Science.gov

Sample records for horns rev offshore

  1. Analysis of long distance wakes of Horns Rev I using actuator disc approach

    NASA Astrophysics Data System (ADS)

    Eriksson, O.; Mikkelsen, R.; Hansen, K. S.; Nilsson, K.; Ivanell, S.

    2014-12-01

    The wake recovery behind the Horns Rev wind farm is analysed to investigate the applicability of Large Eddy Simulations (LES) in combination with an actuator disc method (ACD) for farm to farm interaction studies. Periodic boundary conditions on the lateral boundaries are used to model the wind farm (as infinitely wide), using only two columns of turbines. The meteorological conditions of the site are taken into account by introducing wind shear and pre-generated synthetic turbulence to the simulation domain using body forces. Simulations are carried out to study the power production and the velocity deficit in the farm wake. The results are compared to the actual power production as well as to wind measurements at 2 km and 6 km behind the wind farm. The simulated power production inside the farm shows an overall good correlation with the real production, but is slightly overpredicted in the most downstream rows. The simulations overpredict the wake recovery, namely the wind velocity, at long distances behind the farm. Further studies are needed before the presented method can be applied for the simulation of long distance wakes. Suggested parameters to be studied are the development of the turbulence downstream in the domain and the impact of the grid resolution.

  2. Session: Offshore wind

    SciTech Connect

    Gaarde, Jette; Ram, Bonnie

    2004-09-01

    This session at the Wind Energy and Birds/Bats workshop consisted of two presentations. Due to time constraints, a discussion period was not possible. The session addressed the current state of offshore wind energy development. The first presentation ''Monitoring Program and Results: Horns Rev and Nysted'' by Jette Gaarde summarized selected environmental studies conducted to date at operating offshore wind turbine projects in Denmark and lessons from other offshore wind developments in Europe. Wildlife impacts studies from the Danish sites focused on birds, fish, and mammals. The second presentation ''What has the U.S. Wind Industry Learned from the European Example'' by Bonnie Ram provided an update on current permit applications for offshore wind developments in the U.S. as well as lessons that may be drawn from the European experience.

  3. Geophysical data from offshore of the Gulf Islands National Seashore, Cat Island to Western Horn Island, Mississippi

    USGS Publications Warehouse

    Pendleton, E.A.; Baldwin, W.E.; Danforth, W.W.; DeWitt, N.T.; Forde, A.S.; Foster, D.S.; Kelso, K.W.; Pfeiffer, W.R.; Turecek, A.M.; Flocks, J.G.; Twichell, D.C.

    2011-01-01

    This report contains the geophysical and geospatial data that were collected along the western offshore side of the Gulf Islands of Mississippi on the research vessel Tommy Munro during two cruises in 2010. Geophysical data were collected by the U.S. Geological Survey in Woods Hole, Massachusetts, and St. Petersburg, Forida, in cooperation with the U.S. Army Corps of Engineers Mobile District. Bathymetric-sonar, sidescan-sonar, and Chirp seismic-reflection data were acquired with the following equipment, respectively: Systems Engineering and Assessment, Ltd., SwathPlus interferometric sonars; Klein 3000 and 3900 dual-frequency sidescan sonars; and an EdgeTech 512i Chirp sub-bottom profiling system. The long-term goals of this mapping effort are to produce high-quality, high-resolution geologic maps and interpretations that can be utilized to identify sand resources within the region, to better understand the Holocene evolution, and to anticipate future changes in this coastal system. Processed geospatial data files and the geophysical data provided in this report help attain these goals.

  4. Cutaneous Horn

    MedlinePlus

    ... fair-skinned individuals with a history of significant sun exposure. Signs and Symptoms A cutaneous horn most often ... radiation therapy. Trusted Links MedlinePlus: Skin Conditions MedlinePlus: Sun Exposure References Bolognia, Jean L., ed. Dermatology , pp.1715. ...

  5. Dielectrically loaded horns

    NASA Astrophysics Data System (ADS)

    Tun, S. M.; Bustamante, R.; Williams, N.

    Dielectrically loaded horns have been proposed as alternatives to conical corrugated horns in high-performance primary feeds in virtue both of their lower cost and theoretical indications of superior operational bandwidth performance, while retaining circularly symmetric radiation, low sidelobes, and low cross-polarization. A prototype dielectric core-loaded horn, and a dual-band transmit/receive horn antenna incorporating a dielectric rod inside a small corrugated horn, have been developed and tested; the dielectric used for the rod is Rexolite. The high performance obtainable by this inexpensive technology has been experimentally demonstrated.

  6. Wind Speed Estimation and Parametrization of Wake Models for Downregulated Offshore Wind Farms within the scope of PossPOW Project

    NASA Astrophysics Data System (ADS)

    Göçmen Bozkurt, Tuhfe; Giebel, Gregor; Kjølstad Poulsen, Niels; Mirzaei, Mahmood

    2014-06-01

    With increasing installed capacity, wind farms are requested to downregulate more frequently, especially in the offshore environment. Determination and verification of possible (or available) power of downregulated offshore wind farms are the aims of the PossPOW project (see PossPOW.dtu.dk). Two main challenges encountered in the project so far are the estimation of wind speed and the recreation of the flow inside the downregulated wind farm as if it is operating ideally. The rotor effective wind speed was estimated using power, pitch angle and rotational speed as inputs combined with a generic Cp model. The results have been compared with Horns Rev-I dataset and NREL 5MW simulations under both downregulation and normal operation states. For the real-time flow recreation, the GCLarsen single wake model was re-calibrated using a 1-s dataset from Horns Rev and tested for the downregulated period. The re-calibrated model has to be further parametrized to include dynamic effects such as wind direction variability and meandering also considering different averaging time scales before implemented in full scale wind farms.

  7. Using airborne and satellite SAR for wake mapping offshore

    NASA Astrophysics Data System (ADS)

    Christiansen, Merete B.; Hasager, Charlotte B.

    2006-09-01

    Offshore wind energy is progressing rapidly around Europe. One of the latest initiatives is the installation of multiple wind farms in clusters to share cables and maintenance costs and to fully exploit premium wind resource sites. For siting of multiple nearby wind farms, the wind turbine wake effect must be considered. Synthetic aperture radar (SAR) is an imaging remote sensing technique which offers a unique opportunity to describe spatial variations of wind speed offshore. For the first time an airborne SAR instrument was used for data acquisition over a large offshore wind farm. The aim was to identify the turbine wake effect from SAR-derived wind speed maps as a downstream region of reduced wind speed. The aircraft SAR campaign was conducted on 12 October 2003 over the wind farm at Horns Rev in the North Sea. Nearly simultaneous measurements were acquired over the area by the SAR on board the ERS-2 satellite. In addition, meteorological data were collected. Both aircraft and satellite SAR-derived wind speed maps showed significant velocity deficits downstream of the wind farm. Wind speed maps retrieved from aircraft SAR suggested deficits of up to 20% downstream of the last turbine, whereas satellite SAR-derived maps showed deficits of the order of 10%. The difference originated partly from the two different reference methods used for normalization of measured wind speeds. The detected region of reduced wind speed had the same width as the wind turbine array, indicating a low degree of horizontal wake dispersion. The downstream wake extent was approximately 10 km, which corresponds well with results from previous studies and with wake model predictions. Copyright

  8. The Ram's Horn.

    ERIC Educational Resources Information Center

    Rassias, John A., Ed.; And Others

    1983-01-01

    The summer-fall and winter-spring numbers of the journal, "The Ram's Horn," contain these articles: "The Text as Dramatic Departure"; "The Dartmouth Language Outreach Approach to Spanish for Police Action"; "The Dartmouth Intensive Language Model (DILM) in Florida: John Rassias with High School Teachers"; "The Flexibility of Using Drama Techniques…

  9. Comment on 'Quantum secret sharing based on reusable Greenberger-Horne-Zeilinger states as secure carriers'

    SciTech Connect

    Gao Fei; Guo Fenzhuo; Wen Qiaoyan; Zhu Fuchen

    2005-09-15

    In a recent paper [S. Bagherinezhad and V. Karimipour, Phys. Rev. A 67, 044302 (2003)], a quantum secret sharing protocol based on reusable Greenberger-Horne-Zeilinger states was proposed. However, in this Comment, it is shown that this protocol is insecure if Eve employs a special strategy to attack.

  10. Comment on ``Quantum secret sharing based on reusable Greenberger-Horne-Zeilinger states as secure carriers''

    NASA Astrophysics Data System (ADS)

    Gao, Fei; Guo, Fen-Zhuo; Wen, Qiao-Yan; Zhu, Fu-Chen

    2005-09-01

    In a recent paper [S. Bagherinezhad and V. Karimipour, Phys. Rev. A 67, 044302 (2003)], a quantum secret sharing protocol based on reusable Greenberger-Horne-Zeilinger states was proposed. However, in this Comment, it is shown that this protocol is insecure if Eve employs a special strategy to attack.

  11. Multi-mode horn

    NASA Technical Reports Server (NTRS)

    Neilson, Jeffrey M. (Inventor)

    2002-01-01

    A horn has an input aperture and an output aperture, and comprises a conductive inner surface formed by rotating a curve about a central axis. The curve comprises a first arc having an input aperture end and a transition end, and a second arc having a transition end and an output aperture end. When rotated about the central axis, the first arc input aperture end forms an input aperture, and the second arc output aperture end forms an output aperture. The curve is then optimized to provide a mode conversion which maximizes the power transfer of input energy to the Gaussian mode at the output aperture.

  12. Stacked Corrugated Horn Rings

    NASA Technical Reports Server (NTRS)

    Sosnowski, John B.

    2010-01-01

    This Brief describes a method of machining and assembly when the depth of corrugations far exceeds the width and conventional machining is not practical. The horn is divided into easily machined, individual rings with shoulders to control the depth. In this specific instance, each of the corrugations is identical in profile, and only differs in diameter and outer profile. The horn is segmented into rings that are cut with an interference fit (zero clearance with all machining errors biased toward contact). The interference faces can be cut with a reverse taper to increase the holding strength of the joint. The taper is a compromise between the interference fit and the clearance of the two faces during assembly. Each internal ring is dipped in liquid nitrogen, then nested in the previous, larger ring. The ring is rotated in the nest until the temperature of the two parts equalizes and the pieces lock together. The resulting assay is stable, strong, and has an internal finish that cannot be achieved through other methods.

  13. Comparing offshore wind farm wake observed from satellite SAR and wake model results

    NASA Astrophysics Data System (ADS)

    Bay Hasager, Charlotte

    2014-05-01

    Offshore winds can be observed from satellite synthetic aperture radar (SAR). In the FP7 EERA DTOC project, the European Energy Research Alliance project on Design Tools for Offshore Wind Farm Clusters, there is focus on mid- to far-field wind farm wakes. The more wind farms are constructed nearby other wind farms, the more is the potential loss in annual energy production in all neighboring wind farms due to wind farm cluster effects. It is of course dependent upon the prevailing wind directions and wind speed levels, the distance between the wind farms, the wind turbine sizes and spacing. Some knowledge is available within wind farm arrays and in the near-field from various investigations. There are 58 offshore wind farms in the Northern European seas grid connected and in operation. Several of those are spaced near each other. There are several twin wind farms in operation including Nysted-1 and Rødsand-2 in the Baltic Sea, and Horns Rev 1 and Horns Rev 2, Egmond aan Zee and Prinses Amalia, and Thompton 1 and Thompton 2 all in the North Sea. There are ambitious plans of constructing numerous wind farms - great clusters of offshore wind farms. Current investigation of offshore wind farms includes mapping from high-resolution satellite SAR of several of the offshore wind farms in operation in the North Sea. Around 20 images with wind farm wake cases have been retrieved and processed. The data are from the Canadian RADARSAT-1/-2 satellites. These observe in microwave C-band and have been used for ocean surface wind retrieval during several years. The satellite wind maps are valid at 10 m above sea level. The wakes are identified in the raw images as darker areas downwind of the wind farms. In the SAR-based wind maps the wake deficit is found as areas of lower winds downwind of the wind farms compared to parallel undisturbed flow in the flow direction. The wind direction is clearly visible from lee effects and wind streaks in the images. The wind farm wake cases

  14. Maximal violation of the Clauser-Horne-Shimony-Holt inequality for two qutrits

    SciTech Connect

    Fu, Li-Bin; Zhao, Xian-Geng; Chen, Jing-Ling

    2003-08-01

    The Bell-Clauser-Horne-Shimony-Holt (BCHSH) inequality (in terms of correlation functions) of two qutrits is studied in detail by employing tritter measurements. A uniform formula for the maximum value of this inequality for tritter measurements is obtained. Based on this formula, we show that nonmaximally entangled states violate the BCHSH inequality more strongly than the maximally entangled one. This result is consistent with what was obtained by Acin et al. [Phys. Rev. A 65, 052325 (2002)] using the Bell-Clauser-Horne inequality (in terms of probabilities)

  15. Ancient celtic horns

    NASA Astrophysics Data System (ADS)

    Campbell, Murray

    2002-11-01

    There is considerable evidence from iconographic and documentary sources that musical lip-reed instruments were important in the early celtic communities of Scotland and Ireland. In recent years several studies have been undertaken with the aim of gaining a better understanding of the musical nature of these ancient horns, and of their place in the life and culture of the time. A valuable source of tangible evidence is to be found in the archaeological remains deposited across Scotland and the whole of Ireland. A project is now under way, under the auspices of the Kilmartin House Trust and the general direction of John Purser, which has brought together an international team of musicians, craftsmen, archaeologists, musicologists and physicists with the aim of analyzing ancient musical artifacts, reconstructing some of the original instruments, and analyzing the sounds they produce. This paper describes acoustical studies carried out on a number of recent reconstructions of wooden and bronze instruments, and discusses the role of acoustics in this type of investigation. [Work supported by Sciart and EPSRC.

  16. Using Synthetic Aperture Radar Wind Measurements to support Offshore Wind Parks

    NASA Astrophysics Data System (ADS)

    Schneiderhan, T.; Lehner, S.; Horstmann, J.; Koch, W.; Schulz-Stellenfleth, J.

    2003-04-01

    In all countries with shallow coastal waters and a strong mean wind speed offshore wind parks are planned and built. The fast development of wind energy production in Europe led to an installation of more than 18 000 MW by the end of the year 2001. The installed offshore power up to date is about 100 MW. In the near future many projects for wind farms with an output of more than 5000 MW are planned. Some of these projects are already under construction. Offshore wind parks are showing a big potential for future energy production and solving ecological problems in reducing the CO^2 output. The construction and maintenance of offshore wind parks has to face the tough environmental conditions of the open sea resulting extensive maintenance and money. Therefore reliable forecast in particular of the wind and the ocean wave fields is essential. Space borne SAR data as acquired by the ERS satellites or the new ENVISAT satellite, launched in March 2002, provide two dimensional wind fields with a sub-kilometre resolution and a coverage of up to 500 by 500 km in the wide swath mode. They are thus ideally suited to investigate the spatial fine structure like e.g. turbulence in the wake of wind parks, which is an important factor in the optimal siting of wind farms. Due to their high coverage and resolution SAR data can provide information on the impact of the single turbines on the wind field experienced by the neighbouring turbines as well as the effect of the whole wind park on the local climate. This study shows the potential of two dimensional high resolution wind fields measured with space borne synthetic aperture radar to support the construction and operation of wind farms. The data can be used to minimize fatigue loading due to wind gusts as well as to provide short term power forecasts in order to optimise the power output. Examples of wind fields around the already existing offshore wind parks Utgrunden (South of Sweden) and Horns Rev (West of Denmark) and the

  17. Successful outcome in preeclamptic rudimentary horn pregnancy

    PubMed Central

    Sinha, Ruchi; Sachan, Shikha; Khanna, Anuradha

    2011-01-01

    Unicornuate uterus with rudimentary horn is an uncommon type of mullerian duct malformation associated with various gynecological and obstetrical complications. Rudimentary horn pregnancy is a rare entity and the majority have rupture of gravid horn leading to maternal and fetal morbidity and mortality. A case of rudimentary horn pregnancy at 32 weeks and 6 days with pregnancy induced hypertension is reported where proper management results in successful pregnancy outcome. PMID:24591959

  18. Successful outcome in preeclamptic rudimentary horn pregnancy.

    PubMed

    Sinha, Ruchi; Sachan, Shikha; Khanna, Anuradha

    2011-01-01

    Unicornuate uterus with rudimentary horn is an uncommon type of mullerian duct malformation associated with various gynecological and obstetrical complications. Rudimentary horn pregnancy is a rare entity and the majority have rupture of gravid horn leading to maternal and fetal morbidity and mortality. A case of rudimentary horn pregnancy at 32 weeks and 6 days with pregnancy induced hypertension is reported where proper management results in successful pregnancy outcome. PMID:24591959

  19. Trichomoniasis in great horned owls.

    PubMed

    Jessup, D A

    1980-07-01

    Three cases of Trichomonas gallinae infection of deep tissues of the skull or of unusual tissues in great horned owls (Bubo virginianus), refractory to recommended doses but responsive to higher doses of dimetridazole, are discussed. Trichomonads were isolated from the lesions. PMID:7432340

  20. ELECTROMIGRATION ISSUES IN HIGH CURRENT HORN.

    SciTech Connect

    ZHANG, S.Y.; BELLAVIA, S.; SANDBERG, J.; ET AL.

    2005-05-16

    The secondary particle focusing horn for the AGS neutrino experiment proposal is a high current and high current density device. The peak current of horn is 300 kA. At the smallest area of horn, the current density is near 8 kA/mm{sup 2}. At very high current density, a few kA/mm{sup 2}, the electromigration phenomena will occur. Momentum transfer between electrons and metal atoms at high current density causes electromigration. The reliability and lifetime of focusing horn can be severely reduced by electromigration. In this paper, we discuss issues such as device reliability model, incubation time of electromigration, and lifetime of horn.

  1. Folded Resonant Horns for Power Ultrasonic Applications

    NASA Technical Reports Server (NTRS)

    Sherrit, Stewart; Askins, Stephen; Gradziel, Michael; Bao, Xiaoqi; Chang, Zensheu; Dolgin, Benjamin; Bar-Cohen, Yoseph; Peterson, Tom

    2003-01-01

    Folded horns have been conceived as alternatives to straight horns used as resonators and strain amplifiers in power ultrasonic systems. Such systems are used for cleaning, welding, soldering, cutting, and drilling in a variety of industries. In addition, several previous NASA Tech Briefs articles have described instrumented drilling, coring, and burrowing machines that utilize combinations of sonic and ultrasonic vibrational actuation. The main advantage of a folded horn, relative to a straight horn of the same resonance frequency, is that the folded horn can be made shorter (that is, its greatest linear dimension measured from the outside can be made smaller). Alternatively, for a given length, the resonance frequency can be reduced. Hence, the folded-horn concept affords an additional degree of design freedom for reducing the length of an ultrasonic power system that includes a horn.

  2. Wind Speed Estimation and Wake model Re-calibration for Downregulated Offshore Wind Farms

    NASA Astrophysics Data System (ADS)

    Göçmen Bozkurt, Tuhfe; Giebel, Gregor; Kjølstad Poulsen, Niels; Réthoré, Pierre-Elouan; Mirzaei, Mahmood

    2014-05-01

    In recent years, the wind farm sizes have increased tremendously and with increasing installed capacity, the wind farms are requested to downregulate from their maximum possible power more frequently, especially in the offshore environment. Determination of the possible (or available) power is crucial not only because the reserve power has considerable market value but also for wind farm developers to be properly compensated for the loss during downregulation. While the available power calculation is straightforward for a single turbine, it gets rather complicated for the whole wind farm due to the change in the wake characteristics. In fact, the wake losses generated by the upstream turbine(s) decrease during downregulation and the downstream turbines therefore see more wind compared to the normal operation case. Currently, the Transmission System Operators (TSOs) have no real way to determine exactly the available power of a whole wind farm which is downregulated. Therefore, the PossPOW project aims to develop a verified and internationally accepted way to determine the possible power of a down-regulated offshore wind farm. The first phase of the project is to estimate the rotor effective wind speed. Since the nacelle anemometers are not readily available and are known to have reliability issues, the proposed method is to use power, pitch angle and rotational speed as inputs and combine it with a generic Cp model to estimate the wind speed. The performance of the model has been evaluated for both normal operation and downregulation periods using two different case studies: Horns Rev-I wind farm and NREL 5MW single turbine. During downregulation, the wake losses are not as severe and the velocity deficits at the downstream turbines are smaller as if also the wake is "downregulated". On the other hand, in order to calculate the available power, the wakes that would have been produced normally (if the turbines were not curtailed) are of importance, not the

  3. Novel Horn Designs for Power Ultrasonics

    NASA Technical Reports Server (NTRS)

    Sherrit, Stewart; Badescu, M.; Bao, X.; Bar-Cohen, Y.; Chang, Z.

    2004-01-01

    Ultrasonic horns are used in a variety of industrial and medical applications. At JPL a rock-sampling tool based on an ultrasonic horn was developed to drill, abrade and core rock samples including hard basalts. This device is an impact device, which uses ultrasonic vibratlons that occur at the horn tip to produce a sonic resonance with the aid of a loosely connected mass. Although standard horns are found in many current industrial designs they suffer from a few key limitations when used for USDC applications. Manufacturing a horn requires turning down stock material (e.g. Titanium) from the larger outer diameter to the horn tip diameter, and this process is both time consuming and wasteful. In this paper, we present novel horn designs that are specifically designed for impact applications as the USDC. One such design addressed the excasive length that is involved with the use of the horn limiting its applications when system dimensions are constrained. For this purpose, a folded horn design was conceived that reduces the overall length of the resonator (physical length) but maintains or increases the acoustic length. Initial experiments with horns having such P design indicate that the tip displacement can be further adjusted by phasing the bending displacements and the extensional displacements. Another conceived horn design is the 'dog bone' horn that uses an end mass on the horn tip io increase the impact efficiency of the horn. In this paper, the experimental results for these novel born designs are presented and compared to the results predicted by theory.

  4. Multifrequency broadband polarized horn antenna

    NASA Technical Reports Server (NTRS)

    Green, K. A. (Inventor)

    1981-01-01

    A corrugated conical horn antenna is simultaneously fed a multiplicity of signals, two for each of five frequencies, with each of a pair of signals fed in each of two orthogonal planes for excitation of a desired spherical hybrid mode. The lowest frequency is fed into the horn through orthogonal pairs of colinear slots, each pair being fed by coaxial tee power dividers. Other signals are fed through a circular waveguide connected to the vertex. The highest frequency signals are fed through orthogonal ports near the far end of the circular waveguide. The intermediate frequency signals are fed through orthogonal ports spaced along the waveguide. Filtering is incorporated for each to maintain isolation and low insertion loss.

  5. Multifrequency broadband polarized horn antenna

    NASA Astrophysics Data System (ADS)

    Green, K. A.

    1981-03-01

    A corrugated conical horn antenna is simultaneously fed a multiplicity of signals, two for each of five frequencies, with each of a pair of signals fed in each of two orthogonal planes for excitation of a desired spherical hybrid mode. The lowest frequency is fed into the horn through orthogonal pairs of colinear slots, each pair being fed by coaxial tee power dividers. Other signals are fed through a circular waveguide connected to the vertex. The highest frequency signals are fed through orthogonal ports near the far end of the circular waveguide. The intermediate frequency signals are fed through orthogonal ports spaced along the waveguide. Filtering is incorporated for each to maintain isolation and low insertion loss.

  6. Printed sectoral horn power combiner

    NASA Astrophysics Data System (ADS)

    Boccia, Luigi; Emanuele, Antonio; Shamsafar, Alireza; Arnieri, Emilio; Amendola, Giandomenico

    2015-02-01

    In this work, it is presented a new configuration of planar power combiner/divider based on an H-plane sectoral horn antenna. This component is proposed to realise the basic building blocks of printed power-combining amplifiers. It will be shown how the sectoral horn elements can be implemented on substrate integrated waveguide and multilayer printed circuit board technologies, thus obtaining a high integration level. In the following, the design procedure will be described reporting an example of an 11-stage power divider/combiner in C-band. A prototype has been fabricated, and the measured results compared with the numerical model. Experimental results are in good agreement with theoretical expectations showing a single-stage efficiency of about 90% and a bandwidth of 40%.

  7. Irreducible multiqutrit correlations in Greenberger-Horne-Zeilinger-type states

    SciTech Connect

    Zhang, Fu-Lin; Chen, Jing-Ling

    2011-12-15

    Following the idea of the continuity approach by D. L. Zhou [Phys. Rev. Lett. 101, 180505 (2008)], we obtain the degrees of irreducible multiparty correlations in two families of n-qutrit Greenberger-Horne-Zeilinger-type states. For the pure states in one of the families, the irreducible 2-party, n-party, and (n-m)-party (0

  8. Miniaturization of Planar Horn Motors

    NASA Technical Reports Server (NTRS)

    Sherrit, Stewart; Ostlund, Patrick N.; Chang, Zensheu; Bao, Xiaoqi; Bar-Cohen, Yoseph; Widholm, Scott E.; Badescu, Mircea

    2012-01-01

    There is a great need for compact, efficient motors for driving various mechanisms including robots or mobility platforms. A study is currently underway to develop a new type of piezoelectric actuators with significantly more strength, low mass, small footprint, and efficiency. The actuators/motors utilize piezoelectric actuated horns which have a very high power density and high electromechanical conversion efficiency. The horns are fabricated using our recently developed novel pre-stress flexures that make them thermally stable and increases their coupling efficiency. The monolithic design and integrated flexures that pre-stresses the piezoelectric stack eliminates the use of stress bolt. This design allows embedding solid-state motors and actuators in any structure so that the only macroscopically moving parts are the rotor or the linear translator. The developed actuator uses a stack/horn actuation and has a Barth motor configuration, which potentially generates very large torque and speeds that do not require gearing. Finite element modeling and design tools were investigated to determine the requirements and operation parameters and the results were used to design and fabricate a motor. This new design offers a highly promising actuation mechanism that can potentially be miniaturized and integrated into systems and structures. It can be configured in many shapes to operate as multi-degrees of freedom and multi-dimensional motors/actuators including unidirectional, bidirectional, 2D and 3D. In this manuscript, we are reporting the experimental measurements from a bench top design and the results from the efforts to miniaturize the design using 2x2x2 mm piezoelectric stacks integrated into thin plates that are of the order of3 x 3x 0.2 cm.

  9. Teleportation of continuous variable multimode Greeberger Horne Zeilinger entangled states

    NASA Astrophysics Data System (ADS)

    He, Guangqiang; Zhang, Jingtao; Zeng, Guihua

    2008-11-01

    Quantum teleportation protocols of continuous variable (CV) Greeberger-Horne-Zeilinger (GHZ) and Einstein-Podolsky-Rosen (EPR) entangled states are proposed, and are generalized to teleportation of arbitrary multimode GHZ entangled states described by Van Loock and Braunstein (2000 Phys. Rev. Lett. 84 3482). Each mode of a multimode entangled state is teleported using a CV EPR entangled pair and classical communication. The analytical expression of fidelity for the multimode Gaussian states which evaluates the teleportation quality is presented. The analytical results show that the fidelity is a function of both the squeezing parameter r, which characterizes the multimode entangled state to be teleported, and the channel parameter p, which characterizes the EPR pairs shared by Alice and Bob. The fidelity increases with increasing p, but decreases with increasing r, i.e., it is more difficult to teleport the more perfect multimode entangled states. The entanglement degree of the teleported multimode entangled states increases with increasing both r and p. In addition, the fact is proved that our teleportation protocol of EPR entangled states using parallel EPR pairs as quantum channels is the best case of the protocol using four-mode entangled states (Adhikari et al 2008 Phys. Rev. A 77 012337).

  10. 49 CFR 229.129 - Locomotive horn.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Locomotive horn. 229.129 Section 229.129 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Cabs and Cab Equipment § 229.129 Locomotive horn. (a) Each...

  11. Rudimentary horn pregnancy: prerupture diagnosis and management.

    PubMed

    Chopra, Seema; Suri, Vanita; Aggarwal, Neelam

    2007-01-01

    A unicornuate uterus with a rudimentary horn is a rare mullerian abnormality which may cause many gynecological and obstetrical complications. Rupture of pregnant rudimentary horn in the second trimester is the usual presentation, resulting in maternal morbidity and even mortality. PMID:17197736

  12. High-Aperture-Efficiency Horn Antenna

    NASA Technical Reports Server (NTRS)

    Pickens, Wesley; Hoppe, Daniel; Epp, Larry; Kahn, Abdur

    2005-01-01

    A horn antenna (see Figure 1) has been developed to satisfy requirements specific to its use as an essential component of a high-efficiency Ka-band amplifier: The combination of the horn antenna and an associated microstrip-patch antenna array is required to function as a spatial power divider that feeds 25 monolithic microwave integrated-circuit (MMIC) power amplifiers. The foregoing requirement translates to, among other things, a further requirement that the horn produce a uniform, vertically polarized electromagnetic field in its patches identically so that the MMICs can operate at maximum efficiency. The horn is fed from a square waveguide of 5.9436-mm-square cross section via a transition piece. The horn features cosine-tapered, dielectric-filled longitudinal corrugations in its vertical walls to create a hard boundary condition: This aspect of the horn design causes the field in the horn aperture to be substantially vertically polarized and to be nearly uniform in amplitude and phase. As used here, cosine-tapered signifies that the depth of the corrugations is a cosine function of distance along the horn. Preliminary results of finite-element simulations of performance have shown that by virtue of the cosine taper the impedance response of this horn can be expected to be better than has been achieved previously in a similar horn having linearly tapered dielectric- filled longitudinal corrugations. It is possible to create a hard boundary condition by use of a single dielectric-filled corrugation in each affected wall, but better results can be obtained with more corrugations. Simulations were performed for a one- and a three-corrugation cosine-taper design. For comparison, a simulation was also performed for a linear- taper design (see Figure 2). The three-corrugation design was chosen to minimize the cost of fabrication while still affording acceptably high performance. Future designs using more corrugations per wavelength are expected to provide better

  13. Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function

    SciTech Connect

    Cochrane, Alan; Murley, Laura Lea; Gao Mian; Wong, Raymond; Clayton, Kiera; Brufatto, Nicole; Canadien, Veronica; Mamelak, Daniel; Chen, Tricia; Richards, Dawn; Zeghouf, Mahel; Greenblatt, Jack; Burks, Christian; Frappier, Lori

    2009-05-25

    The Rev protein of HIV-1 is essential for HIV-1 proliferation due to its role in exporting viral RNA from the nucleus. We used a modified version of tandem affinity purification (TAP) tagging to identify proteins interacting with HIV-1 Rev in human cells and discovered a prominent interaction between Rev and nucleosome assembly protein 1 (Nap1). This interaction was also observed by specific retention of Nap1 from human cell lysates on a Rev affinity column. Nap1 was found to bind Rev through the Rev arginine-rich domain and altered the oligomerization state of Rev in vitro. Overexpression of Nap1 stimulated the ability of Rev to export RNA, reduced the nucleolar localization of Rev, and affected Rev nuclear import rates. The results suggest that Nap-1 may influence Rev function by increasing the availability of Rev.

  14. The SeaHorn Verification Framework

    NASA Technical Reports Server (NTRS)

    Gurfinkel, Arie; Kahsai, Temesghen; Komuravelli, Anvesh; Navas, Jorge A.

    2015-01-01

    In this paper, we present SeaHorn, a software verification framework. The key distinguishing feature of SeaHorn is its modular design that separates the concerns of the syntax of the programming language, its operational semantics, and the verification semantics. SeaHorn encompasses several novelties: it (a) encodes verification conditions using an efficient yet precise inter-procedural technique, (b) provides flexibility in the verification semantics to allow different levels of precision, (c) leverages the state-of-the-art in software model checking and abstract interpretation for verification, and (d) uses Horn-clauses as an intermediate language to represent verification conditions which simplifies interfacing with multiple verification tools based on Horn-clauses. SeaHorn provides users with a powerful verification tool and researchers with an extensible and customizable framework for experimenting with new software verification techniques. The effectiveness and scalability of SeaHorn are demonstrated by an extensive experimental evaluation using benchmarks from SV-COMP 2015 and real avionics code.

  15. Microstructure and mechanical properties of sheep horn.

    PubMed

    Zhu, Bing; Zhang, Ming; Zhao, Jian

    2016-07-01

    The sheep horn presents outstanding mechanical properties of impact resistance and energy absorption, which suits the need of the vehicle bumper design, but the mechanism behind this phenomenon is less investigated. The microstructure and mechanical properties of the sheep horn of Small Tailed Han Sheep (Ovis aries) living in northeast China were investigated in this article. The effect of sampling position and orientation of the sheep horn sheath on mechanical properties were researched by tensile and compression tests. Meanwhile, the surface morphology and microstructure of the sheep horn were observed using scanning electron microscopy (SEM). The formation mechanism of the mechanical properties of the sheep horn was investigated by biological coupling analysis. The analytical results indicated that the outstanding mechanical properties of the sheep horn are determined by configuration, structure, surface morphology and material coupling elements. These biological coupling elements make the sheep horn possess super characteristics of crashworthiness and energy absorption through the internal coupling mechanism. We suppose that these findings would make a difference in vehicle bumper design. Microsc. Res. Tech. 79:664-674, 2016. © 2016 Wiley Periodicals, Inc. PMID:27184115

  16. Audibility of train horns in passenger vehicles.

    PubMed

    Dolan, Thomas G; Rainey, Jess E

    2005-01-01

    Studies of accident rates associated with train horn bans indicate that motorists rely on horns to warn them of approaching trains. However, researchers have not yet established the levels of horn sounds necessary for detection at railroad crossings. The purpose of this study was to obtain baseline measures of the auditory component of the motorist's detection task. Horn sounds recorded in three test vehicles were presented to 20 normal-hearing listeners in quiet and in four types of vehicle interior noise: engine idling, ventilation fan off; engine idling, fan on; vehicle moving at 30 miles/hr (mph), fan off; and vehicle moving at 30 mph, fan on. Thresholds of the horn sounds were determined by an adaptive procedure. Mean thresholds were lowest in quiet (1.8-4.4 dBA) and highest for the 30-mph, fan-on condition (49.7-58.4 dBA). Mean horn thresholds for all 12 noise conditions were more than 10 dB below the overall level of the vehicle interior noise. Our data are compared with those of previous studies and their implications are discussed. Actual or potential applications of this research include the establishment of a lower limit of signal-to-noise ratios required for the detection of horn sounds at highway-rail crossings. PMID:16435701

  17. Keynote Address: Rev. Mark Massa

    ERIC Educational Resources Information Center

    Massa, Mark S.

    2011-01-01

    Rev. Mark S. Massa, S.J., is the dean and professor of Church history at the School of Theology and Ministry at Boston College. He was invited to give a keynote to begin the third Catholic Higher Education Collaborative Conference (CHEC), cosponsored by Boston College and Fordham University. Fr. Massa's address posed critical questions about…

  18. An Annotated Guide and Interactive Database for Solo Horn Repertoire

    ERIC Educational Resources Information Center

    Schouten, Sarah

    2012-01-01

    Given the horn's lengthy history, it is not surprising that many scholars have examined the evolution of the instrument from the natural horn to the modern horn and its expansive repertoire. Numerous dissertations, theses, and treatises illuminate specific elements of the horn's solo repertoire; however, no scholar has produced a…

  19. Laparoscopic Resection of Unruptured Rudimentary Horn Pregnancy.

    PubMed

    Sharma, Deepti; Usha, M G; Gaikwad, Ramesh; Sudha, S

    2011-01-01

    A non-communicating rudimentary horn is an uncommon site for ectopic pregnancy. Rudimentary horn pregnancy (RHP) is a rare entity but associated with grave clinical consequences. Majority of these cases if not detected timely end up in uterine rupture and present as an obstetrical emergency. We present this case of a 32-year-old, third gravida with a 12 weeks live gestation in the right rudimentary horn, which was successfully managed with laparoscopic resection. Early diagnosis is the key stone in the management of such cases. Laparoscopic resection is a safe and viable option in the surgical management of unruptured RHP. PMID:26085754

  20. Ruptured rudimentary horn at 22 weeks.

    PubMed

    Dhar, Hansa

    2012-07-01

    Rudimentary horn is a developmental anomaly of the uterus. Pregnancy in a non-communicating rudimentary horn is very difficult to diagnose before it ruptures. A case of undiagnosed rudimentary horn pregnancy at 22 weeks presented to Nizwa regional referral hospital in shock with features of acute abdomen. Chances of rupture in first or second trimester are increased with catastrophic haemorrhage leading to increased maternal and perinatal morbidity and mortality. Management of such cases is a challenge till today due to diagnostic dilemma. Expertise in ultrasonography and early resort to surgical management is life saving in such cases. PMID:23293421

  1. Ruptured rudimentary horn pregnancy at sixteen weeks.

    PubMed

    Zeqiri, Fehmi; Paçarada, Myrvete; Kongjeli, Niltene; Zeqiri, Vlora; Kongjeli, Gyltene; Krasniqi, Burim

    2010-01-01

    Pregnancy in a non-communicating rudimentary horn is very difficult to diagnose before it ruptures, leading to life -threatening intraperitoneal hemorrhage. A 22-year-old second gravida patient presented at the Emergency Center of the University Clinical Center of Kosova with a 16-week history of amenorrhea and acute onset of severe abdominal pain. She was resuscitated and taken for an emergency laparotomy under general anesthesia. Intraoperatively, there was a massive hemoperitoneum with a ruptured right rudimentary horn Given their rarity, ruptured rudimentary horn pregnancies are of interest. PMID:24591927

  2. Rupture of non-communicating rudimentary uterine horn pregnancy.

    PubMed

    Dhar, Hansa

    2008-01-01

    Unicornuate uterus with rudimentary horn is a rare type of uterine malformation associated with obstetrical complications. Rupture of pregnant rudimentary horn is the usual presentation resulting in severe haemoperitoneum with increased maternal morbidity, and at times, mortality. A case of ruptured rudimentary horn pregnancy in a 24-year-old, second gravida, is reported. Exploratory laparotomy revealed a ruptured rudimentary horn pregnancy of 14 weeks gestation with haemoperitoneum. Excision of the rudimentary horn was done and an uneventful recovery followed. PMID:18452672

  3. 802GHz integrated horn antennas imaging array

    NASA Astrophysics Data System (ADS)

    Ali-Ahmad, Walid Y.; Rebeiz, Gabriel M.; Dave, Hemant; Chin, Gordon

    1991-05-01

    Pattern measurements at 802GHz of a single element in 256-element integrated horn imaging array are presented. The integrated-horn antenna consists of a dipole-antenna suspended on a 1-micron dielectric membrane inside a pyramidal cavity etched in silicon. The theoretical far-field patterns, calculated using reciprocity and Floquet-modes representation of the free-space field, agree well with the measured far-field patterns at 802GHz. The associated directivity for a 1.40 lambda horn aperture, calculated from the measured E and H-plane patterns is 12.3dB + or - 0.2dB. This work demonstrates that high-efficiency integrated-horn antennas are easily scalable to terahertz frequencies and could be used for radio-astronomical and plasma-diagnostic applications.

  4. Non-communicating rudimentary uterine horn pregnancy.

    PubMed

    Upadhyaya, I

    2011-01-01

    Pregnancy in a non-communicating rudimentary horn is an extremely rare form of ectopic gestation. The rudimentary horn may or may not communicate with the uterine cavity with the majority of cases being non-communicating. The patient exhibits features of acute abdomen and carries a high risk of maternal death. Even modern scans remain elusive whereas laparatomy remains the confirmatory procedure for the diagnosis. Because of the varied muscular constitution in the thickness and distensibility of the wall of the rudimentary horn, pregnancy is accommodated for a variable period of gestation. Here, we report three cases of pregnancy in a non-communicating rudimentary horn of the uterus in different periods of gestation, their outcome and a review of the available literature. PMID:22922902

  5. Radiation from Axisymmetric Waveguide Fed Horns

    NASA Technical Reports Server (NTRS)

    Chinn, G. C.; Hoppe, D. J.; Epp, L. W.

    1995-01-01

    Return losses and radiation patterns for axisymmetric waveguide fed horns are calculated with the finite element method (FEM) in conjunction with the method of moments (MoM) and the mode matching technique (MM).

  6. Planar Rotary Piezoelectric Motor Using Ultrasonic Horns

    NASA Technical Reports Server (NTRS)

    Sherrit, Stewart; Bao, Xiaoqi; Badescu, Mircea; Bar-Cohen, Yoseph; Geiyer, Daniel; Ostlund, Patrick N.; Allen, Phillip

    2011-01-01

    A motor involves a simple design that can be embedded into a plate structure by incorporating ultrasonic horn actuators into the plate. The piezoelectric material that is integrated into the horns is pre-stressed with flexures. Piezoelectric actuators are attractive for their ability to generate precision high strokes, torques, and forces while operating under relatively harsh conditions (temperatures at single-digit K to as high as 1,273 K). Electromagnetic motors (EM) typically have high rotational speed and low torque. In order to produce a useful torque, these motors are geared down to reduce the speed and increase the torque. This gearing adds mass and reduces the efficiency of the EM. Piezoelectric motors can be designed with high torques and lower speeds directly without the need for gears. Designs were developed for producing rotary motion based on the Barth concept of an ultrasonic horn driving a rotor. This idea was extended to a linear motor design by having the horns drive a slider. The unique feature of these motors is that they can be designed in a monolithic planar structure. The design is a unidirectional motor, which is driven by eight horn actuators, that rotates in the clockwise direction. There are two sets of flexures. The flexures around the piezoelectric material are pre-stress flexures and they pre-load the piezoelectric disks to maintain their being operated under compression when electric field is applied. The other set of flexures is a mounting flexure that attaches to the horn at the nodal point and can be designed to generate a normal force between the horn tip and the rotor so that to first order it operates independently and compensates for the wear between the horn and the rotor.

  7. Evolutionary design of corrugated horn antennas

    NASA Technical Reports Server (NTRS)

    Hoorfar, F.; Manshadi, V.; Jamnejad, A.

    2002-01-01

    An evolutionary progranirnitzg (EP) algorithm is used to optimize pattern of a corrugated circularhorn subject to various constraints on return loss and antenna beamwidth and pattern circularity and low crosspolarization. The EP algorithm uses a Gaussian mutation operator. Examples on design synthesis of a 45 section corrugated horn, with a total of 90 optimization parameters, are presented. The results show excellent and efficient optimization of the desired horn parameters.

  8. Placenta accreta in a separate uterine horn.

    PubMed

    Baughn, Mariah R; Vaux, Keith; Masliah, Eliezer

    2010-01-01

    We report the case of a 30-year-old woman who presented with intrauterine fetal demise of a 17-2/7-week male fetus. The patient failed misoprostol induction and was taken for surgical evaluation. At the time of surgery an ectopic pregnancy in a noncommunicating rudimentary uterine horn was found. Histologic examination of the excised remnant uterine horn showed there was a placenta accreta. PMID:19642813

  9. Pregnancy in rudimentary horn of uterus.

    PubMed

    Kulkarni, Kranti; Ajmera, Sachin

    2013-01-01

    A 20-year-old primigravida with 3 months amenorrhea presented with complaints of acute abdominal pain. Her vital systemic parameters were stable. On vaginal examination, the patient was provisionally diagnosed of right cornual ectopic pregnancy, which was confirmed sonographically, and taken up for surgery. There was moderate hemoperitoneum and rupture of right horn of uterus with products protruding. The rudimentary horn was excised. The patient was discharged and advised contraception and follow-up. PMID:24178341

  10. [Penile cutaneous horn. A clinical case].

    PubMed

    Conde Sánchez, J M; Rico López, J; Blasco Hernández, P; Espinosa Olmedo, J; Domínguez Domínguez, M; García Pérez, M

    2000-02-01

    Contribution of a case report of cutaneous horn of penis surgically treated with extensive resection of the implantation base. A well differentiated, microinvasive epidermoid carcinoma was histopathologically demonstrated on a hyperkeratosis squamous papilloma. Although underlying lesions to cutaneous horn are usually benign, malignant changes have been reported in up to one third of cases; surgical treatment should therefore include extensive resection of the implantation base. PMID:10829451

  11. Sum-of-squares decompositions for a family of Clauser-Horne-Shimony-Holt-like inequalities and their application to self-testing

    NASA Astrophysics Data System (ADS)

    Bamps, Cédric; Pironio, Stefano

    2015-05-01

    We introduce two families of sum-of-squares (SOS) decompositions for the Bell operators associated with the tilted Clauser-Horne-Shimony-Holt (CHSH) expressions introduced in Acín et al. [Phys. Rev. Lett. 108, 100402 (2012), 10.1103/PhysRevLett.108.100402]. These SOS decompositions provide tight upper bounds on the maximal quantum value of these Bell expressions. Moreover, they establish algebraic relations that are necessarily satisfied by any quantum state and observables yielding the optimal quantum value. These algebraic relations are then used to show that the tilted CHSH expressions provide robust self-tests for any partially entangled two-qubit state. This application to self-testing follows closely the approach of Yang and Navascués [Phys. Rev. A 87, 050102(R) (2013), 10.1103/PhysRevA.87.050102], where we identify and correct two nontrivial flaws.

  12. Ruptured ectopic pregnancy in rudimentary horn of the uterus.

    PubMed

    Tufail, Amber; Hashmi, Haleema A

    2007-02-01

    Rudimentary horn is one of the rarest congenital uterine anomalies and consists of a relatively normal appearing uterus on one side with a rudimentary horn on the other side. It is difficult to diagnose before surgery and hazardous to maternal life as rupture of pregnant horn result in severe hemoperitoneum. Case of rudimentary horn pregnancy is reported in a lady with history of habitual abortion and signs and symptoms of acute adnexal pathology. Exploratory laparotomy revealed ruptured rudimentary horn pregnancy. Excision of accessory horn was done. PMID:17288859

  13. The rams horn in western history

    NASA Astrophysics Data System (ADS)

    Lubman, David

    2003-10-01

    The shofar or rams horn-one of the most ancient of surviving aerophones-may have originated with early Neolithic herders. The shofar is mentioned frequently and importantly in the Hebrew bible and in later biblical and post-biblical literature. Despite its long history, contemporary ritual uses, and profound symbolic significance to western religion, no documentation of shofar acoustical properties was found. Since ancient times, shepherds of many cultures have fashioned sound instruments from the horns of herd animals for practical and musical uses. Shepherd horns of other cultures exhibit an evolution of form and technology (e.g., the inclusion of finger holes). The shofar is unique in having retained its primitive form. It is suggested that after centuries of practical use, the shofar became emblematic of the shepherd culture. Ritual use then developed, which froze its form. A modern ritual rams horn played by an experienced blower was examined. This rather short horn was determined to have a source strength of 92 dB (A) at 1 m, a fundamental frequency near 420 Hz, and maximum power output between 1.2 and 1.8 kHz. Sample sounds and detection range estimates are provided.

  14. Pregnancy in the Rudimentary Uterine Horn

    PubMed Central

    Ambusaidi, Qamariya; Jha, Chitra

    2014-01-01

    A unicornuate uterus with a rudimentary horn is a uterine anomaly resulting from the incomplete development of one of the Müllerian ducts and an incomplete fusion with the contralateral side. Pregnancy in a rudimentary horn of the uterus is a rare clinical condition with a reported incidence of 1 in 100,000 to 140,000 pregnancies. Usually the diagnosis is missed and may present as an emergency with haemoperitoneum. The standard treatment is the surgical excision of the horn. A gravida 2, para 1 patient presented at 23 weeks’ gestation with fetal demise. Repeated failed attempts at induction of labour raised the suspicion of an abnormally located pregnancy which was confirmed by magnetic resonance imaging. She underwent a laparotomy with right rudimentary horn excision. The final diagnosis of a non-communicating rudimentary horn pregnancy was made intraoperatively and was confirmed by histopathology. This case highlights the importance of an early ultrasound in detecting uterine anomalies and the need for high clinical suspicion. PMID:24516746

  15. Little Big Horn River Water Quality Project

    SciTech Connect

    Bad Bear, D.J.; Hooker, D.

    1995-10-01

    This report summarizes the accomplishments of the Water Quality Project on the Little Big horn River during the summer of 1995. The majority of the summer was spent collecting data on the Little Big Horn River, then testing the water samples for a number of different tests which was done at the Little Big Horn College in Crow Agency, Montana. The intention of this study is to preform stream quality analysis to gain an understanding of the quality of selected portion of the river, to assess any impact that the existing developments may be causing to the environment and to gather base-line data which will serve to provide information concerning the proposed development. Citizens of the reservation have expressed a concern of the quality of the water on the reservation; surface waters, ground water, and well waters.

  16. Fully Explorable Horned Particles Hiding Charge

    NASA Astrophysics Data System (ADS)

    Guendelman, Eduardo I.; Vasihoun, Mahary

    2015-01-01

    We study a gauge field subsystem which is of a special non-linear form containing a square-root of the Maxwell term and which previously has been shown to produce a QCD-like confining gauge field dynamics in flat space-time. The condition of finite energy of the system or asymptotic flatness on one side of the horned particle implies that the charged object sitting at the throat expels all the flux it produces into the other side of the horned particle, which turns out to be of a "tube-like" nature. An outside observer in the asymptotically flat universe detects, therefore, apparently neutral object. The hiding of the electric flux behind the tube-like region of a horned particle is the only possible way that a truly charged particle can still be of finite energy, in a theory that in flat space describes confinement...

  17. Monolithic Flexure Pre-Stressed Ultrasonic Horns

    NASA Technical Reports Server (NTRS)

    Sherrit, Stewart (Inventor); Bao, Xiaoqi (Inventor); Badescu, Mircea (Inventor); Bar-Cohen, Yoseph (Inventor); Allen, Phillip Grant (Inventor)

    2015-01-01

    A monolithic ultrasonic horn where the horn, backing, and pre-stress structures are combined in a single monolithic piece is disclosed. Pre-stress is applied by external flexure structures. The provision of the external flexures has numerous advantages including the elimination of the need for a pre-stress bolt. The removal of the pre-stress bolt eliminates potential internal electric discharge points in the actuator. In addition, it reduces the chances of mechanical failure in the actuator stacks that result from the free surface in the hole of conventional ring stacks. In addition, the removal of the stress bolt and the corresponding reduction in the overall number of parts reduces the overall complexity of the resulting ultrasonic horn actuator and simplifies the ease of the design, fabrication and integration of the actuator of the present invention into other structures.

  18. Monolithic Flexure Pre-Stressed Ultrasonic Horns

    NASA Technical Reports Server (NTRS)

    Sherrit, Stewart (Inventor); Bao, Xiaoqi (Inventor); Badescu, Mircea (Inventor); Bar-Cohen, Yoseph (Inventor); Allen, Phillip Grant (Inventor)

    2016-01-01

    A monolithic ultrasonic horn where the horn, backing, and pre-stress structures are combined in a single monolithic piece is disclosed. Pre-stress is applied by external flexure structures. The provision of the external flexures has numerous advantages including the elimination of the need for a pre-stress bolt. The removal of the pre-stress bolt eliminates potential internal electric discharge points in the actuator. In addition, it reduces the chances of mechanical failure in the actuator stacks that result from the free surface in the hole of conventional ring stacks. In addition, the removal of the stress bolt and the corresponding reduction in the overall number of parts reduces the overall complexity of the resulting ultrasonic horn actuator and simplifies the ease of the design, fabrication and integration of the actuator of the present invention into other structures.

  19. 76 FR 26240 - Big Horn County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-06

    ... Forest Service Big Horn County Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Big Horn County Resource Advisory Committee will meet in Greybull, Wyoming..., 2011, and will begin at 10 a.m. ADDRESSES: The meeting will be held at the Big Horn County Weed...

  20. 78 FR 33326 - Big Horn County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-04

    ... Forest Service Big Horn County Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Big Horn County Resource Advisory Committee will meet in Greybull, Wyoming... at 3:00 p.m. ADDRESSES: The meeting will be held at Big Horn County Weed and Pest Building,...

  1. 75 FR 49886 - Big Horn County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ...; ] DEPARTMENT OF AGRICULTURE Forest Service Big Horn County Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Big Horn County Resource Advisory Committee will meet in..., 2010, and will begin at 9 a.m. ADDRESSES: The meeting will be held at the Big Horn County...

  2. 76 FR 47141 - Big Horn County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-04

    ... Forest Service Big Horn County Resource Advisory Committee AGENCY: Forest Service, USDA. ] ACTION: Notice of meeting. SUMMARY: The Big Horn County Resource Advisory Committee will meet in Greybull, Wyoming..., 2011 and will begin at 3 p.m. ADDRESSES: The meeting will be held at the Big Horn County Weed and...

  3. 76 FR 7810 - Big Horn County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ... Forest Service Big Horn County Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Big Horn County Resource Advisory Committee will meet in Lovell, Wyoming..., 2011, and will begin at 10 a.m. ADDRESSES: The meeting will be held at the Big Horn Federal...

  4. 77 FR 49779 - Big Horn County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    ... Forest Service Big Horn County Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Big Horn County Resource Advisory Committee will meet in Greybull, Wyoming... 11, 2012 and will begin at 3 p.m. ADDRESSES: The meeting will be held at the Big Horn County Weed...

  5. 75 FR 71069 - Big Horn County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-22

    ... Forest Service Big Horn County Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Big Horn County Resource Advisory Committee will meet in Greybull, Wyoming... December 1, 2010, and will begin at 10 a.m. ADDRESSES: The meeting will be held at the Big Horn County...

  6. A Case of Recurrent Rudimentary Horn Ectopic Pregnancies Managed by Methotrexate Therapy and Laparoscopic Excision of the Rudimentary Horn

    PubMed Central

    Moawad, Gaby N.; Abi Khalil, Elias D.

    2016-01-01

    This report presents a case of a 31-year-old woman successfully treated medically for a noncommunicating rudimentary horn ectopic pregnancy who presented with a second, successive rudimentary horn pregnancy. Patient underwent laparoscopic excision of right rudimentary horn and right salpingectomy after failed methotrexate therapy. Given the potential for rupture and recurrence, serious efforts should be made to excise a uterine rudimentary horn. PMID:26966602

  7. A Case of Recurrent Rudimentary Horn Ectopic Pregnancies Managed by Methotrexate Therapy and Laparoscopic Excision of the Rudimentary Horn.

