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Sample records for ht-7 tokamak

  1. Recent Progress of HT-7U Superconducting Tokamak

    NASA Astrophysics Data System (ADS)

    Weng, Pei-de

    2002-12-01

    HT-7U is a superconducting tokamak, which is being constructed in Institute of Plasma Physics, Chinese Academy of Sciences. The mission of the HT-7U project is to develop a scientific and engineering basis of the steady state operation of advanced tokamak. The engineering design of the device has been optimized. The R&D program is going on. Short samples of the conductor and a CS model coil were tested. All the TF and PF coils will be manufactured and tested in Institute of Plasma Physics. Therefore, a 600-meter long jacketing line for cable-in-conduit conductors along with two winding machines, a set of VPI equipment and a test facility for the TF and PF coils are ready in ASIPP now. In this paper, the recent progress of the HT-7U is described.

  2. Recent experiments in the EAST and HT-7 superconducting tokamaks

    NASA Astrophysics Data System (ADS)

    Wan, Baonian; International EAST Collaborators; HT-7 Teams

    2009-10-01

    First divertor plasma configuration in Experimental Advanced Superconducting Tokamak (EAST) was obtained in the second campaign after the last IAEA meeting. To achieve long pulse diverted plasma discharges, new capabilities including the fully actively water cooled in-vessel components, current drive and heating systems, diagnostics and real-time plasma control algorithm were developed. Pre-programmed shape and feedback control of plasma position and current (RZIP) produced a variety of shaped plasma configurations, covering most of the configurations foreseen at the design stage of the machine. Control algorithm based on real-time equilibrium reconstruction and iso-flux control for the last closed magnetic flux surface (RTEFIT/ISOFLUX) has also been realized. A number of operational issues, such as plasma initiation and ramp up under constraints of superconducting coils were successfully investigated. First LHCD experiments demonstrated long pulse discharges longer than 20 s and nearly full non-inductive current drive. The physical engineering capability on the superconducting magnetic system was assessed by simulating discharges. Since the last IAEA meeting, experiments in HT-7 have been focusing on long pulse operation to support the EAST experiments on both physics and technical aspects. Long pulse discharges up to 400 s have now been achieved in HT-7. Investigation of sawtooth activities in ohmic and LHCD plasmas supports the turbulence model instead of the fast reconnection of the m = 1 magnetic island. Coexistence of electron mode and ion mode in high density ohmic plasmas has been observed by 2D ECE imaging (ECEI) in HT-7. The spectral characteristics of geodesic acoustic mode at the plasma boundary have been investigated by Langmuir probe arrays.

  3. Analysis of the Radiation Shield of HT-7U Tokamak

    NASA Astrophysics Data System (ADS)

    Huang, Qunying; Chen, Yixue

    2003-06-01

    Analysis of the radiation shield of HT-7U fusion experimental device has been presented in this contribution. An inner shield and an outer shield, is used to reduce the dose rate to the device, workers and publics. Transport calculations and analyses have been done by 3D MCNP/4C models for neutron spectrum, γ spectrum, neutron and γ dose rate levels during operation and selection of detectors. Activation calculation have been done by inventory code FISPACT to estimate the decay γ dose rate level to workers after one pulse operation of the device and the permission time for workers to get into the shield building or device to make some maintenance or replace after discharge.

  4. Data processing and analysis of the imaging Thomson scattering diagnostic system on HT-7 tokamak

    SciTech Connect

    Han Xiaofeng; Shao Chunqiang; Xi Xiaoqi; Zhao Junyu; Qing Zang; Yang Jianhua; Dai Xingxing; Shinichiro, Kado

    2013-05-15

    A high spatial resolution imaging Thomson scattering diagnostic system was developed in ASIPP (Institute of Plasma Physics, Chinese Academy of Sciences). After about one month trial running on the superconducting HT-7 (Hefei Tokamak-7) tokamak, the system was proved to be capable of measuring plasma electron temperature. The system setup and data calibration are described in this paper and then the instrument function is studied in detail, as well as the measurement capability, an electron temperature of 50 eV to 2 keV and density beyond 1 Multiplication-Sign 10{sup 19} m{sup -3}. Finally, the data processing method and experimental results are presented.

  5. Data processing and analysis of the imaging Thomson scattering diagnostic system on HT-7 tokamak.

    PubMed

    Han, Xiaofeng; Shao, Chunqiang; Xi, Xiaoqi; Zhao, Junyu; Qing, Zang; Yang, Jianhua; Dai, Xingxing; Kado, Shinichiro

    2013-05-01

    A high spatial resolution imaging Thomson scattering diagnostic system was developed in ASIPP (Institute of Plasma Physics, Chinese Academy of Sciences). After about one month trial running on the superconducting HT-7 (Hefei Tokamak-7) tokamak, the system was proved to be capable of measuring plasma electron temperature. The system setup and data calibration are described in this paper and then the instrument function is studied in detail, as well as the measurement capability, an electron temperature of 50 eV to 2 keV and density beyond 1 × 10(19) m(-3). Finally, the data processing method and experimental results are presented. PMID:23742546

  6. Soft x-ray pulse height analyzer in the HT-7 tokamak

    SciTech Connect

    Shi Yuejiang; Chen Zhongyong; Wan Baonian; Lv Bo; Hu Liqun; Lin Shiyao; Hu Qinsheng; Qian Jinping; Liu Haiqing; Liu Shengxia; Xu Yucun; Shan Jiafang; Li Jiangang

    2004-11-01

    A new soft x-ray pulse height analyzer (PHA), based on a Silicon Drift Detector (SDD) linear array consisting of 15 SDD detectors, has been installed in the HT-7 tokamak. The energy resolution of 150-180 eV at photon energy of 6 keV is achieved for the SDD with Peltier cooling. The effective time response of the SDD PHA is 50 ms. The profiles of electron temperature and the intensity of metallic impurities can be obtained with a spatial resolution of 3 cm. The performance and first experimental results from the new PHA system are presented.

  7. Cleaning of HT-7 Tokamak Exposed First Mirrors by Radio Frequency Magnetron Sputtering Plasma

    NASA Astrophysics Data System (ADS)

    Yan, Rong; Chen, Junling; Chen, Longwei; Ding, Rui; Zhu, Dahuan

    2014-12-01

    The stainless steel (SS) first mirror pre-exposed in the deposition-dominated environment of the HT-7 tokamak was cleaned in the newly built radio frequency (RF) magnetron sputtering plasma device. The deposition layer on the FM surface formed during the exposure was successfully removed by argon plasma with a RF power of about 80 W and a gas pressure of 0.087 Pa for 30 min. The total reflectivity of the mirrors was recovered up to 90% in the wavelength range of 300-800 nm, while the diffuse reflectivity showed a little increase, which was attributed to the increase of surface roughness in sputtering, and residual contaminants. The FMs made from single crystal materials could help to achieve a desired recovery of specular reflectivity in the future.

  8. Influence of Erosion and Deposition on Metallic First Mirror in HT-7 Tokamak

    NASA Astrophysics Data System (ADS)

    Chen, Ju; Yan, Rong; Chen, Junling

    2012-08-01

    Dedicated experiments in the HT-7 tokamak were performed to investigate the influence of erosion and deposition on the mirror samples. The first mirror (FM) samples made of polycrystalline (PC) stainless steel (SS), molybdenum (Mo) and tungsten (W) were fixed on a holder at an angle of 45° with respect to the horizontal plane and set at different locations with different connection lengths along the magnetic field. The optical reflectivity of the first mirror was measured by a spectrophotometer before and after plasma exposure. It was found that the surface morphology and specular reflectivity of the mirror samples after the exposure were different with respect to the different distances from the mirror surface to the last closed flux surface (LCFS) of the plasma in the tokamak. It was also found that shortening the connection length before the mirror surface would weaken the influence of the plasma erosion and impurity deposition on the mirror surface. In order to maintain the optical characteristics of the mirror surface, it is necessary to adopt the in-situ cleaning and mirror protection techniques.

  9. Heat transport analysis of the improved confinement discharge with LHW in the HT-7 tokamak

    NASA Astrophysics Data System (ADS)

    Zhang, X. M.; Shen, X.; Wan, B. N.; Wu, Z. W.; Fu, J.; Fu

    2010-04-01

    In the HT-7 tokamak, heat transport analysis is carried out for the lower hybrid current drive (LHCD) experiments. Electrons and ions are coupled and good confinement can be obtained by properly optimizating LHCD and plasma parameters. Under the conditions that the plasma current is about 220 kA, the lower hybrid wave (LHW) power is about 300 kW and the central line-averaged density is about 1.5×1013 cm-3, lower hybrid wave power deposition is off-axis. Local transport analysis illustrated that both electron and ion thermal diffusivities are decreased during the LHW phase, and the electron internal transport barriers (eITBs) are formed while been accompanied by the ion internal transport barriers (iITBs) during LHW phase. Ions are heated by electron-ion collision in the region of the barriers although the ohmic power and the LHW power were absorbed by the electrons. Both electron temperature and ion temperature are increased during the LHW phase, and in the confinement region, the electron-to-ion temperature ratio, Te/Ti varies from 2.0 ~ 2.5 during OH phase to 1.3 ~ 1.6 during LHW injected into the plasma, which shows that electron confinement is not degraded by the electron-ion collisions meanwhile ions are also confined. The energy confinement is increased from 13 ms to 25 ms due to the formation of electron and ion internal transport barries after the LHW is injected into the plasma. LHW driven current and bootstrap current contribute to 60% of the total current.

  10. The Beam Profile Calculation for Diagnostic Neutral Beam on HT-7 Tokamak

    NASA Astrophysics Data System (ADS)

    Liang, Lizhen; Hu, Chundong

    2013-10-01

    A new calculation method is introduced for convergence beam intensity. The program based on this method is prepared for beam intensity distribution and beam power calculation. Taking the HT-7 DNB as a reference, the beam profile calculated by program is similar with that of Gaussian fit of experimental data.

  11. Understanding the bursty electron cyclotron emission during a sawtooth crash in the HT-7 tokamak

    SciTech Connect

    Li, Erzhong Hu, Liqun; Chen, Kaiyun

    2014-01-15

    Bursts in electron cyclotron emission (ECE) were observed during sawtooth crashes in HT-7 in discharges with ion cyclotron resonance heating injected near the q = 1 rational surface (q is the safety factor). The local ECE measurement indicated that the bursty radiation is only observed on channels near but a little away outward from the q = 1 magnetic surface. In conjunction with the soft x-ray tomography analysis, it was determined that, for the first time, only a compression process survives in the later stage of fast magnetic reconnection but before prompt heat transport. The compression enhanced the electron radiation temperature, the increased amplitude of which agreed well with the estimation according to a kinetic compression theory model [R. J. Hastie and T. C. Hender, Nucl. Fusion 28, 585 (1988)]. This paper presents the experimental evidence that there indeed exists a transient compression phase which results in the bursty ECE radiation during a sawtooth crash.

  12. Understanding the bursty electron cyclotron emission during a sawtooth crash in the HT-7 tokamak

    NASA Astrophysics Data System (ADS)

    Li, Erzhong; Hu, Liqun; Chen, Kaiyun

    2014-01-01

    Bursts in electron cyclotron emission (ECE) were observed during sawtooth crashes in HT-7 in discharges with ion cyclotron resonance heating injected near the q = 1 rational surface (q is the safety factor). The local ECE measurement indicated that the bursty radiation is only observed on channels near but a little away outward from the q = 1 magnetic surface. In conjunction with the soft x-ray tomography analysis, it was determined that, for the first time, only a compression process survives in the later stage of fast magnetic reconnection but before prompt heat transport. The compression enhanced the electron radiation temperature, the increased amplitude of which agreed well with the estimation according to a kinetic compression theory model [R. J. Hastie and T. C. Hender, Nucl. Fusion 28, 585 (1988)]. This paper presents the experimental evidence that there indeed exists a transient compression phase which results in the bursty ECE radiation during a sawtooth crash.

  13. Observation of heat transfer across x point of the islands during sawtooth crash on the HT-7 tokamak

    NASA Astrophysics Data System (ADS)

    Sun, Youwen; Wan, Baonian; Hu, Liqun; Chen, Kaiyun; Shen, Biao; Mao, Jianshan

    2009-06-01

    It is observed that a large heat flow abruptly transfers across the x point (which can be located at both the high field side and the low field side) of the 1/1 or 2/2 magnetic islands during a sawtooth crash on the HT-7 tokamak by using tomography of the high-resolution soft-x-ray emission together with the singular value decomposition technique. Although the poloidally asymmetric heat flow contributes an m = 1 component of perturbation in the signals, the heat flow is obviously different from the growth of the m = 1 magnetic island. Furthermore, it is also shown that the large heat flow or the displacement of the hot core occurs only after the crash. Hence, the large displacement of the hot core is just a result of the crash rather than the cause. The heat flow from both the x points of the m = 2 island is also observed. This observation demonstrates that a purely fast reconnection of the m = 1 magnetic island is not responsible for the crash, but that it may be due to the rapid energy and particle diffusion in the stochastic region.

  14. Study of lower hybrid current drive efficiency and its correlation with photon temperatures in the HT-7 tokamak

    NASA Astrophysics Data System (ADS)

    Younis, J.; Wan, B. N.; Lin, S. Y.; Shi, Y. J.; Ding, B. J.; Gong, X.; HT-7 Team

    2009-07-01

    Lower hybrid current drive (LHCD) efficiency is a very important parameter. The experimental current drive efficiency is defined as η = IrfneR/PLH, where Irf is the current driven by the lower hybrid waves (LHWs), ne is the central line-average density, R is the major radius of the plasma and PLH is the injected LH wave power absorbed by the plasma through Landau damping. A study of current drive efficiency of LHWs in the HT-7 tokamak has been carried out in the parameter ranges: ne = (1.2-2.5) × 1019 m-3, Ip = (80-200) kA, Bt = 1.8 T, PLH = (188-532) kW in the limiter configuration. Current drive efficiency is investigated through a simple correlation with photon temperature and normalized intensity of fast electron bremstrahlung emission, which is, in the first approximation, proportional to the averaged velocity and population of the fast electrons. The plasma current scanning experiment shows that CD efficiency increase is due to the increase in both the photon temperature and the population of the fast electrons generated by LHWs. The density scanning experiment shows that as the plasma density is increased, an increment in CD efficiency along with the increase in the population of fast electrons is observed. The slowing down through the collisions with bulk electrons is mainly responsible for the decreased photon temperature during the plasma density scan. These experiments strongly suggest the dominant role of the population of fast electrons generated by LHCD and the generation of the current carried by fast electrons.

  15. A Hybrid Heating Method for the HT-7U Coils during Vacuum-Pressure Impregnation

    NASA Astrophysics Data System (ADS)

    Cui, Yi-min; Wu, Song-tao; Pan, Wan-jiang; Weng, Pei-de; Wan, Yuan-xi

    2001-04-01

    The HT-7U superconducting tokamak is a full-superconducting magnetically confined fusion device, The toroidal magnet system of HT-7U is a very important part of the device. In VPI (Vacuum-Pressure Impregnation) process the magnet coils must be heated and degassed before impregnating and must be heated to the gel temperature and then the curing temperature, and keep the two kinds of temperatures for a long period of time after impregnating. Thus the heating method of VPI is critical. In this paper, a hybrid method of combining the internal and external heating for the coils is analyzed, especially the possibility of the internal heating method is proved.

  16. Aryl biphenyl-3-ylmethylpiperazines as 5-HT7 receptor antagonists.

    PubMed

    Kim, Jeeyeon; Kim, Youngjae; Tae, Jinsung; Yeom, Miyoung; Moon, Bongjin; Huang, Xi-Ping; Roth, Bryan L; Lee, Kangho; Rhim, Hyewhon; Choo, Il Han; Chong, Youhoon; Keum, Gyochang; Nam, Ghilsoo; Choo, Hyunah

    2013-11-01

    The 5-HT7 receptor (5-HT7 R) is a promising therapeutic target for the treatment of depression and neuropathic pain. The 5-HT7 R antagonist SB-269970 exhibited antidepressant-like activity, whereas systemic administration of the 5-HT7 R agonist AS-19 significantly inhibited mechanical hypersensitivity and thermal hyperalgesia. In our efforts to discover selective 5-HT7 R antagonists or agonists, aryl biphenyl-3-ylmethylpiperazines were designed, synthesized, and biologically evaluated against the 5-HT7 R. Among the synthesized compounds, 1-([2'-methoxy-(1,1'-biphenyl)-3-yl]methyl)-4-(2-methoxyphenyl)piperazine (28) was the best binder to the 5-HT7 R (pKi =7.83), and its antagonistic property was confirmed by functional assays. The selectivity profile of compound 28 was also recorded for the 5-HT7 R over other serotonin receptor subtypes, such as 5-HT1 R, 5-HT2 R, 5-HT3 R, and 5-HT6 R. In a molecular modeling study, the 2-methoxyphenyl moiety attached to the piperazine ring of compound 28 was proposed to be essential for the antagonistic function. PMID:24039134

  17. The 5-HT(7) receptor in learning and memory.

    PubMed

    Roberts, Amanda J; Hedlund, Peter B

    2012-04-01

    The 5-HT(7) receptor is a more recently discovered G-protein-coupled receptor for serotonin. The functions and possible clinical relevance of this receptor are not yet fully understood. The present paper reviews to what extent the use of animal models of learning and memory and other techniques have implicated the 5-HT(7) receptor in such processes. The studies have used a combination of pharmacological and genetic tools targeting the receptor to evaluate effects on behavior and cellular mechanisms. In tests such as the Barnes maze, contextual fear conditioning and novel location recognition that involve spatial learning and memory there is a considerable amount of evidence supporting an involvement of the 5-HT(7) receptor. Supporting evidence has also been obtained in studies of mRNA expression and cellular signaling as well as in electrophysiological experiments. Especially interesting are the subtle but distinct effects observed in hippocampus-dependent models of place learning where impairments have been described in mice lacking the 5-HT(7) receptor or after administration of a selective antagonist. While more work is required, it appears that 5-HT(7) receptors are particularly important in allocentric representation processes. In instrumental learning tasks both procognitive effects and impairments in memory have been observed using pharmacological tools targeting the 5-HT(7) receptor. In conclusion, the use of pharmacological and genetic tools in animal studies of learning and memory suggest a potentially important role for the 5-HT(7) receptor in cognitive processes. PMID:21484935

  18. Comparison of anomalous Doppler resonance effects with molybdenum and graphite limiters on HT-7

    PubMed Central

    Wang, Y. M.; Gao, X.; Ling, B. L.; Liu, Y.; Zhang, S. B.; Han, X.; Ti, A.; Li, E. Z.

    2012-01-01

    The material of limiter in HT-7 tokamak was changed from graphite to molybdenum in the last experimental campaign. The pitch angle scattering of runaway electrons due to anomalous Doppler resonance effects was observed. The experimental results agree very well with the stable boundary condition expected from the linear resistive theory but only agree with that from the nonlinear evolutionary of runaway-electron distribution theory in low electric field region. The current carried by runaway electrons is the same under different limiter conditions. PMID:22509090

  19. The serotonin 5-HT7 receptors: two decades of research.

    PubMed

    Gellynck, Evelien; Heyninck, Karen; Andressen, Kjetil W; Haegeman, Guy; Levy, Finn Olav; Vanhoenacker, Peter; Van Craenenbroeck, Kathleen

    2013-10-01

    Like most neurotransmitters, serotonin possesses a simple structure. However, the pharmacological consequences are more complex and diverse. Serotonin is involved in numerous functions in the human body including the control of appetite, sleep, memory and learning, temperature regulation, mood, behavior, cardiovascular function, muscle contraction, endocrine regulation, and depression. Low levels of serotonin may be associated with several disorders, namely increase in aggressive and angry behaviors, clinical depression, Parkinson's disease, obsessive-compulsive disorder, eating disorders, migraine, irritable bowel syndrome, tinnitus, and bipolar disease. These effects are mediated via different serotonin (5-HT) receptors. In this review, we will focus on the last discovered member of this serotonin receptor family, the 5-HT7 receptor. This receptor belongs to the G protein-coupled receptor superfamily and was cloned two decades ago. Later, different splice variants were described but no major functional differences have been described so far. All 5-HT7 receptor variants are coupled to Gαs proteins and stimulate cAMP formation. Recently, several interacting proteins have been reported, which can influence receptor signaling and trafficking. PMID:24042216

  20. Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7(b))

    PubMed Central

    Jasper, J R; Kosaka, A; To, Z P; Chang, D J; Eglen, R M

    1997-01-01

    The rat 5-hydroxytryptamine (5-HT)7 receptor displays two splice variations, a long form, and a truncated splice isoform, arising from the introduction of a stop codon near the carboxy-terminus. The human 5-HT7 receptor gene contains at least two introns and encodes a 445 amino acid 5-HT receptor. A truncated splice variation in the human 5-HT7 receptor was isolated from a human placental cDNA library. In accordance with current NC-IUPHAR nomenclature guidelines, it is suggested that this receptor be denoted as the h5-HT7(b) receptor and the long form of the receptor as h5-HT7(a). The h5-HT7(b) receptor was stably expressed in HEK 293 cells and ligand affinities were determined by displacement of [3H]-5-carboxyamidotryptamine (5-CT; Kd=0.28±0.06 nM, Bmax=7.3±1.7 pmol mg−1 protein). The rank order of affinities (pKi) for a series of ligands was: 5-carboxamidotryptamine (5-CT, 9.65)>5-hydroxytryptamine (5-HT, 9.41)>methiothepin (8.87)>mesulergine (7.87)>8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT, 6.85)>ketanserin (6.44). The h5-HT7(b) receptor coupled positively to adenylyl cyclase in HEK 293 cells. This response was elicited by a number of agonists with the following order of potency (pEC50): 5-CT (8.7±0.11)>5-MeOT (5-methoxytryptamine; 8.1±0.20)>5-HT (7.5±0.13)>tryptamine (5.6±0.36)>8-OH-DPAT (5.3±0.28)>5-methoxytryptamine (5.0±0.06). This rank order was comparable to that observed in the radioligand binding studies. In a similar fashion to that described for the 5-HT7(a) receptor, PCR studies suggested that the 5-HT7(b) receptor mRNA is found in great abundance throughout the brain, in the small intestine and aorta. It is concluded that the h5-HT7 receptor, like the rat receptor, exists as splice variants exhibiting similar pharmacology, signal transduction and distribution. It is thus likely that there exists a complex physiological role for alternate splicing products of the 5-HT7 receptor gene. PMID:9298538

  1. The human 5-HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects

    PubMed Central

    Krobert, Kurt A; Levy, Finn Olav

    2002-01-01

    Using membranes from stably or transiently transfected HEK293 cells cultured in 5-HT-free medium and expressing the recombinant human 5-HT7 receptor splice variants (h5-HT7(a), h5-HT7(b) and h5-HT7(d)), we compared their abilities to constitutively activate adenylyl cyclase (AC).All h5-HT7 splice variants elevated basal and forskolin-stimulated AC. The basal AC activity was reduced by the 5-HT7 antagonist methiothepin and this effect was blocked by mesulergine (neutral 5-HT7 antagonist) indicating that the inhibitory effect of methiothepin is inverse agonism at the 5-HT7 receptor.Receptor density correlated poorly with constitutive AC activity in stable clonal cell lines and transiently transfected cells. Mean constitutive AC activity as a percentage of forskolin-stimulated AC was significantly higher for the h5-HT7(b) splice variant compared to the h5-HT7(a) and h5-HT7(d) splice variants but only in stable cell lines.All eight 5-HT antagonists tested inhibited constitutive AC activity of all splice variants in a concentration-dependent manner. No differences in inverse agonist potencies (pIC50) were observed between the splice variants. The rank order of potencies was in agreement and highly correlated with antagonist potencies (pKb) determined by antagonism of 5-HT-stimulated AC activity (methiothepin>metergoline>mesulergine⩾clozapine⩾spiperone⩾ritanserin>methysergide>ketanserin).The efficacy of inverse agonism was not receptor level dependent and varied for several 5-HT antagonists between membrane preparations of transiently and stably transfected cells.It is concluded that the h5-HT7 splice variants display similar constitutive activity and inverse agonist properties. PMID:11906971

  2. The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK.

    PubMed

    Lippiello, Pellegrino; Hoxha, Eriola; Speranza, Luisa; Volpicelli, Floriana; Ferraro, Angela; Leopoldo, Marcello; Lacivita, Enza; Perrone-Capano, Carla; Tempia, Filippo; Miniaci, Maria Concetta

    2016-02-01

    The 5-HT7 receptor (5-HT7R) mediates important physiological effects of serotonin, such as memory and emotion, and is emerging as a therapeutic target for the treatment of cognitive disorders and depression. Although previous studies have revealed an expression of 5-HT7R in cerebellum, particularly at Purkinje cells, its functional role and signaling mechanisms have never been described. Using patch-clamp recordings in cerebellar slices of adult mice, we investigated the effects of a selective 5-HT7R agonist, LP-211, on the main plastic site of the cerebellar cortex, the parallel fiber-Purkinje cell synapse. Here we show that 5-HT7R activation induces long-term depression of parallel fiber-Purkinje cell synapse via a postsynaptic mechanism that involves the PKC-MAPK signaling pathway. Moreover, a 5-HT7R antagonist abolished the expression of PF-LTD, produced by pairing parallel fiber stimulation with Purkinje cell depolarization; whereas, application of a 5-HT7R agonist impaired LTP induced by 1 Hz parallel fiber stimulation. Our results indicate for the first time that 5-HT7R exerts a fine regulation of cerebellar bidirectional synaptic plasticity that might be involved in cognitive processes and neuropsychiatric disorders involving the cerebellum. PMID:26482421

  3. The 5-HT7 receptor in learning and memory. Importance of the hippocampus

    PubMed Central

    Roberts, Amanda J.; Hedlund, Peter B.

