Sample records for histamine symposium held

  1. Land Subsidence International Symposium held in Venice

    NASA Astrophysics Data System (ADS)

    The Third International Symposium on Land Subsidence was held March 18-25, 1984, in Venice, Italy. Sponsors were the Ground-Water Commission of the International Association of Hydrological Sciences (IAHS), the United Nations Educational, Scientific, and Cultural Organization (UNESCO), the Italian National Research Council (CNR), the Italian Regions of Veneto and Emilia-Romagna, the Italian Municipalities of Venice, Ravenna, and Modena, the Venice Province, and the European Research Office. Cosponsors included the International Association of Hydrogeologists (IAH), the International Society for Soil Mechanics and Foundation Engineering (ISSMFE), and the Association of Geoscientists for International Development (AGID).Organized within the framework of UNESCO's International Hydrological Program, the symposium brought together over 200 international interdisciplinary specialists in the problems of land subsidence due to fluid and mineral withdrawal. Because man's continuing heavy development of groundwater, gas, oil, and minerals is changing the natural regime and thus causing more and more subsiding areas in the world, there had been sufficient new land subsidence occurrence, problems, research, and remedial measures since the 1976 Second International Symposium held in Anaheim, California, to develop a most interesting program of nearly 100 papers from about 30 countries. The program consisted of papers covering case histories of fluid and mineral withdrawal, engineering theory and analysis, karst “sink-hole”-type subsidence, subsidence due to dewatering of organic deposits or due to application of water (hydrocompaction), instrumentation, legal, socioeconomic, and environmental effects of land subsidence, and remedial works.

  2. Histamine fish poisoning revisited.

    PubMed

    Lehane, L; Olley, J

    2000-06-30

    Histamine (or scombroid) fish poisoning (HFP) is reviewed in a risk-assessment framework in an attempt to arrive at an informed characterisation of risk. Histamine is the main toxin involved in HFP, but the disease is not uncomplicated histamine poisoning. Although it is generally associated with high levels of histamine (> or =50 mg/100 g) in bacterially contaminated fish of particular species, the pathogenesis of HFP has not been clearly elucidated. Various hypotheses have been put forward to explain why histamine consumed in spoiled fish is more toxic than pure histamine taken orally, but none has proved totally satisfactory. Urocanic acid, like histamine, an imidazole compound derived from histidine in spoiling fish, may be the "missing factor" in HFP. cis-Urocanic acid has recently been recognised as a mast cell degranulator, and endogenous histamine from mast cell degranulation may augment the exogenous histamine consumed in spoiled fish. HFP is a mild disease, but is important in relation to food safety and international trade. Consumers are becoming more demanding, and litigation following food poisoning incidents is becoming more common. Producers, distributors and restaurants are increasingly held liable for the quality of the products they handle and sell. Many countries have set guidelines for maximum permitted levels of histamine in fish. However, histamine concentrations within a spoiled fish are extremely variable, as is the threshold toxic dose. Until the identity, levels and potency of possible potentiators and/or mast-cell-degranulating factors are elucidated, it is difficult to establish regulatory limits for histamine in foods on the basis of potential health hazard. Histidine decarboxylating bacteria produce histamine from free histidine in spoiling fish. Although some are present in the normal microbial flora of live fish, most seem to be derived from post-catching contamination on board fishing vessels, at the processing plant or in the

  3. Histamine, histamine intoxication and intolerance.

    PubMed

    Kovacova-Hanuskova, E; Buday, T; Gavliakova, S; Plevkova, J

    2015-01-01

    Excessive accumulation of histamine in the body leads to miscellaneous symptoms mediated by its bond to corresponding receptors (H1-H4). Increased concentration of histamine in blood can occur in healthy individuals after ingestion of foods with high contents of histamine, leading to histamine intoxication. In individuals with histamine intolerance (HIT) ingestion of food with normal contents of histamine causes histamine-mediated symptoms. HIT is a pathological process, in which the enzymatic activity of histamine-degrading enzymes is decreased or inhibited and they are insufficient to inactivate histamine from food and to prevent its passage to blood-stream. Diagnosis of HIT is difficult. Multi-faced, non-specific clinical symptoms provoked by certain kinds of foods, beverages and drugs are often attributed to different diseases, such as allergy and food intolerance, mastocytosis, psychosomatic diseases, anorexia nervosa or adverse drug reactions. Correct diagnosis of HIT followed by therapy based on histamine-free diet and supplementation of diamine oxidase can improve patient's quality of life. Copyright © 2015 SEICAP. Published by Elsevier Espana. All rights reserved.

  4. Frontiers in Laser Cooling, Single-Molecule Biophysics, and Energy Science: Remarks from Steve Chu at the Scientific Symposium Held in his Honor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chu, Steve

    2008-08-30

    Steve Chu, director of Lawrence Berkeley National Laboratory and recipient of the 1997 Nobel Prize, presents a talk at Frontiers in Laser Cooling, Single-Molecule Biophysics and Energy Science, a scientific symposium in his honor. The symposium was held August 30, 2008 in Berkeley.

  5. 1975 Ride Quality Symposium

    DOT National Transportation Integrated Search

    1975-11-01

    A compilation is presented of papers reported at the 1975 Ride Quality Symposium held in Williamsburg, Virginia, August 11-12, 1975. The symposium, jointly sponsored by NASA and the United States Department of Transportation, was held to provide a fo...

  6. Beneficial Modifications of the Marine Environment. A Symposium Held March 11, 1968, Washington, D.C.

    ERIC Educational Resources Information Center

    National Academy of Sciences - National Research Council, Washington, DC.

    This volume contains papers presented at a symposium on beneficial modifications of the marine environment held in March, 1968. Included are four papers and accompanying discussions. One paper discusses the reason that the presence or absence of ice on the sea can influence the formation of climate and looks into the following two questions: (1)…

  7. Proceedings of the Third Spaceborne Imaging Radar Symposium

    NASA Technical Reports Server (NTRS)

    1993-01-01

    This publication contains summaries of the papers presented at the Third Spaceborne Imaging Radar Symposium held at the Jet Propulsion Laboratory (JPL), California Institute of Technology, in Pasadena, California, on 18-21 Jan. 1993. The purpose of the symposium was to present an overview of recent developments in the different scientific and technological fields related to spaceborne imaging radars and to present future international plans. This symposium is the third in a series of 'Spaceborne Imaging Radar' symposia held at JPL. The first symposium was held in Jan. 1983 and the second in 1986.

  8. Rail vehicle crashworthiness symposium

    DOT National Transportation Integrated Search

    1998-03-01

    This document contains the proceedings of the Rail Vehicle Crashworthiness Symposium held at the Volpe Center in Cambridge, Massachusetts on June 24, 25, and 26, 1996. These proceedings have been developed from a transcript of the symposium and the m...

  9. The Annual Department of Defense Procurement Research Symposium (5th), held 17-19 Nov 76, Monterey, California.

    DTIC Science & Technology

    1976-11-01

    Federal Procurement Policy Mr. Fred Bunke - Assistant Commissioner for Procurement, General Services Administration 5:00 - 6:00 p.m. No host cocktail party...Research Specialist General Services Administration -3- 71 Symposium Agenda 8:30 - 10:15 a.m. Concurrent Session II (cont’d.) WORKING GROUP E... Services Administration . From 1950 - 1960, Mr. Bunke held various supply and procurement billets at sea and ashore as a Navy Supply Corps Officer. From

  10. Histamine 50-skin-prick test: a tool to diagnose histamine intolerance.

    PubMed

    Kofler, Lukas; Ulmer, Hanno; Kofler, Heinz

    2011-01-01

    Background. Histamine intolerance results from an imbalance between histamine intake and degradation. In healthy persons, dietary histamine can be sufficiently metabolized by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity. Diamine oxidase (DAO) is the key enzyme in degradation. Histamine elicits a wide range of effects. Histamine intolerance displays symptoms, such as rhinitis, headache, gastrointestinal symptoms, palpitations, urticaria and pruritus. Objective. Diagnosis of histamine intolerance until now is based on case history; neither a validated questionnaire nor a routine test is available. It was the aim of this trial to evaluate the usefullness of a prick-test for the diagnosis of histamine intolerance. Methods. Prick-testing with 1% histamine solution and wheal size-measurement to assess the relation between the wheal in prick-test, read after 20 to 50 minutes, as sign of slowed histamine degradation as well as history and symptoms of histamine intolerance. Results. Besides a pretest with 17 patients with HIT we investigated 156 persons (81 with HIT, 75 controls): 64 out of 81 with histamine intolerance(HIT), but only 14 out of 75 persons from the control-group presented with a histamine wheal ≥3 mm after 50 minutes (P < .0001). Conclusion and Clinical Relevance. Histamine-50 skin-prickt-test offers a simple tool with relevance.

  11. Histamine 50-Skin-Prick Test: A Tool to Diagnose Histamine Intolerance

    PubMed Central

    Kofler, Lukas; Ulmer, Hanno; Kofler, Heinz

    2011-01-01

    Background. Histamine intolerance results from an imbalance between histamine intake and degradation. In healthy persons, dietary histamine can be sufficiently metabolized by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity. Diamine oxidase (DAO) is the key enzyme in degradation. Histamine elicits a wide range of effects. Histamine intolerance displays symptoms, such as rhinitis, headache, gastrointestinal symptoms, palpitations, urticaria and pruritus. Objective. Diagnosis of histamine intolerance until now is based on case history; neither a validated questionnaire nor a routine test is available. It was the aim of this trial to evaluate the usefullness of a prick-test for the diagnosis of histamine intolerance. Methods. Prick-testing with 1% histamine solution and wheal size-measurement to assess the relation between the wheal in prick-test, read after 20 to 50 minutes, as sign of slowed histamine degradation as well as history and symptoms of histamine intolerance. Results. Besides a pretest with 17 patients with HIT we investigated 156 persons (81 with HIT, 75 controls): 64 out of 81 with histamine intolerance(HIT), but only 14 out of 75 persons from the control-group presented with a histamine wheal ≥3 mm after 50 minutes (P < .0001). Conclusion and Clinical Relevance. Histamine-50 skin-prickt-test offers a simple tool with relevance. PMID:23724226

  12. Symposium Promotes Technological Literacy through STEM

    ERIC Educational Resources Information Center

    Havice, Bill; Marshall, Jerry

    2009-01-01

    This article describes a symposium which promotes technological literacy through science, technology, engineering, and mathematics (STEM). The three-day symposium titled, "The Anderson, Oconee, Pickens Symposium on Teaching and Learning STEM Standards for the 21st Century," was held August 4-6, 2008 at the Tri-County Technical College…

  13. Innovative Tuberculosis Symposium held during Cuba Salud 2015.

    PubMed

    Chapman, Helena J; Armas Pérez, Luisa

    2016-12-01

    The fourth Tuberculosis (TB) Symposium, held during the Cuba Salud 2015 International Convention, highlighted advancements in research on TB and Mycobacterium tuberculosis (Mtb) by interdisciplinary teams from academic and federal institutions in Cuba, Colombia, Mexico, and the Dominican Republic. Delegates focused on the targets presented in the World Health Organization End TB Strategy for 2016-2035 and elaborated on four primary themes: 1) attention to vulnerable populations such as immunocompromised individuals, health care workers, and residents of long-term institutions such as prisons and nursing homes; 2) identification of active and latent TB cases through contact investigations; 3) spread and control of drug-resistant Mtb strains; and 4) advancements in the development of novel vaccines or "booster" immunizations. This international TB forum served as a platform for experts in diverse disciplines in these Latin American countries to discuss challenges faced by TB research and control programs, proposing novel research initiatives and promoting collaborative teamwork strategies for TB elimination. In solidarity, collaborative efforts in TB control require identification of symptomatic individuals, rapid diagnostic testing for TB, drug susceptibility assays on Mtb strains, and management that provide universal and gratuitous access to directly observed short-course therapy. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. 32nd Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Walker, S. W. (Compiler); Boesiger, Edward A. (Compiler)

    1998-01-01

    The proceedings of the 32nd Aerospace Mechanism Symposium are reported. NASA John F. Kennedy Space Center (KSC) hosted the symposium that was held at the Hilton Oceanfront Hotel in Cocoa Beach, Florida on May 13-15, 1998. The symposium was cosponsored by Lockheed Martin Missiles and Space and the Aerospace Mechanisms Symposium Committee. During these days, 28 papers were presented. Topics included robotics, deployment mechanisms, bearing, actuators, scanners, boom and antenna release, and test equipment.

  15. The Eighth International Symposium On Radiative Transfer

    NASA Astrophysics Data System (ADS)

    Lemonnier, Denis; Webb, Brent W.; Mengüç, M. Pınar

    2017-08-01

    This Special Issue of The Journal of Quantitative Spectroscopy and Radiative Transfer is based on the papers selected from RAD-16, the Eighth International Symposium on Radiative Transfer, which was held June 2016, in Cappadocia, Turkey. This Symposium is a follow-up of the seven previous meetings held in Kuşadası in 1995, 1997, and 2013; Antalya in 2001 and 2010; Istanbul in 2004; and Bodrum in 2007, all in Turkey. The Symposium was another enjoyable opportunity for the international radiation transfer community to assemble in a comfortable setting to present and discuss the state-of-the-art in research and application.

  16. Birch symposium proceedings

    Treesearch

    W.T. Doolittle; P.E. Bruns

    1969-01-01

    This symposium on yellow and paper birch is the third in a series of meetings devoted to discussion of our fine hardwood timber species. The first meeting, held at Carbondale, Illinois, in 1966, dealt with black walnut. The second, held at Houghton, Michigan, in 1968, dealt with sugar maple. The purpose of this third meeting is to bring together our present knowledge...

  17. 41st Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Boesiger, Edward A. (Editor)

    2012-01-01

    The proceedings of the 41st Aerospace Mechanisms Symposium are reported. JPL hosted the conference, which was held in Pasadena Hilton, Pasadena, California on May 16-18, 2012. Lockheed Martin Space Systems cosponsored the symposium. Technology areas covered include gimbals and positioning mechanisms, components such as hinges and motors, CubeSats, tribology, and Mars Science Laboratory mechanisms.

  18. Multidisciplinary Perspectives on Musicality: The Seashore Symposium.

    ERIC Educational Resources Information Center

    Coffman, Don D.

    1999-01-01

    Contains the published proceedings of "Multidisciplinary Perspectives on Musicality: The Seashore Symposium," held at the University of Iowa on October 16-18, 1997. Provides an overview of the symposium, identifying speakers' contributions to particular themes, and includes abstracts from 35 speakers. (CMK)

  19. PREFACE: 4th International Symposium on Instrumentation Science and Technology (ISIST'2006)

    NASA Astrophysics Data System (ADS)

    Jiubin, Tan

    2006-10-01

    On behalf of the International Program Committee of ISIST'2006 and the symposium coordinators, I would like to thank all the participants for their presence at the 4th International Symposium on Instrumentation Science and Technology (ISIST'2006), a platform for scientists, researchers and experts from different parts of the world to present their achievements and to exchange their views on ways and means to further develop modern instrumentation science and technology. In the present information age, instrumentation science and technology is playing a more and more important role, not only in the acquisition and conversion of information at the very beginning of the information transformation chain, but also in the transfer, manipulation and utilization of information. It provides an analysis and test means for bioengineering, medical engineering, life science, environmental engineering and micro/nanometer technology, and integrates these disciplines to form new subdivisions of their own. The major subject of the symposium is crossover and fusion between instrumentation science and technology and other sciences and technologies. ISIST'2006 received more than 800 full papers from 12 countries and regions, from which 300 papers were finally selected by the international program committee for inclusion in the proceedings of ISIST'2006, published in 2 volumes. The major topics include instrumentation basic theory and methodology, sensors and conversion technology, signal and image processing, instruments and systems, laser and optical fiber instrumentation, advanced optical instrumentation, optoelectronics instrumentation, MEMS, nanotechnology and instrumentation, biomedical and environmental instrumentation, automatic test and control. The International Symposium on Instrumentation Science and Technology (ISIST) is sponsored by ICMI, NSFC, CSM, and CIS, and organized by ICMI, HIT and IC-CSM, and held every two years. The 1st symposium was held in LuoYang, China in

  20. Proceedings of the 5th Symposium on applied surface analysis

    NASA Astrophysics Data System (ADS)

    Grant, J. T.

    1984-04-01

    The 5th Symposium on Applied Surface Analysis was held at the University of Dayton, 8-10 June 1983. This Symposium was held to meet a need, namely to show the transition between basic surface science research and applications of this research to areas of Department of Defense interest. Areas receiving special attention at this Symposium were chemical bonding and reactions at metal-semiconductors interfaces, surface analysis and the tribological processes of ion implanted materials, microbeam analysis and laser ionization of sputtered neutrals. Other topics discussed included adsorption, adhesion, corrosion, wear and thin films. Approximately 110 scientists active in the field of surface analysis participated in the Symposium. Four scientists presented invited papers at the Symposium. There were 29 contributed presentations. The proceedings of the Symposium are being published in a special issue of the journal, Applications of Surface Science, by North-Holland Publishing Company.

  1. 35th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Boesiger, Edward A. (Compiler); Doty, Laura W. (Technical Monitor)

    2001-01-01

    The proceedings of the 35th Aerospace Mechanisms Symposium are reported. Ames Research Center hosted the conference, which was held at the Four Points Sheraton, Sunnyvale, California, on May 9-11, 2001. The symposium was sponsored by the Mechanisms Education Association. Technology areas covered included bearings and tribology; pointing, solar array, and deployment mechanisms; and other mechanisms for spacecraft and large space structures.

  2. 33rd Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Boesiger, Edward A. (Compiler); Litty, Edward C. (Compiler); Sevilla, Donald R. (Compiler)

    1999-01-01

    The proceedings of the 33rd Aerospace Mechanisms Symposium are reported. JPL hosted the conference, which was held at the Pasadena Conference and Exhibition Center, Pasadena, California, on May 19-21, 1999. Lockheed Martin Missiles and Space cosponsored the symposium. Technology areas covered include bearings and tribology; pointing, solar array and deployment mechanisms; orbiter/space station; and other mechanisms for spacecraft.

  3. 30th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Bradley, Obie H., Jr. (Compiler); Rogers, John F. (Compiler)

    1996-01-01

    The proceedings of the 30th Aerospace Mechanisms Symposium are reported. NASA Langley Research Center hosted the proceedings held at the Radisson Hotel in Hampton, Virginia on May 15-17, 1996, and Lockheed Martin Missiles and Space Company, Inc. co-sponsored the symposium. Technological areas covered include bearings and tribology; pointing, solar array, and deployment mechanisms; orbiter/space station; and other mechanisms for spacecraft.

  4. Productivity and Employment: The 1988 International Symposium.

    ERIC Educational Resources Information Center

    Brand, Horst

    1988-01-01

    The author summarizes the International Productivity Symposium, "Productivity and Employment," held in Washington, D.C., in April 1988. This symposium dealt with such topics as (1) preparing for a changing economy, (2) employment effects of productivity growth, (3) worker participation in decisions about work processes and organization,…

  5. The 21st Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    1987-01-01

    During the symposium technical topics addressed included deployable structures, electromagnetic devices, tribology, actuators, latching devices, positioning mechanisms, robotic manipulators, and automated mechanisms synthesis. A summary of the 20th Aerospace Mechanisms Symposium panel discussions is included as an appendix. However, panel discussions on robotics for space and large space structures which were held are not presented herein.

  6. Summary of the forest recreation symposium

    Treesearch

    Northeastern Forest Experiment Station

    1972-01-01

    Those who attended the Forest Recreation Symposium held 12-14 Octoher 1971 at Syracuse, New York, heard 26 papers about various aspects of forest recreation. Those papers have already been printed, in Proceedings made available at the Symposium, and also available upon request from the Northeastern Forest Experiment Station, 6816 Market Street, Upper Darby, Pa. 19082...

  7. Synapses as therapeutic targets for autism spectrum disorders: an international symposium held in pavia on july 4th, 2014.

    PubMed

    Curatolo, Paolo; Ben-Ari, Yehezkel; Bozzi, Yuri; Catania, Maria Vincenza; D'Angelo, Egidio; Mapelli, Lisa; Oberman, Lindsay M; Rosenmund, Christian; Cherubini, Enrico

    2014-01-01

    New progresses into the molecular and cellular mechanisms of autism spectrum disorders (ASDs) have been discussed in 1 day international symposium held in Pavia (Italy) on July 4th, 2014 entitled "synapses as therapeutic targets for autism spectrum disorders" (satellite of the FENS Forum for Neuroscience, Milan, 2014). In particular, world experts in the field have highlighted how animal models of ASDs have greatly advanced our understanding of the molecular pathways involved in synaptic dysfunction leading sometimes to "synaptic clinical trials" in children.

  8. Overview (this manuscript is an overview of an ASTM symposium. The authors, John Sebroski and Mark Mason, of the overview were the co-chairs of the symposium and co-editors of the manuscripts submitted for ASTM peer review and subsequent publication in the technical proceedings for the symposium)

    EPA Science Inventory

    The Symposium on Developing Consensus Standards for Measuring Chemical Emissions from Spray Polyurethane Foam (SPF) Insulation was held on April 30th and May 1, 2015. Sponsored by ASTM Committee D22 on Air Quality, the symposium was held in Anaheim, CA, in conjunction with the st...

  9. Growth and histamine formation of Morganella morganii in determining the safety and quality of inoculated and uninoculated bluefish (Pomatomus saltatrix).

    PubMed

    Lorca, T A; Gingerich, T M; Pierson, M D; Flick, G J; Hackney, C R; Sumner, S S

    2001-12-01

    The objective of this study was to determine the effect of normal microflora and Morganella morganii on histamine formation and olfactory acceptability in raw bluefish under controlled storage conditions. Fillets inoculated with and without M. morganii were stored at 5, 10, and 15 degrees C for 7 days. Microbial isolates from surface swabs were identified and screened for histidine decarboxylase activity. Olfactory acceptance was performed by an informal sensory panel. Histamine levels were quantified using high-performance liquid chromatography and fluorescence detection. While olfactory acceptance decreased, histamine concentration and bacterial counts increased. Storage temperature had a significant effect on histamine levels, bacterial counts, and olfactory acceptance of the bluefish. Inoculation with M. morganii had a positive significant effect on histamine formation for bluefish held at 10 and 15 degrees C (P < 0.0001). The results of the study will serve in supporting U.S. Food and Drug Administration (FDA) regulations regarding guidance and hazard levels of histamine in fresh bluefish.

  10. The histamine content of oriental foods.

    PubMed

    Chin, K W; Garriga, M M; Metcalfe, D D

    1989-05-01

    Several of the symptoms of scombroid poisoning (i.e. histamine toxicity) resemble those observed in people suffering from Chinese restaurant syndrome. Therefore, the histamine content of representative Chinese cuisine, which included 31 common dishes, 12 condiments and 12 basic ingredients from several sources, was measured using a sensitive and specific radioenzymatic assay. A further enzymatic procedure involving diamine oxidase was used to verify that the substance measured was histamine. A total of 184 assays were performed on 57 samples in the study. High levels of histamine were found in the cheeses, which were used as positive controls (863.6 micrograms histamine/g blue cheese and 107.4 micrograms histamine/g Parmesan cheese), and in some common condiments, including tamari (2392.2 micrograms histamine/g sample) and one brand of soy sauce (220.4 micrograms histamine/g sample). The histamine content of four condiments and three common dishes was over 10 micrograms histamine/g sample, while four condiments and 16 common dishes contained less than 1 microgram histamine/g sample. Calculations involving representative amounts of food that can be consumed at a typical oriental meal suggest that, in some cases, histamine intake may approach toxic levels. The results are discussed with regard to the possible role of histamine in reactions associated with restaurant meals.

  11. 1999 Flight Mechanics Symposium

    NASA Technical Reports Server (NTRS)

    Lynch, John P. (Editor)

    1999-01-01

    This conference publication includes papers and abstracts presented at the Flight Mechanics Symposium held on May 18-20, 1999. Sponsored by the Guidance, Navigation and Control Center of Goddard Space Flight Center, this symposium featured technical papers on a wide range of issues related to orbit-attitude prediction, determination, and control; attitude sensor calibration; attitude determination error analysis; attitude dynamics; and orbit decay and maneuver strategy. Government, industry, and the academic community participated in the preparation and presentation of these papers.

  12. Second Symposium on Water-in-Fuel Emulsions in Combustion

    DOT National Transportation Integrated Search

    1979-08-01

    This volume contains the proceedings of the second symposium on water-in-fuel emulsions held at the DOT Transportation Systems Center September 12 and 13, 1978. This symposium, sponsored by the DOT's U.S. Coast Guard and Research and Special Programs...

  13. Review of Waste Management Symposium 2007, Tucson, AZ, USA

    DOE PAGES

    Luna, Robert E.; Yoshimura, R. H.

    2007-03-01

    The Waste Management Symposium 2007 is the most recent in a long series that has been held at Tucson, Arizona. The meeting has become extremely popular as a venue for technical exchange, marketing, and networking involving upward of 1800 persons involved with various aspects of radioactive waste management. However, in a break with tradition, the symposium organizers reported that next year’s Waste Management Symposium would be held at the Phoenix, AZ convention center. Additionally, most of the WM07 sessions dealt with the technical and institutional issues relating to the resolution of waste disposal and processing challenges, including a number ofmore » sessions dealing with related transport activities.« less

  14. Proceedings of the fifth annual forest inventory and analysis symposium

    Treesearch

    Ronald E. McRoberts; Gregory A. Reams; Paul C. Van Deusen; William H., eds. McWilliams

    2005-01-01

    The Fifth Annual Forest Inventory and Analysis Symposium was held in New Orleans, Louisiana, the second consecutive year at this location. Given the positive response to the 2002 symposium in New Orleans, we decided to return in 2003. Each year of this symposium series the range of presentations has increased; 2003 was no exception, with several presentations related...

  15. Histamine and motivation

    PubMed Central

    Torrealba, Fernando; Riveros, Maria E.; Contreras, Marco; Valdes, Jose L.

    2012-01-01

    Brain histamine may affect a variety of different behavioral and physiological functions; however, its role in promoting wakefulness has overshadowed its other important functions. Here, we review evidence indicating that brain histamine plays a central role in motivation and emphasize its differential involvement in the appetitive and consummatory phases of motivated behaviors. We discuss the inputs that control histaminergic neurons of the tuberomamillary nucleus (TMN) of the hypothalamus, which determine the distinct role of these neurons in appetitive behavior, sleep/wake cycles, and food anticipatory responses. Moreover, we review evidence supporting the dysfunction of histaminergic neurons and the cortical input of histamine in regulating specific forms of decreased motivation (apathy). In addition, we discuss the relationship between the histamine system and drug addiction in the context of motivation. PMID:22783171

  16. Conserving biodiversity on native rangelands: Symposium proceedings

    Treesearch

    Daniel W. Uresk; Greg L. Schenbeck; James T. O' Rourke

    1997-01-01

    These proceedings are the result of a symposium, "Conserving biodiversity on native rangelands" held on August 17, 1995 in Fort Robinson State Park, NE. The purpose of this symposium was to provide a forum to discuss how elements of rangeland biodiversity are being conserved today. We asked, "How resilient and sustainable are rangeland systems to the...

  17. The 1988 Get Away Special Experimenter's Symposium

    NASA Technical Reports Server (NTRS)

    Thomas, Lawrence R. (Editor); Mosier, Frances L. (Editor)

    1988-01-01

    The Get Away Special (GAS) Experimenter's Symposium was held to provide a formal opportunity for GAS experimenters to share the results of their projects. The focus of this symposium is on payloads that have been flown on shuttle missions and on GAS payloads that will be flown in the future. Experiment design and payload integration issues are also examined.

  18. An Introduction to the Third International Symposium on Career Development and Public Policy

    ERIC Educational Resources Information Center

    McCowan, Colin

    2006-01-01

    This article presents the highlights of the Third International Symposium on Career Development and Public Policy, which was held at the Manly Pacific Hotel in Sydney, Australia from April 21-24, 2006. This symposium built on those held in Ottawa and Vancouver in 1999 and 2001 respectively and the Organisation for Economic Co-operation and…

  19. PROCEEDINGS: THE 1992 GREENHOUSE GAS EMISSIONS AND MITIGATION RESEARCH SYMPOSIUM

    EPA Science Inventory

    The report documents the 1992 Greenhouse Gas Emissions and Mitigation Research Symposium held in Washington, DC, August 18-20, 1992. The symposium provided a forum for exchange of technical information on global change emissions and potential mitigation technologies. The primary ...

  20. 2001 Flight Mechanics Symposium

    NASA Technical Reports Server (NTRS)

    Lynch, John P. (Editor)

    2001-01-01

    This conference publication includes papers and abstracts presented at the Flight Mechanics Symposium held on June 19-21, 2001. Sponsored by the Guidance, Navigation and Control Center of Goddard Space Flight Center, this symposium featured technical papers on a wide range of issues related to attitude/orbit determination, prediction and control; attitude simulation; attitude sensor calibration; theoretical foundation of attitude computation; dynamics model improvements; autonomous navigation; constellation design and formation flying; estimation theory and computational techniques; Earth environment mission analysis and design; and, spacecraft re-entry mission design and operations.

  1. Report on the Symposium “Molecular Mechanisms Involved in Neurodegeneration”

    PubMed Central

    Pentón-Rol, Giselle; Cervantes-Llanos, Majel

    2018-01-01

    The prevalence of neurodegenerative diseases is currently a major concern in public health because of the lack of neuroprotective and neuroregenerative drugs. The symposium on Molecular Mechanisms Involved in Neurodegeneration held in Varadero, Cuba, updated the participants on the basic mechanisms of neurodegeneration, on the different approaches for drug discovery, and on early research results on therapeutic approaches for the treatment of neurodegenerative diseases. Alzheimer’s disease and in silico research were covered by many of the presentations in the symposium, under the umbrella of the “State of the Art of Non-clinical Models for Neurodegenerative Diseases” International Congress, held from 20 to 24 June 2017. This paper summarizes the highlights of the symposium. PMID:29346273

  2. The 1975 Ride Quality Symposium

    NASA Technical Reports Server (NTRS)

    1975-01-01

    A compilation is presented of papers reported at the 1975 Ride Quality Symposium held in Williamsburg, Virginia, August 11-12, 1975. The symposium, jointly sponsored by NASA and the United States Department of Transportation, was held to provide a forum for determining the current state of the art relative to the technology base of ride quality information applicable to current and proposed transportation systems. Emphasis focused on passenger reactions to ride environment and on implications of these reactions to the design and operation of air, land, and water transportation systems acceptable to the traveling public. Papers are grouped in the following five categories: needs and uses for ride quality technology, vehicle environments and dynamics, investigative approaches and testing procedures, experimental ride quality studies, and ride quality modeling and criteria.

  3. Laser-induced damage in optical materials: sixteenth ASTM symposium.

    PubMed

    Bennett, H E; Guenther, A H; Milam, D; Newnam, B E

    1987-03-01

    The Sixteenth Annual Symposium on Optical Materials for High Power Lasers (Boulder Damage Symposium) was held at the National Bureau of Standards in Boulder, CO, 15-17 Oct. 1984. The Symposium was held under the auspices of ASTM Committee F-1, Subcommittee on Laser Standards, with the joint sponsorship of NBS, the Defense Advanced Research Project Agency, the Department of Energy, the Office of Naval Research, and the Air Force Office of Scientific Research. Approximately 180 scientists attended the Symposium, including representatives from England, France, The Netherlands, Scotland, and West Germany. The Symposium was divided into sessions concerning Materials and Measurements, Mirrors and Surfaces, Thin Films, and Fundamental Mechanisms. As in previous years, the emphasis of the papers presented at the Symposium was directed toward new frontiers and new developments. Particular emphasis was given to materials for high-power apparatus. The wavelength range of prime interest was from 10.6,microm to the UV region. Highlights included surface characterization, thin-film-substrate boundaries, and advances in fundamental laser-matter threshold interactions and mechanisms. Harold E. Bennett of the U.S. Naval Weapons Center, Arthur H. Guenther of the U.S. Air Force Weapons Laboratory, David Milam of the Lawrence Livermore National Laboratory, and Brian E. Newnam of the Los Alamos National Laboratory were cochairmen of the Symposium.

  4. First International Symposium on Strain Gauge Balances. Pt. 1

    NASA Technical Reports Server (NTRS)

    Tripp, John S. (Editor); Tcheng, Ping (Editor)

    1999-01-01

    The first International Symposium on Strain Gauge Balances was sponsored and held at NASA Langley Research Center during October 22-25, 1996. The symposium provided an open international forum for presentation, discussion, and exchange of technical information among wind tunnel test technique specialists and strain gauge balance designers. The Symposium also served to initiate organized professional activities among the participating and relevant international technical communities. Over 130 delegates from 15 countries were in attendance. The program opened with a panel discussion, followed by technical paper sessions, and guided tours of the National Transonic Facility (NTF) wind tunnel, a local commercial balance fabrication facility, and the LaRC balance calibration laboratory. The opening panel discussion addressed "Future Trends in Balance Development and Applications." Forty-six technical papers were presented in 11 technical sessions covering the following areas: calibration, automatic calibration, data reduction, facility reports, design, accuracy and uncertainty analysis, strain gauges, instrumentation, balance design, thermal effects, finite element analysis, applications, and special balances. At the conclusion of the Symposium, a steering committee representing most of the nations and several U.S. organizations attending the Symposium was established to initiate planning for a second international balance symposium, to be held in 1999 in the UK.

  5. First International Symposium on Strain Gauge Balances. Part 2

    NASA Technical Reports Server (NTRS)

    Tripp, John S (Editor); Tcheng, Ping (Editor)

    1999-01-01

    The first International Symposium on Strain Gauge Balances was sponsored and held at NASA Langley Research Center during October 22-25, 1996. The symposium provided an open international forum for presentation, discussion, and exchange of technical information among wind tunnel test technique specialists and strain gauge balance designers. The Symposium also served to initiate organized professional activities among the participating and relevant international technical communities. Over 130 delegates from 15 countries were in attendance. The program opened with a panel discussion, followed by technical paper sessions, and guided tours of the National Transonic Facility (NTF) wind tunnel, a local commercial balance fabrication facility, and the LaRC balance calibration laboratory. The opening panel discussion addressed "Future Trends in Balance Development and Applications." Forty-six technical papers were presented in 11 technical sessions covering the following areas: calibration, automatic calibration, data reduction, facility reports, design, accuracy and uncertainty analysis, strain gauges, instrumentation, balance design, thermal effects, finite element analysis, applications, and special balances. At the conclusion of the Symposium, a steering committee representing most of the nations and several U.S. organizations attending the Symposium was established to initiate planning for a second international balance symposium, to be held in 1999 in the UK.

  6. Trees for Reclamation Symposium Proceedings

    Treesearch

    Northeastern Forest Experiment Station

    1980-01-01

    A collection of 30 papers presented at the symposium on trees for reclamation in the Eastern United States held October 27-29, 1980, Lexington, Kentucky, and sponsored by the USDA Forest Service and Interstate Mining Compact Commission.

  7. 2016 AMS Mario J. Molina Symposium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Renyi

    A named symposium to honor Dr. Mario J. Molina was held 10–14 January 2016, as part of the 96th American Meteorological Society (AMS) Annual Meeting in New Orleans, Louisiana. Dr. Molina first demonstrated that industrially produced chlorofluorocarbons (CFCs) decompose in the stratosphere and release chlorine atoms, leading to catalytic ozone destruction. His research in stratospheric chemistry was instrumental to the establishment of the 1987 United Nations Montreal Protocol to ban ozone-depleting substances worldwide. Dr. Molina’s contributions to preserving the planet Earth not only save the atmospheric ozone layer, but also protect the climate by reducing the emissions of greenhouse gases.more » He was awarded the 1995 Nobel Prize in Chemistry for his pioneering research in understanding the stratospheric ozone loss mechanism. In 2013, President Barack Obama announced Dr. Molina as a recipient of the Presidential Medal of Freedom. The 2016 AMS Molina Symposium honored Dr. Molina’s distinguished contributions to research related to atmospheric chemistry. The symposium contained an integrated theme related to atmospheric chemistry, climate, and policy. Dr. Molina delivered a keynote speech at the Symposium. The conference included invited keynote speeches and invited and contributed oral and poster sessions, and a banquet was held on Tuesday January 12, 2016. The symposium covered all aspects of atmospheric chemistry, with topics including (1) Stratospheric chemistry, (2) Tropospheric chemistry, (3) Aerosol nucleation, growth, and transformation, (4) Aerosol properties, (5) Megacity air pollution, and (6) Atmospheric chemistry laboratory, field, and modeling studies. This DOE project supported 14 scientists, including graduate students, post docs, junior research scientists, and non-tenured assistant professors to attend this symposium.« less

  8. STATIONARY COMBUSTION NOX CONTROL: A SUMMARY OF THE 1991 SYMPOSIUM

    EPA Science Inventory

    The 1991 Symposium on Stationary Combustion NOX Control was held March 25-28,1991 in Washington, DC. The sixth meeting in a biennial series, the Symposium was cosponsored by the Electric Power Research Institute (EPRI) and the U.S. Environmental Protection Agency (EPA). Approxima...

  9. Fluorometric determination of histamine in cheese.

    PubMed

    Chambers, T L; Staruszkiewicz, W F

    1978-09-01

    Thirty-one samples of cheese obtained from retail outlets were analyzed for histamine, using an official AOAC fluorometric method. The types of cheese analyzed and the ranges of histamine found were: colby, 0.3--2.8; camembert, 0.4--4.2; cheddar, 1.2--5.8; gouda, 1.3--2.4; provolone, 2.0--23.5; roquefort, 1.0--16.8; mozzarella 1.6--5.0; and swiss, 0.4--250 mg histamine/100 g. Ten of the 12 samples of swiss cheese contained less than 16 mg histamine/100 g. The remaining 2 samples which contained 116 and 250 mg histamine/100 g were judged organoleptically to be of poor quality. An investigation of one processing facility showed that the production of histamine in swiss cheese may have been a result of a hydrogen peroxide/low temperature treatment of the milk supply. Recovery of histamine added to methanol extracts of cheese ranged from 93 to 105%. Histamine content was confirmed by high pressure liquid chromatographic analysis of the methanol extracts.

  10. Plant-Incorporated Protectants Data Symposium

    EPA Pesticide Factsheets

    EPA held a public symposium on data that support registration of plant incorporated protectants (PIPs). It provided firsthand information on the scope of the scientific review process regarding the safety of PIPs and on the pesticide registration process.

  11. [Outbreak due to butterfish consumption: keriorrhea and histamine poisoning].

    PubMed

    Fariñas Cabrero, Maria Azucena; Berbel Hernández, Clara; Allué Tango, Marta; Díez Hillera, Margarita; Herrero Marcos, Juan Antonio

    2015-01-01

    The consumption of butterfish is spreading in our country; if appropriate standards of conservation and preparation of this type of food are not met may cause poisoning. The objective is to describe an outbreak of histamine poisoning and double cerous esters after consumption butterfish. A descriptive study of the double intoxication at a banquet held in July 2013 in Valladolid. It was studied by filling a specific survey, by phone or by the medical centers who treated the guests. The database and subsequent descriptive statistical analyzes were performed with Microsoft Excel Professional Plus 2010 program. Of the 27 cases reported in 24 we obtained information on symptoms. The attack rate was 22.5 %, with a clinical picture in which predominant diarrhea (75%), headache (46%), abdominal pain (38%) and sweating (38%), highlighting its specificity itching/burning of mouth (29%). Four patients had orange and oily stools (keriorrhea). The average time from the start of dinner to onset of symptoms was 119 minutes. The mean duration of symptoms was 14 hours. Analytical served fish showed histamine levels above 2,000 mg / kg. A double poisoning (histamine and cerous esters) was produced by consumption of butterfish. The picture was mild and self-limiting. You need to know this type of poison to properly handle avoiding unnecessary tests, and to notify the health authority for investigation and subsequent adoption of appropriate measures.

  12. Laser induced damage in optical materials: twelfth ASTM symposium.

    PubMed

    Bennett, H E; Glass, A J; Guenther, A H; Newnam, B

    1981-09-01

    The twelfth annual Symposium on Optical Materials for High Power Lasers (Boulder Damage Symposium) was held at the National Bureau of Standards in Boulder, Colorado, 30 Sept.-l Oct., 1980. The symposium was held under the auspices of ASTM Committee F-l, Subcommittee on Laser Standards, with the joint sponsorship of NBS, the Defense Advanced Research Projects Agency, the Department of Energy, the Office of Naval Research, and the Air Force Office of Scientific research. Over 150 scientists attended the symposium, including representatives of the United Kingdom, France, Japan, and West Germany. The symposium was divided into sessions concerning materials and measurements, mirrors and surfaces, thin films, and finally fundamental mechanisms. As in previous years, the emphasis of the papers presented at the symposium was directed toward new frontiers and new developments. Particular emphasis was given to materials for high power systems. The wavelength range of prime interest was from 10.6 microm to the UV region. Highlights included surface characterization, thin film-substrate boundaries, and advances in fundamental laser-matter threshold interactions and mechanisms. The scaling of damage thresholds with pulse duration, focal area, and wavelength was discussed in detail. Harold E. Bennett of the Naval Weapons Center, Alexander J. Glass of the Lawrence Livermore National Laboratory, Arthur H. Guenther of the Air Force Weapons Laboratory, and Brian E. Newnam of the Los Alamos National Laboratory were cochairmen of the symposium. The thirteenth annual symposium is scheduled for 17-18 Nov. 1981 at the National Bureau of Standards, Boulder, Colorado.

  13. Comparative gut physiology symposium: The microbe-gut-brain axis

    USDA-ARS?s Scientific Manuscript database

    The Comparative Gut Physiology Symposium titled “The Microbe-Gut-Brain Axis” was held at the Joint Annual Meeting of the American Society of Animal Science and the American Dairy Science Association on Thursday, July 21, 2016, in Salt Lake City Utah. The goal of the symposium was to present basic r...

  14. Highlights of the second ISCB Student Council Symposium in Africa, 2017.

    PubMed

    Rafael, Candice N; Ashano, Efejiro; Moosa, Yumna; Shome, Sayane; DeBlasio, Dan

    2017-01-01

    Student Council Symposiums (SCSs) have been found to be very useful for students and young researchers. This is especially true given that the events are held directly before large international conferences, giving attendees a chance to gain exposure and have a warm up to the social nuances involved in attending such a meeting. This was the second SCS held in Africa in conjunction with the International Society for Computational Biology (ISCB) and the African Society for Bioinformatics and Computational Biology's (ASBCB) biennial meeting. This symposium was organised by students within the society inside Africa and was held on the 10 th of October 2017 in Entebbe, Uganda.

  15. GLOBAL CHANGE RESEARCH NEWS #18: SYMPOSIUM SESSION ON "GLOBAL ATMOSPHERIC CHANGE"

    EPA Science Inventory

    A session on "Understanding and Managing Effects of Global Atmospheric Change" will be held at the Fifth Symposium of the U.S. EPA National Health and Environmental Effects Research Laboratory. The Symposium topic is "Indicators in Health and Ecological Risk Assessment." The s...

  16. Physiology and Endocrinology Symposium. Factors controlling puberty in beef heifers

    USDA-ARS?s Scientific Manuscript database

    The Physiology and Endocrinology Symposium on “Factors controlling puberty in beef heifers” was held at the joint annual meeting of the American Dairy Science Association and the American Society of Animal Science in New Orleans, Louisiana, USA, July 10 to 14, 2011. The objective of the symposium w...

  17. Aeration Zone Symposium

    NASA Astrophysics Data System (ADS)

    Merkel, B.

    The International Symposium on Recent Investigations in the Zone of Aeration (RIZA) was organized by the Institute for Hydrogeology and Hydrochemistry of the Technical University of Munich and held October 1-5, 1984, in the lecture halls of the Grosshadern Klinik in Munich, Federal Republic of Germany (FRG). P. Udluft, B. Merkel, and K.-H. Prüsl, all of the university, were responsible for the organization of the symposium, which was under the patronage of K.-E. Quentin. There were over 200 participants from 22 different countries, among them Australia, Canada, China, India, and the United States. The topics of the symposium were the physical, chemical, and microbiological processes in the unsaturated zone, the region between the surface and the groundwater level. Here a number of complex processes occur that on the one hand are of natural origin and on the other hand are influenced by human activities in a number of ways.

  18. Precooking as a Control for Histamine Formation during the Processing of Tuna: An Industrial Process Validation.

    PubMed

    Adams, Farzana; Nolte, Fred; Colton, James; De Beer, John; Weddig, Lisa

    2018-02-23

    An experiment to validate the precooking of tuna as a control for histamine formation was carried out at a commercial tuna factory in Fiji. Albacore tuna ( Thunnus alalunga) were brought on board long-line catcher vessels alive, immediately chilled but never frozen, and delivered to an on-shore facility within 3 to 13 days. These fish were then allowed to spoil at 25 to 30°C for 21 to 25 h to induce high levels of histamine (>50 ppm), as a simulation of "worst-case" postharvest conditions, and subsequently frozen. These spoiled fish later were thawed normally and then precooked at a commercial tuna processing facility to a target maximum core temperature of 60°C. These tuna were then held at ambient temperatures of 19 to 37°C for up to 30 h, and samples were collected every 6 h for histamine analysis. After precooking, no further histamine formation was observed for 12 to 18 h, indicating that a conservative minimum core temperature of 60°C pauses subsequent histamine formation for 12 to 18 h. Using the maximum core temperature of 60°C provided a challenge study to validate a recommended minimum core temperature of 60°C, and 12 to 18 h was sufficient to convert precooked tuna into frozen loins or canned tuna. This industrial-scale process validation study provides support at a high confidence level for the preventive histamine control associated with precooking. This study was conducted with tuna deliberately allowed to spoil to induce high concentrations of histamine and histamine-forming capacity and to fail standard organoleptic evaluations, and the critical limits for precooking were validated. Thus, these limits can be used in a hazard analysis critical control point plan in which precooking is identified as a critical control point.

  19. 77 FR 4544 - CPSC Symposium on Phthalates Screening and Testing Methods

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-30

    ... Screening and Testing Methods AGENCY: Consumer Product Safety Commission. ACTION: Notice. SUMMARY: The... symposium on phthalates screening and testing methods. The symposium will be held at the CPSC's National... submit comments, identified by Docket No. CPSC-2012-0008, by any of the following methods: Electronic...

  20. Meeting Report: International Symposium on the Genetics of Aging and Life History II

    PubMed Central

    Lee, Seung‐Jae V.; Nam, Hong Gil

    2015-01-01

    The second International Symposium on the Genetics of Aging and Life History was held at the campus of Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Korea, from May 14 to 16, 2014. Many leading scientists in the field of aging research from all over the world contributed to the symposium by attending and presenting their recent work and thoughts. The aim of the symposium was to stimulate international collaborations and interactions among scientists who work on the biology of aging. In the symposium, the most recent and exciting work on aging research was presented, covering a wide range of topics, including the genetics of aging, age‐associated diseases, and cellular senescence. The work was conducted in various organisms, including C. elegans, mice, plants, and humans. Topics covered in the symposium stimulated discussion of novel directions for future research on aging. The meeting ended with a commitment for the third International Symposium on the Genetics of Aging and Life History, which will be held in 2016. PMID:26115541

  1. Meeting Report: International Symposium on the Genetics of Aging and Life History II.

    PubMed

    Artan, Murat; Hwang, Ara B; Lee, Seung V; Nam, Hong Gil

    2015-06-01

    The second International Symposium on the Genetics of Aging and Life History was held at the campus of Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Korea, from May 14 to 16, 2014. Many leading scientists in the field of aging research from all over the world contributed to the symposium by attending and presenting their recent work and thoughts. The aim of the symposium was to stimulate international collaborations and interactions among scientists who work on the biology of aging. In the symposium, the most recent and exciting work on aging research was presented, covering a wide range of topics, including the genetics of aging, age-associated diseases, and cellular senescence. The work was conducted in various organisms, includingC. elegans, mice, plants, and humans. Topics covered in the symposium stimulated discussion of novel directions for future research on aging. The meeting ended with a commitment for the third International Symposium on the Genetics of Aging and Life History, which will be held in 2016.

  2. Histamine in cereal dusts

    PubMed Central

    Nicholls, P. J.

    1970-01-01

    Nicholls, P. J. (1970).Brit. J. industr. Med.,27, 179-180. Histamine in cereal dusts. It has been found that workers exposed to cereal grain dusts may experience acute mild respiratory distress. An attempt has been made to explain this observation by examining the pharmacological activity of aqueous extracts of several cereal dusts from the holds of cargo ships. Histamine, but no other active agent, was found in the samples. It is unlikely that the concentration of histamine in these dusts is sufficient to cause respiratory distress in dockers unloading cereal grain cargoes. PMID:5428638

  3. In vitro study of histamine and histamine receptor ligands influence on the adhesion of purified human eosinophils to endothelium.

    PubMed

    Grosicki, Marek; Wójcik, Tomasz; Chlopicki, Stefan; Kieć-Kononowicz, Katarzyna

    2016-04-15

    It is a well-known fact that histamine is involved in eosinophil-dependent inflammatory responses including cellular chemotaxis and migration. Nevertheless, the relative role of histamine receptors in the mechanisms of eosinophils adhesion to endothelial cells is not known. Therefore the aim of presented study was to examine the effect of selective histamine receptors ligands on eosinophils adhesion to endothelium. For that purpose the highly purified human eosinophils have been isolated from the peripheral blood. The viability and functional integrity of isolated eosinophils have been validated in several tests. Histamine as well as 4-methylhistamine (selective H4 agonist) in concentration-dependent manner significantly increased number of eosinophils that adhere to endothelium. Among the selective histamine receptors antagonist or H1 inverse agonist only JNJ7777120 (histamine H4 antagonist) and thioperamide (dual histamine H3/H4 antagonist) had direct effect on eosinophils adhesion to endothelial cells. Antagonists of H1 (diphenhydramine, mepyramine) H2 (ranitidine and famotidine) and H3 (pitolisant) histamine receptors were ineffective. To the best of our knowledge, this is the first study to demonstrate that histamine receptor H4 plays a dominant role in histamine-induced eosinophils adhesion to endothelium. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Laser induced damage in optical materials: eleventh ASTM symposium.

    PubMed

    Bennett, H E; Glass, A J; Guenther, A H; Newnam, B

    1980-07-15

    The eleventh Symposium on Optical Materials for High-Power Lasers (Boulder Damage Symposium) was held at the National Bureau of Standards in Boulder, Colorado, 30-31 October 1979. The symposium was held under the auspices of ASTM Committee F-1, Subcommittee on Laser Standards, with the joint sponsorship of NBS, the Defense Advanced Research Projects Agency, the Department of Energy, and the Office of Naval Research. About 150 scientists attended the symposium, including representatives of the United Kingdom, France, Canada, Japan, West Germany, and Denmark. The symposium was divided into sessions concerning transparent optical materials and the measurement of their properties, mirrors and surfaces, thin film characteristics, thin film damage, considerations for high-power systems, and finally theory and breakdown. As in previous years, the emphasis of the papers presented at the symposium was directed toward new frontiers and new developments. Particular emphasis was given to materials for high-power apparatus. The wavelength range of prime interest was from 10.6 microm to the UV region. Highlights included surface characterization, thin film-substrate boundaries, and advances in fundamental laser-matter threshold interactions and mechanisms. The scaling of damage thresholds with pulse duration, focal area, and wavelength was discussed in detail. Harold E. Bennett of the Naval Weapons Center, Alexander J. Glass of the Lawrence Livermore Laboratory, Arthur H. Guenther of the Air Force Weapons Laboratory, and Brian E. Newnam of the Los Alamos Scientific Laboratory were cochairpersons. The twelfth annual symposium is scheduled for 30 September-1 October 1980 at the National Bureau of Standards, Boulder, Colorado.

  5. ANTI HISTAMINIC ACTIVITY OF CISSUS QUADRAGULARIS

    PubMed Central

    Begum, V. Hazeena; Sadique, J.

    1999-01-01

    Anti histaminic activity of cissus quadrangularis stem powder was carried out determining the histamine activity and histamine content in carrageenin induced rat paw swelling model and formalin induced peritonitis respectively. The crude powder at the dose of 100mg/1QQ00 gm exerted reduction to the maximum of 44% in the early hisamine phase swelling. Further it significantly reduced the histamine content in the peritoneal fluid. For comparison standard steroidal drug hydrocortisone and avil were used. PMID:22556903

  6. Anti histaminic activity of cissus quadragularis.

    PubMed

    Begum, V H; Sadique, J

    1999-01-01

    Anti histaminic activity of cissus quadrangularis stem powder was carried out determining the histamine activity and histamine content in carrageenin induced rat paw swelling model and formalin induced peritonitis respectively. The crude powder at the dose of 100mg/1QQ00 gm exerted reduction to the maximum of 44% in the early hisamine phase swelling. Further it significantly reduced the histamine content in the peritoneal fluid. For comparison standard steroidal drug hydrocortisone and avil were used.

  7. Welcome to the sudden oak death third science symposium

    Treesearch

    Susan J. Frankel

    2008-01-01

    On behalf of the United States Department of Agriculture (USDA)-Forest Service, Pacific Southwest Research Station and the California Oak Mortality Task Force, it is my pleasure to welcome you to the Sudden Oak Death Third Science Symposium. Looking back at the first sudden oak death science symposium held in Monterey in December 2002, it is amazing to see how far we...

  8. Natural Areas--Needs and Opportunities, 1970 Symposium Proceedings, Northwest Scientific Association.

    ERIC Educational Resources Information Center

    Dittrich, William J., Ed.; Trappe, James M., Ed.

    Proceedings of a symposium held at the Northwest Scientific Association Forty-Third Annual Meeting, Salem, Oregon, March, 1970, are presented. The symposium indicated that mutual understanding by educators, scientists, land managers, and politicians must be developed on the definition of naturalness, present and future use and management of…

  9. Progress In Electromagnetics Research Symposium (PIERS)

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The third Progress In Electromagnetics Research Symposium (PIERS) was held 12-16 Jul. 1993, at the Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California. More than 800 presentations were made, and those abstracts are included in this publication.

  10. Advances in the understanding of dairy and cheese flavors: Symposium Introduction

    USDA-ARS?s Scientific Manuscript database

    A symposium titled “Advances in the Understanding of Dairy and Cheese Flavors” was held in September 2013 at the American Chemical Society’s 246th National Meeting in Indianapolis, IN. The symposium, which was sponsored by the Division of Agricultural and Food Chemistry, was to discuss the state of...

  11. Ecosystem disturbance and wildlife conservation in western grasslands - A symposium proceedings

    Treesearch

    Deborah M. Finch

    1996-01-01

    This publication is the result of a half-day symposium, "Ecology, management, and sustainability of western grassland ecosystems" held at The Wildlife Society's First Annual Technical Conference, September 22-26, 1994 in Albuquerque, NM. The purpose of the symposium was to review and synthesize information about the structure, function, and...

  12. Advances in berry research: the sixth biennial berry health benefits symposium

    USDA-ARS?s Scientific Manuscript database

    Studies to advance the potential health benefits of berries continue to increase as was evident at the sixth biennial meeting of the Berry Health Benefits Symposium (BHBS). The two and a half-day symposium was held on October 13-15, 2015, in Madison, Wisconsin, United States. The 2015 BHBS feature...

  13. System analysis in forest resources: proceedings of the 2003 symposium.

    Treesearch

    Michael Bevers; Tara M. Barrett

    2005-01-01

    The 2003 symposium of systems analysis in forest resources brought together researchers and practitioners who apply methods of optimization, simulation, management science, and systems analysis to forestry problems. This was the 10th symposium in the series, with previous conferences held in 1975, 1985, 1988, 1991, 1993, 1994, 1997, 2000, and 2002. The forty-two papers...

  14. In Vivo Histamine Optical Nanosensors

    PubMed Central

    Cash, Kevin J.; Clark, Heather A.

    2012-01-01

    In this communication we discuss the development of ionophore based nanosensors for the detection and monitoring of histamine levels in vivo. This approach is based on the use of an amine-reactive, broad spectrum ionophore which is capable of recognizing and binding to histamine. We pair this ionophore with our already established nanosensor platform, and demonstrate in vitro and in vivo monitoring of histamine levels. This approach enables capturing rapid kinetics of histamine after injection, which are more difficult to measure with standard approaches such as blood sampling, especially on small research models. The coupling together of in vivo nanosensors with ionophores such as nonactin provide a way to generate nanosensors for novel targets without the difficult process of designing and synthesizing novel ionophores. PMID:23112690

  15. In vivo histamine optical nanosensors.

    PubMed

    Cash, Kevin J; Clark, Heather A

    2012-01-01

    In this communication we discuss the development of ionophore based nanosensors for the detection and monitoring of histamine levels in vivo. This approach is based on the use of an amine-reactive, broad spectrum ionophore which is capable of recognizing and binding to histamine. We pair this ionophore with our already established nanosensor platform, and demonstrate in vitro and in vivo monitoring of histamine levels. This approach enables capturing rapid kinetics of histamine after injection, which are more difficult to measure with standard approaches such as blood sampling, especially on small research models. The coupling together of in vivo nanosensors with ionophores such as nonactin provide a way to generate nanosensors for novel targets without the difficult process of designing and synthesizing novel ionophores.