    PubMed

    Moawad, Gaby N; Abi Khalil, Elias D

    2016-01-01

    This report presents a case of a 31-year-old woman successfully treated medically for a noncommunicating rudimentary horn ectopic pregnancy who presented with a second, successive rudimentary horn pregnancy. Patient underwent laparoscopic excision of right rudimentary horn and right salpingectomy after failed methotrexate therapy. Given the potential for rupture and recurrence, serious efforts should be made to excise a uterine rudimentary horn. PMID:26966602

  8. 49 CFR 229.129 - Locomotive horn.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... defectives equal to an AQL of 1% or less, as set forth in 7 CFR part 43. (2) Each locomotive built before... ambient air temperature is between 32 degrees and 104 degrees Fahrenheit inclusively; relative humidity is.... The observer shall not stand between the microphone and the horn. (8) Background noise shall...

  9. 49 CFR 229.129 - Locomotive horn.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... defectives equal to an AQL of 1% or less, as set forth in 7 CFR part 43. (2) Each locomotive built before... ambient air temperature is between 32 degrees and 104 degrees Fahrenheit inclusively; relative humidity is.... The observer shall not stand between the microphone and the horn. (8) Background noise shall...

  10. 49 CFR 229.129 - Locomotive horn.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... defectives equal to an AQL of 1% or less, as set forth in 7 CFR part 43. (2) Each locomotive built before... ambient air temperature is between 32 degrees and 104 degrees Fahrenheit inclusively; relative humidity is.... The observer shall not stand between the microphone and the horn. (8) Background noise shall...

  11. Assembly of the dorsal horn somatotopic map.

    PubMed

    Brown, P B; Koerber, H R; Millecchia, R

    1997-01-01

    We hypothesize: (a) peripheral innervation densities determine map scales in dorsal horn, (b) dorsal horn cell (DHC) receptive field (RF) geometries are determined by map scales, and (c) morphologies of primary afferents (PAs) and DHCs reflect their developmental history. We suggest the following sequence: (A) PAs project in a somatotopic mediolateral sequence. (B) DHCs assemble prototype RFs by sampling presynaptic neuropil with their dendrites. (C) PAs then project to all levels where their RFs are contained within prototype RFs of DHCs. (D) A competitive mechanism produces the adult form of DHC RFs. (E) Adult distributions of PA terminals and DHC dendrites reflect this developmental history. (F) Mediolateral somatotopic gradients are determined by RF densities of axons entering at the same levels. (G) Map scales at different rostrocaudal levels are determined by somatotopic gradients. (H) Geometries of DHC RFs are determined by constant convergence and divergence of monosynaptic connections. (I) Secondary processes further modify geometries of DHC RFs. (J) Residual self-organizing capacity supports maintenance and plastic mechanisms. We adduce the following evidence: (1) agreement between monosynaptically coupled inputs and cells' excitatory low threshold mechanoreceptive fields; (2) the temporal sequence of events during penetration of the gray matter by PAs; (3)variation of PA terminal and DHC dendritic domains as a function of map scale; (4) somatotopic gradients and geometries of DHC RFs in adult dorsal horn; (5) calculations of peripheral innervation densities and dorsal horn map scales; and (6) constant divergence and convergence between PAs and DHCs. PMID:9399410

  12. The National Implications of "Cain v. Horne"

    ERIC Educational Resources Information Center

    Keller, Tim

    2009-01-01

    This commentary addresses the Arizona Supreme Court's legal reasoning in "Cain v. Horne," which struck down two voucher programs for special needs children pursuant to one of Arizona's Blaine Amendments and explains that the court both failed to apply a straightforward textual analysis and ignored the analytical framework its prior precedents had…

  13. Monolithic Flexure Pre-Stressed Ultrasonic Horns

    NASA Technical Reports Server (NTRS)

    Sherrit, Stewart; Bao, Xiaoqi; Badescu, Mircea; Bar-Cohen, Yoseph; Allen, Phillip Grant

    2011-01-01

    High-power ultrasonic actuators are generally assembled with a horn, backing, stress bolt, piezoelectric rings, and electrodes. The manufacturing process is complex, expensive, difficult, and time-consuming. The internal stress bolt needs to be insulated and presents a potential internal discharge point, which can decrease actuator life. Also, the introduction of a center hole for the bolt causes many failures, reducing the throughput of the manufactured actuators. A new design has been developed for producing ultrasonic horn actuators. This design consists of using flexures rather than stress bolts, allowing one to apply pre-load to the piezoelectric material. It also allows one to manufacture them from a single material/plate, rapid prototype them, or make an array in a plate or 3D structure. The actuator is easily assembled, and application of pre-stress greater than 25 MPa was demonstrated. The horn consists of external flexures that eliminate the need for the conventional stress bolt internal to the piezoelectric, and reduces the related complexity. The stress bolts are required in existing horns to provide prestress on piezoelectric stacks when driven at high power levels. In addition, the manufacturing process benefits from the amenability to produce horn structures with internal cavities. The removal of the pre-stress bolt removes a potential internal electric discharge point in the actuator. In addition, it significantly reduces the chances of mechanical failure in the piezoelectric stacks that result from the hole surface in conventional piezoelectric actuators. The novel features of this disclosure are: 1. A design that can be manufactured from a single piece of metal using EDM, precision machining, or rapid prototyping. 2. Increased electromechanical coupling of the horn actuator. 3. Higher energy density. 4. A monolithic structure of a horn that consists of an external flexure or flexures that can be used to pre-stress a solid piezoelectric structure

  14. Penile cutaneous horn: An enigma-newer insights and perspectives.

    PubMed

    Karthikeyan, Kaliaperumal

    2015-01-01

    Cutaneous horn refers to unusually cohesive keratinized material and not a true pathologic diagnosis. Though cutaneous horn has been described at various sites, horn over the penis is very rare and represents the most unusual site. The role of chronic irritation, phimosis, surgical trauma and radiotherapy have been implicated in penile horn formation. Penile horns present as elongated, keratinous, white or yellowish projections that range from a few millimeters to centimeters in size arising from the glans penis. Histopathology of the keratotic mass reveals nothing but keratin. The underlying mass may vary from verruca vulgaris to squamous cell carcinoma. The treatment is based on the pathology. PMID:26392650

  15. Measuring cooperative Rev protein-protein interactions on Rev responsive RNA by fluorescence resonance energy transfer

    PubMed Central

    Vercruysse, Thomas; Pawar, Sonalika; De Borggraeve, Wim; Pardon, Els; Pavlakis, George N; Pannecouque, Christophe; Steyaert, Jan; Balzarini, Jan

    2011-01-01

    The export of viral RNA from the nucleus to the cytoplasm of the cellular host is a crucial step in the life cycle of HIV-1 that is mediated by the viral Rev protein. One aspect of the Rev function, its multimerization, is still unexplored as a target for antiviral therapy. This is partly due to the lack of a fast and solid system to measure Rev multimerization. We have developed a high throughput in vitro Rev multimerization assay based on fluorescence resonance energy transfer (FRET) in which real-time Rev-Rev interactions can be measured both in the absence and the presence of Rev specific RRE RNA. Well-characterized Rev multimerization deficient mutants showed reduced FRET as well as unlabeled Rev molecules were able to inhibit the FRET signal demonstrating the specificity of the assay. Upon multimerization along RRE RNA the FRET signal significantly increased but dropped again at equimolar Rev/RRE ratios suggesting that in this condition most Rev molecules are bound as monomers to the RRE. Furthermore, using this assay, we demonstrate that a previously selected llama heavy-chain only antibody was shown to not only prevent the development of Rev multimers but also disassemble the already formed complexes confirming the dynamic nature of the Rev-Rev interactions. The in vitro FRET based multimerization assay facilitates the further study of the basic mechanism of cooperative Rev multimerization along the RRE and is also widely applicable to study the assembly of other functional complexes involving protein homo-multimerization or cooperative protein-protein interactions on RNA or DNA. PMID:21358282

  16. Mechanical and biological properties of oxidized horn keratin.

    PubMed

    Zhang, Quanbin; Shan, Guanghua; Cao, Ping; He, Jia; Lin, Zhongshi; Huang, Yaoxiong; Ao, Ningjian

    2015-02-01

    The goal of this study was to investigate the mechanical and biological properties of oxidized keratin materials, which were obtained by using buffalo horns to oxidize. It could provide a way to evaluate their potential for clinical translatability. The characterization on their composition, mechanical properties, and biological responses was performed. It is found that the oxidation process could lead the disulfide bond to break down and then to form sulfonic acid, or even make partial peptide chain to be fragment for the new modification of amino acid. Hence the oxidized horn keratins have lower thermal stability and hydrolytic stability in comparison with horn keratin, but the degradation products of oxidized horn keratins have no significant difference. In addition, the mechanical properties of oxidized horn keratins are poorer than that of horn keratin, but the oxidized horn keratins still have disulfide bonds to form a three-dimensional structure, which benefits for their mechanical properties. The fracture toughness of oxidized horn keratins increases with the increase in the degree of oxidation. After oxidation, the oxidized horn keratins have lower cytotoxicity and lower hemolysis ratio. Moreover, when the oxidized horn keratins, as well as different concentration of degradation products of oxidized horn keratins, are directly in contact with platelet-rich plasma, platelets are not activated. It suggests that the oxidized horn keratins have good hemocompatibility, without triggering blood thrombosis. The implantation experiment in vivo also demonstrates that the oxidized horn keratins are compatible with the tissue, because there are minimal fibrous capsule and less of infiltration of host cells, without causing serious inflammation. In summary, the oxidized horn keratins can act as implanted biomaterial devices that are directly in contact with blood and tissue. PMID:25492180

  17. Applications for concrete offshore

    SciTech Connect

    Not Available

    1982-01-01

    The report collects and summarizes the various proposals for development offshore which have in common the use of concrete as the main structural material, and where possible, indicates their relative feasibility. A study encompassing such diverse schemes as offshore windmills, concrete LNG carriers, hydrocarbon production platforms and floating airports cannot be completely exhaustive on each subject, so references to sources of further information have been given wherever possible. Details of individual projects and proposals are included for Power plants, Hydrocarbon production platforms, Concrete ships, Storage systems and industrial plants, Subsea systems, Offshore islands, Coastal works and Other concrete structures.

  18. Dual band combiner for horn antenna

    NASA Technical Reports Server (NTRS)

    Williams, W. F.; Cohn, S. B. (Inventor)

    1980-01-01

    A corrugated horn antenna, adapted to be coupled to a waveguide at its apex for X-band excitation is further adapted to be connected to waveguides through a circumferential slot for S-band excitation at four distinct phases selected for the desired S-band polarization. The circumferential slot is positioned along the axial length of the horn for good impedance matching and is provided with an X-band choke in the form of two concentric choke slots. For further improvement in impedance matching, the second (outer) choke slot is divided by plugs into four segments that coincide with waveguide ports for the four distinct phases of the S-band.

  19. The effect of nearby timpani strokes on horn playing.

    PubMed

    Chen, Jer-Ming; Smith, John; Wolfe, Joe

    2014-01-01

    Horn players have observed that timpani strokes can interfere disruptively with their playing, especially when they are seated close to the timpani. Measuring the horn's transfer function in the bell-to-mouthpiece direction reveals that the horn behaves as an acoustic impedance matching device, capable of transmitting waves with pressure gains of at least 20 dB near horn playing resonances. During moderate to loud timpani strokes, the horn transmits an overall impulse gain response of at least 16 dB from the bell to the mouthpiece, while evidence of non-linear bore propagation can be observed for louder strokes. If the timpani is tuned near a horn resonance, as is usually the case, further bore resonance interactions may be observed leading to gains of ∼26 dB from bell to mouthpiece. Finally, measurements of horn playing made under conditions approximating playing reveal that timpani strokes sounding near the horn bell are capable of disrupting horn playing by affecting the amplitude, periodicity, and frequency of the pressure signal generated at the horn player's lips. PMID:24437787

  20. Optimized Chemical Probes for REV-ERBα

    PubMed Central

    Trump, Ryan P.; Bresciani, Stefano; Cooper, Anthony W. J.; Tellam, James P.; Wojno, Justyna; Blaikley, John; Orband-Miller, Lisa A.; Kashatus, Jennifer A.; Dawson, Helen C.; Loudon, Andrew; Ray, David; Grant, Daniel; Farrow, Stuart N.; Willson, Timothy M.; Tomkinson, Nicholas C. O.

    2015-01-01

    REV-ERBα has emerged as an important target for regulation of circadian rhythm and its associated physiology. Herein, we report on the optimization of a series of REV-ERBα agonists based on GSK4112 (1) for potency, selectivity, and bioavailability. Potent REV-ERBα agonists 4, 10, 16, and 23 are detailed for their ability to suppress BMAL and IL-6 expression from human cells while also demonstrating excellent selectivity over LXRα. Amine 4 demonstrated in vivo bioavailability after either IV or oral dosing. PMID:23656296

  1. Great horned owls are released at CCAFS

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Susan Small, director of the Florida Wildlife Hospital, holds a great horned owl before releasing it at Cape Canaveral Air Force Station, Complex 25/29. The owl is one of two found in June on the floor of CCAFS Hangar G, where their nest was located. They were treated at a local veterinary hospital and then taken to the Florida Wildlife Hospital in Melbourne for care and rehabilitation before release.

  2. Great horned owls are released at CCAFS

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Eileen Olejarski (left), manager of Florida Wildlife Hospital, and Susan Small, director of the hospital, remove two great horned owls from the vehicle before releasing them at Cape Canaveral Air Force Station, Complex 25/29. The owls were found in June on the floor of CCAFS Hangar G, where their nest was located. They were treated at a local veterinary hospital and then taken to the Florida Wildlife Hospital in Melbourne for care and rehabilitation before release..

  3. Great horned owls are released at CCAFS

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Eileen Olejarski (left), manager of Florida Wildlife Hospital, and Susan Small, director of the hospital, get ready to release two great horned owls at Cape Canaveral Air Force Station, Complex 25/29. The owls were found in June on the floor of CCAFS Hangar G, where their nest was located. They were treated at a local veterinary hospital and then taken to the Florida Wildlife Hospital in Melbourne for care and rehabilitation before release.

  4. Great horned owls are released at CCAFS

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Eileen Olejarski (left), manager of Florida Wildlife Hospital, holds a great horned owl before releasing it at Cape Canaveral Air Force Station, Complex 25/29. The owl is one of two found in June on the floor of CCAFS Hangar G, where their nest was located. They were treated at a local veterinary hospital and then taken to the Florida Wildlife Hospital in Melbourne for care and rehabilitation before release.

  5. Great horned owls are released at CCAFS

    NASA Technical Reports Server (NTRS)

    2000-01-01

    A great horned owl flies to freedom after its release at Cape Canaveral Air Force Station, Complex 25/29. The owl is one of two found in June on the floor of CCAFS Hangar G, where their nest was located. They were treated at a local veterinary hospital and then taken to the Florida Wildlife Hospital in Melbourne for care and rehabilitation before release.

  6. Analog of the Clauser-Horne-Shimony-Holt inequality for steering

    NASA Astrophysics Data System (ADS)

    Cavalcanti, Eric G.; Foster, Christopher J.; Fuwa, Maria; Wiseman, Howard M.

    2015-04-01

    The Clauser-Horne-Shimony-Holt (CHSH) inequality (and its permutations), are necessary and sufficient criteria for Bell nonlocality in the simplest Bell-nonlocality scenario: 2 parties, 2 measurements per party and 2 outcomes per measurement. Here we derive an inequality for EPR-steering that is an analogue of the CHSH, in that it is necessary and sufficient in this same scenario. However, since in the case of steering the device at Bob's site must be specified (as opposed to the Bell case in which it is a black box), the scenario we consider is that where Alice performs two (black-box) dichotomic measurements, and Bob performs two mutually unbiased qubit measurements. We show that this inequality is strictly weaker than the CHSH, as expected, and use it to decide whether a recent experiment [Phys. Rev. Lett. 110, 130401 (2013).] involving a single-photon split between two parties has demonstrated EPR-steering.

  7. Measurement-induced nonlocality in the W and Greenberger-Horne-Zeilinger superposition states

    NASA Astrophysics Data System (ADS)

    Lin, Qin; Bai, Yan-Kui; Ye, Ming-Yong; Lin, Xiu-Min

    2015-03-01

    Measurement-induced nonlocality (MIN) is a newly defined quantity to measure correlations in bipartite quantum states [Luo S and Fu S 2011 Phys. Rev. Lett. 106 120401]. MIN in the n-qubit W and Greenberger-Horne-Zeilinger (GHZ) superposition states is considered. It is revealed that n=3 and n ≥ 4 states have very different characteristics, especially the monogamy relation about MIN, and the monogamy equality of MIN is held in all n-qubit W states (n ≥ 3). Project supported by the National Natural Science Foundation of China (Grant Nos. 61275215 and 10905016), the National Fundamental Research Program of China (Grant No. 2011CBA00203), the Fujian Provincial College Funds for Distinguished Young Scientists, China (Grant No. JA14070), and the Natural Science Foundation of Hebei Province, China (Grant No. A2012205062).

  8. Aperture efficiency of integrated-circuit horn antennas

    NASA Technical Reports Server (NTRS)

    Guo, Yong; Lee, Karen; Stimson, Philip; Potter, Kent; Rutledge, David

    1991-01-01

    The aperture efficiency of silicon integrated-circuit horn antennas has been improved by optimizing the length of the dipole probes and by coating the entire horn walls with gold. To make these measurements, a new thin-film power-density meter was developed for measuring power density with accuracies better than 5 percent. The measured aperture efficiency improved from 44 percent to 72 percent at 93 GHz. This is sufficient for use in many applications which now use machined waveguide horns.

  9. The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly.

    PubMed

    DiMattia, Michael A; Watts, Norman R; Cheng, Naiqian; Huang, Rick; Heymann, J Bernard; Grimes, Jonathan M; Wingfield, Paul T; Stuart, David I; Steven, Alasdair C

    2016-07-01

    HIV-1 Rev protein mediates the nuclear export of viral RNA genomes. To do so, Rev oligomerizes cooperatively onto an RNA motif, the Rev response element (RRE), forming a complex that engages with the host nuclear export machinery. To better understand Rev oligomerization, we determined four crystal structures of Rev N-terminal domain dimers, which show that they can pivot about their dyad axis, giving crossing angles of 90° to 140°. In parallel, we performed cryoelectron microscopy of helical Rev filaments. Filaments vary from 11 to 15 nm in width, reflecting variations in dimer crossing angle. These structures contain additional density, indicating that C-terminal domains become partially ordered in the context of filaments. This conformational variability may be exploited in the assembly of RRE/Rev complexes. Our data also revealed a third interface between Revs, which offers an explanation for how the arrangement of Rev subunits adapts to the "A"-shaped architecture of the RRE in export-active complexes. PMID:27265851

  10. Beyond "Cain v. Horne": Comment on Tim Keller's "The National Implications of 'Cain v. Horne'"

    ERIC Educational Resources Information Center

    Harmon, Corinne

    2010-01-01

    This commentary is in response to Tim Keller's article "The National Implications of 'Cain v. Horne.'" In his analysis, Keller asserts that the Arizona Supreme Court wrongfully struck down a voucher program for students with special needs by characterizing the voucher as aid to schools rather than aid to students. In this response to Keller, I…

  11. CONCEPTUAL DESIGN STUDY OF HORN POWER SUPPLY.

    SciTech Connect

    ZHANG,W.; SANDBERG,J.; WENG,W.T.

    2003-06-16

    A 250 kA pulsed power supply is required for the focusing horn of the proposed Brookhaven AGS Super Neutrino Beam Facility for long baseline neutrino oscillation experiment. It is expected to pulse at 2.5 Hz repetition rate. A preliminary study is being conducted to explore the key issues associated with the power supply system design. Advanced technologies used in similar systems as well as new ideas are being examined, simulated and evaluated. This power supply will be a very high stored energy, high average power, and high peak power system.

  12. Experimental rabies in a great horned owl.

    PubMed

    Jorgenson, R D; Gough, P M; Graham, D L

    1976-07-01

    A great horned owl (Bubo virginianus) was fed the carcass of an experimentally infected rabid skunk. The bird developed antibody titer to rabies, detected by passive haemagglutination, 27 days after oral inoculation by ingestion. The owl suppressed the infection until corticosteroid administration, after which a maximum antibody titer was attained. Evidence of active rabies viral infection was seen by fluorescent antibody staining of oral swabs, corneal impression smears and histologic tissue smears, by suckling mouse inoculation of oral swab washings, and by transmission electron microcopy. No clinical signs of rabies virus infection were observed. PMID:16498892

  13. Drilling and producing offshore

    SciTech Connect

    Hall, R.S.

    1983-01-01

    Hall and his team of authors share technically detailed state-of-the-art designs, equipment and techniques, focusing on fixed-platform operations. This book provides explicit data on offshore equipment and procedures. Contents: Development drilling structures -- template, concrete gravity, and other platforms; Development drilling systems -- through-the-leg drilling, floating drilling, tension-leg platform drilling, template utilization, and mud-line casing suspension and casing support systems; Completion systems -- platform completions, through-the-leg completions, tension-leg completions, multiwell subsea completions, and subsea satellite completion systems; Production control -- wellhead control systems and subsea production control systems; Offshore oil-field diving operations and equipment -- commercial diving, history of diving, international offshore oil-field diving, physiological constraints in diving, diving capabilities and equipment, future trends.

  14. Energy from Offshore Wind: Preprint

    SciTech Connect

    Musial, W.; Butterfield, S.; Ram, B.

    2006-02-01

    This paper provides an overview of the nascent offshore wind energy industry including a status of the commercial offshore industry and the technologies that will be needed for full market development.

  15. Offshore rectenna feasbility

    NASA Technical Reports Server (NTRS)

    Freeman, J. W.; Hervey, D.; Glaser, P.

    1980-01-01

    A preliminary study of the feasibility and cost of an offshore rectenna to serve the upper metropolitan east coast was performed. A candidate site at which to build a 5 GW rectenna was selected on the basis of proximity to load centers, avoidance of shipping lanes, sea floor terrain, and relocated conditions. Several types of support structures were selected for study based initially on the reference system rectenna concept of a wire mesh ground screen and dipoles each with its own rectifier and filter circuits. Possible secondary uses of an offshore rectenna were examined and are evaluated.

  16. Offshore wave energy experiment

    SciTech Connect

    Nielsen, K.; Scholten, N.C.; Soerensen, K.A. |

    1995-12-31

    This article describes the second phase of the off-shore wave energy experiment, taking place in the Danish part of the North Sea near Hanstholm. The wave power converter is a scale model consisting of a float 2.5 meter in diameter connected by rope to a seabed mounted piston pump installed on 25 meter deep water 2,5 km offshore. The structure, installation procedure results and experience gained during the test period will be presented and compared to calculations based on a computer model.

  17. Bioprospecting for podophyllotoxin in the Big Horn Mountains, Wyoming

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The objective of this study was to evaluate variations in podophyllotoxin concentrations in Juniperus species found in the Big Horn Mountains in Wyoming. It was found that Juniperus species in the Big Horn Mountains included three species; J. communis L. (common juniper), J. horizontalis Moench. (c...

  18. Rudimentary horn pregnancy: pre-rupture diagnosis and management.

    PubMed

    Buntugu, Ka; Ntumy, My; Ameh, Eo; Obed, Sa

    2008-06-01

    Rudimentary horn pregnancy is a rare obstetric entity and the diagnosis and management may pose some problems especially in a low-resource center. We report our experience in diagnosing and managing a case of fetal death in a rudimentary horn. PMID:19180211

  19. Planar Rotary Motor Using Ultrasonic Horns

    NASA Technical Reports Server (NTRS)

    Sherrit, Stewart; Bao, Xiaoqi; Badescu, Mircea; Chang, Zensheu; Geiyer, Daniel; Allen, Phillip; Ostlund, Patrick; Bar-Cohen, Yoseph

    2011-01-01

    One of the first piezoelectric motor designs with significant rotational speeds was outlined by Barth. This device used extensional piezoelectric elements to produce a time varying force at a distance r from the center of a centrally supported disk. These extensional actuators produced micro-steps at a high frequency with the end result being macroscopic rotation of the disk and high torque. The rotation direction is controlled by the choice of the actuators and the direction of the extension about the rotor center. A recent advancement in producing pre-stressed power ultrasonic horns using flexures allows for the development of high torque ultrasonic motors based on the Barth's idea that can be fabricated in a 2D plate or in more complicated 3D structures. In addition to the pre-stress flexures the design also allows for the use of flexures to produce the rotor/horn normal force. The torque can be controlled by the number of actuators in the plane and the amplitude of the normal force. This paper will present analytical and experimental results obtained from testing prototype planar motors.

  20. Diagnostic findings in 132 great horned owls

    USGS Publications Warehouse

    Franson, J.C.; Little, S.E.

    1996-01-01

    We reviewed diagnostic findings for 132 great horned owl (Bubo virginianus) carcasses that were submitted to the National Wildlife Health Center from 1975-93. The carcasses were collected in 24 states but most came from Colorado (N = 21), Missouri (N = 12), Oregon (N = 12), Wyoming (N = 11), Illinois (N = 10), and Wisconsin (N = 9). Forty-two birds were emaciated but presumptive causes of emaciation, including old injuries, chronic lesions in various organs, and exposure to dieldrin, were found in only 16. A greater proportion of juveniles (56%) than adults (29%) were emaciated. Twelve owls were shot and 35 died from other traumatic injuries. Poisonings were diagnosed in 11 birds, including five associated with hydrogen sulfide exposure in oil fields and six cases of agricultural pesticide poisonings. Electrocution killed nine birds and infectious diseases were found in six. Miscellaneous conditions, including egg impaction, drowning, and visceral gout were diagnosed in three of the birds and the cause of death was undetermined in 14 owls. While this review identifies major diagnostic findings in great horned owls, sample bias prevents definitive conclusions regarding actual proportional causes of mortality.

  1. Progress Toward Corrugated Feed Horn Arrays in Silicon

    SciTech Connect

    Britton, J.; Yoon, K. W.; Beall, J. A.; Becker, D.; Cho, H. M.; Hilton, G. C.; Niemack, M. D.; Irwin, K. D.

    2009-12-16

    We are developing monolithic arrays of corrugated feed horns fabricated in silicon for dual-polarization single-mode operation at 90, 145 and 220 GHz. The arrays consist of hundreds of platelet feed horns assembled from gold-coated stacks of micro-machined silicon wafers. As a first step, Au-coated Si waveguides with a circular, corrugated cross section were fabricated; their attenuation was measured to be less than 0.15 dB/cm from 80 to 110 GHz at room temperature. To ease the manufacture of horn arrays, electrolytic deposition of Au on degenerate Si without a metal seed layer was demonstrated. An apparatus for measuring the radiation pattern, optical efficiency, and spectral band-pass of prototype horns is described. Feed horn arrays made of silicon may find use in measurements of the polarization anisotropy of the cosmic microwave background radiation.

  2. [Rudimentary horn pregnancy: first trimester ultrasound diagnosis and laparoscopic confirmation].

    PubMed

    Salazar-López, R; Antillón-Valenzuela, J

    2013-08-01

    Case report of rudimentary uterine horn on first trimester pregnancy that was diagnosed by sonographic images and laparoscopically confirmed. We suggest a set of criteria for early diagnosis of this rare condition using sonographic with 3D endovaginal ultrasound. We present a first trimester extrauterine pregnancy that was diagnosed in rutinary sonographic analisys. A rudimentary horn pregnancy was detected by sonographic with 3D endovaginal ultrasound, that was confirmed laparoscopically. Rudimentary horn pregnancy was right sided without endometrial communication with the uterine body. The rudimentary horn pregnancy was laparoscopically resected, a fibrous bridge between horn and uterus is confirmed, also a normal aspect tube was observed, wich was underwent to fimbriectomy. We suggest to consider this rare posibility on extrauterine pregnancy diagnosis, and also apply 3D technology under endovaginal route to achieve an early diagnosis and avoid rupture. PMID:24049979

  3. Functional genomics of the horn fly, Haematobia irritans (Linnaeus, 1758)

    PubMed Central

    2011-01-01

    Background The horn fly, Haematobia irritans (Linnaeus, 1758) (Diptera: Muscidae) is one of the most important ectoparasites of pastured cattle. Horn flies infestations reduce cattle weight gain and milk production. Additionally, horn flies are mechanical vectors of different pathogens that cause disease in cattle. The aim of this study was to conduct a functional genomics study in female horn flies using Expressed Sequence Tags (EST) analysis and RNA interference (RNAi). Results A cDNA library was made from whole abdominal tissues collected from partially fed adult female horn flies. High quality horn fly ESTs (2,160) were sequenced and assembled into 992 unigenes (178 contigs and 814 singlets) representing molecular functions such as serine proteases, cell metabolism, mitochondrial function, transcription and translation, transport, chromatin structure, vitellogenesis, cytoskeleton, DNA replication, cell response to stress and infection, cell proliferation and cell-cell interactions, intracellular trafficking and secretion, and development. Functional analyses were conducted using RNAi for the first time in horn flies. Gene knockdown by RNAi resulted in higher horn fly mortality (protease inhibitor functional group), reduced oviposition (vitellogenin, ferritin and vATPase groups) or both (immune response and 5'-NUC groups) when compared to controls. Silencing of ubiquitination ESTs did not affect horn fly mortality and ovisposition while gene knockdown in the ferritin and vATPse functional groups reduced mortality when compared to controls. Conclusions These results advanced the molecular characterization of this important ectoparasite and suggested candidate protective antigens for the development of vaccines for the control of horn fly infestations. PMID:21310032

  4. Offshore Wind Energy Systems

    ERIC Educational Resources Information Center

    Musgrove, P.

    1978-01-01

    Explores the possibility of installing offshore windmills to provide electricity and to save fuel for the United Kingdom. Favors their deployment in clusters to facilitate supervision and minimize cost. Discusses the power output and the cost involved and urges their quick development. (GA)

  5. A nonrational B-spline profiled horn with high displacement amplification for ultrasonic welding.

    PubMed

    Nguyen, Huu-Tu; Nguyen, Hai-Dang; Uan, Jun-Yen; Wang, Dung-An

    2014-12-01

    A new horn with high displacement amplification for ultrasonic welding is developed. The profile of the horn is a nonrational B-spline curve with an open uniform knot vector. The ultrasonic actuation of the horn exploits the first longitudinal displacement mode of the horn. The horn is designed by an optimization scheme and finite element analyses. Performances of the proposed horn have been evaluated by experiments. The displacement amplification of the proposed horn is 41.4% and 8.6% higher than that of the traditional catenoidal horn and a Bézier-profile horn, respectively, with the same length and end surface diameters. The developed horn has a lower displacement amplification than the nonuniform rational B-spline profiled horn but a much smoother stress distribution. The developed horn, the catenoidal horn, and the Bézier horn are fabricated and used for ultrasonic welding of lap-shear specimens. The bonding strength of the joints welded by the open uniform nonrational B-spline (OUNBS) horn is the highest among the three horns for the various welding parameters considered. The locations of the failure mode and the distribution of the voids of the specimens are investigated to explain the reason of the high bonding strength achieved by the OUNBS horn. PMID:25081407

  6. Offshore Wind Research (Fact Sheet)

    SciTech Connect

    Not Available

    2011-10-01

    This 2-page fact sheet describes NREL's offshore wind research and development efforts and capabilities. The National Renewable Energy Laboratory is internationally recognized for offshore wind energy research and development (R&D). Its experience and capabilities cover a wide spectrum of wind energy disciplines. NREL's offshore wind R&D efforts focus on critical areas that address the long-term needs of the offshore wind energy industry and the Department of Energy (DOE). R&D efforts include: (1) Developing offshore design tools and methods; (2) Collaborating with international partners; (3) Testing offshore systems and developing standards; (4) Conducting economic analyses; (5) Characterizing offshore wind resources; and (6) Identifying and mitigating offshore wind grid integration challenges and barriers. NREL has developed and maintains a robust, open-source, modular computer-aided engineering (CAE) tool, known as FAST. FAST's state-of-the-art capabilities provide full dynamic system simulation for a range of offshore wind systems. It models the coupled aerodynamic, hydrodynamic, control system, and structural response of offshore wind systems to support the development of innovative wind technologies that are reliable and cost effective. FAST also provides dynamic models of wind turbines on offshore fixed-bottom systems for shallow and transitional depths and floating-platform systems in deep water, thus enabling design innovation and risk reduction and facilitating higher performance designs that will meet DOE's cost of energy, reliability, and deployment objectives.

  7. The Bovine Immunodeficiency Virus Rev Protein: Identification of a Novel Nuclear Import Pathway and Nuclear Export Signal among Retroviral Rev/Rev-Like Proteins

    PubMed Central

    Gomez Corredor, Andrea

    2012-01-01

    The Rev protein is essential for the replication of lentiviruses. Rev is a shuttling protein that transports unspliced and partially spliced lentiviral RNAs from the nucleus to the cytoplasm via the nucleopore. To transport these RNAs, the human immunodeficiency virus type 1 (HIV-1) Rev uses the karyopherin β family importin β and CRM1 proteins that interact with the Rev nuclear localization signal (NLS) and nuclear exportation signal (NES), respectively. Recently, we reported the presence of new types of bipartite NLS and nucleolar localization signal (NoLS) in the bovine immunodeficiency virus (BIV) Rev protein. Here we report the characterization of the nuclear import and export pathways of BIV Rev. By using an in vitro nuclear import assay, we showed that BIV Rev is transported into the nucleus by a cytosolic and energy-dependent importin α/β classical pathway. Results from glutathione S-transferase (GST) pulldown assays that showed the binding of BIV Rev with importins α3 and α5 were in agreement with those from the nuclear import assay. We also identified a leptomycin B-sensitive NES in BIV Rev, which indicates that the protein is exported via CRM1 like HIV-1 Rev. Mutagenesis experiments showed that the BIV Rev NES maps between amino acids 109 to 121 of the protein. Remarkably, the BIV Rev NES was found to be of the cyclic AMP (cAMP)-dependent protein kinase inhibitor (PKI) type instead of the HIV-1 Rev type. In summary, our data showed that the nuclear import mechanism of BIV Rev is novel among Rev proteins characterized so far in lentiviruses. PMID:22379104

  8. Offshore space center (offshore launch site)

    SciTech Connect

    Harvey, D.G.

    1980-07-01

    Any activity requiring the development of the HLLV can benefit by operations from an offshore space center (OSC) since operating near the equator provides a twenty percent increase in payload in an ecliptic plan orbit. Some OSC concepts considered include a moored floating (semisubmersible) design, a stationary design supported by fixed piles, and a combination of these two. The facility supports: a 15,000 foot long, 300 foot wide runway, designed to accommodate a two staged winged launch vehicle, with a one million pound payload capacity to low earth orbit, an industrial area for HLLV maintenance, an airport terminal, control and operation center, and observation tower, liquid hydrogen and liquid oxygen production and storage, and fuel storage platforms, a power generation station, docks with an unloading area, two separate launch sites, and living accommodations for 10,000 people. Potential sites include the Paramount Seamount in the Pacific Ocean off the north coast of South America. Cost estimates are considered.

  9. Offshore Space Center (offshore launch site)

    NASA Technical Reports Server (NTRS)

    Harvey, D. G.

    1980-01-01

    Any activity requiring the development of the HLLV can benefit by operations from an offshore space center (OSC) since operating near the equator provides a twenty percent increase in payload in an ecliptic plan orbit. Some OSC concepts considered include a moored floating (semisubmersible) design, a stationary design supported by fixed piles, and a combination of these two. The facility supports: a 15,000 foot long, 300 foot wide runway, designed to accommodate a two staged winged launch vehicle, with a one million pound payload capacity to low earth orbit; an industrial area for HLLV maintenance; an airport terminal, control and operation center, and observation tower; liquid hydrogen and liquid oxygen production and storage, and fuel storage platforms; a power generation station, docks with an unloading area; two separate launch sites; and living accommodations for 10,000 people. Potential sites include the Paramount Seamount in the Pacific Ocean off the north coast of South America. Cost estimates are considered.

  10. 49 CFR 222.59 - When may a wayside horn be used?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... grade crossing equipped with a wayside horn shall not be considered in calculating the Quiet Zone Risk Index or Crossing Corridor Risk Index. (b) A public authority installing a wayside horn at a grade... wayside horn will be operational and identify the grade crossing at which the wayside horn shall...

  11. A 20-dB quasi-integrated horn antenna

    NASA Technical Reports Server (NTRS)

    Eleftheriades, George V.; Ali-Ahmad, Walid Y.; Rebeiz, Gabriel M.

    1992-01-01

    A multimode quasi-integrated dipole-fed horn antenna is presented with a performance comparable to that of waveguide-fed corrugated horn antennas. The antenna has been designed using fullwave analysis and has been fabricated and tested at 91 GHz. The horn has a gain of 20 dB with very symmetric patterns, a Gaussian coupling efficiency of 97 percent, and a cross-polarization level of -22.7 dB. The antenna provides a significant improvement in integrated antenna designs and is suitable for millimeter-wave communication and radar systems and as a Gaussian-beam launcher in quasi-optical receiver systems.

  12. Formal verification of communication protocols using quantized Horn clauses

    NASA Astrophysics Data System (ADS)

    Balu, Radhakrishnan

    2016-05-01

    The stochastic nature of quantum communication protocols naturally lends itself for expression via probabilistic logic languages. In this work we describe quantized computation using Horn clauses and base the semantics on quantum probability. Turing computable Horn clauses are very convenient to work with and the formalism can be extended to general form of first order languages. Towards this end we build a Hilbert space of H-interpretations and a corresponding non commutative von Neumann algebra of bounded linear operators. We demonstrate the expressive power of the language by casting quantum communication protocols as Horn clauses.

  13. Understanding recent eastern Horn of Africa rainfall variability and change

    USGS Publications Warehouse

    Liebmann, Brant; Hoerling, Martin P.; Funk, Christopher C.; Blade, Ileana; Dole, Randall M.; Allured, Dave; Quan, Xiaowei; Eischeid, Jon K.

    2014-01-01

    The recent upward trend in the October–December wet season is rather weak, however, and its statistical significance is compromised by strong year-to-year fluctuations. October–December eastern Horn rain variability is strongly associated with El Niño–Southern Oscillation and Indian Ocean dipole phenomena on interannual scales, in both model and observations. The interannual October–December correlation between the ensemble-average and observed Horn rainfall 0.87. By comparison, interannual March–May Horn precipitation is only weakly constrained by SST anomalies.

  14. Arctic offshore platform

    SciTech Connect

    Bhula, D.N.

    1984-01-24

    An offshore structure is disclosed for use in drilling and producing wells in arctic regions having a conical shaped lower portion that extends above the surface of the water and a cylindrical upper section. The conical portion is provided with a controlled stiffness outer surface for withstanding the loads produced by ice striking the structure. The stiffness properties of the outer shell and flexible members are designed to distribute the load and avoid high local loads on the inner parts of the structure.

  15. Design of a Bézier-profile horn for high displacement amplification.

    PubMed

    Wang, D-A; Chuang, W-Y; Hsu, K; Pham, H-T

    2011-02-01

    A new horn for high displacement amplification is developed. The profile of the horn is a cubic Bézier curve. The ultrasonic actuation of the horn exploits the first longitudinal displacement mode of the horn. A design method of the horn using an optimization scheme and finite element analyses is developed. Prototypes of the horns are manufactured by a numerical control machining process. Performances of the proposed horn have been evaluated by experiments. Experimental results of the harmonic response of the fabricated horn confirm the effectiveness of the design method. The displacement amplification of the proposed horn is 71% higher than that of the traditional catenoidal horn with the same length and end surface diameters. PMID:20696449

  16. Image measurement technique on vibration amplitude of ultrasonic horn

    NASA Astrophysics Data System (ADS)

    Zhang, Yong-bin; Wu, Zhi-qun; Zhu, Jian-ping; He, Jian-guo; Liu, Guang-min

    2013-10-01

    The paper proposes a method to measure vibration amplitude of ultrasonic horn which is a very important component in the spindle for micro-electrical-chemical discharging machining. The method of image measuring amplitude on high frequency vibration is introduced. Non-contact measurement system based on vision technology is constructed. High precision location algorithm on image centroid, quadratic location algorithm, is presented to find the center of little light spot. Measurement experiments have been done to show the effect of image measurement technique on vibration amplitude of ultrasonic horn. In the experiments, precise calibration of the vision system is implemented using a normal graticule to obtain the scale factor between image pixel and real distance. The vibration amplitude of ultrasonic horn is changed by modifying the voltage amplitude of pulse power supply. The image of feature on ultrasonic horn is captured and image processing is carried out. The vibration amplitudes are got at different voltages.

  17. 28. Photograph of interior view of fog horn signal building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. Photograph of interior view of fog horn signal building with two lighthouse keepers by steam engine wheel, ca. 1920. - Block Island Southeast Light, Spring Street & Mohegan Trail at Mohegan Bluffs, New Shoreham, Washington County, RI

  18. An aperture-matched compact range feed horn design

    NASA Technical Reports Server (NTRS)

    Heedy, D. J.; Burnside, W. D.

    1985-01-01

    The moment method and the uniform geometrical theory of diffraction are used to obtain two separate solutions for the E-plane far field pattern of an aperture-matched horn antenna. This particular horn antenna consists of a standard pyramidal horn with the following modifications: a rolled edge section attached to the aperture edges and a curved throat section. The resulting geometry provides significantly better performance in terms of the pattern, impedance, and frequency characteristics than normally obtainable. The moment method is used to calculate the E-plane pattern and voltage standing-wave ratio (VSWR) of the antenna. However, at higher frequencies, the moment method requires large amounts of computation time. On the other hand, the uniform geometrical theory of diffraction provides a quick and efficient high frequency solution for the E-plane field pattern. This procedure has been successfully applied to design a compact range feed horn.

  19. The limits on combining recursive horn rules with description logics

    SciTech Connect

    Levy, A.Y.; Rousset, M.C.

    1996-12-31

    Horn rule languages have formed the basis for many Artificial Intelligence application languages, but are not expressive enough to model domains with a rich hierarchical structure. Description logics have been designed especially to model rich hierarchies. Several applications would significantly benefit from combining the expressive power of both formalisms. This paper focuses on combining recursive function-free Horn rules with the expressive description logic ALCNR, and shows exactly when a hybrid language with decidable inference can be obtained. First, we show that several of the core constructors of description logics lead by themselves to undecidability of inference when combined with recursive function-free Horn rules. We then show that without these constructors we obtain a maximal subset of ALCNRR that yields a decidable hybrid language. Finally, we describe a restriction on the Horn rules that guarantees decidable inference when combined with all of ALCNR, and covers many of the common usages of recursive rules.

  20. Large loudspeaker horns and crated Edison radios from 1929 are ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Large loudspeaker horns and crated Edison radios from 1929 are stored in a side room on the third floor. - Thomas A. Edison Laboratories, Building No. 5, Main Street & Lakeside Avenue, West Orange, Essex County, NJ

  1. Ultra-wideband horn antenna with abrupt radiator

    DOEpatents

    McEwan, Thomas E.

    1998-01-01

    An ultra-wideband horn antenna transmits and receives impulse waveforms for short-range radars and impulse time-of flight systems. The antenna reduces or eliminates various sources of close-in radar clutter, including pulse dispersion and ringing, sidelobe clutter, and feedline coupling into the antenna. Dispersion is minimized with an abrupt launch point radiator element; sidelobe and feedline coupling are minimized by recessing the radiator into a metallic horn. Low frequency cut-off associated with a horn is extended by configuring the radiator drive impedance to approach a short circuit at low frequencies. A tapered feed plate connects at one end to a feedline, and at the other end to a launcher plate which is mounted to an inside wall of the horn. The launcher plate and feed plate join at an abrupt edge which forms the single launch point of the antenna.

  2. Ultra-wideband horn antenna with abrupt radiator

    DOEpatents

    McEwan, T.E.

    1998-05-19

    An ultra-wideband horn antenna transmits and receives impulse waveforms for short-range radars and impulse time-of flight systems. The antenna reduces or eliminates various sources of close-in radar clutter, including pulse dispersion and ringing, sidelobe clutter, and feedline coupling into the antenna. Dispersion is minimized with an abrupt launch point radiator element; sidelobe and feedline coupling are minimized by recessing the radiator into a metallic horn. Low frequency cut-off associated with a horn is extended by configuring the radiator drive impedance to approach a short circuit at low frequencies. A tapered feed plate connects at one end to a feedline, and at the other end to a launcher plate which is mounted to an inside wall of the horn. The launcher plate and feed plate join at an abrupt edge which forms the single launch point of the antenna. 8 figs.

  3. [Rudimentary horn pregnancy diagnostic: difficulties and therapeutic management].

    PubMed

    Mamouni, Nisrine; Ghazal, Nabil; Erraghay, Sanaa; Bouchikhi, Chahrazed; Banani, Abdelaziz

    2016-01-01

    The occurrence of rudimentary horn pregnancy is an extremely rare and potentially serious obstetric entity, threatening maternal and fetal outcome. The authors report five cases of rudimentary horn pregnancy, the difficulties in making a proper diagnosis and the therapeutic management of this pathological entity, stressing the importance of transvaginal ultrasound, of pelvic MRI and laparoscopy in the early diagnosis of this type of uterine malformation. PMID:27583078

  4. Pyogenic granuloma underlying cutaneous horn in a young boy.

    PubMed

    Nair, Pragya A; Kota, Rahul Krishna S; Pilani, Abhisheik P

    2016-01-01

    Cutaneous horn is an elongated, keratinous projection that usually occurs over the sun-exposed areas. It is a clinical diagnosis and may overlie any benign, premalignant, or malignant conditions. Treatment includes wide surgical excision with careful histological examination to exclude a focus of malignancy. An unusual case of a pyogenic granuloma presenting as cutaneous horn on the lower lip in an 11-year-old boy is presented here. PMID:27057494

  5. Pyogenic granuloma underlying cutaneous horn in a young boy

    PubMed Central

    Nair, Pragya A.; Kota, Rahul Krishna S.; Pilani, Abhisheik P.

    2016-01-01

    Cutaneous horn is an elongated, keratinous projection that usually occurs over the sun-exposed areas. It is a clinical diagnosis and may overlie any benign, premalignant, or malignant conditions. Treatment includes wide surgical excision with careful histological examination to exclude a focus of malignancy. An unusual case of a pyogenic granuloma presenting as cutaneous horn on the lower lip in an 11-year-old boy is presented here. PMID:27057494

  6. Water resources of Big Horn County, Wyoming

    USGS Publications Warehouse

    Plafcan, Maria; Cassidy, E.W.; Smalley, M.L.

    1993-01-01

    Groundwater in unconsolidated aquifers is the most reliable and accessible source of potable water in Big Horn County, Wyoming. Well yields generally ranged from 25 to 200 gal/min; however, yields of 1600 gal/min are reported from wells in the gravel, pediment, and fan deposits. Bedrock aquifers that yield the most abundant water supplies are the Tensleep Sandstone, Madison Limestone, Bighorn Dolomite, and Flathead Sandstone. The Madison Limestone, the Darby Formation, and the Bighorn Dolomite form the Madison/Bighorn aquifer. Shut-in pressure from flowing wells in bedrock indicate declines, from the time the wells were completed to 1988, by as much as 390 ft. Water samples from wells completed,in unconsolidated aquifers had concentration of dissolved solids less than 2000 mg/L. Water samples from wells in aquifers in Paleozoic and Precambrian rocks had median concentrations of dissolved solids ranging from 111 to 275 mg/L. Perennial streams originate in the mountains and ephemeral streams originate in the Bighorn Basin. The predominant dissolved constituents are calcium or sodium and bicarbonate or sulfate. Concentrations of pesticides detected in surface-water samples were less than the U.S. Environmental Protection Agency (USEPA) maximum contaminant levels. Pesticides detected in groundwater samples included dicamba and picloram at a concentration of 0.40 microg/L, atrazines (0.40 microg/L), aldicarb sulfoxide (1.44 microg/L), aldicarb sulfoxide (0.52 microg/L), and malathion (0.02 microg/L). Analyses of groundwater samples for radionuclides indicated that concentrations from four municipal wells exceeded the maximum contaminant levels established by the USEPA. Surface water accounts for 96 percent and groundwater accounts for 4 percent of total off-stream water use in Big Horn County. Irrigation is the largest off-stream use of both surface and groundwater. Groundwater supplies 89 percent of water used for domestic purposes and about 16 percent of water used

  7. Restoration of the Golden Horn Estuary (Halic).

    PubMed

    Coleman, Heather M; Kanat, Gurdal; Aydinol Turkdogan, F Ilter

    2009-12-01

    Restoration of the iconic Golden Horn Estuary in Istanbul, Turkey was a substantial political, logistical, ecological, and social challenge. Forty years of uncontrolled industrial and urban growth resulted in thick layers of anoxic sediment, toxic bacteria, strong hydrogen sulfide odor, and ecologically unlivable conditions. The major components of restoration, spanning two decades, have included (1) demolition and relocation of industries and homes along the shore, (2) creation of wastewater infrastructure, (3) removal of anoxic sludge from the estuary, (4) removal of a floating bridge that impeded circulation, and (5) creation of cultural and social facilities. Although Turkey is not known as an environmental leader in pollution control, the sum of these efforts was largely successful in revitalizing the area through dramatic water quality improvement. Consequently, the estuary is once again inhabitable for aquatic life as well as amenable to local resource users and foreign visitors, and Istanbul has regained a lost sense of cultural identity. This paper focuses on literature review and personal interviews to discuss the causes of degradation, solutions employed to rehabilitate the estuary, and subsequent physicochemical, ecological, and social changes. PMID:19781731

  8. Thirty years of collaboration with Gabriel Horn.

    PubMed

    Bateson, Patrick

    2015-03-01

    All the collaborative work described in this review was on the process of behavioural imprinting occurring early in the life of domestic chicks. Finding a link between learning and a change in the brain was only a first step in establishing a representation of the imprinting object. A series of overlapping experiments were necessary to eliminate alternative explanations. Once completed, a structure, the intermediate and medial mesopallium (IMM), was found to be strongly linked to the formation of a neural representation of the object used for imprinting the birds. With the site identified, lesion experiments showed that it was necessary for imprinting but not associative learning. Also the two sides of the brain responded differently with the left IMM acting as a permanent store and the right side acting as a way station to other parts of the brain. The collaborative work led to many studies by Gabriel Horn with others on the molecular and cellular bases of imprinting, and also to neural net modelling and behavioural studies with me on the nature of category formation in intact animals. PMID:25305059

  9. Reinforced concrete offshore platform

    SciTech Connect

    Martyshenko, J.P.; Martyshenko, S.J.; Kotelnikov, J.S.; Kutukhtin, E.G.; Petrosian, M.S.; Ilyasova, N.I.; Volkov, J.S.; Vardanian, A.M.

    1987-10-20

    A reinforced concrete offshore platform is described comprising a honeycomb foundation (A), a supporting structure (B) and an above-surface section (C) carrying appropriate equipment. The honeycomb foundation (A) and the supporting structure (B) are made of prefabricated reinforced concrete elements which are polyhedral hollow prisms arranged with gaps between the external sides thereof and joined by a system of prestressed vertical diaphragm walls and horizontal diaphragm walls formed by pre-tensioning reinforcing bars placed in the gaps between the faces of the prisms and casting in-situ the gaps later on.

  10. A nucleolar localizing Rev binding element inhibits HIV replication

    PubMed Central

    Michienzi, Alessandro; De Angelis, Fernanda G; Bozzoni, Irene; Rossi, John J

    2006-01-01

    The Rev protein of the human immunodeficiency virus (HIV) facilitates the nuclear export of intron containing viral mRNAs allowing formation of infectious virions. Rev traffics through the nucleolus and shuttles between the nucleus and cytoplasm. Rev multimerization and interaction with the export protein CRM1 takes place in the nucleolus. To test the importance of Rev nucleolar trafficking in the HIV-1 replication cycle, we created a nucleolar localizing Rev Response Element (RRE) decoy and tested this for its anti-HIV activity. The RRE decoy provided marked inhibition of HIV-1 replication in both the CEM T-cell line and in primary CD34+ derived monocytes. These results demonstrate that titration of Rev in the nucleolus impairs HIV-1 replication and supports a functional role for Rev trafficking in this sub-cellular compartment. PMID:16712721

  11. Effects of measurement dependence on generalized Clauser-Horne-Shimony-Holt Bell test in the single-run and multiple-run scenarios

    NASA Astrophysics Data System (ADS)

    Li, Dan-Dan; Zhou, Yu-Qian; Gao, Fei; Li, Xin-Hui; Wen, Qiao-Yan

    2016-07-01

    Bell tests, as primitive tools to detect nonlocality in bipartite systems, rely on an assumption, i.e., measurement independence. Since ensuring measurement independence in a practical Bell test is difficult, it is crucial to explore the effects of relaxing this assumption. Recently, in the simplest Clauser-Horne-Shimony-Holt Bell (CHSH-Bell) test, Koh et al. [Phys. Rev. Lett. 109, 160404 (2012), 10.1103/PhysRevLett.109.160404] built the relation among measurement dependence, guessing probability, and the maximum value of CHSH-Bell correlation function that an adversary (Eve) can fake. As well, Pope et al. [Phys. Rev. A 88, 032110 (2013), 10.1103/PhysRevA.88.032110] and Yuan et al. [Phys. Rev. A. 91, 032111 (2015), 10.1103/PhysRevA.91.032111] settled the same problem in the multiple-run scenario with the general input distribution and the factorizable one, respectively. However, pertinent results in the generalized CHSH-Bell test are still missing. Here, we study this problem and establish the relation among measurement dependence, guessing probability, and the maximum value of the generalized CHSH-Bell correlation function that Eve can fake. Furthermore, we also consider the multiple-run scenario and show the relations in both input distributions. Interestingly, compared with the simplest CHSH-Bell test, we find that it is more difficult for Eve to fake a violation in the generalized CHSH-Bell test in some special cases. We expect that our conclusions will serve as a reference for quantum information processing tasks such as quantum key distribution, randomness expansion, and other tasks in the device-independent framework.

  12. Offshore outlook: the American Arctic

    SciTech Connect

    Jahns, M.O.

    1985-05-01

    Offshore areas in the American Arctic are highlighted and the development of the area is compared with other offshore areas where the required technology is more readily available. Principal areas are shown in which new concepts are being put to practice. Canada's east coast is examined. Several technological trends are reviewed to help operators accelerate the discovery and development of arctic petroleum reserves.

  13. Towers for Offshore Wind Turbines

    NASA Astrophysics Data System (ADS)

    Kurian, V. J.; Narayanan, S. P.; Ganapathy, C.

