Science.gov

Sample records for higher order structures

  1. Generalized structure of higher order nonclassicality

    NASA Astrophysics Data System (ADS)

    Verma, Amit; Pathak, Anirban

    2010-02-01

    A generalized notion of higher order nonclassicality (in terms of higher order moments) is introduced. Under this generalized framework of higher order nonclassicality, conditions of higher order squeezing and higher order subpoissonian photon statistics are derived. A simpler form of the Hong-Mandel higher order squeezing criterion is derived under this framework by using an operator ordering theorem introduced by us in [A. Pathak, J. Phys. A 33 (2000) 5607]. It is also generalized for multi-photon Bose operators of Brandt and Greenberg. Similarly, condition for higher order subpoissonian photon statistics is derived by normal ordering of higher powers of number operator. Further, with the help of simple density matrices, it is shown that the higher order antibunching (HOA) and higher order subpoissonian photon statistics (HOSPS) are not the manifestation of the same phenomenon and consequently it is incorrect to use the condition of HOA as a test of HOSPS. It is also shown that the HOA and HOSPS may exist even in absence of the corresponding lower order phenomenon. Binomial state, nonlinear first order excited squeezed state (NLESS) and nonlinear vacuum squeezed state (NLVSS) are used as examples of quantum state and it is shown that these states may show higher order nonclassical characteristics. It is observed that the Binomial state which is always antibunched, is not always higher order squeezed and NLVSS which shows higher order squeezing does not show HOSPS and HOA. The opposite is observed in NLESS and consequently it is established that the HOSPS and HOS are two independent signatures of higher order nonclassicality.

  2. Chromatin Higher-order Structure and Dynamics

    PubMed Central

    Woodcock, Christopher L.; Ghosh, Rajarshi P.

    2010-01-01

    The primary role of the nucleus as an information storage, retrieval, and replication site requires the physical organization and compaction of meters of DNA. Although it has been clear for many years that nucleosomes constitute the first level of chromatin compaction, this contributes a relatively small fraction of the condensation needed to fit the typical genome into an interphase nucleus or set of metaphase chromosomes, indicating that there are additional “higher order” levels of chromatin condensation. Identifying these levels, their interrelationships, and the principles that govern their occurrence has been a challenging and much discussed problem. In this article, we focus on recent experimental advances and the emerging evidence indicating that structural plasticity and chromatin dynamics play dominant roles in genome organization. We also discuss novel approaches likely to yield important insights in the near future, and suggest research areas that merit further study. PMID:20452954

  3. Chromatin higher-order structures and gene regulation

    PubMed Central

    Li, Guohong

    2011-01-01

    Genomic DNA in the eukaryotic nucleus is hierarchically packaged by histones into chromatin to fit inside the nucleus. The dynamics of higher-order chromatin compaction play a critical role in transcription and other biological processes inherent to DNA. Many factors, including histone variants, histone modifications, DNA methylation and the binding of non-histone architectural proteins regulate the structure of chromatin. Although the structure of nucleosomes, the fundamental repeating unit of chromatin, is clear, there is still much discussion on the higher-order levels of chromatin structure. In this review, we focus on the recent progress in elucidating the structure of the 30-nm chromatin fiber. We also discuss the structural plasticity/dynamics and epigenetic inheritance of higher-order chromatin and the roles of chromatin higher-order organization in eukaryotic gene regulation. PMID:21342762

  4. Symplectic structures related with higher order variational problems

    NASA Astrophysics Data System (ADS)

    Kijowski, Jerzy; Moreno, Giovanni

    2015-06-01

    In this paper, we derive the symplectic framework for field theories defined by higher order Lagrangians. The construction is based on the symplectic reduction of suitable spaces of iterated jets. The possibility of reducing a higher order system of partial differential equations to a constrained first-order one, the symplectic structures naturally arising in the dynamics of a first-order Lagrangian theory, and the importance of the Poincaré-Cartan form for variational problems, are all well-established facts. However, their adequate combination corresponding to higher order theories is missing in the literature. Here we obtain a consistent and truly finite-dimensional canonical formalism, as well as a higher order version of the Poincaré-Cartan form. In our exposition, the rigorous global proofs of the main results are always accompanied by their local coordinate descriptions, indispensable to work out practical examples.

  5. Higher-order structure of rRNA

    NASA Technical Reports Server (NTRS)

    Gutell, R. R.; Woese, C. R.

    1986-01-01

    A comparative search for phylogenetically covarying basepair replacements within potential helices has been the only reliable method to determine the correct secondary structure of the 3 rRNAs, 5S, 16S, and 23S. The analysis of 16S from a wide phylogenetic spectrum, that includes various branches of the eubacteria, archaebacteria, eucaryotes, in addition to the mitochondria and chloroplast, is beginning to reveal the constraints on the secondary structures of these rRNAs. Based on the success of this analysis, and the assumption that higher order structure will also be phylogenetically conserved, a comparative search was initiated for positions that show co-variation not involved in secondary structure helices. From a list of potential higher order interactions within 16S rRNA, two higher-order interactions are presented. The first of these interactions involves positions 570 and 866. Based on the extent of phylogenetic covariation between these positions while maintaining Watson-Crick pairing, this higher-order interaction is considered proven. The other interaction involves a minimum of six positions between the 1400 and 1500 regions of the 16S rRNA. Although these patterns of covariation are not as striking as the 570/866 interaction, the fact that they all exist in an anti-parallel fashion and that experimental methods previously implicated these two regions of the molecule in tRNA function suggests that these interactions be given serious consideration.

  6. Stable static structures in models with higher-order derivatives

    SciTech Connect

    Bazeia, D.; Lobão, A.S.; Menezes, R.

    2015-09-15

    We investigate the presence of static solutions in generalized models described by a real scalar field in four-dimensional space–time. We study models in which the scalar field engenders higher-order derivatives and spontaneous symmetry breaking, inducing the presence of domain walls. Despite the presence of higher-order derivatives, the models keep to equations of motion second-order differential equations, so we focus on the presence of first-order equations that help us to obtain analytical solutions and investigate linear stability on general grounds. We then illustrate the general results with some specific examples, showing that the domain wall may become compact and that the zero mode may split. Moreover, if the model is further generalized to include k-field behavior, it may contribute to split the static structure itself.

  7. Higher-order structure of Saccharomyces cerevisiae chromatin

    SciTech Connect

    Lowary, P.T.; Widom, J. )

    1989-11-01

    We have developed a method for partially purifying chromatin from Saccharomyces cerevisiae (baker's yeast) to a level suitable for studies of its higher-order folding. This has required the use of yeast strains that are free of the ubiquitous yeast killer virus. Results from dynamic light scattering, electron microscopy, and x-ray diffraction show that the yeast chromatin undergoes a cation-dependent folding into 30-nm filaments that resemble those characteristic of higher-cell chromatin; moreover, the packing of nucleosomes within the yeast 30-nm filaments is similar to that of higher cells. These results imply that yeast has a protein or protein domain that serves the role of the histone H 1 found in higher cells; physical and genetic studies of the yeast activity could help elucidate the structure and function of H 1. Images of the yeast 30-nm filaments can be used to test crossed-linker models for 30-nm filament structure.

  8. Revealing Higher Order Protein Structure Using Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Chait, Brian T.; Cadene, Martine; Olinares, Paul Dominic; Rout, Michael P.; Shi, Yi

    2016-04-01

    The development of rapid, sensitive, and accurate mass spectrometric methods for measuring peptides, proteins, and even intact protein assemblies has made mass spectrometry (MS) an extraordinarily enabling tool for structural biology. Here, we provide a personal perspective of the increasingly useful role that mass spectrometric techniques are exerting during the elucidation of higher order protein structures. Areas covered in this brief perspective include MS as an enabling tool for the high resolution structural biologist, for compositional analysis of endogenous protein complexes, for stoichiometry determination, as well as for integrated approaches for the structural elucidation of protein complexes. We conclude with a vision for the future role of MS-based techniques in the development of a multi-scale molecular microscope.

  9. Revealing Higher Order Protein Structure Using Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Chait, Brian T.; Cadene, Martine; Olinares, Paul Dominic; Rout, Michael P.; Shi, Yi

    2016-06-01

    The development of rapid, sensitive, and accurate mass spectrometric methods for measuring peptides, proteins, and even intact protein assemblies has made mass spectrometry (MS) an extraordinarily enabling tool for structural biology. Here, we provide a personal perspective of the increasingly useful role that mass spectrometric techniques are exerting during the elucidation of higher order protein structures. Areas covered in this brief perspective include MS as an enabling tool for the high resolution structural biologist, for compositional analysis of endogenous protein complexes, for stoichiometry determination, as well as for integrated approaches for the structural elucidation of protein complexes. We conclude with a vision for the future role of MS-based techniques in the development of a multi-scale molecular microscope.

  10. Revealing Higher Order Protein Structure Using Mass Spectrometry.

    PubMed

    Chait, Brian T; Cadene, Martine; Olinares, Paul Dominic; Rout, Michael P; Shi, Yi

    2016-06-01

    The development of rapid, sensitive, and accurate mass spectrometric methods for measuring peptides, proteins, and even intact protein assemblies has made mass spectrometry (MS) an extraordinarily enabling tool for structural biology. Here, we provide a personal perspective of the increasingly useful role that mass spectrometric techniques are exerting during the elucidation of higher order protein structures. Areas covered in this brief perspective include MS as an enabling tool for the high resolution structural biologist, for compositional analysis of endogenous protein complexes, for stoichiometry determination, as well as for integrated approaches for the structural elucidation of protein complexes. We conclude with a vision for the future role of MS-based techniques in the development of a multi-scale molecular microscope. Graphical Abstract ᅟ. PMID:27080007

  11. Neutron scattering studies on chromatin higher-order structure

    SciTech Connect

    Graziano, V.; Gerchman, S.E.; Schneider, D.K.; Ramakrishnan, V.

    1994-12-31

    We have been engaged in studies of the structure and condensation of chromatin into the 30nm filament using small-angle neutron scattering. We have also used deuterated histone H1 to determine its location in the chromatin 30nm filament. Our studies indicate that chromatin condenses with increasing ionic strength to a limiting structure that has a mass per unit length of 6-7 nucleosomes/11 nm. They also show that the linker histone H1/H5 is located in the interior of the chromatin filament, in a position compatible with its binding to the inner face of the nucleosome. Analysis of the mass per unit length as a function of H5 stoichiometry suggests that 5-7 contiguous nucleosomes need to have H5 bound before a stable higher order structure can exist.

  12. Technical decision making with higher order structure data: higher order structure characterization during protein therapeutic candidate screening.

    PubMed

    Jiang, Yijia; Li, Cynthia; Li, Jenny; Gabrielson, John P; Wen, Jie

    2015-04-01

    Protein therapeutics differ considerably from small molecule drugs because of the presence of higher order structure (HOS), post-translational modifications, inherent molecular heterogeneity, and unique stability profiles. At early stages of development, multiple molecular candidates are often produced for the same biological target. In order to select the most promising molecule for further development, studies are carried out to compare and rank order the candidates in terms of their manufacturability, purity, and stability profiles. This note reports a case study on the use of selected HOS characterization methods for candidate selection and the role of HOS data in identifying potential challenges that may be avoided by selecting the optimal molecular entity for continued development. PMID:25716705

  13. Higher order structure of proteins solubilized in AOT reverse micelles.

    PubMed

    Naoe, Kazumitsu; Noda, Kazuki; Kawagoe, Mikio; Imai, Masanao

    2004-11-15

    The higher order structure of proteins solubilized in an bis(2-ethylhexyl) sulfosuccinate sodium (AOT) reverse micellar system was investigated. From circular dichroic (CD) measurement, CD spectra of cytochrome c, which is solubilized at the interface of reverse micelles, markedly changed on going from buffer solution to the reverse micellar solution, and the ellipticity values in the far- and near-UV regions decreased with decreasing the water content (W0: molar ratio of water to AOT), indicating that the secondary and tertiary structures of cytochrome c changed with the water content. The ellipticity of ribonuclease A, which is solubilized in the center of micellar water pool, in the near-UV region was dependent on W0 and became minimum when W0 of ca. 8 while the ellipticity in the far-UV region was almost constant, indicating that the tertiary structure of ribonuclease A was affected by the water content, but the secondary structure was conserved. The degree of curvature of the micellar interface appears to influence the protein structure because the reverse micelle size is linearly proportional to the W0 value. As evidence of this, when the micelle size was comparable to the protein's dimensions, the structures were more affected by the water content. Judging from the dependence of the factor influencing the protein structure on the protein species, the location of solubilized protein in reverse micelles is significantly related to whether the protein structure in the system is affected by the micellar interface. In the cases of cytochrome c and lysozyme, the ellipticity against W0 was dependent on the AOT concentration. In contrast, ribonuclease A gave very similar ellipticity values whatever the AOT concentration. In the n-hexane micellar system, cytochrome c exhibited lower ellipticity values and ribonuclease A in the lower W0 range (W0higher ellipticity values. These results indicated that the interaction between the protein and the micellar

  14. MJO structure associated with the higher-order CEOF modes

    NASA Astrophysics Data System (ADS)

    Liu, Ping

    2014-10-01

    the total 432 CEOF modes retain all variance of the baseline MJO, while those higher than 10 contain less information and more noise and can be discarded. Furthermore, this study indicated that the longitudinal STD of the reconstructed anomalies detects the MJO phases and magnitudes in the western Pacific with more physical meaning and in better agreement with the Hovmöller diagrams than the RMM-like amplitude. The results provide an integral figure of the MJO structure from the CEOF analysis and a more robust RMM framework for monitoring the MJO's evolution in real time and for validating its numerical forecast and simulations.

  15. Higher order structures of the caseins: a paradox?

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This book chapter deals with the molecular architecture of the major milk proteins, the caseins. Earlier theories of casein structure classified them as random coils; i.e., flexible without definite structural elements. Recent advances in the field of protein chemistry have significantly enhanced ...

  16. The Structure of Higher Education: Order in the Academy

    ERIC Educational Resources Information Center

    Smith, Clair A.

    2009-01-01

    Higher education in the U.S. is provided by an interesting mix of public, private non-profit, and for-profit institutions. The for-profit educational firm serves the residual claimant owners and has the greatest incentive for efficient operation. The public and private non-profit schools have less efficient incentives, but benefit from charitable…

  17. Higher order chromatin structure: bridging physics and biology

    PubMed Central

    Fudenberg, Geoffrey; Mirny, Leonid A.

    2012-01-01

    Recent advances in microscopy and genomic techniques have provided new insight into spatial chromatin organization inside of the nucleus. In particular, chromosome conformation capture data has highlighted the relevance of polymer physics for high-order chromatin organization. In this context, we review basic polymer states, discuss how an appropriate polymer model can be determined from experimental data, and examine the success and limitations of various polymer models of high-order interphase chromatin organization. By taking into account topological constraints acting on the chromatin fiber, recently-developed polymer models of interphase chromatin can reproduce the observed scaling of distances between genomic loci, chromosomal territories, and probabilities of contacts between loci measured by chromosome conformation capture methods. Polymer models provide a framework for the interpretation of experimental data as ensembles of conformations rather than collections of loops, and will be crucial for untangling functional implications of chromosomal organization. PMID:22360992

  18. Simple NMR methods for evaluating higher order structures of monoclonal antibody therapeutics with quinary structure.

    PubMed

    Chen, Kang; Long, Dianna S; Lute, Scott C; Levy, Michaella J; Brorson, Kurt A; Keire, David A

    2016-09-01

    Monoclonal antibody (mAb) drugs constitute the largest class of protein therapeutics currently on the market. Correctly folded protein higher order structure (HOS), including quinary structure, is crucial for mAb drug quality. The quinary structure is defined as the association of quaternary structures (e.g., oligomerized mAb). Here, several commonly available analytical methods, i.e., size-exclusion-chromatography (SEC) FPLC, multi-angle light scattering (MALS), circular dichroism (CD), NMR and multivariate analysis, were combined and modified to yield a complete profile of HOS and comparable metrics. Rituximab and infliximab were chosen for method evaluation because both IgG1 molecules are known to be homologous in sequence, superimposable in Fab crystal structure and identical in Fc structure. However, herein the two are identified to be significantly different in quinary structure in addition to minor secondary structure differences. All data collectively showed rituximab was mostly monomeric while infliximab was in mono-oligomer equilibrium driven by its Fab fragment. The quinary structure differences were qualitatively inferred from the less used but more reproducible dilution-injection-SEC-FPLC curve method. Quantitative principal component analysis (PCA) was performed on NMR spectra of either the intact or the in-situ enzymatic-digested mAb samples. The cleavage reactions happened directly in NMR tubes without further separation, which greatly enhanced NMR spectra quality and resulted in larger inter- and intra-lot variations based on PCA. The new in-situ enzymatic digestion method holds potential in identifying structural differences on larger therapeutic molecules using NMR. PMID:27344629

  19. The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules.

    PubMed

    Wu, Hao; Fuxreiter, Monika

    2016-05-19

    We here attempt to achieve an integrated understanding of the structure and dynamics of a number of higher-order assemblies, including amyloids, various kinds of signalosomes, and cellular granules. We propose that the synergy between folded domains, linear motifs, and intrinsically disordered regions regulates the formation and intrinsic fuzziness of all higher-order assemblies, creating a structural and dynamic continuum. We describe how such regulatory mechanisms could be influenced under pathological conditions. PMID:27203110

  20. Development of higher-order modal methods for transient thermal and structural analysis

    NASA Technical Reports Server (NTRS)

    Camarda, Charles J.; Haftka, Raphael T.

    1989-01-01

    A force-derivative method which produces higher-order modal solutions to transient problems is evaluated. These higher-order solutions converge to an accurate response using fewer degrees-of-freedom (eigenmodes) than lower-order methods such as the mode-displacement or mode-acceleration methods. Results are presented for non-proportionally damped structural problems as well as thermal problems modeled by finite elements.

  1. Factors Affecting Higher Order Thinking Skills of Students: A Meta-Analytic Structural Equation Modeling Study

    ERIC Educational Resources Information Center

    Budsankom, Prayoonsri; Sawangboon, Tatsirin; Damrongpanit, Suntorapot; Chuensirimongkol, Jariya

    2015-01-01

    The purpose of the research is to develop and identify the validity of factors affecting higher order thinking skills (HOTS) of students. The thinking skills can be divided into three types: analytical, critical, and creative thinking. This analysis is done by applying the meta-analytic structural equation modeling (MASEM) based on a database of…

  2. Divergence of Mammalian Higher Order Chromatin Structure Is Associated with Developmental Loci

    PubMed Central

    Chambers, Emily V.; Bickmore, Wendy A.; Semple, Colin A.

    2013-01-01

    Several recent studies have examined different aspects of mammalian higher order chromatin structure – replication timing, lamina association and Hi-C inter-locus interactions — and have suggested that most of these features of genome organisation are conserved over evolution. However, the extent of evolutionary divergence in higher order structure has not been rigorously measured across the mammalian genome, and until now little has been known about the characteristics of any divergent loci present. Here, we generate a dataset combining multiple measurements of chromatin structure and organisation over many embryonic cell types for both human and mouse that, for the first time, allows a comprehensive assessment of the extent of structural divergence between mammalian genomes. Comparison of orthologous regions confirms that all measurable facets of higher order structure are conserved between human and mouse, across the vast majority of the detectably orthologous genome. This broad similarity is observed in spite of many loci possessing cell type specific structures. However, we also identify hundreds of regions (from 100 Kb to 2.7 Mb in size) showing consistent evidence of divergence between these species, constituting at least 10% of the orthologous mammalian genome and encompassing many hundreds of human and mouse genes. These regions show unusual shifts in human GC content, are unevenly distributed across both genomes, and are enriched in human subtelomeric regions. Divergent regions are also relatively enriched for genes showing divergent expression patterns between human and mouse ES cells, implying these regions cause divergent regulation. Particular divergent loci are strikingly enriched in genes implicated in vertebrate development, suggesting important roles for structural divergence in the evolution of mammalian developmental programmes. These data suggest that, though relatively rare in the mammalian genome, divergence in higher order chromatin

  3. HIGHER ORDER FACTOR STRUCTURE OF THE WISC-IV IN A CLINICAL NEUROPSYCHOLOGICAL SAMPLE

    PubMed Central

    Bodin, Doug; Pardini, Dustin A.; Burns, Thomas G.; Stevens, Abigail B.

    2010-01-01

    A confirmatory factor analysis was conducted examining the higher order factor structure of the WISC-IV scores for 344 children who participated in neuropsychological evaluations at a large children’s hospital. The WISC-IV factor structure mirrored that of the standardization sample. The second order general intelligence factor (g) accounted for the largest proportion of variance in the first-order latent factors and in the individual subtests, especially for the working memory index. The first-order processing speed factor exhibited the most unique variance beyond the influence of g. The results suggest that clinicians should not ignore the contribution of g when interpreting the first-order factors. PMID:19132580

  4. The post-mitotic state in neurons correlates with a stable nuclear higher-order structure.

    PubMed

    Aranda-Anzaldo, Armando

    2012-03-01

    Neurons become terminally differentiated (TD) post-mitotic cells very early during development yet they may remain alive and functional for decades. TD neurons preserve the molecular machinery necessary for DNA synthesis that may be reactivated by different stimuli but they never complete a successful mitosis. The non-reversible nature of the post-mitotic state in neurons suggests a non-genetic basis for it since no set of mutations has been able to revert it. Comparative studies of the nuclear higher-order structure in neurons and cells with proliferating potential suggest that the non-reversible nature of the post-mitotic state in neurons has a structural basis in the stability of the nuclear higher-order structure. PMID:22808316

  5. Technical decision-making with higher order structure data: specific binding of a nonionic detergent perturbs higher order structure of a therapeutic monoclonal antibody.

    PubMed

    Budyak, Ivan L; Doyle, Brandon L; Weiss, William F

    2015-04-01

    Robust higher order structure (HOS) characterization capability and strategy are critical throughout biopharmaceutical development from initial candidate selection and formulation screening to process optimization and manufacturing. This case study describes the utility of several orthogonal HOS methods as investigational tools during purification process development. An atypically high level of residual detergent in a development drug substance batch of a therapeutic monoclonal antibody triggered a root cause investigation. Several orthogonal biophysical techniques were used to uncover and characterize a specific interaction between the detergent and the antibody. Isothermal titration calorimetry (ITC) was used to quantify the molar ratio and affinity of the binding event, and circular dichroism (CD) spectroscopy and differential scanning calorimetry (DSC) were used to evaluate corresponding impacts on secondary/tertiary structure and thermal stability, respectively. As detergents are used routinely in biopharmaceutical processing, this case study highlights the value and power of HOS data in informing technical investigations and underlines the importance of HOS characterization as a component of overall biopharmaceutical analytical control strategy. PMID:25545760

  6. The role of Bni5 in the regulation of septin higher-order structure formation.

    PubMed

    Patasi, Csilla; Godočíková, Jana; Michlíková, Soňa; Nie, Yan; Káčeriková, Radka; Kválová, Katarína; Raunser, Stefan; Farkašovský, Marian

    2015-12-01

    Septins are a family of conserved cytoskeletal proteins playing an essential role in cytokinesis and in many other cellular processes in fungi and animals. In budding yeast Saccharomyces cerevisiae, septins form filaments and higher-order structures at the mother-bud neck depending on the particular stage of the cell cycle. Septin structures at the division plane serve as a scaffold to recruit the proteins required for particular cellular processes. The formation and localization of septin structures at particular stages of the cell cycle also determine functionality of these proteins. Many different proteins participate in regulating septin assembly. Despite recent developments, we are only beginning to understand how specific protein-protein interactions lead to changes in the polymerization of septin filaments or assembly of higher-order structures. Here, using fluorescence and electron microscopy, we found that Bni5 crosslinks septin filaments into networks by bridging pairs or multiple filaments, forming structures that resemble railways. Furthermore, Bni5 appears to be a substrate of the Elm1 protein kinase in vitro. Moreover, Elm1 induces in the presence of Bni5 disassembly of long septin filaments, suggesting that these proteins may participate in the hourglass to double ring transition. This work gives new insight into the regulatory role of Bni5 in the structural changes of septins. PMID:26351911

  7. Structure-Specific Ribonucleases for MS-Based Elucidation of Higher-Order RNA Structure

    NASA Astrophysics Data System (ADS)

    Scalabrin, Matteo; Siu, Yik; Asare-Okai, Papa Nii; Fabris, Daniele

    2014-07-01

    Supported by high-throughput sequencing technologies, structure-specific nucleases are experiencing a renaissance as biochemical probes for genome-wide mapping of nucleic acid structure. This report explores the benefits and pitfalls of the application of Mung bean (Mb) and V1 nuclease, which attack specifically single- and double-stranded regions of nucleic acids, as possible structural probes to be employed in combination with MS detection. Both enzymes were found capable of operating in ammonium-based solutions that are preferred for high-resolution analysis by direct infusion electrospray ionization (ESI). Sequence analysis by tandem mass spectrometry (MS/MS) was performed to confirm mapping assignments and to resolve possible ambiguities arising from the concomitant formation of isobaric products with identical base composition and different sequences. The observed products grouped together into ladder-type series that facilitated their assignment to unique regions of the substrate, but revealed also a certain level of uncertainty in identifying the boundaries between paired and unpaired regions. Various experimental factors that are known to stabilize nucleic acid structure, such as higher ionic strength, presence of Mg(II), etc., increased the accuracy of cleavage information, but did not completely eliminate deviations from expected results. These observations suggest extreme caution in interpreting the results afforded by these types of reagents. Regardless of the analytical platform of choice, the results highlighted the need to repeat probing experiments under the most diverse possible conditions to recognize potential artifacts and to increase the level of confidence in the observed structural information.

  8. RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure.

    PubMed

    Lu, Zhipeng; Zhang, Qiangfeng Cliff; Lee, Byron; Flynn, Ryan A; Smith, Martin A; Robinson, James T; Davidovich, Chen; Gooding, Anne R; Goodrich, Karen J; Mattick, John S; Mesirov, Jill P; Cech, Thomas R; Chang, Howard Y

    2016-05-19

    RNA has the intrinsic property to base pair, forming complex structures fundamental to its diverse functions. Here, we develop PARIS, a method based on reversible psoralen crosslinking for global mapping of RNA duplexes with near base-pair resolution in living cells. PARIS analysis in three human and mouse cell types reveals frequent long-range structures, higher-order architectures, and RNA-RNA interactions in trans across the transcriptome. PARIS determines base-pairing interactions on an individual-molecule level, revealing pervasive alternative conformations. We used PARIS-determined helices to guide phylogenetic analysis of RNA structures and discovered conserved long-range and alternative structures. XIST, a long noncoding RNA (lncRNA) essential for X chromosome inactivation, folds into evolutionarily conserved RNA structural domains that span many kilobases. XIST A-repeat forms complex inter-repeat duplexes that nucleate higher-order assembly of the key epigenetic silencing protein SPEN. PARIS is a generally applicable and versatile method that provides novel insights into the RNA structurome and interactome. VIDEO ABSTRACT. PMID:27180905

  9. ANOVA-HDMR structure of the higher order nodal diffusion solution

    SciTech Connect

    Bokov, P. M.; Prinsloo, R. H.; Tomasevic, D. I.

    2013-07-01

    Nodal diffusion methods still represent a standard in global reactor calculations, but employ some ad-hoc approximations (such as the quadratic leakage approximation) which limit their accuracy in cases where reference quality solutions are sought. In this work we solve the nodal diffusion equations utilizing the so-called higher-order nodal methods to generate reference quality solutions and to decompose the obtained solutions via a technique known as High Dimensional Model Representation (HDMR). This representation and associated decomposition of the solution provides a new formulation of the transverse leakage term. The HDMR structure is investigated via the technique of Analysis of Variance (ANOVA), which indicates why the existing class of transversely-integrated nodal methods prove to be so successful. Furthermore, the analysis leads to a potential solution method for generating reference quality solutions at a much reduced calculational cost, by applying the ANOVA technique to the full higher order solution. (authors)

  10. Simultaneous silence organizes structured higher-order interactions in neural populations

    PubMed Central

    Shimazaki, Hideaki; Sadeghi, Kolia; Ishikawa, Tomoe; Ikegaya, Yuji; Toyoizumi, Taro

    2015-01-01

    Activity patterns of neural population are constrained by underlying biological mechanisms. These patterns are characterized not only by individual activity rates and pairwise correlations but also by statistical dependencies among groups of neurons larger than two, known as higher-order interactions (HOIs). While HOIs are ubiquitous in neural activity, primary characteristics of HOIs remain unknown. Here, we report that simultaneous silence (SS) of neurons concisely summarizes neural HOIs. Spontaneously active neurons in cultured hippocampal slices express SS that is more frequent than predicted by their individual activity rates and pairwise correlations. The SS explains structured HOIs seen in the data, namely, alternating signs at successive interaction orders. Inhibitory neurons are necessary to maintain significant SS. The structured HOIs predicted by SS were observed in a simple neural population model characterized by spiking nonlinearity and correlated input. These results suggest that SS is a ubiquitous feature of HOIs that constrain neural activity patterns and can influence information processing. PMID:25919985

  11. Design and construction of higher-order structure and function in proteinosome-based protocells.

    PubMed

    Huang, Xin; Patil, Avinash J; Li, Mei; Mann, Stephen

    2014-06-25

    The design and construction of higher-order structure and function in proteinosome microcompartments enclosed by a cross-linked membrane of amphiphilic bovine serum albumin/poly(N-isopropylacrylamide) (BSA-NH2/PNIPAAm) nanoconjugates is described. Three structure/function relationships are investigated: (i) differential chemical cross-linking for the control of membrane disassembly and regulated release of encapsulated genetic polymers; (ii) enzyme-mediated hydrogel structuring of the internal microenvironment to increase mechanical robustness and generate a molecularly crowded reaction environment; and (iii) self-production of a membrane-enclosing outer hydrogel wall for generating protease-resistant forms of the protein-polymer protocells. Our results highlight the potential of integrating aspects of supramolecular and polymer chemistry into the design and construction of novel bioinspired microcompartments as a step toward small-scale materials systems based on synthetic cellularity. PMID:24905973

  12. Higher-order structure in the trajectories of depression and anxiety following sudden involuntary unemployment.

    PubMed

    Howe, George W; Hornberger, Anna P; Weihs, Karen; Moreno, Francisco; Neiderhiser, Jenae M

    2012-05-01

    Recent work on comorbidity finds evidence for hierarchical structure of mood and anxiety disorders and symptoms. This study tests whether a higher-order internalizing factor accounts for variation in depression and anxiety symptom severity and change over time in a sample experiencing a period of major life stress. Data on symptoms of depression, chronic worry, and social anxiety were collected five times across seven months from 426 individuals who had recently lost jobs. Growth models for each type of symptom found significant variation in individual trajectories. Slopes were highly correlated across symptom type, as were intercepts. Multilevel confirmatory factor analyses found evidence for a higher-order internalizing factor for both slopes and intercepts, reflective of comorbidity of depression and anxiety, with the internalizing factor accounting for 54% to 91% of the variance in slopes and intercepts of specific symptom sets, providing evidence for both a general common factor and domain-specific factors characterizing level and change in symptoms. Loadings on the higher order factors differed modestly for men and women, and when comparing African American and White participants, but did not differ by age, education, or history of depression. More distal factors including gender and history of depression were strongly associated with internalizing in the early weeks after job loss, but rates of change in internalizing were associated most strongly with reemployment. Findings suggest that stressors may contribute in different ways to the common internalizing factor as compared to variance in anxiety and depression that is independent of that factor. PMID:22103803

  13. SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells.

    PubMed

    Barutcu, A Rasim; Lajoie, Bryan R; Fritz, Andrew J; McCord, Rachel P; Nickerson, Jeffrey A; van Wijnen, Andre J; Lian, Jane B; Stein, Janet L; Dekker, Job; Stein, Gary S; Imbalzano, Anthony N

    2016-09-01

    The packaging of DNA into chromatin plays an important role in transcriptional regulation and nuclear processes. Brahma-related gene-1 SMARCA4 (also known as BRG1), the essential ATPase subunit of the mammalian SWI/SNF chromatin remodeling complex, uses the energy from ATP hydrolysis to disrupt nucleosomes at target regions. Although the transcriptional role of SMARCA4 at gene promoters is well-studied, less is known about its role in higher-order genome organization. SMARCA4 knockdown in human mammary epithelial MCF-10A cells resulted in 176 up-regulated genes, including many related to lipid and calcium metabolism, and 1292 down-regulated genes, some of which encode extracellular matrix (ECM) components that can exert mechanical forces and affect nuclear structure. ChIP-seq analysis of SMARCA4 localization and SMARCA4-bound super-enhancers demonstrated extensive binding at intergenic regions. Furthermore, Hi-C analysis showed extensive SMARCA4-mediated alterations in higher-order genome organization at multiple resolutions. First, SMARCA4 knockdown resulted in clustering of intra- and inter-subtelomeric regions, demonstrating a novel role for SMARCA4 in telomere organization. SMARCA4 binding was enriched at topologically associating domain (TAD) boundaries, and SMARCA4 knockdown resulted in weakening of TAD boundary strength. Taken together, these findings provide a dynamic view of SMARCA4-dependent changes in higher-order chromatin organization and gene expression, identifying SMARCA4 as a novel component of chromatin organization. PMID:27435934

  14. A family of higher-order integration methods for structural dynamics

    SciTech Connect

    Chang, S.Y.

    1996-12-01

    A new family of higher-order implicit, one-step integration algorithms has been developed by Chang (1994). These algorithms have minimum order of accuracy two, and maximum order of accuracy four. In general, they have order of accuracy three. All the algorithms are unconditionally stable, do not overshoot in displacements or in velocities and possess desirable numerical dissipation which can be continuously controlled. In particular, these schemes possess better dissipative and dispersive characteristics than the commonly used second-order methods. It has been found that one of these algorithms can provide an appropriate amplitude compensation effect for nonlinear systems. This amplitude compensation effect can effectively suppress the linearization errors which are introduced by the assumption that the structural properties remain constant during each time step. Because of the excellent properties possessed by the algorithm, especially the amplitude compensation effect and no growth of high-frequency response, a time step as large as two orders of magnitude greater than what is needed for the average acceleration method can be used, leading to a very significant saving of computational effort.

  15. Higher-Order Structure of the Rous Sarcoma Virus SP Assembly Domain

    PubMed Central

    Bush, Di L.; Monroe, Eric B.; Bedwell, Gregory J.; Phillips, Judith M.

    2014-01-01

    ABSTRACT Purified retroviral Gag proteins can assemble in vitro to form immature virus-like particles (VLPs). By cryoelectron tomography, Rous sarcoma virus VLPs show an organized hexameric lattice consisting chiefly of the capsid (CA) domain, with periodic stalk-like densities below the lattice. We hypothesize that the structure represented by these densities is formed by amino acid residues immediately downstream of the folded CA, namely, the short spacer peptide SP, along with a dozen flanking residues. These 24 residues comprise the SP assembly (SPA) domain, and we propose that neighboring SPA units in a Gag hexamer coalesce to form a six-helix bundle. Using in vitro assembly, alanine scanning mutagenesis, and biophysical analyses, we have further characterized the structure and function of SPA. Most of the amino acid residues in SPA could not be mutated individually without abrogating assembly, with the exception of a few residues near the N and C termini, as well as three hydrophilic residues within SPA. We interpret these results to mean that the amino acids that do not tolerate mutations contribute to higher-order structures in VLPs. Hydrogen-deuterium exchange analyses of unassembled Gag compared that of assembled VLPs showed strong protection at the SPA region, consistent with a higher-order structure. Circular dichroism revealed that a 29mer SPA peptide shifts from a random coil to a helix in a concentration-dependent manner. Analytical ultracentrifugation showed concentration-dependent self-association of the peptide into a hexamer. Taken together, these results provide strong evidence for the formation of a critical six-helix bundle in Gag assembly. IMPORTANCE The structure of a retrovirus like HIV is created by several thousand molecules of the viral Gag protein, which assemble to form the known hexagonal protein lattice in the virus particle. How the Gag proteins pack together in the lattice is incompletely understood. A short segment of Gag known to

  16. Variational-method-based higher order mode analysis extendible to realistic tapered disk-loaded structures

    NASA Astrophysics Data System (ADS)

    Wang, L. F.; Lin, Y. Z.; Higo, T.

    2002-04-01

    In order to obtain high luminosity and energy efficiency in future linear colliders, most designs for e + and e - collisions in the TeV range will use multi-bunch operation. Therefore, the study of higher order modes excited by previous bunches in the train becomes very important for the optimal design of the accelerator components. Many designs have used tapered disk-loaded waveguides for acceleration. Various numerical methods have been used for the modal analysis of the structure. In this paper, a high-precision eigenmode-computation analysis based on a variational method will be discussed. It allows for rounding the edge of a disk hole without any approximation in shape treatment and calculates the exactly synchronous modes. It converges much faster than the mesh-based computer code SUPERFISH. Good agreement was observed between the results of the variational method and those of other methods.

  17. Representation of higher-order statistical structures in natural scenes via spatial phase distributions.

    PubMed

    MaBouDi, HaDi; Shimazaki, Hideaki; Amari, Shun-Ichi; Soltanian-Zadeh, Hamid

    2016-03-01

    Natural scenes contain richer perceptual information in their spatial phase structure than their amplitudes. Modeling phase structure of natural scenes may explain higher-order structure inherent to the natural scenes, which is neglected in most classical models of redundancy reduction. Only recently, a few models have represented images using a complex form of receptive fields (RFs) and analyze their complex responses in terms of amplitude and phase. However, these complex representation models often tacitly assume a uniform phase distribution without empirical support. The structure of spatial phase distributions of natural scenes in the form of relative contributions of paired responses of RFs in quadrature has not been explored statistically until now. Here, we investigate the spatial phase structure of natural scenes using complex forms of various Gabor-like RFs. To analyze distributions of the spatial phase responses, we constructed a mixture model that accounts for multi-modal circular distributions, and the EM algorithm for estimation of the model parameters. Based on the likelihood, we report presence of both uniform and structured bimodal phase distributions in natural scenes. The latter bimodal distributions were symmetric with two peaks separated by about 180°. Thus, the redundancy in the natural scenes can be further removed by using the bimodal phase distributions obtained from these RFs in the complex representation models. These results predict that both phase invariant and phase sensitive complex cells are required to represent the regularities of natural scenes in visual systems. PMID:26278166

  18. Protein-protein interactions in a higher-order structure direct lambda site-specific recombination.

    PubMed

    Thompson, J F; de Vargas, L M; Skinner, S E; Landy, A

    1987-06-01

    The highly directional site-specific recombination of bacteriophage lambda is tightly regulated by the binding of three different proteins to a complex array of sites. The manner in which these reactions are both stimulated and inhibited by co-operative binding of proteins to specific sites on the P arm of attP and AttR has been elucidated by correlation of nuclease protection with recombination studies of both wild-type and mutant DNAs. In addition to co-operative forces, there is a specific competitive interaction that allows the protein-DNA complex to serve as a "biological switch". This switch does not depend upon the simple occlusion of DNA binding sites by neighboring proteins; but, rather, the outcome of this competition is dependent on long-range interactions that vary between the higher-order structures of attP and attR. These higher-order structures are dependent on cooperative interactions involving three proteins binding to five or more sites. PMID:2958633

  19. An evaluation of higher-order model methods for calculating transient structural response

    NASA Technical Reports Server (NTRS)

    Camarda, Charles J.; Haftka, Raphael T.; Riley, Michael F.

    1987-01-01

    A higher-order modal method proposed by Leung for transient structural analysis entitled the force-derivative method is evaluated. This method repeatedly integrates by parts with respect to time the convolution-integral form of the structural response to produce successively better approximations to the contribution of the higher modes which are neglected in the modal summation. Comparisons are made of the force-derivative, the mode-displacement, and the mode-acceleration methods for several numerical example problems for various times, levels of damping, and forcing functions. The example problems include a tip-loaded cantilevered beam and a simply-supported multispan beam. The force-derivative method is shown to converge to an accurate solution in fewer modes than either the mode-displacement or the mode-acceleration methods. In addition, for problems in which there are a large number of closely-spaced frequencies whose mode shapes have a negligible contribution to the response, the force-derivative method is very effective in representing the effect of the important, but otherwise neglected, higher modes.

  20. Structural damage detection using higher-order finite elements and a scanning laser vibrometer

    NASA Astrophysics Data System (ADS)

    Jin, Si

    In contrast to conventional non-destructive evaluation methods, dynamics-based damage detection methods are capable of rapid integrity evaluation of large structures and have received considerable attention from aerospace, mechanical, and civil engineering communities in recent years. However, the identifiable damage size using dynamics-based methods is determined by the number of sensors used, level of measurement noise, accuracy of structural models, and signal processing techniques. In this thesis we study dynamics of structures with damage and then derive and experimentally verify new model-independent structural damage detection methods that can locate small damage to structures. To find sensitive damage detection parameters we develop a higher-order beam element that enforces the continuity of displacements, slopes, bending moments, and shear forces at all nodes, and a higher-order rectangular plate element that enforces the continuity of displacements, slopes, and bending and twisting moments at all nodes. These two elements are used to study the dynamics of beams and plates. Results show that high-order spatial derivatives of high-frequency modes are important sensitive parameters that can locate small structural damage. Unfortunately the most powerful and popular structural modeling technique, the finite element method, is not accurate in predicting high-frequency responses. Hence, a model-independent method using dynamic responses obtained from high density measurements is concluded to be the best approach. To increase measurement density and reduce noise a Polytec PI PSV-200 scanning laser vibrometer is used to provide non-contact, dense, and accurate measurements of structural vibration velocities. To avoid the use of structural models and to extract sensitive detection parameters from experimental data, a brand-new structural damage detection method named BED (Boundary-Effect Detection) is developed for pinpointing damage locations using Operational

  1. Higher Order Amyloid Fibril Structure by MAS NMR and DNP Spectroscopy

    PubMed Central

    Debelouchina, Galia T.; Bayro, Marvin J.; Fitzpatrick, Anthony W.; Ladizhansky, Vladimir; Colvin, Michael T.; Caporini, Marc A.; Jaroniec, Christopher P.; Bajaj, Vikram S.; Rosay, Melanie; MacPhee, Cait E.; Vendruscolo, Michele; Maas, Werner E.; Dobson, Christopher M.; Griffin, Robert G.

    2014-01-01

    Protein magic angle spinning (MAS) NMR spectroscopy has generated structural models of several amyloid fibril systems, thus providing valuable information regarding the forces and interactions that confer the extraordinary stability of the amyloid architecture. Despite these advances, however, obtaining atomic resolution information describing the higher levels of structural organization within the fibrils remains a significant challenge. Here, we detail MAS NMR experiments and sample labeling schemes designed specifically to probe such higher order amyloid structure and we have applied them to the fibrils formed by an eleven-residue segment of the amyloidogenic protein transthyretin (TTR(105-115)). These experiments have allowed us to define unambiguously not only the arrangement of the peptide β-strands into β-sheets but also the β-sheet interfaces within each protofilament, and in addition to identify the nature of the protofilament-to-protofilament contacts that lead to the formation of the complete fibril. Our efforts have resulted in 111 quantitative distance and torsion angle restraints (10 per residue) that describe the various levels of structure organization. The experiments benefited extensively from the use of dynamic nuclear polarization (DNP), which in some cases allowed us to shorten the data acquisition time from days to hours and to improve significantly the signal-to-noise ratios of the spectra. The β-sheet interface and protofilament interactions identified here revealed local variations in the structure that result in multiple peaks for the exposed N- and C-termini of the peptide and in inhomogeneous line-broadening for the side-chains buried within the interior of the fibrils. PMID:24304221

  2. Aromatic Interactions Promote Self-association of Collagen Triple-helical Peptides to Higher Order Structures

    PubMed Central

    Kar, Karunakar; Ibrar, Sajjad; Nanda, Vikas; Getz, Todd M.; Kunapuli, Satya P.; Brodsky, Barbara

    2009-01-01

    Aromatic residues are relatively rare within the collagen triple-helix, but they appear to play a specialized role in higher order structure and function. The role of aromatic amino acids in the self-assembly of triple-helical peptides was investigated in terms of the kinetics of self-association, the nature of aggregated species formed, and the ability of these species to activate platelet aggregation. The presence of aromatic residues on both ends of a type IV collagen model peptide is observed to greatly accelerate the kinetics of self-association, decreasing the lag time and leading to insoluble, well defined linear fibrils as well as small soluble aggregates. Both macroscopic visible aggregates and small multi-molecular complexes in solution are capable of inducing platelet aggregation through the glycoprotein VI receptor on platelets. Proline-aromatic CH⋯π interactions are often observed within globular proteins and in protein complexes, and examination of molecular packing in the crystal structure of the integrin binding collagen peptide shows Phe interacts with Pro/Hyp in a neighboring triple-helical molecule. An intermolecular interaction between aromatic amino acids and imino acids within the triple-helix is also supported by the observed inhibitory effect of isolated Phe amino acids on the self-association of (Pro-Hyp-Gly)10. Given the high fraction of Pro and Hyp residues on the surface of collagen molecules, it is likely that imino acid-aromatic CH⋯π interactions are important in formation of higher order structure. It is suggested that the catalysis of type I collagen fibrillogenesis by non-helical telopeptides is due to specific intermolecular CH⋯π interactions between aromatic residues in the telopeptides and Pro/Hyp residues within the triple-helix. PMID:19610672

  3. Electron transfer dissociation provides higher-order structural information of native and partially unfolded protein complexes.

    PubMed

    Lermyte, Frederik; Sobott, Frank

    2015-08-01

    Top-down sequencing approaches are becoming ever more popular for protein characterization, due to the ability to distinguish and characterize different protein isoforms. Under non-denaturing conditions, electron transfer dissociation (ETD) can furthermore provide important information on the exposed surface of proteins or complexes, thereby contributing to the characterization of their higher-order structure. Here, we investigate this approach using top-down ETD of tetrameric hemoglobin, concanavalin A, and alcohol dehydrogenase combined with ion mobility (IM) on a commercially available quadrupole/ion mobility/time-of-flight instrument (Waters Synapt G2). By applying supplemental activation in the transfer cell (post-IM), we release ETD fragments and attain good sequence coverage in the exposed terminal regions of the protein. We investigate the correlation between observed sites of fragmentation with regions of solvent accessibility, as derived from the crystal structure. Ion acceleration prior to ETD is also used to cause collision-induced unfolding (CIU) of the complexes without monomer ejection, as evidenced by the IM profiles. These partially unfolded tetramers show efficient fragmentation in some regions which are not sequenced under more gentle MS conditions. We show that by increasing CIU in small increments and monitoring the changes in the fragmentation pattern, it is possible to follow the initial steps of gas-phase protein unfolding. Fragments from partially unfolded protein complexes are released immediately after electron transfer, prior to IM (they do not share the drift time of their precursor), and observed without the need for supplemental activation. This is further evidence that the higher-order structure in these protein regions has been disrupted. PMID:26081219

  4. Thermo-Elastic Analysis of Internally Cooled Structures Using a Higher Order Theory

    NASA Technical Reports Server (NTRS)

    Arnold, Steven M.; Bednarcyk, Brett A.; Aboudi, Jacob

    2001-01-01

    This paper presents the results of a study on the thermomechanical behavior of internally cooled silicon nitride structures. Silicon nitride is under consideration for elevated temperature aerospace engine applications. and techniques for lowering the operating temperature of structures composed of this material are under development. Lowering the operating temperature provides a large payoff in terms of fatigue life and may be accomplished through the use of thermal barrier coatings (TBC's) and the novel concept of included cooling channels. Herein, an in-depth study is performed on the behavior of a flame-impinged silicon nitride plate with a TBC and internal channels cooled by forced air. The analysis is performed using the higher order theory for functionally graded materials (HOTFGM), which has been developed through NASA Glenn Research Center funding over the past several years. HOTFGM was chosen over the traditional finite element approach as a prelude to an examination of functionally graded silicon nitride structures for which HOTFGM is ideally suited. To accommodate the analysis requirement% of the internally cooled plate problem, two crucial enhancements were made to the two-dimensional Cartesian-based version of HOTFGM. namely, incorporation of internal boundary capabilities and incorporation of convective boundary conditions. Results indicate the viability and large benefits of cooling the plate via forced air through cooling channels. Furthermore, cooling can positively impact the stress and displacement fields present in the plate, yielding an additional payoff in terms of fatigue life. Finally, a spin-off capability resulted from inclusion of internal boundaries within HOTFGM; the ability to simulate the thermo-elastic response of structures with curved surfaces. This new capability is demonstrated, and through comparison with an analytical solution, shown to be viable and accurate.

  5. RF-Thermal-Structural Analysis of a Waveguide Higher Order Mode Absorber

    SciTech Connect

    G. Cheng; E. F. Daly; R. A. Rimmer; M. Stirbet; L. Vogel; H. Wang; K. M. Wilson

    2007-07-03

    For an ongoing high current cryomodule project, a total of 5 higher order mode (HOM) absorbers are required per cavity. The load is designed to absorb Radio Frequency (RF) heat induced by HOMs in a 748.5MHz cavity. Each load is targeted at a 4 kW dissipation capability. Water cooling is employed to remove the heat generated in ceramic tiles and by surface losses on the waveguide walls. A sequentially coupled RF-thermal-structural analysis was developed in ANSYS to optimize the HOM load design. Frequency-dependent dielectric material properties measured from samples and RF power spectrum calculated by the beam-cavity interaction codes were considered. The coupled field analysis capability of ANSYS avoided mapping of results between separate RF and thermal/structural simulation codes. For verification purposes, RF results obtained from ANSYS were compared to those from MAFIA, HFSS, and Microwave Studio. Good agreement was reached and this confirms that multiple-field coupled analysis is a desirable choice in analysis of HOM loads. Similar analysis could be performed on other particle accelerator components where distributed RF heating and surface current induced losses are inevitable.

  6. Continued Stabilization of the Nuclear Higher-Order Structure of Post-Mitotic Neurons In Vivo

    PubMed Central

    Alva-Medina, Janeth; Maya-Mendoza, Apolinar; Dent, Myrna A. R.; Aranda-Anzaldo, Armando

    2011-01-01

    Background Cellular terminal differentiation (TD) correlates with a permanent exit from the cell cycle and so TD cells become stably post-mitotic. However, TD cells express the molecular machinery necessary for cell proliferation that can be reactivated by experimental manipulation, yet it has not been reported the stable proliferation of any type of reactivated TD cells. Neurons become post-mitotic after leaving the ventricular zone. When neurons are forced to reenter the cell cycle they invariably undergo cell death. Wider evidence indicates that the post-mitotic state cannot solely depend on gene products acting in trans, otherwise mutations in the corresponding genes may lead to reentry and completion of the cell cycle in TD cells, but this has not been observed. In the interphase, nuclear DNA of metazoan cells is organized in supercoiled loops anchored to a nuclear nuclear matrix (NM). The DNA-NM interactions define a higher-order structure in the cell nucleus (NHOS). We have previously compared the NHOS of aged rat hepatocytes with that of early post-mitotic rat neurons and our results indicated that a very stable NHOS is a common feature of both senescent and post-mitotic cells in vivo. Principal Findings In the present work we compared the NHOS in rat neurons from different post-natal ages. Our results show that the trend towards further stabilization of the NHOS in neurons continues throughout post-natal life. This phenomenon occurs in absence of overt changes in the post-mitotic state and transcriptional activity of neurons, suggesting that it is independent of functional constraints. Conclusions Apparently the continued stabilization of the NHOS as a function of time is basically determined by thermodynamic and structural constraints. We discuss how the resulting highly stable NHOS of neurons may be the structural, non-genetic basis of their permanent and irreversible post-mitotic state. PMID:21731716

  7. Development of antibody arrays for monoclonal antibody Higher Order Structure analysis

    PubMed Central

    Wang, Xing; Li, Qing; Davies, Michael

    2013-01-01

    Antibody arrays were developed to probe a monoclonal antibody's three-dimensional structure (3-D structure). Peptides with overlapping regions were designed to cover the whole mAb light chain and heavy chain, respectively, and used to generate polyclonal antibodies after the conjugation of the peptides to a carrier protein, KLH. It was shown that good peptide specificity was achieved from the antibodies generated. Using more than 30 different polyclonal antibodies to measure the surface epitope distribution, it was shown that the mAb antibody array can detect epitope exposure as low as 0.1% of defined mAb populations. This ELISA-based analysis of mAb epitope exposure can be considered as a measurement of “conformational impurity” in biologics development, similar to the analysis of other product-related impurities such as different forms of glycosylation, deamidation, and oxidation. This analysis of “conformational impurity” could provide valuable information on the mAb conformational comparability for biosimilar mAbs as well as novel mAbs, especially in the area of protein immunogenicity. Furthermore, stability studies indicated that there are several conformational “hot spots” in many mAbs tested, especially in the hinge region. This antibody array technology can be used for novel mAb Higher Order Structure (HOS) analysis during process and formulation development. Another important area of application is for biosimilar mAb development where the innovator molecule and biosimilar molecule could be compared based on their systemic “fingerprint” from the 30 plus antibodies. PMID:23970865

  8. Higher-Order Theory: Structural/MicroAnalysis Code (HOTSMAC) Developed

    NASA Technical Reports Server (NTRS)

    Arnold, Steven M.

    2002-01-01

    The full utilization of advanced materials (be they composite or functionally graded materials) in lightweight aerospace components requires the availability of accurate analysis, design, and life-prediction tools that enable the assessment of component and material performance and reliability. Recently, a new commercially available software product called HOTSMAC (Higher-Order Theory--Structural/MicroAnalysis Code) was jointly developed by Collier Research Corporation, Engineered Materials Concepts LLC, and the NASA Glenn Research Center under funding provided by Glenn's Commercial Technology Office. The analytical framework for HOTSMAC is based on almost a decade of research into the coupled micromacrostructural analysis of heterogeneous materials. Consequently, HOTSMAC offers a comprehensive approach for analyzing/designing the response of components with various microstructural details, including certain advantages not always available in standard displacement-based finite element analysis techniques. The capabilities of HOTSMAC include combined thermal and mechanical analysis, time-independent and time-dependent material behavior, and internal boundary cells (e.g., those that can be used to represent internal cooling passages, see the preceding figure) to name a few. In HOTSMAC problems, materials can be randomly distributed and/or functionally graded (as shown in the figure, wherein the inclusions are distributed linearly), or broken down by strata, such as in the case of thermal barrier coatings or composite laminates.

  9. Solvent-Dependent Properties and Higher-Order Structures of Aryl Alcohol + Surfactant Molecular Gels.

    PubMed

    Katsube, Shotaro; Kinoshita, Masaru; Amano, Kenshi; Sato, Takaaki; Katsumoto, Yukiteru; Umecky, Tatsuya; Takamuku, Toshiyuki; Kaji, Toshihiko; Hiramoto, Masahiro; Tsurunaga, Yoko; Nishiyama, Katsura

    2016-05-01

    Molecular organogels, comprising small organic gelators in solvents, can be applied for dispersal of optical devices, such as emitters. Phenolic compounds and the surfactant bis(2-ethylhexyl) sulfosuccinate (AOT) are known examples of self-assembly organogels. However, conventional phenol + AOT gels in aromatic and acyclic alkane solvents are optically turbid, which is an obstacle for use as host materials in optical devices. In this study, a variety of aryl alcohol-AOT-solvent sets have been investigated systematically, and the correlation between the molecular architecture and optical transparency of the gels was considered. Accordingly, p-chlorophenol + AOT gels in cyclic alkane solvents were shown to form optically transparent gels. In contrast, aromatic and acyclic alkane solvents gave rise to turbid or opaque gels, even when utilizing the same gelators. AFM, NMR, SAXS, and FTIR were employed to determine the organogel structures. Consequently, we found that the gel transparency strongly depends on the size of the fibrous network of the gel, the structure of which is attributed to higher-order aggregates of the gelators. The average contour length and diameter of the fibrous network, lav and dav, respectively, were determined from AFM images. The transparent gels were shown to have lav = 4-9 μm and dav ≤ 0.3 μm, whereas the turbid gels had lav = 15 μm and dav = 0.4-0.6 μm. Such differences in the size of the fibrous network significantly affected the mechanical response of the gels, as shown by stress-strain measurements. PMID:27064848

  10. An Examination of the Higher-Order Structure of Psychopathology and Its Relationship to Personality.

    PubMed

    Uliaszek, Amanda A; Zinbarg, Richard E

    2016-04-01

    This study compared a series of higher-order models encompassing symptoms of both clinical and personality disorders. The final model was then correlated with a latent variable model of normal personality traits. A total of 420 undergraduates completed a battery of self-report symptom and personality questionnaires, with informant-reports and diagnostic interviews provided by overlapping subsamples. A three-level model with two factors at the highest level and four factors at the second level was the best fitting model. The higher-order internalizing and externalizing factors were then correlated with 30 latent personality facets. Results demonstrate an elevation on the neuroticism facets for the higher-order internalizing factor, along with low positive emotions, low actions, and low competence. The higher-order externalizing factor was negatively associated with most conscientiousness and agreeableness factors, while showing an elevation on excitement-seeking, impulsivity, and angry hostility. Future studies should replicate these models with the inclusion of more low base-rate disorders (i.e., psychosis). PMID:25893555

  11. The higher-order structure in the cells nucleus as the structural basis of the post-mitotic state.

    PubMed

    Aranda-Anzaldo, Armando; Dent, Myrna A R; Martínez-Gómez, Alejandro

    2014-05-01

    In metazoan cells during the interphase nuclear DNA is organized in supercoiled, topologically constrained loops anchored to a proteinaceous compartment or substructure commonly known as the nuclear matrix (NM). The DNA-NM interactions result from a thermodynamically-driven process leading to the necessary dissipation of structural stress along chromosomal DNA, otherwise the chromosomes would break into pieces. Such DNA-NM interactions define a nuclear higher-order structure that is independent of chromatin proteins. On the other hand, a metazoan cell no longer able to undergo mitosis is defined as post-mitotic and this condition indicates a terminally differentiated cell that may survive in such a state for indefinite time. The non-reversible nature of the post-mitotic state suggests a non-genetic basis for it since no spontaneous or induced mutations can revert it. Yet in individual cells the loss of proliferative potential has both a developmental and a stochastic component. Here we discuss evidence suggesting that the stability of the nuclear higher-order structure is the factor that links the stochastic and developmental components leading to the post-mitotic state. PMID:24556025

  12. Higher-order aggregate networks in the analysis of temporal networks: path structures and centralities

    NASA Astrophysics Data System (ADS)

    Scholtes, Ingo; Wider, Nicolas; Garas, Antonios

    2016-03-01

    Despite recent advances in the study of temporal networks, the analysis of time-stamped network data is still a fundamental challenge. In particular, recent studies have shown that correlations in the ordering of links crucially alter causal topologies of temporal networks, thus invalidating analyses based on static, time-aggregated representations of time-stamped data. These findings not only highlight an important dimension of complexity in temporal networks, but also call for new network-analytic methods suitable to analyze complex systems with time-varying topologies. Addressing this open challenge, here we introduce a novel framework for the study of path-based centralities in temporal networks. Studying betweenness, closeness and reach centrality, we first show than an application of these measures to time-aggregated, static representations of temporal networks yields misleading results about the actual importance of nodes. To overcome this problem, we define path-based centralities in higher-order aggregate networks, a recently proposed generalization of the commonly used static representation of time-stamped data. Using data on six empirical temporal networks, we show that the resulting higher-order measures better capture the true, temporal centralities of nodes. Our results demonstrate that higher-order aggregate networks constitute a powerful abstraction, with broad perspectives for the design of new, computationally efficient data mining techniques for time-stamped relational data.

  13. Maintenance of a functional higher order chromatin structure: The role of the nuclear matrix in normal and disease states

    PubMed Central

    Linnemann, Amelia K.; Krawetz, Stephen A.

    2010-01-01

    Summary The ordered packaging of DNA within the nucleus of somatic cells reflects a dynamic supportive structure that facilitates stable transcription interrupted by intermittent cycles of extreme condensation. This dynamic mode of packing and unpacking chromatin is intimately linked to the ability of the genome to specifically complex with both histones and non-histone proteins. Understanding the underlying mechanism that governs the formation of higher order chromatin structures is a key to understanding how local architecture modulates transcription. In part, the formation of these structures appears to be regulated through genomic looping that is dynamically mediated by attachment to the nuclear scaffold/matrix at S/MARs, i.e., Scaffold/Matrix Attachment Regions. Although the mechanism guiding the formation and use of these higher-ordered structures remains unknown, S/MARs continue to reveal a multitude of roles in development and the pathogenesis of disease. PMID:20948980

  14. A generative spike train model with time-structured higher order correlations

    PubMed Central

    Trousdale, James; Hu, Yu; Shea-Brown, Eric; Josić, Krešimir

    2013-01-01

    Emerging technologies are revealing the spiking activity in ever larger neural ensembles. Frequently, this spiking is far from independent, with correlations in the spike times of different cells. Understanding how such correlations impact the dynamics and function of neural ensembles remains an important open problem. Here we describe a new, generative model for correlated spike trains that can exhibit many of the features observed in data. Extending prior work in mathematical finance, this generalized thinning and shift (GTaS) model creates marginally Poisson spike trains with diverse temporal correlation structures. We give several examples which highlight the model's flexibility and utility. For instance, we use it to examine how a neural network responds to highly structured patterns of inputs. We then show that the GTaS model is analytically tractable, and derive cumulant densities of all orders in terms of model parameters. The GTaS framework can therefore be an important tool in the experimental and theoretical exploration of neural dynamics. PMID:23908626

  15. Higher Order Factor Structure of a Self-Control Test: Evidence from Confirmatory Factor Analysis with Polychoric Correlations.

    ERIC Educational Resources Information Center

    Flora, David B.; Finkel, Eli J.; Foshee, Vangie A.

    2003-01-01

    Studied the higher order factor structure of a self-control test developed by H. Grasmick and others (1993). Results for 1,966 eighth and ninth graders show that the self-control test may provide more valid measurement of the constructs it was designed to measure than previous research suggested. (SLD)

  16. The Effect of a Structured Story Reading Intervention, Story Retelling and Higher Order Thinking for English Language and Literacy Acquisition

    ERIC Educational Resources Information Center

    Cruz de Quiros, Ana M.; Lara-Alecio, Rafael; Tong, Fuhui; Irby, Beverly J.