  16. Highlights from CPTAC Scientific Symposium | Office of Cancer Clinical Proteomics Research

    Cancer.gov

    Dear Colleagues and Friends, The first CPTAC Public Scientific Symposium was recently held on November 13, 2013 at the National Institutes of Health in Bethesda, MD. The symposium brought together a record number of registrants, 450 scientists, who shared and discussed novel biological discoveries, analytical methods, and translational approaches using CPTAC data.

  17. Proceedings of the Twelfth International Symposium on Space Terahertz Technology

    NASA Technical Reports Server (NTRS)

    Mehdi, Imran (Editor)

    2001-01-01

    The Twelfth International Symposium on Space Terahertz Technology was held February 14-16, 2001 in San Diego, California, USA. This symposium was jointly sponsored by the National Aeronautics and Space Administration (NASA) and the Jet Propulsion Laboratory, California Institute of Technology. The symposium featured sixty nine presentations covering a wide variety of technical topics relevant to Terahertz Technology. The presentations can be divided into five broad technology areas: Hot Electron Bolometers, superconductor insulator superconductor (SIS) technology, local oscillator (LO) technology, Antennas and Measurements, and Direct Detectors. The symposium provides scientists, engineers, and researchers working in the terahertz technology and science fields to engineers their work and exchange ideas with colleagues.

  18. The ninth international veterinary immunology symposium

    USDA-ARS?s Scientific Manuscript database

    This Introduction to the special issue of Veterinary Immunology and Immunopathology summarizes the Proceedings of the 9th International Veterinary Immunology Symposium (9th IVIS) held August, 2010, in Tokyo, Japan. Over 340 delegates from 30 countries discussed research progress analyzing the immune...

  19. Atlantic white cedar: ecology, restoration, and management: Proceedings of the Arlington Echo symposium

    Treesearch

    Philip Sheridan

    2005-01-01

    A symposium was held on the globally threatened and coastally restricted tree species, Atlantic white-cedar (Chamaecyparis thyoides (L) B.S.P.) at the Arlington Echo Outdoor Education Center, Millersville, MD, in June 2003. The theme of the symposium was “Uniting Forces for Action,” and participants in the symposium came from throughout the range of this species, from...

  20. Microgravity Fluid Management Symposium

    NASA Technical Reports Server (NTRS)

    1987-01-01

    The NASA Microgravity Fluid Management Symposium, held at the NASA Lewis Research Center, September 9 to 10, 1986, focused on future research in the microgravity fluid management field. The symposium allowed researchers and managers to review space applications that require fluid management technology, to present the current status of technology development, and to identify the technology developments required for future missions. The 19 papers covered three major categories: (1) fluid storage, acquisition, and transfer; (2) fluid management applications, i.e., space power and thermal management systems, and environmental control and life support systems; (3) project activities and insights including two descriptions of previous flight experiments and a summary of typical activities required during development of a shuttle flight experiment.

  1. The histamine content of dried flying fish products in Taiwan and the isolation of halotolerant histamine-forming bacteria.

    PubMed

    Kung, Hsien-Feng; Huang, Chun-Yung; Lin, Chia-Min; Liaw, Lon-Hsiu; Lee, Yi-Chen; Tsai, Yung-Hsiang

    2015-06-01

    Thirty dried flying fish products were purchased from fishing village stores in Taiwan and tested to detect the presence of histamine and histamine-forming bacteria. Except for histamine and cadaverine, the average content of various biogenic amines in the tested samples was less than 3.5 mg/100 g. Eight (26.6%) dried flying fish samples had histamine levels greater than the United States Food and Drug Administration guideline of 5 mg/100 g for scombroid fish and/or scombroid products, whereas four (13.3%) samples contained more than the hazard action level of 50 mg/100 g. One histamine-producing bacterial isolate was identified as Staphylococcus xylosus by 16S rDNA sequencing with polymerase chain reaction amplification. This isolate was capable of producing 507.8 ppm of histamine in trypticase soy broth supplemented with 1.0% l-histidine (TSBH). The S. xylosus isolate was a halotolerant bacterium that had a consistent ability to produce more than 300 ppm of histamine at 3% sodium chloride concentration in TSBH medium after 72 hours. Copyright © 2015. Published by Elsevier B.V.

  2. Laser induced damage in optical materials: tenth ASTM symposium.

    PubMed

    Glass, A J; Guenther, A H

    1979-07-01

    The tenth annual Symposium on Optical Materials for High Power Lasers (Boulder Damage Symposium) was held at the National Bureau of Standards in Boulder, Colorado, 12-14 September 1978. The symposium was held under the auspices of ASTM Committee F-1, Subcommittee on Laser Standards, with the joint sponsorship of NBS, the Defense Advanced Research Project Agency, the Department of Energy, and the Office of Naval Research. About 175 scientists attended, including representatives of the United Kingdom, France, Canada, Japan, West Germany, and the Soviet Union. The symposium was divided into sessions concerning the measurement of absorption characteristics, bulk material properties, mirrors and surfaces, thin film damage, coating materials and design, and breakdown phenomena. As in previous years, the emphasis of the papers presented was directed toward new frontiers and new developments. Particular emphasis was given to materials for use from 10.6 microm to the UV region. Highlights included surface characterization, thin film-substrate boundaries, and advances in fundamental laser-matter threshold interactions and mechanisms. The scaling of damage thresholds with pulse duration, focal area, and wavelength was also discussed. In commemoration of the tenth symposium in this series, a number of comprehensive review papers were presented to assess the state of the art in various facets of laser induced damage in optical materials. Alexander J. Glass of Lawrence Livermore Laboratory and Arthur H. Guenther of the Air Force Weapons Laboratory were co-chairpersons. The eleventh annual symposium is scheduled for 30-31 October 1979 at the National Bureau of Standards, Boulder, Colorado.

  3. Proceedings of the Army Symposium on Solid Mechanics. Advances in Solid Mechanics for Design and Analysis Held at Newport, Rhode Island on 1-3 October 1984.

    DTIC Science & Technology

    1984-10-01

    Proceedings of the Army Symposium on Solid Mechanics, 1984 - Advances in Solid Mechanics for Design and Analysis, held at Newport, Rhode Island, 1-3...aie not to he construed as an official Department of the Army position, unless so designated by othei * author/id documents. Menton of any trade names...Starting with the 1972 meeting, papers have been solicited from in-house and contract researchers and designers for the Navy, Air Force, and other

  4. Interagency Symposium on University Research in Transportation Noise (2nd) Held at North Carolina State University, Raleigh on June 5-7, 1974. Book of Proceedings, Volume 2

    DTIC Science & Technology

    1974-06-01

    RESEARCH IN TRANSPORTATION NOISE (2ND), HELD AT NORTH CAROLINA STATE UNIVERSITY, RALEIGH, ON JUNE 5-7, 1974 BOOK OF PROCEEDINGS, VOLUME II NORTH... Research in Transportation Noise, Vol. II ?. Recipient𔃻. Accession No. 5. Report Dire June 5-7, 1974 6. 7. Aurhor(s> 8. Performing...Interagency Symposium on University Research in Transportation Noise was to continue to focus attention on university research in basic and applied

  5. Smoking influences salivary histamine levels in periodontal disease.

    PubMed

    Bertl, K; Haririan, H; Laky, M; Matejka, M; Andrukhov, O; Rausch-Fan, X

    2012-05-01

    Histamine, a potent vasoactive amine, is increased in saliva of periodontitis patients. The present study aimed to further investigate the diagnostic potential of histamine for periodontal disease and assessed smoking, a major risk factor of periodontitis, as a possible influencing factor. Salivary and serum samples of 106 participants (60 periodontitis patients, 46 controls) were collected. Salivary histamine was determined by a commercially available ELISA kit, and serum C-reactive protein was measured by a routine laboratory test. Cigarettes per day and packyears were assessed as smoking exposure parameters. Statistically significantly increased levels of salivary histamine and serum C-reactive protein were detected between the patient and control group (P = 0.022 and P = 0.001). Salivary histamine levels were significantly higher in smoking compared with non-smoking patients (P < 0.001), and salivary histamine as well as serum C-reactive protein correlated significantly positively with smoking exposure parameters (P < 0.05). Smoking, an established and common risk factor of periodontitis, was assessed as a possible influencing factor for salivary histamine. Most interestingly, salivary histamine differed highly significantly between smoking and non-smoking periodontitis patients. Our results suggest a possible involvement of histamine in tobacco-exacerbated periodontal disease, but do not suggest salivary histamine as a reliable diagnostic marker for periodontitis. © 2011 John Wiley & Sons A/S.

  6. The Ninth National Space Symposium

    NASA Astrophysics Data System (ADS)

    Lipskin, Beth Ann; Patterson, Sara; Brescia, David A.; Burk, Donna; Flannery, Jack; St. John, Pat; Zimkas, Chuck

    Proceedings of the Ninth National Space Symposium held 13-16 April 1993 by the United States Space Foundation are presented. Presentations made at the symposium are included. Topics discussed include: Change, Challenge and Opportunity; Washington Insiders: National Space Policy and Budget Issues; Civil Space: a Vision for the Future; Space Power for an Expanded Vision; Unparalled Launch Vehicle Propulsion Capabilities; National Security Space Issues; Perspectives on the Air Force in Space; Future Technology: Space Propulsion, Earth Observation and International Cooperation; Achieving Efficient Space Transportation; the Future in Space Exploration; Kids, Parents and Teachers are into Space; and Public Congressional Forum on Space - International Space Issues.

  7. Proceedings of the sixth California oak symposium: today's challenges, tomorrow's opportunities

    Treesearch

    Adina Merenlender; Douglas McCreary; Kathryn L. Purcell

    2008-01-01

    The Sixth Oak Symposium provided a forum for current research and outstanding case studies on oak woodland science and sustainability in California. This symposium was the latest in a series of conferences on this subject held every 5 years since 1979. The proceedings from this conference series represent the most comprehensive source of scientific and management...

  8. PROCEEDINGS OF "THE LEAD REMEDIATION EFFECTIVENESS SYMPOSIUM"

    EPA Science Inventory

    A Symposium on Lead Remediation Effectiveness, sponsored by the US Environmental Protection Agency, was held at Coeur d'Alene, Idaho, USA from 22-25 May, 2000. International participants from various levels of government, educational institutions, industry, and community represen...

  9. CONTROL TECHNOLOGY: SUMMARY OF THE 1991 EPRI/EPA/DOE S02 CONTROL SYMPOSIUM

    EPA Science Inventory

    The 1991 SO2 Control Symposium was held December 3–6, 1991, in Washington, D.C. The symposium, jointly sponsored by the Electric Power Research Institute (EPRI), the U.S. Environmental Protection Agency (EPA), and the U.S. Department of Energy (DOE), focused attention...

  10. Final Report of the Bilingual Symposium: Building a Research Agenda. Volume 2.

    ERIC Educational Resources Information Center

    Center for Applied Linguistics, Arlington, VA.

    This is the second of a series of three volumes containing papers from a bilingual symposium held in 1975. Presentations and discussion at the symposium dealt primarily with suggestions for research which linguists should undertake to assist bilingual programs. This volume contains the following papers: "A Survey of Research in Syntax," by Arnold…

  11. Albizia lebbeck suppresses histamine signaling by the inhibition of histamine H1 receptor and histidine decarboxylase gene transcriptions.

    PubMed

    Nurul, Islam Mohammed; Mizuguchi, Hiroyuki; Shahriar, Masum; Venkatesh, Pichairajan; Maeyama, Kazutaka; Mukherjee, Pulok K; Hattori, Masashi; Choudhuri, Mohamed Sahabuddin Kabir; Takeda, Noriaki; Fukui, Hiroyuki

    2011-11-01

    Histamine plays major roles in allergic diseases and its action is mediated mainly by histamine H(1) receptor (H1R). We have demonstrated that histamine signaling-related H1R and histidine decarboxylase (HDC) genes are allergic diseases sensitive genes and their expression level affects severity of the allergic symptoms. Therefore, compounds that suppress histamine signaling should be promising candidates as anti-allergic drugs. Here, we investigated the effect of the extract from the bark of Albizia lebbeck (AL), one of the ingredients of Ayruvedic medicines, on H1R and HDC gene expression using toluene-2,4-diisocyanate (TDI) sensitized allergy model rats and HeLa cells expressing endogenous H1R. Administration of the AL extract significantly decreased the numbers of sneezing and nasal rubbing. Pretreatment with the AL extract suppressed TDI-induced H1R and HDC mRNA elevations as well as [(3)H]mepyramine binding, HDC activity, and histamine content in the nasal mucosa. AL extract also suppressed TDI-induced up-regulation of IL-4, IL-5, and IL-13 mRNA. In HeLa cells, AL extract suppressed phorbol-12-myristate-13-acetate- or histamine-induced up-regulation of H1R mRNA. Our data suggest that AL alleviated nasal symptoms by inhibiting histamine signaling in TDI-sensitized rats through suppression of H1R and HDC gene transcriptions. Suppression of Th2-cytokine signaling by AL also suggests that it could affect the histamine-cytokine network. Copyright © 2011 Elsevier B.V. All rights reserved.

  12. International Symposium on Halide Glasses (2nd) (Extended Abstracts).

    DTIC Science & Technology

    1983-08-05

    of these materials. It is hoped that the atmosphere of the 1st Symposium will be maintained at the 2nd Symposium. The meeting will be held in a...purification of HfF4 and ZrFo by sublimation in a hydrogen fluoride atmosphere and purification of individual components and glasses by reactive atmosphere ...Tregoat and G. Fonteneau, U. Rennes, Rennes, France Reactive atmosphere processing developed by Mort Robinson at Hughes Research Labs. for the

  13. PREFACE: The 8th China International NanoScience and Technology Symposium

    NASA Astrophysics Data System (ADS)

    Cong, Hailin

    2009-09-01

    The 8th China International NanoScience and Technology Symposium, Xiangtan (2009) - Nano-products Exposition, sponsored by Chinese Society of Miro-nanoTechnology and IEEE Nanotechnology Council, etc will be held on 23-27 October 2009 in Xiangtan, China. This symposium is held in order to promote the technology for the development of micro- and nano-scale, cross-scale integration, to share new micro/nano technologies, to exchange information and knowledge over all fields and promote the industrialization and development of nanotechnology. This is a leading professional and traditional conference with at least 400 participants every year. Famous experts, professors and government officials at home and abroad will give lectures during the symposium, which provides a good platform for delegates to discover the latest developments and dynamics of nanotechnology. Researchers, teachers and students in colleges, and technical personnel in the industrial community are welcome to contribute and actively participate in the symposium. In our last symposium held in 2008, over 600 participants from all over the world attended, and we received over 570 abstract and paper submissions for the proceedings published in different languages in famous professional journals. And this year, we have already received over 400 submissions. After strict peer review, 60 of them are published in this volume of Journal of Physics: Conference Series. We are confident that the event will be even more successful this year. Consequently, the organizing committee and proceedings editorial committee would like to thank our colleagues at the IOP Publishing, the invited speakers, our sponsors and all the delegates for their great contributions in this conference. Hailin Cong Vice Chair of the proceedings editorial committee

  14. The 26th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The proceedings of the 26th Aerospace Mechanisms Symposium, which was held at the Goddard Space Flight Center on May 13, 14, and 15, 1992 are reported. Technological areas covered include actuators, aerospace mechanism applications for ground support equipment, lubricants, latches, connectors and other mechanisms for large space structures.

  15. 7th Annual Symposium on Clinical and Pharmaceutical Solutions through Analysis.

    PubMed

    Zhang, Tianyi Tee; Wang, Li; Weng, Naidong; Dong, Kelly; Valaskovic, Gary; Lee, Mike

    2016-10-01

    7th Annual Symposium on Clinical & Pharmaceutical Solutions through Analysis, Renaissance Shanghai Pudong Hotel, Shanghai, China, 20-23 April 2016 The 7th Annual Shanghai Symposium on Innovative Approaches to Reduce Attrition and Predict Clinical Outcomes (CPSA Shanghai 2016) was held on 20-23 April 2016 in Renaissance Shanghai Pudong Hotel, Shanghai, China. The meeting was featured with highly interactive events including diversified symposia, round table discussions, workshops, poster sessions and conference awards. There were over 220 participants from more than ten countries, with 61 oral presentations and 29 posters presented. In addition, the meeting included one preconference workshop and three joint sessions held with bioanalytical experts from local communities.

  16. The Fifth Symposium on Numerical and Physical Aspects of Aerodynamic Flows

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This volume contains the papers presented at the Fifth Symposium on Numerical and Physical Aspects of Aerodynamic Flows, held at the California State University, Long Beach, from 13 to 15 January 1992. The symposium, like its immediate predecessors, considers the calculation of flows of relevance to aircraft, ships, and missiles with emphasis on the solution of two-dimensional unsteady and three-dimensional equations.

  17. Global perspectives on poisonous plants: The 9th International Symposium on Poisonous Plants

    USDA-ARS?s Scientific Manuscript database

    The 9th International Symposium on Poisonous Plants (ISOPP9) was held from 15th-21st July, 2013, at the Inner Mongolia Agricultural University in Hohhot, Inner Mongolia Autonomous Region of China. The Symposium consisted of three days of oral and poster presentations, followed by a tour of the Xilin...

  18. Stimulatory effects of histamine on migration of nasal fibroblasts.

    PubMed

    Hong, Sung-Moon; Park, Il-Ho; Um, Ji-Young; Shin, Jae-Min; Lee, Heung-Man

    2015-10-01

    Fibroblast migration is crucial for normal wound repair after sinonasal surgery. Histamine is known to be involved in wound healing by its effects on cell proliferation and migration. This study aimed to determine whether histamine affects the migration of nasal fibroblasts and to investigate the mechanism of action of histamine on nasal fibroblasts. Primary cultures of nasal fibroblasts were established from inferior turbinate samples. Fibroblast migration was evaluated with scratch assays. Cells were treated with histamine and/or histamine receptor-selective antagonists. U-73122 and pertussis toxin, which are selective inhibitors of the lower signaling pathway of H1R and H4R, were used to confirm the modulation of nasal fibroblast migration by histamine. Fibroblast cytoskeletal structures were visualized with immunocytochemistry. Histamine significantly stimulated the migration of nasal fibroblasts. Antagonists selective for HR1 and HR4 significantly reduced nasal fibroblast migration. In immunocytochemical staining, histamine treatment increased membrane ruffling and pyrilamine, diphenhydramine, fexofenadine, and JNJ7777120 decreased histamine-induced membrane ruffling. U-73122 and pertussis toxin also decreased histamine-induced migration of fibroblasts. Histamine maintains its stimulatory effects on fibroblast migration in the presence of mitomycin C, which blocks proliferation of cells. We showed that histamine stimulates fibroblast migration in nasal fibroblasts. This effect appeared to be mediated by HR1 and HR4. However, because fibroblast migration also can be involved in scaring and fibrosis, more research is necessary to determine the effects of antihistamine on wound healing after sinus surgery. © 2015 ARS-AAOA, LLC.

  19. Histamine poisoning (scombroid fish poisoning): an allergy-like intoxication.

    PubMed

    Taylor, S L; Stratton, J E; Nordlee, J A

    1989-01-01

    Histamine poisoning results from the consumption of foods, typically certain types of fish and cheeses, that contain unusually high levels of histamine. Spoiled fish of the families, Scombridae and Scomberesocidae (e.g. tuna, mackerel, bonito), are commonly implicated in incidents of histamine poisoning, which leads to the common usage of the term, "scombroid fish poisoning", to describe this illness. However, certain non-scombroid fish, most notably mahi-mahi, bluefish, and sardines, when spoiled are also commonly implicated in histamine poisoning. Also, on rare occasions, cheeses especially Swiss cheese, can be implicated in histamine poisoning. The symptoms of histamine poisoning generally resemble the symptoms encountered with IgE-mediated food allergies. The symptoms include nausea, vomiting, diarrhea, an oral burning sensation or peppery taste, hives, itching, red rash, and hypotension. The onset of the symptoms usually occurs within a few minutes after ingestion of the implicated food, and the duration of symptoms ranges from a few hours to 24 h. Antihistamines can be used effectively to treat this intoxication. Histamine is formed in foods by certain bacteria that are able to decarboxylate the amino acid, histidine. However, foods containing unusually high levels of histamine may not appear to be outwardly spoiled. Foods with histamine concentrations exceeding 50 mg per 100 g of food are generally considered to be hazardous. Histamine formation in fish can be prevented by proper handling and refrigerated storage while the control of histamine formation in cheese seems dependent on insuring that histamine-producing bacteria are not present in significant numbers in the raw milk.

  20. Triennial Reproduction Symposium: challenges and opportunities facing livestock reproduction in the 21st century.

    USDA-ARS?s Scientific Manuscript database

    The 2009 Triennial Reproduction Symposium was held immediately before the Joint Annual Meeting of the American Society of Animal Science, American Dairy Science Association, and Canadian Society of Animal Science in Montreal, Canada, in July 2009. The intent of the symposium was to identify major ch...

  1. TERATOLOGY SOCIETY 1998 PUBLIC AFFAIRS COMMITTEE SYMPOSIUM: THE NEW THALIDOMIDE ERA: DEALING WITH THE RISKS

    EPA Science Inventory

    The Teratology Society Public Affairs Committee Symposium was held on June 21, 1998, during the Society's annual meeting in San Diego, California. The symposium was organized and chaired by Dr. Carole Kimmel. The sysmposium was designed to consider the medical, social, and ethi...

  2. The 22nd Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    1988-01-01

    The proceedings of the symposium, which was held at the NASA Langley Research Center, on May 4 to 6, 1988, are reported. Technological areas covered include space lubrication, bearings, aerodynamic devices, spacecraft latches, deployment, positioning, and pointing. Devices for space station docking and manipulator and teleoperator mechanisms are also described.

  3. The 27th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Mancini, Ron (Compiler)

    1993-01-01

    The proceedings of the 27th Aerospace Mechanisms Symposium, which was held at ARC, Moffett Field, California, on 12-14 May 1993, are reported. Technological areas covered include the following: actuators, aerospace mechanism applications for ground support equipment, lubricants, latches, connectors, robotic mechanisms, and other mechanisms for large space structures.

  4. Women on Campus: 1970; A Symposium.

    ERIC Educational Resources Information Center

    Michigan Univ., Ann Arbor. Center for Continuing Education for Women.

    The symposium: Women on Campus, 1970, held at Michigan University on October 14, 1970, centered on 3 major topics: "Toward a New Psychology of Women"; "The Case of the Woman Graduate Student"; and "The University and Women." The papers that were presented concerning the first topic included: "Internal Barriers to…

  5. Degradation of Histamine by Lactobacillus plantarum Isolated from Miso Products.

    PubMed

    Kung, Hsien-Feng; Lee, Yi-Chen; Huang, Ya-Ling; Huang, Yu-Ru; Su, Yi-Cheng; Tsai, Yung-Hsiang

    2017-10-01

    Histamine is a toxic chemical and is the causative agent of food poisoning. This foodborne toxin may be degraded by the oxidative deamination activity of certain microorganisms. In this study, we isolated four histamine-degrading Lactobacillus plantarum bacteria from miso products. Among them, L. plantarum D-103 exhibited 100% degradation of histamine in de Man Rogosa Sharpe (MRS) broth containing 50 ppm of histamine after 24 h of incubation at 30°C. The optimal growth, histamine oxidase, and histamine-degrading activity of L. plantarum D-103 were observed in histamine MRS broth at pH 7.0, 3% NaCl, and 30°C. It also exhibited tolerance to broad ranges of pH (4 to 10) and salt concentrations (0 to 12%) in histamine MRS broth. Therefore, the histamine-degrading L. plantarum D-103 might be used as an additive culture to prevent histamine accumulation in miso products during fermentation.

  6. Activation of the canonical beta-catenin pathway by histamine.

    PubMed

    Diks, Sander H; Hardwick, James C; Diab, Remco M; van Santen, Marije M; Versteeg, Henri H; van Deventer, Sander J H; Richel, Dick J; Peppelenbosch, Maikel P

    2003-12-26

    Histamine signaling is a principal regulator in a variety of pathophysiological processes including inflammation, gastric acid secretion, neurotransmission, and tumor growth. We report that histamine stimulation causes transactivation of a T cell factor/beta-catenin-responsive construct in HeLa cells and in the SW-480 colon cell line, whereas histamine did not effect transactivation of a construct containing the mutated response construct FOP. On the protein level, histamine treatment increases phosphorylation of glycogen synthase kinase 3-beta in HeLa cells, murine macrophages, and DLD-1, HT-29, and SW-480 colon cell lines. Furthermore, histamine also decreases the phosphorylated beta-catenin content in HeLa cells and murine macrophages. Finally, pharmacological inhibitors of the histamine H1 receptor counteracted histamine-induced T cell factor/beta-catenin-responsive construct transactivation and the dephosphorylation of beta-catenin in HeLa cells and in macrophages. We conclude that the canonical beta-catenin pathway acts downstream of the histamine receptor H1 in a variety of cell types. The observation that inflammatory molecules, like histamine, activate the beta-catenin pathway may provide a molecular explanation for a possible link between inflammation and cancer.

  7. Brick & Click Libraries: An Academic Library Symposium (13th, Maryville, Missouri, November 1, 2013)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Johnson, Carolyn, Ed.; Park, Sarag G., Ed.

    2013-01-01

    Twenty-six scholarly papers and ten abstracts comprise the content of the thirteenth annual Brick and Click Libraries Symposium, held annually at Northwest Missouri State University in Maryville, Missouri. The proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of librarianship. The…

  8. PROCEEDINGS OF THE 1992 EPA/AWMA INTERNATIONAL SYMPOSIUM MEASUREMENT OF TOXIC AND RELATED AIR POLLUTANTS

    EPA Science Inventory

    The 1992 USEPA/AWMA International Symposium Measurement of Toxic and Related Air Pollutants was held in Durham, NC on May 4-9, 1992. his yearly symposium is sponsored by the Atmospheric Research and Exposure Assessment Laboratory and the Air & Waste Management Association. he tec...

  9. Symposium: A Beginning in the Humanities

    ERIC Educational Resources Information Center

    Brooks, Peter; Fry, Paul H.; Carnochan, W. B.; Culler, Jonathan; Lerer, Seth; Marshall, Donald G.; Johnson, Barbara; Steiner, Wendy; Haack, Susan; Nussbaum, Martha C.

    2002-01-01

    2001 marked Yale's 300th birthday. It seemed an opportunity for reflection on the evolution of the institution, and particularly on the vicissitudes of the humanities over those three centuries. This article presents essays which represent a selection from the symposium, "Beginning With the Humanities," held at the Whitney Humanities Center on…

  10. Symposium: Ionic and Respiratory Interaction in Aquatic Animals

    ERIC Educational Resources Information Center

    Physiologist, 1976

    1976-01-01

    Presented are eight abstracts of a symposium held in conjunction with the American Physiological Society (APS) and the American Society of Zoologists (ASZ). Fish gill structure and function, renal function, acid-base balance and ionic sensitivity are topics discussed. (EB)

  11. Symposium overview: alterations in cytokine receptors by xenobiotics.

    PubMed

    Cohen, M D; Schook, L B; Oppenheim, J J; Freed, B M; Rodgers, K E

    1999-04-01

    A symposium entitled Alterations in Cytokine Receptors by Xenobiotics was held at the 37th Annual Meeting of the Society of Toxicology (SOT) in Seattle, Washington. The symposium was sponsored by the Immunotoxicology Specialty Section of SOT and was designed to present information on the effect of several different classes of xenobiotics on various aspects of receptor function (i.e., post-receptor signal transduction of receptor expression), or the involvement of cytokine receptors in the action of the toxicant under consideration. This symposium brought together scientists in the area of receptor immunobiology whose expertise in receptor modulation encompassed those major signaling agents involved in the normal immune response, i.e., proinflammatory cytokines, chemokines, interleukins, and interferons. The following is a summary of each of the individual presentations.

  12. The Second International Symposium on Plant Cryopreservation

    USDA-ARS?s Scientific Manuscript database

    The Second International Symposium on Plant Cryopreservation was held in Fort Collins, Colorado, USA, from August 11-14, 2013, under the auspices of the International Society for Horticultural Science. The town of Fort Collins is home to the USDA-ARS, National Center for Genetic Resources Preservati...

  13. 2ND International Symposium on HIFU Therapy HIFU Seattle 2002

    DTIC Science & Technology

    2002-12-01

    Drug Delivery, and Sonodynamic Therapy. One can see from this topic coverage that the symposium was largely on HIFU (essentially the first five topics), yet also broad enough to cover most aspects of therapeutic ultrasound ....This book is a compilation of papers presented at the 2nd International Symposium on Therapeutic Ultrasound , held in Seattle, Washington, July 29...number of topic categories, viz., Clinical Studies, Laboratory Studies, Simulation and Monitoring, Dosimetry, Engineering, Lithotripsy, Ultrasound -Enhanced

  14. Effect of Different Cooking Methods on Histamine Levels in Selected Foods

    PubMed Central

    Chung, Bo Young; Park, Sook Young; Byun, Yun Sun; Son, Jee Hee; Choi, Yong Won; Cho, Yong Se

    2017-01-01

    Background Histamine in food is known to cause food poisoning and allergic reactions. We usually ingest histamine in cooked food, but there are few studies about the influence of cooking method on the histamine level. Objective The purpose of this study was to determine the influence of cooking methods on the concentration of histamine in foods. Methods The foods chosen were those kinds consumed frequently and cooked by grilling, boiling, and frying. The histamine level of the food was measured using enzyme-linked immunosorbent assay. Results Grilled seafood had higher histamine levels than raw or boiled seafood. For meat, grilling increased the histamine level, whereas boiling decreased it. For eggs, there was not much difference in histamine level according to cooking method. Fried vegetables had higher histamine levels than raw vegetables. And fermented foods didn't show much difference in histamine level after being boiled. Conclusion The histamine level in food has changed according to the cooking method used to prepare it. Frying and grilling increased histamine level in foods, whereas boiling had little influence or even decreased it. The boiling method might be helpful to control the effect of histamine in histamine-sensitive or susceptible patients, compared with frying and grilling. PMID:29200758

  15. STIP Symposium on Physical Interpretation of Solar/Interplanetary and Cometary Intervals

    NASA Technical Reports Server (NTRS)

    Wu, S. T.

    1987-01-01

    The study of travelling interplanetary phenomena has continued over a period of years. The STIP (Study of Travelling Interplanetary Phenomena) Symposium on Physical Interpretation of Solar/Interplanetary and Cometary Intervals was held in Huntsville, Alabama, on May 12-15, 1987, the first of these meetings to be held in the United States. The Symposium's objective was to coordinate and disseminate new science gained from the recent solar-terrestrial and cometary intervals which can be used to better understand the linkage of physical events to the Sun's vagaries (flares, coronal holes, eruptive prominences) from their initial detection to their consequence. Fifty-one presentations were made during the four-day period. Abstracts of these reports are included as Appendix A.

  16. Fifth International Symposium on Magnetic Suspension Technology

    NASA Technical Reports Server (NTRS)

    Groom, Nelson J. (Editor); Britcher, Colin P.

    2000-01-01

    In order to examine the state of technology of all areas of magnetic suspension and to review recent developments in sensors, controls, superconducting magnet technology, and design/implementation practices, the Fifth International Symposium on Magnetic Suspension Technology was held at the Radisson Hotel Santa Barbara, Santa Barbara, California, on December 1-3, 1999. The symposium included 18 sessions in which a total of 53 papers were presented. The technical sessions covered the areas of bearings, controls, modeling, electromagnetic launch, magnetic suspension in wind tunnels, applications flywheel energy storage, rotating machinery, vibration isolation, and maglev. A list of attendees is included in the document.

  17. Fourth International Symposium on Magnetic Suspension Technology

    NASA Technical Reports Server (NTRS)

    Groom, Nelson J. (Editor); Britcher, Colin P. (Editor)

    1998-01-01

    In order to examine the state of technology of all areas of magnetic suspension and to review recent developments in sensors, controls, superconducting magnet technology, and design/implementation practices, the Fourth International Symposium on Magnetic Suspension Technology was held at The Nagaragawa Convention Center in Gifu, Japan, on October 30 - November 1, 1997. The symposium included 13 sessions in which a total of 35 papers were presented. The technical sessions covered the areas of maglev, controls, high critical temperature (T(sub c)) superconductivity, bearings, magnetic suspension and balance systems (MSBS), levitation, modeling, and applications. A list of attendees is included in the document.

  18. Third International Symposium on Magnetic Suspension Technology

    NASA Technical Reports Server (NTRS)

    Groom, Nelson J. (Editor); Britcher, Colin P. (Editor)

    1996-01-01

    In order to examine the state of technology of all areas of magnetic suspension and to review recent developments in sensors, controls, superconducting magnet technology, and design/implementation practices, the Third International Symposium on Magnetic Suspension Technology was held at the Holiday Inn Capital Plaza in Tallahassee, Florida on 13-15 Dec. 1995. The symposium included 19 sessions in which a total of 55 papers were presented. The technical sessions covered the areas of bearings, superconductivity, vibration isolation, maglev, controls, space applications, general applications, bearing/actuator design, modeling, precision applications, electromagnetic launch and hypersonic maglev, applications of superconductivity, and sensors.

  19. A tale of two cedars – International symposium on western redcedar and yellow-cedar

    Treesearch

    Constance Harrington

    2010-01-01

    From May 24-28, 2010, an international symposium on western redcedar (Thuja plicata) and yellowcedar (Callitropsis nootkatensis [syn., Chamaecyparis nootkatensis]) was held at the University of Victoria on Vancouver Island in British Columbia, Canada. The symposium was entitled “A Tale of Two Cedars” and...

  20. Status Report on the "Wildfires and Invasive Plants in American Deserts" Symposium and Workshop

    USDA-ARS?s Scientific Manuscript database

    The “Wildfires and Invasive Plants in American Deserts” symposium and workshop, was held in Reno, Nevada on December 9-11, 2008. The purpose of this symposium was to synthesize the current understanding of the interactions of wildfire and invasive plants in the four U.S. deserts and the Colorado Pla...

  1. Histamine food poisonings: A systematic review and meta-analysis.

    PubMed

    Colombo, Fabio M; Cattaneo, Patrizia; Confalonieri, Enrica; Bernardi, Cristian

    2018-05-03

    The aim of this study was to assess the mean of histamine concentration in food poisoning. Systematic review and meta-analysis of reports published between 1959 and 2013. Main criteria for inclusion of studies were: all report types that present outbreaks of "histamine poisoning' or "scombroid syndrome" from food, including histamine content and type of food. Health status of people involved must be nonpathological. Fifty-five (55) reports were included, these studies reported 103 incidents. All pooled analyses were based on random effect model; histamine mean concentration in poisoning samples was 1107.21 mg/kg with confidence interval for the meta-mean of 422.62-2900.78 mg/kg; heterogeneity index (I2) was 100% (P < 0.0001); prediction interval was 24.12-50822.78 mg/kg. Fish involved in histamine poisoning was mainly tuna or Istiophoridae species. No clues of association between concomitant conditions (female sex, alcohol consumption, previous medication, and consumption of histamine releasing food) and histamine poisoning, were highlighted. This is the first systematic review and meta-analysis that analyzes all the available data on histamine poisoning outbreaks evaluating the histamine concentration in food involved. Histamine mean concentration in poisoning samples was fairly high. Our study suffers from some limitations, which are intrinsic of the studies included, for instance the lack of a complete anamnesis of each poisoning episode. Protocol registration: Methods were specified in advance and have been published as a protocol in PROSPERO database (18/07/2012 -CRD42012002566).

  2. Proceedings of the first international symposium on acid precipitation and the forest ecosystem

    Treesearch

    L.S. Dochinger; T.A. Seliga

    1976-01-01

    These Proceedings report on the results of The First International Symposium on Acid Precipitation and the Forest Ecosystem which was held at The Ohio State University, Columbus, Ohio, U.S.A., on May 12-15, 1975. The Symposium focused on four related topics: (1) atmospheric chemistry, transport and precipitation; and effects of acidic precipitation on (2) aquatic...

  3. The 13th Annual James L. Waters Symposium at Pittcon: Electron Spectroscopy for Chemical Analysis

    ERIC Educational Resources Information Center

    Baltrus, John P.

    2004-01-01

    The objective of the James L. Waters Annual Symposium is to recognize pioneers in the development of instrumentation by preserving the early history of the cooperation and important contributions of inventors, scientists, engineers, entrepreneurs, and marketing organizations. The symposium was held in Pittsburgh, United States in March 2002 to…

  4. Brick and Click Libraries: An Academic Library Symposium (12th, Maryville, Missouri, October 26, 2012)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Johnson, Carolyn, Ed.

    2012-01-01

    Twenty scholarly papers and fifteen abstracts comprise the content of the twelfth annual Brick and Click Libraries Symposium, held at Northwest Missouri State University in Maryville, Missouri. The peer-reviewed proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of librarianship.…

  5. 2006 Homeland Security Symposium and Exposition. Held in Arlington, VA on 29-31 March 2006

    DTIC Science & Technology

    2006-03-31

    Consequences , Vulnerabilities, and Threats) Prioritize Implement Protective Programs Measure Effectiveness 9March 2006 Major NIPP Theme: Sector Partnership... effect of exposure • Full understanding of the levels of exposure that mark the onset of miosis • Refined human operational exposure standard for GB...Untitled Document 2006 Homeland Security Symposium and Exposition.html[7/7/2016 11:38:26 AM] 2006 Homeland Security Symposium and Exposition

  6. The 58th Shock and Vibration Symposium, volume 1

    NASA Technical Reports Server (NTRS)

    Pilkey, Walter D. (Compiler); Pilkey, Barbara F. (Compiler)

    1987-01-01

    The proceedings of the 58th Shock and Vibration Symposium, held in Huntsville, Alabama, October 13 to 15, 1987 are given. Mechanical shock, dynamic analysis, space shuttle main engine vibration, isolation and damping, and analytical methods are discussed.

  7. International symposium on erosion and landscape evolution abstracts

    USDA-ARS?s Scientific Manuscript database

    This book contains all of the extended abstracts from the ASABE specialty conference, the International Symposium on Erosion and Landscape Evolution (ISELE), held September 18-21, 2011 at the Hilton Anchorage Hotel in Anchorage, Alaska. Three extended abstracts from the meeting keynote speakers as ...

  8. Triennial Growth Symposium: Dietary regulation of growth development

    USDA-ARS?s Scientific Manuscript database

    The 2010 Triennial Growth Symposium was held immediately before the Joint Annual Meeting of the American Dairy Science Association, Poultry Science Association, Asociación Mexicana de Producción Animal, Canadian Society of Animal Science, Western Section American Society of Animal Science, and Ameri...

  9. Histamine-induced vasodilatation in the human forearm vasculature

    PubMed Central

    Sandilands, Euan A; Crowe, Jane; Cuthbert, Hayley; Jenkins, Paul J; Johnston, Neil R; Eddleston, Michael; Bateman, D Nicholas; Webb, David J

    2013-01-01

    Aim To investigate the mechanism of action of intra-arterial histamine in the human forearm vasculature. Methods Three studies were conducted to assess changes in forearm blood flow (FBF) using venous occlusion plethysmography in response to intra-brachial histamine. First, the dose–response was investigated by assessing FBF throughout a dose-escalating histamine infusion. Next, histamine was infused at a constant dose to assess acute tolerance. Finally, a four way, double-blind, randomized, placebo-controlled crossover study was conducted to assess FBF response to histamine in the presence of H1- and H2-receptor antagonists. Flare and itch were assessed in all studies. Results Histamine caused a dose-dependent increase in FBF, greatest with the highest dose (30 nmol min−1) infused [mean (SEM) infused arm vs. control: 26.8 (5.3) vs. 2.6 ml min−1 100 ml−1; P < 0.0001]. Dose-dependent flare and itch were demonstrated. Acute tolerance was not observed, with an increased FBF persisting throughout the infusion period. H2-receptor antagonism significantly reduced FBF (mean (95% CI) difference from placebo at 30 nmol min−1 histamine: −11.9 ml min−1 100 ml−1 (−4.0, −19.8), P < 0.0001) and flare (mean (95% CI) difference from placebo: −403.7 cm2 (−231.4, 576.0), P < 0.0001). No reduction in FBF or flare was observed in response to the H1-receptor antagonist. Itch was unaffected by the treatments. Histamine did not stimulate vascular release of tissue plasminogen activator or von Willebrand factor. Conclusion Histamine causes dose-dependent vasodilatation, flare and itch in the human forearm. H2-receptors are important in this process. Our results support further exploration of combined H1- and H2-receptor antagonist therapy in acute allergic syndromes. PMID:23488545

  10. DOE Grant to organize "International Symposium on Opportunities in Underground Physics", Asilomar, CA, May 24-27, 2013

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Babu, Kaladi S.

    2015-03-16

    The International Symposium in Opportunities in Underground Physics (ISOUP) was held in Asilomar, CA during May 24-27, 2013. The Symposium brought together scientists from the US and abroad for an open discussion on science opportunities provided by the possibility of a new generation of large underground detectors associated with long baseline neutrino beams. The Symposium was highly successful. The main focus of the Symposium was the science goals that could be achieved by placing such a detector deep underground.

  11. REMEDIAL ACTION, TREATMENT AND DISPOSAL OF HAZARDOUS WASTE: PROCEEDINGS OF THE SIXTEENTH ANNUAL HAZARDOUS WASTE RESEARCH SYMPOSIUM

    EPA Science Inventory

    The Sixteenth Annual Research Symposium on Remedial Action, Treatment and Disposal of Hazardous Waste was held in Cincinnati, Ohio, April 3-5, 1990. he purpose of this Symposium was to present the latest significant research findings from ongoing and recently completed projects f...

  12. Scombroid poisoning--recapitulation on the role of histamine.

    PubMed

    Foo, L Y

    1977-05-25

    The histamine content and the total vagal stimulating activities in various fish samples involved in an outbreak of food poisoning were compared. There was a close correlation between the two levels and there was lack of potentiation between histamine and other non-active fractions. The role of histamine in scombroid poisoning is discussed in the light of these results.

  13. Science and stewardship to protect and sustain wilderness values: Eighth World Wilderness Congress symposium

    Treesearch

    Alan Watson; Janet Sproull; Liese Dean

    2007-01-01

    The Eighth World Wilderness Congress met in Anchorage, Alaska, in 2005. The symposium on science and stewardship to protect and sustain wilderness values was the largest of multiple symposia held in conjunction with the Congress. The papers contained in this proceedings were generated at this symposium, submitted by the author or authors for consideration for inclusion...

  14. The 1992 4th NASA SERC Symposium on VLSI Design

    NASA Technical Reports Server (NTRS)

    Whitaker, Sterling R.

    1992-01-01

    Papers from the fourth annual NASA Symposium on VLSI Design, co-sponsored by the IEEE, are presented. Each year this symposium is organized by the NASA Space Engineering Research Center (SERC) at the University of Idaho and is held in conjunction with a quarterly meeting of the NASA Data System Technology Working Group (DSTWG). One task of the DSTWG is to develop new electronic technologies that will meet next generation electronic data system needs. The symposium provides insights into developments in VLSI and digital systems which can be used to increase data systems performance. The NASA SERC is proud to offer, at its fourth symposium on VLSI design, presentations by an outstanding set of individuals from national laboratories, the electronics industry, and universities. These speakers share insights into next generation advances that will serve as a basis for future VLSI design.

  15. Social Research and Broadcasting. Proceedings of a Symposium.

    ERIC Educational Resources Information Center

    University of Southern California, Los Angeles. Annenberg School of Communications.

    A special symposium held at the University of Southern California examined an agenda for action, "Social Research on Broadcasting--Proposals for Further Development," which was commissioned by the British Broadcasting Company and written by Professor Elihu Katz of the Hebrew University of Jerusalem. Participants included communications and…

  16. Overcoming Malnutrition: Putting Federal Programs to Work. A Report on the First National WIC Symposium.

    ERIC Educational Resources Information Center

    Fleming, Virginia; And Others

    This report describes the proceedings of a symposium on the Special Supplemental Food Program for Women, Infants and Children (WIC) and the Commodity Supplemental Food Program (SFP), held in January, 1977. The symposium was intended to bring together a variety of individuals concerned with providing adequate nutrition and health care to low-income…

  17. Transonic Symposium: Theory, Application, and Experiment, volume 1, part 2

    NASA Technical Reports Server (NTRS)

    Foughner, Jerome T., Jr. (Compiler)

    1989-01-01

    In order to assess the state of the art in transonic flow disciplines and to glimpse at future directions, NASA-Langley held a Transonic Symposium. Emphasis was placed on steady, three dimensional external, transonic flow and its simulation, both numerically and experimentally. The symposium included technical sessions on wind tunnel and flight experiments; computational fluid dynamic applications; inviscid methods and grid generation; viscous methods and boundary layer stability; and wind tunnel techniques and wall interference. This, being volume 1, is unclassified.

  18. Cell phone data and travel behavior research: symposium summary report

    DOT National Transportation Integrated Search

    2014-07-01

    This report summarizes the key themes from a symposium held on February 12, 2014, to discuss opportunities and challenges using cellular location data for national travel behavior analysis. Participants discussed the availability of cellular data and...

  19. Eighteenth symposium on biotechnology for fuels and chemicals: Program and abstracts

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-12-31

    This volume provides the proceedings for the Eighteenth Symposium on Biotechnology for Fuels and Chemicals held May 5-9, 1996 in Gatlinburg, Tennessee. The proceedings contains abstracts for oral and poster presentations.

  20. Space Transportation Propulsion Technology Symposium. Volume 2: Symposium proceedings

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Space Transportation Propulsion Symposium was held to provide a forum for communication within the propulsion technology developer and user communities. Emphasis was placed on propulsion requirements and initiatives to support current, next generation, and future space transportation systems, with the primary objectives of discerning whether proposed designs truly meet future transportation needs and identifying possible technology gaps, overlaps, and other programmatic deficiencies. Key space transportation propulsion issues were addressed through four panels with government, industry, and academia membership. The panels focused on systems engineering and integration; development, manufacturing and certification; operational efficiency; and program development and cultural issues.

  1. Aircraft Piston Engine Exhaust Emission Symposium

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A 2-day symposium on the reduction of exhaust emissions from aircraft piston engines was held on September 14 and 15, 1976, at the Lewis Research Center in Cleveland, Ohio. Papers were presented by both government organizations and the general aviation industry on the status of government contracts, emission measurement problems, data reduction procedures, flight testing, and emission reduction techniques.

  2. The 29th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Schneider, William C. (Editor)

    1995-01-01

    The proceedings of the 29th Aerospace Mechanisms Symposium, which was hosted by NASA Johnson Space Center and held at the South Shore Harbour Conference Facility on May 17-19, 1995, are reported. Technological areas covered include actuators, aerospace mechanism applications for ground support equipment, lubricants, pointing mechanisms joints, bearings, release devices, booms, robotic mechanisms, and other mechanisms for spacecraft.

  3. The 28th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Rohn, Douglas A. (Compiler)

    1994-01-01

    The proceedings of the 28th Aerospace Mechanisms Symposium, which was hosted by the NASA Lewis Research Center and held at the Cleveland Marriott Society Center on May 18, 19, and 20, 1994, are reported. Technological areas covered include actuators, aerospace mechanism applications for ground support equipment, lubricants, pointing mechanisms joints, bearings, release devices, booms, robotic mechanisms, and other mechanisms for spacecraft.

  4. The Junior Science & Humanities Symposium: Management and Operations, 2003-2004. Theme--Atmosphere--The Other Ocean.

    ERIC Educational Resources Information Center

    Schlenker, Richard M.

    This document reviews the Pacific Region Junior Science and Humanities Symposium (PJSHS) program for 2003-2004 which is a 10-month, precollege student research program held in Japan. The theme is AtmosphereThe Other Ocean. The program includes a one-week symposium of student delegates who have completed research projects in the sciences or have…

  5. Report from the second international symposium on animal genomics for animal health: critical needs, challenges and potential solutions

    USDA-ARS?s Scientific Manuscript database

    The second International Symposium on Animal Genomics for Animal Health held in Paris, France 31 May-2 June, 2010, assembled more than 140 participants representing research organizations from 40 countries. The symposium included a roundtable discussion on critical needs, challenges and opportunitie...

  6. Report from the Second International Symposium on Animal Genomics for Animal Health: Critical Needs, Challenges and Potential Solutions

    USDA-ARS?s Scientific Manuscript database

    The second International Symposium on Animal Genomics for Animal Health held in Paris, France 31 May-2 June, 2010, assembled more than 140 participants representing research organizations from 40 countries. The symposium included a roundtable discussion on critical needs, challenges and opportunitie...

  7. Fenspiride inhibits histamine-induced responses in a lung epithelial cell line.

    PubMed

    Quartulli, F; Pinelli, E; Broué-Chabbert, A; Gossart, S; Girard, V; Pipy, B

    1998-05-08

    Using the human lung epithelial WI26VA4 cell line, we investigated the capacity of fenspiride, an anti-inflammatory drug with anti-bronchoconstrictor properties, to interfere with histamine-induced intracellular Ca2+ increase and eicosanoid formation. Histamine and a histamine H1 receptor agonist elicited a rapid and transient intracellular Ca2+ increase (0-60 s) in fluo 3-loaded WI26VA4 cells. This response was antagonized by the histamine H1 receptor antagonist, diphenhydramine, the histamine H2 receptor antagonist, cimetidine, having no effect. Fenspiride (10(-7)-10(-5) M) inhibited the histamine H1 receptor-induced Ca2+ increase. In addition, histamine induced a biphasic increase in arachidonic acid release. The initial rise (0-30 s), a rapid and transient arachidonic acid release, was responsible for the histamine-induced intracellular Ca2+ increase. In the second phase release (15-60 min), a sustained arachidonic acid release appeared to be associated with the formation of cyclooxygenase and lipoxygenase metabolites. Fenspiride (10(-5) M) abolished both phases of histamine-induced arachidonic acid release. These results suggest that anti-inflammatory and antibronchoconstrictor properties of fenspiride may result from the inhibition of these effects of histamine.

  8. Brick and Click Libraries: Proceedings of an Academic Libraries Symposium (7th, Maryville, Missouri, November 2, 2007)

    ERIC Educational Resources Information Center

    Ury, Connie Jo, Ed.; Baudino, Frank, Ed.; Park, Sarah G., Ed.

    2007-01-01

    Twenty-three scholarly papers and eleven abstracts reflect the content of the seventh "Brick and Click Libraries Symposium," held annually at Northwest Missouri State University in Maryville, Missouri. The proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of…

  9. Brick and Click Libraries: Proceedings of an Academic Library Symposium (9th, Maryville, Missouri, November 6, 2009)

    ERIC Educational Resources Information Center

    Ury, Connie Jo, Ed.; Baudino, Frank, Ed.; Park, Sarah G., Ed.

    2009-01-01

    Twenty-one scholarly papers and fourteen abstracts comprise the content of the ninth annual "Brick and Click Libraries Symposium," held annually at Northwest Missouri State University in Maryville, Missouri. The peer-reviewed proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future…

  10. The 2011 North American strawberry symposium: an introduction

    USDA-ARS?s Scientific Manuscript database

    The 2011 Symposium was held in conjunction with the 32nd North American Strawberry Growers Association (NASGA) Annual Conference on 8-11 Feb. 2011, at the Doubletree Hotel in Tampa, FL. The scientific program was conducted over two days and featured five sessions of oral and poster presentations sp...

  11. The 13th Tihany Symposium on Radiation Chemistry

    NASA Astrophysics Data System (ADS)

    Wojnárovits, László; Takács, Erzsébet

    2016-07-01

    The Symposium was held in Balatonalmádi, a beautiful city by the Lake Balaton, Hungary, between August 29 and September 3, 2015. This time - to meet the expectations of many colleagues and friends - a place close to the village Tihany was selected, where the first Tihany Symposium was organized in 1962. The participants beside the excellent lectures could also enjoy the panorama of the Lake from the rooms and from the terrace of Hotel Ramada. The number of participants was close to 170 from about 33 countries. The highest number of participants arrived from Poland (14), followed by France (11), Turkey (9) and China (9). The Symposium had 6-6 colleagues from Brazil, Israel, and Romania. Beside China, Asia was represented by a few scientists from the Republic of Korea, Malaysia, Thailand, Philippines and from Saudi Arabia.

  12. Fourth International Symposium on Long-Range Sound Propagation

    NASA Technical Reports Server (NTRS)

    Willshire, William L., Jr. (Compiler)

    1990-01-01

    Long range sound propagation is an aspect of many acoustical problems ranging from en route aircraft noise to the acoustic detection of aircraft. Over the past decade, the University of Mississippi and the Open University of England, together with a third institution, have held a symposium approx. every 2 years so that experts in the field of long range propagation could exchange information on current research, identify areas needing additional work, and coordinate activities as much as possible. The Fourth International Symposium on Long Range Sound Propagation was jointly sponsored by the University of Mississippi, the Open University of England, and NASA. Papers were given in the following areas: ground effects on propagation; infrasound propagation; and meteorological effects on sound propagation. A compilation of the presentations made at the symposium is presented along with a list of attendees, and the agenda.

  13. Highlights from the Second International Symposium on HPV infection in head and neck cancer.

    PubMed

    Wiegand, Susanne; Wichmann, G; Golusinski, W; Leemans, C R; Klussmann, J P; Dietz, A

    2018-06-01

    The Second International Symposium on HPV Infection in Head and Neck Cancer was held on 3rd-4th November 2016 in Leipzig, Germany. The meeting brought together researchers and clinicians to share the latest knowledge on HPV infection in head and neck cancer and to join active and constructive scientific discussions. This report summarizes the major themes discussed during the symposium.

  14. CONFERENCE NOTE: Sixth Symposium on Temperature Scheduled for March 1982

    NASA Astrophysics Data System (ADS)

    1981-07-01

    The call for papers for the 6th Symposium on Temperature, Its Measurement and Control in Science and Industry has been issued. The Symposium is scheduled to take place in Washington, DC, USA during the week of March 14 18, 1982. Like its predecessors held in the years 1919, 1939, 1954, 1961, and 1971, the 6th Symposium will stress advances in the measurement of thermodynamic values of temperature, in temperature reference points, in temperature sensors and instruments for the control of temperature, and in the development and use of temperature scales. For the first time, an exhibit of thermometry will be a part of the Symposium. Manuscripts to be submitted for inclusion in the Symposium should be sent to the 6th Temperature Symposium Program Chairman, National Bureau of Standards, by September 15, 1981. Those papers accepted for the Symposium will be due in camera-ready form by February 15, 1982. Original papers on all of the topics listed above, as well as reviews of the past decade's progress in thermometry and temperature control, are solicited by the Symposium organizers. The Symposium arrangements and registration are in the care of the Instrument Society of America (represented on the Symposium General Committee by Mr C T Glazer, 67 Alexander Drive, PO Box 12277, Research Triangle Park, North Carolina, 27709, USA). Questions regarding the instrument exhibits should also be addressed to the ISA. The technical program for the Symposium is the responsibility of a committee headed by Dr J F Schooley, Room B-128 Physics Building, National Bureau of Standards, Washington, DC, 20234, USA. The Symposium proceedings will be published by the American Institute of Physics.

  15. Histamine (Scombroid) Fish Poisoning: a Comprehensive Review.

    PubMed

    Feng, Charles; Teuber, Suzanne; Gershwin, M Eric

    2016-02-01

    Histamine fish poisoning, also known as scombroid poisoning, is the most common cause of ichythyotoxicosis worldwide and results from the ingestion of histamine-contaminated fish in the Scombroidae and Scomberesocidae families, including mackerel, bonito, albacore, and skipjack. This disease was first described in 1799 in Britain and re-emerged in the medical literature in the 1950s when outbreaks were reported in Japan. The symptoms associated with histamine fish poisoning are similar to that of an allergic reaction. In fact, such histamine-induced reactions are often misdiagnosed as IgE-mediated fish allergy. Indeed, histamine fish poisoning is still an underrecognized disease. In this review, we discuss the epidemiology, pathophysiology, evaluation, and treatment of scombroid disease. Because more than 80% of fish consumed in the USA is now imported from other countries, the disease is intimately linked with the global fish trade (National Marine Fisheries Service, 2012). Preventing future scombroid outbreaks will require that fishermen, public health officials, restaurant workers, and medical professionals work together to devise international safety standards and increase awareness of the disease. The implications of scombroid poisoning go far beyond that of fish and have broader implications for the important issues of food safety.

  16. Laser induced damage in optical materials: 8th ASTM symposium.

    PubMed

    Glass, A J; Guenther, A H

    1977-05-01

    The Eighth Annual Symposium on Optical Materials for High Power Lasers (Boulder Damage Symposium) was hosted by the National Bureau of Standards in Boulder, Colorado, from 13 to 15 July 1976. The Symposium was held under the auspices of ASTM Committee F-1, Subcommittee on Laser Standards, with the joint sponsorship of NBS, the Defense Advanced Research Project Agency, the Energy Research and Development Administration, and the Office of Naval Research. About 160 scientists attended the Symposium, including representatives of the United Kingdom, France, Canada, and Brazil. The Symposium was divided into five half-day sessions concerning Bulk Material Properties and Thermal Behavior, Mirrors and Surfaces, Thin Film Properties, Thin Film Damage, and Scaling Laws and Fundamental Mechanisms. As in previous years, the emphasis of the papers presented at the Symposium was directed toward new frontiers and new developments. Particular emphasis was given to new materials for use at 10.6 microm in mirror substrates, windo s, and coatings. New techniques in film deposition and advances in diamond-turning of optics were described. The scaling of damage thresholds with pulse duration, focal area, and wavelength were discussed. Alexander J. Glass of Lawrence Livermore Laboratory and Arthur H. Guenther of the Air Force Weapons Laboratory were co-chairpersons of the Symposium. The Ninth Annual Symposium is scheduled for 4-6 October 1977 at the National Bureau of Standards, Boulder, Colorado.

