Science.gov

Sample records for holger becker peter

  1. Peter Becker and his Nazi past: the man behind Becker muscular dystrophy and Becker myotonia.

    PubMed

    Zeidman, Lawrence A; Kondziella, Daniel

    2014-04-01

    Peter Becker was a German neurologist who helped classify the muscular dystrophies, and described Becker muscular dystrophy and Becker myotonia. His involvement in National Socialism began in 1933, when he was compelled by his peers to join the SA (brown shirts). He later joined the Nazi party, the Nazi Doctors Association, and the Nazi Lecturers' Association. He renewed his SA membership to maintain his position at a genetics institute. Colleagues stated postwar that he was not an active Nazi, and he was de-Nazified in 1947, able to continue his career. Later, Becker admitted to most, but not all, of his Nazi memberships in his autobiography, and wrote 2 books exploring the origins of Nazism and racial hygiene. The "neurologic court of opinion" must weigh in on how we should best remember Becker, and at the very least, we as neurologists must learn the dangers of career opportunism at any cost. PMID:23576413

  2. Dr. Peter Emil Becker and the Third Reich.

    PubMed

    Hill, Frank

    2013-08-01

    In 1985 the physician after whom Becker Muscular Dystrophy is named, German neurologist Dr. Peter Emil Becker (1908-2000), published an autobiographical article in the American Journal of Medical Genetics in which he disavowed any association with the Nazi Party. A closer look at the evidence, however, suggests otherwise. Review of war records and related sources raise concern for Dr. Becker's affiliation with the Nazi Party and his contributions to its ideology. PMID:23813666

  3. Peter Pan.

    ERIC Educational Resources Information Center

    Storr, Catherine

    1992-01-01

    Offers a contemporary view of J. M. Barrie's life and his classic story, "Peter Pan." Suggests that "Peter Pan" does not really speak for today's children and that the time for Peter Pan's retirement has come. (PRA)

  4. Becker's Nevus Syndrome

    PubMed Central

    Dasegowda, Sathyanarayana B; Basavaraj, GB; Nischal, KC; Swaroop, MR; Umashankar, NP; Swamy, Suchetha S

    2014-01-01

    Becker's nevus is a cutaneous hamartoma characterized by circumscribed hyperpigmentation with hypertrichosis. Becker's nevus syndrome is an association of Becker's nevus with unilateral breast hypoplasia and muscle, skin, and/or skeletal abnormalities. We here report a case of a 15 year-old female who presented with bilateral Becker's nevus over her groins, thighs, vulva, and in front of the neck from the age of 5 years. She had associated mental retardation, delayed development of mile stones, delayed puberty, dwarfism, depressed nasal bridge, long slender digits, crowding of lateral toes, valgus deformity of first metatarsophalangeal joint, mitral valve prolapse, muddy conjunctiva with hypertrophic and hyperpigmented caruncle of both eyes, ichthyosis, brownish hair, and absence of axillary and pubic hair. On histopathological examination collagen hamartoma underneath the Becker's nevus was found. PMID:25071279

  5. Becker muscular dystrophy

    MedlinePlus

    ... and wheelchairs may improve movement and self-care. Genetic counseling may be recommended. Daughters of a man with ... Genetic counseling may be advised if there is a family history of Becker muscular dystrophy.

  6. Polythelia within Becker's naevus.

    PubMed

    Urbani, C E; Betti, R

    1998-01-01

    We report a case of accessory mammary tissue of type 2a (or polythelia) entirely localized within a Becker's naevus of mixed type in a 32-year-old Caucasian woman. Polythelia was congenital in origin while Becker's naevus appeared during puberty. Renal ultrasonographic studies, laboratory examinations and other instrumental investigations were either normal or negative. Although the association of accessory mammary tissue with Becker's naevus has previously been reported--also in the form of mammorenal and acromammorenal syndromes--this is the first case characterized by an anatomic overlap between the two anomalies. It may be the expression of a common disturbance acting early in embryogenesis in the specific developmental fields involved. PMID:9568418

  7. The Federal Art Project: Holger Cahill's Program of Action.

    ERIC Educational Resources Information Center

    Mavigliano, George J.

    1984-01-01

    Under the directorship of Holger Cahill, who drew upon John Dewey's principle of the universal communicability of art, the Federal Art Project of the Great Depression era gave all of the people the opportunity to study and enjoy art. Specific programs of the project are described. (RM)

  8. History's Purpose: Becker or Ortega?

    ERIC Educational Resources Information Center

    Scudder, John R., Jr.; Gulick, Barbara

    1972-01-01

    The transition from a functionally pragmatic interpretation of history to a humanistic existential one is explored by comparing the philosophy of the eminent intellectual historian, Carl Becker, with that of Jose Ortega y Gasset, who interprets history from a humanistic point of view. (Author/SM)

  9. Becker-Blaschke problem of space

    NASA Astrophysics Data System (ADS)

    Bernard, Julien

    2015-11-01

    In a letter to Weyl, Becker proposed a new way to solve the problem of space in the relativistic context. This is the result of Becker's encounter with the two traditions of thinking about space: Husserlian transcendental phenomenology and Blaschke's equiaffine differential geometry. I reconstruct the mathematical content of the Becker-Blaschke solution to the problem of space and highlight the philosophical ideas that guide this construction. This permits me to underline some common properties of Riemannian and Minkowskian manifolds in terms of an unusual notion of isotropy. Finally, I will use this construction as a support to analyze several philosophical differences between Weyl's and Becker's proposals.

  10. The Educational Theory of Ernest Becker.

    ERIC Educational Resources Information Center

    Scimecca, Joseph A.

    1978-01-01

    Ernest Becker developed a theory of education which stressed the liberation of the individual. Based upon the principles of "immortality-striving," i.e., the primacy of the repression of the thought of death, and "self-esteem maintenance," Becker offers an alternative system of education where one's own life, one's own freedom, becomes the basis…

  11. Loving Peter Pan.

    ERIC Educational Resources Information Center

    Kinkaid, James R.

    2003-01-01

    Explores the story of "Peter Pan." Considers its creation, its role on the stage, and its impact on society. Considers how "Peter Pan" is about the inability to have make-believe and the true stick together: it dramatizes an artistic failure, the failure to make the vision of the play successful. (SG)

  12. Remembering Peter Medway

    ERIC Educational Resources Information Center

    Hardcastle, John; Clements, Simon

    2015-01-01

    Peter Medway was an exceptionally able teacher, researcher and thinker, and his work throws light on governments, inspectors and educators. In the early 1960s, Peter met a theory which "established language as a major means of constructing our realities". Later, after teaching English in secondary schools for two decades, he reflected on…

  13. Obituary: Peter E. Brommer

    NASA Astrophysics Data System (ADS)

    Buschow, K. H. J.; de Boer, F. R.; Degiorgi, L.; Jochemsen, R.; Wada, H.; Oostinga, Jeroen; van Wetering, Karine

    2016-07-01

    With great sadness we inform you that Dr P.E. Brommer, editor of Physica B: Condensed Matter Physics has passed away on March 23. Peter has been on the editorial board of the journal for more than 10 years. He was very dedicated to the journal and performed his editorial work with great care and sincerity. For all of us, the opinion and judgment of Peter have always been of crucial importance. We are very grateful for what Peter has meant for the journal. We will enormously miss him.

  14. Genetics Home Reference: Duchenne and Becker muscular dystrophy

    MedlinePlus

    ... Duchenne and Becker muscular dystrophy Duchenne and Becker muscular dystrophy Enable Javascript to view the expand/collapse boxes. Download PDF Open All Close All Description Muscular dystrophies are a group of genetic conditions characterized by ...

  15. Peter Pindar (John Wolcot).

    ERIC Educational Resources Information Center

    Vales, Robert L.

    This book is designed as an introduction to John Wolcot's works for the general reader, the college student, and the college teacher. Wolcot, whose pen name was Peter Pindar, wrote topical satire on public personalities of the eighteenth century, and his methods of criticism are the motif which guides each chapter and which unites all the satires…

  16. Peter Sis: Gifted Creator.

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2003-01-01

    Presents a brief biography of Peter Sis, an author and illustrator of children's books. Includes awards he has won; extension activities; and annotated bibliographies of books written and illustrated by Sis, selected books illustrated by Sis, audiobooks, videorecordings, sources for biographical information, and information on the Web. (LRW)

  17. Cardiomyopathy in becker muscular dystrophy: Overview.

    PubMed

    Ho, Rady; Nguyen, My-Le; Mather, Paul

    2016-06-26

    Becker muscular dystrophy (BMD) is an X-linked recessive disorder involving mutations of the dystrophin gene. Cardiac involvement in BMD has been described and cardiomyopathy represents the number one cause of death in these patients. In this paper, the pathophysiology, clinical evaluations and management of cardiomyopathy in patients with BMD will be discussed. PMID:27354892

  18. Rafał Becker: psychiatrist, eugenist, Zionist.

    PubMed

    Marcinowski, Filip; Nasierowski, Tadeusz

    2016-01-01

    In the interwar period the eugenic ideas gained the status of a scientific theory and become attractive to a wide range of physicians. Among them were doctors of Jewish origin who perceived eugenics as a tool in the fight for biological rebirth of the Jewish nation. Polish-Jewish psychiatrist Raphael Becker (1891-1939?), the author of dozens of scientific papers, was the most famous eugenist among Jewish psychiatrists, not only in Poland but also in Europe. After graduation in medicine at the University in Zurich and training in the psychiatry clinic Burghölzli under the guidance of Eugen Bleuler, Rafał Becker became interested in the question of epidemiology of mental disorders among the Jews. In the interwar period, dealing with the statistics of mental disorders among Polish Jews, and directing a psychiatric hospital "Zofiówka" in Otwock, he significantly contributed to the development of medical care for the mentally ill Jews in Poland. Becker's scientific ideas were greatly influenced by the work of Alfred Adler and Ernst Kretschmer. The article presents the life and scientific achievements of Becker, with particular emphasis on his views on eugenics. PMID:27086342

  19. Cardiomyopathy in becker muscular dystrophy: Overview

    PubMed Central

    Ho, Rady; Nguyen, My-Le; Mather, Paul

    2016-01-01

    Becker muscular dystrophy (BMD) is an X-linked recessive disorder involving mutations of the dystrophin gene. Cardiac involvement in BMD has been described and cardiomyopathy represents the number one cause of death in these patients. In this paper, the pathophysiology, clinical evaluations and management of cardiomyopathy in patients with BMD will be discussed. PMID:27354892

  20. Carl Becker's Modern History: New Roads Barely Trodden.

    ERIC Educational Resources Information Center

    Alpern, Mildred

    1985-01-01

    Reviews the strengths of Kenneth Cooper's updated 1984 edition of Carl Becker's MODERN HISTORY. Contends that while other high school history textbooks sell better, that Becker's text does a better job of teaching European history while helping students develop the advanced academic skills needed for higher education. (JDH)

  1. The Peter What? A Challenge to the Peter Principle

    ERIC Educational Resources Information Center

    Batten, Joe D.

    1971-01-01

    The Peter Principle" is delightful reading particularly for the obsolete or near obsolete person who wants a reassuring palliative for the expedient batch of obsolete practices for which he has opted. (Author/NL)

  2. Peter Elbow's Rhetoric of Reading.

    ERIC Educational Resources Information Center

    Gardiner, Ellen

    1995-01-01

    Claims that Peter Elbow's rhetoric of reading has been oversimplified by applications of taxonomic critiques. Shows how Elbow not only does not ignore the social, but that in fact Elbow's rhetoric tends to try to control it. (HB)

  3. Acido, ergo sum: Holger Hydén--the neuroscientist in Cortázar's Hopscotch.

    PubMed

    Delgado, Guillermo; Estañol, Bruno

    2013-06-01

    The fictional Italian author Morelli is throughout the novel "Hopscotch" (1963) Julio Cortázar's alter ego. This character proposes an unoriginal literary hypothesis in chapter 62. There is an allusion to a particular Swedish that 'is working on a chemical theory of thought.' The Swedish neuroscientist under analysis is Holger Hydén (1917-2000), by then professor and chairman of the Department of Histology at the University of Göteborg. Hydén, who was the first to work in neurobiological micromethods, is mentioned by Morelli due to his participation in a symposium held at the end of January 1961, in San Francisco. His pioneering work will never be completely forgotten, because Hydén's neuroscientific legacy lives and will live in Cortázar's "Hopscotch". PMID:23828537

  4. An Interview with Peter Elbow.

    ERIC Educational Resources Information Center

    Peinado, Kelly

    1997-01-01

    Solicits the opinion of writing specialist Peter Elbow on two-year colleges, whether writing can be taught, whether literature has a place in the composition classroom, and whether teachers with literature degrees make good writing teachers. Discusses what works with developmental writers, and other topics. (PA)

  5. Peter & Jane: A Program Showcase

    ERIC Educational Resources Information Center

    Kalinowski, Michael

    2008-01-01

    This article features the early childhood programs at Peter & Jane Kindergarten located in Petaling Java, Malaysia. The primary purpose of the programs is to lay a strong foundation for a lifelong love of learning in each child. According to principal Patricia Teh, the activities are funded by parent fees and serve children two to six years of…

  6. What Would Peter Drucker Say?

    ERIC Educational Resources Information Center

    Sundre, Steven M.; Raisch, C. Daniel

    2002-01-01

    Applies observations and advice by management guru Peter F. Drucker to the role of school system leaders. Topics include the customer as king, the continually changing definition of success, effective time management, the ethical dimension of decision making, and performance-based leadership (MLF)

  7. Richard Peters and Valuing Authenticity

    ERIC Educational Resources Information Center

    Degenhardt, M. A. B.

    2009-01-01

    Richard Peters has been praised for the authenticity of his philosophy, and inquiry into aspects of the development of his philosophy reveals a profound authenticity. Yet authenticity is something he seems not to favour. The apparent paradox is resolved by observing historical changes in the understanding of authenticity as an important value.…

  8. R. S. Peters and the Periphery

    ERIC Educational Resources Information Center

    Haynes, Bruce

    2013-01-01

    Paul Hirst claimed that Richard Peters "revolutionised philosophy of education". This does not accord with my experience in the Antipodean periphery. My experience of the work of Wittgenstein, Austin and Kovesi before reading Peters and Dewey, Kuhn and Toulmin subsequently meant that Peters was a major but not revolutionary figure in my…

  9. An interview with Peter Lawrence.

    PubMed

    Vicente, Catarina

    2016-01-15

    Peter Lawrence, FRS, is a fly geneticist based at the Department of Zoology at the University of Cambridge. During his illustrious career he has carried out pioneering work on pattern formation and polarity, and his contributions have been recognised by many honours, including the Prince of Asturias prize with Gines Morata and election to the Royal Swedish Academy of Sciences. He is also an outspoken critic of the current scientific system and particularly how it affects young scientists. We recently had the opportunity to chat with Peter, and we asked him about the influence of his mentor Sir V. B. Wigglesworth, writing his first grant at age 65 and his time as an editor of Development. PMID:26786208

  10. On the Generalized Unitary Parasupersymmetry Algebra of Beckers-Debergh

    NASA Astrophysics Data System (ADS)

    Chenaghlou, A.; Fakhri, H.

    An appropriate generalization of the unitary parasupersymmetry algebra of Beckers-Debergh to arbitrary order is presented in this paper. A special representation for realizing the even arbitrary order unitary parasupersymmetry algebra of Beckers-Debergh is analyzed by one-dimensional shape invariance solvable models, 2D and 3D quantum solvable models obtained from the shape invariance theory as well. In particular, in the special representation, it is shown that the isospectrum Hamiltonians consist of the two partner Hamiltonians of the shape invariance theory.

  11. A Hundred Years of Peter Pan

    ERIC Educational Resources Information Center

    Hollindale, Peter

    2005-01-01

    The centenary of the first performance of J. M. Barrie's Peter Pan was celebrated in December 2004. Taking account of the various events in Britain to mark the occasion--newspaper articles, radio and television programmes, retrospects in the original theatre--this article examines the status and popularity of Peter Pan after a hundred years. The…

  12. Why General Education? Peters, Hirst and History

    ERIC Educational Resources Information Center

    White, John

    2009-01-01

    Richard Peters argued for a general education based largely on the study of truth-seeking subjects for its own sake. His arguments have long been acknowledged as problematic. There are also difficulties with Paul Hirst's arguments for a liberal education, which in part overlap with Peters'. Where justification fails, can historical explanation…

  13. Peter H. Rossi: Formative for Program Evaluation

    ERIC Educational Resources Information Center

    Lipsey, Mark W.

    2007-01-01

    This article discusses the significant contributions of Peter H. Rossi to the field of program evaluation. It was the publication of "Evaluation: A Systematic Approach" by Peter Rossi, Howard Freeman, and Sonia Rosenbaum in 1979 that most emphatically marked the point at which program evaluation had clearly consolidated as a distinct field of…

  14. Was Peters Nearly Right about Education?

    ERIC Educational Resources Information Center

    Barrow, Robin

    2009-01-01

    Richard Peters pioneered a form of philosophical analysis in relation to educational discourse that was criticised by some at the time and is today somewhat out of fashion. This paper argues that much of the objection to Peters' methodology is based on a misunderstanding of what it does and does not involve, that consequently philosophical…

  15. Peter Pan: The Text and the Myth.

    ERIC Educational Resources Information Center

    Hollindale, Peter

    1993-01-01

    Shows how the critical reception of J. M. Barrie's "Peter Pan" has varied widely since its publication. Describes the mythical qualities of the Peter Pan character and gives reasons why the story is still popular with children and why it should continue to be taught and read. (HB)

  16. Pearn Peter Niiler (1937-2010)

    NASA Astrophysics Data System (ADS)

    Schmitz, William J., Jr.; Large, William G.

    2011-05-01

    Peter Niiler, great friend, valued colleague, and AGU Fellow since 1986, will be remembered for his scientific achievements and as one of the most colorful physical oceanographers of his generation. Indeed, the Tropic Heat experiment's colors of mauve on pink, complete with Peter's matching ensemble, remain a vivid memory of that otherwise orthodox 1980s program championed by Peter to target equatorial Pacific mixing. Peter always sought understanding: to get things right for the right reason. Therefore, he held a healthy skepticism of numerical modeling and remote sensing, while utilizing both satellites and his own brand of diagnostic modeling. Peter's science motives were noble and would lead him to fight the good fight when necessary, especially when advocating his views on the Gulf Stream path, trapped inertial currents, heat and vorticity balances, and other subjects evoking his passion.

  17. Becker nevus syndrome presented with ipsilateral breast hypoplasia.

    PubMed

    Pektas, Suzan Demir; Akoglu, Gulsen; Metin, Ahmet; Adiyaman, Nuran Sungu; Demirseren, Mustafa Erol

    2014-11-01

    Becker nevus syndrome (BNS) is a rare epidermal nevus syndrome characterized with Becker nevus and ipsilateral breast gland hypoplasia or other skin, skeletal and/or muscle tissue disorders. A 24-year-old woman presented with brown, irregular bordered patch with a diameter of approximately 10 cm which consisted of several small macules on the left breast skin. The ultrasonography and magnetic resonance imaging revealed left breast hypoplasia. Histopathological examination demonstrated minimal acanthosis, papillomatosis, increase in basal layer melanin and hypertrophy of the erector pili muscle. Immunohistochemical staining was positive for androgen in the epidermis, dermal stromal cells and skin appendages. Depending on the clinical and histopathological findings, the patient was diagnosed as BNS. Diagnosis of BNS needs careful examination of pigmented macules and patches since non-hairy BN may be easily overlooked. Patients with BN should be evaluated for associated abnormalities of BNS, in which the severity and extend of ectodermal involvement may differ from patient to other. PMID:25484431

  18. Linkage and mutation analysis of Thomsen and Becker myotonia families

    SciTech Connect

    Koty, P.P.; Pegoraro, E.; Hoffman, E.P.

    1994-09-01

    Thomsen (autosomal dominant) and Becker (autosomal recessive) myotonias are characterized by the inability for muscle relaxation after voluntary, mechanical, or electrical stimulation. Families with both diseases have been linked to the skeletal muscle chloride channel (CLC1) on chromosome 7q35; however, only 2 gene mutations have been identified, and the reasons underlying the alternative dominant or recessive inheritance are not clear. We used linkage analysis and SSCP of 23 exons to screen 8 families (56 individuals) and 7 isolated cases with the diagnosis of Thomsen/Becker myotonia. A novel mutation (1290M) in exon 8 was detected in a family with Thomsen disease. Three additional families showed the previously described G230E change. Thus, chloride channel mutations could be identified in 4/5 families showing dominant inheritance. We were able to exclude linkage to the CLC1 gene in the fifth family. In patients with recessive Becker disease, an isolated case had two unique conformers, one causing a novel A437T change in exon 12. We also identified the previously reported F413C change in a second family. We found significant differences in the clinical picture between families with different mutations but also in families with the same mutation. Our data indicates that DNA studies are critical for correct diagnosis of the myotonias.

  19. Autonomy in R. S. Peters' Educational Theory

    ERIC Educational Resources Information Center

    Cuypers, Stefaan E.

    2009-01-01

    Autonomy is, among other things, an actual psychological condition, a capacity that can be developed, and an educational ideal. This paper contextualises, analyses, criticises and extends the theory of Richard S. Peters on these three aspects of autonomy.

  20. Peter Gabriel Talks With Space Station Crew

    NASA Video Gallery

    Singer-songwriter Peter Gabriel and family visit Mission Control Houston and talk with Expedition 33 Commander Kevin Ford and Flight Engineers Tom Marshburn and Chris Hadfield aboard the Internatio...

  1. Peter Frampton Talks to Station Crew

    NASA Video Gallery

    Rocker Peter Frampton and his band are introduced by astronaut Ron Garan to Commander Mike Fossum and Flight Engineers Satoshi Furukawa and Sergei Volkov aboard the International Space Station duri...

  2. John Peter Zenger, Battler for Freedom

    ERIC Educational Resources Information Center

    Wallerstein, Gerry

    1974-01-01

    Examines the freedom of the press precedent set by the John Peter Zenger case in 1743 and considers its application to such current events as the jailing of reporters for not disclosing news sources. (RB)

  3. First records of Pseudodoros nigricollis Becker (Diptera: Syrphidae) from Cyprus

    PubMed Central

    Makris, Christodoulos

    2016-01-01

    Abstract Background The hoverfly Pseudodoros nigricollis Becker, 1903 is a rarely collected species, of which information on its distribution and ecology is poorly understood. New information In this paper the first records of the hoverfly Pseudodoros nigricollis from Cyprus are provided and discussed. The discovery indicates that this Afrotropical species is approaching the European continent. Short notes on the habitat in which it has been collected are provided. The relationship with the mealy plum aphid Hyalopterus pruni is discussed. Clues on further research are given. PMID:27099565

  4. Whole exome sequence analysis of Peters anomaly.

    PubMed

    Weh, Eric; Reis, Linda M; Happ, Hannah C; Levin, Alex V; Wheeler, Patricia G; David, Karen L; Carney, Erin; Angle, Brad; Hauser, Natalie; Semina, Elena V

    2014-12-01

    Peters anomaly is a rare form of anterior segment ocular dysgenesis, which can also be associated with additional systemic defects. At this time, the majority of cases of Peters anomaly lack a genetic diagnosis. We performed whole exome sequencing of 27 patients with syndromic or isolated Peters anomaly to search for pathogenic mutations in currently known ocular genes. Among the eight previously recognized Peters anomaly genes, we identified a de novo missense mutation in PAX6, c.155G>A, p.(Cys52Tyr), in one patient. Analysis of 691 additional genes currently associated with a different ocular phenotype identified a heterozygous splicing mutation c.1025+2T>A in TFAP2A, a de novo heterozygous nonsense mutation c.715C>T, p.(Gln239*) in HCCS, a hemizygous mutation c.385G>A, p.(Glu129Lys) in NDP, a hemizygous mutation c.3446C>T, p.(Pro1149Leu) in FLNA, and compound heterozygous mutations c.1422T>A, p.(Tyr474*) and c.2544G>A, p.(Met848Ile) in SLC4A11; all mutations, except for the FLNA and SLC4A11 c.2544G>A alleles, are novel. This is the first study to use whole exome sequencing to discern the genetic etiology of a large cohort of patients with syndromic or isolated Peters anomaly. We report five new genes associated with this condition and suggest screening of TFAP2A and FLNA in patients with Peters anomaly and relevant syndromic features and HCCS, NDP and SLC4A11 in patients with isolated Peters anomaly. PMID:25182519

  5. Whole exome sequence analysis of Peters anomaly

    PubMed Central

    Weh, Eric; Reis, Linda M.; Happ, Hannah C.; Levin, Alex V.; Wheeler, Patricia G.; David, Karen L.; Carney, Erin; Angle, Brad; Hauser, Natalie

    2015-01-01

    Peters anomaly is a rare form of anterior segment ocular dysgenesis, which can also be associated with additional systemic defects. At this time, the majority of cases of Peters anomaly lack a genetic diagnosis. We performed whole exome sequencing of 27 patients with syndromic or isolated Peters anomaly to search for pathogenic mutations in currently known ocular genes. Among the eight previously recognized Peters anomaly genes, we identified a de novo missense mutation in PAX6, c.155G>A, p.(Cys52Tyr), in one patient. Analysis of 691 additional genes currently associated with a different ocular phenotype identified a heterozygous splicing mutation c.1025+2T>A in TFAP2A, a de novo heterozygous nonsense mutation c.715C>T, p.(Gln239*) in HCCS, a hemizygous mutation c.385G>A, p.(Glu129Lys) in NDP, a hemizygous mutation c.3446C>T, p.(Pro1149Leu) in FLNA, and compound heterozygous mutations c.1422T>A, p.(Tyr474*) and c.2544G>A, p.(Met848Ile) in SLC4A11; all mutations, except for the FLNA and SLC4A11 c.2544G>A alleles, are novel. This is the frst study to use whole exome sequencing to discern the genetic etiology of a large cohort of patients with syndromic or isolated Peters anomaly. We report five new genes associated with this condition and suggest screening of TFAP2A and FLNA in patients with Peters anomaly and relevant syndromic features and HCCS, NDP and SLC4A11 in patients with isolated Peters anomaly. PMID:25182519

  6. The use of lasers in Becker's naevus: An evidence-based review.

    PubMed

    Momen, Sophie; Mallipeddi, Raj; Al-Niaimi, Firas

    2016-08-01

    Becker's naevus is a hamartoma that often appears during puberty. Clinically this presents with a pigmented and often hairy patch most often on the shoulders. Treatment has always been challenging and lasers are often used with mixed results. This article reviews the evidence of all the laser treatments used in Becker's naevus and analyses the findings from the published studies and trials. PMID:26735085

  7. Peter J Turner: an inventive optometrist.

    PubMed

    Frederikson, Lesley G; Jacobs, Robert J

    2007-11-01

    Machines are Peter Turner's life. They always have been, are now and probably always will be. He can blame his parents for this because despite urging Peter to become an optometrist they gave him inventive genes, a love of technology and holiday work in a factory fitting and turning, and welding. In the 30 years since completing his State Diploma in Optics in New Zealand (SDONZ), Peter has designed and developed three key pieces of optical equipment: a Sun-Following Radio Telescope, a CCTV read/write system and the Berkeley Glare & Acuity Test (BEGAT). He has also completed myriad technological innovations for friends and family ranging from a motorised chair and stand unit for optometric rooms to components for venetian blind manufacturing. PMID:17958574

  8. PEOPLE IN PHYSICS: Interview with Peter Higgs

    NASA Astrophysics Data System (ADS)

    Fancey, Conducted by Norman

    1998-01-01

    Peter Higgs, FRSE, FRS held until recently a personal chair in theoretical physics at the University of Edinburgh and is now an emeritus professor. Peter is well known for predicting the existence of a new particle, the Higgs boson - as yet unconfirmed. He has been awarded a number of prizes in recognition of his work, most recently the Paul Dirac Medal and Prize for outstanding contributions to theoretical physics from the Institute of Physics and the 1997 High Energy and Particle Physics Prize by the European Physical Society.

  9. An Interview with Peter MacDonald.

    ERIC Educational Resources Information Center

    American Indian Journal, 1979

    1979-01-01

    Peter MacDonald, Chairman of the Navajo Nation, the largest tribe in the United States speaks to such issues as energy development/management, oil companies, Navajo-Hopi relocation legislation, traditionalism, and the role of the Council of Energy Resource Tribes. (RTS)

  10. Reading R. S. Peters on Education Today

    ERIC Educational Resources Information Center

    Cuypers, Stefaan E.; Martin, Christopher

    2009-01-01

    This introduction to this special issue offers an overview of R. S. Peters' seminal role in the development of modern philosophy of education, acknowledging the originality and range of his work, and indicating his continuing importance to the field. It explains the structure and organisation of the collection and provides a rationale for this…

  11. Peter Waterman and T-Matrix Methods

    NASA Technical Reports Server (NTRS)

    Mishchenko, M. I.; Martin, P.A.

    2013-01-01

    This paper summarizes the scientific legacy of Peter C. Waterman (1928-2012) who introduced concepts and theoretical techniques that have had a major impact on the fields of scattering by particles and particle groups, optical particletcharacterization, radiative transfer, and remote sensing. A biographical sketch is also included.

  12. Peter Waterman and T-matrix methods

    NASA Astrophysics Data System (ADS)

    Mishchenko, M. I.; Martin, P. A.

    2013-07-01

    This paper summarizes the scientific legacy of Peter C. Waterman (1928-2012) who introduced concepts and theoretical techniques that have had a major impact on the fields of scattering by particles and particle groups, optical particle characterization, radiative transfer, and remote sensing. A biographical sketch is also included.

  13. R. S. Peters: The Reasonableness of Ethics

    ERIC Educational Resources Information Center

    Haynes, Felicity

    2013-01-01

    This article will begin by examining the extent to which R. S. Peters merited the charge of analytic philosopher. His background in social psychology allowed him to become more pragmatic and grounded in social conventions and ordinary language than the analytic philosophers associated with empiricism, and his gradual shift from requiring internal…

  14. The Statue of Liberty Peter Max Style!

    ERIC Educational Resources Information Center

    Cunningham, Kathy

    2012-01-01

    The author's school is only 30 minutes from New York City, so every year when second-graders study towns and cities, the students do a project based on New York City landmarks. This year was the Statue of Liberty. The author introduced Peter Max's famous Pop art to her students, and explained that, as the art world kept changing, artists decided…

  15. Deletion patterns of Duchenne and Becker muscular dystrophies in Greece.

    PubMed Central

    Florentin, L; Mavrou, A; Kekou, K; Metaxotou, C

    1995-01-01

    We present molecular data from 90 Greek boys with Duchenne or Becker muscular dystrophy using cDNA analysis or multiplex PCR or both. Deletions were detected in 63.3% of patients and were mainly clustered in two areas of the gene, one in the 3' and one in the 5' end of the gene (exons 3-19 and 44-53). Almost 17% of deletion breakpoints lay in intron 44 while 29% of deletions have a breakpoint in intron 50. Thus the distribution of deletions in our DMD/BMD patients differs from that previously reported. Furthermore a 1:4.35 proximal:distal ratio was observed in familial cases and a 1:2.45 ratio in isolated ones. PMID:7897627

  16. Obituary: Peter Robert Wilson, 1929-2007

    NASA Astrophysics Data System (ADS)

    Snodgrass, Herschel B.

    2009-01-01

    It is with great sadness that I report the passing of Peter Robert Wilson, a well-known and well-loved figure in the solar physics community. Peter was on the faculty of the Department of Applied Mathematics at the University of Sydney for 39 years, and Chair of the department for 24 of these years. He was the author or co-author of more than 80 scientific research papers and a book, Solar and Stellar Activity Cycles (1994), published by Cambridge University Press. He died suddenly of a heart attack, at his home in Glebe, Australia, in the early morning of 11 November 2007. Peter was an organizer of, and participant in, many international conferences and workshops. He traveled extensively, holding visiting appointments at the University of Colorado (JILA), at Cambridge University, at the College de France (Paris), and at the California Institute of Technology [CalTech]. Most of his work was in the field of solar physics, but he also did some work on the philosophy of science and on tides. Peter came from a line of mathematicians. His father, Robert Wilson, immigrated to Australia from Glasgow in 1911, and became a mathematics teacher at Scotch College, a private school in Melbourne. There his name was changed to 'Bill' because 'Bob' was already taken." Peter's enjoyment of this story as characteristic of Australian academia (as any fan of Monty Python would understand) is indicative of his infectious sense of humor. In a similar vein, he claimed ancestry traced back to the eighteenth-century Scottish mathematician Alexander Wilson, Professor of Astronomy at the University of Glasgow. That Wilson is famous in the solar physics community for his discovery, known as the "Wilson Effect," of the photospheric depressions associated with sunspots. Peter himself could not resist writing a paper on this subject, and was delighted when the bait was taken by some less-informed colleagues who chided him for "naming an effect after himself." "Bill" Wilson married Naomi

  17. Peter Waterman and his scientific legacy

    NASA Technical Reports Server (NTRS)

    Mishchenko, Michael I.; Kahnert, Michael; Mackowski, Daniel W.; Wriedt, Thomas

    2013-01-01

    Peter C. Waterman, a giant figure in the theory of electromagnetic, acoustic, and elastic wave scattering, passed away on 3 June, 2012. In view of his fundamental contributions, which to a large degree have guided the progress of these disciplines over the past five decades and affected profoundly the multifaceted research published in the Journal of Quantitative Spectroscopy and Radiative Transfer (JQSRT), we felt that it would be appropriate to solicit papers for a special issue of JQSRT commemorating Peter Waterman's scientific legacy. This initiative was endorsed by the JQSRT management and has resulted in a representative collection of high-quality papers which have undergone the same peer scrutiny as any paper submitted to JQSRT.

  18. Jim Peters--sportsman, soldier, surgeon.

    PubMed

    Webb, David Rowan

    2013-11-01

    Jim Peters, a country boy who excelled academically and in the sporting arena was a Victorian urological pioneer. His passion for teaching and belief in the development of Australasian urology resulted in the establishment of two of Melbourne's earliest Urology Units (which are now major academic University departments), the creation of a formal urological training program and the promotion of Australian urology within the International urological community. PMID:24127670

  19. Peter V.Hobbs (1936-2005)

    NASA Astrophysics Data System (ADS)

    Wallace, John M.

    Peter Hobbs, a professor in the Department of Atmospheric Sciences at the University of Washington in Seattle, died of pancreatic cancer on 25 July 2005.Born in 1936, Hobbs experienced what he described as “a wild, adventurous youth on the streets of postwar London.” He engaged in competitive swimming and at age 13 held the title of Junior Boxing Champion of the County of Surrey.

  20. Obituary: Peter Robert Wilson, 1929-2007

    NASA Astrophysics Data System (ADS)

    Snodgrass, Herschel B.

    2009-01-01

    It is with great sadness that I report the passing of Peter Robert Wilson, a well-known and well-loved figure in the solar physics community. Peter was on the faculty of the Department of Applied Mathematics at the University of Sydney for 39 years, and Chair of the department for 24 of these years. He was the author or co-author of more than 80 scientific research papers and a book, Solar and Stellar Activity Cycles (1994), published by Cambridge University Press. He died suddenly of a heart attack, at his home in Glebe, Australia, in the early morning of 11 November 2007. Peter was an organizer of, and participant in, many international conferences and workshops. He traveled extensively, holding visiting appointments at the University of Colorado (JILA), at Cambridge University, at the College de France (Paris), and at the California Institute of Technology [CalTech]. Most of his work was in the field of solar physics, but he also did some work on the philosophy of science and on tides. Peter came from a line of mathematicians. His father, Robert Wilson, immigrated to Australia from Glasgow in 1911, and became a mathematics teacher at Scotch College, a private school in Melbourne. There his name was changed to 'Bill' because 'Bob' was already taken." Peter's enjoyment of this story as characteristic of Australian academia (as any fan of Monty Python would understand) is indicative of his infectious sense of humor. In a similar vein, he claimed ancestry traced back to the eighteenth-century Scottish mathematician Alexander Wilson, Professor of Astronomy at the University of Glasgow. That Wilson is famous in the solar physics community for his discovery, known as the "Wilson Effect," of the photospheric depressions associated with sunspots. Peter himself could not resist writing a paper on this subject, and was delighted when the bait was taken by some less-informed colleagues who chided him for "naming an effect after himself." "Bill" Wilson married Naomi

  1. Kabuki syndrome: a new case associated with Becker nevus.

    PubMed

    Cuesta, Laura; Betlloch, Isabel; Toledo, Fernando; Latorre, Nuria; Monteagudo, Almudena Flavia

    2011-01-01

    Kabuki syndrome or Kabuki makeup syndrome was first described in 1981 in Japan by two different groups of authors. These investigators described a group of patients sharing typical facial features, skeletal anomalies, mental retardation, short stature, and dermatoglyphic anomalies. The term Kabuki makeup syndrome was coined because the peculiar facial features of the patients were reminiscent of the Japanese Kabuki theater masks. In 1988, Niikawa et al, after studying 62 patients, proposed five diagnostic criteria for this disease: peculiar facies (in 100% of all patients), skeletal anomalies (92%), dermatoglyphic anomalies (93%), medium to moderate mental retardation (92%), and short stature (83% of all cases). In addition to these findings, a variety of anomalies have been associated with this syndrome - the most serious being cardiac, renal, and urogenital abnormalities. We present a case of Kabuki syndrome in a 6-year-old boy who, in addition to the various features typical of the disease, also exhibited a Becker nevus - a condition not previously associated with this syndrome. The usefulness of dermoscopy in studying alterations in the dermatoglyphic patterns is also discussed. PMID:21906481

  2. Cardiac involvement in Duchenne and Becker muscular dystrophy

    PubMed Central

    Mavrogeni, Sophie; Markousis-Mavrogenis, George; Papavasiliou, Antigoni; Kolovou, Genovefa

    2015-01-01

    Duchenne and Becker muscular dystrophy (DMD/BMD) are X-linked muscular diseases responsible for over 80% of all muscular dystrophies. Cardiac disease is a common manifestation, not necessarily related to the degree of skeletal myopathy; it may be the predominant manifestation with or without any other evidence of muscular disease. Death is usually due to ventricular dysfunction, heart block or malignant arrhythmias. Not only DMD/BMD patients, but also female carriers may present cardiac involvement. Clinically overt heart failure in dystrophinopathies may be delayed or absent, due to relative physical inactivity. The commonest electrocardiographic findings include conduction defects, arrhythmias (supraventricular or ventricular), hypertrophy and evidence of myocardial necrosis. Echocardiography can assess a marked variability of left ventricular dysfunction, independently of age of onset or mutation groups. Cardiovascular magnetic resonance (CMR) has documented a pattern of epicardial fibrosis in both dystrophinopathies’ patients and carriers that can be observed even if overt muscular disease is absent. Recently, new CMR techniques, such as postcontrast myocardial T1 mapping, have been used in Duchenne muscular dystrophy to detect diffuse myocardial fibrosis. A combined approach using clinical assessment and CMR evaluation may motivate early cardioprotective treatment in both patients and asymptomatic carriers and delay the development of serious cardiac complications. PMID:26225202

  3. Functional muscle ischemia in Duchenne and Becker muscular dystrophy

    PubMed Central

    Thomas, Gail D.

    2013-01-01

    Duchenne and Becker muscular dystrophy (DMD/BMD) comprise a spectrum of devastating X-linked muscle wasting disease for which there is no treatment. DMD/BMD is caused by mutations in the gene encoding dystrophin, a cytoskeletal protein that stabilizes the muscle membrane and also targets other proteins to the sarcolemma. Among these is the muscle-specific isoform of neuronal nitric oxide synthase (nNOSμ) which binds spectrin-like repeats within dystrophin's rod domain and the adaptor protein α-syntrophin. Dystrophin deficiency causes loss of sarcolemmal nNOSμ and reduces paracrine signaling of muscle-derived nitric oxide (NO) to the microvasculature, which renders the diseased muscle fibers susceptible to functional muscle ischemia during exercise. Repeated bouts of functional ischemia superimposed on muscle fibers already weakened by dystrophin deficiency result in use-dependent focal muscle injury. Genetic and pharmacologic strategies to boost nNOSμ-NO signaling in dystrophic muscle alleviate functional muscle ischemia and show promise as novel therapeutic interventions for the treatment of DMD/BMD. PMID:24391598

  4. Dystrophin in frameshift deletion patients with Becker Muscular Dystrophy

    SciTech Connect

    Gangopadhyay, S.B.; Ray, P.N.; Worton, R.G.; Sherratt, T.G.; Heckmatt, J.Z.; Dubowitz, V.; Strong, P.N.; Miller, G. ); Shokeir, M. )

    1992-09-01

    In a previous study the authors identified 14 cases with Duchenne muscular dystrophy (DMD) or its milder variant, Becker muscular dystrophy (BMD), with a deletion of exons 3-7, a deletion that would be expected to shift the translational reading frame of the mRNA and give a severe phenotype. They have examined dystrophin and its mRNA from muscle biopsies of seven cases with either mild or intermediate phenotypes. In all cases they detected slightly lower-molecular-weight dystrophin in 12%-15% abundance relative to the normal. By sequencing amplified mRNA they have found that exon 2 is spliced to exon 8, a splice that produces a frameshifted mRNA, and have found no evidence for alternate splicing that might be involved in restoration of dystrophin mRNA reading frame in the patients with a mild phenotype. Other transcriptional and posttranscriptional mechanisms such as cryptic promoter, ribosomal frameshifting, and reinitiation are suggested that might play some role in restoring the reading frame. 34 refs., 5 figs. 1 tab.

  5. Mothers' psychological adaptation to Duchenne/Becker muscular dystrophy.

    PubMed

    Peay, Holly L; Meiser, Bettina; Kinnett, Kathleen; Furlong, Pat; Porter, Kathryn; Tibben, Aad

    2016-05-01

    Duchenne and Becker muscular dystrophy (DBMD) cause significant emotional and care-related burden on caregivers, but no studies have evaluated predictors of positive caregiver outcomes, including disorder-specific psychological adaptation. Using a community-engaged approach focused on supporting mothers in positive aspects of caregiving, this prospective study aims to assess (i) the association between child's baseline functional status and mothers' illness perceptions, resilience, and coping self-efficacy; and (ii) predictors of mothers' psychological adaptation to caring for a child with DBMD. Biological mothers with at least one living child with DBMD completed a baseline survey (n=205) with 1-year (n=147) and 2-year (n=144) follow-up surveys. Worse child's baseline function was associated not only with increased caregiver burden and reduced maternal resilience, but also with perception of positive disease impact on the family. At two follow-ups, increased psychological adaptation to DBMD was predicted by resilience (β=0.264, P=0.001) and perceived positive impact (β=0.310, P<0.001), controlling for mother's age (β=-0.305, P<0.001) and income (β=-0.088, P=0.245). Child's functional status and caregiver burden of DBMD did not predict DBMD-specific adaptation. Though clinicians caring for families with DBMD should anticipate increased caregiver burden as the disorder progresses, interventions focused on caregiver burden are not expected to influence mothers' psychosocial adaptation. Efforts to improve mothers' well-being should focus on fostering mothers' resilience and enhancing perceptions of positive disease impact (benefit finding). Results suggest that psychosocial interventions can highlight strengths and well-being rather than burden and deficit. PMID:26306645

  6. Botanical smuts and hermaphrodites: Lydia Becker, Darwin's botany, and education reform.

    PubMed

    Gianquitto, Tina

    2013-06-01

    In 1868, Lydia Becker (1827-1890), the renowned Manchester suffragist, announced in a talk before the British Association for the Advancement of Science that the mind had no sex. A year later, she presented original botanical research at the BAAS, contending that a parasitic fungus forced normally single-sex female flowers of Lychnis diurna to develop stamens and become hermaphroditic. This essay uncovers the complex relationship between Lydia Becker's botanical research and her stance on women's rights by investigating how her interest in evolutionary theory, as well as her correspondence with Charles Darwin, critically informed her reform agendas by providing her with a new vocabulary for advocating for equality. One of the facts that Becker took away from her work on Lychnis was that even supposedly fixed, dichotomous categories such as biological sex became unfocused under the evolutionary lens. The details of evolutionary theory, from specific arguments on structural adaptations to more encompassing theories on heredity (i.e., pangenesis), informed Becker's understanding of human physiology. At the same time, Becker's belief in the fundamental equality of the sexes enabled her to perceive the distinction between inherent, biological differences and culturally contingent ones. She applied biological principles to social constructs as she asked: Do analogous evolutionary forces act on humans? PMID:23961688

  7. FOREWORD: Peter Clay Eklund: a scientific biography Peter Clay Eklund: a scientific biography

    NASA Astrophysics Data System (ADS)

    Cole, Milton W.; Crespi, Vincent H.; Dresselhaus, Gene F.; Dresselhaus, Mildred S.; Mahan, Gerald D.; Sofo, Jorge O.

    2010-08-01

    Peter Eklund grew up in Southern California and attended the University of California at Berkeley, majoring in physics. After working for one year at the Lockheed Missile and Space Company in Sunnyvale, California, he left to pursue graduate studies at Purdue University. There he carried out PhD research in strongly correlated electron and phonon systems under the supervision of J M Honig and L L van Zandt. Peter joined the group of Millie and Gene Dresselhaus at MIT in 1974 as a Postdoctoral Fellow after one year as an instructor at the University of Kentucky. At MIT, he continued work on strongly correlated systems in collaboration with Professor David Adler (who had an adjoining office), but for the most part he got excited about sp2 carbon systems and graphite intercalation compounds, a new research direction which the Dresselhaus group had started one year before Peter's arrival at MIT. Over the next 35 years Peter, Millie and Gene co-authored over 50 research articles, several review articles, and a big nine-hundred-and-fifty page book. In 1974, they saw graphite intercalation compounds as a long-neglected research direction of great promise. They studied these new materials together over the next 16 years, focusing on their optical spectroscopy. Their pioneering vibrational spectroscopy studies provided a means to characterize the fundamental properties of carbon materials. Optical spectroscopy became a centerpiece in the research portfolios of all three, both when they were together at MIT and after Peter left for the University of Kentucky in 1977 to start his independent career as an Assistant Professor of Physics. Peter became a full Professor at Kentucky in 1986. He continued to work with Millie and Gene and also acquired an ever-expanding network of students, postdocs and collaborators. As each new carbon nanostructure emerged—graphite intercalation compounds, fullerenes, carbon nanotubes, and most recently graphene—Peter was at the cutting edge

  8. Socialization Research in Administration, Graduate School, and Other Professions: The Heuristic Power of Van Gennep and Becker Models.

    ERIC Educational Resources Information Center

    Ronkowski, Shirley; Iannaccone, Laurence

    Ten socialization studies, all of which used Becker's model of perspective shift and/or Van Gennep's three-stage socialization framework were analyzed for common patterns that would add to the empirical and theoretical base of the Becker and Van Gennep models. The studies were concerned with experiences of adults entering and moving through…

  9. 77 FR 33235 - Notice of Realty Action: Modified Competitive Sale of Public Lands in Becker County, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... Bureau of Land Management Notice of Realty Action: Modified Competitive Sale of Public Lands in Becker... parcels of public land totaling 1 acre in Becker County, Minnesota. The sale will be subject to the.... SUPPLEMENTARY INFORMATION: The following two parcels of public land have been examined and found suitable...

  10. Usefulness of sugammadex in a patient with Becker muscular dystrophy and dilated cardiomyopathy.

    PubMed

    Shimauchi, Tsukasa; Yamaura, Ken; Sugibe, Sayaka; Hoka, Sumio

    2014-09-01

    A 54-year-old patient with Becker muscular dystrophy and dilated cardiomyopathy underwent laparoscopic cholecystectomy under total intravenous anesthesia. Muscle relaxation was induced by rocuronium (0.4 mg/kg body weight) under train-of-four (TOF) ratio monitoring. The TOF ratio was 0 at intubation, and 0.2 at the end of surgery. Residual muscle relaxant activity was successfully reversed by sugammadex (2 mg/kg body weight) without any hemodynamic adverse effects (TOF ratio 1.0 at extubation). The clinical and hemodynamic findings suggest that sugammadex can be safely used in patients with Becker muscular dystrophy and dilated cardiomyopathy. PMID:25199695

  11. Theories of Power, Poverty, and Law: In Commemoration of the Contributions of Peter Bachrach--Power, Law, and Final Thoughts: The Contributions of Peter Bachrach

    ERIC Educational Resources Information Center

    Schneider, Elizabeth M.

    2010-01-01

    I am pleased to be part of this symposium to celebrate the life and work of Peter Bachrach. Although my focus is the relevance of Peter's ideas of power to law, I want to begin with some personal comments as well as raise some final thoughts, drawing on others' contributions. Like so many of Peter's other students, I adored him. Peter's joy in…

  12. 77 FR 14773 - Vigue, Peter A.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Vigue, Peter A.; Notice of Filing Take notice that on March 6, 2012, Peter A. Vigue submitted for filing, an application for authority to hold interlocking positions, pursuant...

  13. R. S. Peters' Normative Conception of Education and Educational Aims

    ERIC Educational Resources Information Center

    Katz, Michael S.

    2009-01-01

    This article aims to highlight why R. S. Peters' conceptual analysis of "education" was such an important contribution to the normative field of philosophy of education. In the article, I do the following: 1) explicate Peters' conception of philosophy of education as a field of philosophy and explain his approach to the philosophical analysis of…

  14. Against the Corporate Culture Ideology: An Interview with Peter Mayo

    ERIC Educational Resources Information Center

    Suoranta, Juha

    2010-01-01

    This article presents an interview with Peter Mayo, author and expert in the field of sociology of adult education, on his major influences in this area, his books, and his views on the role of radical adult education and radical scholarship in the future. In the interview, Peter Mayo states that his initial view of adult education was quite a…

  15. 77 FR 26538 - Vigue, Peter A.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... Energy Regulatory Commission Vigue, Peter A.; Notice of Filing Take notice that on April 26, 2012, Peter A. Vigue submitted for filing, a supplement to the application for authority to hold interlocking..., but will not serve to make protestants parties to the proceeding. Any person wishing to become a...

  16. Ritual, Imitation and Education in R. S. Peters

    ERIC Educational Resources Information Center

    Warnick, Bryan R.

    2009-01-01

    This article reconstructs R. S. Peters' underlying theory of ritual in education, highlighting his proposed link between ritual and the imitation of teachers. Rituals set the stage for the imitation of teachers and they invite students to experience practices whose value is not easily discernable from the outside. For Peters, rituals facilitate…

  17. FOREWORD: Peter Clay Eklund: a scientific biography Peter Clay Eklund: a scientific biography

    NASA Astrophysics Data System (ADS)

    Cole, Milton W.; Crespi, Vincent H.; Dresselhaus, Gene F.; Dresselhaus, Mildred S.; Mahan, Gerald D.; Sofo, Jorge O.

    2010-08-01

    Peter Eklund grew up in Southern California and attended the University of California at Berkeley, majoring in physics. After working for one year at the Lockheed Missile and Space Company in Sunnyvale, California, he left to pursue graduate studies at Purdue University. There he carried out PhD research in strongly correlated electron and phonon systems under the supervision of J M Honig and L L van Zandt. Peter joined the group of Millie and Gene Dresselhaus at MIT in 1974 as a Postdoctoral Fellow after one year as an instructor at the University of Kentucky. At MIT, he continued work on strongly correlated systems in collaboration with Professor David Adler (who had an adjoining office), but for the most part he got excited about sp2 carbon systems and graphite intercalation compounds, a new research direction which the Dresselhaus group had started one year before Peter's arrival at MIT. Over the next 35 years Peter, Millie and Gene co-authored over 50 research articles, several review articles, and a big nine-hundred-and-fifty page book. In 1974, they saw graphite intercalation compounds as a long-neglected research direction of great promise. They studied these new materials together over the next 16 years, focusing on their optical spectroscopy. Their pioneering vibrational spectroscopy studies provided a means to characterize the fundamental properties of carbon materials. Optical spectroscopy became a centerpiece in the research portfolios of all three, both when they were together at MIT and after Peter left for the University of Kentucky in 1977 to start his independent career as an Assistant Professor of Physics. Peter became a full Professor at Kentucky in 1986. He continued to work with Millie and Gene and also acquired an ever-expanding network of students, postdocs and collaborators. As each new carbon nanostructure emerged—graphite intercalation compounds, fullerenes, carbon nanotubes, and most recently graphene—Peter was at the cutting edge

  18. Rehabilitation: disability ethics versus Peter Singer.

    PubMed

    McPherson, Gary W; Sobsey, Dick

    2003-08-01

    This commentary discusses utilitarian bioethics currently articulated by Peter Singer, one of the most widely known bioethicists of the 21st century. His controversial concepts of personhood and replaceability have important implications for people with disabilities, caregivers, and rehabilitation in general. Singer suggests that people with severe disabilities should not be considered persons and therefore have no rights or status in ethical issues. In addition, he argues that, although some people with less severe disabilities qualify as persons, their potential quality of life is significantly compromised by disability and therefore it may be ethically desirable to eliminate them so that their resources can be used for someone with superior potential. We reject these ideas, and suggest that those involved in rehabilitation carefully consider these ideas because they imply that rehabilitation is an immoral act unless it results in full and typical function. PMID:12917869

  19. 77 FR 52346 - Hamden Slough National Wildlife Refuge, Becker County, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... began by publishing a notice of intent in the Federal Register (75 FR 7289) on February 18, 2010. For... Fish and Wildlife Service Hamden Slough National Wildlife Refuge, Becker County, MN AGENCY: Fish and... plan (CCP) and environmental assessment (EA) for the Hamden Slough National Wildlife Refuge...