    2012-01-01

    The purpose of this study was to investigate the effectiveness of structured story reading intervention, "S"tory re"T"elling and higher order thinking for "E"nglish "L"anguage and "L"iteracy "A"cquisition (STELLA), delivered to 38 Hispanic English language learners (ELL) placed in an enhanced transitional bilingual programme over 2 years from…

  17. Orthogonal Higher Order Factor Structure of the Stanford-Binet Intelligence Scales--Fifth Edition for Children and Adolescents

    ERIC Educational Resources Information Center

    Canivez, Gary L.

    2008-01-01

    Orthogonal higher-order factor structure of the Stanford-Binet Intelligence Scales-Fifth Edition (SB-5; Roid, 2003a) for child and adolescent samples is reported. Multiple criteria for factor extraction unanimously supported extraction of only one dimension and a unidimensional model. However, following results from DiStefano and Dombrowski (2006)…

  18. A symmetric modal formulation of fluid-structure interaction, including a static approximation to higher order fluid modes

    NASA Technical Reports Server (NTRS)

    Macneal, R. H.; Citerley, R.; Chargin, M.

    1980-01-01

    A method of fluid-structure coupling which provides symmetrical matrix equations of standard form solved by existing finite element computer programs is presented. The method postulates that the uncoupled vibration modes of the fluid or the structure be calculated before the coupled analysis. A numerical solution of vibration modes in an axisymmetric container demonstrated that a static approximation to higher order fluid modes can improve the accuracy of dynamic response computations using modal methods.

  19. Understanding the Functions of Long Non-Coding RNAs through Their Higher-Order Structures.

    PubMed

    Li, Rui; Zhu, Hongliang; Luo, Yunbo

    2016-01-01

    Although thousands of long non-coding RNAs (lncRNAs) have been discovered in eukaryotes, very few molecular mechanisms have been characterized due to an insufficient understanding of lncRNA structure. Therefore, investigations of lncRNA structure and subsequent elucidation of the regulatory mechanisms are urgently needed. However, since lncRNA are high molecular weight molecules, which makes their crystallization difficult, obtaining information about their structure is extremely challenging, and the structures of only several lncRNAs have been determined so far. Here, we review the structure-function relationships of the widely studied lncRNAs found in the animal and plant kingdoms, focusing on the principles and applications of both in vitro and in vivo technologies for the study of RNA structures, including dimethyl sulfate-sequencing (DMS-seq), selective 2'-hydroxyl acylation analyzed by primer extension-sequencing (SHAPE-seq), parallel analysis of RNA structure (PARS), and fragmentation sequencing (FragSeq). The aim of this review is to provide a better understanding of lncRNA biological functions by studying them at the structural level. PMID:27196897

  20. Understanding the Functions of Long Non-Coding RNAs through Their Higher-Order Structures

    PubMed Central

    Li, Rui; Zhu, Hongliang; Luo, Yunbo

    2016-01-01

    Although thousands of long non-coding RNAs (lncRNAs) have been discovered in eukaryotes, very few molecular mechanisms have been characterized due to an insufficient understanding of lncRNA structure. Therefore, investigations of lncRNA structure and subsequent elucidation of the regulatory mechanisms are urgently needed. However, since lncRNA are high molecular weight molecules, which makes their crystallization difficult, obtaining information about their structure is extremely challenging, and the structures of only several lncRNAs have been determined so far. Here, we review the structure–function relationships of the widely studied lncRNAs found in the animal and plant kingdoms, focusing on the principles and applications of both in vitro and in vivo technologies for the study of RNA structures, including dimethyl sulfate-sequencing (DMS-seq), selective 2′-hydroxyl acylation analyzed by primer extension-sequencing (SHAPE-seq), parallel analysis of RNA structure (PARS), and fragmentation sequencing (FragSeq). The aim of this review is to provide a better understanding of lncRNA biological functions by studying them at the structural level. PMID:27196897

  1. Vibration suppression of laminated shell structures investigated using higher order shear deformation theory

    NASA Astrophysics Data System (ADS)

    Lee, S. J.; Reddy, J. N.

    2004-10-01

    Third-order shear deformation theories of laminated composite shells are developed using the strain-displacement relations of Donnell and Sanders theories. These theories also account for geometric nonlinearity in the von Kármán sense. Analytical (Navier) solutions for vibration suppression in cross-ply laminated composite shells with surface mounted smart material layers are developed using the linear versions of the two shell theories and for simply supported boundary conditions. Numerical results are presented to bring out the parametric effects of shell types (cylindrical, spherical, and doubly curved shells) and material properties on vibration suppression. A simple negative velocity feedback control in a closed loop is used.

  2. Higher-order proton structure corrections to the Lamb shift in muonic hydrogen

    SciTech Connect

    Carlson, Carl E.; Vanderhaeghen, Marc

    2011-08-15

    The recent conundrum with the proton charge radius inspires reconsideration of the corrections that enter into determinations of the proton size. We study the two-photon proton-structure corrections, with special consideration of the nonpole subtraction term in the dispersion relation and using fits to modern data to evaluate the energy contributions. We find that individual contributions change more than the total and present results with error estimates.

  3. Higher order stationary subspace analysis

    NASA Astrophysics Data System (ADS)

    Panknin, Danny; von Bünau, Paul; Kawanabe, Motoaki; Meinecke, Frank C.; Müller, Klaus-Robert

    2016-03-01

    Non-stationarity in data is an ubiquitous problem in signal processing. The recent stationary subspace analysis procedure (SSA) has enabled to decompose such data into a stationary subspace and a non-stationary part respectively. Algorithmically only weak non- stationarities could be tackled by SSA. The present paper takes the conceptual step generalizing from the use of first and second moments as in SSA to higher order moments, thus defining the proposed higher order stationary subspace analysis procedure (HOSSA). The paper derives the novel procedure and shows simulations. An obvious trade-off between the necessity of estimating higher moments and the accuracy and robustness with which they can be estimated is observed. In an ideal setting of plenty of data where higher moment information is dominating our novel approach can win against standard SSA. However, with limited data, even though higher moments actually dominate the underlying data, still SSA may arrive on par.

  4. Orthogonal higher order structure and confirmatory factor analysis of the French Wechsler Adult Intelligence Scale (WAIS-III).

    PubMed

    Golay, Philippe; Lecerf, Thierry

    2011-03-01

    According to the most widely accepted Cattell-Horn-Carroll (CHC) model of intelligence measurement, each subtest score of the Wechsler Intelligence Scale for Adults (3rd ed.; WAIS-III) should reflect both 1st- and 2nd-order factors (i.e., 4 or 5 broad abilities and 1 general factor). To disentangle the contribution of each factor, we applied a Schmid-Leiman orthogonalization transformation (SLT) to the standardization data published in the French technical manual for the WAIS-III. Results showed that the general factor accounted for 63% of the common variance and that the specific contributions of the 1st-order factors were weak (4.7%-15.9%). We also addressed this issue by using confirmatory factor analysis. Results indicated that the bifactor model (with 1st-order group and general factors) better fit the data than did the traditional higher order structure. Models based on the CHC framework were also tested. Results indicated that a higher order CHC model showed a better fit than did the classical 4-factor model; however, the WAIS bifactor structure was the most adequate. We recommend that users do not discount the Full Scale IQ when interpreting the index scores of the WAIS-III because the general factor accounts for the bulk of the common variance in the French WAIS-III. The 4 index scores cannot be considered to reflect only broad ability because they include a strong contribution of the general factor. PMID:21171782

  5. Functional requirements of AID's higher order structures and their interaction with RNA-binding proteins.

    PubMed

    Mondal, Samiran; Begum, Nasim A; Hu, Wenjun; Honjo, Tasuku

    2016-03-15

    Activation-induced cytidine deaminase (AID) is essential for the somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes. Although both the N and C termini of AID have unique functions in DNA cleavage and recombination, respectively, during SHM and CSR, their molecular mechanisms are poorly understood. Using a bimolecular fluorescence complementation (BiFC) assay combined with glycerol gradient fractionation, we revealed that the AID C terminus is required for a stable dimer formation. Furthermore, AID monomers and dimers form complexes with distinct heterogeneous nuclear ribonucleoproteins (hnRNPs). AID monomers associate with DNA cleavage cofactor hnRNP K whereas AID dimers associate with recombination cofactors hnRNP L, hnRNP U, and Serpine mRNA-binding protein 1. All of these AID/ribonucleoprotein associations are RNA-dependent. We propose that AID's structure-specific cofactor complex formations differentially contribute to its DNA-cleavage and recombination functions. PMID:26929374

  6. Higher-order structure of nucleic acids in the gas phase: top-down analysis of base-pairing interactions

    PubMed Central

    Fabris, D.; Kellersberger, K.A.; Wilhide, J.A.

    2012-01-01

    Non-ergodic as well as ergodic activation methods are capable of maintaining the integrity of base pairs during the top-down analysis of nucleic acids. Here, we investigate the significance of this characteristic in the investigation of higher-order structures of increasing complexity. We show that cognate fragments produced by typical backbone cleavages may not be always detected as separate sequence ions, but rather as individual products that remain associated through mutual pairing contacts. This effect translates into unintended masking of cleavage events that take place in double-stranded regions, thus leading to the preferential detection of fragments originating from unpaired regions. Such effect is determined by the stability of the weak non-covalent association between complementary stretches, which is affected by base composition, length of the double-stranded structure, and charge of the precursor ion selected for analysis. Although such effect may prevent the achievement of full sequence coverage for primary structure determination, it may provide the key to correctly differentiate double- versus single-stranded regions, in what could be defined as gas-phase footprinting experiments. In light of the critical role played by base pairs in defining the higher-order structure of nucleic acids, these approaches will be expected to support an increased utilization of mass spectrometry for the investigation of nucleic acid structure and dynamics. PMID:24027423

  7. Rapid separable analysis of higher order correlators in large-scale structure

    NASA Astrophysics Data System (ADS)

    Fergusson, J. R.; Regan, D. M.; Shellard, E. P. S.

    2012-09-01

    We present an efficient separable approach to the estimation and reconstruction of the bispectrum and the trispectrum from observational (or simulated) large-scale structure data. This is developed from general cosmic microwave background (poly)spectra methods that exploit the fact that the bispectrum and trispectrum in the literature can be represented by a separable mode expansion that converges rapidly (with nmax⁡=O(30) terms). The underlying methodology can encompass a wide variety of modal types, including polynomials, trigonometric functions, wavelets, and bins. With an effective grid resolution lmax⁡ (number of particles/grid points N=lmax⁡3), we present a bispectrum estimator that requires only O(nmax⁡×lmax⁡3) operations, along with a corresponding method for direct bispectrum reconstruction. This method is extended to the trispectrum revealing an estimator that requires only O(nmax⁡4/3×lmax⁡3) operations. The complexity in calculating the trispectrum in this method is now involved in the original decomposition and orthogonalization process that need only be performed once for each model. However, for nondiagonal trispectra these processes present little extra difficulty and may be performed in O(lmax⁡4) operations. A discussion of how the methodology may be applied to the quadspectrum is also given. An efficient algorithm for the generation of arbitrary non-Gaussian initial conditions for use in N-body codes using this separable approach is described. This prescription allows for the production of non-Gaussian initial conditions for arbitrary bispectra and trispectra. A brief outline of the key issues involved in parameter estimation, particularly in the nonlinear regime, is also given.

  8. Higher order turbulence closure models

    NASA Technical Reports Server (NTRS)

    Amano, Ryoichi S.; Chai, John C.; Chen, Jau-Der

    1988-01-01

    Theoretical models are developed and numerical studies conducted on various types of flows including both elliptic and parabolic. The purpose of this study is to find better higher order closure models for the computations of complex flows. This report summarizes three new achievements: (1) completion of the Reynolds-stress closure by developing a new pressure-strain correlation; (2) development of a parabolic code to compute jets and wakes; and, (3) application to a flow through a 180 deg turnaround duct by adopting a boundary fitted coordinate system. In the above mentioned models near-wall models are developed for pressure-strain correlation and third-moment, and incorporated into the transport equations. This addition improved the results considerably and is recommended for future computations. A new parabolic code to solve shear flows without coordinate tranformations is developed and incorporated in this study. This code uses the structure of the finite volume method to solve the governing equations implicitly. The code was validated with the experimental results available in the literature.

  9. Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus.

    PubMed

    Yang, Rui; Kerschner, Jenny L; Gosalia, Nehal; Neems, Daniel; Gorsic, Lidija K; Safi, Alexias; Crawford, Gregory E; Kosak, Steven T; Leir, Shih-Hsing; Harris, Ann

    2016-04-20

    Higher order chromatin structure establishes domains that organize the genome and coordinate gene expression. However, the molecular mechanisms controlling transcription of individual loci within a topological domain (TAD) are not fully understood. The cystic fibrosis transmembrane conductance regulator (CFTR) gene provides a paradigm for investigating these mechanisms.CFTR occupies a TAD bordered by CTCF/cohesin binding sites within which are cell-type-selective cis-regulatory elements for the locus. We showed previously that intronic and extragenic enhancers, when occupied by specific transcription factors, are recruited to the CFTR promoter by a looping mechanism to drive gene expression. Here we use a combination of CRISPR/Cas9 editing of cis-regulatory elements and siRNA-mediated depletion of architectural proteins to determine the relative contribution of structural elements and enhancers to the higher order structure and expression of the CFTR locus. We found the boundaries of the CFTRTAD are conserved among diverse cell types and are dependent on CTCF and cohesin complex. Removal of an upstream CTCF-binding insulator alters the interaction profile, but has little effect on CFTR expression. Within the TAD, intronic enhancers recruit cell-type selective transcription factors and deletion of a pivotal enhancer element dramatically decreases CFTR expression, but has minor effect on its 3D structure. PMID:26673704

  10. Higher-order organization of complex networks.

    PubMed

    Benson, Austin R; Gleich, David F; Leskovec, Jure

    2016-07-01

    Networks are a fundamental tool for understanding and modeling complex systems in physics, biology, neuroscience, engineering, and social science. Many networks are known to exhibit rich, lower-order connectivity patterns that can be captured at the level of individual nodes and edges. However, higher-order organization of complex networks--at the level of small network subgraphs--remains largely unknown. Here, we develop a generalized framework for clustering networks on the basis of higher-order connectivity patterns. This framework provides mathematical guarantees on the optimality of obtained clusters and scales to networks with billions of edges. The framework reveals higher-order organization in a number of networks, including information propagation units in neuronal networks and hub structure in transportation networks. Results show that networks exhibit rich higher-order organizational structures that are exposed by clustering based on higher-order connectivity patterns. PMID:27387949

  11. A Role for LHC1 in Higher Order Structure and Complement Binding of the Cryptococcus neoformans Capsule

    PubMed Central

    Park, Yoon-Dong; Shin, Soowan; Panepinto, John; Ramos, Jeanie; Qiu, Jin; Frases, Susana; Albuquerque, Patricia; Cordero, Radames J. B.; Zhang, Nannan; Himmelreich, Uwe; Beenhouwer, David; Bennett, John E.; Casadevall, Arturo; Williamson, Peter R.

    2014-01-01

    Polysaccharide capsules are important virulence factors for many microbial pathogens including the opportunistic fungus Cryptococcus neoformans. In the present study, we demonstrate an unusual role for a secreted lactonohydrolase of C. neoformans, LHC1 in capsular higher order structure. Analysis of extracted capsular polysaccharide from wild-type and lhc1Δ strains by dynamic and static light scattering suggested a role for the LHC1 locus in altering the capsular polysaccharide, both reducing dimensions and altering its branching, density and solvation. These changes in the capsular structure resulted in LHC1-dependent alterations of antibody binding patterns, reductions in human and mouse complement binding and phagocytosis by the macrophage-like cell line J774, as well as increased virulence in mice. These findings identify a unique molecular mechanism for tertiary structural changes in a microbial capsule, facilitating immune evasion and virulence of a fungal pathogen. PMID:24789368

  12. Examination of the effect of the annealing cation on higher order structures containing guanine or isoguanine repeats

    PubMed Central

    Pierce, Sarah E.; Wang, Junmei; Jayawickramarajah, Janarthanan; Hamilton, Andrew D.; Brodbelt, Jennifer S.

    2010-01-01

    Isoguanine (2-oxo-6-amino-guanine), a natural but non-standard base, exhibits unique self-association properties compared to its isomer, guanine, and results in formation of different higher order DNA structures. In this work, the higher order structures formed by oligonucleotides containing guanine repeats or isoguanine repeats after annealing in solutions containing various cations are evaluated by electrospray ionization mass spectrometry (ESI-MS) and circular dichroism (CD) spectroscopy. The guanine-containing strand (G9) consistently formed quadruplexes upon annealing, whereas the isoguanine strand (Ig9) formed both pentaplexes and quadruplexes depending on the annealing cation. Quadruplex formation with G9 showed some dependence on the identity of the cation present during annealing with high relative quadruplex formation detected with six of ten cations. Analogous annealing experiments with Ig9 resulted in complex formation with all ten cations, and the majority of the resulting complexes were pentaplexes. CD results indicated most of the original complexes survived the desalting process necessary for ESI-MS analysis. In addition, several complexes, especially the pentaplexes, were found to be capable of cation exchange with ammonium ions. Ab initio calculations were conducted for isoguanine tetrads and pentads coordinated with all ten cations to predict the most energetically stable structures of the complexes in the gas phase. The observed preference of forming quadruplexes versus pentaplexes as a function of the coordinated cation can be interpreted by the calculated reaction energies of both the tetrads and pentads in combination with the distortion energies of tetrads. PMID:19746468

  13. Higher-order mode absorption measurement of X-band choke-mode cavities in a radial line structure

    NASA Astrophysics Data System (ADS)

    Zha, Hao; Shi, Jiaru; Wu, Xiaowei; Chen, Huaibi

    2016-04-01

    An experiment is presented to study the higher-order mode (HOM) suppression of X-band choke-mode structures with a vector network analyzer (VNA). Specific radial line disks were built to test the reflection from the corresponding damping load and different choke geometries. The mismatch between the radial lines and the VNA was calibrated through a special multi-short-load calibration method. The measured reflections of different choke geometries showed good agreement with the theoretical calculations and verified the HOM absorption feature of each geometric design.

  14. Higher-order derivative correlations and the alignment of small-scale structures in isotropic numerical turbulence

    NASA Technical Reports Server (NTRS)

    Kerr, R. A.

    1983-01-01

    In a three dimensional simulation higher order derivative correlations, including skewness and flatness factors, are calculated for velocity and passive scalar fields and are compared with structures in the flow. The equations are forced to maintain steady state turbulence and collect statistics. It is found that the scalar derivative flatness increases much faster with Reynolds number than the velocity derivative flatness, and the velocity and mixed derivative skewness do not increase with Reynolds number. Separate exponents are found for the various fourth order velocity derivative correlations, with the vorticity flatness exponent the largest. Three dimensional graphics show strong alignment between the vorticity, rate of strain, and scalar-gradient fields. The vorticity is concentrated in tubes with the scalar gradient and the largest principal rate of strain aligned perpendicular to the tubes. Velocity spectra, in Kolmogorov variables, collapse to a single curve and a short minus 5/3 spectral regime is observed.

  15. Higher order differential-integral microphone arrays.

    PubMed

    Abhayapala, Thushara D; Gupta, Aastha

    2010-05-01

    This paper develops theory to design higher order directional microphone arrays. The proposed higher order designs have similar inter sensor spacings as traditional first and second order differential arrays. The Jacobi-Anger expansion is used to exploit the underlying structure of microphone signals from pairs of closely spaced sensors. Specifically, the difference and sum of these microphone signals are processed to design the novel directional array. PMID:21117719

  16. HOTCFGM-1D: A Coupled Higher-Order Theory for Cylindrical Structural Components with Through-Thickness Functionally Graded Microstructures

    NASA Technical Reports Server (NTRS)

    Pindera, Marek-Jerzy; Aboudi, Jacob

    1998-01-01

    The objective of this three-year project was to develop and deliver to NASA Lewis one-dimensional and two-dimensional higher-order theories, and related computer codes, for the analysis, optimization and design of cylindrical functionally graded materials/structural components for use in advanced aircraft engines (e.g., combustor linings, rotor disks, heat shields, blisk blades). To satisfy this objective, a quasi one-dimensional version of the higher-order theory, HOTCFGM-1D, and four computer codes based on this theory, for the analysis, design and optimization of cylindrical structural components functionally graded in the radial direction were developed. The theory is applicable to thin multi-phased composite shell/cylinders subjected to macroscopically axisymmetric thermomechanical and inertial loading applied uniformly along the axial direction such that the overall deformation is characterized by a constant average axial strain. The reinforcement phases are uniformly distributed in the axial and circumferential directions, and arbitrarily distributed in the radial direction, thereby allowing functional grading of the internal reinforcement in this direction.

  17. Downstream elements of mammalian pre-mRNA polyadenylation signals: primary, secondary and higher-order structures.

    PubMed

    Zarudnaya, Margarita I; Kolomiets, Iryna M; Potyahaylo, Andriy L; Hovorun, Dmytro M

    2003-03-01

    Primary, secondary and higher-order structures of downstream elements of mammalian pre-mRNA polyadenylation signals [poly(A) signals] are re viewed. We have carried out a detailed analysis on our database of 244 human pre-mRNA poly(A) signals in order to characterize elements in their downstream regions. We suggest that the downstream region of the mammalian pre-mRNA poly(A) signal consists of various simple elements located at different distances from each other. Thus, the downstream region is not described by any precise consensus. Searching our database, we found that approximately 80% of pre-mRNAs with the AAUAAA or AUUAAA core upstream elements contain simple downstream elements, consisting of U-rich and/or 2GU/U tracts, the former occurring approximately 2-fold more often than the latter. Approximately one-third of the pre-mRNAs analyzed here contain sequences that may form G-quadruplexes. A substantial number of these sequences are located immediately downstream of the poly(A) signal. A possible role of G-rich sequences in the polyadenylation process is discussed. A model of the secondary structure of the SV40 late pre-mRNA poly(A) signal downstream region is presented. PMID:12595544

  18. Elucidating the higher-order structure of biopolymers by structural probing and mass spectrometry: MS3D

    PubMed Central

    Fabris, Daniele; Yu, Eizadora T.

    2010-01-01

    Chemical probing represents a very versatile alternative for studying the structure and dynamics of substrates that are intractable by established high-resolution techniques. The implementation of MS-based strategies for the characterization of probing products has not only extended the range of applicability to virtually all types of biopolymers, but has also paved the way for the introduction of new reagents that would not have been viable with traditional analytical platforms. As the availability of probing data is steadily increasing on the wings of the development of dedicated interpretation aids, powerful computational approaches have been explored to enable the effective utilization of such information to generate valid molecular models. This combination of factors has contributed to making the possibility of obtaining actual 3D structures by MS-based technologies (MS3D) a reality. Although approaches for achieving structure determination of unknown substrates or assessing the dynamics of known structures may share similar reagents and development trajectories, they clearly involve distinctive experimental strategies, analytical concerns, and interpretation paradigms. This Perspective offers a commentary on methods aimed at obtaining distance constraints for the modeling of full-fledged structures, while highlighting common elements, salient distinctions, and complementary capabilities exhibited by methods employed in dynamics studies. We discuss critical factors to be addressed for completing effective structural determinations and expose possible pitfalls of chemical methods. We survey programs developed for facilitating the interpretation of experimental data and discuss possible computational strategies for translating sparse spatial constraints into all-atom models. Examples are provided to illustrate how the concerted application of very diverse probing techniques can lead to the solution of actual biological substrates. PMID:20648672

  19. DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures

    PubMed Central

    Faller, Michael; Toso, Daniel; Matsunaga, Michio; Atanasov, Ivo; Senturia, Rachel; Chen, Yanqiu; Zhou, Z. Hong; Guo, Feng

    2010-01-01

    DiGeorge critical region 8 (DGCR8) is essential for maturation of microRNAs (miRNAs) in animals. In the cleavage of primary transcripts of miRNAs (pri-miRNAs) by the Drosha nuclease, the DGCR8 protein directly binds and recognizes pri-miRNAs through a mechanism currently controversial. Our previous data suggest that DGCR8 trimerizes upon cooperative binding to pri-mir-30a. However, a separate study proposed a model in which a DGCR8 molecule contacts one or two pri-miRNA molecules using its two double-stranded RNA binding domains. Here, we extensively characterized the interaction between DGCR8 and pri-miRNAs using biochemical and structural methods. First, a strong correlation was observed between the association of DGCR8 with pri-mir-30a and the rate of pri-miRNA processing in vitro. Second, we show that the high binding cooperativity allows DGCR8 to distinguish pri-miRNAs from a nonspecific competitor with subtle differences in dissociation constants. The highly cooperative binding of DGCR8 to a pri-miRNA is mediated by the formation of higher-order structures, most likely a trimer of DGCR8 dimers, on the pri-miRNA. These properties are not limited to its interaction with pri-mir-30a. Furthermore, the amphipathic C-terminal helix of DGCR8 is important both for trimerization of DGCR8 on pri-miRNAs and for the cleavage of pri-miRNAs by Drosha. Finally, our three-dimensional model from electron tomography analysis of the negatively stained DGCR8–pri-mir-30a complex directly supports the trimerization model. Our study provides a molecular basis for recognition of pri-miRNAs by DGCR8. We further propose that the higher-order structures of the DGCR8–pri-miRNA complexes trigger the cleavage of pri-miRNAs by Drosha. PMID:20558544

  20. Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells.

    PubMed

    Hirosue, Akiyuki; Ishihara, Ko; Tokunaga, Kazuaki; Watanabe, Takehisa; Saitoh, Noriko; Nakamoto, Masafumi; Chandra, Tamir; Narita, Masashi; Shinohara, Masanori; Nakao, Mitsuyoshi

    2012-06-01

    Somatic cells can be reset to oncogene-induced senescent (OIS) cells or induced pluripotent stem (iPS) cells by expressing specified factors. The INK4/ARF locus encodes p15(INK4b) , ARF, and p16(INK4a) genes in human chromosome 9p21, the products of which are known as common key reprogramming regulators. Compared with growing fibroblasts, the CCCTC-binding factor CTCF is remarkably up-regulated in iPS cells with silencing of the three genes in the locus and is reversely down-regulated in OIS cells with high expression of p15(INK4b) and p16(INK4a) genes. There are at least three CTCF-enriched sites in the INK4/ARF locus, which possess chromatin loop-forming activities. These CTCF-enriched sites and the p16(INK4a) promoter associate to form compact chromatin loops in growing fibroblasts, while CTCF depletion disrupts the loop structure. Interestingly, the loose chromatin structure is found in OIS cells. In addition, the INK4/ARF locus has an intermediate type of chromatin compaction in iPS cells. These results suggest that senescent cells have distinct higher-order chromatin signature in the INK4/ARF locus. PMID:22340434

  1. Comparability of higher order structure in proteins: chemometric analysis of second-derivative amide I Fourier transform infrared spectra.

    PubMed

    Stockdale, Gregory; Murphy, Brian M; D'Antonio, Jennifer; Manning, Mark Cornell; Al-Azzam, Wasfi

    2015-01-01

    Comparing higher order structure (HOS) in therapeutic proteins is a significant challenge. Previously, we showed that changes in solution conditions produced detectable changes in the second-derivative amide I Fourier transform infrared (FTIR) spectra for a variety of model proteins. Those comparisons utilized vector-based approaches, such as spectral overlap and spectral correlation coefficients to quantify differences between spectra. In this study, chemometric analyses of the same data were performed, to classify samples into different groups based on the solution conditions received. The solution conditions were composed of various combinations of temperature, pH, and salt types. At first, principal component analysis (PCA) was used to visually demonstrate that FTIR spectra respond to changes in solution conditions, which, presumably indicates variations in HOS. This observed when samples from the same solution condition form clusters within a PCA score plot. The second approach, called soft independent modeling of class analogy (SIMCA), was conducted to account for the within-class experimental error for the lysozyme spectra. The DModX values, indicative of the distance of each spectra to their respective class models, was found to be a more sensitive quantitative indicator of changes in HOS, when compared with the modified area of overlap algorithm. The SIMCA approach provides a metric to determine whether new observations do, or do not belong to a particular class or group. Thus, SIMCA is the recommended approach when multiple samples from each condition are available. PMID:25382804

  2. Higher order nonlinear effects on wave structures in a four-component dusty plasma with nonisothermal electrons

    SciTech Connect

    Singh Gill, Tarsem; Bedi, Chanchal; Saini, Nareshpal Singh

    2011-04-15

    The higher order solutions of dust acoustic wave in dusty plasma consisting of positively charged warm adiabatic dust, negatively charged cold dust, and nonisothermally distributed electrons are studied. The Schamel-KdV equation is derived using reductive perturbation method (RPM). RPM is further extended to include the contributions of higher order terms and a generalized KdV equation is derived to observe the deviation from isothermality. Effects of nonisothermal parameter, mass and charge ratio, ratio of ion to electron temperatures, and ratio of dust to ion temperatures have been thoroughly studied. By using the renormalization method of Kodama and Taniuti [J. Phys. Soc. Jpn. 45, 298 (1978)], authors have also discussed characteristics of the dressed solitons.

  3. Exploded view of higher order G-quadruplex structures through click-chemistry assisted single-molecule mechanical unfolding

    PubMed Central

    Selvam, Sangeetha; Yu, Zhongbo; Mao, Hanbin

    2016-01-01

    Due to the long-range nature of high-order interactions between distal components in a biomolecule, transition dynamics of tertiary structures is often too complex to profile using conventional methods. Inspired by the exploded view in mechanical drawing, here, we used laser tweezers to mechanically dissect high-order DNA structures into two constituting G-quadruplexes in the promoter of the human telomerase reverse transcriptase (hTERT) gene. Assisted with click-chemistry coupling, we sandwiched one G-quadruplex with two dsDNA handles while leaving the other unit free. Mechanical unfolding through these handles revealed transition dynamics of the targeted quadruplex in a native environment, which is named as native mechanical segmentation (NMS). Comparison between unfolding of an NMS construct and that of truncated G-quadruplex constructs revealed a quadruplex–quadruplex interaction with 2 kcal/mol stabilization energy. After mechanically targeting the two G-quadruplexes together, the same interaction was observed during the first unfolding step. The unfolding then proceeded through disrupting the weaker G-quadruplex at the 5′-end, followed by the stronger G-quadruplex at the 3′-end via various intermediates. Such a pecking order in unfolding well reflects the hierarchical nature of nucleic acid structures. With surgery-like precisions, we anticipate this NMS approach offers unprecedented perspective to decipher dynamic transitions in complex biomacromolecules. PMID:26626151

  4. Exploded view of higher order G-quadruplex structures through click-chemistry assisted single-molecule mechanical unfolding.

    PubMed

    Selvam, Sangeetha; Yu, Zhongbo; Mao, Hanbin

    2016-01-01

    Due to the long-range nature of high-order interactions between distal components in a biomolecule, transition dynamics of tertiary structures is often too complex to profile using conventional methods. Inspired by the exploded view in mechanical drawing, here, we used laser tweezers to mechanically dissect high-order DNA structures into two constituting G-quadruplexes in the promoter of the human telomerase reverse transcriptase (hTERT) gene. Assisted with click-chemistry coupling, we sandwiched one G-quadruplex with two dsDNA handles while leaving the other unit free. Mechanical unfolding through these handles revealed transition dynamics of the targeted quadruplex in a native environment, which is named as native mechanical segmentation (NMS). Comparison between unfolding of an NMS construct and that of truncated G-quadruplex constructs revealed a quadruplex-quadruplex interaction with 2 kcal/mol stabilization energy. After mechanically targeting the two G-quadruplexes together, the same interaction was observed during the first unfolding step. The unfolding then proceeded through disrupting the weaker G-quadruplex at the 5'-end, followed by the stronger G-quadruplex at the 3'-end via various intermediates. Such a pecking order in unfolding well reflects the hierarchical nature of nucleic acid structures. With surgery-like precisions, we anticipate this NMS approach offers unprecedented perspective to decipher dynamic transitions in complex biomacromolecules. PMID:26626151

  5. Gain analysis of higher-order-mode amplification in a dielectric-implanted multi-beam traveling wave structure

    SciTech Connect

    Gee, Anthony; Shin, Young-Min; Accelerator Physics Center , Fermi National Accelerator Laboratory , Batavia, Illinois 60510

    2013-07-15

    A multi-beam traveling wave amplifier designed with an overmoded staggered double grating array was examined by small signal analysis combined with simulation. Eigenmode and S-parameter analyses show that the 2 cm long slow wave structure (SWS) has 1–5 dB insertion loss over the passband (TM{sub 31} mode) with ∼28% cold bandwidth. Analytic gain calculation indicates that in the SWS, TM{sub 31}-mode is amplified with 15–20 dB/beam at 64–84 GHz with three elliptical beams of 10 kV and 150 mA/beam, which was compared with particle-in-cell (PIC) simulations. PIC analysis on the analysis of instability with zero-input driving excitations demonstrated that background noises and non-operating lower order modes are noticeably suppressed by implanting equidistant dielectric absorbers; the overmoded structure only allowed the desired 3rd order mode to propagate in the structure. The designed circuit structure can be widely applied to multi-beam devices for high power RF generation.

  6. Gain analysis of higher-order-mode amplification in a dielectric-implanted multi-beam traveling wave structure

    SciTech Connect

    Gee, Anthony; Shin, Young-Min

    2013-01-01

    A multi-beam traveling wave amplifier designed with an overmoded staggered double grating array was examined by small signal analysis combined with simulation. Eigenmode and S-parameter analyses show that the 2cm long slow wave structure (SWS) has 1-5dB insertion loss over the passband (TM31 mode) with ~28% cold bandwidth. Analytic gain calculation indicates that in the SWS, TM31-mode is amplified with 15–20 dB/beam at 64–84GHz with three elliptical beams of 10kV and 150mA/beam, which was compared with particle-in-cell (PIC) simulations. PIC analysis on the analysis of instability with zero-input driving excitations demonstrated that background noises and non-operating lower order modes are noticeably suppressed by implanting equidistant dielectric absorbers; the overmoded structure only allowed the desired 3rd order mode to propagate in the structure. The designed circuit structure can be widely applied to multi-beam devices for high power RF generation.

  7. Analogy, higher order thinking, and education.

    PubMed

    Richland, Lindsey Engle; Simms, Nina

    2015-01-01

    Analogical reasoning, the ability to understand phenomena as systems of structured relationships that can be aligned, compared, and mapped together, plays a fundamental role in the technology rich, increasingly globalized educational climate of the 21st century. Flexible, conceptual thinking is prioritized in this view of education, and schools are emphasizing 'higher order thinking', rather than memorization of a cannon of key topics. The lack of a cognitively grounded definition for higher order thinking, however, has led to a field of research and practice with little coherence across domains or connection to the large body of cognitive science research on thinking. We review literature on analogy and disciplinary higher order thinking to propose that relational reasoning can be productively considered the cognitive underpinning of higher order thinking. We highlight the utility of this framework for developing insights into practice through a review of mathematics, science, and history educational contexts. In these disciplines, analogy is essential to developing expert-like disciplinary knowledge in which concepts are understood to be systems of relationships that can be connected and flexibly manipulated. At the same time, analogies in education require explicit support to ensure that learners notice the relevance of relational thinking, have adequate processing resources available to mentally hold and manipulate relations, and are able to recognize both the similarities and differences when drawing analogies between systems of relationships. PMID:26263071

  8. Higher-order dielectrophoresis of nonspherical particles

    NASA Astrophysics Data System (ADS)

    Nili, Hossein; Green, Nicolas G.

    2014-06-01

    Higher-order terms of dielectrophoretic (DEP) force are commonly ignored by invoking the simplifying dipole approximation. Concurrently, the trend towards micro- and nano-electrode structures in DEP design is bringing about an increasing number of instances where the approximation is expected to lose reliability. The case is severe for nonspherical particles (the shape of many biological particles) due to the shape-dependent nature of dielectric polarization. However, there is a lack of analytical means to determine multipole moments of nonspherical particles, numerical calculations of the same are regarded as unreliable, and there is a prevalence for higher-order force considerations to be ignored. As a result, the dipole approximation is used and/or nonspherical particles are approximated as spheres. This work proves the inefficacy of current qualitative criteria for the reliability of the dipole approximation and presents a quantitative substitute, with verified accuracy, that enables precise determination of the extent to which the dipole approximation would be reliable, and if found unreliable, corrects the approximation by adding second- and third-order terms of the DEP force. The effects of field nonuniformity, electrode design, and particle shape and aspect ratio on the significance of higher-order DEP forces is quantitatively analyzed. The results show that higher-order DEP forces are indeed of substantially increased significance for nonspherical particles; in the cases examined in this work, multipolar terms are seen to constitute more than 40% of the total force on ellipsoidal and cylindrical particles. It is further shown that approximating nonspherical particles as spheres of similar dimensions is subject to substantial error. Last, the substantial importance of the electrode design in influencing higher-order forces is shown.

  9. Higher order architecture of collections of objects

    NASA Astrophysics Data System (ADS)

    Baas, Nils A.

    2015-01-01

    We show that on an arbitrary collection of objects there is a wide variety of higher order architectures governed by hyperstructures. Higher order gluing, local to global processes, fusion of collections, bridges and higher order types are discussed. We think that these types of architectures may have interesting applications in many areas of science.

  10. Higher-Order Factors in Structure-of-Intellect (SOI) Aptitude Tests Hypothesized to Portray Constructs of Military Leadership: A Re-analysis of an SOI Data Base.

    ERIC Educational Resources Information Center

    Ulosevich, Steven N.; And Others

    1991-01-01

    A correlation matrix of 21 structure-of-intellect (SOI) tests taken by 204 Marine officers at a military base in Southern California, which was intended to reflect aptitudes for military leadership, was reanalyzed through exploratory factor analysis and confirmatory maximum likelihood factor analysis. Higher order factors appeared to have…

  11. Investigation of the Factor Structure of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV): Exploratory and Higher Order Factor Analyses

    ERIC Educational Resources Information Center

    Canivez, Gary L.; Watkins, Marley W.

    2010-01-01

    The present study examined the factor structure of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV; D. Wechsler, 2008a) standardization sample using exploratory factor analysis, multiple factor extraction criteria, and higher order exploratory factor analysis (J. Schmid & J. M. Leiman, 1957) not included in the WAIS-IV Technical and…

  12. Crystallographic Studies on the Mechanisms of the Cluster Formation and the Higher Order Structure Evolution of Mixed-valence Polyoxometalates

    NASA Astrophysics Data System (ADS)

    Ozeki, Tomoji

    The advantages of the use of synchrotron radiation for single crystal X-ray diffraction experiments were exploited to obtain a deeper understanding of the chemistry of polyoxometalates through structural investigations. The pH dependence of the structures of {Mo154-x} mixed-valence oxomolybdate clusters were investigated by analyzing the structures of systematically prepared compounds containing wheel-shaped mixed-valence polyoxometalates with 138, 142, 148, 150, or 152 molybdenum atoms. Direct correlation was observed between the nuclearity of the clusters with the pH of the mother liquor. On the other hand, the geometries of extended structures do not show apparent correlation with the pH. They turned out to be determined by the structures of the constituent polyoxometalate. The pH of the mother liquor exerts influence on the extended structure through the structures of the constituent clusters. Such systematic preparation—structure determination study was enabled by the use of synchrotron radiation.

  13. Resonant radiation from oscillating higher order solitons.

    PubMed

    Driben, R; Yulin, A V; Efimov, A

    2015-07-27

    We present radiation mechanism exhibited by a higher order soliton. In a course of its evolution the higher-order soliton emits polychromatic radiation resulting in formation of multipeak frequency comb-like spectral band. The shape and spectral position of this band can be effectively controlled by the relative strength of the third order dispersion. An analytical description is corroborated by numerical simulations. It is shown that for longer pulses the described effect persists also under the action of higher order perturbations such as Raman and self-steepening. PMID:26367574

  14. Resonant radiation from oscillating higher order solitons

    SciTech Connect

    Driben, R.; Yulin, A. V.; Efimov, A.

    2015-07-15

    We present radiation mechanism exhibited by a higher order soliton. In a course of its evolution the higher-order soliton emits polychromatic radiation resulting in formation of multipeak frequency comb-like spectral band. The shape and spectral position of this band can be effectively controlled by the relative strength of the third order dispersion. An analytical description is corroborated by numerical simulations. Research showed that for longer pulses the described effect persists also under the action of higher order perturbations such as Raman and self-steepening.

  15. Higher order Godunov schemes for isothermal hydrodynamics

    NASA Technical Reports Server (NTRS)

    Balsara, Dinshaw S.

    1994-01-01

    In this paper we construct higher order Godunov schemes for isothermal flow. Isothermal hydrodynamics serves as a good representation for several systems of astrophysical interest. The schemes designed here have second-order accuracy in space and time and some are third-order accurate for advection. Moreover, several ingredients of these schemes are essential components of even higher order. The methods designed here have excellent ability to represent smooth flow yet capture shocks with high resolution. Several test problems are presented. The algorithms presented here are compared with other algorithms having a comparable formal order of accuracy.

  16. Orthogonal Higher Order Structure and Confirmatory Factor Analysis of the French Wechsler Adult Intelligence Scale (WAIS-III)

    ERIC Educational Resources Information Center

    Golay, Philippe; Lecerf, Thierry

    2011-01-01

    According to the most widely accepted Cattell-Horn-Carroll (CHC) model of intelligence measurement, each subtest score of the Wechsler Intelligence Scale for Adults (3rd ed.; WAIS-III) should reflect both 1st- and 2nd-order factors (i.e., 4 or 5 broad abilities and 1 general factor). To disentangle the contribution of each factor, we applied a…

  17. Factor Structure and Validity of Paper-and-Pencil Measures of Mental Speed: Evidence for a Higher-Order Model?

    ERIC Educational Resources Information Center

    Danthiir, Vanessa; Wilhelm, Oliver; Schulze, Ralf; Roberts, Richard D.

    2005-01-01

    This study explored the structure of elementary cognitive tasks (ECTs) and relations between the corresponding construct(s) with processing speed (Gs) and fluid intelligence (Gf). Participants (N=321) completed 14 ECTs, 3 Gs, and 6 Gf marker tests, all administered in paper-and-pencil format to reduce potential confounds evident when tasks are…

  18. Higher-Order Factor Structure of the Differential Ability Scales-II: Consistency across Ages 4 to 17

    ERIC Educational Resources Information Center

    Keith, Timothy Z.; Low, Justin A.; Reynolds, Matthew R.; Patel, Puja G.; Ridley, Kristen P.

    2010-01-01

    The recently published second edition of the Differential Abilities Scale (DAS-II) is designed to measure multiple broad and general abilities from Cattell-Horn-Carroll (CHC) theory. Although the technical manual presents information supporting the test's structure, additional research is needed to determine the constructs measured by the test and…

  19. A cross-cultural study of the higher-order structures underlying personality disorders in French-speaking Africa and Switzerland.

    PubMed

    Rigozzi, Christine; Rossier, Jérôme; Dahourou, Donatien; Adjahouisso, Marcel; Ah-Kion, Jennifer; Amoussou-Yeye, Denis; Barry, Oumar; Bhowon, Uma; Bouatta, Cherifa; Cissé, Daouda Dougoumalé; Mbodji, Mamadou; Meyer de Stadelhofen, Franz; Minga, David Minga; Tseung, Caroline Ng; Ondongo, François; Romdhane, Mohamed Nouri; Sfayhi, Nicole; Tsokini, Dieudonné; Verardi, Sabrina

    2009-04-01

    Most studies about the higher-order dimensions to be considered in order to parsimoniously describe Personality Disorders (PDs) have identified between two and four factors but there is still no consensus about their exact number. In this context, the cultural stability of these structures might be a criterion to be considered. The aim of this study was to identify stable higher-order structures of PD traits in a French-speaking African and Swiss sample (N = 2,711). All subjects completed the IPDE screening questionnaire. Using Everett's criterion and conducting a series of principal component analyses, a cross-culturally stable two- and four-factor structure were identified, associated with a total congruence coefficient of .98 and .94, respectively, after Procrustes rotation. Moreover, these two structures were also highly replicable across the four African regions considered, North Africa, West Africa, Central Africa, and Mauritius, with a mean total congruence coefficient of .97 and .87, respectively. The four-factor structure presented the advantage of being similar to Livesely's four components and of describing the ten PDs more accurately. PMID:19379094

  20. Applicability/evaluation of flux based representations for linear/higher order elements for heat transfer in structures - Generalized gamma(T)-family

    NASA Technical Reports Server (NTRS)

    Namburu, R. R.; Tamma, K. K.

    1991-01-01

    The applicability and evaluation of a generalized gamma(T) family of flux-based representations are examined for two different thermal analysis formulations for structures and materials which exhibit no phase change effects. The so-called H-theta and theta forms are demonstrated for numerous test models and linear and higher-order elements. The results show that the theta form with flux-based representations is generally superior to traditional approaches.

  1. Extreme brain events: Higher-order statistics of brain resting activity and its relation with structural connectivity

    NASA Astrophysics Data System (ADS)

    Amor, T. A.; Russo, R.; Diez, I.; Bharath, P.; Zirovich, M.; Stramaglia, S.; Cortes, J. M.; de Arcangelis, L.; Chialvo, D. R.

    2015-09-01

    The brain exhibits a wide variety of spatiotemporal patterns of neuronal activity recorded using functional magnetic resonance imaging as the so-called blood-oxygenated-level-dependent (BOLD) signal. An active area of work includes efforts to best describe the plethora of these patterns evolving continuously in the brain. Here we explore the third-moment statistics of the brain BOLD signals in the resting state as a proxy to capture extreme BOLD events. We find that the brain signal exhibits typically nonzero skewness, with positive values for cortical regions and negative values for subcortical regions. Furthermore, the combined analysis of structural and functional connectivity demonstrates that relatively more connected regions exhibit activity with high negative skewness. Overall, these results highlight the relevance of recent results emphasizing that the spatiotemporal location of the relatively large-amplitude events in the BOLD time series contains relevant information to reproduce a number of features of the brain dynamics during resting state in health and disease.

  2. Using Reflection to Develop Higher Order Processes

    ERIC Educational Resources Information Center

    Lerch, Carol; Bilics, Andrea; Colley, Binta

    2006-01-01

    The main purpose of this study was to look at how we used specific writing assignments in our courses to encourage metacognitive reflection in order to increase the learning that takes place. The study also aimed to aid in the development of higher order processing skills through the development of student reflection. The students involved in the…

  3. Higher-Order Neural Networks Recognize Patterns

    NASA Technical Reports Server (NTRS)

    Reid, Max B.; Spirkovska, Lilly; Ochoa, Ellen

    1996-01-01

    Networks of higher order have enhanced capabilities to distinguish between different two-dimensional patterns and to recognize those patterns. Also enhanced capabilities to "learn" patterns to be recognized: "trained" with far fewer examples and, therefore, in less time than necessary to train comparable first-order neural networks.

  4. Human motion perception: Higher-order organization

    NASA Technical Reports Server (NTRS)

    Kaiser, Mary K.; Proffitt, Dennis R.

    1990-01-01

    An overview is given of higher-order motion perception and organization. It is argued that motion is sufficient to fully specify a number of environmental properties, including: depth order, three-dimensional form, object displacement, and dynamics. A grammar of motion perception is proposed; applications of this work for display design are discussed.

  5. Higher-order awareness, misrepresentation and function

    PubMed Central

    Rosenthal, David

    2012-01-01

    Conscious mental states are states we are in some way aware of. I compare higher-order theories of consciousness, which explain consciousness by appeal to such higher-order awareness (HOA), and first-order theories, which do not, and I argue that higher-order theories have substantial explanatory advantages. The higher-order nature of our awareness of our conscious states suggests an analogy with the metacognition that figures in the regulation of psychological processes and behaviour. I argue that, although both consciousness and metacognition involve higher-order psychological states, they have little more in common. One thing they do share is the possibility of misrepresentation; just as metacognitive processing can misrepresent one's cognitive states and abilities, so the HOA in virtue of which one's mental states are conscious can, and sometimes does, misdescribe those states. A striking difference between the two, however, has to do with utility for psychological processing. Metacognition has considerable benefit for psychological processing; in contrast, it is unlikely that there is much, if any, utility to mental states' being conscious over and above the utility those states have when they are not conscious. PMID:22492758

  6. Higher-order awareness, misrepresentation and function.

    PubMed

    Rosenthal, David

    2012-05-19

    Conscious mental states are states we are in some way aware of. I compare higher-order theories of consciousness, which explain consciousness by appeal to such higher-order awareness (HOA), and first-order theories, which do not, and I argue that higher-order theories have substantial explanatory advantages. The higher-order nature of our awareness of our conscious states suggests an analogy with the metacognition that figures in the regulation of psychological processes and behaviour. I argue that, although both consciousness and metacognition involve higher-order psychological states, they have little more in common. One thing they do share is the possibility of misrepresentation; just as metacognitive processing can misrepresent one's cognitive states and abilities, so the HOA in virtue of which one's mental states are conscious can, and sometimes does, misdescribe those states. A striking difference between the two, however, has to do with utility for psychological processing. Metacognition has considerable benefit for psychological processing; in contrast, it is unlikely that there is much, if any, utility to mental states' being conscious over and above the utility those states have when they are not conscious. PMID:22492758

  7. Interaction of chromatin with NaCl and MgCl2. Solubility and binding studies, transition to and characterization of the higher-order structure.

    PubMed

    Ausio, J; Borochov, N; Seger, D; Eisenberg, H

    1984-08-15

    Chicken erythrocyte chromatin containing histones H1 and H5 was carefully separated into a number of well-characterized fractions. A distinction could be made between chromatin insoluble in NaCl above about 80 mM, and chromatin soluble at all NaCl concentrations. Both chromatin forms were indistinguishable electrophoretically and both underwent the transition from the low salt "10 nm" coil to the "30 nm" higher-order structure solenoid by either raising the MgCl2 concentration to about 0.3 mM or the NaCl concentration to about 75 mM. The transitions were examined in detail by elastic light-scattering procedures. It could be shown that the 10 nm form is a flexible coil. For the 30 nm solenoid, the assumption of a rigid cylindrical structure was in good agreement with 5.7 nucleosomes per helical turn. However, disagreement of calculated frictional parameters with values derived from quasielastic light-scattering and sedimentation introduced the possibility that the higher-order structure, under these conditions, is more extended, flexible, or perhaps a mixture of structures. Values for density and refractive index increments of chromatin are also given. To understand the interaction of chromatin with NaCl and with MgCl2, a number of experiments were undertaken to study solubility, precipitation, conformational transitions and binding of ions over a wide range of experimental conditions, including chromatin concentration. PMID:6471101

  8. The exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium.

    PubMed

    Saintomé, Carole; Amrane, Samir; Mergny, Jean-Louis; Alberti, Patrizia

    2016-04-01

    DNA and RNA guanine-quadruplexes (G4s) are stabilized by several cations, in particular by potassium and sodium ions. Generally, potassium stabilizes guanine-quartet assemblies to a larger extent than sodium; in this article we report about a higher-order G4 structure more stable in sodium than in potassium. Repeats of the DNA GGGTTA telomeric motif fold into contiguous G4 units. Using three independent approaches (thermal denaturation experiments, isothermal molecular-beacon and protein-binding assays), we show that the (GGGTTA)7GGG sequence, folding into two contiguous G4 units, exhibits an unusual feature among G4 motifs: despite a lower thermal stability, its sodium conformation is more stable than its potassium counterpart at physiological temperature. Using differential scanning calorimetry and mutated sequences, we show that this switch in the relative stability of the sodium and potassium conformations (occurring around 45 °C in 100 mM cation concentration) is the result of a more favorable enthalpy change upon folding in sodium, generated by stabilizing interactions between the two G4 units in the sodium conformation. Our work demonstrates that interactions between G4 structural domains can make a higher-order structure more stable in sodium than in potassium, even though its G4 structural domains are individually more stable in potassium than in sodium. PMID:26762980

  9. The exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium

    PubMed Central

    Saintomé, Carole; Amrane, Samir; Mergny, Jean-Louis; Alberti, Patrizia

    2016-01-01

    DNA and RNA guanine-quadruplexes (G4s) are stabilized by several cations, in particular by potassium and sodium ions. Generally, potassium stabilizes guanine-quartet assemblies to a larger extent than sodium; in this article we report about a higher-order G4 structure more stable in sodium than in potassium. Repeats of the DNA GGGTTA telomeric motif fold into contiguous G4 units. Using three independent approaches (thermal denaturation experiments, isothermal molecular-beacon and protein-binding assays), we show that the (GGGTTA)7GGG sequence, folding into two contiguous G4 units, exhibits an unusual feature among G4 motifs: despite a lower thermal stability, its sodium conformation is more stable than its potassium counterpart at physiological temperature. Using differential scanning calorimetry and mutated sequences, we show that this switch in the relative stability of the sodium and potassium conformations (occurring around 45°C in 100 mM cation concentration) is the result of a more favorable enthalpy change upon folding in sodium, generated by stabilizing interactions between the two G4 units in the sodium conformation. Our work demonstrates that interactions between G4 structural domains can make a higher-order structure more stable in sodium than in potassium, even though its G4 structural domains are individually more stable in potassium than in sodium. PMID:26762980

  10. Second- and higher-order structural changes of DNA induced by antitumor-active tetrazolato-bridged dinuclear platinum(II) complexes with different types of 5-substituent.

    PubMed

    Uemura, Masako; Yoshikawa, Yuko; Yoshikawa, Kenichi; Sato, Takaji; Mino, Yoshiki; Chikuma, Masahiko; Komeda, Seiji

    2013-10-01

    Here, we used circular dichroism (CD) and fluorescence microscopy (FM) to examine the interactions of a series of antitumor-active tetrazolato-bridged dinuclear platinum(II) complexes, [{cis-Pt(NH3)2}2(μ-OH)(μ-5-R-tetrazolato-N2,N3)](n+) (R=CH3 (1), C6H5 (2), CH2COOCH2CH3 (3), CH2COO(-) (4), n=2 (1-3) or 1 (4)), which are derivatives of [{cis-Pt(NH3)2}2(μ-OH)(μ-tetrazolato-N2,N3)](2+) (5-H-Y), with DNA to elucidate the influence of these interactions on the secondary or higher-order structure of DNA and reveal the mechanism of action. The CD study showed that three derivatives, 1-3, with a double-positive charge altered the secondary structures of calf thymus DNA but that 4, the only complex with a single positive charge, induced almost no change, implying that the B- to C-form conformational change is influenced by ionic attraction. Unexpectedly, single-molecule observations with FM revealed that 4 changed the higher-order structure of T4 DNA into the compact-globule state most efficiently, at the lowest concentration, which was nearly equal to that of 5-H-Y. These contradictory results suggest that secondary structural changes are not necessarily linked to higher-order ones, and that the non-coordinative interaction could be divided into two distinct interactions: (1) ionic attraction and (2) hydrogen bonding and/or van der Waals contact. The relationship between diffusion-controlled non-coordinative DNA interactions and cytotoxicities is also discussed. PMID:23725767

  11. Higher Order Thermal Lattice Boltzmann Model

    NASA Astrophysics Data System (ADS)

    Sorathiya, Shahajhan; Ansumali, Santosh

    2013-03-01

    Lattice Boltzmann method (LBM) modelling of thermal flows, compressible and micro flows requires an accurate velocity space discretization. The sub optimality of Gauss-Hermite quadrature in this regard is well known. Most of the thermal LBM in the past have suffered from instability due to lack of proper H-theorem and accuracy. Motivated from these issues, the present work develops along the two works and and imposes an eighth higher order moment to get correct thermal physics. We show that this can be done by adding just 6 more velocities to D3Q27 model and obtain a ``multi-speed on lattice thermal LBM'' with 33 velocities in 3D and calO (u4) and calO (T4) accurate fieq with a consistent H-theorem and inherent numerical stability. Simulations for Rayleigh-Bernard as well as velocity and temperature slip in micro flows matches with analytical results. Lid driven cavity set up for grid convergence is studied. Finally, a novel data structure is developed for HPC. The authors express their gratitude for computational resources and financial support provide by Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India.

  12. Breastfeeding twins and higher-order multiples.

    PubMed

    Gromada, K K; Spangler, A K

    1998-01-01

    The benefits of breastfeeding for pre-term and full-term infants are well documented. Breastfeeding facilitates maternal-infant attachment, provides optimal infant nutrition and immunologic protection, and minimizes economic impact. These benefits are multiplied with twins and higher-order multiples, who often are born at risk. Supporting a mother as she initiates and continues to breastfeed one infant requires specific knowledge and skills. Health professionals need additional knowledge and skills if they are to provide appropriate assessment, intervention, and support when a mother breastfeeds twins or higher-order multiples. PMID:9684207

  13. Real-time object recognition in multidimensional images based on joined extended structural tensor and higher-order tensor decomposition methods

    NASA Astrophysics Data System (ADS)

    Cyganek, Boguslaw; Smolka, Bogdan

    2015-02-01

    In this paper a system for real-time recognition of objects in multidimensional video signals is proposed. Object recognition is done by pattern projection into the tensor subspaces obtained from the factorization of the signal tensors representing the input signal. However, instead of taking only the intensity signal the novelty of this paper is first to build the Extended Structural Tensor representation from the intensity signal that conveys information on signal intensities, as well as on higher-order statistics of the input signals. This way the higher-order input pattern tensors are built from the training samples. Then, the tensor subspaces are built based on the Higher-Order Singular Value Decomposition of the prototype pattern tensors. Finally, recognition relies on measurements of the distance of a test pattern projected into the tensor subspaces obtained from the training tensors. Due to high-dimensionality of the input data, tensor based methods require high memory and computational resources. However, recent achievements in the technology of the multi-core microprocessors and graphic cards allows real-time operation of the multidimensional methods as is shown and analyzed in this paper based on real examples of object detection in digital images.

  14. Higher-order structure of bovine mitochondrial tRNA(Phe) lacking the 'conserved' GG and T psi CG sequences as inferred by enzymatic and chemical probing.

    PubMed Central

    Wakita, K; Watanabe, Y; Yokogawa, T; Kumazawa, Y; Nakamura, S; Ueda, T; Watanabe, K; Nishikawa, K

    1994-01-01

    Bovine mitochondrial (mt) phenylalanine tRNA (tRNA(Phe)), which lacks the 'conserved' GG and T psi YCG sequences, was efficiently purified by the selective hybridization method using a solid phase DNA probe. The entire nucleotide sequence of the tRNA, including modified nucleotides, was determined and its higher-order structure was investigated using RNaseT2 and chemical reagents as structural probes. The D and T loop regions as well as the anticodon loop region were accessible to RNaseT2, and the N-3 positions of cytidines present in the D and T loops were easily modified under the native conditions in the presence of 10mM Mg2+. On the other hand, the nucleotides present in the extra loop were protected from the chemical modification under the native conditions. From the results of these probing analyses and a comparison of the sequences of mitochondrial tRNA(Phe) genes from various organisms, it was inferred that bovine mt tRNA(Phe) lacks the D loop/T loop tertiary interactions, but does have the canonical extra loop/D stem interactions, which seem to be the main factor for bovine mt tRNA(Phe) to preserve its L-shaped higher-order structure. Images PMID:7510390

  15. Subzero temperature chromatography and top-down mass spectrometry for protein higher-order structure characterization: method validation and application to therapeutic antibodies.

    PubMed

    Pan, Jingxi; Zhang, Suping; Parker, Carol E; Borchers, Christoph H

    2014-09-17

    Characterization of the higher-order structure and structural dynamics of proteins is crucial for in-depth understanding of their functions. Amide hydrogen/deuterium exchange (HDX), monitored by mass spectrometry (MS), is now a popular technique for measuring protein higher-order structural changes. Although the proteolysis-based HDX-MS approach is most commonly used, the "top-down" approach, which fragments intact proteins directly using electron-based dissociation, is becoming an important alternative and has several advantages. However, the commonly used top-down strategies are direct-infusion based and thus can only be used with volatile buffers. This has meant that the "top-down" approach could not be used for studying proteins under physiological conditions-the very conditions which are often very important for preserving a protein's native structure and function. More complex proteins such as those with disulfide bonds present another challenge. Therefore, there is significant interest in developing novel top-down HDX methods that are applicable to all types of protein samples. In this paper, we show how top-down electron capture dissociation and subzero temperature HPLC can be combined and used for this purpose. This method keeps the back-exchange level as low as 2% and has no limitations in terms of protein type and sample solution conditions. Close to single-residue level protein structural information can be generated. The new method is validated through comparison with NMR data using calmodulin as a model protein. Its capability of determining structural changes in therapeutic antibodies (Herceptin) is also demonstrated. PMID:25152011

  16. Modulational instability, higher-order localized wave structures, and nonlinear wave interactions for a nonautonomous Lenells-Fokas equation in inhomogeneous fibers.

    PubMed

    Wang, Lei; Zhu, Yu-Jie; Qi, Feng-Hua; Li, Min; Guo, Rui

    2015-06-01

    In this paper, the nonautonomous Lenells-Fokas (LF) model is investigated. The modulational instability analysis of the solutions with variable coefficients in the presence of a small perturbation is studied. Higher-order soliton, breather, earthwormon, and rogue wave solutions of the nonautonomous LF model are derived via the n-fold variable-coefficient Darboux transformation. The solitons and earthwormons display the elastic collisions. It is found that the nonautonomous LF model admits the higher-order periodic rogue waves, composite rogue waves (rogue wave pair), and oscillating rogue waves, whose dynamics can be controlled by the inhomogeneous nonlinear parameters. Based on the second-order rogue wave, a diamond structure consisting of four first-order rogue waves is observed. In addition, the semirational solutions (the mixed rational-exponential solutions) of the nonautonomous LF model are obtained, which can be used to describe the interactions between the rogue waves and breathers. Our results could be helpful for the design of experiments in the optical fiber communications. PMID:26117105

  17. Higher Order Thinking in the Dance Studio

    ERIC Educational Resources Information Center

    Moffett, Ann-Thomas

    2012-01-01

    The author identifies higher order thinking as an essential component of dance training for students of all ages and abilities. Weaving together insights from interviews with experts in the field of dance education with practical pedagogical applications within an Improvisation and Composition class for talented and gifted youth, this article…

  18. Assessing Higher Order Thinking in Mathematics.

    ERIC Educational Resources Information Center

    Kulm, Gerald, Ed.

