantinos S

2013-05-01

In this study, we describe an effective video communication framework for the wireless transmission of H.264/AVC medical ultrasound video over mobile WiMAX networks. Medical ultrasound video is encoded using diagnostically-driven, error resilient encoding, where quantization levels are varied as a function of the diagnostic significance of each image region. We demonstrate how our proposed system allows for the transmission of high-resolution clinical video that is encoded at the clinical acquisition resolution and can then be decoded with low-delay. To validate performance, we perform OPNET simulations of mobile WiMAX Medium Access Control (MAC) and Physical (PHY) layers characteristics that include service prioritization classes, different modulation and coding schemes, fading channels conditions, and mobility. We encode the medical ultrasound videos at the 4CIF (704 × 576) resolution that can accommodate clinical acquisition that is typically performed at lower resolutions. Video quality assessment is based on both clinical (subjective) and objective evaluations.

Implementation of a high-resolution workstation for primary diagnosis of projection radiography images

NASA Astrophysics Data System (ADS)

Good, Walter F.; Herron, John M.; Maitz, Glenn S.; Gur, David; Miller, Stephen L.; Straub, William H.; Fuhrman, Carl R.

1990-08-01

We designed and implemented a high-resolution video workstation as the central hardware component in a comprehensive multi-project program comparing the use of digital and film modalities. The workstation utilizes a 1.8 GByte real-time disk (RCI) capable of storing 400 full-resolution images and two Tektronix (GMA251) display controllers with 19" monitors (GMA2O2). The display is configured in a portrait format with a resolution of 1536 x 2048 x 8 bit, and operates at 75 Hz in a noninterlaced mode. Transmission of data through a 12 to 8 bit lookup table into the display controllers occurs at 20 MBytes/second (.35 seconds per image). The workstation allows easy use of brightness (level) and contrast (window) to be manipulated with a trackball, and various processing options can be selected using push buttons. Display of any of the 400 images is also performed at 20MBytes/sec (.35 sec/image). A separate text display provides for the automatic display of patient history data and for a scoring form through which readers can interact with the system by means of a computer mouse. In addition, the workstation provides for the randomization of cases and for the immediate entry of diagnostic responses into a master database. Over the past year this workstation has been used for over 10,000 readings in diagnostic studies related to 1) image resolution; 2) film vs. soft display; 3) incorporation of patient history data into the reading process; and 4) usefulness of image processing.

Marvel Analysis of the Measured High-resolution Rovibronic Spectra of TiO

NASA Astrophysics Data System (ADS)

McKemmish, Laura K.; Masseron, Thomas; Sheppard, Samuel; Sandeman, Elizabeth; Schofield, Zak; Furtenbacher, Tibor; Császár, Attila G.; Tennyson, Jonathan; Sousa-Silva, Clara

2017-02-01

Accurate, experimental rovibronic energy levels, with associated labels and uncertainties, are reported for 11 low-lying electronic states of the diatomic {}48{{Ti}}16{{O}} molecule, determined using the Marvel (Measured Active Rotational-Vibrational Energy Levels) algorithm. All levels are based on lines corresponding to critically reviewed and validated high-resolution experimental spectra taken from 24 literature sources. The transition data are in the 2-22,160 cm-1 region. Out of the 49,679 measured transitions, 43,885 are triplet-triplet, 5710 are singlet-singlet, and 84 are triplet-singlet transitions. A careful analysis of the resulting experimental spectroscopic network (SN) allows 48,590 transitions to be validated. The transitions determine 93 vibrational band origins of {}48{{Ti}}16{{O}}, including 71 triplet and 22 singlet ones. There are 276 (73) triplet-triplet (singlet-singlet) band-heads derived from Marvel experimental energies, 123(38) of which have never been assigned in low- or high-resolution experiments. The highest J value, where J stands for the total angular momentum, for which an energy level is validated is 163. The number of experimentally derived triplet and singlet {}48{{Ti}}16{{O}} rovibrational energy levels is 8682 and 1882, respectively. The lists of validated lines and levels for {}48{{Ti}}16{{O}} are deposited in the supporting information to this paper.

High-resolution PET [Positron Emission Tomography] for Medical Science Studies

DOE R&D Accomplishments Database

Budinger, T. F.; Derenzo, S. E.; Huesman, R. H.; Jagust, W. J.; Valk, P. E.

1989-09-01

One of the unexpected fruits of basic physics research and the computer revolution is the noninvasive imaging power available to today's physician. Technologies that were strictly the province of research scientists only a decade or two ago now serve as the foundations for such standard diagnostic tools as x-ray computer tomography (CT), magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), ultrasound, single photon emission computed tomography (SPECT), and positron emission tomography (PET). Furthermore, prompted by the needs of both the practicing physician and the clinical researcher, efforts to improve these technologies continue. This booklet endeavors to describe the advantages of achieving high resolution in PET imaging.

High-Resolution Spectroscopic Observations of Potassium Emissions in the Lunar Exosphere

NASA Astrophysics Data System (ADS)

Robertson, Sarena D.; Oliversen, Ronald J.; Mierkiewicz, Edwin J.; Kuruppuaratchi, Dona Chathuni P.; Derr, Nicholas James; Gallant, Margaret A.; McFarland, Christina G.; Sarantos, Menelaos

2018-01-01

We investigate lunar exospheric potassium D1 emissions (7698.9646 Å) using high-resolution (R = 180,000 or 1.7 km/s) spectroscopy with our dual-etalon Fabry-Perot instrument to measure line widths and radial velocities. The Field of View (FOV) is 2 arcmins (~224 km at the mean lunar distance of 384,400 km) positioned tangent to the sunlit limb. The FOV placements are at cardinal directions from a variety of reference craters. All observations are collected at the National Solar Observatory McMath-Pierce Telescope in Kitt Peak, Arizona. The data are from several observations from 2014 through 2017 at various times of the year. Results are produced via a newly created automated data reduction using Python. Python was chosen as an open-source alternative to the previously used IDL and MATLAB scripts to decrease the cost of software licenses and maintenance. The potassium spectral line profiles provide a direct method to track exospheric effective temperatures and velocities. By monitoring the state of the potassium emissions over different lunar phases, solar activity, and the influx of meteor streams, we can constrain physical processes of sources and sinks at the lunar surface. Mechanisms that create the exosphere include photon-stimulated desorption, thermal evaporation, meteoroid impact vaporization, and ion sputtering via solar wind. In contrast, the exosphere is diminished due to the low lunar escape velocity, solar radiation pressure, and neutral gas being ionized and swept away by the interplanetary and terrestrial magnetic field. Preliminary analysis of 2017 data (January through June, excluding February) indicates an average potassium temperature of 1140 K but varying over the range of 550 K to 2000 K. Preliminary results from 2014 data depict a similar range of temperatures to that of 2017. Further analysis is expected for additional data from 2014 to later observations in 2017 that were not included in the initial set of models.

High-resolution rapid diagnostic imaging of whole prostate biopsies using video-rate fluorescence structured illumination microscopy

PubMed Central

Wang, Mei; Kimbrell, Hillary Z.; Sholl, Andrew B.; Tulman, David B.; Elfer, Katherine N.; Schlichenmeyer, Tyler C.; Lee, Benjamin R.; Lacey, Michelle; Brown, J. Quincy

2015-01-01

Rapid assessment of prostate core biopsy pathology at the point-of-procedure could provide benefit in a variety of clinical situations. Even with advanced trans-rectal ultrasound guidance and saturation biopsy protocols, prostate cancer can be missed in up to half of all initial biopsy procedures. In addition, collection of tumor specimens for downstream histological, molecular, and genetic analysis is hindered by low tumor yield due to inability to identify prostate cancer grossly. However, current point-of-procedure pathology protocols such as frozen section analysis (FSA) are destructive, and too time- and labor-intensive to be practical or economical. Ex vivo microscopy of the excised specimens, stained with fast-acting fluorescent histology dyes, could be an attractive non-destructive alternative to FSA. In this work, we report the first demonstration of video-rate structured illumination microscopy (VR-SIM) for rapid high-resolution diagnostic imaging of prostate biopsies in realistic point-of-procedure timeframes. Large mosaic images of prostate biopsies stained with acridine orange are rendered in seconds, and contain excellent contrast and detail, exhibiting close correlation with corresponding H&E histology. A clinically-relevant review of VR-SIM images of 34 unfixed and uncut prostate core biopsies by two independent pathologists resulted in an area under the ROC curve (AUC) of 0.82–0.88, with a sensitivity ranging from 63–88% and a specificity ranging from 78–89%. When biopsies contained more than 5% tumor content, the sensitivity improved to 75–92%. The image quality, speed, minimal complexity, and ease of use of VR-SIM could prove to be features in favor of adoption as an alternative to destructive pathology at the point-of-procedure. PMID:26282168

Extracting the redox orbitals in Li battery materials with high-resolution x-ray compton scattering spectroscopy.

PubMed

Suzuki, K; Barbiellini, B; Orikasa, Y; Go, N; Sakurai, H; Kaprzyk, S; Itou, M; Yamamoto, K; Uchimoto, Y; Wang, Yung Jui; Hafiz, H; Bansil, A; Sakurai, Y

2015-02-27

We present an incisive spectroscopic technique for directly probing redox orbitals based on bulk electron momentum density measurements via high-resolution x-ray Compton scattering. Application of our method to spinel Li_{x}Mn_{2}O_{4}, a lithium ion battery cathode material, is discussed. The orbital involved in the lithium insertion and extraction process is shown to mainly be the oxygen 2p orbital. Moreover, the manganese 3d states are shown to experience spatial delocalization involving 0.16±0.05 electrons per Mn site during the battery operation. Our analysis provides a clear understanding of the fundamental redox process involved in the working of a lithium ion battery.

CHISL: the combined high-resolution and imaging spectrograph for the LUVOIR surveyor

NASA Astrophysics Data System (ADS)

France, Kevin; Fleming, Brian; Hoadley, Keri

2016-10-01

NASA is currently carrying out science and technical studies to identify its next astronomy flagship mission, slated to begin development in the 2020s. It has become clear that a Large Ultraviolet/Optical/IR (LUVOIR) surveyor mission (d≈12 m, Δλ≈1000 Å, 2 μm spectroscopic bandpass) can carry out the largest number of NASA's exoplanet and astrophysics science goals over the coming decades. The science grasp of an LUVOIR surveyor is broad, ranging from the direct detection of potential biomarkers on rocky planets to the flow of matter into and out of galaxies and the history of star-formation across cosmic time. There are technical challenges for several aspects of the LUVOIR surveyor concept, including component level technology readiness maturation and science instrument concepts for a broadly capable ultraviolet spectrograph. We present the scientific motivation for, and a preliminary design of, a multiplexed ultraviolet spectrograph to support both the exoplanet and astrophysics goals of the LUVOIR surveyor mission concept, the combined high-resolution and imaging spectrograph for the LUVOIR surveyor (CHISL). CHISL includes a high-resolution (R≈120,000 1000 to 1700 Å) point-source spectroscopy channel and a medium-resolution (R≥14,000 from 1000 to 2000 Å in a single observation and R˜24,000 to 35,000 in multiple grating settings) imaging spectroscopy channel. CHISL addresses topics ranging from characterizing the composition and structure of planet-forming disks to the feedback of matter between galaxies and the intergalactic medium. We present the CHISL concept, a small sample of representative science cases, and the primary technological hurdles. Technical challenges include high-efficiency ultraviolet coatings and high-quantum efficiency, large-format, photon counting detectors. We are actively engaged in laboratory and flight characterization efforts for all of these enabling technologies as components on sounding rocket payloads under

a Vacuum Ultraviolet Study of the Alcator C Tokamak Plasma Using a High Resolution, One-Dimensional Photon Counting Detector.

NASA Astrophysics Data System (ADS)

Benjamin, Russell D.

A photon counting detector based on an image intensified photodiode array was developed to meet the needs of one particular area of spectroscopic study, the determination of the kinetic temperature of impurity species. The image intensifier incorporates 3 high strip current ( ~300 muA) microchannel plates in a 'Z' configuration to achieve the gain required for the detection of single photon events. The design, construction, and laboratory testing of this system to determine its suitability for fusion plasma diagnostics is described, in particular, the ability to measure emission line profiles in order to determine the kinetic temperature of the emitting species. The photon counting detector, mounted on the exit plane of a 1m Ebert-Fastie spectrometer, was used to make spectroscopic measurements of the local ion temperature in Alcator C plasmas using impurity emission lines. Alcator experiments on one particular method of RF heating in a tokamak plasma, the launching of Ion Bernstein waves (IBW), are discussed. The O V kinetic temperature increases during IBW injection as the pre-RF plasma density is raised (on a shot-to-shot basis) above the region in which significant increases in the central ion temperature are observed. In addition, ion temperature profiles were measured during Ion Bernstein wave experiments by combining this point derived from the fit to the emission line of O VII with neutral particle analyzer data. The incorporation of the O VII temperature point in the determination of the pre-RF ion temperature profile results in a significant reduction (~0.4 cm) in the characteristic width of this profile. The high resolution and geometric stability of the photon counting detector made possible the measurement of small wavelength shifts (Deltalambda ~ 0.01 A) and, therefore, the determination of small bulk plasma motions (in this case, poloidal rotation of the plasma) through the Doppler shift of impurity emission lines. The Zeeman effect makes a

High-resolution spectral analysis of ammonia near 6.2 μm using a cw EC-QCL coupled with cavity ring-down spectroscopy.

PubMed

Maithani, Sanchi; Mandal, Santanu; Maity, Abhijit; Pal, Mithun; Pradhan, Manik

2018-04-30

We report on the development of a mid-infrared cavity ring-down spectrometer (CRDS) coupled with a continuous wave (cw) external cavity quantum cascade laser (EC-QCL), operating between 6.0 μm and 6.3 μm, for high-resolution spectroscopic studies of ammonia (NH3) which served as a bench-mark molecule in this spectral region. We characterized the EC-QCL based CRDS system in detail and achieved a noise-equivalent absorption (NEA) coefficient of 2.11 × 10-9 cm-1 Hz-1/2 for a 100 Hz data acquisition rate. We thereafter exploited the system for high-resolution spectroscopic analysis of interference-free 10 transition lines of the ν4 fundamental vibrational band of NH3 centred at ∼6.2 μm. We probed the strongest interference-free absorption line RQ(4,3) of ν4, centred at 1613.370 cm-1 for highly-sensitive trace detection of NH3 and subsequently achieved a minimum detection sensitivity (1σ) of 2.78 × 109 molecules per cm3 which translated into the detection limit of 740 parts-per-trillion by volume (pptv/10-12) at a pressure of 115 Torr for an integration time of ∼167 seconds. To demonstrate the efficacy of the present system in real-life applications, we finally measured the mixing ratios of NH3 present in ambient air and human exhaled breath with high sensitivity and molecular specificity.

High-resolution optical measurements of atmospheric winds from space. I - Lower atmosphere molecular absorption

NASA Technical Reports Server (NTRS)

Hays, P. B.

1982-01-01

A high-resolution spectroscopic technique, analogous to that used in the thermosphere to measure the vector wind fields in the upper troposphere and stratosphere, is described which uses narrow features in the spectrum of light scattered from the earth's lower atmosphere to provide Doppler information on atmospheric scattering and absorption. It is demonstrated that vector winds can be measured from a satellite throughout the lower atmosphere, using a multiple-etalon Fabry-Perot interferometer of modest aperture. It is found that molecular oxygen and water vapor absorption lines in the spectrum of sunlight scattered by the atmosphere are Doppler-shifted by the line of sight wind, so that they may be used to monitor the global wind systems in the upper troposphere and stratosphere.

Galaxy And Mass Assembly (GAMA): spectroscopic analysis

NASA Astrophysics Data System (ADS)

Hopkins, A. M.; Driver, S. P.; Brough, S.; Owers, M. S.; Bauer, A. E.; Gunawardhana, M. L. P.; Cluver, M. E.; Colless, M.; Foster, C.; Lara-López, M. A.; Roseboom, I.; Sharp, R.; Steele, O.; Thomas, D.; Baldry, I. K.; Brown, M. J. I.; Liske, J.; Norberg, P.; Robotham, A. S. G.; Bamford, S.; Bland-Hawthorn, J.; Drinkwater, M. J.; Loveday, J.; Meyer, M.; Peacock, J. A.; Tuffs, R.; Agius, N.; Alpaslan, M.; Andrae, E.; Cameron, E.; Cole, S.; Ching, J. H. Y.; Christodoulou, L.; Conselice, C.; Croom, S.; Cross, N. J. G.; De Propris, R.; Delhaize, J.; Dunne, L.; Eales, S.; Ellis, S.; Frenk, C. S.; Graham, Alister W.; Grootes, M. W.; Häußler, B.; Heymans, C.; Hill, D.; Hoyle, B.; Hudson, M.; Jarvis, M.; Johansson, J.; Jones, D. H.; van Kampen, E.; Kelvin, L.; Kuijken, K.; López-Sánchez, Á.; Maddox, S.; Madore, B.; Maraston, C.; McNaught-Roberts, T.; Nichol, R. C.; Oliver, S.; Parkinson, H.; Penny, S.; Phillipps, S.; Pimbblet, K. A.; Ponman, T.; Popescu, C. C.; Prescott, M.; Proctor, R.; Sadler, E. M.; Sansom, A. E.; Seibert, M.; Staveley-Smith, L.; Sutherland, W.; Taylor, E.; Van Waerbeke, L.; Vázquez-Mata, J. A.; Warren, S.; Wijesinghe, D. B.; Wild, V.; Wilkins, S.

2013-04-01

The Galaxy And Mass Assembly (GAMA) survey is a multiwavelength photometric and spectroscopic survey, using the AAOmega spectrograph on the Anglo-Australian Telescope to obtain spectra for up to ˜300 000 galaxies over 280 deg2, to a limiting magnitude of rpet < 19.8 mag. The target galaxies are distributed over 0 < z ≲ 0.5 with a median redshift of z ≈ 0.2, although the redshift distribution includes a small number of systems, primarily quasars, at higher redshifts, up to and beyond z = 1. The redshift accuracy ranges from σv ≈ 50 km s-1 to σv ≈ 100 km s-1 depending on the signal-to-noise ratio of the spectrum. Here we describe the GAMA spectroscopic reduction and analysis pipeline. We present the steps involved in taking the raw two-dimensional spectroscopic images through to flux-calibrated one-dimensional spectra. The resulting GAMA spectra cover an observed wavelength range of 3750 ≲ λ ≲ 8850 Å at a resolution of R ≈ 1300. The final flux calibration is typically accurate to 10-20 per cent, although the reliability is worse at the extreme wavelength ends, and poorer in the blue than the red. We present details of the measurement of emission and absorption features in the GAMA spectra. These measurements are characterized through a variety of quality control analyses detailing the robustness and reliability of the measurements. We illustrate the quality of the measurements with a brief exploration of elementary emission line properties of the galaxies in the GAMA sample. We demonstrate the luminosity dependence of the Balmer decrement, consistent with previously published results, and explore further how Balmer decrement varies with galaxy mass and redshift. We also investigate the mass and redshift dependencies of the [N II]/Hα versus [O III]/Hβ spectral diagnostic diagram, commonly used to discriminate between star forming and nuclear activity in galaxies.

Magnetic resonance spectroscopic imaging at superresolution: Overview and perspectives

NASA Astrophysics Data System (ADS)

Kasten, Jeffrey; Klauser, Antoine; Lazeyras, François; Van De Ville, Dimitri

2016-02-01

The notion of non-invasive, high-resolution spatial mapping of metabolite concentrations has long enticed the medical community. While magnetic resonance spectroscopic imaging (MRSI) is capable of achieving the requisite spatio-spectral localization, it has traditionally been encumbered by significant resolution constraints that have thus far undermined its clinical utility. To surpass these obstacles, research efforts have primarily focused on hardware enhancements or the development of accelerated acquisition strategies to improve the experimental sensitivity per unit time. Concomitantly, a number of innovative reconstruction techniques have emerged as alternatives to the standard inverse discrete Fourier transform (DFT). While perhaps lesser known, these latter methods strive to effect commensurate resolution gains by exploiting known properties of the underlying MRSI signal in concert with advanced image and signal processing techniques. This review article aims to aggregate and provide an overview of the past few decades of so-called "superresolution" MRSI reconstruction methodologies, and to introduce readers to current state-of-the-art approaches. A number of perspectives are then offered as to the future of high-resolution MRSI, with a particular focus on translation into clinical settings.

Magnetic resonance spectroscopic imaging at superresolution: Overview and perspectives.

PubMed

Kasten, Jeffrey; Klauser, Antoine; Lazeyras, François; Van De Ville, Dimitri

2016-02-01

The notion of non-invasive, high-resolution spatial mapping of metabolite concentrations has long enticed the medical community. While magnetic resonance spectroscopic imaging (MRSI) is capable of achieving the requisite spatio-spectral localization, it has traditionally been encumbered by significant resolution constraints that have thus far undermined its clinical utility. To surpass these obstacles, research efforts have primarily focused on hardware enhancements or the development of accelerated acquisition strategies to improve the experimental sensitivity per unit time. Concomitantly, a number of innovative reconstruction techniques have emerged as alternatives to the standard inverse discrete Fourier transform (DFT). While perhaps lesser known, these latter methods strive to effect commensurate resolution gains by exploiting known properties of the underlying MRSI signal in concert with advanced image and signal processing techniques. This review article aims to aggregate and provide an overview of the past few decades of so-called "superresolution" MRSI reconstruction methodologies, and to introduce readers to current state-of-the-art approaches. A number of perspectives are then offered as to the future of high-resolution MRSI, with a particular focus on translation into clinical settings. Copyright © 2015 Elsevier Inc. All rights reserved.

Development and construction of a comprehensive set of research diagnostics for the FLARE user facility

NASA Astrophysics Data System (ADS)

Yoo, Jongsoo; Jara-Almonte, J.; Majeski, S.; Frank, S.; Ji, H.; Yamada, M.

2016-10-01

FLARE (Facility for Laboratory Reconnection Experiments) will be operated as a flexible user facility, and so a complete set of research diagnostics is under development, including magnetic probe arrays, Langmuir probes, Mach probes, spectroscopic probes, and a laser interferometer. In order to accommodate the various requirements of users, large-scale (1 m), variable resolution (0.5-4 cm) magnetic probes have been designed, and are currently being prototyped. Moreover, a fully fiber-coupled laser interferometer has been designed to measure the line-integrated electron density. This fiber-coupled interferometer system will reduce the complexity of alignment processes and minimize maintenance of the system. Finally, improvements to the electrostatic probes and spectroscopic probes currently used in the Magnetic Reconnection Experiment (MRX) are discussed. The specifications of other subsystems, such as integrators and digitizers, are also presented. This work is supported by DoE Contract No. DE-AC0209CH11466.

Preparation of the CARMENES Input Catalogue: Low- and High-resolution Spectroscopy of M dwarfs

NASA Astrophysics Data System (ADS)

Alonso-Floriano, F. J.; Montes, D.; Caballero, J. A.; Klutsch, A.; Jeffers, S.; Reiners, A.; Zechmeister, M.; Lamert, A.; Passegger, V. M.; Mundt, R.; Amado, P. J.; Berdinas, Z. M.; Casal, E.; Cortés-Contreras, M.; Morales, J. C.; Ribas, I.; Rodríguez-López, C.; Quirrenbach, A.

2015-01-01

The identification of the most promising targets for exoplanet hunting is a crucial first step to ensure an efficient use of the CARMENES guaranteed time. To achieve this, we obtained low-resolution (R ˜ 1500) spectra of 752 M (and late K) dwarfs mostly fainter than J = 9 mag with CAFOS. For all of them, we derived spectral types with 0.5 subtypes accuracy. We also studied metallicity and surface gravity through spectral indices, and activity from pEW(Hα). Next, we observed over 600 M dwarfs at higher resolution (R = 30 000-48 000) with FEROS, CAFE and HRS. We determined rotational velocities, v sin{i} (±0.2-0.5 km s^{-1}), and radial velocities, V_r (±0.1-0.2 km s^{-1}), of the observed stars. From our observations, we identified high-activity, low-metallicity and low-gravity stars, single- and double-lined spectroscopic binaries and, specially, fast rotators, which should be discarded from any target list for exoplanet searches. Here we present preliminary results.

An automated image processing routine for segmentation of cell cytoplasms in high-resolution autofluorescence images

NASA Astrophysics Data System (ADS)

Walsh, Alex J.; Skala, Melissa C.

2014-02-01

The heterogeneity of genotypes and phenotypes within cancers is correlated with disease progression and drug-resistant cellular sub-populations. Therefore, robust techniques capable of probing majority and minority cell populations are important both for cancer diagnostics and therapy monitoring. Herein, we present a modified CellProfiler routine to isolate cytoplasmic fluorescence signal on a single cell level from high resolution auto-fluorescence microscopic images.

Using high-resolution displays for high-resolution cardiac data.

PubMed

Goodyer, Christopher; Hodrien, John; Wood, Jason; Kohl, Peter; Brodlie, Ken

2009-07-13

The ability to perform fast, accurate, high-resolution visualization is fundamental to improving our understanding of anatomical data. As the volumes of data increase from improvements in scanning technology, the methods applied to visualization must evolve. In this paper, we address the interactive display of data from high-resolution magnetic resonance imaging scanning of a rabbit heart and subsequent histological imaging. We describe a visualization environment involving a tiled liquid crystal display panel display wall and associated software, which provides an interactive and intuitive user interface. The oView software is an OpenGL application that is written for the VR Juggler environment. This environment abstracts displays and devices away from the application itself, aiding portability between different systems, from desktop PCs to multi-tiled display walls. Portability between display walls has been demonstrated through its use on walls at the universities of both Leeds and Oxford. We discuss important factors to be considered for interactive two-dimensional display of large three-dimensional datasets, including the use of intuitive input devices and level of detail aspects.