  20. Analysis of Two Curricula: Englemann-Becker and New Nursery School. Final Report.

    ERIC Educational Resources Information Center

    Nalbandian, Myron K.

    Two curricula, Englemann-Becker and New Nursery School, were analyzed for effectiveness with Head Start children over a period of eight months, using the Slosson and Merrill-Palmer tests, a socialization scale and classroom observations. In congnitive development, there are no significant differences between the two curricula as used by teachers…

  1. AAMD-Becker Reading-Free Vocational Interest Inventory Manual [and Male and Female Inventories].

    ERIC Educational Resources Information Center

    Becker, Ralph L.

    The AAMD-Becker Reading-Free Vocational Interest Inventory is a non-reading vocational preference test for use with mentally retarded persons, particularly the educable mentally retarded at the high school level. Illustrations having occupational significance are presented in forced-choice format for selections. The instrument helps to identify…

  2. Dystrophin insufficiency causes a Becker muscular dystrophy-like phenotype in swine

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Duchenne muscular dystrophy (DMD) is caused by a dystrophin deficiency while Becker MD is caused by a dystrophin insufficiency or expression of a partially functional dystrophin protein. Deficiencies in existing mouse and dog models necessitate the development of a novel large animal model. Our pu...

  3. Pilot Peter Hoag and HL-10

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Air Force Major Peter Hoag stands in front of the HL-10 Lifting Body. Maj. Hoag joined the HL-10 program in 1969 and made his first glide flight on June 6, 1969. He made a total of 8 flights in the HL-10. They included the fastest lifting-body flight, which reached Mach 1.861 on Feb. 18, 1970. The HL-10 was one of five heavyweight lifting-body designs flown at NASA's Flight Research Center (FRC--later Dryden Flight Research Center), Edwards, California, from July 1966 to November 1975 to study and validate the concept of safely maneuvering and landing a low lift-over-drag vehicle designed for reentry from space. Northrop Corporation built the HL-10 and M2-F2, the first two of the fleet of 'heavy' lifting bodies flown by the NASA Flight Research Center. The contract for construction of the HL-10 and the M2-F2 was $1.8 million. 'HL' stands for horizontal landing, and '10' refers to the tenth design studied by engineers at NASA's Langley Research Center, Hampton, Va. After delivery to NASA in January 1966, the HL-10 made its first flight on Dec. 22, 1966, with research pilot Bruce Peterson in the cockpit. Although an XLR-11 rocket engine was installed in the vehicle, the first 11 drop flights from the B-52 launch aircraft were powerless glide flights to assess handling qualities, stability, and control. In the end, the HL-10 was judged to be the best handling of the three original heavy-weight lifting bodies (M2-F2/F3, HL-10, X-24A). The HL-10 was flown 37 times during the lifting body research program and logged the highest altitude and fastest speed in the Lifting Body program. On Feb. 18, 1970, Air Force test pilot Peter Hoag piloted the HL-10 to Mach 1.86 (1,228 mph). Nine days later, NASA pilot Bill Dana flew the vehicle to 90,030 feet, which became the highest altitude reached in the program. Some new and different lessons were learned through the successful flight testing of the HL-10. These lessons, when combined with information from it's sister ship, the M2

  4. Solution of Peter Winkler's Pizza Problem

    NASA Astrophysics Data System (ADS)

    Cibulka, Josef; Kynčl, Jan; Mészáros, Viola; Stolař, Rudolf; Valtr, Pavel

    Bob cuts a pizza into slices of not necessarily equal size and shares it with Alice by alternately taking turns. One slice is taken in each turn. The first turn is Alice's. She may choose any of the slices. In all other turns only those slices can be chosen that have a neighbor slice already eaten. We prove a conjecture of Peter Winkler by showing that Alice has a strategy for obtaining 4/9 of the pizza. This is best possible, that is, there is a cutting and a strategy for Bob to get 5/9 of the pizza. We also give a characterization of Alice's best possible gain depending on the number of slices. For a given cutting of the pizza, we describe a linear time algorithm that computes Alice's strategy gaining at least 4/9 of the pizza and another algorithm that computes the optimal strategy for both players in any possible position of the game in quadratic time. We distinguish two types of turns, shifts and jumps. We prove that Alice can gain 4/9, 7/16 and 1/3 of the pizza if she is allowed to make at most two jumps, at most one jump and no jump, respectively, and the three constants are the best possible.

  5. Writing with Teachers: A Conversation with Peter Elbow.

    ERIC Educational Resources Information Center

    Bartholomae, David

    1995-01-01

    Provides a complete text of David Bartholomae's speech on the debate with compositionist Peter Elbow regarding the pros and cons of teaching either academic discourse or personal writing modes to undergraduates. (HB)

  6. Life and Scientific Work of Peter Guthrie Tait

    NASA Astrophysics Data System (ADS)

    Gilston Knott, Cargill

    2015-04-01

    Preface; 1. Memoir - Peter Guthrie Tait; 2. Experimental work; 3. Mathematical work; 4. Quaternions; 5. Thomson and Tait, 'Tand T', or Thomson and Tait's natural philosophy; 6. Other books; 7. Addresses, reviews, and correspondence; 8. Popular scientific articles; Bibliography; Index.

  7. Peter Holland: a pioneer of occupational medicine.

    PubMed Central

    Murray, R

    1992-01-01

    The earliest recorded occupational health service in this country was that established in a cotton spinning factory at Quarry Bank Mill in Cheshire. The mill was built in 1784 by Samuel Greg and his partners. They employed local labour and also some parish apprentices. Happily, Samuel Greg was a good christian and, having created a modern factory and a model village with a church and a school, he was equally concerned for the physical welfare of his employees. Accordingly, he appointed a doctor to make pre-employment examinations of the apprentices and to visit regularly to deal with the health problems of a community of some 400 people. The man he chose was Peter Holland of Sandlebridge, who had served his medical apprenticeship under Dr Charles White of Manchester. The first record of the employment of a doctor was in 1796, but from 1804 to 1845 (doubtless in response to the early factory legislation) each visit of the doctor was entered in a day book with either an indication of fitness to work or details of the treatment required. The complete record consists of two hardback foolscap notebooks that provide a fascinating insight into the medical practice of the times when the industrial revolution was just getting under way. One of the more interesting features is the preservation of medical secrecy. Dr Holland made his comments on the case in shorthand and his instructions in longhand. By a fortunate coincidence the key to the shorthand was discovered and this has now been largely transcribed. Although much of the content of the diaries is the day by day practice of medicine at the time, there are many illuminating glimpses of the early practice of occupational medicine. Images PMID:1606023

  8. Peter Holland: a pioneer of occupational medicine.

    PubMed

    Murray, R

    1992-06-01

    The earliest recorded occupational health service in this country was that established in a cotton spinning factory at Quarry Bank Mill in Cheshire. The mill was built in 1784 by Samuel Greg and his partners. They employed local labour and also some parish apprentices. Happily, Samuel Greg was a good christian and, having created a modern factory and a model village with a church and a school, he was equally concerned for the physical welfare of his employees. Accordingly, he appointed a doctor to make pre-employment examinations of the apprentices and to visit regularly to deal with the health problems of a community of some 400 people. The man he chose was Peter Holland of Sandlebridge, who had served his medical apprenticeship under Dr Charles White of Manchester. The first record of the employment of a doctor was in 1796, but from 1804 to 1845 (doubtless in response to the early factory legislation) each visit of the doctor was entered in a day book with either an indication of fitness to work or details of the treatment required. The complete record consists of two hardback foolscap notebooks that provide a fascinating insight into the medical practice of the times when the industrial revolution was just getting under way. One of the more interesting features is the preservation of medical secrecy. Dr Holland made his comments on the case in shorthand and his instructions in longhand. By a fortunate coincidence the key to the shorthand was discovered and this has now been largely transcribed. Although much of the content of the diaries is the day by day practice of medicine at the time, there are many illuminating glimpses of the early practice of occupational medicine. PMID:1606023

  9. Paula Modersohn-Becker, the challenges of pregnancy and the weight of tradition

    PubMed Central

    2011-01-01

    Paula Modersohn-Becker, widely considered to have been one of the most important independent Expressionist painters of the early twentieth century, was thirty-one years old when she gave birth to her first child. Following the then-common practice of putting women to bed rest for two-four weeks after delivery, she died of massive pulmonary embolism when she was first allowed to stand, eighteen days after giving birth. Paula had foreseen her death at a young age and was apprehensive about her pregnancy, yet she painted herself as pregnant in her best known self-portrait, thus underlining the importance of the pregnancy in her life. In the light of knowledge available at the time, the authors present a brief discussion of the life and death of Paula Modersohn-Becker as a reflection on the potential dangers of blindly following conventional wisdom in the medical profession. PMID:21645346

  10. Ernest Becker and Stanley Milgram: Twentieth-century students of evil.

    PubMed

    Martin, Jack

    2016-02-01

    Both Stanley Milgram and Ernest Becker studied and theorized human evil and offered explanations for evil acts, such as those constituting the Holocaust. Yet the explanations offered by Becker and Milgram are strikingly different. In this essay, brief biographical records of their lives are provided. Differences in their research methods and theories are then examined and traced to relevant differences in their lives, education, and careers. Especially important in this regard were their personal experiences of evil and the scholarly practices and traditions of social scientific and humanities scholarship that characterized their graduate education and scholarly work. The final parts of the essay are devoted to a comparative and integrative analysis of their respective approaches to the question of evil, especially as manifest during the Holocaust, and a brief exegesis of their disciplinary commitments. PMID:26640976

  11. The clinical and molecular genetic approach to Duchenne and Becker muscular dystrophy: an updated protocol.

    PubMed Central

    van Essen, A J; Kneppers, A L; van der Hout, A H; Scheffer, H; Ginjaar, I B; ten Kate, L P; van Ommen, G J; Buys, C H; Bakker, E

    1997-01-01

    Detection of large rearrangements in the dystrophin gene in Duchenne and Becker muscular dystrophy is possible in about 65-70% of patients by Southern blotting or multiplex PCR. Subsequently, carrier detection is possible by assessing the intensity of relevant bands, but preferably by a non-quantitative test method. Detection of microlesions in Duchenne and Becker muscular dystrophy is currently under way. Single strand conformational analysis, heteroduplex analysis, and the protein truncation test are mostly used for this purpose. In this paper we review the available methods for detection of large and small mutations in patients and in carriers and propose a systematic approach for genetic analysis and genetic counselling of DMD and BMD families, including prenatal and preimplantation diagnosis. Images PMID:9350811

  12. Complementary and Alternative Medicine for Duchenne and Becker Muscular Dystrophies: Characteristics of Users and Caregivers

    PubMed Central

    Zhu, Yong; Romitti, Paul A.; Conway, Kristin M.; Andrews, Jennifer; Liu, Ke; Meaney, F. John; Street, Natalie; Puzhankara, Soman; Druschel, Charlotte M.; Matthews, Dennis J.

    2015-01-01

    BACKGROUND Complementary and alternative medicine is frequently used in the management of chronic pediatric diseases, but little is known about its use by those with Duchenne or Becker muscular dystrophy. METHODS Complementary and alternative medicine use by male patients with Duchenne or Becker muscular dystrophy and associations with characteristics of male patients and their caregivers were examined through interviews with 362 primary caregivers identified from the Muscular Dystrophy Surveillance, Tracking, and Research Network. RESULTS Overall, 272 of the 362 (75.1%) primary caregivers reported that they had used any complementary and alternative medicine for the oldest Muscular Dystrophy Surveillance, Tracking, and Research Network male in their family. The most commonly reported therapies were from the mind-body medicine domain (61.0%) followed by those from the biologically based practice (39.2%), manipulative and body-based practice (29.3%), and whole medical system (6.9%) domains. Aquatherapy, prayer and/or blessing, special diet, and massage were the most frequently used therapies. Compared with nonusers, male patients who used any therapy were more likely to have an early onset of symptoms and use a wheel chair; their caregivers were more likely to be non-Hispanic white. Among domains, associations were observed with caregiver education and family income (mind-body medicines [excluding prayer and/or blessing only] and whole medical systems) and Muscular Dystrophy Surveillance, Tracking, and Research Network site (biologically based practices and mind-body medicines [excluding prayer and/or blessing only]). CONCLUSIONS Complementary and alternative medicine use was common in the management of Duchenne and Becker muscular dystrophies among Muscular Dystrophy Surveillance, Tracking, and Research Network males. This widespread use suggests further study to evaluate the efficacy of integrating complementary and alternative medicine into treatment regimens for

  13. Validation of the modified Becker's split-window approach for retrieving land surface temperature from AVHRR

    NASA Astrophysics Data System (ADS)

    Quan, Weijun; Chen, Hongbin; Han, Xiuzhen; Ma, Zhiqiang

    2015-10-01

    To further verify the modified Becker's split-window approach for retrieving land surface temperature (LST) from long-term Advanced Very High Resolution Radiometer (AVHRR) data, a cross-validation and a radiance-based (R-based) validation are performed and examined in this paper. In the cross-validation, 3481 LST data pairs are extracted from the AVHRR LST product retrieved with the modified Becker's approach and compared with the Moderate Resolution Imaging Spectroradiometer (MODIS) LST product (MYD11A1) for the period 2002-2008, relative to the positions of 548 weather stations in China. The results show that in most cases, the AVHRR LST values are higher than the MYD11A1. When the AVHRR LSTs are adjusted with a linear regression, the values are close to the MYD11A1, showing a good linear relationship between the two datasets ( R 2 = 0.91). In the R-based validation, comparison is made between AVHRR LST retrieved from the modified Becker's approach and the inversed LST from the Moderate Resolution Transmittance Model (MODTRAN) consolidated with observed temperature and humidity profiles at four radiosonde stations. The results show that the retrieved AVHRR LST deviates from the MODTRAN inversed LST by-1.3 (-2.5) K when the total water vapor amount is less (larger) than 20 mm. This provides useful hints for further improvement of the LST retrieval algorithms' accuracy and consistency.

  14. Peter Elbow, Kenneth Burke, and the Idea of Magic.

    ERIC Educational Resources Information Center

    Briggs, John C.

    1991-01-01

    Asserts that the works of Peter Elbow and Kenneth Burke are valuable reference points because they problematize fundamental assumptions within the field of composition that pluralism and factional perspectives typically elide. Describes Elbow's rhetorical magic and shows how magic illuminates Burke's effort. Wonders whether Elbow and Burke…

  15. Edifying Violence: Peter Elbow and the Pedagogical Paradox.

    ERIC Educational Resources Information Center

    Briggs, John Channing

    1995-01-01

    Presents a critique of the common practice of writing instruction advocated by the well-known theorist Peter Elbow. Focuses on the paradox of pedagogical authority in writing classrooms. Reviews Elbow's writings in light of the problem of pedagogical authority. (HB)

  16. The Peter Shaw Award Acceptance Address: An Immigrant Sociologist

    ERIC Educational Resources Information Center

    Hollander, Paul

    2003-01-01

    This article presents the author's acceptance address for receiving the Peter Shaw award. In this address, the author, an immigrant sociologist, tells how this award helps to resolve questions and uncertainties he has as to the degree to which he can or should consider himself an American--about the extent to which he has become a part, a member…

  17. R. S. Peters and the Concept of Education

    ERIC Educational Resources Information Center

    Beckett, Kelvin Stewart

    2011-01-01

    In this essay Kelvin Beckett argues that Richard Peters's major work on education, "Ethics and Education," belongs on a short list of important texts we can all share. He argues this not because of the place it has in the history of philosophy of education, as important as that is, but because of the contribution it can still make to the future of…

  18. R. S. Peters' "The Justification of Education" Revisited

    ERIC Educational Resources Information Center

    Cuypers, Stefaan E.

    2012-01-01

    In his 1973 paper "The Justification of Education" R. S. Peters aspired to give a non-instrumental justification of education. Ever since, his so-called "transcendental argument" has been under attack and most critics conclude that it does not work. They have, however, thrown the baby away with the bathwater, when they furthermore concluded that…

  19. Peter Effect in the Preparation of Reading Teachers

    ERIC Educational Resources Information Center

    Binks-Cantrell, Emily; Washburn, Erin K.; Joshi, R. Malatesha; Hougen, Martha

    2012-01-01

    The Peter Effect (Applegate & Applegate, 2004) claimed that one cannot be expected to give what one does not possess. We applied this notion to reading teacher preparation and hypothesized that teacher educators who do not possess an understanding of basic language constructs would not prepare teacher candidates with an understanding of these…

  20. Team Leader: Tom Peters--TAP Information Services

    ERIC Educational Resources Information Center

    Library Journal, 2005

    2005-01-01

    Tom Peters packs 36 hours of work into the confines of a 24-hour day. Without breaking a sweat, he juggles multiple collaborative projects, which currently include an Illinois academic library shared storage facility; a multistate virtual reference and instruction service for blind and visually impaired individuals (InfoEyes); a virtual meeting…

  1. Advocating Science for All: An Interview with Peter J. Fensham

    ERIC Educational Resources Information Center

    Cardellini, Liberato

    2013-01-01

    After providing some glimpses of his private life, Peter Fensham, a leading figure of the prestigious Faculty of Education, Monash University (and now emeritus professor at Queensland University, Brisbane, Australia), gives some suggestions about the conditions that help students to learn meaningfully. He began his career in the field of physical…

  2. Marginal Experiments: Peter Brook and Stepping out Theatre Company

    ERIC Educational Resources Information Center

    Harpin, Anna

    2010-01-01

    This article juxtaposes the recent work of Peter Brook with a Bristol-based mental health service-user collective--Stepping Out Theatre Company. Informed by field-work with the company, this chapter explores the aesthetic and political relationship between professional, experimental theatre work and community-based performance practice. Drawing…

  3. My Journey with Peter: Moving Ideas that Matter

    ERIC Educational Resources Information Center

    Blyth, Dale A.

    2012-01-01

    Youth development lost a pioneer and a champion, Peter Benson, in October. Benson was a pioneer whose ideas mattered and a champion of approaches to research and its use in the community that has made a difference around the world. Benson's work, life, and spirit have helped transform people's understanding of young people, what it takes to…

  4. Portrait Face-Off: Gilbert Stuart vs. Peter Max

    ERIC Educational Resources Information Center

    Crumpecker, Cheryl

    2012-01-01

    When art classes are short and infrequent, it is always a challenge to meet required state and national standards. A unit comparing and contrasting Peter Max's Pop art portraits with the realistic style of Gilbert Stuart's presidential portraits provides an opportunity to address a huge number of these requirements. Focus can change with the age…

  5. Peters' Concept of "Education as Initiation": Communitarian or Individualist?

    ERIC Educational Resources Information Center

    Cotter, Richard

    2013-01-01

    A central element of Richard Peters' philosophy of education has been his analysis of "education as initiation". Understanding initiation is internally related to concepts of community and what it may mean to be a member. The concept of initiation assumes a mutually interdependent, dynamic relationship between the individual and community that…

  6. London in Space and Time: Peter Ackroyd and Will Self

    ERIC Educational Resources Information Center

    Green, Andrew

    2013-01-01

    This paper explores the treatment of London by two authors who are profoundly influenced by the concept of the power of place and the nature of urban space. The works of Peter Ackroyd, whose writings embody, according to Onega (1997, p. 208) "[a] yearning for mythical closure" where London is "a mystic centre of…

  7. Remembering Peter Drucker: inspiring the quality revolution in healthcare.

    PubMed

    Seeman, Neil; Brown, Adalsteinn D

    2006-01-01

    The authors review the late Peter Drucker's most significant writings, especially as they pertain to contemporary quality improvement principles in healthcare. In order to determine Drucker's most influential works, the authors conducted an empirical review of his impact by examining academic citations to his work and ideas. PMID:16548434

  8. Peter Drucker, Knowledge Work, and the Structure of Schools.

    ERIC Educational Resources Information Center

    Tucker, Marc S.

    1988-01-01

    Discusses Peter Drucker's recommendations in "The Age of Discontinuity" (1969) concerning the decline of manual work, the ascendancy of knowledge work, and the relationship between economic stability and an educated, productive work force. Applies Drucker's principles to the movement to restructure schools, which aims to make line workers…

  9. A Conversation with...Attila Pok & Peter Hanak.

    ERIC Educational Resources Information Center

    Cheney, Lynne V.

    1992-01-01

    Presents an interview with Hungarian historians Attila Pok and Peter Hanak. Explains the role of the Hungarian Academy of Sciences. Reveals how teachers and researchers functioned under Hungary's former socialist government. Discusses the shortage of educational resources in Hungary. Examines why intellectuals govern Hungary today. (SG)

  10. Lasiothyris luminosa (Razowski & Becker) (Lepidoptera: Tortricidae): a New Grapevine Pest in Northeastern Brazil.

    PubMed

    Costa-Lima, T C; Moreira, G R P; Gonçalves, G L; Specht, A

    2016-06-01

    The little-known Neotropical tortricid moth Lasiothyris luminosa (Razowski & Becker) is reported for the first time as a grapevine pest in northeastern Brazil. A diagnosis based on morphological characters including the genitalia is provided for both sexes, together with a preliminary description of economic damage caused by the larval stage on flowers and fruits. In addition, we sequenced a partial region of the cytochrome oxidase subunit I gene from specimens from the region and reconstructed phylogenetic relationships using representative lineages of closely related tortricids as terminals. PMID:26957083

  11. Rapid carrier and prenatal diagnosis of Duchenne and Becker muscular dystrophy

    SciTech Connect

    Roberts, R.G.; Cole, C.G.; Hart, K.A.; Bobrow, M.; Bentley, D.R. )

    1989-01-25

    Carrier and prenatal diagnosis of Duchenne and Becker muscular dystrophy (DMD and BMD) by DNA methods uses Southern blotting to detect either the informative segregation of restriction fragment length polymorphisms (RFLPs) or the absence of restriction fragments in affected males. Recently, the use of the polymerase chain reaction (PCR) for rapid detection of deletions in some affected males was reported eliminating the need for Southern blotting of 37% of all samples. This approach is not applicable, however, to non-deletion cases or for carrier diagnosis. The authors have used PCR for rapid analysis of intragenic RFLPs to permit both carrier and prenatal diagnosis in the majority of familial cases.

  12. Theories of Power, Poverty, and Law: In Commemoration of the Contributions of Peter Bachrach--The Challenge of Peter Bachrach

    ERIC Educational Resources Information Center

    Lukes, Steven

    2010-01-01

    Peter Bachrach had a remarkable impact on those who encountered him in person and on generations of readers. Judith Baer vividly captures, among other things, his inspiring, emboldening influence on his students and the sheer fun it was to be with him. My recollections are of exciting, forward moving, intense, and probing arguments, in private and…

  13. Peter Wilcox: A new purple-skin, yellow flesh fresh market potato cultivar

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Peter Wilcox is a new, medium-maturing, purple-skin, yellow-flesh potato cultivar for fresh market. Peter Wilcox also produces light-colored chips, although it is being released primarily as a fresh market potato because of its skin and flesh colors. Tubers of Peter Wilcox are attractive, smooth, wi...

  14. Von Tondern nach Gotha. Der Astronom Peter Andreas Hansen, 1795 - 1874.

    NASA Astrophysics Data System (ADS)

    Strumpf, M.; Pehlemann, E.; Wolfschmidt, G.

    This companion booklet to an exposition in honor of Peter Andreas Hansen's 200th birthday contains three papers. Contents: 1. Peter Andreas Hansen - Leben und Wirken in Gotha (M. Strumpf). 2. Peter Andreas Hansens wissenschaftliches Werk (E. Pehlemann). 3. Beobachtungsinstrumente der Sternwarte Gotha zur Zeit Hansens (G. Wolfschmidt).

  15. Molecular deletion patterns in Duchenne and Becker muscular dystrophy patients from KwaZulu Natal.

    PubMed

    Hallwirth Pillay, K D; Bill, P L A; Madurai, S; Mubaiwa, L; Rapiti, P

    2007-01-15

    There exists much phenotypic heterogeneity in Duchenne muscular dystrophy and its allelic variant, Becker muscular dystrophy. The molecular findings on 53 patients with Duchenne and 15 patients with Becker type muscular dystrophy in KwaZulu Natal, South Africa are reported. Multiplex PCR was performed using primers targeting 18 hot-spot exons throughout the dystrophin gene. Analysis of the multiplex PCR data revealed that 39/68 (57.0%) patients included in the study showed a deletion (33 DMD and 6 BMD patients). Twenty-five patients were Black, 4 were White and 10 were Indian. Using the Chamberlain and Beggs multiplex PCR assays, the region of the genome most frequently affected by a deletion includes exons 47-51. The distal region of the dystrophin gene was most frequently affected by the deletion in both Black and Indian patients. There were too few White patients for conclusions to be drawn concerning the most frequently affected part of the gene. Although the numbers are insufficient to determine whether ethnic differences are present, the Chamberlain and Beggs multiplex PCR assays detect deletions with the same frequency in South African DMD/BMD patients as that reported in the literature. PMID:17141273

  16. Selective loss of sarcolemmal nitric oxide synthase in Becker muscular dystrophy.

    PubMed

    Chao, D S; Gorospe, J R; Brenman, J E; Rafael, J A; Peters, M F; Froehner, S C; Hoffman, E P; Chamberlain, J S; Bredt, D S

    1996-08-01

    Becker muscular dystrophy is an X-linked disease due to mutations of the dystrophin gene. We now show that neuronal-type nitric oxide synthase (nNOS), an identified enzyme in the dystrophin complex, is uniquely absent from skeletal muscle plasma membrane in many human Becker patients and in mouse models of dystrophinopathy. An NH2-terminal domain of nNOS directly interacts with alpha 1-syntrophin but not with other proteins in the dystrophin complex analyzed. However, nNOS does not associate with alpha 1-syntrophin on the sarcolemma in transgenic mdx mice expressing truncated dystrophin proteins. This suggests a ternary interaction of nNOS, alpha 1-syntrophin, and the central domain of dystrophin in vivo, a conclusion supported by developmental studies in muscle. These data indicate that proper assembly of the dystrophin complex is dependent upon the structure of the central rodlike domain and have implications for the design of dystrophin-containing vectors for gene therapy. PMID:8760814

  17. Vera Peters and the curability of Hodgkin disease

    PubMed Central

    Cowan, D.H.

    2008-01-01

    The middle of the 20th century hailed the realization that patients with Hodgkin disease could be cured. Through the groundbreaking work of Vera Peters, patients with a localized form of the disorder, previously thought to be incurable, were shown to be cured by extended-field radiotherapy. This important observation, although not immediately accepted, opened the minds of physicians to take more positive investigative and therapeutic approaches. Peters also introduced and championed the concept of tumour staging in Hodgkin disease and the use of prognostic factors in clinical decision-making. This novel approach led to high cure rates with radiotherapy in localized disease and provided a scientific basis for the subsequent use of chemotherapy in disseminated disease, resulting in a very high cure rate in patients with all stages of Hodgkin disease. PMID:19008994

  18. A case of fascioscapulohumeral muscular dystrophy misdiagnosed as Becker's muscular dystrophy for 20 years.

    PubMed

    Ramos, Vesper Fe Marie Llaneza; Thaisetthawatkul, Pariwat

    2012-03-01

    A 60-year-old man diagnosed clinically with Becker's muscular dystrophy 20 years ago by another physician presented with gradually progressive proximal muscle weakness since teenage years. Family history revealed a strong paternal familial inheritance pattern of similar distribution of weakness-face, forearm flexion, knee extension and foot dorsiflexion. Work-ups revealed B12 deficiency and allele 1 deletion in fascioscapulohumeral muscular dystrophy (FSHD) DNA testing. FSHD is the third most common muscular dystrophy. Clinical diagnosis is made from the distinctive pattern of weakness, autosomal-dominant inheritance, and confirmed by genetic testing. This case strongly demonstrates the importance of a thorough and careful clinical evaluation even in a case with a long standing diagnosis. PMID:21795275

  19. Relatively low proportion of dystrophin gene deletions in Israeli Duchenne and Becker muscular dystrophy patients.

    PubMed

    Shomrat, R; Gluck, E; Legum, C; Shiloh, Y

    1994-02-15

    Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are allelic disorders caused by mutations in the X-linked dystrophin gene. The most common mutations in western populations are deletions that are spread non-randomly throughout the gene. Molecular analysis of the dystrophin gene structure by hybridization of the full length cDNA to Southern blots and by PCR in 62 unrelated Israeli male DMD/BMD patients showed deletions in 23 (37%). This proportion is significantly lower than that found in European and North American populations (55-65%). Seventy-eight percent of the deletions were confined to exons 44-52, half of these to exons 44-45, and the remaining 22% to exons 1 and 19. There was no correlation between the size of the deletion and the severity of the disease. All the deletions causing frameshift resulted in the DMD phenotypes. PMID:8160727

  20. Effect of Cellular Therapy in Progression of Becker's Muscular Dystrophy: A Case Study.

    PubMed

    Sharma, Alok; Sane, Hemangi; Gokulchandra, Nandini; Sharan, Rishabh; Paranjape, Amruta; Kulkarni, Pooja; Yadav, Jayanti; Badhe, Prerna

    2016-02-23

    Becker muscular dystrophy (BMD) is an inherited disorder due to deletions of the dystrophin gene that leads to muscle weakness. Effects of bone marrow mononuclear cell (BMMNC) transplantation in Muscular Dystrophy have shown to be safe and beneficial. We treated a 20-year-old male suffering from BMD with autologous BMMNC transplantation followed by multidisciplinary rehabilitation. He presented with muscle weakness and had difficulty in performing his activities. The BMMNCs were transplanted via intrathecal and intramuscular routes. The effects were measured on clinical and functional changes. Over 9 months, gradual improvement was noticed in muscle strength, respiratory functions and North Star Ambulatory Assessment Scale. Functional Independence Measure, Berg Balance Score, Brooke and Vignos Scale remained stable indicating halting of the progression. The case report suggests that cellular therapy combined with rehabilitation may have possibility of repairing and regenerating muscle fibers and decreasing the rate of progression of BMD. PMID:27054018

  1. Extensive Functional Evaluations to Monitor Aerobic Training in Becker Muscular Dystrophy: A Case Report

    PubMed Central

    Tramonti, Caterina; Rossi, Bruno; Chisari, Carmelo

    2016-01-01

    Low-intensity aerobic training seems to have positive effects on muscle strength, endurance and fatigue in Becker Muscular Dystrophy (BMD) patients. We describe the case of a 33-year old BMD man, who performed a four-week aerobic training. Extensive functional evaluations were executed to monitor the efficacy of the rehabilitative treatment. Results evidenced an increased force exertion and an improvement in muscle contraction during sustained exercise. An improvement of walk velocity, together with agility, endurance capacity and oxygen consumption during exercise was observed. Moreover, an enhanced metabolic efficiency was evidenced, as shown by reduced lactate blood levels after training. Interestingly, CK showed higher levels after the training protocol, revealing possible muscle damage. In conclusion, aerobic training may represent an effective method improving exercise performance, functional status and metabolic efficiency. Anyway, a careful functional assessment should be taken into account as a useful approach in the management of the disease’s rehabilitative treatment. PMID:27478558

  2. Relatively low proportion of dystrophin gene deletions in Israeili Duchenne and Becker muscular dystrophy patients

    SciTech Connect

    Shomrat, R.; Gluck, E.; Legum, C.; Shiloh, Y.

    1994-02-15

    Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are allelic disorders caused by mutations in the X-linked dystrophin gene. The most common mutations in western populations are deletions that are spread non-randomly throughout the gene. Molecular analysis of the dystrophin gene structure by hybridization of the full length cDNA to Southern blots and by PCR in 62 unrelated Israeli male DMD/BMD patients showed deletions in 23 (37%). This proportion is significantly lower than that found in European and North American populations (55-65%). Seventy-eight percent of the deletions were confined to exons 44-52, half of these exons 44-45, and the remaining 22% to exons 1 and 19. There was no correlation between the size of the deletion and the severity of the disease. All the deletions causing frameshift resulted in the DMD phenotypes. 43 refs., 1 fig., 1 tab.

  3. Dystrophin, utrophin and {beta}-dystroglycan expression in skeletal muscle from patients with Becker muscular dystrophy

    SciTech Connect

    Kawajiri, Masakazu; Mitsui, Takao; Kawai, Hisaomi

    1996-08-01

    The precise localization and semiquantitative correlation of dystrophin, utrophin and {beta}-dystroglycan expression on the sarcolemma of skeletal muscle cells obtained from patients with Becker muscular dystrophy (BMD) was studied using three types of double immunofluorescence. Staining intensity was measured using a confocal laser microscope. Each of these proteins was identified at the same locus on the sarcolemma. The staining intensities of dystrophin and utrophin were approximately reciprocal at sarcolemmal sites where dystrophin expression was obviously observed. The staining intensity of {beta}-dystroglycan was strong in areas where dystrophin staining was also strong and utrophin expression was weak. Quantitative analysis revealed that the staining intensity of {beta}-dystroglycan minus that of dystrophin approximated the staining intensity of utrophin, indicating that the sum of dystrophin and utrophin expression corresponds to that of {beta}-dystroglycan. These results suggest that utrophin may compensate for dystrophin deficiency found in BMD by binding to {beta}-dystroglycan. 35 refs., 3 figs., 1 tab.

  4. Prevalence of Duchenne and Becker Muscular Dystrophies in the United States

    PubMed Central

    Romitti, Paul A.; Zhu, Yong; Puzhankara, Soman; James, Katherine A.; Nabukera, Sarah K.; Zamba, Gideon K.D.; Ciafaloni, Emma; Cunniff, Christopher; Druschel, Charlotte M.; Mathews, Katherine D.; Matthews, Dennis J.; Meaney, F. John; Andrews, Jennifer G.; Caspers Conway, Kristin M.; Fox, Deborah J.; Street, Natalie; Adams, Melissa M.; Bolen, Julie

    2015-01-01

    OBJECTIVE To estimate prevalence of childhood-onset Duchenne and Becker muscular dystrophies (DBMD) in 6 sites in the United States by race/ethnicity and phenotype (Duchenne muscular dystrophy [DMD] or Becker muscular dystrophy [BMD]). METHODS In 2002, the Centers for Disease Control and Prevention established the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet) to conduct longitudinal, population-based surveillance and research of DBMD in the United States. Six sites conducted active, multiple-source case finding and record abstraction to identify MD STARnet cases born January 1982 to December 2011. We used cross-sectional analyses to estimate prevalence of DBMD per 10 000 boys, ages 5 to 9 years, for 4 quinquennia (1991–1995, 1996–2000, 2001–2005, and 2006–2010) and prevalence per 10 000 male individuals, ages 5 to 24 years, in 2010. Prevalence was also estimated by race/ethnicity and phenotype. RESULTS Overall, 649 cases resided in an MD STARnet site during $1 quinquennia. Prevalence estimates per 10 000 boys, ages 5 to 9 years, were 1.93, 2.05, 2.04, and 1.51, respectively, for 1991–1995, 1996–2000, 2001–2005, and 2006–2010. Prevalence tended to be higher for Hispanic individuals than non-Hispanic white or black individuals, and higher for DMD than BMD. In 2010, prevalence of DBMD was 1.38 per 10 000 male individuals, ages 5 to 24 years. CONCLUSIONS We present population-based prevalence estimates for DBMD in 6 US sites. Prevalence differed by race/ethnicity, suggesting potential cultural and socioeconomic influences in the diagnosis of DBMD. Prevalence also was higher for DMD than BMD. Continued longitudinal surveillance will permit us to examine racial/ethnic and socioeconomic differences in treatment and outcomes for MD STARnet cases. PMID:25687144

  5. A tribute to Peter A. Rona: A Russian Perspective

    NASA Astrophysics Data System (ADS)

    Sagalevich, Anatoly; Lutz, Richard A.

    2015-11-01

    In July 1985 Peter Rona led a cruise of the National Oceanic and Atmospheric Administration (NOAA) ship Researcher as part of the NOAA Vents Program and discovered, for the first time, black smokers, massive sulfide deposits and vent biota in the Atlantic Ocean. The site of the venting phenomena was the Trans-Atlantic Geotraverse (TAG) Hydrothermal Field on the east wall of the rift valley of the Mid-Atlantic Ridge at 26°08‧N; 44°50‧W (Rona, 1985; Rona et al., 1986). In 1986, Peter and an international research team carried out multidisciplnary investigations of both active and inactive hydrothermal zones of the TAG field using the R/V Atlantis and DSV Alvin, discovering two new species of shrimp (Rimicaris exoculata and Chorocaris chacei) (Williams and Rona, 1986) and a hexagonal-shaped form (Paleodictyon nodosum) thought to be extinct (Rona et al., 2009). In 1991 a Russian crew aboard the R/V Akademik Mstislav Keldysh, with two deep-diving, human-occupied submersibles (Mir-1 and Mir-2) (Fig. 1), had the honor of having Peter Rona and a Canadian IMAX film crew from the Stephen Low Company on board to visit the TAG hydrothermal vent field. This was the first of many deep-sea interactions between Russian deep-sea scientists and their colleagues from both the U.S. and Canada. This expedition to the TAG site was part of a major Russian undersea program aimed at exploring extreme deep-sea environments; between 1988 and 2005, the Mir submersibles visited hydrothermal vents and cold seep areas in 20 deep-sea regions throughout the world's oceans (Sagalevich, 2002). Images of several of these areas (the TAG, Snake Pit, Lost City and 9°50‧N vent fields) were obtained using an IMAX camera system emplaced for the first time within the spheres of the Mir submersibles and DSV Alvin in conjunction with the filming of science documentaries (e.g., "Volcanoes of the Deep Sea") produced by the Stephen Low Company in conjunction with Emory Kristof of National Geographic and

  6. Peter Bergmann:The Education of a Physicist

    NASA Astrophysics Data System (ADS)

    Halpern, Paul

    2005-12-01

    I explore the early life and contributions of Peter Bergmann (1915 2002), focusing on his family background, education, and ideas. I examine how Bergmann’s formative years were shaped by the outspoken influence of his mother, a leading educational reformer; the distinguished reputation of his father, a renowned materials chemist; and his cherished hope of working with Albert Einstein (1879 1955), to whom he eventually became an assistant. Inspired by these and other notable thinkers, Bergmann became an exemplary organizer, educator, and mentor in the fields of general relativity and quantum gravity.

  7. The lack of the Celf2a splicing factor converts a Duchenne genotype into a Becker phenotype

    PubMed Central

    Martone, J.; Briganti, F.; Legnini, I.; Morlando, M.; Picillo, E.; Sthandier, O.; Politano, L.; Bozzoni, I.

    2016-01-01

    Substitutions, deletions and duplications in the dystrophin gene lead to either the severe Duchenne muscular dystrophy (DMD) or mild Becker muscular dystrophy depending on whether out-of-frame or in-frame transcripts are produced. We identified a DMD case (GSΔ44) where the correlation between genotype and phenotype is not respected, even if carrying a typical Duchenne mutation (exon 44 deletion) a Becker-like phenotype was observed. Here we report that in this patient, partial restoration of an in-frame transcript occurs by natural skipping of exon 45 and that this is due to the lack of Celf2a, a splicing factor that interacts with exon 45 in the dystrophin pre-mRNA. Several experiments are presented that demonstrate the central role of Celf2a in controlling exon 45 splicing; our data point to this factor as a potential target for the improvement of those DMD therapeutic treatments, which requires exon 45 skipping. PMID:26796035

  8. John P. Peters and the committee of 430 physicians.

    PubMed

    Lundberg, George D

    2002-01-01

    John Peters and his committee had a few basic goals. One was that local, state, and federal governments needed to provide money to construct facilities, support medical research and education, and care for the poor. And they wanted experts to call the shots. Over time, Peters and the committee got what they wanted for the most part: Hill-Burton money for building the hospitals, the rise of the National Institutes of Health, Medicare, Medicaid, a Veterans Administration system, and new and expanded medical schools. The experts calling the shots included David Kessler at the Food and Drug Administration and Surgeon General C. Everett Koop. In the halcyon days of American health system reform, back in 1993, Yale's Paul Beeson wrote about the Committee of 430 Physicians and its goals in the Pharos of Alpha Omega Alpha. Beeson was optimistic and he quoted from my 1991 JAMA health system reform editorial as a sharp contrast to what Fishbein had written - although coincidentally, we both quote Lincoln. My editorial began, "'with malice toward none, with charity for all...' so spoke Abraham Lincoln in his second inaugural address recognizing that he had no political consensus regarding either the constitutionality of states seceding or the morality of slavery being abolished. Nonetheless, he knew what was right and was able, through persuasive, often inspiring rhetoric, to conclude a bloody and decisive Civil War and constitute the foundation for this great republic.... Yet access to basic medical care for all of our inhabitants is still not a reality in this country. There are many reasons for this, not the least of which is a long-standing, systematic, institutionalized racial discrimination.... An aura of inevitablitiy is upon us. It is not acceptable morally, ethically, or economically for so many of our people to be medically uninsured or seriously underinsured. We can solve this problem. We have the knowledge and the resources, the skills, the time, and the moral

  9. Vision and Elusiveness in Philosophy of Education: R. S. Peters on the Legacy of Michael Oakeshott

    ERIC Educational Resources Information Center

    Williams, Kevin

    2009-01-01

    Despite his elusiveness on important issues, there is much in Michael Oakeshott's educational vision that Richard Peters quite rightly wishes to endorse. The main aim of this essay is, however, to consider Peters' justifiable critique of three features of Oakeshott's work. These are (1) the rigidity of his distinction between vocational and…

  10. Reflections on Peters' View of the Nature and Purpose of Work in Philosophy of Education

    ERIC Educational Resources Information Center

    Aspin, D. N.

    2013-01-01

    In this article I describe the analytic approach adopted by Peters, his colleagues and followers of the "London line" in the 1960s and 1970s and argue that, even in those times, other approaches to philosophy of education were being valued and practised. I show that Peters and his colleagues later became aware of the need for philosophy of…

  11. The Future of the Digital Library: An Interview with Tom Peters

    ERIC Educational Resources Information Center

    Morrison, James L.; Peters, Tom

    2005-01-01

    This article presents an interview with Tom Peters, an academic librarian and founder of TAP Information Services, a firm that provides consulting services to libraries and other organizations in the information industry. Peters also serves as a consultant to LibraryCity, an ambitious project that seeks to make thousands of e-books in easy-to-use…

  12. The "Physically Educated" Person: Physical Education in the Philosophy of Reid, Peters and Aristotle

    ERIC Educational Resources Information Center

    MacAllister, James

    2013-01-01

    This article will derive a definition and account of the physically educated person, through an examination of the philosophy of Andrew Reid, Richard Peters and Aristotle. Initially, Reid's interpretation of Peters' views about the educational significance of practical knowledge (and physical education) will be considered. While it will…

  13. Ripples from a Passing Ship: Memories; and a Legacy of Richard Peters

    ERIC Educational Resources Information Center

    Harris, Kevin

    2013-01-01

    This paper outlines aspects and dimensions of my "relationship" with Richard Peters from 1966 onward. The underlying suggestion is that, while Peters' contribution to philosophy of education was undeniably of major proportions, both that contribution and his legacy are institutional rather than substantive. (Contains 15 notes.)

  14. Otto Peters on Distance Education: The Industrialization of Teaching and Learning. Routledge Studies in Distance Education.

    ERIC Educational Resources Information Center

    Keegan, Desmond, Ed.

    This book contains new and previously published translations of 11 essays and articles about the industrialization of teaching and learning in distance education that were originally published in German by Otto Peters between 1965 and 1993. A "Preface" (Desmond Keegan) and an introduction placing Peters' writings in their historical context begin…

  15. A phase 1/2a follistatin gene therapy trial for becker muscular dystrophy.

    PubMed

    Mendell, Jerry R; Sahenk, Zarife; Malik, Vinod; Gomez, Ana M; Flanigan, Kevin M; Lowes, Linda P; Alfano, Lindsay N; Berry, Katherine; Meadows, Eric; Lewis, Sarah; Braun, Lyndsey; Shontz, Kim; Rouhana, Maria; Clark, Kelly Reed; Rosales, Xiomara Q; Al-Zaidy, Samiah; Govoni, Alessandra; Rodino-Klapac, Louise R; Hogan, Mark J; Kaspar, Brian K

    2015-01-01

    Becker muscular dystrophy (BMD) is a variant of dystrophin deficiency resulting from DMD gene mutations. Phenotype is variable with loss of ambulation in late teenage or late mid-life years. There is currently no treatment for this condition. In this BMD proof-of-principle clinical trial, a potent myostatin antagonist, follistatin (FS), was used to inhibit the myostatin pathway. Extensive preclinical studies, using adeno-associated virus (AAV) to deliver follistatin, demonstrated an increase in strength. For this trial, we used the alternatively spliced FS344 to avoid potential binding to off target sites. AAV1.CMV.FS344 was delivered to six BMD patients by direct bilateral intramuscular quadriceps injections. Cohort 1 included three subjects receiving 3 × 10(11) vg/kg/leg. The distance walked on the 6MWT was the primary outcome measure. Patients 01 and 02 improved 58 meters (m) and 125 m, respectively. Patient 03 showed no change. In Cohort 2, Patients 05 and 06 received 6 × 10(11) vg/kg/leg with improved 6MWT by 108 m and 29 m, whereas, Patient 04 showed no improvement. No adverse effects were encountered. Histological changes corroborated benefit showing reduced endomysial fibrosis, reduced central nucleation, more normal fiber size distribution with muscle hypertrophy, especially at high dose. The results are encouraging for treatment of dystrophin-deficient muscle diseases. PMID:25322757

  16. Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy

    PubMed Central

    Rodríguez-Cruz, Maricela; Sanchez, Raúl; Escobar, Rosa E.; Cruz-Guzmán, Oriana del Rocío; López-Alarcón, Mardia; Bernabe García, Mariela; Coral-Vázquez, Ramón; Matute, Guadalupe; Velázquez Wong, Ana Claudia

    2015-01-01

    Aim. Our aim was (1) to determine the frequency of insulin resistance (IR) in patients with Duchenne/Becker muscular dystrophy (DMD/BMD), (2) to identify deleted exons of DMD gene associated with obesity and IR, and (3) to explore some likely molecular mechanisms leading to IR. Materials and Methods. In 66 patients with DMD/BMD without corticosteroids treatment, IR, obesity, and body fat mass were evaluated. Molecules involved in glucose metabolism were analyzed in muscle biopsies. Results show that 18.3%, 22.7%, and 68% were underweight, overweight, or obese, and with high adiposity, respectively; 48.5% and 36.4% presented hyperinsulinemia and IR, respectively. Underweight patients (27.3%) exhibited hyperinsulinemia and IR. Carriers of deletions in exons 45 (OR = 9.32; 95% CI = 1.16–74.69) and 50 (OR = 8.73; 95% CI = 1.17–65.10) from DMD gene presented higher risk for IR than noncarriers. We observed a greater staining of cytoplasmic aggregates for GLUT4 in muscle biopsies than healthy muscle tissue. Conclusion. Obesity, hyperinsulinemia, and IR were observed in DMD/BMD patients and are independent of corticosteroids treatment. Carriers of deletion in exons 45 or 50 from DMD gene are at risk for developing IR. It is suggested that alteration in GLUT4 in muscle fibers from DMD patients could be involved in IR. PMID:26089900

  17. Dystrophin and the two related genetic diseases, Duchenne and Becker muscular dystrophies

    PubMed Central

    Rumeur, Elisabeth Le

    2015-01-01

    Mutations of the dystrophin DMD gene, essentially deletions of one or several exons, are the cause of two devastating and to date incurable diseases, Duchenne (DMD) and Becker (BMD) muscular dystrophies. Depending upon the preservation or not of the reading frame, dystrophin is completely absent in DMD, or present in either a mutated or a truncated form in BMD. DMD is a severe disease which leads to a premature death of the patients. Therapy approaches are evolving with the aim to transform the severe DMD in the BMD form of the disease by restoring the expression of a mutated or truncated dystrophin. These therapies are based on the assumption that BMD is a mild disease. However, this is not completely true as BMD patients are more or less severely affected and no molecular basis of this heterogeneity of the BMD form of the disease is yet understood. The aim of this review is to report for the correlation between dystrophin structures in BMD deletions in view of this heterogeneity and to emphasize that examining BMD patients in details is highly relevant to anticipate for DMD therapy effects. PMID:26295289

  18. Dystrophin analysis using a panel of anti-dystrophin antibodies in Duchenne and Becker muscular dystrophy.

    PubMed

    Muntoni, F; Mateddu, A; Cianchetti, C; Marrosu, M G; Clerk, A; Cau, M; Congiu, R; Cao, A; Melis, M A

    1993-01-01

    Dystrophin, the protein product of the Duchenne muscular dystrophy (DMD) gene, was studied in 19 patients with Xp21 disorders and in 25 individuals with non-Xp21 muscular dystrophy. Antibodies raised to seven different regions spanning most of the protein were used for immunocytochemistry. In all patients specific dystrophin staining anomalies were detected and correlated with clinical severity and also gene deletion. In patients with Becker muscular dystrophy (BMD) the anomalies detected ranged from inter- and intra-fibre variation in labelling intensity with the same antibody or several antibodies to general reduction in staining and discontinuous staining. In vitro evidence of abnormal dystrophin breakdown was observed reanalysing the muscle of patients, with BMD and not that of non-Xp21 dystrophies, after it has been stored for several months. A number of patients with DMD showed some staining but this did not represent a diagnostic problem. Based on the data presented, it was concluded that immunocytochemistry is a powerful technique in the prognostic diagnosis of Xp21 muscular dystrophies. PMID:8429320

  19. A molecular survey of Israeli Duchenne and Becker muscular dystrophy patients.

    PubMed

    Legum, C; Shomrat, R; Glassner, M; Shiloh, Y

    1994-01-01

    Duchenne (DMD) and Becker (BMD) muscular dystrophy are allelic X-linked recessive diseases caused by a mutation in the dystrophin gene located on the short arm of chromosome X (Xp21). The dystrophin gene is the largest gene known in humans, extending over 2300 kb and containing more than 70 exons coding for a 420 KD protein comprising 3685 amino acids. The gene is highly unstable, with a high percentage of deletions and rearrangements. A third of dystrophin mutations are new mutations. The frequency of DMD is 1:3500 liveborn males, and that of BMD 1:10000. These dystrophies are severe, progressive, and lethal. BMD/DMD patients and 2/3 of female carriers have high levels of creatine phosphokinase (CK). During the past 5 years, 169 families with patients affected by progressive muscular dystrophy were examined and counselled. We were able to exclude the diagnosis of DMD/BMD in 49 families on the basis of clinical symptoms and signs, normal dystrophin on biopsy (11 families) and/or the absence of linkage to chromosome X by analysis of RFLP derived haplotypes. Molecular analysis was performed on 111 DMD/BMD families (five BMD and 106 DMD) with 81 available probands. This study resulted in the establishment in Israel of an integrated diagnostic protocol for DMD/BMD, employing genetic, biochemical and molecular techniques. Molecular analysis provided most of the families with new and essential information. PMID:7858172

  20. Therapeutic Potential of Proteasome Inhibition in Duchenne and Becker Muscular Dystrophies

    PubMed Central

    Gazzerro, Elisabetta; Assereto, Stefania; Bonetto, Andrea; Sotgia, Federica; Scarfì, Sonia; Pistorio, Angela; Bonuccelli, Gloria; Cilli, Michele; Bruno, Claudio; Zara, Federico; Lisanti, Michael P.; Minetti, Carlo

    2010-01-01

    Duchenne muscular dystrophy (DMD) and its milder allelic variant, Becker muscular dystrophy (BMD), result from mutations of the dystrophin gene and lead to progressive muscle deterioration. Enhanced activation of proteasomal degradation underlies critical steps in the pathogenesis of the DMD/BMD dystrophic process. Previously, we demonstrated that treatment with the proteasome inhibitor MG-132 rescues the cell membrane localization of dystrophin and the dystrophin glycoprotein complex in mdx mice, a natural genetic mouse model of DMD. The current work aims to thoroughly define the therapeutic potential in dystrophinopathies of Velcade, a drug that selectively blocks the ubiquitin-proteasome pathway. Velcade is particularly intriguing since it has been approved for the treatment of multiple myeloma. Therefore, its side effects in humans have been explored. Velcade effects were analyzed through two independent methodological approaches. First, we administered the drug systemically in mdx mice over a 2-week period. In this system, Velcade restores the membrane expression of dystrophin and dystrophin glycoprotein complex members and improves the dystrophic phenotype. In a second approach, we treated with the compound explants from muscle biopsies of DMD or BMD patients. We show that the inhibition of the proteasome pathway up-regulates dystrophin, α-sarcoglycan, and β-dystroglycan protein levels in explants from BMD patients, whereas it increases the proteins of the dystrophin glycoprotein complex in DMD cases. PMID:20304949

  1. Functional changes in Becker muscular dystrophy: implications for clinical trials in dystrophinopathies.

    PubMed

    Bello, Luca; Campadello, Paola; Barp, Andrea; Fanin, Marina; Semplicini, Claudio; Sorarù, Gianni; Caumo, Luca; Calore, Chiara; Angelini, Corrado; Pegoraro, Elena

    2016-01-01

    We performed a 1-year longitudinal study of Six Minute Walk Test (6MWT), North Star Ambulatory Assessment (NSAA), and timed function tests in Becker muscular dystrophy (BMD). Skeletal muscle dystrophin was quantified by immunoblot. We grouped deletions ending on exon 45 ("del 45-x", n = 28) or 51 ("del x-51", n = 10); isolated exon 48 deletion ("del 48", n = 10); and other mutations (n = 21). Only patients in the "del 45-x" or "other" groups became non-ambulatory (n = 5, log-rank p = n.s.) or unable to run (n = 22, p < 0.001). All measures correlated positively with dystrophin quantity and negatively with age, and were significantly more impaired in the "del 45-x" and "other" groups. After one year, NSAA score decreased significantly (-0.9 ± 1.6, p < 0.001); in the "del 45-x" group, both NSAA (-1.3 ± 1.7, p = 0.001) and 6MWT (-12 ± 31 m, p = 0.059) decreased. We conclude that patients with "del x-51" or "del 48" mutations have mild or asymptomatic BMD, while "del 45-x" mutations cause comparatively severe weakness, and functional deterioration in 1 year. Furthermore, exon 51 skipping could be more effective than exon 45 skipping in Duchenne muscular dystrophy. PMID:27582364

  2. Non‐invasive prenatal diagnosis of Duchenne and Becker muscular dystrophies by relative haplotype dosage†

    PubMed Central

    Court, Samantha; Cleary, Siobhan; Clokie, Samuel; Hewitt, Julie; Williams, Denise; Cole, Trevor; MacDonald, Fiona; Griffiths, Mike; Allen, Stephanie

    2016-01-01

    Abstract Objective Development of an accurate and affordable test for the non‐invasive prenatal diagnosis of Duchenne and Becker muscular dystrophies (DMD/BMD) to implement in clinical practice. Method Cell‐free DNA was extracted from maternal blood and prepared for massively parallel sequencing on an Illumina MiSeq by targeted capture enrichment of single nucleotide polymorphisms (SNPs) across the dystrophin gene on chromosome X. Sequencing data were analysed by relative haplotype dosage. Results Seven healthy pregnant donors and two pregnant DMD carriers all bearing a male fetus were recruited through the non‐invasive prenatal diagnosis for single gene disorders study. Non‐invasive prenatal diagnosis testing was conducted by relative haplotype dosage analysis for X‐linked disorders where the genomic DNA from the chorionic villus sampling (for healthy pregnant donors) or from the proband (for pregnant DMD carriers) was used to identify the reference haplotype. Results for all patients showed a test accuracy of 100%, when the calculated fetal fraction was >4% and correlated with known outcomes. A recombination event was also detected in a DMD patient. Conclusion Our new test for NIPD of DMD/BMD has been shown to be accurate and reliable during initial stages of validation. It is also feasible for implementation into clinical service. © 2016 The Authors. Prenatal Diagnosis published by John Wiley & Sons, Ltd. PMID:26824862

  3. The Baade-Becker-Wesselink technique and the fundamental astrophysical parameters of Cepheids

    NASA Astrophysics Data System (ADS)

    Rastorguev, Alexey S.; Dambis, Andrey K.; Zabolotskikh, Marina V.; Berdnikov, Leonid N.; Gorynya, Natalia A.