    2010-06-01

    Increasing energy demand coupled with pollution free production of energy has found a viable solution in wind energy. Land based windmills have been utilized for power generation for more than two thousand years. In modern times wind generated power has become popular in many countries. Offshore wind turbines are being used in a number of countries to tap the energy from wind over the oceans and convert to electric energy. The advantages of offshore wind turbines as compared to land are that offshore winds flow at higher speed than onshore winds and the more available space. In some land based settings, for better efficiency, turbines are separated as much as 10 rotor diameters from each other. In offshore applications where only two wind directions are likely to predominate, the distances between the turbines arranged in a line can be shortened to as little as two or four rotor diameters. Today, more than a dozen offshore European wind facilities with turbine ratings of 450 kw to 3.6 MW exist offshore in very shallow waters of 5 to 12 m. Compared to onshore wind turbines, offshore wind turbines are bigger and the tower height in offshore are in the range of 60 to 80 m. The water depths in oceans where offshore turbines can be located are within 30 m. However as the distance from land increases, the costs of building and maintaining the turbines and transmitting the power back to shore also increase sharply. The objective of this paper is to review the parameters of design for the maximum efficiency of offshore wind turbines and to develop types offshore towers to support the wind turbines. The methodology of design of offshore towers to support the wind turbine would be given and the environmental loads for the design of the towers would be calculated for specific cases. The marine corrosion on the towers and the methods to control the corrosion also would be briefly presented. As the wind speeds tend to increase with distance from the shore, turbines build father

  14. Pioneering offshore excellence

    SciTech Connect

    Kent, R.P.; Grattan, L.

    1996-11-01

    Hibernia Management and Development Company Ltd. (HMDC) was formed in 1990 by a consortium of oil companies to develop their interests in the Hibernia and Avalon reservoirs offshore Newfoundland in a safe and environmentally responsible manner. The reservoirs are located 315km ESE of St. John`s in the North Atlantic. The water depth is about 80m. The entire Hibernia field is estimated to contain more than three billion barrels of oil in place and the owners development plan area is estimated to contain two billion barrels. Recoverable reserves are estimated to be approximately 615 million barrels. The Hibernia reservoir, the principle reservoir, is located at an average depth of 3,700m. HMDC is building a large concrete gravity based structure (GBS) that which will support the platform drilling and processing facilities and living quarters for 280 personnel. In 1997 the platform will be towed to the production site and production will commence late 1997. Oil will be exported by a 2 km long pipeline to an offshore loading system. Dynamically positioned tankers will then take the oil to market. Average daily production is expected to plateau between 125,000 and 135,000 BOPD. It will be the first major development on the east coast of Canada and is located in an area that is prone to pack ice and icebergs.

  15. Offshore production challenged

    SciTech Connect

    Franco, A.

    1983-10-01

    The capability to produce oil fields from under 20,000 ft of water or below the thick and treacherous Arctic icepack are 2 of the breakthroughs that have been brought about by a quietly emerging technology. A scan of announcements by designers, contractors, operators, and manufacturers reveals that substantial research and development efforts are being undertaken to ease the task of bringing to market the energy resources trapped under presently inaccessible locations. As a result, entirely new breeds of permanent or temporary drilling/production systems are evolving, some of which could be scaled down to face still another challenge: the economic exploitation of marginal offshore fields, whose meager reserves do not justify development by conventional means. New offshore systems described include the mobile Arctic drilling system, the mobile concrete island drilling system, the base and independent deck platform, the buoyant tower, the semiflex floating station, the tension leg platform, the big buoy floating cylinder, and the Sea Plex retrievable drilling/production system.

  16. Suppression of atherosclerosis by synthetic REV-ERB agonist

    SciTech Connect

    Sitaula, Sadichha; Billon, Cyrielle; Kamenecka, Theodore M.; Solt, Laura A.; Burris, Thomas P.

    2015-05-08

    The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agonists that we have developed might have the ability to suppress atherosclerosis in this model. A previously characterized synthetic REV-ERB agonist, SR9009, was used to determine if activation of REV-ERB activity would affect atherosclerosis in LDL receptor deficient mice. Atherosclerotic plaque size was significantly reduced (p < 0.05) in mice administered SR9009 (100 mg/kg) for seven weeks compared to control mice (n = 10 per group). SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to proinflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages. Our results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for treatment of atherosclerosis. - Highlights: • Synthetic REV-ERB agonist treatment reduced atherosclerosis in a mouse model. • Pharmacological activation of REV-ERB decreased M1 macrophage polarization. • Pharmacological activation of REV-ERB increased M2 macrophage polarization.

  17. Variation of dorsal horn cell dendritic spread with map scale.

    PubMed

    Brown, P B; Millecchia, R; Culberson, J L; Gladfelter, W; Covalt-Dunning, D

    1996-10-21

    Cells in laminae III, IV, and V of cat dorsal horn were injected with horseradish peroxidase or neurobiotin. Dorsal views of the dendritic domains were constructed in order to measure their lengths, widths, areas, and length/width ratios in the horizontal plane (the plane of the somatotopic map). Dendritic domain width and area in the horizontal plane were negatively correlated with fractional distance between the medial and lateral edges of the dorsal horn. These results are consistent with the hypothesis that dendritic domain width varies with map scale, which is maximal in the medial dorsal horn. This is similar to the variation in widths of primary afferent bouton distributions. The parallel variation of dorsal horn cell dendritic domain width and primary afferent bouton distribution width with map scale suggests that there is a causal relation between morphology and map scale in the dorsal horn representation of the hindlimb. This variation of adult morphology with map scale must reflect mechanisms responsible for the assembly of receptive fields. PMID:8906504

  18. An unexpected near term pregnancy in a rudimentary uterine horn.

    PubMed

    Gonçalves, Elisabete; Prata, João Pedro; Ferreira, Sandra; Abreu, Rita; Mesquita, Jorge; Carvalho, Agostinho; Pinheiro, Paula

    2013-01-01

    Unicornuate uterus occurs due to a complete or partial nondevelopment of one Mullerian duct; sometimes it is associated with a rudimentary horn, which can communicate or not with uterine cavity or contain functional endometrium. Pregnancy in a rudimentary horn is rare and the outcome almost always unfavorable, usually ending in rupture during the first or second trimester with significant morbidity and mortality. Despite the availability and advances on imagiologic procedures, recognition of this ectopic pregnancy is frequently made at laparotomy after abdominal pain and collapse. The authors describe a case of a primigravida with 34 weeks of gestation admitted with a preeclampsia with severity criteria. A cesarean for fetal malpresentation was done and, unexpectedly, a rudimentary horn pregnancy was found with a live newborn. In the literature, few reports of a horn pregnancy reaching the viability with a live newborn are described, enhancing the clinical importance of this case. A review of literature concerning the epidemics, clinical presentation, and appropriate management of uterine horn pregnancies is made. PMID:23710390

  19. An Unexpected Near Term Pregnancy in a Rudimentary Uterine Horn

    PubMed Central

    Gonçalves, Elisabete; Prata, João Pedro; Abreu, Rita; Mesquita, Jorge; Carvalho, Agostinho; Pinheiro, Paula

    2013-01-01

    Unicornuate uterus occurs due to a complete or partial nondevelopment of one Mullerian duct; sometimes it is associated with a rudimentary horn, which can communicate or not with uterine cavity or contain functional endometrium. Pregnancy in a rudimentary horn is rare and the outcome almost always unfavorable, usually ending in rupture during the first or second trimester with significant morbidity and mortality. Despite the availability and advances on imagiologic procedures, recognition of this ectopic pregnancy is frequently made at laparotomy after abdominal pain and collapse. The authors describe a case of a primigravida with 34 weeks of gestation admitted with a preeclampsia with severity criteria. A cesarean for fetal malpresentation was done and, unexpectedly, a rudimentary horn pregnancy was found with a live newborn. In the literature, few reports of a horn pregnancy reaching the viability with a live newborn are described, enhancing the clinical importance of this case. A review of literature concerning the epidemics, clinical presentation, and appropriate management of uterine horn pregnancies is made. PMID:23710390

  20. Transverse electromagnetic horn antenna with resistively-loaded exterior surfaces

    DOEpatents

    Aurand, John F.

    1999-01-01

    An improved transverse electromagnetic (TEM) horn antenna comprises a resistive loading material on the exterior surfaces of the antenna plates. The resistive loading material attenuates or inhibits currents on the exterior surfaces of the TEM horn antenna. The exterior electromagnetic fields are of opposite polarity in comparison to the primary and desired interior electromagnetic field, thus inherently cause partial cancellation of the interior wave upon radiation or upon reception. Reducing the exterior fields increases the radiation efficiency of the antenna by reducing the cancellation of the primary interior field (supported by the interior surface currents). This increases the transmit gain and receive sensitivity of the TEM horn antenna, as well as improving the transient (time-domain) response.

  1. A Micro Ultrasonic Scalpel with Modified Stepped Horn

    NASA Astrophysics Data System (ADS)

    Kurosawa, Minoru; Umehara, Yuji

    A transducer for a micro ultrasonic scalpel has been fabricated. The micro ultrasonic scalpel can be used with an endoscope for a non-abdominal operation or micro surgery, for example, through a microscope. The ultrasonic transducer was 9.8 mm long and 2.7 mm wide and has stepped horn to amplify vibration velocity; tip of the horn is 0.6 mm wide. The scalpel operated at the resonance frequency in longitudinal mode of 278 kHz. The piezoelectric material was lead zirconate titanate (PZT) that was deposited by the hydrothermal method. The vibration velocity at the tip of the horn in longitudinal direction was 4.0 m/s with 40Vp-p driving voltage in both side electrodes. To demonstrate a beneficial effect of the scalpel, a cutting test that the transducer was stuck into pork fat was carried out.

  2. Detecting flaws in Portland cement concrete using TEM horn antennae

    NASA Astrophysics Data System (ADS)

    Al-Qadi, Imad L.; Riad, Sedki M.; Su, Wansheng; Haddad, Rami H.

    1996-11-01

    To understand the dielectric properties of PCC and better correlate them with type and severity of PCC internal defects, a study was conducted to evaluate PCC complex permittivity and magnetic permeability over a wideband of frequencies using both time domain and frequency domain techniques. Three measuring devices were designed and fabricated: a parallel plate capacitor, a coaxial transmission line, and transverse electromagnetic (TEM) horn antennae. The TEM horn antenna covers the microwave frequencies. The measurement technique involves a time domain setup that was verified by a frequency domain measurement. Portland cement concrete slabs, 60 by 75 by 14 cm, were cast; defects include delamination, delamination filled with water, segregation, and chloride contamination. In this paper, measurements using the TEM horn antennae and the feasibility of detecting flaws at microwave frequency are presented.

  3. Ice interaction with offshore structures

    SciTech Connect

    Cammaert, A.B.; Muggeridge, D.B.

    1988-01-01

    Oil platforms and other offshore structures being built in the arctic regions must be able to withstand icebergs, ice islands, and pack ice. This reference explain the effect ice has on offshore structures and demonstrates design and construction methods that allow such structures to survive in harsh, ice-ridden environments. It analyzes the characteristics of sea ice as well as dynamic ice forces on structures. Techniques for ice modeling and field testing facilitate the design and construction of sturdy, offshore constructions. Computer programs included.

  4. [Gene expression profile of spinal ventral horn in ALS].

    PubMed

    Yamamoto, Masahiko; Tanaka, Fumiaki; Sobue, Gen

    2007-10-01

    The causative pathomechanism of sporadic amyotrophic lateral sclerosis (ALS) is not clearly understood. Using microarray technology combined with laser-captured microdissection, gene expression profiles of degenerating spinal motor neurons as well as spinal ventral horn from autopsied patients with sporadic ALS were examined. Spinal motor neurons showed a distinct gene expression profile from the whole spinal ventral horn. Three percent of genes examined were significantly downregulated, and 1% were upregulated in motor neurons. In contrast with motor neurons, the total spinal ventral horn homogenates demonstrated 0.7% and 0.2% significant upregulation and downregulation of gene expression, respectively. Downregulated genes in motor neurons included those associated with cytoskeleton/axonal transport, transcription and cell surface antigens/receptors, such as dynactin 1 (DCTN1) and early growth response 3 (EGR3). In particular, DCTN1 was markedly downregulated in most residual motor neurons prior to the accumulation of pNF-H and ubiquitylated protein. Promoters for cell death pathway, death receptor 5 (DR5), cyclins C (CCNC) and A1 (CCNA), and caspases were upregulated, whereas cell death inhibitors, acetyl-CoA transporter (ACATN) and NF-kappaB (NFKB) were also upregulated. In terms of spinal ventral horn, the expression of genes related to cell surface antigens/receptors, transcription and cell adhesion/ECM were increased. The gene expression resulting in neurodegenerative and neuroprotective changes were both present in spinal motor neurons and ventral horn. Moreover, Inflammation-related genes, such as belonging to the cytokine family were not, however, significantly upregulated in either motor neurons or ventral horn. The sequence of motor neuron-specific gene expression changes from early DCTN1 downregulation to late CCNC upregulation in sporadic ALS can provide direct information on the genes leading to neurodegeneration and neuronal death, and are helpful

  5. a Modeling and Measurement Study of Acoustic Horns

    NASA Astrophysics Data System (ADS)

    Post, John Theodore

    Although acoustic horns have been in use for thousands of years, formal horn design only began approximately 80 years ago with the pioneering effort of A. G. Webster. In this dissertation, the improvements to Webster's original horn model are reviewed and the lack of analytical progress since Webster is noted. In an attempt to augment the traditional methods of analysis, a semi-analytical technique presented by Rayleigh is extended. Although Rayleigh's method is not based on one-dimensional wave propagation, it is found not to offer significant improvement over Webster's model. In order to be free of the limitations associated with analytical techniques, a numerical method based on boundary elements has been developed. It is suitable for solving radiation problems that can be modeled as a source in an infinite bafffe. The exterior boundary element formulation is exchanged for an interior formulation by placing a hemisphere over the baffled source and using an analytical expansion of the field in the exterior half space. The boundary element method is demonstrated by solving the baffled piston problem, and is then used to obtain the acoustic throat impedance and far-field directivity of axisymmetric horns having exponential and tractrix contours. Experiments are performed to measure the throat impedance and the far-field directivity of two axisymmetric horns mounted in a rigid baffle. An exponential horn and a tractrix horn with equal throat radius (2.54 cm), length (55.9 cm), and mouth radius (27.1 cm) are critically examined. A modern implementation of the "reaction on the source" method is compared with a new implementation of the two-microphone method for measuring acoustic impedance. The modified two-microphone method is found to be extremely simple and accurate, but the "reaction on the source" method has the advantage of in situ measurements. The far-field directivity is measured by a new technique that allows the far-field pressure to be calculated from the

  6. Coupling and degenerating modes in longitudinal-torsional step horns.

    PubMed

    Harkness, Patrick; Lucas, Margaret; Cardoni, Andrea

    2012-12-01

    Longitudinal-torsional vibration is used and proposed for a variety of ultrasonic applications including motors, welding, and rock-cutting. To obtain this behavior in an ultrasonic step horn one can either, (i) couple the longitudinal and torsional modes of the horn by incorporating a ring of diagonal slits in the thick base section or, (ii) place helical flutes in the thin stem section to degenerate the longitudinal mode into a modified behavior with a longitudinal-torsional motion. This paper compares the efficacy of these two design approaches using both numerical and experimental techniques. PMID:22770885

  7. Inclusion body disease in a great horned owl.

    PubMed

    Sileo, L; Carlson, H C; Crumley, S C

    1975-01-01

    The carcass of a great horned owl (Bubo virginianus), which had been found moribund in southern Ontario, was presented for necropsy. Throughout the liver and spleen were numerous white foci 1-2 mm in diameter; also noted were white plaques in the mucosae of the pharyngeal papillae and intestine. Results of light and electron microscopic studies and experimental transmission to two captive great horned owls suggested that this was a herpvirus disease similar and possibly indentical to the owl disease reported by other workers in Wiconsin and Australia. PMID:163384

  8. [Pregnancy in a rudimentary horn of the uterus].

    PubMed

    Sroczyński, Tomasz

    2014-01-01

    Pregnancy in a rudimentary horn of the uterus, a rare form of ectopic pregnancy, develops in women affected by developmental abnormalities of the growth and fusion of the Müllerian paramesonephric ducts. In the Polish population, this problem affects 4-8 women per year. The paper analyzes the problems that are associated with pregnancy developing in the rudimentary horn. Due to the continuous progress in medical sciences, maternal mortality has been almost completely eliminated in this form of ectopic pregnancy, while neonatal survival has risen to about 20%. Further devel- opments in medicine allow us to be moderately optimis- tic about further improvement of the treatment's statistics. PMID:25518088

  9. Gain calibration of a horn antenna using pattern integration

    NASA Technical Reports Server (NTRS)

    Ludwig, A. C.; Hardy, J.; Norman, R.

    1972-01-01

    Gain measurement of a horn antenna using three different techniques is discussed. The methods include a two-antenna insertion loss measurement, a pattern integration method, and a near-field measurement method. The application of the pattern integration method is considered, as well as the evaluation of the near-field gain correction factors for the horn, which are determined by a method based directly on measured data. This method involves a spherical wave expansion of the experimental radiation pattern of the specific antenna being tested, rather than evaluation of an assumed analytical model. The spherical wave expansion is also compared to experimental near-field pattern data.

  10. Mechanical properties of the bovine claw horn during lactation.

    PubMed

    Winkler, B; Margerison, J K

    2012-04-01

    Claw horn disorders are one of the main causes of lameness in dairy cows globally. This study aimed to develop material testing techniques to assess changes in the mechanical properties of bovine claw horn (BCH) and to compare these mechanical properties with existing methods of assessing claw horn disorders during lactation. Lameness was also measured through locomotion scoring to assess the clinical significance of changes observed in the scoring for lesions. Experiment 1 used 8 claws collected from four 12 to 18 mo old beef heifers, to develop BCH sample storage methods and techniques to test the mechanical properties of BCH (puncture resistance and elastic modulus). The increase in the moisture content of BCH had a significant negative exponential effect on the elastic modulus of the sole and white line claw horn and a linear reduction in the puncture resistance of BCH. Placing BCH samples in sealed plastic bags and storing them either at 2°C or by freezing samples at -22°C did not alter the dry matter content and, consequently, the mechanical properties of the claw horn tissue. In experiment 2, BCH was collected from 36 lactating dairy cows and mechanical properties were tested using puncture resistance. Puncture resistance of the sole area of the claw horn decreased significantly when hemorrhages in the tested area increased. The puncture resistance of the sole and white line areas decreased at d 160 postpartum when the cows exhibited higher lesion scores and was lower in hind claws that had higher lesion scores when compared with the fore claws. The highest puncture resistance was found at 270 d postpartum, when the animals were at pasture. Puncture resistance was found to be an effective technique for assessing the effect of period of lactation and increasing hemorrhage levels on the mechanical properties and structural strength of bovine claw horn. It was found to be a good method of comparing changes and differences in mechanical properties and

  11. A new proof of tractability for ORD-horn relations

    SciTech Connect

    Ligozat, G.

    1996-12-31

    This paper gives an elementary proof of the tractability of a sub-class of temporal relations in Allen`s algebra and related temporal calculi, the class of pre-convex relations. In Allen`s case, this subclass coincides with the class of ORD-Horn relations. Nebel and Burckert defined ORD-Horn relations and proved that path-consistency is a sufficient condition for consistency of a network for this sub-class. We prove a stronger result: for each path-consistent network in the sub-class, we give an effective method for constructing a feasible scenario without backtrack.

  12. [Recurrence of a rudimentary uterine horn rupture at 25 weeks of gestation: a case report].

    PubMed

    Schmied, R; Sentilhes, L; Baron, M; Grzegorczyk, V; Resch, B; Marpeau, L

    2008-03-01

    Pregnancy in a rudimentary uterine horn is a rare event which can be revealed by uterine rupture. Following the fetal extraction, some authors recommend the ablation of the rudimentary horn, in order to limit the risk of uterine rupture in case of subsequent pregnancy in the same horn. We report the obstetrical outcome of a patient with a history of rudimentary uterine horn rupture the treatment of which was conservative. PMID:18308608

  13. Offshore search continues despite disappointments

    SciTech Connect

    Cornitius, T.

    1985-05-01

    Exploration drilling activity in Australia broke records onshore in 1984, but offshore it was a different story. A total of 373 wells were drilled, onshore and offshore, with 266 labeled as wildcats and appraisals. Out of 80 wells drilled offshore last year, 43 were exploratory compared with 49 in 1983; 48 were oil wells, seven were gas, and 25 were dusters. Offshore discoveries included the Talisman 1 off the coast of Western Australia, which tested around 6000 b/d, and Challis 1 in the Timor Sea, which flowed at 5000 b/d. The failure to establish Jabiru in the Timor Sea as a major oil province like Bass Strait was a major disappointment. However, the Challis 1 was a relief since it indicated the presence of a commercial field adjacent to Jabiru.

  14. 9 CFR 95.12 - Bones, horns, and hoofs; importations permitted subject to restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Bones, horns, and hoofs; importations... ENTRY INTO THE UNITED STATES § 95.12 Bones, horns, and hoofs; importations permitted subject to restrictions. Bones, horns, and hoofs offered for importation which do not meet the conditions or...

  15. Torsion of a rudimentary uterine horn at 22 weeks of gestation.

    PubMed

    Wang, Bo; Zhou, Jian-hong; Jin, Hang-mei

    2011-07-01

    Rudimentary uterine horn is an uncommon abnormality of the female reproductive tract. Torsion of rudimentary uterine horn in pregnancy is even rarer. A case of successful excision of distorted rudimentary uterine horn in the second trimester, which caused severe abdominal pain, is described. A congenital absence of the right kidney was discovered simultaneously. The pregnancy continued uneventfully until term delivery. PMID:21450021

  16. An Engaged Pragmatist: Uncovering and Assessing Ernest Horn's View of Moral Education

    ERIC Educational Resources Information Center

    Schul, James E.; Hamot, Gregory E.

    2011-01-01

    Ernest Horn was a curriculum professor at The University of Iowa in the early to mid-twentieth century. Predominantly known at the time for his spelling research, Horn also made important contributions to the field of social studies education. This historical inquiry illuminates one of Horn's contributions to social studies education by examining…

  17. 9 CFR 95.12 - Bones, horns, and hoofs; importations permitted subject to restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Bones, horns, and hoofs; importations... ENTRY INTO THE UNITED STATES § 95.12 Bones, horns, and hoofs; importations permitted subject to restrictions. Bones, horns, and hoofs offered for importation which do not meet the conditions or...

  18. RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev–Rev response element complex

    PubMed Central

    Jayaraman, Bhargavi; Crosby, David C; Homer, Christina; Ribeiro, Isabel; Mavor, David; Frankel, Alan D

    2014-01-01

    The HIV-1 protein Rev controls a critical step in viral replication by mediating the nuclear export of unspliced and singly-spliced viral mRNAs. Multiple Rev subunits assemble on the Rev Response Element (RRE), a structured region present in these RNAs, and direct their export through the Crm1 pathway. Rev-RRE assembly occurs via several Rev oligomerization and RNA-binding steps, but how these steps are coordinated to form an export–competent complex is unclear. Here, we report the first crystal structure of a Rev dimer-RRE complex, revealing a dramatic rearrangement of the Rev-dimer upon RRE binding through re-packing of its hydrophobic protein–protein interface. Rev-RNA recognition relies on sequence-specific contacts at the well-characterized IIB site and local RNA architecture at the second site. The structure supports a model in which the RRE utilizes the inherent plasticity of Rev subunit interfaces to guide the formation of a functional complex. DOI: http://dx.doi.org/10.7554/eLife.04120.001 PMID:25486594

  19. Reassessment of offshore platforms

    SciTech Connect

    Nair, V.V.D.; Kuhn, J.M. )

    1993-05-01

    Data from Hurricane Andrew demonstrated that the systems and procedures in place for evacuating offshore workers and minimizing oil spills and environmental damage functioned as planned. While the vast majority of the platforms survived the storm with no damage, a few of the older platforms (installed prior to 1972) either collapsed or suffered severe damage. The collapsed platforms were designed with insufficient deck height to clear the storm waves. In recent years, the API RP 2A has introduced guidance for minimum air gap, minimum structures, platform inspection and platform reuse. These provisions, coupled with natural attribution of the older platforms, will significantly improve the performance of platforms in the future. The reliability of NDT techniques to detect major structural defects should be improved through continued research. While flooded member detection is used by several operators as a screening tool to detect major defects underwater, its reliability is not always good and further research is needed in this area. Another area of high priority research is related to the use of Remotely Operated Vehicles (ROV) to perform underwater inspection of structures. 51 refs., 7 figs.

  20. Past and future rainfall in the Horn of Africa

    PubMed Central

    Tierney, Jessica E.; Ummenhofer, Caroline C.; deMenocal, Peter B.

    2015-01-01

    The recent decline in Horn of Africa rainfall during the March–May “long rains” season has fomented drought and famine, threatening food security in an already vulnerable region. Some attribute this decline to anthropogenic forcing, whereas others maintain that it is a feature of internal climate variability. We show that the rate of drying in the Horn of Africa during the 20th century is unusual in the context of the last 2000 years, is synchronous with recent global and regional warming, and therefore may have an anthropogenic component. In contrast to 20th century drying, climate models predict that the Horn of Africa will become wetter as global temperatures rise. The projected increase in rainfall mainly occurs during the September–November “short rains” season, in response to large-scale weakening of the Walker circulation. Most of the models overestimate short rains precipitation while underestimating long rains precipitation, causing the Walker circulation response to unrealistically dominate the annual mean. Our results highlight the need for accurate simulation of the seasonal cycle and an improved understanding of the dynamics of the long rains season to predict future rainfall in the Horn of Africa. PMID:26601306

  1. Past and future rainfall in the Horn of Africa.

    PubMed

    Tierney, Jessica E; Ummenhofer, Caroline C; deMenocal, Peter B

    2015-10-01

    The recent decline in Horn of Africa rainfall during the March-May "long rains" season has fomented drought and famine, threatening food security in an already vulnerable region. Some attribute this decline to anthropogenic forcing, whereas others maintain that it is a feature of internal climate variability. We show that the rate of drying in the Horn of Africa during the 20th century is unusual in the context of the last 2000 years, is synchronous with recent global and regional warming, and therefore may have an anthropogenic component. In contrast to 20th century drying, climate models predict that the Horn of Africa will become wetter as global temperatures rise. The projected increase in rainfall mainly occurs during the September-November "short rains" season, in response to large-scale weakening of the Walker circulation. Most of the models overestimate short rains precipitation while underestimating long rains precipitation, causing the Walker circulation response to unrealistically dominate the annual mean. Our results highlight the need for accurate simulation of the seasonal cycle and an improved understanding of the dynamics of the long rains season to predict future rainfall in the Horn of Africa. PMID:26601306

  2. Bioassay improvements for assessing pyrethroid resistance in horn flies

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The horn fly (Haematobia irritans) is a major cattle pest in the American continent, causing yearly economic losses of over US $860 million in Brazil. Frequent use of chemical insecticides has led to the development of insecticide resistance, leading to significant economic losses and environmental ...

  3. Ventral horn cell responses to spaceflight and hindlimb suspension

    NASA Technical Reports Server (NTRS)

    Jiang, Bian; Roy, Roland R.; Poliakov, I. V.; Krasnov, I. B.; Edgerton, V. R.

    1992-01-01

    Ventral horn cells of the lumbosacral enlargement of the spinal cord were studied focusing on the succinate dehydrogenase (SDH) activity and cross-sectional area of the soma of ventral horn cells which were measured using a computer-aided image-processing system. The relationships between the soma size and SDH activities of lumber ventral horn cells after 14 days of spaceflight (Cosmos 2044) or of hindlimb suspension are considered. Three groups of rats under consideration include control, 14-day spaceflight, and 14-day hindlimb suspension. Data obtained indicate that, compared to the control group, the population distribution of SDH activities in the flight rats shifted toward higher activities, whereas in the suspended rats the distribution shifted toward lower activities. The interactive effects within individual cells showed that there was a higher percentage of small cells with high SDH activities in the flight than in the control or suspended rats. It is suggested that changes in ventral horn cells were due to factors other than simply the absence of weight support.

  4. New gene coding regions from the horn fly, Haematobia irritans

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We used an EST approach to isolate new gene coding regions from the horn fly, Haematobia irritans. Two sources of expressed gene sequences were utilized. First, a subtracted library was synthesized from adult mixed sex fly cDNA of an organophosphate and pyrethroid resistant population of flies subtr...

  5. Spatial patterns in the abundance of the coastal horned lizard

    USGS Publications Warehouse

    Fisher, R.N.; Suarez, A.V.; Case, T.J.

    2002-01-01

    Coastal horned lizards (Phrynosoma coronatum) have undergone severe declines in southern California and are a candidate species for state and federal listing tender the Endangered Species Act. Quantitative data on their habitat use, abundance, and distribution are lacking, however. We investigated the determinants of abundance for coastal horned lizards at multiple spatial scales throughout southern California. Specifically, we estimated lizard distribution and abundance by establishing 256 pitfall trap arrays clustered within 21 sites across four counties. These arrays were sampled bimonthly for 2-3 years. At each array we measured 26 "local" site descriptors and averaged these values with other "regional" measures to determine site characteristics. Our analyses were successful at identifying factors within and among sites correlated with the presence and abundance of coastal horned lizards. These factors included the absence of the invasive Argentine ant (Linepithema humile) (and presence of native ant species eaten by the lizards), the presence of chaparral community plants, and the presence of sandy substrates. At a regional scale the relative abundance of Argentine ants was correlated with the relative amount of developed edge around a site. There was no evidence for spatial autocorrelation, even at the scale of the arrays within sites, suggesting that the determinants of the presence or absence and abundance of horned lizard can vary over relatively small spatial scales (hundreds of meters). Our results suggest that a gap-type approach may miss some of the fine-scale determinants of species abundance in fragmented habitats.

  6. Rudimentary horn pregnancy with herniation into the main uterine cavity.

    PubMed

    Fitzmaurice, Laura E; Ehsanipoor, Robert M; Porto, Manuel

    2010-03-01

    We report a case of a rudimentary horn pregnancy with herniation of a fetal arm and umbilical cord into the main uterine cavity that presented as an incidental finding on a routine second-trimester ultrasound scan. We also review the literature that guides the diagnosis and management of these rare complicated pregnancies. PMID:20207232

  7. Vegetative endocarditis in a scimitar-horned oryx (Oryx dammah).

    PubMed

    Chai, N

    1999-12-01

    Streptococcus uberis was cultured from vegetative endocarditis lesions in a scimitar-horned oryx (Oryx dammah) from the Parc de la Haute Touche, France. This is the first reported single isolation of S. uberis from an oryx with vegetative endocarditis leading to fatal congestive heart failure. PMID:10749451

  8. 30 CFR 56.14132 - Horns and backup alarms.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Horns and backup alarms. 56.14132 Section 56.14132 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Machinery and Equipment Safety Devices and...

  9. 30 CFR 56.14132 - Horns and backup alarms.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....14132 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Machinery and Equipment Safety Devices and Maintenance Requirements § 56.14132 Horns and backup alarms. (a)...

  10. 30 CFR 56.14132 - Horns and backup alarms.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....14132 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Machinery and Equipment Safety Devices and Maintenance Requirements § 56.14132 Horns and backup alarms. (a)...

  11. Dog-Bone Horns for Piezoelectric Ultrasonic/Sonic Actuators

    NASA Technical Reports Server (NTRS)

    Sherrit, Stewart; Bar-Cohen, Yoseph; Chang, Zensheu; Bao, Xiaoqi

    2007-01-01

    A shape reminiscent of a dog bone has been found to be superior to other shapes for mechanical-amplification horns that are components of piezoelectrically driven actuators used in a series of related devices denoted generally as ultrasonic/sonic drill/corers (USDCs). The first of these devices was reported in Ultrasonic/Sonic Drill/Corers With Integrated Sensors (NPO-20856), NASA Tech Briefs, Vol. 25, No. 1 (January 2001), page 38. The dog-bone shape was conceived especially for use in a more recent device in the series, denoted an ultrasonic/ sonic gopher, that was described in Ultrasonic/Sonic Mechanisms for Drilling and Coring (NPO-30291), NASA Tech Briefs, Vol. 27, No. 9 (September 2003), page 65. The figure shows an example of a dog-bone-shaped horn and other components of an ultrasonic gopher. Prerequisite to a meaningful description of this development is an unavoidably lengthy recapitulation of the principle of operation of a USDC and, more specifically, of the ultrasonic/sonic gopher as described previously in NASA Tech Briefs. The ultrasonic actuator includes a stack of piezoelectric rings, the horn, a metal backing, and a bolt that connects the aforementioned parts and provides compressive pre-strain to the piezoelectric stack to prevent breakage of the rings during extension. The stack of piezoelectric rings is excited at the resonance frequency of the overall ultrasonic actuator. Through mechanical amplification by the horn, the displacement in the ultrasonic vibration reaches tens of microns at the tip of the horn. The horn hammers an object that is denoted the free mass because it is free to move longitudinally over a limited distance between hard stops: The free mass bounces back and forth between the ultrasonic horn and a tool bit (a drill bit or a corer). Because the longitudinal speed of the free mass is smaller than the longitudinal speed of vibration of the tip of the horn, contact between the free mass and the horn tip usually occurs at a

  12. Offshore Wind Energy Market Overview (Presentation)

    SciTech Connect

    Baring-Gould, I.

    2013-07-01

    This presentation describes the current international market conditions regarding offshore wind, including the breakdown of installation costs, how to reduce costs, and the physical siting considerations considered when planning offshore wind construction. The presentation offers several examples of international existing and planned offshore wind farm sites and compares existing international offshore resources with U.S. resources. The presentation covers future offshore wind trends and cites some challenges that the United States must overcome before it will be able to fully develop offshore wind sites.

  13. Study of disbudding goat kids following injection of clove oil essence in horn bud region.

    PubMed

    Molaei, Mohammad Mahdi; Mostafavi, Ali; Kheirandish, Reza; Azari, Omid; Shaddel, Mohsen

    2015-01-01

    This study was performed to evaluate the efficacy of injection of essential oil of Eugenia caryophyllata in the kid horn buds, as a new chemical technique for disbudding. Five-day-old healthy goat kids from both sexes (n = 16) were divided randomly into 4 equal groups. In groups 1, 2 and 3, 0.2 mL of clove essence and in group 4 (control) 0.2 mL of normal saline was injected into the left horn bud of goat kids. Right horn bud in all kids was considered to ensure that they are horned. During the study, the rate of horn growth were evaluated in determined time intervals between groups 1 and 4. Tissue samples were taken from right and left horn bud in groups 2 and 3, at five and ten days after clove essence injection, for microscopic study. The results of the study showed that the clove essence stopped horn growth, whereas there was no significant difference in horn growth rate between left and right horns after injection of normal saline, in group 4. Histopathological study showed that injection of clove essence caused complete necrosis of epidermis and underlying dermis with collagenolysis in horn bud tissues, 5 days after injection and then progress in healing process was observed after 10 days. According to the results of this study, it can be concluded that the injection of clove essence is an effective method to stop horn growth without any undesirable effects on clinical parameters in goat kids. PMID:25992247

  14. Study of disbudding goat kids following injection of clove oil essence in horn bud region

    PubMed Central

    Molaei, Mohammad Mahdi; Mostafavi, Ali; Kheirandish, Reza; Azari, Omid; Shaddel, Mohsen

    2015-01-01

    This study was performed to evaluate the efficacy of injection of essential oil of Eugenia caryophyllata in the kid horn buds, as a new chemical technique for disbudding. Five-day-old healthy goat kids from both sexes (n = 16) were divided randomly into 4 equal groups. In groups 1, 2 and 3, 0.2 mL of clove essence and in group 4 (control) 0.2 mL of normal saline was injected into the left horn bud of goat kids. Right horn bud in all kids was considered to ensure that they are horned. During the study, the rate of horn growth were evaluated in determined time intervals between groups 1 and 4. Tissue samples were taken from right and left horn bud in groups 2 and 3, at five and ten days after clove essence injection, for microscopic study. The results of the study showed that the clove essence stopped horn growth, whereas there was no significant difference in horn growth rate between left and right horns after injection of normal saline, in group 4. Histopathological study showed that injection of clove essence caused complete necrosis of epidermis and underlying dermis with collagenolysis in horn bud tissues, 5 days after injection and then progress in healing process was observed after 10 days. According to the results of this study, it can be concluded that the injection of clove essence is an effective method to stop horn growth without any undesirable effects on clinical parameters in goat kids. PMID:25992247

  15. Changes in horn size of Stone's sheep over four decades correlate with trophy hunting pressure.

    PubMed

    Douhard, Mathieu; Festa-Bianchet, Marco; Pelletier, Fanie; Gaillard, Jean-michel; Bonenfanti, Christophe

    2016-01-01

    Selective harvest may lead to rapid evolutionary change. For large herbivores, trophy hunting removes males with large horns. That artificial selection, operating in opposition to sexual selection, can lead to undesirable consequences for management and conservation. There have been no comparisons of long-term changes in trophy size under contrasting harvest pressures. We analyzed horn measurements of Stone's rams (Ovis dalli stonei) harvested over 37 years in two large regions of British Columbia, Canada, with marked differences in hunting pressure to identify when selective hunting may cause a long-term decrease in horn growth. Under strong selective harvest, horn growth early in life and the number of males harvested declined by 12% and 45%, respectively, over the study period. Horn shape also changed over time: horn length became shorter for a given base circumference, likely because horn base is not a direct target of hunter selection. In contrast, under relatively lower hunting pressure, there were no detectable temporal trends in early horn growth, number of males harvested, or horn length relative to base circumference. Trophy hunting is an important recreational activity and can generate substantial revenues for conservation. By providing a reproductive advantage to males with smaller horns and reducing the availability of desirable trophies, however, excessive harvest may have the undesirable long-term consequences of reducing both the harvest and the horn size of rams. These consequences can be avoided by limiting offtake. PMID:27039527

  16. Ruptured noncommunicating rudimentary horn pregnancy at 19 weeks with previous cesarean delivery: a case report.

    PubMed

    Thakur, Sita; Sood, Ajay; Sharma, Chanderdeep

    2012-01-01

    Unicornuate uterus with noncommunicating rudimentary horn occurs due to incomplete fusion of mullerian ducts. Pregnancy in this horn is a rare phenomenon usually resulting in rupture during second trimester of pregnancy. Prerupture diagnosis of pregnancy in rudimentary horn with ultrasonography is technically difficult, with sensitivity of 30%. We report a case of ruptured non-communicating rudimentary horn at 19 weeks in a woman with previous Cesarean delivery. She had a routine malformation scan in which diagnosis was missed. Later she presented to emergency in shock, with massive hemoperitoneum and ruptured horn. So a high index of suspicion is required to save this catastrophic event and associated maternal morbidity and mortality. In our opinion, routine excision of rudimentary horn should be undertaken during nonpregnant state laparoscopically. However, those women who refuse should be adequately counseled regarding potential complications and if pregnancy occurs in rudimentary horn, first trimester laparoscopic excision should be done. PMID:23119197

  17. Ruptured Noncommunicating Rudimentary Horn Pregnancy at 19 Weeks with Previous Cesarean Delivery: A Case Report

    PubMed Central

    Thakur, Sita; Sood, Ajay; Sharma, Chanderdeep

    2012-01-01

    Unicornuate uterus with noncommunicating rudimentary horn occurs due to incomplete fusion of mullerian ducts. Pregnancy in this horn is a rare phenomenon usually resulting in rupture during second trimester of pregnancy. Prerupture diagnosis of pregnancy in rudimentary horn with ultrasonography is technically difficult, with sensitivity of 30%. We report a case of ruptured non-communicating rudimentary horn at 19 weeks in a woman with previous Cesarean delivery. She had a routine malformation scan in which diagnosis was missed. Later she presented to emergency in shock, with massive hemoperitoneum and ruptured horn. So a high index of suspicion is required to save this catastrophic event and associated maternal morbidity and mortality. In our opinion, routine excision of rudimentary horn should be undertaken during nonpregnant state laparoscopically. However, those women who refuse should be adequately counseled regarding potential complications and if pregnancy occurs in rudimentary horn, first trimester laparoscopic excision should be done. PMID:23119197

  18. Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging

    SciTech Connect

    Wolff, Horst; Hadian, Kamyar; Ziegler, Manja; Weierich, Claudia; Kramer-Hammerle, Susanne; Kleinschmidt, Andrea; Erfle, Volker; Brack-Werner, Ruth . E-mail: brack@gsf.de

    2006-02-15

    The human immunodeficiency virus Rev protein is a post-transcriptional activator of HIV gene expression. Rev is a nucleocytoplasmic shuttle protein that displays characteristic nuclear/nucleolar subcellular localization in various cell lines. Cytoplasmic localization of Rev occurs under various conditions disrupting Rev function. The goal of this study was to investigate the relationship between localization of Rev and its functional activity in living cells. A triple-fluorescent imaging assay, called AQ-FIND, was established for automatic quantitative evaluation of nucleocytoplasmic distribution of fluorescently tagged proteins. This assay was used to screen 500 rev genes generated by error-prone PCR for Rev mutants with different localization phenotypes. Activities of the Rev mutants were determined with a second quantitative, dual-fluorescent reporter assay. In HeLa cells, the majority of nuclear Rev mutants had activities similar to wild-type Rev. The activities of Rev mutants with abnormal cytoplasmic localization ranged from moderately impaired to nonfunctional. There was no linear correlation between subcellular distribution and levels of Rev activity. In astrocytes, nuclear Rev mutants showed similar impaired activities as the cytoplasmic wild-type Rev. Our data suggest that steady-state subcellular localization is not a primary regulator of Rev activity but may change as a secondary consequence of altered Rev function. The methodologies described here have potential for studying the significance of subcellular localization for functions of other regulatory factors.

  19. Micro-Horn Arrays for Ultrasonic Impedance Matching

    NASA Technical Reports Server (NTRS)

    Rao, Shanti; Palmer, Dean

    2009-01-01

    Thin-layered structures containing arrays of micromachined horns, denoted solid micro-horn arrays (SMIHAs), have been conceived as improved means of matching acoustic impedances between ultrasonic transducers and the media with which the transducers are required to exchange acoustic energy. Typically, ultrasonic transducers (e.g., those used in medical imaging) are piezoelectric or similar devices, which produce small displacements at large stresses. However, larger displacements at smaller stresses are required in the target media (e.g., human tissues) with which acoustic energy is to be exchanged. Heretofore, efficiencies in transmission of acoustic energy between ultrasonic transducers and target media have been severely limited because substantial mismatches of acoustic impedances have remained, even when coupling material layers have been interposed between the transducers and the target media. In contrast, SMIHAs can, in principle, be designed to effect more nearly complete acoustic impedance matching, leading to power transmission efficiencies of 90 percent or even greater. The SMIHA concept is based on extension, into the higher-frequency/ lower-wavelength ultrasonic range, of the use of horns to match acoustic impedances in the audible and lower-frequency ultrasonic ranges. In matching acoustic impedance in transmission from a higher-impedance acoustic source (e.g., a piezoelectric transducer) and a lowerimpedance target medium (e.g., air or human tissue), a horn acts as a mechanical amplifier. The shape and size of the horn can be optimized for matching acoustic impedance in a specified frequency range. A typical SMIHA would consist of a base plate, a face plate, and an array of horns that would constitute pillars that connect the two plates (see figure). In use, the base plate would be connected to an ultrasonic transducer and the face plate would be placed in contact with the target medium. As at lower frequencies, the sizes and shapes of the pillars

  20. Potential threats to offshore platforms

    SciTech Connect

    Jenkins, B.M.

    1988-01-01

    Increasingly spectacular acts of terrorism have led to growing concern that terrorists will move beyond the symbols of society and directly attack its technological and industrial vulnerabilities. Offshore platforms have been frequently mentioned among the potential targets terrorists might attack. This concern, however, has not resulted in extensive research like that devoted to possible threats to nuclear facilities, which have also been frequently mentioned as possible future targets of terrorists. For one thing, offshore drilling does not invoke the fear inherent in the word nuclear, a fear that translates directly into heavy security for the nuclear industry. Neither does the construction of offshore platforms provoke anything like the kind of protest generated by the construction of nuclear facilities.

  1. Biallelic inactivation of REV7 is associated with Fanconi anemia.

    PubMed

    Bluteau, Dominique; Masliah-Planchon, Julien; Clairmont, Connor; Rousseau, Alix; Ceccaldi, Raphael; Dubois d'Enghien, Catherine; Bluteau, Olivier; Cuccuini, Wendy; Gachet, Stéphanie; Peffault de Latour, Régis; Leblanc, Thierry; Socié, Gérard; Baruchel, André; Stoppa-Lyonnet, Dominique; D'Andrea, Alan D; Soulier, Jean

    2016-09-01

    Fanconi anemia (FA) is a recessive genetic disease characterized by congenital abnormalities, chromosome instability, progressive bone marrow failure (BMF), and a strong predisposition to cancer. Twenty FA genes have been identified, and the FANC proteins they encode cooperate in a common pathway that regulates DNA crosslink repair and replication fork stability. We identified a child with severe BMF who harbored biallelic inactivating mutations of the translesion DNA synthesis (TLS) gene REV7 (also known as MAD2L2), which encodes the mutant REV7 protein REV7-V85E. Patient-derived cells demonstrated an extended FA phenotype, which included increased chromosome breaks and G2/M accumulation upon exposure to DNA crosslinking agents, γH2AX and 53BP1 foci accumulation, and enhanced p53/p21 activation relative to cells derived from healthy patients. Expression of WT REV7 restored normal cellular and functional phenotypes in the patient's cells, and CRISPR/Cas9 inactivation of REV7 in a non-FA human cell line produced an FA phenotype. Finally, silencing Rev7 in primary hematopoietic cells impaired progenitor function, suggesting that the DNA repair defect underlies the development of BMF in FA. Taken together, our genetic and functional analyses identified REV7 as a previously undescribed FA gene, which we term FANCV. PMID:27500492

  2. Suppression of atherosclerosis by synthetic REV-ERB agonist.

    PubMed

    Sitaula, Sadichha; Billon, Cyrielle; Kamenecka, Theodore M; Solt, Laura A; Burris, Thomas P

    2015-05-01

    The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agonists that we have developed might have the ability to suppress atherosclerosis in this model. A previously characterized synthetic REV-ERB agonist, SR9009, was used to determine if activation of REV-ERB activity would affect atherosclerosis in LDL receptor deficient mice. Atherosclerotic plaque size was significantly reduced (p < 0.05) in mice administered SR9009 (100 mg/kg) for seven weeks compared to control mice (n = 10 per group). SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to proinflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages. Our results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for treatment of atherosclerosis. PMID:25800870

  3. Attached cavitation at a small diameter ultrasonic horn tip

    NASA Astrophysics Data System (ADS)

    Žnidarčič, Anton; Mettin, Robert; Cairós, Carlos; Dular, Matevž

    2014-02-01

    Ultrasonic horn transducers are frequently used in applications of acoustic cavitation in liquids, for instance, for cell disruption or sonochemical reactions. They are operated typically in the frequency range up to about 50 kHz and have tip diameters from some mm to several cm. It has been observed that if the horn tip is sufficiently small and driven at high amplitude, cavitation is very strong, and the tip can be covered entirely by the gas/vapor phase for longer time intervals. A peculiar dynamics of the attached cavity can emerge with expansion and collapse at a self-generated frequency in the subharmonic range, i.e., below the acoustic driving frequency. Here, we present a systematic study of the cavitation dynamics in water at a 20 kHz horn tip of 3 mm diameter. The system was investigated by high-speed imaging with simultaneous recording of the acoustic emissions. Measurements were performed under variation of acoustic power, air saturation, viscosity, surface tension, and temperature of the liquid. Our findings show that the liquid properties play no significant role in the dynamics of the attached cavitation at the small ultrasonic horn. Also the variation of the experimental geometry, within a certain range, did not change the dynamics. We believe that the main two reasons for the peculiar dynamics of cavitation on a small ultrasonic horn are the higher energy density on a small tip and the inability of the big tip to "wash" away the gaseous bubbles. Calculation of the somewhat adapted Strouhal number revealed that, similar to the hydrodynamic cavitation, values which are relatively low characterize slow cavitation structure dynamics. In cases where the cavitation follows the driving frequency this value lies much higher - probably at Str > 20. In the spirit to distinguish the observed phenomenon with other cavitation dynamics at ultrasonic transducer surfaces, we suggest to term the observed phenomenon of attached cavities partly covering the full horn

  4. Offshore Energy Knowledge Exchange Workshop Report

    SciTech Connect

    none,

    2012-04-12

    A report detailing the presentations and topics discussed at the Offshore Energy Knowledge Exchange Workshop, an event designed to bring together offshore energy industry representatives to share information, best practices, and lessons learned.

  5. Climate and offshore energy resources

    NASA Astrophysics Data System (ADS)

    Twitchell, P. F.

    1980-12-01

    A conference discussed the relationship of climate to the world's offshore energy resources. The conference focused upon such areas as the impact of oil resources upon the economies of developed and developing countries, the importance of providing climatic data in sufficient time to meet users' needs, and the hazards and financial burdens associated with the development of offshore oil reserves. One of the important achievements of the confidence was the establishment of better communications between the users of environmental data and those charged with producing predictions.

  6. Eighteenth annual offshore technology conference. Volume 1

    SciTech Connect

    Not Available

    1986-01-01

    These sixty papers were given at a conference on offshore technology. Topics covered include friction effects of driving piles into sea beds of various compositions, wave forces on offshore platforms, stability, materials testing of various components such as plates, legs, wellheads, pipe joints, and protection of offshore platforms against ice and collision with icebergs.

  7. Clauser-Horne Bell test with imperfect random inputs

    NASA Astrophysics Data System (ADS)

    Yuan, Xiao; Zhao, Qi; Ma, Xiongfeng

    2015-08-01

    The Bell test is one of the most important tools in quantum information science. On the one hand, it enables fundamental tests of the basic physics laws of nature, and on the other hand, it can also be applied in a variety of device-independent tasks such as quantum key distribution and random number generation. In practice, loopholes existing in experimental demonstrations of Bell tests may affect the validity of the conclusions. In this work, we focus on the randomness (freewill) loophole and investigate the randomness requirement in a well-known Bell test, the Clauser-Horne test, under various conditions. We explicitly bound the Bell value for all local hidden variable models by optimizing over all classical strategies exploiting the knowledge of the partially random inputs. Our result thus provides input randomness requirements on the Clauser-Horne test under varieties of practical scenarios. The employed analysis technique can also be generalized to other Bell inequalities.

  8. Investigation of noninertial cavitation produced by an ultrasonic horn.

    PubMed

    Birkin, Peter R; Offin, Douglas G; Vian, Christopher J B; Leighton, Timothy G; Maksimov, Alexey O

    2011-11-01

    This paper reports on noninertial cavitation that occurs beyond the zone close to the horn tip to which the inertial cavitation is confined. The noninertial cavitation is characterized by collating the data from a range of measurements of bubbles trapped on a solid surface in this noninertial zone. Specifically, the electrochemical measurement of mass transfer to an electrode is compared with high-speed video of the bubble oscillation. This gas bubble is shown to be a "noninertial" event by electrochemical surface erosion measurements and "ring-down" experiments showing the activity and motion of the bubble as the sound excitation was terminated. These measurements enable characterization of the complex environment produced below an operating ultrasonic horn outside of the region where inertial collapse can be detected. The extent to which solid boundaries in the liquid cause the frequencies and shapes of oscillatory modes on the bubble wall to differ from their free field values is discussed. PMID:22088002

  9. Simplified horn antenna parameter estimation using selective criteria

    SciTech Connect

    Ewing, P.D.

    1991-01-01

    An approximation can be used to avoid the complex mathematics and computation methods typically required for calculating the gain and radiation pattern of electromagnetic horn antenna. Because of the curvature of the antenna wave front, calculations using conventional techniques involve solving the Fresnel integrals and using computer-aided numerical integration. With this model, linear approximations give a reasonable estimate of the gain and radiation pattern using simple trigonometric functions, thereby allowing a hand calculator to replace the computer. Applying selected criteria, the case of the E-plane horn antenna was used to evaluate this technique. Results showed that the gain approximation holds for an antenna flare angle of less than 10{degree} for typical antenna dimensions, and the E field radiation pattern approximation holds until the antenna's phase error approaches 60{degree}, both within typical design parameters. This technique is a useful engineering tool. 4 refs., 11 figs.