    2011-01-01

    The 5-HT7 receptor is a more recently discovered G-protein-coupled receptor for serotonin. The functions and possible clinical relevance of this receptor are not yet fully understood. The present paper reviews to what extent the use of animal models of learning and memory and other techniques have implicated the 5-HT7 receptor in such processes. The studies have used a combination of pharmacological and genetic tools targeting the receptor to evaluate effects on behavior and cellular mechanisms. In tests such as the Barnes maze, contextual fear conditioning and novel location recognition that involve spatial learning and memory there is a considerable amount of evidence supporting an involvement of the 5-HT7 receptor. Supporting evidence has also been obtained in studies of mRNA expression and cellular signaling as well as in electrophysiological experiments. Especially interesting are the subtle but distinct effects observed in hippocampus-dependent models of place learning where impairments have been described in mice lacking the 5-HT7 receptor or after administration of a selective antagonist. While more work is required, it appears that 5-HT7 receptors are particularly important in allocentric representation processes. In instrumental learning tasks both procognitive effects and impairments in memory have been observed using pharmacological tools targeting the 5-HT7 receptor. In conclusion, the use of pharmacological and genetic tools in animal studies of learning and memory suggest a potentially important role for the 5-HT7 receptor in cognitive processes. PMID:21484935

  4. Spinal 5-HT7 receptors induce phrenic motor facilitation via EPAC-mTORC1 signaling.

    PubMed

    Fields, D P; Springborn, S R; Mitchell, G S

    2015-09-01

    Spinal serotonin type 7 (5-HT7) receptors elicit complex effects on motor activity. Whereas 5-HT7 receptor activation gives rise to long-lasting phrenic motor facilitation (pMF), it also constrains 5-HT2 receptor-induced pMF via "cross-talk inhibition." We hypothesized that divergent cAMP-dependent signaling pathways give rise to these distinct 5-HT7 receptor actions. Specifically, we hypothesized that protein kinase A (PKA) mediates cross-talk inhibition of 5-HT2 receptor-induced pMF whereas 5-HT7 receptor-induced pMF results from exchange protein activated by cAMP (EPAC) signaling. Anesthetized, paralyzed, and ventilated rats receiving intrathecal (C4) 5-HT7 receptor agonist (AS-19) injections expressed pMF for >90 min, an effect abolished by pretreatment with a selective EPAC inhibitor (ESI-05) but not a selective PKA inhibitor (KT-5720). Furthermore, intrathecal injections of a selective EPAC activator (8-pCPT-2'-Me-cAMP) were sufficient to elicit pMF. Finally, spinal mammalian target of rapamycin complex-1 (mTORC1) inhibition via intrathecal rapamycin abolished 5-HT7 receptor- and EPAC-induced pMF, demonstrating that spinal 5-HT7 receptors elicit pMF by an EPAC-mTORC1 signaling pathway. Thus 5-HT7 receptors elicit and constrain spinal phrenic motor plasticity via distinct signaling mechanisms that diverge at cAMP (EPAC vs. PKA). Selective manipulation of these molecules may enable refined regulation of serotonin-dependent spinal motor plasticity for therapeutic advantage. PMID:26269554

  5. Novel N-acyl-carbazole derivatives as 5-HT7R antagonists.

    PubMed

    Kim, Youngjae; Yeom, Miyoung; Tae, Jinsung; Rhim, Hyewhon; Choo, Hyunah

    2016-03-01

    To discover a novel 5-HT7R antagonist for treatment of depression, we designed N-acyl-carbazole derivatives which were synthesized and biologically evaluated against 5-HT7R. Among total 30 compounds synthesized, four compounds 27-30 showed good binding affinities with Ki values of <100 nM. The compound 28, 1-(9H-carbazol-9-yl)-6-(4-(2-methoxyphenyl)piperazin-1-yl)hexan-1-one, showed good selectivity over other serotonin receptor subtypes and turned out to be a novel selective 5-HT7R antagonist following functional assays. The compound 28 showed moderate activity on hERG channel and good stability in microsomal stability test. The compound 28 exhibited a good pharmacokinetic profile with 67.8% oral bioavailability and good penetration to the brain. The compound 28 was also tested in in vivo depression animal model and showed antidepressant effect in the forced swimming test. Therefore, the selective 5-HT7R antagonist 28 can be considered as a good lead for discovery of novel 5-HT7R antagonists as antidepressants. PMID:26852005

  6. Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.

    PubMed

    Ofori, Edward; Zhu, Xue Y; Etukala, Jagan R; Peprah, Kwakye; Jordan, Kamanski R; Adkins, Adia A; Bricker, Barbara A; Kang, Hye J; Huang, Xi-Ping; Roth, Bryan L; Ablordeppey, Seth Y

    2016-08-15

    5-HT1A and 5-HT7 receptors have been at the center of discussions recently due in part to their major role in the etiology of major central nervous system diseases such as depression, sleep disorders, and schizophrenia. As part of our search to identify dual targeting ligands for these receptors, we have carried out a systematic modification of a selective 5HT7 receptor ligand culminating in the identification of several dual 5-HT1A and 5-HT7 receptor ligands. Compound 16, a butyrophenone derivative of tetrahydroisoquinoline (THIQ), was identified as the most potent agent with low nanomolar binding affinities to both receptors. Interestingly, compound 16 also displayed moderate affinity to other clinically relevant dopamine receptors. Thus, it is anticipated that compound 16 may serve as a lead for further exploitation in our quest to identify new ligands with the potential to treat diseases of CNS origin. PMID:27312422

  7. Evidence for 5-HT7 receptors mediating relaxation of human colonic circular smooth muscle

    PubMed Central

    Prins, Nicolaas H; Briejer, Michel R; Van Bergen, Patrick J E; Akkermans, Louis M A; Schuurkes, Jan A J

    1999-01-01

    5-HT4 receptors mediate relaxation of human colon circular muscle. However, after 5-HT4 receptor blockade (SB 204070 10 nM), 5-HT still induced a relaxation (pEC50 6.3). 5-HT4 receptors were sufficiently blocked, as the curves to 5-HT obtained in the presence of 10 and 100 nM SB 204070 were indistinguishable. This 5-HT-induced relaxation was tetrodotoxin-insensitive, indicative of a smooth muscle relaxant 5-HT receptor. This, and the rank order of potency (5-CT=5-MeOT=5-HT) suggested involvement of 5-HT1 or 5-HT7 receptors. Mesulergine, a 5-HT7 receptor antagonist at nanomolar concentrations, and a 5-HT1 receptor antagonist at micromolar concentrations, competitively antagonized the 5-HT-induced relaxation (pKB 8.3) and antagonized the relaxation to 5-CT. Methysergide antagonized the 5-HT-induced relaxation (pA2 7.6). It is concluded that the profile of the smooth muscle inhibitory 5-HT receptor resembles that of the 5-HT7 receptor. These data provide the first evidence for functional human 5-HT7 receptors. PMID:10556917

  8. Raman calibration of the HT-7 yttrium aluminum garnet Thomson scattering for electron density measurements

    SciTech Connect

    Zang Qing; Zhao Junyu; Gao Xiang; Shi Lingwei; Zhang Tao; Xi Xiaoqi; Yang Li; Hu Qingsheng; Sajjad, S.

    2007-11-15

    A multipulse neodym doped yttrium aluminum garnet laser Thomson scattering system calibrated by the anti-Stokes rotational Raman scattering from nitrogen gas had been developed in the HT-7 superconducting Tokmak. By virtue of this system, measured electron density results of the plasma were obtained. The results showed good repeatability and its total uncertainty was estimated to be {+-}18%.

  9. Spatial memory deficit across aging: current insights of the role of 5-HT7 receptors

    PubMed Central

    Beaudet, Gregory; Bouet, Valentine; Jozet-Alves, Christelle; Schumann-Bard, Pascale; Dauphin, François; Paizanis, Eleni; Boulouard, Michel; Freret, Thomas

    2015-01-01

    Elderly persons often face biological, psychological or social changes over time that may cause discomfort or morbidity. While some cognitive domains remain stable over time, others undergo a decline. Spatial navigation is a complex cognitive function essential for independence, safety and quality of life. While egocentric (body-centered) navigation is quite preserved during aging, allocentric (externally-centered) navigation—based on a cognitive map using distant landmarks—declines with age. Recent preclinical studies showed that serotonergic 5-HT7 receptors are localized in brain regions associated with allocentric spatial navigation processing. Behavioral assessments with pharmacological or genetic tools have confirmed the role of 5-HT7 receptors in allocentric navigation. Moreover, few data suggested a selective age-related decrease in the expression of 5-HT7 receptors in pivotal brain structures implicated in allocentric navigation such as the hippocampal CA3 region. We aim to provide a short overview of the potential role of 5-HT7 receptors in spatial navigation, and to argue for their interests as therapeutic targets against age-related cognitive decline. PMID:25642173

  10. 5-HT7 receptor activation promotes an increase in TrkB receptor expression and phosphorylation

    PubMed Central

    Samarajeewa, Anshula; Goldemann, Lolita; Vasefi, Maryam S.; Ahmed, Nawaz; Gondora, Nyasha; Khanderia, Chandni; Mielke, John G.; Beazely, Michael A.

    2014-01-01

    The serotonin (5-HT) type 7 receptor is expressed throughout the CNS including the cortex and hippocampus. We have previously demonstrated that the application of 5-HT7 receptor agonists to primary hippocampal neurons and SH-SY5Y cells increases platelet-derived growth factor (PDGF) receptor expression and promotes neuroprotection against N-methyl-D-aspartate-(NMDA)-induced toxicity. The tropomyosin-related kinase B (TrkB) receptor is one of the receptors for brain-derived neurotrophic factor (BDNF) and is associated with neurodevelopmental and neuroprotective effects. Application of LP 12 to primary cerebral cortical cultures, SH-SY5Y cells, as well as the retinal ganglion cell line, RGC-5, increased both the expression of full length TrkB as well as its basal phosphorylation state at tyrosine 816. The increase in TrkB expression and phosphorylation was observed as early as 30 min after 5-HT7 receptor activation. In addition to full-length TrkB, kinase domain-deficient forms may be expressed and act as dominant-negative proteins toward the full length receptor. We have identified distinct patterns of TrkB isoform expression across our cell lines and cortical cultures. Although TrkB receptor expression is regulated by cyclic AMP and Gαs-coupled GPCRs in several systems, we demonstrate that, depending on the model system, pathways downstream of both Gαs and Gα12 are involved in the regulation of TrkB expression by 5-HT7 receptors. Given the number of psychiatric and degenerative diseases associated with TrkB/BDNF deficiency and the current interest in developing 5-HT7 receptor ligands as pharmaceuticals, identifying signaling relationships between these two receptors will aid in our understanding of the potential therapeutic effects of 5-HT7 receptor ligands. PMID:25426041

  11. Targeting the Serotonin 5-HT7 Receptor in the Search for Treatments for CNS Disorders: Rationale and Progress to Date.

    PubMed

    Nikiforuk, Agnieszka

    2015-04-01

    The 5-HT7 (5-hydroxytryptamine 7, serotonin 7) receptor is one of the most recently identified members of the serotonin receptor family. Pharmacological tools, including selective antagonists and, more recently, agonists, along with 5-HT7 receptor (5-HT7R) knock-out mice have revealed the involvement of this receptor in central nervous system processes. Its well-established role in controlling body temperature and regulating sleep and circadian rhythms has implicated this receptor in mood disorders. Thus, the 5-HT7R has gained much attention as a possible target for the treatment of depression. Although preclinical data support the antidepressant-like actions of 5-HT7R antagonists, their clinical efficacy has not been yet established. Other evidence has implicated the 5-HT7R in learning and memory. Preclinical findings suggest that blockade of this receptor may be beneficial against schizophrenia-like cognitive deficits. Other possible indications include nociception, epilepsy, migraine, autism spectrum disorders, and Rett Syndrome. However, the question is whether the beneficial effects may be achieved by activation or blockade of 5-HT7Rs. Hence, this review briefly summarises the recent findings on the role of 5-HT7Rs and their ligands in CNS disorders. PMID:25721336

  12. Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist

    PubMed Central

    Hagan, Jim J; Price, Gary W; Jeffrey, Phillip; Deeks, Nigel J; Stean, Tania; Piper, David; Smith, Martin I; Upton, Neil; Medhurst, Andrew D; Middlemiss, Derek N; Riley, Graham J; Lovell, Peter J; Bromidge, Steven M; Thomas, David R

    2000-01-01

    The novel 5-HT7 receptor antagonist, SB-269970-A, potently displaced [3H]-5-CT from human 5-HT7(a) (pKi 8.9±0.1) and 5-HT7 receptors in guinea-pig cortex (pKi 8.3±0.2).5-CT stimulated adenylyl cyclase activity in 5-HT7(a)/HEK293 membranes (pEC50 7.5±0.1) and SB-269970-A (0.03–1 μM) inhibited the 5-CT concentration-response with no significant alteration in the maximal response. The pA2 (8.5±0.2) for SB-269970-A agreed well with the pKi determined from [3H]-5-CT binding studies.5-CT-stimulated adenylyl cyclase activity in guinea-pig hippocampal membranes (pEC50 of 8.4±0.2) was inhibited by SB-269970-A (0.3 μM) with a pKB (8.3±0.1) in good agreement with its antagonist potency at the human cloned 5-HT7(a) receptor and its binding affinity at guinea-pig cortical membranes.5-HT7 receptor mRNA was highly expressed in human hypothalamus, amygdala, thalamus, hippocampus and testis.SB-269970-A was CNS penetrant (steady-state brain : blood ratio of ca. 0.83 : 1 in rats) but was rapidly cleared from the blood (CLb=ca. 140 ml min−1 kg−1). Following a single dose (3 mg kg−1) SB-269970 was detectable in rat brain at 30 (87 nM) and 60 min (58 nM). In guinea-pigs, brain levels averaged 31 and 51 nM respectively at 30 and 60 min after dosing, although the compound was undetectable in one of the three animals tested.5-CT (0.3 mg kg−1 i.p.) induced hypothermia in guinea-pigs was blocked by SB-269970-A (ED50 2.96 mg kg−1 i.p.) and the non-selective 5-HT7 receptor antagonist metergoline (0.3–3 mg kg−1 s.c.), suggesting a role for 5-HT7 receptor stimulation in 5-CT induced hypothermia in guinea-pigs.SB-269970-A (30 mg kg−1) administered at the start of the sleep period, significantly reduced time spent in Paradoxical Sleep (PS) during the first 3  h of EEG recording in conscious rats. PMID:10821781

  13. Characterization and distribution of putative 5-ht7 receptors in guinea-pig brain.

    PubMed Central

    To, Z. P.; Bonhaus, D. W.; Eglen, R. M.; Jakeman, L. B.

    1995-01-01

    1. In the presence of (-)-cyanopindolol (1.0 microM) and sumatriptan (1.0 microM), 0.5 nM [3H]-carboxamidotrytamine ([3H]-5-CT) labelled a single population of receptors in guinea-pig cerebral cortex membranes. 2. 5-HT-displaceable binding was rapid, saturable and reversible. A high affinity binding site was characterized both by equilibrium saturation (Kd = 0.76 +/- 0.28 nM; Bmax = 68.1 +/- 26.7 fmol mg-1 protein) and kinetic (Kd = 0.18 +/- 0.05 nM) analysis. The pharmacological profile of this site was similar to the profile obtained in transfected CHO-K1 cells expressing guinea-pig 5-ht7 receptors. 3. Autoradiographic analysis revealed a discrete localization of binding sites in guinea-pig brain, with the highest density of sites in the medial thalamic nuclei and related limbic and cortical regions. Moderate levels of binding were detected in sensory relay nuclei, substantia nigra, hypothalamus, central grey and dorsal raphe nuclei. This distribution corresponded to that observed using in situ hybridization with [35S]-UTP labelled riboprobes complementary to mRNA encoding the guinea-pig 5-ht7 receptor. 4. In conclusion, under appropriate conditions, [3H]-5-CT labelled a single population of saturable binding sites that corresponded to an endogenous 5-ht7 receptor in guinea-pig brain. The distribution of 5-ht7 receptors in thalamocortical and limbic brain regions suggests a role for these receptors in sensory and affective behaviours. Images Figure 5 Figure 6 PMID:7647964

  14. 5-HT7 receptor modulates GABAergic transmission in the rat dorsal raphe nucleus and controls cortical release of serotonin

    PubMed Central

    Kusek, Magdalena; Sowa, Joanna; Kamińska, Katarzyna; Gołembiowska, Krystyna; Tokarski, Krzysztof; Hess, Grzegorz

    2015-01-01

    The 5-HT7 receptor is one of the several serotonin (5-HT) receptor subtypes that are expressed in the dorsal raphe nucleus (DRN). Some earlier findings suggested that 5-HT7 receptors in the DRN were localized on GABAergic interneurons modulating the activity of 5-HT projection neurons. The aim of the present study was to find out how the 5-HT7 receptor modulates the GABAergic synaptic input to putative 5-HT DRN neurons, and whether blockade of the 5-HT7 receptor would affect the release of 5-HT in the target structure. Male Wistar rats with microdialysis probes implanted in the prefrontal cortex (PFC) received injections of the 5-HT7 receptor antagonist (2R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride (SB 269970), which induced an increase in the levels of 5-HT and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA) in the PFC. In another set of experiments whole-cell recordings from presumed projection neurons were carried out using DRN slices. SB 269970 application resulted in depolarization and in an increase in the firing frequency of the cells. In order to activate 5-HT7 receptors, 5-carboxamidotryptamine (5-CT) was applied in the presence of N-[2-[4-(2-methoxyphenyl)-1piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide (WAY100635). Hyperpolarization of cells and a decrease in the firing frequency were observed after activation of the 5-HT7 receptor. Blockade of 5-HT7 receptors caused a decrease in the mean frequency of spontaneous inhibitory postsynaptic currents (sIPSCs), while its activation induced an increase. The mechanism of these effects appears to involve tonically-active 5-HT7 receptors modulating firing and/or GABA release from inhibitory interneurons which regulate the activity of DRN serotonergic projection neurons. PMID:26347612

  15. Am5-HT7: molecular and pharmacological characterization of the first serotonin receptor of the honeybee (Apis mellifera).

    PubMed

    Schlenstedt, Jana; Balfanz, Sabine; Baumann, Arnd; Blenau, Wolfgang

    2006-09-01

    The biogenic amine serotonin (5-HT) plays a key role in the regulation and modulation of many physiological and behavioural processes in both vertebrates and invertebrates. These functions are mediated through the binding of serotonin to its receptors, of which 13 subtypes have been characterized in vertebrates. We have isolated a cDNA from the honeybee Apis mellifera (Am5-ht7) sharing high similarity to members of the 5-HT(7) receptor family. Expression of the Am5-HT(7) receptor in HEK293 cells results in an increase in basal cAMP levels, suggesting that Am5-HT(7) is expressed as a constitutively active receptor. Serotonin application to Am5-ht7-transfected cells elevates cyclic adenosine 3',5'-monophosphate (cAMP) levels in a dose-dependent manner (EC(50) = 1.1-1.8 nm). The Am5-HT(7) receptor is also activated by 5-carboxamidotryptamine, whereas methiothepin acts as an inverse agonist. Receptor expression has been investigated by RT-PCR, in situ hybridization, and western blotting experiments. Receptor mRNA is expressed in the perikarya of various brain neuropils, including intrinsic mushroom body neurons, and in peripheral organs. This study marks the first comprehensive characterization of a serotonin receptor in the honeybee and should facilitate further analysis of the role(s) of the receptor in mediating the various central and peripheral effects of 5-HT. PMID:16945110

  16. The 5-HT7 receptor as a potential target for treating drug and alcohol abuse

    PubMed Central

    Hauser, Sheketha R.; Hedlund, Peter B.; Roberts, Amanda J.; Sari, Youssef; Bell, Richard L.; Engleman, Eric A.