Extreme ultraviolet and soft x-ray diagnostics of high-temperature plasmas. Annual progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moos, H W; Armstrong, L Jr

1980-01-01

The work performed from mid-January 1979 through 1980 is described. EUV diagnostic studies have been performed at the Alcator A and C Tokamaks, and on TMX. A toroidal asymmetry has been found in the low density phase of Alcator A. The confinement time of impurities has been measured on Alcator A. Impurity concentrations in the center cell of TMX have been studied using EUV spectroscopic techniques. A time resolving spectrograph with 1024 detector elements is essentially complete.

The CARMENES search for exoplanets around M dwarfs. High-resolution optical and near-infrared spectroscopy of 324 survey stars

NASA Astrophysics Data System (ADS)

Reiners, A.; Zechmeister, M.; Caballero, J. A.; Ribas, I.; Morales, J. C.; Jeffers, S. V.; Schöfer, P.; Tal-Or, L.; Quirrenbach, A.; Amado, P. J.; Kaminski, A.; Seifert, W.; Abril, M.; Aceituno, J.; Alonso-Floriano, F. J.; Ammler-von Eiff, M.; Antona, R.; Anglada-Escudé, G.; Anwand-Heerwart, H.; Arroyo-Torres, B.; Azzaro, M.; Baroch, D.; Barrado, D.; Bauer, F. F.; Becerril, S.; Béjar, V. J. S.; Benítez, D.; Berdinas˜, Z. M.; Bergond, G.; Blümcke, M.; Brinkmöller, M.; del Burgo, C.; Cano, J.; Cárdenas Vázquez, M. C.; Casal, E.; Cifuentes, C.; Claret, A.; Colomé, J.; Cortés-Contreras, M.; Czesla, S.; Díez-Alonso, E.; Dreizler, S.; Feiz, C.; Fernández, M.; Ferro, I. M.; Fuhrmeister, B.; Galadí-Enríquez, D.; Garcia-Piquer, A.; García Vargas, M. L.; Gesa, L.; Galera, V. Gómez; González Hernández, J. I.; González-Peinado, R.; Grözinger, U.; Grohnert, S.; Guàrdia, J.; Guenther, E. W.; Guijarro, A.; Guindos, E. de; Gutiérrez-Soto, J.; Hagen, H.-J.; Hatzes, A. P.; Hauschildt, P. H.; Hedrosa, R. P.; Helmling, J.; Henning, Th.; Hermelo, I.; Hernández Arabí, R.; Hernández Castaño, L.; Hernández Hernando, F.; Herrero, E.; Huber, A.; Huke, P.; Johnson, E. N.; Juan, E. de; Kim, M.; Klein, R.; Klüter, J.; Klutsch, A.; Kürster, M.; Lafarga, M.; Lamert, A.; Lampón, M.; Lara, L. M.; Laun, W.; Lemke, U.; Lenzen, R.; Launhardt, R.; López del Fresno, M.; López-González, J.; López-Puertas, M.; López Salas, J. F.; López-Santiago, J.; Luque, R.; Magán Madinabeitia, H.; Mall, U.; Mancini, L.; Mandel, H.; Marfil, E.; Marín Molina, J. A.; Maroto Fernández, D.; Martín, E. L.; Martín-Ruiz, S.; Marvin, C. J.; Mathar, R. J.; Mirabet, E.; Montes, D.; Moreno-Raya, M. E.; Moya, A.; Mundt, R.; Nagel, E.; Naranjo, V.; Nortmann, L.; Nowak, G.; Ofir, A.; Oreiro, R.; Pallé, E.; Panduro, J.; Pascual, J.; Passegger, V. M.; Pavlov, A.; Pedraz, S.; Pérez-Calpena, A.; Medialdea, D. Pérez; Perger, M.; Perryman, M. A. C.; Pluto, M.; Rabaza, O.; Ramón, A.; Rebolo, R.; Redondo, P.; Reffert, S.; Reinhart, S.; Rhode, P.; Rix, H.-W.; Rodler, F.; Rodríguez, E.; Rodríguez-López, C.; Rodríguez Trinidad, A.; Rohloff, R.-R.; Rosich, A.; Sadegi, S.; Sánchez-Blanco, E.; Sánchez Carrasco, M. A.; Sánchez-López, A.; Sanz-Forcada, J.; Sarkis, P.; Sarmiento, L. F.; Schäfer, S.; Schmitt, J. H. M. M.; Schiller, J.; Schweitzer, A.; Solano, E.; Stahl, O.; Strachan, J. B. P.; Stürmer, J.; Suárez, J. C.; Tabernero, H. M.; Tala, M.; Trifonov, T.; Tulloch, S. M.; Ulbrich, R. G.; Veredas, G.; Vico Linares, J. I.; Vilardell, F.; Wagner, K.; Winkler, J.; Wolthoff, V.; Xu, W.; Yan, F.; Zapatero Osorio, M. R.

2018-04-01

The CARMENES radial velocity (RV) survey is observing 324 M dwarfs to search for any orbiting planets. In this paper, we present the survey sample by publishing one CARMENES spectrum for each M dwarf. These spectra cover the wavelength range 520-1710 nm at a resolution of at least R >80 000, and we measure its RV, Hα emission, and projected rotation velocity. We present an atlas of high-resolution M-dwarf spectra and compare the spectra to atmospheric models. To quantify the RV precision that can be achieved in low-mass stars over the CARMENES wavelength range, we analyze our empirical information on the RV precision from more than 6500 observations. We compare our high-resolution M-dwarf spectra to atmospheric models where we determine the spectroscopic RV information content, Q, and signal-to-noise ratio. We find that for all M-type dwarfs, the highest RV precision can be reached in the wavelength range 700-900 nm. Observations at longer wavelengths are equally precise only at the very latest spectral types (M8 and M9). We demonstrate that in this spectroscopic range, the large amount of absorption features compensates for the intrinsic faintness of an M7 star. To reach an RV precision of 1 m s-1 in very low mass M dwarfs at longer wavelengths likely requires the use of a 10 m class telescope. For spectral types M6 and earlier, the combination of a red visual and a near-infrared spectrograph is ideal to search for low-mass planets and to distinguish between planets and stellar variability. At a 4 m class telescope, an instrument like CARMENES has the potential to push the RV precision well below the typical jitter level of 3-4 m s-1.

High-cadence Imaging and Imaging Spectroscopy at the GREGOR Solar Telescope—A Collaborative Research Environment for High-resolution Solar Physics

NASA Astrophysics Data System (ADS)

Denker, Carsten; Kuckein, Christoph; Verma, Meetu; González Manrique, Sergio J.; Diercke, Andrea; Enke, Harry; Klar, Jochen; Balthasar, Horst; Louis, Rohan E.; Dineva, Ekaterina

2018-05-01

In high-resolution solar physics, the volume and complexity of photometric, spectroscopic, and polarimetric ground-based data significantly increased in the last decade, reaching data acquisition rates of terabytes per hour. This is driven by the desire to capture fast processes on the Sun and the necessity for short exposure times “freezing” the atmospheric seeing, thus enabling ex post facto image restoration. Consequently, large-format and high-cadence detectors are nowadays used in solar observations to facilitate image restoration. Based on our experience during the “early science” phase with the 1.5 m GREGOR solar telescope (2014–2015) and the subsequent transition to routine observations in 2016, we describe data collection and data management tailored toward image restoration and imaging spectroscopy. We outline our approaches regarding data processing, analysis, and archiving for two of GREGOR’s post-focus instruments (see http://gregor.aip.de), i.e., the GREGOR Fabry–Pérot Interferometer (GFPI) and the newly installed High-Resolution Fast Imager (HiFI). The heterogeneous and complex nature of multidimensional data arising from high-resolution solar observations provides an intriguing but also a challenging example for “big data” in astronomy. The big data challenge has two aspects: (1) establishing a workflow for publishing the data for the whole community and beyond and (2) creating a collaborative research environment (CRE), where computationally intense data and postprocessing tools are colocated and collaborative work is enabled for scientists of multiple institutes. This requires either collaboration with a data center or frameworks and databases capable of dealing with huge data sets based on virtual observatory (VO) and other community standards and procedures.

High definition infrared spectroscopic imaging for lymph node histopathology.

PubMed

Leslie, L Suzanne; Wrobel, Tomasz P; Mayerich, David; Bindra, Snehal; Emmadi, Rajyasree; Bhargava, Rohit

2015-01-01

Chemical imaging is a rapidly emerging field in which molecular information within samples can be used to predict biological function and recognize disease without the use of stains or manual identification. In Fourier transform infrared (FT-IR) spectroscopic imaging, molecular absorption contrast provides a large signal relative to noise. Due to the long mid-IR wavelengths and sub-optimal instrument design, however, pixel sizes have historically been much larger than cells. This limits both the accuracy of the technique in identifying small regions, as well as the ability to visualize single cells. Here we obtain data with micron-sized sampling using a tabletop FT-IR instrument, and demonstrate that the high-definition (HD) data lead to accurate identification of multiple cells in lymph nodes that was not previously possible. Highly accurate recognition of eight distinct classes - naïve and memory B cells, T cells, erythrocytes, connective tissue, fibrovascular network, smooth muscle, and light and dark zone activated B cells was achieved in healthy, reactive, and malignant lymph node biopsies using a random forest classifier. The results demonstrate that cells currently identifiable only through immunohistochemical stains and cumbersome manual recognition of optical microscopy images can now be distinguished to a similar level through a single IR spectroscopic image from a lymph node biopsy.

The high resolution submillimetre spectrum of the stratosphere

NASA Technical Reports Server (NTRS)

Carli, B.

1984-01-01

The structure of the stratospheric spectrum, measured with a resolution of 0.0033/cm unapodized in the 7-90/cm spectral interval is described. The spectra from measurements recorded on April 24, 1979 from a balloon-borne platform at about 39 km altitude launched from the National Scientific Balloon Facility of Palestine, TX are presented. The main spectroscopic constituents include a few strong and saturated lines due to the rotational spectrum of water vapor, to magnetic dipole transitions of oxygen, and to the rotational spectrum of ozone. It is shown that the lines of ozone prevent the positive identification of the contribution to the submillimeter spectrum of several minor constituents such as HF, HCl, HCN, HNO3, and N2O. The assignments which are possible in the spectra are revised.

High-pressure spectroscopic measurement on diffusion with a diamond-anvil cell

NASA Astrophysics Data System (ADS)

Aoki, K.; Katoh, Eriko; Yamawaki, H.; Fujihisa, H.; Sakashita, M.

2003-04-01

We report a diamond-anvil-cell (DAC) technique developed for spectroscopic measurement on the diffusion process in molecular solids at high pressure. The diffusion processes of atoms, molecules, or their ionic species are investigated for a bilayer specimen by measuring the variation of infrared vibrational spectra with time. The experimental procedures for the protonic and molecular diffusion measurements on ice at 400 K and 10.2 GPa are presented as an example study. The in situ spectroscopic technique with a DAC significantly extends the pressure range accessible for diffusion measurement. The diffusion process at a rate of 10-16-10-14 m2/s can currently be observed at temperatures of 300-600 K and pressures up to several tens of gigaPascals.

High Spatiotemporal Resolution Prostate MRI

DTIC Science & Technology

2016-09-01

1 AD AWARD NUMBER: W81XWH-15-1-0341 TITLE: High Spatiotemporal Resolution Prostate MRI PRINCIPAL INVESTIGATOR: Stephen J. Riederer CONTRACTING...REPORT TYPE Annual 3. DATES COVERED 15 Aug 2015 - 14 Aug 2016 4. TITLE AND SUBTITLE High Spatiotemporal Resolution Prostate MRI 5a. CONTRACT NUMBER...improved means using MRI for detecting prostate cancer with the potential for differentiating disease aggressiveness. The hypothesis is that dynamic

High-resolution ultraviolet radiation fields of classical T Tauri stars

DOE Office of Scientific and Technical Information (OSTI.GOV)

France, Kevin; Schindhelm, Eric; Bergin, Edwin A.

2014-04-01

The far-ultraviolet (FUV; 912-1700 Å) radiation field from accreting central stars in classical T Tauri systems influences the disk chemistry during the period of giant planet formation. The FUV field may also play a critical role in determining the evolution of the inner disk (r < 10 AU), from a gas- and dust-rich primordial disk to a transitional system where the optically thick warm dust distribution has been depleted. Previous efforts to measure the true stellar+accretion-generated FUV luminosity (both hot gas emission lines and continua) have been complicated by a combination of low-sensitivity and/or low-spectral resolution and did not includemore » the contribution from the bright Lyα emission line. In this work, we present a high-resolution spectroscopic study of the FUV radiation fields of 16 T Tauri stars whose dust disks display a range of evolutionary states. We include reconstructed Lyα line profiles and remove atomic and molecular disk emission (from H{sub 2} and CO fluorescence) to provide robust measurements of both the FUV continuum and hot gas lines (e.g., Lyα, N V, C IV, He II) for an appreciable sample of T Tauri stars for the first time. We find that the flux of the typical classical T Tauri star FUV radiation field at 1 AU from the central star is ∼10{sup 7} times the average interstellar radiation field. The Lyα emission line contributes an average of 88% of the total FUV flux, with the FUV continuum accounting for an average of 8%. Both the FUV continuum and Lyα flux are strongly correlated with C IV flux, suggesting that accretion processes dominate the production of both of these components. On average, only ∼0.5% of the total FUV flux is emitted between the Lyman limit (912 Å) and the H{sub 2} (0-0) absorption band at 1110 Å. The total and component-level high-resolution radiation fields are made publicly available in machine-readable format.« less

High Resolution Image Reconstruction from Projection of Low Resolution Images DIffering in Subpixel Shifts

NASA Technical Reports Server (NTRS)

Mareboyana, Manohar; Le Moigne-Stewart, Jacqueline; Bennett, Jerome

2016-01-01

In this paper, we demonstrate a simple algorithm that projects low resolution (LR) images differing in subpixel shifts on a high resolution (HR) also called super resolution (SR) grid. The algorithm is very effective in accuracy as well as time efficiency. A number of spatial interpolation techniques using nearest neighbor, inverse-distance weighted averages, Radial Basis Functions (RBF) etc. used in projection yield comparable results. For best accuracy of reconstructing SR image by a factor of two requires four LR images differing in four independent subpixel shifts. The algorithm has two steps: i) registration of low resolution images and (ii) shifting the low resolution images to align with reference image and projecting them on high resolution grid based on the shifts of each low resolution image using different interpolation techniques. Experiments are conducted by simulating low resolution images by subpixel shifts and subsampling of original high resolution image and the reconstructing the high resolution images from the simulated low resolution images. The results of accuracy of reconstruction are compared by using mean squared error measure between original high resolution image and reconstructed image. The algorithm was tested on remote sensing images and found to outperform previously proposed techniques such as Iterative Back Projection algorithm (IBP), Maximum Likelihood (ML), and Maximum a posterior (MAP) algorithms. The algorithm is robust and is not overly sensitive to the registration inaccuracies.

High resolution spectroscopy from ground and space: Introduction

NASA Astrophysics Data System (ADS)

Ward, William E.

In contrast to the broad brush approach often used for the sounding of atmospheric constituents, high resolution spectroscopy is a refined, efficient and often elegant tool which uses small spectral regions to probe specific phenomena. Application areas range from wind and temperature measurements in terrestrial and planetary atmospheres, to magnetic field measurements on the sun. In most cases, subtle changes in line shape or line position are used with a priori information to generate the geophysical information of interest. Use of this technique for space applications started in the 1960's and was a natural extension of the spectroscopic heritage which was started by Fabry and Perot and Michelson over 100 year ago. This field has evolved over the past 50 years in response to refinements in detector technologies, manufacturing techniques and the development of active techniques using lasers. This session will trace the evolution of these techniques over the past half-century and showcase the state-of-the-art today. Within Canada, Gordon Shepherd has played a hand in many of the developments in this technique. This introduction will briefly summarize this field and provide a short historical sketch of Shepherd's contributions as a lead into his keynote review of this topic.

PEPSI: the Potsdam Echelle Polarimetric and Spectroscopic Instrument for the LBT

NASA Astrophysics Data System (ADS)

Strassmeier, K. G.; Woche, M.; Ilyin, I.; Popow, E.; Bauer, S.-M.; Dionies, F.; Fechner, T.; Weber, M.; Hofmann, A.; Storm, J.; Materne, R.; Bittner, W.; Bartus, J.; Granzer, T.; Denker, C.; Carroll, T.; Kopf, M.; DiVarano, I.; Beckert, E.; Lesser, M.

2008-07-01

We present the status of PEPSI, the bench-mounted fibre-fed and stabilized "Potsdam Echelle Polarimetric and Spectroscopic Instrument" for the 2×8.4m Large Binocular Telescope in southern Arizona. PEPSI is under construction at AIP and is scheduled for first light in 2009/10. Its ultra-high-resolution mode will deliver an unprecedented spectral resolution of approximately R=310,000 at high efficiency throughout the entire optical/red wavelength range 390-1050nm without the need for adaptive optics. Besides its polarimetric Stokes IQUV mode, the capability to cover the entire optical range in three exposures at resolutions of 40,000, 130,000 and 310,000 will surpass all existing facilities in terms of light-gathering-power times spectral-coverage product. A solar feed will make use of the spectrograph also during day time. As such, we hope that PEPSI will be the most powerful spectrometer of its kind for the years to come.

Spectroscopic diagnostics of plasma during laser processing of aluminium

NASA Astrophysics Data System (ADS)

Lober, R.; Mazumder, J.

2007-10-01

The role of the plasma in laser-metal interaction is of considerable interest due to its influence in the energy transfer mechanism in industrial laser materials processing. A 10 kW CO2 laser was used to study its interaction with aluminium under an argon environment. The objective was to determine the absorption and refraction of the laser beam through the plasma during the processing of aluminium. Laser processing of aluminium is becoming an important topic for many industries, including the automobile industry. The spectroscopic relative line to continuum method was used to determine the electron temperature distribution within the plasma by investigating the 4158 Å Ar I line emission and the continuum adjacent to it. The plasmas are induced in 1.0 atm pure Ar environment over a translating Al target, using f/7 and 10 kW CO2 laser. Spectroscopic data indicated that the plasma composition and behaviour were Ar-dominated. Experimental results indicated the plasma core temperature to be 14 000-15 300 K over the incident range of laser powers investigated from 5 to 7 kW. It was found that 7.5-29% of the incident laser power was absorbed by the plasma. Cross-section analysis of the melt pools from the Al samples revealed the absence of any key-hole formation and confirmed that the energy transfer mechanism in the targets was conduction dominated for the reported range of experimental data.

Constraints on the Profiles of Total Water PDF in AGCMs from AIRS and a High-Resolution Model

NASA Technical Reports Server (NTRS)

Molod, Andrea

2012-01-01

Atmospheric general circulation model (AGCM) cloud parameterizations generally include an assumption about the subgrid-scale probability distribution function (PDF) of total water and its vertical profile. In the present study, the Atmospheric Infrared Sounder (AIRS) monthly-mean cloud amount and relative humidity fields are used to compute a proxy for the second moment of an AGCM total water PDF called the RH01 diagnostic, which is the AIRS mean relative humidity for cloud fractions of 0.1 or less. The dependence of the second moment on horizontal grid resolution is analyzed using results from a high-resolution global model simulation.The AIRS-derived RH01 diagnostic is generally larger near the surface than aloft, indicating a narrower PDF near the surface, and varies with the type of underlying surface. High-resolution model results show that the vertical structure of profiles of the AGCM PDF second moment is unchanged as the grid resolution changes from 200 to 100 to 50 km, and that the second-moment profiles shift toward higher values with decreasing grid spacing.Several Goddard Earth Observing System, version 5 (GEOS-5), AGCM simulations were performed with several choices for the profile of the PDF second moment. The resulting cloud and relative humidity fields were shown to be quite sensitive to the prescribed profile, and the use of a profile based on the AIRS-derived proxy results in improvements relative to observational estimates. The AIRS-guided total water PDF profiles, including their dependence on underlying surface type and on horizontal resolution, have been implemented in the version of the GEOS-5 AGCM used for publicly released simulations.

imVisIR - a new tool for high resolution soil characterisation

NASA Astrophysics Data System (ADS)

Steffens, Markus; Buddenbaum, Henning

2014-05-01

The physical and chemical heterogeneities of soils are the source of a vast functional diversity of soil properties in a multitude of spatial domains. But many studies do not consider the spatial variability of soil types, diagnostic horizons and properties. These lateral and vertical heterogeneities of soils or soil horizons are mostly neglected due to the limitations in the available soil data and missing techniques to gather the information. We present an imaging technique that enables the spatially accurate, high resolution assessment (63×63 µm2 per pixel) of complete soil profiles consisting of mineral and organic horizons. We used a stainless steel box (100×100×300 mm3) to sample various soil types and a hyperspectral camera to record the bidirectional reflectance of the large undisturbed soil samples in the visible and near infrared (Vis-NIR) part of the electromagnetic spectrum (400-1000 nm in 160 spectral bands). Various statistical, geostatistical and image processing tools were used to 1) assess the spatial variability of the soil profile as a whole; 2) classify diagnostic horizons; 3) extrapolate elemental concentrations of small sampling areas to the complete image and calculate high resolution chemometric maps of up to five elements (C, N, Al, Fe, Mn); and 4) derive maps of the chemical composition of soil organic matter. Imaging Vis-NIR (imVisIR) has the potential to significantly improve soil classification, assessment of elemental budgets and balances and the understanding of soil forming processes and mechanisms. It will help to identify areas of interest for techniques working on smaller scales and enable the upscaling and referencing of this information to the complete pedon.

High-Resolution X-Ray Telescopes

NASA Technical Reports Server (NTRS)

ODell, Stephen L.; Brissenden, Roger J.; Davis, William; Elsner, Ronald F.; Elvis, Martin; Freeman, Mark; Gaetz, Terry; Gorenstein, Paul; Gubarev, Mikhail V.

2010-01-01

Fundamental needs for future x-ray telescopes: a) Sharp images => excellent angular resolution. b) High throughput => large aperture areas. Generation-X optics technical challenges: a) High resolution => precision mirrors & alignment. b) Large apertures => lots of lightweight mirrors. Innovation needed for technical readiness: a) 4 top-level error terms contribute to image size. b) There are approaches to controlling those errors. Innovation needed for manufacturing readiness. Programmatic issues are comparably challenging.

Proposal of one-shot-type spectroscopic-tomography for non-invasive medical-measurement

NASA Astrophysics Data System (ADS)

Sato, Shun; Fujiwara, Masaru; Abeygunawardhana, Pradeep K. W.; Suzuki, Satoru; Nishiyama, Akira; Ishimaru, Ichiro

2013-06-01

The one-shot-type spectroscopic-tomography is proposed to develop the medical-patient-condition monitoring systems. The optical-setup is configured with the relative-inclined phase-shifter for improving the time resolution and the phase-shift array for improving visibility. We obtained the line-spectroscopic imaging and could recognize the Hg bright-line-spectrum that is a component of the light-source. The realization of the optical stethoscope for early diagnosis of cancer can be expected by obtaining the 2-dimensional spectroscopic distribution with rotating interferometer.

ORBITAL SOLUTIONS FOR TWO YOUNG, LOW-MASS SPECTROSCOPIC BINARIES IN OPHIUCHUS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosero, V.; Prato, L.; Wasserman, L. H.

2011-01-15

We report the orbital parameters for ROXR1 14 and RX J1622.7-2325Nw, two young, low-mass, and double-lined spectroscopic binaries recently discovered in the Ophiuchus star-forming region. Accurate orbital solutions were determined from over a dozen high-resolution spectra taken with the Keck II and Gemini South telescopes. These objects are T Tauri stars with mass ratios close to unity and periods of {approx}5 and {approx}3 days, respectively. In particular, RX J1622.7-2325Nw shows a non-circularized orbit with an eccentricity of 0.30, higher than any other short-period pre-main-sequence (PMS) spectroscopic binary known to date. We speculate that the orbit of RX J1622.7-2325Nw has notmore » yet circularized because of the perturbing action of a {approx}1'' companion, itself a close visual pair. A comparison of known young spectroscopic binaries (SBs) and main-sequence (MS) SBs in the eccentricity-period plane shows an indistinguishable distribution of the two populations, implying that orbital circularization occurs in the first 1 Myr of a star's lifetime. With the results presented in this paper we increase by {approx}4% the small sample of PMS spectroscopic binary stars with known orbital elements.« less

High resolution FTIR imaging provides automated discrimination and detection of single malaria parasite infected erythrocytes on glass.

PubMed

Perez-Guaita, David; Andrew, Dean; Heraud, Philip; Beeson, James; Anderson, David; Richards, Jack; Wood, Bayden R

2016-06-23

New highly sensitive tools for malaria diagnostics are urgently needed to enable the detection of infection in asymptomatic carriers and patients with low parasitemia. In pursuit of a highly sensitive diagnostic tool that can identify parasite infections at the single cell level, we have been exploring Fourier transform infrared (FTIR) microscopy using a Focal Plane Array (FPA) imaging detector. Here we report for the first time the application of a new optic configuration developed by Agilent that incorporates 25× condenser and objective Cassegrain optics with a high numerical aperture (NA = 0.81) along with additional high magnification optics within the microscope to provide 0.66 micron pixel resolution (total IR system magnification of 61×) to diagnose malaria parasites at the single cell level on a conventional glass microscope slide. The high quality images clearly resolve the parasite's digestive vacuole demonstrating sub-cellular resolution using this approach. Moreover, we have developed an algorithm that first detects the cells in the infrared image, and secondly extracts the average spectrum. The average spectrum is then run through a model based on Partial Least Squares-Discriminant Analysis (PLS-DA), which diagnoses unequivocally the infected from normal cells. The high quality images, and the fact this measurement can be achieved without a synchrotron source on a conventional glass slide, shows promise as a potential gold standard for malaria detection at the single cell level.