  17. 43rd Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Boesiger, Edward A.

    2016-01-01

    The Aerospace Mechanisms Symposium (AMS) provides a unique forum for those active in the design, production and use of aerospace mechanisms. A major focus is the reporting of problems and solutions associated with the development and flight certification of new mechanisms. Sponsored and organized by the Mechanisms Education Association, responsibility for hosting the AMS is shared by the National Aeronautics and Space Administration and Lockheed Martin Space Systems Company (LMSSC). Now in its 43rd symposium, the AMS continues to be well attended, attracting participants from both the U.S. and abroad. The 43rd AMS was held in Santa Clara, California on May 4, 5 and 6, 2016. During these three days, 42 papers were presented. Topics included payload and positioning mechanisms, components such as hinges and motors, CubeSats, tribology, and mechanism testing. Hardware displays during the supplier exhibit gave attendees an opportunity to meet with developers of current and future mechanism components. The high quality of this symposium is a result of the work of many people, and their efforts are gratefully acknowledged. This extends to the voluntary members of the symposium organizing committee representing the eight NASA field centers, LMSSC, and the European Space Agency. Appreciation is also extended to the session chairs, the authors, and particularly the personnel at ARC responsible for the symposium arrangements and the publication of these proceedings. A sincere thank you also goes to the symposium executive committee who is responsible for the year-to-year management of the AMS, including paper processing and preparation of the program. The use of trade names of manufacturers in this publication does not constitute an official endorsement of such products or manufacturers, either expressed or implied, by the National Aeronautics and Space Administration.

  18. Report of the International Symposium on Phytochemicals in Medicine and Food (ISPMF 2015).

    PubMed

    Xiao, Jianbo

    2016-08-01

    The International Symposium on Phytochemicals in Medicine and Food (ISPMF2015) was held June 26-29, 2015, in Shanghai, China. This is the first time that a PSE meeting has been held in Asia and a PSE-PSA joint symposium provided an opportunity for communication between scientists from European and Asian countries. More than 270 scientists from 48 countries attended this meeting. ISPMF2015 assembled an exciting and diverse programme with 16 sessions, consisting of 12 plenary lectures, 20 invited talks, 55 short oral presentations, and in excess of 130 posters, dedicated to creating a podium for exchanging the latest research results on phytochemicals for food and human health. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Highlights of the 8th International Veterinary Immunology Symposium

    USDA-ARS?s Scientific Manuscript database

    Veterinary immunologists have expanded understanding of the immune systems for our companion animals and developed new vaccines and therapeutics. This manuscript summarizes the highlights of the 8th International Veterinary Immunology Symposium (8 th IVIS) held August 15th-19th, 2007, in Ouro Preto,...

  20. Proceedings of the coast redwood forests in a changing California: A symposium for scientists and managers

    Treesearch

    Richard B. Standiford; Theodore J. Weller; Douglas D. Piirto; John D Stuart

    2012-01-01

    The Coast Redwood Forests in a Changing California Science Symposium was held June 21-23, 2011 at UC Santa Cruz with just under 300 registrants in attendance. Participants ranged in background from graduate level students to university forestry faculty, land managers, and conservation groups, public agencies, and land trust members. The symposium was...

  1. Proceedings of the Symposium on Social Aspects and Recreation Research, February 19-22, 1992, Ontario, California

    Treesearch

    Deborah J. Chavez

    1992-01-01

    The growing demand for recreation at the wildland-urban interface throughout the United States poses new challenges for natural resource managers. To enable resource managers and researchers to exchange information and ideas, the first Symposium on Social Aspects and Recreation Research was held. The format of the symposium offered various opportunities for interactive...

  2. Brick and Click Libraries: Proceedings of an Academic Library Symposium (11th, Maryville, Missouri, November 4, 2011)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.

    2011-01-01

    Twenty-three scholarly papers and twelve abstracts comprise the content of the eleventh annual Brick and Click Libraries Symposium, held at Northwest Missouri State University in Maryville, Missouri. The peer-reviewed proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of…

  3. Brick and Click Libraries: Proceedings of an Academic Library Symposium (10th, Maryville, Missouri, November 5, 2010)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Ury, Connie Jo, Ed.; Park, Sarah G., Ed.

    2010-01-01

    Twenty-one scholarly papers and fifteen abstracts comprise the content of the tenth annual Brick and Click Libraries Symposium, held annually at Northwest Missouri State University in Maryville, Missouri. The peer-reviewed proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of…

  4. Symposium Review: Metal and Polymer Matrix Composites at MS&T 2013

    NASA Astrophysics Data System (ADS)

    Gupta, Nikhil; Paramsothy, Muralidharan

    2014-06-01

    This article reflects on the presentations made during the Metal and Polymer Matrix Composites symposium at Materials Science and Technology 2013 (MS&T'13) held in Montreal (Quebec, Canada) from October 27 to 31. The symposium had three sessions on metal matrix composites and one session on polymer matrix composites containing a total of 23 presentations. While the abstracts and full-text papers are available through databases, the discussion that took place during the symposium is often not captured in writing and gets immediately lost. We have tried to recap some of the discussion in this article and hope that it will supplement the information present in the proceedings. The strong themes in the symposium were porous composites, aluminum matrix composites, and nanocomposites. The development of processing methods was also of interest to the speakers and attendees.

  5. CHRONICLE: Third International Symposium on Modern Optics, Budapest, September 1988

    NASA Astrophysics Data System (ADS)

    Bukhenskiĭ, M. F.; Nikitin, P. I.; Semenov, A. S.

    1989-07-01

    The Third International Symposium on Modern Optics (Optics-88), held in Budapest on 13-16 September 1988, was organized by the Hungarian Optical, Acoustic, and Cinematographic Society with the support of the International Commission on Optics and various scientific and industrial organizations in Hungary. The International Symposium Committee was composed of leading specialists from 11 countries in Asia, America, and Europe with A. M. Prokhorov (USSR) and N. Kroo (Hungary) as Co-chairmen. The purpose of this regular symposium is to summarize the scientific and technical progress underlying the developments in optics itself, discuss the branches of science where progress depends on optical methods in devices, and draw the attention of specialists to the most promising trends which should yield results in the immediate future.

  6. Introduction--reproductive behavior: a symposium in honor of Frank A. Beach, 1911-1988.

    PubMed

    Sachs, B D

    1990-01-01

    A symposium honoring the memory of Frank A. Beach (1911-1988) and celebrating his scientific contributions was held on June 12, 1989 during the 21st Conference on Reproductive Behavior (CRB). The papers arising from the symposium are introduced after a very brief history of the CRB and its origins in an annual meeting of West Coast American sex researchers that was organized by Frank Beach and his colleagues.

  7. Antigen-specific histamine release in dogs with food hypersensitivity.

    PubMed

    Ishida, Rinei; Masuda, Kenichi; Sakaguchi, Masahiro; Kurata, Keigo; Ohno, Koichi; Tsujimoto, Hajime

    2003-03-01

    An in vitro evidence of IgE-mediated hypersensitivity to food allergens was detected by positive results of antigen-specific histamine release in dogs with food hypersensitivity. Eight dogs were diagnosed to have food hypersensitivity based on identification of offending food allergens with food elimination followed by oral food provocation. The percentages of histamine release against the stimulation of offending food allergens in the cases ranged from 2.1% to 70.9%. Six of the 8 cases showed histamine release higher than those of healthy control dogs. Four dogs showed relatively high histamine release at the percentage beyond 10% that was compatible with a positive value of histamine release in humans with food hypersensitivity. These findings would suggest that IgE-mediated hypersensitivity against food allergens could be involved in canine food hypersensitivity.

  8. Brick and Click Libraries: Proceedings of an Academic Libraries Symposium (8th, Maryville, Missouri, November 7, 2008)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Ury, Connie Jo, Ed.; Park, Sarah G., Ed.

    2008-01-01

    Eighteen scholarly papers and eighteen abstracts comprise the content of the 8th "Brick and Click Libraries Symposium," held annually at Northwest Missouri State University in Maryville, Missouri. The proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of librarianship. Many of the…

  9. Brick and Click Libraries: Proceedings of an Academic Library Symposium (6th, Maryville, Missouri, November 3, 2006)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Ury, Connie Jo, Ed.; Park, Sarah G., Ed.

    2006-01-01

    These proceedings document the sixth year of the "Brick and Click Libraries Symposium," held annually at Northwest Missouri State University in Maryville, Missouri, on November 3, 2006. Thirty-four peer-reviewed papers and abstracts, written by academic librarians, and presented at the symposium are included in this volume. Many of the…

  10. Highlights from the tenth ISCB Student Council Symposium 2014

    PubMed Central

    2015-01-01

    This report summarizes the scientific content and activities of the annual symposium organized by the Student Council of the International Society for Computational Biology (ISCB), held in conjunction with the Intelligent Systems for Molecular Biology (ISMB) conference in Boston, USA, on July 11th, 2014. PMID:25708534

  11. Symposium Summary

    NASA Astrophysics Data System (ADS)

    Levesque, Emily M.

    2017-11-01

    This proceeding summarizes the highlights of IAU 329, ``The Lives and Death-Throes of Massive Stars'', held in Auckland, NZ from 28 Nov - 2 Dec. I consider the progress that has been made in the field over the course of these ``beach symposia'', outline the overall content of the conference, and discuss how the current subfields in massive stellar astrophysics have evolved in recent years. I summarize some of the new results and innovative approaches that were presented during the symposium, and conclude with a discussion of how current and future resources in astronomy can serve as valuable tools for studying massive stars in the coming years.

  12. Histamine Levels in Fish from Markets in Lima, Perú†

    PubMed Central

    Gonzaga, Victor E.; Lescano, Andres G.; Huamán, Alfredo A.; Salmón-Mulanovich, Gabriela; Blazes, David L.

    2014-01-01

    Illnesses associated with seafood are an important public health concern worldwide, particularly considering the steady increase in seafood consumption. However, research about the risks associated with seafood products is scarce in developing countries. Histamine fish poisoning is the most common form of fish intoxication caused by seafood and usually presents as an allergic reaction. This condition occurs when fish are not kept appropriately refrigerated and histamine is formed in the tissues. Histamine levels of >500 ppm usually are associated with clinical illness. We assessed histamine levels in fish from markets in Lima, Peru, with a quantitative competitive enzyme-linked immunosorbent assay. Thirty-eight specimens were purchased from wholesale and retail markets: 17 bonito (Sarda sarda), 16 mackerel (Scomber japonicus peruanus), and 5 mahi-mahi (Coryphaena hippurus). Seven fish (18%) had histamine levels of 1 to 10 ppm (three mackerel and four bonito) and three (8%) had >10 ppm (three mackerel, 35 to 86 ppm). Fish from retail markets had detectable histamine levels (>1 ppm) more frequently than did fish bought at wholesale fish markets: 9 (36%) of 25 fish versus 1 (8%) of 13 fish, respectively (P = 0.063). Higher histamine levels were correlated with later time of purchase during the day (Spearman’s rho = 0.37, P = 0.024). Mackerel purchased at retail markets after 2 p.m. had a 75% prevalence of histamine levels of >10 ppm. Mackerel purchased late in the day in retail markets frequently contained high histamine levels, although the overall prevalence of elevated histamine levels was low. Despite the small sample, our findings highlight the need to reinforce seafood safety regulations and quality control in developing countries such as Peru. PMID:19517744

  13. Highlights from the ISCB Student Council Symposium 2013

    PubMed Central

    2014-01-01

    This report summarizes the scientific content and activities of the annual symposium organized by the Student Council of the International Society for Computational Biology (ISCB), held in conjunction with the Intelligent Systems for Molecular Biology (ISMB) / European Conference on Computational Biology (ECCB) conference in Berlin, Germany, on July 19, 2013. PMID:25077567

  14. The C3E Women in Clean Energy Symposium

    ScienceCinema

    Saylors-Laster, Kim; Kirsch, Emily; Brown, Sandra; Jordan, Rhonda; Mukherjee, Anuradha; Martin, Cheryl; Madden, Alice; Araujo, Kathy

    2018-02-13

    The Clean Energy Education & Empowerment initiative (C3E), provides a forum for thought leaders across the clean energy sector to devise innovative solutions to the nation's most pressing energy challenges. This year, the symposium was held at MIT's Media Lab in Cambridge, MA, on September 19-20, 2013. What sets the annual conference apart is its focus on building a strong community of professionals dedicated to advancing more women leaders in clean energy fields. By working to leverage the skills, talents and perspectives of women, the symposium helps to better position the U.S. to lead the global clean energy revolution.

  15. Third International Symposium on Magnetic Suspension Technology. Part 2

    NASA Technical Reports Server (NTRS)

    Groom, Nelson J. (Editor); Britcher, Colin P. (Editor)

    1996-01-01

    In order to examine the state of technology of all areas of magnetic suspension and to review recent developments in sensors, controls, superconducting magnet technology, and design/implementation practices, the Third International Symposium on Magnetic Suspension Technology was held at the Holiday Inn Capital Plaza in Tallahassee, Florida on 13-15 Dec. 1995. The symposium included 19 sessions in which a total of 55 papers were presented. The technical sessions covered the areas of bearings, superconductivity, vibration isolation, maglev, controls, space applications, general applications, bearing/actuator design, modeling, precision applications, electromagnetic launch and hypersonic maglev, applications of superconductivity, and sensors.

  16. Second International Symposium on Magnetic Suspension Technology, part 1

    NASA Technical Reports Server (NTRS)

    Groom, Nelson J. (Editor); Britcher, Colin P. (Editor)

    1994-01-01

    In order to examine the state of technology of all areas of magnetic suspension and to review related recent developments in sensors and controls approaches, superconducting magnet technology, and design/implementation practices, the Second International Symposium on Magnetic Suspension Technology was held. The symposium included 18 technical sessions in which 44 papers were presented. The technical sessions covered the areas of bearings, bearing modeling, controls, vibration isolation, micromachines, superconductivity, wind tunnel magnetic suspension systems, magnetically levitated trains (MAGLEV), rotating machinery and energy storage, and applications. A list of attendees appears at the end of the document.

  17. Third annual symposium on Frontiers of Engineering: Reports on leading edge engineering from the 1997 NAE symposium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hunziker, Janet

    1998-06-01

    This book is the third publication highlighting the presentations of the National Academy of Engineering's (NAE) symposium series, Frontiers of Engineering. The Third Annual NAE Symposium on Frontiers of Engineering was held September 18-20, 1997, at the Beckman Center in Irvine, California. The 101 emerging engineering leaders from industry, academia, and federal laboratories who attended the meeting heard presentations and discussed pioneering research and technical work in a variety of engineering fields. Symposium speakers were asked to prepare extended abstracts of their presentations, and those papers are contained herein. Fifteen papers are organized under the following five headings: biomechanics, sensorsmore » and control for manufacturing processes, safety and security issues, decision-making tools for design and manufacturing, and intelligent transportation systems. Talks focused on such topics as implant design and technology, design and application of optical fiber sensors, quadrupole resonance explosive detection systems, multicriteria evaluation of manufacturing performance, and automated highway systems. The after-dinner speech, which focused on today's rapid pace of change, is also included.« less

  18. 2012 household travel survey symposium : conference summary and final report.

    DOT National Transportation Integrated Search

    2013-12-01

    The SWUTC Travel Survey Symposium was held in Dallas on November 8 and 9. More than 70 travel : survey professionals attended this event from across the United States, from Florida to Alaska, with one : attendee from the City of Calgary (Canada), rep...

  19. Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels

    PubMed Central

    Schneider, Elke; Machavoine, François; Pléau, Jean-Marie; Bertron, Anne-France; Thurmond, Robin L.; Ohtsu, Hiroshi; Watanabe, Takehiko; Schinkel, Alfred H.; Dy, Michel

    2005-01-01

    In this study, we identify the bidirectional organic cation transporter 3 (OCT3/Slc22a3) as the molecule responsible for histamine uptake by murine basophils. We demonstrate that OCT3 participates in the control of basophil functions because exogenous histamine can inhibit its own synthesis—and that of interleukin (IL)-4, IL-6, and IL-13—through this means of transport. Furthermore, ligands of H3/H4 histamine receptors or OCT3 inhibit histamine uptake, and outward transport of newly synthesized histamine. By doing so, they increase the histamine content of basophils, which explains why they mimic the effect of exogenous histamine. These drugs were no longer effective in histamine-free histidine decarboxylase (HDC)-deficient mice, in contrast with histamine itself. Histamine was not taken up and lost its inhibitory effect in mice deficient for OCT3, which proved its specific involvement. Intracellular histamine levels were increased strongly in IL-3–induced OCT3 −/− bone marrow basophils, and explained why they generated fewer cytokines than their wild-type counterpart. Their production was enhanced when histamine synthesis was blocked by the specific HDC inhibitor α-fluoro-methyl histidine, and underscored the determinant role of histamine in the inhibitory effect. We postulate that pharmacologic modulation of histamine transport might become instrumental in the control of basophil functions during allergic diseases. PMID:16061728

  20. PROCEEDINGS: 1989 JOINT SYMPOSIUM ON STATIONARY COMBUSTION NOX CONTROL, SAN FRANCISCO, CA, MARCH 6-9, 1989 VOLUME 1

    EPA Science Inventory

    The proceedings document presentations at the 1989 Joint Symposium on Stationary Combustion NOx Control, held March 6-9, 1989, in San Francisco, CA. The symposium, sponsored by the U. S. EPA and EPRl, was the fifth in a series devoted solely to the discussion of control of NOx em...

  1. PROCEEDINGS: 1989 JOINT SYMPOSIUM ON STATIONARY COMBUSTION NOX CONTROL, SAN FRANCISCO, CA, MARCH 6-9, 1989 VOLUME 2

    EPA Science Inventory

    The proceedings document presentations at the 1989 Joint Symposium on Stationary Combustion NOx Control, held March 6-9. 1989. in San Francisco, CA. The symposium, sponsored by the U.S. EPA and EPRI, was the fifth in a series devoted solely to the discussion of control of NOx emi...

  2. Regulation of the Cardiovascular System by Histamine.

    PubMed

    Hattori, Yuichi; Hattori, Kohshi; Matsuda, Naoyuki

    2017-01-01

    Histamine mediates a wide range of cellular responses, including allergic and inflammatory reactions, gastric acid secretion, and neurotransmission in the central nervous system. Histamine also exerts a series of actions upon the cardiovascular system but may not normally play a significant role in regulating cardiovascular function. During tissue injury, inflammation, and allergic responses, mast cells (or non-mast cells) within the tissues can release large amounts of histamine that leads to noticeable cardiovascular effects. Owing to intensive research during several decades, the distribution, function, and pathophysiological role of cardiovascular H 1 - and H 2 -receptors has become recognized adequately. Besides the recognized H 1 - and H 2 -receptor-mediated cardiovascular responses, novel roles of H 3 - and H 4 -receptors in cardiovascular physiology and pathophysiology have been identified over the last decade. In this review, we describe recent advances in our understanding of cardiovascular function and dysfunction mediated by histamine receptors, including H 3 - and H 4 -receptors, their potential mechanisms of action, and their pathological significance.

  3. PROCEEDINGS OF THE 1990 EPA/AWMA INTERNATIONAL SYMPOSIUM: MEASUREMENT OF TOXIC AND RELATED AIR POLLUTANTS

    EPA Science Inventory

    The 1990 EPA/AWMA Symposium was held May 1-4, 1990 in Raleigh, N.C. he technical program consisted of 178 presentations held in 2O separate sessions. he sessions focused on recent advances in the measurement and monitoring of toxic and related pollutants. ew sessions to the sympo...

  4. Osthole inhibits histamine-dependent itch via modulating TRPV1 activity.

    PubMed

    Yang, Niu-Niu; Shi, Hao; Yu, Guang; Wang, Chang-Ming; Zhu, Chan; Yang, Yan; Yuan, Xiao-Lin; Tang, Min; Wang, Zhong-Li; Gegen, Tana; He, Qian; Tang, Kehua; Lan, Lei; Wu, Guan-Yi; Tang, Zong-Xiang

    2016-05-10

    Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as an antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied the molecular mechanism of osthole in histamine-dependent itch by behavioral test, Ca(2+) imaging, and electrophysiological experiments. First, osthole clearly remitted the scratching behaviors of mice induced with histamine, HTMT, and VUF8430. Second, in cultured dorsal root ganglion (DRG) neurons, osthole showed a dose-dependent inhibitory effect to histamine. On the same neurons, osthole also decreased the response to capsaicin and histamine. In further tests, the capsaicin-induced inward currents were inhibited by osthole. These results revealed that osthole inhibited histamine-dependent itch by modulating TRPV1 activity. This study will be helpful in understanding how osthole exerts anti-pruritus effects and suggests that osthole may be a useful treatment medicine for histamine-dependent itch.

  5. Osthole inhibits histamine-dependent itch via modulating TRPV1 activity

    PubMed Central

    Yang, Niu-Niu; Shi, Hao; Yu, Guang; Wang, Chang-Ming; Zhu, Chan; Yang, Yan; Yuan, Xiao-Lin; Tang, Min; Wang, Zhong-li; Gegen, Tana; He, Qian; Tang, Kehua; Lan, Lei; Wu, Guan-Yi; Tang, Zong-Xiang

    2016-01-01

    Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as an antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied the molecular mechanism of osthole in histamine-dependent itch by behavioral test, Ca2+ imaging, and electrophysiological experiments. First, osthole clearly remitted the scratching behaviors of mice induced with histamine, HTMT, and VUF8430. Second, in cultured dorsal root ganglion (DRG) neurons, osthole showed a dose-dependent inhibitory effect to histamine. On the same neurons, osthole also decreased the response to capsaicin and histamine. In further tests, the capsaicin-induced inward currents were inhibited by osthole. These results revealed that osthole inhibited histamine-dependent itch by modulating TRPV1 activity. This study will be helpful in understanding how osthole exerts anti-pruritus effects and suggests that osthole may be a useful treatment medicine for histamine-dependent itch. PMID:27160770

  6. Radioprotective potential of histamine on rat small intestine and uterus

    PubMed Central

    Carabajal, E.; Massari, N.; Croci, M.; Martinel Lamas, D.; Prestifilippo, J.P.; Ciraolo, P.; Bergoc, R.M.; Rivera, E.S.; Medina, V.A.

    2012-01-01

    The aim of this study was to improve knowledge about histamine radioprotective potential investigating its effect on reducing ionising radiation-induced injury and genotoxic damage on the rat small intestine and uterus. Forty 10-week-old male and 40 female Sprague-Dawley rats were divided into 4 groups. Histamine and histamine-5Gy groups received a daily subcutaneous histamine injection (0.1 mg/kg) starting 24 h before irradiation. Histamine-5Gy and untreated-5Gy groups were irradiated with a dose of whole-body Cesium-137 irradiation. Three days after irradiation animals were sacrificed and tissues were removed, fixed, and stained with haematoxylin and eosin, and histological characteristics were evaluated. Proliferation, apoptosis and oxidative DNA markers were studied by immunohistochemistry, while micronucleus assay was performed to evaluate chromosomal damage. Histamine treatment reduced radiation-induced mucosal atrophy, oedema and vascular damage produced by ionising radiation, increasing the number of crypts per circumference (239±12 vs 160±10; P<0.01). This effect was associated with a reduction of radiation-induced intestinal crypts apoptosis. Additionally, histamine decreased the frequency of micronuclei formation and also significantly attenuated 8-OHdG immunoreactivity, a marker of DNA oxidative damage. Furthermore, radiation induced flattening of the endometrial surface, depletion of deep glands and reduced mitosis, effects that were completely blocked by histamine treatment. The expression of a proliferation marker in uterine luminal and glandular cells was markedly stimulated in histamine treated and irradiated rats. The obtained evidences indicate that histamine is a potential candidate as a safe radio-protective agent that might increase the therapeutic index of radiotherapy for intra-abdominal and pelvic cancers. However, its efficacy needs to be carefully investigated in prospective clinical trials. PMID:23361244

  7. Shortleaf pine restoration and ecology in the Ozarks: proceedings of a symposium

    Treesearch

    John M. Kabrick; Daniel C. Dey; David Gwaze

    2007-01-01

    Contains 27 papers and 14 extended abstracts from the symposium "Shortleaf pine restoration and ecology in the Ozarks" held November 7-9, 2006, at the University Plaza Hotel and Convention Center in Springfield, MO.

  8. Influence of iodinated contrast media on the activities of histamine inactivating enzymes diamine oxidase and histamine N-methyltransferase in vitro.

    PubMed

    Kuefner, M A; Feurle, J; Petersen, J; Uder, M; Schwelberger, H G

    2014-01-01

    Iodinated contrast media can cause pseudoallergic reactions associated with histamine release in significant numbers of patients. To clarify whether these adverse reactions may be aggravated by a compromised histamine catabolism we asked if radiographic contrast agents in vitro inhibit the histamine inactivating enzymes diamine oxidase (DAO) and histamine N-methyltransferase (HMT). Nine iodinated contrast agents were tested in vitro. Following pre-incubation of purified porcine kidney DAO and recombinant human HMT with 0.1-10mM of the respective contrast medium (H2O and specific inhibitors of DAO and HMT as controls) enzyme activities were determined by using radiometric micro assays. None of the contrast media irrespective of their structure showed significant inhibition of the activities of DAO and HMT. Pre-incubation of the enzymes with specific inhibitors led to complete inhibition of the respective enzymatic activity. The iodinated contrast media tested in vitro did not exhibit inhibition of histamine converting enzymes at physiologically relevant concentrations. However due to the in vitro character of this study these results do not directly reflect the in vivo situation. Copyright © 2012 SEICAP. Published by Elsevier Espana. All rights reserved.

  9. Proceedings of the First International Symposium on the Biological Interpretation of Dose from Accelerator-Produced Radiation, Held at the Lawrence Radiation Laboratory, Berkeley, California, March 13--16, 1967

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wallace, R.

    1967-03-13

    The objective of the meeting was to provide a companion meeting to the ''First Symposium on Accelerator Radiation Dosimetry and Experience'' which was held November 3-5, 1965, at the Brookhaven National Laboratory. This first symposium was limited in scope to an intensified discussion of dosimetry techniques. The biology which is associated with high energy radiation was specifically excluded, since it was the original plan to hold a second symposium devoted entirely to biology. Thus the present Symposium was a sequel to the first and they were inseparable in their objectives. Since those attending the BNL Symposium were almost entirely healthmore » physicists with a background in physical science and actively engaged in the solution of radiation protection problems at high energy accelerators, it was felt that it would be necessary to begin the BID Symposium with a general review session on radiation biology, in order to provide a biological background for the proper understanding of the later sessions. This first session was arranged to give the health physicist a meaningful transition from fundamental radiobiological considerations to current new research activities in high energy biology. In our opinion, and also based on the comments of several of those attending these objectives were quite well attained. The talks by Bond, Robertson, Brustad, Wolff, and Patt were quite exhaustive as an introduction to the several areas of specialization in radiobiology. The overall purpose of the meeting was of course to inform the health physicists about the state of knowledge in advanced biological research as it might apply to their problems. It has often been said that it takes a long time for laboratory findings to be applied in practical situations, but this is certainly not true in radiobiology. Through this conference and others like it, the most recent understanding of high energy radiobiology is available to the practicing health physicist and is probably used

  10. Blood histamine release: A new allergy blood test

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Faraj, B.A.; Gottlieb, G.R.; Camp, V.M.

    1985-05-01

    Allergen-mediated histamine release from human leukocytes represents an important model for in vitro studies of allergic reactions. The purpose of this study was to determine whether the measurement of histamine released in allergic patients (pts) by radioenzymatic assay following mixing of their blood with common allergens represents a reliable index for diagnosis of atopic allergy. Three categories of allergies were used: (1) housedust and mite; (2) cat and dog dander; (3) trees and grasses and ragweed mixture. The presence of allergy was established by intradermal skin testing in the study group of 82 pts. Significant atopy was defined as greatermore » than or equal to 3+ (overall range 0-4 +, negative to maximum) on skin testing. The test was carried out in tubes with 0.5 ml heparinized blood, 0.5 ml tris albumin buffer, and one of the allergens (60-100 PNU/ml). In 20 controls without allergy, there always was less than or equal to 4% histamine release (normal response). A significant allergen-mediated histamine release, ranging from 12 to 30% of the total blood histamine content, was observed in 96% of the pts with skin test sensitivity of greater than or equal to 3+. There was good agreement between skin testing and histamine release in terms of the allergen causing the response. Thus, measurement of histamine release in blood in response to allergen challenge represents a clinically useful in vitro test for the diagnosis of atopic allergy. Because data can be obtained from a single sample and are highly quantitative, this new method should have application to the longitudinal study of allergic pts and to the assessment of interventions.« less

  11. Human eosinophils - potential pharmacological model applied in human histamine H4 receptor research.

    PubMed

    Grosicki, Marek; Kieć-Kononowicz, Katarzyna

    2015-01-01

    Histamine and histamine receptors are well known for their immunomodulatory role in inflammation. In this review we describe the role of histamine and histamine H4 receptor on human eosinophils. In the first part of article we provide short summary of histamine and histamine receptors role in physiology and histamine related therapeutics used in clinics. We briefly describe the human histamine receptor H4 and its ligands, as well as human eosinophils. In the second part of the review we provide detailed description of known histamine effects on eosinophils including: intracellular calcium concentration flux, actin polymerization, cellular shape change, upregulation of adhesion proteins and cellular chemotaxis. We provide proofs that these effects are mainly connected with the activation of histamine H4 receptor. When examining experimental data we discuss the controversial results and limitations of the studies performed on isolated eosinophils. In conclusion we believe that studies on histamine H4 receptor on human eosinophils can provide interesting new biomarkers that can be used in clinical studies of histamine receptors, that in future might result in the development of new strategies in the treatment of chronic inflammatory conditions like asthma or allergy, in which eosinophils are involved.

  12. PUNISHING AND CARDIOVASCULAR EFFECTS OF INTRAVENOUS HISTAMINE IN RATS: PHARMACOLOGICAL SELECTIVITY

    PubMed Central

    Podlesnik, Christopher A.; Jimenez-Gomez, Corina

    2014-01-01

    Although drugs may serve as reinforcers or punishers of operant behavior, the punishing function has received much less experimental attention than the reinforcing function. A sensitive method for studying drug-induced punishment is to assess choice for a punished response over an unpunished response. In these experiments, rats chose between pressing one lever and receiving a sucrose pellet or pressing another lever and receiving a sucrose pellet plus an intravenous injection of histamine. When sucrose was delivered equally frequently for either the punished or the unpunished response, rats selected the unpunished lever consistently, but decreases in the punished response did not differ as a function of intravenous histamine dose (0.1–1 mg/kg/inj). Changing the procedure so that sucrose was delivered on the unpunished lever with p = .5 increased the rats’ responding on the punished lever with saline injections. In addition, the same range of histamine doses produced a much larger range of responses on the punished lever that was dose dependent. Using these procedures to assess the receptors mediating histamine’s effects, the histamine H1-receptor antagonists, pyrilamine and ketotifen, antagonized the punishing effect of histamine, but the histamine H2-receptor antagonist ranitidine did not. However, ranitidine pretreatments reduced histamine-induced heart-rate increases to a greater extent than did the histamine H1-receptor antagonists when administered at the same doses examined under conditions of histamine punishment. Overall, the present findings extend the general hypothesis that activation of histamine H1-receptors mediates the punishing effects of histamine. They also introduce methods for rapidly assessing pharmacological mechanisms underlying drug-induced punishment. PMID:23982898

  13. Highlights of the ecancer/SAC First International Prostate Cancer Symposium, 11–12 March 2016, Buenos Aires, Argentina

    PubMed Central

    Villalba, Marcelo Blanco; Bramajo, Marina; Bruno, Mario

    2016-01-01

    The ecancer/SAC First International Prostate Cancer Symposium, held in Buenos Aires, included national, regional, and international experts in the field of prostate cancer. More than 200 professionals from a variety of areas (clinical urologists, pathologists, oncologists, biologists, imaging specialists, radiation therapists, and generalist doctors, among others) attended, and they proposed multidisciplinary management of prostate pathology from the start in concordance with the ideas set forth by the organising committee. A radiotherapy workshop was also held during the symposium, in which new techniques and their possible uses were specifically discussed. In addition to the local doctors, Dr Lilian Faroni (COI Group, Rio de Janeiro, Brazil), Dr Leonardo Carmona (Chilean Head and Neck Institute, Chile), and Dr Anthony Addesa (Jupiter Medical Centre, Florida, USA) also participated in this symposium. PMID:27350786

  14. 77 FR 52753 - U.S. Customs and Border Protection 2012 East Coast Trade Symposium: “Expanding 21st Century...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection U.S. Customs and Border Protection 2012 East Coast Trade Symposium: ``Expanding 21st Century Global Partnerships'' AGENCY: U.S... 21st Century Global Partnerships.'' The format of this year's East Coast Symposium will be held with...

  15. International Symposium on Interfacial Joining and Surface Technology (IJST2013)

    NASA Astrophysics Data System (ADS)

    Takahashi, Yasuo

    2014-08-01

    Interfacial joining (bonding) is a widely accepted welding process and one of the environmentally benign technologies used in industrial production. As the bonding temperature is lower than the melting point of the parent materials, melting of the latter is kept to a minimum. The process can be based on diffusion bonding, pressure welding, friction welding, ultrasonic bonding, or brazing-soldering, all of which offer many advantages over fusion welding. In addition, surface technologies such as surface modification, spraying, coating, plating, and thin-film formation are necessary for advanced manufacturing, fabrication, and electronics packaging. Together, interfacial joining and surface technology (IJST) will continue to be used in various industrial fields because IJST is a very significant form of environmentally conscious materials processing. The international symposium of IJST 2013 was held at Icho Kaikan, Osaka University, Japan from 27-29 November, 2013. A total of 138 participants came from around the world to attend 56 oral presentations and 36 posters presented at the symposium, and to discuss the latest research and developments on interfacial joining and surface technologies. This symposium was also held to commemorate the 30th anniversary of the Technical Commission on Interfacial Joining of the Japan Welding Society. On behalf of the chair of the symposium, it is my great pleasure to present this volume of IOP Conference Series: Materials Science and Engineering (MSE). Among the presentations, 43 papers are published here, and I believe all of the papers have provided the welding community with much useful information. I would like to thank the authors for their enthusiastic and excellent contributions. Finally, I would like to thank all members of the committees, secretariats, participants, and everyone who contributed to this symposium through their support and invaluable effort for the success of IJST 2013. Yasuo Takahashi Chair of IJST 2013

  16. Interactions of the histamine and hypocretin systems in CNS disorders.

    PubMed

    Shan, Ling; Dauvilliers, Yves; Siegel, Jerome M

    2015-07-01

    Histamine and hypocretin neurons are localized to the hypothalamus, a brain area critical to autonomic function and sleep. Narcolepsy type 1, also known as narcolepsy with cataplexy, is a neurological disorder characterized by excessive daytime sleepiness, impaired night-time sleep, cataplexy, sleep paralysis and short latency to rapid eye movement (REM) sleep after sleep onset. In narcolepsy, 90% of hypocretin neurons are lost; in addition, two groups reported in 2014 that the number of histamine neurons is increased by 64% or more in human patients with narcolepsy, suggesting involvement of histamine in the aetiology of this disorder. Here, we review the role of the histamine and hypocretin systems in sleep-wake modulation. Furthermore, we summarize the neuropathological changes to these two systems in narcolepsy and discuss the possibility that narcolepsy-associated histamine abnormalities could mediate or result from the same processes that cause the hypocretin cell loss. We also review the changes in the hypocretin and histamine systems, and the associated sleep disruptions, in Parkinson disease, Alzheimer disease, Huntington disease and Tourette syndrome. Finally, we discuss novel therapeutic approaches for manipulation of the histamine system.

  17. Issues in Rural Primary Education in Europe: A Summary of a Symposium on Issues in Rural Education at the European Conference on Educational Research (Seville, Spain, September 25-29, 1996).

    ERIC Educational Resources Information Center

    Hargreaves, Linda M.

    This paper summarizes a symposium on issues in rural education held at the 1996 European Conference on Educational Research held in Seville, Spain. The symposium aimed to gather contextual information about rural primary schools and included presentations from researchers in Sweden, Finland, Scotland, Ireland, and Greece. Participants from the…

  18. Symposium on accelerator mass spectrometry

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1981-01-01

    The area of accelerator mass spectrometry has expanded considerably over the past few years and established itself as an independent and interdisciplinary research field. Three years have passed since the first meeting was held at Rochester. A Symposium on Accelerator Mass Spectrometry was held at Argonne on May 11-13, 1981. In attendance were 96 scientists of whom 26 were from outside the United States. The present proceedings document the program and excitement of the field. Papers are arranged according to the original program. A few papers not presented at the meeting have been added to complete the information on themore » status of accelerator mass spectrometry. Individual papers were prepared separately for the data base.« less

  19. Proceedings of the 6th European VLBI Network Symposium

    NASA Astrophysics Data System (ADS)

    Ros, Eduardo; Porcas, Richard W.; Lobanov, Andrei P.; Zensus, J. Anton

    This volume contains the papers presented at the 6th Symposium of the European VLBI Network, held in Bonn on 25-28 June 2002. The initial aim of these biennial gatherings of European VLBI practitioners was to review in a timely manner new results and technical developments related to Very Long Baseline Interferometry. Now, however, interest and participation in the EVN Symposia reaches far beyond Europe, reflecting the fact that scientific research and development programs are carried out to a high degree in international and often truly global collaborations. More than 120 scientists from around the world registered for participation in the Symposium. The Symposium was hosted by the Max-Planck-Institut für Radioastronomie and was held at the Gustav Stresemann Institut. In addition to the scientific sessions and poster presentations, the program included an EVN Users Meeting, an MPIfR versus Rest-of-the-World football match (highly appropriate given the competing World Cup event!), a visit to the MPIfR's 100m radio telescope in Effelsberg, and a Conference Dinner held in the nearby old walled town of Bad Müunstereifel. To maximize the usefulness of these proceedings (and possibly as a daring precedent) the Editors decided to demand the written versions of talks and posters and to complete the editorial work before the meeting, and to deliver the book to the participants at the beginning of the Symposium. We thank the authors for their cooperation in delivering publication-ready electronic manuscripts and for meeting the strict deadlines. It is highly gratifying that only a handful of the 100 presentations are not represented in this volume. The editors have made minor changes to some of the contributions in order to improve readability, and take responsibility for any errors arising from these changes. Besides the authors, many individuals have contributed to the preparation of the meeting and its proceedings. In addition to many members of the MPIfR staff, we

  20. Effects of Bidens pilosa L. var. radiata SCHERFF treated with enzyme on histamine-induced contraction of guinea pig ileum and on histamine release from mast cells.

    PubMed

    Matsumoto, Takayuki; Horiuchi, Masako; Kamata, Katsuo; Seyama, Yoshiyuki

    2009-06-01

    The medical mechanism against type I allergies is to block the release or production of chemical mediators from mast cells or to block the H(1)-receptor signaling. We previously reported that the anti-allergic action of the dry powder from Bidens pilosa L. var. radiata SCHERFF treated with the enzyme cellulosine (eMMBP) was dependent on the inhibition of histamine release from mast cells. Here, we investigate that the effect of fractions in eMMBP on the histamine-induced contraction in guinea pig ileum and on the release of histamine in rat peritoneal mast cells. The histamine-induced contraction in guinea pig ileum is dose-dependently inhibited by ketotifen, an antagonist of H(1)-receptor. Fractions contained caffeic acid, caffeoylquinic acid and fractions contained flavonoids such as hyperin and isoquercitrin in eMMBP inhibit histamine release from mast cells, but only flavonoids such as hyperin, isoquercitrin and rutin suppress the histamine-induced contraction in guinea pig ileum. Moreover, the histamine-induced contraction was not affected by caffeic acid, however, such contraction was significantly inhibited by rutin. These results suggest that the primary antagonists of H(1)- receptor are different from the components in eMMBP that inhibit histamine release, and that these components participate in the anti-allergic activity of eMMBP.

  1. Registration open for "Cancer and Immunotherapy: From Conception to Delivery" symposium | Center for Cancer Research

    Cancer.gov

    The Annual Immunology Symposium, sponsored by the CCR’s Center of Excellence in Immunology will be held this fall on October 12-13th in Masur and Lipsett Auditorium in Building 10.  This year’s theme is "Cancer Immunology and Immunotherapy:  From Conception to Delivery", and the symposium will be chaired by Drs. Nicholas Restifo and Steve Rosenberg.  Learn more...

  2. February NICBR Symposium Highlights Careers in Science | Poster

    Cancer.gov

    Poster Staff The first National Interagency Confederation for Biological Research (NICBR) Exploring Careers in a Scientific Environment Symposium was held on Feb. 18 at the Advanced Technology Research Facility. The event drew more than 70 Frederick County public school teachers, who learned about the wide range of biomedical research being conducted by scientists in the NICBR

  3. Evidence that histamine is the causative toxin of scombroid-fish poisoning.

    PubMed

    Morrow, J D; Margolies, G R; Rowland, J; Roberts, L J

    1991-03-14

    The highest morbidity worldwide from fish poisoning results from the ingestion of spoiled scombroid fish, such as tuna and mackerel, and its cause is not clear. Histamine could be responsible, because spoiled scombroid fish contain large quantities of histamine. Whether histamine is the causative toxin, however, has remained in question. To address this issue, we investigated whether histamine homeostasis is altered in poisoned people. The urinary excretion of histamine and its metabolite, N-methylhistamine, was measured in three persons who had scombroid-fish poisoning (scombrotoxism) after the ingestion of marlin. We measured 9 alpha, 11 beta-dihydroxy-15-oxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid (PGD-M), the principal metabolite of prostaglandin D2, a mast-cell secretory product, to assess whether mast cells had been activated to release histamine. The fish contained high levels of histamine (842 to 2503 mumol per 100 g of tissue). Symptoms of scombrotoxism--flushing and headache--began 10 to 30 minutes after the ingestion of fish. In urine samples collected one to four hours after fish ingestion, the levels of histamine and N-methylhistamine were 9 to 20 times and 15 to 20 times the normal mean, respectively. During the subsequent 24 hours, the levels fell to 4 to 15 times and 4 to 11 times the normal values. Levels of both were normal 14 days later. PGD-M excretion was not increased at any time. Two persons treated with diphenhydramine had prompt amelioration of symptoms. Scombroid-fish poisoning is associated with urinary excretion of histamine in quantities far exceeding those required to produce toxicity. The histamine is most likely derived from the spoiled fish. These results identify histamine as the toxin responsible for scombroid-fish poisoning.

  4. Brick and Click Libraries: Proceedings of an Academic Library Symposium (Northwest Missouri State University, Maryville, Missouri, October 14, 2005)

    ERIC Educational Resources Information Center

    Ury, Connie Jo., Ed.; Baudino, Frank, Ed.

    2005-01-01

    These proceedings document the fifth year of the "Brick and Click Libraries Symposium", held annually at Northwest Missouri State University in Maryville, Missouri. Thirty five peer-reviewed papers and abstracts, written by academic librarians, and presented at the symposium are included in this volume. Many of the entries have…

  5. 38th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Boesiger, Edward A. (Compiler)

    2006-01-01

    The Aerospace Mechanisms Symposium (AMS) provides a unique forum for those active in the design, production and use of aerospace mechanisms. A major focus is the reporting of problems and solutions associated with the development and flight certification of new mechanisms. Organized by the Mechanisms Education Association, the National Aeronautics and Space Administration and Lockheed Martin Space Systems Company (LMSSC) share the responsibility for hosting the AMS. Now in its 38th symposium, the AMS continues to be well attended, attracting participants from both the U.S. and abroad. The 38th AMs, hosted by the NASA Langley Research Center in Williamsburg, Virginia, was held May 17-19, 2006. During these three days, 34 papers were presented. Topics included gimbals, tribology, actuators, aircraft mechanisms, deployment mechanisms, release mechanisms, and test equipment. Hardware displays during the supplier exhibit gave attendees an opportunity to meet with developers of current and future mechanism components.

  6. 39th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Boesiger, E. A. (Compiler)

    2008-01-01

    The Aerospace Mechanisms Symposium (AMS) provides a unique forum for those active in the design, production, and use of aerospace mechanisms. A major focus is the reporting of problems and solutions associated with the development and flight certification of new mechanisms. Organized by the Mechanisms Education Association, NASA Marshall Space Flight Center (MSFC) and Lockheed Martin Space Systems Company (LMSSC) share the responsibility for hosting the AMS. Now in its 39th symposium, the AMS continues to be well attended, attracting participants from both the United States and abroad. The 39th AMS was held in Huntsville, Alabama, May 7-9, 2008. During these 3 days, 34 papers were presented. Topics included gimbals and positioning mechanisms, tribology, actuators, deployment mechanisms, release mechanisms, and sensors. Hardware displays during the supplier exhibit gave attendees an opportunity to meet with developers of current and future mechanism components.

  7. The National Library of Medicine's 2004 "Symposium on community-based health information outreach". Introduction.

    PubMed

    Peay, Wayne J; Rockoff, Maxine L

    2005-10-01

    This paper introduces the special supplement to the Journal of the Medical Library Association (JMLA) that documents the proceedings of the "Symposium on Community-based Health Information Outreach" held on December 2 and 3, 2004, at the National Library of Medicine (NLM). The goal of the symposium was to explore new models of health information outreach that are emerging as technology dramatically changes the abilities of medical and health services libraries to provide resources and services beyond their traditional institutional boundaries, with particular concern for consumer health information outreach through community-based organizations. The symposium's primary objectives were to learn about successful and promising work that had already been done as well as to develop a vision for the future that could inform the NLM's next National Network of Libraries of Medicine (NN/LM) contract. Another objective was to review and assess the NLM's Strategic Plan to Reduce Health Disparities with special emphasis on Native Americans. The paper describes the background events and rationale that led to the NLM's decision to convene the symposium and summarizes the supplement's ten other papers, some of which were presented at the symposium and some of which were written afterward to capture the symposium's working sessions. The symposium convened approximately 150 invited participants with a wide variety of perspectives and experience. Sessions were held to present exemplary outreach projects, to review the NLM's Strategic Plan to Reduce Health Disparities, to summarize the research underpinnings for evaluating outreach projects, and to provide a futurist's perspective. A panel of community representatives gave voice to the participants in outreach projects, and sixteen posters describing outreach projects were available, many of them with community representatives on hand to explain the work. This JMLA supplement provides a comprehensive summary of the state of the art

  8. Histamine content does not influence the tolerance of wine in normal subjects.

    PubMed

    Kanny, G; Bauza, T; Frémont, S; Guillemin, F; Blaise, A; Daumas, F; Cabanis, J C; Nicolas, J P; Moneret-Vautrin, D A

    1999-02-01

    Histamine has been incriminated as having a responsibility for intolerance reaction to wines. We have made a study by double blind oral provocation test to find the effect of ingestion of a histamine-rich (22.8 mg.l-1) and a histamine free wine in eight healthy subjects. Blood samples were taken at 0, 10, 30 and 45 minutes after ingestion of the wine for measurement of plasma histamine and methylhistamine. Urines were collected 5 hours before and 5 hours after ingestion for measurement of urinary methylhistamine. No subject presented a reaction of intolerance after ingestion of wine rich or poor in histamine. No change in plasma histamine and plasma and urinary methylhistamine was seen. This study shows that the amount of histamine in wine has no clinical or biological effect in healthy subjects, and this emphasized the efficiency in man of the systems for degradation of histamine that is absorbed by the alimentary tract.

  9. meeting summary 10th AMS Symposium on Education.

    NASA Astrophysics Data System (ADS)

    Smith, D. R.; Hayes, M. C.; Ramamurthy, M. K.; Zeitler, J. W.; Murphy, K. A.; Croft, P. J.; Nese, J. M.; Friedman, H. A.; Robinson, H. W.; Thormeyer, C. D.; Ruscher, P. A.; Pandya, R. E.

    2001-12-01

    The American Meteorological Society held its 10th Symposium on Education in conjunction with the 82nd Annual Meeting in Albuquerque, New Mexico. The theme of 2001's symposium was enhancing public awareness of the atmospheric and oceanic environments. Thirty-six oral presentations and 38 poster presentations summarized a variety of educational programs or examined educational issues at both the precollege and university levels. There was a special session on increasing awareness of meteorology and oceanography through popular and informal educational activities, as well as a joint session with the 17th International Conference on Interactive Information and Processing Systems (IIPS) for Meteorology, Oceanography, and Hydrology on using the World Wide Web to deliver information pertaining to the atmosphere, oceans, and coastal zone. Over 200 people representing a wide spectrum of the Society attended one or more of the sessions in this 2-day conference. The program for the 10th Symposium on Education can be viewed in the November 2000 issue of the Bulletin.

  10. Updosing of Nonsedating Anti-histamines in Recalcitrant Chronic Urticaria

    PubMed Central

    Godse, Kiran; Bhattar, Prachi; Patil, Sharmila; Nadkarni, Nitin; Gautam, Manjyot

    2016-01-01

    Chronic urticaria (CU) is a persistent, debiliating condition that causes severe impairment on the quality of life (QoL) of patient by interrupting work productivity. Current guidelines recommend second-generation (nonsedating) anti-histamines for the treatment for all forms of urticaria. In patients who do not respond adequately to conventional doses of anti-histamines, it is recommended to increase the dose to up to four times to obtain control. But there are only few controlled studies that have assessed the efficacy and safety of nonsedating anti-histamines. Though sedating histamines are frequently used as an add-on therapy in severe cases, they have a negative impact on QoL by compromising sleep and performance. The use of other suggested therapeutic options (omalizumab, cyclosporine A, montelukast and dapsone) is also limited by paucity of data on their efficacy and adverse effect profile. Second-generation anti-histamines which are relatively safer require more proven data to support their judicious use to improve disease in patients with CU. PMID:27293247

  11. The Physics of Beams: The Andrew Sessler Symposium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barletta, W.A.

    1996-03-01

    These proceedings represent papers presented at the Andrew Sessler Symposium held at the Lawrence Berkeley National Laboratory in honor of Andrew Sessler{close_quote}s over forty years of major scientific contributions to accelerator and beam physics as well as in celebration of his 65th birthday. The symposium was sponsored by the United States Department of Energy. The topics discussed include linear colliders, past history and future speculations, ELOISATRON at 100 TeV beam, manipulating charged particle beams by means of plasma and collective instabilities in accelerator and storage rings. There were 10 papers presented and 8 have been abstracted for the Energy Sciencemore » and Technology database.(AIP)« less

  12. Reaching the hip-hop generation: Final (symposium proceedings) report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    The goal of this final (closing) report is to capture the flavor of the symposium held March 1 and 2, 1993 in New York City convened by Motivational Educational Entertainment, Inc. (MEE), a black-owned communications research, consulting, and video production company based in Philadelphia, Pennsylvania. The mission of MEE is to understand, reach, and positively affect inner-city youth. Traditional communication approaches from mainstream sources to at-risk youth often don`t account for the unique way youth communicate among themselves and how they relate to the media. This understanding, however, is crucial. To understand youth communication, the people who create and sendmore » both entertaining and educational messages to urban youth must be brought into the dialogue. The meeting in New York was intended to provide an important opportunity for senders to meet and evaluate the appropriateness and effectiveness of their messages. In addition, the MEE symposium provided a forum for the continuing public debate about what needs to be done to reach today`s urban teens. Included in this document is a description of symposium goals/objectives, symposium activities, the reaction to and analysis of the symposium, recommendations for future MEE courses of action, and an appendix containing copies of press articles.« less

  13. Second International Symposium on Magnetic Suspension Technology, part 2

    NASA Technical Reports Server (NTRS)

    Groom, Nelson J. (Editor); Britcher, Colin P. (Editor)

    1994-01-01

    In order to examine the state of technology of all areas of magnetic suspension and to review related recent developments in sensors and controls approaches, superconducting magnet technology, and design/implementation practices, the 2nd International Symposium on Magnetic Suspension Technology was held at the Westin Hotel in Seattle, WA, on 11-13 Aug. 1993. The symposium included 18 technical sessions in which 44 papers were presented. The technical sessions covered the areas of bearings, bearing modelling, controls, vibration isolation, micromachines, superconductivity, wind tunnel magnetic suspension systems, magnetically levitated trains (MAGLEV), rotating machinery and energy storage, and applications. A list of attendees appears at the end of the document.

  14. Stimulation of cell proliferation by histamine H2 receptors in dimethylhdrazine-induced adenocarcinomata.

    PubMed

    Tutton, P J; Barkla, D H

    1978-03-01

    Cell proliferation in dimethylhydrazine-induced colonic carcinomata was stimulated by histamine and by the histamine H2 receptor agonist dimaprit and inhibited by the histamine H2 receptor antagonists Metiamide and Cimetidine but not by the histamine H1 receptor antagonist Mepyramine. In contrast histamine had no effect on colonic crypt cell proliferation in normal or dimethylhydrazine-treated rats.

  15. 76 FR 17137 - Pregnancy and Prescription Medication Use Symposium

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-28

    ...] Pregnancy and Prescription Medication Use Symposium AGENCY: Food and Drug Administration, HHS. ACTION: Notice of meeting. The Food and Drug Administration (FDA) is announcing the following meeting: Pregnancy... Pregnancy.'' Date and Time: The meeting will be held on May 17, 2011, from 8 a.m. to 4:30 p.m. Location: The...

  16. Third symposium on underground mining

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1977-01-01

    The Third Symposium on Underground Mining was held at the Kentucky Fair and Exposition Center, Louisville, KY, October 18--20, 1977. Thirty-one papers have been entered individually into EDB and ERA. The topics covered include mining system (longwall, shortwall, room and pillar, etc.), mining equipment (continuous miners, longwall equipment, supports, roof bolters, shaft excavation equipment, monitoring and control systems. Maintenance and rebuilding facilities, lighting systems, etc.), ventilation, noise abatement, economics, accidents (cost), dust control and on-line computer systems. (LTN)

  17. Highlights from the 6th International Society for Computational Biology Student Council Symposium at the 18th Annual International Conference on Intelligent Systems for Molecular Biology

    PubMed Central

    2010-01-01

    This meeting report gives an overview of the keynote lectures and a selection of the student oral and poster presentations at the 6th International Society for Computational Biology Student Council Symposium that was held as a precursor event to the annual international conference on Intelligent Systems for Molecular Biology (ISMB). The symposium was held in Boston, MA, USA on July 9th, 2010.

  18. Proceedings of the second symposium on social aspects and recreation research, February 23-25, 1994, San Diego, California

    Treesearch

    Deborah J. Chavez

    1995-01-01

    Examination of natural resources often leaves out one important component-the human element. To enable resource managers and researchers to exchange information and ideas about the human dimensions of natural resources, the second Symposium on Social Aspects and Recreation Research was held February 23-25, 1994, in San Diego, California. The format of the symposium...

  19. National Symposium on Children and Youth Who Are Deaf-Blind. Proceedings (McLean, Virginia, December 5-7, 1992).

    ERIC Educational Resources Information Center

    Reiman, John W., Ed.; Johnson, Pattie A., Ed.

    This national symposium was held to identify critical issues and "best practices" in providing services for individuals with deaf-blindness and to develop strategies for future actions. The symposium focused on several specific topical areas in an effort to find ways in which resources might be marshalled at the federal, state, local, family, and…

  20. Immunological release of histamine and slow-reacting substance in domestic fowl.

    PubMed Central

    Chand, N; Eyre, P

    1978-01-01

    Immunological release of histamine from the whole blood of the sensitized chickens was demonstrated. Compound 48/80 (a potent histamine releaser) released histamine from isolated chicken lung. The sensitizing antigens (bovine albumin or horse plasma) did not release histamine from the lung. Bovine albumin and horse plasma released slow-reacting substance of anaphylaxis only from the lungs of adult domestic fowl and not from ileum or lungs of immature chickens. PMID:84701

  1. SUMMARY OF DISCUSSION SESSIONS: SYMPOSIUM ON LEAD-BLOOD PRESSURE RELATIONSHIPS

    EPA Science Inventory

    The International Symposium on Lead-Blood Pressure Relationships was held in Chapel Hill, NC, April 27-29, 1987. The program was structured so as to first present an overview of theories and findings in the general area of human hypertension and then to have speakers review the e...

  2. Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine

    PubMed Central

    Kljun, Jakob; Petriček, Saša; Žigon, Dušan; Hudej, Rosana; Miklavčič, Damijan; Turel, Iztok

    2010-01-01

    Novel ruthenium(III) complexes with histamine [RuCl4(dmso-S)(histamineH)] · H2O (1a) and [RuCl4(dmso-S)(histamineH)] (1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine. Biological assays to test the cytotoxicity of the compound 1b combined with electroporation were performed to determine its potential for future medical applications in cancer treatment. PMID:20631838

  3. Overview of the International Symposium on Eurasian Ruffe (Gymnocephalus cernuus) Biology, Impacts, and Control

    USGS Publications Warehouse

    Gunderson, Jeffrey L.; Klepinger, Michael R.; Bronte, Charles R.; Marsden, J. Ellen

    1998-01-01

    The International Symposium on the Biology and Management of Ruffe was organized to address the potential threat ruffe pose to North American fisheries. Scientists in diverse disciplines from Eurasia and North America were brought together in an attempt to examine all aspects of the North American invasion of ruffe, and to highlight the effects of similar introductions in Europe and Asia. The symposium, sponsored by the Minnesota and Michigan Sea Grant College programs, featured 48 oral and poster presentations and was held in Ann Arbor, Michigan, during 21-23 March 1997. Papers from the symposium are published in a special section of this issue of the Journal of Great Lakes Research.