    2015-01-01

    Alcohol and drug abuse take a large toll on society and affected individuals. However, very few effective treatments are currently available to treat alcohol and drug addiction. Basic and clinical research has begun to provide some insights into the underlying neurobiological systems involved in the addiction process. Several neurotransmitter pathways have been implicated and distinct reward neurocircuitry have been proposed—including the mesocorticolimbic dopamine (MCL-DA) system and the extended amygdala. The serotonin (5-HT) neurotransmitter system is of particular interest and multiple 5-HT receptors are thought to play significant roles in alcohol and drug self-administration and the development of drug dependence. Among the 5-HT receptors, the 5-HT7 receptor is currently undergoing characterization as a potential target for the treatment of several psychiatric disorders. Although this receptor has received only limited research regarding addictive behaviors, aspects of its neuroanatomical, biochemical, physiological, pharmacological, and behavioral profiles suggest that it could play a key role in the addiction process. For instance, genomic studies in humans have suggested a link between variants in the gene encoding the 5-HT7 receptor and alcoholism. Recent behavioral testing using high-affinity antagonists in mice and preliminary tests with alcohol-preferring rats suggest that this receptor could mediate alcohol consumption and/or reinforcement and play a role in seeking/craving behavior. Interest in the development of new and more selective pharmacological agents for this receptor will aid in examining the 5-HT7 receptor as a novel target for treating addiction. PMID:25628528

  17. The 5-HT7 receptor as a potential target for treating drug and alcohol abuse.

    PubMed

    Hauser, Sheketha R; Hedlund, Peter B; Roberts, Amanda J; Sari, Youssef; Bell, Richard L; Engleman, Eric A

    2014-01-01

    Alcohol and drug abuse take a large toll on society and affected individuals. However, very few effective treatments are currently available to treat alcohol and drug addiction. Basic and clinical research has begun to provide some insights into the underlying neurobiological systems involved in the addiction process. Several neurotransmitter pathways have been implicated and distinct reward neurocircuitry have been proposed-including the mesocorticolimbic dopamine (MCL-DA) system and the extended amygdala. The serotonin (5-HT) neurotransmitter system is of particular interest and multiple 5-HT receptors are thought to play significant roles in alcohol and drug self-administration and the development of drug dependence. Among the 5-HT receptors, the 5-HT7 receptor is currently undergoing characterization as a potential target for the treatment of several psychiatric disorders. Although this receptor has received only limited research regarding addictive behaviors, aspects of its neuroanatomical, biochemical, physiological, pharmacological, and behavioral profiles suggest that it could play a key role in the addiction process. For instance, genomic studies in humans have suggested a link between variants in the gene encoding the 5-HT7 receptor and alcoholism. Recent behavioral testing using high-affinity antagonists in mice and preliminary tests with alcohol-preferring rats suggest that this receptor could mediate alcohol consumption and/or reinforcement and play a role in seeking/craving behavior. Interest in the development of new and more selective pharmacological agents for this receptor will aid in examining the 5-HT7 receptor as a novel target for treating addiction. PMID:25628528

  18. Surface analysis of VPS-W coatings boronized by an ICRF discharge in HT-7

    NASA Astrophysics Data System (ADS)

    Yang, Zhongshi; Wang, Wanjing; Li, Qiang; Wu, Jing; Okuno, Kenji; Oya, Yasuhisa; Luo, Guang-Nan

    2011-10-01

    To understand the surface compositions and the hydrogen isotope behavior in boronized Vacuum plasma spraying (VPS)-W, the boron coating has been achieved by means of Ion Cyclotron Radio Frequency (ICRF) boronization using carborane (C 2B 10H 12) powder as the precursor material in HT-7. Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) were used to observe the morphology of the VPS-W and boronized W surfaces. The X-ray Photoelectron Spectroscopy (XPS) of W-4f, O-1s, C-1s and B-1s on the VPS-W sample before and after boronization and after plasma exposure have been measured. The B-B and B-C bonds were observed after boronization treatment for VPS-W. Thermal Desorption Spectroscopy (TDS) experiments were also carried out to investigate the thermal desorption behavior of D implanted into the samples. After HT-7 plasma exposure, the desorption spectrum had a low temperature peak associated with trapping in intrinsic defects in polycrystalline W and a high temperature peak associated with B-O-D and B-C-D bonds.

  19. Investigations of lower hybrid wave-plasma coupling by gas puffing in HT-7

    SciTech Connect

    Ding, B. J.; Li, M. H.; Qin, Y. L.; Li, W. K.; Zhang, L. Z.; Shan, J. F.; Liu, F. K.; Wang, M.; Meng, L. G.; Xu, H. D.; Wang, D. X.; Jie, Y. X.; Sun, Y. W.; Shen, B.; Zhang, W.; Wang, X. M.; Wu, J. H.; Gao, X.; Zhang, X. D.; Zhao, Y. P.

    2010-02-15

    Lower hybrid wave (LHW)-plasma coupling experiments in HT-7 [J. K. Xie and HT-7 Group, Proceedings of the 16th International Conference on Fusion Energy, Montreal, 1996 (IAEA, Trieste, 1997), Vol. 1, p. 685] were carried out by means of puffing gas (CD{sub 4} and D{sub 2}) just around the antenna. Both experiments show that wave-plasma coupling is improved by the gas puffing. The maximum distance between the plasma and the antenna is limited to about 8 cm due to the plasma disruption. The variation in the lined averaged density in the different channels gives a possible evidence of the mechanism of the ionization of neutral gas. The effect of the gas flow rate on the wave-plasma coupling shows that an optimized gas flow rate is necessary for good coupling, being consistent with simulation through Brambilla theory qualitatively. Experiments with puffing D{sub 2} show that the improved coupling results from the global density increase and the local gas puffing. Langmuir probe measurements indicate that the gas puffing effectively increases the density and decreases the temperature in scrape of layer. Studies show that the ionization of the puffed gas is affected by both LHW electric field and plasma temperature. Comparison of D{sub 2} and CD{sub 4} puffing shows that D{sub 2} improves coupling better with less effect on core density.

  20. The critical role of spinal 5-HT7 receptors in opioid and non-opioid type stress-induced analgesia.

    PubMed

    Yesilyurt, Ozgur; Seyrek, Melik; Tasdemir, Serdar; Kahraman, Serdar; Deveci, Mehmet Salih; Karakus, Emre; Halici, Zekai; Dogrul, Ahmet

    2015-09-01

    The opioid and non-opioid types of stress-induced analgesia have been well defined. One of the non-opioid type involve the endocannabinoid system. We previously reported that the spinal serotonin 7 receptor (5-HT7) blockers inhibit both morphine and cannabinoid-induced analgesia, thus we hypothesized that descending serotonergic pathways-spinal 5-HT7 receptor loop might contribute to stress-induced analgesia. Stress-induced analgesia was induced with warm (32°C) or cold (20°C) water swim stress in male Balb-C mice. The effects of intrathecal injection of a selective 5-HT7 receptor antagonist, SB 269970, of the denervation of serotonergic neurons by intrathecal administration of 5,7-dihydroxytryptamine (5,7-DHT) and of lesions of the dorsolateral funiculus on opioid and non-opioid type stress-induced analgesia were evaluated with the tail-flick and hot plate tests. The expression of 5-HT7 receptors mRNA in the dorsal lumbar region of spinal cord were analyzed by RT-PCR following spinal serotonin depletion or dorsolateral funiculus lesion. The effects of the selective 5-HT7 receptor agonists LP 44 and AS 19 were tested on nociception. Intrathecal SB 269970 blocked both opioid and non-opioid type stress-induced analgesia. Dorsolateral funiculus lesion or denervation of the spinal serotonergic neurons resulted in a marked decrease in 5-HT7 receptor expression in the dorsal lumbar spinal cord, accompanied by inhibition of opioid and non-opioid type stress-induced analgesia. However, the systemic or intrathecal LP 44 and AS 19 alone did not produce analgesia in unstressed mice. These results indicate that descending serotonergic pathways and the spinal 5-HT7 receptor loop play a crucial role in mediating both opioid and non-opioid type stress-induced analgesia. PMID:25917322

  1. 5-HT7 Receptors Are Not Involved in Neuropeptide Release in Primary Cultured Rat Trigeminal Ganglion Neurons.

    PubMed

    Wang, Xiaojuan; Hu, Rong; Liang, Jianbo; Li, Ze; Sun, Weiwen; Pan, Xiaoping

    2016-06-01

    Migraine is a common but complex neurological disorder. Its precise mechanisms are not fully understood. Increasing indirect evidence indicates that 5-HT7 receptors may be involved; however, their role remains unknown. Our previous in vivo study showed that selective blockade of 5-HT7 receptors caused decreased serum levels of calcitonin gene-related peptide (CGRP) in the external jugular vein following electrical stimulation of the trigeminal ganglion (TG) in an animal model of migraine. In the present study, we used an in vitro model of cultured TG cells to further investigate whether 5-HT7 receptors are directly responsible for the release of CGRP and substance P from TG neurons. We stimulated rat primary cultured TG neurons with capsaicin or potassium chloride (KCl) to mimic neurogenic inflammation, resulting in release of CGRP and substance P. 5-HT7 receptors were abundantly expressed in TG neurons. Greater than 93 % of 5-HT7 receptor-positive neurons co-expressed CGRP and 56 % co-expressed substance P. Both the capsaicin- and KCl-induced release of CGRP and substance P were unaffected by pretreatment of cultured TG cells with the selective 5-HT7 receptor agonist AS19 and antagonist SB269970. This study demonstrates for the first time that 5-HT7 receptors are abundantly co-expressed with CGRP and substance P in rat primary TG neurons and suggests that they are not responsible for the release of CGRP and substance P from cultured TG neurons evoked by capsaicin or KCl. PMID:26892478

  2. Characterization of putative 5-HT7 receptors mediating tachycardia in the cat

    PubMed Central

    Villalón, Carlos M; Heiligers, Jan P C; Centurión, David; De Vries, Peter; Saxena, Pramod R

    1997-01-01

    , sumatriptan (30, 100 and 300 μg kg−1) and indorenate (300 and 1000 μg kg−1) or the 5-HT4 receptor (partial) agonist cisapride (300 and 1000 μg kg−1) were devoid of effects on feline heart rate per se and failed to modify significantly 5-HT-induced tachycardic responses. Based upon the above rank order of agonist potency, the failure of sumatriptan, indorenate or cisapride to produce cardioacceleration and the blockade by a series of drugs showing high affinity for the cloned 5-ht7 receptor, the present results indicate that the 5-HT receptor mediating tachycardia in the cat is operationally similar to other putative 5-HT7 receptors mediating vascular and non-vascular responses (e.g. relaxation of the rabbit femoral vein, canine external carotid and coronary arteries, rat systemic vasculature and guinea-pig ileum). Since these responses represent functional correlates of the 5-ht7 gene product, the 5-HT7 receptor appellation is reinforced. Therefore, the present experimental model, which is not complicated by the presence of other 5-HT receptors, can be utilized to characterize and develop new drugs with potential agonist and antagonist properties at functional 5-HT7 receptors. PMID:9249256

  3. Expression of the spinal 5-HT7 receptor and p-ERK pathway in the carrageenan inflammatory pain of rats

    PubMed Central

    Cho, Soo Young; Ki, Hyoung Gon; Kim, Joung Min; Oh, Jin Myung; Yang, Ji Hoon; Kim, Woong Mo; Lee, Hyung Gon; Yoon, Myung Ha

    2015-01-01

    Background Although the inhibitory role of the 5-hydroxytrypatmine receptor 7(5-HT7R) on nociceptive processing is generally recognized, an excitatory effect associated with a reduced 5-HT7R expression has also been observed in the nerve injury model. In the carrageenan model, no significant effect is produced by the 5-HT7R activation, but the change in 5-HT7R expression has not been examined. Lesioning of the spinal serotonergic pathway enhances allodynia in the carrageenan model, but it also relieves several other pain states, including in the formalin model. While lesioning suppresses the activation of the extracellular signal-regulated kinase (ERK) of the spinal cord in the formalin model, its role in the carrageenan model has not been reported. Methods Following intraplantar injections of carrageenan, the spinal 5-HT7R expression was examined using Western blotting in male Sprague-Dawley rats. The effect of serotonergic pathway lesioning with intrathecal 5,7-dihydroxytryptamine (5,7-DHT) on the expression of the phospho-ERK was measured. Results The expression of the 5-HT7R in the carrageenan model was not significantly different from that of naive animals. The expression of the spinal p-ERK in the carrageenan model was significantly increased, but returned to the level of a naive rat 1 hour after the carrageenan injection. However, it remained significantly higher 1 hour after the injection in the animals treated with 5,7-DHT than in the naive and control rats. Conclusions The expression of the spinal 5-HT7R is not altered by peripheral inflammation with carrageenan, suggesting that the lack of antinociceptive effect of the 5-HT7R activation is partly attributable to the absence of changes in the expression of the 5-HT7R in the spinal cord. The extended increase of the spinal p-ERK might be related to the enhanced pain behavior in the animals with lesions of the spinal serotonergic pathway in the carrageenan model. PMID:25844136

  4. Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives.

    PubMed

    Matthys, Anne; Haegeman, Guy; Van Craenenbroeck, Kathleen; Vanhoenacker, Peter

    2011-06-01

    Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT)7 receptor in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS). Some data obtained with 5-HT7 receptor knockout mice, selective antagonists, and, to a lesser extent, agonists, however, are quite contradictory. In this review, we not only discuss in detail the role of the 5-HT7 receptor in the CNS but also propose some hypothetical models, which could explain the observed inconsistencies. These models are based on two novel concepts within the field of G protein-coupled receptors (GPCR), namely biphasic signaling and G protein-independent signaling, which both have been shown to be mediated by GPCR dimerization. This led us to suggest that the 5-HT7 receptor could reside in different dimeric contexts and initiate different signaling pathways, depending on the neuronal circuitry and/or brain region. In conclusion, we highlight GPCR dimerization and G protein-independent signaling as two promising future directions in 5-HT7 receptor research, which ultimately might lead to the development of more efficient dimer- and/or pathway-specific therapeutics. PMID:21424680

  5. Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders

    PubMed Central

    Leopoldo, Marcello; Lacivita, Enza; Berardi, Francesco; Perrone, Roberto; Hedlund, Peter B.

    2010-01-01

    Since its discovery in the 1940s in serum, the mammalian intestinal mucosa, and in the central nervous system, serotonin (5-HT) has been shown to be involved in virtually all cognitive and behavioral human functions, and alterations in its neurochemistry have been implicated in the etiology of a plethora of neuropsychiatric disorders. The cloning of 5-HT receptor subtypes has been of importance in enabling them to be classified as specific protein molecules encoded by specific genes. The 5-HT7 receptor is the most recently classified member of the serotonin receptor family. Since its identification, it has been the subject of intense research efforts driven by its presence in functionally relevant regions of the brain. The availability of some selective antagonists and agonists, in combination with genetically modified mice lacking the 5-HT7 receptor, has allowed for a better understanding of the pathophysiological role of this receptor. This paper reviews data on localization and pharmacological properties of the 5-HT7 receptor, and summarizes the results of structure-activity relationship studies aimed at the discovery of selective 5-HT7 receptor ligands. Additionally, an overview of the potential therapeutic applications of 5-HT7 receptor agonists and antagonists in central nervous system disorders is presented. PMID:20923682

  6. Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation.

    PubMed

    Kucwaj-Brysz, Katarzyna; Warszycki, Dawid; Podlewska, Sabina; Witek, Jagna; Witek, Karolina; González Izquierdo, Andrea; Satała, Grzegorz; Loza, María I; Lubelska, Annamaria; Latacz, Gniewomir; Bojarski, Andrzej J; Castro, Marián; Kieć-Kononowicz, Katarzyna; Handzlik, Jadwiga

    2016-04-13

    A series of novel arylpiperazine 5-(4-fluorophenyl)-5-methylhydantoins with 2-hydroxypropyl linker (2-15) was synthesized and evaluated on their affinity towards serotonin 5-HT7 receptor (5-HT7R) in comparison to other closely related GPCRs: serotonin 5-HT1A, and dopamine D2 receptors. The functional activity studied through the measurement of 5-HT7R-mediated cyclic AMP production in Human Embryonic Kidney 293 cells (HEK293) stably expressing human 5-HT7 proved their antagonistic properties. The lead structure was also examined in the preliminary metabolic stability study using human liver microsomes (HMLs). The process of selection of candidates for synthesis was supported by a special molecular modeling workflow including combinatorial library generation, docking, and machine learning-based assessment. Additionally, in silico predictions of selectivity over 5-HT1AR and D2R, as well as functional activity were carried out. The newly synthesized compounds were proved to possess a potent affinity for 5-HT7R, similar to that of the lead structure of 5-(4-fluorophenyl)-3-(3-(4-(2-methoxyphenyl)piperazin-1-yl)-2-hydroxypropyl)-5-methylimidazolidine-2,4-dione (1). For several derivatives, significant selectivity both over 5-HT1AR and D2R was found. PMID:26900658

  7. The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.

    PubMed

    Medina, Rocío A; Vázquez-Villa, Henar; Gómez-Tamayo, José C; Benhamú, Bellinda; Martín-Fontecha, Mar; de la Fuente, Tania; Caltabiano, Gianluigi; Hedlund, Peter B; Pardo, Leonardo; López-Rodríguez, María L

    2014-08-14

    The finding that ergotamine binds serotonin receptors in a less conserved extended binding pocket close to the extracellular entrance, in addition to the orthosteric site, allowed us to obtain 5-HT7R antagonist 6 endowed with high affinity (Ki=0.7 nM) and significant 5-HT1AR selectivity (ratio>1428). Compound 6 exhibits in vivo antidepressant-like effect (1 mg/kg, ip) mediated by the 5-HT7R, which reveals its interest as a putative research tool or pharmaceutical in depression disorders. PMID:25073094

  8. Stimulation of 5-HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas.

    PubMed

    Nativio, Paola; Zoratto, Francesca; Romano, Emilia; Lacivita, Enza; Leopoldo, Marcello; Pascale, Esterina; Passarelli, Francesca; Laviola, Giovanni; Adriani, Walter

    2015-11-01

    Brain serotonin 7 (5-HT7) receptors play an important functional role in learning and memory, in regulation of mood and motivation, and for circadian rhythms. Recently, we have studied the modulatory effects of a developmental exposure (under subchronic regimen) in rats with LP-211, a brain-penetrant and selective 5-HT7 receptor agonist. We aimed at further deciphering long-term sequelae into adulthood. LP-211 (0.250 mg/kg i.p., once/day) was administered for 5 days during the adolescent phase (postnatal days 43-45 to 47-49). When adult (postnatal days >70), forebrain areas were obtained for ex vivo immunohistochemistry, whose results prompted us to reconsider the brain connectivity maps presented in our previous study (Canese et al., Psycho-Pharmacol 2015;232:75-89.) Significant elevation in levels of 5-HT7 receptors were evidenced due to adolescent LP-211 exposure, in dorsal striatum (which also shows an increase of dopaminergic D2 auto-receptors) and-unexpectedly-in piriform cortex, with no changes in ventral striatum. We observed that functional connectivity from a seed on the right hippocampus was more extended than reported, also including the piriform cortex. As a whole, the cortical loop rearranged by adolescent LP-211 exposure consisted in a hippocampus receiving connections from piriform cortex and dorsal striatum, the latter both directly and through functional control over the 'extended amygdala'. Such results represent a starting point to explore neurophysiology of 5-HT7 receptors. Further investigation is warranted to develop therapies for sleep disorders, for impaired emotional and motivational regulation, for attentive and executive deficit. The 5-HT7 agonist LP-211 (0.250 mg/kg i.p., once/day) was administered for 5 days during adolescence (postnatal days 43-45 to 47-49) in rats. When adult (postnatal days >70), a significant elevation in levels of 5-HT7 receptors were evidenced in dorsal striatum and-unexpectedly-in piriform cortex. PMID:26364910

  9. The Type 7 Serotonin Receptor, 5-HT7, Is Essential in the Mammary Gland for Regulation of Mammary Epithelial Structure and Function

    PubMed Central

    Pai, Vaibhav P.; Hernandez, Laura L.; Stull, Malinda A.; Horseman, Nelson D.

    2015-01-01

    Autocrine-paracrine activity of serotonin (5-hydroxytryptamine, 5-HT) is a crucial homeostatic parameter in mammary gland development during lactation and involution. Published studies suggested that the 5-HT7 receptor type was important for mediating several effects of 5-HT in the mammary epithelium. Here, using 5-HT7 receptor-null (HT7KO) mice we attempt to understand the role of this receptor in mediating 5-HT actions within the mammary gland. We demonstrate for the first time that HT7KO dams are inefficient at sustaining their pups. Histologically, the HT7KO mammary epithelium shows a significant deviation from the normal secretory epithelium in morphological architecture, reduced secretory vesicles, and numerous multinucleated epithelial cells with atypically displaced nuclei, during lactation. Mammary epithelial cells in HT7KO dams also display an inability to transition from lactation to involution as normally seen by transition from a columnar to a squamous cell configuration, along with alveolar cell apoptosis and cell shedding. Our results show that 5-HT7 is required for multiple actions of 5-HT in the mammary glands including core functions that contribute to changes in cell shape and cell turnover, as well as specialized secretory functions. Understanding these actions may provide new interventions to improve lactation performance and treat diseases such as mastitis and breast cancer. PMID:25664318

  10. 5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders

    PubMed Central

    Ciranna, Lucia; Catania, Maria Vincenza

    2014-01-01

    Serotonin type 7 receptors (5-HT7) are expressed in several brain areas, regulate brain development, synaptic transmission and plasticity, and therefore are involved in various brain functions such as learning and memory. A number of studies suggest that 5-HT7 receptors could be potential pharmacotherapeutic target for cognitive disorders. Several abnormalities of serotonergic system have been described in patients with autism spectrum disorder (ASD), including abnormal activity of 5-HT transporter, altered blood and brain 5-HT levels, reduced 5-HT synthesis and altered expression of 5-HT receptors in the brain. A specific role for 5-HT7 receptors in ASD has not yet been demonstrated but some evidence implicates their possible involvement. We have recently shown that 5-HT7 receptor activation rescues hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome, a monogenic cause of autism. Several other studies have shown that 5-HT7 receptors modulate behavioral flexibility, exploratory behavior, mood disorders and epilepsy, which include core and co-morbid symptoms of ASD. These findings further suggest an involvement of 5-HT7 receptors in ASD. Here, we review the physiological roles of 5-HT7 receptors and their implications in Fragile X Syndrome and other ASD. PMID:25221471

  11. Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1.

    PubMed

    Manfra, Ornella; Van Craenenbroeck, Kathleen; Skieterska, Kamila; Frimurer, Thomas; Schwartz, Thue W; Levy, Finn Olav; Andressen, Kjetil Wessel

    2015-07-15

    The human 5-HT7 serotonin receptor, a G-protein-coupled receptor (GPCR), activates adenylyl cyclase constitutively and upon agonist activation. Biased ligands differentially activate 5-HT7 serotonin receptor desensitization, internalization and degradation in addition to G protein activation. We have previously found that the atypical antipsychotics clozapine and olanzapine inhibited G protein activation and, surprisingly, induced both internalization and lysosomal degradation of 5-HT7 receptors. Here, we aimed to determine the mechanism of clozapine- and olanzapine-mediated degradation of 5-HT7 receptors. In the C-terminus of the 5-HT7 receptor, we identified two YXXΦ motifs, LR residues, and a palmitoylated cysteine anchor as potential sites involved in receptor trafficking to lysosomes followed by receptor degradation. Mutating either of these sites inhibited clozapine- and olanzapine-mediated degradation of 5-HT7 receptors and also interfered with G protein activation. In addition, we tested whether receptor degradation was mediated by the GPCR-associated sorting protein-1 (GASP-1). We show that GASP-1 binds the 5-HT7 receptor and regulates the clozapine-mediated degradation. Mutations of the identified motifs and residues, located in or close to Helix-VIII of the 5-HT7 receptor, modified antipsychotic-stimulated binding of proteins (such as GASP-1), possibly by altering the flexibility of Helix-VIII, and also interfered with G protein activation. Taken together, our data demonstrate that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1. PMID:25706089

  12. Towards novel 5-HT7versus 5-HT1A receptor ligands among LCAPs with cyclic amino acid amide fragments: design, synthesis, and antidepressant properties. Part II.