High-resolution scanning precession electron diffraction: Alignment and spatial resolution.

PubMed

Barnard, Jonathan S; Johnstone, Duncan N; Midgley, Paul A

2017-03-01

Methods are presented for aligning the pivot point of a precessing electron probe in the scanning transmission electron microscope (STEM) and for assessing the spatial resolution in scanning precession electron diffraction (SPED) experiments. The alignment procedure is performed entirely in diffraction mode, minimising probe wander within the bright-field (BF) convergent beam electron diffraction (CBED) disk and is used to obtain high spatial resolution SPED maps. Through analysis of the power spectra of virtual bright-field images extracted from the SPED data, the precession-induced blur was measured as a function of precession angle. At low precession angles, SPED spatial resolution was limited by electronic noise in the scan coils; whereas at high precession angles SPED spatial resolution was limited by tilt-induced two-fold astigmatism caused by the positive spherical aberration of the probe-forming lens. Copyright © 2016 Elsevier B.V. All rights reserved.

Apertureless near-field/far-field CW two-photon microscope for biological and material imaging and spectroscopic applications.

PubMed

Nowak, Derek B; Lawrence, A J; Sánchez, Erik J

2010-12-10

We present the development of a versatile spectroscopic imaging tool to allow for imaging with single-molecule sensitivity and high spatial resolution. The microscope allows for near-field and subdiffraction-limited far-field imaging by integrating a shear-force microscope on top of a custom inverted microscope design. The instrument has the ability to image in ambient conditions with optical resolutions on the order of tens of nanometers in the near field. A single low-cost computer controls the microscope with a field programmable gate array data acquisition card. High spatial resolution imaging is achieved with an inexpensive CW multiphoton excitation source, using an apertureless probe and simplified optical pathways. The high-resolution, combined with high collection efficiency and single-molecule sensitive optical capabilities of the microscope, are demonstrated with a low-cost CW laser source as well as a mode-locked laser source.

New concept high-speed and high-resolution color scanner

NASA Astrophysics Data System (ADS)

Nakashima, Keisuke; Shinoda, Shin'ichi; Konishi, Yoshiharu; Sugiyama, Kenji; Hori, Tetsuya

2003-05-01

We have developed a new concept high-speed and high-resolution color scanner (Blinkscan) using digital camera technology. With our most advanced sub-pixel image processing technology, approximately 12 million pixel image data can be captured. High resolution imaging capability allows various uses such as OCR, color document read, and document camera. The scan time is only about 3 seconds for a letter size sheet. Blinkscan scans documents placed "face up" on its scan stage and without any special illumination lights. Using Blinkscan, a high-resolution color document can be easily inputted into a PC at high speed, a paperless system can be built easily. It is small, and since the occupancy area is also small, setting it on an individual desk is possible. Blinkscan offers the usability of a digital camera and accuracy of a flatbed scanner with high-speed processing. Now, about several hundred of Blinkscan are mainly shipping for the receptionist operation in a bank and a security. We will show the high-speed and high-resolution architecture of Blinkscan. Comparing operation-time with conventional image capture device, the advantage of Blinkscan will make clear. And image evaluation for variety of environment, such as geometric distortions or non-uniformity of brightness, will be made.

Tip-enhanced Raman scattering (TERS) and high-resolution bio nano-analysis--a comparison.

PubMed

Deckert-Gaudig, Tanja; Deckert, Volker

2010-10-14

This perspective presents and assesses the development and capabilities of tip-enhanced Raman scattering (TERS) since its discovery in 2000. So far, this technique has proven to be valuable for studies of a variety of inorganic, organic and biochemical specimens. Due to its ability to provide chemical and topographic characterization in a single experiment at a sub-100 nm resolution, TERS has gained importance in super-resolution structural analysis. In this contribution the focus is set on applications with relevance in the biology and medical fields. The potential and challenges of this near-field technique are discussed with respect to state-of-the-art microscopic and spectroscopic imaging methods. Furthermore, possible ways to surpass current boundaries and an outlook to future projects are presented.

Breath Analysis Using Laser Spectroscopic Techniques: Breath Biomarkers, Spectral Fingerprints, and Detection Limits

PubMed Central

Wang, Chuji; Sahay, Peeyush

2009-01-01

Breath analysis, a promising new field of medicine and medical instrumentation, potentially offers noninvasive, real-time, and point-of-care (POC) disease diagnostics and metabolic status monitoring. Numerous breath biomarkers have been detected and quantified so far by using the GC-MS technique. Recent advances in laser spectroscopic techniques and laser sources have driven breath analysis to new heights, moving from laboratory research to commercial reality. Laser spectroscopic detection techniques not only have high-sensitivity and high-selectivity, as equivalently offered by the MS-based techniques, but also have the advantageous features of near real-time response, low instrument costs, and POC function. Of the approximately 35 established breath biomarkers, such as acetone, ammonia, carbon dioxide, ethane, methane, and nitric oxide, 14 species in exhaled human breath have been analyzed by high-sensitivity laser spectroscopic techniques, namely, tunable diode laser absorption spectroscopy (TDLAS), cavity ringdown spectroscopy (CRDS), integrated cavity output spectroscopy (ICOS), cavity enhanced absorption spectroscopy (CEAS), cavity leak-out spectroscopy (CALOS), photoacoustic spectroscopy (PAS), quartz-enhanced photoacoustic spectroscopy (QEPAS), and optical frequency comb cavity-enhanced absorption spectroscopy (OFC-CEAS). Spectral fingerprints of the measured biomarkers span from the UV to the mid-IR spectral regions and the detection limits achieved by the laser techniques range from parts per million to parts per billion levels. Sensors using the laser spectroscopic techniques for a few breath biomarkers, e.g., carbon dioxide, nitric oxide, etc. are commercially available. This review presents an update on the latest developments in laser-based breath analysis. PMID:22408503

Evaluation of prospective motion correction of high-resolution 3D-T2-FLAIR acquisitions in epilepsy patients.

PubMed

Vos, Sjoerd B; Micallef, Caroline; Barkhof, Frederik; Hill, Andrea; Winston, Gavin P; Ourselin, Sebastien; Duncan, John S

2018-03-02

T2-FLAIR is the single most sensitive MRI contrast to detect lesions underlying focal epilepsies but 3D sequences used to obtain isotropic high-resolution images are susceptible to motion artefacts. Prospective motion correction (PMC) - demonstrated to improve 3D-T1 image quality in a pediatric population - was applied to high-resolution 3D-T2-FLAIR scans in adult epilepsy patients to evaluate its clinical benefit. Coronal 3D-T2-FLAIR scans were acquired with a 1mm isotropic resolution on a 3T MRI scanner. Two expert neuroradiologists reviewed 40 scans without PMC and 40 with navigator-based PMC. Visual assessment addressed six criteria of image quality (resolution, SNR, WM-GM contrast, intensity homogeneity, lesion conspicuity, diagnostic confidence) on a seven-point Likert scale (from non-diagnostic to outstanding). SNR was also objectively quantified within the white matter. PMC scans had near-identical scores on the criteria of image quality to non-PMC scans, with the notable exception that intensity homogeneity was generally worse. Using PMC, the percentage of scans with bad image quality was substantially lower than without PMC (3.25% vs. 12.5%) on the other five criteria. Quantitative SNR estimates revealed that PMC and non-PMC had no significant difference in SNR (P=0.07). Application of prospective motion correction to 3D-T2-FLAIR sequences decreased the percentage of low-quality scans, reducing the number of scans that need to be repeated to obtain clinically useful data. Copyright © 2018 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Spectroscopic observations with the Stratospheric Observatory for Infrared Astronomy (SOFIA)

NASA Astrophysics Data System (ADS)

Becklin, E. E.; Tielens, A. G. G. M.; Callis, H. H. S.

The joint US and German SOFIA project to develop and operate a 2.5-meter infrared airborne telescope in a Boeing 747-SP is now in its final stages of development. Flying in the stratosphere, SOFIA allows observations through the infrared and submillimeter region, with an average transmission of greater than 80%. SOFIA is characterized by a wide instrument complement ranging from broadband imagers, through moderate resolution spectrographs capable of resolving broad features due to dust and large molecules, to high-resolution spectrometers suitable for kinematic studies of molecular and atomic gas lines at km/s resolution. This broad range in instruments will enable SOFIA to make unique contributions to a broad array of science topics. First science flights will begin in 2009 and the observatory is expected to operate for over 20 years. The sensitivity, characteristics, science instrument complement, and examples of first light spectroscopic science are discussed.

High-resolution echocardiography

NASA Technical Reports Server (NTRS)

Nathan, R.

1979-01-01

High resolution computer aided ultrasound system provides two-and three-dimensional images of beating heart from many angles. System provides means for determining whether small blood vessels around the heart are blocked or if heart wall is moving normally without interference of dead and noncontracting muscle tissue.

21 CFR 892.1700 - Diagnostic x-ray high voltage generator.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Diagnostic x-ray high voltage generator. 892.1700... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.1700 Diagnostic x-ray high voltage generator. (a) Identification. A diagnostic x-ray high voltage generator is a device that is intended to...

21 CFR 892.1700 - Diagnostic x-ray high voltage generator.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Diagnostic x-ray high voltage generator. 892.1700... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.1700 Diagnostic x-ray high voltage generator. (a) Identification. A diagnostic x-ray high voltage generator is a device that is intended to...

21 CFR 892.1700 - Diagnostic x-ray high voltage generator.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Diagnostic x-ray high voltage generator. 892.1700... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.1700 Diagnostic x-ray high voltage generator. (a) Identification. A diagnostic x-ray high voltage generator is a device that is intended to...

21 CFR 892.1700 - Diagnostic x-ray high voltage generator.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Diagnostic x-ray high voltage generator. 892.1700... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.1700 Diagnostic x-ray high voltage generator. (a) Identification. A diagnostic x-ray high voltage generator is a device that is intended to...

21 CFR 892.1700 - Diagnostic x-ray high voltage generator.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Diagnostic x-ray high voltage generator. 892.1700... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.1700 Diagnostic x-ray high voltage generator. (a) Identification. A diagnostic x-ray high voltage generator is a device that is intended to...

Optimizing hydroxyl airglow retrievals from long-slit astronomical spectroscopic observations

NASA Astrophysics Data System (ADS)

Franzen, Christoph; Hibbins, Robert Edward; Espy, Patrick Joseph; Djupvik, Anlaug Amanda

2017-08-01

Astronomical spectroscopic observations from ground-based telescopes contain background emission lines from the terrestrial atmosphere's airglow. In the near infrared, this background is composed mainly of emission from Meinel bands of hydroxyl (OH), which is produced in highly excited vibrational states by reduction of ozone near 90 km. This emission contains a wealth of information on the chemical and dynamical state of the Earth's atmosphere. However, observation strategies and data reduction processes are usually optimized to minimize the influence of these features on the astronomical spectrum. Here we discuss a measurement technique to optimize the extraction of the OH airglow signal itself from routine J-, H-, and K-band long-slit astronomical spectroscopic observations. As an example, we use data recorded from a point-source observation by the Nordic Optical Telescope's intermediate-resolution spectrograph, which has a spatial resolution of approximately 100 m at the airglow layer. Emission spectra from the OH vibrational manifold from v' = 9 down to v' = 3, with signal-to-noise ratios up to 280, have been extracted from 10.8 s integrations. Rotational temperatures representative of the background atmospheric temperature near 90 km, the mesosphere and lower thermosphere region, can be fitted to the OH rotational lines with an accuracy of around 0.7 K. Using this measurement and analysis technique, we derive a rotational temperature distribution with v' that agrees with atmospheric model conditions and the preponderance of previous work. We discuss the derived rotational temperatures from the different vibrational bands and highlight the potential for both the archived and future observations, which are at unprecedented spatial and temporal resolutions, to contribute toward the resolution of long-standing problems in atmospheric physics.

High-resolution land cover classification using low resolution global data

NASA Astrophysics Data System (ADS)

Carlotto, Mark J.

2013-05-01

A fusion approach is described that combines texture features from high-resolution panchromatic imagery with land cover statistics derived from co-registered low-resolution global databases to obtain high-resolution land cover maps. The method does not require training data or any human intervention. We use an MxN Gabor filter bank consisting of M=16 oriented bandpass filters (0-180°) at N resolutions (3-24 meters/pixel). The size range of these spatial filters is consistent with the typical scale of manmade objects and patterns of cultural activity in imagery. Clustering reduces the complexity of the data by combining pixels that have similar texture into clusters (regions). Texture classification assigns a vector of class likelihoods to each cluster based on its textural properties. Classification is unsupervised and accomplished using a bank of texture anomaly detectors. Class likelihoods are modulated by land cover statistics derived from lower resolution global data over the scene. Preliminary results from a number of Quickbird scenes show our approach is able to classify general land cover features such as roads, built up area, forests, open areas, and bodies of water over a wide range of scenes.

Whole-animal imaging with high spatio-temporal resolution

NASA Astrophysics Data System (ADS)

Chhetri, Raghav; Amat, Fernando; Wan, Yinan; Höckendorf, Burkhard; Lemon, William C.; Keller, Philipp J.

2016-03-01

We developed isotropic multiview (IsoView) light-sheet microscopy in order to image fast cellular dynamics, such as cell movements in an entire developing embryo or neuronal activity throughput an entire brain or nervous system, with high resolution in all dimensions, high imaging speeds, good physical coverage and low photo-damage. To achieve high temporal resolution and high spatial resolution at the same time, IsoView microscopy rapidly images large specimens via simultaneous light-sheet illumination and fluorescence detection along four orthogonal directions. In a post-processing step, these four views are then combined by means of high-throughput multiview deconvolution to yield images with a system resolution of ≤ 450 nm in all three dimensions. Using IsoView microscopy, we performed whole-animal functional imaging of Drosophila embryos and larvae at a spatial resolution of 1.1-2.5 μm and at a temporal resolution of 2 Hz for up to 9 hours. We also performed whole-brain functional imaging in larval zebrafish and multicolor imaging of fast cellular dynamics across entire, gastrulating Drosophila embryos with isotropic, sub-cellular resolution. Compared with conventional (spatially anisotropic) light-sheet microscopy, IsoView microscopy improves spatial resolution at least sevenfold and decreases resolution anisotropy at least threefold. Compared with existing high-resolution light-sheet techniques, such as lattice lightsheet microscopy or diSPIM, IsoView microscopy effectively doubles the penetration depth and provides subsecond temporal resolution for specimens 400-fold larger than could previously be imaged.

Characterizing Time to Diagnostic Resolution After an Abnormal Cancer Screening Exam in Older Adult Participants in the Ohio Patient Navigation Research Program.

PubMed

DeSalvo, Jennifer M; Young, Gregory S; Krok-Schoen, Jessica L; Paskett, Electra D

2017-06-01

This study aims to test the effectiveness of a patient navigation (PN) intervention to reduce time to diagnostic resolution among older adults age ≥65 years versus those <65 years with abnormal breast, cervical, or colorectal cancer screening exams participating in the Ohio Patient Navigation Research Program (OPNRP). The OPNRP utilized a nested cohort group-randomized trial design to randomize 862 participants ( n = 67 for ≥65 years; n = 795 for <65 years) to PN or usual care conditions. A shared frailty Cox model tested the effect of PN on time to resolution. Older adult participants randomized to PN achieved a 6-month resolution rate that was 127% higher than those randomized to usual care ( p = .001). This effect was not significantly different from participants <65 years. PN significantly reduced time to diagnostic resolution among older adults beginning 6 months after an abnormal cancer screening exam. Health care systems should include this population in PN programs to reduce cancer disparities.

Spectroscopic classification of Gaia16alf

NASA Astrophysics Data System (ADS)

Onori, F.; Fraser, M.; Jonker, P.; Wyrzykowski, L.; Blagorodnova, N.; Mattila, S.

2016-04-01

We report the spectroscopic classification of Gaia16alf, from medium resolution (R~1000; 330-990nm) spectra taken with the William Herschel Telescope + ISIS + R300B/R158R on the night of 2016 April 19. The spectrum is consistent with that of a Type Ia SN a few days before maximum light at a redshift of z=0.094.

Pair Identity and Smooth Variation Rules Applicable for the Spectroscopic Parameters of H2O Transitions Involving High-J States

NASA Technical Reports Server (NTRS)

Ma, Q.; Tipping, R. H.; Lavrentieva, N. N.

2010-01-01

Two basic rules (i.e. the pair identity and the smooth variation) applicable for H2O transitions involving high-J states have been discovered. The origins of these rules are the properties of the energy levels and wavefunctions of H2O states with the quantum number J above certain boundaries. As a result, for lines involving high-J states in individually defined groups, all their spectroscopic parameters (i.e. the transition wavenumber, intensity, pressure-broadened half-width, pressure-induced shift, and temperature exponent) must follow these rules. One can use these rules to screen spectroscopic data provided by databases and to identify possible errors. In addition, by using extrapolation methods within the individual groups, one is able to predict the spectroscopic parameters for lines in this group involving very high-J states. The latter are required in developing high-temperature molecular spectroscopic databases such as HITEMP.

High Spatial Resolution Thermal Satellite Technologies

NASA Technical Reports Server (NTRS)

Ryan, Robert

2003-01-01

This document in the form of viewslides, reviews various low-cost alternatives to high spatial resolution thermal satellite technologies. There exists no follow-on to Landsat 7 or ASTER high spatial resolution thermal systems. This document reviews the results of the investigation in to the use of new technologies to create a low-cost useful alternative. Three suggested technologies are examined. 1. Conventional microbolometer pushbroom modes offers potential for low cost Landsat Data Continuity Mission (LDCM) thermal or ASTER capability with at least 60-120 ground sampling distance (GSD). 2. Backscanning could produce MultiSpectral Thermal Imager performance without cooled detectors. 3. Cooled detector could produce hyperspectral thermal class system or extremely high spatial resolution class instrument.

High-resolution grazing-incidence grating spectrometer for temperature measurements of low-Z ions emitting in the 100-300 Å spectral banda)

NASA Astrophysics Data System (ADS)

Widmann, K.; Beiersdorfer, P.; Magee, E. W.; Boyle, D. P.; Kaita, R.; Majeski, R.

2014-11-01

We have constructed a high-resolution grazing-incidence spectrometer designed for measuring the ion temperature of low-Z elements, such as Li+ or Li2 +, which radiate near 199 Å and 135 Å, respectively. Based on measurements at the Livermore Electron Beam Ion Trap we have shown that the instrumental resolution is better than 48 mÅ at the 200 Å setting and better than 40 mÅ for the 135-Å range. Such a high spectral resolution corresponds to an instrumental limit for line-width based temperature measurements of about 45 eV for the 199 Å Li+ and 65 eV for the 135 Å Li2 + lines. Recently obtained survey spectra from the Lithium Tokamak Experiment at the Princeton Plasma Physics Laboratory show the presence of these lithium emission lines and the expected core ion temperature of approximately 70 eV is sufficiently high to demonstrate the feasibility of utilizing our high-resolution spectrometer as an ion-temperature diagnostic.

Kinetic energy spectra, vertical resolution and dissipation in high-resolution atmospheric simulations.

NASA Astrophysics Data System (ADS)

Skamarock, W. C.

2017-12-01

We have performed week-long full-physics simulations with the MPAS global model at 15 km cell spacing using vertical mesh spacings of 800, 400, 200 and 100 meters in the mid-troposphere through the mid-stratosphere. We find that the horizontal kinetic energy spectra in the upper troposphere and stratosphere does not converge with increasing vertical resolution until we reach 200 meter level spacing. Examination of the solutions indicates that significant inertia-gravity waves are not vertically resolved at the lower vertical resolutions. Diagnostics from the simulations indicate that the primary kinetic energy dissipation results from the vertical mixing within the PBL parameterization and from the gravity-wave drag parameterization, with smaller but significant contributions from damping in the vertical transport scheme and from the horizontal filters in the dynamical core. Most of the kinetic energy dissipation in the free atmosphere occurs within breaking mid-latitude baroclinic waves. We will briefly review these results and their implications for atmospheric model configuration and for atmospheric dynamics, specifically that related to the dynamics associated with the mesoscale kinetic energy spectrum.

High-resolution computed tomography of single breast cancer microcalcifications in vivo.

PubMed

Inoue, Kazumasa; Liu, Fangbing; Hoppin, Jack; Lunsford, Elaine P; Lackas, Christian; Hesterman, Jacob; Lenkinski, Robert E; Fujii, Hirofumi; Frangioni, John V

2011-08-01

Microcalcification is a hallmark of breast cancer and a key diagnostic feature for mammography. We recently described the first robust animal model of breast cancer microcalcification. In this study, we hypothesized that high-resolution computed tomography (CT) could potentially detect the genesis of a single microcalcification in vivo and quantify its growth over time. Using a commercial CT scanner, we systematically optimized acquisition and reconstruction parameters. Two ray-tracing image reconstruction algorithms were tested: a voxel-driven "fast" cone beam algorithm (FCBA) and a detector-driven "exact" cone beam algorithm (ECBA). By optimizing acquisition and reconstruction parameters, we were able to achieve a resolution of 104 μm full width at half-maximum (FWHM). At an optimal detector sampling frequency, the ECBA provided a 28 μm (21%) FWHM improvement in resolution over the FCBA. In vitro, we were able to image a single 300 μm × 100 μm hydroxyapatite crystal. In a syngeneic rat model of breast cancer, we were able to detect the genesis of a single microcalcification in vivo and follow its growth longitudinally over weeks. Taken together, this study provides an in vivo "gold standard" for the development of calcification-specific contrast agents and a model system for studying the mechanism of breast cancer microcalcification.

High-Resolution THz Measurements of BrO Generated in AN Inductively Coupled Plasma

NASA Astrophysics Data System (ADS)

Nemchick, Deacon J.; Drouin, Brian

2017-06-01

Building upon the foundation provided by previous work, the X_{1}^{2}Π_{3/2} and X_{2}^{2}Π_{1/2} states of the transient radical, BrO, were interrogated in previously unprobed spectral regions (0.5 to 1.7 THz) by employing JPL developed high-resolution cascaded frequency multiplier sources. Like other members of the halogen monoxides (XO), this species has been the target of several recent atmospheric remote sensing studies and is a known participant in a catalytic ozone degradation cycle. For the current work, BrO is generated in an inductively coupled plasma under dynamic flow conditions and rotational lines are observed directly at their Doppler-limited resolution. New spectral transitions including those owing to both the ground (ν=0) and excited (ν=1 and 2) vibrational states of isotopologues composed of permutations of natural abundance ^{16}O, ^{18}O, ^{79}Br, and ^{81}Br are fit to a global Hamiltonian containing both fine and hyperfine terms. In addition to further refining existing spectroscopic parameters, new observations will be made available to remote detection communities through addition to the JPL catalog. New findings will be discussed along with future plans to extend these studies to other halogen monoxides (X=Cl and I) and the more massive halogen dioxides (OXO & XOO).

Development of a dual-modal tissue diagnostic system combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy.

PubMed

Sun, Yang; Park, Jesung; Stephens, Douglas N; Jo, Javier A; Sun, Lei; Cannata, Jonathan M; Saroufeem, Ramez M G; Shung, K Kirk; Marcu, Laura

2009-06-01

We report a tissue diagnostic system which combines two complementary techniques of time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonic backscatter microscopy (UBM). TR-LIFS evaluates the biochemical composition of tissue, while UBM provides tissue microanatomy and enables localization of the region of diagnostic interest. The TR-LIFS component consists of an optical fiber-based time-domain apparatus including a spectrometer, gated multichannel plate photomultiplier, and fast digitizer. It records the fluorescence with high sensitivity (nM concentration range) and time resolution as low as 300 ps. The UBM system consists of a transducer, pulser, receiving circuit, and positioning stage. The transducer used here is 45 MHz, unfocused, with axial and lateral resolutions 38 and 200 microm. Validation of the hybrid system and ultrasonic and spectroscopic data coregistration were conducted both in vitro (tissue phantom) and ex vivo (atherosclerotic tissue specimens of human aorta). Standard histopathological analysis of tissue samples was used to validate the UBM-TRLIFS data. Current results have demonstrated that spatially correlated UBM and TR-LIFS data provide complementary characterization of both morphology (necrotic core and calcium deposits) and biochemistry (collagen, elastin, and lipid features) of the atherosclerotic plaques at the same location. Thus, a combination of fluorescence spectroscopy with ultrasound imaging would allow for better identification of features associated with tissue pathologies. Current design and performance of the hybrid system suggests potential applications in clinical diagnosis of atherosclerotic plaque.