    This book explores current theory, research, practice, and policy in the assessment of higher order thinking in mathematics, focusing on the elementary and secondary grades. Current knowledge and research on mathematics learning and testing is synthesized. Examples of innovative test items for classroom use and state assessment programs are…

  19. Enhanced higher order parametric x radiation production

    NASA Astrophysics Data System (ADS)

    Dinova, Kay L.

    1992-12-01

    This thesis examines parametric x-radiation (PXR) which is the Bragg scattering of the virtual photons associated with the Coulomb field of relativistic charged particle from the atomic planes of a crystal. Higher order parametric x-radiation from the (002) planes of a thick mosaic graphite crystal have been observed. The raw PXR data was collected using a SiLi detector and a Pulse Height Analyzer (PHA) software program. The data was corrected for various effects including attenuation, detector drift, and efficiency. The absolute number of photons per electron was obtained by using the fluorescent x-ray yield from a tin foil backing on the graphite crystal to determine the LINAC current. The number of photons per electron observed greatly exceeds the expected values. Comparison of the ratio of intensity of a given order to the first order I(n)/I(I) to the theoretical ratio shows that the ratios increase with order. Not only is the absolute intensity greater than expected, but the higher orders (compared to the first order) are larger than expected. Lastly, the intensity for various crystal angle orientations and a fixed detector angle was measured.

  20. Simulation Higher Order Language Requirements Study.

    ERIC Educational Resources Information Center

    Goodenough, John B.; Braun, Christine L.

    The definitions provided for high order language (HOL) requirements for programming flight training simulators are based on the analysis of programs written for a variety of simulators. Examples drawn from these programs are used to justify the need for certain HOL capabilities. A description of the general structure and organization of the…

  1. The regular state in higher order gravity

    NASA Astrophysics Data System (ADS)

    Cotsakis, Spiros; Kadry, Seifedine; Trachilis, Dimitrios

    2016-08-01

    We consider the higher-order gravity theory derived from the quadratic Lagrangian R + 𝜖R2 in vacuum as a first-order (ADM-type) system with constraints, and build time developments of solutions of an initial value formulation of the theory. We show that all such solutions, if analytic, contain the right number of free functions to qualify as general solutions of the theory. We further show that any regular analytic solution which satisfies the constraints and the evolution equations can be given in the form of an asymptotic formal power series expansion.

  2. Performance assessment of higher order thinking.

    PubMed

    Griffin, Patrick

    2014-01-01

    This article describes a study investigating the effect of intervention on student problem solving and higher order competency development using a series of complex numeracy performance tasks (Airasian and Russell, 2008). The tasks were sequenced to promote and monitor student development towards hypothetico-deductive reasoning. Using Rasch partial credit analysis (Wright and Masters, 1982) to calibrate the tasks and analysis of residual gain scores to examine the effect of class and school membership, the study illustrates how directed intervention can improve students' higher order competency skills. This paper demonstrates how the segmentation defined by Wright and Masters can offer a basis for interpreting the construct underlying a test and how segment definitions can deliver targeted interventions. Implications for teacher intervention and teaching mentor schemes are considered. The article also discusses multilevel regression models that differentiate class and school effects, and describes a process for generating, testing and using value added models. PMID:24518581

  3. Higher-Order Mentalising and Executive Functioning

    PubMed Central

    2015-01-01

    Higher-order mentalising is the ability to represent the beliefs and desires of other people at multiple, iterated levels – a capacity that sets humans apart from other species. However, there has not yet been a systematic attempt to determine what cognitive processes underlie this ability. Here we present three correlational studies assessing the extent to which performance on higher-order mentalising tasks relates to emotion recognition, self-reported empathy and self-inhibition. In Study 1a and 1b, examining emotion recognition and empathy, a relationship was identified between individual differences in the ability to mentalise and an emotion recognition task (the Reading the Mind in the Eyes task), but no correlation was found with the Empathy Quotient, a self-report scale of empathy. Study 2 investigated whether a relationship exists between individual mentalising abilities and four different forms of self-inhibition: motor inhibition, executive inhibition, automatic imitation and temporal discounting. Results demonstrate that only temporal discounting performance relates to mentalising ability; suggesting that cognitive skills relevant to representation of the minds of others’ are not influenced by the ability to perform more basic inhibition. Higher-order mentalising appears to rely on the cognitive architecture that serves both low-level social cognition (emotion recognition), and complex forms of inhibition. PMID:26543298

  4. Visualizing higher order finite elements. Final report

    SciTech Connect

    Thompson, David C; Pebay, Philippe Pierre

    2005-11-01

    This report contains an algorithm for decomposing higher-order finite elements into regions appropriate for isosurfacing and proves the conditions under which the algorithm will terminate. Finite elements are used to create piecewise polynomial approximants to the solution of partial differential equations for which no analytical solution exists. These polynomials represent fields such as pressure, stress, and momentum. In the past, these polynomials have been linear in each parametric coordinate. Each polynomial coefficient must be uniquely determined by a simulation, and these coefficients are called degrees of freedom. When there are not enough degrees of freedom, simulations will typically fail to produce a valid approximation to the solution. Recent work has shown that increasing the number of degrees of freedom by increasing the order of the polynomial approximation (instead of increasing the number of finite elements, each of which has its own set of coefficients) can allow some types of simulations to produce a valid approximation with many fewer degrees of freedom than increasing the number of finite elements alone. However, once the simulation has determined the values of all the coefficients in a higher-order approximant, tools do not exist for visual inspection of the solution. This report focuses on a technique for the visual inspection of higher-order finite element simulation results based on decomposing each finite element into simplicial regions where existing visualization algorithms such as isosurfacing will work. The requirements of the isosurfacing algorithm are enumerated and related to the places where the partial derivatives of the polynomial become zero. The original isosurfacing algorithm is then applied to each of these regions in turn.

  5. Nonlinearity, structure, and the role of higher order statistics: What kind of universality can be expected in MHD and plasma turbulence? (Invited)

    NASA Astrophysics Data System (ADS)

    Matthaeus, W. H.; Wan, M.; Osman, K.; Servidio, S.; Oughton, S.; Dmitruk, P.; Greco, A.

    2010-12-01

    “Universality” in hydrodynamic turbulence usually refers to the existence of unique statistical distributions that are obtained as the Reynolds number tends to infinity. In such cases the hierarchy of structure functions would approach particular functional forms, implying for example a standard form of the energy spectrum. Magnetohydrodynamics (MHD) is more complex for several reasons. First, there are several spectral fluxes and several types of cascades, including inverse and direct cascades. Second, there are several additional dimensionless parameters, including the ratio of magnetic Reynolds number to Reynolds number, the ratio of kinetic to magnetic energy, and when cross helicity is nonzero, the ratio of two fundamental lengths scales - one for each Elsasser field. For these reasons it is doubtful that there are universal MHD turbulence statistics, in the usual sense. Recent simulation work supports this conclusion, as very similar initial energy spectra can lead to very different time evolution depending on details of initial conditions. We suggest here another approach to finding unifying principles for MHD turbulence. We begin with discussion of spontaneous generation of distinctive local correlations, including those corresponding to Beltrami, Alfvenic and force-free states. An argument is outlined as to how these correlations require certain higher order correlations to be generated. In real space these correspond to generation of region of reduced nonlinearity. Spatial patches of correlation may be separated by quasi-discontinuous jumps in the local parameters. This gives rise, e.g., to frequent appearance of “tangential discontinuities” due to formation of current sheets (and the possibility of reconnection) between adjacent quasi-relaxed flux tubes. Recent evidence supports the view that (1) the generation of high wavenumber nonGaussian statistics is a signature of these local rapid relaxation processes, (2) distinctive correlations form in

  6. HOTCFGM-2D: A Coupled Higher-Order Theory for Cylindrical Structural Components with Bi-Directionally Components with Bi-Directionally Graded Microstructures

    NASA Technical Reports Server (NTRS)

    Pindera, Marek-Jerzy; Aboudi, Jacob

    2000-01-01

    The objective of this two-year project was to develop and deliver to the NASA-Glenn Research Center a two-dimensional higher-order theory, and related computer codes, for the analysis and design of cylindrical functionally graded materials/structural components for use in advanced aircraft engines (e.g., combustor linings, rotor disks, heat shields, brisk blades). To satisfy this objective, two-dimensional version of the higher-order theory, HOTCFGM-2D, and four computer codes based on this theory, for the analysis and design of structural components functionally graded in the radial and circumferential directions were developed in the cylindrical coordinate system r-Theta-z. This version of the higher-order theory is a significant generalization of the one-dimensional theory, HOTCFGM-1D, developed during the FY97 for the analysis and design of cylindrical structural components with radially graded microstructures. The generalized theory is applicable to thin multi-phased composite shells/cylinders subjected to steady-state thermomechanical, transient thermal and inertial loading applied uniformly along the axial direction such that the overall deformation is characterized by a constant average axial strain. The reinforcement phases are uniformly distributed in the axial direction, and arbitrarily distributed in the radial and circumferential direction, thereby allowing functional grading of the internal reinforcement in the r-Theta plane. The four computer codes fgmc3dq.cylindrical.f, fgmp3dq.cylindrical.f, fgmgvips3dq.cylindrical.f, and fgmc3dq.cylindrical.transient.f are research-oriented codes for investigating the effect of functionally graded architectures, as well as the properties of the multi-phase reinforcement, in thin shells subjected to thermomechanical and inertial loading, on the internal temperature, stress and (inelastic) strain fields. The reinforcement distribution in the radial and circumferential directions is specified by the user. The thermal

  7. Representing higher-order dependencies in networks

    PubMed Central

    Xu, Jian; Wickramarathne, Thanuka L.; Chawla, Nitesh V.

    2016-01-01

    To ensure the correctness of network analysis methods, the network (as the input) has to be a sufficiently accurate representation of the underlying data. However, when representing sequential data from complex systems, such as global shipping traffic or Web clickstream traffic as networks, conventional network representations that implicitly assume the Markov property (first-order dependency) can quickly become limiting. This assumption holds that, when movements are simulated on the network, the next movement depends only on the current node, discounting the fact that the movement may depend on several previous steps. However, we show that data derived from many complex systems can show up to fifth-order dependencies. In these cases, the oversimplifying assumption of the first-order network representation can lead to inaccurate network analysis results. To address this problem, we propose the higher-order network (HON) representation that can discover and embed variable orders of dependencies in a network representation. Through a comprehensive empirical evaluation and analysis, we establish several desirable characteristics of HON, including accuracy, scalability, and direct compatibility with the existing suite of network analysis methods. We illustrate how HON can be applied to a broad variety of tasks, such as random walking, clustering, and ranking, and we demonstrate that, by using it as input, HON yields more accurate results without any modification to these tasks. PMID:27386539

  8. Quantifying higher-order correlations in a neuronal pool

    NASA Astrophysics Data System (ADS)

    Montangie, Lisandro; Montani, Fernando

    2015-03-01

    Recent experiments involving a relatively large population of neurons have shown a very significant amount of higher-order correlations. However, little is known of how these affect the integration and firing behavior of a population of neurons beyond the second order statistics. To investigate how higher-order inputs statistics can shape beyond pairwise spike correlations and affect information coding in the brain, we consider a neuronal pool where each neuron fires stochastically. We develop a simple mathematically tractable model that makes it feasible to account for higher-order spike correlations in a neuronal pool with highly interconnected common inputs beyond second order statistics. In our model, correlations between neurons appear from q-Gaussian inputs into threshold neurons. The approach constitutes the natural extension of the Dichotomized Gaussian model, where the inputs to the model are just Gaussian distributed and therefore have no input interactions beyond second order. We obtain an exact analytical expression for the joint distribution of firing, quantifying the degree of higher-order spike correlations, truly emphasizing the functional aspects of higher-order statistics, as we account for beyond second order inputs correlations seen by each neuron within the pool. We determine how higher-order correlations depend on the interaction structure of the input, showing that the joint distribution of firing is skewed as the parameter q increases inducing larger excursions of synchronized spikes. We show how input nonlinearities can shape higher-order correlations and enhance coding performance by neural populations.

  9. A Novel Higher Order Artificial Neural Networks

    NASA Astrophysics Data System (ADS)

    Xu, Shuxiang

    2010-05-01

    In this paper a new Higher Order Neural Network (HONN) model is introduced and applied in several data mining tasks. Data Mining extracts hidden patterns and valuable information from large databases. A hyperbolic tangent function is used as the neuron activation function for the new HONN model. Experiments are conducted to demonstrate the advantages and disadvantages of the new HONN model, when compared with several conventional Artificial Neural Network (ANN) models: Feedforward ANN with the sigmoid activation function; Feedforward ANN with the hyperbolic tangent activation function; and Radial Basis Function (RBF) ANN with the Gaussian activation function. The experimental results seem to suggest that the new HONN holds higher generalization capability as well as abilities in handling missing data.

  10. Finesky -- removing higher order sky residuals

    NASA Astrophysics Data System (ADS)

    Dahlen, Tomas; Grumm, David

    2010-07-01

    We report on a new IRAF task called finesky that removes higher order sky residuals in NICMOS images by creating a masked median image of the observed sky. This median sky image is thereafter subtracted from the science images. A residual signal after image processing using the calibration software calnica may be present due to reference files that do not sufficiently match the conditions of the observations. This includes a slight mismatch in the dark current or the flat-field corrections. The task described here can also used to create sky flat-field images.

  11. Higher-order brane gravity models

    SciTech Connect

    Dabrowski, Mariusz P.; Balcerzak, Adam

    2010-06-23

    We discuss a very general theory of gravity, of which Lagrangian is an arbitrary function of the curvature invariants, on the brane. In general, the formulation of the junction conditions (except for Euler characteristics such as Gauss-Bonnet term) leads to the powers of the delta function and requires regularization. We suggest the way to avoid such a problem by imposing the metric and its first derivative to be regular at the brane, the second derivative to have a kink, the third derivative of the metric to have a step function discontinuity, and no sooner as the fourth derivative of the metric to give the delta function contribution to the field equations. Alternatively, we discuss the reduction of the fourth-order gravity to the second order theory by introducing extra scalar and tensor fields: the scalaron and the tensoron. In order to obtain junction conditions we apply two methods: the application of the Gauss-Codazzi formalism and the application of the generalized Gibbons-Hawking boundary terms which are appended to the appropriate actions. In the most general case we derive junction conditions without assuming the continuity of the scalaron and the tensoron on the brane. The derived junction conditions can serve studying the cosmological implications of the higher-order brane gravity models.

  12. On higher structures

    NASA Astrophysics Data System (ADS)

    Baas, Nils A.

    2016-08-01

    In this paper, we discuss various philosophical aspects of the hyperstructure concept extending networks and higher categories. By this discussion, we hope to pave the way for applications and further developments of the mathematical theory of hyperstructures.

  13. Theorem Proving In Higher Order Logics

    NASA Technical Reports Server (NTRS)

    Carreno, Victor A. (Editor); Munoz, Cesar A.; Tahar, Sofiene

    2002-01-01

    The TPHOLs International Conference serves as a venue for the presentation of work in theorem proving in higher-order logics and related areas in deduction, formal specification, software and hardware verification, and other applications. Fourteen papers were submitted to Track B (Work in Progress), which are included in this volume. Authors of Track B papers gave short introductory talks that were followed by an open poster session. The FCM 2002 Workshop aimed to bring together researchers working on the formalisation of continuous mathematics in theorem proving systems with those needing such libraries for their applications. Many of the major higher order theorem proving systems now have a formalisation of the real numbers and various levels of real analysis support. This work is of interest in a number of application areas, such as formal methods development for hardware and software application and computer supported mathematics. The FCM 2002 consisted of three papers, presented by their authors at the workshop venue, and one invited talk.

  14. Higher Order Macro Coefficients in Periodic Homogenization

    NASA Astrophysics Data System (ADS)

    Conca, Carlos; San Martin, Jorge; Smaranda, Loredana; Vanninathan, Muthusamy

    2011-09-01

    A first set of macro coefficients known as the homogenized coefficients appear in the homogenization of PDE on periodic structures. If energy is increased or scale is decreased, these coefficients do not provide adequate approximation. Using Bloch decomposition, it is first realized that the above coefficients correspond to the lowest energy and the largest scale. This naturally paves the way to introduce other sets of macro coefficients corresponding to higher energies and lower scales which yield better approximation. The next task is to compare their properties with those of the homogenized coefficients. This article reviews these developments along with some new results yet to be published.

  15. Organization into Higher Ordered Ring Structures Counteracts Membrane Binding of IM30, a Protein Associated with Inner Membranes in Chloroplasts and Cyanobacteria.

    PubMed

    Heidrich, Jennifer; Wulf, Verena; Hennig, Raoul; Saur, Michael; Markl, Jürgen; Sönnichsen, Carsten; Schneider, Dirk

    2016-07-15

    The IM30 (inner membrane-associated protein of 30 kDa), also known as the Vipp1 (vesicle-inducing protein in plastids 1), has a crucial role in thylakoid membrane biogenesis and maintenance. Recent results suggest that the protein binds peripherally to membranes containing negatively charged lipids. However, although IM30 monomers interact and assemble into large oligomeric ring complexes with different numbers of monomers, it is still an open question whether ring formation is crucial for membrane interaction. Here we show that binding of IM30 rings to negatively charged phosphatidylglycerol membrane surfaces results in a higher ordered membrane state, both in the head group and in the inner core region of the lipid bilayer. Furthermore, by using gold nanorods covered with phosphatidylglycerol layers and single particle spectroscopy, we show that not only IM30 rings but also lower oligomeric IM30 structures interact with membranes, although with higher affinity. Thus, ring formation is not crucial for, and even counteracts, membrane interaction of IM30. PMID:27226585

  16. Feynman rules of higher-order poles in CHY construction

    NASA Astrophysics Data System (ADS)

    Huang, Rijun; Feng, Bo; Luo, Ming-xing; Zhu, Chuan-Jie

    2016-06-01

    In this paper, we generalize the integration rules for scattering equations to situations where higher-order poles are present. We describe the strategy to deduce the Feynman rules of higher-order poles from known analytic results of simple CHY-integrands, and propose the Feynman rules for single double pole and triple pole as well as duplex-double pole and triplex-double pole structures. We demonstrate the validation and strength of these rules by ample non-trivial examples.

  17. Higher-order Genome Organization in Human Disease

    PubMed Central

    Misteli, Tom

    2010-01-01

    Genomes are organized into complex higher-order structures by folding of the DNA into chromatin fibers, chromosome domains, and ultimately chromosomes. The higher-order organization of genomes is functionally important for gene regulation and control of gene expression programs. Defects in how chromatin is globally organized are relevant for physiological and pathological processes. Mutations and transcriptional misregulation of several global genome organizers are linked to human diseases and global alterations in chromatin structure are emerging as key players in maintenance of genome stability, aging, and the formation of cancer translocations. PMID:20591991

  18. Higher-Order Abilities Conceptualized within Guilford's Structure-of-Intellect (SOI) Model for a Sample of United States Coast Guard Academy Cadets: A Reanalysis of an SOI Data Base.

    ERIC Educational Resources Information Center

    Chen, Chin-Yi; Michael, William B.

    1993-01-01

    Empirical validation of the first-order and higher-order factor structures of the structure-of-intellect (SOI) model was provided by reanalysis of a database of 39 measures administered to 178 Coast Guard Cadets. Results suggest that SOI could be reconceptualized as a pyramid-like hierarchical theory of intelligence. (SLD)

  19. Applications of circular dichroism (CD) for structural analysis of proteins: qualification of near- and far-UV CD for protein higher order structural analysis.

    PubMed

    Li, Cynthia H; Nguyen, Xichdao; Narhi, Linda; Chemmalil, Letha; Towers, Edward; Muzammil, Salman; Gabrielson, John; Jiang, Yijia

    2011-11-01

    Circular dichroism (CD) spectroscopy is routinely used in the biopharmaceutical industry to study the effects of manufacturing, formulation, and storage conditions on protein conformation and stability, and these results are often included in regulatory filings. In this context, the purpose of CD spectroscopy is often to verify that a change in the formulation or manufacturing process of a product has not produced a change in the conformation of a protein. A comparison of two or more spectra is often required to confirm that the protein's structure has been maintained. Traditionally, such comparisons have been qualitative in nature, based on visually inspecting the overlaid spectra. However, visual assessment is inherently subjective and therefore prone to error. Furthermore, recent requests from regulatory agencies to demonstrate the suitability of the CD spectroscopic method for the purpose of comparing spectra have highlighted the need to appropriately qualify CD spectroscopy for characterization of biopharmaceutical protein products. In this study, we use a numerical spectral comparison approach to establish the precision of the CD spectroscopic method and to demonstrate that it is suitable for protein structural characterization in numerous biopharmaceutical applications. PMID:21732370

  20. Higher Education Guidelines for Executive Order 11246.

    ERIC Educational Resources Information Center

    Office for Civil Rights (DHEW), Washington, DC.

    This document presents and explains Executive Order 11246, the order prohibiting discrimination under federal contracts in colleges and universities. Part one of the document describes the legal provisions of the order; part two deals with personnel policies and practices including recruitment, hiring, anti-nepotism policies, training, promotion,…

  1. Symplectic representation of higher-order guiding-center theory

    NASA Astrophysics Data System (ADS)

    Brizard, Alain; Tronko, Natalia

    2012-03-01

    Two representations of guiding-center theory are possible depending on whether the guiding-center Poisson bracket (i.e., the symplectic structure) or the Hamiltonian contains higher-order corrections due to the nonuniformity of the magnetic field. By combining the guiding-center parallel hierarchy with the symplectic representation, the guiding-center equations of motion are derived with second-order corrections included in the symplectic structure without the need of carrying out the guiding-center transformation to second order. Guiding-center polarization and magnetization are thus shown to arise naturally from higher-order guiding-center theory within the context of a two-step derivation of nonlinear gyrokinetic theory.footnotetextA. J. Brizard and T. S. Hahm, Rev. Mod. Phys. 79, 421 (2007).

  2. Hydrogen peroxide mediates higher order chromatin degradation.

    PubMed

    Bai, H; Konat, G W

    2003-01-01

    Although a large body of evidence supports a causative link between oxidative stress and neurodegeneration, the mechanisms are still elusive. We have recently demonstrated that hydrogen peroxide (H(2)O(2)), the major mediator of oxidative stress triggers higher order chromatin degradation (HOCD), i.e. excision of chromatin loops at the matrix attachment regions (MARs). The present study was designed to determine the specificity of H(2)O(2) in respect to HOCD induction. Rat glioma C6 cells were exposed to H(2)O(2) and other oxidants, and the fragmentation of genomic DNA was assessed by field inversion gel electrophoresis (FIGE). S1 digestion before FIGE was used to detect single strand fragmentation. The exposure of C6 cells to H(2)O(2) induced a rapid and extensive HOCD. Thus, within 30 min, total chromatin was single strandedly digested into 50 kb fragments. Evident HOCD was elicited by H(2)O(2) at concentrations as low as 5 micro M. HOCD was mostly reversible during 4-8h following the removal of H(2)O(2) from the medium indicating an efficient relegation of the chromatin fragments. No HOCD was induced by H(2)O(2) in isolated nuclei indicating that HOCD-endonuclease is activated indirectly by cytoplasmic signal pathways triggered by H(2)O(2). The exposure of cells to a synthetic peroxide, i.e. tert-butyrylhydroperoxide (tBH) also induced HOCD, but to a lesser extent than H(2)O(2). Contrary to the peroxides, the exposure of cells to equitoxic concentration of hypochlorite and spermine NONOate, a nitric oxide generator, failed to induce rapid HOCD. These results indicate that rapid HOCD is not a result of oxidative stress per se, but is rather triggered by signaling cascades initiated specifically by H(2)O(2). Furthermore, the rapid and extensive HOCD was observed in several rat and human cell lines challenged with H(2)O(2), indicating that the process is not restricted to glial cells, but rather represents a general response of cells to H(2)O(2). PMID:12421592

  3. A model of photon cell killing based on the spatio-temporal clustering of DNA damage in higher order chromatin structures.

    PubMed

    Herr, Lisa; Friedrich, Thomas; Durante, Marco; Scholz, Michael

    2014-01-01

    We present a new approach to model dose rate effects on cell killing after photon radiation based on the spatio-temporal clustering of DNA double strand breaks (DSBs) within higher order chromatin structures of approximately 1-2 Mbp size, so called giant loops. The main concept of this approach consists of a distinction of two classes of lesions, isolated and clustered DSBs, characterized by the number of double strand breaks induced in a giant loop. We assume a low lethality and fast component of repair for isolated DSBs and a high lethality and slow component of repair for clustered DSBs. With appropriate rates, the temporal transition between the different lesion classes is expressed in terms of five differential equations. These allow formulating the dynamics involved in the competition of damage induction and repair for arbitrary dose rates and fractionation schemes. Final cell survival probabilities are computable with a cell line specific set of three parameters: The lethality for isolated DSBs, the lethality for clustered DSBs and the half-life time of isolated DSBs. By comparison with larger sets of published experimental data it is demonstrated that the model describes the cell line dependent response to treatments using either continuous irradiation at a constant dose rate or to split dose irradiation well. Furthermore, an analytic investigation of the formulation concerning single fraction treatments with constant dose rates in the limiting cases of extremely high or low dose rates is presented. The approach is consistent with the Linear-Quadratic model extended by the Lea-Catcheside factor up to the second moment in dose. Finally, it is shown that the model correctly predicts empirical findings about the dose rate dependence of incidence probabilities for deterministic radiation effects like pneumonitis and the bone marrow syndrome. These findings further support the general concepts on which the approach is based. PMID:24392100

  4. Higher-Order Item Response Models for Hierarchical Latent Traits

    ERIC Educational Resources Information Center

    Huang, Hung-Yu; Wang, Wen-Chung; Chen, Po-Hsi; Su, Chi-Ming

    2013-01-01

    Many latent traits in the human sciences have a hierarchical structure. This study aimed to develop a new class of higher order item response theory models for hierarchical latent traits that are flexible in accommodating both dichotomous and polytomous items, to estimate both item and person parameters jointly, to allow users to specify…

  5. Fostering Higher-Order Thinking in Science Class: Teachers' Reflections

    ERIC Educational Resources Information Center

    Barak, Moshe; Shakhman, Larisa

    2008-01-01

    The study reported in this article aimed at exploring what teachers know and do about fostering higher-order thinking skills in teaching science, and how they see themselves involved in achieving this end. Data were collected through semi-structured interviews with 11 teachers experienced in teaching high school physics, which is considered a…

  6. On the higher orders of hyperspherical harmonics

    NASA Astrophysics Data System (ADS)

    Arribas, E.; Navarro, J.; Fabre de la Ripelle, M.

    1983-08-01

    We suggest a procedure to evaluate matrix elements between hyperspherical harmonics of any order. The method is based on the hyperspherical expansion of a Slater determinant constructed with oscillator wavefunctions. Explicit formulas are given for all matrix elements up to order Lm+2.

  7. Higher-order corrections in threshold resummation

    NASA Astrophysics Data System (ADS)

    Moch, S.; Vermaseren, J. A. M.; Vogt, A.

    2005-10-01

    We extend the threshold resummation exponents G in Mellin- N space to the fourth logarithmic (N 3LL) order collecting the terms αs2( to all orders in the strong coupling constant α. Comparing the results to our previous three-loop calculations for deep-inelastic scattering (DIS), we derive the universal coefficients B and B governing the final-state jet functions to order αs3, extending the previous quark and gluon results by one and two orders. A curious relation is found at second order between these quantities, the splitting functions and the large-angle soft emissions in Drell-Yan type processes. We study the numerical effect of the N 3LL corrections using both the fully exponentiated form and the expansion of the coefficient function in towers of logarithms.

  8. Constructing higher-order hydrodynamics: The third order

    NASA Astrophysics Data System (ADS)

    Grozdanov, Sašo; Kaplis, Nikolaos

    2016-03-01

    Hydrodynamics can be formulated as the gradient expansion of conserved currents in terms of the fundamental fields describing the near-equilibrium fluid flow. In the relativistic case, the Navier-Stokes equations follow from the conservation of the stress-energy tensor to first order in derivatives. In this paper, we go beyond the presently understood second-order hydrodynamics and discuss the systematization of obtaining the hydrodynamic expansion to an arbitrarily high order. As an example of the algorithm that we present, we fully classify the gradient expansion at third order for neutral fluids in four dimensions, thus finding the most general next-to-leading-order corrections to the relativistic Navier-Stokes equations in curved space-time. In doing so, we list 20 new transport coefficient candidates in the conformal case and 68 in the nonconformal case. As we do not consider any constraints that could potentially arise from the local entropy current analysis, this is the maximal possible set of neutral third-order transport coefficients. To investigate the physical implications of these new transport coefficients, we obtain the third-order corrections to the linear dispersion relations that describe the propagation of diffusion and sound waves in relativistic fluids. We also compute the corrections to the scalar (spin-2) two-point correlation function of the third-order stress-energy tensor. Furthermore, as an example of a nonlinear hydrodynamic flow, we calculate the third-order corrections to the energy density of a boost-invariant Bjorken flow. Finally, we apply our field theoretic results to the N =4 supersymmetric Yang-Mills fluid at infinite 't Hooft coupling and an infinite number of colors to find the values of five new linear combinations of the conformal transport coefficients.

  9. Modeling Higher-Order Correlations within Cortical Microcolumns

    PubMed Central

    Köster, Urs; Sohl-Dickstein, Jascha; Gray, Charles M.; Olshausen, Bruno A.

    2014-01-01

    We statistically characterize the population spiking activity obtained from simultaneous recordings of neurons across all layers of a cortical microcolumn. Three types of models are compared: an Ising model which captures pairwise correlations between units, a Restricted Boltzmann Machine (RBM) which allows for modeling of higher-order correlations, and a semi-Restricted Boltzmann Machine which is a combination of Ising and RBM models. Model parameters were estimated in a fast and efficient manner using minimum probability flow, and log likelihoods were compared using annealed importance sampling. The higher-order models reveal localized activity patterns which reflect the laminar organization of neurons within a cortical column. The higher-order models also outperformed the Ising model in log-likelihood: On populations of 20 cells, the RBM had 10% higher log-likelihood (relative to an independent model) than a pairwise model, increasing to 45% gain in a larger network with 100 spatiotemporal elements, consisting of 10 neurons over 10 time steps. We further removed the need to model stimulus-induced correlations by incorporating a peri-stimulus time histogram term, in which case the higher order models continued to perform best. These results demonstrate the importance of higher-order interactions to describe the structure of correlated activity in cortical networks. Boltzmann Machines with hidden units provide a succinct and effective way to capture these dependencies without increasing the difficulty of model estimation and evaluation. PMID:24991969

  10. HIGHER ORDER HARD EDGE END FIELD EFFECTS.

    SciTech Connect

    BERG,J.S.

    2004-09-14

    In most cases, nonlinearities from magnets must be properly included in tracking and analysis to properly compute quantities of interest, in particular chromatic properties and dynamic aperture. One source of nonlinearities in magnets that is often important and cannot be avoided is the nonlinearity arising at the end of a magnet due to the longitudinal variation of the field at the end of the magnet. Part of this effect is independent of the longitudinal of the end. It is lowest order in the body field of the magnet, and is the result of taking a limit as the length over which the field at the end varies approaches zero. This is referred to as a ''hard edge'' end field. This effect has been computed previously to lowest order in the transverse variables. This paper describes a method to compute this effect to arbitrary order in the transverse variables, under certain constraints.

  11. Discrimination of higher-order textures.

    PubMed

    Nothdurft, H C

    1985-01-01

    Arrays of figural elements differing in certain features ('textons') may be visually segregated to yield the impression of a global figure of different texture. This fact was used to construct texture patterns of a higher level of complexity. In microstructure, these patterns reveal regular arrays of distinguishable figural elements, the segregation of which can be predicted from previous studies of human texture sensitivity. In macrostructure, clusters of such elements form new figural elements which, when repeated over space, themselves give the impression of texture at a perceptually higher level. Discrimination of such macrostructure textures was found to place similar restrictions on the form of figural elements as those of texture discrimination at the microstructure level. PMID:3836385

  12. Higher order diffractions from a circular disk

    NASA Technical Reports Server (NTRS)

    Marsland, Diane P.; Balanis, Constantine A.; Brumley, Stephen A.

    1987-01-01

    The backscattering from a circular disk is analyzed using the geometrical theory of diffraction. First-, second-, and third-order diffractions are included in the hard polarization analysis, while first-, second-, and third-order slope diffractions are included for soft polarization. Improvements in the prediction of the monostatic radar cross section over previous works are noted. For hard polarization, an excellent agreement is exhibited between experimental and theoretical results, while a very good agreement is noted for soft polarization. To further improve the soft polarization results for wide angles, a model for the creeping wave or circulating current on the edge of the disk is obtained and used to find an additional component of the backscattered field. The addition of this component significantly improves the results for wide angles, leading to excellent agreement for soft polarization also. An axial-caustic correction method using equivalent currents is also included in the analysis.

  13. Invariant Higher-Order Variational Problems II

    NASA Astrophysics Data System (ADS)

    Gay-Balmaz, François; Holm, Darryl D.; Meier, David M.; Ratiu, Tudor S.; Vialard, François-Xavier

    2012-08-01

    Motivated by applications in computational anatomy, we consider a second-order problem in the calculus of variations on object manifolds that are acted upon by Lie groups of smooth invertible transformations. This problem leads to solution curves known as Riemannian cubics on object manifolds that are endowed with normal metrics. The prime examples of such object manifolds are the symmetric spaces. We characterize the class of cubics on object manifolds that can be lifted horizontally to cubics on the group of transformations. Conversely, we show that certain types of non-horizontal geodesic on the group of transformations project to cubics. Finally, we apply second-order Lagrange-Poincaré reduction to the problem of Riemannian cubics on the group of transformations. This leads to a reduced form of the equations that reveals the obstruction for the projection of a cubic on a transformation group to again be a cubic on its object manifold.

  14. LOCAL ANISOTROPY, HIGHER ORDER STATISTICS, AND TURBULENCE SPECTRA

    SciTech Connect

    Matthaeus, W. H.; Wan, M.; Osman, K. T.; Servidio, S.; Carbone, V.; Dmitruk, P.; Oughton, S.

    2012-05-10

    Correlation anisotropy emerges dynamically in magnetohydrodynamics (MHD), producing stronger gradients across the large-scale mean magnetic field than along it. This occurs both globally and locally, and has significant implications in space and astrophysical plasmas, including particle scattering and transport, and theories of turbulence. Properties of local correlation anisotropy are further documented here by showing through numerical experiments that the effect is intensified in more localized estimates of the mean field. The mathematical formulation of this property shows that local anisotropy mixes second-order with higher order correlations. Sensitivity of local statistical estimates to higher order correlations can be understood in connection with the stochastic coordinate system inherent in such formulations. We demonstrate this in specific cases, and illustrate the connection to higher order statistics by showing the sensitivity of local anisotropy to phase randomization, after which the global measure of anisotropy is recovered at all scales of averaging. This establishes that anisotropy of the local structure function is not a measure of anisotropy of the energy spectrum. Evidently, the local enhancement of correlation anisotropy is of substantial fundamental interest and must be understood in terms of higher order correlations, specifically fourth-order and above.

  15. Higher-order terms in mode conversion

    NASA Astrophysics Data System (ADS)

    Swanson, D. G.

    1998-07-01

    The development of model equations to describe mode conversion and tunneling in an inhomogeneous plasma usually uses expansions of the Modified Bessel functions in the parameter λ=1/2k⊥2ρL2, keeping only the lowest possible order to demonstrate tunneling. With the high temperatures of fusion parameters, especially for fusion alpha particles, this parameter may not be small. It is shown here that the effective expansion parameter is really βj=2μ0njkTj/B02, the ratio of plasma pressure to the magnetic pressure.

  16. Systems with Higher-Order Modulation

    NASA Astrophysics Data System (ADS)

    Seimetz, Matthias

    With the objective of reducing costs per information bit in optical communication networks, per fibre capacities and optical transparent transmission lengths have been stepped up by the introduction of new technology in recent years. The innovation of the erbium-doped fibre amplifier (EDFA) at the beginning of the nineties facilitated long distances to be bridged without electro-optical conversion. Wavelength division multiplexing (WDM) technology allowed a lot of wavelength channels to be simultaneously transmitted over one fibre and to be amplified by one EDFA with high bandwidth, offering a huge network capacity. At this time, the modulation format of choice was the simple "on-off keying" (OOK), and there was no need for increasing spectral efficiency. The internet traffic growth during the nineties required increasing transmission rates. In that context, the transmission impairments of the optical fibre had to be counteracted and the application of differential binary phased shift keying (DBPSK) became an issue, providing for a higher robustness against nonlinear effects [1]. Moreover, the transmission behaviour of binary intensity modulation was optimized by using alternative optical pulse shapes such as return to zero (RZ) and by employing schemes with auxiliary phase coding, such as optical duobinary, which exhibits a higher tolerance against chromatic dispersion (CD). The capacity-distance product was further enhanced by applying optical dispersion compensation, Raman amplification and advanced optical fibres, as well as through electronic means, such as forward error correction (FEC) and the adaptive compensation of CD and polarization mode dispersion (PMD).

  17. Evaluation of expressions involving higher order derivations

    NASA Technical Reports Server (NTRS)

    Grossman, Robert

    1990-01-01

    The local geometric properties of a nonlinear control system defined by vector fields E(sub 1),..., E(sub M) are determined by the algebraic properties of the iterated Lie brackets of the E(sub j)'s. The problem of rewriting expressions is examined involving the E(sub j)'s in terms of the D(sub mu)'s in such a way as to handle effectively any cancellation occurring due to commuting of the D(sub mu)'s. A data structure is introduced which allows us to organize the computation to take advantage of the symmetries in the expression and reduce the operation count.

  18. Higher Order Chromaticity Correction for ELIC

    NASA Astrophysics Data System (ADS)

    Sayed, Hisham; Bogacz, Alex

    2010-02-01

    The proposed electron collider lattice design with extremely low betas at the interaction Point IP (β*˜ 0.5cm) and the precedently large longitudinal acceptance of the collider ring (δp/p = 0.005) [1], makes the chromatic corrections of paramount importance. Here the chromatic effects of the final focus quadruples are corrected with two families of sextuples in a dispersive region; one family per plane. Each family consists of two pairs of sextuples located symmetrically around the interaction point IP. A confined dispersion wave around the IP is generated by two bending magnets (one at each side of the IP with mirror reflected Polarities) which also develop the vertical staking design. The resulting spherical aberrations induced by the sextuples are mitigated by design; the matching section optics features an inverse identity transformation between sextuples in each pair. A dedicated optics is placed in the matching region to implement sextuple orthogonality in both planes, which in turns minimizes the required sextuple strength and eventually leads to larger dynamic aperture of the collider. The betatron phase advances from the IP to the sextuples are chosen to eliminate the second order chromatic aberration. )

  19. Higher order intercommutations in cosmic string collisions.

    PubMed

    Achúcarro, A; Verbiest, G J

    2010-07-01

    We report the first observation of multiple intercommutation (more than two successive reconnections) of Abelian Higgs cosmic strings at ultrahigh collision speeds, and the formation of "kink trains" with up to four closely spaced left- or right-moving kinks, in the deep type-II regime 16 ≤ β ≤ 64 (where β=m(scalar)2/m(gauge)2). The minimum critical speed for double reconnection goes down from ∼0.98c at β = 1 to ∼0.86c for β = 64. The process leading to the second intercommutation changes with β: it involves an expanding loop if β ≥ 16, but only a radiation blob if 1 < β ≤ 8. Triple reconnections are generic in the loop-mediated regime for collision parameters on the boundary between single and double reconnection. For β = 16 we observe quadruple events. We comment on the effect of strongly repulsive core interactions on the small scale structure on the strings and their gravitational wave emission. PMID:20867697

  20. Higher Order Intercommutations in Cosmic String Collisions

    SciTech Connect

    Achucarro, A.; Verbiest, G. J.

    2010-07-09

    We report the first observation of multiple intercommutation (more than two successive reconnections) of Abelian Higgs cosmic strings at ultrahigh collision speeds, and the formation of ''kink trains'' with up to four closely spaced left- or right-moving kinks, in the deep type-II regime 16{<=}{beta}{<=}64 (where {beta}=m{sub scalar}{sup 2}/m{sub gauge}{sup 2}). The minimum critical speed for double reconnection goes down from {approx}0.98c at {beta}=1 to {approx}0.86c for {beta}=64. The process leading to the second intercommutation changes with {beta}: it involves an expanding loop if {beta}{>=}16, but only a radiation blob if 1<{beta}{<=}8. Triple reconnections are generic in the loop-mediated regime for collision parameters on the boundary between single and double reconnection. For {beta}=16 we observe quadruple events. We comment on the effect of strongly repulsive core interactions on the small scale structure on the strings and their gravitational wave emission.

  1. Higher-order polarization singularitites in tailored vector beams

    NASA Astrophysics Data System (ADS)

    Otte, E.; Alpmann, C.; Denz, C.

    2016-07-01

    Higher-order polarization singularities embedded in tailored vector beams are introduced and experimentally realized. As holographic modulation allows to define order and location of any vectorial singularity, the surrounding vector field can be dynamically shaped. We demonstrate light fields associated with flowers or spider webs due to regular and even irregular patterns of the orientation of polarization ellipses. Beyond that, not yet investigated hybrid structures are introduced that allow generating networks of flowers and webs in very close vicinity. Our results pave the way to applications of singular optics in spatially extended, optimized optical tweezing and high-resolution imaging.

  2. Structural order in glassy water.

    PubMed

    Giovambattista, Nicolas; Debenedetti, Pablo G; Sciortino, Francesco; Stanley, H Eugene

    2005-06-01

    We investigate structural order in glassy water by performing classical molecular dynamics simulations using the extended simple point charge (SPC/E) model of water. We perform isochoric cooling simulations across the glass transition temperature at different cooling rates and densities. We quantify structural order by orientational and translational order metrics. Upon cooling the liquid into the glassy state, both the orientational order parameter Q and translational order parameter tau increase. At T=0 K, the glasses fall on a line in the Q-tau plane or order map. The position of this line depends only on density and coincides with the location in the order map of the inherent structures (IS) sampled upon cooling. We evaluate the energy of the IS, eIS(T), and find that both order parameters for the IS are proportional to eIS. We also study the structural order during the transformation of low-density amorphous ice (LDA) to high-density amorphous ice (HDA) upon isothermal compression and are able to identify distinct regions in the order map corresponding to these glasses. Comparison of the order parameters for LDA and HDA with those obtained upon isochoric cooling indicates major structural differences between glasses obtained by cooling and glasses obtained by compression. These structural differences are only weakly reflected in the pair correlation function. We also characterize the evolution of structural order upon isobaric annealing, leading at high pressure to very-high density amorphous ice (VHDA). PMID:16089741

  3. Conceptualizing and Assessing Higher-Order Thinking in Reading

    ERIC Educational Resources Information Center

    Afflerbach, Peter; Cho, Byeong-Young; Kim, Jong-Yun

    2015-01-01

    Students engage in higher-order thinking as they read complex texts and perform complex reading-related tasks. However, the most consequential assessments, high-stakes tests, are currently limited in providing information about students' higher-order thinking. In this article, we describe higher-order thinking in relation to reading. We provide a…

  4. Skinner-Rusk unified formalism for higher-order systems

    NASA Astrophysics Data System (ADS)

    Prieto-Martínez, Pedro Daniel; Román-Roy, Narciso

    2012-07-01

    The Lagrangian-Hamiltonian unified formalism of R. Skinner and R. Rusk was originally stated for autonomous dynamical systems in classical mechanics. It has been generalized for non-autonomous first-order mechanical systems, first-order and higher-order field theories, and higher-order autonomous systems. In this work we present a generalization of this formalism for higher-order non-autonomous mechanical systems.

  5. The Meaning of Higher-Order Factors in Reflective-Measurement Models

    ERIC Educational Resources Information Center

    Eid, Michael; Koch, Tobias

    2014-01-01

    Higher-order factor analysis is a widely used approach for analyzing the structure of a multidimensional test. Whenever first-order factors are correlated researchers are tempted to apply a higher-order factor model. But is this reasonable? What do the higher-order factors measure? What is their meaning? Willoughby, Holochwost, Blanton, and Blair…

  6. Higher-order Dirac solitons in binary waveguide arrays

    SciTech Connect

    Tran, Truong X.; Duong, Dũng C.

    2015-10-15

    We study optical analogues of higher-order Dirac solitons (HODSs) in binary waveguide arrays. Like higher-order solitons obtained from the well-known nonlinear Schrödinger equation governing the pulse propagation in an optical fiber, these HODSs have amplitude profiles which are numerically shown to be periodic over large propagation distances. At the same time, HODSs possess some unique features. Firstly, the period of a HODS depends on its order parameter. Secondly, the discrete nature in binary waveguide arrays imposes the upper limit on the order parameter of HODSs. Thirdly, the order parameter of HODSs can vary continuously in a certain range. - Highlights: • Higher-order Dirac solitons in nonlinear binary waveguide arrays are numerically demonstrated. • Amplitude profiles of higher-order Dirac solitons are periodic during propagation. • The period of higher-order Dirac solitons decreases when the soliton order increases.

  7. Introduction to Higher Order Spatial Statistics in Cosmology

    NASA Astrophysics Data System (ADS)

    Szapudi, I.

    Higher order spatial statistics characterize non-Gaussian aspects of random fields, which are ubiquitous in cosmology: from the cosmic microwave background (CMB) to the large-scale structure (LSS) of the universe. These random fields are rich in their properties; they can be continuous or discrete; can have one through three, or even more dimensions; their degree of non- Gaussianity ranges from tiny to significant. Yet, there are several techniques and ideas, which are applicable to virtually all cosmological random fields, be it Lyman-a forests, LSS, or CMB.

  8. Higher Education's New Global Order: How and Why Governments Are Creating Structured Opportunity Markets. Research & Occasional Paper Series: CSHE.10.09

    ERIC Educational Resources Information Center

    Douglass, John Aubrey

    2009-01-01

    In the United States, developing "human capital" for both economic and social benefit is an idea as old as the nation itself and led to the emergence of world's first mass higher education system. Now most other nations are racing to expand access to universities and colleges and to expand their role in society. Higher education is growing…

  9. A Recurrence Relation Approach to Higher Order Quantum Superintegrability

    NASA Astrophysics Data System (ADS)

    Kalnins, Ernie G.; Kress, Jonathan M.; Miller, Willard

    2011-03-01

    We develop our method to prove quantum superintegrability of an integrable 2D system, based on recurrence relations obeyed by the eigenfunctions of the system with respect to separable coordinates. We show that the method provides rigorous proofs of superintegrability and explicit constructions of higher order generators for the symmetry algebra. We apply the method to 5 families of systems, each depending on a parameter k, including most notably the caged anisotropic oscillator, the Tremblay, Turbiner and Winternitz system and a deformed Kepler-Coulomb system, and we give proofs of quantum superintegrability for all rational values of k, new for 4 of these systems. In addition, we show that the explicit information supplied by the special function recurrence relations allows us to prove, for the first time in 4 cases, that the symmetry algebra generated by our lowest order symmetries closes and to determine the associated structure equations of the algebras for each k. We have no proof that our generating symmetries are of lowest possible order, but we have no counterexamples, and we are confident we can can always find any missing generators from our raising and lowering operator recurrences. We also get for free, one variable models of the action of the symmetry algebra in terms of difference operators. We describe how the Stäckel transform acts and show that it preserves the structure equations.

  10. Promoting Higher Order Thinking Skills Using Inquiry-Based Learning

    ERIC Educational Resources Information Center

    Madhuri, G. V.; Kantamreddi, V. S. S. N; Prakash Goteti, L. N. S.

    2012-01-01

    Active learning pedagogies play an important role in enhancing higher order cognitive skills among the student community. In this work, a laboratory course for first year engineering chemistry is designed and executed using an inquiry-based learning pedagogical approach. The goal of this module is to promote higher order thinking skills in…

  11. Higher-Order Theory for Functionally Graded Materials

    NASA Technical Reports Server (NTRS)

    Aboudi, Jacob; Pindera, Marek-Jerzy; Arnold, Steven M.

    1999-01-01

    This paper presents the full generalization of the Cartesian coordinate-based higher-order theory for functionally graded materials developed by the authors during the past several years. This theory circumvents the problematic use of the standard micromechanical approach, based on the concept of a representative volume element, commonly employed in the analysis of functionally graded composites by explicitly coupling the local (microstructural) and global (macrostructural) responses. The theoretical framework is based on volumetric averaging of the various field quantities, together with imposition of boundary and interfacial conditions in an average sense between the subvolumes used to characterize the composite's functionally graded microstructure. The generalization outlined herein involves extension of the theoretical framework to enable the analysis of materials characterized by spatially variable microstructures in three directions. Specialization of the generalized theoretical framework to previously published versions of the higher-order theory for materials functionally graded in one and two directions is demonstrated. In the applications part of the paper we summarize the major findings obtained with the one-directional and two-directional versions of the higher-order theory. The results illustrate both the fundamental issues related to the influence of microstructure on microscopic and macroscopic quantities governing the response of composites and the technologically important applications. A major issue addressed herein is the applicability of the classical homogenization schemes in the analysis of functionally graded materials. The technologically important applications illustrate the utility of functionally graded microstructures in tailoring the response of structural components in a variety of applications involving uniform and gradient thermomechanical loading.

  12. First and Higher Order Effects on Zero Order Radiative Transfer Model

    NASA Astrophysics Data System (ADS)

    Neelam, M.; Mohanty, B.

    2014-12-01

    Microwave radiative transfer model are valuable tool in understanding the complex land surface interactions. Past literature has largely focused on local sensitivity analysis for factor priotization and ignoring the interactions between the variables and uncertainties around them. Since land surface interactions are largely nonlinear, there always exist uncertainties, heterogeneities and interactions thus it is important to quantify them to draw accurate conclusions. In this effort, we used global sensitivity analysis to address the issues of variable uncertainty, higher order interactions, factor priotization and factor fixing for zero-order radiative transfer (ZRT) model. With the to-be-launched Soil Moisture Active Passive (SMAP) mission of NASA, it is very important to have a complete understanding of ZRT for soil moisture retrieval to direct future research and cal/val field campaigns. This is a first attempt to use GSA technique to quantify first order and higher order effects on brightness temperature from ZRT model. Our analyses reflect conditions observed during the growing agricultural season for corn and soybeans in two different regions in - Iowa, U.S.A and Winnipeg, Canada. We found that for corn fields in Iowa, there exist significant second order interactions between soil moisture, surface roughness parameters (RMS height and correlation length) and vegetation parameters (vegetation water content, structure and scattering albedo), whereas in Winnipeg, second order interactions are mainly due to soil moisture and vegetation parameters. But for soybean fields in both Iowa and Winnipeg, we found significant interactions only to exist between soil moisture and surface roughness parameters.

  13. Higher Order Mode Excitations in Gyro-amplifiers

    NASA Astrophysics Data System (ADS)

    Nguyen, Khanh

    2000-10-01

    A key element in the design of gyro-amplifier RF structures is the minimization of unwanted modes. For example, a nonlinear output taper is often employed in the transition from the near cutoff radius of the interacting circuit to a much larger output waveguide, which also serves as the collector. The taper designs are usually done without considering the effect of a bunched beam. However, recent simulations [1] with the self-consistent MAGY code [2] reveal that higher order mode interactions with the bunched electron beam can substantially compromise the mode purity of the RF output. The interaction in the taper region is that of a travelling-wave type and is strongly dependent on the beam bunching characteristics resulting from previous interaction with the operating mode in the interacting circuit. Subsequent to this prediction, an experiment was performed to measure the RF output mode content from a Ka-band gyro-klystron at the Naval Research Laboratory. The agreement between salient theoretical and measured RF output characteristics confirms the existence higher order mode excitation in output tapers as predicted by theory. Another example of the need to employ self-consistent theoretical model in the design of gyro-amplifier RF structures is the phenomenon of beam-induced RF excitation in drift sections, which are cutoff to the operating mode and are used to separate cavities in gyroklystron amplifiers. This non-resonant RF excitation is at the drive frequency and the RF field structure is that of the operating mode. The RF amplitude is found to scale linearly with the bunched beam current. The presence of RF in the drift section has important thermal implications in the design and use of lossy dielectrics in drift-sections, especially for high-average power devices. [1] K. Nguyen, et al., IEEE Trans. Plasma Science, in press 2000. [2] M. Botton, et al., IEEE Trans. Plasma Science, V.26, p.882, June 1998.

  14. Higher-order theories from the minimal length

    NASA Astrophysics Data System (ADS)

    Dias, M.; Hoff da Silva, J. M.; Scatena, E.

    2016-06-01

    We show that the introduction of a minimal length in the context of noncommutative space-time gives rise (after some considerations) to higher-order theories. We then explicitly demonstrate how these higher-derivative theories appear as a generalization of the standard electromagnetism and general relativity by applying a consistent procedure that modifies the original Maxwell and Einstein-Hilbert actions. In order to set a bound on the minimal length, we compare the deviations from the inverse-square law with the potentials obtained in the higher-order theories and discuss the validity of the results. The introduction of a quantum bound for the minimal length parameter β in the higher-order QED allows us to lower the actual limits on the parameters of higher-derivative gravity by almost half of their order of magnitude.

  15. Higher Order Modeling In the BEM/FEM Hybrid Formulation

    NASA Technical Reports Server (NTRS)

    Fink, Patrick W.; Wilton, Don R.

    2000-01-01

    Hybrid formulations using low order curl-conforming bases to represent the total electric field within a finite element region and low order divergence-conforming bases to represent equivalent electric and magnetic currents on the boundary are well known. However, higher-order divergence and curl-conforming bases have been shown to provide significant benefits in convergence rates and accuracy when employed in strictly integral equation and strictly finite element formulations. In this paper, a hybrid electric field formulation employing higher order bases is presented. The paper addresses benefits and issues associated with using higher order divergence-and curl-conforming bases in the hybrid finite element/boundary element electric field formulation. The method of singularity subtraction may be used to compute the self terms of the boundary integral when the bases are of low order. But this method becomes laborious and requires great care when the divergence conforming bases are of higher order. In order to handle these singularities simply and accurately, a generalized Gaussian quadrature method is employed in which the expansion functions account for the singularity. In preliminary tests of the higher order hybrid formulation, the equivalent electric current induced by scattering of a plane wave from a square dielectric cylinder is examined. Accurate results are obtained using only a two-triangle mesh when the current basis is of order 4 or 5. Additional results are presented comparing the error obtained using higher order bases to that obtained using lower order bases when the number of unknowns is approximately equal. Also, convergence rates obtained with higher order bases are compared to those obtained with lower order bases for selected sample problems.

  16. Application of Mass Lumped Higher Order Finite Elements

    SciTech Connect

    Chen, J.; Strauss, H. R.; Jardin, S. C.; Park, W.; Sugiyama, L. E.; G. Fu; Breslau, J.

    2005-11-01

    There are many interesting phenomena in extended-MHD such as anisotropic transport, mhd, 2-fluid effects stellarator and hot particles. Any one of them challenges numerical analysts, and researchers are seeking for higher order methods, such as higher order finite difference, higher order finite elements and hp/spectral elements. It is true that these methods give more accurate solution than their linear counterparts. However, numerically they are prohibitively expensive. Here we give a successful solution of this conflict by applying mass lumped higher order finite elements. This type of elements not only keep second/third order accuracy but also scale closely to linear elements by doing mass lumping. This is especially true for second order lump elements. Full M3D and anisotropic transport models are studied.

  17. Purification and characterization of Ara h1 and Ara h3 from four peanut market types revealed higher order oligomeric structures.

    PubMed

    Yusnawan, Eriyanto; Marquis, Christopher P; Lee, N Alice

    2012-10-17

    This study aimed to purify and characterize the peanut allergens Ara h1 and Ara h3 from four cultivars that represent the four major market types to provide better understanding of the molecular organization of oligomers in different market types. The chromatographic profiles of Ara h1 and Ara h3 from the four cultivars obtained from anion exchange chromatography were similar. However, they differed in the distribution of trimeric and hexameric structures of Ara h3 isolated by size exclusion chromatography. The Menzies (Runner market type) and Walter (Spanish market type) cultivars, wherein Ara h3 proteins consist of two acidic subunits, exhibited trimeric and hexameric conformations proportionally. However, the Middleton (Virginia market type) and Kelinci (Valencia market type) cultivars, wherein Ara h3 proteins consist of three acidic subunits, showed predominantly a hexameric structure. The oligomeric structures of the purified Ara h1 demonstrated strong IgE binding properties, whereas the allergenic property of the oligomeric Ara h3 could not be performed due to lack of availability of specific IgE. In addition, the polyclonal antibodies raised against the purified Ara h1 and Ara h3 showed highly specific binding to their respective antigens. PMID:22998620

  18. Insights into Higher-Order Organization of the Cellulosome Revealed by a Dissect-and build Approach: Crystal Structure of Interacting Clostridium thermocellum Multimodular components

    SciTech Connect

    J Adams; M Currie; S Ali; E Bayer; Z Jia; S Smith

    2011-12-31

    Cellulosomes are large, multienzyme, plant cell wall-degrading protein complexes found affixed to the surface of a variety of anaerobic microbes. The core of the cellulosome is a noncatalytic scaffoldin protein, which contains several type-I cohesin modules that bind type-I dockerin-containing enzymatic subunits, a cellulose-binding module, an X module, and a type-II dockerin that interacts with type-II cohesin-containing cell surface proteins. The unique arrangement of the enzymatic subunits in the cellulosome complex, made possible by the scaffoldin subunit, promotes enhanced substrate degradation relative to the enzymes free in solution. Despite representative high-resolution structures of all of the individual modules of the cellulosome, this mechanism of enzymatic synergy remains poorly understood. Consequently, a model of the entire cellulosome and a detailed picture of intermodular contacts will provide more detailed insight into cellulosome activity. Toward this goal, we have solved the structure of a multimodular heterodimeric complex from Clostridium thermocellum composed of the type-II cohesin module of the cell surface protein SdbA bound to a trimodular C-terminal fragment of the scaffoldin subunit CipA to a resolution of 1.95 {angstrom}. The linker that connects the ninth type-I cohesin module and the X module has elevated temperature factors, reflecting an inherent flexibility within this region. Interestingly, a novel dimer interface was observed between CipA and a second, symmetry-related CipA molecule within the crystal structure, mediated by contacts between a type-I cohesin and an X module of a symmetry mate, resulting in two intertwined scaffoldins. Sedimentation velocity experiments confirmed that dimerization also occurs in solution. These observations support the intriguing possibility that individual cellulosomes can associate with one another via inter-scaffoldin interactions, which may play a role in the mechanism of action of the complex.

  19. Two's company, three (or more) is a simplex : Algebraic-topological tools for understanding higher-order structure in neural data.

    PubMed

    Giusti, Chad; Ghrist, Robert; Bassett, Danielle S

    2016-08-01

    The language of graph theory, or network science, has proven to be an exceptional tool for addressing myriad problems in neuroscience. Yet, the use of networks is predicated on a critical simplifying assumption: that the quintessential unit of interest in a brain is a dyad - two nodes (neurons or brain regions) connected by an edge. While rarely mentioned, this fundamental assumption inherently limits the types of neural structure and function that graphs can be used to model. Here, we describe a generalization of graphs that overcomes these limitations, thereby offering a broad range of new possibilities in terms of modeling and measuring neural phenomena. Specifically, we explore the use of simplicial complexes: a structure developed in the field of mathematics known as algebraic topology, of increasing applicability to real data due to a rapidly growing computational toolset. We review the underlying mathematical formalism as well as the budding literature applying simplicial complexes to neural data, from electrophysiological recordings in animal models to hemodynamic fluctuations in humans. Based on the exceptional flexibility of the tools and recent ground-breaking insights into neural function, we posit that this framework has the potential to eclipse graph theory in unraveling the fundamental mysteries of cognition. PMID:27287487

  20. Technical Decision-Making with Higher Order Structure Data: Detecting Reversible Concentration-Dependent Self-Association in a Monoclonal Antibody and a Preliminary Investigation to Eliminate It.

    PubMed

    Wei, Julie Y; Bou-Assaf, George M; Houde, Damian; Weiskopf, Andrew

    2015-11-01

    Protein self-association or aggregation is a property of significant concern for biopharmaceutical products due to the potential ability of aggregates to cause adverse toxicological and immunological effects. Thus, during the development of a protein biopharmaceutical, it is important to detect and quantify the level and nature of aggregate species as early as possible in order to make well-informed decisions and to mitigate and control potential risks. Although a deeper understanding of the mechanism of aggregation (i.e., protein-protein interactions) is desirable, such detailed assessment is not always necessary from a biopharmaceutical process development point of view. In fact, the scope of characterization efforts is often focused on achieving a well-controlled process, which generates a product that reliably meets established acceptance criteria for safety and efficacy. In this brief note, we evaluated the utility of size-exclusion chromatography, dynamic light scattering, and analytical ultracentrifugation in their simplest forms, to effectively reveal and confirm the presence of concentration-dependent reversible self-association (RSA) in a monoclonal antibody in the early stages of formulation development. Using these techniques, we also initiated preliminary work aimed at reducing the occurrence of this RSA behavior by varying the pH of the formulation buffer. PMID:26308556

  1. On higher order geometric and renormalization group flows

    NASA Astrophysics Data System (ADS)

    Prabhu, Kartik; Das, Sanjit; Kar, Sayan

    2011-10-01

    Renormalization group (RG) flows of the bosonic nonlinear σ-model are governed, perturbatively, at different orders of α', by perturbatively evaluated β-functions. In regions where {α'}/{Rc2}≪1 ( {1}/{Rc2} represents the curvature scale), the flow equations at various orders in α' can be thought of as approximating the full, non-perturbative RG flow. On the other hand, taking a different viewpoint, we may consider the above-mentioned RG flow equations as viable geometric flows in their own right, without any reference to the RG aspect. Looked at as purely geometric flows where higher order terms appear, we no longer have the perturbative restrictions (small curvatures). In this paper, we perform our analysis from both these perspectives using specific target manifolds such as S2, H2, unwarped S2×H2 and simple warped products. We analyse and solve the higher order RG flow equations within the appropriate perturbative domains and find the corrections arising due to the inclusion of higher order terms. Such corrections, within the perturbative regime, are shown to be small and they provide an estimate of the error that arises when higher orders are ignored. We also investigate higher order geometric flows on the same manifolds and figure out generic features of geometric evolution, the appearance of singularities and solitons. The aim, in this context, is to demonstrate the role of higher order terms in modifying the flow. One interesting aspect of our analysis is that, separable solutions of the higher order flow equations for simple warped spacetimes (of the kind used in bulk-brane models with a single extra dimension), correspond to constant curvature anti de Sitter (AdS) spacetimes, modulo an overall flow parameter dependent scale factor. The functional form of this scale factor (that we obtain) changes on the inclusion of successive higher order terms in the flow.