    2013-02-01

    The Baade-Becker-Wesselink (BBW) method remains one of most often used tools to derive a full set of Cepheid astrophysical parameters. The surface brightness version of the BBW technique was preferentially used during the past few decades to calculate Cepheid radii and to improve period-luminosity-colour relations. Its implementation requires a priori knowledge of Cepheid reddening values. We propose a new version of the BBW technique, which allows one to independently determine the colour excess and the intrinsic colour of a radially pulsating star, in addition to its radius, luminosity and distance. The new technique is a generalization of the Balona light curve-modelling approach. The method also allows calibration of the function F(CI0) = BC(CI0) + 10 log [T eff (CI0)] for the class of pulsating stars considered. We apply this technique to a number of classical Cepheids with very accurate light and radial-velocity curves. The new technique can also be applied to other pulsating variables, e.g., RR Lyrae stars. We also discuss the possible dependence of the projection factor on the pulsation phase.

  4. [Specific features of Becker Muscular Dystrophy patients and female carriers of Duchenne Muscular Dystrophy].

    PubMed

    Magot, A; Mercier, S; Péréon, Y

    2015-12-01

    Becker muscular dystrophy (BMD) was first described in 1955 and linked to the DMD gene in 1987. Compared to Duchenne muscular dystrophy (DMD), clinical onset of BMD usually occurs after the age of 12 and wheelchair is required after the age of 16. BMD is characterized by generalized weakness first affecting limb girdle muscles, hypertrophy of the calves and cardiomyopathy in males. Some patients have only mild symptoms such as cramps or elevated serum creatine kinases (SCK) throughout all their lives. SCK levels are usually elevated. Muscle biopsy (immunohistochemistry or immunoblotting) shows a dystrophic pattern with abnormal dystrophin staining. Diagnosis is confirmed by DMD gene sequencing. Deletions or duplications of one or several exons are identified in the majority of cases. A multidisciplinary approach is recommended for the care management of these patients with a particular attention to the cardiomyopathy, which is typically responsible for death but can be prevented by specific treatment. X-linked dilated cardiomyopathies linked to DMD gene are a phenotypic continuum of BMD. Some female carriers of DMD mutations exhibit clinical symptoms of variable severity, often milder and beginning later than in males. The cardiomyopathy is the most frequent feature that should be especially monitored in these patients. Genetic counselling should be systematically proposed. PMID:26773584

  5. Fluorescent multiplex linkage analysis and carrier detection for Duchenne/Becker muscular dystrophy

    SciTech Connect

    Schwartz, L.S.; Hoffman, E.P. ); Tarleton, J. ); Popovich, B. ); Seltzer, W.K. )

    1992-10-01

    The authors have developed a fast and accurate PCR-based linkage and carrier detection protocol for families of Duchenne muscular dystrophy (DMD)/Becker muscular dystrophy (BMD) patients with or without detectable deletions of the dystrophin gene, using fluorescent PCR products analyzed on an automated sequencer. When a deletion is found in the affected male DMD/BMD patient by standard multiplex PCR, fluorescently labeled primers specific for the deleted and nondeleted exon(s) are used to amplify the DNA of at-risk female relatives by using multiplex PCR at low cycle number (20 cycles). The products are then quantitatively analyzed on an automatic sequencer to determine whether they are heterozygous for the deletion and thus are carriers. As a confirmation of the deletion data, and in cases in which a deletion is not found in the proband, fluorescent multiplex PCR linkage is done by using four previously described polymorphic dinucleotide sequences. The four (CA)[sub n] repeats are located throughout the dystrophin gene, making the analysis highly informative and accurate. The authors present the successful application of this protocol in families who proved refractory to more traditional analyses. 22 refs., 3 figs.

  6. STS-81 Mission Specialist Peter Wisoff suits up

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-81 Mission Specialist Peter J. K. 'Jeff' Wisoff prepares for the fifth Shuttle- Mir docking as he waits in the Operations and Checkout (O&C) Building for the operation to fit him into his launch/entry suit to be completed. He conducted a spacewalk on his on his first Shuttle mission, STS- 57 and holds a doctorate degree in applied physics with an emphasis on lasers and semiconductor materials. He and five crew members will shortly depart the O&C and head for Launch Pad 39B, where the Space Shuttle Atlantis will lift off during a 7-minute window that opens at 4:27 a.m. EST, January 12.

  7. [Peter of Abano, the 'Conciliator' between magic and science].

    PubMed

    Federici Vescovini, Graziella

    2008-01-01

    Peter of Abano is a personage belonging to history as well as to legend. In this analysis his historical physiognomy of scientist and physician is reconstructed on the basis of a better knowledge of his works in medicine and astronomy (now edited), a discipline, the latest one, in which he excelled in Medieval scientific context (The Lucidator dubitabilium astronomiae (astrologiae) can be read in the critical edition by G. Federici Vescovini, Padova, Esedra, 1992). He opposed extreme position in all fields, by styling himself 'Conciliator' of opposed tendencies. He often reconfirmed a rational concept of medicine and astronomy, which dispelled any demoniac and magic features, against the fanciful legend elaborated during the following centuries. PMID:19831246

  8. Mutations in the CLCN1 gene leading to myotonia congenita Thomsen and generalized myotonia Becker

    SciTech Connect

    Koch, M.C.; Meyer-Kline, C.; Otto, M.

    1994-09-01

    Autosomal dominant inherited myotonia congenita Thomsen (MC) and autosomal recessive generalized myotonia Becker (GM) are non-dystropic muscle disorders in which the symptom myotonia is based on an increased excitability of the muscle fiber membrane due to a reduced sarcolemmal chloride conductance. Affected individuals exhibit myotonic muscle stiffness in all skeletal muscles and a transient muscle weakness is particularly pronounced in the arms and hands of probands with the disorder GM. Recently we have shown linkage of the disorders MC and GM to the gene CLCN1 coding for the skeletal muscle chloride channel on chromosome 7 in German families. In addition we presented data supporting the hypothesis that GM is a genetically homogeneous disorder. Data are presented about an extended screen for mutations in the CLCN1 gene for our MC and GM population. We identified mainly missense mutations leading to altered amino acid codons. The previously described F413C mutation is by far the most common mutation for GM and is found in one family only (P480L, G482R, R496S). In addition we found 5{prime} donor and 3{prime} acceptor splice site mutations at various intron-exon boundaries, as well as a deletion mutation of 14 bp in exon 13. This deletion mutation is the second most common mutation in the GM population with a frequency of 8%. So far we have not determined sites of predominance of mutations in the CLCN1 gene, which could give us more insight into the regions critical for the function of the channel and the fact that the mutations in the gene may lead to dominant and recessive inheritance.

  9. Functional changes in Becker muscular dystrophy: implications for clinical trials in dystrophinopathies

    PubMed Central

    Bello, Luca; Campadello, Paola; Barp, Andrea; Fanin, Marina; Semplicini, Claudio; Sorarù, Gianni; Caumo, Luca; Calore, Chiara; Angelini, Corrado; Pegoraro, Elena

    2016-01-01

    We performed a 1-year longitudinal study of Six Minute Walk Test (6MWT), North Star Ambulatory Assessment (NSAA), and timed function tests in Becker muscular dystrophy (BMD). Skeletal muscle dystrophin was quantified by immunoblot. We grouped deletions ending on exon 45 (“del 45-x”, n = 28) or 51 (“del x-51”, n = 10); isolated exon 48 deletion (“del 48”, n = 10); and other mutations (n = 21). Only patients in the “del 45-x” or “other” groups became non-ambulatory (n = 5, log-rank p = n.s.) or unable to run (n = 22, p < 0.001). All measures correlated positively with dystrophin quantity and negatively with age, and were significantly more impaired in the “del 45-x” and “other” groups. After one year, NSAA score decreased significantly (−0.9 ± 1.6, p < 0.001); in the “del 45-x” group, both NSAA (−1.3 ± 1.7, p = 0.001) and 6MWT (−12 ± 31 m, p = 0.059) decreased. We conclude that patients with “del x-51” or “del 48” mutations have mild or asymptomatic BMD, while “del 45-x” mutations cause comparatively severe weakness, and functional deterioration in 1 year. Furthermore, exon 51 skipping could be more effective than exon 45 skipping in Duchenne muscular dystrophy. PMID:27582364

  10. Sodium nitrate alleviates functional muscle ischaemia in patients with Becker muscular dystrophy.

    PubMed

    Nelson, Michael D; Rosenberry, Ryan; Barresi, Rita; Tsimerinov, Evgeny I; Rader, Florian; Tang, Xiu; Mason, O'Neil; Schwartz, Avery; Stabler, Thomas; Shidban, Sarah; Mobaligh, Neigena; Hogan, Shomari; Elashoff, Robert; Allen, Jason D; Victor, Ronald G

    2015-12-01

    Becker muscular dystrophy (BMD) is a progressive X-linked muscle wasting disease for which there is no treatment. BMD is caused by in-frame mutations in the gene encoding dystrophin, a structural cytoskeletal protein that also targets other proteins to the sarcolemma. Among these is neuronal nitric oxide synthase mu (nNOSμ), which requires specific spectrin-like repeats (SR16/17) in dystrophin's rod domain and the adaptor protein α-syntrophin for sarcolemmal targeting. When healthy skeletal muscle is exercised, sarcolemmal nNOSμ-derived nitric oxide (NO) attenuates α-adrenergic vasoconstriction, thus optimizing perfusion. In the mdx mouse model of dystrophinopathy, this protective mechanism (functional sympatholysis) is defective, resulting in functional muscle ischaemia. Treatment with a NO-donating non-steroidal anti-inflammatory drug (NSAID) alleviates this ischaemia and improves the murine dystrophic phenotype. In the present study, we report that, in 13 men with BMD, sympatholysis is defective mainly in patients whose mutations disrupt sarcolemmal targeting of nNOSμ, with the vasoconstrictor response measured as a decrease in muscle oxygenation (near infrared spectroscopy) to reflex sympathetic activation. Then, in a single-arm, open-label trial in 11 BMD patients and a double-blind, placebo-controlled cross-over trial in six patients, we show that acute treatment with oral sodium nitrate, an inorganic NO donor without a NSIAD moiety, restores sympatholysis and improves post-exercise hyperaemia (Doppler ultrasound). By contrast, sodium nitrate improves neither sympatholysis, nor hyperaemia in healthy controls. Thus, a simple NO donor recapitulates the vasoregulatory actions of sarcolemmal nNOS in BMD patients, and constitutes a putative novel therapy for this disease. PMID:26437761

  11. 1988 Horton Medal presented to Peter S. Eagleson

    NASA Astrophysics Data System (ADS)

    Rodriguez-Iturbe, Ignacio; Eagleson, Peter S.

    It is indeed a great honor for me, and also a great pleasure, to present to you the 1988 recipient of the Robert E. Horton Medal, Peter S. Eagleson. Shortly after it became public that Pete was the winner of this year's medal, I commented to my wife that, although I had never given a citation for an AGU medalist, this was one I would really love to give. The reason is simple: there is no one in the world who better represents the standards of excellence that a hydrologist hopes to achieve and that hydrologists hope our discipline will attain than Peter Eagleson.Pete did not start his research career in hydrology. In fact, his Ph.D. thesis in 1956 and his research up to 1965 were mainly in the field of sediment sorting and transport by waves on beaches. During this period he also investigated problems related to flow-induced vibrations of plates. His research in these areas was extremely successful, producing three chapters in books and about 20 journal papers in addition to many technical reports and journal discussions. Indeed, Pete had made his mark in wave theory and sediment transport, but it was good fortune for our field that starting about 1964 his interest in hydrology overcame all his past experience and assured a reputation in the waves and sediment field, and thus he embarked on a new adventure—bringing into hydrology the scientific rigor that existed in more academically established disciplines. With his strong fluid mechanics background—he still teaches that subject to undergraduates at MIT—Pete was ideally suited to lead the field toward new problems and also toward new approaches to old problems . . . and this he did indeed! Just in 1967 he and his students published six papers, most of them in Water Resources Research, which had a strong, an almost immediate impact on the field of hydrology. Here was somebody who was tackling the modeling of overland flow with the scientific standards of fluid mechanics. At the same time, finally somebody had

  12. Analog of the Peter-Weyl expansion for Lorentz group

    NASA Astrophysics Data System (ADS)

    Perlov, Leonid

    2015-11-01

    The expansion of a square integrable function on SL(2, C) into the sum of the principal series matrix coefficients with the specially selected representation parameters was recently used in the Loop Quantum Gravity [C. Rovelli and F. Vidotto, Covariant Loop Quantum Gravity: An Elementary Introduction to Quantum Gravity and Spinfoam Theory (Cambridge University Press, Cambridge, 2014) and C. Rovelli, Classical Quantum Gravity 28(11), 114005 (2011)]. In this paper, we prove that the sum used originally in the Loop Quantum Gravity: ∑ j = 0 ∞ ∑ |m| ≤ j ∑ |n| ≤ j Dj m , j n ( j , τ j ) ( g ) , where j, m, n ∈ Z, τ ∈ C is convergent to a function on SL(2, C); however, the limit is not a square integrable function; therefore, such sums cannot be used for the Peter-Weyl like expansion. We propose the alternative expansion and prove that for each fixed m: ∑ j = m ∞ D j m , j m ( j , τ j ) ( g ) is convergent and that the limit is a square integrable function on SL(2, C). We then prove the analog of the Peter-Weyl expansion: any ψ(g) ∈ L2(SL(2, C)) can be decomposed into the sum: ψ ( g ) = ∑ j = m ∞ j 2 ( 1 + τ 2 ) c j m m D j m , j m ( j , τ j ) ( g ) , with the Fourier coefficients c j m m = ∫ S L ( 2 , C ) ψ ( g ) Dj m , j m j , τ j ( g ) ¯ d g , g ∈ SL(2, C), τ ∈ C, τ ≠ i, - i, j, m ∈ Z, m is fixed. We also prove convergence of the sums ∑ j = |p| ∞ ∑ |m| ≤ j ∑ |n| ≤ j dp m /j 2 Dj m , j n ( j , τ j ) ( g ) , where d|p| m /j 2 = ( j + 1 ) /1 2 ∫ S U ( 2 ) ϕ ( u ) D|p| m /j 2 ( u ) ¯ d u is ϕ(u)'s Fourier transform and p, j, m, n ∈ Z, τ ∈ C, u ∈ SU(2), g ∈ SL(2, C), thus establishing the map between the square integrable functions on SU(2) and the space of the functions on SL(2, C). Such maps were first used in Rovelli [Class. Quant. Grav. 28, 11 (2011)].

  13. Peter Agre, 2003 Nobel Prize winner in chemistry.

    PubMed

    Knepper, Mark A; Nielsen, Soren

    2004-04-01

    Peter C. Agre, an American Society of Nephrology member, is the recipient of the 2003 Nobel Prize in Chemistry for his discovery of the aquaporin water channels. The function of many cells requires that water move rapidly into and out of them. There was only indirect evidence that proteinaceous channels provide this vital activity until Agre and colleagues purified aquaporin-1 from human erythrocytes and reported its cDNA sequence. They proved that aquaporin-1 is a specific water channel by cRNA expression studies in Xenopus oocytes and by functional reconstitution of transport activity in liposomes after the incorporation of the purified protein. These findings sparked a veritable explosion of work that affects several long-standing areas of investigation such as the biophysics of water permeation across cell membranes, the structural biology of integral membrane proteins, the physiology of fluid transport in the kidney and other organs, and the pathophysiological basis of inherited and acquired disorders of water balance. Agre's discovery of the first water channel has spurred a revolution in animal and plant physiology and in medicine. PMID:15034115

  14. Peter Howard Elworthy (1933-1995): a biographical note.

    PubMed

    Florence, A T

    1997-06-01

    Peter Elworthy had a considerable influence on pharmaceutical science, education and practice, in the UK. He died in December 1995 at the early age of 62, but he had retired from full time academic work from his post as Professor of Pharmacy and Head of the Department of Pharmacy in the University of Manchester twelve years earlier. Concerned about his health but also not a little disillusioned by the multiple pressures placed even then on senior academics, he foresaw the era of cuts and the central oversight and restrictions. His heart was elsewhere. In his 1976 Harrison Memorial Lecture (reproduced in this issue) he said: "Looking back, I have the feeling of having been very lucky. 'Much have I travell'd in the realms of gold, and many goodly states and kingdoms seen.' My main interest has been in the phenomenon of micellization. The subject has been of absorbing interest, and continually shows new bright facets which lead to new scientific advances. Travelling in the realms of gold has nothing to do with gold, but to me it means travelling in sunlight, which illuminates things brightly, and makes visible new facts, which have been invisible before. Occasionally dark clouds form; they are the disappointments and frustrations, but we need them in order to be able to recognize the sunlight by contrast." PMID:9330193

  15. Becoming a peter pan: omnipotence, dependency and the Ferenczian child.

    PubMed

    Bar-Haim, Shaul

    2015-03-01

    The aim of this paper is to provide a short history of the changes in Ferenczi's concept of early childhood, during the two decade period, 1913-1932. Initially, Ferenczi mainly emphasized children's feelings of omnipotence, which enable them to perceive themselves as strong, independent and capable human beings. By the mid-1920s, however, he felt that his earlier work did not give a good account of what comes after the stage of omnipotence, and that it did not adequately describe the difficulties in the transition from pleasure to reality principles. However, in his Clinical Diary, Ferenczi became fully aware of how fragile and insecure children are, and therefore how dangerous-yet necessary-it is for them to abandon the "stage of omnipotence" and to gain a "sense of reality". For Ferenczi, traumatized children are children who had not been loved in their early childhood, and therefore could not develop the capacity to make the journey from pleasure principle to that of reality. It will be suggested that a paradigmatic example for this kind of child is Peter Pan. PMID:25720781

  16. Peters anomaly in a red kangaroo (Macropus rufus).

    PubMed

    Suedmeyer, Wm Kirk; Pearce, Jacqueline; Persky, Meredith; Houck, Marlys L

    2014-09-01

    A 10-mo-old female red kangaroo (Macropus rufus) presented with a unilateral congenital corneal opacity OD. Complete ophthalmic examination revealed a shallow anterior chamber and a focal area of corneal edema with multiple persistent pupillary membranes extending from the iris colarette to the corneal endothelium adjacent to the edematous area of cornea. High-resolution B-scan ultrasound of the anterior segment showed an area consistent with thinning of Descemet's membrane in the area of corneal edema. Ophthalmic examination and ultrasound findings are consistent with a diagnosis of Peters anomaly, a form of anterior segment dysgenesis. An electroretinogram performed on the affected animal did not reveal any specific abnormalities. Karyotype analyses revealed a normal diploid number (2n = 20, -XX), with an abnormal pericentric inversion in the second largest chromosomal pair. The kangaroo exhibits mild compensated vision deficits in the affected eye. The maternal and paternal adult pairing has been discontinued in an effort to prevent future offspring anomalies. PMID:25314851

  17. Romantic Resonances in the Rhetoric of Peter Elbow's "Writing Without Teachers."

    ERIC Educational Resources Information Center

    Yager, Kristi

    1996-01-01

    Seeks to uncover the historical roots within English Romanticism of Peter Elbow's thinking in order to show the depth and complexity of his assumptions about writing. Implicitly refutes charges questioning the intellectual credibility of Elbow's work. (TB)

  18. 8q21.11 microdeletion in two patients with syndromic peters anomaly.

    PubMed

    Happ, Hannah; Schilter, Kala F; Weh, Eric; Reis, Linda M; Semina, Elena V

    2016-09-01

    Peters anomaly is a form of anterior segment dysgenesis characterized by central ocular opacity and corneo-lenticular adhesions. Isolated and syndromic Peters anomaly can be observed and demonstrate significant genetic heterogeneity. We report the identification of overlapping 8q21.11 deletions in two patients with syndromic Peters anomaly via whole exome sequencing and chromosomal microarray analyses. Microdeletions of 8q21.11 were recently reported in 10 patients with highly variable phenotypes involving craniofacial features, ptosis, intellectual disability, abnormalities of the hands/feet and other defects; sclerocornea and/or microphthalmia were reported in three cases. The two additional cases presented in this report expand the phenotypic spectrum of 8q21.11 microdeletions to include Peters anomaly (seen in both patients) and persistent primary dentition (seen in one patient with a larger deletion). The two novel deletions include the ZFHX4 and PEX2 genes, which were also affected in all three previous cases involving ocular anomalies. Screening of the remaining alleles of ZFHX4 and PEX2 did not identify any additional likely pathogenic variants in either patient, suggesting a dominant mechanism (haploinsufficiency) for the identified deletion. This report provides further insight into the phenotypes associated with 8q21.11 deletions and, for the first time, reports Peters anomaly as an additional ocular feature; screening for copy number variations of the 8q21.11 region should be considered in patients with Peters anomaly and related syndromic features. © 2016 Wiley Periodicals, Inc. PMID:27378168

  19. Sophus Peter Tromholt: an outstanding pioneer in auroral research

    NASA Astrophysics Data System (ADS)

    Moss, K.; Stauning, P.

    2012-03-01

    The Danish school teacher Sophus Peter Tromholt (1851-1896) was self-taught in physics, astronomy, and auroral sciences. Still, he was one of the brightest auroral researchers of the 19th century. He was the first scientist ever to organize and analyse correlated auroral observations over a wide area (entire Scandinavia) moving away from incomplete localized observations. Tromholt documented the relation between auroras and sunspots and demonstrated the daily, seasonal and solar cycle-related variations in high-latitude auroral occurrence frequencies. Thus, Tromholt was the first ever to deduce from auroral observations the variations associated with what is now known as the auroral oval termed so by Khorosheva (1962) and Feldstein (1963) more than 80 yr later. He made reliable and accurate estimates of the heights of auroras several decades before this important issue was finally settled through Størmer's brilliant photographic technique. In addition to his three major scientific works (Tromholt, 1880a, 1882a, and 1885a), he wrote numerous short science notes and made huge efforts to collect historical auroral observations (Tromholt, 1898). Furthermore, Tromholt wrote a large number of popular science articles in newspapers and journals and made lecture tours all over Scandinavia and Germany, contributing to enhance the public educational level and awareness. He devoted most of his life to auroral research but as a self-taught scientist, he received little acclaim within the contemporary academic scientific society. With his non-academic background, trained at a college of education - not a university - he was never offered a position at a university or a research institution. However, Sophus Tromholt was an outstanding pioneer in auroral research.

  20. More deletions in the 5{prime} region than in the central region of the dystrophin gene were identified among Filipino Duchenne and Becker muscular dystrophy patients

    SciTech Connect

    1995-11-06

    This report describes mutations in the dystrophin gene and the frequency of these mutations in Filipino pedigrees with Duchenne and Becker muscular dystrophy (DMD/BMD). The findings suggest the presence of genetic variability among DMD/BMD patients in different populations. 13 refs., 1 tab.

  1. Energy conservation equation for a radiating pointlike charge in the context of the Abraham-Lorentz versus the Abraham-Becker radiation-reaction force

    NASA Astrophysics Data System (ADS)

    Bellotti, U.; Bornatici, M.

    1997-12-01

    With reference to a radiating pointlike charge, the energy conservation equation comprising the effect of the Abraham-Lorentz radiation-reaction force is contrasted with the incorrect energy conservation equation obtained by Hartemann and Luhmann [Phys. Rev. Lett. 74, 1107 (1995)] on considering instead the Abraham-Becker force that accounts only for a part of the instantaneous radiation-reaction force.

  2. Professor Peter Choyce: an early pioneer of intraocular lenses and corneal/refractive surgery.

    PubMed

    Pandey, Suresh K; Apple, David J

    2005-06-01

    Professor Peter Choyce, FRCS, DOMS, MS, was one of the pioneers of intraocular lens implant surgery. He developed an interest in artificial lens implantation following cataract surgery, a procedure that was widely criticized by the ophthalmic establishment in the UK, Europe, North America and other countries. Owing to the opposition to the intraocular lenses, Peter Choyce together with Sir Harold Ridley co-founded the International Intraocular Implant Club in 1966, which was responsible for the gradual acceptance of artificial lens implantation. Peter Choyce developed several models of intraocular lens, but did not patent the majority of them. The Choyce Mark IX, manufactured by Rayner Intraocular Lenses, became the first US Food and Drug Administration-approved intraocular lens in 1981. A review of Peter Choyce's record confirms a significant number of original innovations in the field of anterior segment surgery, including many procedures taken for granted today, but not associated with his name. These include early work on both kerato- and intraocular lens-refractive procedures, keratoprosthesis, pioneering paediatric implant procedures and others. Unfortunately his tenacious adherence to anterior chamber lens technology, while in general clinically sound, caused many to question his influence and hence he remained poorly understood even until after his death. He passed away on 8 August 2001 after a long fight with colon cancer. In this article, we provide evidence and elaborate Peter Choyce's accomplishments, which places him as one of the most innovative ophthalmologist in his surgical field in the twentieth century. PMID:15932534

  3. Mutation analysis in Duchenne and Becker muscular dystrophy patients from Bulgaria shows a peculiar distribution of breakpoints by intron

    SciTech Connect

    Todorova, A.; Bronzova, J.; Kremensky, I.

    1996-10-02

    For the first time in Bulgaria, a deletion/duplication screening was performed on a group of 84 unrelated Duchenne/Becker muscular dystrophy patients, and the breakpoint distribution in the dystrophin gene was analyzed. Intragenic deletions were detected in 67.8% of patients, and intragenic duplications in 2.4%. A peculiar distribution of deletion breakpoints was found. Only 13.2% of the deletion breakpoints fell in the {open_quotes}classical{close_quotes} hot spot in intron 44, whereas the majority (> 54%) were located within the segment encompassing introns 45-51, which includes intron 50, the richest in breakpoints (16%) in the Bulgarian sample. Comparison with data from Greece and Turkey points at the probable existence of a deletion hot spot within intron 50, which might be a characteristic of populations of the Balkan region. 17 refs., 2 figs.

  4. Comment on "Carbon farming in hot, dry coastal areas: an option for climate change mitigation" by Becker et al. (2013)

    NASA Astrophysics Data System (ADS)

    Heimann, M.

    2013-08-01

    Becker et al. (2013) argue that an afforestation of 0.73 109 ha with Jatropha curcas plants would generate an additional terrestrial carbon sink of 4.3 PgC yr-1, enough to stabilise the atmospheric mixing ratio of carbon dioxide (CO2) at current levels. However, this is not consistent with the dynamics of the global carbon cycle. Using a well established global carbon cycle model, the effect of adding such a hypothetical sink leads to a reduction of atmospheric CO2 levels in the year 2030 by 25 ppm compared to a reference scenario. However, the stabilisation of the atmospheric CO2 concentration requires a much larger additional sink or corresponding reduction of anthropogenic emissions.

  5. Comment on "Carbon farming in hot, dry coastal areas: an option for climate change mitigation" by Becker et al. (2013)

    NASA Astrophysics Data System (ADS)

    Heimann, M.

    2014-01-01

    Becker et al. (2013) argue that an afforestation of 0.73 × 109 ha with Jatropha curcas plants would generate an additional terrestrial carbon sink of 4.3 PgC yr-1, enough to stabilise the atmospheric mixing ratio of carbon dioxide (CO2) at current levels. However, this is not consistent with the dynamics of the global carbon cycle. Using a well-established global carbon cycle model, the effect of adding such a hypothetical sink leads to a reduction of atmospheric CO2 levels in the year 2030 by 25 ppm compared to a reference scenario. However, the stabilisation of the atmospheric CO2 concentration requires a much larger additional sink or corresponding reduction of anthropogenic emissions.

  6. Obesity and Premature Loss of Mobility in Two Adolescents with Becker Muscular Dystrophy After HeartMate II Implantation.

    PubMed

    Hollander, Seth A; Rizzuto, Sandra; Hollander, Amanda M; Lin, Aileen; Liu, Esther; Murray, Jenna M; Almond, Christopher S; Rosenthal, David N

    2016-01-01

    Weight gain is common after implantation of continuous-flow ventricular assist devices. Obesity can have a significant negative impact on mobility. For adolescents with Becker muscular dystrophy (BMD), for whom the ability to ambulate often persists into the mid-3rd decade, preservation of functional ability is critical. We report two cases of Thoratec HeartMate II left ventricular assist device (LVAD) implantation in adolescents with BMD for whom postoperative weight gain contributed significantly to an accelerated loss of ambulation and, in one case, driveline fracture in the context of repeated falls. As LVADs become an increasingly common therapy for endstage heart failure in adolescents with BMD, care must be focused not only on maintenance of device functionality, but also on management of aggressive weight, and preservation of ambulation, and skeletal muscle strength. PMID:26461240

  7. The 2009 Lindau Nobel Laureate Meeting: Peter Agre, Chemistry 2003.

    PubMed

    Agre, Peter

    2009-01-01

    Peter Agre, born in 1949 in Northfield Minnesota, shared the 2003 Nobel Prize in Chemistry with Roderick MacKinnon for his discovery of aquaporins, the channel proteins that allow water to cross the cell membrane. Agre's interest medicine was inspired by the humanitarian efforts of the Medical Missionary program run by the Norwegians of his home community in Minnesota. Hoping to provide new treatments for diseases affecting the poor, he joined a cholera laboratory during medical school at Johns Hopkins. He found that he enjoyed biomedical research, and continued his laboratory studies for an additional year after medical school. Agre completed his clinical training at Case Western Hospitals of Cleveland and the University of North Carolina, and returned to Johns Hopkins in 1981. There, his serendipitous discovery of aquaporins was made while pursuing the identity of the Rhesus (Rh) antigen. For a century, physiologists and biophysicists had been trying to understand the mechanism by which fluid passed across the cell's plasma membrane. Biophysical evidence indicated a limit to passive diffusion of water, suggesting the existence of another mechanism for water transport across the membrane. The putative "water channel," however, could not be identified. In 1988, while attempting to purify the 30 kDa Rh protein, Agre and colleagues began investigating a 28 kDa contaminant that they believed to be a proteolytic fragment of the Rh protein. Subsequent studies over the next 3-4 years revealed that the contaminant was a membrane-spanning oligomeric protein, unrelated to the Rh antigen, and that it was highly abundant in renal tubules and red blood cells. Still, they could not assign a function to it. The breakthrough came following a visit with his friend and former mentor John Parker. After Agre described the properties of the mysterious 28 kDa protein, Parker suggested that it might be the long-sought-after water channel. Agre and colleagues tested this idea by

  8. The 2009 Lindau Nobel Laureate Meeting: Peter Agre, Chemistry 2003

    PubMed Central

    Agre, Peter

    2009-01-01

    Peter Agre, born in 1949 in Northfield Minnesota, shared the 2003 Nobel Prize in Chemistry with Roderick MacKinnon for his discovery of aquaporins, the channel proteins that allow water to cross the cell membrane. Agre's interest medicine was inspired by the humanitarian efforts of the Medical Missionary program run by the Norwegians of his home community in Minnesota. Hoping to provide new treatments for diseases affecting the poor, he joined a cholera laboratory during medical school at Johns Hopkins. He found that he enjoyed biomedical research, and continued his laboratory studies for an additional year after medical school. Agre completed his clinical training at Case Western Hospitals of Cleveland and the University of North Carolina, and returned to Johns Hopkins in 1981. There, his serendipitous discovery of aquaporins was made while pursuing the identity of the Rhesus (Rh) antigen. For a century, physiologists and biophysicists had been trying to understand the mechanism by which fluid passed across the cell's plasma membrane. Biophysical evidence indicated a limit to passive diffusion of water, suggesting the existence of another mechanism for water transport across the membrane. The putative "water channel," however, could not be identified. In 1988, while attempting to purify the 30kDa Rh protein, Agre and colleagues began investigating a 28 kDa contaminant that they believed to be a proteolytic fragment of the Rh protein. Subsequent studies over the next 3-4 years revealed that the contaminant was a membrane-spanning oligomeric protein, unrelated to the Rh antigen, and that it was highly abundant in renal tubules and red blood cells. Still, they could not assign a function to it. The breakthrough came following a visit with his friend and former mentor John Parker. After Agre described the properties of the mysterious 28 kDa protein, Parker suggested that it might be the long-sought-after water channel. Agre and colleagues tested this idea by

  9. K istorii goroskopa Petra Velikogo %t On the history of horoscope of Peter the Great

    NASA Astrophysics Data System (ADS)

    Bronshtehn, V. A.

    In the first part of the paper the question is discussed if Simeon Polotsky (1629-1680), poet and teacher of children of the Russian tsar Alexei Mikhailovich, was also the author of the horoscope of his son, in the future - Russian emperor Peter the Great, born in 1672. The poems by Simeon Polotsky with astrological contents are analyzed. The conclusion is supported that he could be the author of Peter the Great horoscope. In the second part a recently found text of the horoscope of Peter the Great reconstructed in 1775 by Russian astronomer Andrei Lexell of the request of historian G. F. Miller is published and discussed. It is also compared with texts previously published (in 1842) by Russian historians Pogodin and Polevoi.

  10. Theories of Power, Poverty, and Law: In Commemoration of the Contributions of Peter Bachrach--Empowerment and Poverty

    ERIC Educational Resources Information Center

    Levi, Margaret

    2010-01-01

    My subject is the way Peter Bachrach addressed the question of poverty. But given that I was his student and research assistant and that I am a political scientist largely because of him, it is impossible to resist a few words about the experience of being in his classrooms. Peter was an inspiring teacher of politics. The substantive content of…

  11. 75 FR 63533 - Gulf & Ohio Railways Holding Co., Inc., H. Peter Claussen and Linda C. Claussen-Continuance in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Gulf & Ohio Railways Holding Co., Inc., H. Peter Claussen and Linda C... Co., Inc. (G&O), H. Peter Claussen and Linda C. Claussen (the Claussens), noncarriers, have filed...

  12. Interview with Peter McLaren, on His Work, on His Visit to Turkey and on Ongoing Popular Struggles

    ERIC Educational Resources Information Center

    Fassbinder, Samuel Day

    2013-01-01

    Peter McLaren is, as the back cover of his (2005) Capitalists & Conquerors: a critical pedagogy against empire says, "professor of urban education at the Graduate School of Education and Information Studies at the University of California, Los Angeles". Peter is also now a Distinguished Fellow in Critical Studies at Chapman…

  13. Is R. S. Peters' Way of Mentioning Women in His Texts Detrimental to Philosophy of Education? Some Considerations and Questions

    ERIC Educational Resources Information Center

    Lees, Helen E.

    2012-01-01

    Discussion in this article considers the unfortunate way R.S. Peters made mention of women when it was pertinent to his argumentation: portraying them, directly or indirectly, as abuse-able (murderable), deficient, aberrant, clueless and inconstant. It is argued that the high profile and esteem within which Peter's texts are held within philosophy…

  14. An Unusual Case of Peters Plus Syndrome with Sexual Ambiguity and Absence of Mutations in the B3GALTL Gene

    PubMed Central

    Siala, Olfa; Belguith, Neila; Fakhfakh, Faiza

    2013-01-01

    Background Peters Plus syndrome (MIM 261540) is a rare autosomal recessive condition characterized by ocular defects (typically Peters anomaly) and other systemic major/minor abnormalities. Mutations in the B3GALTL gene encoding the β-1,3-glucosyltransferase have been found in virtually all patients with typical Peters Plus syndrome. Case Presentation We report here a female patient with severe manifestations of Peters Plus syndrome including facial dysmorphism and bilateral corneal opacity associated with left renal pyelo-calicial dilatation and sexual ambiguity. Total sequencing of the B3GALTL gene revealed no mutation in the patient. Conclusion To our knowledge, sexual ambiguity has not previously been reported in Peters Plus syndrome so far, and renal malformation is also apparently rare in the syndrome. PMID:24427506

  15. Education, Philosophy and Politics: The Selected Works of Michael A. Peters. World Library of Educationalists

    ERIC Educational Resources Information Center

    Peters, Michael A.

    2012-01-01

    In the World Library of Educationalists series, international experts themselves compile career-long collections of what they judge to be their finest pieces--extracts from books, key articles, salient research findings, major theoretical and/practical contributions--so the world can read them in a single manageable volume. Michael A. Peters has…

  16. 14. Photocopy of a photographca. 1902taken by A.W. Peters showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photocopy of a photograph--ca. 1902--taken by A.W. Peters showing Eastwood and his party surveying for the Big Creek Project. The surveying party is visible in the upper right corner. Courtesy Mr. Charles Allan Whitney. - Little Rock Creek Dam, Little Rock Creek, Littlerock, Los Angeles County, CA

  17. Two Is the Beginning of the End: "Peter Pan" and the Doctrine of Reminiscence

    ERIC Educational Resources Information Center

    Hudson, Glenda A.

    2006-01-01

    This article considers J.M. Barrie's satirical treatment of the Platonic doctrine of reminiscence in "Peter Pan," and how Barrie's work both honors and undercuts it. It will first analyze the Platonic notion of the doctrine of reminiscence in Wordsworth's "Ode: Intimations of Immortality from Recollections of Early Childhood" (1807). It will then…

  18. An End to the Curious Social Construction of "Expressivism" and the Pragmatist Tradition of Peter Elbow.

    ERIC Educational Resources Information Center

    Jones, Donald C.

    Labeling Peter Elbow an "expressivist" is an ironic reduction of his multifaceted thought to a one-dimensional term at a time when postmodernism stresses heteroglossia. This paper outlines the recent history of "expressivism" to demonstrate its curious social construction. The paper then calls for an "end of expressivism," and this end refers not…

  19. Writing in the American Grain: Peter Elbow's and David Bartholomae's Emersonian Pedagogies of Empowerment.

    ERIC Educational Resources Information Center

    Wiley, Mark

    1990-01-01

    Argues that, although Peter Elbow's and David Bartholomae's pedagogies attempt in different ways to authorize students to write, both rely on the experience and resistance to language as the primary means of empowerment. Suggests that Elbow and Bartholomae must continually defer authority, keeping it suspended between experience and its…

  20. The Authority of Truth: Religion and the John Peter Zenger Case.

    ERIC Educational Resources Information Center

    Nord, David Paul

    An appreciation of the religious milieu of the John Peter Zenger libel case of 1735 can help explain the nature of the Zenger defense as prepared by Alexander Hamilton, the meaning of the jury's verdict, and the ambiguous legacy of the trial for freedom of expression in the United States. In essence, the case was a disputation on "truth" and on…

  1. Sandra Diane Knapp—Recipient of the 2008 Peter Raven Award

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dr. Sandra Knapp, Curator at Natural History Museum in London, is the 2009 recipient of the Peter Raven Award. This award is provided each year by the American Society of Plant Taxonomists to a plant systematist who has made exceptional efforts at outreach to nonscientists. This publication summariz...

  2. Respectability and Relevance: Reflections on Richard Peters and Analytic Philosophy of Education

    ERIC Educational Resources Information Center

    Snook, Ivan

    2013-01-01

    I argue that, after Dewey, Peters was the first modern philosopher of education to write material (in English) that was both philosophically respectable and relevant to the day-to-day concerns of teachers. Since then, some philosophers of education have remained (more or less) relevant but not really respectable while others have "taken off into…

  3. Reason and Virtues: The Paradox of R. S. Peters on Moral Education

    ERIC Educational Resources Information Center

    Haydon, Graham

    2009-01-01

    This article examines the work of R. S. Peters on moral development and moral education, as represented in his papers collected under that name, pointing out that these writings have been relatively neglected. It approaches these writings through the lens of the "familiar story" that philosophical work on this topic switched during, roughly, the…

  4. Transformation and Education: The Voice of the Learner in Peters' Concept of Teaching

    ERIC Educational Resources Information Center

    English, Andrea

    2009-01-01

    On several occasions in his work, R. S. Peters identifies a difficulty inherent in teaching that underscores the complexity of this relationship: the teacher has the task of passing on knowledge while at the same time allowing knowledge that is passed on to be criticised and revised by the learner. This inquiry asks: first, how does Peters…

  5. The Place of Philosophy in the Training of Teachers: Peters Revisited

    ERIC Educational Resources Information Center

    Clark, John A.

    2013-01-01

    In 1964, Richard Peters examined the place of philosophy in the training of teachers. He considered three things: Why should philosophy of education be included in the training of teachers; What portion of philosophy of education should be included; How should philosophy be taught to those training to be teachers. This article explores the context…

  6. The Possibilities of Transformation: Critical Research and Peter McLaren

    ERIC Educational Resources Information Center

    Porfilio, Brad J.

    2006-01-01

    The purpose of this paper is to unveil how Peter McLaren's revolutionary brand of pedagogy, multiculturalism, and research colored my two-year qualitative research study, which unearthed twenty White female future teachers' experiences and perceptions in relationship to computing technology and male-centered computing culture. His ideas positioned…

  7. ADENOCARCINOMA OF THE RETINAL PIGMENT EPITHELIUM IN THE GUPPY POECILIA RETICULATA PETERS

    EPA Science Inventory

    A single case of adenocarcinoma of the retinal pigment epithelium occurred in a guppy, Poecilia reticulata Peters. his is the first such tumor reported from fishes. he left eye of the affected fish was severely exophthalmic because of a large intraocular tumor mass. he tumor, whi...

  8. Perspective on Open-Access Publishing: An Interview with Peter Suber

    ERIC Educational Resources Information Center

    Cornwell, Reid; Suber, Peter

    2008-01-01

    In this edition of Perspectives, Reid Cornwell discusses open-access publishing with Peter Suber, senior researcher at the Scholarly Publishing and Academic Resources Coalition, senior research professor of philosophy at Earlham College, and currently visiting fellow at Yale Law School. Open access means that scholarly work is freely and openly…

  9. Instruction in the Making: Peter Ramus and the Beginnings of Modern Schooling.

    ERIC Educational Resources Information Center

    Hamilton, David

    This paper examines educational practice between 1450-1650, highlighting 16th century educationist, Peter Ramus, whose work is remembered in the "History of Western Philosophy" as fostering a "pedagogic marvel." Ramus' work has received scant attention from English-speaking educationists, and his niche within the educational pantheon is…

  10. Robbing Peter to pay Paul: smarter re-allocation of dollars bring relief!

    PubMed

    Ledlow, Gerald R; Cwiek, Mark

    2002-01-01

    The dynamic tension facing health care organizations today is that of lower third-party payments and higher costs. The ever-present financial squeeze results in daily stressors for health care executives attempting to provide services with diminishing resources. How can one continue to "rob Peter to pay Paul," to make ends meet and stretch every dollar? PMID:12355621

  11. Michael Peters' Lyotardian Account of Postmodernism and Education: Some Epistemic Problems and Naturalistic Solutions

    ERIC Educational Resources Information Center

    Clark, John A.

    2006-01-01

    Postmodernism has established a significant hold in educational thought and some of the most important ideas are to be found in the writings of Michael Peters. This paper examines his postmodern stance and use of Lyotard's account of knowledge, and from a naturalist point of view raises a number of objections centred on science as a metanarrative,…

  12. Remaking Critical Pedagogy: Peter McLaren's Contribution to a Collective Work

    ERIC Educational Resources Information Center

    Martin, Gregory

    2006-01-01

    This article explores the collective works of Peter McLaren and his contribution to critical pedagogy within the field of education and beyond the academy. To understand how McLaren's work took a radical turn in the 1990s, the article traces the historical development of his praxis. In particular, McLaren's engagement with the postmodern Left and…

  13. Communicating Chemistry from "Molecules" to International Efforts: An Interview with Peter Atkins

    ERIC Educational Resources Information Center

    Cardellini, Liberato

    2008-01-01

    In this interview, Peter Atkins explains the deep motivations that compel him to sit at his desk at 6 AM writing books and textbooks. He discusses the four principal elements that help to make a chemistry textbook successful, including the secret ingredient. He also discusses the importance of problem solving, the interaction of multimedia, and…

  14. The Peter Effect Revisited: Reading Habits and Attitudes of College Students

    ERIC Educational Resources Information Center

    Applegate, Anthony J.; Applegate, Mary DeKonty; Mercantini, Martha A.; McGeehan, Catherine M.; Cobb, Jeanne B.; DeBoy, Joanne R.; Modla, Virginia B.; Lewinski, Kimberly E.

    2014-01-01

    Certainly a primary goal of literacy education is the creation of avid, enthusiastic, and highly motivated readers. However, in this article revisiting the Peter Effect (Applegate & Applegate, 2004), researchers surveyed more than 1,000 college sophomores and found strikingly low levels of enthusiasm for reading. Only 46.6% of surveyed…

  15. Two Causes of Underachievement--The Scapegoat Phenomenon and the Peter Pan Syndrome. Part II.

    ERIC Educational Resources Information Center

    Grau, Phyllis Nelson

    1986-01-01

    Two profiles of underachievement are described: the Peter Pan Syndrome, characterized by irresponsibility, anxiety, loneliness, sex role conflict, and narcissism, and the scapegoating phenomenon, in which children acquire negative self-images from victimization experiences. Prognoses and recommendations for each are offered. (Author/CL)

  16. Behavioral Determinants of Drug Action: The Contributions of Peter B. Dews

    ERIC Educational Resources Information Center

    Barrett, James E.

    2006-01-01

    Peter B. Dews played a significant role in shaping the distinctive characteristics and defining the underlying principles of the discipline of behavioral pharmacology. His early and sophisticated use of schedules of reinforcement in the 1950s, incorporated from research in the experimental analysis of behavior and integrated into the discipline of…

  17. "Operating on a Basis of Student Consent": Peter Medway's Work in "Finding a Language"

    ERIC Educational Resources Information Center

    Burgess, Tony

    2015-01-01

    Written nearly 40 years ago, Peter Medway's "Finding a Language" continues to be an arresting read, which offers a powerful vision of what might be possible in education. In this brief introduction, I set the work in context, referring to ideas that Pete engaged with and recalling a little of the times.

  18. R. S. Peters and J. H. Newman on the Aims of Education

    ERIC Educational Resources Information Center

    Ozolins, Janis T.

    2013-01-01

    R. S. Peters never explicitly talks about wisdom as being an aim of education. He does, however, in numerous places, emphasize that education is of the whole person and that, whatever else it might be about, it involves the development of knowledge and understanding. Being educated, he claims, is incompatible with being narrowly specialized.…

  19. Teaching Behavior Analysis and Psychology in Social Context: An Interview with Peter Harzem.

    ERIC Educational Resources Information Center

    Buskist, William

    2000-01-01

    Presents an interview with Peter Harzem, the Hudson Professor of Psychology at Auburn University (Alabama). Addresses such issues as teaching students about behavior analysis, the differences between classical and operant conditioning, reinforcement and behaviorism, and how one can become a better teacher. (CMK)

  20. Risk Factors Associated With Complication Rates of Becker-Type Expander Implants in Relation to Implant Survival: Review of 314 Implants in 237 Patients.

    PubMed

    Taboada-Suarez, Antonio; Brea-García, Beatriz; Magán-Muñoz, Fernando; Couto-González, Iván; González-Álvarez, Eduardo

    2015-12-01

    Although autologous tissue reconstruction is the best option for breast reconstruction, using implants is still a reliable and simple method, offering acceptable aesthetic results. Becker-type implants are permanent implants that offer a 1-stage reconstructive option. A retrospective study was carried out in our center reviewing the clinical reports of 237 patients, in whom a total of 314 Becker-type prostheses were implanted. Overall survival was calculated using a Kaplan-Meier estimate. Cox proportional hazard models were used to calculate adjusted hazard ratios. At the end of the study, 214 expanders (68.15%) presented no complications, 40 (12.47%) developed significant capsular contracture, in 27 (8.60%) infection occurred, 24 (7.64%) suffered minor complications, and 9 (2.87%) ruptured. The mean survival time of the expanders was 120.41 months (95% CI: 109.62, 131.19). Radiotherapy, chemotherapy, high Molecular Immunology Borstel, age, mastectomy performed previously to the implant, ductal carcinoma, advanced tumoral stage, experience of the surgeon, and Becker 35-type implants were significantly related to a high number of complications in relation to the survival of the implants. Cox regression analysis revealed that the main risk factors for the survival of expander implants included radiotherapy and surgeon experience. The complication hazard ratio or relative risk caused by these 2 factors was 1.976 and 1.680, respectively. One-stage reconstruction using Becker-type expanders is an appropriate, simple, and reliable option in delayed breast reconstruction in patients who have not received radiotherapy and as long as the procedure is carried out by surgeons skilled in the technique. PMID:25003425

  1. Is mammary reconstruction with the anatomical Becker expander a simple procedure? Complications and hidden problems leading to secondary surgical procedures: a follow-up study.

    PubMed

    Farace, Francesco; Faenza, Mario; Bulla, Antonio; Rubino, Corrado; Campus, Gian Vittorio

    2013-06-01

    Debate over the role of Becker expander implants (BEIs) in breast reconstruction is still ongoing. There are no clear indications for BEI use. The main indications for BEI use are one-stage breast reconstruction procedure and congenital breast deformities correction, due to the postoperative ability to vary BEI volume. Recent studies showed that BEIs were removed 5 years after mammary reconstruction in 68% of operated patients. This entails a further surgical procedure. BEIs should not, therefore, be regarded as one-stage prostheses. We performed a case-series study of breast reconstructions with anatomically shaped Becker-35™ implants, in order to highlight complications and to flag unseen problems, which might entail a second surgical procedure. A total of 229 patients, reconstructed from 2005 to 2010, were enrolled in this study. Data relating to implant type, volume, mean operative time and complications were recorded. All the patients underwent the same surgical procedure. The minimum follow-up period was 18 months. During a 5-year follow-up, 99 patients required secondary surgery to correct their complications or sequelae; 46 of them underwent BEI removal within 2 years of implantation, 56 within 3 years, 65 within 4 years and 74 within 5 years. Our findings show that two different sorts of complications can arise with these devices, leading to premature implant removal, one common to any breast implant and one peculiar to BEIs. The Becker implant is a permanent expander. Surgeons must, therefore, be aware that, once positioned, the Becker expander cannot be adjusted at a later date, as in two-stage expander/prosthesis reconstructions for instance. Surgeons must have a clear understanding of possible BEI complications in order to be able to discuss these with their patients. Therefore, only surgeons experienced in breast reconstruction should use BEIs. PMID:23478009

  2. [Successful anesthetic management of laparoscopic rectopexy using rocuronium and sugammadex in a patient with Becker muscular dystrophy].