Development of a dual-modal tissue diagnostic system combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy

PubMed Central

Sun, Yang; Park, Jesung; Stephens, Douglas N.; Jo, Javier A.; Sun, Lei; Cannata, Jonathan M.; Saroufeem, Ramez M. G.; Shung, K. Kirk; Marcu, Laura

2009-01-01

We report a tissue diagnostic system which combines two complementary techniques of time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonic backscatter microscopy (UBM). TR-LIFS evaluates the biochemical composition of tissue, while UBM provides tissue microanatomy and enables localization of the region of diagnostic interest. The TR-LIFS component consists of an optical fiber-based time-domain apparatus including a spectrometer, gated multichannel plate photomultiplier, and fast digitizer. It records the fluorescence with high sensitivity (nM concentration range) and time resolution as low as 300 ps. The UBM system consists of a transducer, pulser, receiving circuit, and positioning stage. The transducer used here is 45 MHz, unfocused, with axial and lateral resolutions 38 and 200 μm. Validation of the hybrid system and ultrasonic and spectroscopic data coregistration were conducted both in vitro (tissue phantom) and ex vivo (atherosclerotic tissue specimens of human aorta). Standard histopathological analysis of tissue samples was used to validate the UBM-TRLIFS data. Current results have demonstrated that spatially correlated UBM and TR-LIFS data provide complementary characterization of both morphology (necrotic core and calcium deposits) and biochemistry (collagen, elastin, and lipid features) of the atherosclerotic plaques at the same location. Thus, a combination of fluorescence spectroscopy with ultrasound imaging would allow for better identification of features associated with tissue pathologies. Current design and performance of the hybrid system suggests potential applications in clinical diagnosis of atherosclerotic plaque. PMID:19566223

Development of a dual-modal tissue diagnostic system combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy

NASA Astrophysics Data System (ADS)

Sun, Yang; Park, Jesung; Stephens, Douglas N.; Jo, Javier A.; Sun, Lei; Cannata, Jonathan M.; Saroufeem, Ramez M. G.; Shung, K. Kirk; Marcu, Laura

2009-06-01

We report a tissue diagnostic system which combines two complementary techniques of time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonic backscatter microscopy (UBM). TR-LIFS evaluates the biochemical composition of tissue, while UBM provides tissue microanatomy and enables localization of the region of diagnostic interest. The TR-LIFS component consists of an optical fiber-based time-domain apparatus including a spectrometer, gated multichannel plate photomultiplier, and fast digitizer. It records the fluorescence with high sensitivity (nM concentration range) and time resolution as low as 300 ps. The UBM system consists of a transducer, pulser, receiving circuit, and positioning stage. The transducer used here is 45 MHz, unfocused, with axial and lateral resolutions 38 and 200 μm. Validation of the hybrid system and ultrasonic and spectroscopic data coregistration were conducted both in vitro (tissue phantom) and ex vivo (atherosclerotic tissue specimens of human aorta). Standard histopathological analysis of tissue samples was used to validate the UBM-TRLIFS data. Current results have demonstrated that spatially correlated UBM and TR-LIFS data provide complementary characterization of both morphology (necrotic core and calcium deposits) and biochemistry (collagen, elastin, and lipid features) of the atherosclerotic plaques at the same location. Thus, a combination of fluorescence spectroscopy with ultrasound imaging would allow for better identification of features associated with tissue pathologies. Current design and performance of the hybrid system suggests potential applications in clinical diagnosis of atherosclerotic plaque.

A compact imaging spectroscopic system for biomolecular detections on plasmonic chips.

PubMed

Lo, Shu-Cheng; Lin, En-Hung; Wei, Pei-Kuen; Tsai, Wan-Shao

2016-10-17

In this study, we demonstrate a compact imaging spectroscopic system for high-throughput detection of biomolecular interactions on plasmonic chips, based on a curved grating as the key element of light diffraction and light focusing. Both the curved grating and the plasmonic chips are fabricated on flexible plastic substrates using a gas-assisted thermal-embossing method. A fiber-coupled broadband light source and a camera are included in the system. Spectral resolution within 1 nm is achieved in sensing environmental index solutions and protein bindings. The detected sensitivities of the plasmonic chip are comparable with a commercial spectrometer. An extra one-dimensional scanning stage enables high-throughput detection of protein binding on a designed plasmonic chip consisting of several nanoslit arrays with different periods. The detected resonance wavelengths match well with the grating equation under an air environment. Wavelength shifts between 1 and 9 nm are detected for antigens of various concentrations binding with antibodies. A simple, mass-productive and cost-effective method has been demonstrated on the imaging spectroscopic system for real-time, label-free, highly sensitive and high-throughput screening of biomolecular interactions.

High-resolution spectroscopic observations of binary stars and yellow stragglers in three open clusters: NGC 2360, NGC 3680, and NGC 5822

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sales Silva, J. V.; Peña Suárez, V. J.; Katime Santrich, O. J.

2014-11-01

Binary stars in open clusters are very useful targets in constraining the nucleosynthesis process. The luminosities of the stars are known because the distances of the clusters are also known, so chemical peculiarities can be linked directly to the evolutionary status of a star. In addition, binary stars offer the opportunity to verify a relationship between them and the straggler population in both globular and open clusters. We carried out a detailed spectroscopic analysis to derive the atmospheric parameters for 16 red giants in binary systems and the chemical composition of 11 of them in the open clusters NGC 2360,more » NGC 3680, and NGC 5822. We obtained abundances of C, N, O, Na, Mg, Al, Ca, Si, Ti, Ni, Cr, Y, Zr, La, Ce, and Nd. The atmospheric parameters of the studied stars and their chemical abundances were determined using high-resolution optical spectroscopy. We employ the local thermodynamic equilibrium model atmospheres of Kurucz and the spectral analysis code MOOG. The abundances of the light elements were derived using the spectral synthesis technique. We found that the stars NGC 2360-92 and 96, NGC 3680-34, and NGC 5822-4 and 312 are yellow straggler stars. We show that the spectra of NGC 5822-4 and 312 present evidence of contamination by an A-type star as a secondary star. For the other yellow stragglers, evidence of contamination is given by the broad wings of the Hα. Detection of yellow straggler stars is important because the observed number can be compared with the number predicted by simulations of binary stellar evolution in open clusters. We also found that the other binary stars are not s-process enriched, which may suggest that in these binaries the secondary star is probably a faint main-sequence object. The lack of any s-process enrichment is very useful in setting constraints for the number of white dwarfs in the open cluster, a subject that is related to the birthrate of these kinds of stars in open clusters and also to the age

High spectral resolution observations of fluorescent molecular hydrogen in molecular clouds

NASA Technical Reports Server (NTRS)

Burton, Michael G.; Geballe, T. R.; Brand, P. W. J. L.; Moorhouse, A.

1990-01-01

The 1-0 S(1) line of molecular hydrogen has been observed at high spectral resolution in several sources where the emission was suspected of being fluorescent. In NGC 2023, the Orion Bar, and Parsamyan 18, the S(1) line is unresolved, and the line center close to the rest velocity of the ambient molecular cloud. Such behavior is expected for UV-excited line emission. The H2 line widths in molecular clouds thus can serve as diagnostic for shocked and UV-excitation mechanisms. If the lines are broader than several km/s or velocity shifts are observed across a source it is likely that shocks are responsible for the excitation of the gas.

Analysis of Atmospheric Trace Constituents from High Resolution Infrared Balloon-Borne and Ground-Based Solar Absorption Spectra

NASA Technical Reports Server (NTRS)

Goldman, A.; Murcray, F. J.; Rinsland, C. P.; Blatherwick, R. D.; Murcray, F. H.; Murcray, D. G.

1991-01-01

Recent results and ongoing studies of high resolution solar absorption spectra will be presented. The analysis of these spectra is aimed at the identification and quantification of trace constituents important in atmospheric chemistry of the stratosphere and upper troposphere. Analysis of balloon-borne and ground-based spectra obtained at 0.0025/ cm covering the 700-2200/ cm interval will be presented. Results from ground-based 0.02/ cm solar spectra, from several locations such as Denver, South Pole, M. Loa, and New Zealand will also be shown. The 0.0025/ cm spectra show many new spectroscopic features. The analysis of these spectra, along with corresponding laboratory spectra, improves the spectral line parameters, and thus the accuracy of trace constituents quantification. The combination of the recent balloon flights, with earlier flights data since 1978 at 0.02/ cm resolution, provides trends analysis of several stratospheric trace species. Results for COF2, F22, SF6, and other species will be presented. Analysis of several ground-based solar spectra provides trends for HCl, HF and other species. The retrieval methods used for total column density and altitude distribution for both ground-based and balloon-borne spectra will be presented. These are extended for the analysis of the ground-based spectra to be obtained by the high resolution interferometers of the Network for Detection of Stratospheric Change (NDSC). Progress or the University of Denver studies for the NDSC will be presented. This will include intercomparison of solar spectra and trace gases retrievals obtained from simultaneous scans by the high resolution (0.0025/ cm) interferometers of BRUKER and BOMEM.

Ultra-high resolution coded wavefront sensor.

PubMed

Wang, Congli; Dun, Xiong; Fu, Qiang; Heidrich, Wolfgang

2017-06-12

Wavefront sensors and more general phase retrieval methods have recently attracted a lot of attention in a host of application domains, ranging from astronomy to scientific imaging and microscopy. In this paper, we introduce a new class of sensor, the Coded Wavefront Sensor, which provides high spatio-temporal resolution using a simple masked sensor under white light illumination. Specifically, we demonstrate megapixel spatial resolution and phase accuracy better than 0.1 wavelengths at reconstruction rates of 50 Hz or more, thus opening up many new applications from high-resolution adaptive optics to real-time phase retrieval in microscopy.

High-Resolution Infrared Imaging and Polarimetry plus Spectroscopy of Evolved Red and Yellow Supergiants

NASA Astrophysics Data System (ADS)

Gordon, Michael Scott; Humphreys, Roberta; Jones, Terry J.; Gehrz, Robert D.

2018-01-01

To what extent mass loss and periods of enhanced stellar outflow can influence the terminal state of the most massive stars remains an outstanding question in the fields of stellar physics, chemical enrichment of the Local Universe, andsupernova research. For my dissertation, I focus on characterizing the stellar ejecta around supergiants through a combination of observing techniques. Using the LBT, MMT, IRTF, VLT, and SOFIA observatories, I have performed high-resolution imaging, spectroscopy, and polarimetry—methods that provide us with keen insight on mass-loss histories and 3D morphology of the Local Group's most fascinating stars.Based on spectroscopic evidence for mass loss in the optical and the presence ofcircumstellar (CS) dust in infrared SEDs, we find that 30%–40% of observed yellow supergiants in M31 and M33 are likely in a post-RSG state. We also presentnear-IR spectra from IRTF/SPeX of optically-obscured RSGs in M33. These IR-bright sources likely have some of the highest mass-loss rates and are self-obscured in the optical by their own CS ejecta. For Galactic red supergiants (RSGs), we are able to observe the gas and CS dust ejecta both close in to the central star and at larger distances. The resulting radial profiles are valuable probes on timescale for the ejecta when combined with radiative-transfer models. We find evidence for both variable/high mass-loss events and constant mass loss over the last few thousand years. Finally, we discuss the use of high-resolution imaging polarimetry with VLT/NACO of two co-eval RSG clusters toward the Galactic center. The resulting polarized intensity images in the near-infrared provide unprecedented spatial and contrast resolution of the scattered light from extended nebular material.

Layout and results from the initial operation of the high-resolution x-ray imaging crystal spectrometer on the Large Helical Device.

PubMed

Pablant, N A; Bitter, M; Delgado-Aparicio, L; Goto, M; Hill, K W; Lazerson, S; Morita, S; Roquemore, A L; Gates, D; Monticello, D; Nielson, H; Reiman, A; Reinke, M; Rice, J E; Yamada, H

2012-08-01

First results of ion and electron temperature profile measurements from the x-ray imaging crystal spectrometer (XICS) diagnostic on the Large Helical Device (LHD) are presented. This diagnostic system has been operational since the beginning of the 2011 LHD experimental campaign and is the first application of the XICS diagnostic technique to helical plasma geometry. The XICS diagnostic provides measurements of ion and electron temperature profiles in LHD with a spatial resolution of 2 cm and a maximum time resolution of 5 ms (typically 20 ms). Ion temperature profiles from the XICS diagnostic are possible under conditions where charge exchange recombination spectroscopy (CXRS) is not possible (high density) or is perturbative to the plasma (low density or radio frequency heated plasmas). Measurements are made by using a spherically bent crystal to provide a spectrally resolved 1D image of the plasma from line integrated emission of helium-like Ar(16 +). The final hardware design and configuration are detailed along with the calibration procedures. Line-integrated ion and electron temperature measurements are presented, and the measurement accuracy is discussed. Finally central temperature measurements from the XICS system are compared to measurements from the Thomson scattering and CXRS systems, showing excellent agreement.

High-resolution Spectroscopic Abundances of Red Giant Branch Stars in NGC 6584 and NGC 7099

NASA Astrophysics Data System (ADS)

O’Malley, Erin M.; Chaboyer, Brian

2018-04-01

We obtain high-resolution spectra of red giant branch stars in NGC 6584 and NGC 7099 to perform a detailed abundance analysis. We confirm cluster membership for these stars based on consistent radial velocities measured in this study and small pixel offsets between the observations of Sarajedini et al. and Piotto et al. We find mean metallicities of [Fe/H] = ‑1.53 ± 0.08 dex and [Fe/H] = ‑2.29 ± 0.07 dex for NGC 6584 and NGC 7099, respectively. We also find these clusters to be enhanced in their [α/Fe] ratios, consistent with what is expected for metal-poor globular clusters. Additionally, we find evidence of a statistically significant Na–O anti-correlation in both clusters. Finally, with the use of HST photometry, we compare the location of the enhanced and pristine populations in chromosome maps of the clusters to confirm previous photometric evidence of multiple stellar populations. Although we cannot confirm the nature of the polluter stars responsible for the abundance differences, our results can be used to constrain pollution models.

Proposal of AAA-battery-size one-shot ATR Fourier spectroscopic imager for on-site analysis: Simultaneous measurement of multi-components with high accuracy

NASA Astrophysics Data System (ADS)

Hosono, Satsuki; Qi, Wei; Sato, Shun; Suzuki, Yo; Fujiwara, Masaru; Hiramatsu, Hiroyuki; Suzuki, Satoru; Abeygunawardhana, P. K. W.; Wada, Kenji; Nishiyama, Akira; Ishimaru, Ichiro

2015-03-01

For simultaneous measurement of multi-components on-site like factories, the ultra-compact (diameter: 9[mm], length: 45[mm], weight: 200[g]) one-shot ATR (Attenuated Total Reflection) Fourier spectroscopic imager was proposed. Because the proposed one-shot Fourier spectroscopic imaging is based on spatial-phase-shift interferometer, interferograms could be obtained with simple optical configurations. We introduced the transmission-type relativeinclined phase-shifter, that was constructed with a cuboid prism and a wedge prism, onto the optical Fourier transform plane of infinity corrected optical systems. And also, small light-sources and cameras in the mid-infrared light region, whose size are several millimeter on a side, are essential components for the ultra-compact spectroscopic configuration. We selected the Graphite light source (light source area: 1.7×1.7[mm], maker: Hawkeye technologies) whose radiation factor was high. Fortunately, in these days we could apply the cost-effective 2-dimensional light receiving device for smartphone (e.g. product name: LEPTON, maker: FLIR, price: around 400USD). In the case of alcoholic drinks factory, conventionally workers measure glucose and ethanol concentrations by bringing liquid solution back to laboratories every day. The high portable spectroscopy will make it possible to measure multi-components simultaneously on manufacturing scene. But we found experimentally that absorption spectrum of glucose and water and ethanol were overlapped each other in near infrared light region. But for mid-infrared light region, we could distinguish specific absorption peaks of glucose (@10.5[μm]) and ethanol (@11.5[μm]) independently from water absorption. We obtained standard curve between absorption (@9.6[μm]) and ethanol concentration with high correlation coefficient 0.98 successfully by ATR imaging-type 2-dimensional Fourier spectroscopy (wavelength resolution: 0.057[μm]) with the graphite light source (maker: Hawkeye

Optical frequency comb Fourier transform spectroscopy with sub-nominal resolution and precision beyond the Voigt profile

NASA Astrophysics Data System (ADS)

Rutkowski, Lucile; Masłowski, Piotr; Johansson, Alexandra C.; Khodabakhsh, Amir; Foltynowicz, Aleksandra

2018-01-01

Broadband precision spectroscopy is indispensable for providing high fidelity molecular parameters for spectroscopic databases. We have recently shown that mechanical Fourier transform spectrometers based on optical frequency combs can measure broadband high-resolution molecular spectra undistorted by the instrumental line shape (ILS) and with a highly precise frequency scale provided by the comb. The accurate measurement of the power of the comb modes interacting with the molecular sample was achieved by acquiring single-burst interferograms with nominal resolution matched to the comb mode spacing. Here we describe in detail the experimental and numerical steps needed to achieve sub-nominal resolution and retrieve ILS-free molecular spectra, i.e. with ILS-induced distortion below the noise level. We investigate the accuracy of the transition line centers retrieved by fitting to the absorption lines measured using this method. We verify the performance by measuring an ILS-free cavity-enhanced low-pressure spectrum of the 3ν1 + ν3 band of CO2 around 1575 nm with line widths narrower than the nominal resolution. We observe and quantify collisional narrowing of absorption line shape, for the first time with a comb-based spectroscopic technique. Thus retrieval of line shape parameters with accuracy not limited by the Voigt profile is now possible for entire absorption bands acquired simultaneously.

Error tolerance analysis of wave diagnostic based on coherent modulation imaging in high power laser system

NASA Astrophysics Data System (ADS)

Pan, Xingchen; Liu, Cheng; Zhu, Jianqiang

2018-02-01

Coherent modulation imaging providing fast convergence speed and high resolution with single diffraction pattern is a promising technique to satisfy the urgent demands for on-line multiple parameter diagnostics with single setup in high power laser facilities (HPLF). However, the influence of noise on the final calculated parameters concerned has not been investigated yet. According to a series of simulations with twenty different sampling beams generated based on the practical parameters and performance of HPLF, the quantitative analysis based on statistical results was first investigated after considering five different error sources. We found the background noise of detector and high quantization error will seriously affect the final accuracy and different parameters have different sensitivity to different noise sources. The simulation results and the corresponding analysis provide the potential directions to further improve the final accuracy of parameter diagnostics which is critically important to its formal applications in the daily routines of HPLF.

Development of Compton X-ray spectrometer for high energy resolution single-shot high-flux hard X-ray spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kojima, Sadaoki, E-mail: kojima-s@ile.osaka-u.ac.jp, E-mail: sfujioka@ile.osaka-u.ac.jp; Ikenouchi, Takahito; Arikawa, Yasunobu

Hard X-ray spectroscopy is an essential diagnostics used to understand physical processes that take place in high energy density plasmas produced by intense laser-plasma interactions. A bundle of hard X-ray detectors, of which the responses have different energy thresholds, is used as a conventional single-shot spectrometer for high-flux (>10{sup 13} photons/shot) hard X-rays. However, high energy resolution (Δhv/hv < 0.1) is not achievable with a differential energy threshold (DET) X-ray spectrometer because its energy resolution is limited by energy differences between the response thresholds. Experimental demonstration of a Compton X-ray spectrometer has already been performed for obtaining higher energy resolutionmore » than that of DET spectrometers. In this paper, we describe design details of the Compton X-ray spectrometer, especially dependence of energy resolution and absolute response on photon-electron converter design and its background reduction scheme, and also its application to the laser-plasma interaction experiment. The developed spectrometer was used for spectroscopy of bremsstrahlung X-rays generated by intense laser-plasma interactions using a 200 μm thickness SiO{sub 2} converter. The X-ray spectrum obtained with the Compton X-ray spectrometer is consistent with that obtained with a DET X-ray spectrometer, furthermore higher certainly of a spectral intensity is obtained with the Compton X-ray spectrometer than that with the DET X-ray spectrometer in the photon energy range above 5 MeV.« less

Novel Strategy to Evaluate Infectious Salmon Anemia Virus Variants by High Resolution Melting

PubMed Central

Sepúlveda, Dagoberto; Cárdenas, Constanza; Carmona, Marisela; Marshall, Sergio H.

2012-01-01

Genetic variability is a key problem in the prevention and therapy of RNA-based virus infections. Infectious Salmon Anemia virus (ISAv) is an RNA virus which aggressively attacks salmon producing farms worldwide and in particular in Chile. Just as with most of the Orthomyxovirus, ISAv displays high variability in its genome which is reflected by a wider infection potential, thus hampering management and prevention of the disease. Although a number of widely validated detection procedures exist, in this case there is a need of a more complex approach to the characterization of virus variability. We have adapted a procedure of High Resolution Melting (HRM) as a fine-tuning technique to fully differentiate viral variants detected in Chile and projected to other infective variants reported elsewhere. Out of the eight viral coding segments, the technique was adapted using natural Chilean variants for two of them, namely segments 5 and 6, recognized as virulence-associated factors. Our work demonstrates the versatility of the technique as well as its superior resolution capacity compared with standard techniques currently in use as key diagnostic tools. PMID:22719837

Enhanced High Resolution RBS System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pollock, Thomas J.; Hass, James A.; Klody, George M.

2011-06-01

Improvements in full spectrum resolution with the second NEC high resolution RBS system are summarized. Results for 50 A ring TiN/HfO films on Si yielding energy resolution on the order of 1 keV are also presented. Detector enhancements include improved pulse processing electronics, upgraded shielding for the MCP/RAE detector, and reduced noise generated from pumping. Energy resolution measurements on spectra front edge coupled with calculations using 0.4mStr solid angle show that beam energy spread at 400 KeV from the Pelletron registered accelerator is less than 100 eV. To improve user throughput, magnet control has been added to the automatic datamore » collection. Depth profiles derived from experimental data are discussed. For the thin films profiled, depth resolutions were on the Angstrom level with the non-linear energy/channel conversions ranging from 100 to 200 eV.« less

Patient Navigation and Time to Diagnostic Resolution: Results for a Cluster Randomized Trial Evaluating the Efficacy of Patient Navigation among Patients with Breast Cancer Screening Abnormalities, Tampa, FL

PubMed Central

Lee, Ji-Hyun; Fulp, William; Wells, Kristen J.; Meade, Cathy D.; Calcano, Ercilia; Roetzheim, Richard

2013-01-01

Objectives The objective of this study was to evaluate a patient navigation (PN) program that attempts to reduce the time between a breast cancer screening abnormality and definitive diagnosis among medically underserved populations of Tampa Bay, Florida. Methods The Moffitt Patient Navigation Research Program conducted a cluster randomized design with 10 primary care clinics. Patients were navigated from time of a breast screening abnormality to diagnostic resolution. This paper examined the length of time between breast abnormality and definitive diagnosis, using a shared frailty Cox proportional hazard model to assess PN program effect. Results 1,039 patients were eligible for the study because of an abnormal breast cancer screening/clinical abnormality (494 navigated; 545 control). Analysis of PN effect by two time periods of resolution (0-3 months and > 3 months) showed a lagged effect of PN. For patients resolving in the first three months, the adjusted Hazard Ratio (aHR) was 0.85 (95% Confidence Interval [CI]: 0.64-1.13) suggesting that PN had no effect on resolution time during this period. Beyond three months, however, navigated patients resolved more quickly to diagnostic resolution compared with the control group (aHR 2.8, 95%CI: 1.30-6.13). The predicted aHR at 3 months was 1.2, which was not statistically significant, while PN had a significant positive effect beyond 4.7 months. Conclusions PN programs may increase the timeliness of diagnostic resolution for patients with a breast cancer-related abnormality. PN did not speed diagnostic resolution during the initial three months of follow up but started to reduce time to diagnostic resolution after three months and showed a significant effect after 4.7 months. Trial Registration ClinicalTrials.gov NCT00375024 PMID:24066145

Patient navigation and time to diagnostic resolution: results for a cluster randomized trial evaluating the efficacy of patient navigation among patients with breast cancer screening abnormalities, Tampa, FL.

PubMed

Lee, Ji-Hyun; Fulp, William; Wells, Kristen J; Meade, Cathy D; Calcano, Ercilia; Roetzheim, Richard

2013-01-01

The objective of this study was to evaluate a patient navigation (PN) program that attempts to reduce the time between a breast cancer screening abnormality and definitive diagnosis among medically underserved populations of Tampa Bay, Florida. The Moffitt Patient Navigation Research Program conducted a cluster randomized design with 10 primary care clinics. Patients were navigated from time of a breast screening abnormality to diagnostic resolution. This paper examined the length of time between breast abnormality and definitive diagnosis, using a shared frailty Cox proportional hazard model to assess PN program effect. 1,039 patients were eligible for the study because of an abnormal breast cancer screening/clinical abnormality (494 navigated; 545 control). Analysis of PN effect by two time periods of resolution (0-3 months and > 3 months) showed a lagged effect of PN. For patients resolving in the first three months, the adjusted Hazard Ratio (aHR) was 0.85 (95% Confidence Interval [CI]: 0.64-1.13) suggesting that PN had no effect on resolution time during this period. Beyond three months, however, navigated patients resolved more quickly to diagnostic resolution compared with the control group (aHR 2.8, 95%CI: 1.30-6.13). The predicted aHR at 3 months was 1.2, which was not statistically significant, while PN had a significant positive effect beyond 4.7 months. PN programs may increase the timeliness of diagnostic resolution for patients with a breast cancer-related abnormality. PN did not speed diagnostic resolution during the initial three months of follow up but started to reduce time to diagnostic resolution after three months and showed a significant effect after 4.7 months. ClinicalTrials.gov NCT00375024.