  4. NUC Symposium on Environmental Preservation, 20-21 May 1970.

    ERIC Educational Resources Information Center

    Naval Undersea Center, San Diego, CA.

    This publication consists of papers presented at an in-house symposium held at the Naval Undersea Research and Development (R and D) Center, San Diego, in May 1970. The topics discussed in these presentations are as follows: principles of evolution and the ecological crisis; alternatives to overpopulation; examples of San Diego noise climate;…

  5. Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings

    PubMed Central

    Francis, Taylor; Graf, Allyson; Hodges, Kyle; Kennedy, Lindsey; Hargrove, Laura; Price, Mattie; Kearney, Kate

    2013-01-01

    The pancreas is a dynamic organ that performs a multitude of functions within the body. Diseases that target the pancreas, like pancreatitis and pancreatic cancer, are devastating and often fatal to the suffering patient. Histamine and histamine receptors (H1-H4HRs) have been found to play a critical role in biliary diseases. Accordingly, the biliary tract and the pancreas share similarities with regards to morphological, phenotypical and functional features and disease progression, studies related the role of H1-H4HRs in pancreatic diseases are important. In this review, we have highlighted the role that histamine, histidine decarboxylase (HDC), histamine receptors and mast cells (the main source of histamine in the body) play during both pancreatitis and pancreatic cancer. The objective of the review is to demonstrate that histamine and histamine signaling may be a potential therapeutic avenue towards treatment strategies for pancreatic diseases. PMID:24570946

  6. CD-ROM Proceedings International Symposium on Erosion and Landscape Evolution (ISELE)

    USDA-ARS?s Scientific Manuscript database

    This CD-ROM contains the abstracts and full papers for the proceedings from the ASABE specialty conference, the International Symposium on Erosion and Landscape Evolution (ISELE), held September 18-21, 2011 at the Hilton Anchorage Hotel in Anchorage, Alaska. Three extended abstracts from the meeting...

  7. Reaching every child with rotavirus vaccine: Report from the 10th African rotavirus symposium held in Bamako, Mali.

    PubMed

    Sow, Samba O; Steele, A Duncan; Mwenda, Jason M; Armah, George E; Neuzil, Kathleen M

    2017-10-09

    The Center for Vaccine Development - Mali (CVD - Mali), the World Health Organization's regional office in Africa (WHO/AFRO), and the CVD at the University of Maryland School of Medicine hosted the 10th African Rotavirus Symposium in Bamako, Mali on 1-2 June 2016. The symposium is coordinated by WHO/AFRO, the Regional Rotavirus Reference Laboratories, and the African Rotavirus Network (ARN), with support from the Bill & Melinda Gates Foundation. The event brings together leading rotavirus researchers, scientists, and policy-makers from across Africa and the world. Over 150 participants, from 31 countries, including 27 in Africa, joined forces to address the theme "Reaching Every Child in Africa with Rotavirus Vaccines." This symposium, the first in francophone Africa, occurred at an unprecedented time when 33 African countries had introduced rotavirus vaccines into their national immunization programs. The symposium concluded with a Call to Action to introduce rotavirus vaccines in the 21 remaining African countries, to increase access in countries with existing vaccination programs, and to continue surveillance and research on rotavirus and other diarrheal diseases. Copyright © 2017.

  8. Acute Pancreatitis-Progress and Challenges: A Report on an International Symposium.

    PubMed

    Afghani, Elham; Pandol, Stephen J; Shimosegawa, Tooru; Sutton, Robert; Wu, Bechien U; Vege, Santhi Swaroop; Gorelick, Fred; Hirota, Morihisa; Windsor, John; Lo, Simon K; Freeman, Martin L; Lerch, Markus M; Tsuji, Yoshihisa; Melmed, Gil Y; Wassef, Wahid; Mayerle, Julia

    2015-11-01

    An international symposium entitled "Acute pancreatitis: progress and challenges" was held on November 5, 2014 at the Hapuna Beach Hotel, Big Island, Hawaii, as part of the 45th Anniversary Meeting of the American Pancreatic Association and the Japanese Pancreas Society. The course was organized and directed by Drs. Stephen Pandol, Tooru Shimosegawa, Robert Sutton, Bechien Wu, and Santhi Swaroop Vege. The symposium objectives were to: (1) highlight current issues in management of acute pancreatitis, (2) discuss promising treatments, (3) consider development of quality indicators and improved measures of disease activity, and (4) present a framework for international collaboration for development of new therapies. This article represents a compilation and adaptation of brief summaries prepared by speakers at the symposium with the purpose of broadly disseminating information and initiatives.

  9. Serum diamine oxidase activity as a diagnostic test for histamine intolerance.

    PubMed

    Mušič, Ema; Korošec, Peter; Šilar, Mira; Adamič, Katja; Košnik, Mitja; Rijavec, Matija

    2013-05-01

    Histamine intolerance (HIT) is characterized by an imbalance between histamine intake and the capacity for histamine degradation. The main enzyme for metabolizing ingested histamine is diamine oxidase (DAO). Determining DAO activity in serum may be useful in diagnosing HIT. Over a period of 3.5 years we recruited 316 subjects with clinically suspected HIT and 55 healthy controls. Serum DAO activity was measured with a quantitative enzyme immunoassay. Twenty patients with highly reduced DAO activity went on a histamine-free diet for 6-12 months. Afterwards, their DAO activity was determined again. We found that DAO activity was significantly lower in patients than in healthy control subjects (P < 0.0001). Furthermore, 54 patients had highly reduced serum DAO activity (< 40 HDU/ml). Their main symptoms involved the skin, gastrointestinal tract, respiratory system, and eyes. In all the 20 patients with highly reduced DAO activity, the main clinical symptoms typical of histamine intolerance disappeared after they adopted a histamine-free diet. Furthermore, the serum DAO activity values measured increased significantly (P < 0.0001). Our results suggest that determining DAO activity in serum is a useful tool in diagnosing HIT. Furthermore, our results showed the benefit of a histamine-free diet because after the diet the majority of symptoms disappeared and the serum DAO activity significantly increased.

  10. PROCEEDINGS: SYMPOSIUM ON FLUE GAS DESULFURIZATION HELD AT HOLLYWOOD, FLORIDA, NOVEMBER 1977. VOLUME II

    EPA Science Inventory

    The proceedings document presentations made during the symposium, which dealt with the status of flue gas desulfurization technology in the United States and abroad. Subjects considered included: regenerable, non-regenerable, and advanced processes; process costs; and by-product ...

  11. PROCEEDINGS: SYMPOSIUM ON FLUE GAS DESULFURIZATION HELD AT HOLLYWOOD, FLORIDA, NOVEMBER 1977. VOLUME I

    EPA Science Inventory

    The proceedings document presentations made during the symposium, which dealt with the status of flue gas desulfurization technology in the United States and abroad. Subjects considered included: regenerable, non-regenerable, and advanced processes; process costs; and by-product ...

  12. 37th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Boesiger, Edward A. (Compiler)

    2004-01-01

    The Aerospace Mechanisms Symposium (AMS) provides a unique forum for those active in the design, production and use of aerospace mechanisms. A major focus is reporting problems and solutions associated with the development and flight certification of new mechanisms. Organized by the Mechanisms Education Association, NASA and Lockheed Martin Space Systems Company (LMSSC) share the responsibility for hosting the AMS. Now in its 37th symposium, the AMS continues to be well attended, attracting participants from both the U.S. and abroad. The 37th AMS, hosted by the Johnson Space Center (JSC) in Galveston, Texas, was held May 19, 20 and 21, 2004. During these three days, 34 papers were presented. Topics included deployment mechanisms, tribology, actuators, pointing and optical mechanisms, Space Station and Mars Rover mechanisms, release mechanisms, and test equipment. Hardware displays during the supplier exhibit gave attendees an opportunity to meet with developers of current and future mechanism components.

  13. The 12th I. E. Melhus Graduate Student Symposium: host plant resistance and disease management, current status and future outlook

    USDA-ARS?s Scientific Manuscript database

    The 12th I. E. Melhus Graduate Student Symposium was held on 6 August 2012 during the Annual meeting of the American Phytopathological Society (APS) in Providence, RI. The theme for this symposium was “Host Plant Resistance and Disease Management: Current Status and Future Outlook”. The APS Host R...

  14. Using an Engaged Scholarship Symposium to Change Perceptions: Evaluation Results

    ERIC Educational Resources Information Center

    Varkey, Sapna; Smirnova, Olga; Gallien, Tara Lee

    2018-01-01

    Engaged scholarship (ES) entails a symbiotic relationship between the community and the university. This article reports results from an evaluation of an ES symposium Eastern Carolina University held to increase awareness of ES as a means for integrating research, teaching, and service and to potentially change unfavorable perceptions about ES…

  15. Histamine production by Klebsiella pneumoniae and an incident of scombroid fish poisoning.

    PubMed Central

    Taylor, S L; Guthertz, L S; Leatherwood, M; Lieber, E R

    1979-01-01

    A histamine-producing strain of Klebsiella pneumoniae was isolated from a sample of tuna sashimi implicated in an outbreak of scombroid fish poisoning. None of the other nine gram-negative bacterial strains isolated from the tuna sashimi was capable of equivalent histamine production. Bacterial histamine production was monitored in a tuna fish infusion broth (TFIB), and the implicated K. pneumoniae was capable of producing 442 mg of histamine per 100 g of tuna in TFIB in 7 h under controlled incubation conditions. Only 12 of 50 other K. pneumoniae strains, representing 5 distinct biochemical types, which had been originally isolated from foods, were able to produce such levels of histamine in TFIB. No correlation was found between histamine production and other biochemical characteristics or antibiotic resistance. Of the 12 histamine-producing strains, 11 belonged to type 2, which is characterized as indole negative with positive reactions in the urea and Voges-Proskauer tests. However, only 50% of the type 2 strains examined produced high levels of histamine in TFIB. Additionally, the implicated K. pneumoniae strain and one other strain belonged to type 1, which is characterized by positive reactions in the indole, urea, and Voges-Proskauer tests. PMID:373626

  16. Cold urticaria: inhibition of cold-induced histamine release by doxantrazole.

    PubMed

    Bentley-Phillips, C B; Eady, R A; Greaves, M W

    1978-10-01

    Thirteen patients with cold urticaria were studied to assess the effect of the systemic drug doxantrazole, which has actions resembling disodium cromoglycate, on cold evoked histamine release. The patients, all of whom developed an immediate local whealing response after cooling of the forearm, demonstrated release of histamine into venous blood draining that forearm. Following doxantrazole treatment, significant suppression of histamine release occurred. In some but not all patients this was accompanied by diminution of urtication in response to cooling. A double-blind study was carried out in 3 subjects, all of whom showed diminished cold-stimulated histamine release after doxantrazole. Two of these showed clinical improvement. Doxantrazole had no effect on erythema due to intradermal histamine, but did suppress the erythematous reaction to intradermal injection of compound 48/80. Our results suggest that doxantrazole or related anti-allergic agents might be useful in the treatment of cold urticaria.

  17. Third International Symposium on Environmental Hydraulics with a Special Theme on Urban Fluid Dynamics

    NASA Technical Reports Server (NTRS)

    Boyer, Don

    2002-01-01

    This is to report on the use of the funds provided by NASA to support the 'Third International Symposium on Environmental Hydraulics with a Special Theme on Urban Fluid Dynamics'. The Symposium was held on the campus of Arizona State University in Tempe, Arizona, USA, from 5-8 December 2001. It proved to be a forum for the discussion of a wide range of applied and basic research being conducted in the general areas of water and air resources, with the latter focusing on air quality in urban areas associated with complex terrain. This aspect of the Symposium was highlighted by twelve invited papers given by distinguished international scientists and roughly three hundred contributed manuscripts. Owing primarily to the current international situation, roughly 20% of the authors canceled their plans to attend the Symposium; while this was unfortunate, the Symposium went ahead with the enthusiastic participation of more than 250 scientists from forty nations.

  18. Proceedings of the 2010 National Toxicology Program Satellite Symposium

    PubMed Central

    Adams, E. Terence; Auerbach, Scott; Blackshear, Pamela E.; Bradley, Alys; Gruebbel, Margarita M.; Little, Peter B.; Malarkey, David; Maronpot, Robert; McKay, Jennifer S.; Miller, Rodney A.; Moore, Rebecca R.; Morrison, James P.; Nyska, Abraham; Ramot, Yuval; Rao, Deepa; Suttie, Andrew; Wells, Monique Y.; Willson, Gabrielle A.; Elmore, Susan A.

    2011-01-01

    The 2010 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri,” was held in Chicago, Illinois, in advance of the scientific symposium sponsored jointly by the Society of Toxicologic Pathology (STP) and the International Federation of Societies of Toxicologic Pathologists (IFSTP). The goal of the annual NTP Symposium is to present current diagnostic pathology or nomenclature issues to the toxicologic pathology community. This article presents summaries of the speakers' presentations, including diagnostic or nomenclature issues that were presented, along with select images that were used for voting or discussion. Some topics covered during the symposium included a comparison of rat and mouse hepatocholangiocarcinoma, a comparison of cholangiofibrosis and cholangiocarcinoma in rats, a mixed pancreatic neoplasm with acinar and islet cell components, an unusual preputial gland tumor, renal hyaline glomerulopathy in rats and mice, eosinophilic substance in the nasal septum of mice, INHAND nomenclature for proliferative and nonproliferative lesions of the CNS/PNS, retinal gliosis in a rat, fibroadnexal hamartoma in rats, intramural plaque in a mouse, a treatment-related chloracne-like lesion in mice, and an overview of mouse ovarian tumors. PMID:21177527

  19. Topical Histamine Stimulates Repigmentation of Nonsegmental Vitiligo by a Receptor-Dependent Mechanism.

    PubMed

    Liu, Jun; Xu, Yan; Lin, Tzu-Kai; Lv, Chengzhi; Elias, Peter M; Man, Mao-Qiang

    2017-01-01

    Though vitiligo is a common depigmentary disorder, it still represents a substantial therapeutic challenge. Therapeutic options are limited in part due to its uncertain etiology. Because recent studies suggest that histamine stimulates melanogenesis in vitro, we determined here whether topical histamine stimulates repigmentation in patients with stable, nonsegmental vitiligo. A total of 23 otherwise normal volunteers with vitiligo, including 14 males and 9 females aged 6-59 years (mean age 29.2 ± 2.8), were enrolled in this study. 1% histamine in distilled water was applied to the lesions twice daily for 5 weeks, while comparable lesions, treated with distilled water alone, served as the controls. The melanin index was measured on the uninvolved and lesional skin sites before and after 5 weeks of treatments using the melanin/erythema probe connected to a Courage-Khazaka MPA5 (Cologne, Germany). Changes in epidermal permeability barrier were also assessed at the same time point. To determine whether histamine-induced repigmentation is receptor-dependent, both ears of C57BL/6J mice were treated topically with 5% cimetidine, a histamine type 2 receptor (H2r) antagonist, twice daily for 10 days. One hour after each cimetidine application, the right ear was treated topically with 10% histamine, while vehicle alone was applied to the left ear. Changes in melanin index were measured 24 h after the last application of histamine and vehicle as described in the human study. In patients with vitiligo treated with vehicle alone for 5 weeks, the melanin index remained unchanged, while topical histamine treatment increased the melanin index by 38% (p < 0.001 vs. both vehicle and pretreatment), which was paralleled by a >60% reduction in lesion surface area. Moreover, topical histamine accelerated permeability barrier recovery. No adverse events were observed following histamine applications. In mice, topical histamine significantly increased the melanin index, while topical co

  20. Sixth Goddard Conference on Mass Storage Systems and Technologies Held in Cooperation with the Fifteenth IEEE Symposium on Mass Storage Systems

    NASA Technical Reports Server (NTRS)

    Kobler, Benjamin (Editor); Hariharan, P. C. (Editor)

    1998-01-01

    This document contains copies of those technical papers received in time for publication prior to the Sixth Goddard Conference on Mass Storage Systems and Technologies which is being held in cooperation with the Fifteenth IEEE Symposium on Mass Storage Systems at the University of Maryland-University College Inn and Conference Center March 23-26, 1998. As one of an ongoing series, this Conference continues to provide a forum for discussion of issues relevant to the management of large volumes of data. The Conference encourages all interested organizations to discuss long term mass storage requirements and experiences in fielding solutions. Emphasis is on current and future practical solutions addressing issues in data management, storage systems and media, data acquisition, long term retention of data, and data distribution. This year's discussion topics include architecture, tape optimization, new technology, performance, standards, site reports, vendor solutions. Tutorials will be available on shared file systems, file system backups, data mining, and the dynamics of obsolescence.

  1. Happy, healthy, smart cities symposium in Knoxville, Tennessee : a TPCB peer exchange

    DOT National Transportation Integrated Search

    2017-07-01

    The Happy, Healthy, Smart Cities Symposium was a two-day event, held on March 29-30, 2016 in Knoxville, Tennessee, focused on exploring the impacts that transportation and land use decisions have on health, safety, and quality of life. The event was ...

  2. Laser induced damage in optical materials: ninth ASTM symposium.

    PubMed

    Glass, A J; Guenther, A H

    1978-08-01

    The Ninth Annual Symposium on Optical Materials for High Power Lasers (Boulder Damage Symposium) was held at the National Bureau of Standards in Boulder, Colorado, 4-6 October 1977. The symposium was under the auspices of ASTM Committee F-1, Subcommittee on Laser Standards, with the joint sponsorship of NBS, the Defense Advanced Research Project Agency, the Department of Energy (formerly ERDA), and the Office of Naval Research. About 185 scientists attended, including representatives of the United Kingdom, France, Canada, Australia, Union of South Africa, and the Soviet Union. The Symposium was divided into sessions concerning Laser Windows and Materials, Mirrors and Surfaces, Thin Films, Laser Glass and Glass Lasers, and Fundamental Mechanisms. As in previous years, the emphasis of the papers was directed toward new frontiers and new developments. Particular emphasis was given to materials for use from 10.6 microm to the uv region. Highlights included surface characterization, thin film-substrate boundaries, and advances in fundamental laser-matter threshold interactions and mechanisms. The scaling of damage thresholds with pulse duration, focal area, and wavelength were also discussed. Alexander J. Glass of Lawrence Livermore Laboratory and Arthur H. Guenther of the Air Force Weapons Laboratory were co-chairpersons. The Tenth Annual Symposium is scheduled for 12-14 September 1978 at the National Bureau of Standards, Boulder, Colorado.

  3. Nondestructive Testing and Evaluation of Wood—50 Years of Research: International Nondestructive Testing and Evaluation of Wood Symposium Series

    Treesearch

    Robert J. Ross; Xiping Wang

    2012-01-01

    The International Nondestructive Testing and Evaluation of Wood Symposium Series was initiated by Washington State University and the USDA Forest Products Laboratory (FPL) in 1963 with the convening of a symposium on the topic of nondestructive testing of wood at FPL. Including that meeting, 17 symposia have been held during the last 50 years at various sites around...

  4. Regional Symposium on Race, Language and Special Education. Proceedings Document.

    ERIC Educational Resources Information Center

    Markowitz, Joy, Ed.

    This symposium proceedings reports on the background, purpose, and implementation of meetings held on May 19-21, 1997 that focused on race, language, and special education. Participants from school districts in Connecticut, Massachusetts, New Jersey, New York, Rhode Island, and Vermont formed teams that included two or more of the following: local…

  5. EMRS Spring Meeting 2014 Symposium D: Phonons and fluctuations in low dimensional structures

    NASA Astrophysics Data System (ADS)

    2014-11-01

    The E-MRS 2014 Spring meeting, held from 26-30th May 2014 in Lille included the Symposium D entitled ''Phonons and Fluctuations in Low Dimensional Structures'', the first edition of its kind. The symposium was organised in response to the increasing interest in the study of phonons in the context of advances in condensed matter physics, electronics, experimental methods and theory and, in particular, the transfer of energy across atomic interfaces and the propagation of energy in the nm-scale. Steering heat by light or vice versa and examining nano-scale energy conversion (as in thermoelectricity and harvesting e.g. in biological systems) are two aspects that share the underlying science of energy processes across atomic interfaces and energy propagation in the nanoscale and or in confined systems. The nanometer scale defies several of the bulk relationships as confinement of electrons and phonons, locality and non-equilibrium become increasingly important. The propagation of phonons as energy carriers impacts not only heat transfer, but also the very concept and handling of temperature in non-equilibrium and highly localised conditions. Much of the needed progress depends on the materials studied and this symposium targeted the interface material aspects as well as the emerging concepts to advance in this field. The symposium had its origins in a series of meetings and seminars including: (1) the first Phonon Engineering Workshop, funded by Catalan Institute for Research and Advanced Studies (ICREA), the then MICINN, the CNRS, VTT, and several EU projects, held in Saint Feliu de Guixols (Girona, Spain) from 24th to 27th of May 2010 with 65 participants from Europe, the USA and Japan; (2) the first Phonons and Fluctuations workshop, held in Paris on 8th and 9th November 2010, supported by French, Spanish and Finnish national projects and EU projects, attended by about 50 researchers; (3) the second Phonon and Fluctuations workshop, held in Paris on 8th and 9th

  6. Investigations of magnesium, histamine and immunoglobulins dynamics in acute urticaria.

    PubMed

    Mureşan, D; Oană, A; Nicolae, I; Alecu, M; Moşescu, L; Benea, V; Flueraş, M

    1990-01-01

    In 42 urticaria patients, magnesium, histamine and IgE were dosed. Magnesium, IgE and histamine variations were followed in urticaria evolution, during acute phase and clinical remission. We noticed magnesium, histamine, IgE values variations depending on disease evolution and applied therapeutic scheme. Therefore: At disease starting point, histamine presented 3.5 times higher values than the normal ones. The value decreases following a curve which tends to reach normal values during clinical remission. At disease starting point, magnesium presented values under the inferior limit of the normal, 0.5 m mol/L respectively, as a mean. The value increases towards the normal limit during clinical remission. Immunoglobulins E follow a similar curve to histamine one, presenting 1,250 U/L values at the starting point, that, under medication, influence decrease between normal limits (800 U/L), during clinical remission. Analyzing the variations of biochemical parameters, the authors emphasize magnesium substitution treatment in urticaria.

  7. Kick-off symposium series to help New Ph.D.s is a success

    NASA Astrophysics Data System (ADS)

    Chernys, Michael; Roughan, Moninya

    The U.S. National Science Foundation (NSF) and the U.S. Office of Naval Research (ONR) recently sponsored the first of what is expected to be many symposia to be held every couple of years to help new scientists begin their research careers. The inaugural dissertation symposium, Physical Oceanography Dissertation Symposium I (PODS I), provided a forum for new Ph.D.s and doctoral candidates soon to receive their degrees in physical oceanography or a related field, to discuss science and forge future professional relationships. The next symposium is expected to be in October 2003, in Hawaii, in concert with the Dissertation Symposium for Chemical Oceanographers (DISCO); information to be posted at http://spars.aibs.org/pods/. Applications from prospective participants were sought internationally, with the sponsoring agencies and coordinators advertising by e-mail, through personal communication with established researchers, and by informing degree-granting institutions in the related fields.

  8. Proceedings of the High Consequence Operations Safety Symposium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1994-12-01

    Many organizations face high consequence safety situations where unwanted stimuli due to accidents, catastrophes, or inadvertent human actions can cause disasters. In order to improve interaction among such organizations and to build on each others` experience, preventive approaches, and assessment techniques, the High Consequence Operations Safety Symposium was held July 12--14, 1994 at Sandia National Laboratories, Albuquerque, New Mexico. The symposium was conceived by Dick Schwoebel, Director of the SNL Surety Assessment Center. Stan Spray, Manager of the SNL System Studies Department, planned strategy and made many of the decisions necessary to bring the concept to fruition on a shortmore » time scale. Angela Campos and about 60 people worked on the nearly limitless implementation and administrative details. The initial symposium (future symposia are planned) was structured around 21 plenary presentations in five methodology-oriented sessions, along with a welcome address, a keynote address, and a banquet address. Poster papers addressing the individual session themes were available before and after the plenary sessions and during breaks.« less

  9. The 14th Annual James L. Waters Symposium at Pittcon: Raman Spectroscopy

    ERIC Educational Resources Information Center

    Gardner, Charles W.

    2007-01-01

    Raman Spectroscopy was the main topic of the 14th Annual James L. Waters Symposium, which was held in March 2003 at Pittcon. The development of the enabling technologies that have made Raman spectroscopy a routine analysis tool in many laboratories worldwide is discussed.

  10. SYMPOSIUM ON NEW SCIENTIFIC RESEARCH RELATED TO THE HEALTH EFFECTS OF TRICHLOROETHYLENE

    EPA Science Inventory

    On February 26-27th, 2004, the National Center for Environmental Assessment (NCEA), a part of the U.S. Environmental Protection Agency's (EPA) Office of Research and Development, held a two-day public symposium on recently published scientific research related to the health effec...

  11. PREFACE: The 6th International Symposium on Measurement Techniques for Multiphase Flows

    NASA Astrophysics Data System (ADS)

    Okamoto, Koji; Murai, Yuichi

    2009-02-01

    Research on multi-phase flows is very important for industrial applications, including power stations, vehicles, engines, food processing, and so on. Also, from the environmental viewpoint, multi-phase flows need to be investigated to overcome global warming. Multi-phase flows originally have non-linear features because they are multi-phased. The interaction between the phases plays a very interesting role in the flows. The non-linear interaction causes the multi-phase flows to be very difficult to understand phenomena. The International Symposium on Measurement Techniques for Multi-phase Flows (ISMTMF) is a unique symposium. The target of the symposium is to exchange the state-of-the-art knowledge on the measurement techniques for non-linear multi-phase flows. Measurement technique is the key technology to understanding non-linear phenomena. The ISMTMF began in 1995 in Nanjing, China. The symposium has continuously been held every two or three years. The ISMTMF-2008 was held in Okinawa, Japan as the 6th symposium of ISMTMF on 15-17 December 2008. Okinawa has a long history as the Ryukyus Kingdom. China and Japan have had cultural and economic exchanges through Okinawa for more than 1000 years. Please enjoy Okinawa and experience its history to enhance our international communication. The present symposium was attended by 124 participants, the program included 107 contributions with 5 plenary lectures, 2 keynote lectures, and 100 oral regular paper presentations. The topics include, besides the ordinary measurement techniques for multiphase flows, acoustic and electric sensors, bubbles and microbubbles, computed tomography, gas-liquid interface, laser-imaging and PIV, oil/coal/drop and spray, solid and powder, spectral and multi-physics. This volume includes the presented papers at ISMTMF-2008. In addition to this volume, ten selected papers will be published in a special issue of Measurement Science and Technology. We would like to express special thanks to all

  12. Determination of histamine in milkfish stick implicated in food-borne poisoning.

    PubMed

    Lee, Yi-Chen; Kung, Hsien-Feng; Wu, Chien-Hui; Hsu, Hui-Mei; Chen, Hwi-Chang; Huang, Tzou-Chi; Tsai, Yung-Hsiang

    2016-01-01

    An incident of food-borne poisoning causing illness in 37 victims due to ingestion of fried fish sticks occurred in September 2014, in Tainan city, southern Taiwan. Leftovers of the victims' fried fish sticks and 16 other raw fish stick samples from retail stores were collected and tested to determine the occurrence of histamine and histamine-forming bacteria. Two suspected fried fish samples contained 86.6 mg/100 g and 235.0 mg/100 g histamine; levels that are greater than the potential hazard action level (50 mg/100 g) in most illness cases. Given the allergy-like symptoms of the victims and the high histamine content in the suspected fried fish samples, this food-borne poisoning was strongly suspected to be caused by histamine intoxication. Moreover, the fish species of suspected samples was identified as milkfish (Chanos chanos), using polymerase chain reaction direct sequence analysis. In addition, four of the 16 commercial raw milkfish stick samples (25%) had histamine levels greater than the US Food & Drug Administration guideline of 5.0 mg/100 g for scombroid fish and/or products. Ten histamine-producing bacterial strains, capable of producing 373-1261 ppm of histamine in trypticase soy broth supplemented with 1.0% L-histidine, were identified as Enterobacter aerogenes (4 strains), Enterobacter cloacae (1 strain), Morganella morganii (2 strains), Serratia marcescens (1 strain), Hafnia alvei (1 strain), and Raoultella orithinolytica (1 strain), by 16S ribosomal DNA sequencing with polymerase chain reaction amplification. Copyright © 2015. Published by Elsevier B.V.

  13. Inhibition of in vivo histamine metabolism in rats by foodborne and pharmacologic inhibitors of diamine oxidase, histamine N-methyltransferase, and monoamine oxidase

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hui, J.Y.; Taylor, S.L.

    When (/sup 14/C)histamine was administered orally to rats, an average of 80% of the administered radioactivity was recovered in the urine at the end of 24 hr. About 10% of the total dose was excreted via the feces. Analysis of 4-hr urine samples found imidazoleacetic acid to be the predominant metabolite (60.6%), with N tau-methylimidazoleacetic acid (8.6%), N tau-methylhistamine (7.3%), and N-acetylhistamine (4.5%) to be the minor metabolites. Histamine metabolism was inhibited by simultaneous oral administration of aminoguanidine, isoniazid, quinacrine, cadaverine, putrescine, tyramine, and beta-phenylethylamine. The administration of inhibitors resulted in an increased amount of unmetabolized histamine and a decreasedmore » amount of metabolites reaching the urine. Pharmacologic inhibitors were found to be more potent and have a longer duration of action than foodborne ones. The inhibitors could potentiate food poisoning caused by histamine by inhibiting its metabolism.« less

  14. Report of the 7th African Rotavirus Symposium, Cape Town, South Africa, 8th November 2012.

    PubMed

    Seheri, L M; Mwenda, J M; Page, N

    2014-11-12

    The 7th African Rotavirus Symposium was held in Cape Town, South Africa, on the 8th November 2012 as a Satellite Symposium at the First International African Vaccinology Conference. Over 150 delegates participated in this symposium including scientists, clinicians, health officials, policymakers and vaccine manufacturers from across Africa. Key topics discussed included rotavirus surveillance, rotavirus vaccine introduction, post rotavirus vaccine impact analysis and intussusception data and surveillance in Africa. The symposium provided early rotavirus vaccine adopter countries in Africa (South Africa, Ghana and Botswana) an opportunity to share up-to-date information on vaccine introduction, and allowed colleagues to share experiences in establishing routine rotavirus surveillance (Tanzania, Niger and Rwanda). Overall, the symposium highlighted the high burden of rotavirus in Africa, and the need to continue to strengthen efforts in preventing rotavirus diarrhoea in Africa. Copyright © 2014. Published by Elsevier Ltd.. All rights reserved.

  15. Genetics and the origin of species: the continuing synthesis a symposium in honor of Richard G. Harrison

    PubMed Central

    Grosberg, Richard K.; Rand, David M.; Normark, Benjamin B.

    2013-01-01

    This is a special issue of Genetica that has its origins in a symposium held in honor of Richard G. Harrison at Ithaca, New York on July 22–23. Former students of Rick Harrison organized the symposium and most of the speakers were former students, as well. The quality and breadth of the talks were a testament to Rick’s influence as a thinker, synthesizer, and mentor and it is only appropriate to reflect on Rick’s contributions to the fields of evolutionary ecology, systematics, and genetics in this preface to the symposium articles. PMID:21152955

  16. Science and stewardship to protect and sustain wilderness values: Tenth World Wilderness Congress symposium; 2013, 4-10 October, Salamanca, Spain

    Treesearch

    Alan Watson; Stephen Carver; Zdenka Krenova; Brooke McBride

    2015-01-01

    The Tenth World Wilderness Congress (WILD10) met in Salamanca, Spain in 2013. The symposium on science and stewardship to protect and sustain wilderness values was the largest of multiple symposia held in conjunction with the Congress. This symposium was organized and sponsored by the Aldo Leopold Wilderness Research Institute, the Wildland Research Institute of the...

  17. SPECIAL ISSUE VETERINARY IMMUNOLOGY IMMUNOPATHOLOGY: PROCEEDINGS 8TH INTERNATIONAL VETERINARY IMMUNOLOGY SYMPOSIUM

    USDA-ARS?s Scientific Manuscript database

    This is the Special Issue of Vet. Immunol. Immunopathol. that summarizes the 8th International Veterinary Immunology Symposium (8 th IVIS) held August 15th-19th, 2007, in Ouro Preto, Brazil. The 8 th IVIS highlighted the importance of veterinary immunology for animal health, vaccinology, reproducti...

  18. Proceedings of the Symposium on the Management of Longleaf Pine

    Treesearch

    Robert S. Farrar; [Editor

    1989-01-01

    The symposium on the management of longleaf pine leading to these proceedings was held on April 4 through 6, 1989, in Long Beach, MS, at the Gulf Park Conference Center of the University of Southern Mississippi. This conference was attended by approximately 170 land managers, wildlife managers, researchers, educators, students, and others interested in longleaf pine...

  19. NCI RNA Biology 2017 symposium recap | Center for Cancer Research

    Cancer.gov

    The recent discovery of new classes of RNAs and the demonstration that alterations in RNA metabolism underlie numerous human cancers have resulted in enormous interest among CCR investigators in RNA biology. In order to share the latest research in this exciting field, the CCR Initiative in RNA Biology held its second international symposium April 23-24, 2017, in Natcher

  20. Histamine-binding capacities of different natural zeolites: a comparative study.

    PubMed

    Selvam, Thangaraj; Schwieger, Wilhelm; Dathe, Wilfried

    2018-06-07

    Two different natural zeolites from Cuba and Mexico, which are already being used as contemporaneous drugs or dietary supplements in Germany and Mexico, respectively, are applied in a comparative study of their histamine-binding capacities as a function of their particle sizes. The zeolites are characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM) and N 2 -sorption measurements (BET surface areas). The Cuban zeolite contains clinoptilolite and mordenite as major phases (78% zeolite), whereas the Mexican one contains only clinoptilolite (65% zeolite). Both zeolites are apparently free from fibrous materials according to SEM. Both zeolites adsorb significant amount of histamine under the experimental conditions. Nevertheless, the results showed that the histamine-binding capacity of the Cuban zeolite is higher than the Mexican one and the smaller the particle size of zeolite, the higher the histamine-binding capacity. This difference could be due to the variation in their mineralogical compositions resulting in varied BET surface areas. Thus, the high histamine-binding capacities of Cuban zeolites seem to be due at least partly to the presence of the large-pore zeolite mordenite, providing high total pore volumes, which will be discussed in detail. For the first time, we have shown that the mineralogical compositions of natural zeolites and their particle sizes play a key role in binding histamine, which is one of the most important regulators in human physiology.

  1. Punishment and the potential for negative reinforcement with histamine injection.

    PubMed

    Mayer, Paulo César Morales; de Carvalho Neto, Marcus Bentes; Katz, Jonathan L

    2018-03-01

    The present study examined punishment of responding with histamine injection, and its potential to generate avoidance of punishment. Sprague-Dawley rats were trained under concurrent schedules in which responses on one lever (the punishment lever) produced food under a variable-interval schedule, and under some conditions intermittent injections of histamine, which suppressed behavior. Responses on a second (avoidance) lever prevented histamine injections scheduled on the punishment lever. After stabilization of punished responding, a variable-interval 15-s schedule of cancellation of histamine (avoidance) was added for responding on the second/avoidance lever, without subsequent acquisition of responding on that lever. Progressive decreases in the length of the punishment variable-interval schedule increased suppression on the punishment lever without increases in response rates on the avoidance lever. Exchanging contingencies on the levers ensured that response rates on the avoidance lever were sufficiently high to decrease the histamine injection frequency; nonetheless response rates on the avoidance lever decreased over subsequent sessions. Under no condition was responding maintained on the avoidance lever despite continued punishing effectiveness of histamine throughout. The present results suggest that avoidance conditioning is not a necessary condition for effective punishment, and confirm the importance of empirical rather than presumed categorization of behavioral effects of stimulus events. Published 2018. This article is a U.S. Government work and is in the public domain in the USA.

  2. Characteristics of recombinantly expressed rat and human histamine H3 receptors.

    PubMed

    Wulff, Birgitte S; Hastrup, Sven; Rimvall, Karin

    2002-10-18

    Human and rat histamine H(3) receptors were recombinantly expressed and characterized using receptor binding and a functional cAMP assay. Seven of nine agonists had similar affinities and potencies at the rat and human histamine H(3) receptor. S-alpha-methylhistamine had a significantly higher affinity and potency at the human than rat receptor, and for 4-[(1R*,2R*)-2-(5,5-dimethyl-1-hexynyl)cyclopropyl]-1H-imidazole (Perceptin) the preference was the reverse. Only two of six antagonists had similar affinities and potencies at the human and the rat histamine H(3) receptor. Ciproxifan, thioperamide and (1R*,2R*)-trans-2-imidazol-4 ylcyclopropyl) (cyclohexylmethoxy) carboxamide (GT2394) had significantly higher affinities and potencies at the rat than at the human histamine H(3) receptor, while for N-(4-chlorobenzyl)-N-(7-pyrrolodin-1-ylheptyl)guanidine (JB98064) the preference was the reverse. All antagonists also showed potent inverse agonism properties. Iodoproxyfan, Perceptin, proxyfan and GR175737, compounds previously described as histamine H(3) receptor antagonists, acted as full or partial agonists at both the rat and the human histamine H(3) receptor. Copyright 2002 Elsevier Science B.V.

  3. Histamine as an emergent indoor contaminant: Accumulation and persistence in bed bug infested homes.

    PubMed

    DeVries, Zachary C; Santangelo, Richard G; Barbarin, Alexis M; Schal, Coby

    2018-01-01

    Histamine is used in bronchial and dermal provocation, but it is rarely considered an environmental risk factor in allergic disease. Because bed bugs defecate large amounts of histamine as a component of their aggregation pheromone, we sought to determine if histamine accumulates in household dust in bed bug infested homes, and the effects of bed bug eradication with spatial heat on histamine levels in dust. We collected dust in homes and analyzed for histamine before, and up to three months after bed bug eradication. Histamine levels in bed bug infested homes were remarkably high (mean = 54.6±18.9 μg/100 mg of sieved household dust) and significantly higher than in control homes not infested with bed bugs (mean < 2.5±1.9 μg/100 mg of sieved household dust). Heat treatments that eradicated the bed bug infestations failed to reduce histamine levels, even three months after treatment. We report a clear association between histamine levels in household dust and bed bug infestations. The high concentrations, persistence, and proximity to humans during sleep suggest that bed bug-produced histamine may represent an emergent contaminant and pose a serious health risk in the indoor environment.

  4. Proceedings of the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. Volume 1

    NASA Technical Reports Server (NTRS)

    Bigelow, Catherine A. (Compiler)

    1997-01-01

    This publication contains the fifty-two technical papers presented at the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. The symposium, hosted by the FAA Center of Excellence for Computational Modeling of Aircraft Structures at Georgia Institute of Technology, was held to disseminate information on recent developments in advanced technologies to extend the life of high-time aircraft and design longer-life aircraft. Affiliations of the participants included 33% from government agencies and laboratories, 19% from academia, and 48% from industry; in all 240 people were in attendance. Technical papers were selected for presentation at the symposium, after a review of extended abstracts received by the Organizing Committee from a general call for papers.

  5. Proceedings of the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. Volume 2

    NASA Technical Reports Server (NTRS)

    Bigelow, Catherine A. (Compiler)

    1997-01-01

    This publication contains the fifty-two technical papers presented at the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. The symposium, hosted by the FAA Center of Excellence for Computational Modeling of Aircraft Structures at Georgia Institute of Technology, was held to disseminate information on recent developments in advanced technologies to extend the life of high-time aircraft and design longer-life aircraft. Affiliations of the participants included 33% from government agencies and laboratories, 19% from academia, and 48% from industry; in all 240 people were in attendance. Technical papers were selected for presentation at the symposium, after a review of extended abstracts received by the Organizing Committee from a general call for papers.

  6. Introduction to the IEEE International Symposium on Applications of Ferroelectrics and International Symposium on Piezoresponse Force Microscopy and Nanoscale Phenomena in Polar Materials.

    PubMed

    Ye, Zuo-Guang; Tan, Xiaoli; Bokov, Alexei A

    2012-09-01

    The 20th IEEE International Symposium on Applications of Ferroelectrics (ISAF) was held on July 24-27, 2011, in Vancouver, British Columbia, Canada, jointly with the International Symposium on Piezoresponse Force Microscopy and Nanoscale Phenomena in Polar Materials (PFM). Over a period of four days, approximately 400 scientists, engineers, and students from around the world presented their work and discussed the latest developments in the field of ferroelectrics, related materials, and their applications. It is particularly encouraging to see that a large number of students (115) were attracted to the joint conference and presented high-quality research works. This trend is not only important to this conference series, but more importantly, it is vital to the future of the ferroelectrics field.

  7. High-performance liquid chromatographic determination of histamine in biological samples: the cerebrospinal fluid challenge--a review.

    PubMed

    Wang, Zhaopin; Wu, Juanli; Wu, Shihua; Bao, Aimin

    2013-04-24

    Histamine, a neurotransmitter crucially involved in a number of basic physiological functions, undergoes changes in neuropsychiatric disorders. Detection of histamine in biological samples such as cerebrospinal fluid (CSF) is thus of clinical importance. The most commonly used method for measuring histamine levels is high performance liquid chromatography (HPLC). However, factors such as very low levels of histamine, the even lower CSF-histamine and CSF-histamine metabolite levels, especially in certain neuropsychiatric diseases, rapid formation of histamine metabolites, and other confounding elements during sample collection, make analysis of CSF-histamine and CSF-histamine metabolites a challenging task. Nonetheless, this challenge can be met, not only with respect to HPLC separation column, derivative reagent, and detector, but also in terms of optimizing the CSF sample collection. This review aims to provide a general insight into the quantitative analyses of histamine in biological samples, with an emphasis on HPLC instruments, methods, and hyphenated techniques, with the aim of promoting the development of an optimal and practical protocol for the determination of CSF-histamine and/or CSF-histamine metabolites. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. Science and stewardship to protect and sustain wilderness values: Ninth World Wilderness Congress symposium; November 6-13, 2009; Merida, Yucatan, Mexico

    Treesearch

    Alan Watson; Joaquin Murrieta-Saldivar; Brooke McBride

    2011-01-01

    The Ninth World Wilderness Congress (WILD9) met in Merida, Yucatan, Mexico in 2009. The symposium on science and stewardship to protect and sustain wilderness values was the largest of multiple symposia held in conjunction with the Congress. The papers contained in this proceedings were generated at this symposium or submitted by the author or authors for consideration...

  9. Proceedings of the 2016 National Toxicology Program Satellite Symposium.

    PubMed

    Elmore, Susan A; Chen, Vivian S; Hayes-Bouknight, Schantel; Hoane, Jessica S; Janardhan, Kyathanahalli; Kooistra, Linda H; Nolte, Thomas; Szabo, Kathleen A; Willson, Gabrielle A; Wolf, Jeffrey C; Malarkey, David E

    2017-01-01

    The 2016 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri" was held in San Diego, CA, at the Society of Toxicologic Pathology's (STP) 35th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers' talks, along with select images that were used by the audience for voting and discussion. Some lesions and topics covered during the symposium included malignant glioma and histiocytic sarcoma in the rodent brain; a new statistical method designed for histopathology data evaluation; uterine stromal/glandular polyp in a rat; malignant plasma cell tumor in a mouse brain; Schwann cell proliferative lesions in rat hearts; axillary schwannoma in a cat; necrosis and granulomatous inflammation in a rat brain; adenoma/carcinoma in a rat adrenal gland; hepatocyte maturation defect and liver/spleen hematopoietic defects in an embryonic mouse; distinguishing malignant glioma, malignant mixed glioma, and malignant oligodendroglioma in the rat; comparison of mammary gland whole mounts and histopathology from mice; and discussion of the International Harmonization of Nomenclature and Diagnostic Criteria collaborations.

  10. Symposium Commemorating the 25th Anniversary of the Discovery of Mendelevium

    DOE R&D Accomplishments Database

    Seaborg, G. T. (ed.)

    1980-03-28

    The Symposium honoring the 25th Anniversary of the discovery of mendelevium was held at the Lawrence Berkeley Laboratory on March 28, 1980. The following three papers were presented: Chemical Properties of Mendelevium; Nuclear Properties of Mendelevium; and Radioactive Decay of Md Isotopes. Besides these papers there were introductory remarks, reminiscences, and concluding remarks.

  11. Histamine as an emergent indoor contaminant: Accumulation and persistence in bed bug infested homes

    PubMed Central

    Santangelo, Richard G.; Barbarin, Alexis M.; Schal, Coby

    2018-01-01

    Histamine is used in bronchial and dermal provocation, but it is rarely considered an environmental risk factor in allergic disease. Because bed bugs defecate large amounts of histamine as a component of their aggregation pheromone, we sought to determine if histamine accumulates in household dust in bed bug infested homes, and the effects of bed bug eradication with spatial heat on histamine levels in dust. We collected dust in homes and analyzed for histamine before, and up to three months after bed bug eradication. Histamine levels in bed bug infested homes were remarkably high (mean = 54.6±18.9 μg/100 mg of sieved household dust) and significantly higher than in control homes not infested with bed bugs (mean < 2.5±1.9 μg/100 mg of sieved household dust). Heat treatments that eradicated the bed bug infestations failed to reduce histamine levels, even three months after treatment. We report a clear association between histamine levels in household dust and bed bug infestations. The high concentrations, persistence, and proximity to humans during sleep suggest that bed bug-produced histamine may represent an emergent contaminant and pose a serious health risk in the indoor environment. PMID:29432483

  12. Histamine receptors in human detrusor smooth muscle cells: physiological properties and immunohistochemical representation of subtypes.

    PubMed

    Neuhaus, Jochen; Weimann, Annett; Stolzenburg, Jens-Uwe; Dawood, Waled; Schwalenberg, Thilo; Dorschner, Wolfgang

    2006-06-01

    The potent inflammatory mediator histamine is released from activated mast cells in interstitial cystitis (IC). Here, we report on the histamine receptor subtypes involved in the intracellular calcium response of cultured smooth muscle cells (cSMC). Fura-2 was used to monitor the calcium response in cSMC, cultured from human detrusor biopsies. The distribution of histamine receptor subtypes was addressed by immunocytochemistry in situ and in vitro. Histamine stimulated a maximum of 92% of the cells (n=335), being more effective than carbachol (70%, n=920). HTMT (H1R-agonist), dimaprit (H2R) and MTH (H3R) lead to significant lower numbers of reacting cells (60, 48 and 54%). Histamine receptor immunoreactivity (H1R, H2R, H3R, H4R) was found in situ and in vitro. Histamine-induced calcium increase is mediated by distinct histamine receptors. Thus, pre-therapeutic evaluation of histamine receptor expression in IC patients may help to optimize therapy by using a patient-specific cocktail of subtype-specific histamine receptor antagonists.

  13. Mosquito vector biology and control in Latin America - A 25th Symposium

    USDA-ARS?s Scientific Manuscript database

    The 25th Annual Latin American Symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 81st Annual Meeting in New Orleans, LA, in March 2015. The principal objective, for the previous 24 symposia, was to promote participation in the AMCA by vector control spec...

  14. Mosquito vector biology and control in Latin America - a 24th symposium

    USDA-ARS?s Scientific Manuscript database

    The 24th Annual Latin American Symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 80th Annual Meeting in Seattle, WA in February 2014. The principal objective, as for the previous 23 symposia, was to promote participation in the AMCA by vector control spe...

  15. MOSQUITO VECTOR CONTROL AND BIOLOGY IN LATIN AMERICA- An 18TH SYMPOSIUM

    USDA-ARS?s Scientific Manuscript database

    The 18th Annual Latin American symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 74th Annual Meeting in Sparks, NV, in March 2008. The principal objective, as for the previous 17 symposia, was to promote participation in the AMCA by vector control speci...

  16. February NICBR Symposium Highlights Careers in Science | Poster

    Cancer.gov

    Poster Staff The first National Interagency Confederation for Biological Research (NICBR) Exploring Careers in a Scientific Environment Symposium was held on Feb. 18 at the Advanced Technology Research Facility. The event drew more than 70 Frederick County public school teachers, who learned about the wide range of biomedical research being conducted by scientists in the NICBR agencies, as well as the variety of opportunities for students interested in pursuing careers in science and/or technology.

  17. International Symposium on Magnetic Suspension Technology, Part 2

    NASA Technical Reports Server (NTRS)

    Groom, Nelson J. (Editor); Britcher, Colin P. (Editor)

    1992-01-01

    In order to examine the state of technology of all areas of magnetic suspension and to review related recent developments in sensors and controls approaches, superconducting magnet technology, and design/implementation practices, a symposium was held. The proceedings are presented. The sessions covered the areas of bearings, sensors and controls, microgravity and vibration isolation, superconductivity, manufacturing applications, wind tunnel magnetic suspension systems, magnetically levitated trains (MAGLEV), space applications, and large gap magnetic suspension systems.

  18. NCI RNA Biology 2017 symposium recap | Center for Cancer Research

    Cancer.gov

    The recent discovery of new classes of RNAs and the demonstration that alterations in RNA metabolism underlie numerous human cancers have resulted in enormous interest among CCR investigators in RNA biology. In order to share the latest research in this exciting field, the CCR Initiative in RNA Biology held its second international symposium April 23-24, 2017, in Natcher Auditorium. Learn more...

  19. Second ISCB Latin American Student Council Symposium (LA-SCS) 2016

    PubMed Central

    Monzon, Alexander Miguel; Hasenahuer, Marcia A.; Mancini, Estefanía; Coimbra, Nilson; Cravero, Fiorella; Cáceres-Molina, Javier; Ramírez-Sarmiento, César A.; Palopoli, Nicolas; Meysman, Pieter; Parra, R. Gonzalo

    2017-01-01

    This report summarizes the scientific content and activities of the second edition of the Latin American Symposium (LA-SCS), organized by the Student Council (SC) of the International Society for Computational Biology (ISCB), held in conjunction with the Fourth Latin American conference from the International Society for Computational Biology (ISCB-LA 2016) in Buenos Aires, Argentina, on November 19, 2016. PMID:28928937

  20. Highlights from the Eighth International Society for Computational Biology (ISCB) Student Council Symposium 2012

    PubMed Central

    2012-01-01

    The report summarizes the scientific content of the annual symposium organized by the Student Council of the International Society for Computational Biology (ISCB) held in conjunction with the Intelligent Systems for Molecular Biology (ISMB) conference in Long Beach, California on July 13, 2012.

  1. International Symposium on Advanced Materials (ISAM 2013)

    NASA Astrophysics Data System (ADS)

    2014-06-01

    This proceeding is a compilation of peer reviewed papers presented at the 13th International Symposium on Advanced Materials (ISAM 2013) held from September 23-27, 2013, at Islamabad, Pakistan. In my capacity as ISAM-2013 Secretary, I feel honoured that the symposium has ended on a positive note. The ever increasing changes and intricacies that characterize modern industry necessitate a growing demand for technical information on advanced materials. ISAM and other similar forums serve to fulfill this need. The five day deliberations of ISAM 2013, consisted of 19 technical sessions and 2 poster sessions. In all, 277 papers were presented, inclusive of 80 contributory, invited and oral presentations. The symposium also hosted panel discussions led by renowned scientists and eminent researchers from foreign as well as local institutes. The ultimate aim of this proceeding is to record in writing the new findings in the field of advanced materials. I hope that the technical data available in this publication proves valuable to young scientists and researchers working in this area of science. At the same time, I wish to acknowledge Institute of Physics (IOP) Publishing UK, for accepting the research papers from ISAM-2013 for publication in the IOP Conference Series: Materials Science and Engineering. The proceeding will be available on the IOP website as an online open access document. I am profoundly thankful to the Symposium Chairman for his steadfast support and valuable guidance without which ISAM 2013 could not have been the mega event that it turned out to be. My gratitude to all our distinguished participants, session chairs/co-chairs, and reviewers for their active role in the symposium. I appreciate the entire organizing committee for the zest and ardor with which each committee fulfilled its obligations to ISAM. Last yet not the least, my thankfulness goes to all our sponsors for wilfully financing the event. Dr. Sara Qaisar Symposium Secretary Further

  2. Non-Volatile Memory Technology Symposium 2001: Proceedings

    NASA Technical Reports Server (NTRS)

    Aranki, Nazeeh; Daud, Taher; Strauss, Karl

    2001-01-01

    This publication contains the proceedings for the Non-Volatile Memory Technology Symposium 2001 that was held on November 7-8, 2001 in San Diego, CA. The proceedings contains a a wide range of papers that cover current and new memory technologies including Flash memories, Magnetic Random Access Memories (MRAM and GMRAM), Ferro-electric RAM (FeRAM), and Chalcogenide RAM (CRAM). The papers presented in the proceedings address the use of these technologies for space applications as well as radiation effects and packaging issues.

  3. Symposium on General Linear Model Approach to the Analysis of Experimental Data in Educational Research (Athens, Georgia, June 29-July 1, 1967). Final Report.

    ERIC Educational Resources Information Center

    Bashaw, W. L., Ed.; Findley, Warren G., Ed.

    This volume contains the five major addresses and subsequent discussion from the Symposium on the General Linear Models Approach to the Analysis of Experimental Data in Educational Research, which was held in 1967 in Athens, Georgia. The symposium was designed to produce systematic information, including new methodology, for dissemination to the…

  4. Science and stewardship to protect and sustain wilderness values: Seventh World Wilderness Congress symposium; 2001 November 2-8; Port Elizabeth, South Africa

    Treesearch

    Alan Watson; Janet Sproull

    2003-01-01

    The Seventh World Wilderness Congress met in Port Elizabeth, South Africa, in 2001. The symposium on science and stewardship to protect and sustain wilderness values was one of several symposia held in conjunction with the Congress. The papers contained in this proceedings were presented at this symposium and cover seven topics: state-of-knowledge on protected areas...

  5. [Effect of nociceptin on histamine and serotonin release in the central nervous system].

    PubMed

    Gyenge, Melinda; Hantos, Mónika; Laufer, Rudolf; Tekes, Korniléa

    2006-01-01

    Role in pain sensation of both nociceptin (NC), the bioactive heptadecapeptide sequence of preproorphaninFQ and of histamine has been widely evidenced in the central nervous system (CNS). In the current series of experiments effect of intracerebroventricularly (i.c.v.) administered NC (5.5 nmol/rat) on histamine and serotonin levels in blood plasma, CSF and brain areas (hypothalamus and hippocampus) was studies and compared to the effect of the mast cell degranulator Compound 48/80(100microg/kg, i.c.v.) and the neuroactive peptide Substance P (50nmol/rat, i.c.v.). It was found that all the three compounds increased the histamine level in the CNS, however their activity concerning the mast cell-, and neuronal histamine release is different. NC could release histamine from both the mast cells and the neurons and it decreased CNS serotonin levels. Substance P was found the most potent in increasing CNS histamine levels. Compound 48/80 treatment resulted in elevated histamine levels both in the CNS and blood plasma. It is concluded that the histamine releasing effects of i.c.v. administered NC and SP are limited to the CNS, but in the effect of Compound 48/80 its blood-brain barrier impairing activity is also involved. Data also demonstrate that NC has significant effect on both the histaminergic and serotonergic neurotransmission in the CNS.

  6. Children, nature, and the urban environment: proceedings of a symposium-fair

    Treesearch

    Northeastern Forest Experiment Station

    1977-01-01

    A report on the symposium-fair held 19-23 May, 1975 at the C. H. Marvin Center, the George Washington University, Washington, D.C., containing 33 papers. Sections are devoted to defining the role of natural environments and human development, research on urban children and the natural environment, and community and institutional response to fostering desirable...

  7. Symposium on "Shut Out Youth" (Strasbourg, France, October 25-30, 1987).

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France).