    PubMed

    Yamaguchi, Satoshi; Ohno, Giichiro; Kitamura, Jiro

    2014-10-01

    A 70-year-old man with Becker muscular dystrophy (BMD) underwent laparoscopic rectopexy under general anesthesia. For anesthetic induction, we administered total 0.6 mg · kg-1 of rocuronium with titration. Eight minutes later, train-of-four (TOF) count reached to 0 and the patient was intubated smoothly. One hundred and five minutes later, TOF ratio recovered to 100% and we administered rocuronium 10 mg additionally. Surgery was finished without any problems 95 minutes after thereafter. TOF ratio was 45% and we administered sugammadex 3 mg · kg-1, reversing neuromuscular blockade to TOF ratio 100% within 1.5 minute. The patient awoke clearly and respiratory condition was good. He was extubated without remaining neuromuscular blockade. Postoperative course was stable and there was no serious adverse effect on his muscular function intra- and post-operatively. In conclusion, rocuronium and sugammadex can be used safely and effectively in general anesthetic management for patients with muscular dystrophy. However, as the onset times and durations of these agents can be longer, we should administer these agents with titration carefully under periodic neuromuscular monitoring. PMID:25693344

  3. Absence of correlation between utrophin localization and quantity and the clinical severity in Duchenne/Becker dystrophies

    SciTech Connect

    Vainzof, M.; Passos-Bueno, M.R.; Man, N.; Zatz, M.

    1995-09-25

    While present in the surface membrane of embryonic muscle fibers, in adult normal muscle fibers, utrophin is restricted to the motor endplate and cells of blood vessel walls. However, the observation that utrophin is maintained in the extrajunctional plasma membrane in Duchenne (DMD) and in mdx muscle fibers has led to the suggestion that excess utrophin might compensate for dystrophin deficiency in the Xp21 muscular dystrophies. In order to detect an inverse correlation of utrophin presence and clinical severity, we have assessed utrophin distribution and quantity in DMD and Becker (BMD) patients of different ages and stages of clinical severity. All patients showed a positive discontinuous immunolabeling of utrophin on the sarcolemma, staining equally small and large muscle fibers, indicating that immature characteristics are maintained in such fibers. On Western blot, utrophin bands with concentrations 2- to 10-fold greater than in normal controls were detected in all DMD/BMD patients. However, no negative correlation was found between the amount of utrophin and the severity of clinical course, implying that the detectable utrophin levels in these patients did not compensate for dystrophin deficiency. In a DMD patient with growth hormone (GH) deficiency and a BMD-like clinical course, utrophin levels were comparable to the other typical DMD cases, which reinforces the hypothesis that the observed increase in utrophin is apparently not responsible for a milder clinical course in some patients with Xp21 muscular dystrophies. 35 refs., 2 figs., 1 tab.

  4. Genetic diagnosis of Duchenne/Becker muscular dystrophy using next-generation sequencing: validation analysis of DMD mutations.

    PubMed

    Okubo, Mariko; Minami, Narihiro; Goto, Kanako; Goto, Yuichi; Noguchi, Satoru; Mitsuhashi, Satomi; Nishino, Ichizo

    2016-06-01

    Duchenne and Becker muscular dystrophies (DMD/BMD) are the most common inherited neuromuscular disease. The genetic diagnosis is not easily made because of the large size of the dystrophin gene, complex mutational spectrum and high number of tests patients undergo for diagnosis. Multiplex ligation-dependent probe amplification (MLPA) has been used as the initial diagnostic test of choice. Although MLPA can diagnose 70% of DMD/BMD patients having deletions/duplications, the remaining 30% of patients with small mutations require further analysis, such as Sanger sequencing. We applied a high-throughput method using Ion Torrent next-generation sequencing technology and diagnosed 92% of patients with DMD/BMD in a single analysis. We designed a multiplex primer pool for DMD and sequenced 67 cases having different mutations: 37 with deletions/duplications and 30 with small mutations or short insertions/deletions in DMD, using an Ion PGM sequencer. The results were compared with those from MLPA or Sanger sequencing. All deletions were detected. In contrast, 50% of duplications were correctly identified compared with the MLPA method. Small insertions in consecutive bases could not be detected. We estimated that Ion Torrent sequencing could diagnose ~92% of DMD/BMD patients according to the mutational spectrum of our cohort. Our results clearly indicate that this method is suitable for routine clinical practice providing novel insights into comprehensive genetic information for future molecular therapy. PMID:26911353

  5. Characterization of genetic deletions in Becker muscular dystrophy using monoclonal antibodies against a deletion-prone region of dystrophin

    SciTech Connect

    Thanh, L.T.; Man, Nguyen Thi; Morris, G.E.

    1995-08-28

    We have produced a new panel of 20 monoclonal antibodies (mAbs) against a region of the dystrophin protein corresponding to a deletion-prone region of the Duchenne muscular dystrophy gene (exons 45-50). We show that immunohistochemistry or Western blotting with these {open_quotes}exon-specific{close_quotes} mAbs can provide a valuable addition to Southern blotting or PCR methods for the accurate identification of genetic deletions in Becker muscular dystrophy patients. The antibodies were mapped to the following exons: exon 45 (2 mAbs), exon 46 (6), exon 47 (1), exons 47/48 (4), exons 48-50 (6), and exon 50 (1). PCR amplification of single exons or groups of exons was used both to produce specific dystrophin immunogens and to map the mAbs obtained. PCR-mediated mutagenesis was also used to identify regions of dystrophin important for mAb binding. Because the mAbs can be used to characterize the dystrophin produced by individual muscle fibres, they will also be useful for studying {open_quotes}revertant{close_quotes} fibres in Duchenne muscle and for monitoring the results of myoblast therapy trials in MD patients with deletions in this region of the dystrophin gene. 27 refs., 7 figs., 3 tabs.

  6. Becker Muscular Dystrophy (BMD) caused by duplication of exons 3-6 of the dystrophin gene presenting as dilated cardiomyopathy

    SciTech Connect

    Tsai, A.C.; Allingham-Hawkins, D.J.; Becker, L.

    1994-09-01

    X-linked dilated cardiomyopathy (XLCM) is a progressive myocardial disease presenting with congestive heart failure in teenage males without clinical signs of skeletal myopathy. Tight linkage of XLCM to the DMD locus has been demonstrated; it has been suggested that, at least in some families, XLCM is a {open_quotes}dystrophinopathy.{close_quotes} We report a 14-year-old boy who presented with acute heart failure due to dilated cardiomyopathy. He had no history of muscle weakness, but physical examination revealed pseudohypertrophy of the calf muscles. He subsequently received a heart transplantation. Family history was negative. Serum CK level at the time of diagnosis was 10,416. Myocardial biopsy showed no evidence of carditis. Dystrophin staining of cardiac and skeletal muscle with anti-sera to COOH and NH{sub 2}termini showed a patchy distribution of positivity suggestive of Becker muscular dystrophy. Analysis of 18 of the 79 dystrophin exons detected a duplication that included exons 3-6. The proband`s mother has an elevated serum CK and was confirmed to be a carrier of the same duplication. A mutation in the muscle promotor region of the dystrophin gene has been implicated in the etiology of SLCM. However, Towbin et al. (1991) argued that other 5{prime} mutations in the dystrophin gene could cause selective cardiomyopathy. The findings in our patient support the latter hypothesis. This suggests that there are multiple regions in the dystrophin gene which, when disrupted, can cause isolated dilated cardiomyopathy.

  7. Genetic diagnosis of Duchenne/Becker muscular dystrophy using next-generation sequencing: validation analysis of DMD mutations

    PubMed Central

    Okubo, Mariko; Minami, Narihiro; Goto, Kanako; Goto, Yuichi; Noguchi, Satoru; Mitsuhashi, Satomi; Nishino, Ichizo

    2016-01-01

    Duchenne and Becker muscular dystrophies (DMD/BMD) are the most common inherited neuromuscular disease. The genetic diagnosis is not easily made because of the large size of the dystrophin gene, complex mutational spectrum and high number of tests patients undergo for diagnosis. Multiplex ligation-dependent probe amplification (MLPA) has been used as the initial diagnostic test of choice. Although MLPA can diagnose 70% of DMD/BMD patients having deletions/duplications, the remaining 30% of patients with small mutations require further analysis, such as Sanger sequencing. We applied a high-throughput method using Ion Torrent next-generation sequencing technology and diagnosed 92% of patients with DMD/BMD in a single analysis. We designed a multiplex primer pool for DMD and sequenced 67 cases having different mutations: 37 with deletions/duplications and 30 with small mutations or short insertions/deletions in DMD, using an Ion PGM sequencer. The results were compared with those from MLPA or Sanger sequencing. All deletions were detected. In contrast, 50% of duplications were correctly identified compared with the MLPA method. Small insertions in consecutive bases could not be detected. We estimated that Ion Torrent sequencing could diagnose ~92% of DMD/BMD patients according to the mutational spectrum of our cohort. Our results clearly indicate that this method is suitable for routine clinical practice providing novel insights into comprehensive genetic information for future molecular therapy. PMID:26911353

  8. A girl with Peters plus syndrome associated with myelomeningocele and chronic renal failure.

    PubMed

    Motoyama, Osamu; Arai, Hiroko; Harada, Ryoko; Hasegawa, Kei; Iitaka, Kikuo

    2010-08-01

    A girl was born with sclerocornea of the right eye, corneal staphyloma of the left eye and lumbar myelomeningocele. The myelomeningocele was repaired soon after birth. The corneal staphyloma was perforated during infancy. She received keratoplasty and achieved light perception. Her right kidney revealed multicystic dysplasia and was non-functioning at birth. She had neurogenic bladder, and her renal function deteriorated gradually. Peters plus syndrome was diagnosed based on anterior ocular segment anomalies, short stature, developmental delay and characteristic face. Anterior ocular segment anomalies are rare findings, but seem to be occasionally associated with spina bifida and renal anomalies. Myelomeningocele and chronic renal failure in patients with Peters plus syndrome have not been reported to our knowledge. PMID:20424881

  9. Representing difference: Ernst Mach and Peter Salcher's ballistic-photographic experiments.

    PubMed

    Hoffmann, Christoph

    2009-03-01

    Photographs of the processes taking place in the air around a flying bullet, which the Austrian physicists Ernst Mach and Peter Salcher published in 1887, very soon became emblematic for the power of scientific photography over the human eye. But the main advantage was merely that photography allowed the phenomena in question to be recorded. This permitted a new experimental approach. The scientists were therefore not visualising phenomena by studying a single photograph but by comparing the differences between several. PMID:19201474

  10. An Interview with Peter McLaren: Comments on the State of the World-2005

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.

    2006-01-01

    Some of the wide range of thoughtful topics discussed in this interview with Peter McLaren include: (1) The top five points that McLaren tried to make in his book, "Capitalists and Conquerors: A Critical Pedagogy Against Empire"; (2) McLaren's thoughts on what he thinks the George Bush legend will be; (3) What led McLaren to ask,…

  11. A new species of the genus Diplocentrus Peters, 1861 (Scorpiones, Diplocentridae) from Oaxaca, Mexico

    PubMed Central

    Santibáñez-López, Carlos Eduardo

    2014-01-01

    Abstract A new species of the genus Diplocentrus Peters, 1861 is described, based on several specimens collected in the Mexican state of Oaxaca. It is characterized by a high telotarsal spiniform setae count (4-5/5:5/6:6/6:6/6-7), and the pectinal tooth counts of 12–15, mode = 13 (male) or 11–13, mode = 12 (female). With the description of this species, the diversity of the genus is increased to 51 species in Mexico. PMID:24899864

  12. Regional diagenetic patterns in the St. Peter Sandstone; implications for brine migration in the Illinois Basin

    USGS Publications Warehouse

    Pitman, Janet K.; Goldhaber, Martin B.; Spoetl, Christoph

    1997-01-01

    Diagenetic minerals and alteration patterns in the Ordovician St. Peter Sandstone, Illinois Basin, record varied hydrologic and chemical conditions during the basin?s long and complex geologic history. Major diagenetic events modifying the St. Peter Sandstone include (1) mechanical compaction, (2) early K-feldspar overgrowth and dolospar precipitation, (3) burial quartz, dolospar, anhydrite, and calcite cementation, and (4) carbonate-cement and K-feldspar grain dissolution. Radiometric age dates of authigenic K-feldspar and illite in combination with the reconstructed burial history of the St. Peter reveal that early-diagenetic K-feldspar and dolospar precipitated at shallow to moderate depths in the Devonian, whereas late-diagenetic quartz, dolospar, anhydrite, and calcite formed during deep burial in the Late Pennsylvanian to Early Permian. Stable-isotope geochemistry and fluid-inclusion paleothermometry suggest that burial cements precipitated from saline fluids over a wide temperature range. In the southern part of the basin, burial cements preserve a record of diagenetic effects that were in part controlled by fractures and hydrothermal-fluid circulation. Baroque dolospar cementation is the most significant of these effects.

  13. Dystrophin Hot-Spot Mutants Leading to Becker Muscular Dystrophy Insert More Deeply into Membrane Models than the Native Protein.

    PubMed

    Ameziane-Le Hir, Sarah; Paboeuf, Gilles; Tascon, Christophe; Hubert, Jean-François; Le Rumeur, Elisabeth; Vié, Véronique; Raguénès-Nicol, Céline

    2016-07-26

    Dystrophin (DYS) is a membrane skeleton protein whose mutations lead to lethal Duchenne muscular dystrophy or to the milder Becker muscular dystrophy (BMD). One third of BMD "in-frame" exon deletions are located in the region that codes for spectrin-like repeats R16 to R21. We focused on four prevalent mutated proteins deleted in this area (called RΔ45-47, RΔ45-48, RΔ45-49, and RΔ45-51 according to the deleted exon numbers), analyzing protein/membrane interactions. Two of the mutants, RΔ45-48 and RΔ45-51, led to mild pathologies and displayed a similar triple coiled-coil structure as the full-length DYS R16-21, whereas the two others, RΔ45-47 and RΔ45-49, induced more severe pathologies and showed "fractional" structures unrelated to the normal one. To explore lipid packing, small unilamellar liposomes (SUVs) and planar monolayers were used at various initial surface pressures. The dissociation constants determined by microscale thermophoresis (MST) were much higher for the full-length DYS R161-21 than for the mutants; thus the wild type protein has weaker SUV binding. Comparing surface pressures after protein adsorption and analysis of atomic force microscopy images of mixed protein/lipid monolayers revealed that the mutants insert more into the lipid monolayer than the wild type does. In fact, in both models every deletion mutant showed more interactions with membranes than the full-length protein did. This means that mutations in the R16-21 part of dystrophin disturb the protein's molecular behavior as it relates to membranes, regardless of whether the accompanying pathology is mild or severe. PMID:27367833

  14. Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies

    PubMed Central

    Janghra, Narinder; Morgan, Jennifer E.; Sewry, Caroline A.; Wilson, Francis X.; Davies, Kay E.; Muntoni, Francesco; Tinsley, Jonathon

    2016-01-01

    Duchenne muscular dystrophy is a severe and currently incurable progressive neuromuscular condition, caused by mutations in the DMD gene that result in the inability to produce dystrophin. Lack of dystrophin leads to loss of muscle fibres and a reduction in muscle mass and function. There is evidence from dystrophin-deficient mouse models that increasing levels of utrophin at the muscle fibre sarcolemma by genetic or pharmacological means significantly reduces the muscular dystrophy pathology. In order to determine the efficacy of utrophin modulators in clinical trials, it is necessary to accurately measure utrophin levels and other biomarkers on a fibre by fibre basis within a biopsy section. Our aim was to develop robust and reproducible staining and imaging protocols to quantify sarcolemmal utrophin levels, sarcolemmal dystrophin complex members and numbers of regenerating fibres within a biopsy section. We quantified sarcolemmal utrophin in mature and regenerating fibres and the percentage of regenerating muscle fibres, in muscle biopsies from Duchenne, the milder Becker muscular dystrophy and controls. Fluorescent immunostaining followed by image analysis was performed to quantify utrophin intensity and β-dystrogylcan and ɣ –sarcoglycan intensity at the sarcolemma. Antibodies to fetal and developmental myosins were used to identify regenerating muscle fibres allowing the accurate calculation of percentage regeneration fibres in the biopsy. Our results indicate that muscle biopsies from Becker muscular dystrophy patients have fewer numbers of regenerating fibres and reduced utrophin intensity compared to muscle biopsies from Duchenne muscular dystrophy patients. Of particular interest, we show for the first time that the percentage of regenerating muscle fibres within the muscle biopsy correlate with the clinical severity of Becker and Duchenne muscular dystrophy patients from whom the biopsy was taken. The ongoing development of these tools to quantify

  15. Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.

    PubMed

    Janghra, Narinder; Morgan, Jennifer E; Sewry, Caroline A; Wilson, Francis X; Davies, Kay E; Muntoni, Francesco; Tinsley, Jonathon

    2016-01-01

    Duchenne muscular dystrophy is a severe and currently incurable progressive neuromuscular condition, caused by mutations in the DMD gene that result in the inability to produce dystrophin. Lack of dystrophin leads to loss of muscle fibres and a reduction in muscle mass and function. There is evidence from dystrophin-deficient mouse models that increasing levels of utrophin at the muscle fibre sarcolemma by genetic or pharmacological means significantly reduces the muscular dystrophy pathology. In order to determine the efficacy of utrophin modulators in clinical trials, it is necessary to accurately measure utrophin levels and other biomarkers on a fibre by fibre basis within a biopsy section. Our aim was to develop robust and reproducible staining and imaging protocols to quantify sarcolemmal utrophin levels, sarcolemmal dystrophin complex members and numbers of regenerating fibres within a biopsy section. We quantified sarcolemmal utrophin in mature and regenerating fibres and the percentage of regenerating muscle fibres, in muscle biopsies from Duchenne, the milder Becker muscular dystrophy and controls. Fluorescent immunostaining followed by image analysis was performed to quantify utrophin intensity and β-dystrogylcan and ɣ -sarcoglycan intensity at the sarcolemma. Antibodies to fetal and developmental myosins were used to identify regenerating muscle fibres allowing the accurate calculation of percentage regeneration fibres in the biopsy. Our results indicate that muscle biopsies from Becker muscular dystrophy patients have fewer numbers of regenerating fibres and reduced utrophin intensity compared to muscle biopsies from Duchenne muscular dystrophy patients. Of particular interest, we show for the first time that the percentage of regenerating muscle fibres within the muscle biopsy correlate with the clinical severity of Becker and Duchenne muscular dystrophy patients from whom the biopsy was taken. The ongoing development of these tools to quantify

  16. Revision of New World Species of the Shore-fly Subgenus Allotrichoma Becker of the Genus Allotrichoma with Description of the Subgenus Neotrichoma (Diptera, Ephydridae, Hecamedini)

    PubMed Central

    Mathis, Wayne N.; Zatwarnicki, Tadeusz

    2012-01-01

    Abstract The New World species of the subgenera Allotrichoma Becker and Neotrichoma (new subgenus) are revised, including a phylogenetic analysis of the species groups and subgenera within the genus Allotrichoma. For phylogenetic perspective and to document the monophyly of the genus Allotrichoma and its included subgenera and species groups, we also provide a cladistic analysis of genera within the tribe Hecamedini. The ingroup included seven exemplar congeners from within Allotrichoma. Outgroup sampling included exemplars of other genera within Hecamedini and from the putative sister group, Lipochaetini, and to root the analysis, we used an exemplar of the tribe Discocerinini. Analyses with successive weighting and implied weighting recovered a monophyletic Allotrichoma and indicated clades within the genus. Eight new species are described (type locality in parenthesis): Allotrichoma bifurcatum (Utah. Utah: Lake Shore (40°06.9'N, 111°41.8'W; 1370 m)), Allotrichoma dynatum (Oregon. Benton: Finley National Wildlife Refuge (44°24.6'N, 123°19.5'W)), Allotrichoma occidentale (Oregon. Lake: Lakeview (44 km E; Drake Creek; 42°11'N, 119°59.3'W)), Allotrichoma robustum (California. Kern: Kern River (35°16.1'N, 119°18.4'W)), Allotrichoma sabroskyi (New Mexico. Sandoval: La Cueva (Junction of Highways 126 and 4; 35°52'N, 106°38.4'W; 2342 m)), Allotrichoma wallowa (Oregon Baker: Goose Creek (35 km E Baker City; 44°49.2'N, 117°27.79'W; 825 m)), Allotrichoma baliops (Florida. Monroe: Key West (Willie Ward Park; 24°32.9'N, 81°47.9'W)), and Allotrichoma insulare (Dominica. Cabrits Swamp (15°35'N, 61°29'W)). Within Allotrichoma, we recognize three subgenera of which one, Neotrichoma (type species: Allotrichoma atrilabre), is newly described. All known species from the New World are described with an emphasis on structures of the male terminalia, which are fully illustrated. Detailed locality data and distribution maps for the New World species are provided. A

  17. Some single-piston closed-cycle machines and Peter Tailer's thermal lag engine

    NASA Astrophysics Data System (ADS)

    West, C. D.

    1993-05-01

    Peter Tailer has devised, built, and operated a beautifully simple engine with a closed working gas cycle, external heating, and only a single piston. The aim of this paper is to cast some light on the possible modes of operation for his machine. The methods developed to analyze certain aspects of Stirling cycle engines, and especially the thermodynamic losses incurred in systems that are neither perfectly isothermal nor perfectly adiabatic, can be applied to Tailer's system. The results identify two idealized cycles fr such machines; relate those cycles to a single piston, ported cylinder machine proposed earlier; and offer a possible explanation for the success of the thermal lag engine.

  18. Language and Reality. Peter Mittelstaedt's Contributions to the Philosophy of Physics

    NASA Astrophysics Data System (ADS)

    Falkenburg, Brigitte

    2010-10-01

    The article investigates the way in which Peter Mittelstaedt has been contributing to the philosophy of physics for half a century. It is shown that he pursues a path between rationalism and empiricism in the sense of Erhard Scheibe’s philosophy of the physicists. Starting from Kant’s a priori he gives a rational reconstruction of the conceptual revolutions of 20th century physics. The central topic of his philosophy of physics is the quest for semantic self-consistency, which for quantum mechanics is a hard nut to crack.

  19. Communicating Chemistry from Molecules to International Efforts: An Interview with Peter Atkins

    NASA Astrophysics Data System (ADS)

    Cardellini, Liberato

    2008-06-01

    In this interview, Peter Atkins explains the deep motivations that compel him to sit at his desk at 6 AM writing books and textbooks. He discusses the four principal elements that help to make a chemistry textbook successful, including the secret ingredient. He also discusses the importance of problem solving, the interaction of multimedia, and the effect of the Web on textbooks. Finally, Atkins articulates the beliefs that learning chemistry opens our eyes to a deeper enjoyment of the world, that chemistry plumbs a deeper level of reality.

  20. Forest inventory: Peter T. Johnson Wildlife Mitigation Unit, Craig Mountain, Idaho. Final Report.

    SciTech Connect

    Narolski, Steven W.

    1996-12-01

    The primary objective of this report is to determine the quantity and quality of existing forest habitat types on the 59,991-acre Peter T. Johnson Wildlife Mitigation Unit (WMU). Products from this effort include a description of the ecological condition, a map of habitat types, and an inventory of forest resources on the WMU lands. The purpose of this and other resource inventories (plant and wildlife) is to assess the current resources condition of the WMU and to provide necessary information to generate a long-term management for this area.

  1. Peter Andreas Hansen und die astronomische Gemeinschaft - eine erste Auswertung des Hansen-Nachlasses.

    NASA Astrophysics Data System (ADS)

    Schwarz, O.; Strumpf, M.

    The literary assets of Peter Andreas Hansen are deposited in the Staatsarchiv Hamburg, the Forschungs- und Landesbibliothek Gotha and the Thüringer Staatsarchiv Gotha. They were never systematically investigated. The authors present here some results of a first evaluation. It was possible to reconstruct the historical events with regard to the maintenance of the Astronomische Nachrichten and the Altona observatory in 1854. Hansen was a successful teacher for many young astronomers. His way of stimulating the evolution of astronomy followed Zach's tradition.

  2. Effect of Ethanol on Branchial Adenosine Triphosphatases in Oreochromis mossambicus (Peters)

    PubMed Central

    Bhanu, Smitha V.; Philip, Babu

    2011-01-01

    The aim of this work was to determine the toxicity of ethanol in an aquatic system by means of bioassays with Oreochromis mossambicus (Peters) as a test organism. The study revealed changes in the gill ATPase activities. The results obtained indicated that ethanol brought about a decrease in the body weight, followed by significant inhibition on total ATPase, Na+/K+ ATPase, Ca2+ ATPase and Mg2+ ATPase activities. The studies also indicated that these can be employed as suitable biomarkers in ethanol related toxicity studies. PMID:21430917

  3. Evolution of Capsaicinoids in Peter Pepper (Capsicum annuum var. annuum) During Fruit Ripening.

    PubMed

    Barbero, Gerardo F; de Aguiar, Ana C; Carrera, Ceferino; Olachea, Ángel; Ferreiro-González, Marta; Martínez, Julian; Palma, Miguel; Barroso, Carmelo G

    2016-08-01

    The evolution of individual and total contents of capsaicinoids present in Peter peppers (Capsicum annuum var. annuum) at different ripening stages has been studied. Plants were grown in a glasshouse and the new peppers were marked in a temporal space of ten days. The extraction of capsaicinoids was performed by ultrasound-assisted extraction with MeOH. The capsaicinoids nordihydrocapsaicin (n-DHC), capsaicin, dihydrocapsaicin, homocapsaicin, and homodihydrocapsaicin were analyzed by ultraperformance liquid chromatography (UHPLC)-fluorescence and identified by UHPLC-Q-ToF-MS. The results indicate that the total capsaicinoids increase in a linear manner from the first point of harvest at ten days (0.283 mg/g FW) up to 90 days, at which point they reach a concentration of 1.301 mg/g FW. The evolution as a percentage of the individual capsaicinoids showed the initial predominance of capsaicin, dihydrocapsaicin, and n-DHC. Dihydrocapsaicin was the major capsaicinoid up to day 50 of maturation. After 50 days, capsaicin became the major capsaicinoid as the concentration of dihydrocapsaicin fell slightly. The time of harvest of Peter pepper based on the total capsaicinoids content should be performed as late as possible. In any case, harvesting should be performed before overripening of the fruit is observed. PMID:27416068

  4. A reconstructive surgeon's taste in art: Dr Peter Parker and the Lam Qua oil paintings.

    PubMed

    Chang, J

    1993-05-01

    Hidden within the basement archives of Yale University's Historical Medical Library lie the original oil painting collection and personal papers of the first American surgeon to practice in China. The Reverend Dr Peter Parker, a graduate of Yale, established the first American hospital in Guangzhou (formerly Canton) in 1835 and successfully introduced Western surgical techniques including amputation, anesthesia, and reconstructive surgery. In addition to this distinguished career of medical missionary service, Parker commissioned the Chinese artist Lam Qua to paint a fascinating series of portraits depicting patients with extreme tumor growths. In this article, Parker's own journals are examined to reveal both his missionary zeal and his frustrations working in China. Selected examples of the Lam Qua paintings are presented along with Parker's corresponding patient descriptions. These detailed patient reports give insight into the extent of surgical pathology as well as the relative brutality of surgical techniques in the early to mid-1800s. The historical significance of the Peter Parker-Lam Qua collaboration within the context of the Western transformation of Chinese art and medicine is also discussed. PMID:8342936

  5. Performance Evaluation Tests for Environmental Research (PETER): evaluation of 114 measures

    NASA Technical Reports Server (NTRS)

    Bittner, A. C. Jr; Carter, R. C.; Kennedy, R. S.; Harbeson, M. M.; Krause, M.

    1986-01-01

    The goal of the Performance Evaluation Tests for Environmental Research (PETER) Program was to identify a set of measures of human capabilities for use in the study of environmental and other time-course effects. 114 measures studied in the PETER Program were evaluated and categorized into four groups based upon task stability and task definition. The Recommended category contained 30 measures that clearly obtained total stabilization and had an acceptable level of reliability efficiency. The Acceptable-But-Redundant category contained 15 measures. The 37 measures in the Marginal category, which included an inordinate number of slope and other derived measures, usually had desirable features which were outweighed by faults. The 32 measures in the Unacceptable category had either differential instability or weak reliability efficiency. It is our opinion that the 30 measures in the Recommended category should be given first consideration for environmental research applications. Further, it is recommended that information pertaining to preexperimental practice requirements and stabilized reliabilities should be utilized in repeated-measures environmental studies.

  6. Abnormal short-latency synaptic plasticity in the motor cortex of subjects with Becker muscular dystrophy: a rTMS study.

    PubMed

    Golaszewski, Stefan; Schwenker, Kerstin; Bergmann, Jürgen; Brigo, Francesco; Christova, Monica; Trinka, Eugen; Nardone, Raffaele

    2016-01-01

    We used repetitive transcranial magnetic stimulation (rTMS) to further investigate motor cortex excitability in 13 patients with Becker muscular dystrophy (BMD), six of them with slight mental retardation. RTMS delivered at 5Hz frequency and suprathreshold intensity progressively increases the size of motor evoked potentials (MEPs) in healthy subjects; the rTMS-induced facilitation of MEPs was significantly reduced in the BMD patients mentally retarded or classified as borderline when compared with age-matched control subjects and the BMD patients with normal intelligence. The increase in the duration of the cortical silent period was similar in both patient groups and controls. These findings suggest an altered cortical short-term synaptic plasticity in glutamate-dependent excitatory circuits within the motor cortex in BMD patients with intellectual disabilities. RTMS studies may shed new light on the physiological mechanisms of cortical involvement in dystrophinopathies. PMID:26562314

  7. Analyses and description of geochemical samples, Peters Mountain Wilderness Study Area, Giles County, Virginia

    USGS Publications Warehouse

    Rait, Norma; Lesure, Frank Gardner

    1978-01-01

    Semiquantitative emission spectrographic analyses for 64 elements on 43 stream sediment and 73 rock samples from Peters Mountain Wilderness Study area, Giles County, Virginia, are reported here in detail. Locations for all samples are in Universal Transverse Mercator (UTM) coordinates. Brie[ descriptions of rock samples are also included. Rocks analysed are mostly sandstone. Samples of hematitic sandstone of the Rose Hill Formation and limonite-cemented sandstone of the Rocky Gap Sandstone contain high values of iron; these rocks are submarginal iron resources. Some of the same iron-rich samples have a little more barium, copper, cobalt, lead, silver, and/or zinc then average sandstone, but they do not suggest the presence of economic deposits of these metals. No other obviously anomalous values related to mineralized rock are present in the data.

  8. Yes! There is an ethics of care: an answer for Peter Allmark.

    PubMed Central

    Bradshaw, A

    1996-01-01

    This paper is a response to Peter Allmark's thesis that 'there can be no "caring" ethics'. It argues that the current preoccupation in nursing to define an ethics of care is a direct result of breaking nursing tradition. Subsequent attempts to find a moral basis for care, whether from subjective experimental perspectives such as described by Noddings, or from rational and detached approaches derived from Kant, are inevitably flawed. Writers may still implicitly presuppose a concept of care drawn from the Judaeo-Christian tradition but without explicit recourse to its moral basis nursing is left rudderless and potentially without purpose. The very concept of 'care' cut off from its roots becomes a meaningless term without either normative or descriptive content. PMID:8932719

  9. Peter Bourne's drug policy and the perils of a public health ethic, 1976-1978.

    PubMed

    Clark, Claire D; Dufton, Emily

    2015-02-01

    As President Jimmy Carter's advisor for health issues, Peter Bourne promoted a rational and comprehensive drug strategy that combined new supply-side efforts to prevent drug use with previously established demand-side addiction treatment programs. Using a public health ethic that allowed the impact of substances on overall population health to guide drug control, Bourne advocated for marijuana decriminalization as well as increased regulations for barbiturates. A hostile political climate, a series of rumors, and pressure from both drug legalizers and prohibitionists caused Bourne to resign in disgrace in 1978. We argue that Bourne's critics used his own public health framework to challenge him, describe the health critiques that contributed to Bourne's resignation, and present the story of his departure as a cautionary tale for today's drug policy reformers. PMID:25521893

  10. Common ground on surgical abortion?--engaging Peter Singer on the moral status of potential persons.

    PubMed

    Camosy, Charles C

    2008-12-01

    The debate over surgical abortion is certainly one of the most divisive in ethical discourse and for many it seems interminable. However, this paper argues that a primary reason for this is confusion with regard to what issues are actually under dispute. When looking at an entrenched and articulate figure on one side of the debate, Peter Singer, and comparing his views with those of his opponents, one finds that the disputed issue is actually quite a narrow one: the moral status of potential persons. Finding this common ground clears the conceptual space for a fruitful argument: the thesis of which is that most, including Singer, who argue that potential persons do not have full personal moral status fail to make the necessary distinction between natural potential (which confers moral status) and practical potential (which admittedly does not). PMID:19098134

  11. Sir Peter Medawar: science, creativity and the popularization of Karl Popper

    PubMed Central

    Calver, Neil

    2013-01-01

    Sir Peter Medawar was respected by scientists and literati alike. It was perhaps not surprising, then, that he would choose to involve himself in the ‘two cultures’ debate of 1959 and beyond. The focus of his intervention was the philosophy of Sir Karl Popper. However, Medawar's Popper was not the guru of falsification familiar from philosophy textbooks. Medawar's distinctive interpretation of Popper treated him instead as the source of insights into the role of creativity and imagination in scientific inquiry. This paper traces the context for Medawar's adoption of Popperian philosophy, together with its application before the debate. It then examines, within the context of the debate itself, the way in which Medawar attempted to reconcile scientific inquiry with literary practice. Medawar became increasingly convinced that not only was induction epistemologically unsound, but it was also damaging to the public role of the scientist. His construction of Popperianism would, he envisaged, provide a worthy alternative for scientists’ self-image.

  12. "The physician as poet" review of: Pereira, Peter Saying the World

    PubMed Central

    Weishaus, Joel

    2006-01-01

    Peter Pereira is a family physician and a poet. I weave excerpts from Dr. Pereira's poems into a brief history of medicine's mythological and historical roots, beginning with the Egyptian god Thoth, and the Greek physician Hippocrates. Along the way, I touch on the European Middle Ages and the Islamic World. Finally, I quote poet-critic T.S. Eliot, who was an early influence on Dr. Pereira's decision to become a poet, and contemporary physician-poets Rafael Campo and William Carlos Williams. I end by placing Dr. Pereira, whose practice is oriented toward immigrant families, in his indigenous Pacific Northwest, arguing that being both physician and poet helps Pereira to live in a world that is both intimately human and naturally impersonal.

  13. Dr. Peter Cavanaugh Explains the Need and Operation of the FOOT Experiment

    NASA Technical Reports Server (NTRS)

    2003-01-01

    This video clip is an interview with Dr. Peter Cavanaugh, principal investigator for the FOOT experiment. He explains the reasoning behind the experiment and shows some video clips of the FOOT experiment being calibrated and conducted in orbit. The heart of the FOOT experiment is an instrumented suit called the Lower Extremity Monitoring Suit (LEMS). This customized garment is a pair of Lycra cycling tights incorporating 20 carefully placed sensors and the associated wiring control units, and amplifiers. LEMS enables the electrical activity of the muscles, the angular motions of the hip, knee, and ankle joints, and the force under both feet to be measured continuously. Measurements are also made on the arm muscles. Information from the sensors can be recorded up to 14 hours on a small, wearable computer.

  14. Remelting and Remobilization in a Magmatic Arc: the St Peter Suite, South Australia

    NASA Astrophysics Data System (ADS)

    Symington, Neil; Weinberg, Roberto; Hasalová, Pavlina

    2014-05-01

    Thermo-mechanical models of magmatic arcs suggest that intermittent intrusion of magma batches should lead to remelting and remobilization of earlier intrusive rocks as a result of fluctuations in temperature and water content. However, examples of remelting and remobilization of earlier intrusive rocks, formed during arc-building, are surprisingly rare. We investigate the evolution of magmatic rocks of the Palaeoproterozoic St Peter Suite, in the Gawler Craton, South Australia. This suite records multiple intrusions, magma hybridization, and the remelting and remobilization of these intrusions to form migmatites and newly-formed leucocratic magmas. In this paper we detail first how multiple magma batches interact with one another as liquids and mushes during syn-magmatic deformation phases, and then detail the nature of migmatites resulting from anatexis of these same magmatic rocks and the resulting channel ways that allowed for magma remobilization. LA-ICP/MS U/Pb zircon dating yielded crystallization ages of 1647±12 Ma for an early diorite-to-granite suite, and 1604±12 Ma for a later magmatic suite of broadly similar composition. Both these suites underwent anatectic events. Titanite from late-formed leucosomes found within D2 shear zones in the older suite, yielded SHRIMP U/Pb age of 1605±7 Ma, within error of the age of the younger suite. We therefore infer that intrusion, crystallization and remelting/remobilization of this younger suite of rocks occurred within 10-15 M.yr. Thus, the St Peter Suite exposures record many of the key processes expected in arcs, including the prediction that early intrusive arc rocks remelt to form younger more fractionated magmas.

  15. Influence of depositional environment and diagenesis on gas reservoir properties in St. Peter Sandstone, Michigan basin

    SciTech Connect

    Harrison, W.B. III; Turmelle, T.M.; Barnes, D.A.

    1987-05-01

    The St. Peter Sandstone in the Michigan basin subsurface is rapidly becoming a major exploration target for natural gas. This reservoir was first proven with the successful completion of the Dart-Edwards 7-36 (Falmouth field, Missaukee County, Michigan) in 1981. Fifteen fields now are known, with a maximum of three producing wells in any one field. The production from these wells ranges from 1 to more than 10 MMCFGD on choke, with light-gravity condensate production of up to 450 b/d. Depth to the producing intervals ranges from about 7000 ft to more than 11,000 ft. The St. Peter Sandstone is an amalgamated stack of shoreface and shelf sequences more than 1100 ft in thickness in the basin center and thinning to zero at the basin margins. Sandstone composition varies from quartzarenite in the coarser sizes to subarkose and arkose in the finer sizes. Thin salty/shaly lithologies and dolomite-cemented sandstone intervals separate the porous sandstone packages. Two major lithofacies are recognized in the basin: a coarse-grained, well-sorted quartzarenite with various current laminations and a fine-grained, more poorly sorted subarkose and arkose with abundant bioturbation and distinct vertical and horizontal burrows. Reservoir quality is influenced by original depositional and diagenetic fabrics, but there is inversion of permeability and porosity with respect to primary textures in the major lithofacies. The initially highly porous and permeable, well-sorted, coarser facies is now tightly cemented with syntaxial quartz cement, resulting in a low-permeability, poor quality reservoir. The more poorly sorted, finer facies with initially lower permeabilities did not receive significant fluid flux until it passed below the zone of quartz cementation. This facies was cemented with carbonate which has subsequently dissolved to form a major secondary porosity reservoir.

  16. The Global Food Crisis: Causes and Solutions. Statement of Peter McPherson before the Senate Foreign Relations Committee

    ERIC Educational Resources Information Center

    National Association of State Universities and Land-Grant Colleges, 2008

    2008-01-01

    This paper presents Peter McPherson's statement before the Senate Foreign Relations Committee. He begins by saying that people have an immediate problem that must be addressed, hopefully in a way that does not complicate long-term solutions. They also have a long-term and more complicated agricultural problem that the world has neglected over many…

  17. Writing the True Self: Case Studies of Eng 101 Students Responding to a Peter Elbow-Inspired Curriculum

    ERIC Educational Resources Information Center

    Stansell, Jon W.

    2012-01-01

    My fulfillment in life comes through helping others develop their potential, work through their troubles, and follow their dreams. I have found that my college students embrace this aspect as I teach them expressive, author-involved writing. Peter Elbow's work asserts that this type of writing fits into his theory of personal development,…

  18. Communication; A Discussion at the Nobel Conference (5th, Gustavus Adolphus College, St. Peter, Minnesota, January 8-9, 1969).

    ERIC Educational Resources Information Center

    Roslansky, John D., Ed.

    This book consists of five lectures on communication given at the fifth Nobel Conference. Leroy G. Augenstein explores the positive and negative consequences of man's increasing capacity to manipulate and control the human mind. Peter Marler demonstrates that all the elements necessary for a communication system to qualify as a language exist…

  19. Serials Management in the Electronic Era: Papers in Honor of Peter Gellatly, Founding Editor of "The Serials Librarian."

    ERIC Educational Resources Information Center

    Cole, Jim, Ed.; Williams, James W., Ed.

    This book assesses progress and technical changes in the field of serials management and anticipates future directions and challenges for librarians. The book consists of 18 chapters: (1) "Introduction" (Jim Cole and James W. Williams); (2) "Peter Gellatly--Editor with a Deft Touch" (Ruth C. Carter); (3) "The "Deseret News" Web Edition" (Stewart…

  20. Peter Fensham--Head, Heart and Hands (on) in the Service of Science Education and Social Equity and Justice

    ERIC Educational Resources Information Center

    Gunstone, Richard

    2009-01-01

    When Peter Fensham was appointed to the new Chair of Science Education at Monash University in 1967 he was the first Professor of Science Education in Australia, and, we think, may well have been the first such professor anywhere in the world outside USA. Over the subsequent 40+ years he has made/still makes remarkable and diverse contributions to…

  1. Pratt & Whitney Advanced Ducted Propulsor (ADP) Engine Test in 40x80ft w.t.: Engineers Peter

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Pratt & Whitney Advanced Ducted Propulsor (ADP) Engine Test in 40x80ft w.t.: Engineers Peter Zell (left) and Dr Clifton Horne (right) are shown preparing a laser light sheet for a flow visualization test. Shown standing in the nacelle of the ADP is John Girvin, senior test engineer for Pratt & Whitney.

  2. 76 FR 13271 - Gulf & Ohio Railways, Inc., H. Peter Claussen and Linda C. Claussen-Continuance in Control...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... and published in the Federal Register (75 FR 63,533). The exemption became effective on October 31... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Gulf & Ohio Railways, Inc., H. Peter Claussen and Linda C....

  3. Teaching, Learning and Education in Late Modernity: The Selected Works of Peter Jarvis. World Library of Educationalists

    ERIC Educational Resources Information Center

    Jarvis, Peter

    2011-01-01

    Professor Peter Jarvis has spent over 30 years researching, thinking and writing about some of the key and enduring issues in education. He has contributed well over 30 books and 200 papers and chapters in books on learning theory, adult education and learning, continuing professional education, nurse education, primary school education, distance…

  4. Pratt & Whitney Advanced Ducted Propulsor (ADP) Engine Test in 40x80ft w.t.: Engineers Peter

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Pratt & Whitney Advanced Ducted Propulsor (ADP) Engine Test in 40x80ft w.t.: Engineers Peter Zell (left) and Dr Clifton Horne (right) are shown preparing for a laser light sheet for a flow visualization test. Shown standing in the nacelle of the ADP is John Girvin, senior test engineer for Pratt & Whitney.

  5. The Good, the Worthwhile and the Obligatory: Practical Reason and Moral Universalism in R. S. Peters' Conception of Education

    ERIC Educational Resources Information Center

    Martin, Christopher

    2009-01-01

    Peters' account of the moral life and the conception of practical reason that informed it reflects a sophisticated moral universalism. However, attempts to extend a similarly sophisticated universalism into our understanding of education are not as well received. Yet, such a project is of clear contemporary relevance given the pressure put on…

  6. A Dena'ina Legacy. K'tl'egh'i Sukdu. The Collected Writings of Peter Kalifornsky.

    ERIC Educational Resources Information Center

    Kalifornsky, Peter; Kari, James, Ed.; Boraas, Alan, Ed.

    This collection of writings was compiled over a 19-year period (1972-91) by the last writer and one of the last storytellers of the Kenai dialect of Dena'ina (Tanaina) language of Cook Inlet, Alaska. Peter Kalifornsky is a literary artist and scholar born in 1911. The 147 writings are organized in eight chapters, with a prelude containing two…

  7. Saving Time and Money in Michigan: Peter J. Young Talks about Professional Development, Parent Communication, Funding, and Partnerships

    ERIC Educational Resources Information Center

    Branzburg, Jeffrey

    2007-01-01

    This article presents an interview with Peter J. Young, Director of Technology at Rockford Public Schools in Michigan. In the interview, Young talked about how his district has done a lot more automation to integrate its disparate systems. He also discussed how they streamline their systems, how parents and community benefit from these efforts,…

  8. Utilization of the St. Peter Sandstone in the Illinois Basin for CO2 Sequestration

    SciTech Connect

    Will, Robert; Smith, Valerie; Leetaru, Hannes

    2014-09-30

    This project is part of a larger project co-funded by the United States Department of Energy (US DOE) under cooperative agreement DE-FE0002068 from 12/08/2009 through 9/31/2014. The study is to evaluate the potential of formations within the Cambro-Ordovician strata above the Mt. Simon Sandstone as potential targets for carbon dioxide (CO2) sequestration in the Illinois and Michigan Basins. This report evaluates the potential injectivity of the Ordovician St. Peter Sandstone. The evaluation of this formation was accomplished using wireline data, core data, pressure data, and seismic data acquired through funding in this project as well as existing data from two additional, separately funded projects: the US DOE funded Illinois Basin – Decatur Project (IBDP) being conducted by the Midwest Geological Sequestration Consortium (MGSC) in Macon County, Illinois, and the Illinois Industrial Carbon Capture and Sequestration (ICCS) Project funded through the American Recovery and Reinvestment Act (ARRA), which received a phase two award from DOE. This study addresses the question of whether or not the St. Peter Sandstone may serve as a suitable target for CO2 sequestration at locations within the Illinois Basin where it lies at greater depths (below the underground source of drinking water (USDW)) than at the IBDP site. The work performed included numerous improvements to the existing St. Peter reservoir model created in 2010. Model size and spatial resolution were increased resulting in a 3 fold increase in the number of model cells. Seismic data was utilized to inform spatial porosity distribution and an extensive core database was used to develop porosity-permeability relationships. The analysis involved a Base Model representative of the St. Peter at “in-situ” conditions, followed by the creation of two hypothetical models at in-situ + 1,000 feet (ft.) (300 m) and in-situ + 2,000 ft. (600 m) depths through systematic depthdependent adjustment of the Base Model

  9. HL-10 on lakebed with Jerauld R. Gentry, Peter Hoag, John A. Manke, and Bill Dana

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The four principal HL-10 pilots are seen here with the lifting body aircraft. They are, left to right; Air Force Major Jerauld R. Gentry, Air Force test pilot Peter Hoag, and NASA pilots John A. Manke and Bill Dana. All are wearing the pressure suits needed for flying above 50,000 feet. The HL-10 was one of five heavyweight lifting-body designs flown at NASA's Flight Research Center (FRC--later Dryden Flight Research Center), Edwards, California, from July 1966 to November 1975 to study and validate the concept of safely maneuvering and landing a low lift-over-drag vehicle designed for reentry from space. Northrop Corporation built the HL-10 and M2-F2, the first two of the fleet of 'heavy' lifting bodies flown by the NASA Flight Research Center. The contract for construction of the HL-10 and the M2-F2 was $1.8 million. 'HL' stands for horizontal landing, and '10' refers to the tenth design studied by engineers at NASA's Langley Research Center, Hampton, Va. After delivery to NASA in January 1966, the HL-10 made its first flight on Dec. 22, 1966, with research pilot Bruce Peterson in the cockpit. Although an XLR-11 rocket engine was installed in the vehicle, the first 11 drop flights from the B-52 launch aircraft were powerless glide flights to assess handling qualities, stability, and control. In the end, the HL-10 was judged to be the best handling of the three original heavy-weight lifting bodies (M2-F2/F3, HL-10, X-24A). The HL-10 was flown 37 times during the lifting body research program and logged the highest altitude and fastest speed in the Lifting Body program. On Feb. 18, 1970, Air Force test pilot Peter Hoag piloted the HL-10 to Mach 1.86 (1,228 mph). Nine days later, NASA pilot Bill Dana flew the vehicle to 90,030 feet, which became the highest altitude reached in the program. Some new and different lessons were learned through the successful flight testing of the HL-10. These lessons, when combined with information from it's sister ship, the M2-F2/F3

  10. Peter Andreas Hansen and the astronomical community - a first investigation of the Hansen papers. (German Title: Peter Andreas Hansen und die astronomische Gemeinschaft - eine erste Auswertung des Hansen-Nachlasses. )

    NASA Astrophysics Data System (ADS)

    Schwarz, Oliver; Strumpf, Manfred

    The literary assets of Peter Andreas Hansen are deposited in the Staatsarchiv Hamburg, the Forschungs- und Landesbibliothek Gotha and the Thüringer Staatsarchiv Gotha. They were never systematically investigated. We present here some results of a first evaluation. It was possible to reconstruct the historical events with regard to the maintenance of the Astronomische Nachrichten and the Altona observatory in 1854. Hansen was a successful teacher for many young astronomers. His way of stimulating the evolution of astronomy followed Zach's tradition.

  11. Controls on deposition of the St. Peter Sandstone (Middle-Late Ordovician), Michigan basin

    SciTech Connect

    Nadon, G.C.; Simo, A.; Byers, C.W.; Dott, R.H, Jr. )

    1991-08-01

    The St. Peter Sandstone (Middle-late Ordovician) of the Michigan basin represents an approximately 10-m.y. interval of clastic deposition in an otherwise carbonate-dominated Ordovician succession. This interval, up to 320 m thick, also coincides with a change in basin configuration from the nearly circular depocenter of the underlying Shakopee Formation to an east-west elongate trough situated west to Saginaw Bay. Interpretation of well logs and core from throughout the basin indicates that the clastics are composed of 20-25 sequences upper shoreface to tidal-flat environments. The sequences are interbedded with heavily bioturbated, shaly, lower shoreface sandstones (1-14 m thick) and, in the central and southeastern parts of the basin, with carbonate shales, stromatolites, and oolitic grain-stones (2-39 m thick). The eastern and southeastern margins of the basin contain the thickest carbonate accumulations. Hydrocarbons fields are located over structural highs formed by reactivation of basement structures. Detailed comparison of well logs within field shows that sedimentary cycles thin over the structures as a result of the local reduction in the formation of accommodation space by syndepositional movements on the faults. The presence of thick carbonates along the southeastern margin of the basin is a result of the combination of distance form the clastic source and the episodic formation of accommodation space by syndepositional normal faulting along the basin margin.

  12. Reminiscences of Sir Peter Medawar: in hope of antigen-specific transplantation tolerance.

    PubMed

    Simpson, Elizabeth

    2004-12-01

    Peter Medawar's career in medical research (he always described himself as a medical research scientist) began as a student of zoology in Oxford. He obtained a first class degree in 1936, aged 21, and undertook postgraduate studies with Florey. His work was anchored in a broad field; he was adept at addressing novel questions in the context of prior ideas and knowledge. His earlier interest in growth, driven as much by mathematics as biology, gave way to transplantation at the beginning of World War II, treatment of burns patients being the driver. He interpreted the results of grafting autologous and allogeneic human skin, observed clinically and microscopically, as immunological; he identified accelerated donor-specific reactions to subsequent grafts as 'second set', and described cell (lymphocyte) mediated infiltration of allo- but not auto-grafts following initial vascularization, both in the patient context and in experimental animals. He became intrigued by the consequences of hematopoietic chimerism, from which his landmark discoveries on the induction of transplantation tolerance derive. These results, his interpretation and dissemination of them, gave hope to transplant surgeons that donor-specific transplant tolerance would be achievable. Many immunosuppressive drugs later, we are now reapproaching this hope, from various angles. PMID:15575894

  13. Cold-Air-Pool Structure and Evolution in a Mountain Basin: Peter Sinks, Utah

    SciTech Connect

    Clements, Craig B.; Whiteman, Charles D.; Horel, John D.

    2003-06-01

    The evolution of potential temperature and wind structure during the buildup of nocturnal cold-air pools was investigated during clear, dry, September nights in Utah's Peter Sinks basin, a 1-km-diameter limestone sinkhole that holds the Utah minimum temperature record of -56 C. The evolution of cold-pool characteristics depended on the strength of prevailing flows above the basin. On an undisturbed day, a 30 C diurnal temperature range and a strong nocturnal potential temperature inversion (22 K in 100 m) were observed in the basin. Initially, downslope flows formed on the basin sidewalls. As a very strong potential temperature jump (17 K) developed at the top of the cold pool, however, the winds died within the basin and over the sidewalls. A persistent turbulent sublayer formed below the jump. Turbulent sensible heat flux on the basin floor became negligible shortly after sunset while the basin atmosphere continued to cool. Temperatures over the slopes, except for a 1 to 2-m-deep layer, became warmer than over the basin center at the same altitude. Cooling rates for the entire basin near sunset were comparable to the 90 W m-2 rate of loss of net longwave radiation at the basin floor, but these rates decreased to only a few watts per square meter by sunrise. This paper compares the observed cold-pool buildup in basins with inversion buildup in valleys.

  14. [Peter Plett and other discoverers of cowpox vaccination before Edward Jenner].