Evaluation of resolution and periodic errors of a flatbed scanner used for digitizing spectroscopic photographic plates

PubMed Central

Wyatt, Madison; Nave, Gillian

2017-01-01

We evaluated the use of a commercial flatbed scanner for digitizing photographic plates used for spectroscopy. The scanner has a bed size of 420 mm by 310 mm and a pixel size of about 0.0106 mm. Our tests show that the closest line pairs that can be resolved with the scanner are 0.024 mm apart, only slightly larger than the Nyquist resolution of 0.021 mm expected by the 0.0106 mm pixel size. We measured periodic errors in the scanner using both a calibrated length scale and a photographic plate. We find no noticeable periodic errors in the direction parallel to the linear detector in the scanner, but errors with an amplitude of 0.03 mm to 0.05 mm in the direction perpendicular to the detector. We conclude that large periodic errors in measurements of spectroscopic plates using flatbed scanners can be eliminated by scanning the plates with the dispersion direction parallel to the linear detector by placing the plate along the short side of the scanner. PMID:28463262

High resolution data acquisition

DOEpatents

Thornton, G.W.; Fuller, K.R.

1993-04-06

A high resolution event interval timing system measures short time intervals such as occur in high energy physics or laser ranging. Timing is provided from a clock, pulse train, and analog circuitry for generating a triangular wave synchronously with the pulse train (as seen in diagram on patent). The triangular wave has an amplitude and slope functionally related to the time elapsed during each clock pulse in the train. A converter forms a first digital value of the amplitude and slope of the triangle wave at the start of the event interval and a second digital value of the amplitude and slope of the triangle wave at the end of the event interval. A counter counts the clock pulse train during the interval to form a gross event interval time. A computer then combines the gross event interval time and the first and second digital values to output a high resolution value for the event interval.

High resolution data acquisition

DOEpatents

Thornton, Glenn W.; Fuller, Kenneth R.

1993-01-01

A high resolution event interval timing system measures short time intervals such as occur in high energy physics or laser ranging. Timing is provided from a clock (38) pulse train (37) and analog circuitry (44) for generating a triangular wave (46) synchronously with the pulse train (37). The triangular wave (46) has an amplitude and slope functionally related to the time elapsed during each clock pulse in the train. A converter (18, 32) forms a first digital value of the amplitude and slope of the triangle wave at the start of the event interval and a second digital value of the amplitude and slope of the triangle wave at the end of the event interval. A counter (26) counts the clock pulse train (37) during the interval to form a gross event interval time. A computer (52) then combines the gross event interval time and the first and second digital values to output a high resolution value for the event interval.

[Clinical processes in a high resolution clinic of specialist outpatient clinics].

PubMed

Zambrana-García, J L; Torres-Jiménez, M; Rubio-Sánchez, J M; Montijano-Cabrera, A; Peña-Ojeda, J A; Velasco-Malagón, M J

The high resolution clinic (HRC) is an outpatient care process by which treatment and diagnosis are established, recorded, and completed in a single day. The aim of this study was to assess the extent to which patients with medical conditions may benefit from a single consultation system. A descriptive study of 795 first visit events, randomly selected as high-resolution consultations in cardiology, gastroenterology, internal medicine, and chest diseases. A discussion is presented on the percentage of patients who benefited from HRC and the complementary tests performed. A total of 559 (70%, 95% CI: 67-73%) of all first visits became HRCs, and 483 (61%, 95% CI: 57%-64%) required a diagnostic test that was reviewed on the same day. There were differences between medical consultations (86% in cardiology versus 44% in gastroenterology consultations, P<.001). Performing a test on the same day significantly increased the percentage of HRCs (49 versus 22%, P<.001). Ischaemic heart disease, dyspepsia, headache, and asthma were the conditions most commonly leading to HRC. The most common tests were cranial tomography, blood analysis, and ultrasound. Medical consultations may largely benefit from an HRC system, only requiring some organisational changes and no additional costs. Copyright © 2016 SECA. Publicado por Elsevier España, S.L.U. All rights reserved.

High-Resolution Infrared Spectroscopy of Carbon-Sulfur Chains: II. C_5S and SC_5S

NASA Astrophysics Data System (ADS)

Thorwirth, Sven; Salomon, Thomas; Dudek, John B.

2016-06-01

Unbiased high-resolution infrared survey scans of the ablation products from carbon-sulfur targets in the 2100 to 2150 cm-1 regime reveal two bands previously not observed in the gas phase. On the basis of comparison against laboratory matrix-isolation work and new high-level quantum-chemical calculations these bands are attributed to the linear C_5S and SC_5S clusters. While polar C_5S was studied earlier using Fourier-transform microwave techniques, the present work marks the first gas-phase spectroscopic detection of SC_5S. H. Wang, J. Szczepanski, P. Brucat, and M. Vala 2005, Int. J. Quant. Chem. 102, 795 Y. Kasai, K. Obi, Y. Ohshima, Y. Hirahara, Y. Endo, K. Kawaguchi, and A. Murakami 1993, ApJ 410, L45 V. D. Gordon, M. C. McCarthy, A. J. Apponi, and P. Thaddeus 2001, ApJS 134, 311

High-resolution spectroscopic observations of the new CEMP-s star CD -50°776

NASA Astrophysics Data System (ADS)

Roriz, M.; Pereira, C. B.; Drake, N. A.; Roig, F.; Silva, J. V. Sales

2017-11-01

Carbon enhanced metal-poor (CEMP) stars are a particular class of low-metalicity halo stars whose chemical analysis may provide important contrains to the chemistry evolution of the Galaxy and to the models of mass-transfer and evolution of components in binary systems. Here, we present a detailed analysis of the CEMP star CD -50°776, using high resolution optical spectroscopy. We found that CD -50°776 has a metalicity [Fe/H] = -2.31 and a carbon abundance [C/Fe] = +1.21. Analysing the s-process elements and the europium abundances, we show that this star is actually a CEMP-s star, based on the criteria set in the literature to classify these chemically peculiar objects. We also show that CD -50°776 is a lead star, since it has a ratio [Pb/Ce] = +0.97. In addition, we show that CD -50°776 develops radial velocity variations that may be attributed to the orbital motion in a binary system. The abundance pattern of CD -50°776 is discussed and compared to other CEMP-s stars already reported in the literature to show that this star is a quite exceptional object among the CEMP stars, particularly due to its low nitrogen abundance. Explaining this pattern may require to improve the nucleosynthesis models, and the evolutionary models of mass transfer and binary interaction.

Diagnostic evaluations of microwave generated helium and nitrogen plasma mixtures

NASA Technical Reports Server (NTRS)

Haraburda, Scott S.; Hawley, Martin C.; Dinkel, Duane W.

1990-01-01

The goal of this work is to continue the development to fundamentally understand the plasma processes as applied to spacecraft propulsion. The diagnostic experiments used are calorimetric, dimensional, and spectroscopic measurements using the TM 011 and TM 012 modes in the resonance cavity. These experimental techniques are highly important in furthering the understanding of plasma phenomena and of designing rocket thrusters. Several experimental results are included using nitrogen and helium gas mixtures.

Abundances of disk and bulge giants from high-resolution optical spectra. I. O, Mg, Ca, and Ti in the solar neighborhood and Kepler field samples

NASA Astrophysics Data System (ADS)

Jönsson, H.; Ryde, N.; Nordlander, T.; Pehlivan Rhodin, A.; Hartman, H.; Jönsson, P.; Eriksson, K.

2017-02-01

Context. The Galactic bulge is an intriguing and significant part of our Galaxy, but it is hard to observe because it is both distant and covered by dust in the disk. Therefore, there are not many high-resolution optical spectra of bulge stars with large wavelength coverage, whose determined abundances can be compared with nearby, similarly analyzed stellar samples. Aims: We aim to determine the diagnostically important alpha elements of a sample of bulge giants using high-resolution optical spectra with large wavelength coverage. The abundances found are compared to similarly derived abundances from similar spectra of similar stars in the local thin and thick disks. In this first paper we focus on the solar neighborhood reference sample. Methods: We used spectral synthesis to derive the stellar parameters as well as the elemental abundances of both the local and bulge samples of giants. We took special care to benchmark our method of determining stellar parameters against independent measurements of effective temperatures from angular diameter measurements and surface gravities from asteroseismology. Results: In this first paper we present the method used to determine the stellar parameters and elemental abundances, evaluate them, and present the results for our local disk sample of 291 giants. Conclusions: When comparing our determined spectroscopic temperatures to those derived from angular diameter measurements, we reproduce these with a systematic difference of +10 K and a standard deviation of 53 K. The spectroscopic gravities reproduce those determined from asteroseismology with a systematic offset of +0.10 dex and a standard deviation of 0.12 dex. When it comes to the abundance trends, our sample of local disk giants closely follows trends found in other works analyzing solar neighborhood dwarfs, showing that the much brighter giant stars are as good abundance probes as the often used dwarfs. Based on observations made with the Nordic Optical Telescope

CHISL: the combined high-resolution and imaging spectrograph for the LUVOIR surveyor

NASA Astrophysics Data System (ADS)

France, Kevin; Fleming, Brian; Hoadley, Keri

2016-07-01

NASA is currently carrying out science and technical studies to identify its next astronomy flagship mission, slated to begin development in the 2020s. It has become clear that a Large Ultraviolet/Optical/IR (LUVOIR) Surveyor mission (dprimary ≍ 12 m, Δλ ≍ 1000 Å - 2 μm spectroscopic bandpass) can carry out the largest number of NASA's exoplanet and astrophysics science goals over the coming decades. The science grasp of a LUVOIR Surveyor is broad, ranging from the direct detection of potential biomarkers on rocky planets to the flow of matter into and out of galaxies and the history of star-formation across cosmic time. There are technical challenges for several aspects of the LUVOIR Surveyor concept, including component level technology readiness maturation and science instrument concepts for a broadly capable ultraviolet spectrograph. We present the scientific motivation for, and a preliminary design of, a multiplexed ultraviolet spectrograph to support both the exoplanet and astrophysics goals of the LUVOIR Surveyor mission concept, the Combined High-resolution and Imaging Spectrograph for the LUVOIR Surveyor (CHISL). CHISL includes a highresolution (R ≍ 120,000; 1000 - 1700Å) point-source spectroscopy channel and a medium resolution (R >= 14,000 from 1000 - 2000 Å in a single observation and R 24,000 - 35,000 in multiple grating settings) imaging spectroscopy channel. CHISL addresses topics ranging from characterizing the composition and structure of planet-forming disks to the feedback of matter between galaxies and the intergalactic medium. We present the CHISL concept, a small sample of representative science cases, and the primary technological hurdles. Technical challenges include high-efficiency ultraviolet coatings and high-quantum efficiency, large-format, photon counting detectors. We are actively engaged in laboratory and flight characterization efforts for all of these enabling technologies as components on sounding rocket payloads under

High resolution surface plasmon microscopy for cell imaging

NASA Astrophysics Data System (ADS)

Argoul, F.; Monier, K.; Roland, T.; Elezgaray, J.; Berguiga, L.

2010-04-01

We introduce a new non-labeling high resolution microscopy method for cellular imaging. This method called SSPM (Scanning Surface Plasmon Microscopy) pushes down the resolution limit of surface plasmon resonance imaging (SPRi) to sub-micronic scales. High resolution SPRi is obtained by the surface plasmon lauching with a high numerical aperture objective lens. The advantages of SPPM compared to other high resolution SPRi's rely on three aspects; (i) the interferometric detection of the back reflected light after plasmon excitation, (ii) the twodimensional scanning of the sample for image reconstruction, (iii) the radial polarization of light, enhancing both resolution and sensitivity. This microscope can afford a lateral resolution of - 150 nm in liquid environment and - 200 nm in air. We present in this paper images of IMR90 fibroblasts obtained with SSPM in dried environment. Internal compartments such as nucleus, nucleolus, mitochondria, cellular and nuclear membrane can be recognized without labelling. We propose an interpretation of the ability of SSPM to reveal high index contrast zones by a local decomposition of the V (Z) function describing the response of the SSPM.

High-Pressure Gaseous Burner (HPGB) Facility Completed for Quantitative Laser Diagnostics Calibration

NASA Technical Reports Server (NTRS)

Nguyen, Quang-Viet

2002-01-01

A gas-fueled high-pressure combustion facility with optical access, which was developed over the last 2 years, has just been completed. The High Pressure Gaseous Burner (HPGB) rig at the NASA Glenn Research Center can operate at sustained pressures up to 60 atm with a variety of gaseous fuels and liquid jet fuel. The facility is unique as it is the only continuous-flow, hydrogen-capable, 60-atm rig in the world with optical access. It will provide researchers with new insights into flame conditions that simulate the environment inside the ultra-high-pressure-ratio combustion chambers of tomorrow's advanced aircraft engines. The facility provides optical access to the flame zone, enabling the calibration of nonintrusive optical diagnostics to measure chemical species and temperature. The data from the HPGB rig enables the validation of numerical codes that simulate gas turbine combustors, such as the National Combustor Code (NCC). The validation of such numerical codes is often best achieved with nonintrusive optical diagnostic techniques that meet these goals: information-rich (multispecies) and quantitative while providing good spatial and time resolution. Achieving these goals is a challenge for most nonintrusive optical diagnostic techniques. Raman scattering is a technique that meets these challenges. Raman scattering occurs when intense laser light interacts with molecules to radiate light at a shifted wavelength (known as the Raman shift). This shift in wavelength is unique to each chemical species and provides a "fingerprint" of the different species present. The facility will first be used to gather a comprehensive data base of laser Raman spectra at high pressures. These calibration data will then be used to quantify future laser Raman measurements of chemical species concentration and temperature in this facility and other facilities that use Raman scattering.

Thermal imaging diagnostics of high-current electron beams.

PubMed

Pushkarev, A; Kholodnaya, G; Sazonov, R; Ponomarev, D

2012-10-01

The thermal imaging diagnostics of measuring pulsed electron beam energy density is presented. It provides control of the electron energy spectrum and a measure of the density distribution of the electron beam cross section, the spatial distribution of electrons with energies in the selected range, and the total energy of the electron beam. The diagnostics is based on the thermal imager registration of the imaging electron beam thermal print in a material with low bulk density and low thermal conductivity. Testing of the thermal imaging diagnostics has been conducted on a pulsed electron accelerator TEU-500. The energy of the electrons was 300-500 keV, the density of the electron current was 0.1-0.4 kA/cm(2), the duration of the pulse (at half-height) was 60 ns, and the energy in the pulse was up to 100 J. To register the thermal print, a thermal imager Fluke-Ti10 was used. Testing showed that the sensitivity of a typical thermal imager provides the registration of a pulsed electron beam heat pattern within one pulse with energy density over 0.1 J/cm(2) (or with current density over 10 A/cm(2), pulse duration of 60 ns and electron energy of 400 keV) with the spatial resolution of 0.9-1 mm. In contrast to the method of using radiosensitive (dosimetric) materials, thermal imaging diagnostics does not require either expensive consumables, or plenty of processing time.

Neurologic 3D MR Spectroscopic Imaging with Low-Power Adiabatic Pulses and Fast Spiral Acquisition

PubMed Central

Gagoski, Borjan A.; Sorensen, A. Gregory

2012-01-01

Purpose: To improve clinical three-dimensional (3D) MR spectroscopic imaging with more accurate localization and faster acquisition schemes. Materials and Methods: Institutional review board approval and patient informed consent were obtained. Data were acquired with a 3-T MR imager and a 32-channel head coil in phantoms, five healthy volunteers, and five patients with glioblastoma. Excitation was performed with localized adiabatic spin-echo refocusing (LASER) by using adiabatic gradient-offset independent adiabaticity wideband uniform rate and smooth truncation (GOIA-W[16,4]) pulses with 3.5-msec duration, 20-kHz bandwidth, 0.81-kHz amplitude, and 45-msec echo time. Interleaved constant-density spirals simultaneously encoded one frequency and two spatial dimensions. Conventional phase encoding (PE) (1-cm3 voxels) was performed after LASER excitation and was the reference standard. Spectra acquired with spiral encoding at similar and higher spatial resolution and with shorter imaging time were compared with those acquired with PE. Metabolite levels were fitted with software, and Bland-Altman analysis was performed. Results: Clinical 3D MR spectroscopic images were acquired four times faster with spiral protocols than with the elliptical PE protocol at low spatial resolution (1 cm3). Higher-spatial-resolution images (0.39 cm3) were acquired twice as fast with spiral protocols compared with the low-spatial-resolution elliptical PE protocol. A minimum signal-to-noise ratio (SNR) of 5 was obtained with spiral protocols under these conditions and was considered clinically adequate to reliably distinguish metabolites from noise. The apparent SNR loss was not linear with decreasing voxel sizes because of longer local T2* times. Improvement of spectral line width from 4.8 Hz to 3.5 Hz was observed at high spatial resolution. The Bland-Altman agreement between spiral and PE data is characterized by narrow 95% confidence intervals for their differences (0.12, 0.18 of their

Progress Toward Modeling Spectroscopic Signatures of Mix on Omega and NIF

NASA Astrophysics Data System (ADS)

Tregillis, I. L.; Schmitt, M. J.; Hsu, S. C.; Wysocki, F. J.; Cobble, J. A.; Murphy, T. J.

2011-10-01

Defect-induced mix processes may degrade the performance of ICF and ICF-like targets at Omega and NIF. An improved understanding of the relevant physics requires an experimental program built on a foundation of radiation-hydrodynamic simulations plus reliable synthetic diagnostic outputs. To that end, the Applications of Ignition (AoI) and Defect Implosion Experiment (DIME) efforts at LANL have focused on directly driven plastic capsules containing high-Z dopants and manufactured with an equatorial ``trench'' defect. One of the key diagnostic techniques for detecting and diagnosing the migration of dopant material into the hot core is Multi-Monochromatic X-ray Imaging (MMI). This talk will focus on recent efforts to model spectroscopic signatures of mix processes in AoI/DIME capsules via simulated MMI-type diagnostic instruments. It will also include data from recent Omega shots and calculations in support of Tier 1 experiments at NIF in FY2012. This work is supported by US DOE/NNSA, performed at LANL, operated by LANS LLC under contract DE-AC52-06NA25396.

Using High Spatial Resolution Digital Imagery

DTIC Science & Technology

2005-02-01

digital base maps were high resolution U.S. Geological Survey (USGS) Digital Orthophoto Quarter Quadrangles (DOQQ). The Root Mean Square Errors (RMSE...next step was to assign real world coordinates to the linear im- age. The mosaics were geometrically registered to the panchromatic orthophotos ...useable thematic map from high-resolution imagery. A more practical approach may be to divide the Refuge into a set of smaller areas, or tiles

Rapid, scalable and highly automated HLA genotyping using next-generation sequencing: a transition from research to diagnostics

PubMed Central

2013-01-01

Background Human leukocyte antigen matching at allelic resolution is proven clinically significant in hematopoietic stem cell transplantation, lowering the risk of graft-versus-host disease and mortality. However, due to the ever growing HLA allele database, tissue typing laboratories face substantial challenges. In light of the complexity and the high degree of allelic diversity, it has become increasingly difficult to define the classical transplantation antigens at high-resolution by using well-tried methods. Thus, next-generation sequencing is entering into diagnostic laboratories at the perfect time and serving as a promising tool to overcome intrinsic HLA typing problems. Therefore, we have developed and validated a scalable automated HLA class I and class II typing approach suitable for diagnostic use. Results A validation panel of 173 clinical and proficiency testing samples was analysed, demonstrating 100% concordance to the reference method. From a total of 1,273 loci we were able to generate 1,241 (97.3%) initial successful typings. The mean ambiguity reduction for the analysed loci was 93.5%. Allele assignment including intronic sequences showed an improved resolution (99.2%) of non-expressed HLA alleles. Conclusion We provide a powerful HLA typing protocol offering a short turnaround time of only two days, a fully integrated workflow and most importantly a high degree of typing reliability. The presented automated assay is flexible and can be scaled by specific primer compilations and the use of different 454 sequencing systems. The workflow was successfully validated according to the policies of the European Federation for Immunogenetics. Next-generation sequencing seems to become one of the new methods in the field of Histocompatibility. PMID:23557197

High-spatial resolution and high-spectral resolution detector for use in the measurement of solar flare hard X-rays

NASA Technical Reports Server (NTRS)

Desai, U. D.; Orwig, Larry E.

1988-01-01

In the areas of high spatial resolution, the evaluation of a hard X-ray detector with 65 micron spatial resolution for operation in the energy range from 30 to 400 keV is proposed. The basic detector is a thick large-area scintillator faceplate, composed of a matrix of high-density scintillating glass fibers, attached to a proximity type image intensifier tube with a resistive-anode digital readout system. Such a detector, combined with a coded-aperture mask, would be ideal for use as a modest-sized hard X-ray imaging instrument up to X-ray energies as high as several hundred keV. As an integral part of this study it was also proposed that several techniques be critically evaluated for X-ray image coding which could be used with this detector. In the area of high spectral resolution, it is proposed to evaluate two different types of detectors for use as X-ray spectrometers for solar flares: planar silicon detectors and high-purity germanium detectors (HPGe). Instruments utilizing these high-spatial-resolution detectors for hard X-ray imaging measurements from 30 to 400 keV and high-spectral-resolution detectors for measurements over a similar energy range would be ideally suited for making crucial solar flare observations during the upcoming maximum in the solar cycle.

Baseline impedance measured during high-resolution esophageal impedance manometry reliably discriminates GERD patients.

PubMed

Ravi, K; Geno, D M; Vela, M F; Crowell, M D; Katzka, D A

2017-05-01

Baseline impedance measured with ambulatory impedance pH monitoring (MII-pH) and a mucosal impedance catheter detects gastroesophageal reflux disease (GERD). However, these tools are limited by cost or patient tolerance. We investigated whether baseline impedance measured during high-resolution impedance manometry (HRIM) distinguishes GERD patients from controls. Consecutive patients with clinical HRIM and MII-pH testing were identified. Gastroesophageal reflux disease was defined by esophageal pH <4 for ≥5% of both the supine and total study time, whereas controls had an esophageal pH <4 for ≤3% of the study performed off PPI. Baseline impedance was measured over 15 seconds during the landmark period of HRIM and over three 10 minute intervals during the overnight period of MII-pH. Among 29 GERD patients and 26 controls, GERD patients had a mean esophageal acid exposure time of 22.7% compared to 1.2% in controls (P<.0001). Mean baseline impedance during HRIM was lower in GERD (1061 Ω) than controls (2814 Ω) (P<.0001). Baseline mucosal impedance measured during HRIM and MII-pH correlated (r=0.59, P<.0001). High-resolution esophageal manometry baseline impedance had high diagnostic accuracy for GERD, with an area under the curve (AUC) of 0.931 on receiver operating characteristics (ROC) analysis. A HRIM baseline impedance threshold of 1582 Ω had a sensitivity of 86.2% and specificity of 88.5% for GERD, with a positive predictive value of 89.3% and negative predictive value of 85.2%. Baseline impedance measured during HRIM can reliably discriminate GERD patients with at least moderate esophageal acid exposure from controls. This diagnostic tool may represent an accurate, cost-effective, and less invasive test for GERD. © 2016 John Wiley & Sons Ltd.

High resolution MR microscopy

NASA Astrophysics Data System (ADS)

Ciobanu, Luisa

images on phantoms [11, 12] and biological samples (paramecia, algae, brain tissue, lipidic mesophases) obtained using using magnetic field gradients as large as 50 Tesla/meter (5000 G/cm) [13] and micro-coils [14]. Images have voxel resolution as high as (3.7 mum by 3.3 mum by 3.3 mum), or 41 mu m3 (41 femtoliters, containing 2.7 x 10 12 proton spins) [12], marginally the highest voxel resolution reported to date. They are also fully three dimensional, with wide fields of view.

Solar Flares Observed with the Ramaty High Energy Solar Spectroscopic Imager (RHESSI)

NASA Technical Reports Server (NTRS)

Holman, Gordon D.

2004-01-01

Solar flares are impressive examples of explosive energy release in unconfined, magnetized plasma. It is generally believed that the flare energy is derived from the coronal magnetic field. However, we have not been able to establish the specific energy release mechanism(s) or the relative partitioning of the released energy between heating, particle acceleration (electrons and ions), and mass motions. NASA's RHESSI Mission was designed to study the acceleration and evolution of electrons and ions in flares by observing the X-ray and gamma-ray emissions these energetic particles produce. This is accomplished through the combination of high-resolution spectroscopy and spectroscopic imaging, including the first images of flares in gamma rays. RHESSI has observed over 12,000 solar flares since its launch on February 5, 2002. I will demonstrate how we use the RHESSI spectra to deduce physical properties of accelerated electrons and hot plasma in flares. Using images to estimate volumes, w e typically find that the total energy in accelerated electrons is comparable to that in the thermal plasma. I will also present flare observations that provide strong support for the presence of magnetic reconnection in a large-scale, vertical current sheet in the solar corona. RHESSI observations such as these are allowing us to probe more deeply into the physics of solar flares.

CARMENES at PPVI. High-Resolution Spectroscopy of M Dwarfs with FEROS, CAFE and HRS

NASA Astrophysics Data System (ADS)

Alonso-Floriano, F. J.; Montes, D.; Jeffers, S.; Caballero, J. A.; Zechmeister, M.; Mundt, R.; Reiners, A.; Amado, P. J.; Casal, E.; Cortés-Contreras, M.; Modroño, Z.; Ribas, I.; Rodríguez-López, C.; Quirrenbach, A.

2013-07-01

To ensure an efficient use of CARMENES observing time, and the highest chances of success, it is necessary first to select the most promising targets. To achieve this, we are observing ~500 M dwarfs at high-resolution (R = 30,000-48,000), from which we determine the projected rotational velocity vsini with an accuracy better than 0.5-0.2 km/s and radial-velocity stability better than 0.2-0.1 km/s. Our aim is to have at least two spectra at different epochs of the final 300 CARMENES targets. Our observations with FEROS at ESO/MPG 2.2m La Silla , CAFE at 2.2m Calar Alto and HRS at Hobby Eberly Telescope allow us to identify single- and double-line spectroscopic binaries and, especially, fast rotators, which should be discarded from the target list for exoplanet searches. Here we present preliminary results.