    PubMed

    Canale, Vittorio; Kurczab, Rafał; Partyka, Anna; Satała, Grzegorz; Witek, Jagna; Jastrzębska-Więsek, Magdalena; Pawłowski, Maciej; Bojarski, Andrzej J; Wesołowska, Anna; Zajdel, Paweł

    2015-03-01

    A 26-membered library of novel long-chain arylpiperazines, which contained primary and tertiary amides of cyclic amino acids (proline and 1,2,3,4-tetrahydroisoquinoline-3-carboxamide) in the terminal fragment was synthesized and biologically evaluated for binding affinity for 5-HT7 and 5-HT1A receptors. Docking studies confirmed advantages of Tic-amide over Pro-amide fragment for interaction with 5-HT7 receptors. Selected compounds 32 and 28, which behaved as 5-HT7Rs antagonist and 5-HT1A partial agonist, respectively, produced antidepressant-like effects in the forced swim test in mice after acute treatment in doses of 10 mg/kg (32) and 1.25 mg/kg (28). Compound 32 reduced immobility in a manner similar to the selective 5-HT7 antagonist SB-269970. PMID:25555143

  13. Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice

    PubMed Central

    DEMİRKAYA, Kadriye; AKGÜN, Özlem Martı; ŞENEL, Buğra; ÖNCEL TORUN, Zeynep; SEYREK, Melik; LACİVİTA, Enza; LEOPOLDO, Marcello; DOĞRUL, Ahmet

    2016-01-01

    ABSTRACT The most recently identified serotonin (5-HT) receptor is the 5-HT7 receptor. The antinociceptive effects of a 5-HT7 receptor agonist have been shown in neuropathic and inflammatory animal models of pain. A recent study demonstrated the functional expression of 5-HT7 receptors in the substantia gelatinosa (SG) of the trigeminal subnucleus caudalis, which receives and processes orofacial nociceptive inputs. Objective To investigate the antinociceptive effects of pharmacological activation of 5-HT7 receptors on orofacial pain in mice. Material and Methods Nociception was evaluated by using an orofacial formalin test in male Balb-C mice. Selective 5-HT7 receptor agonists, LP 44 and LP 211 (1, 5, and 10 mg/kg), were given intraperitoneally 30 min prior to a formalin injection. A bolus of 10 µl of 4% subcutaneous formalin was injected into the upper lip of mice and facial grooming behaviors were monitored. The behavioral responses consisted of two distinct periods, the early phase corresponding to acute pain (Phase I: 0–12 min) and the late phase (Phase II: 12–30 min). Results LP 44 and LP 211 (1, 5, and 10 mg/kg) produced an analgesic effect with reductions in face rubbing time in both Phase I and Phase II of the formalin test. Conclusion Our results suggest that 5-HT7 receptor agonists may be promising analgesic drugs in the treatment of orofacial pain. PMID:27383702

  14. Effect of 5-HT7 receptor agonist, LP-211, on micturition following spinal cord injury in male rats

    PubMed Central

    Norouzi-Javidan, Abbas; Javanbakht, Javad; Barati, Fardin; Fakhraei, Nahid; Mohammadi, Fatemeh; Dehpour, Ahmad Reza

    2016-01-01

    Background and Purpose: Central and peripheral 5-hydroxytryptamine (5-HT) receptors play a critical role in regulation of micturition reflex. The aim of this study was to evaluate effect of a 5-HT7 receptor agonist, LP-211 (N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide) on micturition reflex in acute spinal cord-injured (SCI) rats during infusion of vehicle into the bladder. Methods: SCI was induced by compressing T10 segment using an aneurysm clip, extradurally in male rats. Following two weeks, LP-211 doses (0.003-0.3 mg/kg) were administered cumulatively (intraperitoneally, i.p.) with 20 min interval. The 5-HT7 antagonist, SB-269970 ((R)-3-[2-[2-(4-Methylpiperidin-1-yl) ethyl] pyrrolidine-1-sulfonyl] phenol hydrochloride), was administered after achievement of LP-211 dose-response. A cystometric study was performed 2 weeks after spinal crushing in all the animals. Cystometric variables consisting of micturition volume (voided volume), residual volume (volume remaining in the bladder after voiding), and bladder capacity (micturition volume plus residual volume). Voiding efficiency was calculated as the percent of micturition volume to bladder capacity. Findings: Intact and sham-operated rats showed few significant changes in micturition reflex. SCI rats responded to LP-211 (0.003-0.3, mg/kg, i.v.) with dose-dependent increases in bladder capacity, and residual volume. In this treatment group, LP-211 induced significant dose-dependent increases in micturition volume, resulting in significant increases in voiding efficiency (P<0.001) compared to intact and sham-operated rats, SB-269970 (0.1 mg/kg, i.v.) completely reversed the LP-211-induced changes on micturition volume and voiding efficiency was decreased significantly. Conclusion: The 5-HT7 receptors activation by LP-211 facilitated the micturition reflex. Furthermore, 5-HT7 receptors do seem to play an important role in physiological regulation of micturition, and as a result, may represent a

  15. Effects of acupuncture at HT7 on glucose metabolism in a rat model of Alzheimer's disease: an 18F-FDG-PET study

    PubMed Central

    Lai, Xinsheng; Ren, Jie; Lu, Yangjia; Cui, Shaoyang; Chen, Junqi; Huang, Yong; Tang, Chunzhi; Shan, Baoci; Nie, Bingbing

    2016-01-01

    Objective To explore the effects of acupuncture at HT7 on different cerebral regions in a rat model of Alzheimer's disease (AD) with the application of 18F-2-fluoro-deoxy-D-glucose positron emission tomography (FDG-PET). Methods Sixty Wistar rats were included after undergoing a Y-maze electric sensitivity test. Ten rats were used as a healthy control group. The remaining 50 rats were injected stereotaxically with ibotenic acid into the right nucleus basalis magnocellularis and injected intraperitoneally with D-galactose. AD was successfully modelled in 36 rats, which were randomly divided into three groups (n=12 each): the AD group, which remained untreated; the AD+HT7 group, which received 20 sessions of acupuncture at HT7 over 1 month; and the AD+Sham group, which received acupuncture at a distant non-acupuncture point. Total reaction time (TRT) was measured by Y-maze and 18F-FDG-PET scans were conducted on day 1 and 30. PET images were processed with Statistical Parametric Mapping 8.0. Results Pre-treatment, TRT was greater in all AD groups versus controls (mean±SD 24.10±2.48 vs 41.34±5.00 s). Post-treatment, TRT was shortened in AD+HT7 versus AD+Sham and AD groups (p<0.0001, two-way analysis of variance). Glucose metabolic activity in the hippocampus, thalamus, hypothalamus, frontal lobe, and temporal lobe was decreased in AD rats compared with healthy controls and relatively elevated after HT7 acupuncture. Compared with sham acupuncture, HT7 needling had a greater positive influence on brain glucose metabolism. Conclusions Needling at HT7 can improve memory ability and cerebral glucose metabolic activity of the hippocampus, thalamus, hypothalamus, and frontal/temporal lobes in an AD rat model. PMID:26654890

  16. Autoradiographic distribution of 5-HT7 receptors in the human brain using [3H]mesulergine: comparison to other mammalian species

    PubMed Central

    Martín-Cora, Francisco J; Pazos, Angel

    2003-01-01

    The main aim of this investigation was to delineate the distribution of the 5-HT7 receptor in human brain. Autoradiographic studies in guinea-pig and rat brain were also carried out in order to revisit and compare the anatomical distribution of 5-HT7 receptors in different mammalian species.Binding studies were performed in rat frontal cortex membranes using 10 nM [3H]mesulergine in the presence of raclopride (10 μM) and DOI (0.8 μM). Under these conditions, a binding site with pharmacological characteristics consistent with those of the 5-HT7 receptors was identified (rank order of binding affinity values: 5-CT>5-HT>5-MeOT>mesulergine ≈methiothepin>8-OH-DPAT=spiperone ≈(+)-butaclamol≫imipramine ≈(±)-pindolol≫ondansetron ≈clonidine ≈prazosin).The autoradiographic studies revealed that the anatomical distribution of 5-HT7 receptors throughout the human brain was heterogenous. High densities were found over the caudate and putamen nuclei, the pyramidal layer of the CA2 field of the hippocampus, the centromedial thalamic nucleus, and the dorsal raphe nucleus. The inner layer of the frontal cortex, the dentate gyrus of the hippocampus, the subthalamic nucleus and superior colliculus, among others, presented intermediate concentrations of 5-HT7 receptors. A similar brain anatomical distribution of 5-HT7 receptors was observed in all three mammalian species studied.By using [3H]mesulergine, we have mapped for the first time the anatomical distribution of 5-HT7 receptors in the human brain, overcoming the limitations previously found in radiometric studies with other radioligands, and also revisiting the distribution in guinea-pig and rat brain. PMID:14656806

  17. Observation of instabilities during density limit experiments in the Hefei Tokamak-7

    SciTech Connect

    Asif, M.

    2007-06-15

    During a recent campaign at the Hefei Tokamak-7 (HT-7) [M. Asif et al., Phys. Plasmas 12, 082502 (2005)], experiments were performed with a moveable graphite limiter to investigate the influence of the horizontal plasma position on the density limit. It has been found that in HT-7 density limits differ by the radiative instability in the plasma boundary and various magnetohydrodynamic (MHD) instabilities, which precedes the disruption. Control of the impurity content, edge, and recycling properties prevents the growth of the multifaceted asymmetric radiation from the edge (MARFE) and makes it possible to exceed the Greenwald limit in HT-7. It has been observed that the m=2, MHD component dominates during almost the whole discharge duration, when the density limit is approached at values of the edge safety factor 3HT-7 tokamak.

  18. Plasma density behavior in the Hefei tokamak-7

    NASA Astrophysics Data System (ADS)

    Gao, Xiang; Jie, Y. X.; Yang, Y.; Xia, C. Y.; Wei, M. S.; Zhang, S. Y.; Cheng, Y. F.; Hu, L. Q.; Mao, J. S.; Tong, X. D.; Wan, B. N.; Kuang, G. L.; Li, J. G.; Zhao, Y. P.; Luo, J. R.; Qiu, N.; Yang, K.; Li, G.; Xie, J. K.; Wan, Y. X.

    2000-07-01

    The density profiles were measured in the Hefei tokamak-7 (HT-7) [World Survey of Activities in Controlled Fusion Research, Nuclear Fusion Special Supplement (International Atomic Energy Agency, Vienna, 1997), p. 61] ohmic discharges by means of a new multichannel far-infrared (FIR) laser interferometer. The progress on the extension of the HT-7 ohmic discharge operation region was introduced. The experiment results at the density limit, the multifaceted asymmetric radiation from the edge (MARFE) phenomena, the rf (radio frequency) boronization experiments, and the fueling efficiency studies were reported. The plasma physics in the molecular beam injection (MBI), the pellet injection (PI), and the gas puffing (GP) fueling experiments was studied and discussed.

  19. Antiallodynic effect of tianeptine via modulation of the 5-HT7 receptor of GABAergic interneurons in the spinal cord of neuropathic rats.

    PubMed

    Lin, Hai; Heo, Bong Ha; Kim, Woong Mo; Kim, Yong Chul; Yoon, Myung Ha

    2015-06-26

    Although tianeptine, an atypical antidepressant has been reported to have antinociceptive effects, the mode of action is different from that of tricyclic antidepressants despite structural similarities. We examined the antiallodynic effect of intrathecal tianeptine in neuropathic pain rats and determined the involvement of 5-hydroxytryptamine type 7 (5-HT7) receptor of the GABAergic interneurons in the spinal cord. Neuropathic pain was induced by spinal nerve ligation (SNL). After observation of the effect from intrathecal tianeptine, a 5-HT7 receptor antagonist (SB-269970) was administered intrathecally 10 min before delivery of tianeptine, to determine the contribution of spinal 5-HT7 receptor on the activity of tianeptine. GAD expression and GABA concentrations were assessed. Intrathecal tianeptine dose-dependently attenuated mechanical allodynia in SNL rats. Pre-treatment with intrathecal SB-269970 reversed the antiallodynic effect of tianeptine. Both GAD65 expression and the GABA concentration in the spinal cord were decreased in neuropathic rats but were increased by tianeptine. Additionally, 5-HT7 receptor and GAD65 were co-localized in the spinal cord. Intrathecal tianeptine reduces neuropathic pain. 5-HT7 receptor of the GABAergic interneurons together with GAD65 plays a role in the activity of tianeptine at the spinal cord level. PMID:25982324

  20. Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity

    PubMed Central

    Shelton, Jonathan; Yun, Sujin; Losee Olson, Susan; Turek, Fred; Bonaventure, Pascal; Dvorak, Curt; Lovenberg, Timothy; Dugovic, Christine

    2015-01-01

    Recent reports have illustrated a reciprocal relationship between circadian rhythm disruption and mood disorders. The 5-HT7 receptor may provide a crucial link between the two sides of this equation since the receptor plays a critical role in sleep, depression, and circadian rhythm regulation. To further define the role of the 5-HT7 receptor as a potential pharmacotherapy to correct circadian rhythm disruptions, the current study utilized the selective 5-HT7 antagonist JNJ-18038683 (10 mg/kg) in three different circadian paradigms. While JNJ-18038683 was ineffective at phase shifting the onset of wheel running activity in mice when administered at different circadian time (CT) points across the circadian cycle, pretreatment with JNJ-18038683 blocked non-photic phase advance (CT6) induced by the 5-HT1A/7 receptor agonist 8-OH-DPAT (3 mg/kg). Since light induced phase shifts in mammals are partially mediated via the modulation of the serotonergic system, we determined if JNJ-18038683 altered phase shifts induced by a light pulse at times known to phase delay (CT15) or advance (CT22) wheel running activity in free running mice. Light exposure resulted in a robust shift in the onset of activity in vehicle treated animals at both times tested. Administration of JNJ-18038683 significantly attenuated the light induced phase delay and completely blocked the phase advance. The current study demonstrates that pharmacological blockade of the 5-HT7 receptor by JNJ-18038683 blunts both non-photic and photic phase shifts of circadian wheel running activity in mice. These findings highlight the importance of the 5-HT7 receptor in modulating circadian rhythms. Due to the opposite modulating effects of light resetting between diurnal and nocturnal species, pharmacotherapy targeting the 5-HT7 receptor in conjunction with bright light therapy may prove therapeutically beneficial by correcting the desynchronization of internal rhythms observed in depressed individuals. PMID:25642174

  1. Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis

    PubMed Central

    Impellizzeri, Agata Antonina Rita; Pappalardo, Matteo; Basile, Livia; Manfra, Ornella; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Messina, Angela; Levy, Finn Olav; Guccione, Salvatore

    2015-01-01

    The human 5-HT7 receptor is expressed in both the central nervous system and peripheral tissues and is a potential drug target in behavioral and psychiatric disorders. We examined molecular determinants of ligand binding and G protein activation by the human 5-HT7(a) receptor. The role of several key residues in the 7th transmembrane domain (TMD) and helix 8 were elucidated combining in silico and experimental mutagenesis. Several single and two double point mutations of the 5-HT7(a) wild type receptor were made (W7.33V, E7.35T, E7.35R, E7.35D, E7.35A, R7.36V, Y7.43A, Y7.43F, Y7.43T, R8.52D, D8.53K; E7.35T-R7.36V, R8.52D-D8.53K), and their effects upon ligand binding were assessed by radioligand binding using a potent agonist (5-CT) and a potent antagonist (SB269970). In addition, the ability of the mutated 5-HT7(a) receptors to activate G protein after 5-HT-stimulation was determined through activation of adenylyl cyclase. In silico investigation on mutated receptors substantiated the predicted importance of TM7 and showed critical roles of residues E7.35, W7.33, R7.36 and Y7.43 in agonist and antagonist binding and conformational changes of receptor structure affecting adenylyl cyclase activation. Experimental data showed that mutants E7.35T and E7.35R were incapable of ligand binding and adenylyl cyclase activation, consistent with a requirement for a negatively charged residue at this position. The mutant R8.52D was unable to activate adenylyl cyclase, despite unaffected ligand binding, consistent with the R8.52 residue playing an important role in the receptor-G protein interface. The mutants Y7.43A and Y7.43T displayed reduced agonist binding and AC agonist potency, not seen in Y7.43F, consistent with a requirement for an aromatic residue at this position. Knowledge of the molecular interactions important in h5-HT7 receptor ligand binding and G protein activation will aid the design of selective h5-HT7 receptor ligands for potential pharmacological use. PMID

  2. Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis.

    PubMed

    Impellizzeri, Agata Antonina Rita; Pappalardo, Matteo; Basile, Livia; Manfra, Ornella; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Messina, Angela; Levy, Finn Olav; Guccione, Salvatore

    2015-01-01

    The human 5-HT7 receptor is expressed in both the central nervous system and peripheral tissues and is a potential drug target in behavioral and psychiatric disorders. We examined molecular determinants of ligand binding and G protein activation by the human 5-HT7(a) receptor. The role of several key residues in the 7th transmembrane domain (TMD) and helix 8 were elucidated combining in silico and experimental mutagenesis. Several single and two double point mutations of the 5-HT7(a) wild type receptor were made (W7.33V, E7.35T, E7.35R, E7.35D, E7.35A, R7.36V, Y7.43A, Y7.43F, Y7.43T, R8.52D, D8.53K; E7.35T-R7.36V, R8.52D-D8.53K), and their effects upon ligand binding were assessed by radioligand binding using a potent agonist (5-CT) and a potent antagonist (SB269970). In addition, the ability of the mutated 5-HT7(a) receptors to activate G protein after 5-HT-stimulation was determined through activation of adenylyl cyclase. In silico investigation on mutated receptors substantiated the predicted importance of TM7 and showed critical roles of residues E7.35, W7.33, R7.36 and Y7.43 in agonist and antagonist binding and conformational changes of receptor structure affecting adenylyl cyclase activation. Experimental data showed that mutants E7.35T and E7.35R were incapable of ligand binding and adenylyl cyclase activation, consistent with a requirement for a negatively charged residue at this position. The mutant R8.52D was unable to activate adenylyl cyclase, despite unaffected ligand binding, consistent with the R8.52 residue playing an important role in the receptor-G protein interface. The mutants Y7.43A and Y7.43T displayed reduced agonist binding and AC agonist potency, not seen in Y7.43F, consistent with a requirement for an aromatic residue at this position. Knowledge of the molecular interactions important in h5-HT7 receptor ligand binding and G protein activation will aid the design of selective h5-HT7 receptor ligands for potential pharmacological use. PMID

  3. Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.

    PubMed

    Costa, Lara; Sardone, Lara M; Lacivita, Enza; Leopoldo, Marcello; Ciranna, Lucia

    2015-01-01

    Serotonin 5-HT7 receptors are expressed in the hippocampus and modulate the excitability of hippocampal neurons. We have previously shown that 5-HT7 receptors modulate glutamate-mediated hippocampal synaptic transmission and long-term synaptic plasticity. In particular, we have shown that activation of 5-HT7 receptors reversed metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD) in wild-type (wt) and in Fmr1 KO mice, a mouse model of Fragile X Syndrome in which mGluR-LTD is abnormally enhanced, suggesting that 5-HT7 receptor agonists might be envisaged as a novel therapeutic strategy for Fragile X Syndrome. In this perspective, we have characterized the basic in vitro pharmacokinetic properties of novel molecules with high binding affinity and selectivity for 5-HT7 receptors and we have tested their effects on synaptic plasticity using patch clamp on acute hippocampal slices. Here we show that LP-211, a high affinity selective agonist of 5-HT7 receptors, reverses mGluR-LTD in wt and Fmr1 KO mice, correcting a synaptic malfunction in the mouse model of Fragile X Syndrome. Among novel putative agonists of 5-HT7 receptors, the compound BA-10 displayed improved affinity and selectivity for 5-HT7 receptors and improved in vitro pharmacokinetic properties with respect to LP-211. BA-10 significantly reversed mGluR-LTD in the CA3-CA1 synapse in wt and Fmr1KO mice, indicating that BA-10 behaved as a highly effective agonist of 5-HT7 receptors and reduced exaggerated mGluR-LTD in a mouse model of Fragile X Syndrome. On the other side, the compounds RA-7 and PM-20, respectively arising from in vivo metabolism of LP-211 and BA-10, had no effect on mGluR-LTD thus did not behave as agonists of 5-HT7 receptors in our conditions. The present results provide information about the structure-activity relationship of novel 5-HT7 receptor agonists and indicate that LP-211 and BA-10 might be used as novel pharmacological tools for the therapy of Fragile X Syndrome

  4. ECH tokamak

    SciTech Connect

    Firestone, M.A.; Mau, T.K.; Conn, R.W.

    1985-04-01

    A small steady-state tokamak capable of producing power in the 100 to 300 MWe range and relying on electron cyclotron RF heating (ECH) for both heating and current drive is described. Working in the first MHD stability regime for tokamaks, the approach adheres to the recently discovered maximum beta limit. An appropriate figure of merit is the ratio of the fusion power to absorbed RF power. Efficient devices are feasible at both small and large values of fusion power, thereby pointing to a development path for an attractive commercial fusion reactor.

  5. An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7 and 5-HT1A Receptor Partial Agonist that Corrects Motor Stereotypy in Mouse Models.

    PubMed

    Canal, Clinton E; Felsing, Daniel E; Liu, Yue; Zhu, Wanying; Wood, JodiAnne T; Perry, Charles K; Vemula, Rajender; Booth, Raymond G

    2015-07-15

    Stereotypy (e.g., repetitive hand waving) is a key phenotype of autism spectrum disorder, Fragile X and Rett syndromes, and other neuropsychiatric disorders, and its severity correlates with cognitive and attention deficits. There are no effective treatments, however, for stereotypy. Perturbation of serotonin (5-HT) neurotransmission contributes to stereotypy, suggesting that distinct 5-HT receptors may be pharmacotherapeutic targets to treat stereotypy and related neuropsychiatric symptoms. For example, preclinical studies indicate that 5-HT7 receptor activation corrects deficits in mouse models of Fragile X and Rett syndromes, and clinical trials for autism are underway with buspirone, a 5-HT1A partial agonist with relevant affinity at 5-HT7 receptors. Herein, we report the synthesis, in vitro molecular pharmacology, behavioral pharmacology, and pharmacokinetic parameters in mice after subcutaneous and oral administration of (+)-5-(2'-fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine ((+)-5-FPT), a new, dual partial agonist targeting both 5-HT7 (Ki = 5.8 nM, EC50 = 34 nM) and 5-HT1A (Ki = 22 nM, EC50 = 40 nM) receptors. Three unique, heterogeneous mouse models were used to assess the efficacy of (+)-5-FPT to reduce stereotypy: idiopathic jumping in C58/J mice, repetitive body rotations in C57BL/6J mice treated with the NMDA antagonist, MK-801, and repetitive head twitching in C57BL/6J mice treated with the 5-HT2 agonist, DOI. Systemic (+)-5-FPT potently and efficaciously reduced or eliminated stereotypy in each of the mouse models without altering locomotor behavior on its own, and additional tests showed that (+)-5-FPT, at the highest behaviorally active dose tested, enhanced social interaction and did not cause behaviors indicative of serotonin syndrome. These data suggest that (+)-5-FPT is a promising medication for treating stereotypy in psychiatric disorders. PMID:26011730

  6. A flowing liquid lithium limiter for the Experimental Advanced Superconducting Tokamak.

    PubMed

    Ren, J; Zuo, G Z; Hu, J S; Sun, Z; Yang, Q X; Li, J G; Zakharov, L E; Xie, H; Chen, Z X

    2015-02-01

    A program involving the extensive and systematic use of lithium (Li) as a "first," or plasma-facing, surface in Tokamak fusion research devices located at Institute of Plasma Physics, Chinese Academy of Sciences, was started in 2009. Many remarkable results have been obtained by the application of Li coatings in Experimental Advanced Superconducting Tokamak (EAST) and liquid Li limiters in the HT-7 Tokamak-both located at the institute. In furtherance of the lithium program, a flowing liquid lithium (FLiLi) limiter system has been designed and manufactured for EAST. The design of the FLiLi limiter is based on the concept of a thin flowing film which was previously tested in HT-7. Exploiting the capabilities of the existing material and plasma evaluation system on EAST, the limiter will be pre-wetted with Li and mechanically translated to the edge of EAST during plasma discharges. The limiter will employ a novel electro-magnetic pump which is designed to drive liquid Li flow from a collector at the bottom of limiter into a distributor at its top, and thus supply a continuously flowing liquid Li film to the wetted plasma-facing surface. This paper focuses on the major design elements of the FLiLi limiter. In addition, a simulation of incoming heat flux has shown that the distribution of heat flux on the limiter surface is acceptable for a future test of power extraction on EAST. PMID:25725839

  7. Study of the DEF Feedback Control System in AC Operation of Superconducting Tokamak

    NASA Astrophysics Data System (ADS)

    Wang, Hua; Luo, Jiarong; Yuan, Qiping; Xu, Congdong

    2007-02-01

    AC operation with multiple full cycles has been successfully performed on the superconducting tokamak HT-7. In the experiment, it was discovered that the saturation of the transformer magnetic flux with DEF, a signal name, was one of key aspects that affected the AC operation. The conditions of DEF were examined through the DEF feedback control system. By controlling the working patterns of the subsystems, namely the poloidal field control system and density control system, it was guaranteed that DEF would remain in the non-saturated status.