    PubMed

    Plett, Peter C

    2006-01-01

    Before Edward Jenner tested the possibility of using the cowpox vaccine as an immunisation for smallpox in humans in 1796, at least six people had done the same several years earlier. However, the findings of these six people regarding the cowpox vaccination are either hardly known or have even been forgotten. For the first time, the originally scattered information on the procedures used by these six people has been gathered and will be presented in this article. Detailed attention will be given to the works of the teacher Peter Plett (1766-1823), the only one to recognize the importance of his discovery for mankind. In 1790 and 1791/92, Plett reported his findings to the Medical Faculty of the University of Kiel. The faculty disregarded Plett's reports by neither responding to them nor changing their methods of immunisation, as the faculty at that time was still in favour of variolation. This article contains the available information and references concerning Plett's discovery, including the entire sources from 1802 and 1815 describing his findings. PMID:17338405

  15. Acute toxic effects of fenpyroximate acaricide on Guppy (Poecilia reticulata Peters, 1859).

    PubMed

    Doğan, Nesli; Yazıcı, Zehra; Şişman, Turgay; Aşkin, Hakan

    2013-09-01

    Fenpyroximate (FP), an acaricide, is widely used in the prevention of acarids (mites) in fruit plant gardens. In this study, the acute toxic effects of different concentrations of FP were investigated using adult guppy (Poecilia reticulata Peters, 1859). Guppy adults were exposed to a range of FP concentrations (25, 50, 75, 100, 125, and 150 µg/L) during 48 h. Static method, which is one of the acute toxicity experiments, has been used in this study. According to probit analysis, the 48-h median lethal concentration (LC50) value of FP at 26°C was found to be 72.821 µg/L. Sublethal exposures were predetermined based on 48-h LC50 value. Guppies were exposed to low concentrations (15, 25, and 50 µg/L) of FP for 48 h. Signs of paralysis and behavior deformations were monitored every 12 h in a number of live and dead adults. Low concentrations of FP were also responsible for erratic swimming, loss of equilibrium, and being lethargic. Liver histology revealed several pathological damages including congestion, picnotic nucleus, sinusoidal dilatation, increase in melanomacrophagic centers, and endothelial degeneration. Finally, the toxicity test results provided 48-h LC50 value for FP, and low concentrations of FP can be highly detrimental to guppy adults with clear evidence of behavioral and histologic effects. PMID:22508399

  16. "Pop" psychoanalysis, kitsch, and the "as if" theater: further notes on Peter Shaffer's Equus.

    PubMed

    Gifford, S

    1976-01-01

    This paper is intended as an examination of Dr. Stamm's (1975) paper and of Dr. Jules Glenn's discussion of Peter Shaffer's previous work. Its premise is the futility of subjecting Equus to a traditional psychoanalytic investigation, as a product of the playwright's unconscious, when the play represents a skillful, highly conscious use of analytic cliches to manipulate the audience. This phenomenon, however, and the play's great popularity prompt some reflections on the nature of kitsch, or false art, and its differences from authentic drama. The experience of kitsch can be identified when the spectator feels coerced by exaggerated, unconvincing theatrical devices, and fails to experience genuine empathy with the characters in a play. In the experience of authentic tragedy there is some element of voluntary surrender, of suspension of disbelief with full consent of will, as in the Aristotelian concept of catharsis. Shaffer's play is discussed as an illustration of this distinction and its relation to pseudoemotionality, the impostor syndrome, and the "as if" personality. In conclusion, the play's failure to evoke a genuine emotional response is explained by interpreting Equus as an "as if" tragedy. PMID:986375

  17. A psychoanalytic reading of Peter Høeg's novel Miss Smilla's Feeling for Snow.

    PubMed

    Gammelgaard, J

    2001-02-01

    The author presents a psychoanalytic reading of the Danish author Peter Høeg's masterpiece 'Miss Smilla's Feeling for Snow', focusing on the special linguistic style of the novel. Further, the author puts forward an interpretation of the heroine, seeing her as a literary example of female bisexuality. Investigating the heroine's fate, the author discusses Miss Smilla's phallic defence and identity. The narrative technique in Høeg's novel is analysed through Lacan's concepts of the Real, the Imaginary and the Symbolic. The main figure is interpreted as an imaginary example of female bisexuality. Miss Smilla has neither an unambiguous gender identity nor ethnicity. The heroine is pictured in a conflict between two cultures: the Greenlandish and the western European, and her bisexuality both reflects this and is part of it. The author proposes to interpret a significant memory from Smilla's early childhood as an example of a castration phantasy, which retroactively gives new significance to the little girl's pre-oedipal frustration. PMID:11234104

  18. [Catering services bases in the Russian army under military regulation of Peter the Great].

    PubMed

    Konyshev, I S; adamenko, A M; Koshelev, V P

    2014-01-01

    At Peter I the regular army was organized and the system of target state deliveries to troops of the food is created. Provisioning and fodder was normalized as portion and ration. Portion was contained the products forpeoplefood, and ration - fodder for horses food who were used by the serviceman. Portion and ration unit was identical to all categories of the military personnel. Difference in food level consisted in that, how many portions and rations serviceman received. Up to the end of existence of Russian army in 1918 in each rota there were contractor and the cook who were engaged in foodstuff and cooking under sergeant-major and one of rota officers supervision. According to the Charter it was necessary to carry with respect and attention to officers and soldiers, their needs, including in the field of supply and catering services and providing with the food: Despite the lack of scientific justification, soldiers' nutrition was sufficient to provide fighting capacity of the Russian army. PMID:25816632

  19. Peter Fensham—head, heart and hands (on) in the service of science education and social equity and justice

    NASA Astrophysics Data System (ADS)

    Gunstone, Richard

    2009-06-01

    When Peter Fensham was appointed to the new Chair of Science Education at Monash University in 1967 he was the first Professor of Science Education in Australia, and, we think, may well have been the first such professor anywhere in the world outside USA. Over the subsequent 40+ years he has made/still makes remarkable and diverse contributions to science education research and practice, both within Australia and internationally (in, it seems, every `corner' of the globe). As founder of ASERA and of science education research in Australia, Peter is clearly the most obvious and central Key Figure to include in this special issue of CSSE about the Australasian Science Education Research Association.

  20. Theoretical Claims Necessitate Basic Research: Reply to Gawronski, Lebel, Peters, and Banse (2009) and Nosek and Greenwald (2009)

    ERIC Educational Resources Information Center

    De Houwer, Jan; Teige-Mocigemba, Sarah; Spruyt, Adriaan; Moors, Agnes

    2009-01-01

    The authors of this reply article note that B. Gawronski, E. P. LeBel, K. R. Peters, and R. Banse (2009) (a) expressed agreement in their comment with the analysis put forward in the target article (J. De Houwer, S. Teige-Mocigemba, A. Spruyt, & A. Moors, 2009) and (b) pointed to a further implication for the way in which the implicitness of a…

  1. Wildlife and Wildlife Habitat Loss Assessment at Green Peter-Foster Project; Middle Fork Santiam River, Oregon, 1985 Final Report.

    SciTech Connect

    Noyes, J.H.

    1986-02-01

    A habitat based assessment was conducted of the US Army Corps of Engineers' Green Peter-Foster Dam and Reservoir Project on the Middle Fork Santiam River, Oregon, to determine losses or gains resulting from the development and operation of the hydroelectric related components of the project. Preconstruction, postconstruction, and recent vegetation cover types at the project site were mapped based on aerial photographs from 1955, 1972, and 1979, respectively. Vegetation cover types were identified within the affected area and acreages of each type at each period were determined. Eleven wildlife target species were selected to represent a cross-section of species groups affected by the project. An interagency team evaluated the suitability of the habitat to support the target species at each time period. An evaluation procedure which accounted for both the quantity and quality of habitat was used to aid in assessing impacts resulting from the project. The Green Peter-Foster Project extensively altered or affected 7873 acres of land and river in the Santiam River drainage. Impacts to wildlife centered around the loss of 1429 acres of grass-forb vegetation, 768 acres of shrubland, and 717 acres of open conifer forest cover types. Impacts resulting from the Green Peter-Foster Project included the loss of critical winter range for black-tailed deer and Roosevelt elk, and the loss of year-round habitat for deer, upland game birds, river otter, beaver, pileated woodpecker, and many other wildlife species. Bald eagle and osprey were benefited by an increase in foraging habitat. The potential of the affected area to support wildlife was greatly altered as a result of the Green Peter-Foster Project. Losses or gains in the potential of the habitat to support wildlife will exist over the life of the project.

  2. Two new species of quill mites (Acari: Syringophilidae) associated with the Chestnut-fronted Helmetshrike Prionops scopifrons (Peters) (Passeriformes: Vangidae) in Kenya.

    PubMed

    Klimovičová, Miroslava; Skoracki, Maciej; Hromada, Martin

    2016-01-01

    Two new species of syringophilid mites collected from Prionops scopifrons (Peters) (Passeriformes: Vangidae) in Kenya are described: Neoaulonastus prionops sp. nov. and Picobia meru sp. nov. They are the first syringophilid records from birds of the family Vangidae. PMID:27470747

  3. Chemical composition, antioxidant and antibacterial properties of Achillea collina Becker ex Heimerl s.l. and A. pannonica Scheele essential oils.

    PubMed

    Bozin, Biljana; Mimica-Dukic, Neda; Bogavac, Mirjana; Suvajdzic, Ljiljana; Simin, Natasa; Samojlik, Isidora; Couladis, Maria

    2008-01-01

    The in vitro antioxidant and antimicrobial activities of two Achillea millefolium (Adanson) Koch s.l species essential oils (A. collina Becker ex Heimerl s.l. and A. pannonica Scheele, Asteraceae) originating from the Golija and Radan mountains (Serbia) were investigated. The chemical profiles of the essential oils were evaluated by GC-MS. Antioxidant activity was assessed as free radical scavenging capacity (RSC) towards 2,2-diphenyl-1-picrylhydrazil (DPPH) radicals, together with effects on lipid peroxidation (LP). Antibacterial activity was examined on 21 bacterial strains. Based on the chemical composition of the essential oil, A. collina s.l. from Mount Golija was classified as a chamazulene chemotype (tetraploid). The high percentage of oxygenated monoterpenes and absence of azulene in the essential oil obtained from A. pannonica from Radan pointing that this population is octaploid. Essential oil of A. pannonica expressed stronger antimicrobial activity on almost all tested bacteria. Furthermore, this essential oil expressed higher scavenging effects on DPPH radical (IC(50) = 0.52 comparing to 0.62 mug/mL). Only in the LP evaluation, essential oil of A. collina s.l. from Golija exhibited stronger antioxidant activity (IC(50) = 0.75 comparing to 2.12 mug/mL). PMID:18830141

  4. Early Progressive Dilated Cardiomyopathy in a Family with Becker Muscular Dystrophy Related to a Novel Frameshift Mutation in the Dystrophin Gene Exon 27

    PubMed Central

    Tsuda, Takeshi; Fitzgerald, Kristi; Scavena, Mena; Gidding, Samuel; Cox, Mary O.; Marks, Harold; Flanigan, Kevin M.; Moore, Steven A.

    2014-01-01

    We report a family in which two male siblings with Becker muscular dystrophy (BMD) developed severe dilated cardiomyopathy (DCM) and progressive heart failure (HF) at age 11; one died at age 14 years while awaiting heart transplant and the other underwent left ventricular assist device (LVAD) implantation at the same age. Genetic analysis of one sibling showed a novel frameshift mutation in exon 27 of Duchenne muscular dystrophy (DMD) gene (c.3779_3785delCTTTGGAins GG), in which 7 base pairs are deleted and two are inserted. While this predicts an amino acid substitution and premature termination (p.Thr1260Argfs*8), muscle biopsy dystrophin immunostaining instead indicates that the mutation is more likely to alter splicing. Despite relatively preserved skeletal muscular performance, both siblings developed progressive heart failure secondary to early onset DCM. In addition, their 7 year old nephew with delayed gross motor development, mild proximal muscle weakness, and markedly elevated serum creatine kinase (CK) level (> 13,000 IU/L) at 16 months was recently demonstrated to have the familial DMD mutation. Here we report a novel genotype of BMD with early onset DCM and progressive lethal heart failure during early adolescence. PMID:25537791

  5. Screening Duchenne and Becker muscular dystrophy patients for deletions in 30 exons of the dystrophin gene by three-multiplex PCR

    SciTech Connect

    Risch, N. )

    1992-09-01

    Deletion mutations of the dystrophin gene may cause either the severe Duchenne muscular dystrophy (DMD) or the milder, allelic Becker muscular dystrophy (BMD) and are clustered in two high-frequency-deletion regions (HFDRs) located, respectively, 500 kb and 1,200 kb downstream from the 5[prime] end of the gene. Three PCR reactions described allowed the analysis of a total of 30 exons and led, to the identification of three additional deletions involving the following exons: (a) 42 only, (b) 28-42, and (c) 16 only, none of which were detected with the two original multiplex reactions. Therefore, the three modified multiplexes detected 95 of the 96 deletions identified among the 152 patients studied so far by using Southern analysis and cDNA probes. The only deletion that remained undetected with this system involves exons 22-25 and generates the junction fragment described elsewhere. The percentage of deletion mutations among DMS/BMD patients amounts to 63%, which is in agreement with similar estimates from other laboratories. When field-inversion gel electrophoresis is coupled to Southern analysis, the detection rate of deletion and duplication mutations reaches 65%.

  6. A dissection of the chapter "Tools for Research" in Peter Singer's Animal Liberation.

    PubMed

    Russell, S M; Nicoll, C S

    1996-02-01

    The book Animal Liberation, by philosopher Peter Singer, is frequently referred to as the bible of the animal liberation/rights movement(ALARM). Thus, Singer is regarded as a major moral standard-bearer of the ALARM. Some have suggested that his book provides "intellectual rigor" to the moral arguments for animals' equality with humans, which had previously been based largely on emotionalism and sentimentality. We have analyzed the contents of the chapter "Tools for Research" which criticizes the use of animals in biomedical research as well as for drug and product-safety testing. In order to discredit these practices, Singer "documents" his arguments with 138 "notes", some of which are to the same reference and others of which contain multiple references. Of the 132 difference references, we attempted to verify the accuracy of 49 of them. Of these, 16 (33%) were inaccurate or we could not find. In addition, Singer mischaracterizes the cited studies in various ways. He quotes selectively and out of context from numerous research projects. He never mentions the objectives of these projects, except occasionally when, in our opinion, he distorts or trivializes them. Singer also cites supposedly damning "evidence" published by other antivivisectionists, even though this "evidence" has been refuted in the literature. Singer supposedly embraces utilitarianism, a philosophy which holds that the harm done by a practice should be balanced against the gain realized from it. However, he makes virtually no attempt to consider objectively the benefits that have been realized from animal-based medical research and he greatly exaggerates the costs. To him, animal research is "all pain and no gain." We believe that Singer's moral arguments for animal equality are not convincing. The lack of objectivity and the reliance upon distortion and selective quotation that characterize Singer's "scholarship" are surprising when one considers that he presents himself as an ethicist and

  7. Geochemistry of dolomites in the St. Peter Sandstone of the Michigan Basin

    SciTech Connect

    Winter, B.L.; Johnson, C.M.; Valley, J.W. . Dept. of Geology and Geophysics)

    1992-01-01

    Quartz sandstone units in mid-continent sedimentary basins are considered to be major migration pathways for fluids throughout the history of such basins, possibly including connate and meteoric water, hydrocarbons, evaporite and basinal brines, and MVT ore-forming fluids. To gain an understanding of the fluid history of the Michigan Basin, the authors are investigating the dolomites in the St. Peter Sandstone. Based on petrography and lithofacies occurrence, they categorize the dolomites as: dolomite cement in quartz sandstone (DCS), replacive dolomite in carbonate-dominated intervals (RD), and fracture fill dolomite (FFD) associated with RD. RD and FFD display a linear covariation of mole %FeCO[sub 3] and Mn with Fe/Mn ratios increasing from 6 for bright orange luminescent RD to 11 for non-luminescent FFD. DCS display the highest %FeCO[sub 3] and no Fe-Mn correlation. DCS have higher ratios and SR concentrations than RD and FFD. Data for RD and FFD define two different, linear positive-sloping, Sr-87/Sr-86-%FeCO[sub 3] covariation trends. Samples with higher ratios and %FeCO[sub 3] have systematically lower [delta] O-18 values. Dolomites with Sr < 130ppm (mostly RD and FFD) follow the Sr-%MgCO[sub 3] trend defined by modern seawater dolomites; most of the DCS plot above this seawater dolomite trend. These data suggest that the RD and FFD precipitated from mid-Paleozoic seawater that progressively evolved in a basinal setting or mixed with an evolved basinal brine. DCS precipitated from a basinal brine that had interacted with rocks containing a significant amount of K-feldspar. The different correlation trends suggest heterogeneous water-rock interaction and isolated flow paths.

  8. Peters plus syndrome mutations disrupt a non-canonical ER quality control mechanism

    PubMed Central

    Vasudevan, Deepika; Takeuchi, Hideyuki; Johar, Sumreet Singh; Majerus, Elaine; Haltiwanger, Robert S.

    2014-01-01

    Background O-Fucose is added to cysteine-rich domains called Thrombospondin type 1 repeats (TSRs) by Protein O-fucosyltransferase 2 (POFUT2) and is elongated with glucose by β3-glucosyltransferase (B3GLCT). Mutations in B3GLCT result in Peters Plus Syndrome (PPS), an autosomal recessive disorder characterized by eye and other developmental defects. Although 49 putative targets are known, the function of the disaccharide and its role in PPS remain unexplored. Results Here we show that while POFUT2 is required for secretion of all targets tested, B3GLCT only affects the secretion of a subset, consistent with the observation that B3GLCT mutant phenotypes in PPS patients are less severe than embryonic lethal phenotypes of Pofut2-null mice. O-Glycosylation occurs co-translationally, as TSRs fold. Mass spectral analysis reveals that TSRs from mature, secreted protein are stoichiometrically modified with the disaccharide, while TSRs from protein still folding in the ER are partially modified, suggesting that O-glycosylation marks folded TSRs and promotes ER exit. In vitro unfolding assays demonstrate that fucose and glucose stabilize folded TSRs in an additive manner. In vitro refolding assays under redox conditions showed that POFUT2 recognizes, glycosylates, and stabilizes the folded form of TSRs, resulting in a net acceleration of folding. Conclusions While known ER quality control machinery rely on identifying and tagging unfolded proteins, we find that POFUT2 and B3GLCT mediate a non-canonical ER quality control mechanism that recognizes folded TSRs and stabilizes them by glycosylation. Our findings provide a molecular basis for the defects observed in PPS and potential targets that contribute to the pathology. PMID:25544610

  9. The 2007 Nobel Prize in Physics: Albert Fert and Peter Grünberg

    NASA Astrophysics Data System (ADS)

    Cros, Vincent; Fert, Albert; Sénéor, Pierre; Petroff, Frédéric

    GMR and spintronics take their roots in the pioneering work of Albert Fert around 1970 on the influence of the spin on the mobility of electrons in ferromagnetic materials [1]. After having experimentally demonstrated that, in a ferromagnetic metal, the electrons of opposite spin directions (spin up and spin down along the magnetization axis) carry different currents (as originally suggested by Mott), Fert worked out the well known two current model of the electrical conduction in ferromagnetic metals. He also showed that very large spin asymmetries of the conduction can be obtained by doping the ferromagnetic metal with impurities selected to scatter very differently the spin up and spin down electrons (iron or cobalt impurities in nickel, for example, scatter the spin down electrons 20 times more strongly than the spin up electrons). Moreover, some experiments of Fert on ternary alloys were already introducing the idea that he will exploit later to produce the GMR effects. He showed that the resistivity of a ternary alloy, for example N 1-x (A x-y ,B y ), is strongly enhanced if the scattering by the impurities A and B have inverse spin asymmetries. Replacing the impurities A and B by magnetic layers A and B, one equally expects a large enhancement of the resistivity when their magnetizations are in opposite directions, which the basic concept of the GMR. However, this concept can work only if the thickness of the layers is in the nanometer range. The fabrication of multilayers with thicknesses in this range became technologically possible in the mid-eighties and, in particular, the growth of magnetic multilayers by Molecular Beam Epitaxy (MBE) was developed in the groups of Albert Fert and Peter Grünberg.

  10. The 6-minute walk test, motor function measure and quantitative thigh muscle MRI in Becker muscular dystrophy: A cross-sectional study.

    PubMed

    Fischer, Dirk; Hafner, Patricia; Rubino, Daniela; Schmid, Maurice; Neuhaus, Cornelia; Jung, Hans; Bieri, Oliver; Haas, Tanja; Gloor, Monika; Fischmann, Arne; Bonati, Ulrike

    2016-07-01

    Becker muscular dystrophy (BMD) has an incidence of 1 in 16 000 male births. This cross-sectional study investigated the relation between validated functional scores and quantitative MRI (qMRI) of thigh muscles in 20 ambulatory BMD patients, aged 18.3-60 years (mean 31.2; SD 11.1). Clinical assessments included the motor function measure (MFM) and its subscales, as well as timed function tests such as the 6-minute walk test (6MWT) and the timed 10-m run/walk test. Quantitative MRI of the thigh muscles included the mean fat fraction (MFF) using a 2-point Dixon (2-PD) technique, and transverse relaxation time (T2) measurements. The mean MFM value was 80.4%, SD 9.44 and the D1 subscore 54.5%, SD 19.9. The median 6MWT was 195m, IQR 160-330.2. The median 10-m run/walk test was 7.4 seconds, IQR 6.1-9.3. The mean fat fraction of the thigh muscles was 55.6%, SD 17.4%, mean T2 relaxation times of all muscles: 69.9 ms, SD 14.4. The flexors had the highest MFF and T2 relaxation times, followed by the extensors and the adductors. MFF and global T2 relaxation times were highly negatively correlated with the MFM total, D1-subscore and 6MWT, and positively correlated with the 10 m run/walk test time (p < 0.01). Age was not correlated with MFF, global T2 relaxation time or clinical assessments. Both MFF and T2 measures in the thigh muscle were well correlated with clinical function in BMD and may serve as a surrogate outcome measure in clinical trials. PMID:27209345

  11. A new Lagerstätte from the Middle Ordovician St. Peter Formation in northeast Iowa, USA

    NASA Astrophysics Data System (ADS)

    Liu, Huaibao P.; McKay, Robert M.; Young, Jean N.; Witzke, Brian J.; McVey, Kathlyn J.; Liu, Xiuying

    2006-11-01

    A new fossil fauna has been discovered from a recently recognized shale unit within the middle Ordovician St. Peter Formation in northeast Iowa. It contains a variety of invertebrates and vertebrates, including soft body tissues, impressions, and 3-dimensionalpreservations. The exceptional preservation reveals a new Konservat-Lagerstätte, the Winneshiek Lagerstätte, and opens a unique window into the community that inhabited the margins of the Laurentian cratonic seaway during Middle Ordovician transgression. Among the fossils, several conodont assemblages, including the apparatus of enigmatic coleodontids, are preserved. Some conodont assemblages associated with soft body tissues are particularly noteworthy.

  12. A new Lagerstätte from the Middle Ordovician St. Peter formation in northeast Iowa, USA

    USGS Publications Warehouse

    Liu, Huaibao P.; McKay, Robert M.; Young, Jean N.; Witzke, Brian J.; McVey, Kathlyn J.; Liu, Xiuying

    2006-01-01

    A new fossil fauna has been discovered from a recently recognized shale unit within the middle Ordovician St. Peter Formation in northeast Iowa. It contains a variety of invertebrates and vertebrates, including soft body tissues, impressions, and 3-dimensionalpreservations. The exceptional preservation reveals a new Konservat-Lagerstätte, the Winneshiek Lagerstätte, and opens a unique window into the community that inhabited the margins of the Laurentian cratonic seaway during Middle Ordovician transgression. Among the fossils, several conodont assemblages, including the apparatus of enigmatic coleodontids, are preserved. Some conodont assemblages associated with soft body tissues are particularly noteworthy.

  13. An Efficient Image Encryption Scheme Based on a Peter De Jong Chaotic Map and a RC4 Stream Cipher

    NASA Astrophysics Data System (ADS)

    Hanchinamani, Gururaj; Kulkarni, Linganagouda

    2015-09-01

    Security is a vital issue in communication and storage of the images and encryption is one of the ways to ensure the security. This paper proposes an efficient image encryption scheme based on a Peter De Jong chaotic map and a RC4 stream cipher. A Peter De Jong map is employed to determine the initial keys for the RC4 stream generator and also during permutation stage. The RC4 stream generator is utilized to generate the pseudo random numbers for the pixel value rotation and diffusion operations. Each encryption round is comprised of three stages: permutation, pixel value rotation and diffusion. The permutation is based on scrambling the rows and columns, in addition, circular rotations of the rows and columns in alternate orientations. The second stage circularly rotates each and every pixel value by utilizing M × N pseudo random numbers. The last stage carries out the diffusion twice by scanning the image in two different ways. Each of the two diffusions accomplishes the diffusion in two orientations (forward and backward) with two previously diffused pixels and two pseudo random numbers. The security and performance of the proposed method is assessed thoroughly by using key space, statistical, differential, entropy and performance analysis. Moreover, two rounds of the call to the encrypt function provide the sufficient security. The experimental results show that the proposed encryption scheme is computationally fast with high security.

  14. A novel point mutation (G-1 to T) in a 5' splice donor site of intron 13 of the dystrophin gene results in exon skipping and is responsible for Becker muscular dystrophy.

    PubMed Central

    Hagiwara, Y.; Nishio, H.; Kitoh, Y.; Takeshima, Y.; Narita, N.; Wada, H.; Yokoyama, M.; Nakamura, H.; Matsuo, M.

    1994-01-01

    The mutations in one-third of Duchenne and Becker muscular dystrophy patients remain unknown, as they do not involve gross rearrangements of the dystrophin gene. We now report a defect in the splicing of precursor mRNA (pre-mRNA), resulting from a maternally inherited mutation of the dystrophin gene in a patient with Becker muscular dystrophy. This defect results from a G-to-T transversion at the terminal nucleotide of exon 13, within the 5' splice site of intron 13, and causes complete skipping of exon 13 during processing of dystrophin pre-mRNA. The predicted polypeptide encoded by the aberrant mRNA is a truncated dystrophin lacking 40 amino acids from the amino-proximal end of the rod domain. This is the first report of an intraexon point mutation that completely inactivates a 5' splice donor site in dystrophin pre-mRNA. Analysis of the genomic context of the G-1-to-T mutation at the 5' splice site supports the exon-definition model of pre-mRNA splicing and contributes to the understanding of splice-site selection. Images Figure 2 Figure 5 PMID:8279470

  15. A novel point mutation (G-1 to T) in a 5' splice donor site of intron 13 of the dystrophin gene results in exon skipping and is responsible for Becker muscular dystrophy.

    PubMed

    Hagiwara, Y; Nishio, H; Kitoh, Y; Takeshima, Y; Narita, N; Wada, H; Yokoyama, M; Nakamura, H; Matsuo, M

    1994-01-01

    The mutations in one-third of Duchenne and Becker muscular dystrophy patients remain unknown, as they do not involve gross rearrangements of the dystrophin gene. We now report a defect in the splicing of precursor mRNA (pre-mRNA), resulting from a maternally inherited mutation of the dystrophin gene in a patient with Becker muscular dystrophy. This defect results from a G-to-T transversion at the terminal nucleotide of exon 13, within the 5' splice site of intron 13, and causes complete skipping of exon 13 during processing of dystrophin pre-mRNA. The predicted polypeptide encoded by the aberrant mRNA is a truncated dystrophin lacking 40 amino acids from the amino-proximal end of the rod domain. This is the first report of an intraexon point mutation that completely inactivates a 5' splice donor site in dystrophin pre-mRNA. Analysis of the genomic context of the G-1-to-T mutation at the 5' splice site supports the exon-definition model of pre-mRNA splicing and contributes to the understanding of splice-site selection. PMID:8279470

  16. A novel point mutation (G[sup [minus]1] to T) in a 5[prime] splice donor site of intron 13 of the dystrophin gene results in exon skipping and is responsible for Becker Muscular Dystrophy

    SciTech Connect

    Hagiwara, Yoko; Nishio, Hisahide; Kitoh, Yoshihiko; Takeshima, Yasuhiro; Narita, Naoko; Wada, Hiroko; Yokoyama, Mitsuhiro; Nakamura, Hajime; Matsuo, Masafumi )

    1994-01-01

    The mutations in one-third of Duchenne and Becker muscular dystrophy patients remain unknown, as they do not involve gross rearrangements of the dystrophin gene. The authors now report a defect in the splicing of precursor mRNA (pre-mRNA), resulting from a maternally inherited mutation of the dystrophin gene in a patient with Becker muscular dystrophy. This defect results from a G-to-T transversion at the terminal nucleotide of exon 13, within the 5[prime] splice site of intron 13, and causes complete skipping of exon 13 during processing of dystrophin pre-mRNA. The predicted polypeptide encoded by the aberrant mRNA is a truncated dystrophin lacking 40 amino acids from the amino-proximal end of the rod domain. This is the first report of an intraexon point mutation that completely inactivates a 5[prime] splice donor site in dystrophin pre-mRNA. Analysis of the genomic context of the G[sup [minus]1]-to-T mutation at the 5[prime] splice site supports the exon-definition model of pre-mRNA splicing and contributes to the understanding of splice-site selection. 48 refs., 5 figs.

  17. Duchenne and Becker Muscular Dystrophies

    MedlinePlus

    ... a cardiac evaluation. Physical and occupational therapy A physical therapy program is usually part of the treatment for ... evalua- tion and recommendations. The primary goals of physical therapy are to allow greater motion in the joints ...

  18. Gary Becker: Model Economic Scientist

    PubMed Central

    2015-01-01

    This paper presents Gary Becker’s approach to conducting creative, empirically fruitful economic research. It describes the traits and methodology that made him such a productive and influential scholar. PMID:26705367

  19. Biology of Grapsus grapsus (L innaeus, 1758) (Brachyura, Grapsidae) in the Saint Peter and Saint Paul Archipelago, Equatorial Atlantic Ocean

    NASA Astrophysics Data System (ADS)

    Freire, A. S.; Pinheiro, M. A. A.; Karam-Silva, H.; Teschima, M. M.

    2011-09-01

    Eleven expeditions were undertaken to the Saint Peter and Saint Paul Archipelago to study the reproductive biology of Grapsus grapsus, providing additional information on limb mutilation and carapace colour. MATURE software was used to estimate morphological maturity, while gonadal analyses were conducted to estimate physiological maturity. The puberty moult took place at larger size in males (51.4 mm of carapace length) than in females (33.8 mm), while physiological maturity occurred at a similar size in males (38.4 mm) and in females (33.4 mm). Above 50 mm, the proportion of red males increased in the population, indicating that functional maturity is also related to colour pattern. Small habitat and high local population density contributed to the high rate of cannibalism. The low diversity of food items, absence of predators of large crabs and high geographic isolation are the determinants of unique behavioural and biological characteristics observed in the G. grapsus population.

  20. Potential metabolic strategies of widely distributed holobionts in the oceanic archipelago of St Peter and St Paul (Brazil).

    PubMed

    Rua, Cintia P J; Gregoracci, Gustavo B; Santos, Eidy O; Soares, Ana Carolina; Francini-Filho, Ronaldo B; Thompson, Fabiano

    2015-06-01

    Sponges are one of the most complex symbiotic communities and while the taxonomic composition of associated microbes has been determined, the biggest challenge now is to uncover their functional role in symbiosis. We investigated the microbiota of two widely distributed sponge species, regarding both their taxonomic composition and their functional roles. Samples of Didiscus oxeata and Scopalina ruetzleri were collected in the oceanic archipelago of St Peter and St Paul and analysed through metagenomics. Sequences generated by 454 pyrosequencing and Ion Torrent were taxonomically and functionally annotated on the MG-RAST server using the GenBank and SEED databases, respectively. Both communities exhibit equivalence in core functions, interestingly played by the most abundant taxa in each community. Conversely, the microbial communities differ in composition, taxonomic diversity and potential metabolic strategies. Functional annotation indirectly suggests differences in preferential pathways of carbon, nitrogen and sulphur metabolisms, which may indicate different metabolic strategies. PMID:25873456

  1. Occurrences of whale shark (Rhincodon typus Smith, 1828) in the Saint Peter and Saint Paul archipelago, Brazil.

    PubMed

    Hazin, F H V; Vaske Júnior, T; Oliveira, P G; Macena, B C L; Carvalho, F

    2008-05-01

    The Saint Peter and Saint Paul Archipelago in the central tropical Atlantic, is an important ground of whale sharks that are commonly sighted throughout the year close to the fishing boats in the adjacencies of the islands. In sightings reported between February 2000 and November 2005, the lengths of the individuals ranged between 1.8 to 14.0 m. The causes of these concentrations in the archipelago are still unclear, once there are no upwellings and plankton concentrations for feeding, and no reproductive activities were reported. Nevertheless, they could be associated to the spawning period of the abundant flying fishes, mainly in the first semester, when sightings were more frequent. PMID:18660968

  2. The impact of implanted whale carcass on nematode communities in shallow water area of Peter the Great Bay (East Sea)

    NASA Astrophysics Data System (ADS)

    Pavlyuk, Olga N.; Trebukhova, Yulia A.; Tarasov, Vitalyi G.

    2009-09-01

    In May, 2007 we sank the remains of a Minke whale ( Balaenoptera acutorostrata) in the East Sea, Peter the Great Bay, at 30 m of water near the coast of Big Pelis Island. In the present study we describe the nematode communities in sediments under the implanted whale carcass. Abundance of nematodes increased with the distance from the carcass. Dominant trophic group was non-selective deposit feeders. The highest values of indexes of a specific diversity and evenness were noted in sediments under the whale, while domination index occurred at the highest distance from the whale. The suggestion is made that the cause of low density of nematodes in sediments under the whale is an extreme increase in number of macrofaunal animals, and predation and food competition between macro- and meiofauna. The changes noted in nematode assemblages living in an implanted whale in shallow waters are similar to those in deep-sea assemblages.

  3. Some Practices and Approaches Are Clearly Better than Others and We Had Better Not Ignore the Differences. A Response to Peter Smagorinsky

    ERIC Educational Resources Information Center

    Hillocks, George, Jr.

    2009-01-01

    Professor Peter Smagorinsky argues that it is time teachers gave up on the idea of best practice in the teaching of English, and the author tends to agree. At the same time, the author differs on certain points. Smagorinsky's premise is based on the idea that all teacher practices have been enculturated through the various experiences, people, and…

  4. Peter Magolda's Proposal for an Unholy Alliance: Cautions and Considerations regarding Collaboration between Student Affairs and Faith-Based Student Organizations

    ERIC Educational Resources Information Center

    Glanzer, Perry L.

    2011-01-01

    In a recent volume of the "Journal of College and Character", Peter Magolda (2010) suggested that student administration professionals and campus religious groups should strive to overcome the separation that has been observed between the groups. In the present article, the author contends that good historical, moral, and legal reasons remain for…

  5. Pattern of deletions of the dystrophin gene in Mexican Duchenne/Becker muscular dystrophy patients: the use of new designed primers for the analysis of the major deletion "hot spot" region.

    PubMed

    Coral-Vazquez, R; Arenas, D; Cisneros, B; Peñaloza, L; Salamanca, F; Kofman, S; Mercado, R; Montañez, C

    1997-06-13

    We have analyzed 59 unrelated Mexican Duchenne/Becker muscular dystrophy patients (DMD/BMD) using PCR analysis of the 2 prone deletion regions in the DMD gene. Thirty one (52%) of the patients had a deletion of one or several of the exons. Most of the alterations (87%) were clustered in exons 44-52, this being the highest percentage reported until now. In order to improve the molecular diagnosis in the Mexican population, we designed a new multiplex assay to PCR amplify exons 44-52. This assay allowed for the identification of a greater number of deletions in this region compared with the 9 and 5-plex assays previously described and to determine most of the deletion end boundaries. This is a reliable alternative for the initial screening of the DMD patients in the Mexican population. PMID:9188659

  6. Geological Carbon Sequestration Storage Resource Estimates for the Ordovician St. Peter Sandstone, Illinois and Michigan Basins, USA

    SciTech Connect

    Barnes, David; Ellett, Kevin; Leetaru, Hannes

    2014-09-30

    The Cambro-Ordovician strata of the Midwest of the United States is a primary target for potential geological storage of CO2 in deep saline formations. The objective of this project is to develop a comprehensive evaluation of the Cambro-Ordovician strata in the Illinois and Michigan Basins above the basal Mount Simon Sandstone since the Mount Simon is the subject of other investigations including a demonstration-scale injection at the Illinois Basin Decatur Project. The primary reservoir targets investigated in this study are the middle Ordovician St Peter Sandstone and the late Cambrian to early Ordovician Knox Group carbonates. The topic of this report is a regional-scale evaluation of the geologic storage resource potential of the St Peter Sandstone in both the Illinois and Michigan Basins. Multiple deterministic-based approaches were used in conjunction with the probabilistic-based storage efficiency factors published in the DOE methodology to estimate the carbon storage resource of the formation. Extensive data sets of core analyses and wireline logs were compiled to develop the necessary inputs for volumetric calculations. Results demonstrate how the range in uncertainty of storage resource estimates varies as a function of data availability and quality, and the underlying assumptions used in the different approaches. In the simplest approach, storage resource estimates were calculated from mapping the gross thickness of the formation and applying a single estimate of the effective mean porosity of the formation. Results from this approach led to storage resource estimates ranging from 3.3 to 35.1 Gt in the Michigan Basin, and 1.0 to 11.0 Gt in the Illinois Basin at the P10 and P90 probability level, respectively. The second approach involved consideration of the diagenetic history of the formation throughout the two basins and used depth-dependent functions of porosity to derive a more realistic spatially variable model of porosity rather than applying a

  7. Geologic and Geophysicsal Studies of Natural Hazards and Risks in the Gulf of Peter the Great, Japan Sea

    NASA Astrophysics Data System (ADS)

    Anokhin, Vladimir; Shcherbakov, Viktor; Motychko, Viktor; Slinchenkov, Vladimir; Sokolov, Georgy; Kotov, Sergey; Kartashov, Sergey

    2013-04-01

    The area of the Gulf of Peter the Great is socially, economically and culturally one of the most important regions for the Russian Far East. At the same time, there have been reported palpable natural hazards, which pose a real threat to local infrastructure. Complex field team of the Gramaberg VNIIOkeangeologia institute carried out geological and geophysical studies of natural hazards in the water area and coastal zone of the gulf in the summer and autumn of 2012. The research program included - geodetic deformation monitoring of the coastal zone by the HDS 3000 Leica tachometer; - echo sounding of the underwater part of the coastal slope by the LCX-37C depth sounder equipped with active external 12-channel GPS Lowrance antenna LGC-3000; - high-frequency acoustic profiling by GeoPulse Subbotom Profilier with oscillator frequency of 12.2 kHz for the study of bottom sediments to a depth of 40 m; - hydromagnetic measurements by SeaSPY Marine Magnetics magnetometer for investigation of deep geological structure; - sonar measurements by GEO SM C-MAX, 325 kHz frequency emitters for studying seafloor features; - studies of the water column (sensing and sampling); - bottom sediment sampling. Analytic work was performed by mass spectrometry, atomic absorption spectrophotometry, chromatography, gas chromatography-mass spectrometry, gamma spectrometry and included the following. For water - the content of Fe, Mn, Cd, As, Pb, Cu, Co, Ni, Cr, Zn, Hg in solution and in suspension, polycyclic aromatic compounds, organochlorine pesticides, oil, methane. For sediments - grade analysis, mineralogical analysis of sand, determination of Fe, Mn, Cd, As, Pb, Cu, Co, Ni, Cr, Zn, Hg content; identification of petroleum products, polychlorinated biphenyls, organochlorine pesticides, the specific activity of Cs-137. As a result, a set of geological maps was composed: maps of pre-Quaternary and Quaternary rocks and deposits, lithological map, geomorphological map, map of engineering

  8. Cato Guldberg and Peter Waage, the history of the Law of Mass Action, and its relevance to clinical pharmacology.

    PubMed

    Ferner, Robin E; Aronson, Jeffrey K

    2016-01-01

    We have traced the historical link between the Law of Mass Action and clinical pharmacology. The Law evolved from the work of the French chemist Claude Louis Berthollet, was first formulated by Cato Guldberg and Peter Waage in 1864 and later clarified by the Dutch chemist Jacobus van 't Hoff in 1877. It has profoundly influenced our qualitative and quantitative understanding of a number of physiological and pharmacological phenomena. According to the Law of Mass Action, the velocity of a chemical reaction depends on the concentrations of the reactants. At equilibrium the concentrations of the chemicals involved bear a constant relation to each other, described by the equilibrium constant, K. The Law of Mass Action is relevant to various physiological and pharmacological concepts, including concentration-effect curves, dose-response curves, and ligand-receptor binding curves, all of which are important in describing the pharmacological actions of medications, the Langmuir adsorption isotherm, which describes the binding of medications to proteins, activation curves for transmembrane ion transport, enzyme inhibition and the Henderson-Hasselbalch equation, which describes the relation between pH, as a measure of acidity and the concentrations of the contributory acids and bases. Guldberg and Waage recognized the importance of dynamic equilibrium, while others failed to do so. Their ideas, over 150 years old, are embedded in and still relevant to clinical pharmacology. Here we explain the ideas and in a subsequent paper show how they are relevant to understanding adverse drug reactions. PMID:26174880

  9. Mesophotic reef fish assemblages of the remote St. Peter and St. Paul's Archipelago, Mid-Atlantic Ridge, Brazil

    NASA Astrophysics Data System (ADS)

    Rosa, Marcos Rogerio; Alves, Aline Cristina; Medeiros, Diego Valverde; Coni, Ericka Oliveira Cavalcanti; Ferreira, Camilo Moitinho; Ferreira, Beatrice Padovani; de Souza Rosa, Ricardo; Amado-Filho, Gilberto Menezes; Pereira-Filho, Guilherme Henrique; de Moura, Rodrigo Leão; Thompson, Fabiano Lopes; Sumida, Paulo Yukio Gomes; Francini-Filho, Ronaldo Bastos

    2016-03-01

    Mesophotic reef fish assemblages (30-90 m depth) of the small and remote St. Peter and St. Paul's Archipelago (SPSPA), Mid-Atlantic Ridge, Brazil, were characterized using remotely operated vehicles. Ordination analyses identified distinct fish assemblages in the upper (30-50 m) and lower (50-90 m) mesophotic zones, the former characterized by high abundances of species that are also abundant at euphotic reefs ( Caranx lugubris, Melichthys niger, Stegastes sanctipauli and Chromis multilineata) and the latter dominated by two mesophotic specialists ( Prognathodes obliquus and Chromis enchrysura). Planktivores dominated fish assemblages, particularly in the upper mesophotic zone, possibly due to a greater availability of zooplankton coming from the colder Equatorial Undercurrent in mesophotic depths of the SPSPA. Turf algae, fleshy macroalgae and scleractinian corals dominated benthic assemblages between 30 and 40 m depth, while bryozoans, black corals and sponges dominated between 40 and 90 m depth. Canonical correspondence analysis explained 74 % of the relationship between environmental characteristics (depth, benthic cover and complexity) and structure of fish assemblages, with depth as the most important independent variable. Juveniles of Bodianus insularis and adults of P. obliquus and C. enchrysura were clearly associated with branching black corals ( Tanacetipathes spp.), suggesting that black corals play key ecological roles in lower mesophotic reefs of the SPSPA. Results from this study add to the global database about mesophotic reef ecosystems (MREs) and provide a baseline for future evaluations of possible anthropogenic and natural disturbances on MREs of the SPSPA.

  10. A variation on forced migration: Wilhelm Peters (Prussia via Britain to Turkey) and Muzafer Sherif (Turkey to the United States).

    PubMed

    Russell, Gül

    2016-01-01

    In 1933 the Turkish Republic formally offered university positions to 30 German-speaking academics who were dismissed with the coming to power of the National Socialist Government. That initial number went up to 56 with the inclusion of the technical assistants. By 1948 the estimated total had increased to 199. Given renewable five-year contracts with salaries substantially higher than their Turkish counterparts, the foreign émigrés were to implement the westernization program of higher education. The ten year-old secular Turkish Republic's extensive social reforms had encompassed the adoption of the Latin alphabet, and equal rights for women, removing gender bias in hiring. Such a high concentration of émigré academics in one institution, "the highest anywhere in the world," provides a unique opportunity to study a subject which has been neglected. In this article two cases in psychology will be examined: Wilhelm Peters (1880-1963), who came, via Britain, to Istanbul in 1936 from the University of Jena in Germany, and Muzafer Sherif (1906-1988) who went to the United States from Ankara University in 1945. The purpose of the comparative analysis is to identify the features that are specific to the German experience, and those that are shared and underlie translocation in science within the multifaceted complexity of the process of forced migration. PMID:27388256

  11. Theoretical claims necessitate basic research: reply to Gawronski, Lebel, Peters, and Banse (2009) and Nosek and Greenwald (2009).

    PubMed

    De Houwer, Jan; Teige-Mocigemba, Sarah; Spruyt, Adriaan; Moors, Agnes

    2009-05-01

    The authors of this reply article note that B. Gawronski, E. P. LeBel, K. R. Peters, and R. Banse (a) expressed agreement in their comment with the analysis put forward in the target article (J. De Houwer, S. Teige-Mocigemba, A. Spruyt, & A. Moors) and (b) pointed to a further implication for the way in which the implicitness of a measure should be examined. The current authors note that B. A. Nosek and A. G. Greenwald, on the other hand, raised questions in their comment about the definition of the concept "implicit" in the target article, arguing for a fundamentally different approach to measurement that emphasizes not theoretical understanding but usefulness for predicting behavior. In this reply, the current authors respond to these comments and argue that when theoretical claims are made about measures, these claims should be backed up with appropriate evidence. In the absence of basic research, measures and their relation to behavior can only be described. (PsycINFO Database Record (c) 2009 APA, all rights reserved). PMID:19379021

  12. The expression of selected genes linked to metabolic homeostasis in obese pansteatitis-suffering Mozambique tilapia, Oreochromis mossambicus (Peters).

    PubMed

    Truter, J C; van Wyk, J H; Oberholster, P J; Botha, A-M; Luus-Powell, W J

    2016-01-01

    The Oreochromis mossambicus (Peters) population inhabiting Lake Loskop, South Africa, is characterized by a high incidence of obesity and pansteatitis. We investigated potential links between the impaired health of Lake Loskop O. mossambicus and the endocrine system by assessing the expression of selected genes associated with the thyroid and adrenal endocrine axes as well as peroxisome proliferator-activated receptor gamma (pparg). Moreover, contaminant-induced thyroid and/or metabolic modulation in Lake Loskop water was evaluated using juvenile O. mossambicus in laboratory exposures. The expression of thyroid hormone receptor alpha (thra) and type 2 deiodinase (dio2) was higher in Lake Loskop O. mossambicus than fish from another population, suggesting a degree of thyroid disruption. The altered gene expression may be a consequence, rather than cause of obesity. Expression of dio2 and pparg was higher in juvenile O. mossambicus exposed to unfiltered compared to filtered lake water, and our data suggest fasting as causative factor. Micro-organism abundance can therefore be a confounding factor in studies applying molecular markers to test for thyroid modulation by environmental waters. Pansteatitis was not a significant source of variance in the expression of any of the genes investigated, suggesting that the disease is not associated with disrupted endocrine signalling. PMID:25413848

  13. The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway.

    PubMed

    Pfister, Astrid S; Keil, Marina; Kühl, Michael

    2015-04-24

    Proper ribosome formation is a prerequisite for cell growth and proliferation. Failure of this process results in nucleolar stress and p53-mediated apoptosis. The Wnt target Peter Pan (PPAN) is required for 45 S rRNA maturation. So far, the role of PPAN in nucleolar stress response has remained elusive. We demonstrate that PPAN localizes to mitochondria in addition to its nucleolar localization and inhibits the mitochondrial apoptosis pathway in a p53-independent manner. Loss of PPAN induces BAX stabilization, depolarization of mitochondria, and release of cytochrome c, demonstrating its important role as an anti-apoptotic factor. Staurosporine-induced nucleolar stress and apoptosis disrupt nucleolar PPAN localization and induce its accumulation in the cytoplasm. This is accompanied by phosphorylation and subsequent cleavage of PPAN by caspases. Moreover, we show that PPAN is a novel interaction partner of the anti-apoptotic protein nucleophosmin (NPM). PPAN depletion induces NPM and upstream-binding factor (UBF) degradation, which is independent of caspases. In summary, we provide evidence for a novel nucleolar stress-response pathway involving PPAN, NPM, and BAX to guarantee cell survival in a p53-independent manner. PMID:25759387

  14. Peter Pan functions independently of its role in ribosome biogenesis during early eye and craniofacial cartilage development in Xenopus laevis.

    PubMed

    Bugner, Verena; Tecza, Aleksandra; Gessert, Susanne; Kühl, Michael

    2011-06-01

    The Xenopus oocyte possesses a large maternal store of ribosomes, thereby uncoupling early development from the de novo ribosome biosynthesis required for cell growth. Brix domain-containing proteins, such as Peter Pan (PPan), are essential for eukaryotic ribosome biogenesis. In this study, we demonstrate that PPan is expressed maternally as well as in the eye and cranial neural crest cells (NCCs) during early Xenopus laevis development. Depletion of PPan and interference with rRNA processing using antisense morpholino oligonucleotides resulted in eye and cranial cartilage malformations. Loss of PPan, but not interference with rRNA processing, led to an early downregulation of specific marker genes of the eye, including Rx1 and Pax6, and of NCCs, such as Twist, Slug and FoxD3. We found that PPan protein is localized in the nucleoli and mitochondria and that loss of PPan results in increased apoptosis. These findings indicate a novel function of PPan that is independent of its role in ribosome biogenesis. PMID:21558383

  15. The business against case revolution. An interview with Nestlé's Peter Brabeck. Interview by Sue Wetlaufer.

    PubMed

    Brabeck, P

    2001-02-01

    One of the world's most enduring companies, Nestle epitomizes everything that today's high-flying, headline-grabbing companies are not. It respects technology but doesn't consider it central to strategy. It values growth but prefers it controlled. It seeks talented professionals but wants only those who are modest in word and deed. Nestle CEO Peter Brabeck is skeptical of the relentless push for radical transformation heard from every quarter. He believes, instead, in continuous improvement through slow and steady change. Big, dramatic change is fine for a crisis, Brabeck says, but not every company is in crisis all the time. Many companies are like Nestle--performing well, growing and innovating, without frenzy, without bloodshed. While he acknowledges that every company must change in order to compete in today's turbulent marketplace, Brabeck makes the focus of his work identifying and strengthening those aspects of Nestle that should stay the same. For example, Nestle eschews the noise and energy swirling around technology. Many companies make technology the focal point of strategy, Brabeck says, but Nestle is about people, products, and brands. The company uses technology to create better products but keeps it in its right place--the background. Brabeck also talks candidly about how to fight complacency in a successful company, how to institutionalize collaboration in a decentralized organization, and how to resist pressure from analysts and money managers and focus on long-term, sustainable and profitable growth--in short, how to win the war without the revolution. PMID:11213685

  16. FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1

    PubMed Central

    Khan, Shahid Y.; Vasanth, Shivakumar; Kabir, Firoz; Gottsch, John D.; Khan, Arif O.; Chaerkady, Raghothama; Lee, Mei-Chong W.; Leitch, Carmen C.; Ma, Zhiwei; Laux, Julie; Villasmil, Rafael; Khan, Shaheen N.; Riazuddin, Sheikh; Akram, Javed; Cole, Robert N.; Talbot, C. Conover; Pourmand, Nader; Zaghloul, Norann A.; Hejtmancik, J. Fielding; Riazuddin, S. Amer

    2016-01-01

    FOXE3 is a lens-specific transcription factor that has been associated with anterior segment ocular dysgenesis. To determine the transcriptional target(s) of FOXE3 that are indispensable for the anterior segment development, we examined the transcriptome and the proteome of cells expressing truncated FOXE3 responsible for Peters anomaly identified through linkage-coupled next-generation whole-exome sequencing. We found that DNAJB1, an autophagy-associated protein, was the only candidate exhibiting differential expression in both screens. We confirmed the candidacy of DNAJB1 through chromatin immunoprecipitation and luciferase assays while knockdown of DNAJB1 in human lens epithelial cells resulted in a mitotic arrest. Subsequently, we targeted dnajb1a in zebrafish through injection of a splice-blocking morpholino. The dnajb1a morphants exhibited underdeveloped cataractous lenses with persistent apoptotic nuclei. In conclusion, here we report DNAJB1 is a transcriptional target of FOXE3 in a novel pathway that is crucial for the development of the anterior segment of the eye. PMID:27218149

  17. Morphological and karyotypic differentiation in Caranx lugubris (Perciformes: Carangidae) in the St. Peter and St. Paul Archipelago, mid-Atlantic Ridge

    NASA Astrophysics Data System (ADS)

    Jacobina, Uedson Pereira; Martinez, Pablo Ariel; Cioffi, Marcelo de Bello; Garcia, José; Bertollo, Luiz Antonio Carlos; Molina, Wagner Franco

    2014-03-01

    Isolated oceanic islands constitute interesting model systems for the study of colonization processes, as several climatic and oceanographic phenomena have played an important role in the history of the marine ichthyofauna. The present study describes the presence of two morphotypes of Caranx lugubris, in the St. Peter and St. Paul Archipelago located in the mid-Atlantic. Morphotypes were compared in regard to their morphological and cytogenetic patterns, using C-banding, Ag-NORs, staining with CMA3/DAPI fluorochromes and chromosome mapping by dual-color FISH analysis with 5S rDNA and 18S rDNA probes. We found differences in chromosome patterns and marked divergence in body patterns which suggest that different populations of the Atlantic or other provinces can be found in the Archipelago of St. Peter and St. Paul.