Diagnostics of Plasma Propulsion Devices

NASA Astrophysics Data System (ADS)

Cappelli, Mark A.

1998-11-01

Plasma rockets are rapidly emerging as critical technologies in future space flight. These devices take on various forms, ranging from electro-thermal to electromagnetic accelerators, generally categorized by the method in which electrical energy is converted to thrust. As is the case in many plasma devices, non-intrusive optical (emission, or laser-based) diagnostics is an essential element in the characterization of these plasma sources, as access to the discharges in these plasma engines is often limited. Furthermore, laser-based diagnostics offer additional benefits, including improved spatial resolution, and can provide state-specific measurements of species densities, velocities and energy distributions. In recent years, we have developed and applied a variety of emission and laser-based diagnostics strategies to the characterization of arcjet plasma and closed-drift xenon Hall plasma accelerators. Both of these types of plasma propulsion devices are of immediate interest to the space propulsion community, and are under varying stages of development. Arcjet thrusters have unique properties, with strong plasma density, temperature and velocity gradients, which enhance the coupling between the gasdynamic and plasma physics. Closed-drift Hall plasma thrusters are low density electrostatic devices that are inherently turbulent, and exhibit varying degrees of anomalous cross-field electron transport. Our most extensive, collective effort has been to apply laser-induced fluorescence, Doppler-free laser absorption, and Raman scattering to the characterization of hydrogen and helium arcjet flows. Detailed measurements of velocity, temperatures, and electron densities are compared to the results of magneto-hydrodynamic flowfield simulations. The results show that while the simulations capture many aspects of the flow, there are still some unresolved discrepancies. The database established for Hall thrusters is less extensive, as the laser absorption spectroscopy of

Extension of least squares spectral resolution algorithm to high-resolution lipidomics data.

PubMed

Zeng, Ying-Xu; Mjøs, Svein Are; David, Fabrice P A; Schmid, Adrien W

2016-03-31

Lipidomics, which focuses on the global study of molecular lipids in biological systems, has been driven tremendously by technical advances in mass spectrometry (MS) instrumentation, particularly high-resolution MS. This requires powerful computational tools that handle the high-throughput lipidomics data analysis. To address this issue, a novel computational tool has been developed for the analysis of high-resolution MS data, including the data pretreatment, visualization, automated identification, deconvolution and quantification of lipid species. The algorithm features the customized generation of a lipid compound library and mass spectral library, which covers the major lipid classes such as glycerolipids, glycerophospholipids and sphingolipids. Next, the algorithm performs least squares resolution of spectra and chromatograms based on the theoretical isotope distribution of molecular ions, which enables automated identification and quantification of molecular lipid species. Currently, this methodology supports analysis of both high and low resolution MS as well as liquid chromatography-MS (LC-MS) lipidomics data. The flexibility of the methodology allows it to be expanded to support more lipid classes and more data interpretation functions, making it a promising tool in lipidomic data analysis. Copyright © 2016 Elsevier B.V. All rights reserved.

High Resolution CryoFESEM of Microbial Surfaces

NASA Astrophysics Data System (ADS)

Erlandsen, Stanley; Lei, Ming; Martin-Lacave, Ines; Dunny, Gary; Wells, Carol

2003-08-01

The outer surfaces of three microorganisms, Giardia lamblia, Enterococcus faecalis, and Proteus mirabilis, were investigated by cryo-immobilization followed by sublimation of extracellular ice and cryocoating with either Pt alone or Pt plus carbon. Cryocoated samples were examined at [minus sign]125°C in either an in-lens field emission SEM or a below-the-lens field emission SEM. Cryocoating with Pt alone was sufficient for low magnification observation, but attempts to do high-resolution imaging resulted in radiolysis and cracking of the specimen surface. Double coating with Pt and carbon, in combination with high resolution backscatter electron detectors, enabled high-resolution imaging of the glycocalyx of bacteria, revealing a sponge-like network over the surface. High resolution examination of bacterial flagella also revealed a periodic substructure. Common artifacts included radiolysis leading to “cracking” of the surface, and insufficient deposition of Pt resulting in the absence of detectable surface topography.

Quantification of steroid hormones in human serum by liquid chromatography-high resolution tandem mass spectrometry.

PubMed

Matysik, Silke; Liebisch, Gerhard

2017-12-01

A limited specificity is inherent to immunoassays for steroid hormone analysis. To improve selectivity mass spectrometric analysis of steroid hormones by liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been introduced in the clinical laboratory over the past years usually with low mass resolution triple-quadrupole instruments or more recently by high resolution mass spectrometry (HR-MS). Here we introduce liquid chromatography-high resolution tandem mass spectrometry (LC-MS/HR-MS) to further increase selectivity of steroid hormone quantification. Application of HR-MS demonstrates an enhanced selectivity compared to low mass resolution. Separation of isobaric interferences reduces background noise and avoids overestimation. Samples were prepared by automated liquid-liquid extraction with MTBE. The LC-MS/HR-MS method using a quadrupole-Orbitrap analyzer includes eight steroid hormones i.e. androstenedione, corticosterone, cortisol, cortisone, 11-deoxycortisol, 17-hydroxyprogesterone, progesterone, and testosterone. It has a run-time of 5.3min and was validated according to the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) guidelines. For most of the analytes coefficient of variation were 10% or lower and LOQs were determined significantly below 1ng/ml. Full product ion spectra including accurate masses substantiate compound identification by matching their masses and ratios with authentic standards. In summary, quantification of steroid hormones by LC-MS/HR-MS is applicable for clinical diagnostics and holds also promise for highly selective quantification of other small molecules. Copyright © 2017 Elsevier B.V. All rights reserved.

Field Red Horizontal Branch Star Chemical Compositions from High Resolution Infrared Spectra

NASA Astrophysics Data System (ADS)

Sneden, Chris; Afsar, Melike; Bozkurt, Zeynep; Bocek-Topcu, Gamze; Mace, Gregory N.; Kim, Hwihyun; Kaplan, Kyle; Kidder, Benjamin; McLane, Jacob

2017-06-01

We have observed three field red horizontal branch stars with the Immersion Grating Infrared Spectrograph (IGRINS). The high resolution (R~45000) high signal-to-noise (S/N > 200) spectra obtained with IGRINS cover the complete H-band (1.50-1.80 micron) and K-band (1.90-2.45 micron). We analyzed hundreds of lines of the ubiquitous OH, CN, and CO molecular bands, and found more than 80 lines of atomic species that were useful for abundance work. A combination of good laboratory transition probabilities (when available) and ones derived from reverse solar analyses were employed. Our transition data were checked through studies of the Arcturus Atlas spectrum. We derived abundances from synthetic spectra instead of from equivalent widths. With IGRINS data we were able to extract metallicities and abundance ratios for more than 20 elements, including several not detectable or poorly represented in optical wavelength regions. Our abundances from IGRINS spectra are in excellent accord with those derived from optical spectrum studies. These results are directly applicable to calibrations of results from lower-resolution and/or S/N infrared spectral surveys. IGRINS observations will give high reolution spectroscopic access to heavily obscured normal red giants and other cool stars with unusual element mixes.This work used the Immersion Grating Infrared Spectrograph (IGRINS) that was developed under a collaboration between the University of Texas at Austin and the Korea Astronomy and Space Science Institute (KASI) with the financial support of the US National Science Foundation (NSF; grant AST-1229522), of the University of Texas at Austin, and of the Korean GMT Project of KASI. Our project also has been supported by NSF grants AST~1211585 and AST~1616040, by the University of Texas Rex G. Baker, Jr. Centennial Research Endowment, and by The Scientific and Technological Research Council of Turkey (TUBITAK, project No. 112T929).

Next-generation endomyocardial biopsy: the potential of confocal and super-resolution microscopy.

PubMed

Crossman, David J; Ruygrok, Peter N; Hou, Yu Feng; Soeller, Christian

2015-03-01

Confocal laser scanning microscopy and super-resolution microscopy provide high-contrast and high-resolution fluorescent imaging, which has great potential to increase the diagnostic yield of endomyocardial biopsy (EMB). EMB is currently the gold standard for identification of cardiac allograft rejection, myocarditis, and infiltrative and storage diseases. However, standard analysis is dominated by low-contrast bright-field light and electron microscopy (EM); this lack of contrast makes quantification of pathological features difficult. For example, assessment of cardiac allograft rejection relies on subjective grading of H&E histology, which may lead to diagnostic variability between pathologists. This issue could be solved by utilising the high contrast provided by fluorescence methods such as confocal to quantitatively assess the degree of lymphocytic infiltrate. For infiltrative diseases such as amyloidosis, the nanometre resolution provided by EM can be diagnostic in identifying disease-causing fibrils. The recent advent of super-resolution imaging, particularly direct stochastic optical reconstruction microscopy (dSTORM), provides high-contrast imaging at resolution approaching that of EM. Moreover, dSTORM utilises conventional fluorescence dyes allowing for the same structures to be routinely imaged at the cellular scale and then at the nanoscale. The key benefit of these technologies is that the high contrast facilitates quantitative digital analysis and thereby provides a means to robustly assess critical pathological features. Ultimately, this technology has the ability to provide greater accuracy and precision to EMB assessment, which could result in better outcomes for patients.

Development of miniaturized, spectroscopically assisted Penning gauges for fractional helium and hydrogen neutral pressure measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flesch, K.; Kremeyer, T.; Schmitz, O.

Direct measurements of the helium (He) fractional neutral pressure in the neutral gas around fusion devices is challenging because of the small mass difference between the abundant D-2 molecules and the He ash which will be produced by deuterium-tritium fusion. In order to study He exhaust, an in situ Penning gauge system is being developed at UW-Madison that is optimized for good pressure and high spectroscopic sensitivity. There are three different anode geometries that we have studied regarding their vacuum electrostatic fields, light output, and ion current. The light output of the two new anode configurations are at least onemore » order of magnitude above the currently available designs, hence improving the spectroscopic sensitivity at similar total neutral pressure resolution.« less

Development of miniaturized, spectroscopically assisted Penning gauges for fractional helium and hydrogen neutral pressure measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flesch, K., E-mail: kbflesch@wisc.edu; Kremeyer, T.; Schmitz, O.

Direct measurements of the helium (He) fractional neutral pressure in the neutral gas around fusion devices is challenging because of the small mass difference between the abundant D{sub 2} molecules and the He ash which will be produced by deuterium-tritium fusion. To study He exhaust, an in situ Penning gauge system is being developed at UW-Madison that is optimized for good pressure and high spectroscopic sensitivity. Three different anode geometries have been studied regarding their vacuum electrostatic fields, light output, and ion current. The light output of the two new anode configurations are at least one order of magnitude abovemore » the currently available designs, hence improving the spectroscopic sensitivity at similar total neutral pressure resolution.« less

Development of miniaturized, spectroscopically assisted Penning gauges for fractional helium and hydrogen neutral pressure measurements

DOE PAGES

Flesch, K.; Kremeyer, T.; Schmitz, O.; ...

2016-08-18

Direct measurements of the helium (He) fractional neutral pressure in the neutral gas around fusion devices is challenging because of the small mass difference between the abundant D-2 molecules and the He ash which will be produced by deuterium-tritium fusion. In order to study He exhaust, an in situ Penning gauge system is being developed at UW-Madison that is optimized for good pressure and high spectroscopic sensitivity. There are three different anode geometries that we have studied regarding their vacuum electrostatic fields, light output, and ion current. The light output of the two new anode configurations are at least onemore » order of magnitude above the currently available designs, hence improving the spectroscopic sensitivity at similar total neutral pressure resolution.« less

High-resolution regional climate model evaluation using variable-resolution CESM over California

NASA Astrophysics Data System (ADS)

Huang, X.; Rhoades, A.; Ullrich, P. A.; Zarzycki, C. M.

2015-12-01

Understanding the effect of climate change at regional scales remains a topic of intensive research. Though computational constraints remain a problem, high horizontal resolution is needed to represent topographic forcing, which is a significant driver of local climate variability. Although regional climate models (RCMs) have traditionally been used at these scales, variable-resolution global climate models (VRGCMs) have recently arisen as an alternative for studying regional weather and climate allowing two-way interaction between these domains without the need for nudging. In this study, the recently developed variable-resolution option within the Community Earth System Model (CESM) is assessed for long-term regional climate modeling over California. Our variable-resolution simulations will focus on relatively high resolutions for climate assessment, namely 28km and 14km regional resolution, which are much more typical for dynamically downscaled studies. For comparison with the more widely used RCM method, the Weather Research and Forecasting (WRF) model will be used for simulations at 27km and 9km. All simulations use the AMIP (Atmospheric Model Intercomparison Project) protocols. The time period is from 1979-01-01 to 2005-12-31 (UTC), and year 1979 was discarded as spin up time. The mean climatology across California's diverse climate zones, including temperature and precipitation, is analyzed and contrasted with the Weather Research and Forcasting (WRF) model (as a traditional RCM), regional reanalysis, gridded observational datasets and uniform high-resolution CESM at 0.25 degree with the finite volume (FV) dynamical core. The results show that variable-resolution CESM is competitive in representing regional climatology on both annual and seasonal time scales. This assessment adds value to the use of VRGCMs for projecting climate change over the coming century and improve our understanding of both past and future regional climate related to fine

An ALMA Survey of Submillimeter Galaxies in the Extended Chandra Deep Field South: Spectroscopic Redshifts

NASA Astrophysics Data System (ADS)

Danielson, A. L. R.; Swinbank, A. M.; Smail, Ian; Simpson, J. M.; Casey, C. M.; Chapman, S. C.; da Cunha, E.; Hodge, J. A.; Walter, F.; Wardlow, J. L.; Alexander, D. M.; Brandt, W. N.; de Breuck, C.; Coppin, K. E. K.; Dannerbauer, H.; Dickinson, M.; Edge, A. C.; Gawiser, E.; Ivison, R. J.; Karim, A.; Kovacs, A.; Lutz, D.; Menten, K.; Schinnerer, E.; Weiß, A.; van der Werf, P.

2017-05-01

We present spectroscopic redshifts of {\\text{}}{S}870μ {{m}} ≳ 2 mJy submillimeter galaxies (SMGs), which have been identified from the ALMA follow-up observations of 870 μm detected sources in the Extended Chandra Deep Field South (the ALMA-LESS survey). We derive spectroscopic redshifts for 52 SMGs, with a median of z = 2.4 ± 0.1. However, the distribution features a high-redshift tail, with ˜23% of the SMGs at z≥slant 3. Spectral diagnostics suggest that the SMGs are young starbursts, and the velocity offsets between the nebular emission and UV ISM absorption lines suggest that many are driving winds, with velocity offsets of up to 2000 km s-1. Using the spectroscopic redshifts and the extensive UV-to-radio photometry in this field, we produce optimized spectral energy distributions (SEDs) using Magphys, and use the SEDs to infer a median stellar mass of {M}\\star = (6 ± 1)× 1010 M {}⊙ for our SMGs with spectroscopic redshift. By combining these stellar masses with the star formation rates (measured from the far-infrared SEDs), we show that SMGs (on average) lie a factor of ˜5 above the so-called “main sequence” at z˜ 2. We provide this library of 52 template fits with robust and uniquely well-sampled SEDs as a resource for future studies of SMGs, and also release the spectroscopic catalog of ˜2000 (mostly infrared-selected) galaxies targeted as part of the spectroscopic campaign.

X-ray And EUV Spectroscopy Of Highly Charged Tungsten Ions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biedermann, Christoph; Radtke, Rainer

2009-09-10

The Berlin EBIT has been established by the Max-Planck-Institut fuer Plasmaphysik to generate atomic physics data in support of research in the field of controlled nuclear fusion, by measuring the radiation from highly charged ions in the x-ray, extreme ultraviolet and visible spectral ranges and providing valuable diagnostics for high temperature plasmas. In future fusion devices, for example ITER, currently being constructed at Cadarache, France, the plasma facing components will be armored with high-Z materials, most likely tungsten, due to the favorable properties of this element. At the same time the tremendous radiation cooling of these high-Z materials represents amore » threat to fusion and obliges one to monitor carefully the radiation. With EBIT a selected ensemble of ions in specific charge states can be produced, stored and excited for spectroscopic investigations. Employing this technique, we have for example resolved the wide structure observed around 5 nm at the ASDEX Upgrade tokamak as originating from E1-transitions into the open 4d shell of tungsten ions in charge states 25+ to 37+ producing a band-like emission pattern. Further, these ions emit well-separated M1 lines in the EUV range around 65 nm suitable for plasma diagnostics. Kr-like to Cr-like tungsten ions (38+ to 50+) show strong soft-x-ray lines in the range 0.5 to 2 and 5 to 15 nm. Lines of even higher charged tungsten ions, up to Ne-like W{sup 64+}, abundant in the core plasma of present and future fusion test devices, have been investigated with high resolution Bragg-crystal spectroscopy at 0.13 nm. Recently, x-ray spectroscopic measurements of the dielectronic recombination LMn resonances of W{sup 60+} to W{sup 67+} ions have been preformed and compare well with atomic structure calculations.« less

Investigating the effect of pixel size of high spatial resolution FTIR imaging for detection of colorectal cancer

NASA Astrophysics Data System (ADS)

Lloyd, G. R.; Nallala, J.; Stone, N.

2016-03-01

FTIR is a well-established technique and there is significant interest in applying this technique to medical diagnostics e.g. to detect cancer. The introduction of focal plane array (FPA) detectors means that FTIR is particularly suited to rapid imaging of biopsy sections as an adjunct to digital pathology. Until recently however each pixel in the image has been limited to a minimum of 5.5 µm which results in a comparatively low magnification image or histology applications and potentially the loss of important diagnostic information. The recent introduction of higher magnification optics gives image pixels that cover approx. 1.1 µm. This reduction in image pixel size gives images of higher magnification and improved spatial detail can be observed. However, the effect of increasing the magnification on spectral quality and the ability to discriminate between disease states is not well studied. In this work we test the discriminatory performance of FTIR imaging using both standard (5.5 µm) and high (1.1 µm) magnification for the detection of colorectal cancer and explore the effect of binning to degrade high resolution images to determine whether similar diagnostic information and performance can be obtained using both magnifications. Results indicate that diagnostic performance using high magnification may be reduced as compared to standard magnification when using existing multivariate approaches. Reduction of the high magnification data to standard magnification via binning can potentially recover some of the lost performance.

High-Resolution Data for a Low-Resolution World

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brady, Brendan Williams

2016-05-10

In the past 15 years, the upper section of Cañon de Valle has been severely altered by wildfires and subsequent runoff events. Loss of root structures on high-angle slopes results in debris flow and sediment accumulation in the narrow canyon bottom. The original intent of the study described here was to better understand the changes occurring in watershed soil elevations over the course of several post-fire years. An elevation dataset from 5 years post-Cerro Grande fire was compared to high-resolution LiDAR data from 14 years post-Cerro Grande fire (also 3 years post-Las Conchas fire). The following analysis was motivated bymore » a problematic comparison of these datasets of unlike resolution, and therefore focuses on what the data reveals of itself. The objective of this study is to highlight the effects vegetation can have on remote sensing data that intends to read ground surface elevation.« less

High-resolution electron microscope

NASA Technical Reports Server (NTRS)

Nathan, R.

1977-01-01

Employing scanning transmission electron microscope as interferometer, relative phases of diffraction maximums can be determined by analysis of dark field images. Synthetic aperture technique and Fourier-transform computer processing of amplitude and phase information provide high resolution images at approximately one angstrom.

High angular resolution at LBT

NASA Astrophysics Data System (ADS)

Conrad, A.; Arcidiacono, C.; Bertero, M.; Boccacci, P.; Davies, A. G.; Defrere, D.; de Kleer, K.; De Pater, I.; Hinz, P.; Hofmann, K. H.; La Camera, A.; Leisenring, J.; Kürster, M.; Rathbun, J. A.; Schertl, D.; Skemer, A.; Skrutskie, M.; Spencer, J. R.; Veillet, C.; Weigelt, G.; Woodward, C. E.

2015-12-01

High angular resolution from ground-based observatories stands as a key technology for advancing planetary science. In the window between the angular resolution achievable with 8-10 meter class telescopes, and the 23-to-40 meter giants of the future, LBT provides a glimpse of what the next generation of instruments providing higher angular resolution will provide. We present first ever resolved images of an Io eruption site taken from the ground, images of Io's Loki Patera taken with Fizeau imaging at the 22.8 meter LBT [Conrad, et al., AJ, 2015]. We will also present preliminary analysis of two data sets acquired during the 2015 opposition: L-band fringes at Kurdalagon and an occultation of Loki and Pele by Europa (see figure). The light curves from this occultation will yield an order of magnitude improvement in spatial resolution along the path of ingress and egress. We will conclude by providing an overview of the overall benefit of recent and future advances in angular resolution for planetary science.

A spectroscopic transfer standard for accurate atmospheric CO measurements

NASA Astrophysics Data System (ADS)

Nwaboh, Javis A.; Li, Gang; Serdyukov, Anton; Werhahn, Olav; Ebert, Volker

2016-04-01

Atmospheric carbon monoxide (CO) is a precursor of essential climate variables and has an indirect effect for enhancing global warming. Accurate and reliable measurements of atmospheric CO concentration are becoming indispensable. WMO-GAW reports states a compatibility goal of ±2 ppb for atmospheric CO concentration measurements. Therefore, the EMRP-HIGHGAS (European metrology research program - high-impact greenhouse gases) project aims at developing spectroscopic transfer standards for CO concentration measurements to meet this goal. A spectroscopic transfer standard would provide results that are directly traceable to the SI, can be very useful for calibration of devices operating in the field, and could complement classical gas standards in the field where calibration gas mixtures in bottles often are not accurate, available or stable enough [1][2]. Here, we present our new direct tunable diode laser absorption spectroscopy (dTDLAS) sensor capable of performing absolute ("calibration free") CO concentration measurements, and being operated as a spectroscopic transfer standard. To achieve the compatibility goal stated by WMO for CO concentration measurements and ensure the traceability of the final concentration results, traceable spectral line data especially line intensities with appropriate uncertainties are needed. Therefore, we utilize our new high-resolution Fourier-transform infrared (FTIR) spectroscopy CO line data for the 2-0 band, with significantly reduced uncertainties, for the dTDLAS data evaluation. Further, we demonstrate the capability of our sensor for atmospheric CO measurements, discuss uncertainty calculation following the guide to the expression of uncertainty in measurement (GUM) principles and show that CO concentrations derived using the sensor, based on the TILSAM (traceable infrared laser spectroscopic amount fraction measurement) method, are in excellent agreement with gravimetric values. Acknowledgement Parts of this work have been

A method for generating high resolution satellite image time series

NASA Astrophysics Data System (ADS)

Guo, Tao

2014-10-01

There is an increasing demand for satellite remote sensing data with both high spatial and temporal resolution in many applications. But it still is a challenge to simultaneously improve spatial resolution and temporal frequency due to the technical limits of current satellite observation systems. To this end, much R&D efforts have been ongoing for years and lead to some successes roughly in two aspects, one includes super resolution, pan-sharpen etc. methods which can effectively enhance the spatial resolution and generate good visual effects, but hardly preserve spectral signatures and result in inadequate analytical value, on the other hand, time interpolation is a straight forward method to increase temporal frequency, however it increase little informative contents in fact. In this paper we presented a novel method to simulate high resolution time series data by combing low resolution time series data and a very small number of high resolution data only. Our method starts with a pair of high and low resolution data set, and then a spatial registration is done by introducing LDA model to map high and low resolution pixels correspondingly. Afterwards, temporal change information is captured through a comparison of low resolution time series data, and then projected onto the high resolution data plane and assigned to each high resolution pixel according to the predefined temporal change patterns of each type of ground objects. Finally the simulated high resolution data is generated. A preliminary experiment shows that our method can simulate a high resolution data with a reasonable accuracy. The contribution of our method is to enable timely monitoring of temporal changes through analysis of time sequence of low resolution images only, and usage of costly high resolution data can be reduces as much as possible, and it presents a highly effective way to build up an economically operational monitoring solution for agriculture, forest, land use investigation

Photometric and spectroscopic gamma-ray observations of solar transient phenomena using long duration balloons

NASA Technical Reports Server (NTRS)

Pelling, M. R.; Duttweiler, F.; Lin, R. F.; Levedahl, W. K.; Primbach, H.; Curtis, D. W.; Burley, K. C.

1985-01-01

A program currently in progress to conduct extended duration spectroscopic and photometric observation of solar X-ray phenomena from balloons is described. High photometric sensitivity to weak hard X-ray bursts is attained using a 600 sq cm array of phoswich scintillators. High spectral resolution for stronger bursts is available from an array of planar germanium detectors. These instruments are carried in a novel balloon gondola dssigned for the 15 to 20 day float durations available through using conventional zero pressure balloons in the radiation controlled (RACOON) mode.

Photometric and spectroscopic gamma-ray observations of solar transient phenomena using long duration balloons

NASA Astrophysics Data System (ADS)

Pelling, M. R.; Duttweiler, F.; Lin, R. F.; Levedahl, W. K.; Primbach, H.; Curtis, D. W.; Burley, K. C.

1985-08-01

A program currently in progress to conduct extended duration spectroscopic and photometric observation of solar X-ray phenomena from balloons is described. High photometric sensitivity to weak hard X-ray bursts is attained using a 600 sq cm array of phoswich scintillators. High spectral resolution for stronger bursts is available from an array of planar germanium detectors. These instruments are carried in a novel balloon gondola dssigned for the 15 to 20 day float durations available through using conventional zero pressure balloons in the radiation controlled (RACOON) mode.