  10. Novel Features of the Prenatal Horn Bud Development in Cattle (Bos taurus)

    PubMed Central

    Wiener, Dominique Judith; Wiedemar, Natalie; Welle, Monika Maria; Drögemüller, Cord

    2015-01-01

    Whereas the genetic background of horn growth in cattle has been studied extensively, little is known about the morphological changes in the developing fetal horn bud. In this study we histologically analyzed the development of horn buds of bovine fetuses between ~70 and ~268 days of pregnancy and compared them with biopsies taken from the frontal skin of the same fetuses. In addition we compared the samples from the wild type (horned) fetuses with samples taken from the horn bud region of age-matched genetically hornless (polled) fetuses. In summary, the horn bud with multiple layers of vacuolated keratinocytes is histologically visible early in fetal life already at around day 70 of gestation and can be easily differentiated from the much thinner epidermis of the frontal skin. However, at the gestation day (gd) 212 the epidermis above the horn bud shows a similar morphology to the epidermis of the frontal skin and the outstanding layers of vacuolated keratinocytes have disappeared. Immature hair follicles are seen in the frontal skin at gd 115 whereas hair follicles below the horn bud are not present until gd 155. Interestingly, thick nerve bundles appear in the dermis below the horn bud at gd 115. These nerve fibers grow in size over time and are prominent shortly before birth. Prominent nerve bundles are not present in the frontal skin of wild type or in polled fetuses at any time, indicating that the horn bud is a very sensitive area. The samples from the horn bud region from polled fetuses are histologically equivalent to samples taken from the frontal skin in horned species. This is the first study that presents unique histological data on bovine prenatal horn bud differentiation at different developmental stages which creates knowledge for a better understanding of recent molecular findings. PMID:25993643

  11. Gene discovery in the horned beetle Onthophagus taurus

    PubMed Central

    2010-01-01

    Background Horned beetles, in particular in the genus Onthophagus, are important models for studies on sexual selection, biological radiations, the origin of novel traits, developmental plasticity, biocontrol, conservation, and forensic biology. Despite their growing prominence as models for studying both basic and applied questions in biology, little genomic or transcriptomic data are available for this genus. We used massively parallel pyrosequencing (Roche 454-FLX platform) to produce a comprehensive EST dataset for the horned beetle Onthophagus taurus. To maximize sequence diversity, we pooled RNA extracted from a normalized library encompassing diverse developmental stages and both sexes. Results We used 454 pyrosequencing to sequence ESTs from all post-embryonic stages of O. taurus. Approximately 1.36 million reads assembled into 50,080 non-redundant sequences encompassing a total of 26.5 Mbp. The non-redundant sequences match over half of the genes in Tribolium castaneum, the most closely related species with a sequenced genome. Analyses of Gene Ontology annotations and biochemical pathways indicate that the O. taurus sequences reflect a wide and representative sampling of biological functions and biochemical processes. An analysis of sequence polymorphisms revealed that SNP frequency was negatively related to overall expression level and the number of tissue types in which a given gene is expressed. The most variable genes were enriched for a limited number of GO annotations whereas the least variable genes were enriched for a wide range of GO terms directly related to fitness. Conclusions This study provides the first large-scale EST database for horned beetles, a much-needed resource for advancing the study of these organisms. Furthermore, we identified instances of gene duplications and alternative splicing, useful for future study of gene regulation, and a large number of SNP markers that could be used in population-genetic studies of O. taurus and

  12. Ultrasonic Heat Transfer Enhancement Using a Horn-Type Transducer

    NASA Astrophysics Data System (ADS)

    Nomura, Shinfuku; Yamamoto, Akira; Murakami, Koichi

    2002-05-01

    The purpose of this study is to clarify experimentally the influence of streaming induced by ultrasonic vibration on heat transfer using a horn-type ultrasonic vibrator. A horn tip of 6 mm diameter and 60.7 kHz resonant frequency was used as the ultrasonic transducer. Heat transfer experiments for a downward-facing horizontal heating surface with ultrasonic vibration from below were carried out in a natural convection region. The acoustic jet in the water from the horn tip of the transducer regarded as a nozzle exit was induced by this transducer, and as a result, up to a ten-fold increase in heat transfer coefficient was obtained by application of 20 W in both tap water and degassed water. It was found that the mechanism of heat transfer enhancement by ultrasonic vibration in tap water can be classified into four categories. In degassed water, heat transfer enhancement is influenced not by the acoustic jet, but by small-scale perturbations by cavitation microjets.

  13. Correlation of peripheral innervation density and dorsal horn map scale.

    PubMed

    Wang, L; Millecchia, R; Brown, P B

    1997-08-01

    Dorsal horn map scale and peripheral innervation density were compared to test a hypothesized linear relationship. In anesthetized cats, low-threshold mechanoreceptive peripheral nerve innervation fields (IFs) were measured by outlining areas of skin from which action potentials could be elicited in cutaneous nerves. The same nerves were processed histologically and used to count myelinated axons. Innervation density for each nerve was calculated as number of axons divided by IF area. Single units were recorded throughout the hindlimb representation, in laminae III and IV. These data, combined with single-unit data from other animals and with cell counts in laminae III and IV, permitted estimation of numbers of cells whose receptive field centers fell in contiguous 1-cm bands from tips of toes to proximal thigh. A similar estimate was performed with the use of the nerve innervation data, so that peripheral innervation densities and map scales for the different 1-cm bands of skin could be compared. Correlation between the two was quite high (r = 0.8), and highly significant (P = 2.5 x 10(-7)). These results are consistent with a proposed developmental model in which map scale, peripheral innervation density, and reciprocal of dorsal horn cell receptive field size are mutually proportional, as a result of developmental mechanisms that produce constant divergence and convergence between primary afferent axons and dorsal horn cells. PMID:9307105

  14. REV-ERB and ROR nuclear receptors as drug targets

    PubMed Central

    Kojetin, Douglas J.; Burris, Thomas P.

    2016-01-01

    The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are involved in many physiological processes, including regulation of metabolism, development and immunity as well as the circadian rhythm. The recent characterization of endogenous ligands for these former orphan nuclear receptors has stimulated the development of synthetic ligands and opened up the possibility of targeting these receptors to treat several diseases, including diabetes, atherosclerosis, autoimmunity and cancer. This Review focuses on the latest developments in ROR and REV-ERB pharmacology indicating that these nuclear receptors are druggable targets and that ligands targeting these receptors may be useful in the treatment of several disorders. PMID:24577401

  15. Foundations for offshore wind turbines.

    PubMed

    Byrne, B W; Houlsby, G T

    2003-12-15

    An important engineering challenge of today, and a vital one for the future, is to develop and harvest alternative sources of energy. This is a firm priority in the UK, with the government setting a target of 10% of electricity from renewable sources by 2010. A component central to this commitment will be to harvest electrical power from the vast energy reserves offshore, through wind turbines or current or wave power generators. The most mature of these technologies is that of wind, as much technology transfer can be gained from onshore experience. Onshore wind farms, although supplying 'green energy', tend to provoke some objections on aesthetic grounds. These objections can be countered by locating the turbines offshore, where it will also be possible to install larger capacity turbines, thus maximizing the potential of each wind farm location. This paper explores some civil-engineering problems encountered for offshore wind turbines. A critical component is the connection of the structure to the ground, and in particular how the load applied to the structure is transferred safely to the surrounding soil. We review previous work on the design of offshore foundations, and then present some simple design calculations for sizing foundations and structures appropriate to the wind-turbine problem. We examine the deficiencies in the current design approaches, and the research currently under way to overcome these deficiencies. Designs must be improved so that these alternative energy sources can compete economically with traditional energy suppliers. PMID:14667305

  16. National Offshore Wind Energy Grid Interconnection Study

    SciTech Connect

    Daniel, John P.; Liu, Shu; Ibanez, Eduardo; Pennock, Ken; Reed, Greg; Hanes, Spencer

    2014-07-30

    The National Offshore Wind Energy Grid Interconnection Study (NOWEGIS) considers the availability and potential impacts of interconnecting large amounts of offshore wind energy into the transmission system of the lower 48 contiguous United States. A total of 54GW of offshore wind was assumed to be the target for the analyses conducted. A variety of issues are considered including: the anticipated staging of offshore wind; the offshore wind resource availability; offshore wind energy power production profiles; offshore wind variability; present and potential technologies for collection and delivery of offshore wind energy to the onshore grid; potential impacts to existing utility systems most likely to receive large amounts of offshore wind; and regulatory influences on offshore wind development. The technologies considered the reliability of various high-voltage ac (HVAC) and high-voltage dc (HVDC) technology options and configurations. The utility system impacts of GW-scale integration of offshore wind are considered from an operational steady-state perspective and from a regional and national production cost perspective.

  17. Millimeter-wave integrated-horn antennas. I - Theory. II - Experiment

    NASA Technical Reports Server (NTRS)

    Eleftheriades, George V.; Ali-Ahmad, Walid Y.; Katehi, Linda P. B.; Rebeiz, Gabriel M.

    1991-01-01

    Full-wave analysis is employed to determine the far-field pattern and input impedance of a dipole-fed horn antenna in a ground plane, and the theoretical results are compared with mm-wave and microwave data. The theoretical work exploits the Green's function corresponding to the horn structure and the method of moments. It is determined that the horn should have 70 sections/wavelength and 50 secondary modes for optimized accuracy, and certain dipole positions can reduce the resonance to zero. The experimentally derived impedance and radiation patterns agree with the constraints developed theoretically. The 70-degree flare-angle horn with selected dipole positions and horn apertures yields good radiation patterns, cross-polarization levels, and resonant dipole impedances. The conclusions are of interest to the development of the horn antennas etched in Si/GaAs for applications to zero-visibility tracking, radio astronomy, plasma diagnostics, and remote sensing.

  18. Midtrimester spontaneous torsion of unruptured gravid rudimentary horn: Presurgical diagnosis on magnetic resonance imaging.

    PubMed

    Singh, Pragya; Gupta, Rohini; Das, Banashree; Bajaj, Sunil Kumar; Misra, Ritu

    2015-09-01

    Unicornuate uterus with rudimentary horn occurs due to failure of complete development and partial fusion of one of the Müllerian ducts. Pregnancy in a non-communicating rudimentary horn is extremely rare, with a reported incidence of 1 in 76 000-150 000 pregnancies, and usually terminates in rupture during the first or second trimester. Clinical diagnosis of rudimentary horn pregnancy in a woman with history of normal vaginal delivery in prior gestations is difficult. The role of sonography, and more recently, magnetic resonance imaging, in the presurgical diagnosis of rudimentary horn pregnancy is established. We present a case of magnetic resonance imaging diagnosis of 20-week pregnancy in the unruptured non-communicating rudimentary horn in a patient with previous history of two full-term normal vaginal deliveries. The novelty of the case lies in the fact that there was associated torsion of the gravid rudimentary horn and ipsilateral ovary, which has not been reported previously. PMID:26013913

  19. Rare case of live birth in a ruptured rudimentary horn pregnancy.

    PubMed

    Kawthalkar, Anjali S; Gawande, Madhuri S; Jain, Sheela H; Joshi, Sulabha A; Ghike, Sunita D; Bhalerao, Anuja V

    2011-08-01

    Pregnancy in the rudimentary horn is a very rare condition. In these cases, rupture of the rudimentary horn in the second trimester with fetal death and catastrophic intraperitoneal hemorrhage is the commonly reported outcome. Silent rupture of the rudimentary horn and continuation of pregnancy as a secondary abdominal pregnancy is the most unusual outcome of this rare condition. We report such a case with a good maternal and neonatal outcome. The case is being reported for its rarity. PMID:21501332

  20. Sonographic diagnosis of uncomplicated first-trimester pregnancy in the rudimentary horn of a unicornuate uterus.

    PubMed

    Taori, Kishor; Saha, Bimal Kumar; Shah, Deepal; Khadaria, Narottam; Jadhav, Vijay; Jawale, Rajesh

    2008-01-01

    Although pregnancy in a rudimentary uterine horn is rare, the correct diagnosis of this condition on routine sonographic examination is critical, because its natural history usually involves the rupture of the pregnant horn during the second or third trimester, resulting in life-threatening bleeding. We report a case in which the diagnosis of right unicornuate uterus with a left noncommunicating rudimentary horn was made in the first trimester on routine sonographic examination. PMID:17410585

  1. Pregnancy in a noncommunicating rudimentary horn of a unicornuate uterus: a case report.

    PubMed

    Okonta, Patrick I; Abedi, Harrison; Ajuyah, Caroline; Omo-Aghoja, Lawrence

    2009-01-01

    Pregnancy in the rudimentary horn is rare and carries grave consequences for the mother and fetus. A case report is presented of a 26 year old single gravida 3 para 0(+2) lady with rupture of a rudimentary horn pregnancy at a gestational age of 20 weeks. Laparotomy was done and the rudimentary horn excised. Post-operative recovery was uneventful. The need for a high index of suspicion and the role of ultrasonography in the accurate diagnosis is highlighted. PMID:19829836

  2. Laparoscopic excision of rudimentary horn pregnancy in a patient with previous caesarean section.

    PubMed

    Jihong, Lu; Siow, Anthony; Chern, Bernard

    2009-03-01

    A rudimentary uterine horn is extremely rare and often difficult to diagnose. The frequency of this pathology is approximately 1:100,000. The diagnosis is sometimes elusive even at surgery. We present a case report of pregnancy in a rudimentary horn in the patient with one caesarean and one normal vaginal delivery, and we successfully conduct a removal of the rudimentary horn pregnancy laparoscopically. PMID:18629528

  3. [Uterine rupture plugged by omentum in a rudimentary horn pregnancy: About a rare case].

    PubMed

    Le Mitouard, M; Huissoud, C; Fichez, A; Roumieu, F; Allias, F; Rudigoz, R C; Caloone, J

    2016-05-01

    Pregnancy in a rudimentary horn of a pseudo-horned uterus is a rare obstetrical situation, for which, maternal-fetal prognosis is altered by the risk of uterine rupture. We report a rare case of pregnancy in a rudimentary horn with birth of a living child at 28 weeks of amenorrhea. During caesarean, uterine rupture plugged by the omentum was observed. We discuss from this case obstetric management of this pathology. PMID:27021927

  4. Studies on thermo-elastic heating of horns used in ultrasonic plastic welding.

    PubMed

    Roopa Rani, M; Prakasan, K; Rudramoorthy, R

    2015-01-01

    Ultrasonic welding horn is half wavelength section or tool used to focus the ultrasonic vibrations to the components being welded. The horn is designed in such a way that it maximizes the amplitude of the sound wave passing through it. The ends of the horn represent the displacement anti-nodes and the center the 'node' of the wave. As the horns perform 20,000 cycles of expansion and contraction per second, they are highly stressed at the nodes and are heated owing to thermo-elastic effects. Considerable temperature rise may be observed in the horn, at the nodal region when working at high amplitudes indicating high stress levels leading to failure of horns due to cyclic loading. The limits for amplitude must therefore be evaluated for the safe working of the horn. Horns made of different materials have different thermo-elastic behaviors and hence different temperatures at the nodes and antinodes. This temperature field can be used as a control mechanism for setting the amplitude/weld parameters. Safe stress levels can be predicted using modal and harmonic analyses followed by a stress analysis to study the effect of cyclic loads. These are achieved using 'Ansys'. The maximum amplitude level obtained from the stress analysis is used as input for 'Comsol' to predict the temperature field. The actual temperature developed in the horn during operation is measured using infrared camera and compared with the simulated temperature. From experiments, it is observed that horn made of titanium had the lowest temperature rise at the critical region and can be expected to operate at amplitudes up to 77 μm without suffering failure due to cyclic loading. The method of predicting thermo-elastic stresses and temperature may be adopted by the industry for operating the horn within the safe stress limits thereby extending the life of the horn. PMID:25087474

  5. Multiple flare-angle horn feeds for sub-mm astronomy and cosmic microwave background experiments

    NASA Astrophysics Data System (ADS)

    Leech, J.; Tan, B. K.; Yassin, G.; Kittara, P.; Wangsuya, S.; Treuttel, J.; Henry, M.; Oldfield, M. L.; Huggard, P. G.

    2011-08-01

    Context. The use of large-format focal plane imaging arrays employing multiple feed horns is becoming increasingly important for the next generation of single dish sub-mm telescopes and cosmology experiments. Such receivers are being commissioned on both general purpose, common user telescopes and telescopes specifically designed for mapping intensity and polarisation anisotropies in the cosmic microwave background (CMB). Telescopes are currently being constructed to map the CMB polarisation that employ hundreds of feeds and the cost of manufacturing these feeds has become a significant fraction of the total cost of the telescope. Aims: We have developed and manufactured low-cost easy-to-machine smooth-walled horns that have a performance comparable to the more traditional corrugated feed horns that are often used in focal plane arrays. Our horns are much easier to fabricate than corrugated horns enabling the rapid construction of arrays with a large number of horns at a very low cost. Methods: Our smooth walled horns use multiple changes in flare angle to excite higher order waveguide modes. They are designed using a genetic algorithm to optimise the positions and magnitudes of these flare angle discontinuities. We have developed a fully parallelised software suite for the optimisation of these horns. We have manufactured prototype horns by traditional electroforming and also by a new direct drilling technique and we have measured their beam patterns using a far-field antenna test range at 230 GHz. Results: We present simulated and measured far-field beam patterns for one of our horn designs. They exhibit low sidelobe levels, good beam circularity and low cross-polarisation levels over a fractional bandwidth of 20%. These results offer experimental confirmation of our design technique, allowing us to proceed confidently in the optimisation of horns with a wider operational bandwidth. The results also show that the new manufacturing technique using drilling is

  6. Spatial convergence and divergence between cutaneous afferent axons and dorsal horn cells are not constant.

    PubMed

    Brown, P B; Harton, P; Millecchia, R; Lawson, J; Kunjara-Na-Ayudhya, T; Stephens, S; Miller, M A; Hicks, L; Culberson, J

    2000-05-01

    We have proposed a quantitative model of the development of dorsal horn cell receptive fields (RFs) and somatotopic organization (Brown et al. [1997] Somatosens. Motor Res. 14:93-106). One component of that model is a hypothesis that convergence and divergence of connections between low-threshold primary afferent mechanoreceptive axons and dorsal horn cells are invariant over skin location and dorsal horn location. The more limited, and more easily tested, hypothesis that spatial convergence and divergence between cutaneous mechanoreceptors and dorsal horn cell are constant was examined. Spatial divergence is the number of dorsal horn cells whose RFs overlap the RF center of a primary afferent, and spatial convergence is the number of afferent RF centers that lie within the RF of a dorsal horn cell. Innervation density was determined as a function of location on the hindlimb by using peripheral nerve recording and axon counting. A descriptive model of dorsal horn cell receptive fields (Brown et al. [1998] J. Neurophysiol. 31:833-848) was used to simulate RFs of the entire dorsal horn cell population in order to estimate RF area and map scale as a function of location on the hindlimb. Previously reported correlations among innervation density, map scale, and RF size were confirmed. However, these correlations were not linear. The hypothesis that spatial convergence and divergence are constant was rejected. The previously proposed model of development of dorsal horn cell somatotopy and RF geometries must be revised to take variable spatial convergence and divergence into account. PMID:10754502

  7. Transcription profiling provides insights into gene pathways involved in horn and scurs development in cattle

    PubMed Central

    2010-01-01

    Background Two types of horns are evident in cattle - fixed horns attached to the skull and a variation called scurs, which refers to small loosely attached horns. Cattle lacking horns are referred to as polled. Although both the Poll and Scurs loci have been mapped to BTA1 and 19 respectively, the underlying genetic basis of these phenotypes is unknown, and so far, no candidate genes regulating these developmental processes have been described. This study is the first reported attempt at transcript profiling to identify genes and pathways contributing to horn and scurs development in Brahman cattle, relative to polled counterparts. Results Expression patterns in polled, horned and scurs tissues were obtained using the Agilent 44 k bovine array. The most notable feature when comparing transcriptional profiles of developing horn tissues against polled was the down regulation of genes coding for elements of the cadherin junction as well as those involved in epidermal development. We hypothesize this as a key event involved in keratinocyte migration and subsequent horn development. In the polled-scurs comparison, the most prevalent differentially expressed transcripts code for genes involved in extracellular matrix remodelling, which were up regulated in scurs tissues relative to polled. Conclusion For this first time we describe networks of genes involved in horn and scurs development. Interestingly, we did not observe differential expression in any of the genes present on the fine mapped region of BTA1 known to contain the Poll locus. PMID:20537189

  8. Ruptured rudimentary horn pregnancy with a history of an uneventful vaginal delivery.

    PubMed

    Mishra, Nitin; Yadav, Nitin; Koshiya, Darshan; Jhanwar, Vikas

    2015-01-01

    Pregnancy in a rudimentary uterine horn is a rare event with an estimated incidence of 1 in 76,000 to 1 in 1,40,000 pregnancies. Unicornuate uterus with a rudimentary horn has a high incidence of obstetric and gynecological complications. Ruptured ectopic pregnancy in the rudimentary horn is one of the most dreaded complications, which can have grave consequences for both mother and fetus. In the majority of the cases, it is detected after rupture of the horn, usually during the first or second trimester of pregnancy. An ultrasonographic diagnosis made prior to rupture of the rudimentary horn may prevent this catastrophic outcome. We report a case of a G2 P1 L1 with a ruptured left rudimentary horn pregnancy at 16 weeks of gestation that was misdiagnosed as a pregnancy in the left uterine horn of a bicornuate uterus on prior prenatal ultrasound. The patient presented to our hospital with abdominal pain and vaginal bleeding. A diagnosis of ruptured left rudimentary horn pregnancy was made on the basis of emergency ultrasound and was later confirmed on laparotomy. The left rudimentary horn along with the ipsilateral fallopian tube was excised. PMID:26578500

  9. Novel horn designs for ultrasonic/sonic cleaning, welding, soldering, cutting, and drilling

    NASA Astrophysics Data System (ADS)

    Sherrit, Stewart; Askins, Steven A.; Gradziol, Mike; Dolgin, Benjamin P.; Bao, Xiaoqi; Chang, Zensheu; Bar-Cohen, Yoseph

    2002-07-01

    A variety of Industrial applications exist where power ultrasonic elements such as the ultrasonic horn are used. These included the Automotive, Instruments, Foods, Medical, Textiles and Material Joining and Fabrication Industries. In many of these devices the ultrasonic horn is the key component. The standard transducer used in these devices consists of three main parts, the backing, the piezoelectric elements and the horn. Standard horn designs have changed very little since their inception. There are four common types of standard horns. They are; constant, linear, exponential and stepped, which refer to the degree to which the area changes from the base to the tip. A magnification in the strain occurs in the horn that in general is a function of the ratio of diameters. In addition the device is generally driven at resonance to further amplify the strain. The resonance amplification is in general determined by the mechanical Q (attenuation) of the horn material and radiation damping. The horn length primarily determines the resonance frequency. For a 22 kHz resonance frequency a stepped horn of titanium has a length of approximately 8 cm. Although these standard horns are found in many current industrial designs they suffer from some key limitations. In many applications it would be useful to reduce the resonance frequency however this would require device lengths of the order of fractions of meters which may be impractical. In addition, manufacturing a horn requires the turning down of the stock material (eg. Titanium) from the larger outer diameter to the horn tip diameter, which is both time consuming and wasteful. In this paper we will present a variety of novel horn designs, which overcome some of the limitations discussed above. One particular design that has been found to overcome these limitations is the folded horn. In this design the horn elements are folded which reduce the overall length of the resonator (physical length) but maintain or increase the

  10. Computation of reflected and transmitted horn radiation patterns for a dichroic plate

    NASA Technical Reports Server (NTRS)

    Chen, J. C.

    1994-01-01

    A previous dichroic plate analysis has assumed that an ideal uniform plane wave illuminates the dichroic plate at a single angle of incidence. In fact, a horn radiates energy at the dichroic plate and illuminates it at many different angles. To model the horn and dichroic plate system, the horn pattern is represented as a group of plane waves traveling in different directions. The details of this analysis are presented this article. The calculated and measured reflected radiation patterns show good agreement. The noise temperature predicted from the horn pattern model is shown to be more accurate than that from a simple plane-wave model.

  11. Fatigue handbook: Offshore steel structures

    SciTech Connect

    Almarnaess, A.

    1985-01-01

    The contents of this book are: Overview of Offshore Steel Structures; Loads on Ocean Structures; Fracture Mechanics As a Tool in Fatigue Analysis; Basic Fatigue Properties of Welded Joints; Significance of Defects; Improving the Fatigue Strength of Welded Joints; Effects of Marine Environment and Cathodic Protection on Fatigue of Structural Steels Fatigue of Tubular Joints; Unstable Fracture; Fatigue Life Calculations; and Fatigue in Building Codes Background and Applications.

  12. Offshore sand and gravel mining

    SciTech Connect

    Pandan, J.W.

    1983-05-01

    This paper reviews the status of mining offshore for sand and gravel on a world-wide basis. It discusses the technology for exploration and evaluation of sea floor mineral targets, as well as mining, transportation, and processing. Large operations in Japan and Europe are described, based upon personal observations of the author. The U.S. situation is outlined and opinions offered as to the outlook for the future.

  13. Pipelaying in artic offshore waters

    SciTech Connect

    Langner, C. G.

    1985-11-19

    The present invention provides a method and apparatus for constructing pipelines in Arctic offshore waters by a directional drilling technique, thereby minimizing exposure to ice gouging and eliminating the hazards associated with unstable permafrost. A special drilling-pipe-line construction vessel is also provided which has a conical shape with reinforced outer walls to resist ice forces, which vessel includes means to install deep underground pipeline segments and means to connect and protect the pipe ends.

  14. Two offshore Australian crudes assayed

    SciTech Connect

    Rhodes, A.K.

    1994-05-09

    Two light, sweet crudes from offshore Australia have been assayed. Gippsland crude, also called Bass Strait, is produced off the coast of Victoria, in southeastern Australia. The 47 API, 0.09% sulfur crude was analyzed in mid-1993. Skua, a 42 API, 0.06 wt % sulfur crude, is produced in the Timor Sea. Data are given on the whole crude and fractions for both deposits. Both chemical and physical properties are listed.

  15. Offshore oil: Correctness of perspective

    SciTech Connect

    Burns, R.F.

    1993-05-01

    Except for the Gulf of Mexico, the offshore oil industry has been virtually banned from the US Exclusive Economic Zone for ten years. The oil potential in Alaska's Arctic National Wildlife Refuge (ANWR) is also off limits. The Gulf of Mexico is the only place with prospects for future success and a number of companies both large and small are determined to move forward. The depressed price of oil does not encourage development but recently gas prices in the US have increased, making offshore gas development more feasible. Perhaps most significant is development and application of new technology and more intense management to make sure it works. The offshore oil companies and support industries have made significant technological advances, expending over and above the dollars paid in taxes, lease fees, and royalties. The ocean industries harbor a great reservoir of high technology knowledge. They have demonstrated the ability to successfully meet a vast array of challenges in exploring for, drilling, and producing oil and gas in extreme conditions. These facts beg the question as to the rational basis of each and every regulation and the ban on drilling.

  16. Molar enamel thickness and dentine horn height in Gigantopithecus blacki.

    PubMed

    Olejniczak, A J; Smith, T M; Wang, W; Potts, R; Ciochon, R; Kullmer, O; Schrenk, F; Hublin, J-J

    2008-01-01

    Absolutely thick molar enamel is consistent with large body size estimates and dietary inferences about Gigantopithecus blacki, which focus on tough or fibrous vegetation. In this study, 10 G. blacki molars demonstrating various stages of attrition were imaged using high-resolution microtomography. Three-dimensional average enamel thickness and relative enamel thickness measurements were recorded on the least worn molars within the sample (n = 2). Seven molars were also virtually sectioned through the mesial cusps and two-dimensional enamel thickness and dentine horn height measurements were recorded. Gigantopithecus has the thickest enamel of any fossil or extant primate in terms of absolute thickness. Relative (size-scaled) measures of enamel thickness, however, support a thick characterization (i.e., not "hyper-thick"); G. blacki relative enamel thickness overlaps slightly with Pongo and completely with Homo. Gigantopithecus blacki dentine horns are relatively short, similar to (but shorter than) those of Pongo, which in turn are shorter than those of humans and African apes. Gigantopithecus blacki molar enamel (and to a lesser extent, that of Pongo pygmaeus) is distributed relatively evenly across the occlusal surface compared with the more complex distribution of enamel thickness in Homo sapiens. The combination of evenly distributed occlusal enamel and relatively short dentine horns in G. blacki results in a flat and low-cusped occlusal surface suitable to grinding tough or fibrous food objects. This suite of molar morphologies is also found to varying degrees in Pongo and Sivapithecus, but not in African apes and humans, and may be diagnostic of subfamily Ponginae. PMID:17941103

  17. Dorsal horn spatial representation of simple cutaneous stimuli.

    PubMed

    Brown, P B; Millecchia, R; Lawson, J J; Stephens, S; Harton, P; Culberson, J C

    1998-02-01

    A model of lamina III-IV dorsal horn cell receptive fields (RFs) has been developed to visualize the spatial patterns of cells activated by light touch stimuli. Low-threshold mechanoreceptive fields (RFs) of 551 dorsal horn neurons recorded in anesthetized cats were characterized by location of RF center in cylindrical coordinates, area, length/width ratio, and orientation of long axis. Best-fitting ellipses overlapped actual RFs by 90%. Exponentially smoothed mean and variance surfaces were estimated for these five variables, on a grid of 40 points mediolaterally by 20/segment rostrocaudally in dorsal horn segments L4-S1. The variations of model RF location, area, and length/width ratio with map location were all similar to previous observations. When elliptical RFs were simulated at the locations of the original cells, the RFs of real and simulated cells overlapped by 64%. The densities of cell representations of skin points on the hindlimb were represented as pseudocolor contour plots on dorsal view maps, and segmental representations were plotted on the standard views of the leg. Overlap of modeled and real segmental representations was at the 84% level. Simulated and observed RFs had similar relations between area and length/width ratio and location on the hindlimb: r(A) = 0.52; r(L/W) = 0.56. Although the representation of simple stimuli was orderly, and there was clearly only one somatotopic map of the skin, the representation of a single point often was not a single cluster of active neurons. When two-point stimuli were simulated, there usually was no fractionation of response zones or addition of new zones. Variation of stimulus size (area of skin contacted) produced less variation of representation size (number of cells responding) than movement of stimuli from one location to another. We conclude that stimulus features are preserved poorly in their dorsal horn spatial representation and that discrimination mechanisms that depend on detection of such

  18. Surveying woodland hawks with broadcasts of great horned owl vocalization

    USGS Publications Warehouse

    Mosher, James A.; Fuller, Mark R.

    1996-01-01

    Pre-recorded vocalizations of great horned owls (Bubo virginianus) broadcast into predominantly wooded habitat along roadside survey routes resulted in as many detections of resident red-shouldered hawks (Buteo lineatus) and Cooper's hawks (Accipiter cooperii) as broadcasts of each conspecific calls. Survey results for 3 species, expressed as average number of contacts/route, were directly related to the number of resident pairs located during systematic searches conducted on foot across the study area. Regression models based on road-transect counts were significant for predicting abundance of red-shouldered hawks, broad-winged hawks (Buteo platypterus), and Cooper's hawks from our study areas.

  19. Quantum Steganography via Greenberger-Horne-Zeilinger GHZ4 State

    NASA Astrophysics Data System (ADS)

    A. El, Allati; M. B. Ould, Medeni; Hassouni, Y.

    2012-04-01

    A quantum steganography communication scheme via Greenberger-Horne-Zeilinger GHZ4 state is constructed to investigate the possibility of remotely transferred hidden information. Moreover, the multipartite entangled states are become a hectic topic due to its important applications and deep effects on aspects of quantum information. Then, the scheme consists of sharing the correlation of four particle GHZ4 states between the legitimate users. After insuring the security of the quantum channel, they begin to hide the secret information in the cover of message. Comparing the scheme with the previous quantum steganographies, capacity and imperceptibility of hidden message are good. The security of the present scheme against many attacks is also discussed.

  20. Combined and controlled remote implementations of partially unknown quantum operations of multiqubits using Greenberger-Horne-Zeilinger states

    SciTech Connect

    Wang Anmin

    2007-06-15

    We propose and prove protocols of combined and controlled remote implementations of partially unknown quantum operations belonging to the restricted sets [A. M. Wang, Phys. Rev. A 74, 032317 (2006)] using Greenberger-Horne-Zeilinger (GHZ) states. We present the protocols in detail in the cases of one qubit, with two senders and with one controller, respectively. Then we study the variations of protocols with many senders, or with many controllers, or with both many senders and controllers using a multipartite GHZ state. Furthermore, we extend these protocols to the cases of multiqubits. Because our protocols have to request that the senders work together and transfer the information in turn or receive the repertoire of extra supercontrollers, or/and the controller(s) open the quantum channel and distribute the passwords in different ways, they definitely have the strong security in remote quantum information processing and communications. Moreover, the combined protocol with many senders is helpful to arrive at the power of remote implementations of quantum operations to the utmost extent in theory, since the different senders may have different operational resources and different operational rights in practice, and the controlled protocol with many controllers is able to enhance security and increase applications of remote implementations of quantum operations in engineering, since it has some common features in a controlled process.

  1. Combined and controlled remote implementations of partially unknown quantum operations of multiqubits using Greenberger-Horne-Zeilinger states

    NASA Astrophysics Data System (ADS)

    Wang, An Min

    2007-06-01

    We propose and prove protocols of combined and controlled remote implementations of partially unknown quantum operations belonging to the restricted sets [A. M. Wang, Phys. Rev. A 74, 032317 (2006)] using Greenberger-Horne-Zeilinger (GHZ) states. We present the protocols in detail in the cases of one qubit, with two senders and with one controller, respectively. Then we study the variations of protocols with many senders, or with many controllers, or with both many senders and controllers using a multipartite GHZ state. Furthermore, we extend these protocols to the cases of multiqubits. Because our protocols have to request that the senders work together and transfer the information in turn or receive the repertoire of extra supercontrollers, or/and the controller(s) open the quantum channel and distribute the passwords in different ways, they definitely have the strong security in remote quantum information processing and communications. Moreover, the combined protocol with many senders is helpful to arrive at the power of remote implementations of quantum operations to the utmost extent in theory, since the different senders may have different operational resources and different operational rights in practice, and the controlled protocol with many controllers is able to enhance security and increase applications of remote implementations of quantum operations in engineering, since it has some common features in a controlled process.

  2. 3 CFR - Unexpected Urgent Refugee and Migration Needs Related to the Horn of Africa

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Related to the Horn of Africa Presidential Documents Other Presidential Documents Presidential... Africa Memorandum for the Secretary of State By the authority vested in me as President by the... humanitarian crisis in the Horn of Africa. You are authorized and directed to publish this memorandum in...

  3. Nutritional Limitation on Growth and Development of Horn Fly (Diptera:Muscidae) Larvae

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Aging of bovine dung for 3-5 yr under refrigeration depleted nutrients required for growth and development of horn fly larvae. Growth of horn fly larvae in mixtures of nutrient-depleted dung and fresh dung resulted in production of larvae and pupae stunted in proportion to the relative amount of ag...

  4. Knockdown resistance in pyrethroid-resistant horn fly (Diptera: Muscidae) populations in Brazil

    Technology Transfer Automated Retrieval System (TEKTRAN)

    To investigate the kdr (knockdown resistance) resistance-associated gene mutation and determine its frequency in pyrethroid-resistant horn fly (Haematobia irritans) populations, a total of 1,804 horn flies of 37 different populations from all Brazilian regions (North, Northeast, Central-West, Southe...

  5. An Interview with Michael Horn: Blending Education for High-Octane Motivation

    ERIC Educational Resources Information Center

    Patterson, Gregory A.

    2012-01-01

    Blended learning holds the potential of improving the way we educate students and of making them more motivated. Blended education--the melding of information technology based distance learning with school attendance--is perhaps the best way to educate students for 21st century skills, says Michael Horn in a "Kappan" interview. Horn points out…

  6. Associations among heat shock protein 70 genotype, forage system, and horn fly infestation of beef cattle

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Horn fly infestations negatively impact economic traits of beef cattle. The impact of horn flies on beef cattle milk yield and quality was evaluated in cows sired by Bonsmara (BONS; n = 7), Brangus (BRAN; n = 13), Charolais (CHAR; n = 8), Gelbvieh (GELV; n = 5), Hereford (HERF; n = 12), and Romosin...

  7. Expressed gene sequences from egg and larval stages of the horn fly, Haematobia irritans

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We used an EST approach to initiate a study of the genome of the horn fly, Haematobia irritans and have isolated and sequenced 8,427 and 8,275 expressed genes from the egg and first instar larvae lifestages. Normalized cDNA libraries from eggs and first instar larvae from a field population of horn ...

  8. Pyrosequencing-based analysis of the microbiome associated with the horn fly, Haematobia irritans

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The horn fly, Haematobia irritans, is one of the economically important pests of cattle. Use of insecticides have been a major element of horn fly management programs. Growing concerns of insecticide resistance, insecticide residues on farm products, and non-availability of new generation insecticid...

  9. 49 CFR Appendix E to Part 222 - Requirements for Wayside Horns

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Requirements for Wayside Horns E Appendix E to Part 222 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD.... 222, App. E Appendix E to Part 222—Requirements for Wayside Horns This appendix sets forth...

  10. Milk production traits of beef cows as affected by horn fly count and sire breed type

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Horn fly infestations on beef cattle results in decreased productivity and challenges enterprise sustainability. Objective of this experiment was to determine the relationships among, cattle breed, heat shock protein 70 (Hsp70) genotype, and horn fly density. Angus (n = 20), Brahman (n = 17), and ...

  11. Rdl-containing Fragment of GABA(A) from the Horn Fly, Haematobia Irritans, Susceptible Genotype

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The horn fly, Haematobia irritans (L.), is a significant economic pest of cattle found throughout Europe, North Africa, Asia Minor, and the Americas. The major means of controlling the horn fly is through applications of chemicals with insecticidal activity. A cyclodiene-containing ear tag product h...

  12. Determination of the Phase Centers of Millimeter-Wave Horn Antennas Using a Holographic Interference Technique

    NASA Astrophysics Data System (ADS)

    McAuley, Ian; Murphy, J. Anthony; McCarthy, Darragh; Gradziel, Marcin; Mahon, Ronan; O'Sullivan, Creidhe; Trappe, Neil

    2016-04-01

    In this paper, we discuss how a holographic interference technique can be applied in the experimental determination of the phase centers of non-standard horn antennas in the millimeter-waveband. The phase center is the point inside the horn from which the radiation appears to emanate when viewed from the far-field, and knowing its location is necessary for optimizing coupling efficiencies to quasi-optical systems. For non-standard horn designs, and other feed structures, the phase center may be difficult to reliably predict by simulation, in which case, before committing to antenna manufacture, there is a requirement for it to be determined experimentally. Although the phase center can be recovered by direct phase measurement of the far-field beam pattern, this usually involves expensive instrumentation such as a vector network analyzer for millimeter wave horn antennas. In this paper, we describe one inexpensive alternative, which is based on measuring the interference pattern in intensity between the radiation from the horn of interest and a reference beam derived from the same coherent source in an off-axis holography setup. The accuracy of the approach is improved by comparison with the interference pattern of a well-understood standard horn (such as a corrugated conical horn) in the same experimental setup. We present an example of the technique applied to a profiled smooth-walled horn antenna, which has been especially designed for cosmic microwave background (CMB) polarization experiments.

  13. The Many Faces of Compliance: The Supreme Court's Decision in "Horne v. Flores"

    ERIC Educational Resources Information Center

    Thro, William E.

    2009-01-01

    At first blush, the Supreme Court's recent decision in "Horne v. Flores" (2009) appears to be about the proper standard for determining when to modify a previous judgment, a topic that would interest only civil procedure geeks. Yet, on closer examination, "Horne" is about giving local and state officials discretion to solve education problems and,…

  14. Exploring the Sensitivity of Horn's Parallel Analysis to the Distributional Form of Random Data

    ERIC Educational Resources Information Center

    Dinno, Alexis

    2009-01-01

    Horn's parallel analysis (PA) is the method of consensus in the literature on empirical methods for deciding how many components/factors to retain. Different authors have proposed various implementations of PA. Horn's seminal 1965 article, a 1996 article by Thompson and Daniel, and a 2004 article by Hayton, Allen, and Scarpello all make assertions…

  15. 454 pyrosequencing project identifying expressed genes from the horn fly, Haematobia irritans

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We used an EST approach to initiate a study of the genome of the horn fly, Haematobia irritans and have used 454 pyrosequencing techniques to sequence 73,512, 100,603, 71,550, and 85,769 expressed genes from the egg, first instar larvae, adult male, and adult female lifestages of the horn fly. cD...

  16. Longitudinally slotted conical horn antenna with small flare angle

    NASA Astrophysics Data System (ADS)

    Scharten, T.; Nellen, J.; van den Bogaart, F.

    1981-06-01

    The radiation and cross polarization characteristics of a longitudinally slotted, conical horn antenna with small flare angle, excited in the modified TE(11) mode, are investigated. To this end the electromagnetic wave propagation in a longitudinally slotted circular waveguide is studied first, using a wall reactance model. Because of the need to introduce mode-dependent wall reactances in the present structure, conditions for orthogonality are given. Propagation characteristics and field line patterns are presented. It turns out that the modified TE(11) mode in this guide, used as an aperture antenna, produces a main radiation lobe which can be made nearly symmetrical around the axis over a wide frequency range by a proper choice of the slot depth. As a typical example, the maximum cross polarization level in the main lobe is lower than -30 to -45 dB, dependent on slot depth and frequency range. Experiments carried out with a slotted conical horn antenna with small flare angle confirm the theoretical results.

  17. Preference of redear sunfish on zebra mussels and rams-horn snails

    USGS Publications Warehouse

    French, John R. P., III; Morgan, Michael N.

    1995-01-01

    We tested prey preferences of adult (200- to 222-mm long) redear sunfish (Lepomis microlophus) on two size classes of zebra mussels (Dreissena polymorpha) and two-ridge rams-horns (Helisoma anceps) in experimental aquaria. We also tested physical limitations on consuming these mollusks and determined prey bioenergetic profitability. Redear sunfish strongly preferred rams-horns over zebra mussels, but they displayed no size preference for either prey. Ingestion was not physically limited since both prey species up to 15-mm long fit within the pharyngeal gapes of redear sunfish. Rams-horns were more bioenergetically profitable than zebra mussels and ingestion of rams-horn shell fragments was about three times less than zebra mussels. Rams-horns were somewhat more resistant to shell-crushing, but all size ranges of both prey species tested were crushable by redear sunfish. These studies suggested that the redear sunfish should not be considered a panacea for biological control of zebra mussels.

  18. The value of hysteroscopy in the diagnostic approach to a rudimentary horn pregnancy.

    PubMed

    van Esch, E M G; Lashley, E E L O; Berning, B; de Kroon, C D

    2010-01-01

    A 33-year-old woman presented with an ectopic pregnancy without any complaints. Laparoscopy was performed since a tubal pregnancy was expected. However, both fallopian tubes appeared normal and it was not possible to differentiate accurately between a pregnancy in a non-communicating horn and a pregnancy in a bicornuate uterus. We therefore performed MRI which showed a thin myometrium around the pregnancy. In order to differentiate between a communicating and a non-communicating uterine horn the authors performed a hysteroscopy. Since there was only one cervical os, and an entrance to the second uterine cavity was not seen along the cervical canal, it was concluded that this pregnancy was situated in a non-communicating rudimentary horn. The non-communicating uterine horn, with the pregnancy in situ, was completely removed. Since a pregnancy in a bicornuate uterus is viable in contrast to a pregnancy in a non-communicating horn, accurate diagnosis is important. PMID:22802375

  19. Pangolin expression influences the development of a morphological novelty: beetle horns.

    PubMed

    Wasik, Bethany R; Moczek, Armin P

    2012-05-01

    Morphological diversity arises during development through the actions and interactions of diverse developmental pathways. Among those, the Wnt pathway is known to contribute to diverse developmental processes such as segmentation and the morphogenesis of appendages. Here, we characterize a transcription factor in the Wnt pathway, pangolin (pan), to investigate the role of Wnt signaling in the development of evolutionarily novel body structures: the horns of beetles. Beetle horns are highly diverse in size, shape, and number and develop principally from two major body regions: the head and prothorax. We investigate horns in two species of the genus Onthophagus using comparative in situ hybridization, larval RNA interference, and allometric measurements to analyze whether horn formation is regulated by pan and by extension the Wnt pathway. Our results illustrate that pan expression affects beetle horn growth in a species-, sex-, and location-specific manner in two morphologically distinct, yet closely-related, Onthophagus species. PMID:21998033

  20. Successful twin pregnancy in a unicornuate uterus with one fetus in the non-communicating rudimentary horn.

    PubMed

    Nanda, Smiti; Dahiya, Krishna; Sharma, Nidhi; Aggarwal, Deepika; Sighal, Savita Rani; Sangwan, Neetu

    2009-12-01

    Rudimentary horn is a rare anomaly and results from arrested development of the mullerian ducts. We report a case of twin pregnancy in a unicornuate uterus with a non-communicating rudimentary horn, in which two siblings each in separate horn were delivered successfully by caesarean section. PMID:19301025

  1. Multiplex Polymerase Chain Reaction in the Horn Fly: Detection of Pyrethroid, Organophosphate and Cyclodiene Target Site Resistance

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The horn fly, Haematobia irritans irritans, is an important pest to the livestock industry that causes economic losses of approximately US$1 billion in the U.S. and a similar value in Latin America. Horn fly control efforts still relies mainly on direct application of insecticides although horn fly ...

  2. Wave slamming on offshore structures

    NASA Astrophysics Data System (ADS)

    Miller, B. L.

    1980-03-01

    Experimental and theoretical work on the slamming of circular cylinders is surveyed. Data are included from controlled drop tests. The influence of inclined impact and beam dynamics on the resulting stresses is calculated for a wide range of wave conditions. The statistical distributions of the estimated stresses are analyzed to provide data for the calculation of slamming loads on fixed offshore structures using simple formulas in which the slamming coefficients incorporate both the member dynamics and the sea wave statistics. Slamming coefficients and associated stress calculation methods are presented for extreme values and fatigue damage. These may also be used for slamming during jacket launching. A film of wave slam was also produced.

  3. Offshore drilling and production structure

    SciTech Connect

    Crockett, R.K.; Palmer, H.E.; Stenning, D.G.

    1982-02-09

    The invention relates to an off-shore marine structure that provides an elevated support for a drilling and/or production platform. A structure comprised of three interlocking components is provided, the first component being a large foundation base installed on the sea bed; the second being a conical shaped support component which is engagable with the foundation base and which, releasably carries the third platform supporting component. In the preferred form, the platform supporting component comprises a centrally-disposed vertical column, means being provided to facilitate engagement of the column with the platform and the second component and to subsequently elevate the platform to an operating height above sea level.

  4. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import

    PubMed Central

    2011-01-01

    Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised. Results In our study, we have identified the cellular protein HIC (Human I-mfa domain-Containing protein) as a novel interactor of HIV-1 Rev. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin β and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. Hence, the molecular determinants mediating Rev-NLS recognition by importin β and transportin appear to be distinct. Furthermore, we have employed HIC and M9 M, a peptide specifically designed to inhibit the transportin-mediated nuclear import pathway, to characterise Rev nuclear import pathways within different cellular environments. Remarkably, we could show that in 293T, HeLa, COS7, Jurkat, U937, THP-1 and CEM cells, Rev nuclear import is cell type specific and alternatively mediated by transportin or importin β, in a mutually exclusive fashion. Conclusions Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy. PMID:21401918

  5. Trigeminal and spinal dorsal horn (dis)continuity and avian evolution.

    PubMed

    Wild, J Martin; Krützfeldt, Nils O E; Altshuler, Douglas L

    2010-01-01

    The organization of the dorsal horn in the avian spinal cord differs in different species. For instance, in pigeons and doves, cranes, cuckoos, songbirds, ratites and tinamous, the dorsal horn is organized in laminar fashion, such that laminae II and III are sandwiched between lamina I dorsally and lamina IV ventrally, as they are in mammals and other nonavian amniotes. In most other avian species, including chickens, however, the organization of the dorsal horn is not strictly laminar, in that the structures homologous to laminae II and III lie side by side rather than in dorsoventral order. Because spinal and trigeminal dorsal horns are generally thought to be continuous, the question arises as to the organization of the trigeminal dorsal horn in these species. We examined this question in chickens, first by defining II and III of trigeminal and spinal dorsal horns using calcium-binding protein immunohistochemistry, and second by determining the caudal extent of the projections of the three branches of the trigeminal nerve using injections of cholera toxin B chain. It was found (1) that the trigeminal dorsal horn and the spinal dorsal horn of the first 2 cervical segments are organized in laminar fashion, but further caudally, II and III in the spinal dorsal horn gradually come to be arranged side by side and (2) that the descending trigeminal tract terminates no further caudal than the 3rd spinal segment. Therefore, unlike spinal nerves, trigeminal nerve branches do not project to II and III, once these cease to be organized in laminar fashion. These findings imply some kind or organizational discontinuity of trigeminal and spinal dorsal horns in the chicken and perhaps in other species with a side-by-side arrangement of II and III. It has also been suggested that the condition in which the spinal dorsal horn structures homologous to laminae II and II lie side by side may define a novel clade of birds. This suggestion was reexamined within the context of a

  6. 31 CFR 547.406 - Offshore transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Offshore transactions. 547.406 Section 547.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... REGULATIONS Interpretations § 547.406 Offshore transactions. The prohibitions in § 547.201 on transactions...

  7. 31 CFR 542.406 - Offshore transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Offshore transactions. 542.406 Section 542.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... § 542.406 Offshore transactions. The prohibitions in § 542.201 on transactions involving...

  8. 31 CFR 588.406 - Offshore transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Offshore transactions. 588.406 Section 588.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... Interpretations § 588.406 Offshore transactions. The prohibitions in § 588.201 on transactions involving...

  9. 31 CFR 598.407 - Offshore transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Offshore transactions. 598.407 Section 598.407 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... Interpretations § 598.407 Offshore transactions. The prohibitions contained in § 598.203 apply to transactions...

  10. 31 CFR 543.406 - Offshore transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Offshore transactions. 543.406 Section 543.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... Interpretations § 543.406 Offshore transactions. The prohibitions in § 543.201 on transactions or...

  11. 31 CFR 546.406 - Offshore transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Offshore transactions. 546.406 Section 546.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... § 546.406 Offshore transactions. The prohibitions in § 546.201 on transactions or dealings...

  12. U.S. Offshore Wind Port Readiness

    SciTech Connect

    C. Elkinton, A. Blatiak, H. Ameen

    2013-10-13

    This study will aid decision-makers in making informed decisions regarding the choice of ports for specific offshore projects, and the types of investments that would be required to make individual port facilities suitable to serve offshore wind manufacturing, installation and/or operations.

  13. Domestic Options to Offshore Oil and Gas.

    ERIC Educational Resources Information Center

    Kash, Don E.

    1983-01-01

    The continuing controversey over offshore oil/gas has given impetus to searching for domestic energy alternatives. The need for and types of several alternative sources are discussed. Indicates that the United States needs to pursue both offshore and other domestic liquid-fuel sources if it is to avoid becoming increasingly dependent on imports.…

  14. Rudimentary horn pregnancy diagnosed by ultrasound and treated by laparoscopy--a case report and review of the literature.

    PubMed

    Kadan, Yfat; Romano, Shabtai

    2008-01-01

    Pregnancy in a rudimentary horn occurs once in 76,000 pregnancies. The most significant threat of pregnancy in a rudimentary horn is the risk of rupture. With the use of ultrasound the diagnosis can be made before symptoms occur. Management usually consists of excision of the rudimentary horn with the pregnancy and the ipsilateral tube, traditionally by laparotomy. We present a case of an 11-week pregnancy in a rudimentary horn with a nonviable fetus diagnosed by ultrasound and treated with laparoscopic resection. Review of the literature revealed 11 cases treated successfully with laparoscopic surgery. Laparoscopic treatment should be considered for pregnancy in rudimentary horn during the first trimester. PMID:18619925

  15. Rev-RRE Functional Activity Differs Substantially Among Primary HIV-1 Isolates.

    PubMed

    Jackson, Patrick E; Tebit, Denis M; Rekosh, David; Hammarskjold, Marie-Louise

    2016-09-01

    The HIV-1 replication cycle requires the nucleocytoplasmic export of intron-containing viral RNAs, a process that is ordinarily restricted. HIV overcomes this by means of the viral Rev protein, which binds to an RNA secondary structure called the Rev response element (RRE) present in all unspliced or incompletely spliced viral RNA transcripts. The resulting mRNP complex is exported through interaction with cellular factors. The Rev-RRE binding interaction is increasingly understood to display remarkable structural plasticity, but little is known about how Rev-RRE sequence differences affect functional activity. To study this issue, we utilized a lentiviral vector assay in which vector titer is dependent on the activity of selected Rev-RRE pairs. We found that Rev-RRE functional activity varies significantly (up to 24-fold) between naturally occurring viral isolates. The activity differences of the Rev-RRE cognate pairs track closely with Rev, but not with RRE activity. This variation in Rev activity is not correlated with differences in Rev steady state protein levels. These data suggest that Rev sequence differences drive substantial variation in Rev-RRE functional activity between patients. Such variation may play a role in viral adaptation to different immune milieus within and between patients and may be significant in the establishment of latency. The identification of differences in Rev-RRE functional activity in naturally occurring isolates may also permit more efficient production of lentiviral vectors. PMID:27147495

  16. Dynamics of a Prominence-horn Structure during Its Evaporation in the Solar Corona

    NASA Astrophysics Data System (ADS)

    Wang, Bing; Chen, Yao; Fu, Jie; Li, Bo; Li, Xing; Liu, Wei

    2016-08-01

    The physical connections among and formation mechanisms of various components of the prominence-horn cavity system remain elusive. Here we present observations of such a system, focusing on a section of the prominence that rises and separates gradually from the main body. This forms a configuration sufficiently simple to yield clues regarding the above issues. It is characterized by embedding horns, oscillations, and a gradual disappearance of the separated material. The prominence-horn structure exhibits a large-amplitude longitudinal oscillation with a period of ∼150 minutes and an amplitude of ∼30 Mm along the trajectory defined by the concave horn structure. The horns also experience a simultaneous transverse oscillation with a much smaller amplitude (∼3 Mm) and a shorter period (∼10–15 minutes), likely representative of a global mode of the large-scale magnetic structure. The gradual disappearance of the structure indicates that the horn, an observational manifestation of the field-aligned transition region separating the cool and dense prominence from the hot and tenuous corona, is formed due to the heating and diluting process of the central prominence mass; most previous studies suggested that it is the opposite process, i.e., the cooling and condensation of coronal plasmas, that formed the horn. This study also demonstrates how the prominence transports magnetic flux to the upper corona, a process essential for the gradual build-up of pre-eruption magnetic energy.