    Many aspects of social policy affect the lives of shut out youth in Europe. The purpose of a symposium held at the European Youth Center (Strasbourg, France) was to draw attention to these issues and recommend ways to coordinate the social policies that affect the well-being of youth. The relevance of current policies was assessed in local,…

  8. 8th Annual Glycoscience Symposium: Integrating Models of Plant Cell Wall Structure, Biosynthesis and Assembly

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Azadi, Paratoo

    2015-09-24

    The Complex Carbohydrate Research Center (CCRC) of the University of Georgia holds a symposium yearly that highlights a broad range of carbohydrate research topics. The 8th Annual Georgia Glycoscience Symposium entitled “Integrating Models of Plant Cell Wall Structure, Biosynthesis and Assembly” was held on April 7, 2014 at the CCRC. The focus of symposium was on the role of glycans in plant cell wall structure and synthesis. The goal was to have world leaders in conjunction with graduate students, postdoctoral fellows and research scientists to propose the newest plant cell wall models. The symposium program closely followed the DOE’s missionmore » and was specifically designed to highlight chemical and biochemical structures and processes important for the formation and modification of renewable plant cell walls which serve as the basis for biomaterial and biofuels. The symposium was attended by both senior investigators in the field as well as students including a total attendance of 103, which included 80 faculty/research scientists, 11 graduate students and 12 Postdoctoral students.« less

  9. PREFACE: International Symposium on Molecular Conductors: Novel Functions of Molecular Conductors under Extreme Conditions (ISMC 2008)

    NASA Astrophysics Data System (ADS)

    Takahashi, Toshihiro; Suzumura, Yoshikazu

    2008-02-01

    The International Symposium on Molecular Conductors 2008 (ISMC2008) was held as the second international symposium of the project entitled `Novel Functions of Molecular Conductors under Extreme Conditions', which was supported by the Grant-in-aid for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science and Technology in Japan. The project lasted from September 2003 to March 2008, and was completed by this symposium held at Okazaki Conference Center, Institute for Molecular Science, Okazaki, Japan (23-25 July 2008), which about 100 scientists attended. During the symposium, five project teams gave summary talks and exciting talks were given on the topics developed recently not only by the members of the project but also by other scientists including invited speakers from abroad, who are doing active research on molecular conductors. It is expected that papers presented in the symposium will give valuable hints for the next step in the research of this field. Therefore the organizers of this symposium decided to publish this proceedings in order to demonstrate these activities, not only for the local community of the project, but also for the broad society of international scientists who are interested in molecular conductors. The editors, who are also the organizers of this symposium, believe that this proceedings provides a significant and relevant contribution to the field of molecular conductors since it is the first time we have published such a proceedings as an electronic journal. We note that all papers published in this volume of Journal of Physics: Conference Series have been peer reviewed by expert referees. Editors made every effort to satisfy the criterion of a proceedings journal published by IOP Publishing. Toshihiro Takahashi and Yoshikazu Suzumura Editors: Toshihiro Takahashi (Gakushuin University) (Chairman) Kazushi Kanoda (University of Tokyo) Seiichi Kagoshima (University of Tokyo) Takehiko Mori (Tokyo

  10. MOSQUITO VECTOR CONTROL AND BIOLOGY IN LATIN AMERICA - A 19TH SYMPOSIUM

    USDA-ARS?s Scientific Manuscript database

    The 19th Annual Latin American symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 75th Annual Meeting in New Orleans, LA, in April 2009. The principal objective, as for the previous 18 symposia, was to promote participation in the AMCA by vector control s...

  11. Proceedings of the symposium on dynamics and management of Mediterranean-type ecosystems

    Treesearch

    C. Eugene Conrad; Walter C. Oechel

    1982-01-01

    The symposium, held at San Diego State University, provided information about the Mediterranean-type ecosystems found throughout the world. In the papers, and in brief summeries of poster displays, both researchers and managers addressed concerns relating to vegetation, fauna, soils, hydrology, fire, and planning. A Review and Follow-up section presents general...

  12. Discussing the Issues: A Report on the 2013 Ivies + Access Services Symposium

    ERIC Educational Resources Information Center

    Wilson, Andrew M.

    2014-01-01

    As access services emerges as a discrete discipline within the field of librarianship, opportunities for access services librarians to meet and discuss the issues facing today's libraries continue to grow. One annual meeting that has attracted less attention over the years is the Ivies + Access Services Symposium. Held at various member…

  13. Transcript of the Joint FAA/Industry Symposium on Level B Airplane simulator aeromodel validation requirements

    DOT National Transportation Integrated Search

    1996-03-13

    "This is the transcript of the Joint FAA/Industry Symposium on Level B Airplane Simulator Aeromodel Validation Requirements held on March 13-14, 1996, at the Washington Dulles Airport Hilton. The purpose of the meeting was to discuss the aeromodeling...

  14. TASK Channels on Basal Forebrain Cholinergic Neurons Modulate Electrocortical Signatures of Arousal by Histamine

    PubMed Central

    Vu, Michael T.; Du, Guizhi; Bayliss, Douglas A.

    2015-01-01

    Basal forebrain cholinergic neurons are the main source of cortical acetylcholine, and their activation by histamine elicits cortical arousal. TWIK-like acid-sensitive K+ (TASK) channels modulate neuronal excitability and are expressed on basal forebrain cholinergic neurons, but the role of TASK channels in the histamine-basal forebrain cholinergic arousal circuit is unknown. We first expressed TASK channel subunits and histamine Type 1 receptors in HEK cells. Application of histamine in vitro inhibited the acid-sensitive K+ current, indicating a functionally coupled signaling mechanism. We then studied the role of TASK channels in modulating electrocortical activity in vivo using freely behaving wild-type (n = 12) and ChAT-Cre:TASKf/f mice (n = 12), the latter lacking TASK-1/3 channels on cholinergic neurons. TASK channel deletion on cholinergic neurons significantly altered endogenous electroencephalogram oscillations in multiple frequency bands. We then identified the effect of TASK channel deletion during microperfusion of histamine into the basal forebrain. In non-rapid eye movement sleep, TASK channel deletion on cholinergic neurons significantly attenuated the histamine-induced increase in 30–50 Hz activity, consistent with TASK channels contributing to histamine action on basal forebrain cholinergic neurons. In contrast, during active wakefulness, histamine significantly increased 30–50 Hz activity in ChAT-Cre:TASKf/f mice but not wild-type mice, showing that the histamine response depended upon the prevailing cortical arousal state. In summary, we identify TASK channel modulation in response to histamine receptor activation in vitro, as well as a role of TASK channels on cholinergic neurons in modulating endogenous oscillations in the electroencephalogram and the electrocortical response to histamine at the basal forebrain in vivo. SIGNIFICANCE STATEMENT Attentive states and cognitive function are associated with the generation of γ EEG activity

  15. Sanibel Symposium in the Petascale-Exascale Computational Era

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cheng, Hai-Ping

    The 56 th Sanibel Symposium was held February 14-19 2016 at the King and Prince Hotel, St. Simons Island, GA. It successfully brought quantum chemists and chemical and condensed matter physicists together in presentations, posters, and informal discussions bridging those two communities. The Symposium has had a significant role in preparing generations of quantum theorists. As computational potency and algorithmic sophistication have grown, the Symposium has evolved to emphasize more heavily computationally oriented method development in chemistry and materials physics, including nanoscience, complex molecular phenomena, and even bio-molecular methods and problems. Given this context, the 56 th Sanibel meeting systematicallymore » and deliberately had sessions focused on exascale computation. A selection of outstanding theoretical problems that need serious attention was included. Five invited sessions, two contributed sessions (hot topics), and a poster session were organized with the exascale theme. This was a historic milestone in the evolution of the Symposia. Just as years ago linear algebra, perturbation theory, density matrices, and band-structure methods dominated early Sanibel Symposia, the exascale sessions of the 56 thmeeting contributed a transformative influence to add structure and strength to the computational physical science community in an unprecedented way. A copy of the full program of the 56 th Symposium is attached. The exascale sessions were Linear Scaling, Non-Adabatic Dynamics, Interpretive Theory and Models, Computation, Software, and Algorithms, and Quantum Monte Carlo. The Symposium Proceedings will be published in Molecular Physics (2017). Note that the Sanibel proceedings from 2015 and 2014 were published as Molecular Physics vol. 114, issue 3-4 (2016) and vol. 113, issue 3-4 (2015) respectively.« less

  16. Proceedings of the symposium on research and management of annosus root disease (Heterobasidion annosum) in western North America; April 18-21, 1989; Monterey, CA.

    Treesearch

    William J. Otrosina; Robert F. Scharpf

    1989-01-01

    The proceedings is a collection of papers presented at the Symposium on Research and Management of Annosus Root Disease (Heterobasidion annosum) in Western North America held in Monterey, California, April 18-21, 1989. As the first symposium dealing with this subject in the western United States, the papers presented address current research and...

  17. Rotavirus landscape in Africa-Towards prevention and control: A report of the 8th African rotavirus symposium, Livingstone, Zambia.

    PubMed

    Rudd, Cheryl; Mwenda, Jason; Chilengi, Roma

    2015-06-26

    The 8th African Rotavirus Symposium was held in Livingstone, Zambia from the 12-13 June 2014. Over 130 delegates from 35 countries - 28 from African nations - participated in this symposium, which included scientists, clinicians, immunisation managers, public health officials, policymakers and vaccine manufacturers. The theme for the symposium was Rotavirus Landscape in Africa-Towards Prevention and Control. At the time of the symposium, a total of 21 African countries had introduced the rotavirus vaccine into their national immunisation schedules. This meeting was particularly timely and relevant to review early data on vaccine adoption and impact from these countries. The concluding panel discussion proposed several recommendations for areas of focus moving forward in rotavirus advocacy and research. Copyright © 2015. Published by Elsevier Ltd.. All rights reserved.

  18. PROCEEDINGS: SYMPOSIUM ON FLUE GAS DESULFURIZATION HELD AT LAS VEGAS, NEVADA, MARCH 1979; VOLUME II

    EPA Science Inventory

    The publication, in two volumes, contains the text of all papers presented at EPA's fifth flue gas desulfurization (FGD) symposium, March 5-8, 1979, at Las Vegas, Nevada. A partial listing of papers in Volume 2 includes the following: Basin Electric's involvement with dry flue ga...

  19. Highlights from the Ninth International Symposium of Thrombosis and Anticoagulation (ISTA IX), October 15, 2016, Salvador, Bahia, Brazil.

    PubMed

    Lopes, Renato D; Guimarães, Patricia O; Hylek, Elaine; Feitosa-Filho, Gilson S; Ritt, Luiz; Filgueiras, Nivaldo; Darzé, Eduardo; Rocha, Mario S; Magalhães, Luis P; Sousa, Antonio Carlos Sobral; Correia, Luis Claudio; Oliveira, Lucas Hollanda; Garcia, David A

    2017-11-01

    To discuss and share knowledge about advances in the care of patients with thrombotic disorders, the Ninth International Symposium of Thrombosis and Anticoagulation was held in Salvador, Bahia, Brazil, on October 15, 2016. This scientific program was developed by clinicians for clinicians and was promoted by two major clinical research institutes-the Brazilian Clinical Research Institute and the Duke Clinical Research Institute of the Duke University School of Medicine. Comprising academic presentations and open discussion, the symposium had as its primary goal to educate, motivate, and inspire internists, cardiologists, hematologists, and other physicians by convening national and international visionaries, thought-leaders, and dedicated clinician-scientists. This paper summarizes the symposium proceedings.

  20. Proceedings of second annual underground coal gasification symposium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shuck, L Z

    The Second Annual Underground Coal Gasification Symposium was sponsored by the Morgantown Energy Research Center of the US Energy Research and Development Administration and held at Morgantown, WV, August 10-12, 1976. Fifty papers of the proceedings have been entered individually into EDB and ERA. While the majority of the contribution involved ERDA's own work in this area, there were several papers from universities, state organizations, (industrial, engineering or utility companies) and a few from foreign countries. (LTN)

  1. Major advances in the development of histamine H4 receptor ligands.

    PubMed

    Smits, Rogier A; Leurs, Rob; de Esch, Iwan J P

    2009-08-01

    The search for new and potent histamine H4 receptor ligands is leading to a steadily increasing number of scientific publications and patent applications. Several interesting and structurally diverse compounds have been found, but fierce IP competition for a preferred 2-aminopyrimidine scaffold is becoming apparent. Recent investigations into the role of the histamine H(4)R in (patho)physiology and the use of H4R ligands in in vivo disease models reveal enormous potential in the field of inflammation and allergy, among others. The development of ligands that display activity at two or more histamine receptor (HR) subtypes is another clinical opportunity that is currently being explored. Taken together, the histamine H4R field is gearing up for clinical studies and has the potential to deliver another generation of blockbuster drugs.

  2. Increased release of histamine in patients with respiratory symptoms related to perfume.

    PubMed

    Elberling, J; Skov, P S; Mosbech, H; Holst, H; Dirksen, A; Johansen, J D

    2007-11-01

    Environmental perfume exposure may cause respiratory symptoms. Individuals with asthma and perfume contact allergy report such symptoms more frequently than others. However, immunologic mechanisms have not been demonstrated and the symptoms are not associated with IgE-mediated allergy. The study aimed to investigate whether basophils from patients with respiratory symptoms related to perfume released more histamine in the presence of perfume as compared with healthy volunteers. Histamine release was measured by the glass fibre method. Blood was obtained from healthy volunteers (n=20) and patients with respiratory symptoms related to perfume (n=17) attending a dermatological outpatient clinic for patch testing. The effect of an international brand perfume was investigated using the basophil histamine release test with perfume. Furthermore, basophils from a healthy non-atopic donor were incubated with participant's sera and histamine release induced by perfume was measured. In both groups incremental perfume concentrations showed a positive and significant (P<0.001) dose-response effect on the release of histamine. At the highest perfume concentration, the basophils released significantly (P<0.05) more histamine in patients as compared with healthy volunteers. No difference was found between the groups when sera were incubated with basophils from a healthy non-atopic donor. Perfume induces a dose-dependent non-IgE-mediated release of histamine from human peripheral blood basophils. Increased basophil reactivity to perfume was found in patients with respiratory symptoms related to perfume.

  3. GRAPPA Trainees Symposium 2017: A Report from the GRAPPA 2017 Annual Meeting.

    PubMed

    Furer, Victoria; Manasson, Julia; Boehncke, Wolf-Henning; Ritchlin, Christopher T

    2018-06-01

    At the 2017 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) in Amsterdam, the Netherlands, a trainees symposium was held. Rheumatology and dermatology trainees engaged in psoriasis or psoriatic arthritis research presented their work. This report briefly reviews 6 oral presentations and 25 posters presented at the meeting.

  4. EURO/PAHO Symposium on Appropriate Technology Following Birth (Trieste, October 7-11, 1986). Summary Report.

    ERIC Educational Resources Information Center

    World Health Organization, Copenhagen (Denmark). Regional Office for Europe.

    In October, 1986, The World Health Organization's regional offices for Europe and the Americas held a joint symposium attended by over 40 participants from North and South America and Europe, including obstetricians, pediatricians, health administrators, sociologists, psychologists, economists, epidemiologists, medical journalists, and service…

  5. Symposium on Early Childhood Education (Urbana-Champaign, Illinois, November 9-10, 1997). Abstracts.

    ERIC Educational Resources Information Center

    Illinois Univ., Champaign. Coll. of Education.

    This book compiles abstracts of presentations from a symposium held in honor of Dr. Bernard Spodek, a leading scholar in early childhood education, on the occasion of his retirement. Topics addressed are as follows: (1) culture in early childhood curriculum; (2) developmental and cultural appropriateness; (3) kindergarten in Japan; (4) pressure…

  6. Sheep symposium: Biology and management of low-input lambing in easy-care systems

    USDA-ARS?s Scientific Manuscript database

    Low-input lambing management was the focus of the 2007 Sheep Symposium at the joint annual meetings of the American Society of Animal Science, the American Dairy Science Association, the Asociacio´n Mexicana de Produccio´n Animal, and the Poultry Science Association held in San Antonio, Texas, on Ju...

  7. Proceedings of the symposium on Giant Sequoias: their place in the ecosystem and society

    Treesearch

    Philip S. Aune

    1994-01-01

    These proceedings summarize the results of a blending of public perceptions, management, and research presented at a symposium on Giant Sequoias (Sequoiadendron giganteum), held in Visalia, California. Twenty-eight papers are included, focusing on six major topics: public values and perceptions, natural perspectives, disturbance environments, grove development,...

  8. Summary of the 24th International Symposium on Shock Waves

    NASA Astrophysics Data System (ADS)

    Jiang, Zonglin

    2005-06-01

    The 24th International Symposium on Shock Waves (ISSW24) was held at the Beijing Friendship Hotel from July 11 to July 16, 2004, in Beijing, China, after a one-year delay due to the SARS outbreak in Beijing shortly before the Symposium’s originally scheduled date in 2003. The event achieved success due to the continuous support and kind understanding from all the delegates and the International Advisory Committee. During the last three years, I have communicated constantly with so many people who encouraged me by providing their suggestions and advice whenever I was in need, from which I feel a sense of community: the community being full of friendship and understanding. It is very heart-warming to have such an experience and I am very happy to have served as chairman of the Symposium for such a community. On behalf of the Local Organizing Committee I would like to thank all of you for the contributions and help that you have given us, without which we would not have had the Symposium.

  9. CSF histamine contents in narcolepsy, idiopathic hypersomnia and obstructive sleep apnea syndrome.

    PubMed

    Kanbayashi, Takashi; Kodama, Tohru; Kondo, Hideaki; Satoh, Shinsuke; Inoue, Yuichi; Chiba, Shigeru; Shimizu, Tetsuo; Nishino, Seiji

    2009-02-01

    To (1) replicate our prior result of low cerebrospinal fluid (CSF) histamine levels in human narcolepsy in a different sample population and to (2) evaluate if histamine contents are altered in other types of hypersomnia with and without hypocretin deficiency. Cross sectional studies. Sixty-seven narcolepsy subjects, 26 idiopathic hypersomnia (IHS) subjects, 16 obstructive sleep apnea syndrome (OSAS) subjects, and 73 neurological controls were included. All patients were Japanese. Diagnoses were made according to ICSD-2. We found significant reductions in CSF histamine levels in hypocretin deficient narcolepsy with cataplexy (mean +/- SEM; 176.0 +/- 25.8 pg/mL), hypocretin non-deficient narcolepsy with cataplexy (97.8 +/- 38.4 pg/mL), hypocretin non-deficient narcolepsy without cataplexy (113.6 +/- 16.4 pg/mL), and idiopathic hypersomnia (161.0 +/- 29.3 pg/ mL); the levels in OSAS (259.3 +/- 46.6 pg/mL) did not statistically differ from those in the controls (333.8 +/- 22.0 pg/mL). Low CSF histamine levels were mostly observed in non-medicated patients; significant reductions in histamine levels were evident in non-medicated patients with hypocretin deficient narcolepsy with cataplexy (112.1 +/- 16.3 pg/ mL) and idiopathic hypersomnia (143.3 +/- 28.8 pg/mL), while the levels in the medicated patients were in the normal range. The study confirmed reduced CSF histamine levels in hypocretin-deficient narcolepsy with cataplexy. Similar degrees of reduction were also observed in hypocretin non-deficient narcolepsy and in idiopathic hypersomnia, while those in OSAS (non central nervous system hypersomnia) were not altered. The decrease in histamine in these subjects were more specifically observed in non-medicated subjects, suggesting CSF histamine is a biomarker reflecting the degree of hypersomnia of central origin.

  10. State-of-the-art methodology of forest inventory: a symposium proceedings.

    Treesearch

    Vernon J. LaBau; Tiberius Cunia

    1990-01-01

    The state-of-the-art of forest inventory methodology, being closely integrated with the fast-moving, high technology computer world, has been changing at a rapid pace over the past decade. Several successful conferences were held during the 1980s with the goal and purpose of staying abreast of such change. This symposium was conceived, not just with the idea of helping...

  11. Addendum: Tenth International Symposium on Alcohol Fuels, The road to commercialization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    The Tenth International Symposium on ALCOHOL FUELS ``THE ROAD TO COMMERCIALIZATION`` was held at the Broadmoor Hotel, Colorado Springs, Colorado, USA November 7--10, 1993. Twenty-seven papers on the production of alcohol fuels, specifications, their use in automobiles, buses and trucks, emission control, and government policies were presented. Individual papers have been processed separately for entry into the data base.

  12. EDITORIAL: The 14th International Symposium on Flow Visualization, ISFV14 The 14th International Symposium on Flow Visualization, ISFV14

    NASA Astrophysics Data System (ADS)

    Kim, Kyung Chun; Lee, Sang Joon

    2011-06-01

    The 14th International Symposium on Flow Visualization (ISFV14) was held in Daegu, Korea, on 21-24 June 2010. There were 304 participants from 17 countries. The state of the art in many aspects of flow visualization was presented and discussed, and a total of 243 papers from 19 countries were presented. Two special lectures and four invited lectures, 48 paper sessions and one poster session were held in five session rooms and in a lobby over four days. Among the paper sessions, those on 'biological flows', 'micro/nano fluidics', 'PIV/PTV' and 'compressible and sonic flows' received great attention from the participants of ISFV14. Special events included presentations of 'The Asanuma Award' and 'The Leonardo Da Vinci Award' to prominent contributors. Awards for photos and movies were given to three scientists for their excellence in flow visualizations. Sixteen papers were selected by the Scientific Committee of ISFV14. After the standard peer review process of this journal, six papers were finally accepted for publication. We wish to thank the editors of MST for making it possible to publish this special feature from ISFV14. We also thank the authors for their careful and insightful work and cooperation in the preparation of revised papers. It will be our pleasure if readers appreciate the hot topics in flow visualization research as a result of this special feature. We also hope that the progress in flow visualization will create new research fields. The 15th International Symposium on Flow Visualization will be held in Minsk, Belarus in 2012. We would like to express sincere thanks to the staff at IOP Publishing for their kind support.

  13. Repurposing a Histamine Detection Platform for High-Throughput Screening of Histidine Decarboxylase.

    PubMed

    Juang, Yu-Chi; Fradera, Xavier; Han, Yongxin; Partridge, Anthony William

    2018-06-01

    Histidine decarboxylase (HDC) is the primary enzyme that catalyzes the conversion of histidine to histamine. HDC contributes to many physiological responses as histamine plays important roles in allergic reaction, neurological response, gastric acid secretion, and cell proliferation and differentiation. Small-molecule modulation of HDC represents a potential therapeutic strategy for a range of histamine-associated diseases, including inflammatory disease, neurological disorders, gastric ulcers, and select cancers. High-throughput screening (HTS) methods for measuring HDC activity are currently limited. Here, we report the development of a time-resolved fluorescence resonance energy transfer (TR-FRET) assay for monitoring HDC activity. The assay is based on competition between HDC-generated histamine and fluorophore-labeled histamine for binding to a Europium cryptate (EuK)-labeled anti-histamine antibody. We demonstrated that the assay is highly sensitive and simple to develop. Assay validation experiments were performed using low-volume 384-well plates and resulted in good statistical parameters. A pilot HTS screen gave a Z' score > 0.5 and a hit rate of 1.1%, and led to the identification of a validated hit series. Overall, the presented assay should facilitate the discovery of therapeutic HDC inhibitors by acting as a novel tool suitable for large-scale HTS and subsequent interrogation of compound structure-activity relationships.

  14. 1976 Inter-university symposium on renewable resource assessment and programming: executive summary

    Treesearch

    Billy G. Pemberton

    1977-01-01

    The Forest and Rangeland Renewable Resources Planning Act of 1974 directs the Secretary of Agriculture to prepare an assessment of the nation's renewable resources and a program that will assure an adequate future supply of these resources. Responsibility for this work is assigned to the Forest Service. An inter-university symposium was held in 1976 to evaluate...

  15. Elevated blood histamine levels and mast cell degranulation in solar urticaria.

    PubMed Central

    Hawk, J L; Eady, R A; Challoner, A V; Kobza-Black, A; Keahey, T M; Greaves, M W

    1980-01-01

    1 Ultraviolet radiation (UVR)-induced wealing was studied in four patients with solar urticaria, whose measured action spectra were within the range 300 to 700 nm. 2 Elevated histamine levels were found in blood draining wealed skin in all four patients. 3 Histological and electron microscopial studies of the irradiated skin showed evidence of mast cell degranulation. 4 These findings demonstrate an association between histamine release from mast cells and wealing in solar urticaria, and should encourage evaluation of drugs which suppress histamine release in this disorder. Images Figure 2 PMID:7356907

  16. Extended-gate organic field-effect transistor for the detection of histamine in water

    NASA Astrophysics Data System (ADS)

    Minamiki, Tsukuru; Minami, Tsuyoshi; Yokoyama, Daisuke; Fukuda, Kenjiro; Kumaki, Daisuke; Tokito, Shizuo

    2015-04-01

    As part of our ongoing research program to develop health care sensors based on organic field-effect transistor (OFET) devices, we have attempted to detect histamine using an extended-gate OFET. Histamine is found in spoiled or decayed fish, and causes foodborne illness known as scombroid food poisoning. The new OFET device possesses an extended gate functionalized by carboxyalkanethiol that can interact with histamine. As a result, we have succeeded in detecting histamine in water through a shift in OFET threshold voltage. This result indicates the potential utility of the designed OFET devices in food freshness sensing.

  17. Proceedings of the 2016 National Toxicology Program Satellite Symposium

    PubMed Central

    Elmore, Susan A.; Chen, Vivian S.; Hayes-Bouknight, Schantel; Hoane, Jessica S.; Janardhan, Kyathanahalli; Kooistra, Linda H.; Nolte, Thomas; Szabo, Kathleen A.; Willson, Gabrielle A.; Wolf, Jeffrey C.; Malarkey, David E.

    2016-01-01

    The 2016 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri” was held in San Diego, California, at the Society of Toxicologic Pathology’s (STP) 35th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers’ talks, along with select images that were used by the audience for voting and discussion. Some lesions and topics covered during the symposium included malignant glioma and histiocytic sarcoma in the rodent brain; a new statistical method designed for histopathology data evaluation; uterine stromal/glandular polyp in a rat; malignant plasma cell tumor in a mouse brain; Schwann cell proliferative lesions in rat hearts; axillary schwannoma in a cat; necrosis and granulomatous inflammation in a rat brain; adenoma/carcinoma in a rat adrenal gland; hepatocyte maturation defect and liver/spleen hematopoietic defects in an embryonic mouse; distinguishing malignant glioma, malignant mixed glioma and malignant oligodendroglioma in the rat; comparison of mammary gland whole mounts and histopathology from mice; and discussion of the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) collaborations. PMID:27821709

  18. Building Partnerships to Promote Global Health Equity: Takeaways from the 6th Annual Symposium

    Cancer.gov

    CGH celebrated yet another successful and inspiring Annual Symposium on Global Cancer Research (ASGCR) held in conjunction with the 9th Annual CUGH (Consortium of University on Global Health) Conference on March 15, 2018 in New York, NY. Read more about ASGCR and new global collaborations in cancer research.

  19. Second Symposium on Protection Against Radiations in Space

    NASA Technical Reports Server (NTRS)

    Reetz, Arthur, Jr. (Editor)

    1965-01-01

    All space vehicles will be exposed to natural charged particle radiation fields. The effects and possible problems imposed by such radiations are of great concern to those actively engaged in the exploration of space. Materials and components, which may be damaged by the radiation, frequently can be replaced by more radiation resistant items; however, replacement systems are not always possible or practical and, hence, protective measures in the form of shielding must be employed. (One of the more radiation-sensitive systems to be flown in space is man himself.) Many groups are engaged in research on the attenuation and penetration of high-energy space radiation and on the development of methods for the design of shielding which affords protection against the radiation. The purpose of the Second Symposium on Protection Against Radiations in Space, like that of the First, was to bring these groups together to exchange information and share ideas. The First Symposium on the Protection Against Radiation Hazards in Space was held in Gatlinburg, Tenn., on November 5-7, 1962, and was sponsored by the NASA Manned Spacecraft Center, the Oak Ridge National Laboratory, and the American Nuclear Society. The proceedings of that symposium were published by the U.S. Atomic Energy Commission in a two volume report numbered TID-7652. Early in 1964, it became apparent that sufficient new information worthy of presentation in another symposium had been gathered. Because of its interest and role in space and related research, the U.S. Air Force joined NASA and AEC in the sponsorship of the Second Symposium at Gatlinburg in October 1964. The host, as before, was the Oak Ridge National Laboratory. These proceedings are the written record of the Second Symposium. Invited papers covering the space radiation environment, radiobiological effects, and radiation effects on materials and components comprised the first three sessions. By defining the radiation problems in space and providing

  20. Cold urticaria. Dissociation of cold-evoked histamine release and urticara following cold challenge.

    PubMed

    Keahey, T M; Greaves, M W

    1980-02-01

    Nine patients with acquired cold urticaria were studied to assess the effects of beta-adrenergic agents, xanthines, and corticosteroids on cold-evoked histamine release from skin in vivo. The patients, in all of whom an immediate urticarial response developed after cooling of the forearm, demonstrated release of histamine into the venous blood draining that forearm. Following treatment with aminophylline and albuterol in combination or prednisone alone, suppression of histamine release occurred in all but one patient. In some patients, this was accompanied by a subjective diminution in pruritus or buring, but there was no significant improvement in the ensuing edema or erythema. In one patient, total suppression of histamine release was achieved without any effect on whealing and erythema in response to cold challenge. Our results suggest that histamine is not central to the pathogenesis of vascular changes in acquired cold urticaria.

  1. Mosquito vector biology and control in latin america-a 24th symposium.

    PubMed

    Clark, Gary G; Fernández-Salas, Ildefonso

    2014-09-01

    The 24th Annual Latin American Symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 80th Annual Meeting in Seattle, WA, in February 2014. The principal objective, for the previous 23 symposia, was to promote participation in the AMCA by vector control specialists, public health workers, and academicians from Latin America. This publication includes summaries of 26 presentations that were given orally in Spanish or presented as posters by participants from Colombia, Mexico, and the USA. Topics addressed in the symposium included: surveillance, ecology, chemical control, studies of dengue viruses, and insecticide resistance associated with Aedes aegypti; Anopheles vectors of malaria; essential oils; and ethnic groups and vector-borne diseases.

  2. Glucagon effects on 3H-histamine uptake by the isolated guinea-pig heart during anaphylaxis.

    PubMed

    Rosic, Mirko; Parodi, Oberdan; Jakovljevic, Vladimir; Colic, Maja; Zivkovic, Vladimir; Jokovic, Vuk; Pantovic, Suzana

    2014-01-01

    We estimated the influence of acute glucagon applications on (3)H-histamine uptake by the isolated guinea-pig heart, during a single (3)H-histamine passage through the coronary circulation, before and during anaphylaxis, and the influence of glucagon on level of histamine, NO, O2 (-), and H2O2 in the venous effluent during anaphylaxis. Before anaphylaxis, glucagon pretreatment does not change (3)H-histamine Umax and the level of endogenous histamine. At the same time, in the presence of glucagon, (3)H-histamine Unet is increased and backflux is decreased when compared to the corresponding values in the absence of glucagon. During anaphylaxis, in the presence of glucagon, the values of (3)H-histamine Umax and Unet are significantly higher and backflux is significantly lower in the presence of glucagon when compared to the corresponding values in the absence of glucagon. The level of endogenous histamine during anaphylaxis in the presence of glucagon (6.9-7.38 × 10(-8) μM) is significantly lower than the histamine level in the absence of glucagon (10.35-10.45 × 10(-8) μM). Glucagon pretreatment leads to a significant increase in NO release (5.69 nmol/mL) in comparison with the period before glucagon administration (2.49 nmol/mL). Then, in the presence of glucagon, O2 (-) level fails to increase during anaphylaxis. Also, our results show no significant differences in H2O2 levels before, during, and after anaphylaxis in the presence of glucagon, but these values are significantly lower than the corresponding values in the absence of glucagon. In conclusion, our results show that glucagon increases NO release and prevents the increased release of free radicals during anaphylaxis, and decreases histamine level in the venous effluent during cardiac anaphylaxis, which may be a consequence of decreased histamine release and/or intensified histamine capturing by the heart during anaphylaxis.

  3. The first GCC Marine Biotechnology Symposium: Emerging Opportunities and Future Perspectives.

    PubMed

    Goddard, Stephen; Delghandi, Madjid; Dobretsov, Sergey; Al-Oufi, Hamed; Al-Habsi, Saoud; Burgess, J Grant

    2015-06-01

    With its diverse, living marine resources and rapidly growing educational and research infrastructure, the Sultanate of Oman is well-positioned to take advantage of the commercial opportunities presented by marine biotechnology. In recognition of potential development, an international symposium, Marine Biotechnology-Emerging Opportunities and Future Perspectives, was held in Muscat, November 12-13, 2013. Three keynote addresses were given, 23 oral presentations made, and a poster exhibition held. The final session reviewed national and regional issues, and the delegates agreed informally on a number of future actions. The potential for future development of marine biotechnology was recognized by all delegates, and following the symposium, they were surveyed for their views on how best to sustain and develop new activities. One hundred percent of respondents found the meeting useful and would support future symposia in the region. Fifty-one percent of Omani respondents recognized major organizational challenges and obstacles to the development of marine biotechnology compared with 23 % of overseas respondents. The need for greater collaboration between research institutions within the GCC region was recognized by 98 % of all respondents. The presentations and survey outcomes are reviewed in this paper.

  4. Non-Volatile Memory Technology Symposium 2000: Proceedings

    NASA Technical Reports Server (NTRS)

    Aranki, Nazeeh (Editor)

    2000-01-01

    This publication contains the proceedings for the Non-Volatile Memory Technology Symposium 2000 that was held on November 15-16, 2000 in Arlington, Virginia. The proceedings contains a wide range of papers that cover the presentations of myriad advances in the nonvolatile memory technology during the recent past including memory cell design, simulations, radiation environment, and emerging memory technologies. The papers presented in the proceedings address the design challenges and applications and deals with newer, emerging memory technologies as well as related issues of radiation environment and die packaging.

  5. The missing history of Bohm's hidden variables theory: The Ninth Symposium of the Colston Research Society, Bristol, 1957

    NASA Astrophysics Data System (ADS)

    Kožnjak, Boris

    2018-05-01

    In this paper, I analyze the historical context, scientific and philosophical content, and the implications of the thus far historically largely neglected Ninth Symposium of the Colston Research Society held in Bristol at the beginning of April 1957, the first major international event after World War II gathering eminent physicists and philosophers to discuss the foundational questions of quantum mechanics, in respect to the early reception of the causal quantum theory program mapped and defended by David Bohm during the five years preceding the Symposium. As will be demonstrated, contrary to the almost unanimously negative and even hostile reception of Bohm's ideas on hidden variables in the early 1950s, in the close aftermath of the 1957 Colston Research Symposium Bohm's ideas received a more open-minded and ideologically relaxed critical rehabilitation, in which the Symposium itself played a vital and essential part.

  6. CSF Histamine Contents in Narcolepsy, Idiopathic Hypersomnia and Obstructive Sleep Apnea Syndrome

    PubMed Central

    Kanbayashi, Takashi; Kodama, Tohru; Kondo, Hideaki; Satoh, Shinsuke; Inoue, Yuichi; Chiba, Shigeru; Shimizu, Tetsuo; Nishino, Seiji

    2009-01-01

    Study Objective: To (1) replicate our prior result of low cerebrospinal fluid (CSF) histamine levels in human narcolepsy in a different sample population and to (2) evaluate if histamine contents are altered in other types of hypersomnia with and without hypocretin deficiency. Design: Cross sectional studies. Setting and Patients: Sixty-seven narcolepsy subjects, 26 idiopathic hypersomnia (IHS) subjects, 16 obstructive sleep apnea syndrome (OSAS) subjects, and 73 neurological controls were included. All patients were Japanese. Diagnoses were made according to ICSD-2. Results: We found significant reductions in CSF histamine levels in hypocretin deficient narcolepsy with cataplexy (mean ± SEM; 176.0 ± 25.8 pg/mL), hypocretin non-deficient narcolepsy with cataplexy (97.8 ± 38.4 pg/mL), hypocretin non-deficient narcolepsy without cataplexy (113.6 ± 16.4 pg/mL), and idiopathic hypersomnia (161.0 ± 29.3 pg/mL); the levels in OSAS (259.3 ± 46.6 pg/mL) did not statistically differ from those in the controls (333.8 ± 22.0 pg/mL). Low CSF histamine levels were mostly observed in non-medicated patients; significant reductions in histamine levels were evident in non-medicated patients with hypocretin deficient narcolepsy with cataplexy (112.1 ± 16.3 pg/mL) and idiopathic hypersomnia (143.3 ± 28.8 pg/mL), while the levels in the medicated patients were in the normal range. Conclusion: The study confirmed reduced CSF histamine levels in hypocretin-deficient narcolepsy with cataplexy. Similar degrees of reduction were also observed in hypocretin non-deficient narcolepsy and in idiopathic hypersomnia, while those in OSAS (non central nervous system hypersomnia) were not altered. The decrease in histamine in these subjects were more specifically observed in non-medicated subjects, suggesting CSF histamine is a biomarker reflecting the degree of hypersomnia of central origin. Citation: Kanbayashi T; Kodama T; Kondo H; Satoh S; Inoue Y; Chiba S; Shimizu T; Nishino S. CSF

  7. Histamine H2 receptor - Involvement in gastric ulceration

    NASA Technical Reports Server (NTRS)

    Brown, P. A.; Vernikos-Danellis, J.; Brown, T. H.

    1976-01-01

    The involvement of the H1 and H2 receptors for histamine in the pathogenesis of gastric ulcers was investigated in rats. Metiamide, an H2 receptor antagonist, reliably reduced ulceration produced by stress alone or by a combination of stress and aspirin. In contrast, pyrilamine, which blocks only the H1 receptor, was without effect under these same conditions. The results support the hypothesis that histamine mediates both stress and stress plus aspirin induced ulceration by a mechanism involving the H2 receptor.

  8. Ferroelectric Thin Films III, Symposium Held in San Francisco, California on April 13 - 16, 1993. Materials Research Society Symposium Proceedings, Volume 310

    DTIC Science & Technology

    1993-04-16

    and A. Ishitani AUTHOR INDEX 495 SUBJECT INDEX 499 *Invited Paper x Preface This symposium showcased the advancement in processing technology and...Layers of this thickness still are in advance of current fabrication technology , but do now appear to be within the bounds of possibility. Figure 6...Krusor of Xerox PARC for technical assistance. This work has been supported in part by the Department of Commerce Advanced Technology Program

  9. Abstracts of papers presented at the LVIII Cold Spring Harbor Symposium on quantitative Biology: DNA and chromosomes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This volume contains the abstracts of oral and poster presentations made at the LVIII Cold Spring Harbor Symposium on Quantitative Biology entitles DNA & Chromosomes. The meeting was held June 2--June 9, 1993 at Cold Spring Harbor, New York.

  10. The Symposium on the Evaluation of Foreign Language Proficiency: Challenges to the Profession.

    ERIC Educational Resources Information Center

    Valdman, Albert

    This paper presents a report of a 1987 symposium on the Evaluation of Foreign Language Proficiency held in Bloomington, Indiana. Although much has been accomplished in language testing, much remains to be done before the language teaching profession has at its disposal a common means of measuring proficiency in the functional use of language in…

  11. Proceedings of the Southern Regional Information Exchange Group Biennial Symposium on Forest Genetics

    Treesearch

    G. Sam Foster; Alex M. Diner; [Editors

    1994-01-01

    This volume is the proceedings of the 1992 Southern Regional Information Exchange Group (SRIEG) Biennial Symposium on Forest Genetics. The meeting was held in Huntsville, Alabama, USA on July 8-10, 1992 and was entitled, "Applications of Vegetative Propagation in Forestry." The nine papers were divided into three sets under the headings: "Tissue Culture...

  12. Proceedings of the Stake Symposium on Educational Evaluation (Champaign, Illinois, May 8-9, 1998).

    ERIC Educational Resources Information Center

    Davis, Rita, Ed.

    A symposium on educational evaluation was held to celebrate the career of Robert E. Stake. Contributions, which relate to many aspects of educational evaluation, include: (1) "The Issue of Advocacy in Evaluation" (Ernest House and Kenneth Howe); (2) "The Meaning of Bias" (Michael Scriven); (3) Commentary on Ernie House and…

  13. PREFACE: 9th National Symposium on Polymeric Materials (NSPM 2009)

    NASA Astrophysics Data System (ADS)

    Ali, Aidy; Salit, Sapuan

    2010-07-01

    NSPM 2009 is the formal proceedings of the 9th National Symposium on Polymeric Materials held in Residence Hotel Uniten Bangi on 14-16 December 2009. It is also organised with The Plastics and Rubber Institute Malaysia PRIM. The symposium proceedings consists of 94 papers covering a large number of issues on experimental and analytical studies of polymeric materials. The objectives of the symposium are to review the state-of-the art, present and latest findings and exchange ideas among engineers, researchers and practitioners involved in this field. We strongly hope the outcomes of this symposium will stimulate and enhanced the progress of experimental and analytical studies on polymeric materials as well as contribute to the fundamental understanding in related fields. After careful refereeing of all manuscripts, 15 papers were selected for publications in this issue. Another 20 papers were selected for publication in Pertanika Journal of Science and Technology (PJST). The content of the material and its rapid dissemination was considered to be more important than its form. We are grateful to all the authors for their papers and presentations in this symposium. They are also the ones who help make this symposium possible through their hard work in the preparation of the manuscripts. We would also like to offer our sincere thanks to all the invited speakers who came to share their knowledge with us. We would also like to acknowledge the untiring efforts of the reviewers, research assistants and students in meeting deadlines and for their patience and perseverance. We are indeed honoured to associate this event with Department of Mechanical and Manufacturing, and Faculty of Engineering, Universiti Putra Malaysia. Finally, we appreciate the sponsor support provided by Faculty of Engineering, The Plastics and Rubber Institute Malaysia (PRIM) and PETRONAS Malaysia. Thank you all. Editors: Aidy Ali and S M Sapuan

  14. Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil models

    PubMed Central

    Langdon, Jacqueline M.; Schroeder, John T.; Vonakis, Becky M.; Bieneman, Anja P.; Chichester, Kristin; MacDonald, Susan M.

    2008-01-01

    Previously, we demonstrated a negative correlation between histamine release to histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP) and protein levels of SHIP-1 in human basophils. The present study was conducted to investigate whether suppressing SHIP-1 using small interfering (si)RNA technology would alter the releasability of culture-derived mast cells and basophils, as determined by HRF/TCTP histamine release. Frozen CD34+ cells were obtained from the Fred Hutchinson Cancer Research Center (Seattle, WA, USA). Cells were grown in StemPro-34 medium containing cytokines: mast cells with IL-6 and stem cell factor (100 ng/ml each) for 6–8 weeks and basophils with IL-3 (6.7 ng/ml) for 2–3 weeks. siRNA transfections were performed during Week 6 for mast cells and Week 2 for basophils with siRNA for SHIP-1 or a negative control siRNA. Changes in SHIP-1 expression were determined by Western blot. The functional knockdown was measured by HRF/TCTP-induced histamine release. siRNA knockdown of SHIP-1 in mast cells ranged from 31% to 82%, mean 65 ± 12%, compared with control (n=4). Histamine release to HRF/TCTP was increased only slightly in two experiments. SHIP-1 knockdown in basophils ranged from 34% to 69%, mean 51.8 ± 7% (n=4). Histamine release to HRF/TCTP in these basophils was dependent on the amount of SHIP knockdown. Mast cells and basophils derived from CD34+ precursor cells represent suitable models for transfection studies. Reducing SHIP-1 protein in cultured mast cells and in cultured basophils increases releasability of the cells. PMID:18625911

  15. PCR detection and identification of histamine-forming bacteria in filleted tuna fish samples.

    PubMed

    Ferrario, Chiara; Pegollo, Chiara; Ricci, Giovanni; Borgo, Francesca; Fortina, M Grazia

    2012-02-01

    Total of 14 filleted yellowfin tuna fish (Thunnus albacares) sold in wholesale fish market and supermarkets in Milan, Italy, were purchased and tested to determine microbial count, histamine level, histamine-forming bacteria, and their ability to produce histamine in culture broth. Although histamine level was less than 10 ppm, many samples showed high total viable bacterial and enterobacterial counts that reached dangerous levels after temperature abuse for short periods of time. A PCR assay targeting a 709-bp fragment of the histidine decarboxylase gene (hdc) revealed that 30.5% of the 141 enteric bacteria isolated from samples were positive and potentially able to produce histamine. The hdc positive strains were mainly isolated from fish bought at wholesale fish market, where we observed several possible risk factors, such as handling in poor and non-refrigerated conditions during fillet preparation. These positive strains were identified as Citrobacter koseri/Enterobacter spp. and Morganella morganii, by 16S/23S rRNA internal transcribed spacer amplification and 16S rRNA sequence analysis. The strains showed a variable ability of histamine production, with Morganella morganii being the most active histamine-producing species. A direct DNA extraction from fish and a PCR targeting the hdc gene showed a high degree of concordance with the results obtained through microbiological and chemical analyses, and could aid in the prompt detection of potentially contaminated fish products, before histamine accumulates. The use of methods for the early and rapid detection of bacteria producing biogenic amines is important for preventing accumulation of these toxic substances in food products. In this study, we used a molecular approach for the detection of histamine-forming bacteria in fish. PCR-based methods require expensive equipment and a high degree of training for the user, but are fast (< 24 h) and reliable. They now represent the best predictive methods to identify

  16. Histamine Poisoning from Ingestion of Fish or Scombroid Syndrome

    PubMed Central

    Tortorella, Vincenzo; Masciari, Peppino; Pezzi, Mario; Mola, Assunta; Tiburzi, Simona Paola; Zinzi, Maria Concetta; Scozzafava, Annamaria; Verre, Mario

    2014-01-01

    The scombroid poisoning is due to the ingestion of poorly preserved fish (especially tuna, sardines, and mackerel) out of the cold chain. Under the influence of the proliferation of gram negative bacteria that occurs for heating, the histidine content in the muscle of the fish is converted into histamine, by the action of the enzyme histidine decarboxylase. If the histamine is ingested in large quantities, it causes an anaphylactoid reaction with a variety of symptoms from moderate to severe to life-threating. We will describe two cases that came under our observation after consuming a meal of bluefin tuna. The diagnosis of scombroid syndrome was made on the basis of the anamnestic data and the clinical one. The rapid resolution of the signs and symptoms after treatment with histamines H1-H2 receptor blockers confirmed the suspected diagnosis. PMID:25544905

  17. Histamine poisoning from ingestion of fish or scombroid syndrome.

    PubMed

    Tortorella, Vincenzo; Masciari, Peppino; Pezzi, Mario; Mola, Assunta; Tiburzi, Simona Paola; Zinzi, Maria Concetta; Scozzafava, Annamaria; Verre, Mario

    2014-01-01

    The scombroid poisoning is due to the ingestion of poorly preserved fish (especially tuna, sardines, and mackerel) out of the cold chain. Under the influence of the proliferation of gram negative bacteria that occurs for heating, the histidine content in the muscle of the fish is converted into histamine, by the action of the enzyme histidine decarboxylase. If the histamine is ingested in large quantities, it causes an anaphylactoid reaction with a variety of symptoms from moderate to severe to life-threating. We will describe two cases that came under our observation after consuming a meal of bluefin tuna. The diagnosis of scombroid syndrome was made on the basis of the anamnestic data and the clinical one. The rapid resolution of the signs and symptoms after treatment with histamines H1-H2 receptor blockers confirmed the suspected diagnosis.

  18. Abstracts for the symposium on the Application of neural networks to the earth sciences

    USGS Publications Warehouse

    Singer, Donald A.

    2002-01-01

    Artificial neural networks are a group of mathematical methods that attempt to mimic some of the processes in the human mind. Although the foundations for these ideas were laid as early as 1943 (McCulloch and Pitts, 1943), it wasn't until 1986 (Rumelhart and McClelland, 1986; Masters, 1995) that applications to practical problems became possible. It is the acknowledged superiority of the human mind at recognizing patterns that the artificial neural networks are trying to imitate with their interconnected neurons. Interconnections used in the methods that have been developed allow robust learning. Capabilities of neural networks fall into three kinds of applications: (1) function fitting or prediction, (2) noise reduction or pattern recognition, and (3) classification or placing into types. Because of these capabilities and the powerful abilities of artificial neural networks, there have been increasing applications of these methods in the earth sciences. The abstracts in this document represent excellent samples of the range of applications. Talks associated with the abstracts were presented at the Symposium on the Application of Neural Networks to the Earth Sciences: Seventh International Symposium on Mineral Exploration (ISME–02), held August 20–21, 2002, at NASA Moffett Field, Mountain View, California. This symposium was sponsored by the Mining and Materials Processing Institute of Japan (MMIJ), the U.S. Geological Survey, the Circum-Pacific Council, and NASA. The ISME symposia have been held every two years in order to bring together scientists actively working on diverse quantitative methods applied to the earth sciences. Although the title, International Symposium on Mineral Exploration, suggests exclusive focus on mineral exploration, interests and presentations have always been wide-ranging—abstracts presented here are no exception.

  19. NASA Earth Resources Survey Symposium. Volume 3: Summary reports

    NASA Technical Reports Server (NTRS)

    1975-01-01

    This document contains the proceedings and summaries of the earth resources survey symposium, sponsored by the NASA Headquarters Office of Applications and held in Houston, Texas, June 9 to 12, 1975. Topics include the use of remote sensing techniques in agriculture, in geology, for environmental monitoring, for land use planning, and for management of water resources and coastal zones. Details are provided about services available to various users. Significant applications, conclusions, and future needs are also discussed.

  20. Chemical and Thermodynamic Properties at High Temperatures: A Symposium

    NASA Technical Reports Server (NTRS)

    Walker, Raymond F.

    1961-01-01

    This book contains the program and all available abstracts of the 90' invited and contributed papers to be presented at the TUPAC Symposium on Chemical and Thermodynamic Properties at High Temperatures. The Symposium will be held in conjunction with the XVIIIth IUPAC Congress, Montreal, August 6 - 12, 1961. It has been organized, by the Subcommissions on Condensed States and on Gaseous States of the Commission on High Temperatures and Refractories and by the Subcommission on Experimental Thermodynamics of the Commission on Chemical Thermodynamics, acting in conjunction with the Organizing Committee of the IUPAC Congress. All inquiries concerning participation In the Symposium should be directed to: Secretary, XVIIIth International Congress of Pure and Applied Chemistry, National Research Council, Ottawa, 'Canada. Owing to the limited time and facilities available for the preparation and printing of the book, it has not been possible to refer the proofs of the abstracts to the authors for checking. Furthermore, it has not been possible to subject the manuscripts to a very thorough editorial examination. Some obvious errors in the manuscripts have been corrected; other errors undoubtedly have been introduced. Figures have been redrawn only when such a step was essential for reproduction purposes. Sincere apologies are offered to authors and readers for any errors which remain; however, in the circumstances neither the IUPAC Commissions who organized the Symposium, nor the U. S. Government Agencies who assisted in the preparation of this book can accept responsibility for the errors.

  1. Histamine production by Enterobacter aerogenes in sailfish and milkfish at various storage temperatures.

    PubMed

    Tsai, Yung-Hsiang; Chang, Shiou-Chung; Kung, Hsien-Feng; Wei, Cheng-I; Hwang, Deng-Fwu

    2005-08-01

    Enterobacter aerogenes was studied for its growth and ability to promote the formation of total volatile base nitrogen (TVBN) and histamine in sailfish (Istiophorus platypterus) and milkfish (Chanos chanos) stored at various temperatures from -20 to 37 degrees C. The optimal temperature for bacterial growth in both fish species was 25 degrees C, whereas the optimal temperature for histamine formation was 37 degrees C. The two fish species inoculated with E. aerogenes, when not properly stored at low temperatures such as 15 degrees C for 36 h, formed histamine at above the U.S. Food and Drug Administration hazardous guideline level of 50 mg/100 g. Milkfish was a better substrate than sailfish for histamine formation by bacterial histidine decarboxylation at elevated temperatures (> 15 degrees C). Although higher contents of TVBN were detected in the spiked sailfish than milkfish during the same storage time at temperatures above 15 degrees C, the use of the 30-mg/100 g level of TVBN as a determination index for fish quality and decomposition was not a good criterion for assessing potential histamine hazard for both fish species. Bacterial growth was controlled by cold storage of the fish at 4 degrees C or below, but histamine formation was stopped only by frozen storage. Once the frozen fish samples were thawed and stored at 25 degrees C, histamine started to accumulate rapidly and reached levels greater than the hazardous action level in 36 h.

  2. Histamine excites groups III and IV afferents from the cat knee joint depending on their resting activity.

    PubMed

    Herbert, M K; Just, H; Schmidt, R F

    2001-06-08

    The effect of histamine on the sensory activity of primary afferents was studied in normal and acutely inflamed cat knee joints. A subpopulation of groups III and IV articular afferents could be activated by close-arterial bolus injections of histamine: units with a high resting activity (about 100/min) were particular sensitive to histamine and were excited even by 3.3 fg histamine. The lower the resting discharges of groups III and IV units both from normal and acutely inflamed joints, the higher the dose of histamine (up to 3.3 or 33 microg) necessary to excite the nerve fibres. Thirty-seven of 39 units without any resting activity were completely insensitive to histamine. In contrast to its clear excitatory effect, histamine caused only minor changes in the responses to joint movements. Movement-evoked activity remained unchanged in 22 of 28 units, 1 unit was sensitized and 5 units showed reduced activity after histamine (3.3 microg). The present results support the notion that histamine may participate in the mediation of pain from injured or inflamed tissue. It is remarkable that histamine has a profound excitatory action on a proportion of both groups III and IV articular afferents without changing their sensitivity to joint movements.

  3. Proceedings of the symposium on the ecology, management, and utilization of California oaks, June 26-28

    Treesearch

    Timothy R. Plumb

    1980-01-01

    The symposium, held at Scripps College in Southern California, addressed most aspects of California's vast oak resource. Papers represented four major subject categories: ecological relationships, silviculture and management, damage factors, and products. Both scientific and applied information was presented, including original material not published previously....

  4. Tunisia-Japan Symposium: R&D of Energy and Material Sciences for Sustainable Society

    NASA Astrophysics Data System (ADS)

    Akimoto, Katsuhiro; Suzuki, Yoshikazu; Monirul Islam, Muhammad

    2015-04-01

    This volume of the Journal of Physics: Conference Series contains papers presented at the Tunisia-Japan Symposium: R&D of Energy and Material Sciences for Sustainable Society (TJS 2014) held at Gammarth, Republic of Tunisia on November 28-30, 2014. The TJS 2014 is based on the network of the Tunisia-Japan Symposium on Science, Society and Technology (TJASSST) which has been regularly organized since 2000. The symposium was focused on the technological developments of energy and materials for the realization of sustainable society. To generate technological breakthrough and innovation, it seems to be effective to discuss with various fields of researchers such as solid-state physicists, chemists, surface scientists, process engineers and so on. In this symposium, there were as many as 109 attendees from a wide variety of research fields. The technical session consisted of 106 contributed presentations including 3 plenary talks and 7 key-note talks. We hope the Conference Series and publications like this volume will contribute to the progress in research and development in the field of energy and material sciences for sustainable society and in its turn contribute to the creation of cultural life and peaceful society.

  5. Symposium of Hope: Recovery and Resiliency after the Sandy Hook Tragedy. Crisis Management

    ERIC Educational Resources Information Center

    Zenere, Frank J.

    2013-01-01

    On February 27 and 28, 2013, The Symposium of Hope: Recovery and Resilience after the Sandy Hook Tragedy, was held in Danbury, Connecticut. The event was hosted by the United Way of Western Connecticut and Western Connecticut State University. Frank J. Zenere, school psychologist and crisis team member in the Division of Student Services of the…

  6. ILO European Symposium on Work for the Disabled. Vocational Rehabilitation and Employment Creation (Warsaw, Poland, May 21-27, 1979; Stockholm, Sweden, May 27-June 1, 1979).

    ERIC Educational Resources Information Center

    Cooper, N., Ed.

    This document is a report on a 12-day symposium on work for the disabled--vocational rehabilitation and employment creation--which was held in Poland and Sweden in 1979. The symposium was organized jointly by the government of Poland and Sweden in close cooperation with the International Labour Office (ILO), Geneva. The report is divided into five…

  7. Determination of Air Quality. Proceedings of the ACS Symposium on Determination of Air Quality.

    ERIC Educational Resources Information Center

    Mamantov, Gleb, Ed.; Shults, W. D., Ed.

    Composed of data submitted by a variety of experts in the field, this book provides an introduction to air pollution control. It contains the proceedings of the American Chemical Society Symposium on Determination of Air Quality held in Los Angeles, California, April 1-2, 1971. Contributions from chemists, physicians, engineers, administrators,…

  8. Brain Death and Human Organismal Integration: A Symposium on the Definition of Death

    PubMed Central

    Moschella, Melissa

    2016-01-01

    Does the ability of some brain dead bodies to maintain homeostasis with the help of artificial life support actually imply that those bodies are living human organisms? Or might it be possible that a brain dead body on life support is a mere collection of still-living cells, organs and tissues which can coordinate with one another, but which lack the genuine integration that is the hallmark of a unified human organism as a whole? To foster further study of these difficult and timely questions, a Symposium on the Definition of Death was held at The Catholic University of America in June 2014. The Symposium brought together scholars from a variety of disciplines—law, medicine, biology, philosophy and theology—who all share a commitment to the dead donor rule and to a biological definition of death, but who have differing opinions regarding the validity of neurological criteria for human death. The papers found in this special issue are among the fruits of this Symposium. PMID:27107428

  9. Bioautography-guided isolation of antibacterial compounds of essential oils from Thai spices against histamine-producing bacteria.

    PubMed

    Lomarat, Pattamapan; Phanthong, Phanida; Wongsariya, Karn; Chomnawang, Mullika Traidej; Bunyapraphatsara, Nuntavan

    2013-05-01

    The outbreak of histamine fish poisoning has been being an issue in food safety and international trade. The growth of contaminated bacterial species including Morganella morganii which produce histidine decarboxylase causes histamine formation in fish during storage. Histamine, the main toxin, causes mild to severe allergic reaction. At present, there is no well-established solution for histamine fish poisoning. This study was performed to determine the antibacterial activity of essential oils from Thai spices against histamine-producing bacteria. Among the essential oils tested, clove, lemongrass and sweet basil oils were found to possess the antibacterial activity. Clove oil showed the strongest inhibitory activity against Morganella morganii, followed by lemongrass and sweet basil oils. The results indicated that clove, lemongrass and sweet basil oils could be useful for the control of histamine-producing bacteria. The attempt to identify the active components using preparative TLC and GC/MS found eugenol, citral and methyl chavicol as the active components of clove, lemongrass and sweet basil oils, respectively. The information from this study would be useful in the research and development for the control of histamine-producing bacteria in fish or seafood products to reduce the incidence of histamine fish poisoning.