Unbiased Large Spectroscopic Surveys of Galaxies Selected by SPICA Using Dust Bands

NASA Astrophysics Data System (ADS)

Kaneda, H.; Ishihara, D.; Oyabu, S.; Yamagishi, M.; Wada, T.; Armus, L.; Baes, M.; Charmandaris, V.; Czerny, B.; Efstathiou, A.; Fernández-Ontiveros, J. A.; Ferrara, A.; González-Alfonso, E.; Griffin, M.; Gruppioni, C.; Hatziminaoglou, E.; Imanishi, M.; Kohno, K.; Kwon, J.; Nakagawa, T.; Onaka, T.; Pozzi, F.; Scott, D.; Smith, J.-D. T.; Spinoglio, L.; Suzuki, T.; van der Tak, F.; Vaccari, M.; Vignali, C.; Wang, L.

2017-11-01

The mid-infrared range contains many spectral features associated with large molecules and dust grains such as polycyclic aromatic hydrocarbons and silicates. These are usually very strong compared to fine-structure gas lines, and thus valuable in studying the spectral properties of faint distant galaxies. In this paper, we evaluate the capability of low-resolution mid-infrared spectroscopic surveys of galaxies that could be performed by SPICA. The surveys are designed to address the question how star formation and black hole accretion activities evolved over cosmic time through spectral diagnostics of the physical conditions of the interstellar/circumnuclear media in galaxies. On the basis of results obtained with Herschel far-infrared photometric surveys of distant galaxies and Spitzer and AKARI near- to mid-infrared spectroscopic observations of nearby galaxies, we estimate the numbers of the galaxies at redshift z > 0.5, which are expected to be detected in the polycyclic aromatic hydrocarbon features or dust continuum by a wide (10 deg2) or deep (1 deg2) blind survey, both for a given observation time of 600 h. As by-products of the wide blind survey, we also expect to detect debris disks, through the mid-infrared excess above the photospheric emission of nearby main-sequence stars, and we estimate their number. We demonstrate that the SPICA mid-infrared surveys will efficiently provide us with unprecedentedly large spectral samples, which can be studied further in the far-infrared with SPICA.

Progress Towards Spectroscopic Diagnostics of Plasma Parameters and Neutral Dynamics in Helicon Plasmas

NASA Astrophysics Data System (ADS)

Green, Jonathan; Schmitz, Oliver; Severn, Greg; van Ruremonde, Lars; Winters, Victoria

2017-10-01

The MARIA device at the UW-Madison is used primarily to investigate the dynamics and fueling of neutral particles in helicon discharges. A new systematic method is in development to measure key plasma and neutral particle parameters by spectroscopic methods. The setup relies on spectroscopic line ratios for investigating basic plasma parameters and extrapolation to other states using a collisional radiative model. Active pumping using a Nd:YAG pumped dye laser is used to benchmark and correct the underlying atomic data for the collisional radiative model. First results show a matching linear dependence between electron density and laser induced fluorescence on the magnetic field above 500G. This linear dependence agrees with the helicon dispersion relation and implies MARIA can reliably support the helicon mode and support future measurements. This work was funded by the NSF CAREER award PHY-1455210.

High spatial resolution compressed sensing (HSPARSE) functional MRI.

PubMed

Fang, Zhongnan; Van Le, Nguyen; Choy, ManKin; Lee, Jin Hyung

2016-08-01

To propose a novel compressed sensing (CS) high spatial resolution functional MRI (fMRI) method and demonstrate the advantages and limitations of using CS for high spatial resolution fMRI. A randomly undersampled variable density spiral trajectory enabling an acceleration factor of 5.3 was designed with a balanced steady state free precession sequence to achieve high spatial resolution data acquisition. A modified k-t SPARSE method was then implemented and applied with a strategy to optimize regularization parameters for consistent, high quality CS reconstruction. The proposed method improves spatial resolution by six-fold with 12 to 47% contrast-to-noise ratio (CNR), 33 to 117% F-value improvement and maintains the same temporal resolution. It also achieves high sensitivity of 69 to 99% compared the original ground-truth, small false positive rate of less than 0.05 and low hemodynamic response function distortion across a wide range of CNRs. The proposed method is robust to physiological noise and enables detection of layer-specific activities in vivo, which cannot be resolved using the highest spatial resolution Nyquist acquisition. The proposed method enables high spatial resolution fMRI that can resolve layer-specific brain activity and demonstrates the significant improvement that CS can bring to high spatial resolution fMRI. Magn Reson Med 76:440-455, 2016. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.

High-resolution multi-band imaging for validation and characterization of small Kepler planets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Everett, Mark E.; Silva, David R.; Barclay, Thomas

2015-02-01

High-resolution ground-based optical speckle and near-infrared adaptive optics images are taken to search for stars in close angular proximity to host stars of candidate planets identified by the NASA Kepler Mission. Neighboring stars are a potential source of false positive signals. These stars also blend into Kepler light curves, affecting estimated planet properties, and are important for an understanding of planets in multiple star systems. Deep images with high angular resolution help to validate candidate planets by excluding potential background eclipsing binaries as the source of the transit signals. A study of 18 Kepler Object of Interest stars hosting amore » total of 28 candidate and validated planets is presented. Validation levels are determined for 18 planets against the likelihood of a false positive from a background eclipsing binary. Most of these are validated at the 99% level or higher, including five newly validated planets in two systems: Kepler-430 and Kepler-431. The stellar properties of the candidate host stars are determined by supplementing existing literature values with new spectroscopic characterizations. Close neighbors of seven of these stars are examined using multi-wavelength photometry to determine their nature and influence on the candidate planet properties. Most of the close neighbors appear to be gravitationally bound secondaries, while a few are best explained as closely co-aligned field stars. Revised planet properties are derived for each candidate and validated planet, including cases where the close neighbors are the potential host stars.« less

Standoff spectroscopic interrogation of samples irradiated by high energy lasers

NASA Astrophysics Data System (ADS)

Daigle, Jean-François; Pudo, Dominik; Théberge, Francis

2017-10-01

We report on a novel method that shows the potential to provide real-time, standoff forensic analysis of samples being irradiated by a high energy laser (HEL). The interaction of the HEL beam with matter produces specific optical signatures that can be detected from the location of the HEL system. A spectroscopic analysis of these signals can then provide useful information to the operator including the impact the laser has on the sample as well as providing data about the its structure and composition.

High resolution spectrograph. [for LST

NASA Technical Reports Server (NTRS)

Peacock, K.

1975-01-01

The high resolution spectrograph (HRS) is designed to be used with the Large Space Telescope (LST) for the study of spectra of point and extended targets in the spectral range 110 to 410 nm. It has spectral resolutions of 1,000; 30,000; and 100,000 and has a field of view as large as 10 arc sec. The spectral range and resolution are selectable using interchangeable optical components and an echelle spectrograph is used to display a cross dispersed spectrum on the photocathode of either of 2 SEC orthicon image tubes. Provisions are included for wavelength calibration, target identification and acquisition and thermal control. The system considerations of the instrument are described.

Efficacy of a high-resolution consultation system in gastroenterology at an Andalusian hospital center.

PubMed

Zambrana-García, José Luis; Montoro-Caba, María Isabel; Chicano-Gallardo, Maite; Monrobel-Lancho, Ana; Pérez-de-Luque, Daniel Jesús; Peña-Ojeda, José Antonio; Recio-Ramírez, José Manuel

2016-01-01

By high resolution consultation (HRC) we mean an ambulatory process of assistance fulfilled in a single day, by which treatment and diagnosis are established and recorded. To assess to which extent patients with digestive conditions may benefit from a single consultation system. A descriptive study of 179 first visit events, randomly selected as high-resolution consultations in gastroenterology. We discuss the percentage of patients who benefited from HRC and the complementary tests performed. Most common conditions included dyspepsia (16%), a family history of colon cancer (16%) and gastroesophageal reflux disease (GERD) (16%). Seventy-nine (44%) of all first visits became HRCs and 80 (45%) required a diagnostic test (100% abdominal ultrasound) that was reviewed on the same day. Performing a test on the same day significantly increased the percentage of HRCs (57% vs. 34%, p < 0.002). GERD, dyspepsia, cholelithiasis and chronic liver disease were the subjects most commonly leading to HRC. Gastroenterology consultations may largely benefit from an HRC system with only organizational changes and no additional costs.

High-resolution sonography for distinguishing neoplastic gallbladder polyps and staging gallbladder cancer.

PubMed

Kim, Jung Hoon; Lee, Jae Young; Baek, Jee Hyun; Eun, Hyo Won; Kim, Young Jae; Han, Joon Koo; Choi, Byung Ihn

2015-02-01

OBJECTIVE. The purposes of this study were to compare staging accuracy of high-resolution sonography (HRUS) with combined low- and high-MHz transducers with that of conventional sonography for gallbladder cancer and to investigate the differences in the imaging findings of neoplastic and nonneoplastic gallbladder polyps. MATERIALS AND METHODS. Our study included 37 surgically proven gallbladder cancer (T1a = 7, T1b = 2, T2 = 22, T3 = 6), including 15 malignant neoplastic polyps and 73 surgically proven polyps (neoplastic = 31, nonneoplastic = 42) that underwent HRUS and conventional transabdominal sonography. Two radiologists assessed T-category and predefined polyp findings on HRUS and conventional transabdominal sonography. Statistical analyses were performed using chi-square and McNemar tests. RESULTS. The diagnostic accuracy for the T category was T1a = 92-95%, T1b = 89-95%, T2 = 78-86%, and T3 = 84-89%, all with good agreement (κ = 0.642) using HRUS. The diagnostic accuracy for differentiating T1 from T2 or greater than T2 was 92% and 89% on HRUS and 65% and 70% with conventional transabdominal sonography. Statistically common findings for neoplastic polyps included size greater than 1 cm, single lobular surface, vascular core, hypoechoic polyp, and hypoechoic foci (p < 0.05). The value of HRUS in the differential diagnosis of a gallbladder polyp was more clearly depicted internal echo foci than conventional transabdominal sonography (39 vs 21). A polyp size greater than 1 cm was independently associated with a neoplastic polyp (odds ratio = 7.5, p = 0.02). The AUC of a polyp size greater than 1 cm was 0.877. The sensitivity and specificity were 66.67% and 89.13%, respectively. CONCLUSION. HRUS is a simple method that enables accurate T categorization of gallbladder carcinoma. It provides high-resolution images of gallbladder polyps and may have a role in stratifying the risk for malignancy.

Nanoantenna-Enhanced Infrared Spectroscopic Chemical Imaging.

PubMed

Kühner, Lucca; Hentschel, Mario; Zschieschang, Ute; Klauk, Hagen; Vogt, Jochen; Huck, Christian; Giessen, Harald; Neubrech, Frank

2017-05-26

Spectroscopic infrared chemical imaging is ideally suited for label-free and spatially resolved characterization of molecular species, but often suffers from low infrared absorption cross sections. Here, we overcome this limitation by utilizing confined electromagnetic near-fields of resonantly excited plasmonic nanoantennas, which enhance the molecular absorption by orders of magnitude. In the experiments, we evaporate microstructured chemical patterns of C 60 and pentacene with nanometer thickness on top of homogeneous arrays of tailored nanoantennas. Broadband mid-infrared spectra containing plasmonic and vibrational information were acquired with diffraction-limited resolution using a two-dimensional focal plane array detector. Evaluating the enhanced infrared absorption at the respective frequencies, spatially resolved chemical images were obtained. In these chemical images, the microstructured chemical patterns are only visible if nanoantennas are used. This confirms the superior performance of our approach over conventional spectroscopic infrared imaging. In addition to the improved sensitivity, our technique provides chemical selectivity, which would not be available with plasmonic imaging that is based on refractive index sensing. To extend the accessible spectral bandwidth of nanoantenna-enhanced spectroscopic imaging, we employed nanostructures with dual-band resonances, providing broadband plasmonic enhancement and sensitivity. Our results demonstrate the potential of nanoantenna-enhanced spectroscopic infrared chemical imaging for spatially resolved characterization of organic layers with thicknesses of several nanometers. This is of potential interest for medical applications which are currently hampered by state-of-art infrared techniques, e.g., for distinguishing cancerous from healthy tissues.

Resolution enhancement of low-quality videos using a high-resolution frame

NASA Astrophysics Data System (ADS)

Pham, Tuan Q.; van Vliet, Lucas J.; Schutte, Klamer

2006-01-01

This paper proposes an example-based Super-Resolution (SR) algorithm of compressed videos in the Discrete Cosine Transform (DCT) domain. Input to the system is a Low-Resolution (LR) compressed video together with a High-Resolution (HR) still image of similar content. Using a training set of corresponding LR-HR pairs of image patches from the HR still image, high-frequency details are transferred from the HR source to the LR video. The DCT-domain algorithm is much faster than example-based SR in spatial domain 6 because of a reduction in search dimensionality, which is a direct result of the compact and uncorrelated DCT representation. Fast searching techniques like tree-structure vector quantization 16 and coherence search1 are also key to the improved efficiency. Preliminary results on MJPEG sequence show promising result of the DCT-domain SR synthesis approach.

A spectroscopic analysis of macrospicules .

NASA Astrophysics Data System (ADS)

Scullion, E.; Doyle, J. G.; Erdélyi, R.

We explore the nature of macrospicule structures, both off-limb and on-disk, and their possible relation to explosive events in the mid-solar atmosphere. We use high resolution spectroscopy obtained with the SoHO/SUMER instrument. We present a highly resolved spectroscopic analysis and line parameter study of time series data for such jets. We focus on two interesting off-limb events which rapidly propagate between the mid-transition region N IV 765 Å line formation (140 000 K) and the lower corona Ne VIII 770 Å line formation (630 000 K). In one example, a strong jet-like event is associated with a cool feature not present in the Ne VIII 770 Å line radiance or Doppler velocity maps. Our data reveals fast, repetitive plasma outflows with blue-shift velocities of ≈ 145 km s-1 in the lower solar atmosphere. The data suggests a strong role for smaller jets (spicules), as a precursor to macrospicule formation, which may have a common origin with explosive events.

A cloud mask methodology for high resolution remote sensing data combining information from high and medium resolution optical sensors

NASA Astrophysics Data System (ADS)

Sedano, Fernando; Kempeneers, Pieter; Strobl, Peter; Kucera, Jan; Vogt, Peter; Seebach, Lucia; San-Miguel-Ayanz, Jesús

2011-09-01

This study presents a novel cloud masking approach for high resolution remote sensing images in the context of land cover mapping. As an advantage to traditional methods, the approach does not rely on thermal bands and it is applicable to images from most high resolution earth observation remote sensing sensors. The methodology couples pixel-based seed identification and object-based region growing. The seed identification stage relies on pixel value comparison between high resolution images and cloud free composites at lower spatial resolution from almost simultaneously acquired dates. The methodology was tested taking SPOT4-HRVIR, SPOT5-HRG and IRS-LISS III as high resolution images and cloud free MODIS composites as reference images. The selected scenes included a wide range of cloud types and surface features. The resulting cloud masks were evaluated through visual comparison. They were also compared with ad-hoc independently generated cloud masks and with the automatic cloud cover assessment algorithm (ACCA). In general the results showed an agreement in detected clouds higher than 95% for clouds larger than 50 ha. The approach produced consistent results identifying and mapping clouds of different type and size over various land surfaces including natural vegetation, agriculture land, built-up areas, water bodies and snow.

Single sensor processing to obtain high resolution color component signals

NASA Technical Reports Server (NTRS)

Glenn, William E. (Inventor)

2010-01-01

A method for generating color video signals representative of color images of a scene includes the following steps: focusing light from the scene on an electronic image sensor via a filter having a tri-color filter pattern; producing, from outputs of the sensor, first and second relatively low resolution luminance signals; producing, from outputs of the sensor, a relatively high resolution luminance signal; producing, from a ratio of the relatively high resolution luminance signal to the first relatively low resolution luminance signal, a high band luminance component signal; producing, from outputs of the sensor, relatively low resolution color component signals; and combining each of the relatively low resolution color component signals with the high band luminance component signal to obtain relatively high resolution color component signals.

High-Resolution Mass Spectrometers

NASA Astrophysics Data System (ADS)

Marshall, Alan G.; Hendrickson, Christopher L.

2008-07-01

Over the past decade, mass spectrometry has been revolutionized by access to instruments of increasingly high mass-resolving power. For small molecules up to ˜400 Da (e.g., drugs, metabolites, and various natural organic mixtures ranging from foods to petroleum), it is possible to determine elemental compositions (CcHhNnOoSsPp…) of thousands of chemical components simultaneously from accurate mass measurements (the same can be done up to 1000 Da if additional information is included). At higher mass, it becomes possible to identify proteins (including posttranslational modifications) from proteolytic peptides, as well as lipids, glycoconjugates, and other biological components. At even higher mass (˜100,000 Da or higher), it is possible to characterize posttranslational modifications of intact proteins and to map the binding surfaces of large biomolecule complexes. Here we review the principles and techniques of the highest-resolution analytical mass spectrometers (time-of-flight and Fourier transform ion cyclotron resonance and orbitrap mass analyzers) and describe some representative high-resolution applications.

Coregistration of high-resolution Mars orbital images

NASA Astrophysics Data System (ADS)

Sidiropoulos, Panagiotis; Muller, Jan-Peter

2015-04-01

The systematic orbital imaging of the Martian surface started 4 decades ago from NASA's Viking Orbiter 1 & 2 missions, which were launched in August 1975, and acquired orbital images of the planet between 1976 and 1980. The result of this reconnaissance was the first medium-resolution (i.e. ≤ 300m/pixel) global map of Mars, as well as a variety of high-resolution images (reaching up to 8m/pixel) of special regions of interest. Over the last two decades NASA has sent 3 more spacecraft with onboard instruments for high-resolution orbital imaging: Mars Global Surveyor (MGS) having onboard the Mars Orbital Camera - Narrow Angle (MOC-NA), Mars Odyssey having onboard the Thermal Emission Imaging System - Visual (THEMIS-VIS) and the Mars Reconnaissance Orbiter (MRO) having on board two distinct high-resolution cameras, Context Camera (CTX) and High-Resolution Imaging Science Experiment (HiRISE). Moreover, ESA has the multispectral High resolution Stereo Camera (HRSC) onboard ESA's Mars Express with resolution up to 12.5m since 2004. Overall, this set of cameras have acquired more than 400,000 high-resolution images, i.e. with resolution better than 100m and as fine as 25 cm/pixel. Notwithstanding the high spatial resolution of the available NASA orbital products, their accuracy of areo-referencing is often very poor. As a matter of fact, due to pointing inconsistencies, usually form errors in roll attitude, the acquired products may actually image areas tens of kilometers far away from the point that they are supposed to be looking at. On the other hand, since 2004, the ESA Mars Express has been acquiring stereo images through the High Resolution Stereo Camera (HRSC), with resolution that is usually 12.5-25 metres per pixel. The achieved coverage is more than 64% for images with resolution finer than 20 m/pixel, while for ~40% of Mars, Digital Terrain Models (DTMs) have been produced with are co-registered with MOLA [Gwinner et al., 2010]. The HRSC images and DTMs

High throughput screening of ligand binding to macromolecules using high resolution powder diffraction

DOEpatents

Von Dreele, Robert B.; D'Amico, Kevin

2006-10-31

A process is provided for the high throughput screening of binding of ligands to macromolecules using high resolution powder diffraction data including producing a first sample slurry of a selected polycrystalline macromolecule material and a solvent, producing a second sample slurry of a selected polycrystalline macromolecule material, one or more ligands and the solvent, obtaining a high resolution powder diffraction pattern on each of said first sample slurry and the second sample slurry, and, comparing the high resolution powder diffraction pattern of the first sample slurry and the high resolution powder diffraction pattern of the second sample slurry whereby a difference in the high resolution powder diffraction patterns of the first sample slurry and the second sample slurry provides a positive indication for the formation of a complex between the selected polycrystalline macromolecule material and at least one of the one or more ligands.

High-Resolution Three-Dimensional Computed Tomography for Assessing Complications Related to Intrathecal Drug Delivery.

PubMed

Morgalla, Matthias; Fortunato, Marcos; Azam, Ala; Tatagiba, Marcos; Lepski, Guillherme

2016-07-01

The assessment of the functionality of intrathecal drug delivery (IDD) systems remains difficult and time-consuming. Catheter-related problems are still very common, and sometimes difficult to diagnose. The aim of the present study is to investigate the accuracy of high-resolution three-dimensional computed tomography (CT) in order to detect catheter-related pump dysfunction. An observational, retrospective investigation. Academic medical center in Germany. We used high-resolution three dimensional (3D) computed tomography with volume rendering technique (VRT) or fluoroscopy and conventional axial-CT to assess IDD-related complications in 51 patients from our institution who had IDD systems implanted for the treatment of chronic pain or spasticity. Twelve patients (23.5%) presented a total of 22 complications. The main type of complication in our series was catheter-related (50%), followed by pump failure, infection, and inappropriate refilling. Fluoroscopy and conventional CT were used in 12 cases. High-resolution 3D CT VRT scan was used in 35 instances with suspected yet unclear complications. Using 3D-CT (VRT) the sensitivity was 58.93% - 100% (CI 95%) and the specificity 87.54% - 100% (CI 95%).The positive predictive value was 58.93% - 100% (CI 95%) and the negative predictive value: 87.54% - 100% (CI 95%).Fluoroscopy and axial CT as a combined diagnostic tool had a sensitivity of 8.3% - 91.7% (CI 95%) and a specificity of 62.9% - 100% (CI 95%). The positive predictive value was 19.29% - 100% (CI 95%) and the negative predictive value: 44.43% - 96.89% (CI 95%). This study is limited by its observational design and the small number of cases. High-resolution 3D CT VRT is a non- invasive method that can identify IDD-related complications with more precision than axial CT and fluoroscopy.

High-resolution grazing-incidence grating spectrometer for temperature measurements of low-Z ions emitting in the 100–300 Å spectral band

DOE PAGES

Widmann, K.; Beiersdorfer, P.; Magee, E. W.; ...

2014-09-19

In this paper, we have constructed a high-resolution grazing-incidence spectrometer designed for measuring the ion temperature of low-Z elements, such as Li + or Li 2 +, which radiate near 199 Å and 135 Å, respectively. Based on measurements at the Livermore Electron Beam Ion Trap we have shown that the instrumental resolution is better than 48 mÅ at the 200 Å setting and better than 40 mÅ for the 135-Å range. Such a high spectral resolution corresponds to an instrumental limit for line-width based temperature measurements of about 45 eV for the 199 Å Li+ and 65 eV formore » the 135 Å Li 2 + lines. Finally, recently obtained survey spectra from the Lithium Tokamak Experiment at the Princeton Plasma Physics Laboratory show the presence of these lithium emission lines and the expected core ion temperature of approximately 70 eV is sufficiently high to demonstrate the feasibility of utilizing our high-resolution spectrometer as an ion-temperature diagnostic.« less

Texton-based super-resolution for achieving high spatiotemporal resolution in hybrid camera system

NASA Astrophysics Data System (ADS)

Kamimura, Kenji; Tsumura, Norimichi; Nakaguchi, Toshiya; Miyake, Yoichi

2010-05-01

Many super-resolution methods have been proposed to enhance the spatial resolution of images by using iteration and multiple input images. In a previous paper, we proposed the example-based super-resolution method to enhance an image through pixel-based texton substitution to reduce the computational cost. In this method, however, we only considered the enhancement of a texture image. In this study, we modified this texton substitution method for a hybrid camera to reduce the required bandwidth of a high-resolution video camera. We applied our algorithm to pairs of high- and low-spatiotemporal-resolution videos, which were synthesized to simulate a hybrid camera. The result showed that the fine detail of the low-resolution video can be reproduced compared with bicubic interpolation and the required bandwidth could be reduced to about 1/5 in a video camera. It was also shown that the peak signal-to-noise ratios (PSNRs) of the images improved by about 6 dB in a trained frame and by 1.0-1.5 dB in a test frame, as determined by comparison with the processed image using bicubic interpolation, and the average PSNRs were higher than those obtained by the well-known Freeman’s patch-based super-resolution method. Compared with that of the Freeman’s patch-based super-resolution method, the computational time of our method was reduced to almost 1/10.

High bandwidth vapor density diagnostic system

DOEpatents

Globig, Michael A.; Story, Thomas W.

1992-01-01

A high bandwidth vapor density diagnostic system for measuring the density of an atomic vapor during one or more photoionization events. The system translates the measurements from a low frequency region to a high frequency, relatively noise-free region in the spectrum to provide improved signal to noise ratio.

Improving spatial and spectral resolution of TCV Thomson scattering

NASA Astrophysics Data System (ADS)

Hawke, J.; Andrebe, Y.; Bertizzolo, R.; Blanchard, P.; Chavan, R.; Decker, J.; Duval, B.; Lavanchy, P.; Llobet, X.; Marlétaz, B.; Marmillod, P.; Pochon, G.; Toussaint, M.