  2. Higher-order phase transitions on financial markets

    NASA Astrophysics Data System (ADS)

    Kasprzak, A.; Kutner, R.; Perelló, J.; Masoliver, J.

    2010-08-01

    Statistical and thermodynamic properties of the anomalous multifractal structure of random interevent (or intertransaction) times were thoroughly studied by using the extended continuous-time random walk (CTRW) formalism of Montroll, Weiss, Scher, and Lax. Although this formalism is quite general (and can be applied to any interhuman communication with nontrivial priority), we consider it in the context of a financial market where heterogeneous agent activities can occur within a wide spectrum of time scales. As the main general consequence, we found (by additionally using the Saddle-Point Approximation) the scaling or power-dependent form of the partition function, Z(q'). It diverges for any negative scaling powers q' (which justifies the name anomalous) while for positive ones it shows the scaling with the general exponent τ(q'). This exponent is the nonanalytic (singular) or noninteger power of q', which is one of the pilar of higher-order phase transitions. In definition of the partition function we used the pausing-time distribution (PTD) as the central one, which takes the form of convolution (or superstatistics used, e.g. for describing turbulence as well as the financial market). Its integral kernel is given by the stretched exponential distribution (often used in disordered systems). This kernel extends both the exponential distribution assumed in the original version of the CTRW formalism (for description of the transient photocurrent measured in amorphous glassy material) as well as the Gaussian one sometimes used in this context (e.g. for diffusion of hydrogen in amorphous metals or for aging effects in glasses). Our most important finding is the third- and higher-order phase transitions, which can be roughly interpreted as transitions between the phase where high frequency trading is most visible and the phase defined by low frequency trading. The specific order of the phase transition directly depends upon the shape exponent α defining the stretched

  3. Chromatin higher-order structure: two-start double superhelix formed by zig-zag shaped nucleosome chain with folded linker DNA.

    PubMed

    Osipova, T N; Karpova, E V; Vorob'ev, V I

    1990-08-01

    Hydrodynamic properties of chromatins differing in linker DNA length and in transcriptional activity have been studied by the method of sedimentation velocity. Oligonucleosomes of different chain length were isolated from chromatins of pigeon brain cortical neurones, rat thymus and sea urchin sperm characterized by nucleosome DNA repeat length of 165, 198 and 248 base pairs respectively. The hydrodynamic behaviour of oligonucleosomes in the dependence on the number of nucleosomes in the chain and on the ionic strength has been analysed on the basis of cylinder model. The data obtained allows one to calculate the main structural parameters of the oligonucleosomal chain: its mass per unit length, the hydrodynamic diameter of the chain, the length of the chain per nucleosome and DNA packing ratio. It is shown that hydrodynamic behaviour of nucleosome oligomers from all types of chromatins investigated at low ionic strength can be well described by the model of three-dimensional zig-zag chain with similar diameter and length of the chain per nucleosome, DNA packing ratio growing with the increase of linker DNA length. It can be achieved by unfolding the short linker DNA in neurone chromatin and by coiling the long linker DNA of sea urchin sperm chromatin into a loop. With the increase of ionic strength zig-zag shaped nucleosomal chain is condensed into a two-start double superhelix with closely arranged nucleosomes and linker DNA loops packed inside the superhelix. The suggested model is in good agreement with available experimental data and overcomes a number of difficulties which arise for the solenoid model and other models of the 30-nm chromatin fibril. PMID:2275789

  4. A Testing Theory for a Higher-Order Cryptographic Language

    NASA Astrophysics Data System (ADS)

    Koutavas, Vasileios; Hennessy, Matthew

    We study a higher-order concurrent language with cryptographic primitives, for which we develop a sound and complete, first-order testing theory for the preservation of safety properties. Our theory is based on co-inductive set simulations over transitions in a first-order Labelled Transition System. This keeps track of the knowledge of the observer, and treats transmitted higher-order values in a symbolic manner, thus obviating the quantification over functional contexts. Our characterisation provides an attractive proof technique, and we illustrate its usefulness in proofs of equivalence, including cases where bisimulation theory does not apply.

  5. Superposition rules for higher order systems and their applications

    NASA Astrophysics Data System (ADS)

    Cariñena, J. F.; Grabowski, J.; de Lucas, J.

    2012-05-01

    Superposition rules form a class of functions that describe general solutions of systems of first-order ordinary differential equations in terms of generic families of particular solutions and certain constants. In this work, we extend this notion and other related ones to systems of higher order differential equations and analyse their properties. Several results concerning the existence of various types of superposition rules for higher order systems are proved and illustrated with examples extracted from the physics and mathematics literature. In particular, two new superposition rules for the second- and third-order Kummer-Schwarz equations are derived.

  6. Unambiguous formalism for higher order Lagrangian field theories

    NASA Astrophysics Data System (ADS)

    Campos, Cédric M.; de León, Manuel; Martín de Diego, David; Vankerschaver, Joris

    2009-11-01

    The aim of this paper is to propose an unambiguous intrinsic formalism for higher order field theories which avoids the arbitrariness in the generalization of the conventional description of field theories, and implies the existence of different Cartan forms and Legendre transformations. We propose a differential-geometric setting for the dynamics of a higher order field theory, based on the Skinner and Rusk formalism for mechanics. This approach incorporates aspects of both the Lagrangian and the Hamiltonian description, since the field equations are formulated using the Lagrangian on a higher order jet bundle and the canonical multisymplectic form on its affine dual. As both of these objects are uniquely defined, the Skinner-Rusk approach has the advantage that it does not suffer from the arbitrariness in conventional descriptions. The result is that we obtain a unique and global intrinsic version of the Euler-Lagrange equations for higher order field theories. Several examples illustrate our construction.

  7. On the Evaluation of Higher-Order Science Instructional Objectives

    ERIC Educational Resources Information Center

    Hambleton, Ronald K.; Sheehan, Daniel S.

    1977-01-01

    Advocates the use of a free-sort categorization technique for evaluation of higher-order science instructional objectives. An explanation and demonstration of the use of the evaluation technique with 284 ninth-grade science students is provided. (CP)

  8. The Lagrangian-Hamiltonian formalism for higher order field theories

    NASA Astrophysics Data System (ADS)

    Vitagliano, Luca

    2010-06-01

    We generalize the Lagrangian-Hamiltonian formalism of Skinner and Rusk to higher order field theories on fiber bundles. As a byproduct we solve the long standing problem of defining, in a coordinate free manner, a Hamiltonian formalism for higher order Lagrangian field theories. Namely, our formalism does only depend on the action functional and, therefore, unlike previously proposed ones, is free from any relevant ambiguity.

  9. Higher order derivatives of R-Jacobi polynomials

    NASA Astrophysics Data System (ADS)

    Das, Sourav; Swaminathan, A.

    2016-06-01

    In this work, the R-Jacobi polynomials defined on the nonnegative real axis related to F-distribution are considered. Using their Sturm-Liouville system higher order derivatives are constructed. Orthogonality property of these higher ordered R-Jacobi polynomials are obtained besides their normal form, self-adjoint form and hypergeometric representation. Interesting results on the Interpolation formula and Gaussian quadrature formulae are obtained with numerical examples.

  10. Higher Order Lagrange Finite Elements In M3D

    SciTech Connect

    J. Chen; H.R. Strauss; S.C. Jardin; W. Park; L.E. Sugiyama; G. Fu; J. Breslau

    2004-12-17

    The M3D code has been using linear finite elements to represent multilevel MHD on 2-D poloidal planes. Triangular higher order elements, up to third order, are constructed here in order to provide M3D the capability to solve highly anisotropic transport problems. It is found that higher order elements are essential to resolve the thin transition layer characteristic of the anisotropic transport equation, particularly when the strong anisotropic direction is not aligned with one of the Cartesian coordinates. The transition layer is measured by the profile width, which is zero for infinite anisotropy. It is shown that only higher order schemes have the ability to make this layer converge towards zero when the anisotropy gets stronger and stronger. Two cases are considered. One has the strong transport direction partially aligned with one of the element edges, the other doesn't have any alignment. Both cases have the strong transport direction misaligned with the grid line by some angles.

  11. Higher-order Fourier analysis over finite fields and applications

    NASA Astrophysics Data System (ADS)

    Hatami, Pooya

    Higher-order Fourier analysis is a powerful tool in the study of problems in additive and extremal combinatorics, for instance the study of arithmetic progressions in primes, where the traditional Fourier analysis comes short. In recent years, higher-order Fourier analysis has found multiple applications in computer science in fields such as property testing and coding theory. In this thesis, we develop new tools within this theory with several new applications such as a characterization theorem in algebraic property testing. One of our main contributions is a strong near-equidistribution result for regular collections of polynomials. The densities of small linear structures in subsets of Abelian groups can be expressed as certain analytic averages involving linear forms. Higher-order Fourier analysis examines such averages by approximating the indicator function of a subset by a function of bounded number of polynomials. Then, to approximate the average, it suffices to know the joint distribution of the polynomials applied to the linear forms. We prove a near-equidistribution theorem that describes these distributions for the group F(n/p) when p is a fixed prime. This fundamental fact was previously known only under various extra assumptions about the linear forms or the field size. We use this near-equidistribution theorem to settle a conjecture of Gowers and Wolf on the true complexity of systems of linear forms. Our next application is towards a characterization of testable algebraic properties. We prove that every locally characterized affine-invariant property of functions f : F(n/p) → R with n∈ N, is testable. In fact, we prove that any such property P is proximity-obliviously testable. More generally, we show that any affine-invariant property that is closed under subspace restrictions and has "bounded complexity" is testable. We also prove that any property that can be described as the property of decomposing into a known structure of low

  12. Higher-order graph wavelets and sparsity on circulant graphs

    NASA Astrophysics Data System (ADS)

    Kotzagiannidis, Madeleine S.; Dragotti, Pier Luigi

    2015-08-01

    The notion of a graph wavelet gives rise to more advanced processing of data on graphs due to its ability to operate in a localized manner, across newly arising data-dependency structures, with respect to the graph signal and underlying graph structure, thereby taking into consideration the inherent geometry of the data. In this work, we tackle the problem of creating graph wavelet filterbanks on circulant graphs for a sparse representation of certain classes of graph signals. The underlying graph can hereby be data-driven as well as fixed, for applications including image processing and social network theory, whereby clusters can be modelled as circulant graphs, respectively. We present a set of novel graph wavelet filter-bank constructions, which annihilate higher-order polynomial graph signals (up to a border effect) defined on the vertices of undirected, circulant graphs, and are localised in the vertex domain. We give preliminary results on their performance for non-linear graph signal approximation and denoising. Furthermore, we provide extensions to our previously developed segmentation-inspired graph wavelet framework for non-linear image approximation, by incorporating notions of smoothness and vanishing moments, which further improve performance compared to traditional methods.

  13. Image Segmentation Using Higher-Order Correlation Clustering.

    PubMed

    Kim, Sungwoong; Yoo, Chang D; Nowozin, Sebastian; Kohli, Pushmeet

    2014-09-01

    In this paper, a hypergraph-based image segmentation framework is formulated in a supervised manner for many high-level computer vision tasks. To consider short- and long-range dependency among various regions of an image and also to incorporate wider selection of features, a higher-order correlation clustering (HO-CC) is incorporated in the framework. Correlation clustering (CC), which is a graph-partitioning algorithm, was recently shown to be effective in a number of applications such as natural language processing, document clustering, and image segmentation. It derives its partitioning result from a pairwise graph by optimizing a global objective function such that it simultaneously maximizes both intra-cluster similarity and inter-cluster dissimilarity. In the HO-CC, the pairwise graph which is used in the CC is generalized to a hypergraph which can alleviate local boundary ambiguities that can occur in the CC. Fast inference is possible by linear programming relaxation, and effective parameter learning by structured support vector machine is also possible by incorporating a decomposable structured loss function. Experimental results on various data sets show that the proposed HO-CC outperforms other state-of-the-art image segmentation algorithms. The HO-CC framework is therefore an efficient and flexible image segmentation framework. PMID:26352230

  14. Unified formalism for higher order non-autonomous dynamical systems

    NASA Astrophysics Data System (ADS)

    Prieto-Martínez, Pedro Daniel; Román-Roy, Narciso

    2012-03-01

    This work is devoted to giving a geometric framework for describing higher order non-autonomous mechanical systems. The starting point is to extend the Lagrangian-Hamiltonian unified formalism of Skinner and Rusk for these kinds of systems, generalizing previous developments for higher order autonomous mechanical systems and first-order non-autonomous mechanical systems. Then, we use this unified formulation to derive the standard Lagrangian and Hamiltonian formalisms, including the Legendre-Ostrogradsky map and the Euler-Lagrange and the Hamilton equations, both for regular and singular systems. As applications of our model, two examples of regular and singular physical systems are studied.

  15. Higher-order conditioning and the retrosplenial cortex.

    PubMed

    Todd, Travis P; Huszár, Roman; DeAngeli, Nicole E; Bucci, David J

    2016-09-01

    The retrosplenial cortex (RSC) is known to contribute to contextual and spatial learning and memory. This is consistent with its well-established connectivity; the RSC is located at the interface of visuo-spatial association areas and the parahippocampal-hippocampal memory system. However, the RSC also contributes to learning and memory for discrete cues. For example, both permanent lesions and temporary inactivation of the RSC have been shown to impair sensory preconditioning, a form of higher-order conditioning. The purpose of the present experiment was to examine the role of the RSC in a closely related higher-order conditioning paradigm: second-order conditioning. Sham and RSC lesioned rats received first-order conditioning in which one visual stimulus (V1) was paired with footshock and one visual stimulus (V2) was not. Following first-order conditioning, one auditory stimulus (A1) was then paired with V1 and a second auditory stimulus (A2) was paired with V2. Although lesions of the RSC impaired the first-order discrimination, they had no impact on the acquisition of second-order conditioning. Thus, the RSC does not appear necessary for acquisition/expression of second-order fear conditioning. The role of the RSC in higher-order conditioning, as well as a possible dissociation from the hippocampus, is discussed. PMID:27208598

  16. Optimized higher-order automatic differentiation for the Faddeeva function

    NASA Astrophysics Data System (ADS)

    Charpentier, Isabelle

    2016-08-01

    Considerable research efforts have been directed at implementing the Faddeeva function w(z) and its derivatives with respect to z, but these did not consider the key computing issue of a possible dependence of z on some variable t. The general case is to differentiate the compound function w(z(t)) = w ∘ z(t) with respect to t by applying the chain rule for a first order derivative, or Faà di Bruno's formula for higher-order ones. Higher-order automatic differentiation (HOAD) is an efficient and accurate technique for derivative calculation along scientific computing codes. Although codes are available for w(z) , a special symbolic HOAD is required to compute accurate higher-order derivatives for w ∘ z(t) in an efficient manner. A thorough evaluation is carried out considering a nontrivial case study in optics to support this assertion.

  17. Ordered chlorinated monolayer silicene structures

    NASA Astrophysics Data System (ADS)

    Li, Wenbin; Sheng, Shaoxiang; Chen, Jian; Cheng, Peng; Chen, Lan; Wu, Kehui

    2016-04-01

    We report on a systematic experimental study on the chlorination of monatomic silicene layer on Ag(111) by scanning tunneling microscopy. Monolayer silicene on Ag(111) can form 4×4, (√13×√13)R ± 13.9°, and (2√3×2√3)R30° reconstructions due to their different buckling configurations. We found that at low dosage, Cl atoms attach to the upper buckled Si atoms without changing the buckling configuration of the silicene monolayer. However, at high coverage, the global buckling configuration will be significantly changed, resulting in new ordered structures. Interestingly, all monolayer silicene structures, regardless of their initial reconstructions, tend to form a local silicene 1×1 structure at the saturation coverage. The mechanism for chlorination of monolayer silicene is explained.

  18. Evidence for higher-order structure formation by the c-myb 18-mer phosphorothioate antisense (codons 2-7) oligodeoxynucleotide: potential relationship to antisense c-myb inhibition.

    PubMed

    Vilenchik, M; Benimetsky, L; Kolbanovsky, A; Miller, P; Stein, C A

    2001-04-01

    We have demonstrated the formation of higher-order structures (presumably tetraplexes) by an 18-mer phosphorothioate antisense c-myb oligodeoxyribonucleotide that has been shown to have activity in the treatment of leukemia xenograft models. Although not observable by conventionally employed techniques, such as PAGE and dimethyl sulfate (DMS) protection, the formation of such higher-order structures by this oligonucleotide was revealed by several techniques. These included capillary gel electrophoresis (CGE), which demonstrated the presence of molecules with greatly increased retention time compared with the monomer; magnetic circular dichroism spectroscopy, which demonstrated a band at 290 nm, a characteristic of antiparallel tetraplexes; and fluorescence energy transfer measurements. For the last, the 18-mer phosphorothioate oligonucleotide was synthesized with a 5'-fluorescein group. Similar to the molecular beacon model, its fluorescence was quenched when combined in solution with tetraplex-forming oligomers that contained a 3'-Dabcyl moiety. 7-Deazaguanosine inhibits the formation of tetraplexes by eliminated Hoogsteen base pair interactions. The wild-type and 7-deazaguanosine-substituted antisense c-myb oligomers differentially downregulated the expression of the c-myb proto-oncogene in K562 and HL60 cells, with the wild-type oligomer being the least active. The 18-mer c-myb molecule can, therefore, form highly complex structures, whose analysis in solution cannot be limited to examination of slab gel electrophoresis results alone. PMID:11334144

  19. The Serenity of the Meditating Mind: A Cross-Cultural Psychometric Study on a Two-Factor Higher Order Structure of Mindfulness, Its Effects, and Mechanisms Related to Mental Health among Experienced Meditators

    PubMed Central

    Tran, Ulrich S.; Cebolla, Ausiàs; Glück, Tobias M.; Soler, Joaquim; Garcia-Campayo, Javier; von Moy, Theresa

    2014-01-01

    Objective To investigate the psychometric and structural properties of the Five Facets Mindfulness Questionnaire (FFMQ) among meditators, to develop a short form, and to examine associations of mindfulness with mental health and the mechanisms of mindfulness. Methods Two independent samples were used, a German (n = 891) and a Spanish (n = 393) meditator sample, practicing various meditation styles. Structural and psychometric properties of the FFMQ were investigated with multigroup confirmatory factor analysis and exploratory structural equation modeling. Associations with mental health and mechanisms of mindfulness were examined with path analysis. Results The derived short form broadly matched a previous item selection in samples of non-meditators. Self-regulated Attention and Orientation to Experience governed the facets of mindfulness on a higher-order level. Higher-order factors of mindfulness and meditation experience were negatively associated with symptoms of depression and anxiety, and perceived stress. Decentering and nonattachment were the most salient mechanisms of mindfulness. Aspects of emotion regulation, bodily awareness, and nonattachment explained the effects of mindfulness on depression and anxiety. Conclusions A two-component conceptualization for the FFMQ, and for the study of mindfulness as a psychological construct, is recommended for future research. Mechanisms of mindfulness need to be examined in intervention studies. PMID:25330072

  20. Higher-order motion sensitivity in fly visual circuits.

    PubMed

    Lee, Yu-Jen; Nordström, Karin

    2012-05-29

    In higher-order motion stimuli, the direction of object motion does not follow the direction of luminance change. Such stimuli could be generated by the wing movements of a flying butterfly and further complicated by its motion in and out of shadows. Human subjects readily perceive the direction of higher-order motion, although this stands in stark contrast to prevailing motion vision models. Flies and humans compute motion in similar ways, and because flies behaviorally track bars containing higher-order motion cues, they become an attractive model system for investigating the neurophysiology underlying higher-order motion sensitivity. We here use intracellular electrophysiology of motion-vision-sensitive neurons in the hoverfly lobula plate to quantify responses to stimuli containing higher-order motion. We show that motion sensitivity can be broken down into two separate streams, directionally coding for elementary motion and figure motion, respectively, and that responses to Fourier and theta motion can be predicted from these. The sensitivity is affected both by the stimulus' time course and by the neuron's underlying receptive field. Responses to preferred-direction theta motion are sexually dimorphic and particularly robust along the visual midline. PMID:22586123

  1. Higher-order motion sensitivity in fly visual circuits

    PubMed Central

    Lee, Yu-Jen; Nordström, Karin

    2012-01-01

    In higher-order motion stimuli, the direction of object motion does not follow the direction of luminance change. Such stimuli could be generated by the wing movements of a flying butterfly and further complicated by its motion in and out of shadows. Human subjects readily perceive the direction of higher-order motion, although this stands in stark contrast to prevailing motion vision models. Flies and humans compute motion in similar ways, and because flies behaviorally track bars containing higher-order motion cues, they become an attractive model system for investigating the neurophysiology underlying higher-order motion sensitivity. We here use intracellular electrophysiology of motion-vision–sensitive neurons in the hoverfly lobula plate to quantify responses to stimuli containing higher-order motion. We show that motion sensitivity can be broken down into two separate streams, directionally coding for elementary motion and figure motion, respectively, and that responses to Fourier and theta motion can be predicted from these. The sensitivity is affected both by the stimulus’ time course and by the neuron’s underlying receptive field. Responses to preferred-direction theta motion are sexually dimorphic and particularly robust along the visual midline. PMID:22586123

  2. Dynamics and control of higher-order nonholonomic systems

    NASA Astrophysics Data System (ADS)

    Rubio Hervas, Jaime

    A theoretical framework is established for the control of higher-order nonholonomic systems, defined as systems that satisfy higher-order nonintegrable constraints. A model for such systems is developed in terms of differential-algebraic equations defined on a higher-order tangent bundle. A number of control-theoretic properties such as nonintegrability, controllability, and stabilizability are presented. Higher-order nonholonomic systems are shown to be strongly accessible and, under certain conditions, small time locally controllable at any equilibrium. There are important examples of higher-order nonholonomic systems that are asymptotically stabilizable via smooth feedback, including space vehicles with multiple slosh modes and Prismatic-Prismatic-Revolute (PPR) robots moving open liquid containers, as well as an interesting class of systems that do not admit asymptotically stabilizing continuous static or dynamic state feedback. Specific assumptions are introduced to define this class, which includes important examples of robotic systems. A discontinuous nonlinear feedback control algorithm is developed to steer any initial state to the equilibrium at the origin. The applicability of the theoretical development is illustrated through two examples: control of a planar PPR robot manipulator subject to a jerk constraint and control of a point mass moving on a constant torsion curve in a three dimensional space.

  3. Ordered structures and jet noise

    NASA Technical Reports Server (NTRS)

    Petersen, R. A.; Kaplan, R. E.; Laufer, J.

    1974-01-01

    A series of measurements of near field pressures and turbulent velocity fluctuations were made in a jet having a Reynolds number of about 50,000 in order to investigate more quantitatively the character and behavior of the large scale structures, and to ascertain their importance to the jet noise problem. It was found that the process of interaction between vortices can be inhibited by artificially exciting the shear layers with periodic disturbances of certain frequency. The turbulent fluctuation amplitudes measured at four diameters downstream decreased considerably. Finally, it was observed that the passage frequency of the structures decreased with x in a similar manner as the frequency corresponding to the maximum intensity radiation emanating from the same value of x.

  4. Higher-Order Synaptic Interactions Coordinate Dynamics in Recurrent Networks

    PubMed Central

    Chambers, Brendan; MacLean, Jason N.

    2016-01-01

    Linking synaptic connectivity to dynamics is key to understanding information processing in neocortex. Circuit dynamics emerge from complex interactions of interconnected neurons, necessitating that links between connectivity and dynamics be evaluated at the network level. Here we map propagating activity in large neuronal ensembles from mouse neocortex and compare it to a recurrent network model, where connectivity can be precisely measured and manipulated. We find that a dynamical feature dominates statistical descriptions of propagating activity for both neocortex and the model: convergent clusters comprised of fan-in triangle motifs, where two input neurons are themselves connected. Fan-in triangles coordinate the timing of presynaptic inputs during ongoing activity to effectively generate postsynaptic spiking. As a result, paradoxically, fan-in triangles dominate the statistics of spike propagation even in randomly connected recurrent networks. Interplay between higher-order synaptic connectivity and the integrative properties of neurons constrains the structure of network dynamics and shapes the routing of information in neocortex. PMID:27542093

  5. Spectral imaging to visualize higher-order genomic organization.

    PubMed

    Sawyer, Iain A; Shevtsov, Sergei P; Dundr, Miroslav

    2016-05-01

    A concern in the field of genomics is the proper interpretation of large, high-throughput sequencing datasets. The use of DNA FISH followed by high-content microscopy is a valuable tool for validation and contextualization of frequently occurring gene pairing events at the single-cell level identified by deep sequencing. However, these techniques possess certain limitations. Firstly, they do not permit the study of colocalization of many gene loci simultaneously. Secondly, the direct assessment of the relative position of many clustered gene loci within their respective chromosome territories is impossible. Thus, methods are required to advance the study of higher-order nuclear and cellular organization. Here, we describe a multiplexed DNA FISH technique combined with indirect immunofluorescence to study the relative position of 6 distinct genomic or cellular structures. This can be achieved in a single hybridization step using spectral imaging during image acquisition and linear unmixing. Here, we detail the use of this method to quantify gene pairing between highly expressed spliceosomal genes and compare these data to randomly positioned in silico simulated gene clusters. This is a potentially universally applicable approach for the validation of 3C-based technologies, deep imaging of spatial organization within the nucleus and global cellular organization. PMID:27167405

  6. Generation of Higher Order Modes in a Rectangular Duct

    NASA Technical Reports Server (NTRS)

    Gerhold, Carl H.; Cabell, Randolph H.; Brown, Donald E.

    2004-01-01

    Advanced noise control methodologies to reduce sound emission from aircraft engines take advantage of the modal structure of the noise in the duct. This noise is caused by the interaction of rotor wakes with downstream obstructions such as exit guide vanes. Mode synthesis has been accomplished in circular ducts and current active noise control work has made use of this capability to cancel fan noise. The goal of the current effort is to examine the fundamental process of higher order mode propagation through an acoustically treated, curved duct. The duct cross-section is rectangular to permit greater flexibility in representation of a range of duct curvatures. The work presented is the development of a feedforward control system to generate a user-specified modal pattern in the duct. The multiple-error, filtered-x LMS algorithm is used to determine the magnitude and phase of signal input to the loudspeakers to produce a desired modal pattern at a set of error microphones. Implementation issues, including loudspeaker placement and error microphone placement, are discussed. Preliminary results from a 9-3/8 inch by 21 inch duct, using 12 loudspeakers and 24 microphones, are presented. These results demonstrate the ability of the control system to generate a user-specified mode while suppressing undesired modes.

  7. Higher-Order Synaptic Interactions Coordinate Dynamics in Recurrent Networks.

    PubMed

    Chambers, Brendan; MacLean, Jason N

    2016-08-01

    Linking synaptic connectivity to dynamics is key to understanding information processing in neocortex. Circuit dynamics emerge from complex interactions of interconnected neurons, necessitating that links between connectivity and dynamics be evaluated at the network level. Here we map propagating activity in large neuronal ensembles from mouse neocortex and compare it to a recurrent network model, where connectivity can be precisely measured and manipulated. We find that a dynamical feature dominates statistical descriptions of propagating activity for both neocortex and the model: convergent clusters comprised of fan-in triangle motifs, where two input neurons are themselves connected. Fan-in triangles coordinate the timing of presynaptic inputs during ongoing activity to effectively generate postsynaptic spiking. As a result, paradoxically, fan-in triangles dominate the statistics of spike propagation even in randomly connected recurrent networks. Interplay between higher-order synaptic connectivity and the integrative properties of neurons constrains the structure of network dynamics and shapes the routing of information in neocortex. PMID:27542093

  8. Higher-order web link analysis using multilinear algebra.

    SciTech Connect

    Kenny, Joseph P.; Bader, Brett William; Kolda, Tamara Gibson

    2005-07-01

    Linear algebra is a powerful and proven tool in web search. Techniques, such as the PageRank algorithm of Brin and Page and the HITS algorithm of Kleinberg, score web pages based on the principal eigenvector (or singular vector) of a particular non-negative matrix that captures the hyperlink structure of the web graph. We propose and test a new methodology that uses multilinear algebra to elicit more information from a higher-order representation of the hyperlink graph. We start by labeling the edges in our graph with the anchor text of the hyperlinks so that the associated linear algebra representation is a sparse, three-way tensor. The first two dimensions of the tensor represent the web pages while the third dimension adds the anchor text. We then use the rank-1 factors of a multilinear PARAFAC tensor decomposition, which are akin to singular vectors of the SVD, to automatically identify topics in the collection along with the associated authoritative web pages.

  9. A general higher-order remap algorithm for ALE calculations

    SciTech Connect

    Chiravalle, Vincent P

    2011-01-05

    A numerical technique for solving the equations of fluid dynamics with arbitrary mesh motion is presented. The three phases of the Arbitrary Lagrangian Eulerian (ALE) methodology are outlined: the Lagrangian phase, grid relaxation phase and remap phase. The Lagrangian phase follows a well known approach from the HEMP code; in addition the strain rate andflow divergence are calculated in a consistent manner according to Margolin. A donor cell method from the SALE code forms the basis of the remap step, but unlike SALE a higher order correction based on monotone gradients is also added to the remap. Four test problems were explored to evaluate the fidelity of these numerical techniques, as implemented in a simple test code, written in the C programming language, called Cercion. Novel cell-centered data structures are used in Cercion to reduce the complexity of the programming and maximize the efficiency of memory usage. The locations of the shock and contact discontinuity in the Riemann shock tube problem are well captured. Cercion demonstrates a high degree of symmetry when calculating the Sedov blast wave solution, with a peak density at the shock front that is similar to the value determined by the RAGE code. For a flyer plate test problem both Cercion and FLAG give virtually the same velocity temporal profile at the target-vacuum interface. When calculating a cylindrical implosion of a steel shell, Cercion and FLAG agree well and the Cercion results are insensitive to the use of ALE.

  10. Vakonomic Constraints in Higher-Order Classical Field Theory

    NASA Astrophysics Data System (ADS)

    Campos, Cédric M.

    2010-07-01

    We propose a differential-geometric setting for the dynamics of a higher-order field theory, based on the Skinner and Rusk formalism for mechanics. This approach incorporates aspects of both, the Lagrangian and the Hamiltonian description, since the field equations are formulated using the Lagrangian on a higher-order jet bundle and the canonical multisymplectic form on its affine dual. The result is that we obtain a unique and global intrinsic description of the dynamics. The case of vakonomic constraints is also studied within this formalism.

  11. Breaking the symmetry for enhanced higher-order mode delocalization

    NASA Astrophysics Data System (ADS)

    Stutzki, Fabian; Jansen, Florian; Jauregui, Cesar; Limpert, Jens; Tünnermann, Andreas

    2014-03-01

    Large-pitch fibers (LPFs) have enabled the current records for average power, pulse energy and pulse peak power in ultra-fast fiber laser systems. In this paper the working principle of LPFs, which is based on higher-order mode delocalization, is numerically analyzed paying special attention to thermal effects and index mismatch. An enhanced design concept is proposed with a reduced symmetry to improve the delocalization of higher-order modes. This enhanced design has been obtained by transferring the most important characteristics of spiral geometries to a common hexagonal lattice.

  12. Higher order mode laser beam scintillations in oceanic medium

    NASA Astrophysics Data System (ADS)

    Baykal, Yahya

    2016-01-01

    In a horizontal oceanic optical wireless communication link, the scintillation index (the measure for the intensity fluctuations) of the received intensity caused by the oceanic turbulence is formulated and evaluated when the source is a higher order mode laser. Variations in the scintillation index vs. the underwater turbulence parameters, size of the higher order mode laser source, link length, and the wavelength are examined. Underwater turbulence parameters are the ratio that determines the relative strength of temperature and salinity in driving the index fluctuations, the rate of dissipation of the mean squared temperature, the rate of dissipation of the turbulent kinetic energy, and the Kolmogorov microscale length.

  13. Numerical modeling of higher order magnetic moments in UXO discrimination

    USGS Publications Warehouse

    Sanchez, V.; Yaoguo, L.; Nabighian, M.N.; Wright, D.L.

    2008-01-01

    The surface magnetic anomaly observed in unexploded ordnance (UXO) clearance is mainly dipolar, and consequently, the dipole is the only magnetic moment regularly recovered in UXO discrimination. The dipole moment contains information about the intensity of magnetization but lacks information about the shape of the target. In contrast, higher order moments, such as quadrupole and octupole, encode asymmetry properties of the magnetization distribution within the buried targets. In order to improve our understanding of magnetization distribution within UXO and non-UXO objects and to show its potential utility in UXO clearance, we present a numerical modeling study of UXO and related metallic objects. The tool for the modeling is a nonlinear integral equation describing magnetization within isolated compact objects of high susceptibility. A solution for magnetization distribution then allows us to compute the magnetic multipole moments of the object, analyze their relationships, and provide a depiction of the anomaly produced by different moments within the object. Our modeling results show the presence of significant higher order moments for more asymmetric objects, and the fields of these higher order moments are well above the noise level of magnetic gradient data. The contribution from higher order moments may provide a practical tool for improved UXO discrimination. ?? 2008 IEEE.

  14. Higher Order Mode Coupler Heating in Continuous Wave Operation

    NASA Astrophysics Data System (ADS)

    Solyak, N.; Awida, M.; Hocker, A.; Khabibobulline, T.; Lunin, A.

    Electromagnetic heating due to higher order modes (HOM) propagation is particularly a concern for continuous wave (CW) particle accelerator machines. Power on the order of several watts could flow out of the cavity's HOM ports in CW operations. The upgrade of the Linac Coherent Light Source (LCLS-II) at SLAC requires a major modification of the design of the higher order mode (HOM) antenna and feed through of the conventional ILC elliptical 9-cell cavity in order to utilize it for LCLS-II. The HOM antenna is required to bear higher RF losses, while relatively maintaining the coupling level of the higher order modes. In this paper, we present a detailed analysis of the heating expected in the HOM coupler with a thorough thermal quench study in comparison with the conventional ILC design. We discuss also how the heat will be removed from the cavity through RF cables with specially designed cooling straps. Finally, we report on the latest experimental results of cavity testing in vertical and horizontal cryostats.

  15. Higher order matrix differential equations with singular coefficient matrices

    SciTech Connect

    Fragkoulis, V. C.; Kougioumtzoglou, I. A.; Pantelous, A. A.; Pirrotta, A.

    2015-03-10

    In this article, the class of higher order linear matrix differential equations with constant coefficient matrices and stochastic process terms is studied. The coefficient of the highest order is considered to be singular; thus, rendering the response determination of such systems in a straightforward manner a difficult task. In this regard, the notion of the generalized inverse of a singular matrix is used for determining response statistics. Further, an application relevant to engineering dynamics problems is included.

  16. Evidence for the distortion product frequency place as a source of distortion product otoacoustic emission (DPOAE) fine structure in humans. I. Fine structure and higher-order DPOAE as a function of the frequency ratio f2/f1.

    PubMed

    Mauermann, M; Uppenkamp, S; van Hengel, P W; Kollmeier, B

    1999-12-01

    Critical experiments were performed in order to validate the two-source hypothesis of distortion product otoacoustic emissions (DPOAE) generation. Measurements of the spectral fine structure of DPOAE in response to stimulation with two sinusoids have been performed with normal-hearing subjects. The dependence of fine-structure patterns on the frequency ratio f2/f1 was investigated by changing f1 or f2 only (fixed f2 or fixed f1 paradigm, respectively), and by changing both primaries at a fixed ratio and looking at different order DPOAE. When f2/f1 is varied in the fixed ratio paradigm, the patterns of 2 f1-f2 fine structure vary considerably more if plotted as a function of f2 than as a function of fDP. Different order distortion products located at the same characteristic place on the basilar membrane (BM) show similar patterns for both, the fixed-f2 and fDP paradigms. Fluctuations in DPOAE level up to 20 dB can be observed. In contrast, the results from a fixed-fDP paradigm do not show any fine structure but only an overall dependence of DP level on the frequency ratio, with a maximum for 2f1-f2 at f2/f1 close to 1.2. Similar stimulus configurations used in the experiments have also been used for computer simulations of DPOAE in a nonlinear and active model of the cochlea. Experimental results and model simulations give strong evidence for a two-source model of DPOAE generation: The first source is the initial nonlinear interaction of the primaries close to the f2 place. The second source is caused by coherent reflection from a re-emission site at the characteristic place of the distortion product frequency. The spectral fine structure of DPOAE observed in the ear canal reflects the interaction of both these sources. PMID:10615687

  17. Prominent Higher-Order Contributions to Electronic Recombination

    SciTech Connect

    Beilmann, C.; Mokler, P. H.; Bernitt, S.; Keitel, C. H.; Ullrich, J.; Lopez-Urrutia, J. R. Crespo; Harman, Z.

    2011-09-30

    Intershell higher-order (HO) electronic recombination is reported for highly charged Ar, Fe, and Kr ions, where simultaneous excitation of one K-shell electron and one or two additional L-shell electrons occurs upon resonant capture of a free electron. For the mid-Z region, HO resonance strengths grow unexpectedly strong with decreasing atomic number Z ({proportional_to}Z{sup -4}), such that, for Ar ions the 2nd-order overwhelms the 1st-order resonant recombination considerably. The experimental findings are confirmed by multiconfiguration Dirac-Fock calculations including hitherto neglected excitation pathways.

  18. Higher-order dynamical effects in Coulomb dissociation

    SciTech Connect

    Esbensen, H.; Bertsch, G.F.; Bertulani, C.A.

    1995-08-01

    Coulomb dissociation is a technique commonly used to extract the dipole response of nuclei far from stability. This technique is applicable if the dissociation is dominated by dipole transitions and if first-order perturbation theory is valid. In order to assess the significance of higher-order processes we solve numerically the time evolution of the wave function for a two-body breakup in the Coulomb field from a high Z target. We applied this method to the breakup reactions: {sup 11}Be {yields} {sup 10}Be + n and {sup 11}Li {yields} +2n. The latter is treated as a two-body breakup, using a di-neutron model.

  19. Using Higher Order Computer Tasks with Disadvantaged Students.

    ERIC Educational Resources Information Center

    Anderson, Neil

    A pilot program initially designed for a 12-year-old girl with mild to moderate intellectual disabilities in higher order computer tasks was developed for a larger group of students with similar disabilities enrolled in fifth and sixth grades (ages 9-12) at three different schools. An examination of the original pilot study was undertaken to…

  20. Higher-Order Latent Trait Models for Cognitive Diagnosis

    ERIC Educational Resources Information Center

    de la Torre, Jimmy; Douglas, Jeffrey A.

    2004-01-01

    Higher-order latent traits are proposed for specifying the joint distribution of binary attributes in models for cognitive diagnosis. This approach results in a parsimonious model for the joint distribution of a high-dimensional attribute vector that is natural in many situations when specific cognitive information is sought but a less informative…

  1. Constrained variational calculus for higher order classical field theories

    NASA Astrophysics Data System (ADS)

    Campos, Cédric M.; de León, Manuel; Martín de Diego, David

    2010-11-01

    We develop an intrinsic geometrical setting for higher order constrained field theories. As a main tool we use an appropriate generalization of the classical Skinner-Rusk formalism. Some examples of applications are studied, in particular to the geometrical description of optimal control theory for partial differential equations.

  2. Higher order microfibre modes for dielectric particle trapping and propulsion.

    PubMed

    Maimaiti, Aili; Truong, Viet Giang; Sergides, Marios; Gusachenko, Ivan; Nic Chormaic, Síle

    2015-01-01

    Optical manipulation in the vicinity of optical micro- and nanofibres has shown potential across several fields in recent years, including microparticle control, and cold atom probing and trapping. To date, most work has focussed on the propagation of the fundamental mode through the fibre. However, along the maximum mode intensity axis, higher order modes have a longer evanescent field extension and larger field amplitude at the fibre waist compared to the fundamental mode, opening up new possibilities for optical manipulation and particle trapping. We demonstrate a microfibre/optical tweezers compact system for trapping and propelling dielectric particles based on the excitation of the first group of higher order modes at the fibre waist. Speed enhancement of polystyrene particle propulsion was observed for the higher order modes compared to the fundamental mode for particles ranging from 1 μm to 5 μm in diameter. The optical propelling velocity of a single, 3 μm polystyrene particle was found to be 8 times faster under the higher order mode than the fundamental mode field for a waist power of 25 mW. Experimental data are supported by theoretical calculations. This work can be extended to trapping and manipulation of laser-cooled atoms with potential for quantum networks. PMID:25766925

  3. Building Higher-Order Markov Chain Models with EXCEL

    ERIC Educational Resources Information Center

    Ching, Wai-Ki; Fung, Eric S.; Ng, Michael K.

    2004-01-01

    Categorical data sequences occur in many applications such as forecasting, data mining and bioinformatics. In this note, we present higher-order Markov chain models for modelling categorical data sequences with an efficient algorithm for solving the model parameters. The algorithm can be implemented easily in a Microsoft EXCEL worksheet. We give a…

  4. Higher Order Language Competence and Adolescent Mental Health

    ERIC Educational Resources Information Center

    Cohen, Nancy J.; Farnia, Fataneh; Im-Bolter, Nancie

    2013-01-01

    Background: Clinic and community-based epidemiological studies have shown an association between child psychopathology and language impairment. The demands on language for social and academic adjustment shift dramatically during adolescence and the ability to understand the nonliteral meaning in language represented by higher order language…

  5. Computer-Mediated Assessment of Higher-Order Thinking Development

    ERIC Educational Resources Information Center

    Tilchin, Oleg; Raiyn, Jamal

    2015-01-01

    Solving complicated problems in a contemporary knowledge-based society requires higher-order thinking (HOT). The most productive way to encourage development of HOT in students is through use of the Problem-based Learning (PBL) model. This model organizes learning by solving corresponding problems relative to study courses. Students are directed…

  6. Using Higher-Order Skills in American History.

    ERIC Educational Resources Information Center

    Litogot, Sandra A.

    1991-01-01

    Provides a six-part lesson plan for use in secondary U.S. history classes. Illustrates the development of higher-order reading, writing, and thinking skills in assignments and projects dealing with the history of westward expansion. Specific skills addressed are comparison, contrast, prediction, and evaluation. Recommends cooperative learning…

  7. Using Database Projects To Promote Higher-Order Thinking Skills.

    ERIC Educational Resources Information Center

    Lytle, Cora

    1999-01-01

    Explains how the process of creating a database provides opportunities for business instructors to use teaching strategies that promote higher-order thinking skills. Describes a project at a school of business in which each student must build an original database and apply functions of tables, queries, forms, and reports. (JOW)

  8. Higher order microfibre modes for dielectric particle trapping and propulsion

    PubMed Central

    Maimaiti, Aili; Truong, Viet Giang; Sergides, Marios; Gusachenko, Ivan; Nic Chormaic, Síle

    2015-01-01

    Optical manipulation in the vicinity of optical micro- and nanofibres has shown potential across several fields in recent years, including microparticle control, and cold atom probing and trapping. To date, most work has focussed on the propagation of the fundamental mode through the fibre. However, along the maximum mode intensity axis, higher order modes have a longer evanescent field extension and larger field amplitude at the fibre waist compared to the fundamental mode, opening up new possibilities for optical manipulation and particle trapping. We demonstrate a microfibre/optical tweezers compact system for trapping and propelling dielectric particles based on the excitation of the first group of higher order modes at the fibre waist. Speed enhancement of polystyrene particle propulsion was observed for the higher order modes compared to the fundamental mode for particles ranging from 1 μm to 5 μm in diameter. The optical propelling velocity of a single, 3 μm polystyrene particle was found to be 8 times faster under the higher order mode than the fundamental mode field for a waist power of 25 mW. Experimental data are supported by theoretical calculations. This work can be extended to trapping and manipulation of laser-cooled atoms with potential for quantum networks. PMID:25766925

  9. Assessing the Influence of Portfolios on Higher Order Thinking Skills.

    ERIC Educational Resources Information Center

    Seiter, David M.

    How the use of portfolios in the classroom will influence the higher order thinking skills is the main focus of this project. The introduction of portfolios as assessment tools is rather new to educational research, but does offer a legitimate area for serious study. Portfolios when used by students can offer them not only a way to showcase their…

  10. Multiple-Try Feedback and Higher-Order Learning Outcomes

    ERIC Educational Resources Information Center

    Clariana, Roy B.; Koul, Ravinder

    2005-01-01

    Although feedback is an important component of computer-based instruction (CBI), the effects of feedback on higher-order learning outcomes are not well understood. Several meta-analyses provide two rules of thumb: any feedback is better than no feedback and feedback with more information is better than feedback with less information. …

  11. Developing Higher-Order Thinking Skills through WebQuests

    ERIC Educational Resources Information Center

    Polly, Drew; Ausband, Leigh

    2009-01-01

    In this study, 32 teachers participated in a year-long professional development project related to technology integration in which they designed and implemented a WebQuest. This paper describes the extent to which higher-order thinking skills (HOTS) and levels of technology implementation (LoTI) occur in the WebQuests that participants designed.…

  12. Higher-order ionospheric error at Arecibo, Millstone, and Jicamarca

    NASA Astrophysics Data System (ADS)

    Matteo, N. A.; Morton, Y. T.

    2010-12-01

    The ionosphere is a dominant source of Global Positioning System receiver range measurement error. Although dual-frequency receivers can eliminate the first-order ionospheric error, most second- and third-order errors remain in the range measurements. Higher-order ionospheric error is a function of both electron density distribution and the magnetic field vector along the GPS signal propagation path. This paper expands previous efforts by combining incoherent scatter radar (ISR) electron density measurements, the International Reference Ionosphere model, exponential decay extensions of electron densities, the International Geomagnetic Reference Field, and total electron content maps to compute higher-order error at ISRs in Arecibo, Puerto Rico; Jicamarca, Peru; and Millstone Hill, Massachusetts. Diurnal patterns, dependency on signal direction, seasonal variation, and geomagnetic activity dependency are analyzed. Higher-order error is largest at Arecibo with code phase maxima circa 7 cm for low-elevation southern signals. The maximum variation of the error over all angles of arrival is circa 8 cm.

  13. Speckle reduction via higher order total variation approach.

    PubMed

    Wensen Feng; Hong Lei; Yang Gao

    2014-04-01

    Multiplicative noise (also known as speckle) reduction is a prerequisite for many image-processing tasks in coherent imaging systems, such as the synthetic aperture radar. One approach extensively used in this area is based on total variation (TV) regularization, which can recover significantly sharp edges of an image, but suffers from the staircase-like artifacts. In order to overcome the undesirable deficiency, we propose two novel models for removing multiplicative noise based on total generalized variation (TGV) penalty. The TGV regularization has been mathematically proven to be able to eliminate the staircasing artifacts by being aware of higher order smoothness. Furthermore, an efficient algorithm is developed for solving the TGV-based optimization problems. Numerical experiments demonstrate that our proposed methods achieve state-of-the-art results, both visually and quantitatively. In particular, when the image has some higher order smoothness, our methods outperform the TV-based algorithms. PMID:24808350

  14. Higher-Order Spectrum in Understanding Nonlinearity in EEG Rhythms

    PubMed Central

    Pradhan, Cauchy; Jena, Susant K.; Nadar, Sreenivasan R.; Pradhan, N.

    2012-01-01

    The fundamental nature of the brain's electrical activities recorded as electroencephalogram (EEG) remains unknown. Linear stochastic models and spectral estimates are the most common methods for the analysis of EEG because of their robustness, simplicity of interpretation, and apparent association with rhythmic behavioral patterns in nature. In this paper, we extend the use of higher-order spectrum in order to indicate the hidden characteristics of EEG signals that simply do not arise from random processes. The higher-order spectrum is an extension Fourier spectrum that uses higher moments for spectral estimates. This essentially nullifies all Gaussian random effects, therefore, can reveal non-Gaussian and nonlinear characteristics in the complex patterns of EEG time series. The paper demonstrates the distinguishing features of bispectral analysis for chaotic systems, filtered noises, and normal background EEG activity. The bispectrum analysis detects nonlinear interactions; however, it does not quantify the coupling strength. The squared bicoherence in the nonredundant region has been estimated to demonstrate nonlinear coupling. The bicoherence values are minimal for white Gaussian noises (WGNs) and filtered noises. Higher bicoherence values in chaotic time series and normal background EEG activities are indicative of nonlinear coupling in these systems. The paper shows utility of bispectral methods as an analytical tool in understanding neural process underlying human EEG patterns. PMID:22400046

  15. Higher order corrections in minimal supergravity models of inflation

    SciTech Connect

    Ferrara, Sergio; Kallosh, Renata; Linde, Andrei; Porrati, Massimo E-mail: kallosh@stanford.edu E-mail: massimo.porrati@nyu.edu

    2013-11-01

    We study higher order corrections in new minimal supergravity models of a single scalar field inflation. The gauging in these models leads to a massive vector multiplet and the D-term potential for the inflaton field with a coupling g{sup 2} ∼ 10{sup −10}. In the de-Higgsed phase with vanishing g{sup 2}, the chiral and vector multiplets are non-interacting, and the potential vanishes. We present generic manifestly supersymmetric higher order corrections for these models. In particular, for a supersymmetric gravity model −R+R{sup 2} we derive manifestly supersymmetric corrections corresponding to R{sup n}. The dual version corresponds to a standard supergravity model with a single scalar and a massive vector. It includes, in addition, higher Maxwell curvature/scalar interaction terms of the Born-Infeld type and a modified D-term scalar field potential. We use the dual version of the model to argue that higher order corrections do not affect the last 60 e-foldings of inflation; for example the ξR{sup 4} correction is irrelevant as long as ξ < 10{sup 24}.

  16. Synchronous firing and higher-order interactions in neuron pool.

    PubMed

    Amari, Shun-Ichi; Nakahara, Hiroyuki; Wu, Si; Sakai, Yutaka

    2003-01-01

    The stochastic mechanism of synchronous firing in a population of neurons is studied from the point of view of information geometry. Higher-order interactions of neurons, which cannot be reduced to pairwise correlations, are proved to exist in synchronous firing. In a neuron pool where each neuron fires stochastically, the probability distribution q(r) of the activity r, which is the fraction of firing neurons in the pool, is studied. When q(r) has a widespread distribution, in particular, when q(r) has two peaks, the neurons fire synchronously at one time and are quiescent at other times. The mechanism of generating such a probability distribution is interesting because the activity r is concentrated on its mean value when each neuron fires independently, because of the law of large numbers. Even when pairwise interactions, or third-order interactions, exist, the concentration is not resolved. This shows that higher-order interactions are necessary to generate widespread activity distributions. We analyze a simple model in which neurons receive common overlapping inputs and prove that such a model can have a widespread distribution of activity, generating higher-order stochastic interactions. PMID:12590822

  17. Higher order correlation beams in atmosphere under strong turbulence conditions.

    PubMed

    Avetisyan, H; Monken, C H

    2016-02-01

    Higher order correlation beams, that is, two-photon beams obtained from the process of spontaneous parametric down-conversion pumped by Hermite-Gauss or Laguerre-Gauss beams of any order, can be used to encode information in many modes, opening the possibility of quantum communication with large alphabets. In this paper we calculate, analytically, the fourth-order correlation function for the Hermite-Gauss and Laguerre-Gauss coherent and partially coherent correlation beams propagating through a strong turbulent medium. We show that fourth-order correlation functions for correlation beams have, under certain conditions, expressions similar to those of intensities of classical beams and are degraded by turbulence in a similar way as the classical beams. Our results can be useful in establishing limits for the use of two-photon beams in quantum communications with larger alphabets under atmospheric turbulence. PMID:26906808

  18. Lipkin method of particle-number restoration to higher orders

    NASA Astrophysics Data System (ADS)

    Wang, X. B.; Dobaczewski, J.; Kortelainen, M.; Yu, L. F.; Stoitsov, M. V.

    2014-07-01

    Background: On the mean-field level, pairing correlations are incorporated through the Bogoliubov-Valatin transformation, whereby the particle degrees of freedom are replaced by quasiparticles. This approach leads to a spontaneous breaking of the particle-number symmetry and mixing of states with different particle numbers. In order to restore the particle number, various methods have been employed, which are based on projection approaches before or after variation. Approximate variation-after-projection (VAP) schemes, utilizing the Lipkin method, have mostly been used within the Lipkin-Nogami prescription. Purpose: Without employing the Lipkin-Nogami prescription, and using, instead, states rotated in the gauge space, we derive the Lipkin method of particle-number restoration up to sixth order and we test the convergence and accuracy of the obtained expansion. Methods: We perform self-consistent calculations using the higher-order Lipkin method to restore the particle-number symmetry in the framework of superfluid nuclear energy-density functional theory. We also apply the Lipkin method to a schematic exactly solvable two-level pairing model. Results: Calculations performed in open-shell tin and lead isotopes show that the Lipkin method converges at fourth order and satisfactorily reproduces the VAP ground-state energies and energy kernels. Near closed shells, the higher-order Lipkin method cannot be applied because of a nonanalytic kink in the ground-state energies as a function of the particle number. Conclusions: In open-shell nuclei, the higher-order Lipkin method provides a good approximation to the exact VAP energies. The method is computationally inexpensive, making it particularly suitable, for example, for future optimizations of the nuclear energy density functionals and simultaneous restoration of different symmetries.

  19. A Short Note on Rules and Higher Order Rules.

    ERIC Educational Resources Information Center

    Scandura, Joseph M.

    This brief paper argues that structural analysis--an extended form of cognitive task analysis--demonstrates that both domain dependent and domain independent knowledge can be derived from specific content domains. It is noted that the major difference between the two is that lower order rules (specific knowledge) are derived directly from specific…

  20. Sandia Higher Order Elements (SHOE) v 0.5 alpha

    SciTech Connect

    2013-09-24

    SHOE is research code for characterizing and visualizing higher-order finite elements; it contains a framework for defining classes of interpolation techniques and element shapes; methods for interpolating triangular, quadrilateral, tetrahedral, and hexahedral cells using Lagrange and Legendre polynomial bases of arbitrary order; methods to decompose each element into domains of constant gradient flow (using a polynomial solver to identify critical points); and an isocontouring technique that uses this decomposition to guarantee topological correctness. Please note that this is an alpha release of research software and that some time has passed since it was actively developed; build- and run-time issues likely exist.

  1. A higher order theory of laminated composite cylindrical shells

    NASA Technical Reports Server (NTRS)

    Krishna Murthy, A. V.; Reddy, T. S. R.

    1986-01-01

    A new higher order theory has been proposed for the analysis of composite cylindrical shells. The formulation allows for arbitrary variation of inplane displacements. Governing equations are presented in the form of a hierarchy of sets of partial differential equations. Each set describes the shell behavior to a certain degree of approximation. The natural frequencies of simply-supported isotropic and laminated shells and stresses in a ring loaded composite shell have been determined to various orders of approximation and compared with three dimensional solutions. These numerical studies indicate the improvements achievable in estimating the natural frequencies and the interlaminar shear stresses in laminated composite cylinders.

  2. Analytical formulas for gravitational lensing: Higher order calculation

    SciTech Connect

    Amore, Paolo; Arceo, Santiago; Fernandez, Francisco M.

    2006-10-15

    We extend to higher order a recently published method for calculating the deflection angle of light in a general static and spherically symmetric metric. We have tested our method on the metric of Schwarzschild and Reissner-Nordstroem black holes, on the metric of a charged black hole coupled to Born-Infeld electrodynamics and on the metric of Weyl gravity. Since our method is geometrically convergent, as proved in our previous work, our analytical formulas obtained working to fourth order are sufficient to reach errors of few percents even in proximity of the photon sphere.

  3. Sandia Higher Order Elements (SHOE) v 0.5 alpha

    Energy Science and Technology Software Center (ESTSC)

    2013-09-24

    SHOE is research code for characterizing and visualizing higher-order finite elements; it contains a framework for defining classes of interpolation techniques and element shapes; methods for interpolating triangular, quadrilateral, tetrahedral, and hexahedral cells using Lagrange and Legendre polynomial bases of arbitrary order; methods to decompose each element into domains of constant gradient flow (using a polynomial solver to identify critical points); and an isocontouring technique that uses this decomposition to guarantee topological correctness. Please notemore » that this is an alpha release of research software and that some time has passed since it was actively developed; build- and run-time issues likely exist.« less

  4. Algorithmic and Experimental Computation of Higher-Order Safe Primes

    NASA Astrophysics Data System (ADS)

    Díaz, R. Durán; Masqué, J. Muñoz

    2008-09-01

    This paper deals with a class of special primes called safe primes. In the regular definition, an odd prime p is safe if, at least, one of (p±1)/2 is prime. Safe primes have been recommended as factors of RSA moduli. In this paper, the concept of safe primes is extended to higher-order safe primes, and an explicit formula to compute the density of this class of primes in the set of the integers is supplied. Finally, explicit conditions are provided permitting the algorithmic computation of safe primes of arbitrary order. Some experimental results are provided as well.

  5. High Precision Superconducting Cavity Diagnostics With Higher Order Mode Measurements

    SciTech Connect

    Molloy, S.; Frisch, J.; McCormick, D.; May, J.; Ross, M.; Smith, T.; Baboi, N.; Hensler, O.; Petrosian, L.; Napoly, O.; Paparella, R.C.; Simon, C.; Eddy, N.; Nagaitsev, S.; Wendt, M.; /Fermilab

    2007-02-12

    Experiments at the FLASH facility at DESY have demonstrated that the higher order modes induced in superconducting cavities can be used to provide a variety of beam and cavity diagnostics. The axes of the modes can be determined from the beam orbit that produces minimum power in the dipole HOM modes. The phase and amplitude of the dipole modes can be used to obtain high resolution beam position information, and the phase of the monopole modes to measure the beam phase relative to the accelerator rf. For most superconducting accelerators, the existing higher order mode couplers provide the necessary signals, and the downmix and digitizing electronics are straightforward, similar to those for a conventional beam position monitor.

  6. Stabilization with target oriented control for higher order difference equations

    NASA Astrophysics Data System (ADS)

    Braverman, Elena; Franco, Daniel

    2015-06-01

    For a physical or biological model whose dynamics is described by a higher order difference equation un+1 = f (un ,un-1 , … ,u n - k + 1), we propose a version of a target oriented control un+1 = cT + (1 - c) f (un ,un-1 , … ,u n - k + 1), with T ≥ 0, c ∈ [ 0 , 1). In ecological systems, the method incorporates harvesting and recruitment and for a wide class of f, allows to stabilize (locally or globally) a fixed point of f. If a point which is not a fixed point of f has to be stabilized, the target oriented control is an appropriate method for achieving this goal. As a particular case, we consider pest control applied to pest populations with delayed density-dependence. This corresponds to a proportional feedback method, which includes harvesting only, for higher order equations.

  7. Spatial complexity of solutions of higher order partial differential equations

    NASA Astrophysics Data System (ADS)

    Kukavica, Igor

    2004-03-01

    We address spatial oscillation properties of solutions of higher order parabolic partial differential equations. In the case of the Kuramoto-Sivashinsky equation ut + uxxxx + uxx + u ux = 0, we prove that for solutions u on the global attractor, the quantity card {x epsi [0, L]:u(x, t) = lgr}, where L > 0 is the spatial period, can be bounded by a polynomial function of L for all \\lambda\\in{\\Bbb R} . A similar property is proven for a general higher order partial differential equation u_t+(-1)^{s}\\partial_x^{2s}u+ \\sum_{k=0}^{2s-1}v_k(x,t)\\partial_x^k u =0 .

  8. Higher order mode excitations in gyro-amplifiers

    NASA Astrophysics Data System (ADS)

    Nguyen, K. T.; Calame, J. P.; Danly, B. G.; Levush, B.; Garven, M.; Antonsen, T.

    2001-05-01

    In gyro-devices, a nonlinear output taper is often employed as the transition from the near cutoff radius of the interaction circuit to a much larger output waveguide. The tapers are usually designed to avoid passive mode conversion, and thus do not consider the effect of a bunched beam. However, recent simulations with the self-consistent MAGY code [Botton et al., IEEE Trans. Plasma Sci. 26, 882 (1998)] indicate that higher order mode interactions with the bunched electron beam can substantially compromise the mode purity of the rf output. The interaction in the taper region is traveling wave in nature, and is strongly dependent on the residual beam bunching characteristics resulting from the upstream operating mode interaction. An experiment has been performed to quantify the rf output mode content from a Ka-band gyroklystron. The agreement between salient theoretical and measured rf output characteristics confirms the existence of higher order mode excitation in output tapers as predicted by theory.

  9. Promoting higher order thinking skills using inquiry-based learning

    NASA Astrophysics Data System (ADS)

    Madhuri, G. V.; S. S. N Kantamreddi, V.; Goteti, L. N. S. Prakash

    2012-05-01

    Active learning pedagogies play an important role in enhancing higher order cognitive skills among the student community. In this work, a laboratory course for first year engineering chemistry is designed and executed using an inquiry-based learning pedagogical approach. The goal of this module is to promote higher order thinking skills in chemistry. Laboratory exercises are designed based on Bloom's taxonomy and a just-in-time facilitation approach is used. A pre-laboratory discussion outlining the theory of the experiment and its relevance is carried out to enable the students to analyse real-life problems. The performance of the students is assessed based on their ability to perform the experiment, design new experiments and correlate practical utility of the course module with real life. The novelty of the present approach lies in the fact that the learning outcomes of the existing experiments are achieved through establishing a relationship with real-world problems.