  10. Early and late histamine release induced by albumin, hetastarch and polygeline: some unexpected findings.

    PubMed

    Celik, I; Duda, D; Stinner, B; Kimura, K; Gajek, H; Lorenz, W

    2003-10-01

    The perioperative use of colloidal plasma substitutes is still under discussion. We therefore conducted a prospective randomised study with three commonly used plasma substitutes to examine their histamine releasing effects in 21 volunteers. MATERIAL OR SUBJETS: 21 male volunteers were enrolled in this prospective, randomised, controlled clinical study. Endpoints were the incidence of early and late histamine release and the time course of the release kinetics. Normovolemic hemodilution technique was used with hydroxyethyl starch (n = 6), human albumin (n = 6) and polygeline (n = 9). Measurement and observation period was 240 min after the start of the plasma substitute infusion. Heart rate, blood pressure, SaO(2), clinical symptoms/signs and plasma histamine were measured during the observation period. The incidence of histamine release over the whole observation period in all three groups was 100%. Histamine release occurred frequently in all three groups until 30 min (50%-78%) and up to 240 min (late release reaction: 67%-83%) after the start of infusion. Surprisingly even hydroxyethyl starch, which is regarded as a generally safe and effective plasma substitute, caused high incidences of late histamine release (67%). Histamine release is a well known side effect of polygeline and - to a lesser extent - also of albumin, but was a novel finding for hydroxyethyl starch. We demonstrated for the first time histamine releasing effects of hydroxyethyl starch over a long period of time after administration. This perioperatively and for intensive care possibly relevant finding should make clinicians aware of late side effects not yet connected with the clinical use of these colloidal plasma substitutes.

  11. Effect of terfenadine on nasal, eustachian tube, and pulmonary function after provocative intranasal histamine challenge.

    PubMed

    Skoner, D P; Doyle, W J; Boehm, S; Fireman, P

    1991-12-01

    Previous studies have documented that intranasal histamine challenge results in nasal and eustachian tube obstruction (ETO) in human volunteers. The purpose of the present study was to assess the effect of pretreatment with terfenadine, a nonsedating antihistamine on the pathophysiologic consequences of intranasal histamine challenge. Fifteen subjects with allergic rhinitis were challenged intranasally with saline and increasing histamine doses (0.01, 0.1, 0.5, 1.0, 5.0, and 10.0 mg) before pretreatment (baseline) and after 1 week of pretreatment with terfenadine, 60 mg b.i.d., terfenadine, 120 mg b.i.d., and placebo. Nasal conductance as measured by posterior rhinomanometry showed a dose-dependent, monotonic decrease following sequential administration of the histamine solutions, but there were no apparent differences in the average responses among the four challenge sessions. The frequency of ETO after histamine challenge was decreased by pretreatment with both doses of terfenadine, although this was not significant. Histamine-induced sneezing and rhinorrhea, but not congestion, were significantly reduced by terfenadine pretreatment. There was no evidence of extension of the histamine effects to the lower airway. The results of the present study suggest that terfenadine, a nonsedating antihistamine, had a favorable effect on sneezing and rhinorrhea after provocative intranasal histamine challenge, but did not significantly attenuate the subjective or objective nasal and ET obstructive responses.

  12. Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium

    PubMed Central

    Akassoglou, Katerina; Agalliu, Dritan; Chang, Christopher J.; Davalos, Dimitrios; Grutzendler, Jaime; Hillman, Elizabeth M. C.; Khakh, Baljit S.; Kleinfeld, David; McGavern, Dorian B.; Nelson, Sarah J.; Zlokovic, Berislav V.

    2016-01-01

    Breakthrough advances in intravital imaging have launched a new era for the study of dynamic interactions at the neurovascular interface in health and disease. The first Neurovascular and Immuno-Imaging Symposium was held at the Gladstone Institutes, University of California, San Francisco in March, 2015. This highly interactive symposium brought together a group of leading researchers who discussed how recent studies have unraveled fundamental biological mechanisms in diverse scientific fields such as neuroscience, immunology, and vascular biology, both under physiological and pathological conditions. These Proceedings highlight how advances in imaging technologies and their applications revolutionized our understanding of the communication between brain, immune, and vascular systems and identified novel targets for therapeutic intervention in neurological diseases. PMID:26941593

  13. Noxious heat and scratching decrease histamine-induced itch and skin blood flow.

    PubMed

    Yosipovitch, Gil; Fast, Katharine; Bernhard, Jeffrey D

    2005-12-01

    The aim of this study was to assess the effect of thermal stimuli or distal scratching on skin blood flow and histamine-induced itch in healthy volunteers. Twenty-one healthy volunteers participated in the study. Baseline measurements of skin blood flow were obtained on the flexor aspect of the forearm. These measurements were compared with skin blood flow after various stimuli: heating the skin, cooling the skin, noxious cold 2 degrees C, noxious heat 49 degrees C, and scratching via a brush with controlled pressure. Afterwards histamine iontophoresis was performed and skin blood flow and itch intensity were measured immediately after the above-mentioned stimuli. Scratching reduced mean histamine-induced skin blood flow and itch intensity. Noxious heat pain increased basal skin blood flow but reduced histamine-induced maximal skin blood flow and itch intensity. Cold pain and cooling reduced itch intensity, but neither affected histamine-induced skin blood flow. Sub-noxious warming the skin did not affect the skin blood flow or itch intensity. These findings suggest that heat pain and scratching may inhibit itch through a neurogenic mechanism that also affects skin blood flow.

  14. International Symposium on Clusters and Nanostructures (Energy, Environment, and Health)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jena, Puru

    The international Symposium on Clusters and Nanostructures was held in Richmond, Virginia during November 7-10, 2011. The symposium focused on the roles clusters and nanostructures play in solving outstanding problems in clean and sustainable energy, environment, and health; three of the most important issues facing science and society. Many of the materials issues in renewable energies, environmental impacts of energy technologies as well as beneficial and toxicity issues of nanoparticles in health are intertwined. Realizing that both fundamental and applied materials issues require a multidisciplinary approach the symposium provided a forum by bringing researchers from physics, chemistry, materials science, andmore » engineering fields to share their ideas and results, identify outstanding problems, and develop new collaborations. Clean and sustainable energy sessions addressed challenges in production, storage, conversion, and efficiency of renewable energies such as solar, wind, bio, thermo-electric, and hydrogen. Environmental issues dealt with air- and water-pollution and conservation, environmental remediation and hydrocarbon processing. Topics in health included therapeutic and diagnostic methods as well as health hazards attributed to nanoparticles. Cross-cutting topics such as reactions, catalysis, electronic, optical, and magnetic properties were also covered.« less

  15. Symposium on Population and Human Rights.

    PubMed

    1981-06-01

    The objectives of the Symposium on Population and Human Rights, held at the Vienna International Center during June 1981, included the following: to review the progress or lack thereof in the observance of human rights in the context of demographic, economic and social conditions and changes since the Amsterdam Symposium of 1974; to review leading population trends and policy changes since 1974 and also examine some possible implications of recent development in the field of medicine, biology, and genetic engineering; and to identify which conceptions of human rights relating to demographic phenomenon are appropriate for today's population problems and to formulate guidelines and standards suitable for these problems. The agenda for the Symposium, attended by about 27 distinguished jurists and demographers, covered the following items: human rights and population trends and policies; morbidity/mortality and human rights; fertility and human rights; internal migration and human rights; status of women, population, and human rights; and new institutional functions in the area of human rights and population. The following were among the main themes and recommendations of the Symposium: 1) the problems of human rights should be contextually handled in such a way as to take adequate account of prevailing socioeconomic and cultural conditions; 2) the realization of a positive right to individual and social development is often impeded, particularly in developing areas, by the prevalence of high mortality, malnutrition, and inadequate health services; 3) policies designed to influence fertility should, within the framework of general population policies, be part of the national strategy for general development; 4) the Symposium recognized the problems of monitoring and appraising the observance or violation of human rights as they relate to the rights of the individual to free movement and residence and the rights to work and decent living; 5) considering the significant

  16. Production, management, and environment symposium: Environmental footprint of livestock production - Greenhouse gas emissions and climate change

    USDA-ARS?s Scientific Manuscript database

    This manuscript is the introduction to the 2015 Production, Management, and Environment symposium titled “Environmental Footprint of Livestock Production – Greenhouse Gas Emissions and Climate Change” that was held at the Joint Annual Meeting of the ASAS and ADSA at the Rosen Shingle Creek Resort in...

  17. Quantitative electrophysiological monitoring of anti-histamine drug effects on live cells via reusable sensor platforms.

    PubMed

    Pham Ba, Viet Anh; Cho, Dong-Guk; Kim, Daesan; Yoo, Haneul; Ta, Van-Thao; Hong, Seunghun

    2017-08-15

    We demonstrated the quantitative electrophysiological monitoring of histamine and anti-histamine drug effects on live cells via reusable sensor platforms based on carbon nanotube transistors. This method enabled us to monitor the real-time electrophysiological responses of a single HeLa cell to histamine with different concentrations. The measured electrophysiological responses were attributed to the activity of histamine type 1 receptors on a HeLa cell membrane by histamine. Furthermore, the effects of anti-histamine drugs such as cetirizine or chlorphenamine on the electrophysiological activities of HeLa cells were also evaluated quantitatively. Significantly, we utilized only a single device to monitor the responses of multiple HeLa cells to each drug, which allowed us to quantitatively analyze the antihistamine drug effects on live cells without errors from the device-to-device variation in device characteristics. Such quantitative evaluation capability of our method would promise versatile applications such as drug screening and nanoscale bio sensor researches. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms

    PubMed Central

    Yan, Haijing; Zhang, Xiangnan; Hu, Weiwei; Ma, Jing; Hou, Weiwei; Zhang, Xingzhou; Wang, Xiaofen; Gao, Jieqiong; Shen, Yao; Lv, Jianxin; Ohtsu, Hiroshi; Han, Feng; Wang, Guanghui; Chen, Zhong

    2014-01-01

    The role of the histamine H3 receptor (H3R) in cerebral ischaemia/reperfusion (I/R) injury remains unknown. Here we show that H3R expression is upregulated after I/R in two mouse models. H3R antagonists and H3R knockout attenuate I/R injury, which is reversed by an H3R-selective agonist. Interestingly, H1R and H2R antagonists, a histidine decarboxylase (HDC) inhibitor and HDC knockout all fail to compromise the protection by H3R blockade. H3R blockade inhibits mTOR phosphorylation and reinforces autophagy. The neuroprotection by H3R antagonism is reversed by 3-methyladenine and siRNA for Atg7, and is diminished in Atg5−/− mouse embryonic fibroblasts. Furthermore, the peptide Tat-H3RCT414-436, which blocks CLIC4 binding with H3Rs, or siRNA for CLIC4, further increases I/R-induced autophagy and protects against I/R injury. Therefore, H3R promotes I/R injury while its antagonism protects against ischaemic injury via histamine-independent mechanisms that involve suppressing H3R/CLIC4 binding-activated autophagy, suggesting that H3R inhibition is a therapeutic target for cerebral ischaemia. PMID:24566390

  19. Withdrawal of repeated morphine enhances histamine-induced scratching responses in mice.

    PubMed

    Abe, Kenji; Kobayashi, Kanayo; Yoshino, Saori; Taguchi, Kyoji; Nojima, Hiroshi

    2015-04-01

    An itch is experientially well known that the scratching response of conditions such as atopic dermatitis is enhanced under psychological stress. Morphine is typical narcotic drug that induces a scratching response upon local application as an adverse drug reaction. Although long-term treatment with morphine will cause tolerance and dependence, morphine withdrawal can cause psychologically and physiologically stressful changes in humans. In this study, we evaluated the effects of morphine withdrawal on histamine-induced scratching behavior in mice. Administration of morphine with progressively increasing doses (10-50 mg/kg, i.p.) was performed for 5 consecutive days. At 3, 24, 48, and 72 hr after spontaneous withdrawal from the final morphine dose, histamine was intradermally injected into the rostral part of the back and then the number of bouts of scratching in 60 min was recorded and summed. We found that at 24 hr after morphine withdrawal there was a significant increase in histamine-induced scratching behavior. The spinal c-Fos positive cells were also significantly increased. The relative adrenal weight increased and the relative thymus weight decreased, both significantly. Moreover, the plasma corticosterone levels changed in parallel with the number of scratching bouts. These results suggest that morphine withdrawal induces a stressed state and enhances in histamine-induced scratching behavior. Increased reaction against histamine in the cervical vertebrae will participate in this stress-induced itch enhancement.

  20. Proceedings of the 7th International Symposium on the Molecular Breeding of Forage and Turf

    USDA-ARS?s Scientific Manuscript database

    The 7th International Symposium on the Molecular Breeding of Forage and Turf, MBFT2012, was held in Salt Lake City, UT, USA, from 4-7 June 2012. One-hundred and fifteen researchers from around the world presented oral and poster formats relating to ten general topics: Genetic mechanisms and applic...

  1. Special Issue: 14th International Symposium on Novel and Nano Materials

    NASA Astrophysics Data System (ADS)

    Kim, Woo-Byoung; Choa, Yong-Ho; Ahn, Hyo-Jin; Park, Il-Kyu

    2017-09-01

    This Special Issue of Applied Surface Science is intended to provide a collection of peer-reviewed contributions presented at the 14th International Symposium on Novel Nano Materials (ISNNM) held in Budapest, Hungary as one of the most beautiful cities in Europe from July 3 to July 8, 2016. All selected papers underwent the regular peer review process as set by the journal of Applied Surface Science and its publisher (Elsevier).

  2. Overcoming barriers to ITS : lessons from other technologies : final task G report proceedings of the task G symposium

    DOT National Transportation Integrated Search

    1995-11-06

    This report summarizes the results of a small, one day symposium held on June 16, 1995 : in Washington D.C. as a part of the study being performed by the Urban Institute and its : subcontractors (Cambridge Systematics, Inc., Miller, Canfield, Paddock...

  3. Highlights from the IV International Symposium of Thrombosis and Anticoagulation (ISTA), October 20-21, 2011, Salvador, Bahia, Brazil.

    PubMed

    Lopes, Renato D; Becker, Richard C; Newby, L Kristin; Peterson, Eric D; Hylek, Elaine M; Granger, Christopher B; Crowther, Mark; Wang, Tracy; Carvalho, Antonio C; Berwanger, Otavio; Giraldez, Roberto R; Feitosa, Gilson Soares; Ribeiro, Jorge Pinto; Darze, Eduardo; Kalil, Renato A K; Andrande, Marianna; Boas, Fabio Villas; Andrade, Jadelson; Rocha, Ana Thereza; Harrington, Robert A; Lopes, Antonio C; Garcia, David A

    2012-07-01

    To discuss and share knowledge about advances in the care of patients with thrombotic disorders, the Fourth International Symposium of Thrombosis and Anticoagulation was held in Salvador, Bahia, Brazil, from October 20-21, 2011. This scientific program was developed by clinicians for clinicians and was promoted by three major clinical research institutes: the Brazilian Clinical Research Institute, the Duke Clinical Research Institute of the Duke University School of Medicine, and Hospital do Coração Research Institute. Comprising 2 days of academic presentations and open discussion, the symposium had as its primary goal to educate, motivate, and inspire internists, cardiologists, hematologists, and other physicians by convening national and international visionaries, thought-leaders, and dedicated clinician-scientists. This paper summarizes the symposium proceedings.

  4. Histamine prevents radiation-induced mesenchymal changes in breast cancer cells.

    PubMed

    Galarza, Tamara E; Mohamad, Nora A; Táquez Delgado, Mónica A; Vedoya, Guadalupe M; Crescenti, Ernesto J; Bergoc, Rosa M; Martín, Gabriela A; Cricco, Graciela P

    2016-09-01

    Radiotherapy is a prime option for treatment of solid tumors including breast cancer though side effects are usually present. Experimental evidence shows an increase in invasiveness of several neoplastic cell types through conventional tumor irradiation. The induction of epithelial to mesenchymal transition is proposed as an underlying cause of metastasis triggered by gamma irradiation. Experiments were conducted to investigate the role of histamine on the ionizing radiation-induced epithelial to mesenchymal transition events in breast cancer cells with different invasive phenotype. We also evaluated the potential involvement of Src phosphorylation in the migratory capability of irradiated cells upon histamine treatment. MCF-7 and MDA-MB-231 mammary tumor cells were exposed to a single dose of 2Gy of gamma radiation and five days after irradiation mesenchymal-like phenotypic changes were observed by optical microscope. The expression and subcellular localization of E-cadherin, β-catenin, vimentin and Slug were determined by immunoblot and indirect immunofluorescence. There was a decrease in the epithelial marker E-cadherin expression and an increase in the mesenchymal marker vimentin after irradiation. E-cadherin and β-catenin were mainly localized in cytoplasm. Slug positive nuclei, matrix metalloproteinase-2 activity and cell migration and invasion were significantly increased. In addition, a significant enhancement in Src phosphorylation/activation could be determined by immunoblot in irradiated cells. MCF-7 and MDA-MB-231 cells also received 1 or 20μM histamine during 24h previous to be irradiated. Notably, pre-treatment of breast cancer cells with 20μM histamine prevented the mesenchymal changes induced by ionizing radiation and also reduced the migratory behavior of irradiated cells decreasing phospho-Src levels. Collectively, our results suggest that histamine may block events related to epithelial to mesenchymal transition in irradiated mammary cancer

  5. The effects of substance P on histamine and 5-hydroxytryptamine release in the rat

    PubMed Central

    Fewtrell, C. M. S.; Foreman, J. C.; Jordan, C. C.; Oehme, P.; Renner, H.; Stewart, J. M.

    1982-01-01

    1. Substance P (SP) induces histamine release from isolated rat peritoneal mast cells at concentrations of 0·1-10 μM. 2. Inhibitors of glycolysis and oxidative phosphorylation prevent the release of histamine induced by SP. 3. Cells heated to 47 °C for 20 min release histamine when treated with an agent causing cell lysis but fail to release in response to SP. 4. SP does not release histamine by interacting with cell-bound IgE. 5. Histamine release by SP is rapid, with more than 90% of the response occurring within 1 min of the addition of the peptide to mast cells at 37 °C. 6. Substance P, unlike antigen—antibody or compound 48/80, does not show enhanced release of histamine when calcium (0·1-1 mM) is present in the extracellular medium but calcium increases the response to SP when the ion is added after the peptide. Extracellular calcium (0·1-1 mM), magnesium (1-10 mM) and cobalt (0·01-0·1 mM) all inhibit SP-induced histamine release when added before the peptide. Pre-treatment of the cells with EDTA (10 mM) and washing in calcium-free medium inhibits the histamine release induced by SP. 7. Histamine release induced by SP was optimum at an extracellular pH of 7·2. 8. A number of peptides structurally related to SP were examined for histamine-releasing activity. At the concentrations tested, the N-terminal dipeptides Lys-Pro and Arg-Pro, tuftsin, physalaemin, eledoisin, SP3-11, SP4-11 and [p-Glu6, p-amino Phe7]-SP6-11 were all found to be inactive. The relative activities of the other peptides were: [Formula: see text] 9. Rat basophilic leukaemia cells (RBL-2H3) fail to respond to SP at concentrations which activate rat mast cells. Release of 5-hydroxytryptamine by immunological activation of RBL cells is not changed by the presence of SP. 10. The mechanism of action of SP on mast cells and the nature of the SP receptor on mast cells is discussed in relation to SP receptors in other cell types. PMID:6184468

  6. PREFACE: Padjadjaran Earth Dialogues: International Symposium on Geophysical Issues, PEDISGI

    NASA Astrophysics Data System (ADS)

    Rosandi, Y.; Urbassek, H. M.; Yamanaka, H.

    2016-01-01

    This issue of IOP Conference Series: Earth and Environmental Science contains selected papers presented at the Padjadjaran Earth Dialogues: International Symposium on Geophysical Issues, PEDISGI. The meeting was held from June 8 to 10, 2015, at the Bale-Sawala of Universitas Padjadjaran in Jatinangor, Indonesia. The PEDISGI is a symposium to accommodate communication between researchers, in particular geophysicists and related scientists, and to enable sharing of knowledge and research findings concerning local and global geophysical issues. The symposium was attended by 126 participants and 64 contributors from Indonesian universities and the neighbouring countries in four categories, viz. Theoretical and Computational Geophysics, Environmental Geophysics, Geophysical Explorations, and Geophysical Instrumentations and Methods. The symposium was accompanied by a dialog, discussing a chosen topic regarding environmental and geological problems of relevance for the Indonesian archipelago and the surrounding regions. For this first event the topic was ''The formation of Bandung-Basin between myths and facts: Exemplary cultural, geological and geophysical study on the evolution of the earth surface'', presented by invited speakers and local experts. This activity was aimed at extending our knowledge on this particular subject, which may have global impact. This topic was augmented by theoretical background lectures on the earth's surface formation, presented by the invited speakers of the symposium. The meeting would not have been successful without the assistance of the local organizing committee. We want to specially thank Irwan A. Dharmawan for managing the programme, Anggie Susilawati and Mia U. Hasanah for the conference administration, and Dini Fitriani for financial management. We also thank the National Geographic Indonesia for its support via the Business to Business Collaboration Program. The conference photograph can be viewed in the PDF.

  7. Proceedings of the 2011 National Toxicology Program Satellite Symposium

    PubMed Central

    Boorman, Gary; Crabbs, Torrie A.; Kolenda-Roberts, Holly; Latimer, Ken; Miller, Andrew D.; Muravnick, Kathleen B.; Nyska, Abraham; Ochoa, Ricardo; Pardo, Ingrid D.; Ramot, Yuval; Rao, Deepa B.; Schuh, JoAnn; Suttie, Andrew; Travlos, Greg S.; Ward, Jerrold M.; Wolf, Jeffrey C.; Elmore, Susan A.

    2012-01-01

    The 2011 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri,” was held in Denver, Colorado in advance of the Society of Toxicologic Pathology’s 30th Annual Meeting. The goal of the NTP Symposium is to present current diagnostic pathology or nomenclature issues to the toxicologic pathology community. This article presents summaries of the speakers’ presentations, including diagnostic or nomenclature issues that were presented, along with select images that were used for audience voting or discussion. Some lesions and topics covered during the symposium include: proliferative lesions from various fish species including ameloblastoma, gas gland hyperplasia, nodular regenerative hepatocellular hyperplasia, and malignant granulosa cell tumor; spontaneous cystic hyperplasia in the stomach of CD1 mice and histiocytic aggregates in the duodenal villous tips of treated mice; an olfactory neuroblastoma in a cynomolgus monkey; various rodent skin lesions, including follicular parakeratotic hyperkeratosis, adnexal degeneration, and epithelial intracytoplasmic accumulations; oligodendroglioma and microgliomas in rats; a diagnostically challenging microcytic, hypochromic, responsive anemia in rats; a review of microcytes and microcytosis; nasal lesions associated with green tea extract and Ginkgo biloba in rats; corneal dystrophy in Dutch belted rabbits; valvulopathy in rats; and lymphoproliferative disease in a cynomolgus monkey. PMID:22089839

  8. Proceedings of the 2015 National Toxicology Program Satellite Symposium

    PubMed Central

    Elmore, Susan A.; Farman, Cindy A.; Hailey, James R.; Kovi, Ramesh C.; Malarkey, David E.; Morrison, James P.; Neel, Jennifer; Pesavento, Patricia A.; Porter, Brian F.; Szabo, Kathleen A.; Teixeira, Leandro B. C.; Quist, Erin M.

    2016-01-01

    The 2015 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri” was held in Minneapolis, Minnesota at the ACVP/ASVCP/STP combined meeting. The goal of this symposium is to present and discuss diagnostic pathology challenges or nomenclature issues. Because of the combined meeting, both laboratory and domestic animal cases were presented. This article presents summaries of the speakers’ talks, including challenging diagnostic cases or nomenclature issues that were presented, along with select images that were used for audience voting and discussion. Some lesions and topics covered during the symposium included hepatocellular lesions; a proposed harmonized diagnostic approach to rat cardiomyopathy; crop milk in a bird; avian feeding accoutrement; heat exchanger in a tuna; metastasis of a tobacco carcinogen-induced pulmonary carcinoma; neurocytoma in a rat; pituicytoma in a rat; rodent mammary gland whole mounts; dog and rat alveolar macrophage ultrastructure; dog and rat pulmonary phospholipidosis; alveolar macrophage aggregation in a dog; degenerating yeast in a cat liver aspirate; myeloid leukemia in lymph node aspirates from a dog; Trypanosoma cruzi in a dog; solanum toxicity in a cow; bovine astrovirus; malignant microglial tumor; and nomenclature challenges from the Special Senses International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) organ working group (OWG). PMID:27075180

  9. Preface to the Special Issue on TOUGH Symposium 2015

    NASA Astrophysics Data System (ADS)

    Blanco-Martín, Laura

    2017-11-01

    The TOUGH Symposium 2015 was held in Berkeley, California, September 28-30, 2015. The TOUGH family of codes, developed at the Energy Geosciences Division of Lawrence Berkeley National Laboratory (LBNL), is a suite of computer programs for the simulation of multiphase and multicomponent fluid and heat flows in porous and fractured media with applications in many geosciences fields, such as geothermal reservoir engineering, nuclear waste disposal, geological carbon sequestration, oil and gas reservoirs, gas hydrate research, vadose zone hydrology and environmental remediation. Since the first release in the 1980s, many modifications and enhancements have been continuously made to TOUGH and its various descendants (iTOUGH2, TOUGH+, TOUGH-MP, TOUGHREACT, TOUGH+HYDRATE, TMVOC...), at LBNL and elsewhere. Today, these codes are used worldwide in academia, government organizations and private companies in problems involving coupled hydrological, thermal, biogeochemical and geomechanical processes. The Symposia, organized every 2-3 years, bring together developers and users for an open exchange on recent code enhancements and applications. In 2015, the Symposium was attended by one hundred participants, representing thirty-four nationalities. This Special Issue in Computers & Geosciences gathers extended versions of selected Symposium proceedings related to (i) recent enhancements to the TOUGH family of codes and (ii) coupled flow and geomechanics processes modeling.

  10. Proceedings of the 2013 National Toxicology Program Satellite Symposium

    PubMed Central

    Elmore, Susan A.; Boyle, Michael C.; Boyle, Molly H.; Cora, Michelle C.; Crabbs, Torrie A.; Cummings, Connie A.; Gruebbel, Margarita M.; Johnson, Crystal L.; Malarkey, David E.; McInnes, Elizabeth F.; Nolte, Thomas; Shackelford, Cynthia C.; Ward, Jerrold M.

    2014-01-01

    The 2013 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri” was held in Portland, Oregon in advance of the Society of Toxicologic Pathology's 32nd annual meeting. The goal of the NTP Symposium is to present current diagnostic pathology or nomenclature issues to the toxicologic pathology community. This article presents summaries of the speakers' presentations, including diagnostic or nomenclature issues that were presented, along with select images that were used for audience voting and discussion. Some lesions and topics covered during the symposium included a caudal tail vertebra duplication in mice; nephroblastematosis in rats; ectopic C cell tumor in a hamster; granular cell aggregates/tumor in the uterus of a hamster; Pneumocystis carinii in the lung of a rat; iatrogenic chronic inflammation in the lungs of control rats; hepatoblastoma arising within an adenoma in a mouse; humoral hypercalcemia of benignancy in a transgenic mouse; acetaminophen induced hepatoxicity in rats; electron microscopy images of iatrogenic intraerythrocytic inclusions in transgenic mice; questionable hepatocellular degeneration/cell death/artifact in rats; atypical endometrial hyperplasia in rats; malignant mixed Müllerian tumors/carcinosarcomas in rats; differential diagnoses of proliferative lesions the intestine of rodents; and finally obstructive nephropathy caused by melamine poisoning in a rat. PMID:24334674

  11. Comparison of the effects of histamine and tolazoline on adenylate cyclase activity from guinea pig heart.

    PubMed

    Weinryb, I; Michel, I M

    1975-01-01

    Both histamine and tolazoline (2-benzyl-2-imidazoline) stimulated particulate fractions of adenylate cyclase from guinea pig myocardium. Tolazoline was one-tenth as potent, and about two-thirds as active at maximally effective levels, as was histamine. Enhancement of cyclase activity by tolazoline was additive with that by isoproterenol, and the histamine and tolazoline concentration-response curves were parallel, suggesting that tolazoline acted at the same site as histamine. At maximally effective concentrations, tolazoline did not affect ATPase or cyclic AMP phosphodiesterase activities associated with the cyclase preparations. The H1-receptor antagonist mepyramine, and the H2 antagonist, burimamide, blocked stimulation of cyclase by tolazoline at one-tenth the molarity of agonist. Both antagonists were less effective vs. histamine stimulation of heart cyclase in particulate fractions or whole homogenates, with mepyramine being generally more potent. It is suggested that the molecular basis of the stimulatory effect of tolazoline on cardiac tissue may be histaminergic stimulation of adenylate cyclase. Furthermore, the lack of potency of burimamide as a histamine antagonist and its lack of specificity compared to mepyramine, at the subcellular level, indicate that histamine-responsive adenylate cyclase from heart may not be a satisfactory molecular model for the H2 receptor pharmacology of histamine in cardiac tissue.

  12. [Performance evaluation of a fluorescamine-HPLC method for determination of histamine in fish and fish products].

    PubMed

    Kikuchi, Hiroyuki; Tsutsumi, Tomoaki; Matsuda, Rieko

    2012-01-01

    A method for the quantification of histamine in fish and fish products using tandem solid-phase extraction and fluorescence derivatization with fluorescamine was previously developed. In this study, we improved this analytical method to develop an official test method for quantification of histamine in fish and fish products, and performed a single laboratory study to validate it. Recovery tests of histamine from fillet (Thunnus obesus), and two fish products (fish sauce and salted and dried whole big-eye sardine) that were spiked at the level of 25 and 50 µg/g for T. obesus, and 50 and 100 µg/g for the two fish products, were carried out. The recoveries of histamine from the three samples tested were 88.8-99.6% with good repeatability (1.3-2.1%) and reproducibility (2.1-4.7%). Therefore, this method is acceptable for the quantification of histamine in fish and fish products. Moreover, surveillance of histamine content in food on the market was conducted using this method, and high levels of histamine were detected in some fish products.

  13. Fourth Symposium on Chemical Evolution and the Origin and Evolution of Life

    NASA Technical Reports Server (NTRS)

    Wharton, Robert A., Jr. (Editor); Andersen, Dale T. (Editor); Bzik, Sara E. (Editor); Rummel, John D. (Editor)

    1991-01-01

    This symposium was held at the NASA Ames Research Center, Moffett Field, California, July 24-27, 1990. The NASA exobiology investigators reported their recent research findings. Scientific papers were presented in the following areas: cosmic evolution of biogenic compounds, prebiotic evolution (planetary and molecular), early evolution of life (biological and geochemical), evolution of advanced life, solar system exploration, and the Search for Extraterrestrial Intelligence (SETI).

  14. A Nanoporous Alumina Membrane Based Electrochemical Biosensor for Histamine Determination with Biofunctionalized Magnetic Nanoparticles Concentration and Signal Amplification

    PubMed Central

    Ye, Weiwei; Xu, Yifan; Zheng, Lihao; Zhang, Yu; Yang, Mo; Sun, Peilong

    2016-01-01

    Histamine is an indicator of food quality and indispensable in the efficient functioning of various physiological systems. Rapid and sensitive determination of histamine is urgently needed in food analysis and clinical diagnostics. Traditional histamine detection methods require qualified personnel, need complex operation processes, and are time-consuming. In this study, a biofunctionalized nanoporous alumina membrane based electrochemical biosensor with magnetic nanoparticles (MNPs) concentration and signal amplification was developed for histamine determination. Nanoporous alumina membranes were modified by anti-histamine antibody and integrated into polydimethylsiloxane (PDMS) chambers. The specific antibody modified MNPs were used to concentrate histamine from samples and transferred to the antibody modified nanoporous membrane. The MNPs conjugated to histamine were captured in the nanopores via specific reaction between histamine and anti-histamine antibody, resulting in a blocking effect that was amplified by MNPs in the nanopores. The blockage signals could be measured by electrochemical impedance spectroscopy across the nanoporous alumina membrane. The sensing platform had great sensitivity and the limit of detection (LOD) reached as low as 3 nM. This biosensor could be successfully applied for histamine determination in saury that was stored in frozen conditions for different hours, presenting a potentially novel, sensitive, and specific sensing system for food quality assessment and safety support. PMID:27782087

  15. GROWTH AND DEVELOPMENT SYMPOSIUM: Understanding and mitigating the impacts of inflammation on animal growth and development

    USDA-ARS?s Scientific Manuscript database

    The Growth and Development Symposium titled “Understanding and mitigating the impacts of inflammation on animal growth and development” was held at the Joint Annual Meeting of the American Dairy Science Association and the American Society of Animal Science in New Orleans, LA, July 10 to 14, 2011. T...

  16. Highlights from the Tenth International Symposium of Thrombosis and Anticoagulation (ISTA X), September 22 and 23, 2017, Salvador, Bahia, Brazil.

    PubMed

    Lopes, Renato D; Guimarães, Patricia O; Crowther, Mark; Hylek, Elaine; Feitosa-Filho, Gilson S; Ritt, Luiz E; Filgueiras, Nivaldo; Garcia, David A

    2018-05-01

    To discuss and share knowledge about advances in the care of patients with thrombotic disorders, the Tenth International Symposium of Thrombosis and Anticoagulation was held in Salvador, Bahia, Brazil, on September 22 and 23, 2017. This scientific program was developed by clinicians for clinicians and was promoted by two major clinical research institutes-the Brazilian Clinical Research Institute and the Duke Clinical Research Institute of the Duke University School of Medicine. Comprising academic presentations and open discussion, the symposium had as its primary goal to educate, motivate, and inspire internists, cardiologists, hematologists, and other physicians by convening national and international visionaries, thought-leaders, and dedicated clinician-scientists. This paper summarizes the symposium proceedings.

  17. Report on the National Symposium on Personal Privacy and Information Technology (October 4-7, 1981).

    ERIC Educational Resources Information Center

    American Federation of Information Processing Societies, Montvale, NJ.

    A national symposium was held October 4-7, 1981, to explore the relationships among law, ethics, and informational technology as they relate to the individual's informational privacy. The introduction to this report describes the conference format; discusses the Privacy Act of 1974 and the Freedom of Information Act; and offers definitions of…

  18. The Third Air Force/NASA Symposium on Recent Advances in Multidisciplinary Analysis and Optimization

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The third Air Force/NASA Symposium on Recent Advances in Multidisciplinary Analysis and Optimization was held on 24-26 Sept. 1990. Sessions were on the following topics: dynamics and controls; multilevel optimization; sensitivity analysis; aerodynamic design software systems; optimization theory; analysis and design; shape optimization; vehicle components; structural optimization; aeroelasticity; artificial intelligence; multidisciplinary optimization; and composites.

  19. Proceedings of the Symposium on Needs for Nondestructive Testing in the Forest Products Industries

    Treesearch

    1965-01-01

    The purpose of this meeting was to bring together about 30 representatives of the various forest products industries and a few affiliated research and educational institutions to discuss and define industry needs for nondestructive testing. The necessity for such a meeting was made clear in the Symposium on Nondestructive Testing of Wood held at this Laboratory in...

  20. Proceedings of the seventh California oak symposium: managing oak woodlands in a dynamic world

    Treesearch

    Richard B. Standiford; Kathryn L. Purcell

    2015-01-01

    Beginning in 1979, there have been a series of symposia held every 5 to 7 years addressing the state of our knowledge about science, policy and management factors affecting California's oak resource. This program represents the seventh symposium in the series. California's oak woodlands cover 10 percent of the state, and in addition, are a key ecological...

  1. Histamine Induces Bovine Rumen Epithelial Cell Inflammatory Response via NF-κB Pathway.

    PubMed

    Sun, Xudong; Yuan, Xue; Chen, Liang; Wang, Tingting; Wang, Zhe; Sun, Guoquan; Li, Xiaobing; Li, Xinwei; Liu, Guowen

    2017-01-01

    Subacute ruminal acidosis (SARA) is a common disease in high-producing lactating cows. Rumenitis is the initial insult of SARA and is associated with the high concentrations of histamine produced in the rumen of dairy cows during SARA. However, the exact mechanism remains unclear. The objective of the current study is to investigate whether histamine induces inflammation of rumen epithelial cells and the underlying mechanism of this process. Bovine rumen epithelial cells were cultured and treated with different concentrations of histamine and pyrrolidine dithiocarbamate (PDTC, an NF-κB inhibitor) cultured in different pH medium (pH 7.2 or 5.5). qRT-PCR, Western-blotting, ELISA and immunocytofluorescence were used to evaluate whether histamine activated the NF-κB pathway and inflammatory cytokines. The results showed that histamine significantly increased the activity of IKK β and the phosphorylation levels of IκB α, as well as upregulated the mRNA and protein expression levels of NF-κB p65 in the rumen epithelial cells cultured in neutral (pH=7.2) and acidic (pH=5.5) medium. Furthermore, histamine treatment also significantly increased the transcriptional activity of NF-κB p65. High expression and transcriptional activity of NF-κB p65 significantly increased the mRNA expressions and concentrations of inflammatory cytokines, tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and interleukin 1 beta (IL-1β), thereby inducing the inflammatory response in bovine rumen epithelial cells. However, inhibition of NF-κB p65 by PDTC significantly decreased the expressions and concentrations of the inflammatory cytokines induced by histamine in the rumen epithelial cells cultured in the neutral and acidic medium. The present data indicate that histamine induces the inflammatory response of bovine rumen epithelial cells through the NF-κB pathway. © 2017 The Author(s). Published by S. Karger AG, Basel.

  2. Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forces.

    PubMed Central

    Moy, A B; Van Engelenhoven, J; Bodmer, J; Kamath, J; Keese, C; Giaever, I; Shasby, S; Shasby, D M

    1996-01-01

    We examined the contribution of actin-myosin contraction to the modulation of human umbilical vein endothelial cell focal adhesion caused by histamine and thrombin. Focal adhesion was measured as the electrical resistance across a cultured monolayer grown on a microelectrode. Actin-myosin contraction was measured as isometric tension of cultured monolayers grown on a collagen gel. Histamine immediately decreased electrical resistance but returned to basal levels within 3-5 min. Histamine did not increase isometric tension. Thrombin also immediately decreased electrical resistance, but, however, resistance did not return to basal levels for 40-60 min. Thrombin also increased isometric tension, ML-7, an inhibitor of myosin light chain kinase, prevented increases in myosin light chain phosphorylation and increases in tension development in cells exposed to thrombin. ML-7 did not prevent a decline in electrical resistance in cells exposed to thrombin. Instead, ML-7 restored the electrical resistance to basal levels in a shorter period of time (20 min) than cells exposed to thrombin alone. Also, histamine subsequently increased electrical resistance to above basal levels, and thrombin initiated an increase in resistance during the time of peak tension development. Hence, histamine and thrombin modulate endothelial cell focal adhesion through centripetal and centrifugal forces. PMID:8613524

  3. Comparison of analytical methods for the determination of histamine in reference canned fish samples

    NASA Astrophysics Data System (ADS)

    Jakšić, S.; Baloš, M. Ž.; Mihaljev, Ž.; Prodanov Radulović, J.; Nešić, K.

    2017-09-01

    Two screening methods for histamine in canned fish, an enzymatic test and a competitive direct enzyme-linked immunosorbent assay (CD-ELISA), were compared with the reversed-phase liquid chromatography (RP-HPLC) standard method. For enzymatic and CD-ELISA methods, determination was conducted according to producers’ manuals. For RP-HPLC, histamine was derivatized with dansyl-chloride, followed by RP-HPLC and diode array detection. Results of analysis of canned fish, supplied as reference samples for proficiency testing, showed good agreement when histamine was present at higher concentrations (above 100 mg kg-1). At a lower level (16.95 mg kg-1), the enzymatic test produced some higher results. Generally, analysis of four reference samples according to CD-ELISA and RP-HPLC showed good agreement for histamine determination (r=0.977 in concentration range 16.95-216 mg kg-1) The results show that the applied enzymatic test and CD-ELISA appeared to be suitable screening methods for the determination of histamine in canned fish.

  4. Symposium to Announce Finalists of NCI's "Up for a Challenge? Stimulating Innovation in Breast Cancer Genetic Epidemiology"

    Cancer.gov

    A symposium to announce the finalists of the Challenge was held on September 12, 2016, on the NIH main campus in Bethesda, MD. Finalists were chosen based on the identification of novel findings, replication of findings, innovation of approach, evidence of novel biological hypotheses, and collaboration.

  5. Inhibition of antibody synthesis by histamine in concanavalin A-treated mice: the possible role of glucocorticosteroids.

    PubMed

    Badger, A M; Griswold, D E; DiMartino, M J; Poste, G

    1982-09-01

    Administration of histamine (50 mg/kg) to BALB/C mice injected with concanavalin A (Con A) (100 micrograms, i.v.) 24 hr previously, results in a marked decrease in antibody synthesis to sheep red blood cells (SRBC) injected 2 hr later. This phenomenon occurs with nonimmunosuppressive doses of Con A and is strain-specific. It does not take place in the response to the T-independent antigen polyvinylpyrrolidone (PVP) or if histamine is administered after the antigen. Adoptive transfer of normal syngeneic cells at the same time as antigen does not reverse this effect. Excess suppressor cell generation was excluded by co-cultivation of treated spleen cells with normal cells in vitro and by determining their antibody response to SRBC 5 days later. 2-Methylhistamine, a histamine type 1 (H1) receptor agonist, mimicks the effect of histamine whereas dimaprit, a histamine type 2 (H2) receptor agonist, does not. Because histamine interaction with H1 receptors causes the release of adrenocorticotropic hormone (ACTH), we examined the effects of ACTH and corticosterone in this system and found that both could mimick the effect of histamine. These results suggest that the interaction of histamine with H1 receptors causes the release of glucocorticosteroids that may interfere with either Con A-activated T helper cell function or macrophage processing of T-dependent antigen.

  6. Modulation of genioglossus muscle activity across sleep-wake states by histamine at the hypoglossal motor pool.

    PubMed

    Bastedo, Timothy; Chan, Erin; Park, Eileen; Liu, Hattie; Horner, Richard L

    2009-10-01

    Histamine neurons comprise a major component of the aminergic arousal system and significantly influence sleep-wake states, with antihistamines widely used as sedative hypnotics. Unlike the serotonergic and noradrenergic components of this arousal system, however, the role of histamine in the central control of respiratory motor activity has not been determined. The aims of this study were to characterize the effects of histamine receptor agonists and antagonists at the hypoglossal motor pool on genioglossus muscle activity across sleep and awake states, and also determine if histamine contributes an endogenous excitatory drive to modulate hypoglossal motor outflow to genioglossus muscle. Thirty-three rats were implanted with electroencephalogram and neck electrodes to record sleep-wake states, and genioglossus and diaphragm electrodes for respiratory muscle recordings. Microdialysis probes were inserted into the hypoglossal motor nucleus. Histamine at the hypoglossal motor nucleus significantly increased tonic genioglossus muscle activity in wakefulness, non-REM sleep and REM sleep. The activating effects of histamine on genioglossus muscle activity also occurred with a histamine type-1 (H1) but not H2 receptor agonist. However, H1 receptor antagonism at the hypoglossal motor nucleus did not decrease genioglossus muscle activity in wakefulness or sleep. The results suggest that histamine at the hypoglossal motor pool increases genioglossus muscle activity in freely behaving rats in wakefulness, non-REM, and REM sleep via an H1 receptor mechanism.

  7. Isolation of histamine-producing Lactobacillus buchneri from Swiss cheese implicated in a food poisoning outbreak.

    PubMed Central

    Sumner, S S; Speckhard, M W; Somers, E B; Taylor, S L

    1985-01-01

    A histamine-producing strain of Lactobacillus buchneri was isolated from Swiss cheese that had been implicated in an outbreak of histamine poisoning. It produced up to 4,070 nmol of histamine per ml in MRS broth supplemented with 0.1% histidine. The identification of this isolate was based on its biochemical, bacteriological, and DNA characterizations. PMID:4083875

  8. Waste management in space: a NASA symposium. Special issue

    NASA Technical Reports Server (NTRS)

    Wydeven, T. (Principal Investigator)

    1991-01-01

    This special issue contains papers from the NASA Symposium on Waste Processing for Advanced Life Support, which was held at NASA Ames Research Center on September 11-13, 1990. Specialists in waste management from academia, government, and industry convened to exchange ideas and advise NASA in developing effective methods for waste management in a Controlled Ecological Life Support System (CELSS). Innovative and well-established methods were presented to assist in developing and managing wastes in closed systems for future long-duration space missions, especially missions to Mars.

  9. Liquid chromatographic determination of histamine in fish, sauerkraut, and wine: interlaboratory study.

    PubMed

    Beljaars, P R; Van Dijk, R; Jonker, K M; Schout, L J

    1998-01-01

    An interlaboratory study of the liquid chromatographic (LC) determination of histamine in fish, sauerkraut, and wine was conducted. Diminuted and homogenized samples were suspended in water followed by clarification of extracts with perchloric acid, filtration, and dilution with water. After LC separation on a reversed-phase C18 column with phosphate buffer (pH 3.0)--acetonitrile (875 + 125, v/v) as mobile phase, histamine was measured fluorometrically (excitation, 340 nm; emission, 455 nm) in samples and standards after postcolumn derivatization with o-phthaldialdehyde (OPA). Fourteen samples (including 6 blind duplicates and 1 split level) containing histamine at about 10-400 mg/kg or mg/L were analyzed singly according to the proposed procedure by 11 laboratories. Results from one participant were excluded from statistical analysis. For all samples analyzed, repeatability relative standard deviations varied from 2.1 to 5.6%, and reproducibility relative standard deviations ranged from 2.2 to 7.1%. Averaged recoveries of histamine for this concentration range varied from 94 to 100%.

  10. 3rd annual symposium of chemical and pharmaceutical structure analysis.

    PubMed

    Weng, Naidong; Zheng, Jenny; Lee, Mike

    2012-08-01

    The 3rd Annual Symposium on Chemical and Pharmaceutical Structure Analysis was once again held in Shanghai, where a rich history of 'East meets West' continued. This meeting is dedicated to bringing together scientists from pharmaceutical companies, academic institutes, CROs and instrument vendors to discuss current challenges and opportunities on the forefront of pharmaceutical research and development. The diversified symposia and roundtables are highly interactive events where scientists share their experiences and visions in a collegial setting. The symposium highlighted speakers and sessions that provided first-hand experiences as well as the latest guidance and industrial/regulatory thinking, which was reflected by the theme of this year's meeting 'From Bench to Decision Making - from Basics to Application.' In addition to the highly successful Young Scientist Excellence Award, new events were featured at this year's meeting, such as the Executive Roundtable and the inaugural Innovator Award.

  11. Assessment of the binding performance of histamine-imprinted microspheres by frontal analysis capillary electrophoresis.

    PubMed

    Romano, Edwin F; Quirino, Joselito P; Holdsworth, John L; So, Regina C; Holdsworth, Clovia I

    2017-05-01

    Frontal analysis capillary electrophoresis was used to evaluate the binding performance of molecularly imprinted microspheres (MIM) toward its template histamine and analogs at pH 7, and compared to the high performance liquid chromatographic method. In both methods, batch binding was employed and the binding parameters were calculated from the measured concentration of unbound amine analytes and afforded comparable histamine equilibrium dissociation constants (K d ∼ 0.4 mM). FACE was easily carried out at shorter binding equilibration time (i.e. 30 min) and without the need to separate the microspheres, circumventing laborious and, in the case of the system under study, inefficient sample filtration. It also allowed for competitive binding studies by virtue of its ability to distinctly separate intact microspheres and all tested amines which could not be resolved in HPLC. K d 's for nonimprinted (control) microspheres (NIM) from FACE and HPLC were also comparable (∼ 0.6 mM) but at higher histamine concentrations, HPLC gave lower histamine binding. This discrepancy was attributed to inefficient filtration of the batch binding samples prior to HPLC analysis resulting in an over-estimation of the concentration of free histamine brought about by the presence of unfiltered histamine-bound microspheres. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Highlights from the 2013 WIN Symposium: personalised cancer therapy from innovation to implementation.

    PubMed

    Schilsky, Richard L

    2013-01-01

    The Worldwide Innovative Networking (WIN) consortium is a global alliance of academic and industrial cancer researchers, clinicians, and cancer advocacy groups set up to promote innovations in personalised cancer therapy and to accelerate the translation of research in this discipline into the oncology clinic. One of its most important initiatives is the WIN symposia, which have been held in Paris each summer since 2009. The fifth WIN symposium, which was held 10-12 July 2013, took as its overall theme 'Personalised Cancer Therapy: From Innovation to Implementation'. Over 400 delegates, including a good number of representatives of patient groups as well as leading academic, industrial, and clinical scientists; students; and post-docs attended this symposium. Its scientific programme featured thirty presentations divided into four main plenary sessions, and there was also a wide-ranging poster session that encompassed all the topics covered in the plenaries. The programme structure followed the path of drug discovery, in that the first session covered assay development for personalised cancer medicine; the second, applications of genomics in oncology; the third, clinical development; and the fourth, the impact of personalised medicine on cancer care.

  13. Building Conservation Capacity in Southeast Asia: Outcomes of the ATBC 2015 Asia-Pacific Chapter Meeting Conservation Education Symposium

    ERIC Educational Resources Information Center

    Souter, Nicholas J.; Hughes, Alice C.; Savini, Tommaso; Rao, Madhu; Goodale, Eben; Van Nice, Amy; Huang, Natalia; Liu, Jing-Xin; Hunt, Matt P.; O'Connor, David A.; Heung-Lam, Anny Li; Gnuen, Gneb; Sun, Yoeung; Silva, Inês

    2017-01-01

    The "Building Capacity for Conservation in Southeast Asia" symposium was held at the 2015 Association for Tropical Biology and Conservation, Asia-Pacific Chapter meeting. The range of programs discussed fell into three categories: career development, project-specific activities and outreach, and delivering conservation information to…

  14. Label-free histamine detection with nanofluidic diodes through metal ion displacement mechanism.

    PubMed

    Ali, Mubarak; Ramirez, Patricio; Duznovic, Ivana; Nasir, Saima; Mafe, Salvador; Ensinger, Wolfgang

    2017-02-01

    We design and characterize a nanofluidic device for the label-free specific detection of histamine neurotransmitter based on a metal ion displacement mechanism. The sensor consists of an asymmetric polymer nanopore fabricated via ion track-etching technique. The nanopore sensor surface having metal-nitrilotriacetic (NTA-Ni 2+ ) chelates is obtained by covalent coupling of native carboxylic acid groups with N α ,N α -bis(carboxymethyl)-l-lysine (BCML), followed by exposure to Ni 2+ ion solution. The BCML immobilization and subsequent Ni 2+ ion complexation with NTA moieties change the surface charge concentration, which has a significant impact on the current-voltage (I-V) curve after chemical modification of the nanopore. The sensing mechanism is based on the displacement of the metal ion from the NTA-Ni 2+ chelates. When the modified pore is exposed to histamine solution, the Ni 2+ ion in NTA-Ni 2+ chelate recognizes histamine through a metal ion coordination displacement process and formation of stable Ni-histamine complexes, leading to the regeneration of metal-free NTA groups on the pore surface, as shown in the current-voltage characteristics. Nanomolar concentrations of the histamine in the working electrolyte can be detected. On the contrary, other neurotransmitters such as glycine, serotonin, gamma-aminobutyric acid, and dopamine do not provoke significant changes in the nanopore electronic signal due to their inability to displace the metal ion and form a stable complex with Ni 2+ ion. The nanofluidic sensor exhibits high sensitivity, specificity and reusability towards histamine detection and can then be used to monitor the concentration of biological important neurotransmitters. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430

    PubMed Central

    Lim, Herman D; Adami, Maristella; Guaita, Elena; Werfel, Thomas; Smits, Rogier A; de Esch, Iwan JP; Bakker, Remko A; Gutzmer, Ralf; Coruzzi, Gabriella; Leurs, Rob

    2009-01-01

    Background and purpose: We compare the pharmacological profiles of a new histamine H4 receptor agonist 2-(2-guanidinoethyl)isothiourea (VUF 8430) with that of a previously described H4 receptor agonist, 4-methylhistamine. Experimental approach: Radioligand binding and functional assays were performed using histamine H4 receptors expressed in mammalian cell lines. Compounds were also evaluated ex vivo in monocyte-derived dendritic cells endogenously expressing H4 receptors and in vivo in anaesthetized rats for gastric acid secretion activity. Key results: Both VUF 8430 and 4-methylhistamine were full agonists at human H4 receptors with lower affinity at rat and mouse H4 receptors. Both compounds induced chemotaxis of monocyte-derived dendritic cells. VUF 8430 also showed reasonable affinity and was a full agonist at the H3 receptor. Agmatine is a metabolite of arginine, structurally related to VUF 8430, and was a H4 receptor agonist with micromolar affinity. At histamine H3 receptors, agmatine was a full agonist, whereas 4-methylhistamine was an agonist only at high concentrations. Both VUF 8430 and agmatine were inactive at H1 and H2 receptors, whereas 4-methylhistamine is as active as histamine at H2 receptors. In vivo, VUF 8430 only caused a weak secretion of gastric acid mediated by H2 receptors, whereas 4-methylhistamine, dimaprit, histamine and amthamine, at equimolar doses, induced 2.5- to 6-fold higher output than VUF 8430. Conclusions and implications: Our results suggest complementary use of 4-methylhistamine and VUF 8430 as H4 receptor agonists. Along with H4 receptor antagonists, both agonists can serve as useful pharmacological tools in studies of histamine H4 receptors. PMID:19413569

  16. N-(4-Trifluoromethylphenyl)amide group of the synthetic histamine receptor agonist inhibits nicotinic acetylcholine receptor-mediated catecholamine secretion.

    PubMed

    Kim, Dong-Chan; Park, Yong-Soo; Jun, Dong-Jae; Hur, Eun-Mi; Kim, Sun-Hee; Choi, Bo-Hwa; Kim, Kyong-Tai

    2006-02-28

    The therapeutic targeting of nicotinic receptors requires the identification of drugs that selectively activate or inhibit a limited range of nicotine acetylcholine receptors (nAChRs). In this study, we identified N-(4-trifluoromethylphenyl)amide group of the synthetic histamine receptor ligands, histamine-trifluoromethyltoluide, that act as potent inhibitors of nAChRs in bovine adrenal chromaffin cells. Catecholamine secretion induced by the nAChRs agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), was significantly inhibited by histamine-trifluoromethyltoluide. Real time carbon-fiber amperometry confirmed the ability of histamine-trifluoromethyltoluide to inhibit DMPP-induced exocytosis in single chromaffin cells. We also found that histamine-trifluoromethyltoluide inhibited DMPP-induced [Ca(2+)](i) and [Na(+)](i) increases, as well as DMPP-induced inward currents in the absence of extracellular calcium. Histamine-trifluoromethyltoluide had no effect on [(3)H]nicotine binding or on calcium increases induced by high K(+), bradykinin, veratridine, histamine, and benzoylbenzoyl ATP. Among the synthetic histamine receptor ligands, clobenpropit exhibited similarity. In addition, 4'-nitroacetanilide also significantly attenuated nAChR-mediated catecholamine secretion. In conclusion, the N-(4-trifluoromethylphenyl)amide group of the histamine-trifluoromethyltoluide might be the critical moiety in the inhibition of nAChR-mediated CA secretion.

  17. Interaction between histamine and dichloroisoproterenol, hexamethonium, pempidine, and diphenhydramine, in normal and reserpine-treated heart preparations

    PubMed Central

    Mannaioni, P. F.

    1960-01-01

    Histamine stimulated the isolated auricles and heart of the guinea-pig. The effect was best seen in auricles which had been previously depressed by treatment with reserpine. Ganglionic blocking drugs (hexamethonium and pempidine), applied to auricles which had been previously treated with reserpine, abolished the diphasic effect of nicotine, but did not alter the response to histamine. Dichloroisoproterenol did not modify the stimulant action of histamine in isolated auricles, either before or after treatment with reserpine; nor did it alter the response of the isolated heart. Diphenhydramine reduced or blocked the stimulant action of histamine in auricles which had been previously treated with reserpine. The results support the hypothesis that histamine stimulates the myocardium by a direct action on specific receptors. PMID:13766225

  18. Managing fine hardwoods after a half century of research: Proceedings of the Seventh Walnut Council Research Symposium

    Treesearch

    J.W. Van Sambeek; Elizabeth A. Jackson; Mark V. Coggeshall; Andrew L. Thomas; Charles H. eds. Michler

    2013-01-01

    This report presents information from the Seventh Walnut Council Research Symposium, held August 1-3, 2011. This report includes 14 papers and abstracts relating to economics and utilization, pest management, nursery production, plantation establishment, tree improvement, stand management, agroforestry, and nut production of black walnut, related Juglans species, and...