  8. A flowing liquid lithium limiter for the Experimental Advanced Superconducting Tokamak

    SciTech Connect

    Ren, J.; Zuo, G. Z.; Hu, J. S.; Sun, Z.; Yang, Q. X.; Li, J. G.; Xie, H.; Chen, Z. X.; Zakharov, L. E.

    2015-02-15

    A program involving the extensive and systematic use of lithium (Li) as a “first,” or plasma-facing, surface in Tokamak fusion research devices located at Institute of Plasma Physics, Chinese Academy of Sciences, was started in 2009. Many remarkable results have been obtained by the application of Li coatings in Experimental Advanced Superconducting Tokamak (EAST) and liquid Li limiters in the HT-7 Tokamak—both located at the institute. In furtherance of the lithium program, a flowing liquid lithium (FLiLi) limiter system has been designed and manufactured for EAST. The design of the FLiLi limiter is based on the concept of a thin flowing film which was previously tested in HT-7. Exploiting the capabilities of the existing material and plasma evaluation system on EAST, the limiter will be pre-wetted with Li and mechanically translated to the edge of EAST during plasma discharges. The limiter will employ a novel electro-magnetic pump which is designed to drive liquid Li flow from a collector at the bottom of limiter into a distributor at its top, and thus supply a continuously flowing liquid Li film to the wetted plasma-facing surface. This paper focuses on the major design elements of the FLiLi limiter. In addition, a simulation of incoming heat flux has shown that the distribution of heat flux on the limiter surface is acceptable for a future test of power extraction on EAST.

  9. Simulations of the L-H transition on experimental advanced superconducting Tokamak

    SciTech Connect

    Weiland, Jan

    2014-12-15

    We have simulated the L-H transition on the EAST tokamak [Baonian Wan, EAST and HT-7 Teams, and International Collaborators, “Recent experiments in the EAST and HT-7 superconducting tokamaks,” Nucl. Fusion 49, 104011 (2009)] using a predictive transport code where ion and electron temperatures, electron density, and poloidal and toroidal momenta are simulated self consistently. This is, as far as we know, the first theory based simulation of an L-H transition including the whole radius and not making any assumptions about where the barrier should be formed. Another remarkable feature is that we get H-mode gradients in agreement with the α – α{sub d} diagram of Rogers et al. [Phys. Rev. Lett. 81, 4396 (1998)]. Then, the feedback loop emerging from the simulations means that the L-H power threshold increases with the temperature at the separatrix. This is a main feature of the C-mod experiments [Hubbard et al., Phys. Plasmas 14, 056109 (2007)]. This is also why the power threshold depends on the direction of the grad B drift in the scrape off layer and also why the power threshold increases with the magnetic field. A further significant general H-mode feature is that the density is much flatter in H-mode than in L-mode.

  10. A flowing liquid lithium limiter for the Experimental Advanced Superconducting Tokamak

    NASA Astrophysics Data System (ADS)

    Ren, J.; Zuo, G. Z.; Hu, J. S.; Sun, Z.; Yang, Q. X.; Li, J. G.; Zakharov, L. E.; Xie, H.; Chen, Z. X.

    2015-02-01

    A program involving the extensive and systematic use of lithium (Li) as a "first," or plasma-facing, surface in Tokamak fusion research devices located at Institute of Plasma Physics, Chinese Academy of Sciences, was started in 2009. Many remarkable results have been obtained by the application of Li coatings in Experimental Advanced Superconducting Tokamak (EAST) and liquid Li limiters in the HT-7 Tokamak—both located at the institute. In furtherance of the lithium program, a flowing liquid lithium (FLiLi) limiter system has been designed and manufactured for EAST. The design of the FLiLi limiter is based on the concept of a thin flowing film which was previously tested in HT-7. Exploiting the capabilities of the existing material and plasma evaluation system on EAST, the limiter will be pre-wetted with Li and mechanically translated to the edge of EAST during plasma discharges. The limiter will employ a novel electro-magnetic pump which is designed to drive liquid Li flow from a collector at the bottom of limiter into a distributor at its top, and thus supply a continuously flowing liquid Li film to the wetted plasma-facing surface. This paper focuses on the major design elements of the FLiLi limiter. In addition, a simulation of incoming heat flux has shown that the distribution of heat flux on the limiter surface is acceptable for a future test of power extraction on EAST.

  11. The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling.

    PubMed

    Atanes, Patricio; Lacivita, Enza; Rodríguez, Javier; Brea, José; Burgueño, Javier; Vela, José Miguel; Cadavid, María Isabel; Loza, María Isabel; Leopoldo, Marcello; Castro, Marián

    2013-12-01

    We performed a detailed in vitro pharmacological characterization of two arylpiperazine derivatives, compound N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide (LP-211) previously identified as a high-affinity brain penetrant ligand for 5-hydroxytryptamine (serotonin) type 7 (5-HT7) receptors, and its analog N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide (MEL-9). Both ligands exhibited competitive displacement of [(3)H]-(2R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine ([(3)H]-SB-269970) radioligand binding and insurmountable antagonism of 5-carboxamidotryptamine (5-CT)-stimulated cyclic adenosine monophosphate (cAMP) signaling in human embryonic kidney (HEK293) cells stably expressing human 5-HT7 receptors. They also inhibited forskolin-stimulated adenylate cyclase activity in 5-HT7-expressing HEK293 cells but not in the parental cell line. The compounds elicited long-lasting (at least 24 h) concentration-dependent inhibition of radioligand binding at 5-HT7-binding sites in whole-cell radioligand binding assays, after pretreatment of the cells with the compounds and subsequent compound removal. In cAMP assays, pretreatment of cells with the compounds rendered 5-HT7 receptors unresponsive to 5-CT and also rendered 5-HT7-expressing HEK293 cells unresponsive to forskolin. Compound 1-(2-biphenyl)piperazine (RA-7), a known active metabolite of LP-211 present in vivo, was able to partially inhibit 5-HT7 radioligand binding in a long-lasting irreversible manner. Hence, LP-211 and MEL-9 were identified as high-affinity long-acting inhibitors of human 5-HT7 receptor binding and function in cell lines. The detailed in vitro characterization of these two pharmacological tools targeting 5-HT7 receptors may benefit the study of 5-HT7 receptor function and it may lead to the development of novel selective pharmacological tools with defined functional properties at 5-HT7 receptors. PMID:25505568

  12. Multiscale coherent structures in tokamak plasma turbulence

    SciTech Connect

    Xu, G. S.; Wan, B. N.; Zhang, W.; Yang, Q. W.; Wang, L.; Wen, Y. Z.

    2006-10-15

    A 12-tip poloidal probe array is used on the HT-7 superconducting tokamak [Li, Wan, and Mao, Plasma Phys. Controlled Fusion 42, 135 (2000)] to measure plasma turbulence in the edge region. Some statistical analysis techniques are used to characterize the turbulence structures. It is found that the plasma turbulence is composed of multiscale coherent structures, i.e., turbulent eddies and there is self-similarity in a relative short scale range. The presence of the self-similarity is found due to the structural similarity of these eddies between different scales. These turbulent eddies constitute the basic convection cells, so the self-similar range is just the dominant scale range relevant to transport. The experimental results also indicate that the plasma turbulence is dominated by low-frequency and long-wavelength fluctuation components and its dispersion relation shows typical electron-drift-wave characteristics. Some large-scale coherent structures intermittently burst out and exhibit a very long poloidal extent, even longer than 6 cm. It is found that these large-scale coherent structures are mainly contributed by the low-frequency and long-wavelength fluctuating components and their presence is responsible for the observations of long-range correlations, i.e., the correlation in the scale range much longer than the turbulence decorrelation scale. These experimental observations suggest that the coexistence of multiscale coherent structures results in the self-similar turbulent state.

  13. Nature of 5-HT1-like receptors mediating depressor responses in vagosympathectomized rats; close resemblance to the cloned 5-ht7 receptor.

    PubMed

    De Vries, P; Villalón, C M; Heiligers, J P; Saxena, P R

    1997-07-01

    It has been suggested that the late hypotensive response to serotonin (5-hydroxytryptamine; 5-HT) in vagosympathectomized rats is mediated by '5-HT1-like' receptors since this effect is mimicked by 5-carboxamidotryptamine (5-CT), is not modified by cyproheptadine, ketanserin or MDL 72222, but it is blocked by methysergide. The present study was set out to reanalyze this suggestion in terms of the classification schemes proposed in 1994 and 1996 by the NC-IUPHAR subcommittee on the classification and nomenclature of 5-HT receptors. I.v. bolus injections of 5-CT (0.01-0.3 microg x kg(-1)), 5-HT (1-30 microg x kg(-1)) and 5-methoxytryptamine (5-MeO-T; 1-30 microg x kg(-1)) produced dose-dependent hypotensive responses with a rank order of agonist potency: 5-CT > 5-HT > 5-methoxytryptamine with sumatriptan (30-1000 microg x kg(-1)) inactive. The depressor responses to 5-HT and 5-CT were not attenuated by i.v. GR127935 (300-3000 microg x kg(-1)) or equivalent volumes of saline. In contrast, lisuride, methiothepin, mesulergine, metergoline and clozapine dose-dependently antagonized the responses to 5-HT and 5-CT; the rank order of apparent pA2 values against 5-HT and 5-CT, respectively, was: lisuride (7.7; 7.8) > methiothepin (6.8; 7.0) > or = mesulergine (6.4; 6.6) > clozapine (5.7; 5.8); metergoline displayed variable potencies (5.6; 6.4). Except for lisuride, which also affected isoprenaline-induced hypotension, the antagonism by the other drugs was selective. Based upon the above rank order of agonist potency, the blockade by a series of drugs showing high affinity for the cloned 5-ht7 receptor and the lack of blockade by GR127935, our results indicate that the 5-HT receptor mediating hypotension in vagosympathectomized rats is operationally similar to other putative 5-ht7 receptors mediating vascular and non-vascular responses (e.g. relaxation of the rabbit femoral vein, canine coronary and external carotid arteries and guinea-pig ileum as well as feline tachycardia

  14. Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study.

    PubMed

    Lacivita, Enza; Podlewska, Sabina; Speranza, Luisa; Niso, Mauro; Satała, Grzegorz; Perrone, Roberto; Perrone-Capano, Carla; Bojarski, Andrzej J; Leopoldo, Marcello

    2016-09-14

    The 5-HT7 serotonin receptor is revealing a promising target for innovative therapeutic strategies of neurodevelopmental and neuropsychiatric disorders. Here, we report the synthesis of thirty long-chain arylpiperazine analogs of the selective and brain penetrant 5-HT7 receptor agonist LP-211 (1) designed to enhance stability towards microsomal oxidative metabolism. Commonly used medicinal chemistry strategies were used (i.e., reduction of overall lipophilicity, introduction of electron-withdrawing groups, blocking of potential vulnerable sites of metabolism), and in vitro microsomal stability was tested. The data showed that the adopted design strategy does not directly translate into improvements in stability. Instead, the metabolic stability of the compounds was related to the presence of specific substituents in well-defined regions of the molecule. The collected data allowed for the construction of a machine learning model that, in a given chemical space, is able to describe and quantitatively predict the metabolic stability of the compounds. The majority of the synthesized compounds maintained high affinity for 5-HT7 receptors and showed selectivity towards 5-HT6 and dopamine D2 receptors and different selectivity for 5-HT1A and α1 adrenergic receptors. Compound 50 showed 3-fold higher in vitro stability towards oxidative metabolism than 1 and was able to stimulate neurite outgrowth in neuronal primary cultures through the 5-HT7 receptor in a shorter time and at a lower concentration than the agonist 1. A preliminary disposition study in mice revealed that compound 50 was metabolically stable and was able to pass the blood-brain barrier, thus representing a new tool for studying the pharmacotherapeutic potential of 5-HT7 receptor in vivo. PMID:27318552

  15. An Algorithm to Identify Target-Selective Ligands – A Case Study of 5-HT7/5-HT1A Receptor Selectivity

    PubMed Central

    Kurczab, Rafał; Canale, Vittorio; Zajdel, Paweł; Bojarski, Andrzej J.

    2016-01-01

    A computational procedure to search for selective ligands for structurally related protein targets was developed and verified for serotonergic 5-HT7/5-HT1A receptor ligands. Starting from a set of compounds with annotated activity at both targets (grouped into four classes according to their activity: selective toward each target, not-selective and not-selective but active) and with an additional set of decoys (prepared using DUD methodology), the SVM (Support Vector Machines) models were constructed using a selective subset as positive examples and four remaining classes as negative training examples. Based on these four component models, the consensus classifier was then constructed using a data fusion approach. The combination of two approaches of data representation (molecular fingerprints vs. structural interaction fingerprints), different training set sizes and selection of the best SVM component models for consensus model generation, were evaluated to determine the optimal settings for the developed algorithm. The results showed that consensus models with molecular fingerprints, a larger training set and the selection of component models based on MCC maximization provided the best predictive performance. PMID:27271158

  16. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome

    SciTech Connect

    Gelernter, J.; Rao, P.A.; Pauls, D.L.

    1995-03-20

    A novel serotonin receptor designated 5HT7 (genetic locus HTR7) was cloned in 1993. This receptor has interesting properties related to ligand affinity and CNS distribution that render HTR7 a very interesting candidate gene for neuropsychiatric disorders. We mapped this gene, first by physical methods and then by genetic linkage. First, we made a tentative assignment to chromosome 10, based on hybridization of an HTR7 probe to a Southern blot of DNA from somatic cell hybrids. We then identified a genetic polymorphism at the HTR7 locus. We identified one extended pedigree where the polymorphism segregated. Using the LEPED computer program for pairwise linkage analysis, we confirmed the assignment of the gene to chromosome 10, specifically 10q21-q24, based on a lod score of 5.37 at 0% recombination between HTR7 and D10S20 (a chromosome 10 reference marker). Finally, we excluded genetic linkage between this locus and Tourette syndrome under a reasonable set of assumptions. 15 refs., 1 fig., 1 tab.

  17. Tokamak Systems Code

    SciTech Connect

    Reid, R.L.; Barrett, R.J.; Brown, T.G.; Gorker, G.E.; Hooper, R.J.; Kalsi, S.S.; Metzler, D.H.; Peng, Y.K.M.; Roth, K.E.; Spampinato, P.T.

    1985-03-01

    The FEDC Tokamak Systems Code calculates tokamak performance, cost, and configuration as a function of plasma engineering parameters. This version of the code models experimental tokamaks. It does not currently consider tokamak configurations that generate electrical power or incorporate breeding blankets. The code has a modular (or subroutine) structure to allow independent modeling for each major tokamak component or system. A primary benefit of modularization is that a component module may be updated without disturbing the remainder of the systems code as long as the imput to or output from the module remains unchanged.

  18. Mediation of 5-HT-induced external carotid vasodilatation in GR 127935-pretreated vagosympathectomized dogs by the putative 5-HT7 receptor

    PubMed Central

    Villalón, Carlos M; Centurión, David; Luján-Estrada, Miguel; Terrón, José A; Sánchez-López, Araceli

    1997-01-01

    mg kg−1) or ritanserin (100 μg kg−1) plus granisetron (300 μg kg−1), but were dose-dependently blocked by i.v. administration of methiothepin (10 and 30 μg kg−1, given after ritanserin plus granisetron), mesulergine (10 and 30 μg kg−1), metergoline (1 and 3 mg kg−1), methysergide (1 and 3 mg kg−1) or clozapine (0.3 and 1 mg kg−1). Nevertheless, the blockade of the above responses, not significant after treatment with the lower of the two doses of metergoline and mesulergine, was nonspecific after administration of the higher of the two doses of methysergide and clozapine.Based upon the above rank order of agonist potencies and the antagonism produced by a series of drugs showing high affinity for the cloned 5-ht7 receptor, our results indicate that the 5-HT receptor mediating external carotid vasodilatation in GR 127935-pretreated vagosympathectomized dogs is operationally similar to the putative 5-HT7 receptor mediating relaxation of vascular and non-vascular smooth muscles (e.g. rabbit femoral vein, canine coronary artery, rat systemic vasculature and guinea-pig ileum) as well as tachycardia in the cat. PMID:9105708

  19. Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT1A and 5-HT7 Antagonists in Animal Models

    PubMed Central

    Pytka, Karolina; Partyka, Anna; Jastrzębska-Więsek, Magdalena; Siwek, Agata; Głuch-Lutwin, Monika; Mordyl, Barbara; Kazek, Grzegorz; Rapacz, Anna; Olczyk, Adrian; Gałuszka, Adam; Błachuta, Marian; Waszkielewicz, Anna; Marona, Henryk; Sapa, Jacek; Filipek, Barbara; Wesołowska, Anna

    2015-01-01

    The aim of this study was to further characterize pharmacological properties of two phenylpiperazine derivatives: 1-{2-[2-(2,6-dimethlphenoxy)ethoxy]ethyl}-4-(2-methoxyphenyl)piperazynine hydrochloride (HBK-14) and 2-[2-(2-chloro-6-methylphenoxy)ethoxy]ethyl-4-(2- methoxyphenyl)piperazynine dihydrochloride (HBK-15) in radioligand binding and functional in vitro assays as well as in vivo models. Antidepressant-like properties were investigated in the forced swim test (FST) in mice and rats. Anxiolytic-like activity was evaluated in the four-plate test in mice and elevated plus maze test (EPM) in rats. Imipramine and escitalopram were used as reference drugs in the FST, and diazepam was used as a standard anxiolytic drug in animal models of anxiety. Our results indicate that HBK-14 and HBK-15 possess high or moderate affinity for serotonergic 5-HT2, adrenergic α1, and dopaminergic D2 receptors as well as being full 5-HT1A and 5-HT7 receptor antagonists. We also present their potent antidepressant-like activity (HBK-14—FST mice: 2.5 and 5 mg/kg; FST rats: 5 mg/kg) and (HBK-15—FST mice: 1.25, 2.5 and 5 mg/kg; FST rats: 1.25 and 2.5 mg/kg). We show that HBK-14 (four-plate test: 2.5 and 5 mg/kg; EPM: 2.5 mg/kg) and HBK-15 (four-plate test: 2.5 and 5 mg/kg; EPM: 5 mg/kg) possess anxiolytic-like properties. Among the two, HBK-15 has stronger antidepressant-like properties, and HBK-14 displays greater anxiolytic-like activity. Lastly, we demonstrate the involvement of serotonergic system, particularly 5-HT1A receptor, in the antidepressant- and anxiolytic-like actions of investigated compounds. PMID:26554929

  20. Critical role of 5-HT1A, 5-HT3, and 5-HT7 receptor subtypes in the initiation, generation, and propagation of the murine colonic migrating motor complex.

    PubMed

    Dickson, Eamonn J; Heredia, Dante J; Smith, Terence K

    2010-07-01

    The colonic migrating motor complex (CMMC) is necessary for fecal pellet propulsion in the murine colon. We have previously shown that 5-hydroxytryptamine (5-HT) released from enterochromaffin cells activates 5-HT(3) receptors on the mucosal processes of myenteric Dogiel type II neurons to initiate the events underlying the CMMC. Our aims were to further investigate the roles of 5-HT(1A), 5-HT(3), and 5-HT(7) receptor subtypes in generating and propagating the CMMC using intracellular microelectrodes or tension recordings from the circular muscle (CM) in preparations with and without the mucosa. Spontaneous CMMCs were recorded from the CM in isolated murine colons but not in preparations without the mucosa. In mucosaless preparations, ondansetron (3 microM; 5-HT(3) antagonist) plus hexamethonium (100 microM) completely blocked spontaneous inhibitory junction potentials, depolarized the CM. Ondansetron blocked the preceding hyperpolarization associated with a CMMC. Spontaneous CMMCs and CMMCs evoked by spritzing 5-HT (10 and 100 microM) or nerve stimulation in preparations without the mucosa were blocked by SB 258719 or SB 269970 (1-5 microM; 5-HT(7) antagonists). Both NAN-190 and (S)-WAY100135 (1-5 microM; 5-HT(1A) antagonists) blocked spontaneous CMMCs and neurally evoked CMMCs in preparations without the mucosa. Both NAN-190 and (S)-WAY100135 caused an atropine-sensitive depolarization of the CM. The precursor of 5-HT, 5-hydroxytryptophan (5-HTP) (10 microM), and 5-carboxamidotryptamine (5-CT) (5 microM; 5-HT(1/5/7) agonist) increased the frequency of spontaneous CMMCs. 5-HTP and 5-CT also induced CMMCs in preparations with and without the mucosa, which were blocked by SB 258719. 5-HT(1A), 5-HT(3), and 5-HT(7) receptors, most likely on Dogiel Type II/AH neurons, are important in initiating, generating, and propagating the CMMC. Tonic inhibition of the CM appears to be driven by ongoing activity in descending serotonergic interneurons; by activating 5-HT(7

  1. Modular tokamak magnetic system

    DOEpatents

    Yang, Tien-Fang

    1988-01-01

    A modular tokamak system comprised of a plurality of interlocking moldules. Each module is comprised of a vacuum vessel section, a toroidal field coil, moldular saddle coils which generate a poloidal magnetic field and ohmic heating coils.

  2. Texas Experimental Tokamak

    SciTech Connect

    Wootton, A.J.