  10. Higher-order effects in inclusive electron-nucleus scattering.

    SciTech Connect

    Benhar, O.; Fabrocini, A.; Fantoni, S.; Pandharipande, V. R.; Pieper, S. C.; Sick, I.; Physics; INFIN; Univ. of Pisa; SISSA; Univ. of Illinois; SISSA; Univ. Basel

    1995-10-05

    Higher order corrections in the theory of inclusive scattering of high energy electrons by nuclear matter are studied. They involve at least three nucleons, and are due to: (i) the correlations among the spectator nucleons in matter, and (ii) the Pauli blocking of the scattering of the struck nucleon by a spectator nucleon. Their effect on the cross sections is found to be much smaller than those of the two-nucleon correlation hole and of color transparency.

  11. Validating variational principle for higher order theory of gravity

    NASA Astrophysics Data System (ADS)

    Ruz, Soumendranath; Sarkar, Kaushik; Sk, Nayem; Sanyal, Abhik Kumar

    2015-06-01

    Metric variation of higher order theory of gravity requires fixing of the Ricci scalar in addition to the metric tensor at the boundary. Fixing Ricci scalar at the boundary implies that the classical solutions are fixed once and forever to the de Sitter or anti-de Sitter (dS/AdS) solutions. Here, we justify such requirement from the standpoint of Noether symmetry.

  12. A higher-order Robert-Asselin type time filter

    NASA Astrophysics Data System (ADS)

    Li, Yong; Trenchea, Catalin

    2014-02-01

    The Robert-Asselin (RA) time filter combined with leapfrog scheme is widely used in numerical models of weather and climate. It successfully suppresses the spurious computational mode associated with the leapfrog method, but it also weakly dampens the physical mode and degrades the numerical accuracy. The Robert-Asselin-Williams (RAW) time filter is a modification of the RA filter that reduces the undesired numerical damping of RA filter and increases the accuracy. We propose a higher-order Robert-Asselin (hoRA) type time filter which effectively suppresses the computational modes and achieves third-order accuracy with the same storage requirement as RAW filter. Like RA and RAW filters, the hoRA filter is non-intrusive, and so it would be easily implementable. The leapfrog scheme with hoRA filter is almost as accurate, stable and efficient as the intrusive third-order Adams-Bashforth (AB3) method.

  13. Higher-order nonlinear effects in a Josephson parametric amplifier

    NASA Astrophysics Data System (ADS)

    Kochetov, Bogdan A.; Fedorov, Arkady

    2015-12-01

    Nonlinearity of the current-phase relationship of a Josephson junction is the key resource for a Josephson parametric amplifier (JPA) as well as for a Josephson traveling-wave parametric amplifier, the only devices in which the quantum limit for added noise has so far been approached at microwave frequencies. A standard approach to describe JPA takes into account only the lowest order (cubic) nonlinearity resulting in a Duffing-like oscillator equation of motion or in a Kerr-type nonlinearity term in the Hamiltonian. In this paper we derive the quantum expression for the gain of JPA including all orders of the Josephson junction nonlinearity in the linear response regime. We then analyze gain saturation effect for stronger signals within a semiclassical approach. Our results reveal nonlinear effects of higher orders and their implications for operation of a JPA.

  14. Higher-order ionosphere modeling for CODE's next reprocessing activities

    NASA Astrophysics Data System (ADS)

    Lutz, S.; Schaer, S.; Meindl, M.; Dach, R.; Steigenberger, P.

    2009-12-01

    CODE (the Center for Orbit Determination in Europe) is a joint venture between the Astronomical Institute of the University of Bern (AIUB, Bern, Switzerland), the Federal Office of Topography (swisstopo, Wabern, Switzerland), the Federal Agency for Cartography and Geodesy (BKG, Frankfurt am Main, Germany), and the Institut für Astronomische und Phsyikalische Geodäsie of the Technische Universität München (IAPG/TUM, Munich, Germany). It acts as one of the global analysis centers of the International GNSS Service (IGS) and participates in the first IGS reprocessing campaign, a full reanalysis of GPS data collected since 1994. For a future reanalyis of the IGS data it is planned to consider not only first-order but also higher-order ionosphere terms in the space geodetic observations. There are several works (e.g. Fritsche et al. 2005), which showed a significant and systematic influence of these effects on the analysis results. The development version of the Bernese Software used at CODE is expanded by the ability to assign additional (scaling) parameters to each considered higher-order ionosphere term. By this, each correction term can be switched on and off on normal-equation level and, moreover, the significance of each correction term may be verified on observation level for different ionosphere conditions.

  15. Orchestration of Molecular Information through Higher Order Chemical Recognition

    NASA Astrophysics Data System (ADS)

    Frezza, Brian M.

    Broadly defined, higher order chemical recognition is the process whereby discrete chemical building blocks capable of specifically binding to cognate moieties are covalently linked into oligomeric chains. These chains, or sequences, are then able to recognize and bind to their cognate sequences with a high degree of cooperativity. Principally speaking, DNA and RNA are the most readily obtained examples of this chemical phenomenon, and function via Watson-Crick cognate pairing: guanine pairs with cytosine and adenine with thymine (DNA) or uracil (RNA), in an anti-parallel manner. While the theoretical principles, techniques, and equations derived herein apply generally to any higher-order chemical recognition system, in practice we utilize DNA oligomers as a model-building material to experimentally investigate and validate our hypotheses. Historically, general purpose information processing has been a task limited to semiconductor electronics. Molecular computing on the other hand has been limited to ad hoc approaches designed to solve highly specific and unique computation problems, often involving components or techniques that cannot be applied generally in a manner suitable for precise and predictable engineering. Herein, we provide a fundamental framework for harnessing high-order recognition in a modular and programmable fashion to synthesize molecular information process networks of arbitrary construction and complexity. This document provides a solid foundation for routinely embedding computational capability into chemical and biological systems where semiconductor electronics are unsuitable for practical application.

  16. Polymer quantization, stability and higher-order time derivative terms

    NASA Astrophysics Data System (ADS)

    Cumsille, Patricio; Reyes, Carlos M.; Ossandon, Sebastian; Reyes, Camilo

    2016-03-01

    The possibility that fundamental discreteness implicit in a quantum gravity theory may act as a natural regulator for ultraviolet singularities arising in quantum field theory has been intensively studied. Here, along the same expectations, we investigate whether a nonstandard representation called polymer representation can smooth away the large amount of negative energy that afflicts the Hamiltonians of higher-order time derivative theories, rendering the theory unstable when interactions come into play. We focus on the fourth-order Pais-Uhlenbeck model which can be reexpressed as the sum of two decoupled harmonic oscillators one producing positive energy and the other negative energy. As expected, the Schrödinger quantization of such model leads to the stability problem or to negative norm states called ghosts. Within the framework of polymer quantization we show the existence of new regions where the Hamiltonian can be defined well bounded from below.

  17. Higher order mode damping in an ALS test cavity

    SciTech Connect

    Jacob, A.F.; Lamberston, G.R. ); Barry, W. )

    1990-06-01

    The higher order mode attenuation scheme proposed for the Advanced Light Source accelerating cavities consists of two broad-band dampers placed 90{degrees} apart on the outer edge. In order to assess the damping efficiency a test assembly was built. The HOM damping was obtained by comparing the peak values of the transmission through the cavity for both the damped and the undamped case. Because of the high number of modes and frequency shifts due to the damping gear, the damping was assessed statistically, by averaging over several modes. In the frequency range from 1.5 to 5.5 GHz, average damping greater than 100 was obtained. 1 ref., 6 figs.

  18. Higher-order automatic differentiation of mathematical functions

    NASA Astrophysics Data System (ADS)

    Charpentier, Isabelle; Dal Cappello, Claude

    2015-04-01

    Functions of mathematical physics such as the Bessel functions, the Chebyshev polynomials, the Gauss hypergeometric function and so forth, have practical applications in many scientific domains. On the one hand, differentiation formulas provided in reference books apply to real or complex variables. These do not account for the chain rule. On the other hand, based on the chain rule, the automatic differentiation has become a natural tool in numerical modeling. Nevertheless automatic differentiation tools do not deal with the numerous mathematical functions. This paper describes formulas and provides codes for the higher-order automatic differentiation of mathematical functions. The first method is based on Faà di Bruno's formula that generalizes the chain rule. The second one makes use of the second order differential equation they satisfy. Both methods are exemplified with the aforementioned functions.

  19. Higher order software - A methodology for defining software

    NASA Technical Reports Server (NTRS)

    Hamilton, M.; Zeldin, S.

    1976-01-01

    Higher order software (HOS) is concerned only with computable functions and relationships. The HOS methodology can be used for the definition of software for multiprogrammed, multiprocessor, or multicomputer systems. A description of HOS methodology is presented, giving attention to questions of formulation, interface correctness, specification language principles, and HOS analyzers. Aspects of system design are considered, and details of software management are discussed. Attention is given to modularity as defined by HOS, frozen module management, the assembly control supervisor, and aspects of reliability and efficiency.

  20. High Precision SC Cavity alignment Measurements with Higher Order Modes

    SciTech Connect

    Molloy, Stephen; Frisch, Josef; Hendrickson, Linda; McCormick, Douglas; May, Justin; Ross, Marc; Smith, Tonee; Eddy, Nathan; Nagaitsev, Sergei; Baboi, Nicoleta; Hensler, Olaf; Petrosyan, Lyudvig; Napoly, Olivier; Paparella, Rita; Simon, Claire; /DSM, DAPNIA, Saclay

    2007-06-14

    Experiments at the FLASH linac at DESY have demonstrated that the higher order modes (HOMs) induced in superconducting cavities can be used to provide a variety of beam and cavity diagnostics. The centers of the cavities can be determined from the beam orbit which produces minimum power in the dipole HOM modes. The phase and amplitude of the dipole modes can be used as a high resolution beam position monitor. For most superconducting accelerators, the existing HOM couplers provide the necessary signals, and the downmix and digitizing electronics are straightforward, similar to those for a conventional BPM.

  1. Tight focusing of higher orders Laguerre-Gaussian modes

    NASA Astrophysics Data System (ADS)

    Savelyev, Dmitry A.; Khonina, Svetlana N.; Golub, Ilya

    2016-04-01

    The spatial redistribution of the contribution of different electric field components provides a decrease in the size of the central focal spot for higher orders Laguerre-Gaussian modes. It was shown that when sharply focusing laser beams with vortex or special binary phase plate, a sub-wavelength light localization of separate vector field components is possible for any polarization type. This fact should be considered for the interaction of laser radiation with materials selectively sensitive to lateral and longitudinal components of the electromagnetic field.

  2. Higher Order Mode Properties of Superconducting Two-Spoke Cavities

    SciTech Connect

    Hopper, C. S.; Delayen, J. R.; Olave, R. G.

    2011-07-01

    Multi-Spoke cavities lack the cylindrical symmetry that many other cavity types have, which leads to a more complex Higher Order Mode (HOM) spectrum. In addition, spoke cavities offer a large velocity acceptance which means we must perform a detailed analysis of the particle velocity dependence for each mode's R/Q. We present here a study of the HOM properties of two-spoke cavities designed for high-velocity applications. Frequencies, R/Q and field profiles of HOMs have been calculated and are reported.

  3. Higher-order laser mode converters with dielectric metasurfaces.

    PubMed

    He, Yongli; Liu, Zhenxing; Liu, Yachao; Zhou, Junxiao; Ke, Yougang; Luo, Hailu; Wen, Shuangchun

    2015-12-01

    A simple and compact converter based on the dielectric metasurface is proposed for the transformation of Gaussian mode to Hermite-Gaussian and Laguerre-Gaussian modes. We establish the relationship between the phase of a desired mode and the local orientation of the optical axis based on the evolution of Pancharatnam-Berry phase on Poincaré sphere. By controlling the local orientation of the optical axis in the dielectric metasurface, we can achieve any desired higher-order laser mode. PMID:26625037

  4. Programming real-time executives in higher order language

    NASA Technical Reports Server (NTRS)

    Foudriat, E. C.

    1982-01-01

    Methods by which real-time executive programs can be implemented in a higher order language are discussed, using HAL/S and Path Pascal languages as program examples. Techniques are presented by which noncyclic tasks can readily be incorporated into the executive system. Situations are shown where the executive system can fail to meet its task scheduling and yet be able to recover either by rephasing the clock or stacking the information for later processing. The concept of deadline processing is shown to enable more effective mixing of time and information synchronized systems.

  5. Measurement of distributed strain and temperature based on higher order and higher mode Bragg conditions

    NASA Technical Reports Server (NTRS)

    Sirkis, James S. (Inventor); Sivanesan, Ponniah (Inventor); Venkat, Venki S. (Inventor)

    2001-01-01

    A Bragg grating sensor for measuring distributed strain and temperature at the same time comprises an optical fiber having a single mode operating wavelength region and below a cutoff wavelength of the fiber having a multimode operating wavelength region. A saturated, higher order Bragg grating having first and second order Bragg conditions is fabricated in the optical fiber. The first order of Bragg resonance wavelength of the Bragg grating is within the single mode operating wavelength region of the optical fiber and the second order of Bragg resonance wavelength is below the cutoff wavelength of the fiber within the multimode operating wavelength region. The reflectivities of the saturated Bragg grating at the first and second order Bragg conditions are less than two orders of magnitude of one another. In use, the first and second order Bragg conditions are simultaneously created in the sensor at the respective wavelengths and a signal from the sensor is demodulated with respect to each of the wavelengths corresponding to the first and second order Bragg conditions. Two Bragg conditions have different responsivities to strain and temperature, thus allowing two equations for axial strain and temperature to be found in terms of the measure shifts in the primary and second order Bragg wavelengths. This system of equations can be solved for strain and temperature.

  6. Aero-optical jitter estimation using higher-order wavefronts

    NASA Astrophysics Data System (ADS)

    Whiteley, Matthew R.; Goorskey, David J.; Drye, Richard

    2013-07-01

    Wavefront measurements from wind tunnel or flight testing of an optical system are affected by jitter sources due to the measurement platform, system vibrations, or aero-mechanical buffeting. Depending on the nature of the testing, the wavefront jitter will be a composite of several effects, one of which is the aero-optical jitter; i.e., the wavefront tilt due to random air density fluctuations. To isolate the aero-optical jitter component from recent testing, we have developed an estimation technique that uses only higher-order wavefront measurements to determine the jitter. By analogy with work done previously with free-stream turbulence, we have developed a minimum mean-square error estimator using higher-order wavefront modes to compute the current-frame tilt components through a linear operation. The estimator is determined from computational fluid dynamics evaluation of aero-optical disturbances, but does not depend on the strength of such disturbances. Applying this technique to turret flight test data, we found aero-optical jitter to be 7.7±0.8 μrad and to scale with (ρ/ρSL)M2 (˜1 μrad in the actual test cases examined). The half-power point of the aero-optical jitter variance was found to be ˜2u∞/Dt and to roll off in temporal frequency with a power law between f and f.

  7. Laser-PlasmaWakefield Acceleration with Higher Order Laser Modes

    SciTech Connect

    Geddes, C.G.R.; Cormier-Michel, E.; Esarey, E.; Schroeder, C.B.; Mullowney, P.; Paul, K.; Cary, J.R.; Leemans, W.P.

    2010-06-01

    Laser-plasma collider designs point to staging of multiple accelerator stages at the 10 GeV level, which are to be developed on the upcoming BELLA laser, while Thomson Gamma source designs use GeV stages, both requiring efficiency and low emittance. Design and scaling of stages operating in the quasi-linear regime to address these needs are presented using simulations in the VORPAL framework. In addition to allowing symmetric acceleration of electrons and positrons, which is important for colliders, this regime has the property that the plasma wakefield is proportional to the transverse gradient of the laser intensity profile. We demonstrate use of higher order laser modes to tailor the laser pulse and hence the transverse focusing forces in the plasma. In particular, we show that by using higher order laser modes, we can reduce the focusing fields and hence increase the matched electron beam radius, which is important to increased charge and efficiency, while keeping the low bunch emittance required for applications.

  8. Higher Order Parametric Excitation Modes for Spaceborne Quadrupole Mass Spectrometers

    NASA Technical Reports Server (NTRS)

    Gershman, D. J.; Block, B. P.; Rubin, M.; Benna, M.; Mahaffy, P. R.; Zurbuchen, T. H.

    2011-01-01

    This paper describes a technique to significantly improve upon the mass peak shape and mass resolution of spaceborne quadrupole mass spectrometers (QMSs) through higher order auxiliary excitation of the quadrupole field. Using a novel multiresonant tank circuit, additional frequency components can be used to drive modulating voltages on the quadrupole rods in a practical manner, suitable for both improved commercial applications and spaceflight instruments. Auxiliary excitation at frequencies near twice that of the fundamental quadrupole RF frequency provides the advantages of previously studied parametric excitation techniques, but with the added benefit of increased sensed excitation amplitude dynamic range and the ability to operate voltage scan lines through the center of upper stability islands. Using a field programmable gate array, the amplitudes and frequencies of all QMS signals are digitally generated and managed, providing a robust and stable voltage control system. These techniques are experimentally verified through an interface with a commercial Pfeiffer QMG422 quadrupole rod system.When operating through the center of a stability island formed from higher order auxiliary excitation, approximately 50% and 400% improvements in 1% mass resolution and peak stability were measured, respectively, when compared with traditional QMS operation. Although tested with a circular rod system, the presented techniques have the potential to improve the performance of both circular and hyperbolic rod geometry QMS sensors.

  9. Laser-Plasma Wakefield Acceleration with Higher Order Laser Modes

    SciTech Connect

    Geddes, C. G. R.; Schroeder, C. B.; Cormier-Michel, E.; Mullowney, P.; Paul, K.; Esarey, E.; Cary, J. R.; Leemans, W. P.

    2010-11-04

    Laser-plasma collider designs point to staging of multiple accelerator stages at the 10 GeV level, which are to be developed on the upcoming BELLA laser, while Thomson Gamma source designs use GeV stages, both requiring efficiency and low emittance. Design and scaling of stages operating in the quasi-linear regime to address these needs are presented using simulations in the VORPAL framework. In addition to allowing symmetric acceleration of electrons and positrons, which is important for colliders, this regime has the property that the plasma wakefield is proportional to the transverse gradient of the laser intensity profile. We demonstrate use of higher order laser modes to tailor the laser pulse and hence the transverse focusing forces in the plasma. In particular, we show that by using higher order laser modes, we can reduce the focusing fields and hence increase the matched electron beam radius, which is important to increased charge and efficiency, while keeping the low bunch emittance required for applications.

  10. Inhibitory control gains from higher-order cognitive strategy training.

    PubMed

    Motes, Michael A; Gamino, Jacquelyn F; Chapman, Sandra B; Rao, Neena K; Maguire, Mandy J; Brier, Matthew R; Kraut, Michael A; Hart, John

    2014-02-01

    The present study examined the transfer of higher-order cognitive strategy training to inhibitory control. Middle school students enrolled in a comprehension- and reasoning-focused cognitive strategy training program and passive controls participated. The training program taught students a set of steps for inferring essential gist or themes from materials. Both before and after training or a comparable duration in the case of the passive controls, participants completed a semantically cued Go/No-Go task that was designed to assess the effects of depth of semantic processing on response inhibition and components of event-related potentials (ERP) related to response inhibition. Depth of semantic processing was manipulated by varying the level of semantic categorization required for response selection and inhibition. The SMART-trained group showed inhibitory control gains and changes in fronto-central P3 ERP amplitudes on inhibition trials; whereas, the control group did not. The results provide evidence of the transfer of higher-order cognitive strategy training to inhibitory control and modulation of ERPs associated with semantically cued inhibitory control. The findings are discussed in terms of implications for cognitive strategy training, models of cognitive abilities, and education. PMID:24286804

  11. Higher order parametric excitation modes for spaceborne quadrupole mass spectrometers

    SciTech Connect

    Gershman, D. J.; Block, B. P.; Rubin, M.; Zurbuchen, T. H.; Benna, M.; Mahaffy, P. R.

    2011-12-15

    This paper describes a technique to significantly improve upon the mass peak shape and mass resolution of spaceborne quadrupole mass spectrometers (QMSs) through higher order auxiliary excitation of the quadrupole field. Using a novel multiresonant tank circuit, additional frequency components can be used to drive modulating voltages on the quadrupole rods in a practical manner, suitable for both improved commercial applications and spaceflight instruments. Auxiliary excitation at frequencies near twice that of the fundamental quadrupole RF frequency provides the advantages of previously studied parametric excitation techniques, but with the added benefit of increased sensed excitation amplitude dynamic range and the ability to operate voltage scan lines through the center of upper stability islands. Using a field programmable gate array, the amplitudes and frequencies of all QMS signals are digitally generated and managed, providing a robust and stable voltage control system. These techniques are experimentally verified through an interface with a commercial Pfeiffer QMG422 quadrupole rod system. When operating through the center of a stability island formed from higher order auxiliary excitation, approximately 50% and 400% improvements in 1% mass resolution and peak stability were measured, respectively, when compared with traditional QMS operation. Although tested with a circular rod system, the presented techniques have the potential to improve the performance of both circular and hyperbolic rod geometry QMS sensors.

  12. Visualizing Higher Order Finite Elements: FY05 Yearly Report.

    SciTech Connect

    Thompson, David; Pebay, Philippe Pierre

    2005-11-01

    This report contains an algorithm for decomposing higher-order finite elementsinto regions appropriate for isosurfacing and proves the conditions under which thealgorithm will terminate. Finite elements are used to create piecewise polynomialapproximants to the solution of partial differential equations for which no analyticalsolution exists. These polynomials represent fields such as pressure, stress, and mo-mentim. In the past, these polynomials have been linear in each parametric coordinate.Each polynomial coefficient must be uniquely determined by a simulation, and thesecoefficients are called degrees of freedom. When there are not enough degrees of free-dom, simulations will typically fail to produce a valid approximation to the solution.Recent work has shown that increasing the number of degrees of freedom by increas-ing the order of the polynomial approximation (instead of increasing the number offinite elements, each of which has its own set of coefficients) can allow some typesof simulations to produce a valid approximation with many fewer degrees of freedomthan increasing the number of finite elements alone. However, once the simulation hasdetermined the values of all the coefficients in a higher-order approximant, tools donot exist for visual inspection of the solution.This report focuses on a technique for the visual inspection of higher-order finiteelement simulation results based on decomposing each finite element into simplicialregions where existing visualization algorithms such as isosurfacing will work. Therequirements of the isosurfacing algorithm are enumerated and related to the placeswhere the partial derivatives of the polynomial become zero. The original isosurfacingalgorithm is then applied to each of these regions in turn.3 AcknowledgementThe authors would like to thank David Day and Louis Romero for their insight into poly-nomial system solvers and the LDRD Senior Council for the opportunity to pursue thisresearch. The authors were

  13. Higher Order Mode Heating Analysis for the ILC Superconducting Linacs

    SciTech Connect

    Bane, K.L.F.; Nantista, C.; Adolphsen, C.; /SLAC

    2010-10-27

    The superconducting cavities and interconnects in the 11 km long linacs of the International Linear Collider (ILC) are designed to operate at 2K, where cooling costs are very expensive. It is thus important to minimize cryogenic heat loads. In addition to an unavoidable static load and the dynamic load of the fundamental 1.3 GHz accelerating rf, a further heat source is presented by the higher order mode (HOM) power deposited by the beam. Such modes will be damped by specially designed HOM couplers attached to the cavities (for trapped modes), and by ceramic dampers at 70K that are located between the eight or nine cavity cryomodules (for propagating modes). Brute force calculation of the higher frequency modes excited in a string of cryomodules is limited by computing capacity (see, e.g. [1]). M. Liepe has calculated {approx} 400 longitudinal TM modes in 3 superconducting cavities plus absorbers, up to 8 GHz [2]. Joestingmeier, et al., have used a ray tracing calculation to find the effect at higher frequencies, specifically in the range of tens of GHz and above [3]. In this report we present a scattering matrix approach, which we apply to an rf unit comprising 26 cavities and 3 absorbers. We perform calculations at sample frequencies (up to 20 GHz) to predict the effectiveness of the ceramic dampers in limiting HOM heat deposition at 2K.

  14. "What Do I Do Here?": Higher Order Learning Effects of Enhancing Task Instructions

    ERIC Educational Resources Information Center

    Chamberlain, Susanna; Zuvela, Danni

    2014-01-01

    This paper reports the findings of a one-year research project focused on a series of structured interventions aimed at enhancing task instruction to develop students' understanding of higher assessment practices, and encouraging higher order learning. It describes the nature and iterations of the interventions, made into a large-enrolment online…

  15. Higher-order spectra for identification of nonlinear modal coupling

    NASA Astrophysics Data System (ADS)

    Hickey, Daryl; Worden, Keith; Platten, Michael F.; Wright, Jan R.; Cooper, Jonathan E.

    2009-05-01

    Over the past four decades considerable work has been done in the area of power spectrum estimation. The information contained within the power spectrum relates to a signal's autocorrelation or 'second-order statistics'. The power spectrum provides a complete statistical description of a Gaussian process; however, a problem with this information is that it is phase blind. This problem is addressed if one turns to a system's frequency response function (FRF). The FRF graphs the magnitude and phase of the frequency response of a system; in order to do this it requires information regarding the frequency content of the input and output signals. Situations arise in science and engineering whereby signal analysts are required to look beyond second-order statistics and analyse a signal's higher-order statistics (HOS). HOS or spectra give information on a signal's deviation from Gaussianity and consequently are a good indicator function for the presence of nonlinearity within a system. One of the main problems in nonlinear system identification is that of high modal density. Many modelling schemes involve making some expansion of the nonlinear restoring force in terms of polynomial or other basis terms. If more than one degree-of-freedom is involved this becomes a multivariate problem and the number of candidate terms in the expansion grows explosively with the order of nonlinearity and the number of degrees-of-freedom. This paper attempts to use HOS to detect and qualify nonlinear behaviour for a number of symmetrical and asymmetrical systems over a range of degrees-of-freedom. In doing so the paper also attempts to show that HOS are a more sensitive tool than the FRF in detecting nonlinearity. Furthermore, the object of this paper is to try and identify which modes couple in a nonlinear manner in order to reduce the number of candidate coupling terms, for a model, as much as possible. The bispectrum method has previously been applied to simple low-DOF systems with high

  16. Higher Order Aberration and Astigmatism in Children with Hyperopic Amblyopia

    PubMed Central

    Choi, Seung Kwon

    2016-01-01

    Purpose To investigate the changes in corneal higher-order aberration (HOA) during amblyopia treatment and the correlation between HOA and astigmatism in hyperopic amblyopia children. Methods In this retrospective study, a total of 72 eyes from 72 patients ranging in age from 38 to 161 months were included. Patients were divided into two groups based on the degree of astigmatism. Corneal HOA was measured using a KR-1W aberrometer at the initial visit and at 3-, 6-, and 12-month follow-ups. Correlation analysis was performed to assess the association between HOA and astigmatism. Results A total of 72 patients were enrolled in this study, 37 of which were classified as belonging to the higher astigmatism group, while 35 were assigned to the lower astigmatism group. There was a statistically significant difference in success rate between the higher and lower astigmatism groups. In both groups, all corneal HOAs were significantly reduced during amblyopia treatment. When comparing the two groups, a significant difference in coma HOA at the 12-month follow-up was detected (p = 0.043). In the Pearson correlation test, coma HOA at the 12-month follow-up demonstrated a statistically significant correlation with astigmatism and a stronger correlation with astigmatism in the higher astigmatism group than in the lower astigmatism group (coefficient values, 0.383 and 0.284 as well as p = 0.021 and p = 0.038, respectively). Conclusions HOA, particularly coma HOA, correlated with astigmatism and could exert effects in cases involving hyperopic amblyopia. PMID:26865804

  17. Steganographic system based on higher-order statistics

    NASA Astrophysics Data System (ADS)

    Tzschoppe, Roman; Baeuml, Robert; Huber, Johannes; Kaup, Andre

    2003-06-01

    Universal blind steganalysis attempts to detect steganographic data without knowledge about the applied steganographic system. Farid proposed such a detection algorithm based on higher-order statistics for separating original images from stego images. His method shows an astonishing performance on current steganographic schemes. Starting from the statistical approach in Farid's algorithm, we investigate the well known steganographic tool Jsteg as well as a newer approach proposed by Eggers et al., which relies on histogram-preserving data mapping. Both schemes show weaknesses leading to a certain detectability. Further analysis shows which statistic characteristics make both schemes vulnerable. Based on these results, the histogram preserving approach is enhanced such that it achieves perfect security with respect to Farid's algorithm.

  18. Higher-order resonances in a Stark decelerator

    SciTech Connect

    Meerakker, Sebastiaan Y.T. van de; Bethlem, Hendrick L.; Vanhaecke, Nicolas; Meijer, Gerard

    2005-05-15

    The motion of polar molecules can be controlled by time-varying inhomogeneous electric fields. In a Stark decelerator, this is exploited to select a fraction of a molecular beam that is accelerated, transported, or decelerated. Phase stability ensures that the selected bunch of molecules is kept together throughout the deceleration process. In this paper an extended description of phase stability in a Stark decelerator is given, including higher-order effects. This analysis predicts a wide variety of resonances that originate from the spatial and temporal periodicity of the electric fields. These resonances are experimentally observed using a beam of OH ({sup 2}{pi}{sub 3/2},v=0,J=3/2) radicals passing through a Stark decelerator.

  19. On negative higher-order Kerr effect and filamentation

    NASA Astrophysics Data System (ADS)

    Loriot, V.; Béjot, P.; Ettoumi, W.; Petit, Y.; Kasparian, J.; Henin, S.; Hertz, E.; Lavorel, B.; Faucher, O.; Wolf, J.-P.

    2011-07-01

    As a contribution to the ongoing controversy about the role of higher-order Kerr effect (HOKE) in laser filamentation, we first provide thorough details about the protocol that has been employed to infer the HOKE indices from the experiment. Next, we discuss potential sources of artifact in the experimental measurements of these terms and show that neither the value of the observed birefringence, nor its inversion, nor the intensity at which it is observed, appear to be flawed. Furthermore, we argue that, independently on our values, the principle of including HOKE is straightforward. Due to the different temporal and spectral dynamics, the respective efficiency of defocusing by the plasma and by the HOKE is expected to depend substantially on both incident wavelength and pulse duration. The discussion should therefore focus on defining the conditions where each filamentation regime dominates.

  20. Dependable software through higher-order strategic programming.

    SciTech Connect

    Winter, Victor Lono; Fraij, Fares; Roach, Steve

    2004-03-01

    Program transformation is a restricted form of software construction that can be amenable to formal verification. When successful, the nature of the evidence provided by such a verification is considered strong and can constitute a major component of an argument that a high-consequence or safety-critical system meets its dependability requirements. This article explores the application of novel higher-order strategic programming techniques to the development of a portion of a class loader for a restricted implementation of the Java Virtual Machine (JVM). The implementation is called the SSP and is intended for use in high-consequence safety-critical embedded systems. Verification of the strategic program using ACL2 is also discussed.

  1. Pulse transmission transmitter including a higher order time derivate filter

    DOEpatents

    Dress, Jr., William B.; Smith, Stephen F.

    2003-09-23

    Systems and methods for pulse-transmission low-power communication modes are disclosed. A pulse transmission transmitter includes: a clock; a pseudorandom polynomial generator coupled to the clock, the pseudorandom polynomial generator having a polynomial load input; an exclusive-OR gate coupled to the pseudorandom polynomial generator, the exclusive-OR gate having a serial data input; a programmable delay circuit coupled to both the clock and the exclusive-OR gate; a pulse generator coupled to the programmable delay circuit; and a higher order time derivative filter coupled to the pulse generator. The systems and methods significantly reduce lower-frequency emissions from pulse transmission spread-spectrum communication modes, which reduces potentially harmful interference to existing radio frequency services and users and also simultaneously permit transmission of multiple data bits by utilizing specific pulse shapes.

  2. Evaluative conditioning depends on higher order encoding processes.

    PubMed

    Fiedler, Klaus; Unkelbach, Christian

    2011-06-01

    Evaluative conditioning (EC) is commonly conceived as stimulus-driven associative learning. Here, we show that internally generated encoding activities mediate EC effects: Neutral conditioned stimuli (CS) faces were paired with positive and negative unconditioned stimuli (US) faces. Depending on the encoding task (Is CS a friend vs. enemy of US?), Experiment 1 yielded either normal EC effects (CS adopting US valence) or a reversal. This pattern was conditional on the degree to which encoding judgements affirmed friend or enemy encoding schemes. Experiments 2a and 2b replicated these findings with more clearly valenced US faces and controlling for demand effects. Experiment 3 demonstrated unconditional encoding effects when participants generated friend or enemy relations between CS and US faces. Explicitly stated friend or enemy relations in Experiment 4 left EC effects unaffected. Together, these findings testify to the importance of higher order cognitive processes in conditioning, much in line with recent evidence on the crucial role of conditioning awareness. PMID:21547766

  3. Inflationary scenarios in Starobinsky model with higher order corrections

    SciTech Connect

    Artymowski, Michał; Lalak, Zygmunt; Lewicki, Marek

    2015-06-17

    We consider the Starobinsky inflation with a set of higher order corrections parametrised by two real coefficients λ{sub 1} ,λ{sub 2}. In the Einstein frame we have found a potential with the Starobinsky plateau, steep slope and possibly with an additional minimum, local maximum or a saddle point. We have identified three types of inflationary behaviour that may be generated in this model: i) inflation on the plateau, ii) at the local maximum (topological inflation), iii) at the saddle point. We have found limits on parameters λ{sub i} and initial conditions at the Planck scale which enable successful inflation and disable eternal inflation at the plateau. We have checked that the local minimum away from the GR vacuum is stable and that the field cannot leave it neither via quantum tunnelling nor via thermal corrections.

  4. Detailed Modeling of Higher Order Hierarchical Kepler Star Systems

    NASA Astrophysics Data System (ADS)

    Gore, Joanna; Orosz, Jerome A.

    2016-06-01

    Most stars have stellar companions (i.e. they exist in double, triple, or higher order configurations). Binary star systems are those which contain two stars. These systems are valued scientifically because they allow for the measurement of fundamental stellar properties such as masses and radii. These properties in turn allow for detailed studies of stellar evolution. The Kepler space telescope has discovered roughly 2900 eclipsing binary stars in its field of view. Various studies have shown that roughly 20% of the Kepler eclipsing binaries contain companions are are most likely triple star systems. We present a preliminary survey of the orbital properties of the tertiary bodies in a sample of thirty triple systems. In addition, a small number of the triple systems show eclipse events due to the third star. We present the results of detailed modeling of two of these systems, and discuss how in some cases these triple systems allow for extremely precise measurements of the fundamental stellar parameters.

  5. Predicting perceptual learning from higher-order cortical processing.

    PubMed

    Wang, Fang; Huang, Jing; Lv, Yaping; Ma, Xiaoli; Yang, Bin; Wang, Encong; Du, Boqi; Li, Wu; Song, Yan

    2016-01-01

    Visual perceptual learning has been shown to be highly specific to the retinotopic location and attributes of the trained stimulus. Recent psychophysical studies suggest that these specificities, which have been associated with early retinotopic visual cortex, may in fact not be inherent in perceptual learning and could be related to higher-order brain functions. Here we provide direct electrophysiological evidence in support of this proposition. In a series of event-related potential (ERP) experiments, we recorded high-density electroencephalography (EEG) from human adults over the course of learning in a texture discrimination task (TDT). The results consistently showed that the earliest C1 component (68-84ms), known to reflect V1 activity driven by feedforward inputs, was not modulated by learning regardless of whether the behavioral improvement is location specific or not. In contrast, two later posterior ERP components (posterior P1 and P160-350) over the occipital cortex and one anterior ERP component (anterior P160-350) over the prefrontal cortex were progressively modified day by day. Moreover, the change of the anterior component was closely correlated with improved behavioral performance on a daily basis. Consistent with recent psychophysical and imaging observations, our results indicate that perceptual learning can mainly involve changes in higher-level visual cortex as well as in the neural networks responsible for cognitive functions such as attention and decision making. PMID:26391126

  6. Ordering structured populations in multiplayer cooperation games

    PubMed Central

    Peña, Jorge; Wu, Bin; Traulsen, Arne

    2016-01-01

    Spatial structure greatly affects the evolution of cooperation. While in two-player games the condition for cooperation to evolve depends on a single structure coefficient, in multiplayer games the condition might depend on several structure coefficients, making it difficult to compare different population structures. We propose a solution to this issue by introducing two simple ways of ordering population structures: the containment order and the volume order. If population structure is greater than population structure in the containment or the volume order, then can be considered a stronger promoter of cooperation. We provide conditions for establishing the containment order, give general results on the volume order, and illustrate our theory by comparing different models of spatial games and associated update rules. Our results hold for a large class of population structures and can be easily applied to specific cases once the structure coefficients have been calculated or estimated. PMID:26819335

  7. Phantom Friedmann cosmologies and higher-order characteristics of expansion

    SciTech Connect

    Dabrowski, Mariusz P. . E-mail: mpdabfz@sus.univ.szczecin.pl; Stachowiak, Tomasz . E-mail: toms@oa.uj.edu.pl

    2006-04-15

    We discuss a more general class of phantom (p < -{rho}) cosmologies with various forms of both phantom (w < -1), and standard (w > -1) matter. We show that many types of evolution which include both Big-Bang and Big-Rip singularities are admitted and give explicit examples. Among some interesting models, there exist non-singular oscillating (or 'bounce') cosmologies, which appear due to a competition between positive and negative pressure of variety of matter content. From the point of view of the current observations the most interesting cosmologies are the ones which start with a Big-Bang and terminate at a Big-Rip. A related consequence of having a possibility of two types of singularities is that there exists an unstable static universe approached by the two asymptotic models-one of them reaches Big-Bang, and another reaches Big-Rip. We also give explicit relations between density parameters {omega} and the dynamical characteristics for these generalized phantom models, including higher-order observational characteristics such as jerk and 'kerk.' Finally, we discuss the observational quantities such as luminosity distance, angular diameter, and source counts, both in series expansion and explicitly, for phantom models. Our series expansion formulas for the luminosity distance and the apparent magnitude go as far as to the fourth-order in redshift z term, which includes explicitly not only the jerk, but also the 'kerk' (or 'snap') which may serve as an indicator of the curvature of the universe.

  8. Higher-order spike triggered analysis of neural oscillators.

    PubMed

    Ota, Keisuke; Omori, Toshiaki; Miyakawa, Hiroyoshi; Okada, Masato; Aonishi, Toru

    2012-01-01

    For the purpose of elucidating the neural coding process based on the neural excitability mechanism, researchers have recently investigated the relationship between neural dynamics and the spike triggered stimulus ensemble (STE). Ermentrout et al. analytically derived the relational equation between the phase response curve (PRC) and the spike triggered average (STA). The STA is the first cumulant of the STE. However, in order to understand the neural function as the encoder more explicitly, it is necessary to elucidate the relationship between the PRC and higher-order cumulants of the STE. In this paper, we give a general formulation to relate the PRC and the nth moment of the STE. By using this formulation, we derive a relational equation between the PRC and the spike triggered covariance (STC), which is the covariance of the STE. We show the effectiveness of the relational equation through numerical simulations and use the equation to identify the feature space of the rat hippocampal CA1 pyramidal neurons from their PRCs. Our result suggests that the hippocampal CA1 pyramidal neurons oscillating in the theta frequency range are commonly sensitive to inputs composed of theta and gamma frequency components. PMID:23226249

  9. SPHS: smoothed particle hydrodynamics with a higher order dissipation switch

    NASA Astrophysics Data System (ADS)

    Read, J. I.; Hayfield, T.

    2012-06-01

    We present a novel implementation of smoothed particle hydrodynamics that uses the spatial derivative of the velocity divergence as a higher order dissipation switch. Our switch - which is second order accurate - detects flow convergence before it occurs. If particle trajectories are going to cross, we switch on the usual SPH artificial viscosity, as well as conservative dissipation in all advected fluid quantities (e.g. the entropy). The viscosity and dissipation terms (that are numerical errors) are designed to ensure that all fluid quantities remain single valued as particles approach one another, to respect conservation laws, and to vanish on a given physical scale as the resolution is increased. SPHS alleviates a number of known problems with 'classic' SPH, successfully resolving mixing, and recovering numerical convergence with increasing resolution. An additional key advantage is that - treating the particle mass similarly to the entropy - we are able to use multimass particles, giving significantly improved control over the refinement strategy. We present a wide range of code tests including the Sod shock tube, Sedov-Taylor blast wave, Kelvin-Helmholtz Instability, the 'blob test' and some convergence tests. Our method performs well on all tests, giving good agreement with analytic expectations.

  10. Separating higher-order nonlinearities in transient absorption microscopy

    NASA Astrophysics Data System (ADS)

    Wilson, Jesse W.; Anderson, Miguel; Park, Jong Kang; Fischer, Martin C.; Warren, Warren S.

    2015-08-01

    The transient absorption response of melanin is a promising optically-accessible biomarker for distinguishing malignant melanoma from benign pigmented lesions, as demonstrated by earlier experiments on thin sections from biopsied tissue. The technique has also been demonstrated in vivo, but the higher optical intensity required for detecting these signals from backscattered light introduces higher-order nonlinearities in the transient response of melanin. These components that are higher than linear with respect to the pump or the probe introduce intensity-dependent changes to the overall response that complicate data analysis. However, our data also suggest these nonlinearities might be advantageous to in vivo imaging, in that different types of melanins have different nonlinear responses. Therefore, methods to separate linear from nonlinear components in transient absorption measurements might provide additional information to aid in the diagnosis of melanoma. We will discuss numerical methods for analyzing the various nonlinear contributions to pump-probe signals, with the ultimate objective of real time analysis using digital signal processing techniques. To that end, we have replaced the lock-in amplifier in our pump-probe microscope with a high-speed data acquisition board, and reprogrammed the coprocessor field-programmable gate array (FPGA) to perform lock-in detection. The FPGA lock-in offers better performance than the commercial instrument, in terms of both signal to noise ratio and speed. In addition, the flexibility of the digital signal processing approach enables demodulation of more complicated waveforms, such as spread-spectrum sequences, which has the potential to accelerate microscopy methods that rely on slow relaxation phenomena, such as photo-thermal and phosphorescence lifetime imaging.

  11. Emotion recognition from EEG using higher order crossings.

    PubMed

    Petrantonakis, Panagiotis C; Hadjileontiadis, Leontios J

    2010-03-01

    Electroencephalogram (EEG)-based emotion recognition is a relatively new field in the affective computing area with challenging issues regarding the induction of the emotional states and the extraction of the features in order to achieve optimum classification performance. In this paper, a novel emotion evocation and EEG-based feature extraction technique is presented. In particular, the mirror neuron system concept was adapted to efficiently foster emotion induction by the process of imitation. In addition, higher order crossings (HOC) analysis was employed for the feature extraction scheme and a robust classification method, namely HOC-emotion classifier (HOC-EC), was implemented testing four different classifiers [quadratic discriminant analysis (QDA), k-nearest neighbor, Mahalanobis distance, and support vector machines (SVMs)], in order to accomplish efficient emotion recognition. Through a series of facial expression image projection, EEG data have been collected by 16 healthy subjects using only 3 EEG channels, namely Fp1, Fp2, and a bipolar channel of F3 and F4 positions according to 10-20 system. Two scenarios were examined using EEG data from a single-channel and from combined-channels, respectively. Compared with other feature extraction methods, HOC-EC appears to outperform them, achieving a 62.3% (using QDA) and 83.33% (using SVM) classification accuracy for the single-channel and combined-channel cases, respectively, differentiating among the six basic emotions, i.e., happiness, surprise, anger, fear, disgust, and sadness. As the emotion class-set reduces its dimension, the HOC-EC converges toward maximum classification rate (100% for five or less emotions), justifying the efficiency of the proposed approach. This could facilitate the integration of HOC-EC in human machine interfaces, such as pervasive healthcare systems, enhancing their affective character and providing information about the user's emotional status (e.g., identifying user's emotion

  12. Higher-order gravitational lensing reconstruction using Feynman diagrams

    SciTech Connect

    Jenkins, Elizabeth E.; Manohar, Aneesh V.; Yadav, Amit P.S.; Waalewijn, Wouter J. E-mail: amanohar@ucsd.edu E-mail: ayadav@physics.ucsd.edu

    2014-09-01

    We develop a method for calculating the correlation structure of the Cosmic Microwave Background (CMB) using Feynman diagrams, when the CMB has been modified by gravitational lensing, Faraday rotation, patchy reionization, or other distorting effects. This method is used to calculate the bias of the Hu-Okamoto quadratic estimator in reconstructing the lensing power spectrum up to  O (φ{sup 4}) in the lensing potential φ. We consider both the diagonal noise TT TT, EB EB, etc. and, for the first time, the off-diagonal noise TT TE, TB EB, etc. The previously noted large  O (φ{sup 4}) term in the second order noise is identified to come from a particular class of diagrams. It can be significantly reduced by a reorganization of the φ expansion. These improved estimators have almost no bias for the off-diagonal case involving only one B component of the CMB, such as EE EB.

  13. The effect of higher order harmonics on second order nonlinear phenomena

    NASA Astrophysics Data System (ADS)

    Shahverdi, Amin; Borji, Amir

    2015-05-01

    A new method which is a combination of the harmonic balance and finite difference techniques (HBFD) is proposed for complete time-harmonic solution of the nonlinear wave equation. All interactions between different harmonics up to an arbitrary order can be incorporated. The effect of higher order harmonics on two important nonlinear optical phenomena, namely, the second harmonic generation (SHG) and frequency mixing is investigated by this method and the results are compared with well-known analytical solutions. The method is quite general and can be used to study wave propagation in all nonlinear media.

  14. Student's Perceived Level and Teachers' Teaching Strategies of Higher Order Thinking Skills: A Study on Higher Educational Institutions in Thailand

    ERIC Educational Resources Information Center

    Shukla, Divya; Dungsungnoen, Aj Pattaradanai

    2016-01-01

    Higher order thinking skills (HOTS) has portrayed immense industry demand and the major goal of educational institution in imparting education is to inculcate higher order thinking skills. This compiles and mandate the institutions and instructor to develop the higher order thinking skills among students in order to prepare them for effective…

  15. SVP-like MADS-box protein from Carya cathayensis forms higher-order complexes.

    PubMed

    Wang, Jingjing; Hou, Chuanming; Huang, Jianqin; Wang, Zhengjia; Xu, Yingwu

    2015-03-01

    To properly regulate plant flowering time and construct floral pattern, MADS-domain containing transcription factors must form multimers including homo- and hetero-dimers. They are also active in forming hetero-higher-order complexes with three to five different molecules. However, it is not well known if a MADS-box protein can also form homo-higher-order complex. In this study a biochemical approach is utilized to provide insight into the complex formation for an SVP-like MADS-box protein cloned from hickory. The results indicated that the protein is a heterogeneous higher-order complex with the peak population containing over 20 monomers. Y2H verified the protein to form homo-complex in yeast cells. Western blot of the hickory floral bud sample revealed that the protein exists in higher-order polymers in native. Deletion assays indicated that the flexible C-terminal residues are mainly responsible for the higher-order polymer formation and the heterogeneity. Current results provide direct biochemical evidences for an active MADS-box protein to be a high order complex, much higher than a quartermeric polymer. Analysis suggests that a MADS-box subset may be able to self-assemble into large complexes, and thereby differentiate one subfamily from the other in a higher-order structural manner. Present result is a valuable supplement to the action of mechanism for MADS-box proteins in plant development. PMID:25602439

  16. Higher-Order Finite Elements for Computing Thermal Radiation

    NASA Technical Reports Server (NTRS)

    Gould, Dana C.

    2004-01-01

    Two variants of the finite-element method have been developed for use in computational simulations of radiative transfers of heat among diffuse gray surfaces. Both variants involve the use of higher-order finite elements, across which temperatures and radiative quantities are assumed to vary according to certain approximations. In this and other applications, higher-order finite elements are used to increase (relative to classical finite elements, which are assumed to be isothermal) the accuracies of final numerical results without having to refine computational meshes excessively and thereby incur excessive computation times. One of the variants is termed the radiation sub-element (RSE) method, which, itself, is subject to a number of variations. This is the simplest and most straightforward approach to representation of spatially variable surface radiation. Any computer code that, heretofore, could model surface-to-surface radiation can incorporate the RSE method without major modifications. In the basic form of the RSE method, each finite element selected for use in computing radiative heat transfer is considered to be a parent element and is divided into sub-elements for the purpose of solving the surface-to-surface radiation-exchange problem. The sub-elements are then treated as classical finite elements; that is, they are assumed to be isothermal, and their view factors and absorbed heat fluxes are calculated accordingly. The heat fluxes absorbed by the sub-elements are then transferred back to the parent element to obtain a radiative heat flux that varies spatially across the parent element. Variants of the RSE method involve the use of polynomials to interpolate and/or extrapolate to approximate spatial variations of physical quantities. The other variant of the finite-element method is termed the integration method (IM). Unlike in the RSE methods, the parent finite elements are not subdivided into smaller elements, and neither isothermality nor other

  17. A viscoelastic higher-order beam finite element

    NASA Technical Reports Server (NTRS)

    Johnson, Arthur R.; Tressler, Alexander

    1996-01-01

    A viscoelastic internal variable constitutive theory is applied to a higher-order elastic beam theory and finite element formulation. The behavior of the viscous material in the beam is approximately modeled as a Maxwell solid. The finite element formulation requires additional sets of nodal variables for each relaxation time constant needed by the Maxwell solid. Recent developments in modeling viscoelastic material behavior with strain variables that are conjugate to the elastic strain measures are combined with advances in modeling through-the-thickness stresses and strains in thick beams. The result is a viscous thick-beam finite element that possesses superior characteristics for transient analysis since its nodal viscous forces are not linearly dependent an the nodal velocities, which is the case when damping matrices are used. Instead, the nodal viscous forces are directly dependent on the material's relaxation spectrum and the history of the nodal variables through a differential form of the constitutive law for a Maxwell solid. The thick beam quasistatic analysis is explored herein as a first step towards developing more complex viscoelastic models for thick plates and shells, and for dynamic analyses. The internal variable constitutive theory is derived directly from the Boltzmann superposition theorem. The mechanical strains and the conjugate internal strains are shown to be related through a system of first-order, ordinary differential equations. The total time-dependent stress is the superposition of its elastic and viscous components. Equations of motion for the solid are derived from the virtual work principle using the total time-dependent stress. Numerical examples for the problems of relaxation, creep, and cyclic creep are carried out for a beam made from an orthotropic Maxwell solid.

  18. Pressure and higher-order spectra for homogeneous isotropic turbulence

    NASA Technical Reports Server (NTRS)

    Pullin, D. I.; Rogallo, R. S.

    1994-01-01

    The spectra of the pressure, and other higher-order quantities including the dissipation, the enstrophy, and the square of the longitudinal velocity derivative are computed using data obtained from direct numerical simulation of homogeneous isotropic turbulence at Taylor-Reynolds numbers R(sub lambda) in the range 38 - 170. For the pressure spectra we find reasonable collapse in the dissipation range (of the velocity spectrum) when scaled in Kolmogorov variables and some evidence, which is not conclusive, for the existence of a k(exp -7/3) inertial range where k = absolute value of K, is the modulus of the wavenumber. The power spectra of the dissipation, the enstrophy, and the square of the longitudinal velocity derivative separate in the dissipation range, but appear to converge together in the short inertial range of the simulations. A least-squares curve-fit in the dissipation range for one value of R(sub lambda) = 96 gives a form for the spectrum of the dissipation as k(exp 0)exp(-Ck eta), for k(eta) greater than 0.2, where eta is the Kolmogorov length and C is approximately equal to 2.5.

  19. Invariants of velocities and higher-order Grassmann bundles

    NASA Astrophysics Data System (ADS)

    Grigore, Dan Radu; Krupka, Demeter

    1998-02-01

    An ( r, n)-velocity is an r-jet with source at 0 ɛ Rn, and target in a manifold Y. An ( r, n)-velocity is said to be regular if it has a representative which is an immersion at 0 ɛ Rn. The manifold TnrY of ( r, n)-velocities as well as its open, Lnr-invariant, dense submanifold Imm TnrY of regular ( r, n)-velocities, are endowed with a natural action of the differential group Lnr of invertible r-jets with source and target 0 ɛ Rn. In this paper, we describe all continuous, Lnr-invariant, real-valued functions on TnrY and Imm TnrY. We find local bases of Lnr-invariants Imm TnrY in an explicit, recurrent form. To this purpose, higher-order Grassmann bundles are considered as the corresponding quotients P nrY = Imm{T nrY }/{L nr}, and their basic properties are studied. We show that nontrivial Lnr-invariants on Imm TnrY cannot be continuously extended onto TnrY.

  20. Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions

    PubMed Central

    Taylor, Matthew B.; Ehrenreich, Ian M.

    2015-01-01

    Disruption of certain genes can reveal cryptic genetic variants that do not typically show phenotypic effects. Because this phenomenon, which is referred to as ‘phenotypic capacitance’, is a potential source of trait variation and disease risk, it is important to understand how it arises at the genetic and molecular levels. Here, we use a cryptic colony morphology trait that segregates in a yeast cross to explore the mechanisms underlying phenotypic capacitance. We find that the colony trait is expressed when a mutation in IRA2, a negative regulator of the Ras pathway, co-occurs with specific combinations of cryptic variants in six genes. Four of these genes encode transcription factors that act downstream of the Ras pathway, indicating that the phenotype involves genetically complex changes in the transcriptional regulation of Ras targets. We provide evidence that the IRA2 mutation reveals the phenotypic effects of the cryptic variants by disrupting the transcriptional silencing of one or more genes that contribute to the trait. Supporting this role for the IRA2 mutation, deletion of SFL1, a repressor that acts downstream of the Ras pathway, also reveals the phenotype, largely due to the same cryptic variants that were detected in the IRA2 mutant cross. Our results illustrate how higher-order genetic interactions among mutations and cryptic variants can result in phenotypic capacitance in specific genetic backgrounds, and suggests these interactions might reflect genetically complex changes in gene expression that are usually suppressed by negative regulation. PMID:26484664

  1. Higher order finite element analysis of thick composite laminates

    NASA Technical Reports Server (NTRS)

    Goering, J.; Kim, H. J.

    1992-01-01

    A higher order, sub-parametric, laminated, 3D solid finite element was used for the analysis of very thick laminated composite plates. The geometry of this element is defined by four nodes in the X-Y plane which define a prism of material through the thickness of the laminate. There are twenty-four degrees of freedom at each node; translations at the upper and lower surfaces of the laminate in each of the three coordinate directions, and the derivatives of these translations with respect to each coordinate. This choice of degrees of freedom leads to displacement and strain compatibility at the corners. Stacking sequence effects are accounted for by explicitly integrating the strain energy density through the thickness of the element. The laminated solid element was combined with a gap-contact element to analyze thick laminated composite lugs loaded through flexible pins. The resulting model accounts for pin bending effects that produce non-uniform bearing stresses through the thickness of the lug. A thick composite lug experimental test program was performed, and provided data that was used to validate the analytical model. Two lug geometries and three stacking sequences were tested.

  2. Higher order solutions to ion-acoustic solitons in a weakly relativistic two-fluid plasma

    SciTech Connect

    Gill, Tarsem Singh; Bala, Parveen; Kaur, Harvinder

    2008-12-15

    The nonlinear wave structure of small amplitude ion-acoustic solitary waves (IASs) is investigated in a two-fluid plasma consisting of weakly relativistic streaming ions and electrons. Using the reductive perturbation theory, the basic set of governing equations is reduced to the Korteweg-de Vries (KdV) equation for the lowest order perturbation. This analysis is further extended using the renormalization technique for the inclusion of higher order nonlinear and dispersive effects for better accuracy. The effect of higher order correction and various parameters on the soliton characteristics is investigated and also discussed.

  3. Higher-order renormalization of graphene many-body theory

    NASA Astrophysics Data System (ADS)

    González, J.

    2012-08-01

    We study the many-body theory of graphene Dirac quasiparticles interacting via the long-range Coulomb potential, taking as a starting point the ladder approximation to different vertex functions. We test in this way the low-energy behavior of the electron system beyond the simple logarithmic dependence of electronic correlators on the high-energy cutoff, which is characteristic of the large- N approximation. We show that the graphene many-body theory is perfectly renormalizable in the ladder approximation, as all higher powers in the cutoff dependence can be absorbed into the redefinition of a finite number of parameters (namely, the Fermi velocity and the weight of the fields) that remain free of infrared divergences even at the charge neutrality point. We illustrate this fact in the case of the vertex for the current density, where a complete cancellation between the cutoff dependences of vertex and electron self-energy corrections becomes crucial for the preservation of the gauge invariance of the theory. The other potentially divergent vertex corresponds to the staggered (sublattice odd) charge density, which is made cutoff independent by a redefinition in the scale of the density operator. This allows to compute a well-defined, scale invariant anomalous dimension to all orders in the ladder series, which becomes singular at a value of the interaction strength marking the onset of chiral symmetry breaking (and gap opening) in the Dirac field theory. The critical coupling we obtain in this way matches with great accuracy the value found with a quite different method, based on the resolution of the gap equation, thus reassuring the predictability of our renormalization approach.

  4. Dynamics and phenomenology of higher order gravity cosmological models

    NASA Astrophysics Data System (ADS)

    Moldenhauer, Jacob Andrew

    2010-10-01

    I present here some new results about a systematic approach to higher-order gravity (HOG) cosmological models. The HOG models are derived from curvature invariants that are more general than the Einstein-Hilbert action. Some of the models exhibit late-time cosmic acceleration without the need for dark energy and fit some current observations. The open question is that there are an infinite number of invariants that one could select, and many of the published papers have stressed the need to find a systematic approach that will allow one to study methodically the various possibilities. We explore a new connection that we made between theorems from the theory of invariants in general relativity and these cosmological models. In summary, the theorems demonstrate that curvature invariants are not all independent from each other and that for a given Ricci Segre type and Petrov type (symmetry classification) of the space-time, there exists a complete minimal set of independent invariants (a basis) in terms of which all the other invariants can be expressed. As an immediate consequence of the proposed approach, the number of invariants to consider is dramatically reduced from infinity to four invariants in the worst case and to only two invariants in the cases of interest, including all Friedmann-Lemaitre-Robertson-Walker metrics. We derive models that pass stability and physical acceptability conditions. We derive dynamical equations and phase portrait analyses that show the promise of the systematic approach. We consider observational constraints from magnitude-redshift Supernovae Type Ia data, distance to the last scattering surface of the Cosmic Microwave Background radiation, and Baryon Acoustic Oscillations. We put observational constraints on general HOG models. We constrain different forms of the Gauss-Bonnet, f(G), modified gravity models with these observations. We show some of these models pass solar system tests. We seek to find models that pass physical and

  5. Construction of higher order accurate vortex and particle methods

    NASA Technical Reports Server (NTRS)

    Nicolaides, R. A.

    1986-01-01

    The standard point vortex method has recently been shown to be of high order of accuracy for problems on the whole plane, when using a uniform initial subdivision for assigning the vorticity to the points. If obstacles are present in the flow, this high order deteriorates to first or second order. New vortex methods are introduced which are of arbitrary accuracy (under regularity assumptions) regardless of the presence of bodies and the uniformity of the initial subdivision.

  6. Addition of higher order plate and shell elements into NASTRAN computer program

    NASA Technical Reports Server (NTRS)

    Narayanaswami, R.; Goglia, G. L.

    1976-01-01

    Two higher order plate elements, the linear strain triangular membrane element and the quintic bending element, along with a shallow shell element, suitable for inclusion into the NASTRAN (NASA Structural Analysis) program are described. Additions to the NASTRAN Theoretical Manual, Users' Manual, Programmers' Manual and the NASTRAN Demonstration Problem Manual, for inclusion of these elements into the NASTRAN program are also presented.

  7. Assessing Competitive Structures in Higher Education.

    ERIC Educational Resources Information Center

    Rowse, Glenwood, L.; Wing, Paul

    1982-01-01

    Recent enrollment shifts and current knowledge of the dynamics of competition in higher education are examined. Results of a study identifying several structural characteristics of competing college groups in New York State are reported and implications for future enrollment patterns there and elsewhere are discussed. (Author/MSE)

  8. Correcting vortex splitting in higher order vortex beams.

    PubMed

    Neo, Richard; Tan, Shiaw Juen; Zambrana-Puyalto, Xavier; Leon-Saval, Sergio; Bland-Hawthorn, Joss; Molina-Terriza, Gabriel

    2014-04-21

    We demonstrate a general method for the first order compensation of singularity splitting in a vortex beam at a single plane. By superimposing multiple forked holograms on the SLM used to generate the vortex beam, we are able to compensate vortex splitting and generate beams with desired phase singularities of order ℓ = 0, 1, 2, and 3 in one plane. We then extend this method by application of a radial phase, in order to simultaneously compensate the observed vortex splitting at two planes (near and far field) for an ℓ = 2 beam. PMID:24787874

  9. Proper orthogonal decomposition-based spectral higher-order stochastic estimation

    NASA Astrophysics Data System (ADS)

    Baars, Woutijn J.; Tinney, Charles E.

    2014-05-01

    A unique routine, capable of identifying both linear and higher-order coherence in multiple-input/output systems, is presented. The technique combines two well-established methods: Proper Orthogonal Decomposition (POD) and Higher-Order Spectra Analysis. The latter of these is based on known methods for characterizing nonlinear systems by way of Volterra series. In that, both linear and higher-order kernels are formed to quantify the spectral (nonlinear) transfer of energy between the system's input and output. This reduces essentially to spectral Linear Stochastic Estimation when only first-order terms are considered, and is therefore presented in the context of stochastic estimation as spectral Higher-Order Stochastic Estimation (HOSE). The trade-off to seeking higher-order transfer kernels is that the increased complexity restricts the analysis to single-input/output systems. Low-dimensional (POD-based) analysis techniques are inserted to alleviate this void as POD coefficients represent the dynamics of the spatial structures (modes) of a multi-degree-of-freedom system. The mathematical framework behind this POD-based HOSE method is first described. The method is then tested in the context of jet aeroacoustics by modeling acoustically efficient large-scale instabilities as combinations of wave packets. The growth, saturation, and decay of these spatially convecting wave packets are shown to couple both linearly and nonlinearly in the near-field to produce waveforms that propagate acoustically to the far-field for different frequency combinations.