  19. Physiology and Endocrinology Symposium: The current status of heat shock in early embryonic survival and reproductive efficiency

    USDA-ARS?s Scientific Manuscript database

    The Physiology and Endocrinology Symposium entitled “The Current Status of Heat Shock in Early Embryonic Survival and Reproductive Efficiency” was held at the Joint ADSA-CSAS-AMPA-WSAS-ASAS Meeting in Phoenix, Arizona, July 15 to 19, 2012. In recent years, data has accumulated suggesting a role for...

  20. PREFACE: High Performance Computing Symposium 2011

    NASA Astrophysics Data System (ADS)

    Talon, Suzanne; Mousseau, Normand; Peslherbe, Gilles; Bertrand, François; Gauthier, Pierre; Kadem, Lyes; Moitessier, Nicolas; Rouleau, Guy; Wittig, Rod

    2012-02-01

    HPCS (High Performance Computing Symposium) is a multidisciplinary conference that focuses on research involving High Performance Computing and its application. Attended by Canadian and international experts and renowned researchers in the sciences, all areas of engineering, the applied sciences, medicine and life sciences, mathematics, the humanities and social sciences, it is Canada's pre-eminent forum for HPC. The 25th edition was held in Montréal, at the Université du Québec à Montréal, from 15-17 June and focused on HPC in Medical Science. The conference was preceded by tutorials held at Concordia University, where 56 participants learned about HPC best practices, GPU computing, parallel computing, debugging and a number of high-level languages. 274 participants from six countries attended the main conference, which involved 11 invited and 37 contributed oral presentations, 33 posters, and an exhibit hall with 16 booths from our sponsors. The work that follows is a collection of papers presented at the conference covering HPC topics ranging from computer science to bioinformatics. They are divided here into four sections: HPC in Engineering, Physics and Materials Science, HPC in Medical Science, HPC Enabling to Explore our World and New Algorithms for HPC. We would once more like to thank the participants and invited speakers, the members of the Scientific Committee, the referees who spent time reviewing the papers and our invaluable sponsors. To hear the invited talks and learn about 25 years of HPC development in Canada visit the Symposium website: http://2011.hpcs.ca/lang/en/conference/keynote-speakers/ Enjoy the excellent papers that follow, and we look forward to seeing you in Vancouver for HPCS 2012! Gilles Peslherbe Chair of the Scientific Committee Normand Mousseau Co-Chair of HPCS 2011 Suzanne Talon Chair of the Organizing Committee UQAM Sponsors The PDF also contains photographs from the conference banquet.

  1. Proceedings of the 22nd Texas Symposium On Relativistic Astrophysics At Stanford University

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chen, P.,; Bloom, Elliott D.,; Madejski, G.,

    2005-09-19

    The XXII Texas Symposium on Relativistic Astrophysics, jointly organized by the Kavli Institute for Particle Astrophysics and Cosmology (KIPAC), the Stanford Linear Accelerator Center, and the Physics Department of Stanford University, was held on December 13-17, 2004. Following the tradition of past Texas Symposia the presentations emphasized recent developments in Cosmology, High Energy Astrophysics and the frontiers between these and Gravitation and Particle Physics.

  2. Summary Report of the First International Symposium on Strain Gauge Balances and Workshop on AoA/Model Deformation Measurement Techniques

    NASA Technical Reports Server (NTRS)

    Tripp, John S.; Tcheng, Ping; Burner, Alpheus W.; Finley, Tom D.

    1999-01-01

    The first International Symposium on Strain Gauge Balances was sponsored under the auspices of the NASA Langley Research Center (LaRC), Hampton, Virginia during October 22-25, 1996. Held at the LaRC Reid Conference Center, the Symposium provided an open international forum for presentation, discussion, and exchange of technical information among wind tunnel test technique specialists and strain gauge balance designers. The Symposium also served to initiate organized professional activities among the participating and relevant international technical communities. The program included a panel discussion, technical paper sessions, tours of local facilities, and vendor exhibits. Over 130 delegates were in attendance from 15 countries. A steering committee was formed to plan a second international balance symposium tentatively scheduled to be hosted in the United Kingdom in 1998 or 1999. The Balance Symposium was followed by the half-day Workshop on Angle of Attack and Model Deformation on the afternoon of October 25. The thrust of the Workshop was to assess the state of the art in angle of attack (AoA) and model deformation measurement techniques and to discuss future developments.

  3. A Crisis of Lost Opportunity--Conclusions from a Symposium on Challenges for Animal Population Health Education.

    ERIC Educational Resources Information Center

    Hird, David; King, Lonnie; Salman, Mo; Werge, Rob

    2002-01-01

    Describes a symposium on "Population Health Education" held at the University of California Davis on May 9-11, 2002. Its objectives were to assess the market needs and opportunities presented by the users of population medicine veterinarians, determine the degree to which veterinary colleges are producing professionals who meet these needs,…

  4. Birth of a Neurogastronomy Nation: The Inaugural Symposium of the International Society of Neurogastronomy.

    PubMed

    Herz, Rachel S

    2016-02-01

    A review of the neuroscientific, clinical medicine, culinary, and food technology and agriculture presentations and demonstrations that were featured at the inaugural symposium of the International Society of Neurogastronomy, held at the University of Kentucky on November 7, 2015. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  5. Histamine-producing Lactobacillus parabuchneri strains isolated from grated cheese can form biofilms on stainless steel.

    PubMed

    Diaz, Maria; Del Rio, Beatriz; Sanchez-Llana, Esther; Ladero, Victor; Redruello, Begoña; Fernández, María; Martin, M Cruz; Alvarez, Miguel A

    2016-10-01

    The consumption of food containing large amounts of histamine can lead to histamine poisoning. Cheese is one of the most frequently involved foods. Histamine, one of the biogenic amines (BAs) exhibiting the highest safety risk, accumulates in food contaminated by microorganisms with histidine decarboxylase activity. The origin of these microorganisms may be very diverse with contamination likely occurring during post-ripening processing, but the microorganisms involved during this manufacturing step have never been identified. The present work reports the isolation of 21 histamine-producing Lactobacillus parabuchneri strains from a histamine-containing grated cheese. PCR revealed that every isolate carried the histidine decarboxylase gene (hdcA). Eight lineages were identified based on the results of genome PFGE restriction analysis plus endonuclease restriction profile analysis of the carried plasmids. Members of all lineages were able to form biofilms on polystyrene and stainless steel surfaces. L. parabuchneri is therefore an undesirable species in the dairy industry; the biofilms it can produce on food processing equipment represent a reservoir of histamine-producing bacteria and thus a source of contamination of post-ripening-processed cheeses. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Bringing global cancer leaders together at the 4th Annual Symposium on Global Cancer Research

    Cancer.gov

    The Annual Symposium on Global Cancer Research held in April 2016 was developed with a special focus on innovative and low-cost technologies in global cancer control, and brought inspiring keynote speakers such as John Seffrin, Former CEO of the American Cancer Society, and Tom Bollyky, Senior Fellow for Global Health at the Council on Foreign Relations.

  7. International Symposium on Internationalization and Foreign Students Problems. Proceedings (Kobe, Japan, October 29-30, 1990).

    ERIC Educational Resources Information Center

    Kobe Univ., (Japan).

    The meeting reported here was held to address the issues related to the increasing numbers of foreign students in Japan (31,000 in 1989 and increasing annually by 20%). First, profiles of the speakers and the texts of their speeches are presented, as well as the comments made during the panel discussions and symposium sessions. Speakers from 11…

  8. Heat resistance of histamine-producing bacteria in irradiated tuna loins.

    PubMed

    Enache, Elena; Kataoka, Ai; Black, D Glenn; Weddig, Lisa; Hayman, Melinda; Bjornsdottir-Butler, Kristin

    2013-09-01

    Consumption of foods high in biogenic amines leads to an illness known as histamine, or scombrotoxin, poisoning. The illness is commonly associated with consumption of fish with high levels of histamine ( $ 500 ppm). The objective of this study was to determine and compare the heat resistance of five histamine-producing bacteria in irradiated albacore tuna loins. Heat-resistance parameters (D- and z-values) were determined for Morganella morganii, Raoultella planticola, Hafnia alvei, and Enterobacter aerogenes. D- or z-values were not determined for Photobacterium damselae, which was the most heat-sensitive organism in this study. P. damselae declined > 5.9 log CFU/g after a heat treatment of 50°C for 10 min, 54°C for 3 min, and 56°C for 0.5 min. M. morganii was the most heat-resistant histamine-producing bacteria in albacore tuna loins, followed by E. aerogenes, H. alvei, and R. planticola. M. morganii and E. aerogenes had the highest D(50°C), 49.7 ± 17.57 and 51.8 ± 17.38 min, respectively. In addition, M. morganii had the highest D-values for all other temperatures (54, 56, and 58°C) tested. D- and zvalues were also determined for M. morganii in skipjack tuna. While no significant (P > 0.05) difference was observed between D(54°C) and D(56°C) of M. morganii in either albacore or skipjack tuna, the D(58°C) (0.4 ± 0.17 min) was significantly lower (P < 0.05) in skipjack than in albacore (0.9 ± 0.24 min). The z-values for all organisms tested were in the range of 3.2 to 3.8°C. This study suggests that heat treatment designed to control M. morganii in tuna loins is sufficient for controlling histamine-producing bacteria in canned-tuna processing environments.

  9. Histamine poisoning from insect consumption: an outbreak investigation from Thailand.

    PubMed

    Chomchai, Summon; Chomchai, Chulathida

    2018-02-01

    Insect consumption is a common practice in the Asian culture and all over the world. We are reporting an outbreak investigation of histamine poisoning from ingestion of fried insects. On 24 July 2014, a group of students at a seminar presented to Angthong Provincial Hospital, Thailand, with pruritic rash after ingesting snacks consisting of fried insects from a vendor. We initiated an outbreak investigation with retrospective cohort design and collected samples of remaining foods for analyses. Attack rates, relative risks and their confidence intervals (CI) were calculated. Out of 227 students, 28 developed illnesses that were consistent with our case definition which included, flushing, pruritus, urticarial rashes, headache, nausea, vomiting, diarrhea, dyspnea and bronchospasm. Two children were hospitalized for progressive bronchospasm overnight without serious complications. The types of food ingested included a lunch that was provided at the seminar for all students and snacks that 41 students bought from the only vendor in the vicinity. The snacks included fried grasshoppers, silkworm pupae, common green frogs, bamboo borers, crickets and meat balls. The attack rates were highest (82.6 and 85.0%) among students who ingested fried grasshoppers and silkworm pupae and lowest (4.4 and 5.3%) among those who did not ingest them, with relative risk of 18.7 (95% CI 9.6-36.4) for grasshoppers and 16.0 (95% CI 8.8-29.3) for silkworm pupae. Histamine concentrations in the fried grasshoppers and silkworm pupae were 9.73 and 7.66 mg/100g, respectively. Through epidemiological analysis and laboratory confirmation, we have illustrated that histamine poisoning can occur from ingestion of fried insects. We postulate that histidine, which is present in high concentration in grasshoppers and silkworm pupae, is decarboxylated by bacteria to histamine, a heat stable toxin. The ingestion of histamine is responsible for the clinical pictures being reported.

  10. LHC Nobel Symposium Proceedings

    NASA Astrophysics Data System (ADS)

    Ekelöf, Tord

    2013-12-01

    In the summer of 2012, a great discovery emerged at the Large Hadron Collider (LHC) at CERN in Geneva. A plethora of new precision data had already by then been collected by the ATLAS and CMS experiments at LHC, providing further extensive support for the validity of the Standard Model of particle physics. But what now appeared was the first evidence for what was not only the last unverified prediction of the Standard Model, but also perhaps the most decisive one: the prediction made already in 1964 of a unique scalar boson required by the theory of François Englert and Peter Higgs on how fundamental particles acquire mass. At that moment in 2012, it seemed particularly appropriate to start planning a gathering of world experts in particle physics to take stock of the situation and try to answer the challenging question: what next? By May 2013, when the LHC Nobel Symposium was held at the Krusenberg Mansion outside Uppsala in Sweden, the first signs of a great discovery had already turned into fully convincing experimental evidence for the existence of a scalar boson of mass about 125 GeV, having properties compatible with the 50-year-old prediction. And in October 2013, the evidence was deemed so convincing that the Swedish Royal Academy of Sciences awarded the Nobel Prize in Physics to Englert and Higgs for their pioneering work. At the same time the search at the LHC for other particles, beyond those predicted by the Standard Model, with heavier masses up to—and in some cases beyond—1 TeV, had provided no positive result. The triumph of the Standard Model seems resounding, in particular because the mass of the discovered scalar boson is such that, when identified with the Higgs boson, the Standard Model is able to provide predictions at energies as high as the Planck mass, although at the price of accepting that the vacuum would be metastable. However, even if there were some feelings of triumph, the ambience at the LHC Nobel Symposium was more one of

  11. PATRAM '92: 10th international symposium on the packaging and transportation of radioactive materials [Papers presented by Sandia National Laboratories

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    This document provides the papers presented by Sandia Laboratories at PATRAM '92, the tenth International symposium on the Packaging and Transportation of Radioactive Materials held September 13--18, 1992 in Yokohama City, Japan. Individual papers have been cataloged separately. (FL)

  12. Endothelial cell-dependent relaxation and contraction induced by histamine in the isolated guinea-pig pulmonary artery.

    PubMed

    Satoh, H; Inui, J

    1984-01-27

    Histamine (10(-8)-10(-6) M) relaxed in a concentration-dependent manner the guinea-pig pulmonary artery which had been contracted by noradrenaline (5 X 10(-7) M). After the removal of endothelial cells (ETCs) histamine at the same concentrations did not cause relaxation but induced additional contraction. Both responses to histamine were antagonized by chlorpheniramine (3 X 10(-7) M). These results suggest that in the pulmonary artery histamine simultaneously stimulates H1-receptors located on both ETCs and smooth muscle cells. This results in two opposite effects, relaxation mediated by ETCs, and contraction.

  13. Case Studies in Regional Energy Planning. Papers presented at a symposium at the Annual Meeting of the American Association for the Advancement of Science (142nd, Boston, Massachusetts, February 18-24, 1976).

    ERIC Educational Resources Information Center

    Blanpied, William A., Ed.; Vermilye, Gretchen, Ed.

    The papers reproduced in this collection were originally prepared for presentation at a February 1976 symposium at the annual meeting of the American Association for the Advancement of Science. The symposium summarized a series of three regional seminars on National Energy Policy in a Regional Context; these seminars were held in Minnesota, New…

  14. 10. Freiburger Symposium 2011 der SCG-Division Industrielle Chemie Technology Progress, Success Key for our Production Sites.

    PubMed

    Naef, Olivier

    2012-01-01

    This short paper presents the abstracts of the different presentations during 10. Freiburger Symposium 2011 der SCG-Division Industrielle Chemie: Technology Progress, Success key for our production sites held Thursday and Friday, September 29 and 30, 2011 at the Ecole d'ingénieurs et d'architectes de Fribourg (Switzerland).

  15. Proceedings of the 2015 National Toxicology Program Satellite Symposium.

    PubMed

    Elmore, Susan A; Farman, Cindy A; Hailey, James R; Kovi, Ramesh C; Malarkey, David E; Morrison, James P; Neel, Jennifer; Pesavento, Patricia A; Porter, Brian F; Szabo, Kathleen A; Teixeira, Leandro B C; Quist, Erin M

    2016-06-01

    The 2015 Annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri" was held in Minneapolis, Minnesota, at the American College of Veterinary Pathologists/American Society for Veterinary Clinical Pathology/Society of Toxicologic Pathology combined meeting. The goal of this symposium is to present and discuss diagnostic pathology challenges or nomenclature issues. Because of the combined meeting, both laboratory and domestic animal cases were presented. This article presents summaries of the speakers' talks, including challenging diagnostic cases or nomenclature issues that were presented, along with select images that were used for audience voting and discussion. Some lesions and topics covered during the symposium included hepatocellular lesions, a proposed harmonized diagnostic approach to rat cardiomyopathy, crop milk in a bird, avian feeding accoutrement, heat exchanger in a tuna, metastasis of a tobacco carcinogen-induced pulmonary carcinoma, neurocytoma in a rat, pituicytoma in a rat, rodent mammary gland whole mounts, dog and rat alveolar macrophage ultrastructure, dog and rat pulmonary phospholipidosis, alveolar macrophage aggregation in a dog, degenerating yeast in a cat liver aspirate, myeloid leukemia in lymph node aspirates from a dog, Trypanosoma cruzi in a dog, solanum toxicity in a cow, bovine astrovirus, malignant microglial tumor, and nomenclature challenges from the Special Senses International Harmonization of Nomenclature and Diagnostic Criteria Organ Working Group. © The Author(s) 2016.

  16. Proceedings of the 2014 National Toxicology Program Satellite Symposium

    PubMed Central

    Elmore, Susan A.; Cora, Michelle C.; Gruebbel, Margarita M.; Hayes, Schantel A.; Hoane, Jessica S.; Koizumi, Haruko; Peters, Rachel; Rosol, Thomas J.; Singh, Bhanu P.; Szabo, Kathleen A.

    2014-01-01

    The 2014 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri” was held in Washington DC, in advance of the Society of Toxicologic Pathology’s 33rd annual meeting. The goal of this annual NTP Symposium is to present current diagnostic pathology or nomenclature issues to the toxicologic pathology community. This article presents summaries of the speakers’ presentations, including diagnostic or nomenclature issues that were presented, along with select images that were used for audience voting and discussion. Some lesions and topics covered during the symposium included a pulmonary mucinous adenocarcinoma in a male B6C3F1 mouse; plexiform vasculopathy in Wistar Han rats; staging of the estrous cycle in rats and mice; peri-islet fibrosis, hemorrhage, lobular atrophy and inflammation in male Sprague Dawley rats; retinal dysplasia in Wistar Han rats and B6C3F1 mice; multicentric lymphoma with intravascular microemboli and tumor lysis syndrome, and two cases of myopathy and vascular anomaly in Tg.rasH2 mice; benign thymomas in Wistar Han rats; angiomatous lesions in the mesenteric lymph nodes of Wistar Han rats; an unusual foveal lesion in a cynomolgous monkey; and finally a series of nomenclatures challenges from the endocrine International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) organ working group (OWG). PMID:25385331

  17. IGE AND IGGA ANTIBODY-MEDIATED RELEASE OF HISTAMINE FROM RAT PERITONEAL CELLS

    PubMed Central

    Bach, Michael K.; Bloch, Kurt J.; Austen, K. Frank

    1971-01-01

    IgGa, in contrast to IgE, antibodies mediated the antigen-induced release of histamine from rat peritoneal mast cells without a requirement for a latent period and without the capacity to bind firmly to the target cell. Nonetheless, IgGa anti-DNP antibody interfered with the capacity of rat anti-N. brasiliensis antiserum rich in IgE antibodies to prepare the target cells for histamine release by worm antigen. Further, interaction of IgE antibody-prepared cells with IgGa anti-DNP antibody and DNP-BSA at 0°C so as to achieve sterile activation, or at 30°C to permit histamine release, inactivated such cells as determined by the subsequent failure to release histamine upon challenge with worm antigen. Thus, although IgE and IgGa antibodies are immunochemically distinct homologous immunoglobulins and exhibit different functional characteristics, their interaction at the target cell involves a common receptor and at least one common point in the pathway to the release of pharmacologic agents from the cell. PMID:4101607

  18. Effects of antidepressant drugs on histamine-H/sub 1/ receptors in the brain

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hall, H.; Oegren, S.O.

    1984-02-06

    The histamine-H/sub 1/ receptor blocking properties of a number of structurally different antidepressant drugs have been evaluated using a /sup 3/H-mepyramine binding assay and a guinea-pig ileum preparation. The tricyclic antidepressants all inhibited the histamine-H/sub 1/ receptor. Some newer antidepressant drugs, such as zimeldine and nomifensine were devoid of activity while others, such as iprindole and mianserin were very potent. It is concluded that antagonistic effects on the histamine-H/sub 1/ receptor is not associated with the therapeutic efficacy in depression, but may contribute to the sedative effects of the antidepressant drugs.

  19. Knowledge for the future of black walnut; proceedings of the 5th black walnut symposium; 1996 July 28-31; Springfield, MO.

    Treesearch

    J.W. Van Sambeek

    1997-01-01

    Proceedings of the Fifth Black Walnut Symposium held 28-31 July 1996 in Springfield, Missouri. Includes 46 manuscripts and abstracts dealing with establishment, management, and utilization of black walnut with emphasis on increased use for agroforestry and nut culture.

  20. Proceedings of the 8th International Symposium on Remote Sensing of Environment, volume 1

    NASA Technical Reports Server (NTRS)

    Cook, J. J.

    1972-01-01

    These Proceedings contain papers presented at the Eighth International Symposium on Remote Sensing of Environment, held October 2nd through 6th, 1972, on the campus of the University of Michigan. The symposium was conducted by the Center for Remote Sensing Information and Analysis of the Environmental Research Institute of Michigan (formerly the University of Michigan's Willow Run Laboratories) as a part of a continuing program investigating current activities in the field of remote sensing. Presentations include those on the use of this technology by regional governmental units and by federal governmental agencies, as well as various applications in monitoring and managing the earth's resources and man's global environment. Ground-based, airborne, and spaceborne sensor systems and manual and machine-assisted data analysis and interpretation are included.

  1. Kv4.2 Mediates Histamine Modulation of Preoptic Neuron Activity and Body Temperature

    PubMed Central

    Sethi, Jasmine; Sanchez-Alavez, Manuel; Tabarean, Iustin V.

    2011-01-01

    Histamine regulates arousal, circadian rhythms, and thermoregulation. Activation of H3 histamine receptors expressed by preoptic GABAergic neurons results in a decrease of their firing rate and hyperthermia. Here we report that an increase in the A-type K+ current in preoptic GABAergic neurons in response to activation of H3 histamine receptors results in decreased firing rate and hyperthermia in mice. The Kv4.2 subunit is required for these actions in spite of the fact that Kv4.2−/− preoptic GABAergic neurons display A-type currents and firing characteristics similar to those of wild-type neurons. This electrical remodeling is achieved by robust upregulation of the expression of the Kv4.1 subunit and of a delayed rectifier current. Dynamic clamp experiments indicate that enhancement of the A-type current by a similar amount to that induced by histamine is sufficient to mimic its robust effect on firing rates. These data indicate a central role played by the Kv4.2 subunit in histamine regulation of body temperature and its interaction with pERK1/2 downstream of the H3 receptor. We also reveal that this pathway provides a mechanism for selective modulation of body temperature at the beginning of the active phase of the circadian cycle. PMID:22220205

  2. Theme section for 36th International Symposium for Remote Sensing of the Environment in Berlin

    NASA Astrophysics Data System (ADS)

    Trinder, John; Waske, Björn

    2016-09-01

    The International Symposium for Remote Sensing of the Environment (ISRSE) is the longest series of international conferences held on the topic of Remote Sensing, commencing in Ann Arbor, Michigan USA in 1962. While the name of the conference has changed over the years, it is regularly held approximately every 2 years and continues to be one of the leading international conferences on remote sensing. The latest of these conferences, the 36th ISRSE, was held in Berlin, Germany from 11 to 15 May 2015. All complete papers from the conference are available in the ISPRS International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences at http://www.int-arch-photogramm-remote-sens-spatial-inf-sci.net/XL-7-W3/index.html.

  3. Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium.

    PubMed

    Smedsrød, Bård; Le Couteur, David; Ikejima, Kenichi; Jaeschke, Hartmut; Kawada, Norifumi; Naito, Makoto; Knolle, Percy; Nagy, Laura; Senoo, Haruki; Vidal-Vanaclocha, Fernando; Yamaguchi, Noriko

    2009-04-01

    This review aims to give an update of the field of the hepatic sinusoid, supported by references to presentations given at the 14th International Symposium on Cells of the Hepatic Sinusoid (ISCHS2008), which was held in Tromsø, Norway, August 31-September 4, 2008. The subtitle of the symposium, 'Integrating basic and clinical hepatology', signified the inclusion of both basal and applied clinical results of importance in the field of liver sinusoidal physiology and pathophysiology. Of nearly 50 oral presentations, nine were invited tutorial lectures. The authors of the review have avoided writing a 'flat summary' of the presentations given at ISCHS2008, and instead focused on important novel information. The tutorial presentations have served as a particularly important basis in the preparation of this update. In this review, we have also included references to recent literature that may not have been covered by the ISCHS2008 programme. The sections of this review reflect the scientific programme of the symposium (http://www.ub.uit.no/munin/bitstream/10037/1654/1/book.pdf): 1. Liver sinusoidal endothelial cells. 2. Kupffer cells. 3. Hepatic stellate cells. 4. Immunology. 5. Tumor/metastasis. Symposium abstracts are referred to by a number preceded by the letter A.

  4. Pulmonary serotonin and histamine in experimental asbestosis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Keith, I.M.; Day, R.; Lemaire, S.

    1986-03-01

    Adult male Wistar rats were treated once with tracheal instillation of 5 mg Crysotile B asbestos fibers in 0.5 ml saline under ketamine/xylaxine anesthesia. Control rats (n = 37) received 0.5 ml saline. Test and control rats were killed at 7 and 14 d., and 1, 3 and 6 mo. post instillation. Serotonin (5-HT) was quantitated in lung tissue homogenate from all rats using HPLC and electrochemical detection. Among rats killed at 1, 3 and 6 mo., lung tissue histamine-o-phthaldialdehyde complex was quantitated using reverse phase HPLC coupled to a fluorometric detector. Furthermore, 5-HT was quantitated in the cytoplasm ofmore » grouped (NEB) and individual (NEC) neuroendocrine cells and in mast cells using formaldehyde-vapor-induced fluorescence and microspectrofluorometry, and mast cell numbers were determined. Test rats had higher pulmonary 5-HT and histamine levels than controls at 1, 3 and 6 mo. Test rats also had higher cellular 5-HT compared to controls in NEB's at 1 mo., but not in NECs, and tended to have higher 5-HT-levels in mast cells at 6 mo. Mast cell numbers were higher among tests at 1 and 3 mo. The authors results suggest that NEBs may contribute to the early asbestos induced rise in 5-HT, and that the major source of 5-HT and histamine is from the increased numbers of mast cells.« less

  5. Room temperature synthesis and binding studies of solution-processable histamine-imprinted microspheres.

    PubMed

    Romano, Edwin F; Holdsworth, Clovia I; Quirino, Joselito P; So, Regina C

    2018-01-01

    Accurate quantification of histamine levels in food and in biological samples is important for monitoring the quality of food products and for the detection of pathophysiological conditions. In this study, solution processable histamine-imprinted microspheres were synthesized at 30°C via dilute free radical phototochemical polymerization technique using ethylene glycol dimethacrylate (EGDMA) as the crosslinker and methacrylic acid (MAA) as the monomer. The processability of the resulting polymer is dictated by the monomer feed concentration (eg, 4 wt% 80:20 EGDMA:MAA formulation) and solvent (acetonitrile). Whereas, the particle size is influenced by the monomer feed concentration, the presence of template molecule, and independent of the crosslinker content. Evaluation of the binding performance of the photochemically imprinted polymers (PCP) with different crosslinker content (80 and 90 wt%) indicated that the selective binding capacity was notably higher in PCP-80 (N= 16.0 μmol/g) compared to PCP-90 (N= 10.1 μmol/g) when analyzed via frontal analysis capillary electrophoresis (FACE) using Freundlich isotherm. In addition, PCP-80 microspheres are more selective toward histamine than conventional thermal polymers (CTP-80) prepared at 60°C in the presence of structural analogs such as histidine, imidazole, and tryptamine under cross-rebinding and competitive conditions. These results demonstrated that histamine-selective imprinted polymers can be obtained readily using room temperature photochemical polymerization where these materials can be subsequently used as recognition element for optical-based histamine sensing. Copyright © 2017 John Wiley & Sons, Ltd.

  6. Pharmacology of JB-9315, a new selective histamine H2-receptor antagonist.

    PubMed

    Palacios, B; Montero, M J; Sevilla, M A; San Román, L

    1998-02-01

    1. The histamine H2-receptor antagonistic activity and antisecretory and antiulcer effects of JB-9315 were studied in comparison with the standard H2 blocker ranitidine. 2. In vitro, JB-9315 is a competitive antagonist of histamine H2 receptors in the isolated, spontaneously beating guinea-pig right atrium, with a pA2 value of 7.30 relative to a value of 7.36 for ranitidine. JB-9315 was specific for the histamine H2 receptor because, at high concentration, it did not affect histamine- or acetylcholine-induced contractions in guinea-pig isolated ileum or rat isolated duodenum, respectively. 3. JB-9315 dose dependently inhibited histamine-, pentagastrin- or carbachol-stimulated acid secretion and basal secretion in the perfused stomach preparation of the anesthetized rat. In the pylorus-ligated rat after intraperitoneal administration, total acid output over 4 h was inhibited by JB-9315 with an ID50 of 32.8 mg/kg, confirming its H2-receptor antagonist properties. 4. JB-9315 showed antiulcer activity against cold stress plus indomethacin-induced lesions with an ID50 of 6.8 mg/kg. 5. JB-9315, 50 and 100 mg/kg, inhibited macroscopic gastric hemorrhagic lesions induced by ethanol. In contrast, ranitidine (50 mg/kg) failed to reduce these lesions. 6. These results indicate that JB-9315 is a new antiulcer drug that exerts a cytoprotective effect in addition to its gastric antisecretory activity.

  7. Pre-School Education--Aims, Methods and Problems. Report of a Symposium (Venice, Italy, October 11-16, 1971).

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France). Committee for General and Technical Education.

    This report provides a summary of the proceedings and recommendations of the Council of Europe symposium on preschool education held in Venice, Italy in 1971. The report is divided into three major areas: (1) historical background information; (2) summaries of general lectures, especially dealing with the functions, aims, methods, and problems of…

  8. Respiratory effects of cigarette smoke, dust, and histamine in newborn rabbits

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Trippenbach, T.; Kelly, G.

    1988-02-01

    We studied the respiratory effects of cigarette smoke, 5% histamine aerosol, and dust in unanesthetized 1- to 7-day-old rabbits in a body plethysmograph. Cigarette smoke immediately provoked the animal's arousal and irregular breathing. Histamine and dust had no effect in some of the youngest animals. In others, 5-15 s from the onset of the exposure to either of the two stimuli, respiratory rate increased and the depth of breathing decreased. These changes were more pronounced with age. The fact that effects of dust and aerosol lessened with time of exposure showed adaptation to the stimuli. The age dependence of themore » reflex response was also observed after injection of 50 micrograms of histamine per kilogram into the external jugular vein in anesthetized (50 mg ketamine + 3 mg acepromazine per kg) and tracheostomized rabbits during the 1st wk of life. In 1-day-old animals, a short-lasting excitation was followed by apnea or a prolongation of expiratory phase. Peak amplitude of the diaphragmatic EMG (EMGdi) increased in all animals, but only in the youngest was the EMGdi increase paralleled by an increase in tidal volume. In vagotomized animals or animals pretreated with H1-blocker, histamine never affected timing parameters in animals greater than 1 day old. In the youngest animals, respiratory depression due to histamine was not abolished after vagotomy or promethazine. The results imply that inputs from the upper airways and the rapidly adapting pulmonary mechanoreceptors exert their effects on the pattern of breathing immediately after birth in rabbits. The importance of those inputs increases with maturation.« less

  9. Structure-based discovery and binding site analysis of histamine receptor ligands.

    PubMed

    Kiss, Róbert; Keserű, György M

    2016-12-01

    The application of structure-based drug discovery in histamine receptor projects was previously hampered by the lack of experimental structures. The publication of the first X-ray structure of the histamine H1 receptor has been followed by several successful virtual screens and binding site analysis studies of H1-antihistamines. This structure together with several other recently solved aminergic G-protein coupled receptors (GPCRs) enabled the development of more realistic homology models for H2, H3 and H4 receptors. Areas covered: In this paper, the authors review the development of histamine receptor models and their application in drug discovery. Expert opinion: In the authors' opinion, the application of atomistic histamine receptor models has played a significant role in understanding key ligand-receptor interactions as well as in the discovery of novel chemical starting points. The recently solved H1 receptor structure is a major milestone in structure-based drug discovery; however, our analysis also demonstrates that for building H3 and H4 receptor homology models, other GPCRs may be more suitable as templates. For these receptors, the authors envisage that the development of higher quality homology models will significantly contribute to the discovery and optimization of novel H3 and H4 ligands.

  10. Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models

    PubMed Central

    Lamas, DJMartinel; Nicoud, MB; Sterle, HA; Carabajal, E; Tesan, F; Perazzo, JC; Cremaschi, GA; Rivera, ES; Medina, VA

    2015-01-01

    The aim of the present work was to evaluate the potential protective effect of histamine on Doxorubicin (Dox)-induced hepatic and cardiac toxicity in different rodent species and in a triple-negative breast tumor-bearing mice model. Male Sprague Dawley rats and Balb/c mice were divided into four groups: control (received saline), histamine (5 mg/kg for rats and 1 mg/kg for mice, daily subcutaneous injection starting 24 h before treatment with Dox), Dox (2 mg/kg, intraperitoneally injected three times a week for 2 weeks) and Dox+histamine (received both treatments). Tissue toxicity was evaluated by histopathological studies and oxidative stress and biochemical parameters. The combined effect of histamine and Dox was also investigated in vitro and in vivo in human MDA-MB-231 triple-negative breast cancer model. Heart and liver of Dox-treated animals displayed severe histological damage, loss of tissue weight, increased TBARS levels and DNA damage along with an augment in serum creatine kinase-myocardial band. Pretreatment with histamine prevented Dox-induced tissue events producing a significant preservation of the integrity of both rat and mouse myocardium and liver, through the reduction of Dox-induced oxidative stress and apoptosis. Histamine treatment preserved anti-tumor activity of Dox, exhibiting differential cytotoxicity and increasing the Dox-induced inhibition of breast tumor growth. Findings provide preclinical evidence indicating that histamine could be a promising candidate as a selective cytoprotective agent for the treatment of Dox-induced cardiac and hepatic toxicity, and encourage the translation to clinical practice. PMID:27551485

  11. A case of histamine fish poisoning in a young atopic woman.

    PubMed

    Wilson, Ben J; Musto, Richard J; Ghali, William A

    2012-07-01

    Histamine fish poisoning, also known as scombroid poisoning, is a histamine toxicity syndrome that results from eating specific types of spoiled fish. Although typically a benign syndrome, characterized by self-limited flushing, headache, and gastrointestinal symptoms, we describe a case unique in its severity and as a precipitant of an asthma exacerbation. A 25-year-old woman presented to the emergency department (ED) with one hour of tongue and face swelling, an erythematous pruritic rash, and dyspnea with wheezing after consuming a tuna sandwich. She developed abdominal pain, diarrhea and hypotension in the ED requiring admission to the hospital. A diagnosis of histamine fish poisoning was made and the patient was treated supportively and discharged within 24 hours, but was readmitted within 3 hours due to an asthma exacerbation. Her course was complicated by recurrent admissions for asthma exacerbations.

  12. Desipramine Inhibits Histamine H1 Receptor-Induced Ca2+ Signaling in Rat Hypothalamic Cells

    PubMed Central

    Lee, Kwang Min; Cho, Sukhee; Seo, Jinsoo; Hur, Eun-Mi; Park, Chul-Seung; Baik, Ja-Hyun; Choi, Se-Young

    2012-01-01

    The hypothalamus in the brain is the main center for appetite control and integrates signals from adipose tissue and the gastrointestinal tract. Antidepressants are known to modulate the activities of hypothalamic neurons and affect food intake, but the cellular and molecular mechanisms by which antidepressants modulate hypothalamic function remain unclear. Here we have investigated how hypothalamic neurons respond to treatment with antidepressants, including desipramine and sibutramine. In primary cultured rat hypothalamic cells, desipramine markedly suppressed the elevation of intracellular Ca2+ evoked by histamine H1 receptor activation. Desipramine also inhibited the histamine-induced Ca2+ increase and the expression of corticotrophin-releasing hormone in hypothalamic GT1-1 cells. The effect of desipramine was not affected by pretreatment with prazosin or propranolol, excluding catecholamine reuptake activity of desipramine as an underlying mechanism. Sibutramine which is also an antidepressant but decreases food intake, had little effect on the histamine-induced Ca2+ increase or AMP-activated protein kinase activity. Our results reveal that desipramine and sibutramine have different effects on histamine H1 receptor signaling in hypothalamic cells and suggest that distinct regulation of hypothalamic histamine signaling might underlie the differential regulation of food intake between antidepressants. PMID:22563449

  13. Symposium on Command and Control Research (1988) Held in Monterey, California on Jun 7-9, 1988

    DTIC Science & Technology

    1988-09-30

    four working groups , each one of which provided a tracl, throughout the three days The program included five plenary sessions, four of them featured...at the Symposium, to be followed by the Proceedings soon after. Finally, we would like to thank the four working group chairmen, Dick Wishner, John...accreditation. Management of changes authorized respectively. Group 2 of the Summer Study dealt for hunan-arcessible systen. is complicated but with

  14. 77 FR 16048 - U.S. Customs and Border Protection 2012 West Coast Trade Symposium: “Harmonizing Trade for a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-19

    ...This year, U.S. Customs and Border Protection (CBP) will be holding two trade symposia. One trade symposium will be held on the West Coast in May and the other will be on the East Coast later in the year. This document announces that CBP will convene the 2012 West Coast Trade Symposium to discuss issues relating to the agency's role in international trade initiatives and programs. This year marks our twelfth year hosting trade symposia. Members of the international trade and transportation communities and other interested parties on the West Coast are encouraged to attend.

  15. Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors‘ Behavioral and Neurochemical Effects

    PubMed Central

    Munari, Leonardo; Provensi, Gustavo; Passani, Maria Beatrice; Galeotti, Nicoletta; Cassano, Tommaso; Benetti, Fernando; Corradetti, Renato

    2015-01-01

    Backgound: The neurobiological changes underlying depression resistant to treatments remain poorly understood, and failure to respond to selective serotonin reuptake inhibitors may result from abnormalities of neurotransmitter systems that excite serotonergic neurons, such as histamine. Methods: Using behavioral (tail suspension test) and neurochemical (in vivo microdialysis, Western-blot analysis) approaches, here we report that antidepressant responses to selective serotonin reuptake inhibitors (citalopram or paroxetine) are abolished in mice unable to synthesize histamine due to either targeted disruption of histidine decarboxylase gene (HDC-/-) or injection of alpha-fluoromethylhistidine, a suicide inhibitor of this enzyme. Results: In the tail suspension test, all classes of antidepressants tested reduced the immobility time of controls. Systemic reboxetine or imipramine reduced the immobility time of histamine-deprived mice as well, whereas selective serotonin reuptake inhibitors did not even though their serotonergic system is functional. In in vivo microdialysis experiments, citalopram significantly increased histamine extraneuronal levels in the cortex of freely moving mice, and methysergide, a serotonin 5-HT1/5-HT2 receptor antagonist, abolished this effect, thus suggesting the involvement of endogenous serotonin. CREB phosphorylation, which is implicated in the molecular mechanisms of antidepressant treatment, was abolished in histamine-deficient mice treated with citalopram. The CREB pathway is not impaired in HDC-/- mice, as administration of 8-bromoadenosine 3’, 5’-cyclic monophosphate increased CREB phosphorylation, and in the tail suspension test it significantly reduced the time spent immobile by mice of both genotypes. Conclusions: Our results demonstrate that selective serotonin reuptake inhibitors selectively require the integrity of the brain histamine system to exert their preclinical responses. PMID:25899065

  16. Summaries of the Regional Conferences Held in Preparation for the Second International Congress on Technical and Vocational Education.

    ERIC Educational Resources Information Center

    UNEVOC Info, 1999

    1999-01-01

    In 1998, five regional conferences were held in preparation for the Second International Congress on Technical and Vocational Education (TVE). The Asia-Pacific regional conference focused on challenges of the 21st century, demands of the world of work, and changing patterns in the delivery of training programs. The European symposium covered five…

  17. Sleep medicine is coming of age in military medicine : Report from the Military Health System Research Symposium (2017) in Kissimmee, Florida.

    PubMed

    Eliasson, Arn H; Lettieri, Christopher; Netzer, Nikolaus

    2018-05-01

    In August 2017, the US Military Health System held its sixth annual Research Symposium for medical researchers from the US Army, Navy, Air Force, and Public Health Service. The symposium provides a collaborative environment for academia, industry, and military researchers who address advancement in areas of Combat Casualty Care, Military Operational Medicine, Clinical and Rehabilitative Medicine, and Military Infectious Diseases. This year, Sleep Medicine received substantial attention with presentations scattered throughout the program, poster presentations as well as a scheduled breakout session with podium presentations. A brief description of the breakout session follows.

  18. The current status of immunotoxins: an overview of experimental and clinical studies as presented at the Third International Symposium on Immunotoxins.

    PubMed

    Uckun, F M; Frankel, A

    1993-02-01

    The Third International Symposium on Immunotoxins was held on June 19-21, 1992 in Orlando, Florida. This symposium was sponsored by NATO, NIH, Pierce Chemical Company, Walt Disney Cancer Institute at Florida Hospital, Duke Comprehensive Cancer Center, Xoma, Immunogen, Seragen, Bristol-Myers Squibb, Chiron, Ortho Biotech, Upjohn, Merck Sharp & Dohme Research Laboratories, Abbot Laboratories, Lilly Research Laboratories, and Evans & Sutherland. The Pierce Immunotoxin Award which recognizes outstanding contributions to immunotoxin research and development, was presented to Drs David FitzGerald, Fatih Uckun, David Eisenberg, and Ira Wool, for their contributions to the immunotoxin field.

  19. In vitro histamine H/sub 2/-antagonist activity of the novel compound HUK 978

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Coombes, J.D.; Norris, D.B.; Rising, T.J.

    1985-11-04

    Histamine stimulated adenylate cyclase from guinea-pig fundic mucosa and /sup 3/H-tiotidine binding in guinea-pig cerebral cortex were used to assess the in-vitro histamine H/sub 2/-activity of the novel H/sub 2/-antagonist HUK 978. The results showed that HUK 978 was a more potent H/sub 2/-antagonist than either cimetidine or ranitidine. HUK 978 was also shown to be devoid of activity at the histamine H-/sub 1/-receptor, the muscarinic receptor and the ..cap alpha.. and ..beta..-adrenergic receptors.

  20. Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-κB Pathways in Nasal Fibroblasts.

    PubMed

    Park, Il-Ho; Um, Ji-Young; Cho, Jung-Sun; Lee, Seung Hoon; Lee, Sang Hag; Lee, Heung-Man

    2014-11-01

    Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. Here, we examined the role of histamine in IL-6 production and histamine receptor activity in nasal fibroblasts, along with the mechanisms underlying these effects. Experiments were performed using nasal fibroblasts from 8 normal patients. RT-PCR was used to identify the major histamine receptors expressed in nasal fibroblasts. Fibroblasts were then treated with histamine with or without histamine-receptor antagonists, and monitored for IL-6 production using an ELISA. Four potential downstream signaling molecules, p38, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and NF-κB, were evaluated by Western blot, and a luciferase reporter assay. Elevated expression was seen for all histamine receptors, with IL-6 protein levels increasing significantly following histamine stimulation. Among the histamine-receptor specific antagonists, only the H1R antagonist significantly decreased IL-6 production in histamine-stimulated nasal fibroblasts. Histamine increased the expression level of phosphorylated p38 (pp38), pERK, and pJNK, as well as NF-κB induction. The H1R antagonist actively suppressed pp38 and NF-κB expression in histamine-induced nasal fibroblasts, but not pERK and pJNK. The p38 inhibitor strongly attenuated IL-6 production in histamine-stimulated nasal fibroblasts. The data presented here suggest that antihistamines may be involved in the regulation of cytokines, such as IL-6, due to the role of histamine as an inflammatory mediator in nasal fibroblasts.

  1. Protective effect of histamine microinjected into cerebellar fastigial nucleus on stress gastric mucosal damage in rats.

    PubMed

    Qiao, Xiao; Yang, Jun; Fei, Su-Juan; Zhu, Jin-Zhou; Zhu, Sheng-Ping; Liu, Zhang-Bo; Li, Ting-Ting; Zhang, Jian-Fu

    2015-12-10

    In the study, we investigated the effect of histamine microinjected into cerebellar fastigial nucleus (FN) on stress gastric mucosal damage (SGMD), and its mechanisms in rats. The model of SGMD was established by restraining and water (21±1°C)-immersion for 3h. The gastric mucosal damage index (GMDI) indicated the severity of gastric mucosal damage. Histamine or receptor antagonist was microinjected into the FN. The decussation of superior cerebellar peduncle (DSCP) and the lateral hypothalamic area (LHA) were destroyed, respectively. The pathological changes of gastric mucosa were evaluated using biological signal acquisition system, Laser-Doppler flowmeter, and western blotting. We found that the microinjection of histamine (0.05, 0.5, and 5μg) into FN significantly attenuated the SGMD, in a dose-dependent manner, whereas, the microinjection of histamine H2 receptor antagonist, ranitidine, and glutamic acid decarboxylase antagonist, 3-mercaptopropionic acid (3-MPA) exacerbated the SGMD. The protective effect of histamine on SGMD was abolished by electrical lesion of DSCP or chemical ablation of LHA. The microinjection of histamine decreased the discharge frequency of the greater splanchnic nerve, and the gastric mucosal blood flow was increased. In addition, the cellular proliferation was enhanced, but the cellular apoptosis was reduced in the gastric mucosa. Also the pro-apoptosis protein, Bax, and caspase-3 were down-regulated, and the anti-apoptosis protein, Bcl-2 was up-regulated following microinjection of histamine. In conclusion, the FN participated in the regulation of SGMD after histamine microinjected into FN, and cerebellar-hypothalamic circuits (include: DSCP, LHA) contribute to the process, which may provide a new therapeutic strategy for SGMD. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Asia Federation Report on International Symposium on Grid Computing (ISGC) 2010

    NASA Astrophysics Data System (ADS)

    Grey, Francois; Lin, Simon C.

    This report provides an overview of developments in the Asia-Pacific region, based on presentations made at the International Symposium on Grid Computing 2010 (ISGC 2010), held 5-12 March at Academia Sinica, Taipei. The document includes a brief overview of the EUAsiaGrid project as well as progress reports by representatives of 13 Asian countries presented at ISGC 2010. In alphabetical order, these are: Australia, China, India, Indonesia, Japan, Malaysia, Pakistan, Philippines, Singapore, South Korea, Taiwan, Thailand and Vietnam.

  3. Induction of histamine release in vitro from rat peritoneal mast cells by extracts of grain dust.

    PubMed Central

    Warren, C P; Holford-Strevens, V

    1986-01-01

    The ability of extracts of grain dust and wheat to induce histamine release from rat peritoneal cells was investigated. Some grain dusts, with a high endotoxin content, were found to produce cytotoxic histamine release. Extract of wheat dust, with a low endotoxin release, produced noncytotoxic histamine release from peritoneal cells but not from purified mast cells. This reaction was dependent on the presence of phosphatidyl serine. The agent did not appear to be a lectin because histamine release was not enhanced by passive sensitization of mast cells with IgE. The activity occurred only over a narrow range of concentrations of the extract of wheat. The cause was unclear. PMID:2423321

  4. Don't be rejected, how can we help authors, reviewers and editors?: Report of a Symposium for Editors Publishers and Others with an Interest in Scientific Publication, Held in Boston on Wednesday, 11 March 2015, during the Annual Meeting of the International Association for Dental Research.

    PubMed

    Eaton, K A; Innes, N; Balaji, S M; Pugh, C; Honkala, E; Lynch, C D

    2017-02-01

    This satellite symposium was the fifth in a series for editors, publishers, reviewers and all those with an interest in scientific publishing. It was held on Wednesday, 11 March 2015 at the IADR meeting in Boston, Massachusetts. The symposium attracted more than 210 attendees. The symposium placed an emphasis on strategies to ensure that papers are accepted by peer reviewed journals. The speaker, representing the Journal of Dental Research gave a history of peer review and explained how to access material to advise new authors. The speaker from India outlined the problems that occur when there is no culture for dental research and it is given a low priority in dental education. He outlined remedies. The speaker from SAGE publications described the help that publishers and editors can provide authors. The final speaker suggested that in developing countries it was essential to create alliances with dental researchers in developed countries and that local conferences to which external speakers were invited, stimulated research both in terms of quantity and quality. A wide ranging discussion then took place. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. PREFACE: XXXV Symposium on Nuclear Physics

    NASA Astrophysics Data System (ADS)

    Padilla-Rodal, E.; Bijker, R.

    2012-09-01

    Conference logo The XXXV Symposium on Nuclear Physics was held at Hotel Hacienda Cocoyoc, Morelos, Mexico from January 3-6 2012. Conceived in 1978 as a small meeting, over the years and thanks to the efforts of various organizing committees, the symposium has become a well known international conference on nuclear physics. To the best of our knowledge, the Mexican Symposium on Nuclear Physics represents the conference series with longest tradition in Latin America and one of the longest-running annual nuclear physics conferences in the world. The Symposium brings together leading scientists from all around the world, working in the fields of nuclear structure, nuclear reactions, physics with radioactive ion beams, hadronic physics, nuclear astrophysics, neutron physics and relativistic heavy-ion physics. Its main goal is to provide a relaxed environment where the exchange of ideas, discussion of new results and consolidation of scientific collaboration are encouraged. To celebrate the 35th edition of the symposium 53 colleagues attended from diverse countries including: Argentina, Australia, Canada, Japan, Saudi Arabia and USA. We were happy to have the active participation of Eli F Aguilera, Eduardo Andrade, Octavio Castaños, Alfonso Mondragón, Stuart Pittel and Andrés Sandoval who also participated in the first edition of the Symposium back in 1978. We were joined by old friends of Cocoyoc (Stuart Pittel, Osvaldo Civitarese, Piet Van Isacker, Jerry Draayer and Alfredo Galindo-Uribarri) as well as several first time visitors that we hope will come back to this scientific meeting in the forthcoming years. The scientific program consisted of 33 invited talks, proposed by the international advisory committee, which nicely covered the topics of the Symposium giving a balanced perspective between the experimental and the theoretical work that is currently underway in each line of research. Fifteen posters complemented the scientific sessions giving the opportunity

  6. Proceedings of the Fourth Social Aspects and Recreation Research Symposium: February 4-6, 2004, San Francisco, California

    Treesearch

    Patrick T. Tierney; Deborah J. (Tech. coords.) Chavez

    2004-01-01

    The Fourth Social Aspects and Recreation Research (SARR) Symposium was held February 4-6, 2004 in San Francisco, California at the Presidio of San Francisco, a component of Golden Gate National Recreation Area and at San Francisco State University. The theme was: Linking People to the Outdoors: Connections for Healthy Lands, People and Communities.

  7. The effect of vacuum packaging on histamine changes of milkfish sticks at various storage temperatures.

    PubMed

    Kung, Hsien-Feng; Lee, Yi-Chen; Lin, Chiang-Wei; Huang, Yu-Ru; Cheng, Chao-An; Lin, Chia-Min; Tsai, Yung-Hsiang

    2017-10-01

    The effects of polyethylene packaging (PEP) (in air) and vacuum packaging (VP) on the histamine related quality of milkfish sticks stored at different temperatures (-20°C, 4°C, 15°C, and 25°C) were studied. The results showed that the aerobic plate count (APC), pH, total volatile basic nitrogen (TVBN), and histamine contents increased as storage time increased when the PEP and VP samples were stored at 25°C. At below 15°C, the APC, TVBN, pH, and histamine levels in PEP and VP samples were retarded, but the VP samples had considerably lower levels of APC, TVBN, and histamine than PEP samples. Once the frozen fish samples stored at -20°C for 2 months were thawed and stored at 25°C, VP retarded the increase of histamine in milkfish sticks as compared to PEP. In summary, this result suggested the milkfish sticks packed with VP and stored below 4°C could prevent deterioration of product quality and extend shelf-life. Copyright © 2017. Published by Elsevier B.V.

  8. Excitation of mouse superficial dorsal horn neurons by histamine and/or PAR-2 agonist: potential role in itch.

    PubMed

    Akiyama, Tasuku; Carstens, Mirela Iodi; Carstens, E

    2009-10-01

    Recent studies have suggested the existence of separate transduction mechanisms and sensory pathways for histamine and nonhistaminergic types of itch. We studied whether histamine and an agonist of the protease-activated receptor (PAR)-2, associated with nonhistaminergic itch, excite murine dorsal horn neurons. Single units were recorded in superficial lumbar dorsal horn of adult ICR mice anesthetized with pentobarbital. Unit activity was searched using a small intradermal hindpaw injection of histamine or the PAR-2 agonist SLIGRL-NH2. Isolated units were subsequently challenged with intradermal histamine followed by SLIGRL-NH2 (each 50 microg/1 microl) or reverse order, followed by mechanical, thermal, and algogenic stimuli. Forty-three units were classified as wide dynamic range (62%), nociceptive specific (22%), or mechano insensitive (16%). Twenty units gave prolonged (mean, 10 min) discharges to intradermal injection of histamine; 76% responded to subsequent SLIGRL-NH2, often more briefly. Units additionally responded to noxious heat (63%), cooling (43%), topical mustard oil (53%), and intradermal capsaicin (67%). Twenty-two other units gave prolonged (mean, 5 min) responses to initial intradermal injection of SLIGRL-NH2; 85% responded to subsequent intradermal histamine. They also responded to noxious heat (75%), mustard oil (93%), capsaicin (63%), and one to cooling. Most superficial dorsal horn neurons were excited by both histamine and the PAR-2 agonist, suggesting overlapping pathways for histamine- and non-histamine-mediated itch. Because the large majority of pruritogen-responsive neurons also responded to noxious stimuli, itch may be signaled at least partly by a population code.

  9. Histamine and Tyramine in Food.

    DTIC Science & Technology

    1985-05-01

    normal constituents of many foods and have been found in cheese; sauerkraut; wine; fish; and putrid, aged or fermented meats. These low molecular...constituents of many foods and have been found in cheese; sauerkraut; wine; fish; and putrid, aged, or fermented meats. These low molecular weight organic...amounts of tyramine and histamine, formation of large amounts of these amines has been reported only in aged, fermented products or products such as

  10. FAA/NASA En Route Noise Symposium

    NASA Technical Reports Server (NTRS)

    Powell, Clemans A. (Compiler)

    1990-01-01

    Aircraft community noise annoyance is traditionally a concern only in localities near airports. The proposed introduction of large commercial airplanes with advanced turboprop propulsion systems with supersonic propellers has given rise to concerns of noise annoyance in areas previously considered not to be impacted by aircraft noise. A symposium was held to assess the current knowledge of factors important to the impact of en route noise and to aid in the formulation of FAA and NASA programs in the area. Papers were invited on human response to aircraft noise in areas with low ambient noise levels, aircraft noise heard indoors and outdoors, aircraft noise in recreational areas, detection of propeller and jet aircraft noise, and methodological issues relevant to the design of future studies.

  11. Generation of a proton motive force by histidine decarboxylation and electrogenic histidine/histamine antiport in Lactobacillus buchneri.

    PubMed

    Molenaar, D; Bosscher, J S; ten Brink, B; Driessen, A J; Konings, W N

    1993-05-01

    Lactobacillus buchneri ST2A vigorously decarboxylates histidine to the biogenic amine histamine, which is excreted into the medium. Cells grown in the presence of histidine generate both a transmembrane pH gradient, inside alkaline, and an electrical potential (delta psi), inside negative, upon addition of histidine. Studies of the mechanism of histidine uptake and histamine excretion in membrane vesicles and proteoliposomes devoid of cytosolic histidine decarboxylase activity demonstrate that histidine uptake, histamine efflux, and histidine/histamine exchange are electrogenic processes. Histidine/histamine exchange is much faster than the unidirectional fluxes of these substrates, is inhibited by an inside-negative delta psi and is stimulated by an inside positive delta psi. These data suggest that the generation of metabolic energy from histidine decarboxylation results from an electrogenic histidine/histamine exchange and indirect proton extrusion due to the combined action of the decarboxylase and carrier-mediated exchange. The abundance of amino acid decarboxylation reactions among bacteria suggests that this mechanism of metabolic energy generation and/or pH regulation is widespread.

  12. Rare Death Via Histamine Poisoning Following Crab Consumption: A Case Report.

    PubMed

    Yu, Yang; Wang, Ping; Bian, Ligong; Hong, Shijun

    2018-05-01

    Histamine poisoning (scombroid food poisoning) is a toxicity syndrome that results from eating spoiled fish. To date, however, few poisoning (or mortality) cases have been reported in relation to crab consumption. Here, we describe a very uncommon case in which a 37-year-old woman and her 14-year-old son ate cooked crabs (Scylla serrata), resulting in the death of the female. Samples of vomitus, food residue, liver tissue, gastric content, intestinal content, and cardiac blood were analyzed by high-performance liquid chromatography. Toxicological analysis revealed that histamine concentrations were very high in the cooked crab (47.08 mg/100 g) and intestinal content (22.54 mg/100 g). Comparing our toxicological results, police investigations, and family member statements, it can be assumed that the decedent ingested spoiled crabs, and by excluding other causes of death, lethal intoxication with histamine poisoning was confirmed. © 2017 American Academy of Forensic Sciences.

  13. International Symposium on Coastal Lagoons. (Bordeaux, France, September 8-14, 1981). Unesco Technical Papers in Marine Science 43.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). Div. of Marine Sciences.