  17. Novel insights into the bovine polled phenotype and horn ontogenesis in Bovidae.

    PubMed

    Allais-Bonnet, Aurélie; Grohs, Cécile; Medugorac, Ivica; Krebs, Stefan; Djari, Anis; Graf, Alexander; Fritz, Sébastien; Seichter, Doris; Baur, Aurélia; Russ, Ingolf; Bouet, Stéphan; Rothammer, Sophie; Wahlberg, Per; Esquerré, Diane; Hoze, Chris; Boussaha, Mekki; Weiss, Bernard; Thépot, Dominique; Fouilloux, Marie-Noëlle; Rossignol, Marie-Noëlle; van Marle-Köster, Este; Hreiðarsdóttir, Gunnfríður Elín; Barbey, Sarah; Dozias, Dominique; Cobo, Emilie; Reversé, Patrick; Catros, Olivier; Marchand, Jean-Luc; Soulas, Pascal; Roy, Pierre; Marquant-Leguienne, Brigitte; Le Bourhis, Daniel; Clément, Laetitia; Salas-Cortes, Laura; Venot, Eric; Pannetier, Maëlle; Phocas, Florence; Klopp, Christophe; Rocha, Dominique; Fouchet, Michel; Journaux, Laurent; Bernard-Capel, Carine; Ponsart, Claire; Eggen, André; Blum, Helmut; Gallard, Yves; Boichard, Didier; Pailhoux, Eric; Capitan, Aurélien

    2013-01-01

    Despite massive research efforts, the molecular etiology of bovine polledness and the developmental pathways involved in horn ontogenesis are still poorly understood. In a recent article, we provided evidence for the existence of at least two different alleles at the Polled locus and identified candidate mutations for each of them. None of these mutations was located in known coding or regulatory regions, thus adding to the complexity of understanding the molecular basis of polledness. We confirm previous results here and exhaustively identify the causative mutation for the Celtic allele (PC) and four candidate mutations for the Friesian allele (PF). We describe a previously unreported eyelash-and-eyelid phenotype associated with regular polledness, and present unique histological and gene expression data on bovine horn bud differentiation in fetuses affected by three different horn defect syndromes, as well as in wild-type controls. We propose the ectopic expression of a lincRNA in PC/p horn buds as a probable cause of horn bud agenesis. In addition, we provide evidence for an involvement of OLIG2, FOXL2 and RXFP2 in horn bud differentiation, and draw a first link between bovine, ovine and caprine Polled loci. Our results represent a first and important step in understanding the genetic pathways and key process involved in horn bud differentiation in Bovidae. PMID:23717440

  18. Dynamics of a Prominence-horn Structure during Its Evaporation in the Solar Corona

    NASA Astrophysics Data System (ADS)

    Wang, Bing; Chen, Yao; Fu, Jie; Li, Bo; Li, Xing; Liu, Wei

    2016-08-01

    The physical connections among and formation mechanisms of various components of the prominence-horn cavity system remain elusive. Here we present observations of such a system, focusing on a section of the prominence that rises and separates gradually from the main body. This forms a configuration sufficiently simple to yield clues regarding the above issues. It is characterized by embedding horns, oscillations, and a gradual disappearance of the separated material. The prominence-horn structure exhibits a large-amplitude longitudinal oscillation with a period of ˜150 minutes and an amplitude of ˜30 Mm along the trajectory defined by the concave horn structure. The horns also experience a simultaneous transverse oscillation with a much smaller amplitude (˜3 Mm) and a shorter period (˜10–15 minutes), likely representative of a global mode of the large-scale magnetic structure. The gradual disappearance of the structure indicates that the horn, an observational manifestation of the field-aligned transition region separating the cool and dense prominence from the hot and tenuous corona, is formed due to the heating and diluting process of the central prominence mass; most previous studies suggested that it is the opposite process, i.e., the cooling and condensation of coronal plasmas, that formed the horn. This study also demonstrates how the prominence transports magnetic flux to the upper corona, a process essential for the gradual build-up of pre-eruption magnetic energy.

  19. Crossed receptive field components and crossed dendrites in cat sacrocaudal dorsal horn.

    PubMed

    Gladfelter, W E; Millecchia, R J; Pubols, L M; Sonty, R V; Ritz, L A; Covalt-Dunning, D; Culberson, J; Brown, P B

    1993-10-01

    The hypothesis that sacrocaudal dorsal horn neurons with crossed receptive field components on the tail have dendrites which cross to the contralateral dorsal horn was tested in a combined electrophysiological and morphological study. Dorsal horn cells in the sacrocaudal spinal cord of anesthetized cats were penetrated with horseradish peroxidase-filled microelectrodes. After mapping their low threshold mechanoreceptive fields, cells were iontophoretically injected with horseradish peroxidase. A sample of 16 well-stained cells was obtained in laminae III and IV. Cells with receptive fields crossing the dorsal midline of the tail (n = 8) had somata in the lateral ipsilateral dorsal horn, and some of these cells (5/8) had dendrites which crossed to the lateral contralateral dorsal horn. Cells with receptive fields spanning the ventral midline (n = 2) were located near the center of the fused dorsal horn, and one of these had bilateral dendrites in this region. Cells with receptive fields on the lateral tail, crossing neither the dorsal nor the ventral midline (n = 6), had cell bodies in the middle of the ipsilateral dorsal horn; half had only ipsilateral dendrites, and half had crossed dendritic branches. Although the relationship between cell receptive field (RF) location (RF center, expressed as distance from tips of toes) and mediolateral location of the cell body was statistically significant, the correlation between crossed RF components and crossed dendritic branches was not significant. PMID:8254116

  20. Somatotopic organization of single primary afferent axon projections to cat spinal cord dorsal horn.

    PubMed

    Brown, P B; Gladfelter, W E; Culberson, J C; Covalt-Dunning, D; Sonty, R V; Pubols, L M; Millecchia, R J

    1991-01-01

    Horseradish peroxidase injection of identified low threshold cutaneous mechanoreceptor (LTCM) primary afferent axons was used to assess the somatotopic organization of hindlimb projections to laminae III and IV of cat dorsal horn. Multiple injections in the same animals were used to assess bilateral symmetry and precision. Thirty-one axons were injected, with more than 1 axon injected in each of 8 animals (25 axons). Somatotopic relations between their receptive field (RF) centers and the centers of their dorsal horn projections were similar to the somatotopic relations between dorsal horn cell RF centers and cell locations. Very few reversals of mediolateral somatotopic gradients (proximodistal RF location as a function of mediolateral projection center) were observed. Two afferents with nearly identical RFs in 1 animal had nearly identical projections. These observations held for many different combinations of receptor types. A simple mathematical model was used to demonstrate that assembly of dorsal horn cell RFs via passive sampling of the presynaptic neuropil by dorsal horn cell dendrites cannot account for the sizes of dorsal horn cell LTCM RFs. Hypothesized mechanisms for assembly of dorsal horn cell RFs must take into account the functional selectivity of connections required to produce RFs smaller than those predicted by the passive assembly model. PMID:1702466

  1. Cross-linked hyaluronate hydrogel prevents adhesion formation and reformation in mouse uterine horn model.

    PubMed

    Sawada, T; Tsukada, K; Hasegawa, K; Ohashi, Y; Udagawa, Y; Gomel, V

    2001-02-01

    The aim of this study was to evaluate the efficacy of cross-linked hyaluronate hydrogel (HA gel) as an adjuvant for postoperative adhesion prevention, in a mouse uterine horn model. In experiment 1 uterine horns were abrased with iodine. HA gel was applied to the injured surface before closure in the treatment group. In experiment 2, after injuring the uterine horns, three stitches were placed at equal distances around the uterine horns to appose the injured medial surfaces of the two horns during healing. HA gel was inserted between the uterine horns in the treatment group. In experiment 3 prevention of adhesion reformation was assessed. After lysis of adhesions that were induced as in experiment 2, HA gel was introduced between the serosal surfaces of apposing uterine horns. Untreated animals served as controls in each experiment. Statistical analysis was carried out using Student's t-test. The adhesion score was significantly lower in the HA gel group on the 14th day compared with controls in all the experiments: in experiment 1, 0.3 +/- 0.4 versus 1.7 +/- 1.2; in experiment 2, 0.9 +/- 1.0 versus 2.6 +/- 0.5; and in experiment 3, 1.5 +/- 0.9 versus 2.2 +/- 0.6 respectively. Cross-linked HA gel significantly reduced de-novo adhesions (P< 0.03) and adhesion reformation (P < 0.03). PMID:11157833

  2. Efficient horn antennas for next-generation terahertz and millimeter-wave space telescopes

    NASA Astrophysics Data System (ADS)

    McCarthy, Darragh; Trappe, Neil; Murphy, Anthony; Bracken, Colm; Doherty, Stephen; Gradziel, Marcin L.; O'Sullivan, Créidhe

    2013-03-01

    Astronomical observations in the far-infrared are critical for investigation of cosmic microwave background (CMB) radiation and the formation and evolution of planets, stars and galaxies. In the case of space telescope receivers a strong heritage exists for corrugated horn antenna feeds to couple the far-infrared signals to the detectors mounted in a waveguide or cavity structure. Such antenna feeds have been utilized, for example, in the Planck satellite in both single-mode channels for the observation of the CMB and the multi-mode channels optimized for the detection of foreground sources. Looking to the demands of the future space missions, it is clear that the development of new technology solutions for the optimization and simplification of horn antenna structures will be required for large arrays. Horn antennas will continue to offer excellent control of beam and polarization properties for CMB polarisation experiments satisfying stringent requirements on low sidelobe levels, symmetry and low cross polarization in large arrays. Similarly for mid infrared systems multi-mode waveguide structures will give high throughput to reach the required sensitivities. In this paper we present a computationally efficient approach for modelling and optimising horn characteristics. We investigate smooth-walled profiled horns that have a performance equivalent to that of the corrugated horns traditionally used for CMB measurements. We discuss the horn optimisation process and the algorithms available to maximise performance of a merit parameter such as low cross polarisation or high Gaussicity.

  3. Responses of spinal dorsal horn neurons to foot movements in rats with a sprained ankle.

    PubMed

    Kim, Jae Hyo; Kim, Hee Young; Chung, Kyungsoon; Chung, Jin Mo

    2011-05-01

    Acute ankle injuries are common problems and often lead to persistent pain. To investigate the underlying mechanism of ankle sprain pain, the response properties of spinal dorsal horn neurons were examined after ankle sprain. Acute ankle sprain was induced manually by overextending the ankle of a rat hindlimb in a direction of plantarflexion and inversion. The weight-bearing ratio (WBR) of the affected foot was used as an indicator of pain. Single unit activities of dorsal horn neurons in response to plantarflexion and inversion of the foot or ankle compression were recorded from the medial part of the deep dorsal horn, laminae IV-VI, in normal and ankle-sprained rats. One day after ankle sprain, rats showed significantly reduced WBRs on the affected foot, and this reduction was partially restored by systemic morphine. The majority of deep dorsal horn neurons responded to a single ankle stimulus modality. After ankle sprain, the mean evoked response rates were significantly increased, and afterdischarges were developed in recorded dorsal horn neurons. The ankle sprain-induced enhanced evoked responses were significantly reduced by morphine, which was reversed by naltrexone. The data indicate that movement-specific dorsal horn neuron responses were enhanced after ankle sprain in a morphine-dependent manner, thus suggesting that hyperactivity of dorsal horn neurons is an underlying mechanism of pain after ankle sprain. PMID:21389306

  4. Novel Insights into the Bovine Polled Phenotype and Horn Ontogenesis in Bovidae

    PubMed Central

    Allais-Bonnet, Aurélie; Grohs, Cécile; Medugorac, Ivica; Krebs, Stefan; Djari, Anis; Graf, Alexander; Fritz, Sébastien; Seichter, Doris; Baur, Aurélia; Russ, Ingolf; Bouet, Stéphan; Rothammer, Sophie; Wahlberg, Per; Esquerré, Diane; Hoze, Chris; Boussaha, Mekki; Weiss, Bernard; Thépot, Dominique; Fouilloux, Marie-Noëlle; Rossignol, Marie-Noëlle; van Marle-Köster, Este; Hreiðarsdóttir, Gunnfríður Elín; Barbey, Sarah; Dozias, Dominique; Cobo, Emilie; Reversé, Patrick; Catros, Olivier; Marchand, Jean-Luc; Soulas, Pascal; Roy, Pierre; Marquant-Leguienne, Brigitte; Le Bourhis, Daniel; Clément, Laetitia; Salas-Cortes, Laura; Venot, Eric; Pannetier, Maëlle; Phocas, Florence; Klopp, Christophe; Rocha, Dominique; Fouchet, Michel; Journaux, Laurent; Bernard-Capel, Carine; Ponsart, Claire; Eggen, André; Blum, Helmut; Gallard, Yves; Boichard, Didier; Pailhoux, Eric; Capitan, Aurélien

    2013-01-01

    Despite massive research efforts, the molecular etiology of bovine polledness and the developmental pathways involved in horn ontogenesis are still poorly understood. In a recent article, we provided evidence for the existence of at least two different alleles at the Polled locus and identified candidate mutations for each of them. None of these mutations was located in known coding or regulatory regions, thus adding to the complexity of understanding the molecular basis of polledness. We confirm previous results here and exhaustively identify the causative mutation for the Celtic allele (PC) and four candidate mutations for the Friesian allele (PF). We describe a previously unreported eyelash-and-eyelid phenotype associated with regular polledness, and present unique histological and gene expression data on bovine horn bud differentiation in fetuses affected by three different horn defect syndromes, as well as in wild-type controls. We propose the ectopic expression of a lincRNA in PC/p horn buds as a probable cause of horn bud agenesis. In addition, we provide evidence for an involvement of OLIG2, FOXL2 and RXFP2 in horn bud differentiation, and draw a first link between bovine, ovine and caprine Polled loci. Our results represent a first and important step in understanding the genetic pathways and key process involved in horn bud differentiation in Bovidae. PMID:23717440

  5. Tongue adhesion in the horned frog Ceratophrys sp.

    NASA Astrophysics Data System (ADS)

    Kleinteich, Thomas; Gorb, Stanislav N.

    2014-06-01

    Frogs are well-known to capture elusive prey with their protrusible and adhesive tongues. However, the adhesive performance of frog tongues and the mechanism of the contact formation with the prey item remain unknown. Here we measured for the first time adhesive forces and tongue contact areas in living individuals of a horned frog (Ceratophrys sp.) against glass. We found that Ceratophrys sp. generates adhesive forces well beyond its own body weight. Surprisingly, we found that the tongues adhered stronger in feeding trials in which the coverage of the tongue contact area with mucus was relatively low. Thus, besides the presence of mucus, other features of the frog tongue (surface profile, material properties) are important to generate sufficient adhesive forces. Overall, the experimental data shows that frog tongues can be best compared to pressure sensitive adhesives (PSAs) that are of common technical use as adhesive tapes or labels.

  6. Presumptive electric cataracts in a Great Horned owl (Bubo virginianus).

    PubMed

    Dees, D Dustin; MacLaren, Nicole E

    2013-01-01

    This case report describes suspected electrocution in a juvenile female Great Horned owl (Bubo virginianus) with subsequent bilateral cataract formation. The bird flew into a high-voltage power line and was immediately rescued. Burn wounds of the head and ataxia with apparent blindness were noted. Initial ophthalmic examination 5 days after the incident revealed bilaterally symmetrical anterior subcapsular vacuolar cataracts with absence of intraocular inflammation and a predominantly clear view to the normal appearing fundus. The bird appeared to be nonvisual. No ophthalmic medications were prescribed at initial examination. Subsequent recheck examination at 8 weeks revealed moderate resolution of the cataracts and improved vision. To the authors' knowledge, this is the first published report of suspected electric cataracts in an avian species. PMID:22432797

  7. Pulmonary carcinoma in a great horned owl (Bubo virginianus).

    PubMed

    Rettenmund, Christy; Sladky, Kurt K; Rodriguez, Daniel; Petersen, Michael; Pinkerton, Marie E; Rao, Deepa

    2010-03-01

    Pulmonary carcinoma was diagnosed in an 18+-year-old captive female great horned owl (Bubo virginianus). The owl presented with a history of progressive weakness and sudden onset of frank blood in the droppings. On physical examination, the owl had multiple white to yellow plaques in the oral cavity, decreased air sac sounds on the right side, dyspnea (during manual restraint), and reduced pectoral musculature. Whole-body radiographs revealed obliteration of the right-sided air sacs, a soft tissue plaque/density in the left caudal thoracic air sac, soft tissue opacity over the coelomic organs, and increased medullary opacity in the distal right humerus. The owl died during anesthetic recovery, and the body was submitted for necropsy. Although the clinical signs, physical examination results, radiographic signs, and gross pathology supported a diagnosis of mycotic infection, such as aspergillosis, histopathology confirmed pulmonary carcinoma with metastases to the air sacs and humerus. PMID:20722257

  8. Synaptic inhibition and disinhibition in the spinal dorsal horn.

    PubMed

    Prescott, Steven A

    2015-01-01

    Nociceptive signals originating in the periphery must be transmitted to the brain to evoke pain. Rather than being conveyed unchanged, those signals undergo extensive processing in the spinal dorsal horn. Synaptic inhibition plays a crucial role in that processing. On the one hand, neuropathy and inflammation are associated with reduced spinal inhibition; on the other hand, the hypersensitivity associated with inflammatory and neuropathic pain can be reproduced by blocking inhibition at the spinal level. To understand the consequences of disinhibition and how to therapeutically reverse it, one must understand how synaptic inhibition normally operates. To that end, this chapter will discuss the structure and function of GABAA and glycine receptors together with the role of associated molecules involved in transmitter handling and chloride regulation. Mechanisms by which inhibition modulates cellular excitability will be described. The chapter will end with discussion of how inhibition goes awry under pathological conditions and what the implications are for the treatment of resulting pain. PMID:25744679

  9. Measurements of very low-sidelobe conical horn antennas

    NASA Technical Reports Server (NTRS)

    Toral, Marco A.; Ratliff, Roger B.; Lecha, Maria C.; Maruschak, John G.; Bennett, Charles L.

    1989-01-01

    A description is given of conical corrugated-horn antennas that were designed for millimeter-wave radiometers with a 7 degree field of view, namely the Differential Microwave Radiometers (DMRs) that will measure the large-angular-scale anisotropy of the cosmic background radiation that is generally thought to be the remnant of the primeval explosion, the Big Bang. The DMRs will be part of the Cosmic Background Explorer (COBE) satellite. Measured test results for three radiometers at 31.4, 53, and 90 GHz are reported along with those of a circular polarization orthomode transducer designed and characterized at 31.4 GHz. The measurement techniques and facilities are described, including an outdoor far-field facility where measurements down to levels 90 dB below the main beam maximum were achieved. The goal of achieving very low-sidelobe antennas with good symmetry has been demonstrated.

  10. Redefining ecological ethics: science, policy, and philosophy at Cape Horn.

    PubMed

    Frodeman, Robert

    2008-12-01

    In the twentieth century, philosophy (especially within the United States) embraced the notion of disciplinary expertise: philosophical research consists of working with and writing for other philosophers. Projects that involve non-philosophers earn the deprecating title of "applied" philosophy. The University of North Texas (UNT) doctoral program in philosophy exemplifies the possibility of a new model for philosophy, where graduate students are trained in academic philosophy and in how to work with scientists, engineers, and policy makers. This "field" (rather than "applied") approach emphasizes the inter- and transdisciplinary nature of the philosophical enterprise where theory and practice dialectically inform one another. UNT's field station in philosophy at Cape Horn, Patagonia, Chile is one site for developing this ongoing experiment in the theory and practice of interdisciplinary philosophic research and education. PMID:18941926

  11. A curious pellet from a great horned owl (Bubo virginianus)

    USGS Publications Warehouse

    Woodman, N.; Dove, C.J.; Peurach, S.C.

    2005-01-01

    One of the traditional methods of determining the dietary preferences of owls relies upon the identification of bony remains of prey contained in regurgitated pellets. Discovery of a pellet containing a large, complete primary feather from an adult, male Ring-necked Pheasant (Phasianus colchicus) prompted us to examine in detail a small sample of pellets from a Great Horned Owl (Bubo virginianus). Our analyses of feather and hair remains in these pellets documented the presence of three species of birds and two species of mammals, whereas bones in the pellets represented only mammals. This finding indicates an important bias that challenges the reliability of owl pellet studies making use of only osteological remains.

  12. Measurements of very low-sidelobe conical horn antennas

    NASA Astrophysics Data System (ADS)

    Toral, Marco A.; Ratliff, Roger B.; Lecha, Maria C.; Maruschak, John G.; Bennett, Charles L.

    1989-02-01

    A description is given of conical corrugated-horn antennas that were designed for millimeter-wave radiometers with a 7 degree field of view, namely the Differential Microwave Radiometers (DMRs) that will measure the large-angular-scale anisotropy of the cosmic background radiation that is generally thought to be the remnant of the primeval explosion, the Big Bang. The DMRs will be part of the Cosmic Background Explorer (COBE) satellite. Measured test results for three radiometers at 31.4, 53, and 90 GHz are reported along with those of a circular polarization orthomode transducer designed and characterized at 31.4 GHz. The measurement techniques and facilities are described, including an outdoor far-field facility where measurements down to levels 90 dB below the main beam maximum were achieved. The goal of achieving very low-sidelobe antennas with good symmetry has been demonstrated.

  13. Comparison between different rectangular horn elements for array antenna applications

    NASA Astrophysics Data System (ADS)

    Lier, E.; Rengarjan, S.; Rahmat-Samii, Y.

    1991-08-01

    The coupling and directivity characteristics of an array with fundamental smooth-walled, soft and hard open-ended waveguide elements with rectangular cross-section are considered. Exact and approximate methods to analyze coupling in arrays are discussed. It is known that the coupling, which can be expressed by a quadruple integral across the rectangular apertures, can be reduced to double integrals by introducing a coordinate transformation. Calculations show that the soft waveguide elements are suited for applications where low return loss and mutual coupling are required. Arrays with hard waveguide elements yield high directivity for limited scan applications. Both elements can, in contrast to conventional smooth-walled (SW) horns, operate in dual polarization with high isolation between the orthogonal modes.

  14. Entanglement concentration for concatenated Greenberger-Horne-Zeilinger state

    NASA Astrophysics Data System (ADS)

    Qu, Chang-Cheng; Zhou, Lan; Sheng, Yu-Bo

    2015-11-01

    The concatenated Greenberger-Horne-Zeilinger state is a new type of logic-qubit entanglement, which attracts a lot of attentions recently. In this paper, we discuss the entanglement concentration for such logic-qubit entanglement. We present two groups of entanglement concentration protocols (ECPs) for logic-qubit entanglement. In the first group, the parties do not know the initial coefficients of the partially logic-qubit entanglement. In the second group, the parties know the initial coefficients of the partially logic-qubit entanglement. In our ECPs, the unsuccessful cases can be reused to increase the total success probability in the next step. These ECPs may be useful in future long-distant quantum communication.

  15. An Anonymous Surveying Protocol via Greenberger-Horne-Zeilinger States

    NASA Astrophysics Data System (ADS)

    Naseri, Mosayeb; Gong, Li-Hua; Houshmand, Monireh; Matin, Laleh Farhang

    2016-06-01

    A new experimentally feasible anonymous survey protocol with authentication using Greenberger-Horne-Zeilinger (GHZ) entangled states is proposed. In this protocol, a chief executive officer (CEO) of a firm or company is trying to find out the effect of a possible action. In order to prepare a fair voting, the CEO would like to make an anonymous survey and is also interested in the total action for the whole company and he doesn't want to have a partial estimate for each department. In our proposal, there are two voters, Alice and Bob, voting on a question with a response of either "yes" or "no" and a tallyman, whose responsibility is to determine whether they have cast the same vote or not. In the proposed protocol the total response of the voters is calculated without revealing the actual votes of the voters.

  16. Past and Future Rainfall in the Horn of Africa

    NASA Astrophysics Data System (ADS)

    Tierney, J. E.; Ummenhofer, C.; deMenocal, P. B.

    2014-12-01

    While the interannual response of rainfall in the Greater Horn of Africa (GHA) region to internal climatic forcings is generally well understood, it is unclear how external climate forcing from rising greenhouse gases will affect hydroclimate in the region. 20th century observations in the GHA are limited in number, giving us only a hint at recent trends. Here, we present the first high-resolution record of temperature and hydroclimate from the GHA spanning the last 2000 years. These data, consisting of biomarker proxies measured in a high-accumulation rate marine sediment core from the Gulf of Aden, provide a detailed view of both 20th century and last millennium GHA climate. Measurements of TEX86 show that the recent warming in upper ocean temperatures is unprecedented in the context of the last 2000 years. Paired measurements of the hydrogen isotopic composition of leaf waxes show that the 20th century warming in the region is associated with a drying trend that is also unprecedented in the last 2000 years. These data suggest that rising greenhouse gases drive drying in the Horn of Africa region, but the majority of climate model simulations from the CMIP5 archive (RCP 8.5 scenario) imply that the region will get wetter. We address this discrepancy by investigating both the ability of climate models to simulate the seasonal cycle in rainfall in the GHA region and the mechanisms driving model response. If the models are incorrect, and the GHA will indeed get drier as a consequence of global warming, this has major implications for projections of food security in the region.

  17. BigHorn Home Improvement Center Energy Performance

    SciTech Connect

    Deru, M.; Pless, S. D.; Torcellini, P. A.

    2006-01-01

    The BigHorn Development Project, located in Silverthorne, Colorado, is one of the nation's first commercial building projects to integrate extensive high-performance design into a retail space. The BigHorn Home Improvement Center, completed in the spring of 2000, is a 42,366-ft2 (3,936 m2) hardware store, warehouse, and lumberyard. The authors were brought in at the design stage of the project to provide research-level guidance to apply an integrated design process and perform a postoccupancy evaluation. An aggressive energy design goal of 60% energy cost saving was set early in the process, which focused the efforts of the design team and provided a goal for measuring the success of the project. The extensive use of natural light, combined with energy-efficient electrical lighting design, provides good illumination and excellent energy savings. The reduced lighting loads, management of solar gains, and cool climate allow natural ventilation to meet the cooling loads. A hydronic radiant floor system, gas-fired radiant heaters, and a transpired solar collector deliver heat. An 8.9-kW roof-integrated photovoltaic (PV) system offsets a portion of the electricity. After construction, the authors installed monitoring equipment to collect energy performance data and analyzed the building's energy performance for two and one-half years. The authors also helped program the building controls and provided recommendations for improving operating efficiency. The building shows an estimated 53% energy cost saving and a 54% source energy saving. These savings were determined with whole-building energy simulations that were calibrated with measured data. This paper discusses lessons learned related to the design process, the daylighting performance, the PV system, and the heating, ventilating, and air-conditioning system.

  18. Erosional history of Big Horn basin: Mackin revisited

    SciTech Connect

    Palmquist, R.C.

    1983-08-01

    The classic study of the erosional history of Big Horn basin is by Mackin in 1937. In it he studied the terrace levels which ranged in age from Late Tertiary to late Pleistocene. He postulated that the terraces were the product of stream captures or intervals of interglacial stability alternating with glacial incision. More recent studies have revised Mackin's classically simple model. Detailed studies have increased the number of terrace levels, changed the timing of their stability episode, and estimated their ages. The number of terrace levels has been increased to nine along the Greybull and Bighorn Rivers and to six along the Shoshoni River. Because some of the different levels occur along each river, the number of unique levels within the basin is 12. The occurrence of a 600,000 and a 100,000 year old ash on two terrace levels allows the ages of the terraces to be estimated. The estimated ages range from 3 m.y. for the Tatman to 49,000 years for the Himes, which is the lowest level along the Bighorn River. Both ashes were deposited during river stability intervals and indicate that the Bighorn River and its eastern tributaries were stable late in the interglacial episodes. In contrast, the glaciofluvial gravels along the Shoshoni River at Cody indicate a late glacial stability episode for the western tributaries. The terrace cycles along the Bighorn River and its western tributaries are therefore out-of-phase. Comparison of the estimated terrace ages to termination in the marine isotopic record indicates that not all of the Pleistocene climatic cycles are preserved in the Big Horn basin terrace chronology.

  19. Unilateral intrauterine horn insemination of frozen semen in cats.

    PubMed

    Tsutsui, T; Tanaka, A; Takagi, Y; Nakagawa, K; Fujimoto, Y; Murai, M; Anzai, M; Hori, T

    2000-12-01

    Frozen feline semen was prepared using two types of extenders, egg yolk Tris-fructose citric acid (EYT-FC) and egg yolk sodium citrate solution (EYC), and the semen qualities after thawing and the conception rates obtained by unilateral intrauterine horn insemination (UIUI) were investigated. Cats used in the experiment were six males and 11 females aged 2-12 years (the number of experimental cases was 17). For preparation of frozen semen, semen collected by the artificial vagina method was adjusted to I x 10(8) sperm/m/ and 7% glycerol, put in 250 microl straws, and then frozen using a cell freezer. The mean sperm motility after thawing was 30.0+/-9.7 (SE) % in the semen prepared with EYT-FC and 30.0+/-3.3% in the semen prepared with EYC. Four of seven animals were fertilized by UIUI using two straws in both extenders, and the conception rate was 57.1%. The mean ratios of number of kits to the number of ovulations in the inseminated side were 61.1+/-24.5% and 30.5+/-3.4% for EYT-FC and EYC, respectively, showing that the ratio tended to be higher in the semen prepared with EYT-FC. The above findings, comparing the two extenders for preparation of frozen feline semen, showed that EYT-FC is slightly superior to EYC. To increase conception and fertility rates, it may be important to increase the sperm count for insemination and to inseminate both uterine horns. PMID:11193339

  20. Pyrosequencing-Based Analysis of the Microbiome Associated with the Horn Fly, Haematobia irritans

    PubMed Central

    Palavesam, Azhahianambi; Guerrero, Felix D.; Heekin, Andrew M.; Wang, Ju; Dowd, Scot E.; Sun, Yan; Foil, Lane D.; Pérez de León, Adalberto A.

    2012-01-01

    The horn fly, Haematobia irritans, is one of the most economically important pests of cattle. Insecticides have been a major element of horn fly management programs. Growing concerns with insecticide resistance, insecticide residues on farm products, and non-availability of new generation insecticides, are serious issues for the livestock industry. Alternative horn fly control methods offer the promise to decrease the use of insecticides and reduce the amount of insecticide residues on livestock products and give an impetus to the organic livestock farming segment. The horn fly, an obligatory blood feeder, requires the help of microflora to supply additional nutrients and metabolize the blood meal. Recent advancements in DNA sequencing methodologies enable researchers to examine the microflora diversity independent of culture methods. We used the bacterial 16S tag-encoded FLX-titanium amplicon pyrosequencing (bTEFAP) method to carry out the classification analysis of bacterial flora in adult female and male horn flies and horn fly eggs. The bTEFAP method identified 16S rDNA sequences in our samples which allowed the identification of various prokaryotic taxa associated with the life stage examined. This is the first comprehensive report of bacterial flora associated with the horn fly using a culture-independent method. Several rumen, environmental, symbiotic and pathogenic bacteria associated with the horn fly were identified and quantified. This is the first report of the presence of Wolbachia in horn flies of USA origin and is the first report of the presence of Rikenella in an obligatory blood feeding insect. PMID:23028533

  1. Genome-wide association reveals the locus responsible for four-horned ruminant.

    PubMed

    Kijas, James W; Hadfield, Tracy; Naval Sanchez, Marina; Cockett, Noelle

    2016-04-01

    Phenotypic variability in horn characteristics, such as their size, number and shape, offers the opportunity to elucidate the molecular basis of horn development. The objective of this study was to map the genetic determinant controlling the production of four horns in two breeds, Jacob sheep and Navajo-Churro, and examine whether an eyelid abnormality occurring in the same populations is related. Genome-wide association mapping was performed using 125 animals from the two breeds that contain two- and four-horned individuals. A case-control design analysis of 570 712 SNPs genotyped with the ovine HD SNP Beadchip revealed a strong association signal on sheep chromosome 2. The 10 most strongly associated SNPs were all located in a region spanning Mb positions 131.9-132.6, indicating the genetic architecture underpinning the production of four horns is likely to involve a single gene. The closest genes to the most strongly associated marker (OAR2_132568092) were MTX2 and the HOXD cluster, located approximately 93 Kb and 251 Kb upstream respectively. The occurrence of an eyelid malformation across both breeds was restricted to polled animals and those carrying more than two horns. This suggests the eyelid abnormality may be associated with departures from the normal developmental production of two-horned animals and that the two conditions are developmentally linked. This study demonstrated the presence of separate loci responsible for the polled and four-horned phenotypes in sheep and advanced our understanding of the complexity that underpins horn morphology in ruminants. PMID:26767438

  2. Computational modeling and experimental studies of the dynamic performance of ultrasonic horn profiles used in plastic welding.

    PubMed

    Roopa Rani, M; Rudramoorthy, R

    2013-03-01

    Ultrasonic horns are tuned components designed to vibrate in a longitudinal mode at ultrasonic frequencies. Reliable performance of such horns is normally decided by the uniformity of vibration amplitude at the working surface and the stress developed during loading condition. The horn design engineer must pay particular attention to designing a tool that will produce the desired amplitude without fracturing. The present work discusses horn configurations which satisfy these criteria and investigates the design requirements of horns in ultrasonic system. Different horn profiles for ultrasonic welding of thermoplastics have been characterized in terms of displacement amplitude and von-Mises stresses using modal and harmonic analysis. To validate the simulated results, five different horns are fabricated from Aluminum, tested and tuned to the operating frequency. Standard ABS plastic parts are welded using these horns. Temperature developed during the welding of ABS test parts using different horns is recorded using sensors and National Instruments (NIs) data acquisition system. The recorded values are compared with the predicted values. Experimental results show that welding using a Bezier horn has a high interface temperature and the welded joints had higher strength as compared to the other horn profiles. PMID:23259979

  3. Use of electroporation as an option to transform the horn fly, Haematobia irritans: a species recalcitrant to microinjection.

    PubMed

    Xu, Qiang; Guerrero, Felix D; Palavesam, Azhahianambi; Pérez de León, Adalberto A

    2016-08-01

    The horn fly, Haematobia irritans, is a serious pest of cattle in North America. The control of horn flies has primarily relied on insecticides. However, the heavy use of insecticides has led to the development of insecticide resistance in horn flies. Novel methods to control horn flies are greatly needed. Transgenic technology is an effective tool to genetically modify insects and may lead to novel methods of pest control based on genomic approaches. Here we report a piggyBac-mediated transformation of the horn fly via electroporation. Transformation with a DsRed fluorescent marker protein coding region was verified by PCR analysis of individual fly bodies and pupal cases and sequencing of PCR products. However, Southern blot analysis failed to indicate the DsRed gene was integrated into the horn fly genome. Thus, the electroporation protocol may have caused the DsRed gene to be integrated into bacterial symbionts of the horn fly. PMID:25645001

  4. Hand-assisted laparoscopic management of a midtrimester rudimentary horn pregnancy with placenta increta: a case report and literature review.

    PubMed

    Contreras, Karenrose R; Rothenberg, Jeffrey M; Kominiarek, Michelle A; Raff, Gregory J

    2008-01-01

    Pregnancy in a rudimentary horn is an extremely rare but serious obstetric condition. It is associated with uterine rupture and increased maternal mortality. The standard treatment is excision of the pregnancy and rudimentary horn. Several case reports describe a successful laparoscopic approach for rudimentary horn pregnancies diagnosed in the first trimester. A midtrimester rudimentary horn pregnancy was managed with a hand-assisted laparoscopic technique. This patient sought prenatal care at 19 weeks without any symptoms. A routine ultrasound found an empty uterus and an abdominal pregnancy was suggested. She subsequently had a hand-assisted laparoscopic delivery of a 19-week fetus with excision of the left-sided noncommunicating rudimentary horn. Intraoperative and pathologic findings were both consistent with a noncommunicating uterine horn pregnancy with placenta increta. Midtrimester rudimentary horn pregnancy can be successfully managed via hand-assisted laparoscopy in a patient who is hemodynamically stable. PMID:18722979

  5. User Instructions for the Systems Assessment Capability, Rev. 1, Computer Codes Volume 3: Utility Codes

    SciTech Connect

    Eslinger, Paul W.; Aaberg, Rosanne L.; Lopresti, Charles A.; Miley, Terri B.; Nichols, William E.; Strenge, Dennis L.

    2004-09-14

    This document contains detailed user instructions for a suite of utility codes developed for Rev. 1 of the Systems Assessment Capability. The suite of computer codes for Rev. 1 of Systems Assessment Capability performs many functions.

  6. Opiates and Pain Pathways: Demonstration of Enkephalin Synapses on Dorsal Horn Projection Neurons

    NASA Astrophysics Data System (ADS)

    Ruda, M. A.

    1982-03-01

    The participation of the opiate peptide enkephalin in the neural circuitry of the dorsal horn was examined at the light and ultrastructural level through the use of the combined techniques of immunocytochemistry and retrograde transport of horseradish peroxidase. Enkephalin immunoreactive axonal endings made direct synaptic contact with the soma and proximal dendrites of dorsal horn thalamic projection neurons. This observation demonstrates that one major synaptic site of enkephalin modulation of the transfer of nociceptive information in the dorsal horn is on the projection neurons themselves.

  7. AMPA receptor trafficking in inflammation-induced dorsal horn central sensitization

    PubMed Central

    Tao, Yuan-Xiang

    2012-01-01

    Activity-dependent postsynaptic receptor trafficking is critical for long-term synaptic plasticity in brain, but it is unclear whether this mechanism actually mediates spinal cord dorsal horn central sensitization (a specific form of synaptic plasticity) that is associated with persistent pain. Recent studies have shown that peripheral inflammation drives changes in AMPA receptor subunit trafficking in dorsal horn and that such changes contribute to the hypersensitivity that underlies persistent pain. Here, we review current evidence to illustrate how spinal cord AMPA receptors participate in dorsal horn central sensitization associated with persistent pain. Understanding these mechanisms may allow development of novel therapeutic strategies for treating persistent pain. PMID:22466122

  8. Cross polarization caused by perturbed circular cross sections of waveguides and horn antennas

    NASA Astrophysics Data System (ADS)

    Lier, Erik

    1987-03-01

    The cross polarization caused by a perturbed cross section of the conical hybrid-mode horn is analyzed. The perturbed cross section is assumed to be slightly elliptical. The theory of Lier and Bergh (1986) for cross polarization in a smooth-walled waveguide supporting the TE11-mode is referred and applied to the HE11 mode as well. Simple analytical formulas which are sufficiently accurate for small ellipticites of the cross-section ellipse are presented. These show that the tolerances on the waveguide diameter are extremely strong, typically on the order of 0.02-0.04 mm in the horn throat for typical horn geometries at 12 GHz.

  9. A GTD study of pyramidal horns for offset reflector antenna applications

    NASA Technical Reports Server (NTRS)

    Huang, J.; Rahmat-Samii, Y.; Woo, K.

    1983-01-01

    An efficient computational method is demonstrated for determining the far-field patterns of reflectors illuminated by pyramidal horns. A uniform geometrical theory of diffraction (GTD) formulation is used to determine the near- and far-fields of the horn. The far-field patterns of the offset reflector are constructed using the physical optics (PO) formulation in conjunction with the Jacobi-Bessel expansion method. Many representative results are shown for the far-field patterns of the reflector. In particular, the concept of the optimum phase center for the best location of a horn illuminating a reflector is carefully studied and some useful observations are made.

  10. Electrokinetic improvement of offshore foundations

    NASA Astrophysics Data System (ADS)

    Micic, Silvana

    Offshore and near-shore structures for energy exploration and production, harbour work and other facilities are often situated on very soft marine clay deposits that have shear strengths of a few kilopascals. The design of foundations embedded in these soft deposits often poses a challenge for geotechnical engineers, i.e., to satisfy the bearing capacity requirement, while at the same time minimizing the embedment depth and dimensions of the foundation due to cost considerations. The present study investigates the possibility of using electrokinetics to strengthen the soil adjacent to skirted foundations embedded in soft marine deposits and, thus, to improve the load carrying capacity of the foundations. The innovative feature of this approach as compared to soil improvement methods commonly adopted in practice is that the focus of strengthening is on the interface between the soil and embedded foundation, in terms of enhancement of adhesion and cementation. The thesis presents a summary of the method and results of a series of electrokinetic tests conducted on natural and simulated marine clays in small-scale and large-scale laboratory testing facilities. Steel plates and steel cylinders are used to simulate skirted foundations. A low dc voltage is applied via steel electrodes installed around the foundation models. The effects of electrokinetics are evaluated through changes in the geotechnical properties of the soil and load carrying capacities of the foundation model after treatment. The results demonstrate that the load carrying capacity of the skirted foundation model and the undrained shear strength of the adjacent soil increase by a factor of three after electrokinetic treatment. The clay adheres strongly to the inside and outside walls of the foundation model, indicating bonding occurs between the soil and steel after treatment. The treatment increases the soil undrained modulus and also induces a preconsolidation pressure of the remoulded clay, thereby

  11. Offshore Wind Energy Systems Engineering Curriculum Development

    SciTech Connect

    McGowan, Jon G.; Manwell, James F.; Lackner, Matthew A.

    2012-12-31

    Utility-scale electricity produced from offshore wind farms has the potential to contribute significantly to the energy production of the United States. In order for the U.S. to rapidly develop these abundant resources, knowledgeable scientists and engineers with sound understanding of offshore wind energy systems are critical. This report summarizes the development of an upper-level engineering course in "Offshore Wind Energy Systems Engineering." This course is designed to provide students with a comprehensive knowledge of both the technical challenges of offshore wind energy and the practical regulatory, permitting, and planning aspects of developing offshore wind farms in the U.S. This course was offered on a pilot basis in 2011 at the University of Massachusetts and the National Renewable Energy Laboratory (NREL), TU Delft, and GL Garrad Hassan have reviewed its content. As summarized in this report, the course consists of 17 separate topic areas emphasizing appropriate engineering fundamentals as well as development, planning, and regulatory issues. In addition to the course summary, the report gives the details of a public Internet site where references and related course material can be obtained. This course will fill a pressing need for the education and training of the U.S. workforce in this critically important area. Fundamentally, this course will be unique due to two attributes: an emphasis on the engineering and technical aspects of offshore wind energy systems, and a focus on offshore wind energy issues specific to the United States.

  12. Image processing in offshore engineering

    SciTech Connect

    Rodriguez, M.V.R.; A. Oliveira, M. de; Almeida, M.E.T. de; Lorenzoni, C.; Ferrante, A.J.

    1995-12-31

    The technological progress which has taken place during the last decade introduced a totally new outlook regarding the professional computational environment in general, and regarding the engineering profession in particular. During many years engineering computing was performed based on large computer centers, getting bigger and bigger all the time, going from mainframes to super computers, essentially producing numerical results on paper media. Lately, however, it has been realized that a much more productive computational environment can be implemented using an open architecture of client/server type, based on smaller lower cost equipment including workstations and PC`s, and considering engineering information in a broader sense. This papers reports briefly the experience of the Production Department of Petrobras in transforming its centralized, mainframe based, computational environment into a open distributed client/server computational environment, focusing on the problem of handling technical graphics information regarding its more than 70 fixed offshore platforms.

  13. 46 CFR 90.10-40 - Offshore supply vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Offshore supply vessels. 90.10-40 Section 90.10-40... PROVISIONS Definition of Terms Used in This Subchapter § 90.10-40 Offshore supply vessels. (a) An offshore..., supplies or equipment in support of exploration, exploitation, or production of offshore mineral or...

  14. 46 CFR 126.170 - Carriage of offshore workers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Carriage of offshore workers. 126.170 Section 126.170 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS INSPECTION AND CERTIFICATION General § 126.170 Carriage of offshore workers. (a) Offshore workers may be carried aboard an...

  15. Offshore drilling, construction: Fortunes tied to stable gas prices

    SciTech Connect

    Pagano, S.S.; Marsh, T.

    1993-01-01

    Significantly improved US natural gas prices fueled an upswing in offshore drilling in the Gulf of Mexico in late 1992. Stabilized gas prices will be necessary to support both the off-shore drilling and construction markets in 1993 and beyond. The article discusses both these segments in detail: offshore drilling and offshore construction.

  16. Offshore drilling to increase in 1984

    SciTech Connect

    Not Available

    1984-05-01

    A mid-year report presents a worldwide overview of offshore drilling operations. The Gulf of Mexico and the North Sea are posting substantial gains as companies rush to drill the millions of acres acquired in those sectors both last year and in previous offerings. The Middle East, Latin America and the Asia/Pacific offshore theaters will see only slight increases. The Mediterranean and African regions are expected to sustain declines. A region-by-region summary of the 1984 offshore forecast is presented showing exploration and appraisal activities, as well as development for all of these areas.

  17. Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) ζ, and Pol κ*

    PubMed Central

    Wojtaszek, Jessica; Lee, Chul-Jin; D'Souza, Sanjay; Minesinger, Brenda; Kim, Hyungjin; D'Andrea, Alan D.; Walker, Graham C.; Zhou, Pei

    2012-01-01

    DNA synthesis across lesions during genomic replication requires concerted actions of specialized DNA polymerases in a potentially mutagenic process known as translesion synthesis. Current models suggest that translesion synthesis in mammalian cells is achieved in two sequential steps, with a Y-family DNA polymerase (κ, η, ι, or Rev1) inserting a nucleotide opposite the lesion and with the heterodimeric B-family polymerase ζ, consisting of the catalytic Rev3 subunit and the accessory Rev7 subunit, replacing the insertion polymerase to carry out primer extension past the lesion. Effective translesion synthesis in vertebrates requires the scaffolding function of the C-terminal domain (CTD) of Rev1 that interacts with the Rev1-interacting region of polymerases κ, η, and ι and with the Rev7 subunit of polymerase ζ. We report the purification and structure determination of a quaternary translesion polymerase complex consisting of the Rev1 CTD, the heterodimeric Pol ζ complex, and the Pol κ Rev1-interacting region. Yeast two-hybrid assays were employed to identify important interface residues of the translesion polymerase complex. The structural elucidation of such a quaternary translesion polymerase complex encompassing both insertion and extension polymerases bridged by the Rev1 CTD provides the first molecular explanation of the essential scaffolding function of Rev1 and highlights the Rev1 CTD as a promising target for developing novel cancer therapeutics to suppress translesion synthesis. Our studies support the notion that vertebrate insertion and extension polymerases could structurally cooperate within a megatranslesion polymerase complex (translesionsome) nucleated by Rev1 to achieve efficient lesion bypass without incurring an additional switching mechanism. PMID:22859295

  18. Single-molecule studies reveal that DEAD box protein DDX1 promotes oligomerization of HIV-1 Rev on the Rev response element.

    PubMed

    Robertson-Anderson, Rae M; Wang, Jun; Edgcomb, Stephen P; Carmel, Andrew B; Williamson, James R; Millar, David P

    2011-07-29

    Oligomeric assembly of Rev on the Rev response element (RRE) is essential for the nuclear export of unspliced and singly spliced human immunodeficiency virus type 1 viral mRNA transcripts. Several host factors, including the human DEAD box protein DDX1, are also known to be required for efficient Rev function. In this study, spontaneous assembly and dissociation of individual Rev-RRE complexes in the presence or absence of DDX1 were observed in real time via single-molecule total internal reflection fluorescence microscopy. Binding of up to eight fluorescently labeled Rev monomers to a single RRE molecule was visualized, and the event frequencies and corresponding binding and dissociation rates for the different Rev-RRE stoichiometries were determined. The presence of DDX1 eliminated a second kinetic phase present during the initial Rev binding step, attributed to nonproductive nucleation events, resulting in increased occurrence of higher-order Rev-RRE stoichiometries. This effect was further enhanced upon the addition of a non-hydrolyzable ATP analog (adenylyl-imidophosphate), whereas ADP had no effect beyond that of DDX1 alone. Notably, the first three Rev monomer binding events were accelerated in the presence of DDX1 and adenylyl-imidophosphate, while the dissociation rates remained unchanged. Measurements performed across a range of DDX1 concentrations suggest that DDX1 targets Rev rather than the RRE to promote oligomeric assembly. Moreover, DDX1 is able to restore the oligomerization activity of a Rev mutant that is otherwise unable to assemble on the RRE beyond a monomeric complex. Taken together, these results suggest that DDX1 acts as a cellular cofactor by promoting oligomerization of Rev on the RRE. PMID:21763499

  19. Suppressing Side-Lobe Radiations of Horn Antenna by Loading Metamaterial Lens

    PubMed Central

    Qi, Mei Qing; Tang, Wen Xuan; Ma, Hui Feng; Pan, Bai Cao; Tao, Zui; Sun, Yong Zhi; Cui, Tie Jun

    2015-01-01

    We propose a new approach to control the amplitude and phase distributions of electromagnetic fields over the aperture of a horn antenna. By loading a metamaterial lens inside the horn antenna, a tapered amplitude distribution of the aperture field is achieved, which can suppress the side-lobe radiations of the antenna. The metamaterial is further manipulated to achieve a flat phase distribution on the horn aperture to avoid the gain reduction that usually suffers in the conventional low-sidelobe antenna designs. A prototype of the metamaterial-loaded horn antenna is designed and fabricated. Both numerical simulations and measured results demonstrate the tapered aperture-field distribution and significant reduction of side-lobe and back-lobe radiations in the operating frequency band. PMID:25766083

  20. Treatment of pastures with diflubenzuron suppresses Horn Fly, Haematobia irritans (L.) (Diptera: Muscidae) development

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Diflubenzuron is an insect growth regulator labeled for application to pastures and rangeland to suppress grasshopper (Orthoptera: Acrididae) populations. Livestock are permitted access to land immediately after treatment. We hypothesized that the development and survivorship of horn fly Haematobia ...

  1. Segmental aplasia of the uterine horn with ipsilateral renal agenesis in a cat.

    PubMed

    Chang, Jinhwa; Jung, Joo-hyun; Yoon, Junghee; Choi, Min-cheol; Park, Jae Hak; Seo, Kang-Moon; Jeong, Seong Mok

    2008-06-01

    A nine-month-old domestic short haired cat was admitted with the history of acute vomiting, depression and shivering. Abdominal ultrasonography revealed minimum enlargement of the right uterine horn filled with anechoic fluid. On excretory urography, functionally and anatomically normal, enlarged left kidney was found, but right kidney was absent. It was preliminary diagnosed as hydrometra with right renal agenesis. Aiming at the correction of hydrometra, we performed ovariohysterectomy. During spaying, we found a missing segment of distal part of the right uterine horn and absence of ipsilateral kidney and ureter. Compressed uterine structure and segmental aplasia of right uterine horn were found in histopathological investigation. Taken together, it was diagnosed as a segmental aplasia of uterine horn with ipsilateral renal agenesis. PMID:18628611

  2. 30 CFR 57.14132 - Horns and backup alarms for surface equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... NONMETAL MINES Machinery and Equipment Safety Devices and Maintenance Requirements § 57.14132 Horns and... shall be audible above the surrounding noise level. (3) An automatic reverse-activated strobe light...

  3. 30 CFR 57.14132 - Horns and backup alarms for surface equipment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... NONMETAL MINES Machinery and Equipment Safety Devices and Maintenance Requirements § 57.14132 Horns and... shall be audible above the surrounding noise level. (3) An automatic reverse-activated strobe light...

  4. Meniscus delivery: a maneuver for easy arthroscopic access to the posterior horn of the medial meniscus

    PubMed Central

    Said, Hatem Galal; Goyal, Saumitra; Fetih, Tarek Nabil

    2016-01-01

    Pathology of posterior horn of medial meniscus is common and often presents a difficult approach during arthroscopy for various reasons. We describe an easy maneuver to facilitate “delivery of the medial meniscus” during arthroscopy. PMID:27163099

  5. An Unusual Extremely Distant Noncommunicating Uterine Horn with Myoma and Adenomyosis Treated with Laparoscopic Hemihysterectomy

    PubMed Central

    Morelli, Michele; Mocciaro, Rita; Lico, Daniela; Zullo, Fulvio

    2013-01-01

    A 41-year-old woman referred to us with dysmenorrhea and severe pelvic pain although she was previously submitted to right laparotomic adnexectomy for ovarian endometrioma and to a subsequent operative laparoscopy for pelvic adhesions. After ultrasound examination, the patient underwent diagnostic hysteroscopy and operative laparoscopy which confirmed the clinic suspect of an unicornuate uterus. However, it was very unusual to see an extremely distanced right horn, without communication with uterus, without adnexa, and with a small myoma belonging to it. Moreover, omentum and bowel were attached to fundus of right horn and thick adhesions fixed it to rectum and right pelvic wall. Therefore, identification of anatomical structures was difficult, as it was extremely arduous to isolate the ureter, which was involved inside the adhesions surrounding the right uterine horn. Nevertheless, laparoscopic right hemihysterectomy was successfully performed and right horn was sent to our pathologist who recognized hypotrophic endometrium and adenomyosis. PMID:24109532

  6. Coring-type laparoscopic resection of a cavitated non-communicating rudimentary horn under hysteroscopic assistance.

    PubMed

    Akdemir, Ali; Ergenoglu, Ahmet Mete; Yeniel, Ahmet Özgür; Sendag, Fatih; Karadadaş, Nedim

    2014-07-01

    Non-communicating accessory uterine horns with an endometrial cavity are the most common and clinically significant unicornuate subtype of Müllerian duct abnormality. They are generally associated with symptoms of dysmenorrhea, dyspareunia, infertility, endometriosis, adhesions, and life-threatening cornual pregnancy. Treatment options include surgical resection of the rudimentary horn, hysteroscopic recanalization, and endometrial ablation. Currently, laparoscopic resection is the recommended treatment choice. Dissection of the rudimentary horn from the unicornuate uterus is the most challenging part of this procedure and may compromise the remaining unicornuate uterus wall. Here we describe a case of laparoscopic coring-type resection of a non-communicating functional rudimentary horn firmly attached to the unicornuate uterus, by using hysteroscopic assistance. The use of hysteroscopy, adjunct to laparoscopy, facilitates the coring-type resection and may strengthen the remaining myometrial scar. PMID:25056476

  7. Functional Rudimentary Horn as a Rare Cause of Pelvic Pain: A Case Report

    PubMed Central

    Arab, Maliheh; Mehdighalb, Sepideh; Khosravi, Donya

    2014-01-01

    Introduction: Pelvic pain results from many causes such as primary dysmenorrhea, uterine anomalies, menstrual outflow obstruction, endometriosis, myoma and adenomyosis. This study reports on a rare case of non-communicating functional rudimentary horn. Case Presentations: A 15-year-old nulligravida young woman with a history of severe intermittent pelvic pain presented a 4-5 centimeter mass. A surgical procedure for appendicitis was previously performed on this patient. Per-operative diagnosis was myoma and suspicion of leismus sarcoma. Laparotomy revealed left rudimentary horn, non-communication was confirmed by postoperative hysterosalpingogram (HSG) and magnetic resonance imaging (MRI). Resection of mass and left fallopian tube was done during the second surgery. Conclusions: Rudimentary horn should be considered in differentiation of pelvic pain and mass in young females. Early diagnosis and horn resection prevents emergency surgery and reliefs pain. PMID:25763218

  8. A rare case of intact rudimentary horn pregnancy presenting as hemoperitoneum.

    PubMed

    Jain, Ruchi; Gami, Neha; Puri, Manju; Trivedi, Ss

    2010-05-01

    The availability of technological advances like ultrasonography (USG) and magnetic resonance imaging (MRI) has made the diagnosis of rudimentary horn pregnancy possible at an early gestation. However, in advanced pregnancy, such cases can sometimes pose a diagnostic dilemma and are recognized only when patient presents with abdominal pain and collapse and is taken for laparotomy. We report one such rare case of a nulliparous female who was carrying on well with her pregnancy till she developed symptoms of acute abdomen at 28 weeks of gestation. She underwent USG and MRI but it was only after laparotomy that a final diagnosis of a pregnancy in a rudimentary horn with placenta percreta perforating through the fundus could be made. There was a significant amount of hemoperitoneum; however, the horn was intact and the fetus could be salvaged. We excised the rudimentary horn with ipsilateral tube and ovary. Post operatively, both the mother and the baby were discharged in healthy condition. PMID:21209759

  9. Anterior horn syndrome: A rare manifestation of primary Sjögren's syndrome.

    PubMed

    Zahlane, Safaa; Louhab, Nissrine; El Mellakh, Meriem; Kissani, Najib

    2016-07-01

    The authors report an exceptional case of an anterior horn syndrome associated with Sjögren's syndrome in a 58-year-old patient with a flaccid tetraparesis revealed by asymmetric atrophy and diffuse fasciculations associated with xerostomia and xerophthalmia. The electroneuromyography objectified a diffuse anterior horn syndrome. The brain MRI and spinal cord were normal. Laboratory tests revealed positive anti-SSA and anti-SSB antibody. The salivary glands biopsy objectified lymphocytic sialadenitis grade 3 of Chisholm. The Schirmer's test was abnormally low. Diagnosis of anterior horn syndrome as part of Sjögren's syndrome was retained. The methylprednisolone bolus allowed partial clinical improvement after 12 months of evolution. Therefore, in patients with isolated anterior horn involvement, a correct diagnosis of the underlying SS is often delayed or overlooked entirely; in these instances, standard clinicoserological assessment is recommendable. PMID:27118221

  10. Application of rectangular and elliptical dielcore feed horns to elliptical reflector antennas

    NASA Astrophysics Data System (ADS)

    Lier, Erik; Rahmat-Samii, Yahya; Rengarajan, Sembiam R.