  10. Proper orthogonal decomposition-based spectral higher-order stochastic estimation

    SciTech Connect

    Baars, Woutijn J.; Tinney, Charles E.

    2014-05-15

    A unique routine, capable of identifying both linear and higher-order coherence in multiple-input/output systems, is presented. The technique combines two well-established methods: Proper Orthogonal Decomposition (POD) and Higher-Order Spectra Analysis. The latter of these is based on known methods for characterizing nonlinear systems by way of Volterra series. In that, both linear and higher-order kernels are formed to quantify the spectral (nonlinear) transfer of energy between the system's input and output. This reduces essentially to spectral Linear Stochastic Estimation when only first-order terms are considered, and is therefore presented in the context of stochastic estimation as spectral Higher-Order Stochastic Estimation (HOSE). The trade-off to seeking higher-order transfer kernels is that the increased complexity restricts the analysis to single-input/output systems. Low-dimensional (POD-based) analysis techniques are inserted to alleviate this void as POD coefficients represent the dynamics of the spatial structures (modes) of a multi-degree-of-freedom system. The mathematical framework behind this POD-based HOSE method is first described. The method is then tested in the context of jet aeroacoustics by modeling acoustically efficient large-scale instabilities as combinations of wave packets. The growth, saturation, and decay of these spatially convecting wave packets are shown to couple both linearly and nonlinearly in the near-field to produce waveforms that propagate acoustically to the far-field for different frequency combinations.

  11. A probabilistic model of visual working memory: Incorporating higher order regularities into working memory capacity estimates.

    PubMed

    Brady, Timothy F; Tenenbaum, Joshua B

    2013-01-01

    When remembering a real-world scene, people encode both detailed information about specific objects and higher order information like the overall gist of the scene. However, formal models of change detection, like those used to estimate visual working memory capacity, assume observers encode only a simple memory representation that includes no higher order structure and treats items independently from one another. We present a probabilistic model of change detection that attempts to bridge this gap by formalizing the role of perceptual organization and allowing for richer, more structured memory representations. Using either standard visual working memory displays or displays in which the items are purposefully arranged in patterns, we find that models that take into account perceptual grouping between items and the encoding of higher order summary information are necessary to account for human change detection performance. Considering the higher order structure of items in visual working memory will be critical for models to make useful predictions about observers' memory capacity and change detection abilities in simple displays as well as in more natural scenes. PMID:23230888

  12. Higher-order diagrammatic vibrational coupled-cluster theory

    NASA Astrophysics Data System (ADS)

    Faucheaux, Jacob A.; Hirata, So

    2015-10-01

    Diagrammatically size-consistent and basis-set-free vibrational coupled-cluster (XVCC) theory for both zero-point energies and transition frequencies of a molecule, the latter through the equation-of-motion (EOM) formalism, is defined for an nth-order Taylor-series potential energy surface (PES). Quantum-field-theoretical tools (the rules of normal-ordered second quantization and Feynman-Goldstone diagrams) for deriving their working equations are established. The equations of XVCC and EOM-XVCC including up to the mth-order excitation operators are derived and implemented with the aid of computer algebra in the range of 1 ≤ m ≤ 8. Algorithm optimizations known as strength reduction, intermediate reuse, and factorization are carried out before code generation, reducing the cost scaling of the mth-order XVCC and EOM-XVCC in an nth-order Taylor-series PES (m ≥ n) to the optimal value of O(Nm+⌊n/2⌋), where N is the number of modes. The calculated zero-point energies and frequencies of fundamentals, overtones, and combinations as well as Fermi-resonant modes display rapid and nearly monotonic convergence with m towards the exact values for the PES. The theory with the same excitation rank as the truncation order of the Taylor-series PES (m = n) seems to strike the best cost-accuracy balance, achieving the accuracy of a few tenths of cm-1 for transitions involving (m - 3) modes and of a few cm-1 for those involving (m - 2) modes. The relationships between XVCC and the vibrational coupled-cluster theories of Prasad and coworkers and of Christiansen and coworkers as well as the size-extensive vibrational self-consistent-field and many-body perturbation theories are also elucidated.

  13. Higher-order diagrammatic vibrational coupled-cluster theory.

    PubMed

    Faucheaux, Jacob A; Hirata, So

    2015-10-01

    Diagrammatically size-consistent and basis-set-free vibrational coupled-cluster (XVCC) theory for both zero-point energies and transition frequencies of a molecule, the latter through the equation-of-motion (EOM) formalism, is defined for an nth-order Taylor-series potential energy surface (PES). Quantum-field-theoretical tools (the rules of normal-ordered second quantization and Feynman-Goldstone diagrams) for deriving their working equations are established. The equations of XVCC and EOM-XVCC including up to the mth-order excitation operators are derived and implemented with the aid of computer algebra in the range of 1 ≤ m ≤ 8. Algorithm optimizations known as strength reduction, intermediate reuse, and factorization are carried out before code generation, reducing the cost scaling of the mth-order XVCC and EOM-XVCC in an nth-order Taylor-series PES (m ≥ n) to the optimal value of O(N(m+⌊n/2⌋)), where N is the number of modes. The calculated zero-point energies and frequencies of fundamentals, overtones, and combinations as well as Fermi-resonant modes display rapid and nearly monotonic convergence with m towards the exact values for the PES. The theory with the same excitation rank as the truncation order of the Taylor-series PES (m = n) seems to strike the best cost-accuracy balance, achieving the accuracy of a few tenths of cm(-1) for transitions involving (m - 3) modes and of a few cm(-1) for those involving (m - 2) modes. The relationships between XVCC and the vibrational coupled-cluster theories of Prasad and coworkers and of Christiansen and coworkers as well as the size-extensive vibrational self-consistent-field and many-body perturbation theories are also elucidated. PMID:26450290

  14. Rapidity window dependences of higher order cumulants and diffusion master equation

    NASA Astrophysics Data System (ADS)

    Kitazawa, Masakiyo

    2015-10-01

    We study the rapidity window dependences of higher order cumulants of conserved charges observed in relativistic heavy ion collisions. The time evolution and the rapidity window dependence of the non-Gaussian fluctuations are described by the diffusion master equation. Analytic formulas for the time evolution of cumulants in a rapidity window are obtained for arbitrary initial conditions. We discuss that the rapidity window dependences of the non-Gaussian cumulants have characteristic structures reflecting the non-equilibrium property of fluctuations, which can be observed in relativistic heavy ion collisions with the present detectors. It is argued that various information on the thermal and transport properties of the hot medium can be revealed experimentally by the study of the rapidity window dependences, especially by the combined use, of the higher order cumulants. Formulas of higher order cumulants for a probability distribution composed of sub-probabilities, which are useful for various studies of non-Gaussian cumulants, are also presented.

  15. A Hypergraph-Based Reduction for Higher-Order Binary Markov Random Fields.

    PubMed

    Fix, Alexander; Gruber, Aritanan; Boros, Endre; Zabih, Ramin

    2015-07-01

    Higher-order Markov Random Fields, which can capture important properties of natural images, have become increasingly important in computer vision. While graph cuts work well for first-order MRF's, until recently they have rarely been effective for higher-order MRF's. Ishikawa's graph cut technique [1], [2] shows great promise for many higher-order MRF's. His method transforms an arbitrary higher-order MRF with binary labels into a first-order one with the same minima. If all the terms are submodular the exact solution can be easily found; otherwise, pseudoboolean optimization techniques can produce an optimal labeling for a subset of the variables. We present a new transformation with better performance than [1], [2], both theoretically and experimentally. While [1], [2] transforms each higher-order term independently, we use the underlying hypergraph structure of the MRF to transform a group of terms at once. For n binary variables, each of which appears in terms with k other variables, at worst we produce n non-submodular terms, while [1], [2] produces O(nk). We identify a local completeness property under which our method perform even better, and show that under certain assumptions several important vision problems (including common variants of fusion moves) have this property. We show experimentally that our method produces smaller weight of non-submodular edges, and that this metric is directly related to the effectiveness of QPBO [3]. Running on the same field of experts dataset used in [1], [2] we optimally label significantly more variables (96 versus 80 percent) and converge more rapidly to a lower energy. Preliminary experiments suggest that some other higher-order MRF's used in stereo [4] and segmentation [5] are also locally complete and would thus benefit from our work. PMID:26352447

  16. The dynamin middle domain is critical for tetramerization and higher-order self-assembly

    PubMed Central

    Ramachandran, Rajesh; Surka, Mark; Chappie, Joshua S; Fowler, Douglas M; Foss, Ted R; Song, Byeong Doo; Schmid, Sandra L

    2007-01-01

    The large multidomain GTPase dynamin self-assembles around the necks of deeply invaginated coated pits at the plasma membrane and catalyzes vesicle scission by mechanisms that are not yet completely understood. Although a structural role for the ‘middle' domain in dynamin function has been suggested, it has not been experimentally established. Furthermore, it is not clear whether this putative function pertains to dynamin structure in the unassembled state or to its higher-order self-assembly or both. Here, we demonstrate that two mutations in this domain, R361S and R399A, disrupt the tetrameric structure of dynamin in the unassembled state and impair its ability to stably bind to and nucleate higher-order self-assembly on membranes. Consequently, these mutations also impair dynamin's assembly-dependent stimulated GTPase activity. PMID:17170701

  17. The dynamin middle domain is critical for tetramerization and higher-order self-assembly.

    PubMed

    Ramachandran, Rajesh; Surka, Mark; Chappie, Joshua S; Fowler, Douglas M; Foss, Ted R; Song, Byeong Doo; Schmid, Sandra L

    2007-01-24

    The large multidomain GTPase dynamin self-assembles around the necks of deeply invaginated coated pits at the plasma membrane and catalyzes vesicle scission by mechanisms that are not yet completely understood. Although a structural role for the 'middle' domain in dynamin function has been suggested, it has not been experimentally established. Furthermore, it is not clear whether this putative function pertains to dynamin structure in the unassembled state or to its higher-order self-assembly or both. Here, we demonstrate that two mutations in this domain, R361S and R399A, disrupt the tetrameric structure of dynamin in the unassembled state and impair its ability to stably bind to and nucleate higher-order self-assembly on membranes. Consequently, these mutations also impair dynamin's assembly-dependent stimulated GTPase activity. PMID:17170701

  18. Controlled excitation of higher radial order whispering gallery modes with metallic diffraction grating.

    PubMed

    Zhou, Yanyan; Luan, Feng; Gu, Bobo; Yu, Xia

    2015-02-23

    Metallic diffraction grating coupler is investigated for controlled excitation of whispering gallery modes (WGMs) of different radial orders. Based on effective mode index calculations and finite difference time domain method, it is found that higher radial order WGMs can be separated from the fundamental modes by sending them into the opposite propagation direction. By phase-matching designs, the metallic diffraction grating provides extra freedom to switch propagation directions, and is able to selectively enhance or suppress different radial-order WGMs. Such structure offers a simple and practical configuration for various WGM applications including liquid sensing, band pass filtering and fiber lasers. PMID:25836534

  19. Higher-Order Correlations in Non-Stationary Parallel Spike Trains: Statistical Modeling and Inference

    PubMed Central

    Staude, Benjamin; Grün, Sonja; Rotter, Stefan

    2009-01-01

    The extent to which groups of neurons exhibit higher-order correlations in their spiking activity is a controversial issue in current brain research. A major difficulty is that currently available tools for the analysis of massively parallel spike trains (N >10) for higher-order correlations typically require vast sample sizes. While multiple single-cell recordings become increasingly available, experimental approaches to investigate the role of higher-order correlations suffer from the limitations of available analysis techniques. We have recently presented a novel method for cumulant-based inference of higher-order correlations (CuBIC) that detects correlations of higher order even from relatively short data stretches of length T = 10–100 s. CuBIC employs the compound Poisson process (CPP) as a statistical model for the population spike counts, and assumes spike trains to be stationary in the analyzed data stretch. In the present study, we describe a non-stationary version of the CPP by decoupling the correlation structure from the spiking intensity of the population. This allows us to adapt CuBIC to time-varying firing rates. Numerical simulations reveal that the adaptation corrects for false positive inference of correlations in data with pure rate co-variation, while allowing for temporal variations of the firing rates has a surprisingly small effect on CuBICs sensitivity for correlations. PMID:20725510

  20. Higher-Order Semi-Implicit Projection Methods

    SciTech Connect

    Minion, M L

    2001-09-06

    A semi-implicit form of the method of spectral deferred corrections is applied to the solution of the incompressible Navier-Stokes equations. A methodology for constructing semi-implicit projection methods with arbitrarily high order of temporal accuracy in both the velocity and pressure is presented. Three variations of projection methods are discussed which differ in the manner in which the auxiliary velocity and the pressure are calculated. The presentation will make clear that project methods in general need not be viewed as fractional step methods as is often the practice. Two simple numerical examples re used to demonstrate fourth-order accuracy in time for an implementation of each variation of projection method.

  1. Machine learning using a higher order correlation network

    SciTech Connect

    Lee, Y.C.; Doolen, G.; Chen, H.H.; Sun, G.Z.; Maxwell, T.; Lee, H.Y.

    1986-01-01

    A high-order correlation tensor formalism for neural networks is described. The model can simulate auto associative, heteroassociative, as well as multiassociative memory. For the autoassociative model, simulation results show a drastic increase in the memory capacity and speed over that of the standard Hopfield-like correlation matrix methods. The possibility of using multiassociative memory for a learning universal inference network is also discussed. 9 refs., 5 figs.

  2. Higher-order numerical solutions using cubic splines

    NASA Technical Reports Server (NTRS)

    Rubin, S. G.; Khosla, P. K.

    1976-01-01

    A cubic spline collocation procedure was developed for the numerical solution of partial differential equations. This spline procedure is reformulated so that the accuracy of the second-derivative approximation is improved and parallels that previously obtained for lower derivative terms. The final result is a numerical procedure having overall third-order accuracy of a nonuniform mesh. Solutions using both spline procedures, as well as three-point finite difference methods, are presented for several model problems.

  3. Wavelet steerability and the higher-order Riesz transform.

    PubMed

    Unser, Michael; Van De Ville, Dimitri

    2010-03-01

    Our main goal in this paper is to set the foundations of a general continuous-domain framework for designing steerable, reversible signal transformations (a.k.a. frames) in multiple dimensions ( d >or= 2). To that end, we introduce a self-reversible, Nth-order extension of the Riesz transform. We prove that this generalized transform has the following remarkable properties: shift-invariance, scale-invariance, inner-product preservation, and steerability. The pleasing consequence is that the transform maps any primary wavelet frame (or basis) of [Formula: see text] into another "steerable" wavelet frame, while preserving the frame bounds. The concept provides a functional counterpart to Simoncelli's steerable pyramid whose construction was primarily based on filterbank design. The proposed mechanism allows for the specification of wavelets with any order of steerability in any number of dimensions; it also yields a perfect reconstruction filterbank algorithm. We illustrate the method with the design of a novel family of multidimensional Riesz-Laplace wavelets that essentially behave like the N th-order partial derivatives of an isotropic Gaussian kernel. PMID:20031498

  4. Higher-order Hamiltonian fluid reduction of Vlasov equation

    SciTech Connect

    Perin, M.; Chandre, C.; Morrison, P.J.; Tassi, E.

    2014-09-15

    From the Hamiltonian structure of the Vlasov equation, we build a Hamiltonian model for the first three moments of the Vlasov distribution function, namely, the density, the momentum density and the specific internal energy. We derive the Poisson bracket of this model from the Poisson bracket of the Vlasov equation, and we discuss the associated Casimir invariants.

  5. Higher-Order Theory for Functionally Graded Materials

    NASA Technical Reports Server (NTRS)

    Aboudi, J.; Pindera, M. J.; Arnold, Steven M.

    2001-01-01

    Functionally graded materials (FGM's) are a new generation of engineered materials wherein the microstructural details are spatially varied through nonuniform distribution of the reinforcement phase(s). Engineers accomplish this by using reinforcements with different properties, sizes, and shapes, as well as by interchanging the roles of the reinforcement and matrix phases in a continuous manner (ref. 1). The result is a microstructure that produces continuously or discretely changing thermal and mechanical properties at the macroscopic or continuum scale. This new concept of engineering the material's microstructure marks the beginning of a revolution both in the materials science and mechanics of materials areas since it allows one, for the first time, to fully integrate the material and structural considerations into the final design of structural components. Functionally graded materials are ideal candidates for applications involving severe thermal gradients, ranging from thermal structures in advanced aircraft and aerospace engines to computer circuit boards. Owing to the many variables that control the design of functionally graded microstructures, full exploitation of the FGM's potential requires the development of appropriate modeling strategies for their response to combined thermomechanical loads. Previously, most computational strategies for the response of FGM's did not explicitly couple the material's heterogeneous microstructure with the structural global analysis. Rather, local effective or macroscopic properties at a given point within the FGM were first obtained through homogenization based on a chosen micromechanics scheme and then subsequently used in a global thermomechanical analysis.

  6. Multilevel Higher-Order Item Response Theory Models

    ERIC Educational Resources Information Center

    Huang, Hung-Yu; Wang, Wen-Chung

    2014-01-01

    In the social sciences, latent traits often have a hierarchical structure, and data can be sampled from multiple levels. Both hierarchical latent traits and multilevel data can occur simultaneously. In this study, we developed a general class of item response theory models to accommodate both hierarchical latent traits and multilevel data. The…

  7. Ordered macromolecular structures in ferrofluid mixtures

    SciTech Connect

    Hayter, J.B.; Pynn, R.; Charles, S.; Skjeltorp, A.T.; Trewhella, J.; Stubbs, G.; Timmins, P.

    1989-04-03

    We have observed ordering of dilute dispersions of spherical and cylindrical macromolecules in magnetized ferrofluids. The order results from structural correlations between macromolecular and ferrofluid particles rather than from macroscopic magnetostatic effects. We have aligned elongated macromolecules by this technique and have obtained anisotropic neutron-diffraction patterns, which reflect the internal structure of the macromolecules. The method provides a tool for orienting suspended macromolecular assemblies which are not amenable to conventional alignment techniques.

  8. Higher-order symplectic Born-Oppenheimer molecular dynamics

    SciTech Connect

    Niklasson, Anders; Bock, Nicolas; Challacombe, Matt; Odell, Anders; Delin, Anna; Johansson, Borje

    2009-01-01

    The extended Lagrangian formulation of time-reversible Born-Oppenheimer molecular dynamics (TR-BOMD) enables the use of geometric integrators in the propagation of both the nuclear and the electronic degrees of freedom on the Born-Oppenheimer potential energy surface. Different symplectic integrators up to the 6th order have been adapted and optimized to TR-BOMD in the framework of ab initio self-consistent-field theory. It is shown how the accuracy can be significantly improved compared to a conventional Verlet integration at the same level of computational cost, in particular for the case of very high accuracy requirements.

  9. The role of alphoid higher order repeats (HORs) in the centromere folding.

    PubMed

    Rosandić, Marija; Gluncić, Matko; Paar, Vladimir; Basar, Ivan

    2008-10-01

    Understanding the folding of centromere DNA in the maximally condensed methaphase chromosome remains a basic challenge in cell biology. We propose here a set of structural models with a graphical presentation of alphoid higher order repeat (HOR) distribution in the centromere folding, based on the assumption of encryption key for microtubule-centromere interaction which arises from chromosome-specific crystal-like structure of HORs. Specific HOR leads to a characteristic geometrical pattern which may be responsible for individual microtubule to recognize a specific structure of centromere in each chromosome. PMID:18625244

  10. Higher-order Boltzmann machines and entropy bounds

    NASA Astrophysics Data System (ADS)

    Apolloni, Bruno; Battistini, Egidio; de Falco, Diego

    1999-07-01

    We examine some aspects of the interface area between mathematical statistics and statistical physics relevant to the study of Boltzmann machines. The Boltzmann machine learning algorithm is based on a variational principle (Gibbs' lemma for relative entropy). This fact suggests the possibility of a scheme of successive approximations: here we consider successive approximations parametrized by the order of many-body interactions among individual units. We prove bounds on the gain in relative entropy in the crucial step of adding, and estimating by Hebb's rule, a new parameter. We address the problem of providing, on the basis of local observations, upper and lower bounds on the entropy. While upper bounds are easily obtained by subadditivity, lower bounds involve localization of Hirschman bounds on a dual quantum system.

  11. Polarization and visibility of higher-order rainbows.

    PubMed

    Können, Gunther P

    2015-02-01

    The degree of polarization of rainbows of order k with k≥3 is bounded in the interval [75%, 78%], where 75% is the limit for k→∞. A polarization filter can improve the signal-to-background ratio of the third and fourth rainbows by a factor of 2, which may lift their visibilities in natural circumstances above the threshold of human visual perception. Under optimal circumstances, the latter may be true for the recently photographed green fingerprint of the fifth rainbow, even without the aid of a polarization filter. The prospects for observing the sixth rainbow are unclear. There exists a possibility that the signal of the natural seventh rainbow (appearing at 64° from the Sun) may be separated from its background if photographed under perfect conditions through a polarization filter. PMID:25967836

  12. A proposed ringing analysis model for higher order tether response

    SciTech Connect

    Natvig, B.J.

    1994-12-31

    The problem of high-frequency transient responses of Tension Leg Platforms, TLPs, under certain severe sea situations has been known for some time. Until recently, it was not known that this type of loading and response mechanism could produce tether loads of critical importance to the structural integrity of such structures. Presently, there is considerable ongoing discussion as to what causes tether ringing. NPD (1992) assembled a document where the views of the Norwegian Shelf operators and one Norwegian engineering company were summarized. At present there seems to be consensus that ringing, at least to a large extent, is caused by nonlinearities in the free surface variable wetting region of the TLP. Ringing is not predicted by linearized frequency domain analysis methods. There are a number of variable wetting contributions. Some of these are fairly obvious while others are less straight forward. A number of the contributions, of purely theoretical or engineering nature, identified to date are discussed in this paper. Based on this an intuitive method for ringing analysis is presented.

  13. Higher-order adaptive finite-element methods for Kohn–Sham density functional theory

    SciTech Connect

    Motamarri, P.; Nowak, M.R.; Leiter, K.; Knap, J.; Gavini, V.

    2013-11-15

    We present an efficient computational approach to perform real-space electronic structure calculations using an adaptive higher-order finite-element discretization of Kohn–Sham density-functional theory (DFT). To this end, we develop an a priori mesh-adaption technique to construct a close to optimal finite-element discretization of the problem. We further propose an efficient solution strategy for solving the discrete eigenvalue problem by using spectral finite-elements in conjunction with Gauss–Lobatto quadrature, and a Chebyshev acceleration technique for computing the occupied eigenspace. The proposed approach has been observed to provide a staggering 100–200-fold computational advantage over the solution of a generalized eigenvalue problem. Using the proposed solution procedure, we investigate the computational efficiency afforded by higher-order finite-element discretizations of the Kohn–Sham DFT problem. Our studies suggest that staggering computational savings—of the order of 1000-fold—relative to linear finite-elements can be realized, for both all-electron and local pseudopotential calculations, by using higher-order finite-element discretizations. On all the benchmark systems studied, we observe diminishing returns in computational savings beyond the sixth-order for accuracies commensurate with chemical accuracy, suggesting that the hexic spectral-element may be an optimal choice for the finite-element discretization of the Kohn–Sham DFT problem. A comparative study of the computational efficiency of the proposed higher-order finite-element discretizations suggests that the performance of finite-element basis is competing with the plane-wave discretization for non-periodic local pseudopotential calculations, and compares to the Gaussian basis for all-electron calculations to within an order of magnitude. Further, we demonstrate the capability of the proposed approach to compute the electronic structure of a metallic system containing 1688

  14. Higher-order adaptive finite-element methods for Kohn-Sham density functional theory

    NASA Astrophysics Data System (ADS)

    Motamarri, P.; Nowak, M. R.; Leiter, K.; Knap, J.; Gavini, V.

    2013-11-01

    We present an efficient computational approach to perform real-space electronic structure calculations using an adaptive higher-order finite-element discretization of Kohn-Sham density-functional theory (DFT). To this end, we develop an a priori mesh-adaption technique to construct a close to optimal finite-element discretization of the problem. We further propose an efficient solution strategy for solving the discrete eigenvalue problem by using spectral finite-elements in conjunction with Gauss-Lobatto quadrature, and a Chebyshev acceleration technique for computing the occupied eigenspace. The proposed approach has been observed to provide a staggering 100-200-fold computational advantage over the solution of a generalized eigenvalue problem. Using the proposed solution procedure, we investigate the computational efficiency afforded by higher-order finite-element discretizations of the Kohn-Sham DFT problem. Our studies suggest that staggering computational savings-of the order of 1000-fold-relative to linear finite-elements can be realized, for both all-electron and local pseudopotential calculations, by using higher-order finite-element discretizations. On all the benchmark systems studied, we observe diminishing returns in computational savings beyond the sixth-order for accuracies commensurate with chemical accuracy, suggesting that the hexic spectral-element may be an optimal choice for the finite-element discretization of the Kohn-Sham DFT problem. A comparative study of the computational efficiency of the proposed higher-order finite-element discretizations suggests that the performance of finite-element basis is competing with the plane-wave discretization for non-periodic local pseudopotential calculations, and compares to the Gaussian basis for all-electron calculations to within an order of magnitude. Further, we demonstrate the capability of the proposed approach to compute the electronic structure of a metallic system containing 1688 atoms using

  15. Higher order vortex gyrotropic modes in circular ferromagnetic nanodots.

    PubMed

    Ding, Junjia; Kakazei, Gleb N; Liu, Xinming; Guslienko, Konstantin Y; Adeyeye, Adekunle O

    2014-01-01

    Magnetic vortex that consists of an in-plane curling magnetization configuration and a needle-like core region with out-of-plane magnetization is known to be the ground state of geometrically confined submicron soft magnetic elements. Here magnetodynamics of relatively thick (50-100 nm) circular Ni80Fe20 dots were probed by broadband ferromagnetic resonance in the absence of external magnetic field. Spin excitation modes related to the thickness dependent vortex core gyrotropic dynamics were detected experimentally in the gigahertz frequency range. Both analytical theory and micromagnetic simulations revealed that these exchange dominated modes are flexure oscillations of the vortex core string with n = 0,1,2 nodes along the dot thickness. The intensity of the mode with n = 1 depends significantly on both dot thickness and diameter and in some cases is higher than the one of the uniform mode with n = 0. This opens promising perspectives in the area of spin transfer torque oscillators. PMID:24762659

  16. Structural order and disorder in Precambrian kerogens

    SciTech Connect

    Buseck, P.R.; Bo-Jun, H.; Miner, B.

    1988-01-01

    High-resolution transmission electron microscopy (HRTEM) has been used to examine the structures of a wide range of Precambrian kerogens from rocks with ages between 0.9 and 3.8 billion years. The authors find recognizable structural ordering in samples that show little or no evidence of crystallinity by powder X-ray diffraction measurements. A wide range in degree of ordering is evident in the HRTEM images. A rough correlation exists between the ordering displayed in the HRTEM images and both the sample ages and their H/C ratios. Many kerogen samples are structurally heterogeneous, possibly reflecting a variety of precursors, and source regions. The observed structural heterogeneities probably extend to other parameters; when isotopic and X-ray measurements can be made on the same scale as HRTEM images, similar scatter presumably will also be evident.

  17. Superintegrability and higher order integrals for quantum systems

    NASA Astrophysics Data System (ADS)

    Kalnins, E. G.; Kress, J. M.; Miller, W., Jr.

    2010-07-01

    We refine a method for finding a canonical form of symmetry operators of arbitrary order for the Schrödinger eigenvalue equation HΨ ≡ (Δ2 + V)Ψ = EΨ on any 2D Riemannian manifold, real or complex, that admits a separation of variables in some orthogonal coordinate system. The flat space equations with potentials V = α(x + iy)k - 1/(x - iy)k + 1 in Cartesian coordinates, and V = αr2 + β/r2cos 2kθ + γ/r2sin 2kθ (the Tremblay, Turbiner and Winternitz system) in polar coordinates, have each been shown to be classically superintegrable for all rational numbers k. We apply the canonical operator method to give a constructive proof that each of these systems is also quantum superintegrable for all rational k. We develop the classical analog of the quantum canonical form for a symmetry. It is clear that our methods will generalize to other Hamiltonian systems.

  18. Binary higher order neural networks for realizing Boolean functions.

    PubMed

    Zhang, Chao; Yang, Jie; Wu, Wei

    2011-05-01

    In order to more efficiently realize Boolean functions by using neural networks, we propose a binary product-unit neural network (BPUNN) and a binary π-ς neural network (BPSNN). The network weights can be determined by one-step training. It is shown that the addition " σ," the multiplication " π," and two kinds of special weighting operations in BPUNN and BPSNN can implement the logical operators " ∨," " ∧," and " ¬" on Boolean algebra 〈Z(2),∨,∧,¬,0,1〉 (Z(2)={0,1}), respectively. The proposed two neural networks enjoy the following advantages over the existing networks: 1) for a complete truth table of N variables with both truth and false assignments, the corresponding Boolean function can be realized by accordingly choosing a BPUNN or a BPSNN such that at most 2(N-1) hidden nodes are needed, while O(2(N)), precisely 2(N) or at most 2(N), hidden nodes are needed by existing networks; 2) a new network BPUPS based on a collaboration of BPUNN and BPSNN can be defined to deal with incomplete truth tables, while the existing networks can only deal with complete truth tables; and 3) the values of the weights are all simply -1 or 1, while the weights of all the existing networks are real numbers. Supporting numerical experiments are provided as well. Finally, we present the risk bounds of BPUNN, BPSNN, and BPUPS, and then analyze their probably approximately correct learnability. PMID:21427020

  19. Higher order Peregrine breathers solutions to the NLS equation

    NASA Astrophysics Data System (ADS)

    Gaillard, Pierre

    2015-09-01

    The solutions to the one dimensional focusing nonlinear Schrodinger equation (NLS) can be written as a product of an exponential depending on t by a quotient of two polynomials of degree N(N + 1) in x and t. These solutions depend on 2N - 2 parameters : when all these parameters are equal to 0, we obtain the famous Peregrine breathers which we call PN breathers. Between all quasi-rational solutions of rank N fixed by the condition that its absolute value tends to 1 at infinity and its highest maximum is located at point (x = 0,t = 0), the PN breather is distinguished by the fact that PN (0, 0) = 2N + 1. We construct Peregrine breathers of the rank N explicitly for N ≤ 11. We give figures of these PN breathers in the (x; t) plane; plots of the solutions PN (0; t), PN (x;0), never given for 6 < N < 11 are constructed in this work. It is the first time that the Peregrine breather of order 11 is explicitly constructed.

  20. Improvements to local projective noise reduction through higher order and multiscale refinements

    NASA Astrophysics Data System (ADS)

    Moore, Jack Murdoch; Small, Michael; Karrech, Ali

    2015-06-01

    The broad spectrum characteristic of signals from nonlinear systems obstructs noise reduction techniques developed for linear systems. Local projection was developed to reduce noise while preserving nonlinear deterministic structures, and a second order refinement to local projection which was proposed ten years ago does so particularly effectively. It involves adjusting the origin of the projection subspace to better accommodate the geometry of the attractor. This paper describes an analytic motivation for the enhancement from which follows further higher order and multiple scale refinements. However, the established enhancement is frequently as or more effective than the new filters arising from solely geometric considerations. Investigation of the way that measurement errors reinforce or cancel throughout the refined local projection procedure explains the special efficacy of the existing enhancement, and leads to a new second order refinement offering widespread gains. Different local projective filters are found to be best suited to different noise levels. At low noise levels, the optimal order increases as noise increases. At intermediate levels second order tends to be optimal, while at high noise levels prototypical local projection is most effective. The new higher order filters perform better relative to established filters for longer signals or signals corresponding to higher dimensional attractors.

  1. Improvements to local projective noise reduction through higher order and multiscale refinements.

    PubMed

    Moore, Jack Murdoch; Small, Michael; Karrech, Ali

    2015-06-01

    The broad spectrum characteristic of signals from nonlinear systems obstructs noise reduction techniques developed for linear systems. Local projection was developed to reduce noise while preserving nonlinear deterministic structures, and a second order refinement to local projection which was proposed ten years ago does so particularly effectively. It involves adjusting the origin of the projection subspace to better accommodate the geometry of the attractor. This paper describes an analytic motivation for the enhancement from which follows further higher order and multiple scale refinements. However, the established enhancement is frequently as or more effective than the new filters arising from solely geometric considerations. Investigation of the way that measurement errors reinforce or cancel throughout the refined local projection procedure explains the special efficacy of the existing enhancement, and leads to a new second order refinement offering widespread gains. Different local projective filters are found to be best suited to different noise levels. At low noise levels, the optimal order increases as noise increases. At intermediate levels second order tends to be optimal, while at high noise levels prototypical local projection is most effective. The new higher order filters perform better relative to established filters for longer signals or signals corresponding to higher dimensional attractors. PMID:26117108

  2. Influence of higher order modes on the beam stability in the high power superconducting proton linac

    NASA Astrophysics Data System (ADS)

    Schuh, Marcel; Gerigk, Frank; Tückmantel, Joachim; Welsch, Carsten P.

    2011-05-01

    Higher order modes (HOMs) can severely limit the operation of superconducting cavities in a linear accelerator with high beam current, high duty factor, and complex pulse structure. The full HOM spectrum has to be analyzed in order to identify potentially dangerous modes already during the design phase and to define their damping requirements. For this purpose a dedicated beam simulation code simulation of higher order mode dynamics (SMD) focused on beam-HOM interaction was developed, taking into account important effects like the HOM frequency spread, beam input jitter, different chopping patterns, as well as klystron and alignment errors. Here, SMD is used to investigate the influence of HOMs in detail in the superconducting proton linac at CERN and their potential to drive beam instabilities in the longitudinal and transverse plane.

  3. A refined higher-order theory and its finite element method for thick laminated plates

    NASA Astrophysics Data System (ADS)

    Fu, Xiaohua; Chen, Haoran; Wang, Zhenming

    1992-04-01

    An improved higher-order theory developed to enhance the accuracy of the shear deformation theory of thick laminated plates is presented. The Legendre polynomials are introduced in the approximate displacement distributions across the plate thickness, and an FEM is suggested from the original equations. The accuracy of the present theory is examined by applying it to bending problems of laminate plates solved by Pagano. The results are compared with 3D elasticity solutions, the second order shear deformation theory, and some other higher-order shear deformation theory solutions. The present theory shows the deflections and stress more accurately than that obtained from previous works in the structural analysis of laminated plates with a small span with respect to thickness.

  4. Higher-Order, Space-Time Adaptive Finite Volume Methods: Algorithms, Analysis and Applications

    SciTech Connect

    Minion, Michael

    2014-04-29

    The four main goals outlined in the proposal for this project were: 1. Investigate the use of higher-order (in space and time) finite-volume methods for fluid flow problems. 2. Explore the embedding of iterative temporal methods within traditional block-structured AMR algorithms. 3. Develop parallel in time methods for ODEs and PDEs. 4. Work collaboratively with the Center for Computational Sciences and Engineering (CCSE) at Lawrence Berkeley National Lab towards incorporating new algorithms within existing DOE application codes.

  5. Higher-order multipole amplitudes in charmonium radiative transitions

    NASA Astrophysics Data System (ADS)

    Artuso, M.; Blusk, S.; Khalil, S.; Mountain, R.; Randrianarivony, K.; Skwarnicki, T.; Stone, S.; Wang, J. C.; Zhang, L. M.; Bonvicini, G.; Cinabro, D.; Lincoln, A.; Smith, M. J.; Zhou, P.; Zhu, J.; Naik, P.; Rademacker, J.; Asner, D. M.; Edwards, K. W.; Reed, J.; Robichaud, A. N.; Tatishvili, G.; White, E. J.; Briere, R. A.; Vogel, H.; Onyisi, P. U. E.; Rosner, J. L.; Alexander, J. P.; Cassel, D. G.; Ehrlich, R.; Fields, L.; Galik, R. S.; Gibbons, L.; Gray, S. W.; Hartill, D. L.; Heltsley, B. K.; Hunt, J. M.; Kreinick, D. L.; Kuznetsov, V. E.; Ledoux, J.; Mahlke-Krüger, H.; Patterson, J. R.; Peterson, D.; Riley, D.; Ryd, A.; Sadoff, A. J.; Shi, X.; Stroiney, S.; Sun, W. M.; Yelton, J.; Rubin, P.; Lowrey, N.; Mehrabyan, S.; Selen, M.; Wiss, J.; Kornicer, M.; Mitchell, R. E.; Shepherd, M. R.; Tarbert, C. M.; Besson, D.; Pedlar, T. K.; Xavier, J.; Cronin-Hennessy, D.; Gao, K. Y.; Hietala, J.; Poling, R.; Zweber, P.; Dobbs, S.; Metreveli, Z.; Seth, K. K.; Tan, B. J. Y.; Tomaradze, A.; Brisbane, S.; Libby, J.; Martin, L.; Powell, A.; Spradlin, P.; Thomas, C.; Wilkinson, G.; Mendez, H.; Ge, J. Y.; Miller, D. H.; Shipsey, I. P. J.; Xin, B.; Adams, G. S.; Hu, D.; Moziak, B.; Napolitano, J.; Ecklund, K. M.; Insler, J.; Muramatsu, H.; Park, C. S.; Thorndike, E. H.; Yang, F.

    2009-12-01

    Using 24×106 ψ'≡ψ(2S) decays in CLEO-c, we have searched for higher multipole admixtures in electric-dipole-dominated radiative transitions in charmonia. We find good agreement between our data and theoretical predictions for magnetic quadrupole (M2) amplitudes in the transitions ψ'→γχc1,c2 and χc1,c2→γJ/ψ, in striking contrast to some previous measurements. Let b2J and a2J denote the normalized M2 amplitudes in the respective aforementioned decays, where the superscript J refers to the angular momentum of the χcJ. By performing unbinned maximum likelihood fits to full five-parameter angular distributions, we found the following values of M2 admixtures for Jχ=1: a2J=1=(-6.26±0.63±0.24)×10-2 and b2J=1=(2.76±0.73±0.23)×10-2, which agree well with theoretical expectations for a vanishing anomalous magnetic moment of the charm quark. For Jχ=2, if we fix the electric octupole (E3) amplitudes to zero as theory predicts for transitions between charmonium S states and P states, we find a2J=2=(-9.3±1.6±0.3)×10-2 and b2J=2=(1.0±1.3±0.3)×10-2. If we allow for E3 amplitudes we find, with a four-parameter fit, a2J=2=(-7.9±1.9±0.3)×10-2, b2J=2=(0.2±1.4±0.4)×10-2, a3J=2=(1.7±1.4±0.3)×10-2, and b3J=2=(-0.8±1.2±0.2)×10-2. We determine the ratios a2J=1/a2J=2=0.67-0.13+0.19 and a2J=1/b2J=1=-2.27-0.99+0.57, where the theoretical predictions are independent of the charmed quark magnetic moment and are a2J=1/a2J=2=0.676±0.071 and a2J=1/b2J=1=-2.27±0.16.

  6. A Higher-Order Neural Network Design for Improving Segmentation Performance in Medical Image Series

    NASA Astrophysics Data System (ADS)

    Selvi, Eşref; Selver, M. Alper; Güzeliş, Cüneyt; Dicle, Oǧuz

    2014-03-01

    Segmentation of anatomical structures from medical image series is an ongoing field of research. Although, organs of interest are three-dimensional in nature, slice-by-slice approaches are widely used in clinical applications because of their ease of integration with the current manual segmentation scheme. To be able to use slice-by-slice techniques effectively, adjacent slice information, which represents likelihood of a region to be the structure of interest, plays critical role. Recent studies focus on using distance transform directly as a feature or to increase the feature values at the vicinity of the search area. This study presents a novel approach by constructing a higher order neural network, the input layer of which receives features together with their multiplications with the distance transform. This allows higher-order interactions between features through the non-linearity introduced by the multiplication. The application of the proposed method to 9 CT datasets for segmentation of the liver shows higher performance than well-known higher order classification neural networks.

  7. Collapse of higher-order solute concentration moments in groundwater transport

    NASA Astrophysics Data System (ADS)

    Srzic, Veljko; Andricevic, Roko; Gotovac, Hrvoje; Cvetkovic, Vladimir

    2013-08-01

    In this paper, we use numerical simulations based on a Lagrangian framework to study contaminant transport through highly heterogeneous porous media due to advection and local diffusion (under local diffusion, we assume coupled effect of mechanical dispersion and molecular diffusion). The analysis of the concentration field is done for the case of a two-dimensional hydraulic conductivity domain representing the aquifer, with three log-conductivity structures that differ in spatial correlation. In addition to different conductivity structures, we focus our investigation on mild and highly heterogeneous porous media characterized by the values of hydraulic log-conductivity variance >(σY2>) being equal to 1 and 8. In the concentration moment analysis, we show that a linear relationship exists between higher-order to second-order normalized concentration moments on a log-log scale up to the fourth-order moment. This leads to the important finding that moments of a higher than the second order can be derived based on information about the first two concentration moments only. Such a property has been observed previously for boundary-layer water channels, wind tunnels, and turbulent diffusion in open terrain and laboratory experiments. Normalized moments are shown to collapse for different types of hydraulic conductivity structures, Peclet (Pe) numbers and σY2 values. In the case of local diffusion absence, a linear log-log relationship is derived analytically and is set as a lower limit. The deviation from the lower limit is explained to be predominantly caused by the local diffusion, which needs time to evolve. In the case of local diffusion presence, we define the moment deriving function (MDF) to describe the linear log-log relationship between higher-order concentration moments to the second-order normalized one. Finally, the comparison between numerical results and those obtained from the Columbus Air Force Base Macrodispersion Experiment (MADE 1) is used to

  8. Radiation Heat Transfer Between Diffuse-Gray Surfaces Using Higher Order Finite Elements

    NASA Technical Reports Server (NTRS)

    Gould, Dana C.

    2000-01-01

    This paper presents recent work on developing methods for analyzing radiation heat transfer between diffuse-gray surfaces using p-version finite elements. The work was motivated by a thermal analysis of a High Speed Civil Transport (HSCT) wing structure which showed the importance of radiation heat transfer throughout the structure. The analysis also showed that refining the finite element mesh to accurately capture the temperature distribution on the internal structure led to very large meshes with unacceptably long execution times. Traditional methods for calculating surface-to-surface radiation are based on assumptions that are not appropriate for p-version finite elements. Two methods for determining internal radiation heat transfer are developed for one and two-dimensional p-version finite elements. In the first method, higher-order elements are divided into a number of sub-elements. Traditional methods are used to determine radiation heat flux along each sub-element and then mapped back to the parent element. In the second method, the radiation heat transfer equations are numerically integrated over the higher-order element. Comparisons with analytical solutions show that the integration scheme is generally more accurate than the sub-element method. Comparison to results from traditional finite elements shows that significant reduction in the number of elements in the mesh is possible using higher-order (p-version) finite elements.

  9. Disruption of Broca's Area Alters Higher-order Chunking Processing during Perceptual Sequence Learning.

    PubMed

    Alamia, Andrea; Solopchuk, Oleg; D'Ausilio, Alessandro; Van Bever, Violette; Fadiga, Luciano; Olivier, Etienne; Zénon, Alexandre

    2016-03-01

    Because Broca's area is known to be involved in many cognitive functions, including language, music, and action processing, several attempts have been made to propose a unifying theory of its role that emphasizes a possible contribution to syntactic processing. Recently, we have postulated that Broca's area might be involved in higher-order chunk processing during implicit learning of a motor sequence. Chunking is an information-processing mechanism that consists of grouping consecutive items in a sequence and is likely to be involved in all of the aforementioned cognitive processes. Demonstrating a contribution of Broca's area to chunking during the learning of a nonmotor sequence that does not involve language could shed new light on its function. To address this issue, we used offline MRI-guided TMS in healthy volunteers to disrupt the activity of either the posterior part of Broca's area (left Brodmann's area [BA] 44) or a control site just before participants learned a perceptual sequence structured in distinct hierarchical levels. We found that disruption of the left BA 44 increased the processing time of stimuli representing the boundaries of higher-order chunks and modified the chunking strategy. The current results highlight the possible role of the left BA 44 in building up effector-independent representations of higher-order events in structured sequences. This might clarify the contribution of Broca's area in processing hierarchical structures, a key mechanism in many cognitive functions, such as language and composite actions. PMID:26765778

  10. A higher-order nonlocal elasticity and strain gradient theory and its applications in wave propagation

    NASA Astrophysics Data System (ADS)

    Lim, C. W.; Zhang, G.; Reddy, J. N.

    2015-05-01

    In recent years there have been many papers that considered the effects of material length scales in the study of mechanics of solids at micro- and/or nano-scales. There are a number of approaches and, among them, one set of papers deals with Eringen's differential nonlocal model and another deals with the strain gradient theories. The modified couple stress theory, which also accounts for a material length scale, is a form of a strain gradient theory. The large body of literature that has come into existence in the last several years has created significant confusion among researchers about the length scales that these various theories contain. The present paper has the objective of establishing the fact that the length scales present in nonlocal elasticity and strain gradient theory describe two entirely different physical characteristics of materials and structures at nanoscale. By using two principle kernel functions, the paper further presents a theory with application examples which relates the classical nonlocal elasticity and strain gradient theory and it results in a higher-order nonlocal strain gradient theory. In this theory, a higher-order nonlocal strain gradient elasticity system which considers higher-order stress gradients and strain gradient nonlocality is proposed. It is based on the nonlocal effects of the strain field and first gradient strain field. This theory intends to generalize the classical nonlocal elasticity theory by introducing a higher-order strain tensor with nonlocality into the stored energy function. The theory is distinctive because the classical nonlocal stress theory does not include nonlocality of higher-order stresses while the common strain gradient theory only considers local higher-order strain gradients without nonlocal effects in a global sense. By establishing the constitutive relation within the thermodynamic framework, the governing equations of equilibrium and all boundary conditions are derived via the variational

  11. Higher order accurate partial implicitization: An unconditionally stable fourth-order-accurate explicit numerical technique

    NASA Technical Reports Server (NTRS)

    Graves, R. A., Jr.

    1975-01-01

    The previously obtained second-order-accurate partial implicitization numerical technique used in the solution of fluid dynamic problems was modified with little complication to achieve fourth-order accuracy. The Von Neumann stability analysis demonstrated the unconditional linear stability of the technique. The order of the truncation error was deduced from the Taylor series expansions of the linearized difference equations and was verified by numerical solutions to Burger's equation. For comparison, results were also obtained for Burger's equation using a second-order-accurate partial-implicitization scheme, as well as the fourth-order scheme of Kreiss.

  12. Generalized Flows for Optimal Inference in Higher Order MRF-MAP.

    PubMed

    Arora, Chetan; Banerjee, Subhashis; Kalra, Prem Kumar; Maheshwari, S N

    2015-07-01

    Use of higher order clique potentials in MRF-MAP problems has been limited primarily because of the inefficiencies of the existing algorithmic schemes. We propose a new combinatorial algorithm for computing optimal solutions to 2 label MRF-MAP problems with higher order clique potentials. The algorithm runs in time O(2(k)n(3)) in the worst case (k is size of clique and n is the number of pixels). A special gadget is introduced to model flows in a higher order clique and a technique for building a flow graph is specified. Based on the primal dual structure of the optimization problem, the notions of the capacity of an edge and a cut are generalized to define a flow problem. We show that in this flow graph, when the clique potentials are submodular, the max flow is equal to the min cut, which also is the optimal solution to the problem. We show experimentally that our algorithm provides significantly better solutions in practice and is hundreds of times faster than solution schemes like Dual Decomposition [1], TRWS [2] and Reduction [3], [4], [5]. The framework represents a significant advance in handling higher order problems making optimal inference practical for medium sized cliques. PMID:26352442

  13. Generation and manipulation of higher order Fano resonances in plasmonic nanodisks with a built-in missing sectorial slice

    NASA Astrophysics Data System (ADS)

    Liu, Tingzhuo; Li, Junna; Gao, Fei; Han, Qingyan; Liu, Shengzhong

    2013-11-01

    Fano resonances have been achieved in a variety of complex plasmonic nanostructures. Here we propose a novel planar structure supporting higher order Fano resonances, a plasmonic nanodisk with a built-in missing sectorial slice whose slice angle varies from 0 to 360°. The numerical results reveal that higher order Fano resonances can be generated in the visible wavelength range when the slice angle locates in a certain range in this reduced-symmetry structure. Such higher order Fano resonances result from the coupling between the dipolar mode supported by the edge of the built-in missing slice and the multipolar ring modes. Furthermore, the effects of dimension and ring width of this structure on the spectral positions and intensities of the higher order Fano resonances are also studied. The line shapes of Fano resonances can be tuned flexibly by modifying the geometrical parameters of this structure.

  14. Cross-phase modulational instability in an elliptical birefringent fiber with higher order nonlinearity and dispersion

    NASA Astrophysics Data System (ADS)

    Ganapathy, R.; Kuriakose, V. C.

    2002-04-01

    We obtain conditions for the occurrence of cross-phase modulational instability in the normal dispersion regime for the coupled higher order nonlinear Schrödinger equation with higher order dispersion and nonlinear terms.

  15. Controlled generation of higher-order Poincaré sphere beams from a laser

    NASA Astrophysics Data System (ADS)

    Naidoo, Darryl; Roux, Filippus S.; Dudley, Angela; Litvin, Igor; Piccirillo, Bruno; Marrucci, Lorenzo; Forbes, Andrew

    2016-05-01

    The angular momentum of light can be described by positions on a higher-order Poincaré sphere, where superpositions of spin and orbital angular momentum states give rise to laser beams that have many applications, from microscopy to materials processing. Many techniques exist to create such beams but none so far allow their creation at the source. Here we report on a new class of laser that is able to generate all states on the higher-order Poincaré sphere. We exploit geometric phase control inside a laser cavity to map polarization to orbital angular momentum, demonstrating that the orbital angular momentum degeneracy of a standard laser cavity may be broken, producing pure orbital angular momentum beams, and that generalized vector vortex beams may be created with high purity at the source. This work paves the way to new lasers for structured light based on intracavity geometric phase control.

  16. Higher-order laser beam scintillation in weakly turbulent marine atmospheric medium.

    PubMed

    Baykal, Yahya

    2016-04-01

    The atmosphere above the sea or ocean, known as the marine atmosphere, affects optical waves propagating through it in a different manner than the atmosphere above land. Like other system design parameters, intensity fluctuations of laser light propagating in marine atmosphere, quantified by the scintillation index, also show different variations. The on-axis scintillations of higher-order laser beams are formulated and evaluated when such excitations are employed in a weakly turbulent marine atmospheric medium. Variations of the scintillation index with respect to the changes in the Gaussian beam size of the higher-order mode, link length, wavelength, and structure constant are reported. Our results can be used in the design of an optical wireless communication link design operating in marine atmospheres. PMID:27140788

  17. An expansion formula with higher-order derivatives for fractional operators of variable order.

    PubMed

    Almeida, Ricardo; Torres, Delfim F M

    2013-01-01

    We obtain approximation formulas for fractional integrals and derivatives of Riemann-Liouville and Marchaud types with a variable fractional order. The approximations involve integer-order derivatives only. An estimation for the error is given. The efficiency of the approximation method is illustrated with examples. As applications, we show how the obtained results are useful to solve differential equations, and problems of the calculus of variations that depend on fractional derivatives of Marchaud type. PMID:24319382

  18. Electroweak higher-order effects and theoretical uncertainties in deep-inelastic neutrino scattering

    SciTech Connect

    Diener, K.-P.O.; Dittmaier, S.; Hollik, W.

    2005-11-01

    A previous calculation of electroweak O({alpha}) corrections to deep-inelastic neutrino scattering, as e.g. measured by NuTeV and NOMAD, is supplemented by higher-order effects. In detail, we take into account universal two-loop effects from {delta}{alpha} and {delta}{rho} as well as higher-order final-state photon radiation off muons in the structure function approach. Moreover, we make use of the recently released O({alpha})-improved parton distributions MRST2004QED and identify the relevant QED factorization scheme, which is DIS-like. As a technical by-product, we describe slicing and subtraction techniques for an efficient calculation of a new type of real corrections that are induced by the generated photon distribution. A numerical discussion of the higher-order effects suggests that the remaining theoretical uncertainty from unknown electroweak corrections is dominated by nonuniversal two-loop effects and is of the order 0.0003 when translated into a shift in sin{sup 2}{theta}{sub W}=1-M{sub W}{sup 2}/M{sub Z}{sup 2}. The O({alpha}) corrections implicitly included in the parton distributions lead to a shift of about 0.0004.

  19. Assessing School Work Culture: A Higher-Order Analysis and Strategy.

    ERIC Educational Resources Information Center

    Johnson, William L.; Johnson, Annabel M.; Zimmerman, Kurt J.

    This paper reviews a work culture productivity model and reports the development of a work culture instrument based on the culture productivity model. Higher order principal components analysis was used to assess work culture, and a third-order factor analysis shows how the first-order factors group into higher-order factors. The school work…

  20. Efficient Reformulation of the Thermoelastic Higher-order Theory for Fgms

    NASA Technical Reports Server (NTRS)

    Bansal, Yogesh; Pindera, Marek-Jerzy; Arnold, Steven M. (Technical Monitor)

    2002-01-01

    Functionally graded materials (FGMs) are characterized by spatially variable microstructures which are introduced to satisfy given performance requirements. The microstructural gradation gives rise to continuously or discretely changing material properties which complicate FGM analysis. Various techniques have been developed during the past several decades for analyzing traditional composites and many of these have been adapted for the analysis of FGMs. Most of the available techniques use the so-called uncoupled approach in order to analyze graded structures. These techniques ignore the effect of microstructural gradation by employing specific spatial material property variations that are either assumed or obtained by local homogenization. The higher-order theory for functionally graded materials (HOTFGM) is a coupled approach developed by Aboudi et al. (1999) which takes the effect of microstructural gradation into consideration and does not ignore the local-global interaction of the spatially variable inclusion phase(s). Despite its demonstrated utility, however, the original formulation of the higher-order theory is computationally intensive. Herein, an efficient reformulation of the original higher-order theory for two-dimensional elastic problems is developed and validated. The use of the local-global conductivity and local-global stiffness matrix approach is made in order to reduce the number of equations involved. In this approach, surface-averaged quantities are the primary variables which replace volume-averaged quantities employed in the original formulation. The reformulation decreases the size of the global conductivity and stiffness matrices by approximately sixty percent. Various thermal, mechanical, and combined thermomechanical problems are analyzed in order to validate the accuracy of the reformulated theory through comparison with analytical and finite-element solutions. The presented results illustrate the efficiency of the reformulation and its

  1. Molecular behavior of DNA origami in higher-order self-assembly.

    PubMed

    Li, Zhe; Liu, Minghui; Wang, Lei; Nangreave, Jeanette; Yan, Hao; Liu, Yan

    2010-09-29

    DNA-based self-assembly is a unique method for achieving higher-order molecular architectures made possible by the fact that DNA is a programmable information-coding polymer. In the past decade, two main types of DNA nanostructures have been developed: branch-shaped DNA tiles with small dimensions (commonly up to ∼20 nm) and DNA origami tiles with larger dimensions (up to ∼100 nm). Here we aimed to determine the important factors involved in the assembly of DNA origami superstructures. We constructed a new series of rectangular-shaped DNA origami tiles in which parallel DNA helices are arranged in a zigzag pattern when viewed along the DNA helical axis, a design conceived in order to relax an intrinsic global twist found in the original planar, rectangular origami tiles. Self-associating zigzag tiles were found to form linear arrays in both diagonal directions, while planar tiles showed significant growth in only one direction. Although the series of zigzag tiles were designed to promote two-dimensional array formation, one-dimensional linear arrays and tubular structures were observed instead. We discovered that the dimensional aspect ratio of the origami unit tiles and intertile connection design play important roles in determining the final products, as revealed by atomic force microscopy imaging. This study provides insight into the formation of higher-order structures from self-assembling DNA origami tiles, revealing their unique behavior in comparison with conventional DNA tiles having smaller dimensions. PMID:20825190

  2. Molecular Behavior of DNA Origami in Higher-Order Self-Assembly

    SciTech Connect

    Li, Zhe; Liu, Minghui; Lei, Wang; Nangreave, Jeanette; Yan, Hao; Liu, Yan

    2010-09-08

    DNA-based self-assembly is a unique method for achieving higher-order molecular architectures made possible by the fact that DNA is a programmable information-coding polymer. In the past decade, two main types of DNA nanostructures have been developed: branch-shaped DNA tiles with small dimensions (commonly up to ~20 nm) and DNA origami tiles with larger dimensions (up to ~100 nm). Here we aimed to determine the important factors involved in the assembly of DNA origami superstructures. We constructed a new series of rectangular-shaped DNA origami tiles in which parallel DNA helices are arranged in a zigzag pattern when viewed along the DNA helical axis, a design conceived in order to relax an intrinsic global twist found in the original planar, rectangular origami tiles. Self-associating zigzag tiles were found to form linear arrays in both diagonal directions, while planar tiles showed significant growth in only one direction. Although the series of zigzag tiles were designed to promote two-dimensional array formation, one-dimensional linear arrays and tubular structures were observed instead. We discovered that the dimensional aspect ratio of the origami unit tiles and intertile connection design play important roles in determining the final products, as revealed by atomic force microscopy imaging. This study provides insight into the formation of higher-order structures from self-assembling DNA origami tiles, revealing their unique behavior in comparison with conventional DNA tiles having smaller dimensions.

  3. Transverse vibrations of shear-deformable beams using a general higher order theory

    NASA Technical Reports Server (NTRS)

    Kosmatka, J. B.

    1993-01-01

    A general higher order theory is developed to study the static and vibrational behavior of beam structures having an arbitrary cross section that utilizes both out-of-plane shear-dependent warping and in-plane (anticlastic) deformations. The equations of motion are derived via Hamilton's principle, where the full 3D constitutive relations are used. A simplified version of the general higher-order theory is also presented for beams having an arbitrary cross section that includes out-of-plane shear deformation but assumes that stresses within the cross section and in-plane deformations are negligible. This simplified model, which is accurate for long to moderately short wavelengths, offers substantial improvements over existing higher order theories that are limited to beams with thin rectangular cross sections. The current approach will be very useful in the study of thin-wall closed-cell beams such as airfoil-type sections where the magnitude of shear-related cross-sectional warping is significant.

  4. Constructing Higher-Order DNA Nanoarchitectures with Highly Purified DNA Nanocages.

    PubMed

    Xing, Shu; Jiang, Dawei; Li, Fan; Li, Jiang; Li, Qian; Huang, Qing; Guo, Linjie; Xia, Jiaoyun; Shi, Jiye; Fan, Chunhai; Zhang, Lan; Wang, Lihua

    2015-06-24

    DNA nanostructures have attracted great attention due to their precisely controllable geometry and great potential in various areas including bottom-up self-assembly. However, construction of higher-order DNA nanoarchitectures with individual DNA nanostructures is often hampered with the purity and quantity of these "bricks". Here, we introduced size exclusion chromatography (SEC) to prepare highly purified tetrahedral DNA nanocages in large scale and demonstrated that precise quantification of DNA nanocages was the key to the formation of higher-order DNA nanoarchitectures. We successfully purified a series of DNA nanocages with different sizes, including seven DNA tetrahedra with different edge lengths (7, 10, 13, 17, 20, 26, 30 bp) and one trigonal bipyramid with a 20-bp edge. These highly purified and aggregation-free DNA nanocages could be self-assembled into higher-order DNA nanoarchitectures with extraordinarily high yields (98% for dimer and 95% for trimer). As a comparison, unpurified DNA nanocages resulted in low yield of 14% for dimer and 12% for trimer, respectively. AFM images cleraly presented the characteristic structure of monomer, dimer and trimer, impling the purified DNA nanocages well-formed the designed nanoarchitectures. Therefore, we have demonstrated that highly purified DNA nanocages are excellent "bricks" for DNA nanotechnology and show great potential in various applications of DNA nanomaterials. PMID:25345465

  5. The usefulness of higher-order constitutive relations for describing the Knudsen layer.

    SciTech Connect

    Gallis, Michail A.; Lockerby, Duncan A.; Reese, Jason M.

    2005-03-01

    The Knudsen layer is an important rarefaction phenomenon in gas flows in and around microdevices. Its accurate and efficient modeling is of critical importance in the design of such systems and in predicting their performance. In this paper we investigate the potential that higher-order continuum equations may have to model the Knudsen layer, and compare their predictions to high-accuracy DSMC (direct simulation Monte Carlo) data, as well as a standard result from kinetic theory. We find that, for a benchmark case, the most common higher-order continuum equation sets (Grad's 13 moment, Burnett, and super-Burnett equations) cannot capture the Knudsen layer. Variants of these equation families have, however, been proposed and some of them can qualitatively describe the Knudsen layer structure. To make quantitative comparisons, we obtain additional boundary conditions (needed for unique solutions to the higher-order equations) from kinetic theory. However, we find the quantitative agreement with kinetic theory and DSMC data is only slight.

  6. Impedance Eduction in Ducts with Higher-Order Modes and Flow

    NASA Technical Reports Server (NTRS)

    Watson, Willie R.; Jones, Michael G.