    Lagoons and their characteristic coastal bay-mouth bars represent 15 percent of the world coastal zone. They are among the most productive ecosystems in the biosphere, this productivity resulting from the interplay of ocean and continent. An International Symposium on Coastal Lagoons (ISCOL) was held to: assess the state of knowledge in the…

  14. Report from the Third Annual Symposium of the RIKEN-Max Planck Joint Research Center for Systems Chemical Biology.

    PubMed

    Brunschweiger, Andreas

    2014-08-15

    The third Annual Symposium of the RIKEN-Max Planck Joint Research Center for Systems Chemical Biology was held at Ringberg castle, May 21-24, 2014. At this meeting 45 scientists from Japan and Germany presented the latest results from their research spanning a broad range of topics in chemical biology and glycobiology.

  15. Proceedings of the 2016 Santa Fe Bone Symposium: New Concepts in the Management of Osteoporosis and Metabolic Bone Diseases.

    PubMed

    Lewiecki, E Michael; Bilezikian, John P; Bukata, Susan V; Camacho, Pauline; Clarke, Bart L; McClung, Michael R; Miller, Paul D; Shepherd, John

    The Santa Fe Bone Symposium is an annual meeting of healthcare professionals and clinical researchers that details the clinical relevance of advances in knowledge of skeletal diseases. The 17th Santa Fe Bone Symposium was held in Santa Fe, New Mexico, USA, on August 5-6, 2016. The program included plenary lectures, oral presentations by endocrinology fellows, meet-the-professor sessions, and panel discussions, all aimed to provide ample opportunity for interactive discussions among all participants. Symposium topics included recent developments in the translation of basic bone science to patient care, new clinical practice guidelines for postmenopausal osteoporosis, management of patients with disorders of phosphate metabolism, new and emerging treatments for rare bone diseases, strategies to enhance fracture healing, and an update on Bone Health Extension for Community Healthcare Outcomes, using a teleconferencing platform to elevate the level of knowledge of healthcare professionals in underserved communities to deliver best practice care for skeletal diseases. The highlights and important clinical messages of the 2016 Santa Fe Bone Symposium are provided herein by each of the faculty presenters. Copyright © 2017. Published by Elsevier Inc.

  16. PREFACE: International Symposium on Geohazards and Geomechanics (ISGG2015)

    NASA Astrophysics Data System (ADS)

    Utili, S.

    2015-09-01

    These Conference Proceedings contain the full papers in electronic format of the International Symposium on 'Geohazards and Geomechanics', held at University of Warwick, UK, on September 10-11, 2015. The Symposium brings together the complementary expertise of world leading groups carrying out research on the engineering assessment, prevention and mitigation of geohazards. A total of 58 papers, including 8 keynote lectures cover phenomena such as landslide initiation and propagation, debris flow, rockfalls, soil liquefaction, ground improvement, hazard zonation, risk mapping, floods and gas and leachates. The techniques reported in the papers to investigate geohazards involve numerical modeling (finite element method, discrete element method, material point method, meshless methods and particle methods), experimentation (laboratory experiments, centrifuge tests and field monitoring) and analytical simplified techniques. All the contributions in this volume have been peered reviewed according to rigorous international standards. However the authors take full responsibility for the content of their papers. Agreements are in place for the edition of a special issue dedicated to the Symposium in three international journals: Engineering Geology, Computational Particle Mechanics and International Journal of Geohazards and Environment. Authors of selected papers will be invited to submit an extended version of their work to these Journals that will independently assess the papers. The Symposium is supported by the Technical Committee 'Geo-mechanics from Micro to Macro' (TC105) of the International Society for Soil Mechanics and Geotechnical Engineering (ISSMGE), 'Slope Stability in Engineering Practice' (TC208), 'Forensic Geotechnical Engineering' (TC302), the British Geotechnical Association and the EU FP7 IRSES project 'Geohazards and Geomechanics'. Also the organizers would like to thank all authors and their supporting institutions for their contributions. For any

  17. Space Transportation Propulsion Technology Symposium. Volume 1: Executive summary

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Space Transportation Propulsion Technology Symposium was held to provide a forum for communication within the propulsion within the propulsion technology developer and user communities. Emphasis was placed on propulsion requirements and initiatives to support current, next generation, and future space transportation systems, with the primary objectives of discerning whether proposed designs truly meet future transportation needs and identifying possible technology gaps, overlaps, and other programmatic deficiencies. Key space transportation propulsion issues were addressed through four panels with government, industry, and academia membership. The panels focused on systems engineering and integration; development, manufacturing and certification; operational efficiency; and program development and cultural issues.

  18. The New Engineering Research Centers: Purposes, Goals, and Expectations. Symposium (District of Columbia, April 29-30, 1985).

    ERIC Educational Resources Information Center

    National Academy of Sciences - National Research Council, Washington, DC. Commission on Engineering and Technical Systems.

    The sympoisum was held to describe the roots and future plans of the Engineering Research Center's (ERC's) concept and program. The first section of this symposium compilation describes the national goals that the ERCs represent. The second section presents the point of view of the National Science Foundation on the ERCs--the concept behind them,…

  19. The Second Annual Symposium of the NASA Specialized Center of Research and Training (NSCORT) in Gravitational Biology.

    PubMed

    Spooner, B S

    1993-04-01

    The second annual meeting of the NSCORT in Gravitational Biology was held at Kansas State University on September 29-October 1, 1992. Symposium presentations at the meeting included ones on basic gravitational cellular and developmental biology, spaceflight hardware for biological studies, studies on Space Shuttle, and special talks on Space Station Freedom and on life support systems.

  20. The Second Annual Symposium of the NASA Specialized Center of Research and Training (NSCORT) in Gravitational Biology

    NASA Technical Reports Server (NTRS)

    Spooner, B. S.

    1993-01-01

    The second annual meeting of the NSCORT in Gravitational Biology was held at Kansas State University on September 29-October 1, 1992. Symposium presentations at the meeting included ones on basic gravitational cellular and developmental biology, spaceflight hardware for biological studies, studies on Space Shuttle, and special talks on Space Station Freedom and on life support systems.

  1. Black Ducks and Their Chesapeake Bay Habitats: Proceedings of a Symposium

    USGS Publications Warehouse

    Perry, Matthew C.

    2002-01-01

    The symposium 'Black Ducks and Their Chesapeake Bay Habitats,' held October 4,2000, provided a forum for scientists to share research about the American black duck (Anas rubripes), an important breeding and wintering waterfowl species dependent upon the Chesapeake Bay habitats. American black ducks have declined significantly in the last 50 years and continue to be a species of management concern. The symposium, sponsored by the Wildfowl Trust of North America and the U.S. Geological Survey, highlighted papers and posters on a range of topics, from the traditional concerns of hunting, habitat, and hybridization to the more recent concerns of human disturbance and neophobia. Other presentations provided a historical perspective of black duck management. The direction that black duck conservation initiatives could and/or should take in the future was also discussed. As populations of humans in the Chesapeake Bay region continue to increase, we can expect that these subjects will receive increased discussion in the future.

  2. Proceedings of the twelfth international symposium on remote sensing of environment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This is the third of three volumes of the proceedings of the Twelfth International Symposium on Remote Sensing of Environment, held 20 to 26 April 1978 in Manila, Philippines. This symposium is part of a continuing program investigating current activities in the field of remote sensing. The meeting is intended to promote increased international cooperation in research, development and application of this technology, and to stimulate an exchange of information on all aspects of this multidisciplinary field through the presentation of reports on work planned, in progress or completed. Presentations include those concerned with the utilization of this technology inmore » various national and international programs as well as in numerous applications for monitoring and managing the earth's resources and man's global environment. Ground-based, airborne, and spaceborne sensor systems and both manual and machine-assisted data analysis and interpretation are included. All papers included in their entirety were abstracted and indexed for EDB/ERA.« less

  3. Inhibitory effects of carbohydrates on histamine release and mast cell disruption by dextran

    PubMed Central

    Beraldo, W. T.; Da Silva, W. dias; Fernandes, A. D. Lemos

    1962-01-01

    Alloxan diabetic rats failed to show the skin reaction (blue spot) evoked by dextran, whereas the effects produced by histamine and compound 48/80 were not altered. When dextran and glucose were injected simultaneously into the skin the reaction was inhibited. In vitro, mast cell alterations produced by dextran occurred simultaneously with histamine release; both processes were inhibited by glucose, other carbohydrates related to glucose, and inhibitors of anaphylaxis. These experiments suggest that dextran releases histamine by a mechanism similar to that found with 48/80 and anaphylaxis in the rat. The inhibitory effect of carbohydrates may be understood on the basis of a competitive mechanism. ImagesFig. 1Fig. 2 PMID:13967594

  4. Brain Death and Human Organismal Integration: A Symposium on the Definition of Death.

    PubMed

    Moschella, Melissa

    2016-06-01

    Does the ability of some brain dead bodies to maintain homeostasis with the help of artificial life support actually imply that those bodies are living human organisms? Or might it be possible that a brain dead body on life support is a mere collection of still-living cells, organs and tissues which can coordinate with one another, but which lack the genuine integration that is the hallmark of a unified human organism as a whole? To foster further study of these difficult and timely questions, a Symposium on the Definition of Death was held at The Catholic University of America in June 2014. The Symposium brought together scholars from a variety of disciplines-law, medicine, biology, philosophy and theology-who all share a commitment to the dead donor rule and to a biological definition of death, but who have differing opinions regarding the validity of neurological criteria for human death. The papers found in this special issue are among the fruits of this Symposium. © The Author 2016. Published by Oxford University Press, on behalf of the Journal of Medicine and Philosophy Inc. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  5. The 2nd Annual Clinical Scientist Trainee Symposium, August 22, 2017, London, Canada.

    PubMed

    Yin, Charles; Blom, Jessica N; Lewis, James F

    2018-03-27

    Clinician scientists play a critical role in bridging research and clinical practice. Unfortunately, the neglect of research training in medical schools has created clinicians who are unable to translate evidence from literature to practice. Furthermore, the erosion of research training in medical education has resulted in clinicians who lack the skills required for successful scientific investigation. To counteract this, the Schulich School of Medicine & Dentistry has made an effort to engage trainees, at all levels, in the research process. The 2nd Annual Clinician Scientist Trainee Symposium was held in London, Ontario, Canada on August 22, 2017. Organized each year since 2016 by the Schulich Research Office, the symposium features research being conducted by trainees in Schulich's Clinical Research Training Program. The focus this year was on the current state of clinician-scientist training in Canada and visions for the path ahead.

  6. Proceedings of the 40th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Littlefield, Alan C.; Mueller, Robert P.; Boesiger, Edward A. (Editor)

    2010-01-01

    The Aerospace Mechanisms Symposium (AMS) provides a unique forum for those active in the design, production and use of aerospace mechanisms. A major focus is the reporting of problems and solutions associated with the development and flight certification of new mechanisms. Organized by the Mechanisms Education Association, responsibility for hosting the AMS is shared by the National Aeronautics and Space Administration and Lockheed Martin Space Systems Company (LMSSC). Now in its 40th symposium, the AMS continues to be well attended, attracting participants from both the U.S. and abroad. The 40th AMS, hosted by the Kennedy Space Center (KSC) in Cocoa Beach, Florida, was held May 12, 13 and 14, 2010. During these three days, 38 papers were presented. Topics included gimbals and positioning mechanisms, CubeSats, actuators, Mars rovers, and Space Station mechanisms. Hardware displays during the supplier exhibit gave attendees an opportunity to meet with developers of current and future mechanism components. The use of trade names of manufacturers in this publication does not constitute an official endorsement of such products or manufacturers, either expressed or implied, by the National Aeronautics and Space Administration

  7. The second International Symposium on Fungal Stress: ISFUS.

    PubMed

    Alder-Rangel, Alene; Bailão, Alexandre M; da Cunha, Anderson F; Soares, Célia M A; Wang, Chengshu; Bonatto, Diego; Dadachova, Ekaterina; Hakalehto, Elias; Eleutherio, Elis C A; Fernandes, Éverton K K; Gadd, Geoffrey M; Braus, Gerhard H; Braga, Gilberto U L; Goldman, Gustavo H; Malavazi, Iran; Hallsworth, John E; Takemoto, Jon Y; Fuller, Kevin K; Selbmann, Laura; Corrochano, Luis M; von Zeska Kress, Marcia R; Bertolini, Maria Célia; Schmoll, Monika; Pedrini, Nicolás; Loera, Octavio; Finlay, Roger D; Peralta, Rosane M; Rangel, Drauzio E N

    2018-06-01

    The topic of 'fungal stress' is central to many important disciplines, including medical mycology, chronobiology, plant and insect pathology, industrial microbiology, material sciences, and astrobiology. The International Symposium on Fungal Stress (ISFUS) brought together researchers, who study fungal stress in a variety of fields. The second ISFUS was held in May 8-11 2017 in Goiania, Goiás, Brazil and hosted by the Instituto de Patologia Tropical e Saúde Pública at the Universidade Federal de Goiás. It was supported by grants from CAPES and FAPEG. Twenty-seven speakers from 15 countries presented their research related to fungal stress biology. The Symposium was divided into seven topics: 1. Fungal biology in extreme environments; 2. Stress mechanisms and responses in fungi: molecular biology, biochemistry, biophysics, and cellular biology; 3. Fungal photobiology in the context of stress; 4. Role of stress in fungal pathogenesis; 5. Fungal stress and bioremediation; 6. Fungal stress in agriculture and forestry; and 7. Fungal stress in industrial applications. This article provides an overview of the science presented and discussed at ISFUS-2017. Copyright © 2017 British Mycological Society. Published by Elsevier Ltd. All rights reserved.

  8. Letter from Seoul: Correspondence from the International Arts Education Symposium and the Asia-Pacific Regional Conference

    ERIC Educational Resources Information Center

    Aprill, Arnold; Schroeder-Yu, Gigi

    2006-01-01

    Arts educator Gigi Schroeder-Yu and Arnold Aprill arrived in Seoul, Korea to participate in the International Arts Education Symposium and in the Asia-Pacific Regional Conference that are part of the wind up for the pitch of the UNESCO World Conference on Arts Education to be held in Lisbon in March 2006. In this article, they reflect on their…

  9. Tyramine and histamine risk assessment related to consumption of dry fermented sausages by the Spanish population.

    PubMed

    Latorre-Moratalla, M L; Comas-Basté, O; Bover-Cid, S; Vidal-Carou, M C

    2017-01-01

    Tyramine and histamine are the main dietary bioactive amines related to acute adverse health effects. Dry fermented sausages can easily accumulate high levels of these hazards and are frequently consumed in Spain. The present work aims to assess the exposure to tyramine and histamine from the consumption of dry fermented sausages by the Spanish population and to assess the risk to suffer acute health effects from this exposure. A probabilistic estimation of the exposure to these hazards was derived combining probability distributions of these amines in dry fermented sausages (n = 474) and their consumption by the Spanish population. The mean dietary exposure to tyramine and histamine was 6.2 and 1.39 mg/meal, respectively. The risk of suffering hypertensive crisis or histamine intoxication by healthy population due to tyramine or histamine intake, respectively, exclusively from dry fermented sausages, can be considered negligible. For individuals under treatment with MAOI drugs, the probability to surpass the safe threshold dose (6 mg/meal) was estimated as 34%. For patients with histamine intolerance, even the presence of this amine in food is not tolerable and it could be estimated that 7000 individuals per million could be at risk to suffer the related symptoms after consuming dry fermented sausages. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Potential negative effects of anti-histamines on male reproductive function.

    PubMed

    Mondillo, Carolina; Varela, María Luisa; Abiuso, Adriana María Belén; Vázquez, Ramiro

    2018-05-01

    Histamine (HA) is a pleiotropic biogenic amine synthesized exclusively by histidine decarboxylase (HDC) in most mammalian tissues. The literature on the role of HA within the male gonad has expanded over the last years, attracting attention to potential unexpected side-effects of anti-histamines on testicular function. In this regard, HA receptors (HRH1, HRH2 and HRH4) have been described in Leydig cells of different species, including human. Via these receptors, HA has been reported to trigger positive or negative interactions with the LH/hCG signaling pathway depending upon its concentration, thereby contributing to the local control of testicular androgen levels. It should then be considered that anti-histamines may affect testicular homeostasis by increasing or decreasing steroid production. Additionally, HRH1 and HRH2 receptors are present in peritubular and germ cells, and HRH2 antagonists have been found to negatively affect peritubular cells and reduce sperm viability. The potential negative impact of anti-histamines on male reproduction becomes even more dramatic if we consider that HA has also been associated with human sexual behavior and penile erection. What is more, although testicular mast cells are the major source of locally produced HA, recent studies have described HDC expression in macrophages, Leydig cells and germ cells, revealing the existence of multiple sources of HA within the testis. Undoubtedly, the more we learn about the testicular histaminergic system, the more opportunities there will be for rational design of drugs aimed at treating HA-related pathologies, with minimum or nule negative impact on fertility. © 2018 Society for Reproduction and Fertility.

  11. Are patient decision aids the best way to improve clinical decision making? Report of the IPDAS Symposium.

    PubMed

    Holmes-Rovner, Margaret; Nelson, Wendy L; Pignone, Michael; Elwyn, Glyn; Rovner, David R; O'Connor, Annette M; Coulter, Angela; Correa-de-Araujo, Rosaly

    2007-01-01

    This article reports on the International Patient Decision Aid Standards Symposium held in 2006 at the annual meeting of the Society for Medical Decision Making in Cambridge, Massachusetts. The symposium featured a debate regarding the proposition that "decision aids are the best way to improve clinical decision making.'' The formal debate addressed the theoretical problem of the appropriate gold standard for an improved decision, efficacy of decision aids, and prospects for implementation. Audience comments and questions focused on both theory and practice: the often unacknowledged roots of decision aids in expected utility theory and the practical problems of limited patient decision aid implementation in health care. The participants' vote on the proposition was approximately half for and half against.

  12. Mast cells and histamine alter intestinal permeability during malaria parasite infection.

    PubMed

    Potts, Rashaun A; Tiffany, Caitlin M; Pakpour, Nazzy; Lokken, Kristen L; Tiffany, Connor R; Cheung, Kong; Tsolis, Renée M; Luckhart, Shirley

    2016-03-01

    Co-infections with malaria and non-typhoidal Salmonella serotypes (NTS) can present as life-threatening bacteremia, in contrast to self-resolving NTS diarrhea in healthy individuals. In previous work with our mouse model of malaria/NTS co-infection, we showed increased gut mastocytosis and increased ileal and plasma histamine levels that were temporally associated with increased gut permeability and bacterial translocation. Here, we report that gut mastocytosis and elevated plasma histamine are also associated with malaria in an animal model of falciparum malaria, suggesting a broader host distribution of this biology. In support of mast cell function in this phenotype, malaria/NTS co-infection in mast cell-deficient mice was associated with a reduction in gut permeability and bacteremia. Further, antihistamine treatment reduced bacterial translocation and gut permeability in mice with malaria, suggesting a contribution of mast cell-derived histamine to GI pathology and enhanced risk of bacteremia during malaria/NTS co-infection. Copyright © 2015 Elsevier GmbH. All rights reserved.

  13. Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans.

    PubMed

    Romero, Steven A; Ely, Matthew R; Sieck, Dylan C; Luttrell, Meredith J; Buck, Tahisha M; Kono, Jordan M; Branscum, Adam J; Halliwill, John R

    2015-04-01

    What is the central question of this study? Is exercise-induced oxidative stress the upstream exercise-related signalling mechanism that leads to sustained postexercise vasodilatation via activation of H1 and H2 histamine receptors? What is the main finding and its importance? Systemic administration of the antioxidant ascorbate inhibits sustained postexercise vasodilatation to the same extent as seen previously with H1 and H2 histamine receptor blockade following small muscle-mass exercise. However, ascorbate has a unique ability to catalyse the degradation of histamine. We also found that systemic infusion of the antioxidant N-acetylcysteine had no effect on sustained postexercise vasodilatation, suggesting that exercise-induced oxidative stress does not contribute to sustained postexercise vasodilatation. An acute bout of aerobic exercise elicits a sustained postexercise vasodilatation that is mediated by histamine H1 and H2 receptor activation. However, the upstream signalling pathway that leads to postexercise histamine receptor activation is unknown. We tested the hypothesis that the potent antioxidant ascorbate would inhibit this histaminergic vasodilatation following exercise. Subjects performed 1 h of unilateral dynamic knee extension at 60% of peak power in three conditions: (i) control; (ii) i.v. ascorbate infusion; and (iii) ascorbate infusion plus oral H1 /H2 histamine receptor blockade. Femoral artery blood flow was measured (using Doppler ultrasound) before exercise and for 2 h postexercise. Femoral vascular conductance was calculated as flow/pressure. Postexercise vascular conductance was greater for control conditions (3.4 ± 0.1 ml min(-1) mmHg(-1) ) compared with ascorbate (2.7 ± 0.1 ml min(-1) mmHg(-1) ; P < 0.05) and ascorbate plus H1 /H2 blockade (2.8 ± 0.1 ml min(-1) mmHg(-1) ; P < 0.05), which did not differ from one another (P = 0.9). Given that ascorbate may catalyse the degradation of histamine in vivo, we conducted a follow-up study

  14. Comparison of capnovolumetry-derived dead space parameters with pulmonary function test in normal adults using histamine provocation.

    PubMed

    Sun, Xiaoli; Zhang, Yan; Yang, Wenlan; Liu, Jinming

    2015-04-01

    This study in healthy adults was conducted to explore the clinical application of capnovolumetric indices as compared to lung function parameters using histamine provocation. Forty healthy subjects received aerosol histamine or salbutamol in an automatic stimulation system with escalating doses of histamine. Dead space volumes of capnovolumetry and lung function parameters were examined with increased concentrations of histamine at a fixed time interval. The doses of histamine were selected from 0.0562 mg-2.2 mg and 0.1 mg salbutamol was inhaled when a maximal dose of histamine was reached. Baseline values in each group were calculated prior to histamine inhalation. Fowler dead space (VDF), Wolff dead space (VDW), threshold dead space (VDT), Bohr dead space (VDB), forced expiratory volume in 1 s (FEV1 ) and peak expiratory flow (PEF) showed a dose-dependent reduction following histamine provocation, but there were no statistical differences in the measurements at baseline and post S6 provocation. The value of dC3/DV at the maximal dose was significantly increased over its baseline value (P < 0.05). VDF, VDT and VDW were significantly increased after bronchodilator use (P < 0.05 or <0.01). The changes in capnovolumetry did not correspond with the results of lung function test. The dC3/DV and airway dead spaces of capnovolumetry in healthy adults are significantly increased compared to lung function parameters before or after bronchodilator use, suggesting that capnovolumetry is feasible in diagnostic evaluation of airway reactivity, especially for persons who are unable to undertake lung function test. © 2014 John Wiley & Sons Ltd.

  15. Effects of histamine and 5-hydroxytryptamine on the growth rate of xenografted human bronchogenic carcinomas.

    PubMed

    Sheehan, P F; Baker, T; Tutton, P J; Barkla, D H

    1996-01-01

    1. The influence of histamine and 5-hydroxytryptamine (5-HT) antagonists and agonists on the volume doubling times (Td) of human bronchogenic carcinomas propagated as s.c. xenografts in immunosuppressed mice was examined. 2. The H2-receptor antagonists, cimetidine and ranitidine, increased Td. 3. Treatment with the H2-receptor agonist, 4-methyl histamine, had no effect on Td. 4. Co-administration of 4-methyl histamine and cimetidine abolished the effects of cimetidine. 5. The 5-HT2-receptor antagonists, cinanserin and ketanserin, both increased Td. 6. Treatment with the 5-HT1/2-receptor agonist quipazine (0.1 mg/kg, reflecting 5-HT2 agonist activity) decreased Td, while a higher dose (10.0 mg/kg) had no effect. 7. The 5-HT1/2-receptor antagonist, methiothepin, decreased Td. 8. The 5-HT uptake inhibitor, fluoxetine, increased Td in one tumour line but not in another, while the 5-HT releaser/depletor, fenfluramine, increased Td. 9. Histamine may stimulate tumour growth through the histamine H2-receptor, while the dominant effect of 5-HT is 5-HT1-receptor inhibition. 10. Tumour growth in some bronchogenic carcinomas may involve 5-HT uptake mechanisms.

  16. PREFACE: 10th International LISA Symposium

    NASA Astrophysics Data System (ADS)

    Ciani, Giacomo; Conklin, John W.; Mueller, Guido

    2015-05-01

    The LISA Symposia have become a mainstay of the gravitational wave community. Held every two years, they are the prime opportunity for our community to discuss the exciting science, technology, mission designs, and progress of the Laser Interferometer Space Antenna. The 8th LISA symposium, held at Stanford University in the summer of 2010 was the largest symposium so far and was dominated by progress and hopes that the LISA mission will soon excel following the expected launch of the LISA pathfinder (LPF), no later than 2012, and the expected prioritization by the Decadal survey which was released 6 weeks later. The following years were challenging. Although the Decadal survey ranked LISA very high, NASA's budget issues, mostly due to the cost increase of the James Webb Space Telescope, and continued delays in LPF put too much stress on the LISA project and it officially ended in 2011. The LISA International Science Team (LIST), the core group of LISA scientists and technologists, was dissolved and the community in the U.S. was struggling to maintain cohesion. In the wake of these events, ESA started a new selection process for their next three large missions, L1, L2, and L3, and the European LISA team developed the New Gravitational wave Observatory (NGO), an evolved LISA concept, as an ESA only L1 candidate. A few weeks before the 9th LISA Symposium, held in Paris in May 2012, ESA announced its decision to select JUICE, a planetary mission to Jupiter and its moons, as its next large science mission (L1). Despite having the highest ranked science case, NGO was not selected due to further delays in LPF and the general feeling outside the GW community that the technology is perhaps too challenging to be pulled off in time for the L1 launch in 2022. Many U.S. members of the LISA community cancelled their travel plans and the mood at that symposium ranged from resignation to defiance. Hope for a somewhat timely launch of a LISA-like mission rested upon L2, the next

  17. Asia Federation Report on International Symposium on Grid Computing 2009 (ISGC 2009)

    NASA Astrophysics Data System (ADS)

    Grey, Francois

    This report provides an overview of developments in the Asia-Pacific region, based on presentations made at the International Symposium on Grid Computing 2009 (ISGC 09), held 21-23 April. This document contains 14 sections, including a progress report on general Asia-EU Grid activities as well as progress reports by representatives of 13 Asian countries presented at ISGC 09. In alphabetical order, these are: Australia, China, India, Indonesia, Japan, Malaysia, Pakistan, Philippines, Singapore, South Korea, Taiwan, Thailand and Vietnam.

  18. PREFACE: Fullerene Nano Materials (Symposium of IUMRS-ICA2008)

    NASA Astrophysics Data System (ADS)

    Miyazawa, Kun'ichi; Fujita, Daisuke; Wakahara, Takatsugu; Kizuka, Tokushi; Matsuishi, Kiyoto; Ochiai, Yuichi; Tachibana, Masaru; Ogata, Hironori; Mashino, Tadahiko; Kumashiro, Ryotaro; Oikawa, Hidetoshi

    2009-07-01

    This volume contains peer-reviewed invited and contributed papers that were presented in Symposium N 'Fullerene Nano Materials' at the IUMRS International Conference in Asia 2008 (IUMRS-ICA 2008), which was held on 9-13 December 2008, at Nagoya Congress Center, Nagoya, Japan. Over twenty years have passed since the discovery of C60 in 1985. The discovery of superconductivity of C60 in 1991 suggested infinite possibilities for fullerenes. On the other hand, a new field of nanocarbon has been developed recently, based on novel functions of the low-dimensional fullerene nanomaterials that include fullerene nanowhiskers, fullerene nanotubes, fullerene nanosheets, chemically modified fullerenes, endohedral fullerenes, thin films of fullerenes and so forth. Electrical, electrochemical, optical, thermal, mechanical and various other properties of fullerene nanomaterials have been investigated and their novel and anomalous nature has been reported. Biological properties of fullerene nanomaterials also have been investigated both in medical applications and toxicity aspects. The recent research developments of fullerene nanomaterials cover a variety of categories owing to their functional diversity. This symposium aimed to review the progress in the state-of-the-art technology based on fullerenes and to offer the forum for active interdisciplinary discussions. 24 oral papers containing 8 invited papers and 22 poster papers were presented at the two-day symposium. Topics on the social acceptance of nanomaterials including fullerene were presented on the first day of the symposium. Biological impacts of nanomaterials and the importance of standardization of nanomaterials characterization were also shown. On the second day, the synthesis, properties, functions and applications of various fullerene nanomaterials were shown in both the oral and poster presentations. We are grateful to all invited speakers and many participants for valuable contributions and active discussions

  19. Climate Science and Technology Symposium

    DTIC Science & Technology

    2010-01-06

    at the Roger Revelle Centennial Symposium, the scientific focus of Scripps Institution of Oceanography’s celebration of Roger Revelle’s 100th...the Roger Revelle Centennial Symposium honored Revelle’s continuing legacy, and highlighted the influence his work continues to exert upon the...view the Roger Revelle Centennial Symposium on UCSD-TV, visit ucsd.tv/revellesymposium warn SYMPOSIUM REPORT ROGER REVELLE 100 TH BIRTHDAY

  20. Proceedings of the symposium on multiple-use managementof California's hardwood resources; November 12-14, 1986; San Luis Obispo, California

    Treesearch

    Timothy R. Plumb; Norman H. Pillsbury

    1987-01-01

    The Symposium on the Ecology, Management, and Utilization of California Oaks held in June 1979 at Claremont, California, was the first to take a comprehensive look at California's native oak resource. At that time, interest in several species of California oaks was rapidly growing with particular concern about their regeneration, preservation, and wildlife...

  1. In search of acceptable alternatives to the murine histamine sensitisation test (HIST): what is possible and practical?

    PubMed

    Wagner, L; Isbrucker, R; Locht, C; Arciniega, J; Costanzo, A; McFarland, R; Oh, H; Hoonakker, M; Descamps, J; Andersen, S R; Gupta, R K; Markey, K; Chapsal, J M; Lidster, K; Casey, W; Allen, D

    2016-01-01

    The 'International Workshop on Alternatives to the Murine Histamine Sensitization Test for Acellular Pertussis Vaccines: In Search of Acceptable Alternatives to the Murine Histamine Sensitization Test (HIST): What is Possible and Practical?' was held on 4 and 5 March 2015 in London, United Kingdom. Participants discussed the results of the data generated from an international collaborative study (BSP114 Phase 2) sponsored by the European Directorate for the Quality of Medicines & Health Care (EDQM) to determine if a modified Chinese hamster ovary (CHO) cell-based clustering assay is a suitable alternative to replace HIST. Workshop participants agreed that protocol transferability demonstrated in the collaborative study indicates that a standardised CHO cell assay is adequate for measuring pure PTx in reference preparations. However, vaccine manufacturers would still need to demonstrate that the method is valid to detect or measure residual PTx in their specific adjuvanted products. The 2 modified CHO cell protocols included in the study (the Direct and the Indirect Methods) deserve further consideration as alternatives to HIST. Using the CHO cell assay, an in vitro alternative, for acellular pertussis (aP) vaccine batch release testing would reduce the number of animals used for aP vaccine safety testing. A strategic, stepwise adoption plan was proposed, in which the alternative test would be used for release purposes first, and then, once sufficient confidence in its suitable performance has been gained, its use would be extended to stability testing.

  2. Program Abstracts Sparse Matrix Symposium 1982 Held at Fairfield Glade, Tennessee, October 24-27, 1982,

    DTIC Science & Technology

    1982-01-01

    near EL t1 !i (lr,’. 11:40 Robert Fourer, ’,n viri, ’,: r;t- t..iir, i S, ,e Gaussian Fl i in nation. *Presenter of paper. * Poster Session op .) d i n a...Systems of Linear Inequalities." ’:10 End of Symposium. Poster Session. Wilshire-Canterbury-Windsor Room ( Posters on display Monday and Tuesday) D. A...p.m. / Tues. l-, r,4e, *ltan OB 33 12:30-12:50 p.m. / Tues. i:)e rt, Jenn K A :5U- 8:10 p.m. / Tues. I, es, ,lanes Lb2 Poster Monday - Tuesday . , , Pn

  3. Preface: 5th International Symposium on the Interface between Analytical Chemistry and Microbiology - April 19th to 21st, 2004: Hosted at Pacific Northwest National Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Allmaier, Guenter; Wunschel, David S.; Wahl, Karen L.

    2004-04-19

    This is an introduction to a special issue of the Journal of microbiological Methods based on a recent meeting held at PNNL: the 5th International Symposium on the Interface between Analytical Chemistry and Microbiology.

  4. Scalp stratum corneum histamine levels: novel sampling method reveals association with itch resolution in dandruff/seborrhoeic dermatitis treatment.

    PubMed

    Kerr, Kathy; Schwartz, James R; Filloon, Thomas; Fieno, Angela; Wehmeyer, Ken; Szepietowski, Jacek C; Mills, Kevin J

    2011-06-01

    Dandruff and seborrhoeic dermatitis are accompanied by bothersome itch. We have established a novel non-invasive methodology to sample histamine levels in the stratum corneum in order to facilitate an understanding of pruritogenesis in this condition. Histamine levels were assessed in two groups of subjects with dandruff before and after 3 weeks of treatment with a commercial potentiated zinc pyrithione shampoo. A comparative population without dandruff was also studied. Itch self-perception was quantified on a visual analogue scale. The histamine level in subjects with dandruff was more than twice that in those who did not have dandruff. Under conditions known to resolve flaking symptoms, the shampoo led to a reduction in histamine in subjects with dandruff to a level that was statistically indistinguishable from those who did not have dandruff. This reduction in histamine was accompanied by a highly significant reduction in the perception of itch intensity. These findings suggest an association between the subjective perception of itch in the scalp and the level of histamine in the skin.

  5. The control effect of histamine on body temperature and respiratory function in IgE-dependent systemic anaphylaxis.

    PubMed

    Makabe-Kobayashi, Yoko; Hori, Yoshio; Adachi, Tetsuya; Ishigaki-Suzuki, Satsuki; Kikuchi, Yoshihiro; Kagaya, Yutaka; Shirato, Kunio; Nagy, András; Ujike, Azusa; Takai, Toshiyuki; Watanabe, Takehiko; Ohtsu, Hiroshi

    2002-08-01

    The systemic anaphylaxis reaction comprises various symptoms, including hypotension, changes in respiration pattern, and hypothermia. To elucidate the role of histamine in each of these symptoms, we induced the passive systemic anaphylaxis reaction in histidine decarboxylase gene knockout (HDC [-/-]) mice, which lack histamine. HDC(-/-) mice were generated by knocking out the HDC gene, which codes for the unique histamine-synthesizing enzyme. Twenty-four hours after the injection of IgE, HDC(+/+) and HDC(-/-) mice were injected with allergen and body temperature, blood pressure, and respiratory function were monitored in each mouse. Blood pressure dropped in both the HDC(-/-) mice and the HDC(+/+) mice. In contrast, respiratory frequency dropped and the expiratory respiration time was elongated only in the HDC(+/+) mice. Body temperature was decreased in the HDC(+/+) mice and was practically unchanged in the HDC(-/-) mice. Histamine receptor antagonists blocked the body temperature drop in the HDC(+/+) mice. Intravenous histamine induced similar patterns of body temperature decrease in the HDC(+/+) mice and the HDC(-/-) mice. Mast cell-deficient W/W (v) mice did not show the decrease in body temperature; this suggests that the histamine that contributed to the decrease in body temperature was derived from mast cells. According to the results of this investigation, in the passive systemic anaphylaxis reaction, respiratory frequency, expiratory time, and body temperature are shown to be controlled by the activity of histamine, but its contribution to blood pressure is negligible.

  6. Histamine H4 receptor in oral lichen planus.

    PubMed

    Salem, A; Al-Samadi, A; Stegajev, V; Stark, H; Häyrinen-Immonen, R; Ainola, M; Hietanen, J; Konttinen, Y T

    2015-04-01

    Oral lichen planus (OLP) is an autoimmune disease characterized by a band-like T-cell infiltrate below the apoptotic epithelial cells and degenerated basement membrane. We tested the hypothesis that the high-affinity histamine H4 receptors (H4 Rs) are downregulated in OLP by high histamine concentrations and proinflammatory T-cell cytokines. Immunohistochemistry and immunofluorescence staining, image analysis and quantitative real-time polymerase chain reaction of tissue samples and cytokine-stimulated cultured SCC-25 and primary human oral keratinocytes. H4 R immunoreactivity was weak in OLP and characterized by mast cell (MC) hyperplasia and degranulation. In contrast to controls, H4 R immunostaining and MC counts were negatively correlated in OLP (P = 0.003). H4 R agonist at nanomolar levels led to a rapid internalization of H4 Rs, whereas high histamine concentration and interferon-γ decreased HRH4 -gene transcripts. Healthy oral epithelial cells are equipped with H4 R, which displays a uniform staining pattern in a MC-independent fashion. In contrast, in OLP, increased numbers of activated MCs associate with increasing loss of epithelial H4 R. Cell culture experiments suggest a rapid H4 R stimulation-dependent receptor internalization and a slow cytokine-driven decrease in H4 R synthesis. H4 R may be involved in the maintenance of healthy oral mucosa. In OLP, this maintenance might be impaired by MC degranulation and inflammatory cytokines. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. Space Symposium/76

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A symposium dealing with career opportunities in the aerospace program for minorities was conducted and evaluated. The symposium was attended by students from eleven predominantly minority colleges and universities in and around Washington, D. C. and the eastern region, and from high schools in five jurisdictions of the Washington metropolitan area. Speakers included representatives of Howard University, NASA, and private industry. On display during the symposium was a NASA exhibit of moon rocks, space shuttles, a lunar module, command module, pacemaker, LANDSAT, and other items of interest.

  8. Factors associated with negative histamine control for penicillin allergy skin testing in the inpatient setting.

    PubMed

    Geng, Bob; Thakor, Ami; Clayton, Elisabeth; Finkas, Lindsay; Riedl, Marc A

    2015-07-01

    Identification of factors adversely affecting the utility of allergy skin testing is important in optimizing patient care. Inpatient penicillin skin test data from 1997 through 2007 demonstrate that up to 20% of attempted penicillin skin tests are indeterminate owing to a negative histamine test response, despite exclusion of H1 antagonists. Critical illness, vasopressors, steroid use, and psychotropic medications have been postulated to influence outcomes, but large studies are lacking. To identify factors associated with a negative histamine test response for the inpatient setting. Fifty-two cases were identified with a negative histamine response after penicillin skin testing in the absence of antihistamine therapy for 72 hours before testing. One hundred twenty-five controls with a normal histamine response were randomly selected from same population. Independent variables assessed included stay in the intensive care unit (ICU), skin color, diabetes, age, use of vasopressors, H2 blocker, steroids, other immunosuppressive drugs, thyroid replacement, proton pump inhibitors, diuretics, 5 categories of psychotropic medications, and amiodarone. Mean age was 68 years for cases vs 60 years for controls (P = .002). Bivariate analysis showed ICU stay was more frequent in cases than in controls (73.1% vs 33.6%, P < .001). Regression analysis yielded odds ratios (ORs) of 8.18 (95% confidence interval 3.22-20.76) for ICU status, 3.76 (1.30-10.92) for systemic corticosteroids, and 4.90 (1.17-20.62) for H2 blockers as associated with lack of histamine response. For every additional year in age, there was increase in the OR of 1.04 (1.01-1.07). Regression analysis supports ICU stay during skin testing as associated with a high OR for a negative histamine response independent of age. Systemic corticosteroids, H2 blockers, and older age are associated with a significant OR for a negative histamine response. This is one of largest studies on factors associated with a negative

  9. Histamine development and bacterial diversity in microbially-challenged tonggol (Thunnus tonggol) under temperature abuse during canning manufacture.

    PubMed

    Hongpattarakere, Tipparat; Buntin, Nirunya; Nuylert, Aem

    2016-01-01

    Histamine formation and bacteriological changes caused by temperature abuse commonly occurring in the manufacturing process of standard canned tuna was assessed in microbiologically challenged tonggol (Thunnus tonggol). The in situ challenge was performed by water-soaking at 26-28 °C for 7 h to ensure the multiplication and active phase of fish microflora. Right after pre-cooking to back-bone temperature (BBT) of 50-52 °C, histamine dropped to 5.17 ± 2.71 ppm, and slowly reached 6.84 ± 1.69 ppm at 16 h abuse. On the contrary, histamine was reduced to 2.87 ± 1.23 ppm and eventually reached 5.01 ± 1.32 ppm at 24 h abuse in the pre-cooked fish previously frozen. The numbers of total aerobic bacteria, Enterobactericeae, psychrotroph, histamine forming bacteria (HFB) and diversity of fish microflora were revealed by cultural and nested PCR-Denaturing Gradient Gel Electrophoresis (PCR-DGGE) techniques. Interestingly, frozen storage effectively halted histamine formation in raw fish throughout 16 h abuse despite the presence of HFB. These included the prolific strains of Morganella morganii, Proteus penneri, Proteus mirabilin, Citrobacter spp. The nested PCR-DGGE profile confirmed the presence of M. morganii and Citrobacter spp. in raw fish. These prolific strains were hardly observed in the precooked fish previously frozen. Frozen storage did not only promote even histamine distribution throughout fish muscle but also enhanced histamine loss during thawing and pre-cooking. Therefore, pre-cooking and frozen storage were proven to be the effective combined hurdles not only to reduce but also prolong histamine formation of the challenged toggol throughout 24 h of temperature abuse during canning process.

  10. Proceedings of Symposium Lipid Mediators in Immunology of Shock Held in Copenhagen, Denmark 21-25 July 1986

    DTIC Science & Technology

    1989-07-01

    MONITORING ORGANIZATION REPORT NUMBER(S) Ga . NAME OF PERFORMING ORGANIZATION 6b. OFFICE SYMBOL 7a. NAME OF MONITORING ORGANIZATION NATO Symposium...is a brief consideration of several new drugs which may prove to be valua- ble therapeutic agents in trauma, shock and related conditions. In...Bertrand, M. Lismonde Vol Detection of Pentane as a Measurement of Lipid Peroxidation in Humans Using Gas Chromatography With a Photoionization Detector

  11. The multi-facets of sustainable nanotechnology - Lessons from a nanosafety symposium.

    PubMed

    George, Saji; Ho, Shirley S; Wong, Esther S P; Tan, Timothy Thatt Yang; Verma, Navin Kumar; Aitken, Robert J; Riediker, Michael; Cummings, Christopher; Yu, Liya; Wang, Zheng Ming; Zink, Daniele; Ng, Zhihan; Loo, Say Chye Joachim; Ng, Kee Woei

    2015-05-01

    An international symposium for nanosafety was held recently at the Nanyang Technological University in Singapore. Topics relating to understanding nanomaterial properties, tools, and infrastructure required for predicting hazardous outcomes, measuring nanomaterial exposure levels, systems approach for risk assessment and public's perception of nanotechnology were covered. The need for a multidisciplinary approach, across both natural and social sciences, for developing sustainable nanotechnology solutions was heavily emphasized. This commentary highlights the major issues discussed and the commitment of the nanosafety research community in Singapore to contribute collectively to realise the vision of sustainable nanotechnology.

  12. International symposium on clusters and nanomaterials (energy and life-sciences applications)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jena, Purusottam

    The International Symposium on Clusters and Nanomaterials was held in Richmond, Virginia during October 26-29, 2015. The symposium focused on the roles clusters and nanostructures play in solving outstanding problems in clean and sustainable energy and life sciences applications; two of the most important issues facing science and society. Many of the materials issues in renewable energies, environmental impacts of energy technologies as well as beneficial and toxicity issues of nanoparticles in health are intertwined. Realizing that both fundamental and applied materials issues require a multidisciplinary approach the symposium provided a forum by bringing researchers from physics, chemistry, materials science,more » and engineering fields to share their ideas and results, identify outstanding problems, and develop new collaborations. Clean and sustainable energy sessions addressed challenges in production, storage, conversion, and efficiency of renewable energies such as solar, wind, bio, thermo-electric, and hydrogen. Environmental issues dealt with air- and water-pollution and conservation, environmental remediation and hydrocarbon processing. Topics in life sciences included therapeutic and diagnostic methods as well as health hazards attributed to nanoparticles. Cross-cutting topics such as reactions, catalysis, electronic, optical, and magnetic properties were also covered. The symposium attracted 132 participants from 24 countries in the world. It featured 39 invited speakers in 14 plenary sessions, in addition to one key-note session. Eighty-five contributed papers were presented in two poster sessions and 14 papers from this list were selected to be presented orally at the end of each session to highlight hot topics. Papers presented at the symposium were reviewed and published in SPIE so that these can reach a wide audience. The symposium was highly interactive with ample time allotted for discussions and making new collaborations. The participants

  13. Dudrick Research Symposium 2015-Lean Tissue and Protein in Health and Disease.

    PubMed

    Earthman, Carrie P; Wolfe, Robert R; Heymsfield, Steven B

    2017-02-01

    The 2015 Dudrick Research Symposium "Lean Tissue and Protein in Health and Disease: Key Targets and Assessment Strategies" was held on February 16, 2015, at Clinical Nutrition Week in Long Beach, California. The Dudrick Symposium honors the many pivotal and innovative contributions to the development and advancement of parenteral nutrition made by Dr Stanley J. Dudrick, physician scientist, academic leader, and a founding member of the American Society for Parenteral and Enteral Nutrition. As the 2014 recipient of the Dudrick award, Dr Carrie Earthman chaired the symposium and was the first of 3 speakers, followed by Dr Robert Wolfe and Dr Steven Heymsfield. The symposium addressed the importance of lean tissue to health and response to disease and injury, as well as the many opportunities and challenges in its assessment at the bedside. Lean tissue assessment is beneficial to clinical care in chronic and acute care clinical settings, given the strong relationship between lean tissue and outcomes, including functional status. Currently available bioimpedance techniques, including the use of bioimpedance parameters, for lean tissue and nutrition status assessment were presented. The connection between protein requirements and lean tissue was discussed, highlighting the maintenance of lean tissue as one of the most important primary end points by which protein requirements can be estimated. The various tracer techniques to establish protein requirements were presented, emphasizing the importance of practical considerations in research protocols aimed to establish protein requirements. Ultrasound and other new and emerging technologies that may be used for lean tissue assessment were discussed, and areas for future research were highlighted.

  14. Neuronal histamine and the interplay of memory, reinforcement and emotions.

    PubMed

    Dere, E; Zlomuzica, A; De Souza Silva, M A; Ruocco, L A; Sadile, A G; Huston, J P

    2010-12-31

    The biogenic amine histamine is an important neurotransmitter-neuromodulator in the central nervous system that has been implicated in a variety of biological functions including thermo- and immunoregulation, food intake, seizures, arousal, anxiety, reward and memory. The review of the pertinent literature indicates that the majority of findings are compatible with the appraisal that the inhibition of histaminergic neurotransmission impairs learning and memory formation, decreases cortical activation and arousal, has a suppressive effect on behavioral measures of fear and anxiety, exponentiates the rewarding effects of drugs of abuse and intracranial brain stimulation. In contrast, the stimulation of histaminergic neurotransmission can ameliorate learning and memory impairments that are associated with various experimental deficit models and pathological conditions. Clinical investigations with patients suffering from neurodegenerative diseases such as Alzheimer's and Parkinson's disease demonstrate pathological alterations in the brain's histaminergic system, which, in some cases are correlated with the severity of cognitive deficits. The role of the brain's histamine system in episodic memory formation and the potential of histamine-related drugs to ameliorate cognitive deficits in early stages of neurodegenerative diseases are discussed. Copyright © 2010 Elsevier B.V. All rights reserved.

  15. PREFACE: 3rd International Symposium ''Optics and its Applications''

    NASA Astrophysics Data System (ADS)

    Calvo, M. L.; Dolganova, I. N.; Gevorgyan, N.; Guzman, A.; Papoyan, A.; Sarkisyan, H.; Yurchenko, S.

    2016-01-01

    The SPIE.FOCUS Armenia: 3rd International Symposium ''Optics and its Applications'' (OPTICS-2015) http://rau.am/optics2015/ was held in Yerevan, Armenia, in the period October 1 - 5, 2015. The symposium was organized by the International Society for Optics and Photonics (SPIE), the Armenian SPIE student chapter with collaboration of the Armenian TC of ICO, the Russian-Armenian University (RAU), the Institute for Physical Research of National Academy of Sciences of Armenia (IPR of NAS), the Greek-Armenian industrial company LT-PYRKAL, and the Yerevan State University (YSU). The Symposium was co-organized by the SPIE & OSA student chapters of BMSTU, the Armenian OSA student chapter, and the SPIE student chapters of Lund University and Wroclaw University of Technology. The symposium OPTICS-2015 was dedicated to the International Year of Light and Light-Based Technologies. OPTICS-2015 was devoted to modern topics and optical technologies such as: optical properties of nanostructures, silicon photonics, quantum optics, singular optics & its applications, laser spectroscopy, strong field optics, biomedical optics, nonlinear & ultrafast optics, photonics & fiber optics, and mathematical methods in optics. OPTICS-2015 was attended by 100 scientists and students representing 17 countries: Armenia, China, Czech Republic, France, Georgia, Germany, India, Iran, Italy, Latvia, Mexico, Poland, Russia, Saudi Arabia, Sweden, Ukraine, and USA. Such a broad international community confirmed the important mission of science to be a uniting force between different countries, religions, and nations. We hope that OPTICS-2015 inspired and motivated students and young scientists to work in optics and in science in general. The present volume of Journal of Physics: Conference Series includes proceedings of the symposium covering various aspects of modern problems in optics. We are grateful to all people who were involved in the organization process. We gratefully acknowledge support from

  16. Degradation of histamine in the presence of ascorbic acid and Cu2+ ion; involvement of hydrogen peroxide.

    PubMed

    Yamamoto, I; Ohmori, H

    1981-01-01

    In the presence, but not in the absence of Cu2+, ascorbate decomposes histamine in citrate phosphate buffer (pH 6.5) at 37 degrees, but not at 0 degrees. The breakdown is completely inhibited by catalase, but only slightly by superoxide dismutase, and scavengers of OH. like benzoic acid, ethanol or potassium iodide. A1 O2 scavenger, alpha-tocopherol also did not show significant effects on the reaction. On the other hand, addition of H2O2 to the reaction mixture markedly enhances the rate of histamine breakdown induced by ascorbate or ascorbate-Cu2+ systems. However, H2O2 alone cannot breakdown histamine even in the presence of Cu2+. Histamine breakdown induced by ascorbate appears to be dependent upon the autooxidation of this vitamin. From these results and the findings reported by Chatterjee et al. that the products of its aerobic oxidation, dehydroascorbic acid and H2O2 were ineffective in reacting with histamine in the presence of Cu2+, it is concluded that the combination of H2O2 and the intermediate of ascorbate oxidation (monodehydroascorbic acid or other unstable species), both of which are produced during the autooxidation of ascorbate, plays a major role in the histamine transformation by ascorbate-Cu2+ system.

  17. Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans

    PubMed Central

    Zdolsek, Johann; Eaton, John W; Tang, Liping

    2007-01-01

    Background Medical implants often fail as a result of so-called foreign body reactions during which inflammatory cells are recruited to implant surfaces. Despite the clinical importance of this phenomenon, the mechanisms involved in these reactions to biomedical implants in humans are not well understood. The results from animal studies suggest that both fibrinogen adsorption to the implant surface and histamine release by local mast cells are involved in biomaterial-mediated acute inflammatory responses. The purpose of this study was to test this hypothesis in humans. Methods Thirteen male medical student volunteers (Caucasian, 21–30 years of age) were employed for this study. To assess the importance of fibrinogen adsorption, six volunteers were implanted with polyethylene teraphthalate disks pre-coated with their own (fibrinogen-containing) plasma or (fibrinogen-free) serum. To evaluate the importance of histamine, seven volunteers were implanted with uncoated disks with or without prior oral administration of histamine receptor antagonists. The acute inflammatory response was estimated 24 hours later by measuring the activities of implant-associated phagocyte-specific enzymes. Results Plasma coated implants accumulated significantly more phagocytes than did serum coated implants and the recruited cells were predominantly macrophage/monocytes. Administration of both H1 and H2 histamine receptor antagonists greatly reduced the recruitment of macrophages/monocytes and neutrophils on implant surfaces. Conclusion In humans – as in rodents – biomaterial-mediated inflammatory responses involve at least two crucial events: histamine-mediated phagocyte recruitment and phagocyte accumulation on implant surfaces engendered by spontaneously adsorbed host fibrinogen. Based on these results, we conclude that reducing fibrinogen:surface interactions should enhance biocompatibility and that administration of histamine receptor antagonists prior to, and shortly after

  18. International Symposium on Optics and its Applications (OPTICS-2011)

    NASA Astrophysics Data System (ADS)

    Bhattacherjee, Aranya B.; Calvo, Maria L.; Kazaryan, Eduard M.; Papoyan, Aram V.; Sarkisyan, Hayk A.

    2012-03-01

    OPTICS Logo PREFACE The papers selected for this volume were reported at the International Symposium 'Optics and its applications' (OPTICS-2011, Yerevan & Ashtarak, Armenia, September 5-9, 2011), http://www.ipr.sci.am/optics2011/. The Symposium was organized by the SPIE Armenian Student Chapter and major Armenian R&D organizations, universities and industrial companies working in the field of basic and applied optics: Institute for Physical Research of the National Academy of Sciences of Armenia, Yerevan State University, Russian-Armenian (Slavonic) University, and LT-PYRKAL Closed Joint Stock Company. OPTICS-2011 was primarily intended to support and promote the involvement of students and young scientists in various fields of modern optics, giving them the possibility to attend invited talks by prominent scientists and to present and discuss their own results. Furthermore, the Symposium allowed foreign participants from 14 countries to become acquainted with the achievements of optical science and technology in Armenia, which became a full member of the International Commission for Optics (ICO) in 2011. To follow this concept, the Symposium sessions were held in various host institutions. The creative and friendly ambience established at OPTICS-2011 promoted further international collaboration in the field and motivated many students to take up research in optics and photonics as a career. This volume of Journal of Physics: Conference Series covers thematic sections of the Symposium (both oral and poster), which represent the main fields of interest in optics for Armenian scientists: quantum optics & information, laser spectroscopy, optical properties of nanostructures, photonics & fiber optics, and optics of liquid crystals. Such wide coverage is consistent with the general scope of the Symposium, allowing all the students involved in optics to present, discuss and publish their recent results, and for those who are making their first steps in science to choose

  19. PREFACE: International Symposium "Nanoscience and Quantum Physics 2011" (nanoPHYS'11)

    NASA Astrophysics Data System (ADS)

    Saito, Susumu; Tanaka, Hidekazu; Nakamura, Takashi; Nakamura, Masaaki

    2011-07-01

    Quantum physics has developed modern views of nature for more than a century. In addition to this traditional role, quantum physics has acquired new significance in the 21st century as the field responsible for driving and supporting nanoscience research, which will have even greater importance in the future because nanoscience will be the academic foundation for new technologies. The Department of Physics, Tokyo Institute of Technology, are now conducting a "Nanoscience and Quantum Physics" project (Physics G-COE project) supported by the Global Center of Excellence Program of the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) in order to promote research and education in these important academic fields. The International Symposium on Nanoscience and Quantum Physics, held in Tokyo, Japan, 26-28 January 2011 (nanoPHYS'11) was organized by the Physics G-COE project of the Tokyo Institute of Technology to provide an international forum for the open exchange of topical information and for stimulating discussion on novel concepts and future prospects of nanoscience and quantum physics. There were a total of 118 papers including 34 invited papers. This nanoPHYS'11 is the fourth symposium of this kind organized by the Tokyo Institute of Technology. Topics focused on in the symposium included: Category 1: Novel nanostructure (Nanowires, Nanotubes, Spin-related structure, etc) Category 2: Novel transport and electronic properties (Graphene, Topological insulators, Coherent control, etc) Category 3: Electronic and optical properties of nanostructure Category 4: Fundamental physics and new concept in quantum physics Category 5: Quantum Physics - Quantum information Category 6: Quantum Physics - Nuclear and Hadron Physics Category 7: Quantum Physics - Astrophysics, etc All the papers submitted to this issue have been reviewed under a stringent refereeing process, according to the normal rules of this Journal. The editors are grateful to all the

  20. Biogenic amine content, histamine-forming bacteria, and adulteration of pork in tuna sausage products.

    PubMed

    Kung, Hsien-Feng; Tsai, Yung-Hsiang; Chang, Shih-Chih; Hong, Tang-Yao

    2012-10-01

    Twenty-five tuna sausage products were purchased from retail markets in Taiwan. The rates of occurrence of biogenic amines, histamine-forming bacteria, and adulteration by pork and poultry were determined. The average content of various biogenic amines in all tested samples was less than 2.0 mg/100 g (<0.05 to 1.85 mg/100 g). Thirteen histamine-producing bacterial strains isolated from tested samples produced 12.1 to 1,261 ppm of histamine in Trypticase soy broth supplemented with 1.0% L-histidine. Among them, Raoultella ornithinolytica (one strain), Enterobacter aerogenes (one strain), and Staphylococcus pasteuri (two strains) were identified as prolific histamine formers. PCR assay revealed that the adulteration rates were 80% (20 of 25) and 4% (1 of 25) for pork and poultry, respectively, in tuna sausage. The fish species in the tuna sausage samples were identified as Thunnus albacares for 22 samples (88%), Thunnus alalunga for 1 sample (4%), and Thunnus thynnus for 1 sample (4%), whereas the remaining sample was identified as Makaira nigricans (blue marlin).