  18. The results of monitoring of hazardous natural processes in the coastal shelf zone of the gulf of Peter the Great in 2012-2013

    NASA Astrophysics Data System (ADS)

    Anokhin, Vladimir; Shcherbakov, Victor; Motychko, Victor; Sokolov, Georgy; Kotov, Sergey; Kartashov, Alexander; Anokhina (1)(2), Zoya

    2014-05-01

    The monitoring of hazardous natural processes In coastal and shelf zone of the gulf of Peter the Great (sea of Japan) in 2012-2013 was made by staff of the Gramberg Institute VNIIOKEANGEOLOGIA . The complex of field researches are: - laser scanning beaches (tachometer Leica HDS 3000); - echosounding underwater coastal slope (sounder-Navigator LCX-37C); - high-frequency acoustic profiling (GeoPulse Subbotom Profilier); - hydromagnetic shooting magnetometer SeaSPY Marine Magnetics; - sonar shooting (complex GEO-CM-MAX); - research of the water column (sounding and sampling); - bottom sampling, including gasgeochemical shooting. The result of this work is the following conclusions: 1. As the shore, and the underwater slope of the district are experiencing the preemptive destruction, the areas of which are quantitative and spatially prevail over the stable and accumulate zones (except the shores of the inland parts of bays and gulfs). 2. The rate of destruction of coast in the Gulf of Peter the Great is 1-20 meters for 100 years, that could pose a serious danger to the population and infrastructure. 3. Number of gasgeochemical anomalies on the shelf of the Gulf of Peter the Great spatially associated with fault lines, limiting blocks of the earth's crust within shelf. 4. Perhaps it is these faults are of the greatest seismic hazard in the moment. 5. Danger of themselves gas emissions The following significant hazards and risks to the region have been studied: seismic and tsunami destruction of shore, gas emissions, technogenic pollution.

  19. The Peter Pan paradigm.

    PubMed

    Cohen, J Craig; Larson, Janet E

    2008-01-01

    Genetic and environmental agents that disrupt organogenesis are numerous and well described. Less well established, however, is the role of delay in the developmental processes that yield functionally immature tissues at birth. Evidence is mounting that organs do not continue to develop postnatally in the context of these organogenesis insults, condemning the patient to utilize under-developed tissues for adult processes. These poorly differentiated organs may appear histologically normal at birth but with age may deteriorate revealing progressive or adult-onset pathology. The genetic and molecular underpinning of the proposed paradigm reveals the need for a comprehensive systems biology approach to evaluate the role of maternal-fetal environment on organogenesis."You may delay, but time will not" Benjamin Franklin, USA Founding Father. PMID:18182112

  20. Reproduction of Blackfin tuna Thunnus atlanticus (Perciformes: Scombridae) in Saint Peter and Saint Paul Archipelago, Equatorial Atlantic, Brazil.

    PubMed

    Bezerra, Natalia P A; Fernandes, Cezar A F; Albuquerque, Fernanda V; Pedrosa, Vanessa; Hazin, Fábio; Travassos, Paulo

    2013-09-01

    The reproduction of Blackfin tuna Thunnus atlanticus has been described for coastal regions, and for a long time, this species was considered to be a strictly continental spawner. Recently, this species was observed around a seamount habitat 500 nautical miles Northeast of Brazil, located between South America and Africa. In this study we describe the reproductive biology of Blackfin tuna at Saint Peter and Saint Paul Archipelago (SPSPA). Male and female gonads were sampled from December 2008 to July 2010, and analyzed macro and microscopically. A total of 361 fish were sampled (247 males and 114 females). Males were more common than females, with a sex ratio of 2.2 male:1 female. The fork length (FL) of all sampled specimens ranged from 38 to 98cm, and larger length classes were more frequent in males. It was possible to distinguish six maturity phases for females: immature, developing, spawning capable, actively spawning, regressing and recovering. Five phases were identified for males: immature, developing, spawning capable, actively spawning and recovering. The gonad index (GI) mean monthly values ranged from 6.6 (SD = 4.1) to 58.4 (SD = 34.7) for females, and from 2.6 (SD = 1.3) to 66.2 (SD = 30.4) for males. For both sexes, the largest GI values were observed at the beginning of the first semester of the year. Size at first maturity was estimated at 48cm FL and 55cm FL for females and males respectively. Approximately 80% of the specimens were adults and considered to be in reproductive conditions. Histological analysis of the ovaries and testes showed that most of the specimens were sexually mature and were reproductively active during all months of the year. However, females with mature ovaries, with large amounts of hydrated oocytes and post-ovulatory follicles, were mainly found from December to March, thus these months may constitute the main spawning season in SPSPA. Batch fecundity varied between 272025 and 1,140584 oocytes for 56 and 68 cm FL females

  1. Karyotypic variation in Rhinophylla pumilio Peters, 1865 and comparative analysis with representatives of two subfamilies of Phyllostomidae (Chiroptera)

    PubMed Central

    Gomes, Anderson José Baia; Nagamachi, Cleusa Yoshiko; Rodrigues, Luís Reginaldo Ribeiro; Farias, Solange Gomes; Rissino, Jorge Dores; Pieczarka, Julio Cesar

    2012-01-01

    Abstract The family Phyllostomidae belongs to the most abundant and diverse group of bats in the Neotropics with more morphological traits variation at the family level than any other group within mammals. In this work, we present data of chromosome banding (G, C and Ag-NOR) and Fluorescence In Situ Hybridization (FISH) for representatives of Rhinophylla pumilio Peters, 1865 collected in four states of Brazil (Amazonas, Bahia, Mato Grosso and Pará). Two karyomorphs were found in this species: 2n=34, FN=64 in populations from western Pará and Mato Grosso states and 2n=34, FN=62 from Amazonas, Bahia, and northeastern Pará and Marajó Island (northern). Difference in the Fundamental Number is determined by variation in the size of the Nucleolar Organizer Region (NOR) accompanied with heterochromatin on chromosomes of pair 16 or, alternatively, a pericentric inversion. The C-banding technique detected constitutive heterochromatin in the centromeric regions of all chromosomes and on the distal part of the long arm of pair 15 of specimens from all localities. FISH with a DNA telomeric probe did not show any interstitial sequence, and an 18S rDNA probe and silver staining revealed the presence of NOR in the long arm of the pair 15, associated with heterochromatin, and in the short arm of the pair 16 for all specimens. The intra-specific analysis using chromosome banding did not show any significant difference between the samples. The comparative analyses using G-banding have shown that nearly all chromosomes of Rhinophylla pumilio were conserved in the chromosome complements of Glossophaga soricina Pallas, 1766, Phyllostomus hastatus Pallas, 1767, Phyllostomus discolor Wagner, 1843 and Mimon crenulatum Geoffroy, 1801, with a single chromosomal pair unique to Rhinophylla pumilio (pair 15). However, two chromosomes of Mimon crenulatum are polymorphic for two independent pericentric inversions. The karyotype with 2n=34, NF=62 is probably the ancestral one for the other

  2. mtDNA perspective of chromosomal diversification and hybridization in Peters' tent-making bat (Uroderma bilobatum: Phyllostomidae).

    PubMed

    Hoffmann, Federico G; Owen, James G; Baker, Robert J

    2003-11-01

    We compared sequence variation in the complete mitochondrial cytochrome-b gene with chromosomal and geographical variation for specimens of Peters' tent-making bat (Uroderma bilobatum). Three different chromosomal races have been described in this species: a 2n = 42 race from South America east of the Andes, a 2n = 44 from NW Central America and 2n = 38 from the rest of Central America and NW South America. The deepest nodes in the tree were found within the South American race (42 race), which is consistent with a longer history of this race. Average distance among races ranged from 2.5 to 2.9%, with the highest amount of intraracial variation found within the 2n = 42 race (1.7%), intermediate values within the 2n = 38 race (0.9%) and lowest within the 2n = 44 race (0.5%). Variation among chromosomal races accounted for over 55% of molecular variance, whereas variation among populations within races accounted for 6%. The 2n = 38 and 2n = 44 races hybridize in the coastal lowlands of Honduras, near the Gulf of Fonseca. Introgression between these two races is low (two introgressed individuals in 45 examined). Clinal variation across the hybrid zone for the cytochrome-b of U. bilobatum, is similar to clinal variation reported for chromosomes and isozymes of this species. Mismatch distribution analyses suggests that geographical isolation and karyological changes have interplayed in a synergistic fashion. Fixation of the alternative chromosomal rearrangements in geographical isolation and secondary contact is the most likely mechanism accounting for the hybrid zone between the 2n = 38 and 2n = 44 races. If a molecular clock is assumed, with rates ranging from 2.3 to 5.0% per million years, then isolation between these races occurred within the last million years, implying a relatively recent origin of the extant diversity in Uroderma bilobatum. None the less, the three chromosomal races probably represent three different biological species. PMID:14629379

  3. Disruption of the splicing enhancer sequence within exon 27 of the dystrophin gene by a nonsense mutation induces partial skipping of the exon and is responsible for Becker muscular dystrophy.

    PubMed Central

    Shiga, N; Takeshima, Y; Sakamoto, H; Inoue, K; Yokota, Y; Yokoyama, M; Matsuo, M

    1997-01-01

    The mechanism of exon skipping induced by nonsense mutations has not been well elucidated. We now report results of in vitro splicing studies which disclosed that a particular example of exon skipping is due to disruption of a splicing enhancer sequence located within the exon. A nonsense mutation (E1211X) due to a G to T transversion at the 28th nucleotide of exon 27 (G3839T) was identified in the dystrophin gene of a Japanese Becker muscular dystrophy case. Partial skipping of the exon resulted in the production of truncated dystrophin mRNA, although the consensus sequences for splicing at both ends of exon 27 were unaltered. To determine how E1211X induced exon 27 skipping, the splicing enhancer activity of purine-rich region within exon 27 was examined in an in vitro splicing system using chimeric doublesex gene pre-mRNA. The mutant sequence containing G3839T abolished splicing enhancer activity of the wild-type purine-rich sequence for the upstream intron in this chimeric pre-mRNA. An artificial polypurine oligonucleotide mimicking the purine-rich sequence of exon 27 also showed enhancer activity that was suppressed by the introduction of a T nucleotide. Furthermore, the splicing enhancer activity was more markedly inhibited when a nonsense codon was created by the inserted T residue. This is the first evidence that partial skipping of an exon harboring a nonsense mutation is due to disruption of a splicing enhancer sequence. PMID:9410897

  4. Disruption of the splicing enhancer sequence within exon 27 of the dystrophin gene by a nonsense mutation induces partial skipping of the exon and is responsible for Becker muscular dystrophy.

    PubMed

    Shiga, N; Takeshima, Y; Sakamoto, H; Inoue, K; Yokota, Y; Yokoyama, M; Matsuo, M

    1997-11-01

    The mechanism of exon skipping induced by nonsense mutations has not been well elucidated. We now report results of in vitro splicing studies which disclosed that a particular example of exon skipping is due to disruption of a splicing enhancer sequence located within the exon. A nonsense mutation (E1211X) due to a G to T transversion at the 28th nucleotide of exon 27 (G3839T) was identified in the dystrophin gene of a Japanese Becker muscular dystrophy case. Partial skipping of the exon resulted in the production of truncated dystrophin mRNA, although the consensus sequences for splicing at both ends of exon 27 were unaltered. To determine how E1211X induced exon 27 skipping, the splicing enhancer activity of purine-rich region within exon 27 was examined in an in vitro splicing system using chimeric doublesex gene pre-mRNA. The mutant sequence containing G3839T abolished splicing enhancer activity of the wild-type purine-rich sequence for the upstream intron in this chimeric pre-mRNA. An artificial polypurine oligonucleotide mimicking the purine-rich sequence of exon 27 also showed enhancer activity that was suppressed by the introduction of a T nucleotide. Furthermore, the splicing enhancer activity was more markedly inhibited when a nonsense codon was created by the inserted T residue. This is the first evidence that partial skipping of an exon harboring a nonsense mutation is due to disruption of a splicing enhancer sequence. PMID:9410897

  5. Reply to comment by Peters et al. (2015) on "Cosmogenic 180W variations in meteorites and re-assessment of a possible 184Os-180W decay system"

    NASA Astrophysics Data System (ADS)

    Cook, David L.; Kruijer, Thomas S.; Leya, Ingo; Kleine, Thorsten

    2015-11-01

    Peters et al. (2014) argued that ε180W excesses in iron meteorites originated as the decay product of 184Os. They also suggested that compositional heterogeneities, leading to variable Os/W ratios within a single iron, was the most likely explanation for discrepant ε180W values measured in different studies of the same meteorites. In Cook et al. (2014), we showed that irradiation by galactic cosmic rays (GCR) can induce large variations in ε180W. These effects provide at least a partial explanation for the observed ε180W excesses. Additionally, they can explain why ε180W values may vary both among members of a particular iron meteorite group (e.g., IVB irons), as well as between different specimens of a single iron meteorite (e.g., Weaver Mountains). We used GCR-corrected ε180W data to re-estimate the possible role of 184Os decay in generating ε180W excesses and found that any radiogenic production of 180W was much smaller than suggested by Peters et al. (2014). The preceding comment by Peters et al. (2015) on our 2014 paper contains criticisms that focus mainly on the following topics: the influence of an s-process deficit in W isotopes on ε180W in some iron meteorites, our sample selection for the construction of our isochron, and the potential effect of sample compositional heterogeneity on Os/W ratios and how this may impact our isochron slope. We address each of these in turn below.

  6. XRF investigation on skeletal remains from King Peter III of Aragon (1239-1285 A.D.) and Queen Blanche of Anjou (1280-1310 A.D.)

    NASA Astrophysics Data System (ADS)

    Piga, Giampaolo; Brunetti, Antonio; Lasio, Barbara; Enzo, Stefano; Malgosa, Assumpció

    2014-03-01

    We conducted an X-Ray Fluorescence investigation on bone fragments belonging to King Peter III of Aragon and Queen Blanche of Anjou. The spectroscopic analysis was carried out in selected points of the bone fragments. Several transitional elements normally unexpected in the bone composition have been found at varying level of concentration. The presence of these elements was interpreted in relation to chemical treatments for mummification of bodies as well as to dietary habits, including tools used for cooking and for the consumption of food.

  7. AVTA Federal Fleet PEV Readiness Data Logging and Characterization Study for Department of Veterans Affairs. James J. Peters VA Medical Center, Bronx, NY

    SciTech Connect

    Schey, Stephen; Francfort, Jim

    2014-10-01

    This report focuses on the Department of Veterans Affairs, James J. Peters VA Medical Center (VA - Bronx) fleet to identify daily operational characteristics of select vehicles and report findings on vehicle and mission characterizations to support the successful introduction of PEVs into the agencies’ fleets. Individual observations of these selected vehicles provide the basis for recommendations related to electric vehicle adoption and whether a battery electric vehicle or plug-in hybrid electric vehicle (collectively referred to as PEVs) can fulfill the mission requirements.

  8. From Civil Protection Plan to Disaster Management. PETer evolution from GIS tool to multi-area Emergency Management System

    NASA Astrophysics Data System (ADS)

    Frigerio, Simone; Sterlacchini, Simone; Malet, Jean-Philippe; Glade, Thomas

    2010-05-01

    PETer (Protection and Emergency of the Territory) has been developed since 2006 as a tool to manage all the information available to perform a wide range of Civil Protection activities. Based on MapObjects spatial support, it was relied on capacity to manage data from different sources and at different scale, offering practical GIS-tools for a technical and practical use during crisis state. At the first stages of the development, after different assessment, critical on-field analysis and a direct proof on test area, the approach came into sight like a valid database management for the entire dataset, but quite static, not full-blown for every emergency necessity, too complicate and not enough user-friendly, considering people in charge during emergency management, the quick change of state with many parameters involved and also uncertainty, hesitation, confusion or general panic among decision makers. As a second step of research, a more down-to-earth methodology targeted to cope with the aftermath of critical events is presented here. It takes advantage of Geographical Information Systems (GIS), Decision Support Systems (DSS), and Information and Communication Technology (ICT) to prepare, apply and coordinate Civil Protection plans. The main aim was to set up and manage contingency plans in advance; that is, to identify and prepare people in charge to take action to define the activities to be performed, to be aware of available resources and to optimize the communication system among the people involved, in order to efficiently face a prospective crisis phase. A disaster preparedness plan should anticipate the demands for a disaster relief operation and indicate the most effective way of joining those requirements. Through scientific and technical co-operation between public and private research groups, a new platform was planned and set up, in order to test the aims of the project. The application was based on a cooperative organizational structure by which

  9. Types of species of Apionidae (Coleoptera) described by Carl Peter Thunberg (1743–1828) with description of a new genus

    PubMed Central

    Alonso-Zarazaga, Miguel A.

    2013-01-01

    Abstract The type specimens of species of Apionidae described by Carl Peter Thunberg are reviewed and lecto- and paralectotypes are designated for Apion craccae Thunberg, 1813, Apion limbatum Thunberg, 1813, Apion punctigerum Thunberg, 1815 and Apion astragali Thunberg, 1815. A new genus Thunbergapion (type species Apion limbatum Thunberg, 1813) is described, figured and placed in the tribe Aplemonini Kissinger, 1968. The new combination Thunbergapion limbatum (Thunberg, 1813) is proposed. A key to the known South African genera of the tribe is given. The following new synonymies are established: Oxystoma craccae (Linnaeus, 1767) = Apion craccae Thunberg, 1813 syn. n., Ischnopterapion (Ischnopterapion) loti (Kirby, 1808) = Apion punctigerum Thunberg, 1815, syn. n., and Pseudoprotapion astragali (Paykull, 1800) = Apion astragali Thunberg, 1815, syn. n. PMID:23950673

  10. [Poverty, demographic growth, and birth control: a critique of Peter Singer s ethical perspective on the relationship between rich and poor].

    PubMed

    Romero, D E

    1998-01-01

    This article analyzes the relationship between population growth and ethical principles relating to poverty. The paper is a critical approach to the thesis presented by Peter Singer in his book Practical Ethics. The first part briefly examines the principal topics of his thesis. The author then analyzes the basis of Singer's theory with respect to the following questions: 1. Is overpopulation the main reason for poverty? Is it possible to establish an association between the poverty phenomenon and population growth? 2. Is Singer s demographic perspective valid? 3. Can problems of resource distribution be ignored when talking about poverty from an ethical perspective? 4. Is it true that birth control policy was successfully implemented in Mexico, Colombia, and Brazil? 5. Does Singer s position on population growth have a negative influence on the "collective imagination"? The paper concludes by suggesting some useful arguments for understanding an ethical perspective towards poverty. PMID:9761607

  11. [Ecological groups of flatfishes of Peter the Great Bay (Japan sea) based on the analysis od species composition of myxosporidian parasites].

    PubMed

    Antonenko, D V; Aseeva, N L

    2010-01-01

    Comparison of myxosporidian species compositions in different flatfish species fro Peter the Great Bay showed that the flatfishes should be divided into three ecological groups--deep water (scaly-eyed plaice Acanthopsetta nadeshnyi, Korean flounder Glyptocephalus stelleri, flatheaded flounder Hippoglossoides dubius, and pinewood flounder Cleisthenes herzensteini), relatively coastal (yellow-finned sole Limanda aspera and brown sole Pseudopleuronectes herzensteini), and coastal (Japanese flounder Pseudopleuronectes yokohamae, long-snouted flounder Limanda punctatissimus, starry flounder Platichthys stellatus, and white-bellied flounder Lepidopsetta mochigarei). This division coincides in general with the previously proposed ecological classification based on the characteristics of bathymetric distribution and preference to water layers during summer period in the fishes. PMID:20536006

  12. CO{sub 2} Injectivity, Storage Capacity, Plume Size, and Reservoir and Seal Integrity of the Ordovician St. Peter Sandstone and the Cambrian Potosi Formation in the Illnois Basin

    SciTech Connect

    Leetaru, Hannes; Brown, Alan; Lee, Donald; Senel, Ozgur; Coueslan, Marcia

    2012-05-01

    The Cambro-Ordovician strata of the Illinois and Michigan Basins underlie most of the states of Illinois, Indiana, Kentucky, and Michigan. This interval also extends through much of the Midwest of the United States and, for some areas, may be the only available target for geological sequestration of CO{sub 2}. We evaluated the Cambro-Ordovician strata above the basal Mt. Simon Sandstone reservoir for sequestration potential. The two targets were the Cambrian carbonate intervals in the Knox and the Ordovician St. Peter Sandstone. The evaluation of these two formations was accomplished using wireline data, core data, pressure data, and seismic data from the USDOE-funded Illinois Basin Decatur Project being conducted by the Midwest Geological Sequestration Consortium in Macon County, Illinois. Interpretations were completed using log analysis software, a reservoir flow simulator, and a finite element solver that determines rock stress and strain changes resulting from the pressure increase associated with CO{sub 2} injection. Results of this research suggest that both the St. Peter Sandstone and the Potosi Dolomite (a formation of the Knox) reservoirs may be capable of storing up to 2 million tonnes of CO{sub 2} per year for a 20-year period. Reservoir simulation results for the St. Peter indicate good injectivity and a relatively small CO{sub 2} plume. While a single St. Peter well is not likely to achieve the targeted injection rate of 2 million tonnes/year, results of this study indicate that development with three or four appropriately spaced wells may be sufficient. Reservoir simulation of the Potosi suggest that much of the CO{sub 2} flows into and through relatively thin, high permeability intervals, resulting in a large plume diameter compared with the St. Peter.

  13. Paleomagnetism of the Becker Peak stock

    NASA Astrophysics Data System (ADS)

    Miller, B. A.; Housen, B. A.

    2009-12-01

    Paleomagnetic studies of plutonic rocks, although subject to uncertainty due to lack of paleohorizontal control, can provide important constrains of patterns of regional deformation, and can play a role in evaluation of tectonic models and reconstructions. Many plutonic rocks of the Cascades have been well-studied via paleomagnetism, but there are many that lack robust data sets. One such pluton, the Beckler Peak stock, is a late Cretaceous tonalitic stock, with biotite and amphibole K-Ar ages of 93 to 82 Ma (Engels and Crowder, 1971, Yeats and Engels, 1971). The Beckler Peak stock is considered to be a companion body to the larger Mt. Stuart Batholith, but is separated from the Mt. Stuart Batholith by the Evergreen Fault. For this study five paleomagnetic sites were sampled from the Beckler Peak stock near Skykomish, Washington. After low temperature and thermal demagnetization site means were calculated for the four sites where at least two samples survived demagnetization. Unblocking temperatures were indicative of magnetite and hematite as the carriers of remanence. Two of the site means were disregarded due to anomalous directions likely due to sites being from very large slump blocks. The two acceptable site means, along with a Beckler Peak stock site mean from Beck and Noson (1972) and another from Housen et al. (2003) give a stock-wide mean of D = 3.8°, I = 41.9°, k = 32.9, and α95 = 16.2°. This direction is consistent with mean directions for the Mount Stuart batholith determined by Beck and Noson (1972), Beck et al. (1981), and Housen et al. (2003). This directional consistency supports an association between the Beckler Peak stock and the Mt. Stuart Batholith, or at least that these two plutonic bodies were emplaced in the same structural block, and that any post-magnetization deformation (such as rotation and/or tilt associated with the Evergreen Fault) between the Beckler Peak stock and the Mt. Stuart Batholith was minor.

  14. Digenetic Changes in Macro- to Nano-Scale Porosity in the St. Peter Sandstone:L An (Ultra) Small Angle Neutron Scattering and Backscattered Electron Imagining Analysis

    SciTech Connect

    Anovitz, Lawrence {Larry} M; Cole, David; Rother, Gernot; Allard Jr, Lawrence Frederick; Jackson, Andrew; Littrell, Ken

    2013-01-01

    Small- and Ultra-Small Angle Neutron Scattering (SANS and USANS) provide powerful tools for quantitative analysis of porous rocks, yielding bulk statistical information over a wide range of length scales. This study utilized (U)SANS to characterize shallowly buried quartz arenites from the St. Peter Sandstone. Backscattered electron imaging was also used to extend the data to larger scales. These samples contain significant volumes of large-scale porosity, modified by quartz overgrowths, and neutron scattering results show significant sub-micron porosity. While previous scattering data from sandstones suggest scattering is dominated by surface fractal behavior over many orders of magnitude, careful analysis of our data shows both fractal and pseudo-fractal behavior. The scattering curves are composed of subtle steps, modeled as polydispersed assemblages of pores with log-normal distributions. However, in some samples an additional surface-fractal overprint is present, while in others there is no such structure, and scattering can be explained by summation of non-fractal structures. Combined with our work on other rock-types, these data suggest that microporosity is more prevalent, and may play a much more important role than previously thought in fluid/rock interactions.

  15. Spatial distribution of the crab larvae (Decapoda: Anomura et Brachyura) in Possyet Bay (Peter the Great Bay of the Sea of Japan) in 2000-2001

    NASA Astrophysics Data System (ADS)

    Grigoryeva, N. I.

    2009-10-01

    The analysis of the data obtained during the plankton surveys in Possyet Bay (Peter the Great Bay of the Sea of Japan) in 2000-2001 is presented. The larvae of eight crab species were registered in the plankton: the red king crab Paralithodes camtschaticus (Tilesius, 1815), the snow (opilio) crab Chionoecetes opilio (Fabricius, 1780), the Arctic lyre crab Hyas coarctatus ursinus (Leach, 1815), the kelp crab Pugettia quadridens (de Haan, 1839), the helmet crab Telmessus cheiragonus (Tilesius, 1815), the Japanese swimming crab Charybdis japonica (A. Milne-Edwards, 1861), the pea crab Pinnixa rathbuni (Sakai, 1934), and the porcelain crab Pachycheles stevensii (Stimpson, 1858). These species belonged to six families: Lithodidae, Atelecyclidae, Majidae, Portunidae, Porcellanidae, and Pinnotheridae. The role of the variability of some of the hydrological factors in the meroplankton larvae development was studied. In May, the crab larvae were found mostly in the open part of the bay. In June, they were transported by the current to the northern part of the bay. In July, they spread uniformly in all the bay areas; however, patchiness was observed. The maximal population density of the crab larvae was registered for July and varied from 6.8 to 23.3 ind. m-3. The crab larvae appeared in the plankton in 2000 and 2001 earlier than for the average season.

  16. Turbulence-driven shifts in holobionts and planktonic microbial assemblages in St. Peter and St. Paul Archipelago, Mid-Atlantic Ridge, Brazil.

    PubMed

    Moreira, Ana Paula B; Meirelles, Pedro M; Santos, Eidy de O; Amado-Filho, Gilberto M; Francini-Filho, Ronaldo B; Thompson, Cristiane C; Thompson, Fabiano L

    2015-01-01

    The aim of this study was to investigate the planktonic and the holobiont Madracis decactis (Scleractinia) microbial diversity along a turbulence-driven upwelling event, in the world's most isolated tropical island, St Peter and St Paul Archipelago (SPSPA, Brazil). Twenty one metagenomes were obtained for seawater (N = 12), healthy and bleached holobionts (N = 9) before, during and after the episode of high seawater turbulence and upwelling. Microbial assemblages differed between low turbulence-low nutrient (LLR) and high-turbulence-high nutrient (HHR) regimes in seawater. During LLR there was a balance between autotrophy and heterotrophy in the bacterioplankton and the ratio cyanobacteria:heterotrophs ~1 (C:H). Prochlorales, unclassified Alphaproteobacteria and Euryarchaeota were the dominant bacteria and archaea, respectively. Basic metabolisms and cyanobacterial phages characterized the LLR. During HHR C:H < < 0.05 and Gammaproteobacteria approximated 50% of the most abundant organisms in seawater. Alteromonadales, Oceanospirillales, and Thaumarchaeota were the dominant bacteria and archaea. Prevailing metabolisms were related to membrane transport, virulence, disease, and defense. Phages targeting heterotrophs and virulence factor genes characterized HHR. Shifts were also observed in coral microbiomes, according to both annotation-indepent and -dependent methods. HHR bleached corals metagenomes were the most dissimilar and could be distinguished by their di- and tetranucleotides frequencies, Iron Acquision metabolism and virulence genes, such as V. cholerae-related virulence factors. The healthy coral holobiont was shown to be less sensitive to transient seawater-related perturbations than the diseased animals. A conceptual model for the turbulence-induced shifts is put forward. PMID:26483769

  17. Turbulence-driven shifts in holobionts and planktonic microbial assemblages in St. Peter and St. Paul Archipelago, Mid-Atlantic Ridge, Brazil

    PubMed Central

    Moreira, Ana Paula B.; Meirelles, Pedro M.; Santos, Eidy de O.; Amado-Filho, Gilberto M.; Francini-Filho, Ronaldo B.; Thompson, Cristiane C.; Thompson, Fabiano L.

    2015-01-01

    The aim of this study was to investigate the planktonic and the holobiont Madracis decactis (Scleractinia) microbial diversity along a turbulence-driven upwelling event, in the world's most isolated tropical island, St Peter and St Paul Archipelago (SPSPA, Brazil). Twenty one metagenomes were obtained for seawater (N = 12), healthy and bleached holobionts (N = 9) before, during and after the episode of high seawater turbulence and upwelling. Microbial assemblages differed between low turbulence-low nutrient (LLR) and high-turbulence-high nutrient (HHR) regimes in seawater. During LLR there was a balance between autotrophy and heterotrophy in the bacterioplankton and the ratio cyanobacteria:heterotrophs ~1 (C:H). Prochlorales, unclassified Alphaproteobacteria and Euryarchaeota were the dominant bacteria and archaea, respectively. Basic metabolisms and cyanobacterial phages characterized the LLR. During HHR C:H < < 0.05 and Gammaproteobacteria approximated 50% of the most abundant organisms in seawater. Alteromonadales, Oceanospirillales, and Thaumarchaeota were the dominant bacteria and archaea. Prevailing metabolisms were related to membrane transport, virulence, disease, and defense. Phages targeting heterotrophs and virulence factor genes characterized HHR. Shifts were also observed in coral microbiomes, according to both annotation–indepent and -dependent methods. HHR bleached corals metagenomes were the most dissimilar and could be distinguished by their di- and tetranucleotides frequencies, Iron Acquision metabolism and virulence genes, such as V. cholerae-related virulence factors. The healthy coral holobiont was shown to be less sensitive to transient seawater-related perturbations than the diseased animals. A conceptual model for the turbulence-induced shifts is put forward. PMID:26483769

  18. FOREWORD: Foreword from Peter Adams Foreword from Peter Adams

    NASA Astrophysics Data System (ADS)

    Adams, Peter D.

    2009-11-01

    As part of this twentieth anniversary special issue I was asked to write a few words about Richard Palmer, the one permanent fixture on the journal over its twenty year history. Richard and I go back a (very) long way! He began his career at IOP Publishing in Bristol in 1971 while my publishing career with the American Physical Society began a little earlier, located at Brookhaven National Laboratory on Long Island NY. Since then, and for nearly forty years we have met often, if irregularly, at many locations throughout the world. As members of two very strong physics organizations we were clearly in competition with each other to seek out and publish the best physics research. At the same time we frequently exchanged experiences and policy ideas for dealing with serious violations of scientific ethical standards and how academic society-run journals can best serve the general scientific community. Overall my relationship with Richard has been a most rewarding one and I shall miss his opinions and sage advice. Richard: Compatriot; competitor; collaborator; I salute you!

  19. Career perspective: Peter D Wagner

    PubMed Central

    2013-01-01

    This perspective focuses on key career decisions, explaining the basis of those decisions. In so doing, it exemplifies the unexpected influences of serendipity and the interaction between serendipity and planned events in shaping the career of one individual. PMID:24229460

  20. Genetics Home Reference: Peters anomaly

    MedlinePlus

    ... the anterior segment is abnormal, leading to incomplete separation of the cornea from the iris or the ... anomaly type I is characterized by an incomplete separation of the cornea and iris and mild to ...

  1. Career perspective: Peter D Wagner.

    PubMed

    Wagner, Peter D

    2013-01-01

    This perspective focuses on key career decisions, explaining the basis of those decisions. In so doing, it exemplifies the unexpected influences of serendipity and the interaction between serendipity and planned events in shaping the career of one individual. PMID:24229460

  2. "Peter, You Are a Writer"

    ERIC Educational Resources Information Center

    Fewell, Peter

    2011-01-01

    In prison, a man has the opportunity to learn something that is lacking in the world outside: respect. He respects those who respect him, because he has learned the value of respect. Another important opportunity is the chance to get on the education ladder and to earn some self-respect. The author was assessed as "illiterate" when he was jailed…

  3. Peter Pan in Coach's Gear

    ERIC Educational Resources Information Center

    Kravitz, Thomas J.

    1978-01-01

    Discusses physical activities for six age groups in the 4-month to 6-year range which emphasize the interaction between parent and child. Briefly describes those exercises which are appropriate for each age group. (BR)

  4. Databases: Peter's Picks and Pans.

    ERIC Educational Resources Information Center

    Jacso, Peter

    1995-01-01

    Reviews the best and worst in databases on disk, CD-ROM, and online, and offers judgments and observations on database characteristics. Two databases are praised and three are criticized. (Author/JMV)

  5. Illitization and paleothermal regimes in the Middle Ordovician St. Peter Sandstone, Central Michigan Basin: K-Ar, Oxygen Isotope, and fluid inclusion data

    SciTech Connect

    Girard, J.P.; Barnes, D.A.

    1995-01-01

    Hydrocarbon reservoirs occur in the Middle Ordovician St. Peter Sandstone in the central Michigan basin at depths of 1.5-3.5 km and are diagenetically altered. Latest diagenetic cements include saddle dolomite, pervasive microcrystalline illite and chlorite, and quartz. A K-Ar and {sup 18}O/{sup 16}O study of the fine-grained authigenic illite in 25 samples from 16 wells covering a large area within the basin yields K-Ar ages ranging from 367 to 322 Ma and {delta}{sup 18}O values between 12.7 and 16.9% SMOW. The {delta}{sup 18}O values of diagenetic quartz overgrowths range from 15.2 to 18.9%. Fluid inclusion temperatures in the quartz cement range from 70 to 170{degrees}C, reflecting multiple generations of diagenetic quartz and/or precipitation over most of the diagenetic history. Reequilibrated fluid inclusions in the saddle dolomite cement yield temperatures ranging from 90 to 150{degrees}C. A regionally significant episode of illitization occurred during the Late Devonian-Mississipian. Temperatures of illite formation are indirectly estimated to be in the range of 125-170{degrees}C and most paleodepths of illitization are between 2.8 and 3.2 km. These results imply that (1) illite formed from {sup 18}O-rich fluids, and (2) elevated geothermal gradients, i.e., greater than 34% C/km, existed in the Michigan basin in the late Paleozoic. The K-Ar ages and the {delta}{sup 18}O values are not correlated to present depths of the samples or paleodepths of illitization. Illites with young ages and low {delta}{sup 18}O values tend to be geographically distributed along the north-south branch of the buried Precambrian rift. The {delta}{sup 18}O values of the diagenetic quartz follow a similar trend. The spread of illite K-Ar ages and {delta}{sup 19}O values, and their geographic distribution, are best explained as reflecting abnormally high thermal regimes in the part of the basin located above the presumably highly fractured basement along the rift.

  6. [Molecular biology in genetic counseling of Duchenne and Becker myopathy].

    PubMed

    Philip, N; Voelckel, M A; Girardot, L; Lambert, J C; Moncla, A; Mattei, J F; Giraud, F

    1992-01-01

    From 1985-1991, molecular biology studies were carried out in 115 families affected with X-linked muscular dystrophy (DMD/BMD), including 59 prenatal diagnoses. The approach has changed over the last 6 years when new intragenic markers and cDNA probes became available. The polymerase chain reaction technique allows a rapid detection of dystrophin deletions, but classical Southern blot technique remains useful for restriction length polymorphism analysis. Fifty percent (42/85) of patients with DMD/BMD exhibited deletions of the dystrophin gene. In affected families with a detectable deletion, carrier detection is possible by gene dosage analysis and prenatal diagnosis is reliable. When no deletion is found, carrier detection and prenatal diagnosis depends on linkage analysis using polymorphic probes. Due to the high recombination rate, several markers need to be used. The information provided by linkage analysis must be interpreted given the proper family structure. PMID:1338927

  7. Summary of Gary Becker's IALL '93 Copyright Workshop, Part II.

    ERIC Educational Resources Information Center

    Starr, Irene

    1994-01-01

    This article covers the second part of a workshop on registering copyrighted materials, off-air video recording, using copyrighted videotapes in the classroom, and computer software copyright. The Copyright Law provides for the protection of the authors of creative works, while at the same time providing certain exemptions for educators and…

  8. 2008 - a year of three anniversaries: 125th anniversary of the Club for Natural Sciences in Fiume (Rijeka), 160th anniversary of the birth and 80th anniversary of the death of Professor Peter Salcher.

    PubMed

    Alebić-Juretić, Ana

    2009-01-01

    The Natural Science Club was founded in Fiume/Rijeka (Naturwissentschaflichen Club in Fiume/Club di scienze naturali in Fiume) on November 28th 1883. The foundation charter stipulated no restriction on language use, and lectures could be held in any language. Right from the start, the Club had active women members, and one of them, Rosa Fatour, the headmistress of the municipal school, held a lecture entitled "Development of anthropology" as early as in 1889. The Club started to publish a bilingual bulletin in German and Italian in 1896 (Mittheilungen des Naturwissenshaftlichen Clubs in Fiume/Bolletino del Club di scienze naturali in Fiume), bringing not only reports on lectures held in the Club, but also important scientific and professional papers. In 1896, several sections were founded within the Club, as follows: 1. The Committee for Röntgen, whose aim was to purchase the Röntgen apparatus. This task was completed in 1897. The apparatus was ceded to the municipal hospital in 1899, and the Committee was disbanded. 2. The Photography Section, lead initially by A. Riegler. The section organized several photo exhibitions in which women often took part.3. The Prehistoric Research Section was founded subsequent to the discovery of the remains of an old fortification in the town. This section collaborated closely with the municipal museum. Since founding and until 1902, Prof Peter Salcher held important positions in the Club; he founded the Röntgen Committee and the Photography Section; he himself gave 31 lectures and was editor of the German part of the Bulletin. PMID:20500010

  9. Peace and Pedagogy. Peter Lang Primers

    ERIC Educational Resources Information Center

    Quinn, Molly

    2014-01-01

    What makes for peace as lived? What images of peace issue from examination of daily experience? What can be gleaned from reflection upon the topic for the meanings and makings of peace in our world? Considering that to work for peace, we must begin with ourselves and with our children, Molly Quinn addresses these questions through her own life and…

  10. Meet the GPM Team: Carlton Peters

    NASA Video Gallery

    It takes hundreds of designers, engineers and technicians to build the largest spacecraft ever assembled at NASA's Goddard Space Flight Center, the GPM Core Observatory. Check out a few of the team...

  11. Peter Debye: Nazi collaborator or secret opponent?

    PubMed

    Reiding, Jurrie

    2010-11-01

    In January 2006, the so-called "Debye Affair" emerged, triggered by the publication of a Dutch book on Einstein. Debye was accused of Nazi collaboration in his capacity as chairman of the German Physical Society when he requested, in December 1938, the remaining Jewish members to leave the society. Within a month, two Dutch universities deleted Debye's name from their research institute and scientific award, and this led, both nationally and internationally, to a heated discussion. The Dutch government commissioned The Netherlands Institute for War Documentation to investigate the case. In its final report, the accusation was toned down to 'opportunism'. This paper is based on new information. Above all, I have researched Debye's extensive American archive. This archive disclosed the correspondence (1940-1963) with his friend Paul Rosbaud, an important MI6 intelligencer in Berlin during the Nazi period. The correspondence, combined with information from other sources, suggests that Debye might have been one of Rosbaud's informants. Therefore, this paper also includes a powerful warning against hasty and definitive conclusions. PMID:21465996

  12. PETER: Robots that watch the skies

    NASA Astrophysics Data System (ADS)

    Mora-Carrillo, G.; Rosenberg, A.

    2008-06-01

    We describe the user-access and analysis possible for a robotic telescope (the Liverpool Telescope) that can be used for educational and other use. Robotic telescopes operate with no staff on-site and the observations are remotely scheduled each night.

  13. Civic Youth Work Primer. Peter Lang Primers

    ERIC Educational Resources Information Center

    VeLure Roholt, Ross; Baizerman, Michael

    2013-01-01

    Apparent political apathy among youth in the United States has led to a moral panic about the future of democracy. Many researchers question the facts, while others seek to engage and mobilize young people around public issues they care about in order to master the citizen role and to bring social change. Civic youth work has its modern roots in…

  14. Genetics Home Reference: Peters plus syndrome

    MedlinePlus

    ... abnormalities, short stature, an opening in the lip ( cleft lip ) with or without an opening in the roof ... neck may also be broad and webbed. A cleft lip with or without a cleft palate is present ...

  15. 77 FR 72387 - Jeffery J. Becker, D.D.S., and Jeffery J. Becker, D.D.S., Affordable Care Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-05

    ... predecessor, the Bureau of Narcotics and Dangerous Drugs, see 36 FR 7802 (1971) (then codified at 21 CFR 307.... Associated Pharmaceutical Group, Inc., 58 FR 58181 (1993). Notably, the entity was unregistered and could not... 29. However, as the ALJ explained, in Daniel Koller, 71 FR 66975 (2006), I revoked the...

  16. Dictionary of Films. Translated, Edited, and Updated by Peter Morris.

    ERIC Educational Resources Information Center

    Sadoul, Georges

    In an attempt ot give a panorama of world cinema since its origins, this dictionary contains entries for about 1200 films from all over the world. A brief description of the plot of the film, the personnel involved in the production, and often some short, critical comments are included for each film. This dictionary is a companion volume to a…

  17. Spontaneity, Freedom, and First Philosophy: A Response to Peter Roberts.

    ERIC Educational Resources Information Center

    Joldersma, Clarence W.

    2001-01-01

    Contends that Paulo Freire's ethical agenda is situated in ontology, or more particularly, in the ontological vocation of humans. At the same time, his deepest motivation is an ethical one, seeking justice for the oppressed. Argues that these two factors-ontology and ethics-are in competition for the status of first philosophy in Freire's work.…

  18. Vygotsky on Education Primer. Peter Lang Primer. Volume 30

    ERIC Educational Resources Information Center

    Lake, Robert

    2012-01-01

    The "Vygotsky on Education Primer" serves as an introduction to the life and work of the Russian psychologist Lev Vygotsky. Even though he died almost eighty years ago, his life's work remains both relevant and significant to the field of education today. This book examines Vygotsky's emphasis on the role of cultural and historical context in…

  19. The Quest for Method: The Legacy of Peter Ramus

    ERIC Educational Resources Information Center

    Triche, Stephen; McKnight, Douglas

    2004-01-01

    Over the last 5 centuries, successive generations of educators have engaged in a reevaluation of curriculum and pedagogy in an effort to reveal the mechanisms that underlie the mysteries of the educational process. The current debate in the USA over the nature of pedagogical reform, particularly in terms of teacher accountability, high-stakes…

  20. The Peter Effect in Early Experimental Education Research

    ERIC Educational Resources Information Center

    Little, Joseph

    2003-01-01

    One of the signatures of scientific writing is its ability to present the claims of science as if they were "untouched by human hands." In the early years of experimental education, researchers achieved this by adopting a citational practice that led to the sedimentation of their cardinal method, the analysis of variance, and their standard for…

  1. The Video PATSEARCH System: An Interview with Peter Urbach.

    ERIC Educational Resources Information Center

    Videodisc/Videotext, 1982

    1982-01-01

    The Video PATSEARCH system consists of a microcomputer with a special keyboard and two display screens which accesses the PATSEARCH database of United States government patents on the Bibliographic Retrieval Services (BRS) search system. The microcomputer retrieves text from BRS and matching graphics from an analog optical videodisc. (Author/JJD)

  2. Charter School Primer. Peter Lang Primer. Volume 34

    ERIC Educational Resources Information Center

    Tryjankowski, Anne Marie

    2012-01-01

    The "Charter School Primer" presents an overview of public charter schools in the United States. The book discusses what charter schools are; the history of public charter school choice in the United States; the role of teachers, parents, boards, and unions in the charter school movement; and gives examples of innovations in education made…

  3. Spontaneous ionization to subatomic physics: Victor Hess to Peter Higgs

    NASA Astrophysics Data System (ADS)

    De Angelis, Alessandro

    2013-10-01

    The discovery of cosmic rays, a milestone in science, was based on the work by scientists in Europe and the New World. Many scientists that took part in this research a century ago were intrigued by the penetrating radiation and tried to understand the origin of it. Cosmic ray physics is at the foundations of modern particle physics, and some of the recent discoveries in particle physics find their roots in cosmic-ray physics.

  4. Bush's 2008 Budget: "Robbing Peter to Pay Pell"

    ERIC Educational Resources Information Center

    Brainard, Jeffrey

    2007-01-01

    A few days before President Bush officially released his 2008 budget, administration officials announced that it would contain a historic increase in the maximum Pell Grant. The increase in Pell Grants would be paid for by cutting subsidies for student loans, a step that experts predicted could induce lenders to offer fewer benefits to borrowers.…

  5. Robbing Peter to Pay Paul: The Case Against "Comparability"

    ERIC Educational Resources Information Center

    Walsh, Kate

    2007-01-01

    Two proposals in the bill currently circulating to reauthorize No Child Left Behind seem to be shoe-ins for making their way into federal law. The impetus behind both proposals is to help poor kids by making sure that districts spend as much money on them as gets spent on rich kids. Going against the grain, the National Council on Teacher Quality…

  6. Interfering with Capitalism's Spell: Peter Mclaren's Revolutionary Liminality

    ERIC Educational Resources Information Center

    Fassbinder, Samuel Day

    2006-01-01

    McLaren's recent (post-2000) writings promote a form of agency called "revolutionary critical pedagogy," and a type of agent, the "committed intellectual" (McLaren 2005b, p. 253-281). But one can find an earlier agent-type in McLaren's (1986) "Schooling as a Ritual Performance", the "liminal servant," that…

  7. Robbing Peter...Balancing Collection Development and Reference Responsibilities.

    ERIC Educational Resources Information Center

    Null, David G.

    1988-01-01

    Examines problems of librarians responsible for both collection development and reference services, including time demands, unclear supervisory lines, and misunderstanding of collection development. The discussion includes suggestions for improving this situation, e.g., formal reporting lines for both areas, increased communication among…

  8. Landscape by Moonlight: Peter Paul Rubens and Astronomy

    NASA Astrophysics Data System (ADS)

    Mendillo, M.

    2016-01-01

    In the last years of his life, Rubens (1577-1640) lived happily with his wife and children on his Het Steen estate. During this period he worked and reworked a painting that had special meaning to him—Landscape by Moonlight (1635-40), now at the Courtauld Gallery in London. After a highly successful career painting religious and secular portraits, allegories, and occasional landscapes, Rubens put an extraordinary amount of effort into this final landscape. He was well known as a person who would commit to memory ideas and themes that he would use in future works. This paper reviews Rubens' attention to the visualization of nature, his personal connections to Elsheimer, Galileo, and Peiresc, and explores his possible depiction of constellations recalled from memory and placed within the cloudy skies in his Landscape by Moonlight.

  9. Flavonoids and phenolic acids of Nepeta cataria L. var. citriodora (Becker) Balb. (Lamiaceae).

    PubMed

    Modnicki, Daniel; Tokar, Magdalena; Klimek, Barbara

    2007-01-01

    Luteolin 7-O-glucuronide, luteolin 7-O-glucurono-(1-->6)-glucoside, apigenin 7-O-glucuronide as well as free aglycones luteolin and apigenin have been isolated from lemon catnip herb (Nepeta cataria L. var citriodora). Luteolin 7-O-glucurono-(1-->6)-glucoside is probably a new compound, for the first time described. Two minor constituents of flavonoid fraction have been identified as apigenin 7-O-glucoside and luteolin 7-O-glucoside by means of HPLC method. The percentage of total flavonoids determined by use of spectrophotometric method was in the range from 0.30 to 0.46% of dry mass. In phenolic acid fraction, caffeic, rosmarinic and p-coumaric acids have been identified. Total amount of phenolic acids determined by spectrophotometric method was in the range of 0.75% to 1.4 % and the content of rosmarinic acid quantified by HPLC method fluctuated in the wide range from 0.06% to 0.15% depending on the sample. The results of the investigations showed that the composition of flavonoid compounds and phenolic acids in lemon catnip are similar to those in lemon balm (Melissa officinalis L.). The amount of flavonoids are similar in both plants, and the percentage of rosmarinic acid is about ten times lower in lemon catnip than in lemon balm. The presence of luteolin, apigenin and their glycosides, caffeic acid as well as the previously described terpenoids (ursolic acid, citral, nerol. geraniol) suggests the possibility of the use of lemon catnip herb as a constituent of phytopharmaceutical preparations with mild sedative, antispasmodic, antioxidative and antiinflammatory action. PMID:17695148

  10. 75 FR 68377 - Tamarac National Wildlife Refuge, Becker County, and Tamarac Wetland Management District, Minnesota

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... publishing a notice of intent on (72 FR 27587, May 16, 2007). For more information about the initial process... a notice of availability on (75 FR 39038, July 7, 2010). The 42,738-acre Tamarac NWR was established... Management District (WMD). Goals and objectives in the CCP describe how the agency intends to manage...

  11. COMMITTEES: SQM2004 Organising and International Advisory Committees

    NASA Astrophysics Data System (ADS)

    2005-06-01

    Organising Committee Jean Cleymans (Chairman) Zeblon Vilakazi Roger Fearick Peter Steinberg Rory Adams Bruce Becker Sarah Blyth Gareth de Vaux Heather Gray Mark Horner Nawahl Razak Artur Szostak Spencer Wheaton International Advisory Committee Federico Antinori Tim Hallman John Harris Tetsuo Hatsuda Ulrich Heinz Huan Z Huang Sonja Kabana Volker Koch Rob Lacey Jes Madsen Yasuo Miake Maurizio Morando Berndt Mueller Grazyna Odyniec Helmut Oeschler Apostolos Panagiotou Josef Pochodzalla Johann Rafelski Karel Safarik Jack Sandweiss Jürgen Schaffner-Bielich Georges Stephans Horst Stoecker Herbert Stroebele Thomas Ullrich Orlando Villalobos-Baillie Bill Zajc Joseph Zimanyi

  12. Estimated ground-water use in Becker, Clay, Douglas, Grant, Otter Tail, and Wilkin Counties, Minnesota, for 2030 and 2050

    USGS Publications Warehouse

    Winterstein, Thomas A.

    2007-01-01

    The estimated recharge to the Buffalo aquifer, Otter Tail surficial aquifer, and Pelican River sand-plain aquifer is 3,707, 51,000, and 4,900–8,900 Mgal/yr, respectively. The range of the estimated 2050 ground-water withdrawals from the Buffalo, Otter Tail surficial, and Pelican River sand-plain aquifers is 1,234–1,776 Mgal/yr from the Buffalo aquifer, 11,728–14,820 Mgal/yr from the Otter Tail surficial aquifer, and 3,385–4,298 Mgal/yr from the Pelican River sand-plain aquifer.

  13. Thomsen or Becker myotonia? A novel autosomal recessive nonsense mutation in the CLCN1 gene associated with a mild phenotype.

    PubMed

    Gurgel-Giannetti, Juliana; Senkevics, Adriano S; Zilbersztajn-Gotlieb, Dinorah; Yamamoto, Lydia U; Muniz, Viviane P; Pavanello, Rita C M; Oliveira, Acary B; Zatz, Mayana; Vainzof, Mariz

    2012-02-01

    We describe a large Brazilian consanguineous kindred with 3 clinically affected patients with a Thomsen myotonia phenotype. They carry a novel homozygous nonsense mutation in the CLCN1 gene (K248X). None of the 6 heterozygote carriers show any sign of myotonia on clinical evaluation or electromyography. These findings confirm the autosomal recessive inheritance of the novel mutation in this family, as well as the occurrence of phenotypic variability in the autosomal recessive forms of myotonia. PMID:22246887

  14. [Morphology of gametes in sea urchins from Peter the Great Bay, Sea of Japan].

    PubMed

    Drozdov, A L; Vinnikova, V V

    2010-01-01

    The fine structure of the gametes in six sea urchin species of the Sea of Japan was studied. The spermatozoons in Strongylocentrotus nudus, S. intermedius, Echinocardium cordatum, Scaphechinus mirabilis, Sc. grizeus and Echinarachnius parma are species-specific. The conical head and symmetrically disposed ring-shape mitochondrion are common to regular sea urchin sperm cells. S. nudus is characterized by the bulb-shaped head of the zoosperm; S. intermedius, by a bullet-shaped one. The zoosperm spearhead and small amount of postacrosome material are common to irregular sea urchins; the sperm width: length ratio varies for different species, with the highest for Sc. mirabilis. The zoosperm of Sc. griseus is characterized by two lipid drops in the cell center. Asymmetrical mitochondrion disposal is usual for E. parma. Actin filaments are found in the postacrosome material in the zoosperm of cordiform sea urchins. The differences in the fine structure of zoosperm in eurybiont species Ech. cordatum inhabiting the Sea of Japan and coastal areas of the Northeast Atlantic may bear record to the complex existence of species Ech. cordatum. The fine structure of zoosperm is unique for each of the studied families, Strongylocentrotidae, Scutellidae, and Loveniidae. The eggs of all the species are characterized by vitelline and tremelloid membranes. The vitelline membrane is formed by cytoplasm protrusions; the area between them is filled with fubrillary material. The tremelloid membrane is formed by fubrillary material associated with apical parts of microvilli of the vitelline membrane. The irregular sea urchins Sc. griseus, Sc. mirabilis and E. parma are characterized by chromatophores situated in the tremelloid membrane, with the highest abundance in Sc. mirabilis. PMID:20184121

  15. Epilogue to the Case of Peter: Was He a Survivor or a Schlemiel?

    ERIC Educational Resources Information Center

    Reap, Thomas Gerard, Jr.