2017-12-01

The recently completed MST2 upgrade to the Thomson scattering (TS) system on TCV (Tokamak à Configuration Variable) at the Swiss Plasma Center aims to provide an enhanced spatial and spectral resolution while maintaining the high level of diagnostic flexibility for the study of TCV plasmas. The MST2 (Medium Sized Tokamak) is a work program within the Eurofusion ITER physics department, aimed at exploiting Europe's medium sized tokamak programs for a better understanding of ITER physics. This upgrade to the TCV Thomson scattering system involved the installation of 40 new compact 5-channel spectrometers and modifications to the diagnostics fiber optic design. The complete redesign of the fiber optic backplane incorporates fewer larger diameter fibers, allowing for a higher resolution in both the core and edge of TCV plasmas along the laser line, with a slight decrease in the signal to noise ratio of Thomson measurements. The 40 new spectrometers added to the system are designed to cover the full range of temperatures expected in TCV, able to measure electron temperatures (Te) with high precision between (6 eV and 20 keV) . The design of these compact spectrometers stems originally from the design utilized in the MAST (Mega Amp Spherical Tokamak) TS system located in Oxfordshire, United Kingdom. This design was implemented on TCV with an overall layout of optical fibers and spectrometers to achieve an overall increase in the spatial resolution, specifically a resolution of approximately 1% of the minor radius within the plasma pedestal region. These spectrometers also enhance the diagnostic spectral resolution, especially within the plasma edge, due to the low Te measurement capabilities. These additional spectrometers allow for a much greater diagnostic flexibility, allowing for quality full Thomson profiles in 75% of TCV plasma configurations.

High-resolution ultrasound imaging and noninvasive optoacoustic monitoring of blood variables in peripheral blood vessels

NASA Astrophysics Data System (ADS)

Petrov, Irene Y.; Petrov, Yuriy; Prough, Donald S.; Esenaliev, Rinat O.

2011-03-01

Ultrasound imaging is being widely used in clinics to obtain diagnostic information non-invasively and in real time. A high-resolution ultrasound imaging platform, Vevo (VisualSonics, Inc.) provides in vivo, real-time images with exceptional resolution (up to 30 microns) using high-frequency transducers (up to 80 MHz). Recently, we built optoacoustic systems for probing radial artery and peripheral veins that can be used for noninvasive monitoring of total hemoglobin concentration, oxyhemoglobin saturation, and concentration of important endogenous and exogenous chromophores (such as ICG). In this work we used the high-resolution ultrasound imaging system Vevo 770 for visualization of the radial artery and peripheral veins and acquired corresponding optoacoustic signals from them using the optoacoustic systems. Analysis of the optoacoustic data with a specially developed algorithm allowed for measurement of blood oxygenation in the blood vessels as well as for continuous, real-time monitoring of arterial and venous blood oxygenation. Our results indicate that: 1) the optoacoustic technique (unlike pure optical approaches and other noninvasive techniques) is capable of accurate peripheral venous oxygenation measurement; and 2) peripheral venous oxygenation is dependent on skin temperature and local hemodynamics. Moreover, we performed for the first time (to the best of our knowledge) a comparative study of optoacoustic arterial oximetry and a standard pulse oximeter in humans and demonstrated superior performance of the optoacoustic arterial oximeter, in particular at low blood flow.

Immersion Gratings for Infrared High-resolution Spectroscopy

NASA Astrophysics Data System (ADS)

Sarugaku, Yuki; Ikeda, Yuji; Kobayashi, Naoto; Kaji, Sayumi; Sukegawa, Takashi; Sugiyama, Shigeru; Nakagawa, Takao; Arasaki, Takayuki; Kondo, Sohei; Nakanishi, Kenshi; Yasui, Chikako; Kawakita, Hideyo

2016-10-01

High-resolution spectroscopy in the infrared wavelength range is essential for observations of minor isotopologues, such as HDO for water, and prebiotic organic molecules like hydrocarbons/P-bearing molecules because numerous vibrational molecular bands (including non-polar molecules) are located in this wavelength range. High spectral resolution enables us to detect weak lines without spectral line confusion. This technique has been widely used in planetary sciences, e.g., cometary coma (H2O, CO, and organic molecules), the martian atmosphere (CH4, CO2, H2O and HDO), and the upper atmosphere of gas giants (H3+ and organic molecules such as C2H6). Spectrographs with higher resolution (and higher sensitivity) still have a potential to provide a plenty of findings. However, because the size of spectrographs scales with the spectral resolution, it is difficult to realize it.Immersion grating (IG), which is a diffraction grating wherein the diffraction surface is immersed in a material with a high refractive index (n > 2), provides n times higher spectral resolution compared to a reflective grating of the same size. Because IG reduces the size of spectrograph to 1/n compared to the spectrograph with the same spectral resolution using a conventional reflective grating, it is widely acknowledged as a key optical device to realize compact spectrographs with high spectral resolution.Recently, we succeeded in fabricating a CdZnTe immersion grating with the theoretically predicted diffraction efficiency by machining process using an ultrahigh-precision five-axis processing machine developed by Canon Inc. Using the same technique, we completed a practical germanium (Ge) immersion grating with both a reflection coating on the grating surface and the an AR coating on the entrance surface. It is noteworthy that the wide wavelength range from 2 to 20 um can be covered by the two immersion gratings.In this paper, we present the performances and the applications of the immersion

HRSC: High resolution stereo camera

USGS Publications Warehouse

Neukum, G.; Jaumann, R.; Basilevsky, A.T.; Dumke, A.; Van Gasselt, S.; Giese, B.; Hauber, E.; Head, J. W.; Heipke, C.; Hoekzema, N.; Hoffmann, H.; Greeley, R.; Gwinner, K.; Kirk, R.; Markiewicz, W.; McCord, T.B.; Michael, G.; Muller, Jan-Peter; Murray, J.B.; Oberst, J.; Pinet, P.; Pischel, R.; Roatsch, T.; Scholten, F.; Willner, K.

2009-01-01

The High Resolution Stereo Camera (HRSC) on Mars Express has delivered a wealth of image data, amounting to over 2.5 TB from the start of the mapping phase in January 2004 to September 2008. In that time, more than a third of Mars was covered at a resolution of 10-20 m/pixel in stereo and colour. After five years in orbit, HRSC is still in excellent shape, and it could continue to operate for many more years. HRSC has proven its ability to close the gap between the low-resolution Viking image data and the high-resolution Mars Orbiter Camera images, leading to a global picture of the geological evolution of Mars that is now much clearer than ever before. Derived highest-resolution terrain model data have closed major gaps and provided an unprecedented insight into the shape of the surface, which is paramount not only for surface analysis and geological interpretation, but also for combination with and analysis of data from other instruments, as well as in planning for future missions. This chapter presents the scientific output from data analysis and highlevel data processing, complemented by a summary of how the experiment is conducted by the HRSC team members working in geoscience, atmospheric science, photogrammetry and spectrophotometry. Many of these contributions have been or will be published in peer-reviewed journals and special issues. They form a cross-section of the scientific output, either by summarising the new geoscientific picture of Mars provided by HRSC or by detailing some of the topics of data analysis concerning photogrammetry, cartography and spectral data analysis.

Performance of a laser frequency comb calibration system with a high-resolution solar echelle spectrograph

NASA Astrophysics Data System (ADS)

Doerr, H.-P.; Kentischer, T. J.; Steinmetz, T.; Probst, R. A.; Franz, M.; Holzwarth, R.; Udem, Th.; Hänsch, T. W.; Schmidt, W.

2012-09-01

Laser frequency combs (LFC) provide a direct link between the radio frequency (RF) and the optical frequency regime. The comb-like spectrum of an LFC is formed by exact equidistant laser modes, whose absolute optical frequencies are controlled by RF-references such as atomic clocks or GPS receivers. While nowadays LFCs are routinely used in metrological and spectroscopic fields, their application in astronomy was delayed until recently when systems became available with a mode spacing and wavelength coverage suitable for calibration of astronomical spectrographs. We developed a LFC based calibration system for the high-resolution echelle spectrograph at the German Vacuum Tower Telescope (VTT), located at the Teide observatory, Tenerife, Canary Islands. To characterize the calibration performance of the instrument, we use an all-fiber setup where sunlight and calibration light are fed to the spectrograph by the same single-mode fiber, eliminating systematic effects related to variable grating illumination.

High resolution scintillation detector with semiconductor readout

DOEpatents

Levin, Craig S.; Hoffman, Edward J.

2000-01-01

A novel high resolution scintillation detector array for use in radiation imaging such as high resolution Positron Emission Tomography (PET) which comprises one or more parallelepiped crystals with at least one long surface of each crystal being in intimate contact with a semiconductor photodetector such that photons generated within each crystal by gamma radiation passing therethrough is detected by the photodetector paired therewith.

High-Resolution Global Soil Moisture Map

NASA Image and Video Library

2015-05-19

High-resolution global soil moisture map from NASA SMAP combined radar and radiometer instruments, acquired between May 4 and May 11, 2015 during SMAP commissioning phase. The map has a resolution of 5.6 miles (9 kilometers). The data gap is due to turning the instruments on and off during testing. http://photojournal.jpl.nasa.gov/catalog/PIA19337

High-resolution DEM Effects on Geophysical Flow Models

NASA Astrophysics Data System (ADS)

Williams, M. R.; Bursik, M. I.; Stefanescu, R. E. R.; Patra, A. K.

2014-12-01

Geophysical mass flow models are numerical models that approximate pyroclastic flow events and can be used to assess the volcanic hazards certain areas may face. One such model, TITAN2D, approximates granular-flow physics based on a depth-averaged analytical model using inputs of basal and internal friction, material volume at a coordinate point, and a GIS in the form of a digital elevation model (DEM). The volume of modeled material propagates over the DEM in a way that is governed by the slope and curvature of the DEM surface and the basal and internal friction angles. Results from TITAN2D are highly dependent upon the inputs to the model. Here we focus on a single input: the DEM, which can vary in resolution. High resolution DEMs are advantageous in that they contain more surface details than lower-resolution models, presumably allowing modeled flows to propagate in a way more true to the real surface. However, very high resolution DEMs can create undesirable artifacts in the slope and curvature that corrupt flow calculations. With high-resolution DEMs becoming more widely available and preferable for use, determining the point at which high resolution data is less advantageous compared to lower resolution data becomes important. We find that in cases of high resolution, integer-valued DEMs, very high-resolution is detrimental to good model outputs when moderate-to-low (<10-15°) slope angles are involved. At these slope angles, multiple adjacent DEM cell elevation values are equal due to the need for the DEM to approximate the low slope with a limited set of integer values for elevation. The first derivative of the elevation surface thus becomes zero. In these cases, flow propagation is inhibited by these spurious zero-slope conditions. Here we present evidence for this "terracing effect" from 1) a mathematically defined simulated elevation model, to demonstrate the terracing effects of integer valued data, and 2) a real-world DEM where terracing must be

Design considerations for highly effective fluorescence excitation and detection optical systems for molecular diagnostics

NASA Astrophysics Data System (ADS)

Kasper, Axel; Van Hille, Herbert; Kuk, Sola

2018-02-01

Modern instruments for molecular diagnostics are continuously optimized for diagnostic accuracy, versatility and throughput. The latest progress in LED technology together with tailored optics solutions allows developing highly efficient photonics engines perfectly adapted to the sample under test. Super-bright chip-on-board LED light sources are a key component for such instruments providing maximum luminous intensities in a multitude of narrow spectral bands. In particular the combination of white LEDs with other narrow band LEDs allows achieving optimum efficiency outperforming traditional Xenon light sources in terms of energy consumption, heat dissipation in the system, and switching time between spectral channels. Maximum sensitivity of the diagnostic system can only be achieved with an optimized optics system for the illumination and imaging of the sample. The illumination beam path must be designed for optimum homogeneity across the field while precisely limiting the angular distribution of the excitation light. This is a necessity for avoiding spill-over to the detection beam path and guaranteeing the efficiency of the spectral filtering. The imaging optics must combine high spatial resolution, high light collection efficiency and optimized suppression of excitation light for good signal-to-noise ratio. In order to achieve minimum cross-talk between individual wells in the sample, the optics design must also consider the generation of stray light and the formation of ghost images. We discuss what parameters and limitations have to be considered in an integrated system design approach covering the full path from the light source to the detector.

High Resolution Microendoscopy for Quantitative Diagnosis of Esophageal Neoplasia

NASA Astrophysics Data System (ADS)

Shin, Dongsuk

Esophageal cancer is the eighth most common cancer in the world. Cancers of the esophagus account for 3.8% of all cases of cancers, with approximately 482,300 new cases reported in 2008 worldwide. In the United States alone, it is estimated that approximately 18,000 new cases will be diagnosed in 2013, and 15,210 deaths are expected. Despite advances in surgery and chemoradiation therapy, these advances have not led to a significant increase in survival rates, primarily because diagnosis often at an advanced and incurable stage when treatment is more difficult and less successful. Accurate, objective methods for early detection of esophageal neoplasia are needed. Here, quantitative classification algorithms for high resolution miscroendoscopic images were developed to distinguish between esophageal neoplastic and non-neoplastic tissue. A clinical study in 177 patients with esophageal squamous cell carcinoma (ESCC) was performed to evaluate the diagnostic performance of the classification algorithm in collaboration with the Mount Sinai Medical Center in the United States, the First Hospital of Jilin University in China, and the Cancer Institute and Hospital, the Chinese Academy of Medical Science in China. The study reported a sensitivity and specificity of 93% and 92%, respectively, in the training set, 87% and 97%, respectively, in the test set, and 84% and 95%, respectively, in an independent validation set. Another clinical study in 31 patients with Barrett's esophagus resulted in a sensitivity of 84% and a specificity of 85%. Finally, a compact, portable version of the high resolution microendoscopy (HRME) device using a consumer-grade camera was developed and a series of biomedical experimental studies were carried out to assess the capability of the device.

Calibration of a High Resolution X-ray Spectrometer for High-Energy-Density Plasmas on NIF

NASA Astrophysics Data System (ADS)

Kraus, B.; Gao, L.; Hill, K. W.; Bitter, M.; Efthimion, P.; Schneider, M. B.; Chen, H.; Ayers, J.; Beiersdorfer, P.; Liedahl, D.; Macphee, A. G.; Thorn, D. B.; Bettencourt, R.; Kauffman, R.; Le, H.; Nelson, D.

2017-10-01

A high-resolution, DIM-based (Diagnostic Instrument Manipulator) x-ray crystal spectrometer has been calibrated for and deployed at the National Ignition Facility (NIF) to diagnose plasma conditions and mix in ignition capsules near stagnation times. Two conical crystals in the Hall geometry focus rays from the Kr He- α, Ly- α, and He- β complexes onto a streak camera for time-resolved spectra, in order to measure electron density and temperature by observing Stark broadening and relative intensities of dielectronic satellites. Signals from these two crystals are correlated with a third crystal that time-integrates the intervening energy range. The spectrometer has been absolutely calibrated using a microfocus x-ray source, an array of CCD and single-photon-counting detectors, and K- and L-absorption edge filters. Measurements of the integrated reflectivity, energy range, and energy resolution for each crystal will be presented. The implications of the calibration on signal levels from NIF implosions and x-ray filter choices will be discussed. This work was performed under the auspices of the U.S. DoE by Princeton Plasma Physics Laboratory under contract DE-AC02-09CH11466 and by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344.

Advanced Laser-Based Techniques for Gas-Phase Diagnostics in Combustion and Aerospace Engineering.

PubMed

Ehn, Andreas; Zhu, Jiajian; Li, Xuesong; Kiefer, Johannes

2017-03-01

Gaining information of species, temperature, and velocity distributions in turbulent combustion and high-speed reactive flows is challenging, particularly for conducting measurements without influencing the experimental object itself. The use of optical and spectroscopic techniques, and in particular laser-based diagnostics, has shown outstanding abilities for performing non-intrusive in situ diagnostics. The development of instrumentation, such as robust lasers with high pulse energy, ultra-short pulse duration, and high repetition rate along with digitized cameras exhibiting high sensitivity, large dynamic range, and frame rates on the order of MHz, has opened up for temporally and spatially resolved volumetric measurements of extreme dynamics and complexities. The aim of this article is to present selected important laser-based techniques for gas-phase diagnostics focusing on their applications in combustion and aerospace engineering. Applicable laser-based techniques for investigations of turbulent flows and combustion such as planar laser-induced fluorescence, Raman and Rayleigh scattering, coherent anti-Stokes Raman scattering, laser-induced grating scattering, particle image velocimetry, laser Doppler anemometry, and tomographic imaging are reviewed and described with some background physics. In addition, demands on instrumentation are further discussed to give insight in the possibilities that are offered by laser flow diagnostics.

An Experimental High-Resolution Forecast System During the Vancouver 2010 Winter Olympic and Paralympic Games

NASA Astrophysics Data System (ADS)

Mailhot, J.; Milbrandt, J. A.; Giguère, A.; McTaggart-Cowan, R.; Erfani, A.; Denis, B.; Glazer, A.; Vallée, M.

2014-01-01

Environment Canada ran an experimental numerical weather prediction (NWP) system during the Vancouver 2010 Winter Olympic and Paralympic Games, consisting of nested high-resolution (down to 1-km horizontal grid-spacing) configurations of the GEM-LAM model, with improved geophysical fields, cloud microphysics and radiative transfer schemes, and several new diagnostic products such as density of falling snow, visibility, and peak wind gust strength. The performance of this experimental NWP system has been evaluated in these winter conditions over complex terrain using the enhanced mesoscale observing network in place during the Olympics. As compared to the forecasts from the operational regional 15-km GEM model, objective verification generally indicated significant added value of the higher-resolution models for near-surface meteorological variables (wind speed, air temperature, and dewpoint temperature) with the 1-km model providing the best forecast accuracy. Appreciable errors were noted in all models for the forecasts of wind direction and humidity near the surface. Subjective assessment of several cases also indicated that the experimental Olympic system was skillful at forecasting meteorological phenomena at high-resolution, both spatially and temporally, and provided enhanced guidance to the Olympic forecasters in terms of better timing of precipitation phase change, squall line passage, wind flow channeling, and visibility reduction due to fog and snow.

High-resolution myocardial stress perfusion at 3 T in patients with suspected coronary artery disease.

PubMed

Meyer, Carsten; Strach, Katharina; Thomas, Daniel; Litt, Harold; Nähle, Claas P; Tiemann, Klaus; Schwenger, Ulrich; Schild, Hans H; Sommer, Torsten

2008-02-01

To implement a high-resolution first-pass myocardial perfusion imaging protocol (HRPI) at 3 T, and to evaluate the feasibility, image quality and accuracy of this approach prospectively in patients with suspected CAD. We hypothesized that utilizing the gain in SNR at 3 T to increase spatial resolution would reduce partial volume effects and subendocardial dark rim artifacts in comparison to 1.5 T. HRPI studies were performed on 60 patients using a segmented k-space gradient echo sequence (in plane resolution 1.97 x 1.94 mm(2)). Semiquantitative assessment of dark rim artifacts was performed for the stress studies on a slice-by-slice basis. Qualitative visual analysis was compared to quantitative coronary angiography (QCA) results; hemodynamically significant CAD was defined as stenosis >or=70% at QCA. Dark rim artifacts appeared in 108 of 180 slices (average extent 1.3 +/- 1.2 mm representing 11.8 +/- 10.8% of the transmural myocardial thickness). Sensitivity, specifity, and test accuracy for the detection of significant CAD were 89%,79%, and 85%. HRPI studies at 3 T are feasible in a clinical setting, providing good image quality and high accuracy for detection of significant CAD. The presence of dark rim artifacts does not appear to represent a diagnostic problem when using a HRPI approach.

Non-invasive spectroscopic techniques in the diagnosis of non-melanoma skin cancer

NASA Astrophysics Data System (ADS)

Drakaki, E.; Sianoudis, IA; Zois, EN; Makropoulou, M.; Serafetinides, AA; Dessinioti, C.; Stefanaki, E.; Stratigos, AJ; Antoniou, C.; Katsambas, A.; Christofidou, E.

2017-11-01

The number of non-melanoma skin cancers is increasing worldwide and has become an important health and economic issue. Early detection and treatment of skin cancer can significantly improve patient outcome. Therefore there is an increase in the demand for proper management and effective non-invasive diagnostic modalities in order to avoid relapses or unnecessary treatments. Although the gold standard of diagnosis for non-melanoma skin cancers is biopsy followed by histopathology evaluation, optical non-invasive diagnostic tools have obtained increased attention. Emerging non-invasive or minimal invasive techniques with possible application in the diagnosis of non-melanoma skin cancers include high-definition optical coherence tomography, fluorescence spectroscopy, oblique incidence diffuse reflectance spectrometry among others spectroscopic techniques. Our findings establish how those spectrometric techniques can be used to more rapidly and easily diagnose skin cancer in an accurate and automated manner in the clinic.

High resolution gamma-ray spectroscopy and the fascinating angular momentum realm of the atomic nucleus

NASA Astrophysics Data System (ADS)

Riley, M. A.; Simpson, J.; Paul, E. S.

2016-12-01

In 1974 Aage Bohr and Ben Mottelson predicted the different ‘phases’ that may be expected in deformed nuclei as a function of increasing angular momentum and excitation energy all the way up to the fission limit. While admitting their picture was highly conjectural they confidently stated ‘...with the ingenious experimental approaches that are being developed, we may look forward with excitement to the detailed spectroscopic studies that will illuminate the behaviour of the spinning quantised nucleus’. High resolution gamma-ray spectroscopy has indeed been a major tool in studying the structure of atomic nuclei and has witnessed numerous significant advances over the last four decades. This article will select highlights from investigations at the Niels Bohr Institute, Denmark, and Daresbury Laboratory, UK, in the late 1970s and early 1980s, some of which have continued at other national laboratories in Europe and the USA to the present day. These studies illustrate the remarkable diversity of phenomena and symmetries exhibited by nuclei in the angular momentum-excitation energy plane that continue to surprise and fascinate scientists.

Characterization of High Ge Content SiGe Heterostructures and Graded Alloy Layers Using Spectroscopic Ellipsometry

NASA Technical Reports Server (NTRS)

Heyd, A. R.; Alterovitz, S. A.; Croke, E. T.

1995-01-01

Si(x)Ge(1-x)heterostructures on Si substrates have been widely studied due to the maturity of Si technology. However, work on Si(x)Ge)1-x) heterostructures on Ge substrates has not received much attention. A Si(x)Ge(1-x) layer on a Si substrate is under compressive strain while Si(x)Ge(1-x) on Ge is under tensile strain; thus the critical points will behave differently. In order to accurately characterize high Ge content Si(x)Ge(1-x) layers the energy shift algorithm used to calculate alloy compositions, has been modified. These results have been used along with variable angle spectroscopic ellipsometry (VASE) measurements to characterize Si(x)Ge(1-x)/Ge superlattices grown on Ge substrates. The results agree closely with high resolution x-ray diffraction measurements made on the same samples. The modified energy shift algorithm also allows the VASE analysis to be upgraded in order to characterize linearly graded layers. In this work VASE has been used to characterize graded Si(x)Ge(1-x) layers in terms of the total thickness, and the start and end alloy composition. Results are presented for a 1 micrometer Si(x)Ge(1-x) layer linearly graded in the range 0.5 less than or equal to x less than or equal to 1.0.

A new concept of efficient therapeutic drug monitoring using the high-resolution continuum source absorption spectrometry and the surface enhanced Raman spectroscopy

NASA Astrophysics Data System (ADS)

Xing, Yanlong; Fuss, Harald; Lademann, Jürgen; Huang, Mao Dong; Becker-Ross, Helmut; Florek, Stefan; Patzelt, Alexa; Meinke, Martina C.; Jung, Sora; Esser, Norbert

2018-04-01

In this study, a new therapeutic drug monitoring approach has been tested based on the combination of CaF molecular absorption using high-resolution continuum source absorption spectrometry (HR-CSAS) and surface enhanced Raman spectroscopy (SERS). HR-CSAS with mini graphite tube was successfully tested for clinical therapeutic drug monitoring of the fluorine-containing drug capecitabine in sweat samples of cancer patients: It showed advantageous features of high selectivity (no interference from Cl), high sensitivity (characteristic mass of 0.1 ng at CaF 583.069 nm), low sample consumption (down to 30 nL) and fast measurement (no sample pretreatment and less than 1 min of responding time) in tracing the fluorine signal out of capecitabine. However, this technique has the disadvantage of the total loss of the drug's structure information after burning the sample at very high temperature. Therefore, a new concept of combining HR-CSAS with a non-destructive spectroscopic method (SERS) was proposed for the sensitive sensing and specific identification of capecitabine. We tested and succeed in obtaining the molecular characteristics of the metabolite of capecitabine (named 5-fluorouracil) by the non-destructive SERS technique. With the results shown in this work, it is demonstrated that the combined spectroscopic technique of HR-CSAS and SERS will be very useful in efficient therapeutic drug monitoring in the future.

High-sensitivity Leak-testing Method with High-Resolution Integration Technique

NASA Astrophysics Data System (ADS)

Fujiyoshi, Motohiro; Nonomura, Yutaka; Senda, Hidemi

A high-resolution leak-testing method named HR (High-Resolution) Integration Technique has been developed for MEMS (Micro Electro Mechanical Systems) sensors such as a vibrating angular-rate sensor housed in a vacuum package. Procedures of the method to obtain high leak-rate resolution were as follows. A package filled with helium gas was kept in a small accumulation chamber to accumulate helium gas leaking from the package. After the accumulation, the accumulated helium gas was introduced into a mass spectrometer in a short period of time, and the flux of the helium gas was measured by the mass spectrometer as a transient phenomenon. The leak-rate of the package was calculated from the detected transient waveform of the mass spectrometer and the accumulation time of the helium gas in the accumulation chamber. Because the density of the helium gas in the vacuum chamber increased and the accumulated helium gas was measured in a very short period of time with the mass spectrometer, the peak strength of the transient waveform became high and the signal to noise ratio was much improved. The detectable leak-rate resolution of the technique reached 1×10-15 (Pa·m3/s). This resolution is 103 times superior to that of the conventional helium vacuum integration method. The accuracy of the measuring system was verified with a standard helium gas leak source. The results were well matched between theoretical calculation based on the leak-rate of the source and the experimental results within only 2% error.