    1993-04-01

    This progress report covers the period from November 1, 1990 to April 30, 1993. During that period, TEXT was operated as a circular tokamak with a material limiter. It was devoted to the study of basic plasma physics, in particular to study of fluctuations, turbulence, and transport. The purpose is to operate and maintain TEXT Upgrade as a complete facility for applied tokamak physics, specifically to conduct a research program under the following main headings: (1) to elucidate the mechanisms of working gas, impurity, and thermal transport in tokamaks, in particular to understand the role of turbulence; (2) to study physics of the edge plasma, in particular the turbulence; (3) to study the physics or resonant magnetic fields (ergodic magnetic divertors, intra island pumping); and (4) to study the physics of electron cyclotron heating (ECRH). Results of studies in each of these areas are reported.

  3. Completely bootstrapped tokamak

    SciTech Connect

    Weening, R.H. ); Boozer, A.H. )

    1992-01-01

    Numerical simulations of the evolution of large-scale magnetic fields have been developed using a mean-field Ohm's law. The Ohm's law is coupled to a {Delta}{prime} stabilty analysis and a magnetic island growth equation in order to simulate the behavior of tokamak plasmas that are subject to tearing modes. In one set of calculations, the magnetohydrodynamic (MHD)-stable regime of the tokamak is examined via the construction of an {ital l}{sub {ital i}} -{ital q}{sub {ital a}} diagram. The results confirm previous calculations that show that tearing modes introduce a stability boundary into the {ital l}{sub {ital i}} -{ital q}{sub {ital a}} space. In another series of simulations, the interaction between tearing modes and the bootstrap current is investigated. The results indicate that a completely bootstrapped tokamak may be possible, even in the absence of any externally applied loop voltage or current drive.

  4. Tearing Modes in Tokamaks

    NASA Astrophysics Data System (ADS)

    White, R. B.

    2008-05-01

    This lecture gives a basic introduction to magnetic £elds, magnetic surface destruction, toroidal equilibrium and tearing modes in a tokamak, including the linear and nonlinear development of these modes and their modi£cation by current drive and bootstrap current, and sawtooth oscillations and disruptions.

  5. Transport in gyrokinetic tokamaks

    SciTech Connect

    Mynick, H.E.; Parker, S.E.

    1995-01-01

    A comprehensive study of transport in full-volume gyrokinetic (gk) simulations of ion temperature gradient driven turbulence in core tokamak plasmas is presented. Though this ``gyrokinetic tokamak`` is much simpler than experimental tokamaks, such simplicity is an asset, because a dependable nonlinear transport theory for such systems should be more attainable. Toward this end, we pursue two related lines of inquiry. (1) We study the scalings of gk tokamaks with respect to important system parameters. In contrast to real machines, the scalings of larger gk systems (a/{rho}{sub s} {approx_gt} 64) with minor radius, with current, and with a/{rho}{sub s} are roughly consistent with the approximate theoretical expectations for electrostatic turbulent transport which exist as yet. Smaller systems manifest quite different scalings, which aids in interpreting differing mass-scaling results in other work. (2) With the goal of developing a first-principles theory of gk transport, we use the gk data to infer the underlying transport physics. The data indicate that, of the many modes k present in the simulation, only a modest number (N{sub k} {approximately} 10) of k dominate the transport, and for each, only a handful (N{sub p} {approximately} 5) of couplings to other modes p appear to be significant, implying that the essential transport physics may be described by a far simpler system than would have been expected on the basis of earlier nonlinear theory alone. Part of this analysis is the inference of the coupling coefficients M{sub kpq} governing the nonlinear mode interactions, whose measurement from tokamak simulation data is presented here for the first time.

  6. High Beta Tokamaks

    SciTech Connect

    Cowley, S.

    1998-11-14

    Perhaps the ideal tokamak would have high {beta} ({beta} {approx}> 1) and classical confinement. Such a tokamak has not been found, and we do not know if one does exist. We have searched for such a possibility, so far without success. In 1990, we obtained analytic equilibrium solutions for large aspect ratio tokamaks at {beta} {approx} {Omicron}(1) [1]. These solutions and the extension at high {beta} poloidal to finite aspect ratio [2] provided a basis for the study of high {beta} tokamaks. We have shown that these configurations can be stable to short scale MHD modes [3], and that they have reduced neoclassical transport [4]. Microinstabilities (such as the {del}T{sub i} mode) seem to be stabilized at high {beta} [5] - this is due to the large local shear [3] and the magnetic well. We have some concerns about modes associated with the compressional branch which may appear at high {beta}. Bill Dorland and Mike Kotschenreuther have studied this issue and our concerns may be unfounded. It is certainly tantalizing, especially given the lowered neoclassical transport values, that these configurations could have no microinstabilities and, one could assume, no anomalous transport. Unfortunately, while this work is encouraging, the key question for high {beta} tokamaks is the stability to large scale kink modes. The MHD {beta} limit (Troyon limit) for kink modes at large aspect ratio is problematically low. There is ample evidence from computations that the limit exists. However, it is not known if stable equilibria exist at much higher {beta}--none have been found. We have explored this question in the asymptotic high {beta} poloidal limit. Unfortunately, we are unable to find stable equilibrium and also unable to show that they don't exist. The results of these calculations will be published when a more definitive answer is found.

  7. Tritium catalyzed deuterium tokamaks

    SciTech Connect

    Greenspan, E.; Miley, G.H.; Jung, J.; Gilligan, J.

    1984-04-01

    A preliminary assessment of the promise of the Tritium Catalyzed Deuterium (TCD) tokamak power reactors relative to that of deuterium-tritium (D-T) and catalyzed deuterium (Cat-D) tokamaks is undertaken. The TCD mode of operation is arrived at by converting the /sup 3/He from the D(D,n)/sup 3/He reaction into tritium, by neutron capture in the blanket; the tritium thus produced is fed into the plasma. There are three main parts to the assessment: blanket study, reactor design and economic analysis and an assessment of the prospects for improvements in the performance of TCD reactors (and in the promise of the TCD mode of operation, in general).

  8. Prepuberal stimulation of 5-HT7-R by LP-211 in a rat model of hyper-activity and attention-deficit: permanent effects on attention, brain amino acids and synaptic markers in the fronto-striatal interface.

    PubMed

    Ruocco, Lucia A; Treno, Concetta; Gironi Carnevale, Ugo A; Arra, Claudio; Boatto, Gianpiero; Nieddu, Maria; Pagano, Cristina; Illiano, Placido; Barbato, Fabiana; Tino, Angela; Carboni, Ezio; Laviola, Giovanni; Lacivita, Enza; Leopoldo, Marcello; Adriani, Walter; Sadile, Adolfo G

    2014-01-01

    The cross-talk at the prefronto-striatal interface involves excitatory amino acids, different receptors, transducers and modulators. We investigated long-term effects of a prepuberal, subchronic 5-HT7-R agonist (LP-211) on adult behaviour, amino acids and synaptic markers in a model for Attention-Deficit/Hyperactivity Disorder (ADHD). Naples High Excitability rats (NHE) and their Random Bred controls (NRB) were daily treated with LP-211 in the 5th and 6th postnatal week. One month after treatment, these rats were tested for indices of activity, non selective (NSA), selective spatial attention (SSA) and emotionality. The quantity of L-Glutamate (L-Glu), L-Aspartate (L-Asp) and L-Leucine (L-Leu), dopamine transporter (DAT), NMDAR1 subunit and CAMKIIα, were assessed in prefrontal cortex (PFC), dorsal (DS) and ventral striatum (VS), for their role in synaptic transmission, neural plasticity and information processing. Prepuberal LP-211 (at lower dose) reduced horizontal activity and (at higher dose) increased SSA, only for NHE but not in NRB rats. Prepuberal LP-211 increased, in NHE rats, L-Glu in the PFC and L-Asp in the VS (at 0.250 mg/kg dose), whereas (at 0.125 mg/kg dose) it decreased L-Glu and L-Asp in the DS. The L-Glu was decreased, at 0.125 mg/kg, only in the VS of NRB rats. The DAT levels were decreased with the 0.125 mg/kg dose (in the PFC), and increased with the 0.250 mg/kg dose (in the VS), significantly for NHE rats. The basal NMDAR1 level was higher in the PFC of NHE than NRB rats; LP-211 treatment (at 0.125 mg/kg dose) decreased NMDAR1 in the VS of NRB rats. This study represents a starting point about the impact of developmental 5-HT7-R activation on neuro-physiology of attentive processes, executive functions and their neural substrates. PMID:24709857

  9. Prepuberal Stimulation of 5-HT7-R by LP-211 in a Rat Model of Hyper-Activity and Attention-Deficit: Permanent Effects on Attention, Brain Amino Acids and Synaptic Markers in the Fronto-Striatal Interface

    PubMed Central

    Treno, Concetta; Gironi Carnevale, Ugo A.; Arra, Claudio; Nieddu, Maria; Pagano, Cristina; Illiano, Placido; Barbato, Fabiana; Carboni, Ezio; Laviola, Giovanni; Lacivita, Enza; Leopoldo, Marcello; Adriani, Walter; Sadile, Adolfo G.

    2014-01-01

    The cross-talk at the prefronto-striatal interface involves excitatory amino acids, different receptors, transducers and modulators. We investigated long-term effects of a prepuberal, subchronic 5-HT7-R agonist (LP-211) on adult behaviour, amino acids and synaptic markers in a model for Attention-Deficit/Hyperactivity Disorder (ADHD). Naples High Excitability rats (NHE) and their Random Bred controls (NRB) were daily treated with LP-211 in the 5th and 6th postnatal week. One month after treatment, these rats were tested for indices of activity, non selective (NSA), selective spatial attention (SSA) and emotionality. The quantity of L-Glutamate (L-Glu), L-Aspartate (L-Asp) and L-Leucine (L-Leu), dopamine transporter (DAT), NMDAR1 subunit and CAMKIIα, were assessed in prefrontal cortex (PFC), dorsal (DS) and ventral striatum (VS), for their role in synaptic transmission, neural plasticity and information processing. Prepuberal LP-211 (at lower dose) reduced horizontal activity and (at higher dose) increased SSA, only for NHE but not in NRB rats. Prepuberal LP-211 increased, in NHE rats, L-Glu in the PFC and L-Asp in the VS (at 0.250 mg/kg dose), whereas (at 0.125 mg/kg dose) it decreased L-Glu and L-Asp in the DS. The L-Glu was decreased, at 0.125 mg/kg, only in the VS of NRB rats. The DAT levels were decreased with the 0.125 mg/kg dose (in the PFC), and increased with the 0.250 mg/kg dose (in the VS), significantly for NHE rats. The basal NMDAR1 level was higher in the PFC of NHE than NRB rats; LP-211 treatment (at 0.125 mg/kg dose) decreased NMDAR1 in the VS of NRB rats. This study represents a starting point about the impact of developmental 5-HT7-R activation on neuro-physiology of attentive processes, executive functions and their neural substrates. PMID:24709857

  10. Energy confinement in tokamaks

    SciTech Connect

    Sugihara, M.; Singer, C.

    1986-08-01

    A straightforward generalization is made of the ohmic heating energy confinement scalings of Pfeiffer and Waltz and Blackwell et. al. The resulting model is systematically calibrated to published data from limiter tokamaks with ohmic, electron cyclotron, and neutral beam heating. With considerably fewer explicitly adjustable free parameters, this model appears to give a better fit to the available data for limiter discharges than the combined ohmic/auxiliary heating model of Goldston.

  11. Multi-Step Protocol for Automatic Evaluation of Docking Results Based on Machine Learning Methods--A Case Study of Serotonin Receptors 5-HT(6) and 5-HT(7).

    PubMed

    Smusz, Sabina; Mordalski, Stefan; Witek, Jagna; Rataj, Krzysztof; Kafel, Rafał; Bojarski, Andrzej J

    2015-04-27

    Molecular docking, despite its undeniable usefulness in computer-aided drug design protocols and the increasing sophistication of tools used in the prediction of ligand-protein interaction energies, is still connected with a problem of effective results analysis. In this study, a novel protocol for the automatic evaluation of numerous docking results is presented, being a combination of Structural Interaction Fingerprints and Spectrophores descriptors, machine-learning techniques, and multi-step results analysis. Such an approach takes into consideration the performance of a particular learning algorithm (five machine learning methods were applied), the performance of the docking algorithm itself, the variety of conformations returned from the docking experiment, and the receptor structure (homology models were constructed on five different templates). Evaluation using compounds active toward 5-HT6 and 5-HT7 receptors, as well as additional analysis carried out for beta-2 adrenergic receptor ligands, proved that the methodology is a viable tool for supporting virtual screening protocols, enabling proper discrimination between active and inactive compounds. PMID:25806997

  12. Polarization spectroscopy of tokamak plasmas

    SciTech Connect

    Wroblewski, D.

    1991-09-01

    Measurements of polarization of spectral lines emitted by tokamak plasmas provide information about the plasma internal magnetic field and the current density profile. The methods of polarization spectroscopy, as applied to the tokamak diagnostic, are reviewed with emphasis on the polarimetry of motional Stark effect in hydrogenic neutral beam emissions. 25 refs., 7 figs.

  13. The tokamak as a neutron source

    SciTech Connect

    Hendel, H.W.; Jassby, D.L.

    1989-11-01

    This paper describes the tokamak in its role as a neutron source, with emphasis on experimental results for D-D neutron production. The sections summarize tokamak operation, sources of fusion and non-fusion neutrons, principal neutron detection methods and their calibration, neutron energy spectra and fluxes outside the tokamak plasma chamber, history of neutron production in tokamaks, neutron emission and fusion power gain from JET and TFTR (the largest present-day tokamaks), and D-T neutron production from burnup of D-D tritons. This paper also discusses the prospects for future tokamak neutron production and potential applications of tokamak neutron sources. 100 refs., 16 figs., 4 tabs.

  14. Development of high-speed and wide-angle visible observation diagnostics on Experimental Advanced Superconducting Tokamak using catadioptric optics.

    PubMed

    Yang, J H; Yang, X F; Hu, L Q; Zang, Q; Han, X F; Shao, C Q; Sun, T F; Chen, H; Wang, T F; Li, F J; Hu, A L

    2013-08-01

    A new wide-angle endoscope for visible light observation on the Experimental Advanced Superconducting Tokamak (EAST) has been recently developed. The head section of the optical system is based on a mirror reflection design that is similar to the International Thermonuclear Experimental Reactor-like wide-angle observation diagnostic on the Joint European Torus. However, the optical system design has been simplified and improved. As a result, the global transmittance of the system is as high as 79.6% in the wavelength range from 380 to 780 nm, and the spatial resolution is <5 mm for the full depth of field (4000 mm). The optical system also has a large relative aperture (1:2.4) and can be applied in high-speed camera diagnostics. As an important diagnostic tool, the optical system has been installed on the HT-7 (Hefei Tokamak-7) for its final experimental campaign, and the experiments confirmed that it can be applied to the investigation of transient processes in plasma, such as ELMy eruptions in H-mode, on EAST. PMID:24007102

  15. Development of high-speed and wide-angle visible observation diagnostics on Experimental Advanced Superconducting Tokamak using catadioptric optics

    SciTech Connect

    Yang, J. H.; Hu, L. Q.; Zang, Q.; Han, X. F.; Shao, C. Q.; Sun, T. F.; Chen, H.; Wang, T. F.; Li, F. J.; Hu, A. L.; Yang, X. F.

    2013-08-15

    A new wide-angle endoscope for visible light observation on the Experimental Advanced Superconducting Tokamak (EAST) has been recently developed. The head section of the optical system is based on a mirror reflection design that is similar to the International Thermonuclear Experimental Reactor-like wide-angle observation diagnostic on the Joint European Torus. However, the optical system design has been simplified and improved. As a result, the global transmittance of the system is as high as 79.6% in the wavelength range from 380 to 780 nm, and the spatial resolution is <5 mm for the full depth of field (4000 mm). The optical system also has a large relative aperture (1:2.4) and can be applied in high-speed camera diagnostics. As an important diagnostic tool, the optical system has been installed on the HT-7 (Hefei Tokamak-7) for its final experimental campaign, and the experiments confirmed that it can be applied to the investigation of transient processes in plasma, such as ELMy eruptions in H-mode, on EAST.

  16. Dust Measurements in Tokamaks

    SciTech Connect

    Rudakov, D; Yu, J; Boedo, J; Hollmann, E; Krasheninnikov, S; Moyer, R; Muller, S; Yu, A; Rosenberg, M; Smirnov, R; West, W; Boivin, R; Bray, B; Brooks, N; Hyatt, A; Wong, C; Fenstermacher, M; Groth, M; Lasnier, C; McLean, A; Stangeby, P; Ratynskaia, S; Roquemore, A; Skinner, C; Solomon, W M

    2008-04-23

    Dust production and accumulation impose safety and operational concerns for ITER. Diagnostics to monitor dust levels in the plasma as well as in-vessel dust inventory are currently being tested in a few tokamaks. Dust accumulation in ITER is likely to occur in hidden areas, e.g. between tiles and under divertor baffles. A novel electrostatic dust detector for monitoring dust in these regions has been developed and tested at PPPL. In DIII-D tokamak dust diagnostics include Mie scattering from Nd:YAG lasers, visible imaging, and spectroscopy. Laser scattering resolves size of particles between 0.16-1.6 {micro}m in diameter; the total dust content in the edge plasmas and trends in the dust production rates within this size range have been established. Individual dust particles are observed by visible imaging using fast-framing cameras, detecting dust particles of a few microns in diameter and larger. Dust velocities and trajectories can be determined in 2D with a single camera or 3D using multiple cameras, but determination of particle size is problematic. In order to calibrate diagnostics and benchmark dust dynamics modeling, pre-characterized carbon dust has been injected into the lower divertor of DIII-D. Injected dust is seen by cameras, and spectroscopic diagnostics observe an increase of carbon atomic, C2 dimer, and thermal continuum emissions from the injected dust. The latter observation can be used in the design of novel dust survey diagnostics.

  17. ITER tokamak device

    NASA Astrophysics Data System (ADS)

    Doggett, J.; Salpietro, E.; Shatalov, G.

    1991-07-01

    The results of the Conceptual Design Activities for the International Thermonuclear Experimental Reactor (ITER) are summarized. These activities, carried out between April 1988 and December 1990, produced a consistent set of technical characteristics and preliminary plans for co-ordinated research and development support of ITER, a conceptual design, a description of design requirements and a preliminary construction schedule and cost estimate. After a description of the design basis, an overview is given of the tokamak device, its auxiliary systems, facility and maintenance. The interrelation and integration of the various subsystems that form the ITER tokamak concept are discussed. The 16 ITER equatorial port allocations, used for nuclear testing, diagnostics, fueling, maintenance, and heating and current drive, are given, as well as a layout of the reactor building. Finally, brief descriptions are given of the major ITER sub-systems, i.e., (1) magnet systems (toroidal and poloidal field coils and cryogenic systems), (2) containment structures (vacuum and cryostat vessels, machine gravity supports, attaching locks, passive loops and active coils), (3) first wall, (4) divertor plate (design and materials, performance and lifetime, a.o.), (5) blanket/shield system, (6) maintenance equipment, (7) current drive and heating, (8) fuel cycle system, and (9) diagnostics.

  18. Sawtooth oscillation in tokamaks

    SciTech Connect

    Park, W.; Monticello, D.A.

    1989-03-01

    A three-dimensional nonlinear toroidal full MHD code, MH3D, has been used to study sawtooth oscillations in tokamaks. The profile evolution during the sawtooth crash phase compares well with experiment, but only if neoclassical resistivity is used in the rise phase. (Classical resistivity has been used in most of the previous theoretical sawtooth studies.) With neoclassical resistivity, the q value at the axis drops from 1 to about 0.8 before the crash phase, and then resets to 1 through a Kadomtsev-type complete reconnection process. This ..delta..q/sub 0/ approx. = 0.2 is much larger than ..delta..q/sub o/ approx. = 0.01, which is obtained if classical resistivity is used. The current profile is strongly peaked at the axis with a flat region around the singular surface, and is similar to the Textor profile. To understand this behavior, approximate formulas for the time behavior of current and q values are derived. A functional dependence of sawtooth period scaling is also derived. A semi-empirical scaling is found which fits the experimental data from various tokamaks. Some evidence is presented which indicates that the fast crash time is due to enhanced effective resistivity inside the singular current sheet, generated by, e.g., microinstability and electron parallel viscosity with stochastic fields at the x-point. 16 refs., 5 figs.

  19. Causes of major tokamak disruptions

    SciTech Connect

    White, R.B.; Monticello, D.A.

    1980-07-01

    The nonlinear saturation theory of the tearing mode is used to examine the necessary conditions for the occurrence of a major tokamak disruption. The results are compared with full three-dimensional numerical simulations, and with experimental data.

  20. The ARIES tokamak reactor study

    SciTech Connect

    Not Available

    1989-10-01

    The ARIES study is a community effort to develop several visions of tokamaks as fusion power reactors. The aims are to determine the potential economics, safety, and environmental features of a range of possible tokamak reactors, and to identify physics and technology areas with the highest leverage for achieving the best tokamak reactor. Three ARIES visions are planned, each having a different degree of extrapolation from the present data base in physics and technology. The ARIES-I design assumes a minimum extrapolation from current tokamak physics (e.g., 1st stability) and incorporates technological advances that can be available in the next 20 to 30 years. ARIES-II is a DT-burning tokamak which would operate at a higher beta in the 2nd MHD stability regime. It employs both potential advances in the physics and expected advances in technology and engineering. ARIES-II will examine the potential of the tokamak and the D{sup 3}He fuel cycle. This report is a collection of 14 papers on the results of the ARIES study which were presented at the IEEE 13th Symposium on Fusion Engineering (October 2-6, 1989, Knoxville, TN). This collection describes the ARIES research effort, with emphasis on the ARIES-I design, summarizing the major results, the key technical issues, and the central conclusions.

  1. Moving Divertor Plates in a Tokamak

    SciTech Connect

    S.J. Zweben, H. Zhang

    2009-02-12

    Moving divertor plates could help solve some of the problems of the tokamak divertor through mechanical ingenuity rather than plasma physics. These plates would be passively heated on each pass through the tokamak and cooled and reprocessed outside the tokamak. There are many design options using varying plate shapes, orientations, motions, coatings, and compositions.

  2. Status of tokamak experiments

    SciTech Connect

    Wolf, G.H.

    1996-03-01

    Plasma-wall interaction, heat removal and ash exhaust have emerged as the dominant problems still to be solved in order to achieve ignition and - even more difficult - to maintain a state of self-sustained thermo-nuclear burn. This is of particular delicacy, since those operational regimes which yield the best energy confinement correspond to an even better particle confinement and confinement of impurities, which then tend to accumulate in the plasma core and to result in disruption or degradation of the tokamak discharge. Therefore, plasma-wall interaction, heat removal and particle exhaust will determine not only the structure and configuration of the plasma edge region, of the wall system and of the materials facing the plasma, but also the final choice of useful confinement regimes. Moreover, the potential effect of powerful {alpha}-particle heating on plasma stability and confinement has to be kept below critical values. For the latter requirement, a final answer can only be obtained in an ITER-type device where ignition and burn will become accessible. 72 refs., 12 figs.

  3. Resistive instabilities in tokamaks

    SciTech Connect

    Rutherford, P.H.