    1991-01-01

    Responds to suggestions offered by previous two articles concerning the case of a young adult male with chronic back pain who was unable to work. Goes on to describe actual course that counseling took with this client and the outcomes of that counseling. Concludes by describing client's successful entry into field of robotics. (NB)

  16. Robbing Peter To Pay Paul: Resolving the Contradiction of Lifelong Learning.

    ERIC Educational Resources Information Center

    Gorard, Stephen

    2002-01-01

    Initial education has been the focus of policy, resulting in higher participation rates and attainment. However, adult rates of participation and qualification have received less attention and are decreasing. One solution might be to break the link between education and human capital investment and foster a vision of lifelong learning as valuable…

  17. Robbing Peter to Pay Paul: The Price of Standards-Driven Education

    ERIC Educational Resources Information Center

    Ingleby, Ewan

    2010-01-01

    This article presents research findings on mentoring within PCET ITT (Post-Compulsory Education and Training Initial Teacher Training). The research has identified that mentors and mentees consider that the role of the mentor is unclear. Moreover, mentors are unsure of the aims of PCET ITT programmes. The inconsistency of mentor training…

  18. Think Like Peter Senge: Applying His Laws of Systems Thinking to Identify Patterns That Shape Behavior

    ERIC Educational Resources Information Center

    O'Callaghan, William G., Jr.

    2004-01-01

    Realizing how difficult it is to pass tax issues today, many school boards with all good intentions place them on the ballot before the money is really needed. They do this so if the tax issues are not approved, they have another chance to get them passed before serious educational cuts have to be made. In states where school districts must rely…

  19. Treatment development for systemic Tetrahymena sp. infection in guppies, Poecilia reticulata Peters.

    PubMed

    Leibowitz, M Pimenta; Chettri, J Kumar; Ofir, R; Zilberg, D

    2010-06-01

    Antibacterial and antiparasitic agents and a cysteine protease inhibitor (E-64) were tested against Tetrahymena infection, a serious problem in guppy production worldwide. Chemicals were tested in vitro by a colorimetric assay for Tetrahymena survival. The most effective were niclosamide, albendazole and chloroquine, with 23%, 35% and 60% survival, respectively, following 2-h exposure to 100 ppm. Longer incubation periods resulted in greater reductions in survival. Niclosamide was further studied in vivo at different dosages, administered orally to Tetrahymena-infected guppies. Mortality rates were significantly lower in all treatment groups; in trial I, 30% and 33% mortality in 5 and 40 mg kg(-1) niclosamide-fed fish vs. 59% mortality in controls; in trial II, 35%, 13% and 10% in 50, 100 and 200 mg kg(-1) niclosamide-fed fish vs. 64% in controls. The effect of the cysteine protease inhibitor E64 was tested in tissue culture, by measuring histolytic activity of the parasite (Tet-NI) on a guppy-fin cell line, based on cell depletion. Tet-NI feeding activity was significantly reduced following pretreatment with E-64 relative to non-treated Tet-NI. E-64-pretreated Tet-NI was injected i.p. into guppies: recorded mortality rates were significantly lower (35%) than that in non-treated Tet-NI (60%), suggesting inhibition of the parasite's cysteine protease as a possible therapeutic approach. PMID:20298452

  20. Crowding Peter to Educate Paul: Lessons from a Class Size Reduction Externality

    ERIC Educational Resources Information Center

    Sims, David P.

    2009-01-01

    This paper examines an increase in upper elementary class sizes in California associated with the K-3 class size reduction program. I also use the variation in fourth and fifth grade class size generated by idiosyncratic first and second grade reductions required to meet program rules to identify a negative impact of larger class sizes on…

  1. 75 FR 49992 - Peter W.S. Grigg, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... * * * considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I ``may rely on any one...). However, under Agency precedent, neither of these findings is dispositive. See Edmund Chein, 72 FR 6580, 6590 n.22 (2007); Mortimer B. Levin, 55 FR 8209, 8210 (1990). Moreover, the evidence with respect...

  2. Is hospital patient care becoming safer? A conversation with Lucian Leape. Interview by Peter I. Buerhaus.

    PubMed

    Leape, Lucian

    2007-01-01

    According to Lucian Leape, patient safety in hospitals is improving, and it is now possible to get to a level of zero defects. Growing recognition of the need for team training, use of trigger tools, improving the competency of physicians, and full disclosure and compensation to injured patients exemplify positive developments. Yet formidable barriers remain, including separatism in how doctors, nurses, and pharmacists learn; inadequate instruction in communication and team-building skills; poorly developed quality and safety curricula; lack of leadership among CEOs and hospital boards; physician apathy; absence of effective systems for accountability; and failure to believe in the possibility of eliminating medical errors and injuries. PMID:17925308

  3. Handbook of Liquid Crystal Research (edited by Peter J. Collings and Jay S. Patel)

    NASA Astrophysics Data System (ADS)

    Dadmun, Mark

    1998-10-01

    Oxford University Press: New York, 1997. 600 pp. ISBN 0-19-508442-X. $195. Are you interested in liquid crystals? Do you want to know more about their chemistry and physics? Have you ever wondered how the liquid crystalline display (LCD) on your digital watch or calculator works? How does that simple black and white display relate to the more complex twisted nematic active matrix liquid crystal displays (TN-AMLCD) that are found in laptop computers and other portable displays? What is the difference between twisted nematics and supertwisted nematics? What is a polymer-stabilized liquid crystal and what kinds of displays can be made from them? How do small-molecule liquid crystals relate to polymeric liquid crystals? How do they get all those colors from the display on a laptop computer? What kind of electronics are needed to accomplish that feat?

  4. Counseling Latina/o Students from an Ecological Perspective: Working with Peter

    ERIC Educational Resources Information Center

    Cerezo, Alison; O'Neil, Maya E.; McWhirter, Benedict T.

    2009-01-01

    This case study describes the experiences of a Mexican American college student addressing difficulties with academic motivation and social adjustment to college. The authors present a counseling intervention that is ecologically focused and designed to help the student develop critical consciousness regarding ethnic and social class identity.…

  5. Thermophysical behavior of St. Peter sandstone: application to compressed air energy storage in an aquifer

    SciTech Connect

    Erikson, R.L.

    1983-12-01

    The long-term stability of a sandstone reservoir is of primary importance to the success of compressed air energy storage (CAES) in aquifers. The purpose of this study was to: develop experimental techniques for the operation of the CAES Porous Media Flow Loop (PMFL), an apparatus designed to study the stability of porous media in subsurface geologic environments, conduct experiments in the PMFL designed to determine the effects of temperature, stress, and humidity on the stability of candidate CAES reservoir materials, provide support for the CAES field demonstration project in Pittsfield, Illinois, by characterizing the thermophysical stability of Pittsfield reservoir sandstone under simulated field conditions.

  6. Analysis of the Papal Benediction Sign: The ulnar neuropathy of St. Peter.

    PubMed

    Futterman, Bennett

    2015-09-01

    The origin of the Papal Benediction Sign has been a source of controversy for many generations of medical students. The question has been whether the Papal Benediction Sign posture is the result of an injury to the median nerve or to the ulnar nerve. The increasingly popular use of online "chat rooms" and the vast quantities of information available on the internet has led to an increasing level of confusion. Looking in major anatomy texts, anatomy and board review books as well as numerous internet sites the answer remains unresolved. Through the analysis of functional anatomy of the hand, cultural and religious practices of the early centuries of the Common Era and church art a clear answer emerges. It will become apparent that this hand posture results from an ulnar neuropathy. PMID:26118346

  7. Journey of a Hero--Working with Chronic Back Pain: The Case of Peter.

    ERIC Educational Resources Information Center

    Reap, Thomas Gerard, Jr.

    1991-01-01

    Presents a case study of a young adult male suffering from chronic back pain who, because of that disability, has been unable to work for the past several years. Reviews the client's physical problems, family situation, and employment history. (NB)

  8. Merkel Cell Carcinoma: 27-Year Experience at the Peter MacCallum Cancer Centre

    SciTech Connect

    Hui, Andrew C.; Stillie, Alison L.; Seel, Matthew; Ainslie, Jill

    2011-08-01

    Purpose: To retrospectively evaluate the treatment outcome of patients with Merkel cell carcinoma after local and/or regional treatment. Methods and Materials: Patients presenting to our center between January 1980 and July 2006 with Merkel cell carcinoma and without distant metastases were reviewed. The primary endpoint was locoregional control. Secondary endpoints were distant recurrence, survival and treatment toxicity. Results: A total of 176 patients were identified. The median age was 79 years. The median follow-up was 2.2 years for all patients and 3.9 years for those alive at the last follow-up visit. The most common primary site was the head and neck (56%), and 62 patients(35%) had regional disease at presentation. The initial surgery to the primary tumor involved (wide) local excision in 140 patients and biopsy only in 28 patients (8 patients had no identifiable primary tumor); 33 patients underwent nodal surgery. Of the 176 patients, 165 (94%) underwent radiotherapy (RT) and 29 of them also underwent concurrent chemotherapy. The median radiation dose was 50 Gy (range, 18-60). Locoregional recurrence developed in 33 patients(19%), with a median interval to recurrence of 8 months. Distant metastases developed in 43 patients(24%). Age, primary tumor size, and RT (no RT vs. <45 Gy vs. {>=}45 Gy) were predictive of locoregional control on univariate analysis. However, only RT remained significant on multivariate analysis. The estimated 5-year actuarial rate for locoregional control, progression-free survival, and overall survival was 76%, 60%, and 45%, respectively. Conclusion: The locoregional control rate for Merkel cell carcinoma in our study was comparable to those from other series using combined modality treatment with RT an integral part of treatment.

  9. Mathematics performance and the role played by affective and background factors peter grootenboer and brian hemmings

    NASA Astrophysics Data System (ADS)

    Grootenboer, Peter; Hemmings, Brian

    2007-12-01

    In this article, we report on a study examining those factors which contribute to the mathematics performance of a sample of children aged between 8 and 13 years. The study was designed specifically to consider the potency of a number of mathematical affective factors, as well as background characteristics (viz., gender, ethnicity, and socioeconomic status), on children's mathematics performance. Data were collected by surveying the children and drawing on performance ratings from their teachers. A correlation analysis revealed that the relationships between the respective dispositional and background variables with mathematics performance were significant and in the direction as predicted. Moreover, the findings from a logistic regression showed that a combination of these variables was able to appropriately classify students who either were below-average or above-average mathematics performers. We pay particular attention to the influence of certain dispositions with respect to mathematics performance and conclude by detailing the implications of the study for teachers and researchers.

  10. Great Mentors: Robert Jervis, Bruce Bueno de Mesquita, and Peter Katzenstein

    ERIC Educational Resources Information Center

    McDermott, Rose

    2010-01-01

    I have been extremely blessed in my life to have benefitted from some amazing mentors and friends in both psychology (most notably, Amos Tversky, Phil Zimbardo, and Leda Cosmides) and political science. Inspired by the occasion of Robert Jervis' festschrift, which importantly does not signal his imminent retirement, I was prompted to take…

  11. On Politics and Puppetry: An Interview with Peter Schumann of Bread and Puppet Theater.

    ERIC Educational Resources Information Center

    Schumann, Peter

    2001-01-01

    The founder of Bread and Puppet Theater discusses the use of puppetry and theater arts to build community, educate the public about environmental and sociopolitical issues, and provide a setting for group consciousness raising; grassroots reclaiming of art as part of everyday life; and ceremony as a powerful element of performance and as part of…

  12. The Peter Brojde Lung Cancer Centre: a model of integrative practice

    PubMed Central

    Grossman, M.; Agulnik, J.; Batist, G.

    2012-01-01

    Background The generally poor prognosis and poor quality of life for lung cancer patients have highlighted the need for a conceptual model of integrative practice. Although the philosophy of integrative oncology is well described, conceptual models that could guide the implementation and scientific evaluation of integrative practice are lacking. Purpose The present paper describes a conceptual model of integrative practice in which the philosophical underpinnings derive mainly from integrative oncology, with important contributions from Traditional Chinese Medicine (tcm) and the discipline of nursing. The conceptual model is described in terms of its purpose, values, concepts, dynamic components, scientific evidence, clinical approach, and theoretical underpinnings. The model argues that these components delineate the initial scope and orientation of integrative practice. They serve as the needed context for evaluating and interpreting the effectiveness of clinical interventions in enhancing patient outcomes in lung cancer at various phases of the illness. Furthermore, the development of relevant and effective integrative clinical interventions requires new research methods based on whole-systems research. An initial focus would be the identification of interrelationship patterns among variables that influence clinical interventions and their targeted patient outcomes. PMID:22670104

  13. No Child Left Behind Primer. Second Printing. Peter Lang Primer Volume 11

    ERIC Educational Resources Information Center

    Hess, Frederick M.; Petrilli, Michael J.

    2007-01-01

    No Child Left Behind (NCLB) is the single most influential piece of federal education legislation in American history, and Hess and Petrilli provide a concise yet comprehensive look at this important and controversial act. Signed into law in 2002, NCLB seeks to ensure that all American students are proficient in math, reading, and science by 2014.…

  14. Communitas, Ritual, and Sustainability in Peter Senge's Presence: Human Purpose and the Field of the Future

    ERIC Educational Resources Information Center

    Collins, Shawn T.

    2005-01-01

    "Presence" suggests that adapting the experiences of leading innovators may address a nightmare scenario of environmental destruction, a growing divide between the rich and poor, and escalating violence around the world. Innovation occurs by transforming sensing to identify limitations in existing solution sets, transforming perception to envision…

  15. PETER: A Hardware Simulator for the Test Mass-GRS System of LISA Pathfinder

    NASA Astrophysics Data System (ADS)

    Marconi, L.; Stanga, R.; Bassan, M.; De Marchi, F.; Pucacco, G.; Visco, M.; Di Fiore, L.; De Rosa, R.; Garufi, F.

    2013-01-01

    Each LISA PathFinder test mass (TM) will be sensitive to forces along all its 6 Degrees of Freedom (DoFs). Extensive ground testing is required in order to evaluate the influence of cross-talks from the read-out and actuator channels. In the INFN laboratory of Firenze we have developed a facility for a good representation of the free fall conditions of the TM on flight. A hollow replica of a TM hanging from a double torsion pendulum can move inside a Gravitational Reference Sensor (GRS) with quasi free fall condition on two Dofs, in the frequency band (0.1 ÷ 100)mHz. On both DoFs, the target residual accelerations (yet to be achieved) at the low end frequency range are ≤ 3 × 10-13ms-2, limited by the thermal noise of the fibres. At higher frequencies, the sensitivity is limited by the readout noise of the readout, a replica of the flight electronics. After a long commissioning, we are now in operating conditions, and can carry out a series of experiments to better qualify the interaction between TM and GRS. In this paper we will show some significant qualification measurements and a first scientific measurements, i.e. the measurement and compensation of the DC bias in the GRS using two independent channels, as well as a measurement of the residual acceleration of the translational DoF, with the feedback loop closed on the rotational one, and viceversa.

  16. A Reflective Interview with Marcia Gentry and Scott Peters: The Hope Scale

    ERIC Educational Resources Information Center

    Greathouse, Dan; Shaughnessy, Michael F.; Gentry, Marcia; Peters, Scott

    2015-01-01

    The Hope Scale is an 11-item teacher-rating instrument designed to help identify academic and social components of giftedness. It provides insights from teachers who work with students on a daily basis, which may differ from the type of information yielded through achievement and ability tests. The Hope Scale development was made possible by the…

  17. Two new cytotypes reinforce that Micronycteris hirsuta Peters, 1869 does not represent a monotypic taxon

    PubMed Central

    2013-01-01

    Background The genus Micronycteris is a diverse group of phyllostomid bats currently comprising 11 species, with diploid number (2n) ranging from 26 to 40 chromosomes. The karyotypic relationships within Micronycteris and between Micronycteris and other phyllostomids remain poorly understood. The karyotype of Micronycteris hirsuta is of particular interest: three different diploid numbers were reported for this species in South and Central Americas with 2n = 26, 28 and 30 chromosomes. Although current evidence suggests some geographic differentiation among populations of M. hirsuta based on chromosomal, morphological, and nuclear and mitochondrial DNA markers, the recognition of new species or subspecies has been avoided due to the need for additional data, mainly chromosomal data. Results We describe two new cytotypes for Micronycteris hirsuta (MHI) (2n = 26 and 25, NF = 32), whose differences in diploid number are interpreted as the products of Robertsonian rearrangements. C-banding revealed a small amount of constitutive heterochromatin at the centromere and the NOR was located in the interstitial portion of the short arm of a second pair, confirmed by FISH. Telomeric probes hybridized to the centromeric regions and weakly to telomeric regions of most chromosomes. The G-banding analysis and chromosome painting with whole chromosome probes from Carollia brevicauda (CBR) and Phyllostomus hastatus (PHA) enabled the establishment of genome-wide homologies between MHI, CBR and PHA. Conclusions The karyotypes of Brazilian specimens of Micronycteris hirsuta described here are new to Micronycteris and reinforce that M. hirsuta does not represent a monotypic taxon. Our results corroborate the hypothesis of karyotypic megaevolution within Micronycteris, and strong evidence for this is that the entire chromosome complement of M. hirsuta was shown to be derivative with respect to species compared in this study. PMID:24359225

  18. Peter and the Monolith: A Psychoanalytic Study of a Case of Writer's Block.

    ERIC Educational Resources Information Center

    Tingle, Nick

    1998-01-01

    Argues that: (1) the disturbing effects of writer's block the student experienced were the result of self-disintegration; (2) the student's cognitive powers were devoted to a defensive stabilization of the self; (3) the defining qualities of his writing were a product of his psychological configuration; and (4) his tendency toward narcissistic…

  19. Effect of cadmium on blood of tilapia, Oreochromis mossambicus (Peters), during prolonged exposure

    SciTech Connect

    Ruparelia, S.G.; Verma, Y.; Saiyed, S.R. ); Rawal, U.M. )

    1990-08-01

    Cadmium is recognized as one of the most hazardous environmental pollutants and is toxic to many living organisms. Experimental and environmental exposure to cadmium has been reported to cause disease in humans and other mammals. Recent reviews on cadmium have reported on acute and subacute effects on fish, mechanisms of toxicity, the role of toxicity modifying factors and various sublethal effects, i.e., hematological and biochemical disorders. However, very little information is available on the subacute effects of cadmium on fish blood exposed in hard water. The present investigation, therefore, was carried out to observe the effects of cadmium on the blood of tilapia (Oreochromis mossambicus) in hard and alkaline water to determine whether cadmium causes changes in blood of fish kept in hard water in the same way it causes changes in blood of fish kept in soft water.

  20. Reconsidering Schwab's Practicals: A Response to Peter Hlebowitsh's Generational Ideas in Curriculum: A Historical Triangulation

    ERIC Educational Resources Information Center

    Westbury, Ian

    2005-01-01

    This article explores the place of Ralph Tyler and Joseph Schwab in the history of curriculum studies, and educational theory more broadly. I argue that most analyses of both Schwab's and Tyler's work are built not on their own life-projects and writings, but developed from blinkered readings of a narrow range of their writings selected to meet…

  1. R.S. Peters and Jurgen Habermas: Presuppositions of Practical Reason and Educational Justice

    ERIC Educational Resources Information Center

    Martin, Christopher

    2009-01-01

    The contribution of philosophical ethics to the development of a just conception of education becomes increasingly complex under modern conditions of democratic pluralism. This is because the justification of moral policies for education faces the skeptical challenge of showing how the substantive moral principles upon which a policy rests do not…

  2. Peter Block's Flawless Consulting and the Homunculus Theory: Within Each Person Is a Perfect Consultant.

    ERIC Educational Resources Information Center

    Ross, Gloria J.

    1993-01-01

    Notes that Block (1981) saw consultant authenticity as significant to process of consulting and believed that, as consultant acknowledged feelings and thoughts when they surfaced, client commitment and trust would develop. Adds that Block has defined five phases to consulting and detailed work that must be completed in each phase to provide…

  3. Peter McLaren & the 3 R's: Reflection, Resistance and Revolution

    ERIC Educational Resources Information Center

    Gabbard, David

    2006-01-01

    In this article David Gabbard describes his first meeting with McLaren and his wife in 1989. Gabbard notes that although he had read some of McLaren's work, particularly some of his early collaborations with Henry Giroux, who had helped bring McLaren to Miami from Canada, no amount of reading, could have prepared him for meeting McLaren…

  4. Improve Your Marketing Results by Asking Peter F. Drucker's "Five Most Important Questions."

    ERIC Educational Resources Information Center

    Rossum, Constance; Baum, Geoffrey

    2001-01-01

    This case study demonstrates how the Office of Marketing & Public Relations at Claremont McKenna College used five "Drucker Tool" questions to improve marketing's image on campus and awareness of the college among key constituencies. It concludes with a reevaluation of the initial marketing strategy based on the growing importance of the Internet…

  5. The pornographic anatomy book? The curious tale of the Anatomical Basis of Medical Practice.

    PubMed

    Halperin, Edward C

    2009-02-01

    Studying the history of medical education helps teach us that medicine is a social activity that occurs in the context of social mores and customs. In 1971, a major new anatomy textbook aimed at first-year medical students was published. The Anatomical Basis of Medical Practice, written by Professors R. Frederick Becker, James S. W. Wilson, and John A. Gehweiler, emphasized surface anatomy, embryology, and radiographic anatomy. At multiple places in the text, the authors used sexually suggestive and "cheeky" comments about women. A small fraction of the illustrations were stylized, posed female nude photographs purchased from California photographer Peter Gowland. These photographs, of a type typically seen in Playboy centerfolds or "pin-up girl" calendars, produced a firestorm of controversy. The book was criticized in the press and in reviews in scholarly journals, and a boycott was organized by the Association of Women in Science. The publisher received negative feedback from consumers, and the book was withdrawn from the market. The book is now a minor collector's item. Professors Becker and Wilson vigorously responded. They laid blame for the debacle on the publisher and also claimed they were the victims of a witch hunt by feminists. The Anatomical Basis of Medical Practice appeared as the women's movement became part of the American popular consciousness. It was also an era in which the public began to grapple with how to define pornography. Professor Becker and his coauthors thought that they were writing a witty, engaging, and funny book. Their detractors thought the book denigrated women. PMID:19174685

  6. A HindIII polymorphism detected by cDMD 4-5a at the DMD locus in a family with Becker muscular dystrophy

    SciTech Connect

    Gibb, M.F.; Greenberg, C.R.; Carson, N.L.

    1994-09-01

    Deletions within the dystrophin gene can be detected by hybridizing a series of cDNA probes to HindIII-digested DNA, with the absence of one or more fragments indicating the presence of a deletion. However, incorrect interpretations can be made if the absence of a fragment is due to a polymorphism rather than a deletion. Otto and Rothbery reported that the 5.2 kb fragment detected by cM 4-5a could be resolved, with extended electrophoresis, into two fragments estimated to be 5.2 and 5.15 kb in size. They concluded that the extra fragment of this doublet appears to be polymorphic, inherited in a Mendelian dominant fashion. The mother, who is an obligate carrier of BMD, does not have the upper fragment as is the case for her normal and affected sons. The father, who clinically has no evidence of neuromuscular disease, does have the upper fragment as do all their daughters. Given a dominant pattern of inheritance, the daughters should be heterozygous. Analysis of one grandson, who was predicted to have inherited the grandpaternal dystrophin gene, showed that he did have the upper fragment, consistent with our conclusions. To date, we have been unable to analyze a grandson that has inherited the grandmaternal allele; however, presuably he would not have the upper fragment of this doublet. We conclude that there likely is a dominant HindIII polymorphism detected with the cDMD 4-5a probe at the DMD locus. Population studies will be required to determine the frequency of this polymorphism; however, it should be noted that absence of the upper fragment of this doublet in a male with BMD/DMD does not necessarily correspond to the presence of a deletion.

  7. ChemSkill Builder 2000, Version 6.1 [CD-ROM] (by James D. Spain and Harold J. Peters)

    NASA Astrophysics Data System (ADS)

    Keeney-Kennicutt, Reviewed By Wendy L.

    2000-07-01

    One of the major challenges for faculty teaching general chemistry is how to encourage students to practice solving problems. We know that for students to develop chemical intuition and problem-solving skills, they must "get their hands dirty" as they decipher and unravel problems inherent to our discipline. One tool that I've used since its release in 1996 is the ChemSkill Builder, an electronic homework package. The latest version, ChemSkill Builder (CSB) 2000, version 6.1, is an excellent, effective integration of teaching and testing most quantitative and conceptual learning objectives in an interactive way. It is inexpensive and easy to use for both students and faculty. The CSB 2000 package of personalized problem sets, specifically designed to complement most general chemistry courses, is a program on CD-ROM for PC Windows users (3.1, 95, or 98), with more than 1500 questions and a 3 1/2-in. record-management disk. There is a separate grade-management disk for the instructor. It has 24 gradable chapters, each with 5 or 6 sections, plus two new chapters that are not graded: Polymer Chemistry and an Appendix of Chemical Skills. Each section begins with a short review of the topic and many have interactive explanations. If students miss an answer, they are given a second chance for 70% credit. If they still miss, the worked-out solution is presented in detail. Students can work each section as many times as they wish to improve their scores. Periodically, the students download their data directly into a PC set up by the instructor. The data can be easily converted into an ASCII file and merged with a spreadsheet. The use of CD-ROM solves the sporadic problems associated with previous versions on 3 1/2-in. disks: software glitches, failed disks, and system incompatibilities. The quality and number of graphics and interactive exercises are much improved in this latest version. I particularly enjoyed the interactive explanations of significant figures and dimensional analysis in Sections 2.3 and 2.5, the pH meter simulation in Section 18.3, the Geiger counter simulation in Section 23.5, and the new periodic table game in Appendix A. I informally polled my Fall 1999 students on their midsemester impressions of the ChemSkill Builder, version 5.1--the previous version. The preliminary results in Table 1 show an overall acceptable rating of 3.45. Note that 51% of the students thought that incorporating the CSB into the syllabus was good to very good, compared to only 16% who gave negative responses. Positive comments included "a great tool to study for the test" and "it shows how to work out the problems". The major negative comment was that the CSB was too time-consuming because the acceptable answer had to include the right number of significant figures and the correct unit--sexactly what an instructor wants the student to learn. Interestingly, the scores given appeared to be independent of the students' midterm grades, suggesting that acceptance of this product might be linked to a specific learning style. When I compared my students' responses to their Keirsey temperaments in Table 2, the ChemSkill Builder appealed somewhat more to the students who like activity, entertainment and immediate feedback (SP) or who enjoy technology and constant success experiences (NT) than to the students who prefer more group interactions (NF) or who need more structure (SJ). At the semester's end, the students were asked again to rate the ChemSkill Builder, and 97% of 155 responses either agreed (28%) or strongly agreed (69%) that it proved helpful in learning course material. Moreover, 99% thought that I should continue to incorporate the ChemSkill Builder in future courses. To summarize, the ChemSkill Builder 2000, version 6.1, will be an excellent tool for augmenting the learning process in the general chemistry classroom.

  8. Functional structure of laminated microbial sediments from a supratidal sandy beach of the German Wadden Sea (St. Peter-Ording)

    NASA Astrophysics Data System (ADS)

    Bühring, Solveig I.; Kamp, Anja; Wörmer, Lars; Ho, Stephanie; Hinrichs, Kai-Uwe

    2014-01-01

    Hidden for the untrained eye through a thin layer of sand, laminated microbial sediments occur in supratidal beaches along the North Sea coast. The inhabiting microbial communities organize themselves in response to vertical gradients of light, oxygen or sulfur compounds. We performed a fine-scale investigation on the vertical zonation of the microbial communities using a lipid biomarker approach, and assessed the biogeochemical processes using a combination of microsensor measurements and a 13C-labeling experiment. Lipid biomarker fingerprinting showed the overarching importance of cyanobacteria and diatoms in these systems, and heterocyst glycolipids revealed the presence of diazotrophic cyanobacteria even in 9 to 20 mm depth. High abundance of ornithine lipids (OL) throughout the system may derive from sulfate reducing bacteria, while a characteristic OL profile between 5 and 8 mm may indicate presence of purple non-sulfur bacteria. The fate of 13C-labeled bicarbonate was followed by experimentally investigating the uptake into microbial lipids, revealing an overarching importance of cyanobacteria for carbon fixation. However, in deeper layers, uptake into purple sulfur bacteria was evident, and a close microbial coupling could be shown by uptake of label into lipids of sulfate reducing bacteria in the deepest layer. Microsensor measurements in sediment cores collected at a later time point revealed the same general pattern as the biomarker analysis and the labeling experiments. Oxygen and pH-microsensor profiles showed active photosynthesis in the top layer. The sulfide that diffuses from deeper down and decreases just below the layer of active oxygenic photosynthesis indicates the presence of sulfur bacteria, like anoxygenic phototrophs that use sulfide instead of water for photosynthesis.

  9. Surveying on the biologic behaviors of Hemiscorpius lepturus Peters 1861, scorpion in laboratory (Khuzestan, Iran) (Scorpions: Hemiscorpiidae).

    PubMed

    Dehghani, Rouhullah; Khamehchian, Tahereh; Miranzadeh, Mohammad Bagher

    2007-09-15

    This descriptive research was conducted so as to find and distinguish the sex of H. lepturus based on 107 dead specimens in the 70% ethyl alcohol and exact decision on their species using a criterion considering all morphological parameters and by the use of stereo microscope. Their biologic behaviors, 50 H. lepturus specimens which were fed and kept alive in capped bottles were studies while their way of shedding and number of newly-born young were also investigated under laboratory conditions in the process. The research revealed that in 107 H. lepturus specimens, 27 specimens (23%) were male and 80 ones (77%) were female. The results gained from 50 scorpions kept in the laboratory showed that only 10 cases (20%) had shed. Duration of emergence varies in each young from 10-20 min and delivery lasts approximately for 4-6 h. The average number of the young born was 24.3 in each delivery. It was concluded that the time of delivery and shedding in H lepturus is definitely fixed during the year and the number ofpectine denticles and length of the tail can be used to differentiate male and female H. lepturus. PMID:19090105

  10. Analyses and description of soil samples from Mountain Lake and Peters Mountain Wilderness Study areas, Virginia and West Virginia

    USGS Publications Warehouse

    Motooka, J.M.; Curtis, Craig A.; Lesure, Frank Gardner

    1978-01-01

    Semiquantitative emission spectrographic analyses for 30 elements and atomic absorption analysis for zinc on 98 soil samples are reported here in detail. Location for all samples are in Universal Transverse Mercator (UTM) coordinates. A few samples of soil developed on Lower Devonian sandstone and chert contain more barium and zinc than soils on other formations but do not suggest the occurrence of economic concentrations of either element.

  11. A new scorpion species of genus Diplocentrus Peters, 1861 (Scorpiones: Diplocentridae) endemic to Islas de la Bahia, Honduras.

    PubMed

    Sagastume-Espinoza, Kevin O; Longhorn, Stuart J; Santibáñez-López, Carlos E

    2015-07-01

    Three species of genus Diplocentrus are found in north-northwestern Honduras. These species represent the southern east limits of Diplocentrus' distribution. In recent years, a broad survey of arachnids in Honduras has yielded a collection of several specimens of an undescribed species from two islands in northern Honduras. This new species represents the second species of the genus inhabiting an island. The present contribution describes this new species, and compares it against its most similar relatives. A dichotomous key for the identification of the species of Diplocentrus in Honduras is also included. PMID:26026575

  12. The nymph of Gilliesia Peters & Edmunds, 1970 (Ephemeroptera: Leptophlebiidae), with description of a new species from Thailand.

    PubMed

    Boonsoong, Boonsatien; Sartori, Michel

    2015-01-01

    The new species Gilliesia ratchaburiensis sp. nov. is described based on male and female imagos (some of them reared from nymphal stages), nymphs and eggs collected in western Thailand. The nymph of Gilliesia, which is described for the first time, has bifid gills, a dense patch of setae on the ventral side of the glossae, no posterolateral spines on abdominal segment VIII, maxillary palpi 3-segmented and very reduced maxillary canines. Compared to congeners, the male imagos of the new species have penis lobes more straight and with the apical portion bent laterally but not ventrally, and female abdominal sternum 9 with a U-shaped, deep, median cleft. Phylogenetically, Gilliesia seems to be more similar to Dipterophlebiodes than to Habrophlebiodes and other Leptophlebiinae. The present finding in Thailand expands the distribution of Gilliesia in tropical Southeast Asia. PMID:26249992

  13. Reply to 'Comments on upscaling geochemical reaction rates usingpore-scale network modeling' by Peter C. Lichtner and Qinjun Kang

    SciTech Connect

    Li, Li; Peters, Catherine A.; Celia, Michael A.

    2006-05-03

    Our paper "Upscaling geochemical reaction rates usingpore-scale network modeling" presents a novel application of pore-scalenetwork modeling to upscale mineral dissolution and precipitationreaction rates from the pore scale to the continuum scale, anddemonstrates the methodology by analyzing the scaling behavior ofanorthite and kaolinite reaction kinetics under conditions related to CO2sequestration. We conclude that under highly acidic conditions relevantto CO2 sequestration, the traditional continuum-based methodology may notcapture the spatial variation in concentrations from pore to pore, andscaling tools may be important in correctly modeling reactive transportprocesses in such systems. This work addresses the important butdifficult question of scaling mineral dissolution and precipitationreaction kinetics, which is often ignored in fields such as geochemistry,water resources, and contaminant hydrology. Although scaling of physicalprocesses has been studied for almost three decades, very few studieshave examined the scaling issues related to chemical processes, despitetheir importance in governing the transport and fate of contaminants insubsurface systems.

  14. Delineation of recharge areas for selected wells in the St. Peter-Prairie du Chien-Jordan Aquifer, Rochester, Minnesota

    USGS Publications Warehouse

    Delin, G.N.; Almendinger, James Edward

    1991-01-01

    Hydrogeologic mapping and numerical modeling were used to delineate zones of contribution to wells, defined as all parts of a ground-water-flow system that could supply water to a well. The zones of contribution delineated by use of numerical modeling have similar orientation (parallel to regional flow directions) but significantly different areas than the zones of contribution delineated by use of hydrogeologic mapping. Differences in computed areas of recharge are attributed to the capability of the numerical model to more accurately represent (1) the three-dimensional flow system, (2) hydrologic boundaries like streams, (3) variable recharge, and (4) the influence of nearby pumped wells, compared to the analytical models.

  15. Delineation of recharge areas for selected wells in the St. Peter-Prairie du Chien-Jordan aquifer, Rochester, Minnesota

    USGS Publications Warehouse

    Delin, G.N.; Almendinger, James Edward

    1993-01-01

    Hydrogeologic mapping and numerical modeling were used to delineate zones of contribution to wells, defined as all parts of a ground-water-flow system that could supply water to a well. The zones of contribution delineated by use of numerical modeling have similar orientation (parallel to regional flow directions) but significantly different areas than the zones of contribution delineated by use of hydrogeologic mapping. Differences in computed areas of recharge are attributed to the capability of the numerical model to more accurately represent (1) the three-dimensional flow system, (2) hydrologic boundaries such as streams, (3) variable recharge, and (4) the influence of nearby pumped wells, compared to the analytical models.

  16. The Educational and Political Significance of the New Social Media: A Dialogue with Linda Herrera and Michael A. Peters

    ERIC Educational Resources Information Center

    Herrera, Linda; Peters, Michael A.

    2011-01-01

    The year 2010 was named the Year of Social Media, a technology of communication and for creating and exchanging "User Generated Content". The year 2010 also marked the start of the Arab revolts where, in Tunisia and Egypt, social media served as a critical platform for expressing dissent, organizing, and providing citizen media accounts of events.…

  17. The Little Red Hen Meets Peter Rabbit: Enhancing the Reading Comprehension and Social Understanding of Young Students with Language Disabilities.

    ERIC Educational Resources Information Center

    Richards, Janet C.; And Others

    1997-01-01

    This article describes the use of holistic literacy lessons about story characters to teach reading comprehension to students with language disabilities. Different educational strategies for involving students in the emotional and social lives of story characters are discussed, including creating character report cards, holding press conference…

  18. Peters' Non-Instrumental Justification of Education View Revisited: Contesting the Philosophy of Outcomes-based Education in South Africa.

    ERIC Educational Resources Information Center

    Waghid, Yusef

    2003-01-01

    Argues that Outcomes-based Education is conceptually trapped in an instrumentally justifiable view of education. Discusses that the process of specifying outcome sin educational discourse lends itself to manipulation and control thereby making the idea of Outcomes-based Education impoverished. Argues for education through rational reflection and…

  19. Hemoglobin and hematocrit values in the fish Oreochromis mossambicus (Peters) after short term exposure to copper and mercury

    SciTech Connect

    Cyriac, P.J.; Antony, A.; Nambisan, P.N.K. )

    1989-08-01

    Hematology is used as an index of health status in a number of fish species. Hematological changes have been detected following different types of stress conditions like exposure to pollutants, diseases, hypoxia, etc. Copper and mercury are two known aquatic pollutants. Though copper is an essential micro-nutrient, it is highly toxic at high concentrations. Mercury has no biological function to serve and causes serious impairment in the metabolic and physiological functions of the body. In this paper hematocrit and hemoglobin (Hb) values in the fish Oreochromis mossambicus separately exposed to two different sublethal concentrations of copper and mercury for a period of 168 h are reported.

  20. Bühler revisited in times of war--Peter R. Hofstätter's The Crisis of Psychology (1941).

    PubMed

    Gundlach, Horst

    2012-06-01

    During World War II in 1941, the psychologist P. R. Hofstätter added an article to the debate on the crisis of psychology in a distinctly Nazi academic journal. After introducing Hofstätter and the journal, the core elements of his diagnosis and therapy recommendation beneath the National-Socialist-verbiage will be expounded. Hofstätter, a student of Karl Bühler's, ties on to his teacher's crisis well-known publication, but perceives the crisis in a broader perspective and connects it to the decline of theology and of pastoral guidance. Hofstätter's central, new aspect is the practice of psychology without which he sees it doomed. A central feature of psychological practice should be secular, non-therapeutic guidance of individuals. Various contextual facets are illuminated, Hofstätter's thwarted attempts to get a university position, the recent establishment of psychology in Germany as a discipline teaching professionals, the abolition of German military psychology, the battle for the Berlin university chair of Wolfgang Köhler. PMID:22520199

  1. Changes in selected biochemical parameters in the kidney and blood of the fish, Tilapia mossambica (Peters), exposed to heptachlor

    SciTech Connect

    Radhaiah, V.; Girija, M.; Rao, K.J.

    1987-12-01

    Pesticides used in pest control programs seem to produce many physiological and biochemical changes in fresh water organisms by influencing the activities of several enzymes. Alterations in the chemical composition of the natural aquatic environment usually effect behavioral and physiological systems of the inhabitants, particularly of the fish. Although some data are available on the effects of different pesticides on the biochemical aspects of fish gill, data on heptachlor toxicity on T. mossambica kidney are lacking. Therefore, an attempt has been made to observe certain biochemical paramets of fish, T. mossambica under heptachlor intoxication. Investigation of this nature is useful in understanding the orientation of biochemical changes during sublethal toxicity to ascertain the degree of intensity of the toxicity of heptachlor on the kidney.

  2. Genetics Home Reference: phosphoribosylpyrophosphate synthetase superactivity

    MedlinePlus

    ... Sources for This Page Ahmed M, Taylor W, Smith PR, Becker MA. Accelerated transcription of PRPS1 in ... 11):7482-8. Citation on PubMed Becker MA, Smith PR, Taylor W, Mustafi R, Switzer RL. The ...

  3. Castagna, M., M. W. Becker, and A. Bellin (2011), Joint estimation of transmissivity and storativity in a bedrock fracture, Water Resour. Res., 47, W09504, doi:10.1029/2010WR009262.

    SciTech Connect

    Castagna, M; Becker, M W; Bellin, A

    2011-11-30

    The spatial variability of transmissivity (T) and storativity (S) in a sandstone bedding plane fracture was investigated through field and numerical hydraulic tomography experiments. Cross-hole pumping tests were conducted in a single subhorizontal bedrock fracture, thereby constraining the problem to two dimensions. A Bayesian method implementing pilot points was used to invert the drawdown, under the hypothesis that T and S are independent random space functions, where integral scale, mean, and variance of the random fields were parameters of inversion in addition to pilot point values. An ensemble of 20 Monte Carlo realizations was created for each model scenario. Inversion of the measured cross-hole drawdown resulted in spatially variable T and S fields. To determine the accuracy of the method, a suite of synthetic inversions modeled after the field site were also conducted. The synthetic experiments demonstrate that the assumed spatial structure of S influences the accuracy of both the T and S inversions. When the S field is spatially heterogeneous and is assumed to be heterogeneous in the inversion, a consistent representation of the T and S fields is obtained. When the S field is spatially heterogeneous but is assumed to be homogeneous in the inversion, a consistent representation of the T field is still obtained, but the S field is entirely misrepresented; if the S field is actually homogeneous but assumed to be heterogeneous, a poor representation of the T and S fields is obtained along with high uncertainty in the inversion statistics of confidence.

  4. Strategies for Enhancing Adolescents' Health through Music Media. A Commentary on "Popular Music in Early Adolescence" by Peter G. Christensen and Donald F. Roberts.

    ERIC Educational Resources Information Center

    Flora, June A.

    The primary purpose of this paper is to describe strategies for enhancing the health behavior of adolescents and their families through increasing the healthfulness of the media environment, particularly radio or the music industry. A second goal is to briefly describe research that would enhance understanding of the healthfulness of the media…

  5. A resolution expressing condolences to the family of Abdul-Rahman Peter Kassig and condemning the terrorist acts of the Islamic State of Iraq and the Levant.

    THOMAS, 113th Congress

    Sen. Donnelly, Joe [D-IN

    2014-12-10

    12/10/2014 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (consideration: CR S6581; text as passed Senate: CR S6543) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  6. EDITORIAL: Nobel Prize in Physiology or Medicine 2003 awarded to Paul Lauterbur and Peter Mansfield for discoveries concerning magnetic resonance imaging

    NASA Astrophysics Data System (ADS)

    Leach, Martin O.

    2004-02-01

    The award of the Nobel Prize in Physiology or Medicine recognizes discoveries concerning the use of magnetic resonance to visualize different structures. The Assembly's decision to recognize the discoveries underpinning efficient spatial mapping of biological properties reflects the singular importance of imaging to the medical application of this technique. Without this, abnormalities in morphology cannot be recognized. Equally, the wealth of physiological information that can be obtained by manipulation of the magnetic resonance signal is of little value unless localized to identified organs, pathology or areas of tissue. Based on these early discoveries, a wide range of imaging and measurement techniques, together with enabling instrumentation, have been developed over the last 30 years. Commercial equipment became available in the early 1980s, and some 60 million MRI examinations are now performed each year. The power of the technique, and the range of applications, continues to develop rapidly. The full text of this editorial is given in the PDF file below.

  7. Pre-test geological and geochemical evaluation of the Caprock, St. Peter Sandstone and formation fluids, Yakley Field, Pike County, Illinois

    SciTech Connect

    Not Available

    1983-03-01

    The goal of these studies is to ensure long-term stable containment of air in the underground reservoirs used in conjunction with compressed air energy storage (CAES) plants. The specific objective is to develop stability criteria and engineering guidelines for designing CAES reservoirs in each of the three major reservoir types, including aquifers, salt cavities, and mined hard rock caverns. This document characterizes the geologic nature of porous media constituents native to the aquifer field test site near Pittsfield, Illinois. The geologic samples were subjected to geochemical evaluations to determine anticipated responses to cyclic air injection, heating and moisture - conditions typical of an operating CAES reservoir. This report documents the procedures used and results obtained from these analyses.

  8. Let Peter Rabbit Play in the Garden: Using Beatrix Potter's Work to Integrate Ecological Literacy into Montessori Classrooms

    ERIC Educational Resources Information Center

    Johnson, Kelly

    2015-01-01

    Kelly Johnson introduces a series of lessons that incorporate literacy, observation, botany, history, place studies, writing, and art, with a long-term eco-literacy goal of connectedness and a conservation ethic. Johnson's initial idea to use Beatrix Potter as a model in the Lower Elementary classroom came after extensively researching…

  9. Society News: Monica Grady awarded CBE; Grubb Parsons Lecture 2012; Join the RAS; Astronomy on radio for kids; New Fellows; Peter D Hingley

    NASA Astrophysics Data System (ADS)

    2012-08-01

    RAS Fellow Prof. Monica Grady has been made a Commander of the Most Excellent Order of the British Empire (CBE), in recognition of her services to space science. The RAS sponsors the annual Grubb Parsons Lecture, which this year took place on 6 June at the University of Durham. If you are a professional astronomer, geophysicist, or similar, a student studying these disciplines, or simply someone with a serious interest in them, we urge you to apply for membership of the RAS. Outreach is an important activity for the RAS. We recently supported an astronomy series called Deep Space High on the digital radio channel Fun Kids.

  10. Distribution of guppies Poecilia reticulata (Peters, 1860) and Phalloceros caudimaculatus (Hensel, 1868) along a polluted stretch of the Paraíba do Sul River, Brazil.

    PubMed

    Araújo, F G; Peixoto, M G; Pinto, B C T; Teixeira, T P

    2009-02-01

    Cyprinodontiformes fishes (guppies) are widely distributed in Neotropical regions and use deteriorated microhabitats in rivers where few species can occur. This study was carried out in a stretch of the Paraíba do Sul River in bracketing a large urban-industrial complex. The aim was to assess eventual effects that the industrial complex could have on distribution of two closely related fish species of guppies, Phalloceros caudimaculatus and Poecilia reticulata. The area was divided into three zones: Z1, 40 km upriver of the major urban-industrial complex of Volta Redonda; Z2, just down river of the complex; and Z3, 30 km down river of the complex. Six sites (two in each zone) were sampled monthly between November 1998 and October 1999, using a standardized fishing effort with cast net throws, trays lifts and seine hauls, covering different microhabitats, that is, riffles, pools and the proximity of the river's margins. Poecilia reticulata was widely distributed, peaking at Z2, the most polluted area, while P. caudimaculatus showed the highest abundance at Z3, being almost absent in Z1. Both species occurred in high numbers throughout the year but they were scarce between April and June. Females outnumbered males for both species in most size classes and at all sites. Juveniles were more abundant than adults, with non-pregnant females outnumbering pregnant ones. Condition factor was always higher in males than females but only males P. reticulata showed significant difference among the three zones, with the highest values at Z2. The higher number of females confirms the expectation that these species can use very polluted areas and that availability of food provided by organic loads allowed their distribution all over the area. Although these two species have shown indication of spatial separation in the study area, their similar seasonal patterns of occurrence suggest that they respond in a similar way to changes in environmental conditions. PMID:19347144

  11. A Plea for Scientific Ambitions: Reply to Commentaries from Martin Wieser, Nikolai Veresov, Asger Neumann, and Peter Krøjgaard.

    PubMed

    Mammen, Jens

    2016-09-01

    The paper is a reply to commentaries to "Activity theories and the Ontology of Psychology: Learning from Danish and Russian Experiences" (Mammen and Mironenko 2015). At the same time it is an attempt to reply to more general issues raised by the commentators and an attempt to further develop some general ideas from our paper with a focus on the introduction of the new analytical concepts sense and choice categories. These concepts have been elaborated in an axiomatic frame in (Mammen 2016) and the present paper is thus also pointing forwards to that and supporting it with examples from research on adult human relations of love and affection and on infant cognitive development. A few examples from myth and literature are referred to also. The ambition is to introduce new analytical tools across schools and domains of psychology which open for theoretical inclusion of new phenomena and re-structuring of well-known ones. The hope is to surmount some problems, as e.g. the dilemma between dualism and reductionism, which have been obstacles in the search for conceptual and methodological coherence in psychology. In the first place the hope is also to sharpen the analytical, critical and practical potential of psychology as a science. The ambition is not, here and now, to develop a comprehensive general theory as a container for the huge amount of empirical results collected using very heterogeneous criteria for what belongs to the domain of psychology and very heterogeneous conceptual frames. Here we still need some patience following the lesson from natural science, step by step including new domains as the conceptual and practical frames are expanding, but on the other hand not excluding anything apriori. PMID:27251641

  12. Simulation of ground-water flow in the St Peter aquifer in an area contaminated by coal-tar derivatives, St Louis Park, Minnesota

    USGS Publications Warehouse

    Lorenz, D.L.; Stark, J.R.

    1990-01-01

    Model simulations also indicated that drawdown caused by pumping two wells, each pumping at 75 gallons per minute and located about 1 mile southeast of the source of contamination, would be effective in controlling movement and volume of contaminated ground water in the immediate area of the source of contamination. Some contamination may already have moved beyond the influence of these wells, however, because of a complex set of hydraulic conditions.

  13. Medicus Petrus Hispanus (c1205-77 Peter of Spain): a XIII century Pope and Author of a Medieval Sex Guide.

    PubMed

    Ambrose, Charles T

    2013-05-01

    Petrus Hispanus was the only practicing physician ever to become Pope (1276-77). By all accounts he was an interim choice when rival French and Italian Cardinals could not elect one of their own nationality. Although not clearly responsible for any major political actions by the Church, Petrus was famous for several centuries after his death because of his secular writings - a text on logic (Summulae logicales) and a handbook on medicine (Thesaurus pauperum). The latter is noteworthy because it contains two sections on coitus - how to enhance the sexual act and how to subdue sexual urges. Promoting coitus seems an odd topic for a medieval Catholic cleric-writer and raises the question as to whether the first section may have been added by a later copyist or editor, but an examination of a very early manuscript of the Thesaurus gives assurance that the two sexual sections were written by Petrus, probably around 1270. PMID:24585747

  14. Methanol extract of Nyctanthes arbortristis seeds enhances non-specific immune responses and protects Oreochromis mossambicus (Peters) against Aeromonas hydrophila infection.

    PubMed

    Kirubakaran, C John Wesly; Subramani, Parasuraman Aiya; Michael, R Dinakaran

    2016-04-01

    Immunostimulation using medicinal plant extracts is a promising approach for prevention and control of diseases with reference to sustainable fish farming. Oreochromis mossambicus, dubbed as aquatic chicken is a cultured fish worldwide and a laboratory model organism. Aeromonas hydrophila is one of the major bacterial pathogens in fish farming that causes huge loss to aquaculture industries. In this study, we investigated the efficacy of methanol extract of Nyctanthes arbortristis seeds on disease resistance of O. mossambicus against live virulent A. hydrophila. We also investigated its effect on the non-specific immune parameters such as serum lysozyme, myeloperoxidase, antiprotease and specific immune parameters in terms of specific serum antibody titres assayed by bacterial agglutination test. Our studies indicate that intra-peritoneal administration of 20mg/kg methanol extract increases the Relative Percent Survival (RPS) of O. mossambicus challenged with LD80 of A. hydrophila. Further, both non-specific and specific immune parameters were enhanced by the methanol extract. Further experiments at molecular levels in the laboratory and also efficacy testing at field level are essential before applying this plant product in aquaculture industry. PMID:27033940

  15. Seasonal dynamics of the density of the crab larvae (Decapoda: Brachyura et Anomura) in Minonosok Bay of Pos'eta Bay (Peter the Great Bay, Sea of Japan)

    NASA Astrophysics Data System (ADS)

    Grigoryeva, N. I.

    2013-03-01

    As the materials for this project, we used data on the distribution of the larvae of the Asian paddle crab Charybdis japonicus (A. Milne-Edwards, 1861); the spider crabs Hyas coarctatus ursinus (= Hyas ursinus) (Rathbun, 1924), Pugettia quadridens (de Haan, 1839), and Pisoides bidentatus (H. Milne-Edwards, 1873); the samurai crab Paradorippe granulata (= Dorippe granulata) (de Haan, 1841); the pea crab Pinnixa rathbuni (Sakai, 1934); and the porcelain crab Pachycheles stevensii (Stimpson, 1858) in Minonosok Bay of Pos'eta Bay obtained during 2000-2002 and in 2004. The planktonic samples were collected from the last third of May to September. The greatest density of the larvae was observed in May, mid-June, late June-early July, and late July-early August. The greatest densities of the crab larvae and the decapod larvae ranged from 20.4 to 48.2 and from 88.4 to 245.3 specimens/m3. The schedule of the crab larvae's occurrence in the plankton is provided for the first time. The distribution of the density showed pronounced patchiness.