    1991-11-01

    The pattern characteristics of elliptical reflector antennas are investigated when they are fed by rectangular and elliptical horns partially filled with a dielectric. The bandwidth characteristics of these dielcore horns are superior to those of their corrugated horn counterparts. Representative reflector patterns are computed to properly demonstrate the utility of these feeds for reflector antennas with elliptical apertures. This reflector antenna exhibits high efficiency and low cross polarization, and may be suitable for radar and satellite antenna applications. The antenna configuration may become useful in relatively small antennas where more than 10 percent cross-polar bandwidth is required. The efficient dielcore horns may also be used as feeds for elliptical nonshaped dual-reflector antennas.

  11. The Morgan Recharger: a new horn fly (Diptera: Muscidae) control device for beef cattle.

    PubMed

    Barton, W E; Gray, E W; Noblet, R; Thompson, C E

    1990-08-01

    A 20% diazinon formulation was evaluated for control efficacy against the horn fly, Haematobia irritans (L.), in the Morgan Recharger (Morgan International Products, College Grove, Tenn.). The Morgan Recharger releases insecticide with a wicking system from an insecticide reservoir and can be attached to an animal's ear or tail. This device was most effective against the horn fly when used as an ear tag with two per head; horn fly counts did not exceed five flies per side through 8 wk. The diazinon formulation tested was released from the Morgan Recharger at a decreasing rate. The problems and potential of the Morgan Recharger as an effective horn fly control device are discussed. PMID:2212237

  12. Suppressing side-lobe radiations of horn antenna by loading metamaterial lens.

    PubMed

    Qi, Mei Qing; Tang, Wen Xuan; Ma, Hui Feng; Pan, Bai Cao; Tao, Zui; Sun, Yong Zhi; Cui, Tie Jun

    2015-01-01

    We propose a new approach to control the amplitude and phase distributions of electromagnetic fields over the aperture of a horn antenna. By loading a metamaterial lens inside the horn antenna, a tapered amplitude distribution of the aperture field is achieved, which can suppress the side-lobe radiations of the antenna. The metamaterial is further manipulated to achieve a flat phase distribution on the horn aperture to avoid the gain reduction that usually suffers in the conventional low-sidelobe antenna designs. A prototype of the metamaterial-loaded horn antenna is designed and fabricated. Both numerical simulations and measured results demonstrate the tapered aperture-field distribution and significant reduction of side-lobe and back-lobe radiations in the operating frequency band. PMID:25766083

  13. Intersexuality associated with XX/XY mosaicism in a horned goat.

    PubMed

    Bongso, T A; Thavalingam, M; Mukherjee, T K

    1982-01-01

    Anatomical, histological, and cytogenetic studies were undertaken on a horned intersex goat kid and three of its normal litter mates. The intersex had male type horns, male beard, vestigial mammary glands, female external genitalia, and an enlarged peniform clitoris, exuded a pungent male odor, had a male bleat, and came into estrus every 20 days. At laparotomy and subsequent slaughter, an ovotestes was observed on the right side and a testis and epididymal remnants on the left side. Uterine horn segments, cervix, vagina, and enlarged clitoris (2 cm) were also present. Histologically, spermatogenesis was not observed in either testis, but active Leydig cells were present. The ovary contained mature follicles. Chromosome analysis revealed 60XX/60XY cell populations in blood, bone marrow, and skin. Lymphocytic metaphases from the male and female cosibs showed single populations of 60XY and 60XX, respectively. Mosaicism associated with the horned condition in the intersex goat was established. PMID:7160233

  14. 17 CFR 230.135e - Offshore press conferences, meetings with issuer representatives conducted offshore, and press...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... RULES AND REGULATIONS, SECURITIES ACT OF 1933 General § 230.135e Offshore press conferences, meetings... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Offshore press conferences, meetings with issuer representatives conducted offshore, and press-related materials released offshore....

  15. The complete mitochondrial genome of scimitar-horned oryx (Oryx dammah).

    PubMed

    Zhang, Honghai; Ren, Ying; Chen, Lei; Sha, Weilai

    2012-10-01

    In this study, a blood sample was obtained from a scimitar-horned oryx in Jinan Paomaling World of Wildlife and the complete nucleotide sequence of scimitar-horned oryx mitochondrial genome was determined. Sequence analysis showed that the genome structure was in accordance with other bovid species that it contained 22 tRNA genes, 12S rRNA gene, 16S rRNA gene, 13 protein-coding genes and 1 control region. PMID:22775428

  16. Detached Anterior Horn of the Medial Meniscus Mimicking a Parameniscal Cyst

    PubMed Central

    Fukuta, Shoji; Tsutsui, Takahiko; Matsuura, Tetsuya; Suzue, Naoto; Hamada, Daisuke; Goto, Tomohiro; Sairyo, Koichi

    2015-01-01

    We report a case of a detached anterior horn of the medial meniscus with anterior knee pain. Preoperative magnetic resonance images of the knee were initially interpreted as a parameniscal cyst. Arthroscopic examination revealed subluxation of the anterior horn of the medial meniscus due to detachment from its anterior tibial insertion. Arthroscopic fixation with a suture anchor was successful and the cystic lesion was no longer visible on postoperative images. PMID:26550510

  17. Mortality in fledgling great horned owls from black fly hematophaga and leucocytozoonosis.

    PubMed

    Hunter, D B; Rohner, C; Currie, D C

    1997-07-01

    Black fly feeding alone and in concert with Leucocytozoon spp. infection caused mortality in fledgling great horned owls (Bubo virginianus) in the Yukon, Canada 1990 to 1991. These mortalities occurred during a year of food shortage corresponding with a decline in the population of snowshoe hare (Lepus americanus), the main prey for great horned owls. We hypothesize an interaction between food availability and the consequences of host-parasite interactions. PMID:9249694

  18. Congenital deficiency of the fibula with ipsilateral iliac horn and absence of the kidney.

    PubMed

    Haga, N; Lee, K; Nakamura, K; Okazaki, Y; Mamada, K; Kurokawa, T

    1997-04-01

    Congenital deficiency of the fibula is sometimes accompanied by femoral hypoplasia, genu valgum, patellar a/hypoplasia or dislocation, tibial bowing, foot deformity, and toe deficiency in the affected limb. 'Iliac horns' are bony projections extending posterolaterally from the ilium and considered to be pathognomonic of nail-patella syndrome. We report a 5-year-old Japanese girl with congenital complete deficiency of the left fibula, ipsilateral iliac horn and absence of the left kidney. PMID:9134300

  19. [Successful laparoscopic management of a non-communicating rudimentary horn pregnancy].

    PubMed

    Szabó, István; Börzsönyi, Balázs; Demendi, Csaba; Langmár, Zoltán

    2009-03-15

    Pregnancy in a rudimentary horn is a rare entity with the most significant risk of life-threatening intraabdominal bleeding caused by rupture. With the use of vaginal ultrasonography, an early diagnosis can be made before symptoms occur. Management consists of laparoscopic resection of the rudimentary horn with the pregnancy and the ipsilateral tube. Authors present a case of a 9-week pregnancy successfully treated with laparoscopic resection. PMID:19258247

  20. Case report of ruptured non-communicating right rudimentary horn pregnancy: an acute emergency.

    PubMed

    Hassan, Che Hasnura Che; Karim, Abdul Kadir Abdul; Ismail, Nor Azlin Mohamed; Omar, Mohd Hashim

    2011-01-01

    Ruptured pregnancy in the rudimentary horn of women who have had a vaginal delivery is rare and unpredictable. However, when undiagnosed, this condition could lead to maternal morbidity and mortality. We report a pregnancy at 19 weeks gestation presented with acute abdomen and hypovolemic shock. She was initially thought to have an intrauterine pregnancy with the provisional diagnosis of a ruptured uterus. Intraoperatively, a ruptured non-communicating right rudimentary horn with ex utero pregnancy was discovered. PMID:22250483

  1. A rare case of heterotopic pregnancy with ruptured left rudimentary horn pregnancy.

    PubMed

    Rathod, Setu; Samal, Sunil Kumar

    2015-03-01

    Heterotopic pregnancy(HP) occurs when intrauterine and ectopic pregnancies coexist. We report a case of HP at 14 wk of gestation presenting as ruptured left rudimentary horn ectopic pregnancy with live intrauterine gestation and was managed with emergency laparotomy followed by resection of left rudimentary non communicating horn of uterus. The intrauterine pregnancy continued uneventfully. A female baby was delivered vaginally at 41 wk following induction of labour. PMID:25954670

  2. HIGH ENERGY PULSED POWER SYSTEM FOR AGS SUPER NEUTRINO FOCUSING HORN.

    SciTech Connect

    ZHANG, S.Y.; SANDBERG, J.; WENG, W.-T.

    2005-05-16

    This paper present a preliminary design of a 300 kA, 2.5 Hz pulsed power system. This system will drive the focusing horn of proposed Brookhaven AGS Neutrino Super Beam Facility for Very Long Baseline Neutrino Oscillation Experiment. The peak output power of the horn pulsed power system will reach Giga-watts, and the upgraded AGS will be capable of delivering 1 MW in beam power.

  3. A Rare Case of Heterotopic Pregnancy with Ruptured Left Rudimentary Horn Pregnancy

    PubMed Central

    Rathod, Setu

    2015-01-01

    Heterotopic pregnancy(HP) occurs when intrauterine and ectopic pregnancies coexist. We report a case of HP at 14 wk of gestation presenting as ruptured left rudimentary horn ectopic pregnancy with live intrauterine gestation and was managed with emergency laparotomy followed by resection of left rudimentary non communicating horn of uterus. The intrauterine pregnancy continued uneventfully. A female baby was delivered vaginally at 41 wk following induction of labour. PMID:25954670

  4. Properties of cutoff corrugated surfaces for corrugated horn design. [corrugation shape and density effects on scattering

    NASA Technical Reports Server (NTRS)

    Mentzer, C. A.; Peters, L., Jr.

    1974-01-01

    Corrugated horns involve a junction between the corrugated surface and a conducting ground plane. Proper horn design requires an understanding of the electromagnetic properties of the corrugated surface and this junction. An integral equation solution has been used to study the influence of corrugation density and tooth thickness on the power loss, surface current, and the scattering from a ground plane/corrugated surface junction.

  5. Insights into the Development and Evolution of Exaggerated Traits Using De Novo Transcriptomes of Two Species of Horned Scarab Beetles

    PubMed Central

    Warren, Ian A.; Vera, J. Cristobal; Johns, Annika; Zinna, Robert; Marden, James H.; Emlen, Douglas J.; Dworkin, Ian; Lavine, Laura C.

    2014-01-01

    Scarab beetles exhibit an astonishing variety of rigid exo-skeletal outgrowths, known as “horns”. These traits are often sexually dimorphic and vary dramatically across species in size, shape, location, and allometry with body size. In many species, the horn exhibits disproportionate growth resulting in an exaggerated allometric relationship with body size, as compared to other traits, such as wings, that grow proportionately with body size. Depending on the species, the smallest males either do not produce a horn at all, or they produce a disproportionately small horn for their body size. While the diversity of horn shapes and their behavioural ecology have been reasonably well studied, we know far less about the proximate mechanisms that regulate horn growth. Thus, using 454 pyrosequencing, we generated transcriptome profiles, during horn growth and development, in two different scarab beetle species: the Asian rhinoceros beetle, Trypoxylus dichotomus, and the dung beetle, Onthophagus nigriventris. We obtained over half a million reads for each species that were assembled into over 6,000 and 16,000 contigs respectively. We combined these data with previously published studies to look for signatures of molecular evolution. We found a small subset of genes with horn-biased expression showing evidence for recent positive selection, as is expected with sexual selection on horn size. We also found evidence of relaxed selection present in genes that demonstrated biased expression between horned and horn-less morphs, consistent with the theory of developmental decoupling of phenotypically plastic traits. PMID:24586317

  6. Offshore oil in the Alaskan Arctic

    NASA Technical Reports Server (NTRS)

    Weeks, W. F.; Weller, G.

    1984-01-01

    Oil and gas deposits in the Alaskan Arctic are estimated to contain up to 40 percent of the remaining undiscovered crude oil and oil-equivalent natural gas within U.S. jurisdiction. Most (65 to 70 percent) of these estimated reserves are believed to occuur offshore beneath the shallow, ice-covered seas of the Alaskan continental shelf. Offshore recovery operations for such areas are far from routine, with the primary problems associated with the presence of ice. Some problems that must be resolved if efficient, cost-effective, environmentally safe, year-round offshore production is to be achieved include the accurate estimation of ice forces on offshore structures, the proper placement of pipelines beneath ice-produced gouges in the sea floor, and the cleanup of oil spills in pack ice areas.

  7. Proceedings of offshore and arctic operations, 1992

    SciTech Connect

    Tawfik, A.S. ); Attia, F.G. )

    1992-01-01

    This book contains the proceeding of the offshore and Arctic operations. Topics included are: Pile driving; Flexible pipes; QA/QC Requirements; Oil and gas exploitations and Off shore well-log analysis.

  8. Engineering Challenges for Floating Offshore Wind Turbines

    SciTech Connect

    Butterfield, S.; Musial, W.; Jonkman, J.; Sclavounos, P.

    2007-09-01

    The major objective of this paper is to survey the technical challenges that must be overcome to develop deepwater offshore wind energy technologies and to provide a framework from which the first-order economics can be assessed.

  9. Requirements for construction of offshore concrete platforms

    SciTech Connect

    Gudmestad, O.T.; Pollard, N.

    1994-12-31

    For development of offshore fields, the operator must select production concepts. As several options like subsea templates, floating production and storage concepts, semisubmersibles and steel platforms etc. are available, this paper will review the specifics of one of the possible concepts, the concrete platform. The application of offshore concrete platforms is gaining renewed interest world wide. Several operators are presently carrying out comparisons between offshore concrete structures and jacket support structures. This evaluation includes considerations related to constructability incorporating studies of potential construction sites, and infrastructures as well as availability of materials. This paper summarizes requirements for carrying out an offshore concrete platform construction project and will be useful to those interested in concrete projects.

  10. Ruptured Rudimentary Horn Pregnancy Diagnosed by Preoperative Magnetic Resonance Imaging Resulting in Fetal Salvage

    PubMed Central

    Pillai, Silja A.; Mathew, Mariam; Ishrat, Noreen; Kakaria, Anupam; Qureshi, Asim; Vaidyanathan, Gowri

    2015-01-01

    Pregnancy in a rudimentary horn is very rare. The rupture of the horn during pregnancy is an obstetric emergency which can be life-threatening for both the mother and fetus. Preoperative diagnosis of such pregnancies can be challenging and they are usually diagnosed intraoperatively. We report a unique case of a 31-year-old multiparous woman who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in January 2013 at 32 gestational weeks with abdominal pain. Ultrasonography was inconclusive. A rudimentary horn pregnancy was subsequently diagnosed via magnetic resonance imaging (MRI). An emergency laparotomy revealed haemoperitoneum and a ruptured rudimentary horn pregnancy. A live baby with an Apgar score of 2 at one minute and 7 at five minutes was delivered. The rudimentary horn with the placenta in situ was excised and a left salpingo-oophorectomy was performed. The postoperative period was uneventful. The authors recommend MRI as an excellent diagnostic modality to confirm rudimentary horn pregnancies and to expedite appropriate management. PMID:26357563

  11. Ruptured Rudimentary Horn Pregnancy Diagnosed by Preoperative Magnetic Resonance Imaging Resulting in Fetal Salvage.

    PubMed

    Pillai, Silja A; Mathew, Mariam; Ishrat, Noreen; Kakaria, Anupam; Qureshi, Asim; Vaidyanathan, Gowri

    2015-08-01

    Pregnancy in a rudimentary horn is very rare. The rupture of the horn during pregnancy is an obstetric emergency which can be life-threatening for both the mother and fetus. Preoperative diagnosis of such pregnancies can be challenging and they are usually diagnosed intraoperatively. We report a unique case of a 31-year-old multiparous woman who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in January 2013 at 32 gestational weeks with abdominal pain. Ultrasonography was inconclusive. A rudimentary horn pregnancy was subsequently diagnosed via magnetic resonance imaging (MRI). An emergency laparotomy revealed haemoperitoneum and a ruptured rudimentary horn pregnancy. A live baby with an Apgar score of 2 at one minute and 7 at five minutes was delivered. The rudimentary horn with the placenta in situ was excised and a left salpingo-oophorectomy was performed. The postoperative period was uneventful. The authors recommend MRI as an excellent diagnostic modality to confirm rudimentary horn pregnancies and to expedite appropriate management. PMID:26357563

  12. Ruptured rudimentary horn pregnancy at 25 weeks with previous vaginal delivery: a case report.

    PubMed

    Kanagal, Deepa V; Hanumanalu, Lokeshchandra C

    2012-01-01

    Unicornuate uterus with rudimentary horn occurs due to failure of complete development of one of the Mullerian ducts and incomplete fusion with the contralateral side. Pregnancy in a noncommunicating rudimentary horn is extremely rare and usually terminates in rupture during first or second trimester of pregnancy. Diagnosis of rudimentary horn pregnancy and its rupture in a woman with prior vaginal delivery is difficult. It can be missed in routine ultrasound scan and in majority of cases it is detected after rupture. It requires a high index of suspicion. We report a case of G2PlL1 with rupture rudimentary horn pregnancy at 25 weeks of gestation which was misdiagnosed as intrauterine pregnancy with fetal demise by ultrasound, and termination was attempted and the case was later referred to our hospital after the patient developed hemoperitoneum and shock with a diagnosis of rupture uterus. Laparotomy revealed rupture of right rudimentary horn pregnancy with massive hemoperitoneum. Timely laparotomy, excision of the horn, and blood transfusion saved the patient. PMID:22720180

  13. Ruptured Rudimentary Horn Pregnancy at 25 Weeks with Previous Vaginal Delivery: A Case Report

    PubMed Central

    Kanagal, Deepa V.; Hanumanalu, Lokeshchandra C.

    2012-01-01

    Unicornuate uterus with rudimentary horn occurs due to failure of complete development of one of the Mullerian ducts and incomplete fusion with the contralateral side. Pregnancy in a noncommunicating rudimentary horn is extremely rare and usually terminates in rupture during first or second trimester of pregnancy. Diagnosis of rudimentary horn pregnancy and its rupture in a woman with prior vaginal delivery is difficult. It can be missed in routine ultrasound scan and in majority of cases it is detected after rupture. It requires a high index of suspicion. We report a case of G2PlL1 with rupture rudimentary horn pregnancy at 25 weeks of gestation which was misdiagnosed as intrauterine pregnancy with fetal demise by ultrasound, and termination was attempted and the case was later referred to our hospital after the patient developed hemoperitoneum and shock with a diagnosis of rupture uterus. Laparotomy revealed rupture of right rudimentary horn pregnancy with massive hemoperitoneum. Timely laparotomy, excision of the horn, and blood transfusion saved the patient. PMID:22720180

  14. New perspectives in offshore wind energy.

    PubMed

    Failla, Giuseppe; Arena, Felice

    2015-02-28

    The design of offshore wind turbines is one of the most fascinating challenges in renewable energy. Meeting the objective of increasing power production with reduced installation and maintenance costs requires a multi-disciplinary approach, bringing together expertise in different fields of engineering. The purpose of this theme issue is to offer a broad perspective on some crucial aspects of offshore wind turbines design, discussing the state of the art and presenting recent theoretical and experimental studies. PMID:25583869

  15. 2014 Offshore Wind Market and Economic Analysis

    SciTech Connect

    Hamilton, Bruce

    2014-08-25

    The objective of this report is to provide a comprehensive annual assessment of the U.S. offshore wind market.This 3rd annual report focuses on new developments that have occurred in 2014. The report provides stakeholders with a reliable and consistent data source addressing entry barriers and U.S. competitiveness in the offshore wind market. Available for download are both the full report and the report's underlying data.

  16. New perspectives in offshore wind energy

    PubMed Central

    Failla, Giuseppe; Arena, Felice

    2015-01-01

    The design of offshore wind turbines is one of the most fascinating challenges in renewable energy. Meeting the objective of increasing power production with reduced installation and maintenance costs requires a multi-disciplinary approach, bringing together expertise in different fields of engineering. The purpose of this theme issue is to offer a broad perspective on some crucial aspects of offshore wind turbines design, discussing the state of the art and presenting recent theoretical and experimental studies. PMID:25583869

  17. Experimental verification of a real-time power curve for downregulated offshore wind power plants

    NASA Astrophysics Data System (ADS)

    Giebel, Gregor; Göcmen Bozkurt, Tuhfe; Sørensen, Poul; Rajczyk Skjelmose, Mads; Runge Kristoffersen, Jesper

    2015-04-01

    Wind farm scale experiments with wakes under downregulation have been initiated in Horns Rev wind farm in the frame of the PossPOW project (see posspow.dtu.dk). The experiments will be compared with the results of the calibrated GCLarsen wake model for real-time which is used not only to obtain real-time power curve but also to estimate the available power in wind farm level. Available (or Possible) Power is the power that a down-regulated (or curtailed) turbine or a wind power plant would produce if it were to operate in normal operational conditions and it is becoming more of particular interest due to increasing number of curtailment periods. Currently, the Transmission System Operators (TSOs) have no real way to determine exactly the available power of a down-regulated wind farm and the PossPOW project is addressing that need. What makes available power calculation interesting at the wind farm level is the change in the wake characteristics for different operational states. Even though the single turbine level available power is easily estimated, the sum of those signals from all turbines in a wind farm overestimates the power since the wake losses significantly decrease during curtailment. In order to calculate that effect, the turbine wind speed is estimated real-time from the produced power, the pitch angle and the rotor speed using a proximate Cp curve. A real-time wake estimation of normal operation is then performed and advected to the next downstream turbine, and so on until the entire wind farm is calculated. The estimation of the rotor effective wind speed, the parameterization of the GCLarsen wake model for real-time use (i.e., 1-sec data from Horns Rev and Thanet) and the details of the advection are the topic can be found in Göcmen et al. [1] Here we plan to describe the experiments using the Horns Rev wind farm and hopefully present the first validation results. Assuming similarity of the wind speeds between neighbouring rows of turbines, the

  18. Inhibition of the HIV Rev transactivator : a new target for therapeutic intervention.

    PubMed

    Heguy, A

    1997-01-01

    The viral transactivator Rev is essential for HIV replication, since it allows the nuclear export of unspliced and partially spliced viral mRNAs that encode the structural proteins. Rev is an RNA binding protein that interacts with a highly structured RNA element, the RRE, found within the envelope sequences. This viral protein also interacts with cellular proteins, termed nucleoporins, and acts as an adaptor between the viral mRNAs and the cellular nuclear export machinery. Both interactions are specific, and required for Rev function. Because of its crucial role in the HIV replication cycle, and its novel mechanism of action, Rev represents an ideal target for therapeutic intervention. This review describes the efforts towards Rev inhibition. Gene therapy approaches, including the expression of trans-dominant mutants and RNA decoys, as well as antisense therapies and small molecule inhibitors of Rev-RRE binding or Rev interaction with the cellular machinery will be discussed PMID:9206979

  19. Tsirelson bounds for generalized Clauser-Horne-Shimony-Holt inequalities

    SciTech Connect

    Wehner, Stephanie

    2006-02-15

    Quantum theory imposes a strict limit on the strength of nonlocal correlations. It only allows for a violation of the Clauser, Horne, Shimony, and Holt (CHSH) inequality up to the value 2{radical}(2), known as Tsirelson's bound. In this paper, we consider generalized CHSH inequalities based on many measurement settings with two possible measurement outcomes each. We demonstrate how to prove Tsirelson bounds for any such generalized CHSH inequality using semidefinite programming. As an example, we show that for any shared entangled state and observables X{sub 1},...,X{sub n} and Y{sub 1},...,Y{sub n} with eigenvalues {+-}1 we have |++++{center_dot}{center_dot}{center_dot}+-|{<=}2n cos[{pi}/(2n)]. It is well known that there exist observables such that equality can be achieved. However, we show that these are indeed optimal. Our approach can easily be generalized to other inequalities for such observables.

  20. Chronic myelogenous leukemia in a great horned owl (Bubo virginianus).

    PubMed

    Wiley, Jennifer L; Whittington, Julia K; Wilmes, Christine M; Messick, Joanne B

    2009-03-01

    A free-ranging adult female great horned owl (Bubo virginianus) was presented to the Wildlife Medical Clinic at the University of Illinois after being observed with anorexia and decreased activity. A severe leukocytosis (212 400 cells/microl), primarily comprised of mature heterophils, was found at presentation. Results of various diagnostic tests including radiographs, Chlamydophila serologic testing, measurement of Aspergillus antibody and antigen titers, plasma protein electrophoresis, fecal culture and acid-fast staining, coelioscopy, endoscopy, tracheoscopy, exploratory coelomotomy, nuclear scintigraphy, tissue cultures, bone marrow biopsy, and histopathology revealed no underlying cause for the persistent leukocytosis. No response to treatment with antibiotics or antifungal agents was observed, although a transient, significant decrease in the leukocyte count (6200 cells/microl) was observed after treatment with fenbendazole. A presumptive diagnosis of chronic myelogenous leukemia was made based on 3 factors: disease duration of greater than 3 months, a lack of identifiable foci of inflammation, and a lack of response to conventional therapy. The diagnosis was confirmed based on postmortem examination and testing 177 days after initial presentation. PMID:19530405

  1. Solid Micro Horn Array (SMIHA) for Acoustic Matching

    NASA Technical Reports Server (NTRS)

    Sherrit, S.; Bao, X.; Bar-Cohen, Y.

    2008-01-01

    Transduction of electrical signals to mechanical signals and vice-versa in piezoelectric materials is controlled by the material coupling coefficient. In general in a loss-less material the ratio of energy conversion per cycle is proportional to the square of the coupling coefficient. In practical transduction however the impedance mismatch between the piezoelectric material and the electrical drive circuitry or the mechanical structure can have a significant impact on the power transfer. This paper looks at novel methods of matching the acoustic impedance of structures to the piezoelectric material in an effort to increase power transmission and efficiency. In typical methods the density and acoustic velocity of the matching layer is adjusted to give good matching between the transducer and the load. The approach discussed in this paper utilizes solid micro horn arrays in the matching layer which channel the stress and increase the strain in the layer. This approach is found to have potential applications in energy harvesting, medical ultrasound and in liquid and gas coupled transducers.

  2. Metamorphosis and Gonad Maturation in the Horn Fly Haematobia irritans

    PubMed Central

    Basso, Alicia L; Forneris, Natalia S.; Filiberti, Adrián; Argaraña, Carlos E.; Rabossi, Alejandro; Quesada-Allué, Luis A.

    2011-01-01

    The bloodsucking horn fly, Haematobia irritans (L.) (Diptera: Muscidae), is one of the most damaging pests of pasture cattle in many areas of the world. Both male and female imagoes spend their adult stage on the host, while immature stages develop in dung. Our goal was to determine if the progress of H. irritans gonad maturation can be correlated with eye and cuticle pigmentation events that occur during development of the imago within the puparium. The progression of germline cell divisions in immature gonads was analyzed from the beginning of the third larval instar (48 hours after egg hatch) until imago ecdysis. In the developing male larval gonad, meiosis began 72 hours after egg hatch, whereas in females oogonia were premeiotic at 72 hours. Meiosis was not detected in females until the mid-pharate adult stage, 120 hours after puparium formation. Therefore, gonad maturation in females appears to be delayed 144 hours with respect to that in males. In the stages within the puparium, the timing of germline cell division events was correlated with the progress of pigmentation of the eyes and cuticle as external markers. PMID:22957976

  3. [Multiple bladder diverticula caused by occipital horn syndrome].

    PubMed

    Legros, L; Revencu, N; Nassogne, M-C; Wese, F-X; Feyaerts, A

    2015-11-01

    We report on the case of a child who presented with recurrent, multiple, and voluminous bladder diverticula. Bladder diverticula are defined as a herniation of the mucosa through the bladder muscle or the detrusor. Causes are numerous and diverticula can be classified into primary congenital diverticula (para-ureteral - or Hutch diverticula - and posterolateral diverticula); secondary diverticula (resulting from chronic mechanical obstruction or from neurological disease; and diverticula secondary to connective tissue or muscle fragility. The latter is seen in disease entities such as prune belly syndrome, Ehlers-Danlos syndrome, cutis laxa syndrome, OHS (occipital horn syndrome), Menkes disease, and Williams-Beuren syndrome. In this patient, the cause of these diverticula was OHS, a genetic, recessive X-chromosome-linked syndrome, responsible for abnormal tissue caused by a disorder in copper metabolism. This case reminds us of the importance of pushing the diagnostic workup when presented with multiple and/or large bladder diverticula, and in particular to search for rare malformation syndromes after exclusion of an obstacle. PMID:26386812

  4. Norwegian Offshore Stratigraphic Lexicon (NORLEX)

    NASA Astrophysics Data System (ADS)

    Gradstein, Felix M.; Hammer, Oyvind; Brunstad, Harald; Charnock, Mike; Hellem, Terje; Sigve Lervik, Kjell; Anthonissen, Erik

    2010-05-01

    The Norwegian Offshore Stratigraphic Lexicon (NORLEX) provides a relational stratigraphic database for the North Sea, Norwegian Sea, Barents Sea and Svalbard. Both regional lithostratigraphy and biostratigraphy are being substantially updated, following guidelines laid out in the International Stratigraphic Guide. The main body of information developed is available as a petroleum consortium (oracle-style) database, and the new lithostratigraphic definitions as a public domain (paper) document. NORLEX is presented as a browsing website via the internet at http://www.nhm.uio.no/norlex. Seismic cross-sections, core photographs, well logs, field outcrops, microfossil occurrences and other vital attributes are relationally cross-linked. In addition, there are menus for instantly finding updated formation and member tops or microfossil events in all wells, plus a map contouring routine for unit thicknesses and depths. Several new initiatives will expand data and user coverage: 1. Overhaul of Mesozoic stratigraphy, especially Triassic and Cretaceous, in the Barents Sea. 2. Coverage of East Greenland 3. Linkage to UK and Belgium and The Netherlands surface and subsurface stratigraphy 4. Creation of a Sequence Stratigraphic Framework for specific regions. 5. A national microfossil atlas to support zonations 6. Tight linkage to the basin datapacks in TimeScaleCreator Pro, as developed for Australia, New Zealand, Brasil, Gulf of Mexico, Canada and Russia. NORLEX may thus evolve to become STRATLEX, covering many basin regions.

  5. Medical evacuations from offshore structures.

    PubMed

    Norman, J N; Ballantine, B N; Brebner, J A; Brown, B; Gauld, S J; Mawdsley, J; Roythorne, C; Valentine, M J; Wilcock, S E

    1988-09-01

    A retrospective study was carried out on medical evacuations from the installations of four major oil or gas producing companies, or both, operating offshore on the United Kingdom continental shelf. The study covered 1976-84 during which 2162 evacuations were recorded. Of these, 137 (7.7%) required the use of a chartered helicopter. In the earlier years of the study there were substantially more injuries sustained than episodes of illness recorded but from 1980 onwards the cases of illness equalled those of injury. Using the International Classification of Diseases, the digestive system was responsible for most evacuations for illness and of those, about half (115 evacuations) were for dental problems. Suspected fractures were responsible for about one third of those evacuated for an injury but injuries of hands and eye conditions were particularly common, accounting for 25% of all evacuations. As the age of the evacuee increased the proportion of evacuations for injury decreased and that for illness increased. The mean age for evacuation for injury was 28.3 years and for illness 34.4 years. Few evacuations were required for those aged over 45. PMID:3179237

  6. Offshore oil and the coastline

    NASA Astrophysics Data System (ADS)

    Bell, Peter M.

    A radical, accelerated 5-year plan to offer 875 million acres (of which 20 million could actually be leased for oil and gas extraction purposes) on the outer continental shelf (OCS) could result in the release of large volumes of drilling wastes and spillage (Environ. Sci. Tech., Nov. 1981). The actual leasing, under the 5-year plan proposed by Secretary of the Interior James G. Watt, could amount to 4-5 million acres per year—about 10 times as much, on the average, as had been leased over the past 25 years. Regulations on the environmental effects may be less complicated yet more effective in that impact statements will cover large areas instead of the tract-by-tract statements now required. A number of the new offshore leasing areas, for example, the Alaska Coast (Cook Inlet, Beaufort Bay, Gulf of Alaska), the Blake Plateau and Baltimore Canyon, and the Georges Bank, are extremely valuable in terms of renewable resources and potentially fragile in terms of environmental conditions. Fishing interests in these areas have produced considerable controversy over the planned sale of petroleum rights.

  7. Arctic & Offshore Technical Data System

    Energy Science and Technology Software Center (ESTSC)

    1990-07-01

    AORIS is a computerized information system to assist the technology and planning community in the development of Arctic oil and gas resources. In general, AORIS is geographically dependent and, where possible, site specific. The main topics are sea ice, geotechnology, oceanography, meteorology, and Arctic engineering, as they relate to such offshore oil and gas activities as exploration, production, storage, and transportation. AORIS consists of a directory component that identifies 85 Arctic energy-related databases and tellsmore » how to access them; a bibliographic/management information system or bibliographic component containing over 8,000 references and abstracts on Arctic energy-related research; and a scientific and engineering information system, or data component, containing over 800 data sets, in both tabular and graphical formats, on sea ice characteristics taken from the bibliographic citations. AORIS also contains much of the so-called grey literature, i.e., data and/or locations of Arctic data collected, but never published. The three components are linked so the user may easily move from one component to another. A generic information system is provided to allow users to create their own information systems. The generic programs have the same query and updating features as AORIS, except that there is no directory component.« less

  8. Analysis of a disk-on-rod surface wave element inside a corrugated horn using the mode-matching technique

    NASA Technical Reports Server (NTRS)

    Chen, J. C.

    1995-01-01

    A disk-on-rod inside a corrugated horn is one of the horn configurations for dual-frequency or wide-band operation. A mode-matching analysis method is described. A disk-on-rod inside a corrugated horn is represented as a series of coaxial waveguide sections and circular waveguide sections connected to each other. Three kinds of junctions need to be considered: coaxial-to-coaxial, coaxial-to-circular, and circular-to-circular. A computer program was developed to calculate the scattering matrix and the radiation pattern of a disk-on-rod inside a corrugated horn. The software as verified by experiment, and good agreement between calculation and measurement was obtained. The disk-on-rod inside a corrugated horn design gives an option to the Deep Space Network dual-frequency operation system, which currently is a two-horn/one-dichroic plate system.

  9. 78 FR 27913 - Revision of Crane Regulation Standards for Mobile Offshore Drilling Units (MODUs), Offshore...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ...The Coast Guard proposes to revise regulations related to the design, certification, inspection, and testing of cranes. These regulations apply to cranes installed on Mobile Offshore Drilling Units (MODUs), Offshore Supply Vessels (OSVs), and floating Outer Continental Shelf (OCS) facilities. This revision would update industry standards incorporated by reference with more recent versions,......

  10. Milk production traits of beef cows as affected by horn fly count and sire breed type.

    PubMed

    Mays, A R; Brown, M A; von Tunglen, D L; Rosenkrans, C F

    2014-03-01

    Horn fly infestations negatively impact economic traits of beef cattle. Our objective was to determine the impact of horn flies on beef cattle milk yield and quality. Cows (n = 53) were derived from Brangus dams and sired by Bonsmara (n = 7), Brangus (n = 13), Charolais (n = 8), Gelbvieh (n = 5), Hereford (n = 12), and Romosinuano (n = 8) bulls. Horn fly counts and estimates of milk yield and quality were recorded monthly from May through October on individual cows. Data for milk yield and quality and horn fly count were analyzed by mixed model least squares using a linear model including sire breed, cow in sire breed, month, and month × sire breed. Effects of horn fly count on milk yield and quality were estimated by analysis of covariance using log horn fly count and log horn fly count × sire breed. Horn fly counts varied by month (P < 0.0001), with lowest population recorded in May (99 flies) and peaked in August (520 flies). Bonsmara and Gelbvieh sired cows had greater (P < 0.05) milk yield compared to Hereford sired cows (8.75 and 8.62 vs. 6.02 kg/d, respectively). Milk yield from Charolais, Romosinuano, and Brangus sired cows was intermediate (7.28, 7.00, and 7.06 kg/d, respectively). Regression of milk yield on fly count differed (P < 0.05) among sire breeds. Milk yield was reduced (P < 0.05) by 0.99 and 0.64 kg/d per unit increase in log horn fly count in Gelbvieh and Bonsmara sired cows. Regression coefficient for milk yield on log horn fly count was reduced (P < 0.01) in Gelbvieh sired cows when compared with Brangus, Charolais, Hereford, and Romosinuano sired cows, and coefficients for Bonsmara sired cows were reduced (P < 0.05) in comparison to Brangus sired cows. Increases in log fly count were associated with decreases (P < 0.05) in milk fat, solids-not-fat, and milk urea nitrogen. Milk yield was reduced (P < 0.05) by increased fly numbers depending on month of lactation and interaction with log horn fly count. In May, June, and July milk yield was

  11. Targeted cleavage of HIV RRE RNA by Rev-coupled transition metal chelates.

    PubMed

    Joyner, Jeff C; Cowan, J A

    2011-06-29

    A series of compounds that target reactive metal chelates to the HIV-1 Rev response element (RRE) mRNA have been synthesized. Dissociation constants and chemical reactivity toward HIV RRE RNA have been determined and evaluated in terms of reduction potential, coordination unsaturation, and overall charge associated with the metal-chelate-Rev complex. Ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), diethylenetriaminepentaacetic acid (DTPA), and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) were linked to a lysine side chain of a Rev-derived peptide by either EDC/NHS or isothiocyanate coupling. The resulting chelate-Rev (EDTA-Rev, DTPA-Rev, NTA-Rev, and DOTA-Rev) conjugates were used to form coordination complexes with Fe(2+), Co(2+), Ni(2+), and Cu(2+) such that the arginine-rich Rev peptide could mediate localization of the metal chelates to the Rev peptide's high-affinity mRNA binding partner, RRE stem loop IIB. Metal complexes of the extended peptides GGH-Rev and KGHK-Rev, which also contain N-terminal peptidic chelators (ATCUN motifs), were studied for comparison. A fluorescence titration assay revealed high-affinity RRE RNA binding by all 22 metal-chelate-Rev species, with K(D) values ranging from ~0.2 to 16 nM, indicating little to no loss of RNA affinity due to the coupling of the metal chelates to the Rev peptide. Dissociation constants for binding at a previously unobserved low-affinity site are also reported. Rates of RNA modification by each metal-chelate-Rev species were determined and varied from ~0.28 to 4.9 nM/min but were optimal for Cu(2+)-NTA-Rev. Metal-chelate reduction potentials were determined and varied from -228 to +1111 mV vs NHE under similar solution conditions, allowing direct comparison of reactivity with redox thermodynamics. Optimal activity was observed when the reduction potential for the metal center was poised between those of the two principal co-reagents for metal-promoted formation of

  12. Rehabilitation studies and recovery of a once lifeless estuary: the Golden Horn.

    PubMed

    Yüksek, A; Okuş, E; Yilmaz, N

    2005-01-01

    Within this study fluctuations in biodiversity of the Golden Horn from past to present are evaluated. Limited studies and observations dating back to 60 years ago pointed out the importance of the Golden Horn as a fishery. Unfortunately, in accordance with increase in unplanned settlements and industry around the Golden Horn in the 1960s, pollution stress became a demanding factor for this unique environment, affecting biodiversity adversely. Preliminary studies in the 1990s indicated survival of only a couple of pollution-resistant species, at the relatively cleaner outer estuary. Following intensification of "still ongoing" rehabilitation studies in 1998, a remarkable day-by-day recovery in marine life has began, in regard to improvements in water quality. Surveys conducted in 2002 using SCUBA, documented the level of diversification of life at the Golden Horn. Extended till Haliç Bridge, all appropriate substratums were intensely covered by macrobenthic forms and particularly filter feeders dominated the plankton-rich ecosystem. Detection of seahorses at the inner-middle parts of the estuary, in addition to numerous fish, invertebrate and macroalgae species, clearly depicted the level of recovery and change in the ecosystem. All results support the existence of a dynamic biological life at the Golden Horn, improving considerably with rehabilitation studies. Achieving the diversity of the 1940s is not possible, since the Black and Marmara seas, highly influencing water quality in the Golden Horn are also suffering from anthropogenic impacts and are far beyond their rich diversity in the 1940s. However, it is obvious that ecosystems should recover when mankind gave a chance to them. Recovery of the recently lifeless Golden Horn in such a short period of time is a very good example. PMID:16114614

  13. The Nuclear Receptor Rev-erbα Controls Circadian Thermogenic Plasticity

    PubMed Central

    Gerhart-Hines, Zachary; Everett, Logan J.; Loro, Emanuele; Briggs, Erika R.; Bugge, Anne; Hou, Catherine; Ferrara, Christine; Seale, Patrick; Pryma, Daniel A.; Khurana, Tejvir S.; Lazar, Mitchell A.

    2013-01-01

    Circadian oscillation of body temperature is a basic, evolutionary-conserved feature of mammalian biology1. Additionally, homeostatic pathways allow organisms to protect their core temperatures in response to cold exposure2. However, the mechanism responsible for coordinating daily body temperature rhythm and adaptability to environmental challenges is unknown. Here we show that the nuclear receptor Rev-erbα, a powerful transcriptional repressor, links circadian and thermogenic networks through the regulation of brown adipose tissue (BAT) function. Mice exposed to cold fare dramatically better at 5 AM (Zeitgeber time 22) when Rev-erbα is barely expressed than at 5 PM (ZT10) when Rev-erbα is abundant. Deletion of Rev-erbα markedly improves cold tolerance at 5 PM, indicating that overcoming Rev-erbα-dependent repression is a fundamental feature of the thermogenic response to cold. Physiological induction of uncoupling protein 1 (UCP1) by cold temperatures is preceded by rapid down-regulation of Rev-erbα in BAT. Rev-erbα represses UCP1 in a brown adipose cell-autonomous manner and BAT UCP1 levels are high in Rev-erbα-null mice even at thermoneutrality. Genetic loss of Rev-erbα also abolishes normal rhythms of body temperature and BAT activity. Thus, Rev-erbα acts as a thermogenic focal point required for establishing and maintaining body temperature rhythm in a manner that is adaptable to environmental demands. PMID:24162845

  14. The nuclear receptor Rev-erbα controls circadian thermogenic plasticity.

    PubMed

    Gerhart-Hines, Zachary; Feng, Dan; Emmett, Matthew J; Everett, Logan J; Loro, Emanuele; Briggs, Erika R; Bugge, Anne; Hou, Catherine; Ferrara, Christine; Seale, Patrick; Pryma, Daniel A; Khurana, Tejvir S; Lazar, Mitchell A

    2013-11-21

    Circadian oscillation of body temperature is a basic, evolutionarily conserved feature of mammalian biology. In addition, homeostatic pathways allow organisms to protect their core temperatures in response to cold exposure. However, the mechanism responsible for coordinating daily body temperature rhythm and adaptability to environmental challenges is unknown. Here we show that the nuclear receptor Rev-erbα (also known as Nr1d1), a powerful transcriptional repressor, links circadian and thermogenic networks through the regulation of brown adipose tissue (BAT) function. Mice exposed to cold fare considerably better at 05:00 (Zeitgeber time 22) when Rev-erbα is barely expressed than at 17:00 (Zeitgeber time 10) when Rev-erbα is abundant. Deletion of Rev-erbα markedly improves cold tolerance at 17:00, indicating that overcoming Rev-erbα-dependent repression is a fundamental feature of the thermogenic response to cold. Physiological induction of uncoupling protein 1 (Ucp1) by cold temperatures is preceded by rapid downregulation of Rev-erbα in BAT. Rev-erbα represses Ucp1 in a brown-adipose-cell-autonomous manner and BAT Ucp1 levels are high in Rev-erbα-null mice, even at thermoneutrality. Genetic loss of Rev-erbα also abolishes normal rhythms of body temperature and BAT activity. Thus, Rev-erbα acts as a thermogenic focal point required for establishing and maintaining body temperature rhythm in a manner that is adaptable to environmental demands. PMID:24162845

  15. REV3L modulates cisplatin sensitivity of non-small cell lung cancer H1299 cells.

    PubMed

    Wang, Wenjie; Sheng, Wenjiong; Yu, Chenxiao; Cao, Jianping; Zhou, Jundong; Wu, Jinchang; Zhang, Huojun; Zhang, Shuyu

    2015-09-01

    Lung cancer remains the leading cause of cancer-related mortality worldwide and non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all cases of lung cancer. Cisplatin plays a significant role in the management of human lung cancer. Translesion DNA synthesis (TLS) is involved in DNA damage repair. DNA polymerase ζ (Pol ζ) is able to mediate the DNA replication bypass of DNA damage, which is suggested to be involved in chemoresistance. REV3L is the catalytic subunit of Pol ζ. Due to its critical role in translesion DNA synthesis, whether REV3L modulates cisplatin response in NSCLC cells remains unknown. In this study, REV3L overexpression and silencing H1299 cell lines were established. The reports showed that cisplatin induced the expression of REV3L by recruiting Sp1 to its promoter. Similar results were obtained when the ability of the cells to express luciferase from a platinated plasmid was measured. Co-transfection of the reporter with the REV3L overexpression vector or REV3L plus REV7L significantly enhanced the reporter activity. Nuclear condensation and fragmentation of shRNA-REV3L H1299 cells were more pronounced than shRNA-NC H1299 cells after cisplatin exposure, indicating that REV3L overexpression abolished cisplatin-induced DNA damage. Moreover, a forced expression of REV3L conferred the resistance of H1299 cells to cisplatin, whereas the knockdown of REV3L sensitized cisplatin efficacy in H1299 cells. Taken together, we demonstrated that inhibition of REV3L sensitized lung cancer H1299 cells to cisplatin treatment. Thus, REV3L may be a novel target for the chemotherapy of NSCLC. PMID:26165320

  16. Vegetation change, malnutrition and violence in the Horn of Africa

    NASA Astrophysics Data System (ADS)

    Rowhani, P.; Degomme, O.; Linderman, M.; Guha-Sapir, D.; Lambin, E.

    2008-12-01

    In certain circumstances, climate change in association with a broad range of social factors may increase the risk of famines and subsequently, violent conflict. The impacts of climate change on society will be experienced both through changes in mean conditions over long time periods and through increases in extreme events. Recent studies have shown the historical effects of long term climate change on societies and the importance of short term climatic triggers on armed conflict. However, most of these studies are at the state level ignoring local conditions. Here we use detailed information extracted from wide-swath satellite data (MODIS) to analyze the impact of climate variability change on malnutrition and violent conflict. More specifically, we perform multivariate logistic regression analysis in order to explain the geographical distribution of malnutrition and conflict in the Horn of Africa on a sub-national level. This region, constituted by several unstable and poor states, has been affected by droughts, floods, famines, and violence in the past few years. Three commonly used nutrition and mortality indicators are used to characterize the health situation (CE-DAT database). To map violence we use the georeferenced Armed Conflicts dataset developed by the Center for the Study of Civil War. Explanatory variables include several socio-economic variables and environmental variables characterizing land degradation, vegetation activity, and interannual variability in land-surface conditions. First results show that interannual variability in land-surface conditions is associated with malnutrition but not with armed conflict. Furthermore, land degradation seems not to be associated with either malnutrition or armed conflict.

  17. New OBS network deployment offshore Ireland

    NASA Astrophysics Data System (ADS)

    Le Pape, Florian; Bean, Chris; Craig, David; Jousset, Philippe; Horan, Clare; Hogg, Colin; Donne, Sarah; McCann, Hannah; Möllhoff, Martin; Kirk, Henning; Ploetz, Aline

    2016-04-01

    With the presence of the stormy NE Atlantic, Ireland is ideally located to investigate further our understanding of ocean generated microseisms and use noise correlation methods to develop seismic imaging in marine environments as well as time-lapse monitoring. In order to study the microseismic activity offshore Ireland, 10 Broad Band Ocean Bottom Seismographs (OBSs) units including hydrophones have been deployed in January 2016 across the shelf offshore Donegal and out into the Rockall Trough. This survey represents the first Broadband passive study in this part of the NE Atlantic. The instruments will be recovered in August 2016 providing 8 months worth of data to study microseisms but also the offshore seismic activity in the area. One of the main goal of the survey is to investigate the spatial and temporal distributions of dominant microseism source regions, close to the microseism sources. Additionally we will study the coupling of seismic and acoustic signals at the sea bed and its evolution in both the deep water and continental shelf areas. Furthermore, the survey also aims to investigate further the relationship between sea state conditions (e.g. wave height, period), seafloor pressure variations and seismic data recorded on both land and seafloor. Finally, the deployed OBS network is also the first ever attempt to closely monitor local offshore earthquakes in Ireland. Ireland seismicity although relatively low can reduce slope stability and poses the possibility of triggering large offshore landslides and local tsunamis.

  18. Operational management of offshore energy assets

    NASA Astrophysics Data System (ADS)

    Kolios, A. J.; Martinez Luengo, M.

    2016-02-01

    Energy assets and especially those deployed offshore are subject to a variety of harsh operational and environmental conditions which lead to deterioration of their performance and structural capacity over time. The aim of reduction of CAPEX in new installations shifts focus to operational management to monitor and assess performance of critical assets ensuring their fitness for service throughout their service life and also to provide appropriate and effective information towards requalification or other end of life scenarios, optimizing the OPEX. Over the last decades, the offshore oil & gas industry has developed and applied various approaches in operational management of assets through Structural Health and Condition Monitoring (SHM/CM) systems which can be, at a certain level, transferable to offshore renewable installations. This paper aims to highlight the key differences between offshore oil & gas and renewable energy assets from a structural integrity and reliability perspective, provide a comprehensive overview of different approaches that are available and applicable, and distinguish the benefits of such systems in the efficient operation of offshore energy assets.

  19. A framework for offshore vendor capability development

    NASA Astrophysics Data System (ADS)

    Yusuf Wibisono, Yogi; Govindaraju, Rajesri; Irianto, Dradjad; Sudirman, Iman

    2016-02-01

    Offshore outsourcing is a common practice conducted by companies, especially in developed countries, by relocating one or more their business processes to other companies abroad, especially in developing countries. This practice grows rapidly owing to the ease of accessing qualified vendors with a lower cost. Vendors in developing countries compete more intensely to acquire offshore projects. Indonesia is still below India, China, Malaysia as main global offshore destinations. Vendor capability is among other factors that contribute to the inability of Indonesian vendor in competing with other companies in the global market. Therefore, it is essential to study how to increase the vendor's capability in Indonesia, in the context of global offshore outsourcing. Previous studies on the vendor's capability mainly focus on capabilities without considering the dynamic of capabilities due to the environmental changes. In order to be able to compete with competitors and maintain the competitive advantage, it is necessary for vendors to develop their capabilities continuously. The purpose of this study is to develop a framework that describes offshore vendor capability development along the client-vendor relationship stages. The framework consists of three main components, i.e. the stages of client-vendor relationship, the success of each stage, and the capabilities of vendor at each stage.

  20. Offshore oil gas trends in ROVs tooling

    SciTech Connect

    Jacobson, J.R. )

    1994-04-01

    The ROVs that operate in today's offshore environment bear little or no resemblance to those which first began supporting the oil and gas work requirements less than 15 years ago. In that short span of time, an explosion of subsea technology has occurred, rendering older equipment obsolete and expanding subsea remote intervention capabilities beyond the horizon of intervention tasks originally envisioned. Today's offshore work ROVs employ the latest in robotics, fiver optics, acoustics, video, and computer technologies, and routinely achieve better than 90 percent operational availability. Leading offshore ROV operations companies have demonstrated less than 1 percent down-time over thousands of hours of operation. As the offshore oil and gas market evolves, the ever-expanding capabilities of the work ROV plays a major role in shaping the operational concepts employed in subsea oil and gas field exploration, development, and production. This paper explores the capabilities of available ROV systems in use offshore today, the economic trends driving ROV technology development, and the new trends in the employment of ROVs and their associated sensors and tooling systems.

  1. Surgery for malposition of the great arteries: the REV procedure.

    PubMed

    Di Carlo, Duccio; Lecompte, Yves; Tomasco, Biagio; Cohen, Laurence; Vouhé, Pascal

    2009-01-01

    The REV procedure was introduced in 1980 to treat transposition of the great arteries with ventricular septal defect (VSD) and pulmonary stenosis and malpositions similar to transposition of the great arteries (TGA). It aims at overcoming the drawbacks and limitations of the classic Rastelli operation, such as subaortic stenosis, late ventricular deterioration, arrhythmias and sudden death. In particular, the resection of the infundibular septum allows for the placement of a straighter, smaller ventricular patch, bulging much less in the right ventricular cavity. The extensive mobilization of the main pulmonary branches permits a direct connection with the right ventricular incision, thus avoiding the need for an extracardiac conduit. The procedure was performed in 205 patients as of December 2003 with 12% hospital mortality. Patients for whom the Rastelli operation would have been contraindicated, were accepted for REV repair. Late results show a clear improvement over those reported with the Rastelli operation in terms of overall survival (85% at 25-year follow-up interval) and prevalence of reoperation for right ventricular obstruction. Obstruction of the left ventricle-to-aorta tunnel is exceedingly rare. This operation should be considered the gold standard when new surgical options are considered for this complex form of transpositions/malpositions of the great arteries. PMID:24412824

  2. The 24 GHz measurements of 2.2 lambda conical horn antennas illuminating a conducting sheet

    NASA Technical Reports Server (NTRS)

    Cross, A. E.; Marshall, R. E.; Hearn, C. P.; Neece, R. T.