    2009-01-01

    An impedance eduction technique, previously validated for ducts with plane waves at the source and duct termination planes, has been extended to support higher-order modes at these locations. Inputs for this method are the acoustic pressures along the source and duct termination planes, and along a microphone array located in a wall either adjacent or opposite to the test liner. A second impedance eduction technique is then presented that eliminates the need for the microphone array. The integrity of both methods is tested using three sound sources, six Mach numbers, and six selected frequencies. Results are presented for both a hardwall and a test liner (with known impedance) consisting of a perforated plate bonded to a honeycomb core. The primary conclusion of the study is that the second method performs well in the presence of higher-order modes and flow. However, the first method performs poorly when most of the microphones are located near acoustic pressure nulls. The negative effects of the acoustic pressure nulls can be mitigated by a judicious choice of the mode structure in the sound source. The paper closes by using the first impedance eduction method to design a rectangular array of 32 microphones for accurate impedance eduction in the NASA LaRC Curved Duct Test Rig in the presence of expected measurement uncertainties, higher order modes, and mean flow.

  7. On the polarization of non-Gaussian optical quantum field: Higher-order optical-polarization

    SciTech Connect

    Singh, Ravi S.; Prakash, Hari

    2013-06-15

    Polarization of light signifies transversal, anisotropic and asymmetrical statistical properties of electromagnetic radiation about the direction of propagation. Traditionally, optical-polarization is characterized by Stokes’ theory susceptible to be insufficient in assessing the polarization structure of optical quantum fields and, also, does not decipher the twin characteristic polarization parameters (‘ratio of real amplitudes and difference in phases’). An alternative way, in the spirit of classical description of optical-polarization, is introduced which can be generalized to deal higher-order polarization of quantum light, particularly, prepared in non-Gaussian Schrodinger Cat or Cat-like states and entangled bi-modal coherent states. On account of pseudo mono-modal or multi-modal nature of such optical quantum field, higher-order polarization is seen to be highly sensitive to the basis of description. -- Highlights: •We have generalized the usual concept of optical-polarization. •A concept of higher-order optical-polarization is introduced. •This concept is applied to compute the polarization-parameters of non-Gaussian Optical field. •To the best of our knowledge, no study is performed which investigates such optical quantum field.

  8. Constructing higher order DNA origami arrays using DNA junctions of anti-parallel/parallel double crossovers

    NASA Astrophysics Data System (ADS)

    Ma, Zhipeng; Park, Seongsu; Yamashita, Naoki; Kawai, Kentaro; Hirai, Yoshikazu; Tsuchiya, Toshiyuki; Tabata, Osamu

    2016-06-01

    DNA origami provides a versatile method for the construction of nanostructures with defined shape, size and other properties; such nanostructures may enable a hierarchical assembly of large scale architecture for the placement of other nanomaterials with atomic precision. However, the effective use of these higher order structures as functional components depends on knowledge of their assembly behavior and mechanical properties. This paper demonstrates construction of higher order DNA origami arrays with controlled orientations based on the formation of two types of DNA junctions: anti-parallel and parallel double crossovers. A two-step assembly process, in which preformed rectangular DNA origami monomer structures themselves undergo further self-assembly to form numerically unlimited arrays, was investigated to reveal the influences of assembly parameters. AFM observations showed that when parallel double crossover DNA junctions are used, the assembly of DNA origami arrays occurs with fewer monomers than for structures formed using anti-parallel double crossovers, given the same assembly parameters, indicating that the configuration of parallel double crossovers is not energetically preferred. However, the direct measurement by AFM force-controlled mapping shows that both DNA junctions of anti-parallel and parallel double crossovers have homogeneous mechanical stability with any part of DNA origami.

  9. Boosting brain connectome classification accuracy in Alzheimer's disease using higher-order singular value decomposition

    PubMed Central

    Zhan, Liang; Liu, Yashu; Wang, Yalin; Zhou, Jiayu; Jahanshad, Neda; Ye, Jieping; Thompson, Paul M.

    2015-01-01

    Alzheimer's disease (AD) is a progressive brain disease. Accurate detection of AD and its prodromal stage, mild cognitive impairment (MCI), are crucial. There is also a growing interest in identifying brain imaging biomarkers that help to automatically differentiate stages of Alzheimer's disease. Here, we focused on brain structural networks computed from diffusion MRI and proposed a new feature extraction and classification framework based on higher order singular value decomposition and sparse logistic regression. In tests on publicly available data from the Alzheimer's Disease Neuroimaging Initiative, our proposed framework showed promise in detecting brain network differences that help in classifying different stages of Alzheimer's disease. PMID:26257601

  10. Higher Order Thinking Skills among Secondary School Students in Science Learning

    ERIC Educational Resources Information Center

    Saido, Gulistan Mohammed; Siraj, Saedah; Bin Nordin, Abu Bakar; Al Amedy, Omed Saadallah

    2015-01-01

    A central goal of science education is to help students to develop their higher order thinking skills to enable them to face the challenges of daily life. Enhancing students' higher order thinking skills is the main goal of the Kurdish Science Curriculum in the Iraqi-Kurdistan region. This study aimed at assessing 7th grade students' higher order…

  11. Testing higher-order Lagrangian perturbation theory against numerical simulation. 1: Pancake models

    NASA Technical Reports Server (NTRS)

    Buchert, T.; Melott, A. L.; Weiss, A. G.

    1993-01-01

    We present results showing an improvement of the accuracy of perturbation theory as applied to cosmological structure formation for a useful range of quasi-linear scales. The Lagrangian theory of gravitational instability of an Einstein-de Sitter dust cosmogony investigated and solved up to the third order is compared with numerical simulations. In this paper we study the dynamics of pancake models as a first step. In previous work the accuracy of several analytical approximations for the modeling of large-scale structure in the mildly non-linear regime was analyzed in the same way, allowing for direct comparison of the accuracy of various approximations. In particular, the Zel'dovich approximation (hereafter ZA) as a subclass of the first-order Lagrangian perturbation solutions was found to provide an excellent approximation to the density field in the mildly non-linear regime (i.e. up to a linear r.m.s. density contrast of sigma is approximately 2). The performance of ZA in hierarchical clustering models can be greatly improved by truncating the initial power spectrum (smoothing the initial data). We here explore whether this approximation can be further improved with higher-order corrections in the displacement mapping from homogeneity. We study a single pancake model (truncated power-spectrum with power-spectrum with power-index n = -1) using cross-correlation statistics employed in previous work. We found that for all statistical methods used the higher-order corrections improve the results obtained for the first-order solution up to the stage when sigma (linear theory) is approximately 1. While this improvement can be seen for all spatial scales, later stages retain this feature only above a certain scale which is increasing with time. However, third-order is not much improvement over second-order at any stage. The total breakdown of the perturbation approach is observed at the stage, where sigma (linear theory) is approximately 2, which corresponds to the

  12. Achieving Higher Energies via Passively Driven X-band Structures

    NASA Astrophysics Data System (ADS)

    Sipahi, Taylan; Sipahi, Nihan; Milton, Stephen; Biedron, Sandra

    2014-03-01

    Due to their higher intrinsic shunt impedance X-band accelerating structures significant gradients with relatively modest input powers, and this can lead to more compact particle accelerators. At the Colorado State University Accelerator Laboratory (CSUAL) we would like to adapt this technology to our 1.3 GHz L-band accelerator system using a passively driven 11.7 GHz traveling wave X-band configuration that capitalizes on the high shunt impedances achievable in X-band accelerating structures in order to increase our overall beam energy in a manner that does not require investment in an expensive, custom, high-power X-band klystron system. Here we provide the design details of the X-band structures that will allow us to achieve our goal of reaching the maximum practical net potential across the X-band accelerating structure while driven solely by the beam from the L-band system.

  13. Even and Odd Charge Coherent States: Higher-Order Nonclassical Properties and Generation Scheme

    NASA Astrophysics Data System (ADS)

    Duc, Truong Minh; Dinh, Dang Huu; Dat, Tran Quang

    2016-06-01

    We examine the higher-order nonclassical properties of the even and odd charge coherent states as well as proposing a scheme to generate these states whose modes can freely travel in open space. We show that the even and odd charge coherent states exhibit both higher-order antibunching and higher-order squeezing. While the two-mode higher-order antibunching occurs in any order and essentially depends on the charge number, the two-mode higher-order squeezing appears only in the even orders. We also prove that these states are genuinely entangled, and they can be generated by means of cross-Kerr media, beam splitters, phase shifts and threshold detectors. We find that the fidelity and the corresponding success probability to generate these states are dependent on the correlative parameters.

  14. Higher-order flux difference splitting schemes for the Euler equations using upstream interpolations

    NASA Technical Reports Server (NTRS)

    Yang, J. Y.

    1986-01-01

    A class of explicit two time-level, 2p + 1 space-point, (2p 1)-th order, upwind-biased flux difference splitting schemes are proposed for the numerical advection based on Lagrange's interpolation, and the method is an accord with the physical domain of dependence. A normalized Jacobian coefficient matrix is introduced to convert the schemes to hyperbolic systems of conservation laws, and approaches to make the higher-order schemes total variation stable are discussed. Accuracy and stability of the present schemes are examined, and implicit total variation diminishing schemes are developed for steady-state calculations.Application to gasdynamic problems for both steady and unsteady flows covering a wide range of Mach numbers is considered, and results for a blast wave passing a cylinder, and head-on collision of two blast waves over a circular arc, are presented. The flow patterns were found to be symmetric, and good resolution of flow structures was obtained.

  15. Double Quarter Wave Crab Cavity Field Profile Analysis and Higher Order Mode Characterization

    SciTech Connect

    Marques, Carlos; Xiao, B. P.; Belomestnykh, S.

    2014-06-01

    The Large Hadron Collider (LHC) is underway for a major upgrade to increase its luminosity by an order of magnitude beyond its original design specifications. This novel machine configuration known as the High Luminosity LHC (HL-LHC) will rely on various innovative technologies including very compact and ultra-precise superconducting crab cavities for beam rotation. A double quarter wave crab cavity (DQWCC) has been designed at Brookhaven National Laboratory for the HL-LHC. This cavity as well as the structural support components were fabricated and assembled at Niowave. The field profile of the crabbing mode for the DQWCC was investigated using a phase shift bead pulling technique and compared with simulated results to ensure proper operation or discover discrepancies from modeled results and/or variation in fabrication tolerances. Higher-Order Mode (HOM) characterization was also performed and correlated with simulations.

  16. Higher-order corrections to broadband electrostatic shock noise in auroral zone

    NASA Astrophysics Data System (ADS)

    Abdelwahed, H. G.

    2015-09-01

    Nonlinear shock wave structures in collisionless unmagnetized viscous plasma comprised of fluid of cold electron and nonisothermal hot electrons obeying superthermal electron distribution and ions in stationary state are examined. For nonlinear electron acoustic shock waves, a reductive perturbation method was applied to deduce the Burger equation in terms of first order potential. When the shock wave amplitude was enlarged, the steepness and the velocity of the wave sidetrack from Burger equation. We have to resume our calculations to obtain the Burger-type equation with higher order dissipation. The collective solution for the resulting equations has been given by the renormalization method. The effects of spectral index κ, the ratio of the initial equilibrium density of cold electron to hot electrons β, and the kinematic viscosity coefficient η on the broadband electrostatic shock noise in aurora are also argued.

  17. Spinor helicity structures in higher spin theories

    NASA Astrophysics Data System (ADS)

    Ananth, Sudarshan

    2012-11-01

    It is shown that the coefficient of the cubic interaction vertex, in higher spin Lagrangians, has a very simple form when written in terms of spinor helicity products. The result for a higher-spin field, of spin λ, is equal to the corresponding Yang-Mills coefficient raised to the power λ. Among other things, this suggests perturbative ties, similar to the KLT relations, between higher spin theories and pure Yang-Mills. This result is obtained in four-dimensional flat spacetime.

  18. The impedance problem of wave diffraction by a strip with higher order boundary conditions

    SciTech Connect

    Castro, L. P.; Simões, A. M.

    2013-10-17

    This work is devoted to analyse an impedance boundary-transmission problem for the Helmholtz equation originated by a problem of wave diffraction by an infinite strip with higher order imperfect boundary conditions. A constructive approach of operator relations is built, which allows a transparent interpretation of the problem in an operator theory framework. In particular, different types of operator relations are exhibited for different types of operators acting between Lebesgue and Sobolev spaces on a finite interval and the positive half-line. All this has consequences in the understanding of the structure of this type of problems. In particular, a Fredholm characterization of the problem is obtained in terms of the initial space order parameters. At the request of the author and the Proceedings Editor the above article has been replaced with a corrected version. The original PDF file supplied to AIP Publishing contained an error in the title of the article. The original title appeared as: 'The Impedance Problem of Wave Diffraction by a trip with Higher Order Boundary Conditions.' This article has been replaced and the title now appears correctly online. The corrected article was published on 8 November 2013.

  19. Higher-order exchange interactions leading to metamagnetism in FeRh

    NASA Astrophysics Data System (ADS)

    Barker, Joseph; Chantrell, Roy W.

    2015-09-01

    The origin of the metamagnetic antiferromagnetic-ferromagnetic phase transition of FeRh is a subject of debate. Competing explanations invoke magnetovolume effects or a purely thermodynamic transition within the spin system. It is experimentally difficult to observe the changes in the magnetic system and the lattice simultaneously, leading to conflicting evidence over which mechanism causes the phase transition. A noncollinear electronic structure study by Mryasov [Phase Transitions 78, 197 (2005), 10.1080/01411590412331316591] showed that nonlinear behavior of the Rh moment leads to higher-order exchange terms in FeRh. Using atomistic spin dynamics, we show that the phase transition can occur due to the competition between bilinear and the higher-order four spin exchange terms in an effective spin Hamiltonian. The phase transition we see is of first order and shows thermal hysteresis in agreement with experimental observations. Simulating subpicosecond laser heating, we show an agreement with pump-probe experiments with a ferromagnetic response on a picosecond time scale.

  20. From higher order thinking to higher order behavior: exploring the relationship between early cognitive skills and social competence in black boys.

    PubMed

    Scott, Kristin M; Barbarin, Oscar A; Brown, Jeffrey M

    2013-01-01

    This study examines the relations of higher order (i.e., abstract) thinking (HOT) skills to specific domains of social competence in Black boys (n = 108) attending publicly sponsored prekindergarten (pre-K) programs. Data for the study were collected as part of the National Center for Early Development and Learning (NCEDL) Multi-State Study, a national, longitudinal study examining the quality and outcomes in a representative sample of publicly sponsored pre-K programs in six states (N = 240). Pre-K and kindergarten teachers rated randomly selected children on measures of abstract thinking, self-regulation, and social functioning at the beginning and end of each school year. Applying structural equation modeling, compared with earlier time points, HOT measured in the fall of kindergarten significantly predicted each of the domains of social competence in the spring of kindergarten, with the exception of peer social skills, while controlling for general cognitive ability. Results suggest that early intervention to improve HOT may be an effective and more focused approach to address concerns about Black boys' early social competencies in specific domains and potentially reduce the risk of later social difficulties. PMID:23889011

  1. Two-photon or higher-order absorbing optical materials and methods of use

    NASA Technical Reports Server (NTRS)

    Marder, Seth (Inventor); Perry, Joseph (Inventor)

    2012-01-01

    Compositions capable of simultaneous two-photon absorption and higher order absorptivities are provided. Compounds having a donor-pi-donor or acceptor-pi-acceptor structure are of particular interest, where the donor is an electron donating group, acceptor is an electron accepting group, and pi is a pi bridge linking the donor and/or acceptor groups. The pi bridge may additionally be substituted with electron donating or withdrawing groups to alter the absorptive wavelength of the structure. Also disclosed are methods of generating an excited state of such compounds through optical stimulation with light using simultaneous absorption of photons of energies individually insufficient to achieve an excited state of the compound, but capable of doing so upon simultaneous absorption of two or more such photons. Applications employing such methods are also provided, including controlled polymerization achieved through focusing of the light source(s) used.

  2. Lagrangian-Hamiltonian unified formalism for autonomous higher order dynamical systems

    NASA Astrophysics Data System (ADS)

    Prieto-Martínez, Pedro Daniel; Román-Roy, Narciso

    2011-09-01

    The Lagrangian-Hamiltonian unified formalism of Skinner and Rusk was originally stated for autonomous dynamical systems in classical mechanics. It has been generalized for non-autonomous first-order mechanical systems, as well as for first-order and higher order field theories. However, a complete generalization to higher order mechanical systems is yet to be described. In this work, after reviewing the natural geometrical setting and the Lagrangian and Hamiltonian formalisms for higher order autonomous mechanical systems, we develop a complete generalization of the Lagrangian-Hamiltonian unified formalism for these kinds of systems, and we use it to analyze some physical models from this new point of view.

  3. Higher-order elasticity of cubic metals in the embedded-atom method

    NASA Astrophysics Data System (ADS)

    Chantasiriwan, Somchart; Milstein, Frederick

    1996-06-01

    The higher-order elasticity of cubic metals in the framework of the embedded-atom method (EAM) is investigated. Proper groupings of the second- and third-order elastic moduli are shown to yield expressions that depend solely on either the electron density function or the pair potential and which therefore facilitate the construction of EAM models. This formulation also makes evident some important restrictions on the EAM functions and lattice summations. In order for the EAM to model the anharmonic properties accurately, (a) at least the third-nearest-neighbor interactions must be included in the expressions for the cohesive energies of both the body-centered-cubic and face-centered-cubic metals and (b) an electron density function of an inverse power form, as has been employed previously, generally is not valid. Specific EAM models are constructed for a diverse selection of metals (i.e., aluminum, copper, sodium, and molybdenum). These models identically reproduce the respective second- and third-order elastic moduli, as well as the binding energy, atomic volume, unrelaxed vacancy formation energy, and Rose's universal equation of state. They also provide reasonable phonon frequency spectra and structural energy differences

  4. Higher-order weakly nonlinear theory for internal waves in three-layer fluid

    NASA Astrophysics Data System (ADS)

    Kurkina, O. E.; Kurkin, A. A.; Rouvinskaya, E. A.

    2012-04-01

    Three-layer stratifications are proved to be a proper approximation of sea water density profile in some basins in the World Ocean with specific hydrological conditions. Some shallow basins such as the Baltic Sea and some river estuaries have more or less continuous three-layer vertical structure caused by the interplay of fresh water discharge to the surface and salt water intrusion in the bottom layers. In order to describe the basic features of the internal wave field in such environments it is necessary to introduce a three-layer model. Such models are considerably more complex than the most popular two-layer systems; however, they represent new dynamical effects and allow for much more analytical progress in their studies compared to the fully stratified situation. In the present study two modes of long internal gravity waves in a three-layer fluid are investigated in the framework of higher-order nonlinear evolutionary equations derived with the use of asymptotic procedure from the governing Euler equations for inviscid incompressible layered medium with "rigid lid" and horizontal impermeable bottom. The equations are written upto the fifth order of the perturbation theory for both interfaces for the waves of both modes: first (fast mode) and second (slow mode, so-called double-humped or varicose). For each equation the coefficients of nonlinearity, dispersion and nonlinear dispersion are expressed explicitly in terms of parameters of this fluid configuration. The behavior and signs of the coefficients are analyzed. The necessary order of the equations is discussed and determined for each case. A few nonlinear asymptotic transformations are proposed to reduce higher-order equations to simpler lower-order or well-known integrable equations (Korteweg - de Vries, Gardner equations). Special attention is paid to the situations when the nonlinear terms of lower orders of perturbation theory can vanish. For such situations particular rescaling is performed in order

  5. Lagrange-type modeling of continuous dielectric permittivity variation in double-higher-order volume integral equation method

    NASA Astrophysics Data System (ADS)

    Chobanyan, E.; Ilić, M. M.; Notaroš, B. M.

    2015-05-01

    A novel double-higher-order entire-domain volume integral equation (VIE) technique for efficient analysis of electromagnetic structures with continuously inhomogeneous dielectric materials is presented. The technique takes advantage of large curved hexahedral discretization elements—enabled by double-higher-order modeling (higher-order modeling of both the geometry and the current)—in applications involving highly inhomogeneous dielectric bodies. Lagrange-type modeling of an arbitrary continuous variation of the equivalent complex permittivity of the dielectric throughout each VIE geometrical element is implemented, in place of piecewise homogeneous approximate models of the inhomogeneous structures. The technique combines the features of the previous double-higher-order piecewise homogeneous VIE method and continuously inhomogeneous finite element method (FEM). This appears to be the first implementation and demonstration of a VIE method with double-higher-order discretization elements and conformal modeling of inhomogeneous dielectric materials embedded within elements that are also higher (arbitrary) order (with arbitrary material-representation orders within each curved and large VIE element). The new technique is validated and evaluated by comparisons with a continuously inhomogeneous double-higher-order FEM technique, a piecewise homogeneous version of the double-higher-order VIE technique, and a commercial piecewise homogeneous FEM code. The examples include two real-world applications involving continuously inhomogeneous permittivity profiles: scattering from an egg-shaped melting hailstone and near-field analysis of a Luneburg lens, illuminated by a corrugated horn antenna. The results show that the new technique is more efficient and ensures considerable reductions in the number of unknowns and computational time when compared to the three alternative approaches.

  6. Questions for Assessing Higher-Order Cognitive Skills: It's Not Just Bloom's

    ERIC Educational Resources Information Center

    Lemons, Paula P.; Lemons, J. Derrick

    2013-01-01

    We present an exploratory study of biologists' ideas about higher-order cognition questions. We documented the conversations of biologists who were writing and reviewing a set of higher-order cognition questions. Using a qualitative approach, we identified the themes of these conversations. Biologists in our study used Bloom's Taxonomy to…

  7. Assessing Higher-Order Cognitive Constructs by Using an Information-Processing Framework

    ERIC Educational Resources Information Center

    Dickison, Philip; Luo, Xiao; Kim, Doyoung; Woo, Ada; Muntean, William; Bergstrom, Betty

    2016-01-01

    Designing a theory-based assessment with sound psychometric qualities to measure a higher-order cognitive construct is a highly desired yet challenging task for many practitioners. This paper proposes a framework for designing a theory-based assessment to measure a higher-order cognitive construct. This framework results in a modularized yet…

  8. An Analysis of Higher-Order Thinking on Algebra I End-of-Course Tests

    ERIC Educational Resources Information Center

    Thompson, Tony

    2011-01-01

    This research provides insight into one US state's effort to incorporate higher-order thinking on its Algebra I End-of-Course tests. To facilitate the inclusion of higher-order thinking, the state used "Dimensions of Thinking" (Marzano et al., 1988) and "Bloom's Taxonomy" (Bloom et al., 1956). An analysis of Algebra I test items found that the…

  9. Assessment of Higher Order Thinking Skills. Current Perspectives on Cognition, Learning and Instruction

    ERIC Educational Resources Information Center

    Schraw, Gregory, Ed.; Robinson, Daniel H., Ed.

    2011-01-01

    This volume examines the assessment of higher order thinking skills from the perspectives of applied cognitive psychology and measurement theory. The volume considers a variety of higher order thinking skills, including problem solving, critical thinking, argumentation, decision making, creativity, metacognition, and self-regulation. Fourteen…

  10. Family Consumer Sciences Teachers' Use of Technology to Teach Higher Order Thinking Skills

    ERIC Educational Resources Information Center

    Hirose, Beth Erica

    2009-01-01

    Family and consumer sciences (FACS) high school teachers were surveyed on their use of technology to teach higher order thinking skills (HOTS). This study determined if teachers had enough support and training to use technology. Lesson plans were accumulated that required both technology and higher order thinking skills. These lessons were then…

  11. A Lagrangian description of the higher-order Painlevé equations

    NASA Astrophysics Data System (ADS)

    Ghose Choudhury, A.; Guha, Partha; Kudryashov, N. A.

    2012-05-01

    We derive the Lagrangians of the higher-order Painlevé equations using Jacobi's last multiplier technique. Some of these higher-order differential equations display certain remarkable properties like passing the Painlevé test and satisfy the conditions stated by Juráš, thus allowing for a Lagrangian description.

  12. Teaching Higher Order Thinking in the Introductory MIS Course: A Model-Directed Approach

    ERIC Educational Resources Information Center

    Wang, Shouhong; Wang, Hai

    2011-01-01

    One vision of education evolution is to change the modes of thinking of students. Critical thinking, design thinking, and system thinking are higher order thinking paradigms that are specifically pertinent to business education. A model-directed approach to teaching and learning higher order thinking is proposed. An example of application of the…

  13. Authentic Instruction for 21st Century Learning: Higher Order Thinking in an Inclusive School

    ERIC Educational Resources Information Center

    Preus, Betty

    2012-01-01

    The author studied a public junior high school identified as successfully implementing authentic instruction. Such instruction emphasizes higher order thinking, deep knowledge, substantive conversation, and value beyond school. To determine in what ways higher order thinking was fostered both for students with and without disabilities, the author…

  14. Assessing Teachers' Beliefs Regarding Issues Pertaining to Instruction of Higher Order Thinking.

    ERIC Educational Resources Information Center

    Shwartzer, Noa; Zohar, Anat

    The purposes of this study are to describe the development and validation of a research instrument for assessing teachers' beliefs regarding issues pertaining to the instruction of higher order thinking, and to explore the beliefs of Israeli science teachers regarding issues pertaining to instruction of higher order thinking. This paper describes…

  15. From "Hello" to Higher-Order Thinking: The Effect of Coaching and Feedback on Online Chats

    ERIC Educational Resources Information Center

    Stein, David S.; Wanstreet, Constance E.; Slagle, Paula; Trinko, Lynn A.; Lutz, Michelle

    2013-01-01

    This exploratory study examined the effect of a coaching and feedback intervention in teaching presence and social presence on higher-order thinking in an online community of inquiry. Coaching occurred before each chat, and feedback was provided immediately afterwards. The findings suggest that over time, the frequency of higher-order thinking…

  16. Ability, Breadth, and Parsimony in Computational Models of Higher-Order Cognition

    ERIC Educational Resources Information Center

    Cassimatis, Nicholas L.; Bello, Paul; Langley, Pat

    2008-01-01

    Computational models will play an important role in our understanding of human higher-order cognition. How can a model's contribution to this goal be evaluated? This article argues that three important aspects of a model of higher-order cognition to evaluate are (a) its ability to reason, solve problems, converse, and learn as well as people do;…

  17. Parenting Quality: Confirmation of a Higher-Order Latent Construct with Mothers of Head Start Children

    ERIC Educational Resources Information Center

    Hubbs-Tait, Laura; Page, Melanie C.; Huey, Erron L.; Starost, Huei-Juang; Culp, Anne McDonald; Culp, Rex E.; Harper, M. Elizabeth

    2006-01-01

    We proposed a higher order latent construct of parenting young children, parenting quality. This higher-order latent construct comprises five component constructs: demographic protection, psychological distress, psychosocial maturity, moral and cognitive reflectivity, and parenting attitudes and beliefs. We evaluated this model with data provided…

  18. Effect of higher-order multipole moments on the Stark line shape

    NASA Astrophysics Data System (ADS)

    Gomez, T. A.; Nagayama, T.; Kilcrease, D. P.; Montgomery, M. H.; Winget, D. E.

    2016-08-01

    Spectral line shapes are sensitive to plasma conditions and are often used to diagnose electron density of laboratory plasmas as well as astrophysical plasmas. Stark line-shape models take into account the perturbation of the radiator's energy structure due to the Coulomb interaction with the surrounding charged particles. Solving this Coulomb interaction is challenging and is commonly approximated via a multipole expansion. However, most models include only up to the second term of the expansion (the dipole term). While there have been studies on the higher-order terms due to one of the species (i.e., either ions or electrons), there is no model that includes the terms beyond dipole from both species. Here, we investigate the importance of the higher-order multipole terms from both species on the Hβ line shape. First, we find that it is important to include higher-order terms consistently from both ions and electrons to reproduce measured line-shape asymmetry. Next, we find that the line shape calculated with the dipole-only approximation becomes inaccurate as density increases. It is necessary to include up to the third (quadrupole) term to compute the line shape accurately within 2%. Since most existing models include only up to the dipole terms, the densities inferred with such models are in question. We find that the model without the quadrupole term slightly underestimates the density, and the discrepancy becomes as large as 12% at high densities. While the case of study is limited to Hβ, we expect similar impact on other lines.

  19. Effect of higher-order multipole moments on the Stark line shape

    NASA Astrophysics Data System (ADS)

    Gomez, T. A.; Nagayama, T.; Kilcrease, D. P.; Montgomery, M. H.; Winget, D. E.

    2016-08-01

    Spectral line shapes are sensitive to plasma conditions and are often used to diagnose electron density of laboratory plasmas as well as astrophysical plasmas. Stark line-shape models take into account the perturbation of the radiator's energy structure due to the Coulomb interaction with the surrounding charged particles. Solving this Coulomb interaction is challenging and is commonly approximated via a multipole expansion. However, most models include only up to the second term of the expansion (the dipole term). While there have been studies on the higher-order terms due to one of the species (i.e., either ions or electrons), there is no model that includes the terms beyond dipole from both species. Here, we investigate the importance of the higher-order multipole terms from both species on the H β line shape. First, we find that it is important to include higher-order terms consistently from both ions and electrons to reproduce measured line-shape asymmetry. Next, we find that the line shape calculated with the dipole-only approximation becomes inaccurate as density increases. It is necessary to include up to the third (quadrupole) term to compute the line shape accurately within 2%. Since most existing models include only up to the dipole terms, the densities inferred with such models are in question. We find that the model without the quadrupole term slightly underestimates the density, and the discrepancy becomes as large as 12% at high densities. While the case of study is limited to H β , we expect similar impact on other lines.

  20. Construction of special eye models for investigation of chromatic and higher-order aberrations of eyes.

    PubMed

    Zhai, Yi; Wang, Yan; Wang, Zhaoqi; Liu, Yongji; Zhang, Lin; He, Yuanqing; Chang, Shengjiang

    2014-01-01

    An achromatic element eliminating only longitudinal chromatic aberration (LCA) while maintaining transverse chromatic aberration (TCA) is established for the eye model, which involves the angle formed by the visual and optical axis. To investigate the impacts of higher-order aberrations on vision, the actual data of higher-order aberrations of human eyes with three typical levels are introduced into the eye model along visual axis. Moreover, three kinds of individual eye models are established to investigate the impacts of higher-order aberrations, chromatic aberration (LCA+TCA), LCA and TCA on vision under the photopic condition, respectively. Results show that for most human eyes, the impact of chromatic aberration on vision is much stronger than that of higher-order aberrations, and the impact of LCA in chromatic aberration dominates. The impact of TCA is approximately equal to that of normal level higher-order aberrations and it can be ignored when LCA exists. PMID:25227016

  1. Testing higher-order Lagrangian perturbation theory against numerical simulations. 2: Hierarchical models

    NASA Technical Reports Server (NTRS)

    Melott, A. L.; Buchert, T.; Weib, A. G.

    1995-01-01

    We present results showing an improvement of the accuracy of perturbation theory as applied to cosmological structure formation for a useful range of scales. The Lagrangian theory of gravitational instability of Friedmann-Lemaitre cosmogonies is compared with numerical simulations. We study the dynamics of hierarchical models as a second step. In the first step we analyzed the performance of the Lagrangian schemes for pancake models, the difference being that in the latter models the initial power spectrum is truncated. This work probed the quasi-linear and weakly non-linear regimes. We here explore whether the results found for pancake models carry over to hierarchical models which are evolved deeply into the non-linear regime. We smooth the initial data by using a variety of filter types and filter scales in order to determine the optimal performance of the analytical models, as has been done for the 'Zel'dovich-approximation' - hereafter TZA - in previous work. We find that for spectra with negative power-index the second-order scheme performs considerably better than TZA in terms of statistics which probe the dynamics, and slightly better in terms of low-order statistics like the power-spectrum. However, in contrast to the results found for pancake models, where the higher-order schemes get worse than TZA at late non-linear stages and on small scales, we here find that the second-order model is as robust as TZA, retaining the improvement at later stages and on smaller scales. In view of these results we expect that the second-order truncated Lagrangian model is especially useful for the modelling of standard dark matter models such as Hot-, Cold-, and Mixed-Dark-Matter.

  2. Higher-order Schrödinger and Hartree–Fock equations

    SciTech Connect

    Carles, Rémi; Lucha, Wolfgang; Moulay, Emmanuel

    2015-12-15

    The domain of validity of the higher-order Schrödinger equations is analyzed for harmonic-oscillator and Coulomb potentials as typical examples. Then, the Cauchy theory for higher-order Hartree–Fock equations with bounded and Coulomb potentials is developed. Finally, the existence of associated ground states for the odd-order equations is proved. This renders these quantum equations relevant for physics.

  3. Detection of sea mines in sonar imagery using higher-order spectral features

    NASA Astrophysics Data System (ADS)

    Chandran, Vinod; Elgar, Steve L.

    1999-08-01

    A new approach to detection of sea-mines in sonar imagery that improves the detection density ACF method is presented. The steps are: 1) background normalization, 2) spatially adaptive Wiener filtering, 3) convolution with a 2D FIR filter matched to the target signature, 4) adaptive thresholding to reduce noise, 5) extraction of higher-order spectral features to capture the spatial correlations, 6) extraction of size, strength, and density features, 7) optimal feature selection, and 8) classification. An adaptive Wiener filter is applied to remove noise without destroying the structural information in the mine shapes. The FIR filter is designed to suppress noise and clutter, while enhancing the target signature. A double peak pattern is revealed as the filter passes over highlight and shadow regions. The location, size, and orientation of this pattern can vary. Higher-order spectral features capture the spatial correlations in this pattern and provide invariance to translation and scaling. The approach has been tested on the CSS Sonar 3 database of 60 images with about 84 percent classification accuracy and 11 percent probability of false alarm.

  4. Parallel Higher-order Finite Element Method for Accurate Field Computations in Wakefield and PIC Simulations

    SciTech Connect

    Candel, A.; Kabel, A.; Lee, L.; Li, Z.; Limborg, C.; Ng, C.; Prudencio, E.; Schussman, G.; Uplenchwar, R.; Ko, K.; /SLAC

    2009-06-19

    Over the past years, SLAC's Advanced Computations Department (ACD), under SciDAC sponsorship, has developed a suite of 3D (2D) parallel higher-order finite element (FE) codes, T3P (T2P) and Pic3P (Pic2P), aimed at accurate, large-scale simulation of wakefields and particle-field interactions in radio-frequency (RF) cavities of complex shape. The codes are built on the FE infrastructure that supports SLAC's frequency domain codes, Omega3P and S3P, to utilize conformal tetrahedral (triangular)meshes, higher-order basis functions and quadratic geometry approximation. For time integration, they adopt an unconditionally stable implicit scheme. Pic3P (Pic2P) extends T3P (T2P) to treat charged-particle dynamics self-consistently using the PIC (particle-in-cell) approach, the first such implementation on a conformal, unstructured grid using Whitney basis functions. Examples from applications to the International Linear Collider (ILC), Positron Electron Project-II (PEP-II), Linac Coherent Light Source (LCLS) and other accelerators will be presented to compare the accuracy and computational efficiency of these codes versus their counterparts using structured grids.

  5. Geometric Integrators for Higher-Order Variational Systems and Their Application to Optimal Control

    NASA Astrophysics Data System (ADS)

    Colombo, Leonardo; Ferraro, Sebastián; Martín de Diego, David

    2016-07-01

    Numerical methods that preserve geometric invariants of the system, such as energy, momentum or the symplectic form, are called geometric integrators. In this paper we present a method to construct symplectic-momentum integrators for higher-order Lagrangian systems. Given a regular higher-order Lagrangian L:T^{(k)}Q→ R with k≥ 1 , the resulting discrete equations define a generally implicit numerical integrator algorithm on T^{(k-1)}Q× T^{(k-1)}Q that approximates the flow of the higher-order Euler-Lagrange equations for L. The algorithm equations are called higher-order discrete Euler-Lagrange equations and constitute a variational integrator for higher-order mechanical systems. The general idea for those variational integrators is to directly discretize Hamilton's principle rather than the equations of motion in a way that preserves the invariants of the original system, notably the symplectic form and, via a discrete version of Noether's theorem, the momentum map. We construct an exact discrete Lagrangian L_d^e using the locally unique solution of the higher-order Euler-Lagrange equations for L with boundary conditions. By taking the discrete Lagrangian as an approximation of L_d^e , we obtain variational integrators for higher-order mechanical systems. We apply our techniques to optimal control problems since, given a cost function, the optimal control problem is understood as a second-order variational problem.

  6. Exploratory Movement Generates Higher-Order Information That Is Sufficient for Accurate Perception of Scaled Egocentric Distance

    PubMed Central

    Mantel, Bruno; Stoffregen, Thomas A.; Campbell, Alain; Bardy, Benoît G.

    2015-01-01

    Body movement influences the structure of multiple forms of ambient energy, including optics and gravito-inertial force. Some researchers have argued that egocentric distance is derived from inferential integration of visual and non-visual stimulation. We suggest that accurate information about egocentric distance exists in perceptual stimulation as higher-order patterns that extend across optics and inertia. We formalize a pattern that specifies the egocentric distance of a stationary object across higher-order relations between optics and inertia. This higher-order parameter is created by self-generated movement of the perceiver in inertial space relative to the illuminated environment. For this reason, we placed minimal restrictions on the exploratory movements of our participants. We asked whether humans can detect and use the information available in this higher-order pattern. Participants judged whether a virtual object was within reach. We manipulated relations between body movement and the ambient structure of optics and inertia. Judgments were precise and accurate when the higher-order optical-inertial parameter was available. When only optic flow was available, judgments were poor. Our results reveal that participants perceived egocentric distance from the higher-order, optical-inertial consequences of their own exploratory activity. Analysis of participants’ movement trajectories revealed that self-selected movements were complex, and tended to optimize availability of the optical-inertial pattern that specifies egocentric distance. We argue that accurate information about egocentric distance exists in higher-order patterns of ambient energy, that self-generated movement can generate these higher-order patterns, and that these patterns can be detected and used to support perception of egocentric distance that is precise and accurate. PMID:25856410

  7. Electric field controlled higher-order diffraction images of paraelectric potassium lithium tantalate niobate

    NASA Astrophysics Data System (ADS)

    Gong, Dewei; Chen, Changqing; Tian, Hao; Zhou, Zhongxiang

    2012-09-01

    We report some electric field controlled photorefractive higher-order diffraction phenomena of a paraelectric phase potassium lithium tantalate niobate crystal doped with iron. In experiments, a p-polarized semiconductor laser (532 nm) was used to record grating at a small incident angle. Higher-order diffraction images were observed when the signal beam was focused behind and in front of the crystal. Then the higher-order diffraction images were reconstructed by a p-polarized He-Ne laser (632.8 nm) in the direction perpendicular to the surface. The higher-order diffraction images could be controlled by the external electric field. A theory about the higher-order diffraction images of the K and 2K grating is developed. The results show that the even order diffraction images of the K grating and the odd order diffraction of the 2K grating overlap each other. The odd order diffraction images of the K grating are diffracted in unattached direction. The electric field controlled higher-order diffraction image provides a useful method for optical information processing.

  8. Higher Order Characterization of Heuristics for Compass and Straight Edge Constructions in Geometry. Report No. 70.

    ERIC Educational Resources Information Center

    Scandura, Joseph M.; And Others

    A quasi-systematic strategy of devising rule sets for problem solving is applied to ruler and compass geometrical constructions. "Lower order" rules consisting of basic skills and "higher order" rules which govern the selection and combination of lower order rules are identified by an analysis of problem types; three types of construction problems…

  9. Novel Object Exploration as a Potential Assay for Higher Order Repetitive Behaviors in Mice.

    PubMed

    Steinbach, Jessica M; Garza, Elizabeth T; Ryan, Bryce C

    2016-01-01

    Restricted, repetitive behaviors (RRBs) are a core feature of autism spectrum disorder (ASD) and disrupt the lives of affected individuals. RRBs are commonly split into lower-order and higher-order components, with lower order RRBs consisting of motor stereotypies and higher order RRBs consisting of perseverative and sequencing behaviors. Higher order RRBs are challenging to model in mice. Current assays for RRBs in mice focus primarily on the lower order components, making basic biomedical research into potential treatments or interventions for higher-order RRBs difficult. Here we describe a new assay, novel object exploration. This assay uses a basic open-field arena with four novel objects placed around the perimeter. The test mouse is allowed to freely explore the arena and the order in which the mouse investigates the novel objects is recorded. From these data, patterned sequences of exploration can be identified, as can the most preferred object for each mouse. The representative data shared here and past results using the novel object exploration assay illustrate that inbred mouse strains do demonstrate different behavior in this assay and that strains with elevated lower order RRBs also show elevated patterned behavior. As such, the novel object exploration assay appears to possess good face validity for higher order RRBs in humans and may be a valuable assay for future studies investigating novel therapeutics for ASD. PMID:27583676

  10. On the stability and convergence of higher-order mixed finite element methods for second-order elliptic problems

    NASA Astrophysics Data System (ADS)

    Suri, Manil

    1990-01-01

    We investigate the use of higher-order mixed methods for second-order elliptic problems by establishing refined stability and convergence estimates which take into account both the mesh size h and polynomial degree p. Our estimates yield asymptotic convergence rates for the p- and h - p-versions of the finite element method. They also describe more accurately than previously proved estimates the increased rate of convergence expected when the h-version is used with higher-order polynomials. For our analysis, we choose the Raviart-Thomas and the Brezzi-Douglas-Marini elements and establish optimal rates of convergence in both h and p (up to arbitrary \\varepsilon > 0 ).

  11. Sensitivity analysis of complex coupled systems extended to second and higher order derivatives

    NASA Technical Reports Server (NTRS)

    Sobieszczanski-Sobieski, Jaroslaw

    1989-01-01

    In design of engineering systems, the what if questions often arise such as: what will be the change of the aircraft payload, if the wing aspect ratio is incremented by 10 percent. Answers to such questions are commonly sought by incrementing the pertinent variable, and reevaluating the major disciplinary analyses involved. These analyses are contributed by engineering disciplines that are, usually, coupled, as are the aerodynamics, structures, and performance in the context of the question above. The what if questions can be answered precisely by computation of the derivatives. A method for calculation of the first derivatives has been developed previously. An algorithm is presented for calculation of the second and higher order derivatives.

  12. Higher order QCD predictions for associated Higgs production with anomalous couplings to gauge bosons

    NASA Astrophysics Data System (ADS)

    Mimasu, Ken; Sanz, Verónica; Williams, Ciaran

    2016-08-01

    We present predictions for the associated production of a Higgs boson at NLO+PS accuracy, including the effect of anomalous interactions between the Higgs and gauge bosons. We present our results in different frameworks, one in which the interaction vertex between the Higgs boson and Standard Model W and Z bosons is parameterized in terms of general Lorentz structures, and one in which Electroweak symmetry breaking is manifestly linear and the resulting operators arise through a six-dimensional effective field theory framework. We present analytic calculations of the Standard Model and Beyond the Standard Model contributions, and discuss the phenomenological impact of the higher order pieces. Our results are implemented in the NLO Monte Carlo program MCFM, and interfaced to shower Monte Carlos through the Powheg box framework.

  13. Semantic Segmentation of Aerial Images in Urban Areas with Class-Specific Higher-Order Cliques

    NASA Astrophysics Data System (ADS)

    Montoya-Zegarra, J. A.; Wegner, J. D.; Ladický, L.; Schindler, K.

    2015-03-01

    In this paper we propose an approach to multi-class semantic segmentation of urban areas in high-resolution aerial images with classspecific object priors for buildings and roads. What makes model design challenging are highly heterogeneous object appearances and shapes that call for priors beyond standard smoothness or co-occurrence assumptions. The data term of our energy function consists of a pixel-wise classifier that learns local co-occurrence patterns in urban environments. To specifically model the structure of roads and buildings, we add high-level shape representations for both classes by sampling large sets of putative object candidates. Buildings are represented by sets of compact polygons, while roads are modeled as a collection of long, narrow segments. To obtain the final pixel-wise labeling, we use a CRF with higher-order potentials that balances the data term with the object candidates. We achieve overall labeling accuracies of > 80%.

  14. Conceptual design of a superconducting quadrupole with elliptical acceptance and tunable higher order multipoles.

    SciTech Connect

    Manikonda, S.; Nolen, J.; Berz, M.; Makino, K.; Physics; Michigan State Univ.

    2009-01-01

    For charged particle beams that are wider in the dispersive plane compared to the transverse plane it is cost efficient to utilize magnets that accept beams with elliptic cross section. In this paper we presents the conceptual design of a quadrupole magnet with elliptic cross section and with tunable higher order multipoles. The design consists of 18 superconducting race-track coils placed on two hollow concentric rhombic prism support structures. To compute the magnetic field for the proposed design a new method of calculating 2D and 3D fields for the air core magnets based on differential algebra (DA) techniques is developed. We will present the new method and discuss its implementation of new numerical tools based on this method in the code COSY Infinity.

  15. Axial Higher Order Modes Cluster A-Homc Guided Wave for Pipe Inspection

    NASA Astrophysics Data System (ADS)

    Chandrasekaran, Jayaraman; Krishnamurthy, C. V.; Balasubramaniam, Krishnan

    2010-02-01

    This paper reports the potential of Higher Order Modes Cluster Guided Waves (HOMC-GW) which are highly non-dispersive for axial testing in pipe over a couple of meters. The HOMC-GW is a recently explored phenomena which is found to occur at very high frequency-thickness product i.e. 15 MHz.mm to 35 MHz.mm. 2D ABAQUS finite element simulations were used to decide the optimal wedge angle which facilitates the generation of the HOMC-GW. Experiments were carried out on a 6 inch diameter mild steel pipe with machined pin hole type defects of various diameter and depth. A commercial 2.25 MHz, 1 inch diameter transducer mounted on a machined acrylic wedge was used. The potential of axially propagating HOMC-GW on pipe like structures is being brought into light.

  16. Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material.

    PubMed

    Lawo, Steffen; Hasegan, Monica; Gupta, Gagan D; Pelletier, Laurence

    2012-11-01

    The centrosome is the main microtubule organization centre of animal cells. It is composed of a centriole pair surrounded by pericentriolar material (PCM). Traditionally described as amorphous, the architecture of the PCM is not known, although its intricate mode of assembly alludes to the presence of a functional, hierarchical structure. Here we used subdiffraction imaging to reveal organizational features of the PCM. Interphase PCM components adopt a concentric toroidal distribution of discrete diameter around centrioles. Positional mapping of multiple non-overlapping epitopes revealed that pericentrin (PCNT) is an elongated molecule extending away from the centriole. We find that PCM components occupy separable spatial domains within mitotic PCM that are maintained in the absence of microtubule nucleation complexes and further implicate PCNT and CDK5RAP2 in the organization and assembly of PCM. Globally, this work highlights the role of higher-order PCM organization in the regulation of centrosome assembly and function. PMID:23086237

  17. Higher-order mode analysis at the BNL Energy Recovery Linac

    SciTech Connect

    Johnson, E.C.; Ben-Zvi, I.; Hahn, H.; Hammons, L.; Xu, W.

    2011-08-03

    Understanding the prevalence and structure of higher-order modes (HOMs) in accelerator cavities is critical because their excitation can result in problematic single bunch and multi-bunch effects. Particularly hazardous are dipole modes, which are more easily excited due to their linear field nature near the beam center. During a recent superconducting test on the energy recovery linac (ERL) cavity at Brookhaven National Laboratory (BNL), 8 of the highest-Q HOMs were measured for the first time. In conjunction with analysis of CST Microwave Studio simulation results for the ERL model, one of these modes was further studied in the copper prototype ERL cavity. A method of identifying HOMs utilizing existing holes drilled in copper cavity cells was developed and used to conclude that the observed high-Q mode was a quadrupole.

  18. A Content Analysis of General Chemistry Laboratory Manuals for Evidence of Higher-Order Cognitive Tasks

    NASA Astrophysics Data System (ADS)

    Domin, Daniel S.

    1999-01-01

    The science laboratory instructional environment is ideal for fostering the development of problem-solving, manipulative, and higher-order thinking skills: the skills needed by today's learner to compete in an ever increasing technology-based society. This paper reports the results of a content analysis of ten general chemistry laboratory manuals. Three experiments from each manual were examined for evidence of higher-order cognitive activities. Analysis was based upon the six major cognitive categories of Bloom's Taxonomy of Educational Objectives: knowledge, comprehension, application, analysis, synthesis, and evaluation. The results of this study show that the overwhelming majority of general chemistry laboratory manuals provide tasks that require the use of only the lower-order cognitive skills: knowledge, comprehension, and application. Two of the laboratory manuals were disparate in having activities that utilized higher-order cognition. I describe the instructional strategies used within these manuals to foster higher-order cognitive development.

  19. Higher-order mass defect analysis for mass spectra of complex organic mixtures.

    PubMed

    Roach, Patrick J; Laskin, Julia; Laskin, Alexander

    2011-06-15

    Higher-order mass defect analysis is introduced as a unique formula assignment and visualization method for the analysis of complex mass spectra. This approach is an extension of the concepts of Kendrick mass transformation widely used for identification of homologous compounds differing only by a number of base units (e.g., CH(2), H(2), O, CH(2)O, etc.) in complex mixtures. We present an iterative renormalization routine for defining higher-order homologous series and multidimensional clustering of mass spectral features. This approach greatly simplifies visualization of complex mass spectra and increases the number of chemical formulas that can be confidently assigned for given mass accuracy. The potential for using higher-order mass defects for data reduction and visualization is shown. Higher-order mass defect analysis is described and demonstrated through third-order analysis of a deisotoped high-resolution mass spectrum of crude oil containing nearly 13,000 peaks. PMID:21526851

  20. Wavelet and Higher order statistics as a tool for revealing Electromagnetic precursors of Earthquakes

    NASA Astrophysics Data System (ADS)

    Sondhiya, Deepak Kumar; Gwal, Ashok Kumar; Kumar, Sushil

    2016-07-01

    In recent years a number of scientists have reported correlations between observations of electromagnetic radiation and earthquakes. These observation of seismo-electromagnetic waves have been made both on the ground in the earthquake regions and by spacecraft over earthquake regions. In this work an attempt to develop a complex approach to the problem of searching for electromagnetic earthquake precursor signatures is made on the basis of DEMETER satellite observation.The main focus is concerned with the analysis of electric field data in Very Low Frequency (VLF) range using wavelet transform and higher order statistics. We observed electromagnetic turbulence in VLF range resulting from three earthquakes occurred at Keplulauan, Talud, Indonesia form 2009-2011.It is probably due to generation of electric field in a forthcoming earthquake's epicentral zone and penetrating in to the ionosphere. Large value of kurtosis shows the higher level of intermittence in the VLF signal before earthquake. It is possible to conjecture that the sources of this intermittence are the Coherent Structure (CS). For the better understanding of this behavior skewness parameter are used. The high energy at the large scales of the VLF turbulence due the earthquake preparation process contributes to creation of CS in the VLF signal. The results discussed were obtained during a very quiet time and therefore no ionospheric and magnetospheric sources of perturbation were expected. The statistical behavior of the signal (intermittent) and the shape of the spectra suggest that turbulence observed during this event is of the Kolmogorov type. Keywords: Turbulence, Higher order statistics and wave-wave interaction

  1. Approach to the glass transition studied by higher order correlation functions

    NASA Astrophysics Data System (ADS)

    Lacevic, N.; Glotzer, S. C.

    2003-08-01

    We present a theoretical framework based on a higher order density correlation function, analogous to that used to investigate spin glasses, to describe dynamical heterogeneities in simulated glass-forming liquids. These higher order correlation functions are a four-point, time-dependent density correlation function g4(r,t) and a corresponding 'structure factor' S4(q,t) which measure the spatial correlations between the local liquid density at two points in space, each at two different times. g4(r,t) and S4(q,t) were extensively studied via molecular dynamics simulations of a binary Lennard-Jones mixture approaching the mode coupling temperature from above in Franz et al (1999 Phil. Mag. B 79 1827), Donati et al (2002 J. Non-Cryst. Solids 307 215), Glotzer et al (2000 J. Chem. Phys. 112 509), Lacevic et al (2002 Phys. Rev. E 66 030101), Lacevic et al (2003 J. Chem. Phys. submitted) and Lacevic (2003 Dissertation The Johns Hopkins University). Here, we examine the contribution to g4(r,t), S4(q,t) and the corresponding dynamical correlation length, as well as the corresponding order parameter Q(t) and generalized susceptibility chi4(t), from localized particles. We show that the dynamical correlation length xi4SS(t) of localized particles has a maximum as a function of time t, and the value of the maximum of xi4SS(t) increases steadily in the temperature range approaching the mode coupling temperature from above.

  2. Experimental study of diode pumped rubidium amplifier for single higher-order Laguerre-Gaussian modes.

    PubMed

    Luo, Ruiyao; Li, Lei; Cui, Wenda; Yang, Zining; Wang, Hongyan; Xu, Xiaojun

    2016-06-13

    In this paper, we have set up a diode laser pumped rubidium amplifier for higher-order Laguerre-Gauss (LG) modes. We experimentally realized amplification of higher-order LG modes including helical and sinusoidal LG03, LG13, LG23, and LG33 modes with their high purity held. This novel scheme of generating high-purity higher-order LG beams at high laser power is preferred to the second-generation gravitational wave interferometers. To the best of our knowledge, it is the first time this scheme is formulated. PMID:27410352

  3. Modulational instability of a modified Gross-Pitaevskii equation with higher-order nonlinearity.

    PubMed

    Qi, Xiu-Ying; Xue, Ju-Kui

    2012-07-01

    We consider the modulational instability (MI) of Bose-Einstein condensate (BEC) described by a modified Gross-Pitaevskii (GP) equation with higher-order nonlinearity both analytically and numerically. A new explicit time-dependent criterion for exciting the MI is obtained. It is shown that the higher-order term can either suppress or enhance the MI, which is interesting for control of the system instability. Importantly, we predict that with the help of the higher-order nonlinearity, the MI can also take place in a BEC with repulsively contact interactions. The analytical results are confirmed by direct numerical simulations. PMID:23005569

  4. Higher-Order Spectral Analysis of a Nonlinear Pitch and Plunge Apparatus

    NASA Technical Reports Server (NTRS)

    Silva, Walter A.; Strganac, Thomas W.; Hajj, Muhammad R.

    2005-01-01

    Simulated aeroelastic responses of a nonlinear pitch and plunge apparatus are analyzed using various statistical signal processing techniques including higher-order spectral methods. A MATLAB version of the Nonlinear Aeroelastic Testbed Apparatus (NATA) at the Texas A&M University is used to generate various aeroelastic response data including limit cycle oscillations (LCO). Traditional and higher-order spectral (HOS) methods are applied to the simulated aeroelastic responses. Higher-order spectral methods are used to identify critical signatures that indicate the transition from linear to nonlinear (LCO) aeroelastic behavior.

  5. Nonlocal Symmetry Reductions, CTE Method and Exact Solutions for Higher-Order KdV Equation

    NASA Astrophysics Data System (ADS)

    Ren, Bo; Liu, Xi-Zhong; Liu, Ping

    2015-02-01

    The nonlocal symmetries for the higher-order KdV equation are obtained with the truncated Painlevé method. The nonlocal symmetries can be localized to the Lie point symmetries by introducing suitable prolonged systems. The finite symmetry transformations and similarity reductions for the prolonged systems are computed. Moreover, the consistent tanh expansion (CTE) method is applied to the higher-order KdV equation. These methods lead to some novel exact solutions of the higher-order KdV system.

  6. Pulse transmission receiver with higher-order time derivative pulse correlator

    DOEpatents

    Dress, Jr., William B.; Smith, Stephen F.

    2003-09-16

    Systems and methods for pulse-transmission low-power communication modes are disclosed. A pulse transmission receiver includes: a higher-order time derivative pulse correlator; a demodulation decoder coupled to the higher-order time derivative pulse correlator; a clock coupled to the demodulation decoder; and a pseudorandom polynomial generator coupled to both the higher-order time derivative pulse correlator and the clock. The systems and methods significantly reduce lower-frequency emissions from pulse transmission spread-spectrum communication modes, which reduces potentially harmful interference to existing radio frequency services and users and also simultaneously permit transmission of multiple data bits by utilizing specific pulse shapes.

  7. The Use of Higher-Order Difference Methods in Beam Vibration Analysis

    NASA Technical Reports Server (NTRS)

    Greenwood, Donald T.

    1961-01-01

    Simple and higher-order difference methods for the solution for the natural frequencies of vibration of a uniform beam are compared. The same basic higher-order method is used throughout for the interior cells, but three different methods of boundary-condition representation are given. Tables and graphs of the error in mode frequencies, as compared with a continuous beam, are given for the various methods as a function of the number of cells. It is concluded that higher-order methods improve accuracy for a given number of cells, with essentially no change in the quantity of computing equipment required.

  8. Higher Order Pattern Structure Influences Auditory Representational Momentum

    ERIC Educational Resources Information Center

    Johnston, Heather Moynihan; Jones, Mari Riess

    2006-01-01

    Representational momentum refers to the phenomenon that observers tend to incorrectly remember an event undergoing real or implied motion as shifted beyond its actual final position. This has been demonstrated in both visual and auditory domains. In 5 pitch discrimination experiments, listeners heard tone sequences that implied either linear,…

  9. Shock waves with higher order effects in an electron depleted dusty Plasma

    NASA Astrophysics Data System (ADS)

    Ghai, Yashika; Singh Saini, Nareshpal; Singh, Manpreet

    2016-07-01

    Shock waves are characterized as a sudden change in properties of the medium that propagate faster than the speed of sound. A plasma system in which dissipation is dominant over dispersion of the medium, the balance between dissipation and nonlinearity leads to the formation of shock structures. A number of observations and in-situ measurements have confirmed the presence of excess superthermal populations in astrophysical and space plasmas. In fact, two temperature superthermal ion populations have been observed by Geotail spacecraft in earth's magnetotail. Moreover, charging of dust by accumulation of electrons in plasma leads to electron depleted plasma. In present investigation, shocks in an electron depleted dusty plasma with two temperature superthermal ions have been studied by using Burger's equation. Further, to incorporate higher order nonlinear effects, we have derived modified Burger's equation and studied its shock solution. The effects of various physical parameters such as superthermality of ions, kinematic viscosity and dust concentration have been observed on properties of shock structures. The results of present investigation may be useful in understanding the nonlinear structures formed in earth's atmosphere where dust and two temperature superthermal ions are observed.

  10. Soliton solutions of the KdV equation with higher-order corrections

    NASA Astrophysics Data System (ADS)

    Wazwaz, Abdul-Majid

    2010-10-01

    In this work, the Korteweg-de Vries (KdV) equation with higher-order corrections is examined. We studied the KdV equation with first-order correction and that with second-order correction that include the terms of the fifth-order Lax, Sawada-Kotera and Caudrey-Dodd-Gibbon equations. The simplified form of the bilinear method was used to show the integrability of the first-order models and therefore to obtain multiple soliton solutions for each one. The obstacles to integrability of some of the models with second-order corrections are examined as well.

  11. Pattern dynamics and filamentation of femtosecond terawatt laser pulses in air including the higher-order Kerr effects.

    PubMed

    Huang, T W; Zhou, C T; He, X T

    2013-05-01

    Plasma defocusing and higher-order Kerr effects on multiple filamentation and pattern formation of ultrashort laser pulse propagation in air are investigated. Linear analyses and numerical results show that these two saturable nonlinear effects can destroy the coherent evolution of the laser field, and small-scale spatial turbulent structures rapidly appear. For the two-dimensional case, numerical simulations show that blow-up-like solutions, spatial chaos, and pseudorecurrence can appear at higher laser intensities if only plasma defocusing is included. These complex patterns result from the stochastic evolution of the higher- or shorter-wavelength modes of the laser light spectrum. From the viewpoint of nonlinear dynamics, filamentation can be attributed to the modulational instability of these spatial incoherent localized structures. Furthermore, filament patterns associated with multiphoton ionization of the air molecules with and without higher-order Kerr effects are compared. PMID:23767639

  12. Effective higher-order nonlinear coefficients of composites with weakly nonlinear media

    NASA Astrophysics Data System (ADS)

    Natenapit, Mayuree; Thongboonrithi, Chaivej

    2010-05-01

    The field equations, based on the third-order perturbation expansion of electrostatic potential, are derived, and our general formulae for higher-order effective nonlinear coefficients based on the energy definition, are presented and applied to dielectric composites consisting of dilute linear cylindrical inclusions randomly dispersed in a weakly nonlinear host media. The effective nonlinear coefficients are determined up to the ninth order. In addition, the results are also compared to those obtained using the average field method and likely to provide more accurate predictions of effective higher-order nonlinear responses.

  13. Higher order corrections and unification in the minimal supersymmetric standard model: SOFTSUSY3.5

    NASA Astrophysics Data System (ADS)

    Allanach, B. C.; Bednyakov, A.; Ruiz de Austri, R.

    2015-04-01

    We explore the effects of three-loop minimal supersymmetric standard model renormalisation group equation terms and some leading two-loop threshold corrections on gauge and Yukawa unification: each being one loop higher order than current public spectrum calculators. We also explore the effect of the higher order terms (often 2-3 GeV) on the lightest CP even Higgs mass prediction. We illustrate our results in the constrained minimal supersymmetric standard model. Neglecting threshold corrections at the grand unified scale, the discrepancy between the unification scale αs and the other two unified gauge couplings changes by 0.1% due to the higher order corrections and the difference between unification scale bottom-tau Yukawa couplings neglecting unification scale threshold corrections changes by up to 1%. The difference between unification scale bottom and top Yukawa couplings changes by a few percent. Differences due to the higher order corrections also give an estimate of the size of theoretical uncertainties in the minimal supersymmetric standard model spectrum. We use these to provide estimates of theoretical uncertainties in predictions of the dark matter relic density (which can be of order one due to its strong dependence on sparticle masses) and the LHC sparticle production cross-section (often around 30%). The additional higher order corrections have been incorporated into SOFTSUSY, and we provide details on how to compile and use the program. We also provide a summary of the approximations used in the higher order corrections.

  14. Evidence of higher-order effects in thermally driven rapid granular flows

    NASA Astrophysics Data System (ADS)

    Hrenya, C. M.; Galvin, J. E.; Wildman, R. D.