    1985-10-01

    Low-m tearing modes constitute the dominant instability problem in present-day tokamaks. In this lecture, the stability criteria for representative current profiles with q(0)-values slightly less than unit are reviewed; ''sawtooth'' reconnection to q(0)-values just at, or slightly exceeding, unity is generally destabilizing to the m = 2, n = 1 and m = 3, n = 2 modes, and severely limits the range of stable profile shapes. Feedback stabilization of m greater than or equal to 2 modes by rf heating or current drive, applied locally at the magnetic islands, appears feasible; feedback by island current drive is much more efficient, in terms of the radio-frequency power required, then feedback by island heating. Feedback stabilization of the m = 1 mode - although yielding particularly beneficial effects for resistive-tearing and high-beta stability by allowing q(0)-values substantially below unity - is more problematical, unless the m = 1 ideal-MHD mode can be made positively stable by strong triangular shaping of the central flux surfaces. Feedback techniques require a detectable, rotating MHD-like signal; the slowing of mode rotation - or the excitation of non-rotating modes - by an imperfectly conducting wall is also discussed.

  4. Tokamak coordinate conventions: COCOS

    NASA Astrophysics Data System (ADS)

    Sauter, O.; Medvedev, S. Yu.

    2013-02-01

    Dealing with electromagnetic fields, in particular current and related magnetic fields, yields "natural" physical vector relations in 3-D. However, when it comes to choosing local coordinate systems, the "usual" right-handed systems are not necessarily the best choices, which means that there are several options being chosen. In the magnetic fusion community such a difficulty exists for the choices of the cylindrical and of the toroidal coordinate systems. In addition many codes depend on knowledge of an equilibrium. In particular, the Grad-Shafranov axisymmetric equilibrium solution for tokamak plasmas, ψ, does not depend on the sign of the plasma current Ip nor that of the magnetic field B0. This often results in ill-defined conventions. Moreover the sign, amplitude and offset of ψ are of less importance, since the free sources in the equation depend on the normalized radial coordinate. The signs of the free sources, dp/dψ and dF2/dψ (p being the pressure, ψ the poloidal magnetic flux and F=RBφ), must be consistent to generate the current density profile. For example, RF and CD calculations (Radio Frequency heating and Current Drive) require an exact sign convention in order to calculate a co- or counter-CD component. It is shown that there are over 16 different coordinate conventions. This paper proposes a unique identifier, the COCOS convention, to distinguish between the 16 most-commonly used options. Given the present worldwide efforts towards code integration, the proposed new index COCOS defining uniquely the COordinate COnventionS required as input by a given code or module is particularly useful. As codes use different conventions, it is useful to allow different sign conventions for equilibrium code input and output, equilibrium being at the core of any calculations in magnetic fusion. Additionally, given two different COCOS conventions, it becomes simple to transform between them. The relevant transformations are described in detail.

  5. Tokamak and RFP ignition requirements

    SciTech Connect

    Werley, K.A.

    1991-01-01

    A plasma model is applied to calculate numerically transport- confinement (n{tau}{sub E}) requirements and steady-state operation tokamak. The CIT tokamak and RFP ignition conditions are examined. Physics differences between RFP and tokamaks, and their consequences for a DT ignition machine, are discussed. The ignition RFP, compared to a tokamak, has many physics advantages, including ohmic heating to ignition (no need for auxiliary heating systems), higher beta, low ignition current, less sensitivity of ignition requirements to impurity effects, no hard disruptions (associated with beta or density limits), and successful operation with high radiation fractions (f{sub RAD} {approximately} 0.95). These physics advantages, coupled with important engineering advantages associated with lower external magnetic fields, larger aspect ratios, and smaller plasma cross sections translate into significant cost reductions for both ignition and power reactor. The primary drawback of the RFP is the uncertainty that the present confinement scaling will extrapolate to reactor regimes. The 4-MA ZTH was expected to extend the n{tau}{sub E} transport scaling data three order of magnitude above ZT-40M results, and if the present scaling held, to achieve a DT-equivalent scientific energy breakeven, Q=1. A basecase RFP ignition point is identified with a plasma current of 8.1 MA and no auxiliary heating. 16 refs., 4 figs., 1 tab.

  6. Prospects for Tokamak Fusion Reactors

    SciTech Connect

    Sheffield, J.; Galambos, J.

    1995-04-01

    This paper first reviews briefly the status and plans for research in magnetic fusion energy and discusses the prospects for the tokamak magnetic configuration to be the basis for a fusion power plant. Good progress has been made in achieving fusion reactor-level, deuterium-tritium (D-T) plasmas with the production of significant fusion power in the Joint European Torus (up to 2 MW) and the Tokamak Fusion Test Reactor (up to 10 MW) tokamaks. Advances on the technologies of heating, fueling, diagnostics, and materials supported these achievements. The successes have led to the initiation of the design phases of two tokamaks, the International Thermonuclear Experimental Reactor (ITER) and the US Toroidal Physics Experiment (TPX). ITER will demonstrate the controlled ignition and extended bum of D-T plasmas with steady state as an ultimate goal. ITER will further demonstrate technologies essential to a power plant in an integrated system and perform integrated testing of the high heat flux and nuclear components required to use fusion energy for practical purposes. TPX will complement ITER by testing advanced modes of steady-state plasma operation that, coupled with the developments in ITER, will lead to an optimized demonstration power plant.

  7. Bootstrapped tokamak with oscillating field current drive

    SciTech Connect

    Weening, R.H. )

    1993-07-01

    A magnetic helicity conserving mean-field Ohm's law is used to study bootstrapped tokamaks with oscillating field current drive. The Ohm's law leads to the conclusion that the tokamak bootstrap effect can convert the largely alternating current of oscillating field current drive into a direct toroidal plasma current. This plasma current rectification is due to the intrinsically nonlinear nature of the tokamak bootstrap effect, and suggests that it may be possible to maintain the toroidal current of a tokamak reactor by supplementing the bootstrap current with oscillating field current drive. Steady-state tokamak fusion reactors operating with oscillating field current drive could provide an alternative to tokamak reactors operating with external current drive.

  8. Extraction of large-scale coherent structure from plasma turbulence using rake probe and wavelet analysis in a tokamak

    SciTech Connect

    Xu, G. S.; Wan, B. N.; Zhang, W.

    2006-06-15

    In fusion plasmas, intermittently occurring large-scale coherent structures in electrostatic turbulence sometimes contribute more than 50% of total transport, so the investigation on these coherent structures is important for understanding plasma confinement. New experimental techniques are required to extract these coherent structures from fluctuating signals. In this work a 12-tip poloidal rake probe was used on the HT-7 superconducting tokamak to measure plasma turbulence in the plasma edge region. Several signal analysis methods based on a biorthogonal wavelet were developed and applied to the probe data. Since the structure of the selected wavelet is every similar to that of the turbulence wave packet, information about large-scale coherent structures can be selectively extracted from the ambient turbulence. The spatiotemporal patterns of the large-scale coherent structures were reconstructed using the selected wavelets as well as those of small-scale details. These wavelet-based techniques can be applied to all kinds of plasma fluctuation diagnostics, so they possibly present a new opportunity for uncovering the mechanism underlying plasma turbulent transport.

  9. Microwave Tokamak Experiment: Overview and status

    SciTech Connect

    Not Available

    1990-05-01

    The Microwave Tokamak Experiment, now under construction at the Laboratory, will use microwave heating from a free-electron laser. The intense microwave pulses will be injected into the tokamak to realize several goals, including a demonstration of the effects of localized heat deposition within magnetically confined plasma, a better understanding of energy confinement in tokamaks, and use of the new free-electron laser technology for plasma heating. 3 figs., 3 tabs.

  10. Comprehensive numerical modelling of tokamaks

    SciTech Connect

    Cohen, R.H.; Cohen, B.I.; Dubois, P.F.

    1991-01-03

    We outline a plan for the development of a comprehensive numerical model of tokamaks. The model would consist of a suite of independent, communicating packages describing the various aspects of tokamak performance (core and edge transport coefficients and profiles, heating, fueling, magnetic configuration, etc.) as well as extensive diagnostics. These codes, which may run on different computers, would be flexibly linked by a user-friendly shell which would allow run-time specification of packages and generation of pre- and post-processing functions, including workstation-based visualization of output. One package in particular, the calculation of core transport coefficients via gyrokinetic particle simulation, will become practical on the scale required for comprehensive modelling only with the advent of teraFLOP computers. Incremental effort at LLNL would be focused on gyrokinetic simulation and development of the shell.

  11. Burn Control Mechanisms in Tokamaks

    NASA Astrophysics Data System (ADS)

    Hill, Maxwell; Stacey, Weston

    2013-10-01

    Burn control and passive safety in accident scenarios will be an important design consideration in future tokamaks, especially those used as a neutron source for fusion-fission hybrid reactors, such as the Subcritical Advanced Burner Reactor (SABR) concept. At Georgia Tech, we are developing a new burning plasma dynamics code to investigate passive safety mechanisms that could prevent power excursions in tokamak reactors. This code solves the coupled set of balance equations governing burning plasmas in conjunction with a two-point SOL-divertor model. Predictions have been benchmarked against data from DIII-D. We are examining several potential negative feedback mechanisms to limit power excursions: i) ion-orbit loss, ii) thermal instabilities, iii) the degradation of alpha-particle confinement resulting from ripples in the toroidal field, iv) modifications to the radial current profile, v) ``divertor choking'' and vi) Type 1 ELMs.

  12. MHD stability of tokamak plasmas

    SciTech Connect

    Chance, M.S. Sun, Y.C.; Jardin, S.C.; Kessel, C.E.; Okabayashi, M.

    1992-08-01

    This paper will give an overview of the some of the methods which are used to simulate the ideal MHD properties of tokamak plasmas. A great deal of the research in this field is necessarily numerical and the substantial progress made during the past several years has roughly paralleled the continuing availability of more advanced supercomputers. These have become essential to accurately model the complex configurations necessary for achieving MHD stable reactor grade conditions. Appropriate tokamak MHD equilibria will be described. Then the stability properties is discussed in some detail, emphasizing the difficulties of obtaining stable high {beta} discharges in plasmas in which the current is mainly ohmically driven and thus demonstrating the need for tailoring the current and pressure profiles of the plasma away from the ohmic state. The outline of this paper will roughly follow the physics development to attain the second region of stability in the PBX-M device at The Princeton Plasmas Physics Laboratory.

  13. Density limit disruptions in tokamaks

    NASA Astrophysics Data System (ADS)

    Kleva, Robert G.; Drake, J. F.

    1991-02-01

    Magnetohydrodynamic simulations are presented which reproduce the rapid drop in the central temperature observed during density limit disruptions in tokamaks. The loss of central confinement is triggered by edge radiation which destabilizes a q=1 kink mode. A bubble of cold plasma is injected from the edge into the center by the q=1 kink. This bubble bears a striking resemblance to the cold plasma that is observed to move from the edge into the center during density limit disruptions on the JET tokamak [Plasma Physics and Controlled Nuclear Fusion Research 1986 (IAEA, Vienna, 1987), Vol. 1, p. 433], initiating the loss of central confinement. The bubble profile produced by the q=1 kink is unstable to a broad spectrum of modes which progressively reduce the magnetic shear between the q=2 surface and the center. The q=2 mode then grows across the center, broadening the current and throwing the hot plasma to the wall.

  14. Gyrosheath near the tokamak edge

    SciTech Connect

    Hazeltine, R.D.; Xiao, H.; Valanju, P.M.

    1993-03-01

    A new model for the structure of the radial electric field profile in the edge during the H-mode is proposed. Charge separation caused by the difference between electron and ion gyromotion, or more importantly in a tokamak, the banana motion (halo effect) can self-consistently produce an electric dipole moment that causes the sheared radial electric field. The calculated results based on the model are consistent with D-III D and TEXTOR experimental results.

  15. Neoclassical magnetic microislands in tokamaks

    SciTech Connect

    Kovalishen, E.A.; Mikhailovskii, A.B.; Botov, P.V.; Shirokov, M.S.; Konovalov, S.V.; Tsypin, V.S.; Galvao, R.M.O.

    2005-09-15

    Possibility of existence of neoclassical magnetic microislands (island width smaller than the ion Larmor radius) in a tokamak in the banana regime is shown. The rotation frequency of such islands is found. It is shown that for the case of positive electron temperature gradient, the bootstrap current destabilizes the microislands while the polarization current leads to their stabilization. Maximally possible neoclassical microisland width is estimated.

  16. Magnetic island formation in tokamaks

    SciTech Connect

    Yoshikawa, S.

    1989-04-01

    The size of a magnetic island created by a perturbing helical field in a tokamak is estimated. A helical equilibrium of a current- carrying plasma is found in a helical coordinate and the helically flowing current in the cylinder that borders the plasma is calculated. From that solution, it is concluded that the helical perturbation of /approximately/10/sup /minus/4/ of the total plasma current is sufficient to cause an island width of approximately 5% of the plasma radius. 6 refs.

  17. Magnetic confinement experiment. I: Tokamaks

    SciTech Connect

    Goldston, R.J.

    1995-08-01

    Reports were presented at this conference of important advances in all the key areas of experimental tokamak physics: Core Plasma Physics, Divertor and Edge Physics, Heating and Current Drive, and Tokamak Concept Optimization. In the area of Core Plasma Physics, the biggest news was certainly the production of 9.2 MW of fusion power in the Tokamak Fusion Test Reactor, and the observation of unexpectedly favorable performance in DT plasmas. There were also very important advances in the performance of ELM-free H- (and VH-) mode plasmas and in quasi-steady-state ELM`y operation in JT-60U, JET, and DIII-D. In all three devices ELM-free H-modes achieved nT{tau}`s {approximately} 2.5x greater than ELM`ing H-modes, but had not been sustained in quasi-steady-state. Important progress has been made on the understanding of the physical mechanism of the H-mode in DIII-D, and on the operating range in density for the H-mode in Compass and other devices.

  18. Numerical tokamak turbulence project (OFES grand challenge)

    SciTech Connect

    Beer, M; Cohen, B I; Crotinger, J; Dawson, J; Decyk, V; Dimits, A M; Dorland, W D; Hammett, G W; Kerbel, G D; Leboeuf, J N; Lee, W W; Lin, Z; Nevins, W M; Reynders, J; Shumaker, D E; Smith, S; Sydora, R; Waltz, R E; Williams, T

    1999-08-27

    The primary research objective of the Numerical Tokamak Turbulence Project (NTTP) is to develop a predictive ability in modeling turbulent transport due to drift-type instabilities in the core of tokamak fusion experiments, through the use of three-dimensional kinetic and fluid simulations and the derivation of reduced models.

  19. Steady State Tokamak Equilibria without Current Drive

    SciTech Connect

    Shaing, K.C.; Aydemir, A.Y.; Lin-Liu, Y.R.; Miller, R.L.

    1997-11-01

    Steady state tokamak equilibria without current drive are found. This is made possible by including the potato bootstrap current close to the magnetic axis. Tokamaks with this class of equilibria do not need seed current or current drive, and are intrinsically steady state. {copyright} {ital 1997} {ital The American Physical Society}

  20. Physics of compact ignition tokamak designs

    SciTech Connect

    Singer, C.E.; Ku, L.P.; Bateman, G.; Seidl, F.; Sugihara, M.

    1986-03-01

    Models for predicting plasma performance in compact ignition experiments are constructed on the basis of theoretical and empirical constraints and data from tokamak experiments. Emphasis is placed on finding transport and confinement models which reproduce results of both ohmically and auxiliary heated tokamak data. Illustrations of the application of the models to compact ignition designs are given.

  1. Advanced tokamak research on the DIII-D tokamak

    SciTech Connect

    Chan, V.S.

    1994-01-01

    The objective of the planned research in advanced tokamak development on DIII-D at General Atomics, San Diego, USA. is to establish improved tokamak operation through significant improvements in the stability factor, confinement quality, and bootstrap current fraction using localized radio frequency (rf) current profile control, rf and neutral beam heating for pressure profile control, as well as control of plasma rotation and optimization of the plasma boundary conditions. Recent research results in H-mode confinement, modifications of current profiles to achieve higher confinement and higher {beta}, a new regime of improved confinement (VH-mode), and rf noninductive current drive are encouraging. In this talk, arguments will be presented supporting the need for improved performance in tokamak reactors. Experimentally observed advanced performance regimes on DIII-D will be discussed. Confinement improvement up to H = 4, where H is the ratio of energy confinement time to the ITER89-P scaling H{triple_bond} {Tau}{sub E}/{Tau}{sub E-ITER89-P}, has been achieved. In other discharges {beta}{sub N} = {beta}/(I/aB),[%-m{center_dot}{Tau}/MA] {approx_gt} 6 has been obtained. These values have so far been achieved transiently and independently. Techniques, will be described which can extend the high performance to quasi-steady-state and sustain the high H and {beta}{sub N} values simultaneously. Two high performance regimes, one in first stable regime and the other in second stable regime, have been simulated br self-consistently evolving a magnetohydrodynamic (MHD) equilibrium-transport code. Finally, experimental program plans and outstanding important physics issues will be discussed.

  2. Linear optimal control of tokamak fusion devices

    SciTech Connect

    Kessel, C.E.; Firestone, M.A.; Conn, R.W.

    1989-05-01

    The control of plasma position, shape and current in a tokamak fusion reactor is examined using linear optimal control. These advanced tokamaks are characterized by non up-down symmetric coils and structure, thick structure surrounding the plasma, eddy currents, shaped plasmas, superconducting coils, vertically unstable plasmas, and hybrid function coils providing ohmic heating, vertical field, radial field, and shaping field. Models of the electromagnetic environment in a tokamak are derived and used to construct control gains that are tested in nonlinear simulations with initial perturbations. The issues of applying linear optimal control to advanced tokamaks are addressed, including complex equilibrium control, choice of cost functional weights, the coil voltage limit, discrete control, and order reduction. Results indicate that the linear optimal control is a feasible technique for controlling advanced tokamaks where the more common classical control will be severely strained or will not work. 28 refs., 13 figs.

  3. Transport equations in tokamak plasmas

    SciTech Connect

    Callen, J. D.; Hegna, C. C.; Cole, A. J.

    2010-05-15

    Tokamak plasma transport equations are usually obtained by flux surface averaging the collisional Braginskii equations. However, tokamak plasmas are not in collisional regimes. Also, ad hoc terms are added for neoclassical effects on the parallel Ohm's law, fluctuation-induced transport, heating, current-drive and flow sources and sinks, small magnetic field nonaxisymmetries, magnetic field transients, etc. A set of self-consistent second order in gyroradius fluid-moment-based transport equations for nearly axisymmetric tokamak plasmas has been developed using a kinetic-based approach. The derivation uses neoclassical-based parallel viscous force closures, and includes all the effects noted above. Plasma processes on successive time scales and constraints they impose are considered sequentially: compressional Alfven waves (Grad-Shafranov equilibrium, ion radial force balance), sound waves (pressure constant along field lines, incompressible flows within a flux surface), and collisions (electrons, parallel Ohm's law; ions, damping of poloidal flow). Radial particle fluxes are driven by the many second order in gyroradius toroidal angular torques on a plasma species: seven ambipolar collision-based ones (classical, neoclassical, etc.) and eight nonambipolar ones (fluctuation-induced, polarization flows from toroidal rotation transients, etc.). The plasma toroidal rotation equation results from setting to zero the net radial current induced by the nonambipolar fluxes. The radial particle flux consists of the collision-based intrinsically ambipolar fluxes plus the nonambipolar fluxes evaluated at the ambipolarity-enforcing toroidal plasma rotation (radial electric field). The energy transport equations do not involve an ambipolar constraint and hence are more directly obtained. The 'mean field' effects of microturbulence on the parallel Ohm's law, poloidal ion flow, particle fluxes, and toroidal momentum and energy transport are all included self-consistently. The

  4. The Microwave Tokamak Experiment (MTX)

    SciTech Connect

    Thomassen, K.I.; Cohen, B.I.; Hooper, E.B.; Lang, D.D.; Nevins, W.M.

    1987-10-02

    A new experimental facility is being assembled at the Lawrence Livermore National Laboratory (LLNL) for studying microwave propagation and absorption in high density plasmas. A unique feature of the facility is the free electron laser (FEL) used to generate high peak power microwaves at 250 GHz, at a repetition rate so as to produce up to 2 MW of average power for up to 30 s. Called the Microwave Tokamak Experiment (MTX), the facility will be used for studies of plasma heating, current drive, and confinement.

  5. Breakdown in the pretext tokamak

    SciTech Connect

    Benesch, J.F.

    1981-06-01

    Data are presented on the application of ion cyclotron resonance RF power to preionization in tokamaks. We applied 0.3-3 kW at 12 MHz to hydrogen and obtained a visible discharge, but found no scaling of breakdown voltage with any parameter we were able to vary. A possible explanation for this, which implies that higher RF power would have been much more effective, is discussed. Finally, we present our investigation of the dV/dt dependence of breakdown voltage in PRETEXT, a phenomenon also seen in JFT-2. The breakdown is discussed in terms of the physics of Townsend discharges.

  6. Predictive Modeling of Tokamak Configurations*

    NASA Astrophysics Data System (ADS)

    Casper, T. A.; Lodestro, L. L.; Pearlstein, L. D.; Bulmer, R. H.; Jong, R. A.; Kaiser, T. B.; Moller, J. M.

    2001-10-01

    The Corsica code provides comprehensive toroidal plasma simulation and design capabilities with current applications [1] to tokamak, reversed field pinch (RFP) and spheromak configurations. It calculates fixed and free boundary equilibria coupled to Ohm's law, sources, transport models and MHD stability modules. We are exploring operations scenarios for both the DIII-D and KSTAR tokamaks. We will present simulations of the effects of electron cyclotron heating (ECH) and current drive (ECCD) relevant to the Quiescent Double Barrier (QDB) regime on DIII-D exploring long pulse operation issues. KSTAR simulations using ECH/ECCD in negative central shear configurations explore evolution to steady state while shape evolution studies during current ramp up using a hyper-resistivity model investigate startup scenarios and limitations. Studies of high bootstrap fraction operation stimulated by recent ECH/ECCD experiments on DIIID will also be presented. [1] Pearlstein, L.D., et al, Predictive Modeling of Axisymmetric Toroidal Configurations, 28th EPS Conference on Controlled Fusion and Plasma Physics, Madeira, Portugal, June 18-22, 2001. * Work performed under the auspices of the U.S. Department of Energy by the University of California, Lawrence Livermore National Laboratory under contract No. W-7405-Eng-48.

  7. Superconducting magnet system for the TPX Tokamak

    SciTech Connect

    Hassenzahl, W.V.; Chaplin, M.R.; Heim, J.R.

    1993-09-15

    The Tokamak Physics Experiment (TPX) will be the first Tokamak using superconducting magnets for both the poloidal and toroidal field. It is designed for advanced Tokamak physics experiments in steady-state and long-pulse operation. The TPX superconducting magnets use an advanced cable-in-conduit conductor (CICC) design similar to that developed in support of the International Thermonuclear Experimental Reactor (ITER). The toroidal field magnets provide 4.0 T at 2.25 m with a stored energy of 1.05 GJ. The poloidal field magnets provide 18.0 V-s to ohmically start and control long burns of a 2.0 MA plasma.