    1993-01-01

    Monostatic reflection-coefficient magnitude, absolute value of Gamma, measurements occurring between a radiating horn and a metal reflecting plate are presented for a family of three 2.2 lambda diameter conical horn antennas. The three horns have different aperture phase deviations: 6 deg, 22.5 deg, and 125 deg. Measurements of the magnitude of absolute value of Gamma as a function of horn-plate separation (d) extend from an effective antenna aperture short (d = O) to beyond the far-field boundary (d = 2D(sup 2)/lambda, where D is the antenna diameter). Measurement data are presented with various physical environments for each of the horns. Measured scalar data are compared with theoretical data from two models, a numerical model for a circular waveguide aperture in a ground plane and a scalar diffraction theory model. This work was conducted in support of the development effort for a spaceborne multifrequency microwave reflectometer designed to accurately determine the distance from a space vehicle's surface to a reflecting plasma boundary. The metal reflecting plate was used to simulate the RF reflectivity of a critically dense plasma. The resulting configuration, a ground plane mounted aperture facing a reflecting plane in close proximity, produces a strong interaction between the ground plane and the reflecting plate, especially at integral half-wavelength separations. The transition coefficient is characterized by large amplitude variations.

  3. A Low-cost 21 cm Horn-antenna Radio Telescope for Education and Outreach

    NASA Astrophysics Data System (ADS)

    Patel, Nimesh A.; Patel, Rishi N; Kimberk, Robert S; Test, John H; Krolewski, Alex; Ryan, James; Karkare, Kirit S; Kovac, John M; Dame, Thomas M.

    2014-06-01

    Small radio telescopes (1-3m) for observations of the 21 cm hydrogen line are widely used for education and outreach. A pyramidal horn was used by Ewen & Purcell (1951) to first detect the 21cm line at Harvard. Such a horn is simple to design and build, compared to a parabolic antenna which is usually purchased ready-made. Here we present a design of a horn antenna radio telescope that can be built entirely by students, using simple components costing less than $300. The horn has an aperture of 75 cm along the H-plane, 59 cm along the E-plane, and gain of about 20 dB. The receiver system consists of low noise amplifiers, band-pass filters and a software-defined-radio USB receiver that provides digitized samples for spectral processing in a computer. Starting from construction of the horn antenna, and ending with the measurement of the Galactic rotation curve, took about 6 weeks, as part of an undergraduate course at Harvard University. The project can also grow towards building a two-element interferometer for follow-up studies.

  4. Pregnancy in the Rudimentary Uterine Horn: Case report of an unusual presentation.

    PubMed

    Ambusaidi, Qamariya; Jha, Chitra

    2014-02-01

    A unicornuate uterus with a rudimentary horn is a uterine anomaly resulting from the incomplete development of one of the Müllerian ducts and an incomplete fusion with the contralateral side. Pregnancy in a rudimentary horn of the uterus is a rare clinical condition with a reported incidence of 1 in 100,000 to 140,000 pregnancies. Usually the diagnosis is missed and may present as an emergency with haemoperitoneum. The standard treatment is the surgical excision of the horn. A gravida 2, para 1 patient presented at 23 weeks' gestation with fetal demise. Repeated failed attempts at induction of labour raised the suspicion of an abnormally located pregnancy which was confirmed by magnetic resonance imaging. She underwent a laparotomy with right rudimentary horn excision. The final diagnosis of a non-communicating rudimentary horn pregnancy was made intraoperatively and was confirmed by histopathology. This case highlights the importance of an early ultrasound in detecting uterine anomalies and the need for high clinical suspicion. PMID:24516746

  5. CONCEPT DESIGN OF THE TARGET/HORN SYSTEM FOR THE BNL NEUTRINO OSCILLATION EXPERIMENT.

    SciTech Connect

    SIMOS,N.KIRK,H.KAHN,S.CARROL,A.LUDEWIG,H.WENG,W.T.DIWAN,M.RAPARIA,D.MCDONALD,K.EVANGELAKIS,G.

    2003-05-12

    The design concept for the integration of the target and the focusing horn system for the proposed BNL neutrino oscillation experiment is described in this paper. Also presented are issues associated with the functionality and thermo-mechanical response of the selected target intercepting the 28 GeV protons of the 1 MW upgraded AGS beam, the loading and mechanical response of the focusing horn subjected to high currents and energy deposited due to beam/target interaction, the integration of the two systems, and the heat removal schemes. The proposed target intercepts the 8.9 x 10{sup 13}, 28 GeV protons with a 2.5 Hz cycle time over a spot that encloses the 3{sigma} of the beam. In the baseline. design the inner conductor of the aluminum horn encloses the target while allowing for an annular space for forced cooling. Approximately 250 kA pulse of current of 20{micro}s duration will flow through the horn at 2.5 Hz repetition rate inducing high compressive forces, vibration and heat. The paper addresses these issues of horn mechanical response, heat removal scenario, and useful life estimation including radiation damage.

  6. Federal Offshore Statistics, 1993. Leasing, exploration, production, and revenue as of December 31, 1993

    SciTech Connect

    Francois, D.K.

    1994-12-31

    This document contains statistical data on the following: federal offshore lands; offshore leasing activity and status; offshore development activity; offshore production of crude oil and natural gas; federal offshore oil and natural gas sales volume and royalties; revenue from federal offshore leases; disbursement of federal offshore revenue; reserves and resource estimates of offshore oil and natural gas; oil pollution in US and international waters; and international activities and marine minerals. A glossary is included.

  7. Solar power satellite offshore rectenna study

    NASA Technical Reports Server (NTRS)

    1980-01-01

    Offshore rectennas are feasible and cost competitive with land rectennas but the type of rectenna suitable for offshore use is quite different from that specified in the present reference system. A nonground plane design minimizes the weight and greatly reduces the number of costly support towers. This perferred design is an antenna array consisting of individually encapsulated dipoles with reflectors or tagis supported on feed wires. Such a 5 GW rectenna could be built at a 50 m water depth site to withstand hurricane, winter storm, and icing conditions for a one time cost of $5.7 billion. Subsequent units would be about 1.3 less expensive. More benign and more shallow water sites would result in substantially lower costs. The major advantage of an offshore rectenna is the removal of microwave radiation from populated areas.

  8. Propofol Produces Immobility via Action in the Ventral Horn of the Spinal Cord by a GABAergic Mechanism

    PubMed Central

    Kungys, Gudrun; Kim, JongBun; Jinks, Steven L.; Atherley, Richard J.; Antognini, Joseph F.

    2011-01-01

    Background We investigated the actions of propofol and isoflurane on nociceptive responses of neurons in the spinal cord. Methods We determined nociceptive responses of lumbar neurons in the dorsal horn (<1200 μm) and ventral horn (>1200 μm) of decerebrate rats before and during propofol (1 effective dose, ED50) or isoflurane (1 minimum alveolar concentration) anesthesia. During recording of ventral horn neurons, we administered picrotoxin by infusion to determine whether isoflurane and propofol differed in their effects at the gamma amminobutyric acid (GABA) Type A receptors. We also determined whether decerebration altered propofol requirements to produce immobility. Results Decerebration did not affect propofol requirements. The ED50 for propofol was 497 ± 58 μg/kg/min in intact rats and 420 ± 65 μg/kg/min in decerebrated rats (p>0.05), with corresponding propofol blood concentrations of 8.1 ± 1.1 μg/ml and 7.3 ± 1.1 μg/ml, respectively (p>0.05). Propofol did not significantly depress dorsal horn neurons, but isoflurane depressed the responses to 56% of control (p<0.05). Propofol depressed ventral horn neurons to 47% of control, whereas isoflurane depressed ventral horn neurons to 20% of control. Picrotoxin significantly reversed the depressant effect of propofol on ventral horn neuronal responses (79% of control, not significantly different from control). Picrotoxin, however, had no effect on isoflurane’s depression of ventral horn neuronal responses (26% of control). Conclusions Propofol acts in the spinal cord to produce immobility. This depressive effect occurs in the ventral horn and is mediated mainly by GABAA receptors. Isoflurane also depresses neurons in the ventral horn; however, isoflurane actions at the GABAA receptor are either weak or overridden by other effects in the ventral horn. PMID:19372332

  9. National Offshore Wind Energy Grid Interconnection Study Full Report

    SciTech Connect

    Daniel, John P.; Liu, Shu; Ibanez, Eduardo; Pennock, Ken; Reed, Gregory; Hanes, Spencer

    2014-07-30

    The National Offshore Wind Energy Grid Interconnection Study (NOWEGIS) considers the availability and potential impacts of interconnecting large amounts of offshore wind energy into the transmission system of the lower 48 contiguous United States.

  10. Strengthening America's Energy Security with Offshore Wind (Fact Sheet)

    SciTech Connect

    Not Available

    2012-02-01

    This fact sheet describes the current state of the offshore wind industry in the United States and the offshore wind research and development activities conducted the U.S. Department of Energy Wind and Water Power Program.

  11. National Offshore Wind Energy Grid Interconnection Study Executive Summary

    SciTech Connect

    Daniel, John P.; Liu, Shu; Ibanez, Eduardo; Pennock, Ken; Reed, Gregory; Hanes, Spencer

    2014-07-30

    The National Offshore Wind Energy Grid Interconnection Study (NOWEGIS) considers the availability and potential impacts of interconnecting large amounts of offshore wind energy into the transmission system of the lower 48 contiguous United States.

  12. Offshore-platform decommissioning perceptions change

    SciTech Connect

    Twachtman, R.

    1997-12-08

    The oil and gas industry has seen a change in the perceptions about decommissioning offshore facilities. Now, decommissioning projects are being planned ahead of actual field development, and new concepts derived during decommissioning often are used to provide feedback for new development projects. The current trends and concepts applicable to decommissioning can be summarized as: advanced planning; engineered solutions; research and development; reuse; expanded use of offshore reefs; and deepwater disposal. Planning the platform decommissioning ahead of time (at least 2 years before production ceases) is key to a safe, environmentally conscious, and efficient decommissioning project. The paper discusses decommissioning projects, engineered solutions, research and development; reuse of platforms, and deepwater disposal.

  13. Regional method to assess offshore slope stability.

    USGS Publications Warehouse

    Lee, H.J.; Edwards, B.D.

    1986-01-01

    The slope stability of some offshore environments can be evaluated by using only conventional acoustic profiling and short-core sampling, followed by laboratory consolidation and strength testing. The test results are synthesized by using normalized-parameter techniques. The normalized data are then used to calculate the critical earthquake acceleration factors or the wave heights needed to initiate failure. These process-related parameters provide a quantitative measure of the relative stability for locations from which short cores were obtained. The method is most applicable to offshore environments of gentle relief and simple subsurface structure and is not considered a substitute for subsequent site-specific analysis. -from ASCE Publications Information

  14. Novel Function of Rev-erbα in Promoting Brown Adipogenesis

    PubMed Central

    Nam, Deokhwa; Chatterjee, Somik; Yin, Hongshan; Liu, Ruya; Lee, Jeongkyung; Yechoor, Vijay K.; Ma, Ke

    2015-01-01

    Brown adipose tissue is a major thermogenic organ that plays a key role in maintenance of body temperature and whole-body energy homeostasis. Rev-erbα, a ligand-dependent nuclear receptor and transcription repressor of the molecular clock, has been implicated in the regulation of adipogenesis. However, whether Rev-erbα participates in brown fat formation is not known. Here we show that Rev-erbα is a key regulator of brown adipose tissue development by promoting brown adipogenesis. Genetic ablation of Rev-erbα in mice severely impairs embryonic and neonatal brown fat formation accompanied by loss of brown identity. This defect is due to a cell-autonomous function of Rev-erbα in brown adipocyte lineage commitment and terminal differentiation, as demonstrated by genetic loss- and gain-of-function studies in mesenchymal precursors and brown preadipocytes. Moreover, pharmacological activation of Rev-erbα activity promotes, whereas its inhibition suppresses brown adipocyte differentiation. Mechanistic investigations reveal that Rev-erbα represses key components of the TGF-β cascade, an inhibitory pathway of brown fat development. Collectively, our findings delineate a novel role of Rev-erbα in driving brown adipocyte development, and provide experimental evidence that pharmacological interventions of Rev-erbα may offer new avenues for the treatment of obesity and related metabolic disorders. PMID:26058812

  15. Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction.

    PubMed

    Actis, Marcelo L; Ambaye, Nigus D; Evison, Benjamin J; Shao, Youming; Vanarotti, Murugendra; Inoue, Akira; McDonald, Ezelle T; Kikuchi, Sotaro; Heath, Richard; Hara, Kodai; Hashimoto, Hiroshi; Fujii, Naoaki

    2016-09-15

    DNA interstrand crosslink (ICL) repair (ICLR) has been implicated in the resistance of cancer cells to ICL-inducing chemotherapeutic agents. Despite the clinical significance of ICL-inducing chemotherapy, few studies have focused on developing small-molecule inhibitors for ICLR. The mammalian DNA polymerase ζ, which comprises the catalytic subunit REV3L and the non-catalytic subunit REV7, is essential for ICLR. To identify small-molecule compounds that are mechanistically capable of inhibiting ICLR by targeting REV7, high-throughput screening and structure-activity relationship (SAR) analysis were performed. Compound 1 was identified as an inhibitor of the interaction of REV7 with the REV7-binding sequence of REV3L. Compound 7 (an optimized analog of compound 1) bound directly to REV7 in nuclear magnetic resonance analyses, and inhibited the reactivation of a reporter plasmid containing an ICL in between the promoter and reporter regions. The normalized clonogenic survival of HeLa cells treated with cisplatin and compound 7 was lower than that for cells treated with cisplatin only. These findings indicate that a small-molecule inhibitor of the REV7/REV3L interaction can chemosensitize cells by inhibiting ICLR. PMID:27448776

  16. Relationship between Horn Pressure and Welding Time in Ultrasonic Welding of Plastic Pipes Using Torsional Vibration

    NASA Astrophysics Data System (ADS)

    Suga, Kenichi; Ohdaira, Etsuzo; Masuzawa, Nobuyoshi; Ide, Masao

    1999-05-01

    Application of ultrasonic welding to plastics has become common. Recently, an ultrasonic welding method for long plastic pipes using torsional vibrations was developed. Optimal welding conditions for this new method have not yet been clarified. This paper reports the results of an investigation made in order to clarify the conditions, focusing on the welding time and both horn pressure, static force that horns pinch pipe, and static pressure which is added to welding surface. Experiments were performed on the welding of acrylic resin and ABS resin pipes. It was found that welding time decreases exponentially with increasing horn pressure and that increasing the static pressure reduces the welding time. It was also found there is an optimum range ofhorn pressures.

  17. [Analysis and identification of water soluble components of water buffalo horn].

    PubMed

    Liu, Rui; Duan, Jin-ao; Wu, Hao; Liu, Pei; Shang, Er-xin; Qian, Da-wei

    2015-05-01

    This study is to analyze and identify the water soluble components of water buffalo horn (Bubali Cornu, WBH), and also establish a method for investigating these components. Shotgun proteomic analysis identified proteins in WBH aqueous extraction: keratin, collagen, desmoglein, etc. Ultrafiltration and LC-MS/MS were used to separate and identify the peptides in WBH aqueous extract, as a result, identified peptides were mainly derived from nonspecific degradation products of keratin and collagen, which including C-terminal peptides and non C-terminal peptides. Hypoxanthine, uridine, guanosine, and adenosine were identified by comparing with the standards. The strategy in present study could be used in analyzing water soluble components of animal horn derived TCM. It provides a reference for investigation of the material basis of animal horn derived TCM. PMID:26234143

  18. The Pterional-Transsylvian Approach for Tumor in the Temporal Horn: A Case Report

    PubMed Central

    Park, Jung-Hyun; Seung, Won-Bae; Lee, Sung Hun; Park, Yong-Seok

    2015-01-01

    A variety of surgical approaches to temporal horn tumors of the lateral ventricle have been described. Magnetic resonance imaging (MRI) and angiography are the preferred modalities for preoperative evaluation and provide important information for the choice of surgical approach. A 59-year-old man was referred to our hospital due to confusion and gait disturbance. On enhanced MRI, a homogeneous enhanced solitary mass was observed within the temporal horn of the left lateral ventricle with transependymal extension. The lesion was accompanied by increased hypervascular tumor blush on preoperative cerebral angiography. Subtotal removal of the temporal horn tumor was performed because the lesion was identified as lymphoma during surgery. The postoperative course was un-eventful. The patient was referred to the oncology department for conventional chemotherapy. Adjuvant chemotherapy improved the clinical outcome. The pterional-transsylvian approach was beneficial for partial removal of the tumor and tissue diagnosis in this case. PMID:26605268

  19. The chemical oceanographic consequences of environmental restoration projects in the Golden Horn estuary (Marmara Sea, Turkey).

    PubMed

    Balkis, N; Müftüoğlu, E; Aksu, A; Sur, H I; Apak, R

    2010-05-01

    The input of industrial and domestic waste to the horizontal circulation in the Golden Horn Estuary of Marmara Sea has resulted in one of the most polluted estuaries in the past. Consequently, the dissolved oxygen concentrations in both the surface and bottom waters decreased toward to the estuary head during 1998-2005. In contrast, the total suspended solids content of the surface water decreased toward to the estuary mouth. However, construction of the operational collector system surrounding the estuary during the process of rehabilitation projects, combined with the opening of the middle pontoons of the Valide Sultan Bridge, resulted in gradually improved water quality of the estuary with a concomitant decrease in pollution. However, phytoplankton blooms and eutrophication persist especially in the innermost part of the Golden Horn in 2005. The region from the estuary mouth up to Camialti has a dynamic structure, and sufficient circulation seemingly occurs in this part of the Golden Horn. PMID:19353286

  20. Spontaneous second-trimester ruptured pregnancy of rudimentary horn: a case report in Yaounde, Cameroon

    PubMed Central

    Fouelifack, Florent Ymele; Fouogue, Jovanny Tsuala; Messi, John Owoudou; Kamga, Danielle Tiako; Fouedjio, Jeanne Hortence; Sando, Zacharie

    2014-01-01

    Rudimentary uterine horn pregnancy is rare and, to our knowledge, has not been previously reported in Cameroon. We herein report the case of a 22 year old second gravida referred for acute abdominal pain at 17 weeks of gestation. Physical examination revealed hemoperitoneum with hypovolemic shock. After resuscitation, an emergency exploratory laparotomy was done and we found hemoperitoneum of 3,500 milliliters, a bicornuate uterus with a ruptured right rudimentary communicating horn containing a non viable foetus. There were no other abnormalities. We performed an excision of the rudimentary horn with ipsilateral salpingectomy. Post-operative course was uneventful and the woman was discharged seven days later. This case emphasizes the importance of good antenatal care to avoid complications. PMID:25400853

  1. Susceptibility to diazinon in populations of the horn fly, Haematobia irritans (Diptera: Muscidae), in Central Brazil.

    PubMed

    Barros, Antonio Thadeu M; Gomes, Alberto; Ismael, Ana Paula K; Koller, Wilson W

    2002-09-01

    From October 2000 to April 2001, insecticide bioassays were conducted in 18 ranches from 10 counties in the states of Mato Grosso and Mato Grosso do Sul, in Central Brazil. Horn flies from wild populations were exposed to diazinon-impregnated filter papers immediately after collection on cattle, and mortality was recorded after 2 h. A high susceptibility to diazinon was observed in all tested populations. The LC50s ranged from 0.15 to 0.64 micro g/cm2, and resistance ratios were always lower than one (ranging 0.1-0.6). Pyrethroid products, most applied by backpack sprayers, have been used since the horn fly entered the region, about 10 years ago. The high susceptibility observed to diazinon indicates that this insecticide (as probably other organophosphate insecticides) represents an useful tool for horn fly control and resistance management, particularly in pyrethroid-resistant populations. PMID:12386720

  2. Control of horn fly (Diptera: Muscidae) in Florida with an Australian trap.

    PubMed

    Tozer, R S; Sutherst, R W

    1996-04-01

    A newly developed Haematobia spp. trap is described, and results are presented from field trials to reduce populations of adult horn fly, Haematobia irritans L., on 5 dairy farms in western Florida and Alabama during the summer of 1992. We compared fly infestations on milkers subjected to trapping, versus either dry cattle on the same farm or milkers on a nearby farm, without the trap but where traditional horn fly control practices were used. Results gave 96.9% (95% CI, 93.8-98.4) reduction compared with dry cattle with a mean count of 228 per animal, and 90.2% (84.5-94.5%) compared with milkers on the control farms with a mean count of 113. Trapping removed the need to use insecticides to control this pest on milking dairy cattle and so offers a practical, environmentally acceptable, safe, and sustainable means of horn fly control on cattle which pass through the trap regularly. PMID:8934825

  3. Horn-coupled, commercially-fabricated aluminum lumped-element kinetic inductance detectors for millimeter wavelengths.

    PubMed

    McCarrick, H; Flanigan, D; Jones, G; Johnson, B R; Ade, P; Araujo, D; Bradford, K; Cantor, R; Che, G; Day, P; Doyle, S; Leduc, H; Limon, M; Luu, V; Mauskopf, P; Miller, A; Mroczkowski, T; Tucker, C; Zmuidzinas, J

    2014-12-01

    We discuss the design, fabrication, and testing of prototype horn-coupled, lumped-element kinetic inductance detectors (LEKIDs) designed for cosmic microwave background studies. The LEKIDs are made from a thin aluminum film deposited on a silicon wafer and patterned using standard photolithographic techniques at STAR Cryoelectronics, a commercial device foundry. We fabricated 20-element arrays, optimized for a spectral band centered on 150 GHz, to test the sensitivity and yield of the devices as well as the multiplexing scheme. We characterized the detectors in two configurations. First, the detectors were tested in a dark environment with the horn apertures covered, and second, the horn apertures were pointed towards a beam-filling cryogenic blackbody load. These tests show that the multiplexing scheme is robust and scalable, the yield across multiple LEKID arrays is 91%, and the measured noise-equivalent temperatures for a 4 K optical load are in the range 26±6 μK√s. PMID:25554282

  4. Horn-coupled, commercially-fabricated aluminum lumped-element kinetic inductance detectors for millimeter wavelengths

    SciTech Connect

    McCarrick, H. Flanigan, D.; Jones, G.; Johnson, B. R.; Araujo, D.; Limon, M.; Luu, V.; Miller, A.; Ade, P.; Doyle, S.; Tucker, C.; Bradford, K.; Che, G.; Cantor, R.; Day, P.; Leduc, H.; Mauskopf, P.; Mroczkowski, T.; Zmuidzinas, J.

    2014-12-15

    We discuss the design, fabrication, and testing of prototype horn-coupled, lumped-element kinetic inductance detectors (LEKIDs) designed for cosmic microwave background studies. The LEKIDs are made from a thin aluminum film deposited on a silicon wafer and patterned using standard photolithographic techniques at STAR Cryoelectronics, a commercial device foundry. We fabricated 20-element arrays, optimized for a spectral band centered on 150 GHz, to test the sensitivity and yield of the devices as well as the multiplexing scheme. We characterized the detectors in two configurations. First, the detectors were tested in a dark environment with the horn apertures covered, and second, the horn apertures were pointed towards a beam-filling cryogenic blackbody load. These tests show that the multiplexing scheme is robust and scalable, the yield across multiple LEKID arrays is 91%, and the measured noise-equivalent temperatures for a 4 K optical load are in the range 26±6 μK√(s)

  5. The C-, G-, and R-banded karyotype of the scimitar-horned oryx (Oryx dammah).

    PubMed

    Claro, F; Hayes, H; Cribiu, E P

    1994-01-01

    Karyotypes of five males and one female scimitar-horned oryx (Oryx dammah) were prepared using lymphocyte and skin cells. CBG-, GTG-, and RBG-banded chromosomes were analysed and the banding patterns were compared with those of cattle, revealing a high level of homoeology except for chromosomes 9, 14, 21, Y, and X. Standard karyotypes are proposed for the scimitar-horned oryx karyotype, which contains 58 chromosomes with one pair of large submetacentric autosomes and 27 acrocentric autosomal pairs. The X and Y chromosomes are the largest and smallest acrocentrics. The scimitar-horned oryx chromosome 1 is submetacentric and appears to result from the fusion between ancestral forms of bovid chromosomes numbered 1 and 29 according to the READING CONFERENCE (1980) nomenclature and to ISCNDA 89 if GTG-banding is used. PMID:8206781

  6. Spontaneous second-trimester ruptured pregnancy of rudimentary horn: a case report in Yaounde, Cameroon.

    PubMed

    Fouelifack, Florent Ymele; Fouogue, Jovanny Tsuala; Messi, John Owoudou; Kamga, Danielle Tiako; Fouedjio, Jeanne Hortence; Sando, Zacharie

    2014-01-01

    Rudimentary uterine horn pregnancy is rare and, to our knowledge, has not been previously reported in Cameroon. We herein report the case of a 22 year old second gravida referred for acute abdominal pain at 17 weeks of gestation. Physical examination revealed hemoperitoneum with hypovolemic shock. After resuscitation, an emergency exploratory laparotomy was done and we found hemoperitoneum of 3,500 milliliters, a bicornuate uterus with a ruptured right rudimentary communicating horn containing a non viable foetus. There were no other abnormalities. We performed an excision of the rudimentary horn with ipsilateral salpingectomy. Post-operative course was uneventful and the woman was discharged seven days later. This case emphasizes the importance of good antenatal care to avoid complications. PMID:25400853

  7. Unilateral intrauterine horn insemination of fresh semen in cats.

    PubMed

    Tsutsui, T; Tanaka, A; Takagi, Y; Nakagawa, K; Fujimoto, Y; Murai, M; Anzai, M; Hori, T

    2000-12-01

    The sperm count required were investigated to obtain a conception rate of 80% by unilateral intrauterine insemination (UIUI) of fresh semen in cats. The conception rates obtained by insemination before and after ovulation were also examined. Thirty-six female cats aged 1-7 years were used in the experiments, and the number of experimental cases was 44. Seven male cats aged 2-12 years from which semen could be collected by the artificial vagina method were used. In artificial insemination, 100 iu x 2 or 250 iu of hCG was administered on days 2-4 of estrus, and sperm were introduced into the uterine horn with a greater number of ovulations (or mature follicles) 15, 20 and 30 hr after hCG administration by laparotomy. The inseminated sperm counts were 2 x 10(6) (Exp. 1). 4 x 10(6) (Exp. 2), and 8 x 10(6) (Exp. 3). As a result, ovulation was induced in 42 of 44 cases (induction rate: 95.5%) regardless of the dosage of hCG. Conception was obtained by UIUI in two of 16 animals (conception rate: 12.5%) in the Exp. 1, five of 16 animals (31.3%) in Exp. 2, and eight of 10 animals (80.0%) in Exp. 3. Regarding the relationship between the ovulation state at insemination and conception, the conception rate obtained by insemination before ovulation was clearly higher than that obtained by insemination after ovulation (p<0.05). Regarding the number of kits compared to the number of ovulations on the inseminated side, the percentages of cases in which the number of kits exceeded the number of ovulations on the inseminated side were similar in all groups inseminated with a different number of sperm. It is therefore necessary to investigate conception rates obtained by bilateral insemination to increase the fertility rate. Based on the above findings, it was shown that the sperm count required for fertilization by UIUI is 8 x 10(6). PMID:11193338

  8. Boundary Spanning in Offshored Information Systems Development Projects

    ERIC Educational Resources Information Center

    Krishnan, Poornima

    2010-01-01

    Recent growth in offshore outsourcing of information systems (IS) services is accompanied by managing the offshore projects successfully. Much of the project failures can be attributed to geographic and organizational boundaries which create differences in culture, language, work patterns, and decision making processes among the offshore project…

  9. 47 CFR 22.1007 - Channels for offshore radiotelephone systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Channels for offshore radiotelephone systems. 22.1007 Section 22.1007 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Offshore Radiotelephone Service § 22.1007 Channels for offshore radiotelephone systems. The channels listed in...

  10. 76 FR 24504 - National Offshore Safety Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-02

    ... SECURITY National Offshore Safety Advisory Committee AGENCY: United States Coast Guard, DHS. ACTION: Committee Management; Notice of Federal Advisory Committee Meeting. SUMMARY: The National Offshore Safety... Federal Advisory Committee Act, 5 U.S.C. App. (Pub. L. 92-463). The National Offshore Safety...

  11. 78 FR 18618 - National Offshore Safety Advisory Committee; Vacancies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-27

    ... SECURITY Coast Guard National Offshore Safety Advisory Committee; Vacancies AGENCY: United States Coast... Offshore Safety Advisory Committee (NOSAC). NOSAC advises the Secretary of the Department of Homeland... exploration of offshore mineral and energy resources insofar as they relate to matters within Coast...

  12. International Offshore Students' Perceptions of Virtual Office Hours

    ERIC Educational Resources Information Center

    Wdowik, Steven; Michael, Kathy

    2013-01-01

    Purpose: The main aim of this study is to gauge international offshore students' perceptions of virtual office hours (VOH) to consult with their offshore unit coordinators in Australia. Design/methodology/approach: This paper employs a quantitative and qualitative approach where data was sourced from three offshore campuses over a 12-month period…

  13. Glial glutamate transporter and glutamine synthetase regulate GABAergic synaptic strength in the spinal dorsal horn.

    PubMed

    Jiang, Enshe; Yan, Xisheng; Weng, Han-Rong

    2012-05-01

    Decreased GABAergic synaptic strength ('disinhibition') in the spinal dorsal horn is a crucial mechanism contributing to the development and maintenance of pathological pain. However, mechanisms leading to disinhibition in the spinal dorsal horn remain elusive. We investigated the role of glial glutamate transporters (GLT-1 and GLAST) and glutamine synthetase in maintaining GABAergic synaptic activity in the spinal dorsal horn. Electrically evoked GABAergic inhibitory post-synaptic currents (eIPSCs), spontaneous IPSCs (sIPSCs) and miniature IPSCs were recorded in superficial spinal dorsal horn neurons of spinal slices from young adult rats. We used (2S,3S)-3-[3-[4-(trifluoromethyl)benzoylamino]benzyloxy]aspartate (TFB-TBOA), to block both GLT-1 and GLAST and dihydrokainic acid to block only GLT-1. We found that blockade of both GLAST and GLT-1 and blockade of only GLT-1 in the spinal dorsal horn decreased the amplitude of GABAergic eIPSCs, as well as both the amplitude and frequency of GABAergic sIPSCs or miniature IPSCs. Pharmacological inhibition of glial glutamine synthetase had similar effects on both GABAergic eIPSCs and sIPSCs. We provided evidence demonstrating that the reduction in GABAergic strength induced by the inhibition of glial glutamate transporters is due to insufficient GABA synthesis through the glutamate-glutamine cycle between astrocytes and neurons. Thus, our results indicate that deficient glial glutamate transporters and glutamine synthetase significantly attenuate GABAergic synaptic strength in the spinal dorsal horn, which may be a crucial synaptic mechanism underlying glial-neuronal interactions caused by dysfunctional astrocytes in pathological pain conditions. PMID:22339645

  14. Changes in biodiversity of the extremely polluted Golden Horn Estuary following the improvements in water quality.

    PubMed

    Yüksek, Ahsen; Okuş, Erdoğan; Yilmaz, I Noyan; Aslan-Yilmaz, Asli; Taş, Seyfettin

    2006-10-01

    Long-term biological data supported by physicochemical parameters were evaluated to investigate the biodiversity of the Golden Horn Estuary from the past to the present. Limited observations dating back to 60 years ago indicated the existence of a diverse community in this small estuary. Unfortunately, in parallel with the increase in unplanned settlements and industry around the Golden Horn, pollution stress increased since the 1960s. Preliminary studies in the 1990s indicated survival of only a couple of pollution-resistant species, in the relatively cleaner lower estuary. Following the intensification of rehabilitation studies in 1998 and particularly after the opening of the floating bridge at the mid estuary; a remarkable day-by-day recovery in marine life has begun with the improving water quality. Nutrient concentrations decreased markedly; while water clarity significantly increased. Fecal coliform values decreased 10(3) fold. Phytoplankton composition changed and dense blooms of eukaryotic phytoplankters frequently occurred. Hydrogen sulfide almost completely disappeared even during the warmest periods of the year and dissolved oxygen concentrations increased. All results clearly depicted that the Golden Horn ecosystem shifted to eutrophic conditions from an anoxic environment. SCUBA dives in 2002, documented the level of diversification of life in the Golden Horn. All appropriate substratums were intensely covered by macrobenthic forms until the Halic Bridge and filter feeders dominated the plankton-rich ecosystem. Achieving the diversity of 1940s is not possible since the Black and Marmara seas, influencing water quality of the Golden Horn, are also suffering from anthropogenic impacts and are far less diverse than their rich diversity in 1940s. However, the Golden Horn is a good example that even the most polluted ecosystems can recover when appropriate measures are taken. PMID:16814327

  15. Reducing physical size limits for low-frequency horn loudspeaker systems

    NASA Astrophysics Data System (ADS)

    Honeycutt, Richard Allison

    From 1881 until the present day, many excellent scholars have studied acoustic horns. This dissertation begins by discussing over eighty results of such study. Next, the methods of modeling horn behavior are examined with an emphasis on the prediction of throat impedance. Because of the time constraints in a product-design environment, in which the results of this study may be used, boundary-element and cascaded-section types of analysis were not considered due to their time intensiveness. Of the methods studied, an analytical process based upon Olson's adaptation of Webster's analysis is selected as the most accurate of the rapid methods, although other good methods exist. Reasons and extent of inaccuracy are discussed. The concept of interleaved horn loading is introduced: it involves using two horns of different parameters, fed by a single driver, with a view toward interleaving and thus smoothing the impedance peaks of the separate horns to produce a smoother response. The validity of the technique is demonstrated both theoretically and practically. Then the reactance annulling technique is explained and tested experimentally. It is found to work well, but the exact parameter values involved are not found to be critical. Finally, the considerations involved in building a practical working system are discussed, and a preliminary working model reviewed. Future work could be directed toward finding the optimum parameter values for the two "parallel horns" whose impedances are to be interleaved, as well as the system parameters that determine these optimum values. Also, further experimental investigation or ported loading of the back air chamber would be useful.

  16. Predicted Loading on the Menisci during Gait: The Effect of Horn Laxity

    PubMed Central

    Guess, Trent M.; Razu, Swithin; Jahandar, Hamidreza; Stylianou, Antonis

    2015-01-01

    Radiographic measurements have established a link between meniscus extrusion and meniscus degeneration as well as with knee osteoarthritis. The presented work combines medical imaging with motion capture data from two healthy female subjects to create subject specific knee models that predict tibio-menisco-femoral contact forces and ligament forces during muscle driven simulations of barefoot gait. The developed computational models were used to explore the relationship between the extent of meniscal extrusion and biomechanical function by altering the laxity of the meniscal horn attachments during gait. The extrusion distance increased as laxity increased and the amount of contact force transferred through the menisci during gait decreased rapidly as the meniscal attachments became more lax. Horn attachment lengths that were 20% longer than MRI attachment lengths resulted in an almost complete loss of force transfer through the menisci during the gait cycle. Relatively small changes (2 to 3 mm) in the lengths at which horn bundles first become taut, manifested in large changes in the capacity of the tissue to transmit forces. As meniscal horn attachment laxity increased from 80% to 120% of the MRI measured horn distance, medial meniscus extrusion increased 3.9 mm for the first subject and 2.7 mm for the second subject. For the same horn laxity changes, the percent of medial tibiofemoral contact force transmitted through the medial meniscus during early stance decreased from 51% to 8% and from 36% to 14% for the two subjects. The results of our study show that increased meniscal extrusion occurs with increased laxity of the meniscal tibia attachments and this increased laxity results in loss of meniscal function. PMID:25814179

  17. United States Offshore Wind Resource Assessment

    NASA Astrophysics Data System (ADS)

    Schwartz, M.; Haymes, S.; Heimiller, D.

    2008-12-01

    The utilization of the offshore wind resource will be necessary if the United States is to meet the goal of having 20% of its electricity generated by wind power because many of the electrical load centers in the country are located along the coastlines. The United States Department of Energy, through its National Renewable Energy Laboratory (NREL), has supported an ongoing project to assess the wind resource for the offshore regions of the contiguous United States including the Great Lakes. Final offshore maps with a horizontal resolution of 200 meters (m) have been completed for Texas, Louisiana, Georgia, northern New England, and the Great Lakes. The ocean wind resource maps extend from the coastline to 50 nautical miles (nm) offshore. The Great Lake maps show the resource for all of the individual lakes. These maps depict the wind resource at 50 m above the water as classes of wind power density. Class 1 represents the lowest available wind resource, while Class 7 is the highest resource. Areas with Class 5 and higher wind resource can be economical for offshore project development. As offshore wind turbine technology improves, areas with Class 4 and higher resource should become economically viable. The wind resource maps are generated using output from a modified numerical weather prediction model combined with a wind flow model. The preliminary modeling is performed by AWS Truewind under subcontract to NREL. The preliminary model estimates are sent to NREL to be validated. NREL validates the preliminary estimates by comparing 50 m model data to available measurements that are extrapolated to 50 m. The validation results are used to modify the preliminary map and produce the final resource map. The sources of offshore wind measurement data include buoys, automated stations, lighthouses, and satellite- derived ocean wind speed data. The wind electric potential is represented as Megawatts (MW) of potential installed capacity and is based on the square

  18. Salivary gland thrombostasin isoforms differentilally regulate blood uptake of horn flies fed on New Zealand white rabbits

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Thrombostasin (TS) is a previously characterized anticlotting protein with multiple isoforms found in the saliva of horn flies. In this report the effects of TS isoforms on blood feeding was assessed with individual flies that carried corresponding ts alleles. Laboratory studies of horn fly blood fe...

  19. 75 FR 18201 - Big Horn II Wind Project, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Big Horn II Wind Project, LLC; Supplemental Notice That Initial Market-Based... supplemental notice in the above-referenced proceeding of Big Horn II Wind Project, LLC's application...

  20. 50 CFR 21.44 - Depredation order for horned larks, house finches, and white-crowned sparrows in California.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... BIRD PERMITS Control of Depredating and Otherwise Injurious Birds § 21.44 Depredation order for horned... horticultural crops. Take of birds under this order must be done under the supervision of the county agriculture... bird species, or for take of horned larks or white-crowned sparrows from May 1 through October 31....

  1. 75 FR 9377 - Endangered and Threatened Wildlife and Plants; Listing the Flat-Tailed Horned Lizard as Threatened

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... distinct vertebrate population segments (61 FR 4722). (6) The potential effects global climate change may..., 1993 (58 FR 62624), to list the flat-tailed horned lizard as a threatened species, and reopens the... proposed rule to list the flat-tailed horned lizard as a threatened species under the Act (58 FR 62624)....

  2. Use of electroporation as an option to transform the Horn Fly, Haematobia irritans: a species recalcitrant to microinjection

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Horn flies are serious pests of cattle in North America and control of these flies has primarily relied on insecticides. However, the heavy use of insecticides has led to the development of resistance in horn flies and novel methods of fly control are greatly needed. The use of transformation techno...

  3. Comparisons of antifeedancy and spatial repellency of three natural product repellents against horn flies, Haematobia irritans (Diptera: Muscidae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    BACKGROUND: Horn flies are among the most important biting fly pests of cattle in the United States. Horn fly management is largely dependent upon pesticides, which ultimately leads to the rapid development of insecticide resistance. Alternative control strategies, including repellents, have shown p...

  4. Salivary Gland Thrombostasin Isoforms Differentially Regulate Blood Uptake of Horn Flies Fed on New Zealand White Rabbits

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Thrombostasin (TS) is a previously characterized anticlotting protein with multiple isoforms found in the saliva of horn flies. In this report the effects of TS isoforms on blood feeding was assessed with individual flies that carried corresponding ts alleles. Laboratory studies of horn fly blood fe...

  5. Salivary Gland Thrombostasin Isoforms Differentially Regulate Blood Uptake of Horn Flies Fed on Control- and Thrombostasin-Vaccinated Cattle

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Thrombostasin (TS) is an anticlotting protein found in saliva of Haematobia irritans (horn flies). The polymorphic nature of the ts gene was first associated with success of horn flies blood feeding on a laboratory host, New Zealand White rabbits. In this study, we report results of similar studies ...

  6. Cloning and characterization of an MRNA encoding an insulin receptor from the horned scarab beetle Onthophagus nigriventris (Coleoptera: scarabaeidae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The insulin signaling pathway has been implicated in the control of insect polyphenisms for some caste-forming insects and potentially has a role in horn dimorphisms in beetles. Males of the sexually dimorphic dung beetle Onthophagus nigriventris develop a magnificent thoracic horn up to twice the l...

  7. Lake Michigan Offshore Wind Feasibility Assessment

    SciTech Connect

    Boezaart, Arnold; Edmonson, James; Standridge, Charles; Pervez, Nahid; Desai, Neel; Williams, Bruce; Clark, Aaron; Zeitler, David; Kendall, Scott; Biddanda, Bopi; Steinman, Alan; Klatt, Brian; Gehring, J. L.; Walter, K.; Nordman, Erik E.

    2014-06-30

    The purpose of this project was to conduct the first comprehensive offshore wind assessment over Lake Michigan and to advance the body of knowledge needed to support future commercial wind energy development on the Great Lakes. The project involved evaluation and selection of emerging wind measurement technology and the permitting, installation and operation of the first mid-lake wind assessment meteorological (MET) facilities in Michigan’s Great Lakes. In addition, the project provided the first opportunity to deploy and field test floating LIDAR and Laser Wind Sensor (LWS) technology, and important research related equipment key to the sitting and permitting of future offshore wind energy development in accordance with public participation guidelines established by the Michigan Great Lakes Wind Council (GLOW). The project created opportunities for public dialogue and community education about offshore wind resource management and continued the dialogue to foster Great Lake wind resource utilization consistent with the focus of the GLOW Council. The technology proved to be effective, affordable, mobile, and the methods of data measurement accurate. The public benefited from a substantial increase in knowledge of the wind resources over Lake Michigan and gained insights about the potential environmental impacts of offshore wind turbine placements in the future. The unique first ever hub height wind resource assessment using LWS technology over water and development of related research data along with the permitting, sitting, and deployment of the WindSentinel MET buoy has captured public attention and has helped to increase awareness of the potential of future offshore wind energy development on the Great Lakes. Specifically, this project supported the acquisition and operation of a WindSentinel (WS) MET wind assessment buoy, and associated research for 549 days over multiple years at three locations on Lake Michigan. Four research objectives were defined for the

  8. Study of Saiga Horn Using High-Performance Liquid Chromatography with Mass Spectrometry

    PubMed Central

    Mikulíková, Kateřina; Romanov, Oleg; Miksik, Ivan; Eckhardt, Adam; Pataridis, Statis; Sedláková, Pavla

    2012-01-01

    The saiga horns have been investigated the using of modern analytic methods. High-performance liquid chromatography (HPLC) with mass-spectrometric (MS and MS/MS) detection and polyacrylamide gel electrophoresis (PAGE) were used. It could be concluded that basic proteins of the saiga horns are keratins and collagen. The basic representation protein in all samples is keratin type I microfibrillar (from sheep), keratin type II microfibrillar (from sheep), collagen type I (α1) (from bovine) and collagen type I (α2) (from bovine). Free amino acids we determined in all samples are nontreated by enzyme. PMID:22629195

  9. Chained Clauser-Horne-Shimony-Holt inequality for Hardy's ladder test of nonlocality

    NASA Astrophysics Data System (ADS)

    Cereceda, José Luis

    2016-04-01

    Relativistic causality forbids superluminal signaling between distant observers. By exploiting the non-signaling principle, we derive the exact relationship between the chained Clauser-Horne-Shimony-Holt sum of correlations {CHSH}_K and the success probability P_K associated with Hardy's ladder test of nonlocality for two qubits and K+1 observables per qubit. Then, by invoking the Tsirelson bound for {CHSH}_K, the derived relationship allows us to establish an upper limit on P_K. In addition, we draw the connection between {CHSH}_K and the chained version of the Clauser-Horne (CH) inequality.

  10. Abrupt shifts in Horn of Africa hydroclimate since the Last Glacial Maximum.

    PubMed

    Tierney, Jessica E; deMenocal, Peter B

    2013-11-15

    The timing and abruptness of the initiation and termination of the Early Holocene African Humid Period are subjects of ongoing debate, with direct consequences for our understanding of abrupt climate change, paleoenvironments, and early human cultural development. Here, we provide proxy evidence from the Horn of Africa region that documents abrupt transitions into and out of the African Humid Period in northeast Africa. Similar and generally synchronous abrupt transitions at other East African sites suggest that rapid shifts in hydroclimate are a regionally coherent feature. Our analysis suggests that the termination of the African Humid Period in the Horn of Africa occurred within centuries, underscoring the nonlinearity of the region's hydroclimate. PMID:24114782

  11. Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn

    PubMed Central

    Punnakkal, Pradeep; Schoultz, Carolin; Haenraets, Karen; Wildner, Hendrik; Zeilhofer, Hanns Ulrich

    2014-01-01

    Interneurons of the spinal dorsal horn are central to somatosensory and nociceptive processing. A mechanistic understanding of their function depends on profound knowledge of their intrinsic properties and their integration into dorsal horn circuits. Here, we have used BAC transgenic mice expressing enhanced green fluorescent protein (eGFP) under the control of the vesicular glutamate transporter (vGluT2) gene (vGluT2::eGFP mice) to perform a detailed electrophysiological and morphological characterisation of excitatory dorsal horn neurons, and to compare their properties to those of GABAergic (Gad67::eGFP tagged) and glycinergic (GlyT2::eGFP tagged) neurons. vGluT2::eGFP was detected in about one-third of all excitatory dorsal horn neurons and, as demonstrated by the co-expression of vGluT2::eGFP with different markers of subtypes of glutamatergic neurons, probably labelled a representative fraction of these neurons. Three types of dendritic tree morphologies (vertical, central, and radial), but no islet cell-type morphology, were identified in vGluT2::eGFP neurons. vGluT2::eGFP neurons had more depolarised action potential thresholds and longer action potential durations than inhibitory neurons, while no significant differences were found for the resting membrane potential, input resistance, cell capacitance and after-hyperpolarisation. Delayed firing and single action potential firing were the single most prevalent firing patterns in vGluT2::eGFP neurons of the superficial and deep dorsal horn, respectively. By contrast, tonic firing prevailed in inhibitory interneurons of the dorsal horn. Capsaicin-induced synaptic inputs were detected in about half of the excitatory and inhibitory neurons, and occurred more frequently in superficial than in deep dorsal horn neurons. Primary afferent-evoked (polysynaptic) inhibitory inputs were found in the majority of glutamatergic and glycinergic neurons, but only in less than half of the GABAergic population. Excitatory

  12. Diagnosis and management of a ruptured rudimentary horn pregnancy in a low-resource setting.

    PubMed

    Nathan, Hannah; Sornum, Alvin

    2013-01-01

    A 22-year-old woman presented with amenorrhoea, lower abdominal pain and brown vaginal discharge. She was noted to be in hypovolaemic shock with a distended and peritonitic abdomen. On bimanual examination, the uterus was not palpated, the posterior fornix was full and cervical excitation was present. A clinical diagnosis of a ruptured ectopic pregnancy was made. She was resuscitated and an emergency laparotomy was performed. Intraoperatively, a ruptured rudimentary horn with an ex utero pregnancy was discovered. The right horn and tube were removed, as was the non-viable fetus. There were no postoperative complications and the patient was discharged after 5 days of observation. PMID:23749832

  13. Diagnosis and management of a ruptured rudimentary horn pregnancy in a low-resource setting

    PubMed Central

    Nathan, Hannah; Sornum, Alvin

    2013-01-01

    A 22-year-old woman presented with amenorrhoea, lower abdominal pain and brown vaginal discharge. She was noted to be in hypovolaemic shock with a distended and peritonitic abdomen. On bimanual examination, the uterus was not palpated, the posterior fornix was full and cervical excitation was present. A clinical diagnosis of a ruptured ectopic pregnancy was made. She was resuscitated and an emergency laparotomy was performed. Intraoperatively, a ruptured rudimentary horn with an ex utero pregnancy was discovered. The right horn and tube were removed, as was the non-viable fetus. There were no postoperative complications and the patient was discharged after 5 days of observation. PMID:23749832

  14. The hydrodynamics of the Big Horn Basin: a study of the role of faults

    USGS Publications Warehouse

    Bredehoeft, J.D.; Belitz, K.; Sharp-Hansen, S.

    1992-01-01

    A three-dimensional mathematical model simulates groundwater flow in the Big Horn basin, Wyoming. The hydraulic head at depth over much of the Big Horn basin is near the land surface elevation, a condition usually defined as hydrostatic. This condition indicates a high, regional-scale, vertical conductivity for the sediments in the basin. Our hypothesis to explain the high conductivity is that the faults act as vertical conduits for fluid flow. These same faults can act as either horizontal barriers to flow or nonbarriers, depending upon whether the fault zones are more permeable or less permeable than the adjoining aquifers. -from Authors

  15. Neogene and Quaternary geology of a stratigraphic test hole on Horn Island, Mississippi Sound

    USGS Publications Warehouse

    Gohn, Gregory S.; Brewster-Wingard, G. Lynn; Cronin, Thomas M.; Edwards, Lucy E.; Gibson, Thomas G.; Rubin, Meyer; Willard, Debra A.

    1996-01-01

    During April and May, 1991, the U.S. Geological Survey (USGS) drilled a 510-ft-deep, continuously cored, stratigraphic test hole on Horn Island, Mississippi Sound, as part of a field study of the Neogene and Quaternary geology of the Mississippi coastal area. The USGS drilled two new holes at the Horn Island site. The first hole was continuously cored to a depth of 510 ft; coring stopped at this depth due to mechanical problems. To facilitate geophysical logging, an unsampled second hole was drilled to a depth of 519 ft at the same location.

  16. Taxonomic and nomenclatorial revision within the Neotropical genera of the subtribe Odontocheilina W. Horn in a new sense-15. The genus Opisthencentrus W. Horn (Coleoptera: Cicindelidae).

    PubMed

    Moravec, Jiří

    2016-01-01

    The Neotropical, monobasic tiger beetle genus Opisthencentrus W. Horn, 1893, based on Oxygonia dentipennis Germar, 1843, is presented along with a lectotype designation. Most of the diagnostic characters of Opisthencentrus dentipennis (Germar, 1843), including the aedeagus and structures of the internal sac, are illustrated for the first time. Redescription and illustrations in colour photographs of the habitus and diagnostic characters of the female lectotype (MFNB) and five other specimens of both sexes are provided. The validity of Opisthencentrus as a separate genus is confirmed and it is concluded that the genus is a natural member of the subtribe Odontocheilina W. Horn, 1899, markedly differing from the genus Oxygonia Mannerheim, 1837. The history of the taxonomy and relationship to other genera of the subtribe, as well as the biology and distribution of this very rare and hitherto little known tiger beetle in the Brazilian Atlantic rain-forest, are discussed. PMID:27394549

  17. Wind-Tunnel Investigation of Shielded Horn Balances and Tabs on a 0.7-Scale Model of XF6F Vertical Tail Surface

    NASA Technical Reports Server (NTRS)

    Lowry, John G.; Maloney, James A.; Garner, I Elizabeth

    1944-01-01

    Results of subject tests indicate the difficulty of obtaining closely balanced rudder surfaces for most tail assemblies with shielded horns and maintaining a near zero rate-of-change of hinge-moment coefficient without an additional balancing device. A comparison is made between shielded and unshielded horn test results. Pressure distribution and tuft tests of flow over different shaped horns showed higher critical speed for medium-taper nosed horn. The trim tab nose shape had little effect on tab test results.

  18. Quantitative differences in the histology of the attachment zones of the meniscal horns in the knee joint of man.

    PubMed Central

    Benjamin, M; Evans, E J; Rao, R D; Findlay, J A; Pemberton, D J

    1991-01-01

    The attachment zones of the meniscal horns of 7 dissecting room cadavers were examined by routine histology. All the knees were devoid of gross pathological change and no discoid menisci were included. Significant differences are reported in the thickness of the zones of uncalcified fibrocartilage and cortical calcified tissue (calcified fibrocartilage and underlying lamellar bone) and in the percentage of bone:bone marrow. There was a thicker zone of uncalcified fibrocartilage and a greater quantity of calcified tissue at the horns of the lateral than the medial meniscus. The differences in uncalcified fibrocartilage were largely attributable to the posterior horns, but the variations in calcified tissue mainly reflected differences between the anterior horns. It is suggested that the greater mobility of the lateral meniscus and the blending of its anterior horn with the anterior cruciate ligament are important factors accounting for the quantitative differences in the meniscal attachment zones. Images Fig. 2 Fig. 3 PMID:1769887

  19. Cut drydocking costs for offshore rigs

    SciTech Connect

    Albaugh, E.K.

    1985-07-01

    Heavy-lift transport vessels (HLVs) can provide an economic alternative to the conventional shipyard approach of drydocking mobile offshore rigs for regulatory body inspections and/or repairs. Contractors now can drydock rigs in areas of the world where conventional drydocks are unavailable. This article discusses pros and cons of conventional shipyard drydocking and the HLV approach.

  20. 31 CFR 544.406 - Offshore transactions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Offshore transactions. 544.406 Section 544.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION PROLIFERATORS...

  1. 31 CFR 544.406 - Offshore transactions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Offshore transactions. 544.406 Section 544.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION PROLIFERATORS...

  2. 31 CFR 544.406 - Offshore transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Offshore transactions. 544.406 Section 544.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION...

  3. 31 CFR 544.406 - Offshore transactions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Offshore transactions. 544.406 Section 544.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION PROLIFERATORS...

  4. 31 CFR 544.406 - Offshore transactions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Offshore transactions. 544.406 Section 544.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION PROLIFERATORS...