  16. Effects of cadmium, naphthalene, and DDVP on gut carbohydrases activity in bream (Abramis brama L. ) and Mozambique tilapia (Oreochromis mossambicus Peters)

    SciTech Connect

    Golovanova, I.L.; Chuiko, G.M.; Pavlov, D.F. )

    1994-03-01

    Previous research has shown that sublethal concentrations of cadmium, naphthalene and dichlorvos (DDVP) decreased growth rates in bream and Mozambique tilapia. One of the factors known to affect fish growth is the activity of gut digestive enzymes such as of lipases, proteases, carbohydrases. We assumed that toxicant-induced inhibition of the digestive enzyme activity and, consequently, the impaired digestion of food may contribute to the reduction of growth in fish exposed to toxicants. However, the influence of toxicants on digestive enzyme activities is poorly studied. The contribution of toxicant-induced changes of digestive enzymes activity to growth rate retardation in exposed fish remains unknown. The goal of this study was to examine the influence of an organophosphorus insecticide DDVP, a polyaromatic hydrocarbon naphthalene, and a metal cadmium on fish gut carbohydrase (CH) activity. 14 refs., 2 tabs.

  17. From Landau`s hydrodynamical model to field theory model to field theory models of multiparticle production: a tribute to Peter...

    SciTech Connect

    Cooper, F.

    1996-12-31

    We review the assumptions and domain of applicability of Landau`s Hydrodynamical Model. By considering two models of particle production, pair production from strong electric fields and particle production in the linear {sigma} model, we demonstrate that many of Landau`s ideas are verified in explicit field theory calculations.

  18. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Eastern Paralyzed Veterans Association, Inc., James J. Peters, Terrance Moakley, and Denise Figueroa... between Eastern Paralyzed Veterans Association of Pennsylvania, Inc., and James J. Peters,...

  19. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Eastern Paralyzed Veterans Association, Inc., James J. Peters, Terrance Moakley, and Denise Figueroa... between Eastern Paralyzed Veterans Association of Pennsylvania, Inc., and James J. Peters,...

  20. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Eastern Paralyzed Veterans Association, Inc., James J. Peters, Terrance Moakley, and Denise Figueroa... between Eastern Paralyzed Veterans Association of Pennsylvania, Inc., and James J. Peters,...

  1. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Eastern Paralyzed Veterans Association, Inc., James J. Peters, Terrance Moakley, and Denise Figueroa... between Eastern Paralyzed Veterans Association of Pennsylvania, Inc., and James J. Peters,...

  2. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Eastern Paralyzed Veterans Association, Inc., James J. Peters, Terrance Moakley, and Denise Figueroa... between Eastern Paralyzed Veterans Association of Pennsylvania, Inc., and James J. Peters,...

  3. Some Historical Points of Interest in Göttingen

    NASA Astrophysics Data System (ADS)

    Hentschel, Klaus

    The Georgia Augusta University of Göttingen, founded in 1737, was a child of the Enlightenment, and the new sciences have always played a major role here.1 Among the teachers of physics, physical chemistry, astronomy, and related subjects we find Johann Christian Polykarp Erxleben, Georg Christoph Lichtenberg, Johann Tobias Mayer, Carl Friedrich Gauss, Johann B. Listing, Wilhelm Eduard Weber, Woldemar Voigt, Friedrich Kohlrausch, Eduard Riecke, Walther Nernst and Peter Debye — the last two subsequently moved on to Berlin. In the 1920s, physics students were jestingly referred to as “Frankierte, Bornierte und Polierte” (loosely translated as stamped, limited and polished), in allusion to their teachers, the theoretical physicist Max Born and the experimentalists James Franck and Robert Wichard Pohl, the first two being important figures in the history of quantum theory, the third, one of the founding fathers of experimental solid state physics.2 The National Socialist’s rise to power had a devastating effect on this world-renowned center for physics and mathematics. Most of its high-caliber scientists either were dismissed on the basis of the racist “Law for the Restoration of the Professional Civil Service” or themselves felt compelled to emigrate: About a dozen members of the physics faculty, including Born and Franck, and ten from the mathematics faculty left Göttingen.3 After the war, Richard Becker, who in 1936 had received a compulsory order to take the chair for theoretical physics vacant since Born’s emigration, and Friedrich Hund, who was also an enthusiastic historian of science, distinguished themselves as physics teachers there but the university as a whole never recovered its international standing of before 1933 (see Figs. 1 and 2).

  4. Weakness

    MedlinePlus

    ... spine) Stroke MUSCLE DISEASES Becker muscular dystrophy Dermatomyositis Muscular dystrophy (Duchenne) Myotonic dystrophy POISONING Botulism Poisoning ( insecticides , nerve gas) Shellfish poisoning OTHER Anemia Myasthenia gravis Polio

  5. Using Numbers in Qualitative Research

    ERIC Educational Resources Information Center

    Maxwell, Joseph A.

    2010-01-01

    The use of numerical/quantitative data in qualitative research studies and reports has been controversial. Prominent qualitative researchers such as Howard Becker and Martyn Hammersley have supported the inclusion of what Becker called "quasi-statistics": simple counts of things to make statements such as "some," "usually," and "most" more…

  6. Natalist Policies in the United States

    ERIC Educational Resources Information Center

    Lopoo, Leonard M.; Raissian, Kerri M.

    2012-01-01

    This retrospective reviews the policies that affect the fertility of American women, both policies designed to alter fertility intentionally as well as those that change childbearing unintentionally. Becker's seminal work on the economics of fertility serves as the theoretical foundation for this literature. After describing Becker's economic…

  7. Definitions and Omissions of Heroism

    ERIC Educational Resources Information Center

    Martens, Jeffrey W.

    2005-01-01

    This article presents comments on "The Heroism of Women and Men" by Selwyn W. Becker and Alice H. Eagly. Their article specifically addressed the "cultural association of heroism with men and masculinity . . . in natural settings." Becker and Eagly evidenced roughly equivalent rates of heroism by women and men in a variety of settings. However,…

  8. High School Students' Use of Paper-Based and Internet-Based Information Sources in the Engineering Design Process

    ERIC Educational Resources Information Center

    Pieper, Jon; Mentzer, Nathan

    2013-01-01

    Mentzer and Becker (2011) and Becker and Mentzer (2012) demonstrated that high school students engaged in engineering design problems spent more time accessing information and spent more time designing when provided with Internet access. They studied high school students engaged in an engineering design challenge. The two studies attempted to…

  9. Comparing the Heroism of Women and Men

    ERIC Educational Resources Information Center

    Eagly, Alice H.; Becker, Selwyn W.

    2005-01-01

    This article presents comments on "Definitions and Omissions of Heroism" by Jeffery W. Martens which is a comment on the original article "The Heroism of Women and Men" by Selwyn W. Becker and Alice H. Eagly. Becker and Eagly welcome the opportunity to discuss the questions about defining heroism that Martens raised in his comment on their…

  10. A Survey of Principles Instructors: Why Lecture Prevails

    ERIC Educational Resources Information Center

    Goffe, William L.; Kauper, David

    2014-01-01

    For many years, surveys have shown that lecture is the dominant method for teaching principles of economics (Watts and Schaur 2011; Watts and Becker 2008; Becker and Watts 1996, 2001a, b). The authors confirm this and augment it by asking why principles instructors teach the way they do. The respondents, 340 principles instructors at the 2012…

  11. Travel to Learn: How, When, and Why to Apply for Overseas Professional Development

    ERIC Educational Resources Information Center

    Cook, Erika; Becker, Aaron

    2013-01-01

    In this article, Erika Cook and Aaron Becker suggest teachers travel to "unfamiliar" lands to not only breathe life into global lessons but also to gain new perspectives and experiences as educators. For teachers who dread teaching about an unfamiliar place or culture, Cook and Becker recommend considering the very real opportunities to…

  12. A possible pathophysiological role of tyrosine hydroxylase in Parkinson's disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer.

    PubMed

    Nakashima, Akira; Ota, Akira; Kaneko, Yoko S; Mori, Keiji; Nagasaki, Hiroshi; Nagatsu, Toshiharu

    2013-01-01

    Postmortem brain biochemistry has revealed that the main symptom of movement disorder in Parkinson's disease (PD) is caused by a deficiency in dopamine (DA) at the nerve terminals of degenerating nigro-striatal DA neurons in the striatum. Since tyrosine hydroxylase (TH) is the rate-limiting enzyme for the biosynthesis of DA, TH may play an important role in the disease process of PD. DA regulated by TH activity is thought to interact with α-synuclein protein, which results in intracellular aggregates called Lewy bodies and causes apoptotic cell death during the aging process. Human TH has several isoforms produced by alternative mRNA splicing, which may affect activation by phosphorylation of serine residues in the N-terminus of TH. The activity and protein level of TH are decreased to cause DA deficiency in the striatum in PD. However, the homo-specific activity (activity/enzyme protein) of TH is increased. This increase in TH homo-specific activity suggests activation by increased phosphorylation at the N-terminus of the TH protein for a compensatory increase in DA synthesis. We recently found that phosphorylation of the N-terminal portion of TH triggers proteasomal degradation of the enzyme to increase TH turnover. We propose a hypothesis that this compensatory activation of TH by phosphorylation in the remaining DA neurons may contribute to a further decrease in TH protein and activity in DA neurons in PD, causing a vicious circle of decreasing TH activity, protein level and DA contents. Furthermore, increased TH homo-specific activity leading to an increase in DA may cause toxic reactive oxygen species in the neurons to promote neurodegeneration. PMID:22644539

  13. Leadership, Management & Team Working in Nursing (2 nd Edition) Ellis Peter and Bach Shirley Leadership, Management & Team Working in Nursing (2 nd Edition) 192pp £19.99 Learning Matters/SAGE 9781473918849 1473918847 [Formula: see text].

    PubMed

    2016-04-01

    This book is part of the Transforming Nursing Practice series and is written with student nurses in mind. It is clearly linked to the Nursing and Midwifery Council Standards for pre-registration nursing education. PMID:27050002

  14. Resource Sharing: New Technologies as a Must for Universal Availability of Information. International Essen Symposium (16th, Essen, Germany, October 18-21, 1993). Festschrift in Honor of Hans-Peter Geh.

    ERIC Educational Resources Information Center

    Helal, Ahmed H., Ed.; Weiss, Joachim W.

    This proceedings includes the following papers presented at the 16th International Essen Symposium: "Electronic Resource Sharing: It May Seem Obvious, But It's Not as Simple as it Looks" (Herbert S. White); "Resource Sharing through OCLC: A Comprehensive Approach" (Janet Mitchell); "The Business Information Network: Improving European Enterprise…

  15. Into the Curriculum. Reading/Language Arts: Peter Rabbit Pop-Up; Science and Social Studies: Telephones through Time; Social Studies/Mathematics: An Imaginary Investment; Social Studies: Libraries Reflect Our Culture; Social Studies: Seward's Folly and Alaska.

    ERIC Educational Resources Information Center

    Salter, Virtys

    2002-01-01

    Provides five fully developed library media activities that are designed for use with specific curriculum units in reading, language arts, science, social studies, and mathematics. Library media skills, curriculum objectives, grade levels, resources, instructional roles, procedures, evaluation, and follow-up are describes for each activity. (LRW)

  16. "All the men here have the Peter Pan syndrome--they don't want to grow up": Navajo adolescent mothers' intimate partner relationships--a 15-year perspective.

    PubMed

    Dalla, Rochelle L; Marchetti, Alexandria M; Sechrest, Elizabeth Beth A; White, Jennifer L

    2010-07-01

    In 1992 and 1995, data were collected from 29 Navajo Native American adolescent mothers. In 2007 and 2008, data were collected from 21 of the original 29 (72%). Guided by feminist family theory, this investigation sought to (a) examine Navajo adolescent mothers' intimate partner relationships during the transition to parenthood, (b) identify themes in the young mothers' intimate partnerships across time, and (c) assess participants' psychosocial well-being in adulthood. Four themes emerged in the women's long-term intimate relationships: limited support, substance abuse, infidelity, and intimate partner violence. Implications of the findings and suggestions for future research are discussed. PMID:20558768

  17. Applying n-dimensional hypervolumes for species delimitation: unexpected molecular, morphological, and ecological diversity in the Leaf-Toed Gecko Phyllodactylus reissii Peters, 1862 (Squamata: Phyllodactylidae) from northern Peru.

    PubMed

    Koch, Claudia; Flecks, Morris; Venegas, Pablo J; Bialke, Patrick; Valverde, Sebastian; Rödder, Dennis

    2016-01-01

    An integrative taxonomic approach based on morphology, molecular analyses, and climatic niche modeling was used to uncover cryptic diversity in the phyllodactylid gecko species Phyllodactylus reissii. At least three distinct species could be identified among the examined specimens from southern Ecuador and northern Peru. Phyllodactylus magister, described by Noble (1924) from arid Andean valleys of the Chinchipe and Marañón rivers in the Peruvian Department of Cajamarca and synonymized with P. reissii by Dixon & Huey (1970) is elevated from synonymy and a detailed redescription is provided. A new species of the genus Phyllodactylus from the Andean dry forest of the southern Marañón valley is identified and described herein. Phyllodactylus pachamama sp. nov. is differentiated from other South American congeners on the basis of mtDNA sequence divergence, morphological characters, and differences in the realized climatic niche. At least in Peru, P. reissii seems to primarily inhabit the northern coastal region west of the Andes, while the inter-Andean area along the Río Marañón and its tributaries seems to be inhabited mostly by other species of the genus, which are endemic to this area. The Andean valleys are underestimated in terms of biodiversity and lack thorough investigation and conservation actions. PMID:27615910

  18. We Blame the Parents! a Response to "Cultural Capital as an Explanation of Variation in Participation in Higher Education" by John Noble and Peter Davies ("British Journal of Sociology of Education 30, No. 5")

    ERIC Educational Resources Information Center

    Harrison, Neil; Waller, Richard

    2010-01-01

    This paper offers a response to a recent article where the authors argue cultural capital is the only determinant of the propensity of young people to seek to enter higher education, dismissing other indicators such as social class. This response questions the support the original authors draw from other literature and offers criticism of the…

  19. Conquer Chronic Pain: An Innovative Mind-Body Approach Przekop Peter Conquer Chronic Pain: An Innovative Mind-Body Approach 200pp £13.50 Hazelden Publishing 9781616497897 1616497890 [Formula: see text].

    PubMed

    2016-01-27

    The focus of this book is on helping people to live effectively with chronic pain by addressing how the mind interprets pain and how a negative social, emotional or physical context to the pain can act as a barrier to recovery. PMID:26967872

  20. Three new cecidogenous species of Palaeomystella Fletcher (Lepidoptera, Momphidae) from the Brazilian Atlantic Rain Forest.

    PubMed

    Luz, Fernando A; Gonçalves, Gislene L; Moreira, Gilson R P; Becker, Vitor O

    2014-01-01

    Three new cecidogenous species of Palaeomystella Fletcher (Lepidoptera, Momphidae) from the Brazilian Atlantic Rain Forest are described. Larvae of P. fernandesi Moreira & Becker, sp. n., P. rosaemariae Moreira & Becker, sp. n. and P. tavaresi Becker & Moreira, sp. n. induce galls, respectively, on Tibouchina sellowiana (Cham.) Cogn., T. asperior (Cham.) Cogn. and T. fissinervia (Schrank & Mart. ex DC.) Cogn. (Melastomataceae). Adults, immature stages and galls are illustrated, and data on life history and a preliminary analysis of mitochondrial DNA sequences, including related species, are also provided. PMID:25152676

  1. Three new cecidogenous species of Palaeomystella Fletcher (Lepidoptera, Momphidae) from the Brazilian Atlantic Rain Forest

    PubMed Central

    Luz, Fernando A.; Gonçalves, Gislene L.; Moreira, Gilson R. P.; Becker, Vitor O.

    2014-01-01

    Abstract Three new cecidogenous species of Palaeomystella Fletcher (Lepidoptera, Momphidae) from the Brazilian Atlantic Rain Forest are described. Larvae of P. fernandesi Moreira & Becker, sp. n., P. rosaemariae Moreira & Becker, sp. n. and P. tavaresi Becker & Moreira, sp. n. induce galls, respectively, on Tibouchina sellowiana (Cham.) Cogn., T. asperior (Cham.) Cogn. and T. fissinervia (Schrank & Mart. ex DC.) Cogn. (Melastomataceae). Adults, immature stages and galls are illustrated, and data on life history and a preliminary analysis of mitochondrial DNA sequences, including related species, are also provided. PMID:25152676

  2. Highlights of Astronomy

    NASA Astrophysics Data System (ADS)

    van der Hucht, Karel

    2008-02-01

    Preface Karel A. van der Hucht; Part I. Invited Discourses: Part II. Joint Discussions: 1. Particle acceleration - from Solar System to AGN Marian Karlicky and John C. Brown; 2. Pulsar emission and related phenomena Werner Becker, Janusz A. Gil and Bronislaw Rudak; 3. Solar activity regions and magnetic structure Debi Prasad Choudhary and Michal Sobotka; 4. The ultraviolet universe: Stars from birth to death Ana I. Gomez de Castro and Martin A. Barstow; 5. Calibrating the top of the stellar M-L relationship Claus Leitherer, Anthony F. J. Moat and Joachim Puls; 6. Neutron stars and black holes in star clusters Frederic A. Rasio; 7. The Universe at z > 6 Daniel Schaerer and Andrea Ferrara; 8. Solar and stellar activity cycles Klaus G. Strassmeier and Alexander Kosovichev; 9. Supernovae: One millennium after SN 1006 P. Frank Winkler, Wolfgang Hillebrandt and Brian P. Schmidt; 10. Progress in planetary exploration missions Guy J. Consolmagno; 11. Pre-solar grains as astrophysical tools Anja C. Andersen and John C. Lattanzio; 12. Long wavelength astrophysics T. Joseph W. Lazio and Namir E. Kassim; 13. Exploiting large surveys for galactic astronomy Christopher J. Corbally, Coryn A. L. Bailer-Jones, Sunetra Giridhar and Thomas H. Lloyd Evans; 14. Modeling dense stellar systems Alison I. Sills, Ladislav Subr and Simon F. Portegies Zwart; 15. New cosmology results from the Spitzer Space Telescope George Helou and David T. Frayer; 16. Nomenclature, precession and new models in fundamental astronomy Nicole Capitaine, Jan Vondrak & James L. Hilton; 17. Highlights of recent progress in seismology of the Sun and Sun-like stars John W. Leibacher and Michael J. Thompson; Part III. Special Sessions: SpS 1. Large astronomical facilities of the next decade Gerard F. Gilmore and Richard T. Schilizzi; SpS 2. Innovation in teaching and learning astronomy methods Rosa M. Ros and Jay M. Pasachoff; SpS 3. The Virtual Observatory in action: New science, new technology and next

  3. Highlights of Astronomy, Volume 14

    NASA Astrophysics Data System (ADS)

    van der Hucht, Karel

    2007-08-01

    Preface Karel A. van der Hucht; Part I. Invited Discourses: Part II. Joint Discussions: 1. Particle acceleration - from Solar System to AGN Marian Karlicky and John C. Brown; 2. Pulsar emission and related phenomena Werner Becker, Janusz A. Gil and Bronislaw Rudak; 3. Solar activity regions and magnetic structure Debi Prasad Choudhary and Michal Sobotka; 4. The ultraviolet universe: Stars from birth to death Ana I. Gomez de Castro and Martin A. Barstow; 5. Calibrating the top of the stellar M-L relationship Claus Leitherer, Anthony F. J. Moat and Joachim Puls; 6. Neutron stars and black holes in star clusters Frederic A. Rasio; 7. The Universe at z > 6 Daniel Schaerer and Andrea Ferrara; 8. Solar and stellar activity cycles Klaus G. Strassmeier and Alexander Kosovichev; 9. Supernovae: One millennium after SN 1006 P. Frank Winkler, Wolfgang Hillebrandt and Brian P. Schmidt; 10. Progress in planetary exploration missions Guy J. Consolmagno; 11. Pre-solar grains as astrophysical tools Anja C. Andersen and John C. Lattanzio; 12. Long wavelength astrophysics T. Joseph W. Lazio and Namir E. Kassim; 13. Exploiting large surveys for galactic astronomy Christopher J. Corbally, Coryn A. L. Bailer-Jones, Sunetra Giridhar and Thomas H. Lloyd Evans; 14. Modeling dense stellar systems Alison I. Sills, Ladislav Subr and Simon F. Portegies Zwart; 15. New cosmology results from the Spitzer Space Telescope George Helou and David T. Frayer; 16. Nomenclature, precession and new models in fundamental astronomy Nicole Capitaine, Jan Vondrak & James L. Hilton; 17. Highlights of recent progress in seismology of the Sun and Sun-like stars John W. Leibacher and Michael J. Thompson; Part III. Special Sessions: SpS 1. Large astronomical facilities of the next decade Gerard F. Gilmore and Richard T. Schilizzi; SpS 2. Innovation in teaching and learning astronomy methods Rosa M. Ros and Jay M. Pasachoff; SpS 3. The Virtual Observatory in action: New science, new technology and next

  4. Genetics Home Reference: Angelman syndrome

    MedlinePlus

    ... Bichell TJ, Lee HS, Sahoo T, Waisbren SE, Bird LM, Peters SU. A neurodevelopmental survey of Angelman ... Peters SU, Sahoo T, Sarco D, Waisbren SE, Bird LM. Angelman syndrome: Mutations influence features in early ...

  5. 78 FR 13384 - Sunshine Act Meetings.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-27

    ...: Candi Bing, (202) 314-6403 or by email at bingc@ntsb.gov . FOR MEDIA INFORMATION CONTACT: Peter Knudson, (202) 314-6100 or by email at peter.knudson@ntsb.gov . Dated: Monday, February 25, 2013. Candi R....

  6. 3. HISTORIC AMERICAN BUILDINGS SURVEY. S. Lucas, Photographer, 1934. ORIGINAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. HISTORIC AMERICAN BUILDINGS SURVEY. S. Lucas, Photographer, 1934. ORIGINAL PERSPECTIVE, SS. PETER & PAUL'S JESUIT CHURCH, DETROIT MICHIGAN - Sts. Peter & Paul's Jesuit Church, East Jefferson Avenue & Saint Antoine Street, Detroit, MI

  7. 42 CFR 406.34 - Determination of months to be counted for premium increase: Reenrollment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... Peter M enrolled during his initial enrollment period, terminated his first coverage period in August... through March, 1980) were not enough to require any increase in the premium. Peter terminated his...

  8. 42 CFR 406.34 - Determination of months to be counted for premium increase: Reenrollment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... Peter M enrolled during his initial enrollment period, terminated his first coverage period in August... through March, 1980) were not enough to require any increase in the premium. Peter terminated his...

  9. Tutorials for Africa - Diarrhea: MedlinePlus

    MedlinePlus

    ... Judith Allsaints Apio Chaudhari Mugdha Ramachandra Richard Lunyata Peter Agaba Elizabeth Nakabuye Team of medical students in ... Valentine Kahababo Art and audio team - Kampala, Uganda Peter Mukiibi Kenneth Nek Daniel Hama Contact the Makerere ...

  10. 1. HISTORIC AMERICAN BUILDINGS SURVEY. S. Lucas, Photographer, 1934 SS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. HISTORIC AMERICAN BUILDINGS SURVEY. S. Lucas, Photographer, 1934 SS. PETER & PAUL'S JESUIT CHURCH, DETROIT MICHIGAN - Sts. Peter & Paul's Jesuit Church, East Jefferson Avenue & Saint Antoine Street, Detroit, MI

  11. 2. HISTORIC AMERICAN BUILDINGS SURVEY. S. Lucas, Photographer, 1934 ENTRANCE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. HISTORIC AMERICAN BUILDINGS SURVEY. S. Lucas, Photographer, 1934 ENTRANCE DETAIL, SS. PETER & PAUL'S JESUIT CHURCH, DETROIT MICHIGAN - Sts. Peter & Paul's Jesuit Church, East Jefferson Avenue & Saint Antoine Street, Detroit, MI

  12. 42 CFR 406.34 - Determination of months to be counted for premium increase: Reenrollment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... Peter M enrolled during his initial enrollment period, terminated his first coverage period in August... through March, 1980) were not enough to require any increase in the premium. Peter terminated his...

  13. Prostate cancer

    MedlinePlus

    ... Wein AJ, Kavoussi LR, Novick AC, Patin AW, Peters CA, eds. Campbell-Walsh Urology . 10th ed. Philadelphia, ... Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA, eds. Campbell-Walsh Urology . 10th ed. Philadelphia, ...

  14. 42 CFR 406.34 - Determination of months to be counted for premium increase: Reenrollment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... Peter M enrolled during his initial enrollment period, terminated his first coverage period in August... through March, 1980) were not enough to require any increase in the premium. Peter terminated his...

  15. Tutorials for Africa - Malaria: MedlinePlus

    MedlinePlus

    ... Judith Allsaints Apio Chaudhari Mugdha Ramachandra Richard Lunyata Peter Agaba Elizabeth Nakabuye Team of medical students in ... Valentine Kahababo Art and audio team - Kampala, Uganda Peter Mukiibi Kenneth Nek Daniel Hama Contact the Makerere ...

  16. 14. AERIAL VIEW OF POOL AND STRUCTURES Photocopy of photocopy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. AERIAL VIEW OF POOL AND STRUCTURES Photocopy of photocopy of 1931 rendering by Alexander, Becker and Schoeppe, architects and engineers - Glen Echo Park, Crystal Swimming Pool, 7300 McArthur Boulevard, Glen Echo, Montgomery County, MD

  17. GREEN CATALYZED OXIDATION OF HYDROCARBONS IN ALTERNATIVE SOLVENT SYSTEMS GENERATED BY PARIS II DECHEMA; GREEN SOLVENTS FOR CATALYSIS - ENVIRONMENTALLY BENIGN REACTION MEDIA

    EPA Science Inventory

    Green catalyzed oxidation of hydrocarbons in alternative solvent systems generated by PARIS II
    Thomas M. Becker, Michael A. Gonzalez, Paul F. Harten; Sustainable Technology Division, Office of Research and Development; United States Environmental Protection Agency, 26 West Mar...

  18. GREEN CATALYZED OXIDATION OF HYDROCARBONS IN ALTERNATIVE SOLVENT SYSTEMS GENERATED BY PARIS II

    EPA Science Inventory

    Green Catalyzed Oxidation of Hydrocarbons in Alternative Solvent Systems Generated by PARIS II

    Michael A. Gonzalez*, Thomas M. Becker, and Paul F. Harten; Sustainable Technology Division, Office of Research and Development; United States Environmental Protection Agency, 26...

  19. LACK OF ANTAGONISM BETWEEN THE BIOCONTROL AGENT GLIOCLADIUM VIRENS AND VESICULAR ARBUSCULAR MYCORRHIZAL FUNGI

    EPA Science Inventory

    Fungal biocontrol agent Gliocladium virens Miller, Giddens & Foster on the colonization of cucumber by the VA mycorrhizal fungi Glomus etunicatum Becker & Gerdemann and Glomus mosseae (Nicol. & Gerd.) Gerdemann & Trappe was investigated. noculum of G. virens grown on wheat bran o...

  20. Nasal polyps

    MedlinePlus

    ... BS, Burks AW, et al, eds. Middleton's Allergy: Principles and Practice . 8th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 43. Becker SS. Surgical management of polyps in the treatment of nasal airway ...

  1. Contracture deformity

    MedlinePlus

    ... following: Brain and nervous system disorders, such as cerebral palsy or stroke Inherited disorders (such as muscular dystrophy ) ... 2011:chap 26. Read More Becker muscular dystrophy Cerebral palsy Duchenne muscular dystrophy Dupuytren contracture Volkmann ischemic contracture ...

  2. A METHODOLOGY FOR THE EVALUATION OF PROCESS SUSTAINABILITY

    EPA Science Inventory

    The twelve principles of green chemistry (Anastas and Warner, 1998) provide a foundation and pathway which allows researchers to incorporate greenness into existing reactions or when developing new technologies. Research from our laboratory (Gonzalez and Becker, 2002) has adopted...

  3. HOMOGENEOUS CATALYSTS FOR THE PARTIAL-OXYGENATION OF SATURATED HYDROCARBONS WITH HYDROGEN PERIOXIDE

    EPA Science Inventory

    A Methodology for the Evaluation of Process Sustainability
    Michael Gonzalez*, Raymond Smith and Thomas Becker

    United States Environmental Protection Agency; Office of Research and Development; Sustainable Technologies Division; 26 West Martin Luther King Drive; Cincinna...

  4. It Bears Repeating: Understanding the Work of the Teacher: Some Light from the Past.

    ERIC Educational Resources Information Center

    Fortgang, Stephen J.

    1980-01-01

    Reviews the work of Howard S. Becker who, in the 1950s, analyzed teaching as a service occupation and drew parallels with other such occupations in terms of worker-client relationships and authority structures. (SJL)

  5. Genetics Home Reference: congenital hyperinsulinism

    MedlinePlus

    ... C, Becker S, Lin YW, Hanna C, Thornton P, Ganguly A, Shyng SL, Stanley CA. Clinical characteristics and ... Hughes N, Ganapathy K, Bhatti T, Stanley CA, Ganguly A. Genotype and phenotype correlations in 417 children ...

  6. 11. TIMBER COLUMN AND CAST IRON COLUMN CAP IN FIFTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. TIMBER COLUMN AND CAST IRON COLUMN CAP IN FIFTH FLOOR WAREHOUSE SPACE. VIEW TO SOUTHWEST. - Commercial & Industrial Buildings, Becker-Hazelton Company Warehouse, 280 Iowa Street, Dubuque, Dubuque County, IA

  7. Muscular Dystrophy: Hope Through Research

    MedlinePlus

    ... programs supported by patient advocacy groups, have attracted biotechnology and pharmaceutical firm investments into therapies for the ... Duchenne to a much milder Becker MD. Two biotechnology companies are currently testing oligonucleotide drugs in advanced ...

  8. Rumination disorder

    MedlinePlus

    ... Katzman DK, Kearney SA, Becker AE. Feeding and eating disorders. In: Feldman M, Friedman LS, Brandt LJ, eds. ... A.M. Editorial team. Related MedlinePlus Health Topics Eating Disorders Browse the Encyclopedia A.D.A.M., Inc. ...

  9. School Boards and the Process of Native American Influence on the Education of Native American Children.

    ERIC Educational Resources Information Center

    Lutz, Frank W.; Barlow, Donald A.

    1981-01-01

    Using Becker's sacred/secular community type continuum and Bailey's concepts of elite/arena council behavior, examined the educational decision making process on the Coeur d'Alene Indian reservation in Idaho. Discusses implications for American Indian education. (GC)

  10. 78 FR 9107 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-07

    ... published on April 11, 2000 (65 FR 19477). Issued in Washington, DC, on February 4, 2013. Robert C. Lauby... following locations: Isugen, NE; Becker, MN; Breckenridge, MN; Dilworth, MN; Harrington, TX; and Holcomb,...

  11. Evaluation of Limb-Girdle Muscular Dystrophy

    ClinicalTrials.gov

    2014-03-06

    Becker Muscular Dystrophy; Limb-Girdle Muscular Dystrophy, Type 2A (Calpain-3 Deficiency); Limb-Girdle Muscular Dystrophy, Type 2B (Miyoshi Myopathy, Dysferlin Deficiency); Limb-Girdle Muscular Dystrophy, Type 2I (FKRP-deficiency)

  12. Margaret Huggins and Tulse Hill Observatory

    NASA Astrophysics Data System (ADS)

    Becker, Barbara J.

    2016-04-01

    Photography, instrument design, methodology, interpretation - all skills brought to William Huggins' observatory by his persistent and careful wife Margaret. Together they developed spectroscopy into a powerful research tool. Barbara Becker tells the story.

  13. HOMOGENEOUS CATALYTIC OXIDATION OF HYDROCARBONS IN ALTERNATIVE SOLVENTS

    EPA Science Inventory

    Homogeneous Catalytic Oxidations of Hydrocarbons in Alternative Solvent Systems

    Michael A. Gonzalez* and Thomas M. Becker, Sustainable Technology Division, Office of Research and Development; United States Environmental Protection Agency, 26 West Martin Luther King Drive, ...

  14. FOREWORD: International determination of the Avogadro constant International determination of the Avogadro constant

    NASA Astrophysics Data System (ADS)

    Massa, Enrico; Nicolaus, Arnold

    2011-04-01

    daily work. Special thanks are addressed to Peter Becker, to whom this issue is dedicated on the occasion of his retirement from work at the Physikalisch-Technische Bundesanstalt. In 1974, young Peter joined the PTB's Avogadro group which, under the direction of Peter Seyfried, followed Bonse's work and improved the measurements of the lattice parameter and the Avogadro constant [5, 6]. In 2004, Peter proposed and backed this project by taking on his shoulders the risks, the management burden and the coordination of the many relevant activities. References [1] Egidi C 1963 Phantasies on a natural unity of mass Nature 200 61-2 [2] Bonse U and Hart M 1965 An x-ray interferometer Appl. Phys. Lett. 6 155-6 [3] Deslattes R D et al 1974 Determination of the Avogadro constant Phys. Rev. Lett. 33 463-6 [4] Zosi G 1983 A neo-Pythagorean approach towards an atomic mass standard Lett. Nuovo Cimento 38 577-80 [5] Becker P et al 1981 Absolute measurement of the (220) lattice plane spacing in a silicon crystal Phys. Rev. Lett. 46 1540-3 [6] Seyfried P et al 1992 A determination of the Avogadro constant Z. Phys. B 87 289-98

  15. 20 CFR 416.1166 - How we deem income to you and your eligible child from your ineligible spouse.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    .... Example 1. Mary, a blind individual, lives with her husband, John, and their disabled child, Peter. Mary and Peter have no income, but John is employed and earns $605 per month. We determine Mary's... is eligible; therefore, there is no income to be deemed to Peter. Example 2. Al, a...

  16. 20 CFR 416.1166 - How we deem income to you and your eligible child from your ineligible spouse.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    .... Example 1. Mary, a blind individual, lives with her husband, John, and their disabled child, Peter. Mary and Peter have no income, but John is employed and earns $605 per month. We determine Mary's... is eligible; therefore, there is no income to be deemed to Peter. Example 2. Al, a...

  17. 20 CFR 416.1166 - How we deem income to you and your eligible child from your ineligible spouse.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    .... Example 1. Mary, a blind individual, lives with her husband, John, and their disabled child, Peter. Mary and Peter have no income, but John is employed and earns $605 per month. We determine Mary's... is eligible; therefore, there is no income to be deemed to Peter. Example 2. Al, a...

  18. 20 CFR 416.1166 - How we deem income to you and your eligible child from your ineligible spouse.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    .... Example 1. Mary, a blind individual, lives with her husband, John, and their disabled child, Peter. Mary and Peter have no income, but John is employed and earns $605 per month. We determine Mary's... is eligible; therefore, there is no income to be deemed to Peter. Example 2. Al, a...

  19. 20 CFR 416.1166 - How we deem income to you and your eligible child from your ineligible spouse.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    .... Example 1. Mary, a blind individual, lives with her husband, John, and their disabled child, Peter. Mary and Peter have no income, but John is employed and earns $605 per month. We determine Mary's... is eligible; therefore, there is no income to be deemed to Peter. Example 2. Al, a...

  20. What You See Is Not What You Get

    ERIC Educational Resources Information Center

    White-McMahon, Meredith

    2010-01-01

    When upset, 15-year-old Peter overreacts, dumping verbal hostility on everyone, even those trying to help. Peter's attempt to see the principal--who was out of the office--led to an emotionally explosive crisis. In this life space crisis intervention (LSCI), staff calmly tried to help Peter clarify distorted reality. But patient questioning raised…

  1. Recognizing and Nurturing Hidden Creative Potential

    ERIC Educational Resources Information Center

    Connell, Elizabeth E.

    2010-01-01

    Peter, 7 years old, spends most of his time playing with his stick alone. After several unsuccessful attempts to get Peter to join his cousins, his aunt asks the boy's parents if they have considered having him evaluated by a psychologist. Peter's parents are not as concerned about the stick behavior as is his aunt. Although the attachment to his…

  2. Shaking Off Inertia.

    ERIC Educational Resources Information Center

    Campbell, David N.

    1991-01-01

    According to Tom Peters's book "Thriving on Chaos," change must become the norm, not cause for alarm. What Peters saw in the business world predominates in schools--the same inertia, fear of innovation, and rejection of technology. Schools can profit by taking Peters's advice about using research and changing antiquated teaching practices. (MLH)

  3. LSWAVE 2000: Lasers and short-wavelength applications

    NASA Astrophysics Data System (ADS)

    Sandner, W.

    2001-07-01

    LSWAVE 2000 was organized as a Satellite Workshop to the Seventh International Conference on Synchrotron Radiation Instrumentation SRI 2000. It was held on Saturday, August 26, 2000, at the Technische Universität Berlin, and was jointly organized by the Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy (MBI) and the Technical University Berlin (TUB). The organizing committee consisted of Wilhelm Raith (chairman), Wolfgang Sandner, Ingolf Hertel, Manfred Wick, Bernd Winter, Tatjana Gießel, Holger Stiel, Ingo Will, Ursula Bayr (secretary) and Silvia Szlapka (secretary). Continuing information on the Workshop and its proceedings may be found under http://www.mbi-berlin.de/lswave2000/.

  4. Promising new diesel conversion package arrives here from Denmark

    SciTech Connect

    Not Available

    1992-12-01

    This paper reports that San Diego-based officials representing a Danish manufacturer are joining here with a major Southern California transit company to unveil the first two buses in the U.S. that have been switched from diesel to propane, utilizing a newly-introduced and widely acclaimed conversion package. The product is the result of nearly three years of research and development by several Danish inventors including Holger Storm Anderson, who now serves as president of Alex Jensen A/S (Skibby, Denmark), the operator of the buses.

  5. Surface nanobubbles and micropancakes

    NASA Astrophysics Data System (ADS)

    Seddon, James R. T.

    2013-05-01

    , Ziaul Haque Ansari and Jianguo Mi The effect of PeakForce tapping mode AFM imaging on the apparent shape of surface nanobubblesWiktoria Walczyk, Peter M Schön and Holger Schönherr Coarse-grained modelling of surface nanobubblesPatrick Grosfils Understanding the stability of surface nanobubblesShuo Wang, Minghuan Liu and Yaming Dong Hydrogen nanobubble at normal hydrogen electrodeS Nakabayashi, R Shinozaki, Y Senda and H Y Yoshikawa Particle tracking around surface nanobubblesErik Dietrich, Harold J W Zandvliet, Detlef Lohse and James R T Seddon Imaging surface nanobubbles at graphite--water interfaces with different atomic force microscopy modesChih-Wen Yang, Yi-Hsien Lu and Ing-Shouh Hwang

  6. Challenges During Baha Surgery: Our Experience.

    PubMed

    Marfatia, Hetal; Priya, Ratna; Sathe, Nilam U; Mishra, Shampa

    2016-09-01

    Baha has proven performance and advantages for patients with aural atresia or chronic ear drainage. Being a per cutaneous osseo integrated implant the skin around the fixture is in contact with a foreign body that leads to chronic inflammatory reaction and complications such as skin irritation and overgrowth occur frequently. Challenges that are faced during Baha surgery include those during candidate selection, work up, anesthesia related as well as intra-operative and post operative complications. Ours was a retrospective and observational study where case records of 10 patients who underwent Baha surgery in the Department of E.N.T during the time period from January 2010 to June 2013 were reviewed. Here, the candidates were advised Baha either for congenital external ear deformity or single sided deafness. Out of 10 patients, who underwent Baha implantation, 8 underwent single staged Baha implant and two patients had two staged implant owing to bone thickness <3 mm behind temporo-parietal suture line on HRCT Temporal bone. The complications observed were skin infection (Holgers grade 2) around the site of implant in two patients, skin overgrowth due to more thickness of scalp (Holgers grade 4) in one of the patient. The patient had to undergo revision surgery to replace the abutment. And one of the patients underwent failure of osseointegration and was re-implanted later. Proper surgical technique and post operative wound care play an important role in avoiding complications. PMID:27508133

  7. Clinical Outcome of a Wide-diameter Bone-anchored Hearing Implant and a Surgical Technique With Tissue Preservation

    PubMed Central

    Mowinckel, Marius S.; Møller, Martin N.; Wielandt, Kirsten N.; Foghsgaard, Søren

    2016-01-01

    Objective: To investigate the clinical outcome of a surgical technique with tissue preservation for a wide bone-anchored hearing implant concerning postoperative complications, skin reactions, implant loss, and implant stability. Study Design: Consecutive, prospective case series. Setting: Tertiary referral center. Patients: Twenty-four adult patients with normal skin quality were enrolled. Intervention(s): Implantation of bone-anchored implant was performed using a one-stage linear-incision technique with tissue preservation surgery. Main Outcome Measures(s): Skin and soft tissue reactions according to Holgers grading system. Pain and numbness measured according to visual analogue scale. Implant stability quotient values were recorded using resonance frequency analysis. Follow-up at 10 days, 6 weeks, 6 months, and 1 year after surgery. Results: Primary implant stability was good and a significant increase in implant stability quotient occurred during the first 10 days and continued to be stable throughout the 1-year observation period. No implants were lost. Skin and soft tissue reactions were few, no reaction (Holger grade 0) was observed in 88% of the follow-up examinations and no grade 4 reactions occurred. Pain and numbness were minimal. Conclusion: The wide implant showed good stability initially and throughout the observation period. Skin and soft tissue reactions were rare and minor. No implants were lost. PMID:26954348

  8. The Bio-accessibility of Synthetic Fe-Organo Complexes in Subsurface Soil with Elevated Temperature: a Proxy for the Vulnerability of Mineral Associated Carbon to Warming Rachel C. Porras, Peter S. Nico, and Margaret Torn Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA

    NASA Astrophysics Data System (ADS)

    Porras, R. C.; Hicks Pries, C.

    2015-12-01

    Globally, subsurface soils (>30 cm) represent an important reservoir of soil organic carbon (SOC). However, the vulnerability of this deep SOC and, in particular mineral-associated SOC, to warming, and its potential to amplify the effects of climate change is highly uncertain. To gain insight into the bio-accessibility and temperature sensitivity of mineral-associated organic C, we conducted a series of incubations using soils collected from three depths (0-10, 50-60, and 80-90 cm) under coniferous forest. The soils are moderately acidic (mean pH=6.5) sandy, mixed, mesic Ultic Haploxeralfs. To understand how mechanisms controlling SOC bio-accessibilty or temperature sensitivity differ with depth and with the properties of Fe-organo complexes (i.e.,degree of crystallinity, amount of reactive surface area, or surface saturation), we used a 13C labeled glucose substrate to prepare synthetic Fe-organo complexes spanning a range of crystallinity and mineral surface saturation. The synthetic Fe-organo complexes were then added to soil from three depths. The soils containing the 13C labeled Fe-organo adduct were incubated at two temperatures (ambient and +4°C) and respired 13CO2 was measured and used to estimate flux rates. Differences in measured 13CO2 fluxes as a function of depth, surface loading, and mineral properties are discussed in terms of their implications for the temperature sensitivity of mineral protected organic carbon in subsurface soils.

  9. Power, Politics, Bilingual Education, and School Success. A Review of: "Language, Power and Pedagogy: Bilingual Children in the Crossfire" (Jim Cummins); "At War with Diversity: U.S. Language Policy in an Age of Anxiety" (James Crawford); and "The Politics of Multiculturalism and Bilingual Education: Students and Teachers Caught in the Cross Fire" (Carlos J. Ovando and Peter McLaren, Eds.).

    ERIC Educational Resources Information Center

    Reyhner, Jon

    2001-01-01

    Reviews three new books about the current political battle over bilingual education, focusing on: bilingual education theory and the importance of transformative pedagogy; political analysis of bilingual education and key issues in indigenous language loss; and politics of multiculturalism. Discusses the maturation of bilingual education since…

  10. Revolutionary Learning, Biodiversity, and Transformative Action. Essay Review of "Learning in Social Action: A Contribution To Understanding Informal Education" by Griff Foley; "Transformative Learning: Educational Vision for the Twenty-First Century" by Edmund O'Sullivan; and "Che Guevara, Paulo Freire and the Pedagogy of Revolution" by Peter McLaren.

    ERIC Educational Resources Information Center

    Mayo, Peter

    2001-01-01

    Three books, published 1999-2000, map out a vision of education as a vehicle for human emancipation and global transformation. Their approaches to presenting the "big picture" differ, focusing on case studies of learning through local social action; the impact of Che Guevara and Paulo Freire on liberation discourse worldwide; and comprehensive…

  11. EDITORIAL: Colloidal dispersions in external fields Colloidal dispersions in external fields

    NASA Astrophysics Data System (ADS)

    Löwen, Hartmut

    2012-11-01

    ller, Bastian Sieber, Holger Schweinfurth, Holger Reiber and Gerhard Nägele Electrokinetics on superhydrophobic surfacesPeriklis Papadopoulos, Xu Deng, Doris Vollmer and Hans-Jürgen Butt Numerical electrokineticsR Schmitz and B Dünweg Dielectric response of nanoscopic spherical colloids in alternating electric fields: a dissipative particle dynamics simulationJiajia Zhou and Friederike Schmid Self-assembly of colloidal particles into strings in a homogeneous external electric or magnetic fieldFrank Smallenburg, Hanumantha Rao Vutukuri, Arnout Imhof, Alfons van Blaaderen and Marjolein Dijkstra The nature of the laning transition in two dimensionsT Glanz and H Löwen Microscopic theory for anisotropic pair correlations in driven binary mixturesMatthias Kohl, Alexei V Ivlev, Philip Brandt, Gregor E Morfill and Hartmut Löwen Dynamics of individual colloidal particles in one-dimensional random potentials: a simulation studyRichard D L Hanes and Stefan U Egelhaaf An interacting dipole model to explore broadband transverse optical bindingMichael Mazilu, Andrew Rudhall, Ewan M Wright and Kishan Dholakia Comparison of 2D melting criteria in a colloidal systemPatrick Dillmann, Georg Maret and Peter Keim Effects of confinement and external fields on structure and transport in colloidal dispersions in reduced dimensionalityD Wilms, S Deutschländer, U Siems, K Franzrahe, P Henseler, P Keim, N Schwierz, P Virnau, K Binder, G Maret and P Nielaba Stochastic transport of particles across single barriersChristian Kreuter, Ullrich Siems, Peter Henseler, Peter Nielaba, Paul Leiderer and Artur Erbe A perspective on the interfacial properties of nanoscopic liquid dropsAlexandr Malijevský and George Jackson Controlling the wetting properties of the Asakura-Oosawa model and applications to spherical confinementA Statt, A Winkler, P Virnau and K Binder Crystalline multilayers of charged colloids in soft confinement: experiment versus theoryE C Oğuz, A Reinmüller, H J Schöpe, T Palberg, R

  12. Leptophlebiidae (Ephemeroptera) of the Serra do Tepequém, Roraima State, Brazil: new records and description of two new species.

    PubMed

    Neto, Jaime De Liege Gama; Hamada, Neusa

    2014-01-01

    Miroculis (Miroculis) eldorado sp. nov. and Ulmeritoides passorum sp. nov. are described based on material from Serra do Tepequém, Roraima State, Brazil. Additional records of Leptophlebiidae genera and species are made. Askola Peters, 1969, Farrodes Peters, 1971, Microphlebia Savage & Peters, 1983, Hydrosmilodon Flowers & Dominguez, 1992, Hagenulopsis minuta Spieth, 1943 and Simothraulopsis demerara (Traver, 1947) are recorded for the first time in Roraima State. Simothraulopsis janae Mariano, 2010 is recorded for the first time in the Northern Brazil. PMID:25543739

  13. 77 FR 65685 - Senior Executive Service Performance Review Board; Membership

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-30

    ... Innovation Cluster Program, Office of Research and Development; Joan Harrigan-Farrelly, Director... Management; Peter Jutro, Senior Scientist, National Homeland Security Research Center, Office of Research...

  14. The mathematics of movement

    USGS Publications Warehouse

    Johnson, D.H.

    1999-01-01

    Review of: Quantitative Analysis of Movement: Measuring and Modeling Population Redistribution in Animals and Plants. Peter Turchin. 1998. Sinauer Associates, Sunderland, MA. 306 pages. $38.95 (paper).

  15. 77 FR 50545 - Members of Senior Executive Service Performance Review Boards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ..., Director, International Operations (CI) Peter C. Wade, Business Modernization Director (W&I) Christopher Wagner, Chief, Appeals (AP) Richard Weber, Chief, CI Matthew A. Weir, Executive Director, Case...

  16. Too Much Talk

    ERIC Educational Resources Information Center

    Clark, Kenneth B.

    1971-01-01

    Dr. Kenneth Clark, interviewed by Dante Peter Ciochetto, discusses compensatory education, mobilization for reading and arithmetic in ghetto schools, and the Metropolitan Applied Research Center. (JM)

  17. 76 FR 70131 - Senior Executive Service Performance Review Board; Membership

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    .... Peter Jutro, Deputy Director for Policy, National Homeland Security Research Center, Office of Research...-Mullin, Deputy Director, National Homeland Security Research Center--Cincinnati, Ohio, Office of...

  18. PREFACE: International Symposium on (e,2e), Double Photoionization and Related Topics & 15th International Symposium on Polarization and Correlation in Electronic and Atomic Collisions

    NASA Astrophysics Data System (ADS)

    Martin, Nicholas L. S.; deHarak, Bruno A.

    2010-01-01

    44 submitted posters covered recent advances in these topics. These proceedings present papers on 35 of the invited talks. The Local Organizers gratefully acknowledge the financial support of the University of Kentucky College of Arts and Sciences, and the University of Kentucky Department of Physics and Astronomy. We also thank Carol Cotrill, Eva Ellis, Diane Yates, Sarah Crowe, and John Nichols, of the Department of Physics and Astronomy, University of Kentucky for their invaluable assistance in the smooth running of the conferences; Oleksandr Korneta for taking the group photograph; and Emily Martin for helping accompanying persons. Nicholas L S Martin University of Kentucky Bruno A deHarak Illinois Wesleyan University International Scientific Organizing Committee Co-Chairs Don Madison (USA)Klaus Bartschat (USA) Members Lorenzo Avaldi (Italy)Nils Andersen (Denmark) Jamal Berakdar (Germany)Uwe Becker (Germany) Michael Brunger (Australia)Igor Bray (Australia) Greg Childers (USA)Nikolay Cherepkov (Russia) JingKang Deng (China)Albert Crowe (UK) Alexander Dorn (Germany)Danielle Dowek (France) Jim Feagin (USA)Oscar Fojon (Argentina) Nikolay Kabachnik (Russia)Tim Gay (USA) Anatoli Kheifets (Australia)Alexei Grum-Grzhimailo (Russia) George King (UK)Friedrich Hanne (Germany) Tom Kirchner (Germany)Alan Huetz (France) Azzedine Lahmam-Bennani (France)Morty Khakoo (USA) Julian Lower (Australia)Birgit Lohmann (Australia) William McCurdy (USA)Bill McConkey (Canada) Andrew Murray (UK)Rajesh Srivastava (India) Bernard Piraux (Belgium)Al Stauffer (Canada) Tim Reddish (Canada)Jim Williams (Australia) Roberto Rivarola (Argentina)Akira Yagishita (Japan) Michael Schulz (USA)Peter Zetner (Canada) Anthony Starace (USA)Joachim Ullrich (Germany) Giovanni Stefani (Italy)Erich Weigold (Australia) Masahiko Takahashi (Japan) Conference photograph

  19. Near surface geophysics: application of FD-EMI sounding to the study of historical resources

    NASA Astrophysics Data System (ADS)

    Manstein, Yu. A.; Manstein, A. K.; Scozzari, A.

    2009-04-01

    archaeologists. Site # 15 of Cicah settlement is located in the Novosibirsk area. Cicah settlement is the large monument of Skyth culture. The general magnetic map of the settlement was made by Dr. Fassbinder and Dr. Becker. Then, many interesting spots were studied by NEMFIS to get more detailed information. Site # 15 was explored prior to excavation. The good correlation between NEMFIS signal distribution and the site inner structure can be seen. The area of Vengerovo town, located about 400 km West of Novosibirsk, was populated by various nomadic civilizations in the period between 3000-1000 B.C. The remains of such a nomadic life can be found all over the western Siberia as mounds, buried settlements, burial and ceremonial objects etc. Almost all of them were robbed in medieval ages and especially in XVIII century by expeditions launched by Peter the Great, Russian Emperor, to enrich his collection of ancient gold. As an example, Pogorelka is one of the typical mound presented at the area. Investigation of selected places in such areas is also discussed in this work.

  20. EDITORIAL: Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Hauptmann, Peter

    2009-01-01

    Marella de Angelis and her colleagues on precision gravimetry using atomic sensors and from Dr Peter Becker on determination of the Avogadro constant via enriched silicon-28. I recommend setting up a free e-mail alert so that you can read them as soon as they are published! As many of you are already aware, our impact factor (a measure of the average number of times recent papers are referred to by others) has risen again to 1.297. This is often taken as an indication of the quality and relevance of recently published research, and although as readers we develop our own instinct for journals of high quality, it is gratifying as an Editor to see the data from an independent organization (Thomson ISI) agreeing with my own assessment. Of course the publication of high quality articles in the journal is dependent both on you the authors who trust us with the publication of your best work and on our referees and Editorial Board Members who we depend on to maintain the high standards you have grown to expect. I must also thank our referees for their rapid response when asked to review papers for Measurement Science and Technology. On average, authors receive a decision on their article in 45 days. Therefore I would like to end this message by saying thank you again to all those who have contributed to our success in the past year, and wish you all the best for a successful 2009!