    Molecular dynamic (MD) simulations are used to probe the ability of Navier heat flux, stress tensor and dissipation rate - associated with granular materials. The system under investigation is bounded by two opposite walls of set granular temperature and is characterized by zero mean flow. The comparisons between MD and theory provide evidence of higher-order effects in each of the constitutive quantities. Furthermore, the size of these effects is roughly one order of magnitude greater, on a percentage basis, for heat flux than it is for stress or dissipation rate. For the case of heat flux, these effects are attributed to super-Burnett-order contributions (third order in gradients) or greater, since Burnett-order contributions to the heat flux do not exist. Finally, for the system considered, these higher-order contributions to the heat flux outweigh the first-order contribution arising from a gradient in concentration (i.e. the Dufour effect)

  15. Lateral resolution improvement in scanning nonlinear dielectric microscopy by measuring super-higher-order nonlinear dielectric constants

    NASA Astrophysics Data System (ADS)

    Chinone, N.; Yamasue, K.; Hiranaga, Y.; Honda, K.; Cho, Y.

    2012-11-01

    Scanning nonlinear dielectric microscopy (SNDM) can be used to visualize polarization distributions in ferroelectric materials and dopant profiles in semiconductor devices. Without using a special sharp tip, we achieved an improved lateral resolution in SNDM through the measurement of super-higher-order nonlinearity up to the fourth order. We observed a multidomain single crystal congruent LiTaO3 (CLT) sample, and a cross section of a metal-oxide-semiconductor (MOS) field-effect-transistor (FET). The imaged domain boundaries of the CLT were narrower in the super-higher-order images than in the conventional image. Compared to the conventional method, the super-higher-order method resolved the more detailed structure of the MOSFET.

  16. Word Order and Thematic Structure in Mandarin.

    ERIC Educational Resources Information Center

    Yoon, James H.

    Recent proposals concerning the relationship between thematic structure and syntactic structure, including the idea of thematic hierarchy, when used with certain language-specific properties, offer insight into some problems concerning the Mandarin Chinese phrase structure condition (PSC). The PSC is such that the internal structure of XP contains…

  17. Multiple sextupole system for the correction of third and higher order aberration

    DOEpatents

    Crewe, Albert V.

    1983-01-01

    A means is provided for compensating for third and higher order aberration in charged particle beam devices. The means includes two sextupoles with an intermediate focusing lens, all positioned between two focusing lenses.

  18. Higher-order corrections to dust ion-acoustic soliton in a quantum dusty plasma

    SciTech Connect

    Chatterjee, Prasanta; Das, Brindaban; Mondal, Ganesh; Muniandy, S. V.; Wong, C. S.

    2010-10-15

    Dust ion-acoustic soliton is studied in an electron-dust-ion plasma by employing a two-fluid quantum hydrodynamic model. Ions and electrons are assumed to follow quantum mechanical behaviors in dust background. The Korteweg-de Vries (KdV) equation and higher order contribution to KdV equations are derived using reductive perturbation technique. The higher order contribution is obtained as a higher order inhomogeneous differential equation. The nonsecular solution of the higher order contribution is obtained by using the renormalization method and the particular solution of the inhomogeneous equation is determined using a truncated series solution method. The effects of dust concentration, quantum parameter for ions and electrons, and soliton velocity on the amplitude and width of the dressed soliton are discussed.

  19. Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas.

    PubMed

    Zembrzycki, Andreas; Stocker, Adam M; Leingärtner, Axel; Sahara, Setsuko; Chou, Shen-Ju; Kalatsky, Valery; May, Scott R; Stryker, Michael P; O'Leary, Dennis Dm

    2015-01-01

    In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical areas may disrupt sensory function and behavior. Developmental genetic mechanisms specify primary areas, but mechanisms influencing higher order area properties are unknown. By exploiting gain-of and loss-of function mouse models of the transcription factor Emx2, we have generated bi-directional changes in primary visual cortex size in vivo and have used it as a model to show a novel and prominent function for genetic mechanisms regulating primary visual area size and also proportionally dictating the sizes of surrounding higher order visual areas. This finding redefines the role for intrinsic genetic mechanisms to concomitantly specify and scale primary and related higher order sensory areas in a linear fashion. PMID:26705332

  20. Fusions as a Source of Information on Higher-Order Influences Upon Speech Perception. CUNYForum, No. 4, 1978.

    ERIC Educational Resources Information Center

    Cowart, Wayne

    This paper suggests that some features of the syntactic and semantic structure of sentences sometimes influence the phonemic analyses assigned to stretches of speech by the perceptual system. It is argued that the role of higher-order levels of linguistic analysis in speech perception can be productively studied. Theoretical issues appropriate for…

  1. Higher order mode of a microstripline fed cylindrical dielectric resonator antenna

    NASA Astrophysics Data System (ADS)

    Kumar, A. V. Praveen

    2016-03-01

    A microstrip transmission line can be used to excite the broadside radiating mode of a cylindrical dielectric resonator antenna (CDRA). The same is found to excite considerably well a higher order mode (HOM) as well. However unlike the broadside mode, the higher order mode gives distorted radiation pattern which makes this mode less useful for practical applications. The cause of distortion in the HOM radiation and the dependence of HOM coupling on the microstrip feed line are explored using HFSS simulations.

  2. Regularity properties of fiber derivatives associated with higher-order mechanical systems

    NASA Astrophysics Data System (ADS)

    Colombo, Leonardo; Prieto-Martínez, Pedro Daniel

    2016-08-01

    The aim of this work is to study fiber derivatives associated to Lagrangian and Hamiltonian functions describing the dynamics of a higher-order autonomous dynamical system. More precisely, given a function in T∗T(k-1)Q, we find necessary and sufficient conditions for such a function to describe the dynamics of a kth-order autonomous dynamical system, thus being a kth-order Hamiltonian function. Then, we give a suitable definition of (hyper)regularity for these higher-order Hamiltonian functions in terms of their fiber derivative. In addition, we also study an alternative characterization of the dynamics in Lagrangian submanifolds in terms of the solutions of the higher-order Euler-Lagrange equations.

  3. Study of higher order non-classical properties of squeezed Kerr state

    NASA Astrophysics Data System (ADS)

    Mishra, Devendra Kumar

    2010-09-01

    Recently, Prakash and Mishra [J. Phys. B: at. Mol. Opt. Phys., 39, 2291(2006); 40, 2531(2007)] have studied higher order sub-Poissonian photon statistic conditions for non-classicality in the form of general inequalities for expectation values of products of arbitrary powers of photon number and of photon-number fluctuation. It is, therefore, vital to study the generation of these higher order sub-Poissonian photon statistics (phase-insensitive behavior) in a physically realizable medium and their relations to higher order squeezing (phase-sensitive behavior). In the present paper, we study higher order non-classical properties, such as Hong and Mandel squeezing, amplitude-squared squeezing and higher order sub-Poissonian photon statistics, of squeezed Kerr state which is generated by squeezing the output of a Kerr medium whose input is coherent light. Such states can be realized if laser light is sent through an optical fiber and then into a degenerate parametric amplifier. It is established that the squeezed Kerr state can exhibit higher order non-classical properties.

  4. Fast algorithm for scaling analysis with higher-order detrending moving average method

    NASA Astrophysics Data System (ADS)

    Tsujimoto, Yutaka; Miki, Yuki; Shimatani, Satoshi; Kiyono, Ken

    2016-05-01

    Among scaling analysis methods based on the root-mean-square deviation from the estimated trend, it has been demonstrated that centered detrending moving average (DMA) analysis with a simple moving average has good performance when characterizing long-range correlation or fractal scaling behavior. Furthermore, higher-order DMA has also been proposed; it is shown to have better detrending capabilities, removing higher-order polynomial trends than original DMA. However, a straightforward implementation of higher-order DMA requires a very high computational cost, which would prevent practical use of this method. To solve this issue, in this study, we introduce a fast algorithm for higher-order DMA, which consists of two techniques: (1) parallel translation of moving averaging windows by a fixed interval; (2) recurrence formulas for the calculation of summations. Our algorithm can significantly reduce computational cost. Monte Carlo experiments show that the computational time of our algorithm is approximately proportional to the data length, although that of the conventional algorithm is proportional to the square of the data length. The efficiency of our algorithm is also shown by a systematic study of the performance of higher-order DMA, such as the range of detectable scaling exponents and detrending capability for removing polynomial trends. In addition, through the analysis of heart-rate variability time series, we discuss possible applications of higher-order DMA.

  5. Strategic Learning in Youth with Traumatic Brain Injury: Evidence for Stall in Higher-Order Cognition

    ERIC Educational Resources Information Center

    Gamino, Jacquelyn F.; Chapman, Sandra B.; Cook, Lori G.

    2009-01-01

    Little is known about strategic learning ability in preteens and adolescents with traumatic brain injury (TBI). Strategic learning is the ability to combine and synthesize details to form abstracted gist-based meanings, a higher-order cognitive skill associated with frontal lobe functions and higher classroom performance. Summarization tasks were…

  6. Higher-order asymptotics and critical indexes in the ϕ3 theory

    NASA Astrophysics Data System (ADS)

    Kalagov, G. A.; Nalimov, M. Yu.

    2014-07-01

    Instanton analysis is applied to the scalar ϕ3 theory. Higher-order asymptotic expansions of the renormalization constants in the minimal subtraction scheme and 6-ɛ dimensional regularization and of the index η are found. Results of the Borel resummation for the presently known terms of the ɛ-expansion of the index η up to the order ɛ4 are presented.

  7. Encouraging Higher-Order Thinking in General Chemistry by Scaffolding Student Learning Using Marzano's Taxonomy

    ERIC Educational Resources Information Center

    Toledo, Santiago; Dubas, Justin M.

    2016-01-01

    An emphasis on higher-order thinking within the curriculum has been a subject of interest in the chemical and STEM literature due to its ability to promote meaningful, transferable learning in students. The systematic use of learning taxonomies could be a practical way to scaffold student learning in order to achieve this goal. This work proposes…

  8. Development of a Process To Assess Higher Order Thinking Skills for College Graduates.

    ERIC Educational Resources Information Center

    Rock, Donald A.

    Issues in the development of assessments of higher order thinking skills for college graduates are discussed in the order in which they were presented when this series of papers was commissioned. With regard to Issue 1, it is generally agreed that the development of these skills is a desirable goal, but there is little consensus on how they should…

  9. Efficient nonlinear generation of high power, higher order, ultrafast "perfect" vortices in green.

    PubMed

    Apurv Chaitanya, N; Jabir, M V; Samanta, G K

    2016-04-01

    We report on efficient nonlinear generation of ultrafast, higher order "perfect" vortices at the green wavelength. Based on Fourier transformation of the higher order Bessel-Gauss (BG) beam generated through the combination of the spiral phase plate and axicon, we have transformed the Gaussian beam of the ultrafast Yb-fiber laser at 1060 nm into perfect vortices of power 4.4 W and order up to 6. Using single-pass second-harmonic generation (SHG) of such vortices in 5 mm long chirped MgO-doped, periodically poled congruent LiNbO3 crystal, we have generated perfect vortices at green wavelength (530 nm) with output power of 1.2 W and vortex order up to 12 at a single-pass conversion efficiency of 27%, independent of the orders. This is the highest single-pass SHG efficiency of any optical beams other than Gaussian beams. Unlike the disintegration of higher order vortices due to spatial walk-off effect in birefringent crystals, here, the use of the quasi-phase-matching process enables generation of high-quality vortices, even at higher orders. The green perfect vortices of all orders have temporal and spectral widths of 507 fs and 1.9 nm, respectively, corresponding to a time-bandwidth product of 1.02. PMID:27192233

  10. Higher Order, Critical Thinking Skills in National Police Academy Course Development

    ERIC Educational Resources Information Center

    Barker, Beth A.

    2011-01-01

    Law enforcement requires the officer to invoke reason and critical thinking skills in order to solve intricate problems in real time, on the job. This study examined the course development of a large national organization (State Police Academies) to ascertain what strategies are being used in their courses to promote training for higher order,…

  11. Higher Order Cumulant Studies of Ocean Surface Random Fields from Satellite Altimeter Data

    NASA Technical Reports Server (NTRS)

    Cheng, B.

    1996-01-01

    Higher order statistics, especially 2nd order statistics, have been used to study ocean processes for many years in the past, and occupy an appreciable part of the research literature on physical oceanography. They in turn form part of a much larger field of study in statistical fluid mechanics.

  12. A wireless and passive pressure sensor system based on the magnetic higher-order harmonic field

    NASA Astrophysics Data System (ADS)

    Tan, Ee Lim

    The goal of this work is to develop a magnetic-based passive and wireless pressure sensor for use in biomedical applications. Structurally, the pressure sensor, referred to as the magneto-harmonic pressure sensor, is composed of two magnetic elements: a magnetically-soft material acts as a sensing element, and a magnetically hard material acts as a biasing element. Both elements are embedded within a rigid sensor body and sealed with an elastomer pressure membrane. Upon excitation of an externally applied AC magnetic field, the sensing element is capable of producing higher-order magnetic signature that is able to be remotely detected with an external receiving coil. When exposed to environment with changing ambient pressure, the elastomer pressure membrane of pressure sensor is deflected depending on the surrounding pressure. The deflection of elastomer membrane changes the separation distance between the sensing and biasing elements. As a result, the higher-order harmonic signal emitted by the magnetically-soft sensing element is shifted, allowing detection of pressure change by determining the extent of the harmonic shifting. The passive and wireless nature of the sensor is enabled with an external excitation and receiving system consisting of an excitation coil and a receiving coil. These unique characteristics made the sensor suitable to be used for continuous and long-term pressure monitoring, particularly useful for biomedical applications which often require frequent surveillance. In this work, abdominal aortic aneurysm is selected as the disease model for evaluation the performance of pressure sensor and system. Animal model, with subcutaneous sensor implantation in mice, was conducted to demonstrate the efficacy and feasibility of pressure sensor in biological environment.

  13. Effect of Higher-Order Spherical Aberration Term on Transfer Function in Electron Microscopy

    NASA Astrophysics Data System (ADS)

    Uchida, Yuji; Fujimoto, Fuminori

    1986-04-01

    The effect of the higher-order spherical aberration coefficient on the transfer function in transmission electron microscopy was calculated. In order to simplify the system, the optical illumination system was assumed to be perfectly coherent and axially symmetric. The result shows that the effect of the fifth-order spherical aberration coefficient, C5, on the usual transfer function with the third-order spherical aberration coefficient Cs\\equivC3{=}0.5 mm for 100 keV electrons cannot be neglected, if high-order Bragg reflections from net planes with smaller lattice spacings than 0.1 nm are utilized for lattice imaging. The effect of the higher-order term due to the defocussing on the transfer function is also discussed.

  14. Numerical simulation of stratified shear flow using a higher order Taylor series expansion method

    SciTech Connect

    Iwashige, Kengo; Ikeda, Takashi

    1995-09-01

    A higher order Taylor series expansion method is applied to two-dimensional numerical simulation of stratified shear flow. In the present study, central difference scheme-like method is adopted for an even expansion order, and upwind difference scheme-like method is adopted for an odd order, and the expansion order is variable. To evaluate the effects of expansion order upon the numerical results, a stratified shear flow test in a rectangular channel (Reynolds number = 1.7x10{sup 4}) is carried out, and the numerical velocity and temperature fields are compared with experimental results measured by laser Doppler velocimetry thermocouples. The results confirm that the higher and odd order methods can simulate mean velocity distributions, root-mean-square velocity fluctuations, Reynolds stress, temperature distributions, and root-mean-square temperature fluctuations.

  15. Higher order visual input to the mushroom bodies in the bee, Bombus impatiens

    PubMed Central

    Paulk, Angelique C.; Gronenberg, Wulfila

    2008-01-01

    To produce appropriate behaviors based on biologically relevant associations, sensory pathways conveying different modalities are integrated by higher-order central brain structures, such as insect mushroom bodies. To address this function of sensory integration, we characterized the structure and response of optic lobe neurons projecting to the calyces of the mushroom bodies in bees. Bees are well known for their visual learning and memory capabilities and their brains possess major direct visual input from the optic lobes to the mushroom bodies. To functionally characterize these visual inputs to the mushroom bodies, we recorded intracellularly from neurons in bumblebees (Apidae: Bombus impatiens) and a single neuron in a honeybee (Apidae: Apis mellifera) while presenting color and motion stimuli. All of the mushroom body input neurons were color sensitive while a subset was motion sensitive. Additionally, most of the mushroom body input neurons would respond to the first, but not to subsequent, presentations of repeated stimuli. In general, the medulla or lobula neurons projecting to the calyx signaled specific chromatic, temporal, and motion features of the visual world to the mushroom bodies, which included sensory information required for the biologically relevant associations bees form during foraging tasks. PMID:18635397

  16. Perceptual information for the age level of faces as a higher order invariant of growth.

    PubMed

    Pittenger, J B; Shaw, R E; Mark, L S

    1979-08-01

    Previous work supports the hypothesis that cardioidal strain, a nonlinear topological transformation, offers a plausible mathematical model for the perceived global changes in human craniofacial morphology due to growth. Experiment 1 examined the generality of the effect of this growth transformation on relative age judgments by applying it to profiles of a dog, bird, and monkey. Experiment 2 investigated the abstractness of this transformation by looking at its effect on perceived age level of a Volkswagen "Beetle." In both experiments, cardioidal strain resulted in changes in the perceived age of the nonhuman profiles that were similar to those produced on human faces in earlier work. A second transformation, affine shear, failed to produce as significant an effect on perceived age as cardioidal strain when applied to the same structures. Because cardioidal strain produces changes in structures that do not share an isomorphism of rigid (Euclidian) local features or rigid feature configurations, this transformation seems both sufficiently general and abstract to specify what J.J. Gibson has called a "higher-order invariant of perceptual information. PMID:528953

  17. Higher-order symmetry energy of nuclear matter and the inner edge of neutron star crusts

    NASA Astrophysics Data System (ADS)

    Seif, W. M.; Basu, D. N.

    2014-02-01

    The parabolic approximation to the equation of state of the isospin asymmetric nuclear matter (ANM) is widely used in the literature to make predictions for the nuclear structure and the neutron star properties. Based on the realistic M3Y-Paris and M3Y-Reid nucleon-nucleon interactions, we investigate the effects of the higher-order symmetry energy on the proton fraction in neutron stars and the location of the inner edge of their crusts and their core-crust transition density and pressure, thermodynamically. Analytical expressions for different-order symmetry energy coefficients of ANM are derived using the realistic interactions mentioned above. It is found that the higher-order terms of the symmetry-energy coefficients up to its eighth order (Esym8) contributes substantially to the proton fraction in β-stable neutron star matter at different nuclear matter densities, the core-crust transition density and pressure. Even by considering the symmetry-energy coefficients up to Esym8, we obtain a significant change of about 40% in the transition pressure value from the one based on the exact equation of state. The slope parameters of the symmetry energies for the M3Y-Paris (Reid) interaction, at the saturation density, are L =47.51(50.98), L4=-0.47(-1.43), L6=0.58(0.67), and L8=0.126(0.133) MeV. Using equations of state based on both Paris and Reid effective interactions which provide saturation incompressibility of symmetric nuclear matter in the range of 220≤K0≤270 MeV, we estimate the ranges 0.090≤ρt≤0.095fm-3 and 0.49≤Pt≤0.59MeVfm-3 for the liquid-core-solid-crust transition density and pressure, respectively. The corresponding range of the proton fraction obtained at this ρt range is 0.029≤xp (t)≤0.032.

  18. Spectral Line Profile Analysis Using Higher Diffraction Order in Vacuum Ultraviolet Region

    SciTech Connect

    Machida, M.; Daltrini, A. M.; Severo, J. H. F.; Nascimento, I. C.; Sanada, E. K.; Elizondo, J. I.; Kuznetsov, Y. K.; Galvao, R. M. O.

    2008-04-07

    Using a one meter VUV spectrometer and a MCP coupled to a CCD detector on TCABR tokamak, ion temperatures from impurity species have been measured and much better spectral resolution was obtained using higher order diffraction lines. Due to very small Doppler effect in the VUV region compared to large instrumental broadening, ion temperatures obtained from first order diffraction present large errors. The use of second, third and fourth order diffraction emissions increases the line broadening and results in lower error temperature measurements.

  19. Construction of classical superintegrable systems with higher order integrals of motion from ladder operators

    SciTech Connect

    Marquette, Ian

    2010-07-15

    We construct integrals of motion for multidimensional classical systems from ladder operators of one-dimensional systems. This method can be used to obtain new systems with higher order integrals. We show how these integrals generate a polynomial Poisson algebra. We consider a one-dimensional system with third order ladder operators and found a family of superintegrable systems with higher order integrals of motion. We obtain also the polynomial algebra generated by these integrals. We calculate numerically the trajectories and show that all bounded trajectories are closed.

  20. The effect of carbon concentration and plastic deformation on ultrasonic higher order elastic properties of steel

    NASA Technical Reports Server (NTRS)

    Heyman, J. S.; Allison, S. G.; Salama, K.

    1985-01-01

    The behavior of higher order elastic properties, which are much more sensitive to material state than are second order properties, has been studied for steel alloys AISI 1016, 1045, 1095, and 8620 by measuring the stress derivative of the acoustic natural velocity to determine the stress acoustic constants (SAC's). Results of these tests show a 20 percent linear variation of SAC's with carbon content as well as even larger variations with prestrain (plastic deformation). The use of higher order elastic characterization permits quantitative evaluation of solids and may prove useful in studies of fatigue and fracture.

  1. Higher-order suppression in an on-blaze plane-grating monochromator

    SciTech Connect

    Hunter, W.R.; Rife, J.C.

    1984-01-15

    The transmittance of an on-blaze plane-grating monochromator has been calculated as a function of wavelength for different spectral orders. The calculations show that higher, undesirable orders can be suppressed by a judicious selection of grating blaze angle and coating material. However, for intense sources, such as storage ring operating at high power and current, higher-order suppression due to blaze angle and coating material may have to be augmented by using transmitting filters or spectrally selective detectors or both.

  2. An efficient higher-order PML in WLP-FDTD method for time reversed wave simulation

    NASA Astrophysics Data System (ADS)

    Wei, Xiao-Kun; Shao, Wei; Ou, Haiyan; Wang, Bing-Zhong

    2016-09-01

    Derived from a stretched coordinate formulation, a higher-order complex frequency shifted (CFS) perfectly matched layer (PML) is proposed for the unconditionally stable finite-difference time-domain (FDTD) method based on weighted Laguerre polynomials (WLPs). The higher-order PML is implemented with an auxiliary differential equation (ADE) approach. In order to further improve absorbing performance, the parameter values of stretching functions in the higher-order PML are optimized by the multi-objective genetic algorithm (MOGA). The optimal solutions can be chosen from the Pareto front for trading-off between two independent objectives. It is shown in a numerical test that the higher-order PML is efficient in terms of attenuating propagating waves and reducing late time reflections. Moreover, the higher-order PML can be placed very close to the wall when analyzing the channel characteristics of time reversal (TR) waves in a multipath indoor environment. Numerical examples of TR wave propagation demonstrate the availability of the proposed method.

  3. In vivo heterogeneous tomographic bioluminescence imaging via a higher-order approximation forward model

    NASA Astrophysics Data System (ADS)

    Liu, Kai; Tian, Jie, Sr.; Qin, Chenghu; Yang, Xin; Zhu, Shouping; Han, Dong; Wu, Ping; Dai, Xiaoqian

    2011-03-01

    In vivo bioluminescence imaging (BLI) has played a more and more important role in biomedical research of small animals. Tomographic bioluminescence imaging (TBI) further translates the BLI optical information into three-dimensional bioluminescent source distribution, which could greatly facilitate applications in related studies. Although the diffusion approximation (DA) is one of the most widely-used forward models, higher-order approximations are still needed for in vivo small animal imaging. In this work, as a relatively accurate and higher-order approximation theory, a simplified spherical harmonics approximation (SPN) is applied for heterogeneous tomographic bioluminescence imaging in vivo. Furthermore, coupled with the SPN, a generalized graph cuts optimization approach is utilized, making BLT reconstructions fast and suit for the whole body of small animals. Heterogeneous in vivo experimental reconstructions via the higher-order approximation model demonstrate higher tomographic imaging quality, which is shown the capability for practical biomedical tomographic imaging applications.

  4. Design and Application of Strategies/Tactics in Higher Order Logics

    NASA Technical Reports Server (NTRS)

    Archer, Myla (Editor); diVito, Ben (Editor); Munoz, Cesar (Editor)

    2003-01-01

    This Proceedings includes both a paper from the implementors of PVS providing guidance for PVS strategy writers and a tutorial on PVS strategy writing distilled from the experience of three PVS users who have written extensive sets of PVS user strategies. Following these are three full papers from the higher-order logic theorem proving community that discuss PVS strategies to enhance arithmetic and other interactive reasoning in PVS; implementing first-order tactics in higher-order provers; and a proposed technique for specifying small step semantics that can be used in multiple higher order logic theorem provers, with illustrations from both Coq and PVS. The Proceedings concludes with three position papers for a panel session that discuss three settings in which development of PVS strategies is worth while.

  5. Quasi suppression of higher-order diffractions with inclined rectangular apertures gratings

    PubMed Central

    Liu, Yuwei; Zhu, Xiaoli; Gao, Yulin; Zhang, Wenhai; Fan, Quanping; Wei, Lai; Yang, Zuhua; Zhang, Qiangqiang; Qian, Feng; Chen, Yong; He, Weihua; Wu, Yinzhong; Yan, Zhuoyang; Hua, Yilei; Zhao, Yidong; Cui, Mingqi; Qiu, Rong; Zhou, Weimin; Gu, Yuqiu; Zhang, Baohan; Xie, Changqing; Cao, Leifeng

    2015-01-01

    Advances in the fundamentals and applications of diffraction gratings have received much attention. However, conventional diffraction gratings often suffer from higher-order diffraction contamination. Here, we introduce a simple and compact single optical element, named inclined rectangular aperture gratings (IRAG), for quasi suppression of higher-order diffractions. We show, both in the visible light and soft x-ray regions, that IRAG can significantly suppress higher-order diffractions with moderate diffraction efficiency. Especially, as no support strut is needed to maintain the free-standing patterns, the IRAG is highly advantageous to the extreme-ultraviolet and soft x-ray regions. The diffraction efficiency of the IRAG and the influences of fabrication constraints are also discussed. The unique quasi-single order diffraction properties of IRAG may open the door to a wide range of photonic applications. PMID:26563588

  6. Higher-order cumulants and spectral kurtosis for early detection of subterranean termites

    NASA Astrophysics Data System (ADS)

    de la Rosa, Juan José González; Moreno Muñoz, Antonio

    2008-02-01

    This paper deals with termite detection in non-favorable SNR scenarios via signal processing using higher-order statistics. The results could be extrapolated to all impulse-like insect emissions; the situation involves non-destructive termite detection. Fourth-order cumulants in time and frequency domains enhance the detection and complete the characterization of termite emissions, non-Gaussian in essence. Sliding higher-order cumulants offer distinctive time instances, as a complement to the sliding variance, which only reveal power excesses in the signal; even for low-amplitude impulses. The spectral kurtosis reveals non-Gaussian characteristics (the peakedness of the probability density function) associated to these non-stationary measurements, specially in the near ultrasound frequency band. Contrasted estimators have been used to compute the higher-order statistics. The inedited findings are shown via graphical examples.

  7. Higher- and lower-order factor analyses of the Children's Behavior Questionnaire in early and middle childhood.

    PubMed

    Kotelnikova, Yuliya; Olino, Thomas M; Klein, Daniel N; Kryski, Katie R; Hayden, Elizabeth P

    2016-01-01

    The Children's Behavior Questionnaire (CBQ; Rothbart, Ahadi, & Hershey, 1994), a 195-item parent-report questionnaire, is one of the most widely used measures of child temperament, with previous analyses of its scales suggesting that 3 broad factors account for the overarching structure of child temperament (Rothbart, Ahadi, Hershey, & Fisher, 2001). However, there are no published item-level factor analyses of the CBQ, meaning that it is currently unclear whether items clearly load onto CBQ scales as proposed by its developers. Additionally, although the CBQ is intended to cover a broad window of development (i.e., ages 3-7), little is known about whether the structure of the CBQ differs depending on child age. The present study used a bottom-up approach to examine the lower- and higher-order structure of the CBQ in a large community sample of children at ages 3 (N = 944) and 5/6 (N = 853). Item-level exploratory factor analyses (EFAs) identified 88 items at age 3 and 87 items at age 5/6 suitable (i.e., with loadings ≥.40) for constructing lower-order factors. Of the lower-order factors derived at ages 3 and 5/6, fewer than half resembled original CBQ scales (Rothbart et al., 1994, 2001). Higher-order EFAs of the lower-order factors suggested that a 4-factor structure was the best fit at both ages 3 and 5/6. Thus, results indicate that a substantial number of CBQ items do not load well on a lower-order factor and that more than 3 factors are needed to account for its higher-order structure. PMID:26029946

  8. Bounding higher-order ionosphere errors for the dual-frequency GPS user

    NASA Astrophysics Data System (ADS)

    Datta-Barua, S.; Walter, T.; Blanch, J.; Enge, P.

    2008-10-01

    Civil signals at L2 and L5 frequencies herald a new phase of Global Positioning System (GPS) performance. Dual-frequency users typically assume a first-order approximation of the ionosphere index of refraction, combining the GPS observables to eliminate most of the ranging delay, on the order of meters, introduced into the pseudoranges. This paper estimates the higher-order group and phase errors that occur from assuming the ordinary first-order dual-frequency ionosphere model using data from the Federal Aviation Administration's Wide Area Augmentation System (WAAS) network on a solar maximum quiet day and an extremely stormy day postsolar maximum. We find that during active periods, when ionospheric storms may introduce slant range delays at L1 as high as 100 m, the higher-order group errors in the L1-L2 or L1-L5 dual-frequency combination can be tens of centimeters. The group and phase errors are no longer equal and opposite, so these errors accumulate in carrier smoothing of the dual-frequency code observable. We show the errors in the carrier-smoothed code are due to higher-order group errors and, to a lesser extent, to higher-order phase rate errors. For many applications, this residual error is sufficiently small as to be neglected. However, such errors can impact geodetic applications as well as the error budgets of GPS Augmentation Systems providing Category III precision approach.

  9. A critical study of higher-order numerical methods for solving the boundary-layer equations

    NASA Technical Reports Server (NTRS)

    Wornom, S. F.

    1977-01-01

    A fourth-order box method is presented for calculating numerical solutions to parabolic, partial differential equations in two variables or ordinary differential equations. The method is the natural extension of the second-order Keller Box Scheme to fourth order and is demonstrated with application to the incompressible, laminar and turbulent boundary-layer equations. The efficiency of the present method is compared with other two-point and three-point higher-order methods; namely, the Keller Box Scheme with Richardson extrapolation, the method of deferred corrections, and the three-point spline methods. For equivalent accuracy, numerical results show the present method to be more efficient than the other higher-order methods for both laminar and turbulent flows.

  10. Critical study of higher order numerical methods for solving the boundary-layer equations

    NASA Technical Reports Server (NTRS)

    Wornom, S. F.

    1978-01-01

    A fourth order box method is presented for calculating numerical solutions to parabolic, partial differential equations in two variables or ordinary differential equations. The method, which is the natural extension of the second order box scheme to fourth order, was demonstrated with application to the incompressible, laminar and turbulent, boundary layer equations. The efficiency of the present method is compared with two point and three point higher order methods, namely, the Keller box scheme with Richardson extrapolation, the method of deferred corrections, a three point spline method, and a modified finite element method. For equivalent accuracy, numerical results show the present method to be more efficient than higher order methods for both laminar and turbulent flows.

  11. Application of higher-order numerical methods to the boundary-layer equations

    NASA Technical Reports Server (NTRS)

    Wornom, S. F.

    1978-01-01

    A fourth-order method is presented for calculating numerical solutions to parabolic, partial differential equations in two variables or ordinary differential equations. The method is the natural extension of the second-order Keller Box Scheme to fourth order and is demonstrated with application to the incompressible, laminar and turbulent boundary-layer equations for both attached and separated flows. The efficiency of the present method is compared with other higher-order methods; namely, the Keller Box Scheme with Richardson extrapolation, the method of deferred corrections, the three-point spline methods, and a modified finite-element method. For equivalent accuracy, numerical results show the present method to be more efficient than the other higher-order methods for both laminar and turbulent flows.

  12. On the asymptotic solutions of the KdV equation with higher-order corrections

    NASA Astrophysics Data System (ADS)

    Burde, Georgy I.

    2005-07-01

    A method for construction of new integrable PDEs, whose properties are related to an asymptotic perturbation expansion with the leading-order term given by an integrable equation, is developed. A new integrable equation is constructed by applying the properly defined Lie-Bäcklund group of transformations to the leading-order equation. The integrable equations related to the Korteweg-de Vries (KdV) equation with higher-order corrections are used to investigate the limits of applicability of the so-called asymptotic integrability concept. It is found that the solutions of the higher-order KdV equations obtained by a near identity transform from the normal form solitary waves cannot, in principle, describe some intrinsic features of the high-order KdV solitons.

  13. Higher order nonlocal formalism for linear analysis of a magnetized multispecies plasma with inhomogeneous flows

    SciTech Connect

    Gavrishchaka, V.V.; Ganguli, G.I.; Bakshi, P.M.; Koepke, M.E.

    1998-01-01

    The formalism necessary to study the collective properties of a plasma system with inhomogeneous flows is nonlocal and generally in the form of an integrodifferential equation. Usually the eigenvalue condition is reduced to a second-order differential equation for simplicity. While the gross physical behavior of the system can be obtained from the second-order differential equation level of description, higher-order corrections are necessary for greater accuracy. The limit in which the scale-size of the velocity inhomogeneity is large compared to the ion gyroradius is considered and a transverse flow profile sharply localized in space ({open_quotes}top-hat{close_quotes} profile) is assumed. In this limit, a simple analytical method for the solution of the general eigenvalue condition to all orders is developed. A comparison of the properties of the solutions obtained from the second-order differential equation level of description with those obtained from higher orders is presented. Both the resonant (dissipative) and the nonresonant (reactive) effects of velocity shear are considered. It is found that while the overall features are well represented by the second-order level of description, the higher-order corrections moderate the destabilizing effects due to velocity shear, which can be quite significant in some cases. {copyright} {ital 1998 American Institute of Physics.}

  14. Higher Order Analysis of Turbulent Changes Found in the ELF Range Electric Field Plasma Before Major Earthquakes

    NASA Astrophysics Data System (ADS)

    Kosciesza, M.; Blecki, J. S.; Parrot, M.

    2014-12-01

    We report the structure function analysis of changes found in electric field in the ELF range plasma turbulence registered in the ionosphere over epicenter region of major earthquakes with depth less than 40 km that took place during 6.5 years of the scientific mission of the DEMETER satellite. We compare the data for the earthquakes for which we found turbulence with events without any turbulent changes. The structure functions were calculated also for the Polar CUSP region and equatorial spread F region. Basic studies of the turbulent processes were conducted with use of higher order spectra and higher order statistics. The structure function analysis was performed to locate and check if there are intermittent behaviors in the ionospheres plasma over epicenter region of the earthquakes. These registrations are correlated with the plasma parameters measured onboard DEMETER satellite and with geomagnetic indices.

  15. A Maximum Entropy Test for Evaluating Higher-Order Correlations in Spike Counts

    PubMed Central

    Onken, Arno; Dragoi, Valentin; Obermayer, Klaus

    2012-01-01

    Evaluating the importance of higher-order correlations of neural spike counts has been notoriously hard. A large number of samples are typically required in order to estimate higher-order correlations and resulting information theoretic quantities. In typical electrophysiology data sets with many experimental conditions, however, the number of samples in each condition is rather small. Here we describe a method that allows to quantify evidence for higher-order correlations in exactly these cases. We construct a family of reference distributions: maximum entropy distributions, which are constrained only by marginals and by linear correlations as quantified by the Pearson correlation coefficient. We devise a Monte Carlo goodness-of-fit test, which tests - for a given divergence measure of interest - whether the experimental data lead to the rejection of the null hypothesis that it was generated by one of the reference distributions. Applying our test to artificial data shows that the effects of higher-order correlations on these divergence measures can be detected even when the number of samples is small. Subsequently, we apply our method to spike count data which were recorded with multielectrode arrays from the primary visual cortex of anesthetized cat during an adaptation experiment. Using mutual information as a divergence measure we find that there are spike count bin sizes at which the maximum entropy hypothesis can be rejected for a substantial number of neuronal pairs. These results demonstrate that higher-order correlations can matter when estimating information theoretic quantities in V1. They also show that our test is able to detect their presence in typical in-vivo data sets, where the number of samples is too small to estimate higher-order correlations directly. PMID:22685392

  16. Review of Alternative State-Level Higher Education Governance Structures.

    ERIC Educational Resources Information Center

    Oregon Univ. System, Eugene. Office of Academic Affairs.

    As part of the educational planning process, the Oregon State Board of Higher Education requested this review of alternative models for the Oregon University System (OUS). Staff of the Board of Higher Education synthesized existing literature on the variety of U.S. higher education governance structures, including newer models such as the public…

  17. Analysis of warping deformation modes using higher order ANCF beam element

    NASA Astrophysics Data System (ADS)

    Orzechowski, Grzegorz; Shabana, Ahmed A.

    2016-02-01

    Most classical beam theories assume that the beam cross section remains a rigid surface under an arbitrary loading condition. However, in the absolute nodal coordinate formulation (ANCF) continuum-based beams, this assumption can be relaxed allowing for capturing deformation modes that couple the cross-section deformation and beam bending, torsion, and/or elongation. The deformation modes captured by ANCF finite elements depend on the interpolating polynomials used. The most widely used spatial ANCF beam element employs linear approximation in the transverse direction, thereby restricting the cross section deformation and leading to locking problems. The objective of this investigation is to examine the behavior of a higher order ANCF beam element that includes quadratic interpolation in the transverse directions. This higher order element allows capturing warping and non-uniform stretching distribution. Furthermore, this higher order element allows for increasing the degree of continuity at the element interface. It is shown in this paper that the higher order ANCF beam element can be used effectively to capture warping and eliminate Poisson locking that characterizes lower order ANCF finite elements. It is also shown that increasing the degree of continuity requires a special attention in order to have acceptable results. Because higher order elements can be more computationally expensive than the lower order elements, the use of reduced integration for evaluating the stress forces and the use of explicit and implicit numerical integrations to solve the nonlinear dynamic equations of motion are investigated in this paper. It is shown that the use of some of these integration methods can be very effective in reducing the CPU time without adversely affecting the solution accuracy.

  18. Superintegrability and higher-order constants for classical and quantum systems

    NASA Astrophysics Data System (ADS)

    Kalnins, E. G.; Miller, W.; Pogosyan, G. S.

    2011-06-01

    We extend recent work by Tremblay, Turbiner, and Winternitz which analyzes an infinite family of solvable and integrable quantum systems in the plane, indexed by the positive parameter k. Key components of their analysis were to demonstrate that there are closed orbits in the corresponding classical system if k is rational, and for a number of examples there are generating quantum symmetries that are higher order differential operators than two. Indeed they conjectured that for a general class of potentials of this type, quantum constants of higher order should exist. We give credence to this conjecture by showing that for an even more general class of potentials in classicalmechanics, there are higher-order constants of the motion as polynomials in the momenta. Thus these systems are all superintegrable.

  19. Superintegrability and higher-order constants for classical and quantum systems

    SciTech Connect

    Kalnins, E. G.; Miller, W.; Pogosyan, G. S.

    2011-06-15

    We extend recent work by Tremblay, Turbiner, and Winternitz which analyzes an infinite family of solvable and integrable quantum systems in the plane, indexed by the positive parameter k. Key components of their analysis were to demonstrate that there are closed orbits in the corresponding classical system if k is rational, and for a number of examples there are generating quantum symmetries that are higher order differential operators than two. Indeed they conjectured that for a general class of potentials of this type, quantum constants of higher order should exist. We give credence to this conjecture by showing that for an even more general class of potentials in classicalmechanics, there are higher-order constants of the motion as polynomials in the momenta. Thus these systems are all superintegrable.

  20. Development of a Higher Order Laminate Theory for Modeling Composites with Induced Strain Actuators

    NASA Technical Reports Server (NTRS)

    Chattopadhyay, Aditi; Seeley, Charles E.

    1996-01-01

    A refined higher order plate theory is developed to investigate the actuation mechanism of piezoelectric materials surface bonded or embedded in composite laminates. The current analysis uses a displacement field which accurately accounts for transverse shear stresses. Some higher order terms are identified by using the conditions that shear stresses vanish at all free surfaces. Therefore, all boundary conditions for displacements and stresses are satisfied in the present theory. The analysis is implemented using the finite element method which provides a convenient means to construct a numerical solution due to the discrete nature of the actuators. The higher order theory is computationally less expensive than a full three dimensional analysis. The theory is also shown to agree well with published experimental results. Numerical examples are presented for composite plates with thicknesses ranging from thin to very thick.

  1. Temporal integration property of stereopsis after higher-order aberration correction

    PubMed Central

    Kang, Jian; Dai, Yun; Zhang, Yudong

    2015-01-01

    Based on a binocular adaptive optics visual simulator, we investigated the effect of higher-order aberration correction on the temporal integration property of stereopsis. Stereo threshold for line stimuli, viewed in 550nm monochromatic light, was measured as a function of exposure duration, with higher-order aberrations uncorrected, binocularly corrected or monocularly corrected. Under all optical conditions, stereo threshold decreased with increasing exposure duration until a steady-state threshold was reached. The critical duration was determined by a quadratic summation model and the high goodness of fit suggested this model was reasonable. For normal subjects, the slope for stereo threshold versus exposure duration was about −0.5 on logarithmic coordinates, and the critical duration was about 200 ms. Both the slope and the critical duration were independent of the optical condition of the eye, showing no significant effect of higher-order aberration correction on the temporal integration property of stereopsis. PMID:26601010

  2. A higher order visual neuron tuned to the spatial amplitude spectra of natural scenes

    PubMed Central

    Dyakova, Olga; Lee, Yu-Jen; Longden, Kit D.; Kiselev, Valerij G.; Nordström, Karin

    2015-01-01

    Animal sensory systems are optimally adapted to those features typically encountered in natural surrounds, thus allowing neurons with limited bandwidth to encode challengingly large input ranges. Natural scenes are not random, and peripheral visual systems in vertebrates and insects have evolved to respond efficiently to their typical spatial statistics. The mammalian visual cortex is also tuned to natural spatial statistics, but less is known about coding in higher order neurons in insects. To redress this we here record intracellularly from a higher order visual neuron in the hoverfly. We show that the cSIFE neuron, which is inhibited by stationary images, is maximally inhibited when the slope constant of the amplitude spectrum is close to the mean in natural scenes. The behavioural optomotor response is also strongest to images with naturalistic image statistics. Our results thus reveal a close coupling between the inherent statistics of natural scenes and higher order visual processing in insects. PMID:26439748

  3. Automatic tracking of ground station antennas by means of higher order waveguide modes

    NASA Astrophysics Data System (ADS)

    Scheffer, H.

    1980-02-01

    Utilization of higher order waveguide modes, which are excited in the feed when the satellite is displaced from the boresight axis of the antenna is discussed. The physical relations involved in the excitation of higher order waveguide modes as a function of the antenna position are explained. The starting points of these considerations are the radiation patterns of the tracking modes excited by feeds with circular and square cross sections. Special mention is made of the derivation of the offset information in the cases of circular and linear polarization of the beacon signal. The principle of selective mode coupling by means of tracking mode couplers is described. A compilation of German ground station antennas is given, which apply tracking by higher order waveguide modes.

  4. Temporal integration property of stereopsis after higher-order aberration correction.

    PubMed

    Kang, Jian; Dai, Yun; Zhang, Yudong

    2015-11-01

    Based on a binocular adaptive optics visual simulator, we investigated the effect of higher-order aberration correction on the temporal integration property of stereopsis. Stereo threshold for line stimuli, viewed in 550nm monochromatic light, was measured as a function of exposure duration, with higher-order aberrations uncorrected, binocularly corrected or monocularly corrected. Under all optical conditions, stereo threshold decreased with increasing exposure duration until a steady-state threshold was reached. The critical duration was determined by a quadratic summation model and the high goodness of fit suggested this model was reasonable. For normal subjects, the slope for stereo threshold versus exposure duration was about -0.5 on logarithmic coordinates, and the critical duration was about 200 ms. Both the slope and the critical duration were independent of the optical condition of the eye, showing no significant effect of higher-order aberration correction on the temporal integration property of stereopsis. PMID:26601010

  5. Structure and properties of "nematically ordered" aerogels

    NASA Astrophysics Data System (ADS)

    Asadchikov, V. E.; Askhadullin, R. Sh.; Volkov, V. V.; Dmitriev, V. V.; Kitaeva, N. K.; Martynov, P. N.; Osipov, A. A.; Senin, A. A.; Soldatov, A. A.; Chekrygina, D. I.; Yudin, A. N.

    2015-04-01

    The microstructure, specific area, and mechanical properties of various samples of "nematically ordered" aerogels whose strands are almost parallel to each other at macroscopic distances have been studied. The strong anisotropy of such aerogels distinguishes them from standard aerogels, which are synthesized by solgel technology, and opens new possibilities for physical experiments.

  6. Higher order concentration moments collapse in the expected mass fraction (EMF) based risk assessment

    NASA Astrophysics Data System (ADS)

    Srzic, Veljko; Gotovac, Hrvoje; Cvetkovic, Vladimir; Andricevic, Roko

    2014-05-01

    In this work Langrangian framework is used for conservative tracer transport simulations through 2-D extremely heterogeneous porous media. Conducted numerical simulations enable large sets of concentration values in both spatial and temporal domains. In addition to the advection, which acts on all scales, an additional mechanism considered is local scale dispersion (LSD), accounting for both mechanical dispersion and molecular diffusion. The ratio between these two mechanisms is quantified by the Peclet (Pe) number. In its base, the work gives answers to concentration scalar features when influenced by: i) different log-conductivity variance; ii) log-conductivity structures defined by the same global variogram but with different log conductivity patterns correlated; and iii) for a wide range of Peclet values. Results conducted by Monte Carlo analysis show a complex interplay between the aforementioned parameters, indicating the influence of aquifer properties to temporal LSD evolution. A remarkable collapse of higher order to second-order concentration moments [Yee, 2009] leads to the conclusion that only two concentration moments are required for an accurate description of concentration fluctuations. This explicitly holds for the pure advection case, while in the case of LSD presence the moment deriving function(MDF) is involved to ensure the moment collapse validity. An inspection of the Beta distribution leads to the conclusion that the two-parametric distribution can be used for concentration fluctuation characterization even in cases of high aquifer heterogeneity and/or for different log-conductivity structures, independent of the sampling volume used. Furthermore, the expected mass fraction (EMF) [Heagy & Sullivan, 1996] concept is applied in groundwater transport. In its origin, EMF is function of the concentration but with lower number of realizations needed for its determination, compared to the one point PDF. From practical point of view, EMF excludes

  7. Tensor based geology preserving reservoir parameterization with Higher Order Singular Value Decomposition (HOSVD)

    NASA Astrophysics Data System (ADS)

    Afra, Sardar; Gildin, Eduardo

    2016-09-01

    Parameter estimation through robust parameterization techniques has been addressed in many works associated with history matching and inverse problems. Reservoir models are in general complex, nonlinear, and large-scale with respect to the large number of states and unknown parameters. Thus, having a practical approach to replace the original set of highly correlated unknown parameters with non-correlated set of lower dimensionality, that captures the most significant features comparing to the original set, is of high importance. Furthermore, de-correlating system's parameters while keeping the geological description intact is critical to control the ill-posedness nature of such problems. We introduce the advantages of a new low dimensional parameterization approach for reservoir characterization applications utilizing multilinear algebra based techniques like higher order singular value decomposition (HOSVD). In tensor based approaches like HOSVD, 2D permeability images are treated as they are, i.e., the data structure is kept as it is, whereas in conventional dimensionality reduction algorithms like SVD data has to be vectorized. Hence, compared to classical methods, higher redundancy reduction with less information loss can be achieved through decreasing present redundancies in all dimensions. In other words, HOSVD approximation results in a better compact data representation with respect to least square sense and geological consistency in comparison with classical algorithms. We examined the performance of the proposed parameterization technique against SVD approach on the SPE10 benchmark reservoir model as well as synthetic channelized permeability maps to demonstrate the capability of the proposed method. Moreover, to acquire statistical consistency, we repeat all experiments for a set of 1000 unknown geological samples and provide comparison using RMSE analysis. Results prove that, for a fixed compression ratio, the performance of the proposed approach

  8. Extended monopole solution of the Blandford-Znajek mechanism: Higher order terms for a Kerr parameter

    SciTech Connect

    Tanabe, Kentarou; Nagataki, Shigehiro

    2008-07-15

    The Blandford-Znajek mechanism, by which the rotational energy of a black hole is extracted through electromagnetic fields, is one of the promising candidates as an essential process of the central engine of active compact objects such as gamma-ray bursts. The only known analytical solution of this mechanism is the perturbative monopole solution for Kerr parameter a up to the second order terms. In order to apply the Blandford-Znajek mechanism to rapidly rotating black holes, we try to obtain the perturbation solution up to the fourth order. As a result, we find that the fourth order terms of the vector potential diverge at infinity, and this implies that the perturbation approach breaks down at a large distance from the black hole. Although there are some uncertainties about the solution due to the unknown boundary condition at infinity for the fourth order terms, we can derive the evaluation of the total energy flux extracted from the black hole up to fourth order of a without any ambiguity. Furthermore, from the comparison between the numerical solution, which is valid for 0order solution, we find that the fourth order solution reproduces the numerical result better than the second order solution. At the same time, since the fourth order solution does not match well with the numerical result at large a, we conclude that more higher order terms are required to reproduce the numerical result.

  9. Higher order harmonic detection for exploring nonlinear interactions with nanoscale resolution

    PubMed Central

    Vasudevan, R. K.; Okatan, M. Baris; Rajapaksa, I.; Kim, Y.; Marincel, D.; Trolier-McKinstry, S.; Jesse, S.; Valanoor, N.; Kalinin, S. V.

    2013-01-01

    Nonlinear dynamics underpin a vast array of physical phenomena ranging from interfacial motion to jamming transitions. In many cases, insight into the nonlinear behavior can be gleaned through exploration of higher order harmonics. Here, a method using band excitation scanning probe microscopy (SPM) to investigate higher order harmonics of the electromechanical response, with nanometer scale spatial resolution is presented. The technique is demonstrated by probing the first three harmonics of strain for a Pb(Zr1-xTix)O3 (PZT) ferroelectric capacitor. It is shown that the second order harmonic response is correlated with the first harmonic response, whereas the third harmonic is not. Additionally, measurements of the second harmonic reveal significant deviations from Rayleigh-type models in the form of a much more complicated field dependence than is observed in the spatially averaged data. These results illustrate the versatility of nth order harmonic SPM detection methods in exploring nonlinear phenomena in nanoscale materials. PMID:24045269

  10. Higher-order numerical methods derived from three-point polynomial interpolation

    NASA Technical Reports Server (NTRS)

    Rubin, S. G.; Khosla, P. K.

    1976-01-01

    Higher-order collocation procedures resulting in tridiagonal matrix systems are derived from polynomial spline interpolation and Hermitian finite-difference discretization. The equations generally apply for both uniform and variable meshes. Hybrid schemes resulting from different polynomial approximations for first and second derivatives lead to the nonuniform mesh extension of the so-called compact or Pade difference techniques. A variety of fourth-order methods are described and this concept is extended to sixth-order. Solutions with these procedures are presented for the similar and non-similar boundary layer equations with and without mass transfer, the Burgers equation, and the incompressible viscous flow in a driven cavity. Finally, the interpolation procedure is used to derive higher-order temporal integration schemes and results are shown for the diffusion equation.

  11. Advantages and artifacts of higher order modes in nanoparticle-enhanced backscattering Raman imaging.

    PubMed

    Schultz, Zachary D; Stranick, Stephan J; Levin, Ira W

    2009-12-01

    In order to facilitate nanoparticle-enhanced Raman imaging of complicated biological specimens, we have examined the use of higher order modes with radial and azimuthal polarizations focused onto a Au nanoparticle atomic force microscope (AFM) tip utilizing a backscattering reflection configuration. When comparing the Raman intensity profiles with the observed sample topography, the radial-polarized configuration demonstrates enhanced spatial resolution. This enhanced resolution results from the direction of the induced electron oscillation in the metal nanoparticle oriented by the electromagnetic field at the laser focus. The electric field component along the direction of laser propagation, attendant to the radial polarization, creates an enhanced field along the z-axis and normal to the sample. Substantial enhancement is observed utilizing an intermediate numerical aperture objective (NA = 0.7), necessary for backscattering measurements. The azimuthal polarization, similar to linear polarization, results in an enhanced field predominantly parallel to the sample, resulting in imaging artifacts. The Raman intensity profiles observed as the exciting laser polarization is switched between either a radially polarized or an azimuthally polarized state illustrate these imaging artifacts. Because azimuthal polarization arises readily from changes in the incident polarization onto the mode converter, the results presented here aid in identifying such artifacts when analyzing nanoparticle-enhanced Raman spectroscopic images. Due to the power law decay of the enhanced field, an enhancement orientation normal to the sample enables contrast between structures smaller than the tip dimensions as the apex of the nanoparticle tip, where the enhancement is strongest, passes over the sample. These effects are demonstrated using both carbon nanotube and fixed biological samples. PMID:19947663

  12. Modulation instability in positive refractive metamaterials with higher-order dispersion and saturable nonlinearity

    NASA Astrophysics Data System (ADS)

    Zhong, Xian-qiong; Xiang, Wen-li; Cheng, Ke

    2013-11-01

    After taking the higher-order dispersion and three kinds of saturable nonlinearities into account, we investigate the characteristics of modulation instability (MI) in real units in the positive refractive region of metamaterials (MMs). The results show that the gain spectra of MI consist of two spectral regions, one of which is close to and the other is far from the zero point. In particular, the spectral region far from the zero point also has high cut-off frequency but narrow spectral width just as those revealed in the negative refractive region. Moreover, the gain spectra can change with the normalized angular frequency, the normalized optical power and the form of the saturable nonlinearity. Concretely, the spectral width increases with increase of the normalized angular frequency. But both of the spectral width and the peak gain increase and then decrease with increase of the normalized optical power. In other words, the MI characteristics and MI related applications can be controlled by adjusting the structure of the MMs, the form of the saturable nonlinearity and the normalized optical power.

  13. Functional independence in resting-state connectivity facilitates higher-order cognition.

    PubMed

    James, G Andrew; Kearney-Ramos, Tonisha E; Young, Jonathan A; Kilts, Clinton D; Gess, Jennifer L; Fausett, Jennifer S

    2016-06-01

    Growing evidence suggests that intrinsic functional connectivity (i.e. highly structured patterns of communication between brain regions during wakeful rest) may encode cognitive ability. However, the generalizability of these findings is limited by between-study differences in statistical methodology and cognitive domains evaluated. To address this barrier, we evaluated resting-state neural representations of multiple cognitive domains within a relatively large normative adult sample. Forty-four participants (mean(sd) age=31(10) years; 18 male and 26 female) completed a resting-state functional MRI scan and neuropsychological assessments spanning motor, visuospatial, language, learning, memory, attention, working memory, and executive function performance. Robust linear regression related cognitive performance to resting-state connectivity among 200 a priori determined functional regions of interest (ROIs). Only higher-order cognitions (such as learning and executive function) demonstrated significant relationships between brain function and behavior. Additionally, all significant relationships were negative - characterized by moderately positive correlations among low performers and weak to moderately negative correlations among high performers. These findings suggest that functional independence among brain regions at rest facilitates cognitive performance. Our interpretation is consistent with graph theoretic analyses which represent the brain as independent functional nodes that undergo dynamic reorganization with task demand. Future work will build upon these findings by evaluating domain-specific variance in resting-state neural representations of cognitive impairment among patient populations. PMID:27105037

  14. Triangular Alignment (TAME). A Tensor-based Approach for Higher-order Network Alignment

    SciTech Connect

    Mohammadi, Shahin; Gleich, David F.; Kolda, Tamara G.; Grama, Ananth

    2015-11-01

    Network alignment is an important tool with extensive applications in comparative interactomics. Traditional approaches aim to simultaneously maximize the number of conserved edges and the underlying similarity of aligned entities. We propose a novel formulation of the network alignment problem that extends topological similarity to higher-order structures and provide a new objective function that maximizes the number of aligned substructures. This objective function corresponds to an integer programming problem, which is NP-hard. Consequently, we approximate this objective function as a surrogate function whose maximization results in a tensor eigenvalue problem. Based on this formulation, we present an algorithm called Triangular AlignMEnt (TAME), which attempts to maximize the number of aligned triangles across networks. We focus on alignment of triangles because of their enrichment in complex networks; however, our formulation and resulting algorithms can be applied to general motifs. Using a case study on the NAPABench dataset, we show that TAME is capable of producing alignments with up to 99% accuracy in terms of aligned nodes. We further evaluate our method by aligning yeast and human interactomes. Our results indicate that TAME outperforms the state-of-art alignment methods both in terms of biological and topological quality of the alignments.

  15. Magnitude and significance of the higher-order reduced density matrix cumulants

    NASA Astrophysics Data System (ADS)

    Herbert, John M.

    Using full configuration interaction wave functions for Be and LiH, in both minimal and extended basis sets, we examine the absolute magnitude and energetic significance of various contributions to the three-electron reduced density matrix (3-RDM) and its connected (size-consistent) component, the 3-RDM cumulant (3-RDMC). Minimal basis sets are shown to suppress the magnitude of the 3-RDMC in an artificial manner, whereas in extended basis sets, 3-RDMC matrix elements are often comparable in magnitude to the corresponding 3-RDM elements, even in cases where this result is not required by spin angular momentum coupling. Formal considerations suggest that these observations should generalize to higher-order p-RDMs and p-RDMCs (p > 3). This result is discussed within the context of electronic structure methods based on the contracted Schrödinger equation (CSE), as solution of the CSE relies on 3- and 4-RDM ?reconstruction functionals? that neglect the 3-RDMC, the 4-RDMC, or both. Although the 3-RDMC is responsible for at most 0.2% of the total electronic energy in Be and LiH, it accounts for up to 70% of the correlation energy, raising questions regarding whether (and how) the CSE can offer a useful computational methodology.

  16. Wave train generation of solitons in systems with higher-order nonlinearities.

    PubMed

    Mohamadou, Alidou; LatchioTiofack, C G; Kofané, Timoléon C

    2010-07-01

    Considering the higher-order nonlinearities in a material can significantly change its behavior. We suggest the extended nonlinear Schrödinger equation to describe the propagation of ultrashort optical pulses through a dispersive medium with higher-order nonlinearities. Soliton trains are generated through the modulational instability and we point out the influence of the septic nonlinearity in the modulational instability gain. Experimental values are used for the numerical simulations and the input plane wave leads to the development of pulse trains, depending upon the sign of the septic nonlinearity. PMID:20866749

  17. Higher--order CO/sub 2/ laser beam spot size and depth of focus determined

    SciTech Connect

    Luxon, J.T.; Parker, D.E.

    1981-06-01

    Measurements of higher-order CO/sub 2/ laser beam spot size have been made and found in good agreement with a Hermite-Gaussian rectangular beam propagation model. A modified working definition of spot size is introduced, and a useful depth of focus relationship is presented. It is shown that a single measurement of spot size for any higher-order mode is all that is required to reasonably predict spot size for the same laser operating in different modes. Alternatively, beam size can be predicted theoretically on the basis of the optical cavity parameters.

  18. Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis

    NASA Astrophysics Data System (ADS)

    Yuan, Zhen; Zhang, Qizhi; Sobel, Eric; Jiang, Huabei

    2009-09-01

    In this study, a simplified spherical harmonics approximated higher order diffusion model is employed for 3-D diffuse optical tomography of osteoarthritis in the finger joints. We find that the use of a higher-order diffusion model in a stand-alone framework provides significant improvement in reconstruction accuracy over the diffusion approximation model. However, we also find that this is not the case in the image-guided setting when spatial prior knowledge from x-rays is incorporated. The results show that the reconstruction error between these two models is about 15 and 4%, respectively, for stand-alone and image-guided frameworks.

  19. Mixed Electromagnetic and Circuit Simulations using Higher-Order Elements and Bases

    SciTech Connect

    Champagne, N J; Rockway, J D; Jandhyala, V

    2003-06-18

    In this paper, an approach to couple higher-order electromagnetic surface integral equations to circuit simulations is presented. Terminals are defined that connect circuit elements to contacts modeled on the distributed electromagnetic domain. A modified charge-current continuity equation is proposed for a generalized KCL connection at the contacts. The distributive electromagnetic integral equations are developed using higher-order bases and elements that allow both better convergence and accuracy for modeling. The resulting scheme enables simultaneous solution of electromagnetic integral equations for arbitrarily-shaped objects and SPICE-like modeling for lumped circuits, and permits design iterations and visualization of the interaction between the two domains.

  20. Teaching biotechnology through case studies - can we improve higher order thinking skills of nonscience majors?

    NASA Astrophysics Data System (ADS)

    Dori, Yehudit J.; Tal, Revital T.; Tsaushu, Masha

    2003-11-01

    Teaching nonscience majors topics in biotechnology through case studies is the focus of this research. Our Biotechnology, Environment, and Related Issues module, developed within the Science for All framework, is aimed at elevating the level of students' scientific and technological literacy and their higher order thinking skills. The research goal was to investigate nonscience major students' ability to use various thinking skills in analyzing environmental and moral conflicts presented through case studies in the Biotechnology Module. The research population consisted of about 200 nonscience majors in eight classes of grades 10-12 from heterogeneous communities. We found a significant improvement in students' knowledge and understanding and higher order thinking skills at all academic levels. The scores that low academic level students achieved in the knowledge and understanding category were higher than their high academic level peers' scores. In the higher order thinking skills - question posing, argumentation, and system thinking - a significant difference in favor of the high academic level students was found. The gap that had existed between low and high academic level students narrowed. Most students reported that the biotechnological topics that they had studied were interesting and relevant. Based on these results, we advocate a curriculum that exposes students to scientific controversies through case studies with environmental and moral implications. Our research has shown that this approach is likely to contribute to developing scientific and technological literacy along with higher order thinking skills of nonscience majors.