  5. 31 CFR 576.407 - Offshore transactions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Offshore transactions. 576.407 Section 576.407 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRAQ STABILIZATION AND INSURGENCY SANCTIONS...

  6. 31 CFR 576.407 - Offshore transactions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Offshore transactions. 576.407 Section 576.407 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRAQ STABILIZATION AND INSURGENCY SANCTIONS...

  7. 31 CFR 576.407 - Offshore transactions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Offshore transactions. 576.407 Section 576.407 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRAQ STABILIZATION AND INSURGENCY SANCTIONS...

  8. 31 CFR 576.407 - Offshore transactions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Offshore transactions. 576.407 Section 576.407 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRAQ STABILIZATION AND INSURGENCY SANCTIONS...

  9. 31 CFR 587.406 - Offshore transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Offshore transactions. 587.406 Section 587.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FEDERAL REPUBLIC OF YUGOSLAVIA (SERBIA...

  10. 31 CFR 594.407 - Offshore transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Offshore transactions. 594.407 Section 594.407 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY GLOBAL TERRORISM SANCTIONS...

  11. Human Rights, Academic Freedom, and Offshore Academics

    ERIC Educational Resources Information Center

    Ross, Andrew

    2011-01-01

    Despite the carnage wrought on higher education by the Great Recession, evidence persists that the sector is still host to a speculator psychology. One example is the unabated stampede to set up branches and programs overseas. Colleges have many reasons to go offshore: (1) to reduce costs; (2) to build their "brands" in "emerging markets"; and (3)…

  12. Planning and evaluation parameters for offshore complexes

    NASA Technical Reports Server (NTRS)

    Sincoff, M. Z. (Editor); Dajani, J. S. (Editor)

    1976-01-01

    Issues are presented for consideration in the planning and design of offshore artificial complexes. The construction of such complexes, their social, economic, and ecological impacts, and the legal-political-institutional environments within which their development could occur, are discussed. Planning, design, and construction of near-shore complexes located off the Mid-Atlantic coast of the United States is emphasized.

  13. Solar power satellite offshore rectenna study

    NASA Astrophysics Data System (ADS)

    1980-11-01

    It was found that an offshore rectenna is feasible and cost competitive with land rectennas but that the type of rectenna which is suitable for offshore use is quite different from that specified in the present reference system. The result is a nonground plane design which minimizes the weight and greatly reduces the number of costly support towers. This preferred design is an antenna array consisting of individually encapsulated dipoles with reflectors supported on feed wires. Such a 5 GW rectenna could be built at a 50 m water depth site to withstand hurricane and icing conditions for a one time cost of 5.7 billion dollars. Subsequent units would be about 1/3 less expensive. The east coast site chosen for this study represents an extreme case of severe environmental conditions. More benign and more shallow water sites would result in lower costs. Secondary uses such as mariculture appear practical with only minor impact on the rectenna design. The potential advantages of an offshore rectenna, such as no land requirements, removal of microwave radiation from populated areas and minimal impact on the local geopolitics argue strongly that further investigation of the offshore rectenna should be vigorously pursued.

  14. Offshore blowouts, data for risk assessment

    SciTech Connect

    Holand, P.

    1995-12-31

    Blowouts are, besides gas leakages, the major contributor to the total risk for offshore installations. Therefore, the blowout risk is always included in Quantitative Risk Analyses (QRAs) of offshore installations in the Norwegian Sector of the North Sea. SINTEF Offshore Blowout Database has existed since 1984 (until 1990 it was called Marintek`s blowout database). In 1990 the responsibility of the database was transferred to SINTEF Safety and Reliability. Throughout these years the database has been used for assessing blowout risk associated to development and operation of fields offshore Norway. Six oil companies and two consultants are presently sponsoring the database. These companies are using the database when performing risk analyses. During the past three years the database has been subjected to a thorough quality improvement, both with respect to the user interface, and most important, regarding the blowout data included in the database. What is unique with this database, besides the high quality of blowout descriptions, is first that the blowout causes are categorized related to loss of primary and secondary barriers. Secondly that the user interface makes it possible to establish searches to withdraw information regarding any blowout type subjected for specific searches.

  15. 31 CFR 537.406 - Offshore transactions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Offshore transactions. 537.406 Section 537.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BURMESE SANCTIONS REGULATIONS Interpretations §...

  16. 31 CFR 541.406 - Offshore transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Offshore transactions. 541.406 Section 541.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ZIMBABWE SANCTIONS REGULATIONS...

  17. Efficient high-permeability fracturing offshore

    SciTech Connect

    Phillipi, M.; Farabee, M.

    1996-12-31

    Offshore operators can more efficiently and effectively perform high-permeability and conventional hydraulic fracture treatments by blending treatment slurries under microprocessor control, adding undiluted acid on-the-fly, and altering sand concentrations and other slurry properties instantaneously. A two-skid system has been designed with these considerations in mind. The system, which can be shipped efficiently in ISO containers, has been tested on fluids up to 210-cp viscosity and can step or ramp sand concentrations up to a maximum of 20 lb/gal. All additives, including acid treatments, are added on-the-fly; leftover additives and acids may be stored for future jobs. The system may be applied in most conditions, including offshore wells requiring conventional or high-permeability fracture treatments and certain land-based wells in remote areas where a compact skid is needed. Three significant benefits have resulted from using the compact-skid system: offshore operators have been able to ship the skid system at 20% of shipping costs of non-ISO equipment; on-the-fly mixing has prevented material waste associated with batch-mixing; and volumes pumped on actual jobs have closely matched job designs. Data have been collected from several Gulf of Mexico jobs run with the two-part skid system that has been designed for conducting hydraulic fracture treatments from offshore rigs.

  18. 31 CFR 548.406 - Offshore transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Offshore transactions. 548.406 Section 548.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BELARUS SANCTIONS REGULATIONS...

  19. 31 CFR 593.406 - Offshore transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Offshore transactions. 593.406 Section 593.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FORMER LIBERIAN REGIME OF CHARLES...

  20. 31 CFR 593.406 - Offshore transactions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Offshore transactions. 593.406 Section 593.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FORMER LIBERIAN REGIME OF CHARLES TAYLOR...

  1. Solar power satellite offshore rectenna study

    NASA Technical Reports Server (NTRS)

    1980-01-01

    It was found that an offshore rectenna is feasible and cost competitive with land rectennas but that the type of rectenna which is suitable for offshore use is quite different from that specified in the present reference system. The result is a nonground plane design which minimizes the weight and greatly reduces the number of costly support towers. This preferred design is an antenna array consisting of individually encapsulated dipoles with reflectors supported on feed wires. Such a 5 GW rectenna could be built at a 50 m water depth site to withstand hurricane and icing conditions for a one time cost of 5.7 billion dollars. Subsequent units would be about 1/3 less expensive. The east coast site chosen for this study represents an extreme case of severe environmental conditions. More benign and more shallow water sites would result in lower costs. Secondary uses such as mariculture appear practical with only minor impact on the rectenna design. The potential advantages of an offshore rectenna, such as no land requirements, removal of microwave radiation from populated areas and minimal impact on the local geopolitics argue strongly that further investigation of the offshore rectenna should be vigorously pursued.

  2. 31 CFR 549.406 - Offshore transactions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Offshore transactions. 549.406 Section 549.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY LEBANON SANCTIONS REGULATIONS Interpretations §...

  3. 31 CFR 549.406 - Offshore transactions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Offshore transactions. 549.406 Section 549.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY LEBANON SANCTIONS REGULATIONS Interpretations §...

  4. 31 CFR 549.406 - Offshore transactions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Offshore transactions. 549.406 Section 549.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY LEBANON SANCTIONS REGULATIONS Interpretations §...

  5. 31 CFR 549.406 - Offshore transactions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Offshore transactions. 549.406 Section 549.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY LEBANON SANCTIONS REGULATIONS Interpretations §...

  6. 31 CFR 537.406 - Offshore transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Offshore transactions. 537.406 Section 537.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BURMESE SANCTIONS REGULATIONS...

  7. 31 CFR 541.406 - Offshore transactions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Offshore transactions. 541.406 Section 541.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ZIMBABWE SANCTIONS REGULATIONS Interpretations §...

  8. 31 CFR 541.406 - Offshore transactions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Offshore transactions. 541.406 Section 541.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ZIMBABWE SANCTIONS REGULATIONS Interpretations §...

  9. 31 CFR 541.406 - Offshore transactions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Offshore transactions. 541.406 Section 541.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ZIMBABWE SANCTIONS REGULATIONS Interpretations §...

  10. 31 CFR 541.406 - Offshore transactions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Offshore transactions. 541.406 Section 541.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ZIMBABWE SANCTIONS REGULATIONS Interpretations §...

  11. Offshore Investments by Colleges Draw Scrutiny

    ERIC Educational Resources Information Center

    Fain, Paul; Wolverton, Brad

    2007-01-01

    Billions of dollars in untaxed, offshore investments by college endowments could be subject to taxation under a proposal being considered by the leaders of the U.S. Senate Finance Committee. The proposed change, which targets hedge funds, a popular investing strategy for many colleges, would affect the largest college endowments, including those…

  12. Mapping Seabird Sensitivity to Offshore Wind Farms

    PubMed Central

    Bradbury, Gareth; Trinder, Mark; Furness, Bob; Banks, Alex N.; Caldow, Richard W. G.; Hume, Duncan

    2014-01-01

    We present a Geographic Information System (GIS) tool, SeaMaST (Seabird Mapping and Sensitivity Tool), to provide evidence on the use of sea areas by seabirds and inshore waterbirds in English territorial waters, mapping their relative sensitivity to offshore wind farms. SeaMaST is a freely available evidence source for use by all connected to the offshore wind industry and will assist statutory agencies in assessing potential risks to seabird populations from planned developments. Data were compiled from offshore boat and aerial observer surveys spanning the period 1979–2012. The data were analysed using distance analysis and Density Surface Modelling to produce predicted bird densities across a grid covering English territorial waters at a resolution of 3 km×3 km. Coefficients of Variation were estimated for each grid cell density, as an indication of confidence in predictions. Offshore wind farm sensitivity scores were compiled for seabird species using English territorial waters. The comparative risks to each species of collision with turbines and displacement from operational turbines were reviewed and scored separately, and the scores were multiplied by the bird density estimates to produce relative sensitivity maps. The sensitivity maps reflected well the amassed distributions of the most sensitive species. SeaMaST is an important new tool for assessing potential impacts on seabird populations from offshore development at a time when multiple large areas of development are proposed which overlap with many seabird species’ ranges. It will inform marine spatial planning as well as identifying priority areas of sea usage by marine birds. Example SeaMaST outputs are presented. PMID:25210739

  13. Mapping seabird sensitivity to offshore wind farms.

    PubMed

    Bradbury, Gareth; Trinder, Mark; Furness, Bob; Banks, Alex N; Caldow, Richard W G; Hume, Duncan

    2014-01-01

    We present a Geographic Information System (GIS) tool, SeaMaST (Seabird Mapping and Sensitivity Tool), to provide evidence on the use of sea areas by seabirds and inshore waterbirds in English territorial waters, mapping their relative sensitivity to offshore wind farms. SeaMaST is a freely available evidence source for use by all connected to the offshore wind industry and will assist statutory agencies in assessing potential risks to seabird populations from planned developments. Data were compiled from offshore boat and aerial observer surveys spanning the period 1979-2012. The data were analysed using distance analysis and Density Surface Modelling to produce predicted bird densities across a grid covering English territorial waters at a resolution of 3 km×3 km. Coefficients of Variation were estimated for each grid cell density, as an indication of confidence in predictions. Offshore wind farm sensitivity scores were compiled for seabird species using English territorial waters. The comparative risks to each species of collision with turbines and displacement from operational turbines were reviewed and scored separately, and the scores were multiplied by the bird density estimates to produce relative sensitivity maps. The sensitivity maps reflected well the amassed distributions of the most sensitive species. SeaMaST is an important new tool for assessing potential impacts on seabird populations from offshore development at a time when multiple large areas of development are proposed which overlap with many seabird species' ranges. It will inform marine spatial planning as well as identifying priority areas of sea usage by marine birds. Example SeaMaST outputs are presented. PMID:25210739

  14. Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression.

    PubMed

    Amador, Ariadna; Wang, Yongjun; Banerjee, Subhashis; Kameneka, Theodore M; Solt, Laura A; Burris, Thomas P

    2016-01-01

    The nuclear receptors REV-ERBα and REV-ERBβ are transcription factors that play pivotal roles in the regulation of the circadian rhythm and various metabolic processes. The circadian rhythm is an endogenous mechanism, which generates entrainable biological changes that follow a 24-hour period. It regulates a number of physiological processes, including sleep/wakeful cycles and feeding behaviors. We recently demonstrated that REV-ERB-specific small molecules affect sleep and anxiety. The orexinergic system also plays a significant role in mammalian physiology and behavior, including the regulation of sleep and food intake. Importantly, orexin genes are expressed in a circadian manner. Given these overlaps in function and circadian expression, we wanted to determine whether the REV-ERBs might regulate orexin. We found that acute in vivo modulation of REV-ERB activity, with the REV-ERB-specific synthetic ligand SR9009, affects the circadian expression of orexinergic genes in mice. Long term dosing with SR9009 also suppresses orexinergic gene expression in mice. Finally, REV-ERBβ-deficient mice present with increased orexinergic transcripts. These data suggest that the REV-ERBs may be involved in the repression of orexinergic gene expression. PMID:26963516

  15. Protective efficacy of a recombinant BAC clone of Marek's disease virus containing REV-LTR

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Insertion of reticuloendotheliosis virus (REV) long-terminal repeat (LTR) into a bacterial artificial chromosome (BAC) clone of a very virulent strain of Marek’s disease (MD) virus (MDV), Md5 (Kim et al, 2011) rendered the resultant recombinant virus termed rMd5 REV-LTR BAC fully attenuated at passa...

  16. Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

    PubMed Central

    Woldt, Estelle; Sebti, Yasmine; Solt, Laura A.; Duhem, Christian; Lancel, Steve; Eeckhoute, Jérôme; Hesselink, Matthijs K.C.; Paquet, Charlotte; Delhaye, Stéphane; Shin, Youseung; Kamenecka, Theodore M.; Schaart, Gert; Lefebvre, Philippe; Nevière, Rémi; Burris, Thomas P.; Schrauwen, Patrick; Staels, Bart; Duez, Hélène

    2013-01-01

    The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism, adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-α is highly expressed in oxidative skeletal muscle and plays a role in mitochondrial biogenesis and oxidative function, in gain- and loss-of function studies. Rev-erb-α-deficiency in skeletal muscle leads to reduced mitochondrial content and oxidative function, resulting in compromised exercise capacity. This phenotype was recapitulated in isolated fibers and in muscle cells upon Rev-erbα knock-down, while Rev-erb-α over-expression increased the number of mitochondria with improved respiratory capacity. Rev-erb-α-deficiency resulted in deactivation of the Stk11–Ampk–Sirt1–Ppargc1-α signaling pathway, whereas autophagy was up-regulated, resulting in both impaired mitochondrial biogenesis and increased clearance. Muscle over-expression or pharmacological activation of Rev-erb-α increased respiration and exercise capacity. This study identifies Rev-erb-α as a pharmacological target which improves muscle oxidative function by modulating gene networks controlling mitochondrial number and function. PMID:23852339

  17. Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression

    PubMed Central

    Amador, Ariadna; Wang, Yongjun; Banerjee, Subhashis; Kameneka, Theodore M.; Solt, Laura A.; Burris, Thomas P.

    2016-01-01

    The nuclear receptors REV-ERBα and REV-ERBβ are transcription factors that play pivotal roles in the regulation of the circadian rhythm and various metabolic processes. The circadian rhythm is an endogenous mechanism, which generates entrainable biological changes that follow a 24-hour period. It regulates a number of physiological processes, including sleep/wakeful cycles and feeding behaviors. We recently demonstrated that REV-ERB-specific small molecules affect sleep and anxiety. The orexinergic system also plays a significant role in mammalian physiology and behavior, including the regulation of sleep and food intake. Importantly, orexin genes are expressed in a circadian manner. Given these overlaps in function and circadian expression, we wanted to determine whether the REV-ERBs might regulate orexin. We found that acute in vivo modulation of REV-ERB activity, with the REV-ERB-specific synthetic ligand SR9009, affects the circadian expression of orexinergic genes in mice. Long term dosing with SR9009 also suppresses orexinergic gene expression in mice. Finally, REV-ERBβ-deficient mice present with increased orexinergic transcripts. These data suggest that the REV-ERBs may be involved in the repression of orexinergic gene expression. PMID:26963516

  18. Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.

    PubMed

    Tamura, Satoru; Fujitani, Toshiaki; Kaneko, Masafumi; Murakami, Nobutoshi

    2010-06-15

    By use of the fission yeast expressing the model fusion protein comprised of GST, SV40 T antigen NLS, GFP, and Rev-NES in the bioassay, the prenylcoumarin osthol (1) was disclosed as the new Rev-export inhibitor from the MeOH extract of Cnidii Monnieris Fructus. Furthermore, 1 was also found to inhibit export the genuine Rev in HeLa cells by indirect fluorescent antibody technique. By the competitive experiment using the biotinylated probe 3, osthol (1) was revealed to inhibit nuclear export of Rev through a NES non-antagonistic mode. Structure-activity relationship analysis of several analogs of 1 clarified that both prenyl side chain and double bond adjacent to the lactone carbonyl residue play an important role in the Rev-export inhibitory potency of 1. PMID:20493693

  19. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3

    SciTech Connect

    Kula, Anna; Gharu, Lavina; Marcello, Alessandro

    2013-01-20

    Human immunodeficiency virus gene expression and replication are regulated at several levels. Incompletely spliced viral RNAs and full-length genomic RNA contain the RRE element and are bound by the viral trans-acting protein Rev to be transported out of the nucleus. Previously we found that the nuclear matrix protein MATR3 was a cofactor of Rev-mediated RNA export. Here we show that the pleiotropic protein PSF binds viral RNA and is associated with MATR3. PSF is involved in the maintenance of a pool of RNA available for Rev activity. However, while Rev and PSF bind the viral pre-mRNA at the site of viral transcription, MATR3 interacts at a subsequent step. We propose that PSF and MATR3 define a novel pathway for RRE-containing HIV-1 RNAs that is hijacked by the viral Rev protein.

  20. The optimisation, design and verification of feed horn structures for future Cosmic Microwave Background missions

    NASA Astrophysics Data System (ADS)

    McCarthy, Darragh; Trappe, Neil; Murphy, J. Anthony; O'Sullivan, Créidhe; Gradziel, Marcin; Doherty, Stephen; Huggard, Peter G.; Polegro, Arturo; van der Vorst, Maarten

    2016-05-01

    In order to investigate the origins of the Universe, it is necessary to carry out full sky surveys of the temperature and polarisation of the Cosmic Microwave Background (CMB) radiation, the remnant of the Big Bang. Missions such as COBE and Planck have previously mapped the CMB temperature, however in order to further constrain evolutionary and inflationary models, it is necessary to measure the polarisation of the CMB with greater accuracy and sensitivity than before. Missions undertaking such observations require large arrays of feed horn antennas to feed the detector arrays. Corrugated horns provide the best performance, however owing to the large number required (circa 5000 in the case of the proposed COrE+ mission), such horns are prohibitive in terms of thermal, mechanical and cost limitations. In this paper we consider the optimisation of an alternative smooth-walled piecewise conical profiled horn, using the mode-matching technique alongside a genetic algorithm. The technique is optimised to return a suitable design using efficient modelling software and standard desktop computing power. A design is presented showing a directional beam pattern and low levels of return loss, cross-polar power and sidelobes, as required by future CMB missions. This design is manufactured and the measured results compared with simulation, showing excellent agreement and meeting the required performance criteria. The optimisation process described here is robust and can be applied to many other applications where specific performance characteristics are required, with the user simply defining the beam requirements.

  1. Complete Greenberger-Horne-Zeilinger state analyzer using hyper-entanglement

    NASA Astrophysics Data System (ADS)

    Wang, Jia-Ming; Zhu, Meng-Zheng; Ye, Liu

    2016-02-01

    In this paper, we design a scheme where a polarization Greenberger-Horne-Zeilinger (GHZ) state can be completely and deterministically distinguished by adopting linear momentum degree of freedom as the ancillary qubits or change of roles between the momentum and polarization degrees of freedom. Two ways for distinguishing three-photon GHZ state can be achieved in just one quantum circuit.

  2. Building a Beetle: How Larval Environment Leads to Adult Performance in a Horned Beetle

    PubMed Central

    Reaney, Leeann T.; Knell, Robert J.

    2015-01-01

    The link between the expression of the signals used by male animals in contests with the traits which determine success in those contests is poorly understood. This is particularly true in holometabolous insects such as horned beetles where signal expression is determined during metamorphosis and is fixed during adulthood, whereas performance is influenced by post-eclosion feeding. We used path analysis to investigate the relationships between larval and adult nutrition, horn and body size and fitness-related traits such as strength and testes mass in the horned beetle Euoniticellus intermedius. In males weight gain post-eclosion had a central role in determining both testes mass and strength. Weight gain was unaffected by adult nutrition but was strongly correlated with by horn length, itself determined by larval resource availability, indicating strong indirect effects of larval nutrition on the adult beetle’s ability to assimilate food and grow tissues. Female strength was predicted by a simple path diagram where strength was determined by eclosion weight, itself determined by larval nutrition: weight gain post-eclosion was not a predictor of strength in this sex. Based on earlier findings we discuss the insulin-like signalling pathway as a possible mechanism by which larval nutrition could affect adult weight gain and thence traits such as strength. PMID:26244874

  3. Limit quantum efficiency for violation of Clauser-Horne inequality for qutrits

    SciTech Connect

    Genovese, M.

    2005-05-15

    In this paper we present the results of numerical calculations about the minimal value of detection efficiency for violating the Clauser-Horne inequality for qutrits. Our results show how the use of nonmaximally entangled states greatly improves this limit with respect to maximally entangled ones. A stronger resistance to noise is also found.

  4. 76 FR 53295 - Unexpected Urgent Refugee and Migration Needs Related to the Horn of Africa

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ... Federal Register. (Presidential Sig.) THE WHITE HOUSE, Washington, August 8, 2011 [FR Doc. 2011-21958... Urgent Refugee and Migration Needs Related to the Horn of Africa Presidential Determination No. 2011-13... Africa Memorandum for the Secretary of State By the authority vested in me as President by...

  5. Control of glutamatergic neurotransmission in the rat spinal dorsal horn by the nucleoside transporter ENT1.

    PubMed

    Ackley, Michael A; Governo, Ricardo J M; Cass, Carol E; Young, James D; Baldwin, Stephen A; King, Anne E

    2003-04-15

    Adenosine modulates nociceptive processing in the superficial dorsal horn of the spinal cord. In other tissues, membrane transporters influence profoundly the extracellular levels of adenosine. To investigate the putative role of nucleoside transporters in the regulation of excitatory synaptic transmission in the dorsal horn, we employed immunohistochemistry and whole-cell patch-clamp recording of substantia gelatinosa neurons in slices of rat spinal cord in vitro. The rat equilibrative nucleoside transporter (rENT1) was revealed by antibody staining to be abundant in neonatal and mature dorsal horn, especially within laminae I-III. This was confirmed by immunoblots of dorsal horn homogenate. Nitrobenzylthioinosine (NBMPR), a potent non-transportable inhibitor of rENT1, attenuated synaptically evoked EPSCs onto lamina II neurons in a concentration-dependent manner. Application of an adenosine A1 antagonist 1,3-dipropyl-8-cyclopentylxanthine produced a parallel rightward shift in the NBMPR concentration-effect curve. The effects of NBMPR were partially reversed by adenosine deaminase, which facilitates the metabolic degradation of adenosine. The modulation by NBMPR of evoked EPSCs was mimicked by exogenous adenosine or the selective A1 receptor agonist, 2-chloro-N6-cyclopentyl adenosine. NBMPR reduced the frequency but not the amplitude of spontaneous miniature EPSCs and increased the paired-pulse ratio of evoked currents, an effect that is consistent with presynaptic modulation. These data provide the first direct evidence that nucleoside transporters are able to critically modulate glutamatergic synaptic transmission. PMID:12611914

  6. Electrophysiological properties of rat spinal dorsal horn neurones in vitro: calcium-dependent action potentials.

    PubMed Central

    Murase, K; Randić, M

    1983-01-01

    1. The electrophysiological properties of dorsal horn neurones have been investigated in the immature rat in vitro spinal cord slice preparation. 2. Intracellular recordings from dorsal horn neurones show that direct or orthodromic stimulation generates action potentials followed by a brief after-hyperpolarization. Synaptic potentials were elicited by the activation of primary afferent fibres in the dorsal root. 3. Input resistance for dorsal horn neurones ranged from 48 to 267 M omega, and the membrane time constant was in the range of 4-19 ms. 4. In response to strong depolarizing currents dorsal horn neurones perfused with TTX and TEA frequently exhibit a slow regenerative depolarizing potential followed by a slow after-hyperpolarization. The depolarizing potential probably results from an influx of Ca. It is blocked by low concentration Ca, Co or Mn, and enhanced by high levels of extracellular Ca. 5. There is, in addition, a low-threshold Ca-dependent response which is activated at membrane potentials more negative than -65 mV and has a maximum rate of rise at the polarization level of about -80 mV. 6. The addition of Ba or TEA to the perfusing medium provided support for the Ca-dependence of the low- and high-threshold responses, and the lack of fast inactivation of the high-threshold Ca potential. Images Plate 1 PMID:6306228

  7. Connecting Communities, Schools, and Families: An Interview with Arthur (Andy) Horne, Phd

    ERIC Educational Resources Information Center

    Ziomek-Daigle, Jolie

    2007-01-01

    Dr. Arthur (Andy) Horne completed his PhD at Southern Illinois University in 1971. He taught at Indiana State University from 1971 until 1989, during which time he served as a member of the faculty and the director of training of the APA-accredited Counseling Psychology Program. He also was a member of the AAMFT-accredited Marriage and Family…

  8. Are Cattell-Horn-Carroll Broad Ability Composite Scores Exchangeable across Batteries?

    ERIC Educational Resources Information Center

    Floyd, Randy G.; Bergeron, Renee; McCormack, Allison C.; Anderson, Janice L.; Hargrove-Owens, Gabrielle L.

    2005-01-01

    Many school psychologists use the Cattell-Horn-Carroll (CHC) theory of cognitive abilities to guide their interpretation of scores from intelligence test batteries. Some may frequently assume that composite scores purported to measure the same CHC broad abilities should be relatively similar for individuals no matter what subtests or batteries…

  9. Clauser-Horne-Shimony-Holt violation and the entropy-concurrence plane

    SciTech Connect

    Derkacz, Lukasz; Jakobczyk, Lech

    2005-10-15

    We characterize violation of Clauser-Horne-Shimony-Holt (CHSH) inequalities for mixed two-qubit states by their mixedness and entanglement. The class of states that have maximum degree of CHSH violation for a given linear entropy is also constructed.

  10. Evaluation of the VetCap® treatment method for horn fly control in cattle

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A field study was conducted to evaluate the efficacy of the VetCap® treatment method, (SmartVet Pty Ltd, Brisbane, Australia) to control horn flies infesting cattle. The VetCap® delivery system consists of a pressure (liquid CO2) driven launcher and an encapsulated insecticide (CyLence®) formulation...

  11. Mechanical support and transport system used for the neutrino horn system at Brookhaven National Laboratory

    SciTech Connect

    Walker, J.C.; Carroll, A.S.; Leonhardt, W.; Monaghan, R.; Pearson, C.; Pendzick, A.; Ryan, G.; Sandberg, J.; Sims, W.P.; Smith, G.A.

    1987-01-01

    The study of neutrinos at the Alternating Gradient Synchrotron (AGS), Brookhaven National Laboratory (BNL), requires hardware for their initiation and control. The basics consist of a target, two horns and three collimators. This paper describes the installation, support and positioning of these components within a settling concrete blockhouse.

  12. 23. H.Q. Morton photograph #47 'South Light, Fog Horn from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. H.Q. Morton photograph #47 'South Light, Fog Horn from Bluff', (view looking NE) ca. 1880. (H. Q. Morton, Photographer, 75 Westminster Street, Providence, RI. - Block Island Southeast Light, Spring Street & Mohegan Trail at Mohegan Bluffs, New Shoreham, Washington County, RI

  13. Horn antenna design studies. Citations from the International Aerospace Abstract data base

    NASA Technical Reports Server (NTRS)

    Gallagher, M. K.

    1980-01-01

    These citations from the international literature describe the antenna radiation patterns, polarization characteristics, wave propagation, noise temperature, wave diffraction, and wideband communication of various horn antennas. This updated bibliography contains 217 citations, 63 of which are new entries to the previous edition.

  14. A Ghoulish Inconsistency: A Comment on Tim Keller's "The National Implications of "Cain v. Horne""

    ERIC Educational Resources Information Center

    Schoenig, John

    2010-01-01

    Tim Keller's article insightfully explores the flawed legal reasoning behind and potentially pernicious consequences of the Arizona Supreme Court's 2009 "Cain vs. Horne" ruling. He carefully examines the two fundamental flaws in the court's interpretative methodology: a failure to engage in a straightforward textual analysis of Arizona's Blaine…

  15. Survival and fate of Salmonella enterica serovar Montevideo in adult Horn Flies (Diptera: Muscidae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Contamination of cattle peripheral lymph nodes with Salmonella enterica is proposed to occur via a transdermal route of entry. If so, bacteria may be introduced to cattle by biting arthropods. Biting flies, such as horn flies (Haematobia irritans irritans (L.); Diptera: Muscidae), are intriguing ca...

  16. The Court versus Consent Decrees? Schools, "Horne v. Flores" and Judicial Strategies of Institutional Reform Litigation

    ERIC Educational Resources Information Center

    Chilton, Bradley; Chwialkowski, Paul

    2014-01-01

    Is the U.S. Supreme Court inviting litigants to take aim at unraveling injunctions in institutional reform litigation--especially consent decrees in the schools? In "Horne v. Flores" (2009), the court remanded a 17-year-old school reform case to a federal judge with orders to look beyond consent decrees on financing, reducing class…

  17. Overstated Optimism: Arizona's Structured English Immersion Program under "Horne v. Flores"

    ERIC Educational Resources Information Center

    Mora, Jill Kerper

    2010-01-01

    This article is an analysis of the educational implications of the Supreme Court (USSC) decision in "Horne v. Flores" (2009). The USSC remanded the Arizona case to the lower court, requiring a rehearing of petitioners' request for relief from the court's oversight of AZ's "structured English immersion" (SEI) program mandated under HB2064. The…

  18. Unruptured rudimentary horn pregnancy presenting with acute haemoperitoneum with combined intrauterine pregnancy: A case report

    PubMed Central

    Lallar, Meenakshi; Nandal, Rajesh; Sharma, Deepak

    2015-01-01

    Background: The incidence of rudimentary heterotopic uterine horn pregnancy varies from 1:76,000 to 1:140,000. However the incidence of twin pregnancy i.e. intrauterine pregnancy in unicornuate uterus and its associated rudimentary horn pregnancy is estimated to be around 1 in 10 million gestations. Case: Here, we present 19 year old pramigravida women with acute haemoperitoneum with diagnosis of unruptured rudimentary horn pregnancy combined by intrauterine pregnancy. The patient was managed with emergency laparatomy and resuscitation. Rudimentary horn containing foetus was excised and intrauterine pregnancy was left untouched. The intrauterine pregnancy was supported with progesterone and tocolytics and the patient delivered a newborn of 2.8 kg through spontaneous labor at 37 weeks of gestation. Conclusion: Heterotopic pregnancies incidence have increased in comparison to past and there should be high level of suspicion for this rare event as this is often associated with high maternal and fetal morbidity and mortality where diagnosis is difficult and challenging and easily missed. . Timely intervention provides survival of intrauterine pregnancy in case of twin pregnancy, even in low resource settings where usually the diagnosis is missed before acute event. PMID:25653676

  19. Advanced pregnancy loss in the rudimentary horn of an undiagnosed unicornuate uterus.

    PubMed

    Perez-Medina, Tirso; García-Andrade, Carmen; Bajo-Arenas, José

    2009-06-01

    A case of advanced pregnancy loss in the rudimentary horn of a unicornuate uterus is presented herein. The unknown uterine malformation and advanced pregnancy resulted in the condition being incorrectly diagnosed on ultrasound. After a failed attempt at dilatation and curettage, a correct diagnosis was made and proper treatment was given during salvage laparotomy performed for arising complications (coagulopathy). PMID:19527403

  20. An autopsy report on a ruptured rudimentary horn (uterine anomaly) with ectopic pregnancy.

    PubMed

    Hirose, Izumi; Harada, Kazuki; Kuroda, Ryohei; Ishii, Yasuhiro; Nakajima, Makoto; Kamei, Yoshimasa; Takazawa, Yutaka; Yoshida, Ken-ichi

    2013-01-10

    The rudimentary horn is a rare developmental anomaly of the Müllerian duct. Ectopic pregnancy in the rudimentary horn is estimated to occur in one out of 76,000-150,000 pregnancies. A 30-year-old primigravida suddenly collapsed after 3 days of continuous abdominal pain. Emergency laparotomy revealed a massive intraperitoneal hemorrhage and fetal demise. The growth of the fetus after 19 weeks of gestation is believed to have caused the rudimentary horn rupture, thereby rapidly leading to hemorrhagic shock in the mother and ischemic death in the fetus. This is the first autopsy report on maternal death due to the rudimentary horn or other Müllerian duct anomalies, which emphasizes the need for forensic pathologists to consider this condition as a possible cause of unexpected death in fertile women. In addition, it is very important for clinicians to detect Müllerian duct anomalies by sonography during routine obstetric examinations, and promptly diagnose anomaly related ectopic pregnancies in women displaying symptoms of an acute abdomen, intraperitoneal hemorrhage, or shock in the emergency practice. PMID:23265443

  1. Implementation of Linus Programme Based on the Model of Van Meter and Van Horn

    ERIC Educational Resources Information Center

    Sani, Nazariyah bt; Idris, Abdul Rahman

    2013-01-01

    The purpose of this study is to identify the understanding of school leaders on the implementation of LINUS programme that based on the features contained in the Implementation Model of Van Meter and Van Horn (1975). The study was carried out in the form of qualitative method and particularly, the multiple case studies that were conducted in four…

  2. Milk production traits of beef cows as affected by horn fly numbers and breed type

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pesticide resistance in horn flies indicates the need for more sustainable production systems. Cows sired by Bonsmara (BONS;n=7), Brangus (BRAN;n=13), Charolais (CHAR;n=8), Gelbvieh (GELV;n=5), Hereford (HERF;n=12), and Romosinuano (ROMO;n=8) from Brangus dams were used to determine breed difference...

  3. 9 CFR 95.11 - Bones, horns, and hoofs for trophies or museums; disinfected hoofs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Bones, horns, and hoofs for trophies or museums; disinfected hoofs. 95.11 Section 95.11 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS SANITARY CONTROL...

  4. 9 CFR 95.11 - Bones, horns, and hoofs for trophies or museums; disinfected hoofs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Bones, horns, and hoofs for trophies or museums; disinfected hoofs. 95.11 Section 95.11 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS SANITARY CONTROL...

  5. Foot-and-mouth disease virus serotype SAT 3 in long-horned Ankole calf, Uganda.

    PubMed

    Dhikusooka, Moses Tefula; Tjørnehøj, Kirsten; Ayebazibwe, Chrisostom; Namatovu, Alice; Ruhweza, Simon; Siegismund, Hans Redlef; Wekesa, Sabenzia Nabalayo; Normann, Preben; Belsham, Graham J

    2015-01-01

    After a 16-year interval, foot-and-mouth disease virus serotype SAT 3 was isolated in 2013 from an apparently healthy long-horned Ankole calf that grazed close to buffalo in Uganda. The emergent virus strain is ≈20% different in nucleotide sequence (encoding VP1 [viral protein 1]) from its closest relatives isolated previously from buffalo in Uganda. PMID:25531186

  6. Foot-and-Mouth Disease Virus Serotype SAT 3 in Long-Horned Ankole Calf, Uganda

    PubMed Central

    Dhikusooka, Moses Tefula; Tjørnehøj, Kirsten; Ayebazibwe, Chrisostom; Namatovu, Alice; Ruhweza, Simon; Siegismund, Hans Redlef; Wekesa, Sabenzia Nabalayo; Normann, Preben

    2015-01-01

    After a 16-year interval, foot-and-mouth disease virus serotype SAT 3 was isolated in 2013 from an apparently healthy long-horned Ankole calf that grazed close to buffalo in Uganda. The emergent virus strain is ≈20% different in nucleotide sequence (encoding VP1 [viral protein 1]) from its closest relatives isolated previously from buffalo in Uganda. PMID:25531186

  7. Effects of choke-load position on radiation properties in double-choked small horn antennas

    NASA Astrophysics Data System (ADS)

    Miyata, K.; Suzuki, M.

    1983-04-01

    Results of experiments conducted for the purpose of investigating the effects of the choke position on the beam circularity and the crosspolarisation properties in double-choked small horn antennas are presented. It is shown that the value of the maximum crosspolarisation can be suppressed below -37 dB by properly displacing the choke position from the circular waveguide aperture.

  8. Influence of permethrin, diazinon and ivermectin treatments on insecticide resistance in the horn fly (Diptera: Muscidae).

    PubMed

    Byford, R L; Craig, M E; DeRouen, S M; Kimball, M D; Morrison, D G; Wyatt, W E; Foil, L D

    1999-01-01

    The history of insecticide resistance in the horn fly, Haematobia irritans, and the relationship between the characteristics of horn fly biology and insecticide use on resistance development is discussed. Colonies of susceptible horn flies were selected for resistance with six insecticide treatment regimens: continuous single use of permethrin, diazinon and ivermectin: permethrin-diazinon (1:2) mixture; and permethrin-diazinon and permethrin-ivermectin rotation (4-month cycle). Under laboratory conditions, resistance developed during generations 21, 31 and 30 to permethrin, diazinon and ivermectin, respectively. The magnitude of resistance ranged from < 3-fold with ivermectin to 1470-fold with permethrin. Field studies demonstrated that use of a single class of insecticidal ear tag during the horn-fly season resulted in product failure within 3-4 years for pyrethroids and organophosphates, respectively. In laboratory studies, use of alternating insecticides or a mixture of insecticides delayed the onset of resistance for up to 12 generations and reduced the magnitude of pyrethroid resistance. In field studies, yearly alternated use of pyrethroids and organophosphates did not slow or reverse pyrethroid resistance (Barros et al., unpublished data), while a 2-year alternated use with organophosphates resulted in partial reversion of pyrethroid resistance. When pyrethroid and organophosphate ear tags were used in a mosaic strategy at two different locations, efficacy of products did not change during a 3-year period. PMID:10048825

  9. Low threshold primary afferent drive onto GABAergic interneurons in the superficial dorsal horn of the mouse

    PubMed Central

    Daniele, Claire A.; MacDermott, Amy B.

    2010-01-01

    Inhibition in the spinal cord dorsal horn is crucial for maintaining separation of touch and pain modalities. Disruption of this inhibition results in allodynia, allowing low threshold drive onto pain and temperature sensitive projection neurons. This low threshold excitatory pathway is normally under strong inhibition. We hypothesized that superficial dorsal horn inhibitory neurons, which would be ideally located to suppress low threshold drive onto projection neurons in a feedforward manner, are driven by low threshold input. In addition, because disinhibition-induced allodynia shares some features with the immature dorsal horn such as elevated sensitivity to low threshold input, we also questioned whether low threshold drive onto inhibitory neurons changes during postnatal maturation. To investigate these questions, slices were made at different ages from transgenic mice with EGFP expression in GABAergic neurons and whole cell recordings were made from these fluorescent neurons. Evoked synaptic activity was measured in response to electrical stimulation of the dorsal root. We demonstrate that Aβ fibers activate a significant proportion of superficial dorsal horn GABAergic neurons. This occurs with similar excitatory synaptic drive throughout postnatal maturation, but with a greater prevalence at younger ages. These GABAergic neurons are well situated to contribute to suppressing low threshold activation of output projection neurons. In addition, the majority of these GABAergic neurons also had convergent input from high threshold fibers, suggesting that this novel subclass of GABAergic neurons is important for gating innocuous as well as noxious information. PMID:19158295

  10. A history of the oil business in the Big Horn Basin, Wyoming

    SciTech Connect

    Hares, C.J.

    1988-01-01

    This paper provides a historical account of the discovery and development of the Big Horn Basin. It discusses the exploration and drilling history; government purchases and leasing programs; development of geophysical survey techniques; oil and gas market history; impacts of World War II; and production history.

  11. Solitary Angiokeratoma Presenting as Cutaneous Horn over the Prepuce: A Rare Appearance

    PubMed Central

    Agarwala, Manoj Kumar; Mukhopadhyay, Sramana; Sekhar, M Raja; Menon, Aswathy; Peter, CV Dincy

    2016-01-01

    We present a case of a 47-year-old man with 4 months history of conical growth on the prepuce with a progressive increase in size. The patient had been treated for seminoma a decade ago. Histopathology of the growth showed features of angiokeratoma. It is unusual for angiokeratoma to masquerade as a cutaneous horn. PMID:27057048

  12. Laboratory evaluation of novaluron for controlling larval horn flies, house flies, and stable flies (Diptera: Muscidae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A granular formulation of novaluron (Novaluron 0.2G, 0.2% AI), a newer benzoylphenyl urea insecticide, was evaluated for its efficacy in controlling the larval stage of horn flies, Haematobia irritans (Linnaeus), house flies, Musca domestica Linnaeus, and stable flies, Stomoxys calcitrans (Linnaeus)...

  13. Radioactivity levels in mussels and sediments of the Golden Horn by the Bosphorus Strait, Marmara Sea.

    PubMed

    Kılıç, Önder; Belivermiş, Murat; Gözel, Furkan; Carvalho, Fernando P

    2014-09-15

    The Golden Horn is an estuary located in the center of İstanbul receiving freshwater discharges from two creeks and connecting to the Bosphorus Strait. Activity concentrations of natural and artificial radionuclides were determined in mussels (Mytilus galloprovincialis) and sediments from the Golden Horn sampled in February 2012. Mean activity concentrations of (137)Cs, (40)K, (226)Ra, (228)Ra, (210)Po and (210)Pb in the mussels were determined at 1.03±0.23, 389±41.6, 2.61±1.23, not detected (ND), 91.96±37.88 and 11.48±4.85 Bq kg(-1), respectively. In sediments, it was observed that (137)Cs, (40)K, (226)Ra, (228)Ra, (210)Po and (210)Pb activity concentrations in<63 μm particle fraction of sediment were generally higher than those determined in mussels. Po-210 and (210)Po/(210)Pb ratios in mussels from the Golden Horn were much lower than in mussels from other coastal regions and this was related to low plankton productivity and eutrophication of the Golden Horn. PMID:25023437

  14. RevBayes: Bayesian Phylogenetic Inference Using Graphical Models and an Interactive Model-Specification Language

    PubMed Central

    Höhna, Sebastian; Landis, Michael J.

    2016-01-01

    Programs for Bayesian inference of phylogeny currently implement a unique and fixed suite of models. Consequently, users of these software packages are simultaneously forced to use a number of programs for a given study, while also lacking the freedom to explore models that have not been implemented by the developers of those programs. We developed a new open-source software package, RevBayes, to address these problems. RevBayes is entirely based on probabilistic graphical models, a powerful generic framework for specifying and analyzing statistical models. Phylogenetic-graphical models can be specified interactively in RevBayes, piece by piece, using a new succinct and intuitive language called Rev. Rev is similar to the R language and the BUGS model-specification language, and should be easy to learn for most users. The strength of RevBayes is the simplicity with which one can design, specify, and implement new and complex models. Fortunately, this tremendous flexibility does not come at the cost of slower computation; as we demonstrate, RevBayes outperforms competing software for several standard analyses. Compared with other programs, RevBayes has fewer black-box elements. Users need to explicitly specify each part of the model and analysis. Although this explicitness may initially be unfamiliar, we are convinced that this transparency will improve understanding of phylogenetic models in our field. Moreover, it will motivate the search for improvements to existing methods by brazenly exposing the model choices that we make to critical scrutiny. RevBayes is freely available at http://www.RevBayes.com. [Bayesian inference; Graphical models; MCMC; statistical phylogenetics.] PMID:27235697

  15. RevBayes: Bayesian Phylogenetic Inference Using Graphical Models and an Interactive Model-Specification Language.

    PubMed

    Höhna, Sebastian; Landis, Michael J; Heath, Tracy A; Boussau, Bastien; Lartillot, Nicolas; Moore, Brian R; Huelsenbeck, John P; Ronquist, Fredrik

    2016-07-01

    Programs for Bayesian inference of phylogeny currently implement a unique and fixed suite of models. Consequently, users of these software packages are simultaneously forced to use a number of programs for a given study, while also lacking the freedom to explore models that have not been implemented by the developers of those programs. We developed a new open-source software package, RevBayes, to address these problems. RevBayes is entirely based on probabilistic graphical models, a powerful generic framework for specifying and analyzing statistical models. Phylogenetic-graphical models can be specified interactively in RevBayes, piece by piece, using a new succinct and intuitive language called Rev. Rev is similar to the R language and the BUGS model-specification language, and should be easy to learn for most users. The strength of RevBayes is the simplicity with which one can design, specify, and implement new and complex models. Fortunately, this tremendous flexibility does not come at the cost of slower computation; as we demonstrate, RevBayes outperforms competing software for several standard analyses. Compared with other programs, RevBayes has fewer black-box elements. Users need to explicitly specify each part of the model and analysis. Although this explicitness may initially be unfamiliar, we are convinced that this transparency will improve understanding of phylogenetic models in our field. Moreover, it will motivate the search for improvements to existing methods by brazenly exposing the model choices that we make to critical scrutiny. RevBayes is freely available at http://www.RevBayes.com [Bayesian inference; Graphical models; MCMC; statistical phylogenetics.]. PMID:27235697

  16. Structure of REV-ERBβ Ligand-binding Domain Bound to a Porphyrin Antagonist*

    PubMed Central

    Matta-Camacho, Edna; Banerjee, Subhashis; Hughes, Travis S.; Solt, Laura A.; Wang, Yongjun; Burris, Thomas P.; Kojetin, Douglas J.

    2014-01-01

    REV-ERBα and REV-ERBβ are members of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors that play important roles in the regulation of circadian physiology, metabolism, and immune function. Although the REV-ERBs were originally characterized as orphan receptors, recent studies have demonstrated that they function as receptors for heme. Here, we demonstrate that cobalt protoporphyrin IX (CoPP) and zinc protoporphyrin IX (ZnPP) are ligands that bind directly to the REV-ERBs. However, instead of mimicking the agonist action of heme, CoPP and ZnPP function as antagonists of REV-ERB function. This was unexpected because the only distinction between these ligands is the metal ion that is coordinated. To understand the structural basis by which REV-ERBβ can differentiate between a porphyrin agonist and antagonist, we characterized the interaction between REV-ERBβ with heme, CoPP, and ZnPP using biochemical and structural approaches, including x-ray crystallography and NMR. The crystal structure of CoPP-bound REV-ERBβ indicates only minor conformational changes induced by CoPP compared with heme, including the porphyrin ring of CoPP, which adopts a planar conformation as opposed to the puckered conformation observed in the heme-bound REV-ERBβ crystal structure. Thus, subtle changes in the porphyrin metal center and ring conformation may influence the agonist versus antagonist action of porphyrins and when considered with other studies suggest that gas binding to the iron metal center heme may drive alterations in REV-ERB activity. PMID:24872411

  17. The orphan receptor Rev-erbα gene is a target of the circadian clock pacemaker

    PubMed Central

    Triqueneaux, Gérard; Thenot, Sandrine; Kakizawa, Tomoko; Antoch, Marina P; Safi, Rachid; Takahashi, Joseph S; Delaunay, Franck; Laudet, Vincent

    2013-01-01

    Rev-erbα is a ubiquitously expressed orphan nuclear receptor which functions as a constitutive transcriptional repressor and is expressed in vertebrates according to a robust circadian rhythm. We report here that two Rev-erbα mRNA isoforms, namely Rev-erbα1 and Rev-erbα2, are generated through alternative promoter usage and that both show a circadian expression pattern in an in vitro system using serum-shocked fibroblasts. Both promoter regions P1 (Rev-erbα1) and P2 (Rev-erbα2) contain several E-box DNA sequences, which function as response elements for the core circadian-clock components: CLOCK and BMAL1. The CLOCK–BMAL1 heterodimer stimulates the activity of both P1 and P2 promoters in transient transfection assay by 3–6-fold. This activation was inhibited by the overexpression of CRY1, a component of the negative limb of the circadian transcriptional loop. Critical E-box elements were mapped within both promoters. This regulation is conserved in vertebrates since we found that the CLOCK–BMAL1 heterodimer also regulates the zebrafish Rev-erbα gene. In line with these data Rev-erbα circadian expression was strongly impaired in the livers of Clock mutant mice and in the pineal glands of zebrafish embryos treated with Clock and Bmal1 antisense oligonucleotides. Together these data demonstrate that CLOCK is a critical regulator of Rev-erbα circadian gene expression in evolutionarily distant vertebrates and suggest a role for Rev-erbα in the circadian clock output. PMID:15591021

  18. Ultrasonic actuators: Remote strain measurements, high strain horns and ultrasonic chromatography

    NASA Astrophysics Data System (ADS)

    Lee, Chung Hoon

    In this thesis, optical diffraction strain measurement, silicon-based ultrasonic horn actuators for thin film testing, and mufluidic assay systems are presented. Optical ultrasonic strain measurement: Using optical diffraction gratings integrated on a PZT/silicon laminate actuator, the strain on the actuator was optically and remotely measured. The methodology, limitations, analytical and numerical (ANSYS) analysis are presented. This technology of diffraction grating for ultrasonic strain measurements could lead to an instrument useful for remote monitoring of strain on MEMS sensors. Design of high efficiency silicon-based ultrasonic horn, and their fabrication for thin film testing under cyclic load: A detailed ultrasonic horn design and its analysis are resented. For this application a Gaussian horn is utilized. Most ultrasonic horns have a single point maximum strain point along the horn resulting in strain gradient at all points. For the purpose of straining thin films it is desirable to have areas of spatially constant strain fields. Remarkably, the Gaussian horn has a constant strain area suitable for thin film testing. High strain values can lead to testing not only fatigue, but also fracture of thin films. We feel that the ability to generate constant ultrasonic strain areas on silicon is a technique suitable for industrial and academic material characterization. A portable high-intensity ultrasonic actuator for mufluidic separation (ultrasonic chromatography): Micro-particle manipulation in a liquid using ultrasonic fields in a micro-channel, principle of operation, and analysis are presented. Beads of different sizes could be separated within an optically viewable aperture (˜100 mum). It is found that the separation occurs due to ultrasonic radiation force and a new inertial force, acting on the beads. The key mechanism of focusing beads at the nodes of ultrasonic standing waves, and the origin of the inertial force for the separation are described. The

  19. Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells

    SciTech Connect

    Ramakrishnan, Sathiya N.; Lau, Patrick; Crowther, Lisa M.; Cleasby, Mark E.; Millard, Susan; Leong, Gary M.; Cooney, Gregory J.; Muscat, George E.O.

    2009-10-30

    The nuclear hormone receptor, Rev-erb beta operates as a transcriptional silencer. We previously demonstrated that exogenous expression of Rev-erb{beta}{Delta}E in skeletal muscle cells increased Srebp-1c mRNA expression. We validated these in vitro observations by injection of an expression vector driving Rev-erb{beta}{Delta}E expression into mouse tibialis muscle that resulted in increased Srebp-1c mRNA expression. Paradoxically, Rev-erb{beta} siRNA expression in skeletal muscle cells repressed Srebp-1c expression, and indicated that Rev-erb{beta} expression was necessary for Srebp-1c expression. ChIP analysis demonstrated that Rev-erb{beta} was recruited to the Srebp-1c promoter. Moreover, Rev-erb{beta} trans-activated the Srebp-1c promoter, in contrast, Rev-erb{beta} efficiently repressed the Rev-erb{alpha} promoter, a previously characterized target gene. Finally, treatment with the Rev-erb agonist (hemin) (i) increased the trans-activation of the Srebp-1c promoter by Rev-erb{beta}; and (ii) increased Rev-erb{beta} and Srebp-1c mRNA expression. These data suggest that Rev-erb{beta} has the potential to activate gene expression, and is a positive regulator of Srebp-1c, a regulator of lipogenesis.

  20. A new horned dinosaur reveals convergent evolution in cranial ornamentation in Ceratopsidae.

    PubMed

    Brown, Caleb M; Henderson, Donald M

    2015-06-15

    Ceratopsid (horned) dinosaurs are an iconic group of large-bodied, quadrupedal, herbivorous dinosaurs that evolved in the Late Cretaceous and were largely restricted to western North America [1-5]. Ceratopsids are easily recognized by their cranial ornamentation in the form of nasal and postorbital horns and frill (capped by epiossifications); these structures show high morphological disparity and also represent the largest cranial display structures known to have evolved [2, 4]. Despite their restricted occurrence in time and space, this group has one of the best fossil records within Dinosauria, showing a rapid diversification in horn and frill morphology [1]. Here a new genus and species of chasmosaurine ceratopsid is described based on a nearly complete and three-dimensionally preserved cranium recovered from the uppermost St. Mary River Formation (Maastrichtian) of southwestern Alberta. Regaliceratops peterhewsi gen. et sp. nov. exhibits many unique characters of the frill and is characterized by a large nasal horncore, small postorbital horncores, and massive parietal epiossifications. Cranial morphology, particularly the epiossifications, suggests close affinity with the late Campanian/early Maastrichian taxon Anchiceratops, as well as with the late Maastrichtian taxon Triceratops. A median epiparietal necessitates a reassessment of epiossification homology and results in a more resolved phylogeny. Most surprisingly, Regaliceratops exhibits a suite of cranial ornamentations that are superficially similar to Campanian centrosaurines, indicating both exploration of novel display morphospace in Chasmosaurinae, especially Maastrichtian forms, and convergent evolution in horn morphology with the recently extinct Centrosaurinae. This marks the first time that evolutionary convergence in horn-like display structures has been demonstrated between dinosaur clades, similar to those seen in fossil and extant mammals [6]. PMID:26051892