  8. OPTIMUM PLASMA STATES FOR NEXT STEP TOKAMAKS

    SciTech Connect

    LIN-LIU,YR; STAMBAUGH,RD

    2002-11-01

    OAK A271 OPTIMUM PLASMA STATES FOR NEXT STEP TOKAMAKS. The dependence of the ideal ballooning {beta} limit on aspect ratio, A, and elongation {kappa} is systematically explored for nearly 100% bootstrap current driven tokamak equilibria in a wide range of the shape parameters (A = 1.2-7.0, {kappa} = 1.5-6.0 with triangularity {delta} = 0.5). The critical {beta}{sub N} is shown to be optimal at {kappa} = 3.0-4.0 for all A studied and increases as A decreases with a dependence close to A{sup -0.5}. The results obtained can be used as a theoretical basis for the choice of optimum aspect ratio and elongation of next step burning plasma tokamaks or tokamak reactors.

  9. Power and particle exhaust in tokamaks

    SciTech Connect

    Stambaugh, R.D.

    1998-01-01

    The status of power and particle exhaust research in tokamaks is reviewed in the light of ITER requirements. There is a sound basis for ITER`s nominal design positions; important directions for further research are identified.

  10. Control of Dust Inventory in Tokamaks

    SciTech Connect

    Rosanvallon, S.; Grisolia, C.; Andrew, P.; Ciattaglia, S.; Pitcher, C. S.; Taylor, N.; Furlan, J.

    2008-09-07

    Particles with sizes ranging from 100 nm to 100 {mu}m are produced in tokamaks by the interaction of the plasma with the first wall materials and divertor. Dust has not yet been of a major concern in existing tokamaks mainly because their quantities are small and these devices are not nuclear facilities. However, in ITER and in future reactors, they could represent operational and potential safety issues. The aim of this paper is thus to describe the dust creation processes in the tokamak environment. The diagnostics and removal techniques that are needed to be implemented to measure and minimise the dust inventory are also presented. The integration of these techniques into a tokamak environment is also discussed.

  11. Burn Control Mechanisms in Tokamaks

    NASA Astrophysics Data System (ADS)

    Hill, M. A.; Stacey, W. M.

    2015-11-01

    Burn control and passive safety in accident scenarios will be an important design consideration in future tokamak reactors, in particular fusion-fission hybrid reactors, e.g. the Subcritical Advanced Burner Reactor. We are developing a burning plasma dynamics code to explore various aspects of burn control, with the intent to identify feedback mechanisms that would prevent power excursions. This code solves the coupled set of global density and temperature equations, using scaling relations from experimental fits. Predictions of densities and temperatures have been benchmarked against DIII-D data. We are examining several potential feedback mechanisms to limit power excursions: i) ion-orbit loss, ii) thermal instability density limits, iii) MHD instability limits, iv) the degradation of alpha-particle confinement, v) modifications to the radial current profile, vi) ``divertor choking'' and vii) Type 1 ELMs. Work supported by the US DOE under DE-FG02-00ER54538, DE-FC02-04ER54698.

  12. Dust measurements in tokamaks (invited)

    SciTech Connect

    Rudakov, D. L.; Yu, J. H.; Boedo, J. A.; Hollmann, E. M.; Krasheninnikov, S. I.; Moyer, R. A.; Muller, S. H.; Pigarov, A. Yu.; Rosenberg, M.; Smirnov, R. D.; West, W. P.; Boivin, R. L.; Bray, B. D.; Brooks, N. H.; Hyatt, A. W.; Wong, C. P. C.; Roquemore, A. L.; Skinner, C. H.; Solomon, W. M.; Ratynskaia, S.

    2008-10-15

    Dust production and accumulation present potential safety and operational issues for the ITER. Dust diagnostics can be divided into two groups: diagnostics of dust on surfaces and diagnostics of dust in plasma. Diagnostics from both groups are employed in contemporary tokamaks; new diagnostics suitable for ITER are also being developed and tested. Dust accumulation in ITER is likely to occur in hidden areas, e.g., between tiles and under divertor baffles. A novel electrostatic dust detector for monitoring dust in these regions has been developed and tested at PPPL. In the DIII-D tokamak dust diagnostics include Mie scattering from Nd:YAG lasers, visible imaging, and spectroscopy. Laser scattering is able to resolve particles between 0.16 and 1.6 {mu}m in diameter; using these data the total dust content in the edge plasmas and trends in the dust production rates within this size range have been established. Individual dust particles are observed by visible imaging using fast framing cameras, detecting dust particles of a few microns in diameter and larger. Dust velocities and trajectories can be determined in two-dimension with a single camera or three-dimension using multiple cameras, but determination of particle size is challenging. In order to calibrate diagnostics and benchmark dust dynamics modeling, precharacterized carbon dust has been injected into the lower divertor of DIII-D. Injected dust is seen by cameras, and spectroscopic diagnostics observe an increase in carbon line (CI, CII, C{sub 2} dimer) and thermal continuum emissions from the injected dust. The latter observation can be used in the design of novel dust survey diagnostics.

  13. Plasma Physics Regimes in Tokamaks with Li Walls

    SciTech Connect

    L.E. Zakharo; N.N. Gorelenkov; R.B. White; S.I. Krasheninnikov; G.V. Pereverzev

    2003-08-21

    Low recycling regimes with a plasma limited by a lithium wall surface suggest enhanced stability and energy confinement, both necessary for tokamak reactors. These regimes could make ignition feasible in compact tokamaks. Ignited Spherical Tokamaks (IST), self-sufficient in the bootstrap current, are introduced as a necessary step for development of the physics and technology of power reactors.

  14. Bifurcated helical core equilibrium states in tokamaks

    NASA Astrophysics Data System (ADS)

    Cooper, W. A.; Chapman, I. T.; Schmitz, O.; Turnbull, A. D.; Tobias, B. J.; Lazarus, E. A.; Turco, F.; Lanctot, M. J.; Evans, T. E.; Graves, J. P.; Brunetti, D.; Pfefferlé, D.; Reimerdes, H.; Sauter, O.; Halpern, F. D.; Tran, T. M.; Coda, S.; Duval, B. P.; Labit, B.; Pochelon, A.; Turnyanskiy, M. R.; Lao, L.; Luce, T. C.; Buttery, R.; Ferron, J. R.; Hollmann, E. M.; Petty, C. C.; van Zeeland, M.; Fenstermacher, M. E.; Hanson, J. M.; Lütjens, H.

    2013-07-01

    Tokamaks with weak to moderate reversed central shear in which the minimum inverse rotational transform (safety factor) qmin is in the neighbourhood of unity can trigger bifurcated magnetohydrodynamic equilibrium states, one of which is similar to a saturated ideal internal kink mode. Peaked prescribed pressure profiles reproduce the ‘snake’ structures observed in many tokamaks which has led to a novel explanation of the snake as a bifurcated equilibrium state. Snake equilibrium structures are computed in simulations of the tokamak à configuration variable (TCV), DIII-D and mega amp spherical torus (MAST) tokamaks. The internal helical deformations only weakly modulate the plasma-vacuum interface which is more sensitive to ripple and resonant magnetic perturbations. On the other hand, the external perturbations do not alter the helical core deformation in a significant manner. The confinement of fast particles in MAST simulations deteriorate with the amplitude of the helical core distortion. These three-dimensional bifurcated solutions constitute a paradigm shift that motivates the applications of tools developed for stellarator research in tokamak physics investigations.

  15. Microtearing modes in tokamak discharges

    NASA Astrophysics Data System (ADS)

    Rafiq, T.; Weiland, J.; Kritz, A. H.; Luo, L.; Pankin, A. Y.

    2016-06-01

    Microtearing modes (MTMs) have been identified as a source of significant electron thermal transport in tokamak discharges. In order to describe the evolution of these discharges, it is necessary to improve the prediction of electron thermal transport. This can be accomplished by utilizing a model for transport driven by MTMs in whole device predictive modeling codes. The objective of this paper is to develop the dispersion relation that governs the MTM driven transport. A unified fluid/kinetic approach is used in the development of a nonlinear dispersion relation for MTMs. The derivation includes the effects of electrostatic and magnetic fluctuations, arbitrary electron-ion collisionality, electron temperature and density gradients, magnetic curvature, and the effects associated with the parallel propagation vector. An iterative nonlinear approach is used to calculate the distribution function employed in obtaining the nonlinear parallel current and the nonlinear dispersion relation. The third order nonlinear effects in magnetic fluctuations are included, and the influence of third order effects on a multi-wave system is considered. An envelope equation for the nonlinear microtearing modes in the collision dominant limit is introduced in order to obtain the saturation level. In the limit that the mode amplitude does not vary along the field line, slab geometry, and strong collisionality, the fluid dispersion relation for nonlinear microtearing modes is found to agree with the kinetic dispersion relation.

  16. Ripple induced trapped particle loss in tokamaks

    SciTech Connect

    White, R.B.

    1996-05-01

    The threshold for stochastic transport of high energy trapped particles in a tokamak due to toroidal field ripple is calculated by explicit construction of primary resonances, and a numerical examination of the route to chaos. Critical field ripple amplitude is determined for loss. The expression is given in magnetic coordinates and makes no assumptions regarding shape or up-down symmetry. An algorithm is developed including the effects of prompt axisymmetric orbit loss, ripple trapping, convective banana flow, and stochastic ripple loss, which gives accurate ripple loss predictions for representative Tokamak Fusion Test Reactor and International Thermonuclear Experimental Reactor equilibria. The algorithm is extended to include the effects of collisions and drag, allowing rapid estimation of alpha particle loss in tokamaks.

  17. Global gyrokinetic simulation of tokamak transport

    SciTech Connect

    Furnish, G.; Horton, W.; Kishimoto, Y.; LeBrun, M.J.; Tajima, T. |

    1998-10-01

    A kinetic simulation code based on the gyrokinetic ion dynamics in global general metric (including a tokamak with circular or noncircular cross-section) has been developed. This gyrokinetic simulation is capable of examining the global and semi-global driftwave structures and their associated transport in a tokamak plasma. The authors investigate the property of the ion temperature gradient (ITG) or {eta}{sub i}({eta}{sub i} {equivalent_to} {partial_derivative}{ell}nT{sub i}/{partial_derivative}{ell}n n{sub i}) driven drift waves in a tokamak plasma. The emergent semi-global drift wave modes give rise to thermal transport characterized by the Bohm scaling.

  18. Activation analysis of the compact ignition tokamak

    SciTech Connect

    Selcow, E.C.

    1986-01-01

    The US fusion program has completed the conceptual design of a compact tokamak device that achieves ignition. The high neutron wall loadings associated with this compact deuterium-tritium-burning device indicate that radiation-related issues may be significant considerations in the overall system design. Sufficient shielding will be requied for the radiation protection of both reactor components and occupational personnel. A close-in igloo shield has been designed around the periphery of the tokamak structure to permit personnel access into the test cell after shutdown and limit the total activation of the test cell components. This paper describes the conceptual design of the igloo shield system and discusses the major neutronic concerns related to the design of the Compact Ignition Tokamak.

  19. Electron cyclotron emission diagnostics on KSTAR tokamak

    SciTech Connect

    Jeong, S. H.; Lee, K. D.; Kwon, M.; Kogi, Y.; Kawahata, K.; Nagayama, Y.; Mase, A.

    2010-10-15

    A new electron cyclotron emission (ECE) diagnostics system was installed for the Second Korea Superconducting Tokamak Advanced Research (KSTAR) campaign. The new ECE system consists of an ECE collecting optics system, an overmode circular corrugated waveguide system, and 48 channel heterodyne radiometer with the frequency range of 110-162 GHz. During the 2 T operation of the KSTAR tokamak, the electron temperatures as well as its radial profiles at the high field side were measured and sawtooth phenomena were also observed. We also discuss the effect of a window on in situ calibration.

  20. Tokamak power systems studies, FY 1985

    SciTech Connect

    Baker, C.C.; Brooks, J.N.; Ehst, D.A.; Smith, D.L.; Sze, D.K.

    1985-12-01

    The Tokamak Power System Studies (TPSS) at ANL in FY-1985 were devoted to exploring innovative design concepts which have the potential for making substantial improvements in the tokamak as a commercial power reactor. Major objectives of this work included improved reactor economics, improved environmental and safety features, and the exploration of a wide range of reactor plant outputs with emphasis on reduced plant sizes compared to STARFIRE. The activities concentrated on three areas: plasma engineering, impurity control, and blanket/first wall/shield technology. 205 refs., 125 figs., 107 tabs.

  1. Tokamak Spectroscopy for X-Ray Astronomy

    NASA Technical Reports Server (NTRS)

    Fournier, Kevin B.; Finkenthal, M.; Pacella, D.; May, M. J.; Soukhanovskii, V.; Mattioli, M.; Leigheb, M.; Rice, J. E.

    2000-01-01

    This paper presents the measured x-ray and Extreme Ultraviolet (XUV) spectra of three astrophysically abundant elements (Fe, Ca and Ne) from three different tokamak plasmas. In every case, each spectrum touches on an issue of atomic physics that is important for simulation codes to be used in the analysis of high spectral resolution data from current and future x-ray telescopes. The utility of the tokamak as a laboratory test bed for astrophysical data is demonstrated. Simple models generated with the HULLAC suite of codes demonstrate how the atomic physics issues studied can affect the interpretation of astrophysical data.

  2. Electron cyclotron emission diagnostics on KSTAR tokamak.

    PubMed

    Jeong, S H; Lee, K D; Kogi, Y; Kawahata, K; Nagayama, Y; Mase, A; Kwon, M

    2010-10-01

    A new electron cyclotron emission (ECE) diagnostics system was installed for the Second Korea Superconducting Tokamak Advanced Research (KSTAR) campaign. The new ECE system consists of an ECE collecting optics system, an overmode circular corrugated waveguide system, and 48 channel heterodyne radiometer with the frequency range of 110-162 GHz. During the 2 T operation of the KSTAR tokamak, the electron temperatures as well as its radial profiles at the high field side were measured and sawtooth phenomena were also observed. We also discuss the effect of a window on in situ calibration. PMID:21033954

  3. Rotation of tokamak halo currents

    SciTech Connect

    Boozer, Allen H.

    2012-05-15

    During tokamak disruptions, halo currents, which can be tenths of the total plasma current, can flow at the plasma edge along the magnetic field lines that intercept the chamber walls. Non-axisymmetric halo currents are required to maintain force balance as the plasma kinks when the edge safety factor drops to about two in a vertical displacement event. The plasma quickly assumes a definite toroidal velocity v{sub a}(r) with respect to that of the magnetic kink, v{sub k}, where v{sub a}(r) is set by the radial electric field required for ambipolarity. The plasma velocity, v{sub pl}=v{sub a}+v{sub k}, near the edge is influenced by the interaction with neutrals and with the potential in the halo required for quasi-neutrality on open magnetic field lines, and the plasma velocity in the core is influenced by external error fields. When plasma effects dominate magnetic locking, the magnetic kink should rotate at a diamagnetic speed of either the edge or the core. If the magnetic field lines of the halo plasma intercept the wall at locations of very different electrical conductivity, the toroidal rotation of the halo currents can intermittently stall at wall locations of high conductivity. Such stalling is seen in experiments. The toroidal phase difference between the stalled halo currents and the kink, which is expected to rotate smoothly, must satisfy {delta}{phi}<{+-}{pi}/2. A concern cited by ITER engineers is that the time varying force of the rotating halo could substantially increase the disruption loads on in-vessel components.

  4. Rotation of tokamak halo currents

    NASA Astrophysics Data System (ADS)

    Boozer, Allen H.

    2012-05-01

    During tokamak disruptions, halo currents, which can be tenths of the total plasma current, can flow at the plasma edge along the magnetic field lines that intercept the chamber walls. Non-axisymmetric halo currents are required to maintain force balance as the plasma kinks when the edge safety factor drops to about two in a vertical displacement event. The plasma quickly assumes a definite toroidal velocity va(r) with respect to that of the magnetic kink, vk, where va(r) is set by the radial electric field required for ambipolarity. The plasma velocity, vpl=va+vk, near the edge is influenced by the interaction with neutrals and with the potential in the halo required for quasi-neutrality on open magnetic field lines, and the plasma velocity in the core is influenced by external error fields. When plasma effects dominate magnetic locking, the magnetic kink should rotate at a diamagnetic speed of either the edge or the core. If the magnetic field lines of the halo plasma intercept the wall at locations of very different electrical conductivity, the toroidal rotation of the halo currents can intermittently stall at wall locations of high conductivity. Such stalling is seen in experiments. The toroidal phase difference between the stalled halo currents and the kink, which is expected to rotate smoothly, must satisfy δϕ <±π/2. A concern cited by ITER engineers is that the time varying force of the rotating halo could substantially increase the disruption loads on in-vessel components.

  5. Stabilization of tokamak plasma by lithium streams

    SciTech Connect

    L.E. Zakharov

    2000-08-07

    The stabilization theory of free-boundary magnetohydrodynamic instabilities in tokamaks by liquid lithium streams driven by magnetic propulsion is formulated. While the conventional, wall-locked, resistive wall mode can be well suppressed by the flow, a new, stream-locked mode determines the limits of the flow stabilization.

  6. Transformer Recharging with Alpha Channeling in Tokamaks

    SciTech Connect

    N.J. Fisch

    2009-12-21

    Transformer recharging with lower hybrid waves in tokamaks can give low average auxiliary power if the resistivity is kept high enough during the radio frequency (rf) recharging stage. At the same time, operation in the hot ion mode via alpha channeling increases the effective fusion reactivity. This paper will address the extent to which these two large cost saving steps are compatible. __________________________________________________

  7. Banana drift transport in tokamaks with ripple

    SciTech Connect

    Linsker, R.; Boozer, A.H.

    1982-01-01

    Ripple transport in tokamaks is discussed for the ''banana drift'' collisionality regime, which lies below the ripple plateau regime treated earlier. The physical mechanisms that dominate banana drift transport are found to differ from those considered in previous work on this regime, and consequently the resulting transport coefficients can differ by several orders of magnitude.

  8. Banana drift transport in tokamaks with ripple

    SciTech Connect

    Linsker, R.; Boozer, A.H.

    1981-04-01

    Ripple transport in tokamaks is discussed for the banana drift collisionality regime, which lies below the ripple plateau regime treated earlier. The physical mechanisms that dominate banana drift transport are found to differ from those considered in previous work on this regime, and the resulting transport coefficients can consequently differ by several orders of magnitude.

  9. UCLA Tokamak Program Close Out Report.

    SciTech Connect

    Taylor, Robert John

    2014-02-04

    The results of UCLA experimental fusion program are summarized. Starting with smaller devices like Microtor, Macrotor, CCT and ending the research on the large (5 m) Electric Tokamak. CCT was the most diagnosed device for H-mode like physics and the effects of rotation induced radial fields. ICRF heating was also studied but plasma heating of University Type Tokamaks did not produce useful results due to plasma edge disturbances of the antennae. The Electric Tokamak produced better confinement in the seconds range. However, it presented very good particle confinement due to an "electric particle pinch". This effect prevented us from reaching a quasi steady state. This particle accumulation effect was numerically explained by Shaing's enhanced neoclassical theory. The PI believes that ITER will have a good energy confinement time but deleteriously large particle confinement time and it will disrupt on particle pinching at nominal average densities. The US fusion research program did not study particle transport effects due to its undue focus on the physics of energy confinement time. Energy confinement time is not an issue for energy producing tokamaks. Controlling the ash flow will be very expensive.

  10. Tokamak startup with electron cyclotron heating

    SciTech Connect

    Holly, D J; Prager, S C; Shepard, D A; Sprott, J C

    1980-04-01

    Experiments are described in which the startup voltage in a tokamak is reduced by approx. 60% by the use of a modest amount of electron cyclotron resonance heating power for preionization. A 50% reduction in volt-second requirement and impurity reflux are also observed.

  11. Elementary Processes Underlying Alpha Channeling in Tokamaks

    SciTech Connect

    NM.J. Fisch

    2012-06-15

    Alpha channeling in tokamaks is speculative, but also extraordinarily attractive. Waves that can accomplish this effect have been identified. Key aspects of the theory now enjoy experimental confirmation. This paper will review the elementary processes of wave-particle interactions in plasma that underlie the alpha channeling effect

  12. Compact tokamak reactors. Part 1 (analytic results)

    SciTech Connect

    Wootton, A.J.; Wiley, J.C.; Edmonds, P.H.; Ross, D.W.

    1996-09-13

    We discuss the possible use of tokamaks for thermonuclear power plants, in particular tokamaks with low aspect ratio and copper toroidal field coils. Three approaches are presented. First we review and summarize the existing literature. Second, using simple analytic estimates, the size of the smallest tokamak to produce an ignited plasma is derived. This steady state energy balance analysis is then extended to determine the smallest tokamak power plant, by including the power required to drive the toroidal field, and considering two extremes of plasma current drive efficiency. The analytic results will be augmented by a numerical calculation which permits arbitrary plasma current drive efficiency; the results of which will be presented in Part II. Third, a scaling from any given reference reactor design to a copper toroidal field coil device is discussed. Throughout the paper the importance of various restrictions is emphasized, in particular plasma current drive efficiency, plasma confinement, plasma safety factor, plasma elongation, plasma beta, neutron wall loading, blanket availability and recirculating electric power. We conclude that the latest published reactor studies, which show little advantage in using low aspect ratio unless remarkably high efficiency plasma current drive and low safety factor are combined, can be reproduced with the analytic model.

  13. Toroidal Alfven wave stability in ignited tokamaks

    SciTech Connect

    Cheng, C.Z.; Fu, G.Y.; Van Dam, J.W.

    1989-01-01

    The effects of fusion-product alpha particles on the stability of global-type shear Alfven waves in an ignited tokamak plasma are investigated in toroidal geometry. Finite toroidicity can lead to stabilization of the global Alfven eigenmodes, but it induces a new global shear Alfven eigenmodes, which is strongly destabilized via transit resonance with alpha particles. 8 refs., 2 figs.

  14. Microinstabilities in weak density gradient tokamak systems

    SciTech Connect

    Tang, W.M.; Rewoldt, G.; Chen, L.

    1986-04-01

    A prominent characteristic of auxiliary-heated tokamak discharges which exhibit improved (''H-mode type'') confinement properties is that their density profiles tend to be much flatter over most of the plasma radius. Depsite this favorable trend, it is emphasized here that, even in the limit of zero density gradient, low-frequency microinstabilities can persist due to the nonzero temperature gradient.

  15. Analysis of sawtooth relaxation oscillations in tokamaks

    SciTech Connect

    Yamazaki, K.; McGuire, K.; Okabayashi, M.

    1982-07-01

    Sawtooth relaxation oscillations are analyzed using the Kadomtsev's disruption model and a thermal relaxation model. The sawtooth period is found to be very sensitive to the thermal conduction loss. Qualitative agreement between these calculations and the sawtooth period observed in several tokamaks is demonstrated.

  16. INTEGRATED PLASMA CONTROL FOR ADVANCED TOKAMAKS

    SciTech Connect

    HUMPHREYS,D.A; FERRON,J.R; JOHNSON,R.D; LEUER,J.A; PENAFLOR,B.G; WALKER,M.L; WELANDER,A.S; KHAYRUTDINOV,R.R; DOKOUKA,V; EDGELL,D.H; FRANSSON,C.M

    2003-10-01

    OAK-B135 Advanced tokamaks (AT) are distinguished from conventional tokamaks by their high degree of shaping, achievement of profiles optimized for high confinement and stability characteristics, and active stabilization of MHD instabilities to attain high values of normalized beta and confinement. These high performance fusion devices thus require accurate regulation of the plasma boundary, internal profiles, pumping, fueling, and heating, as well as simultaneous and well-coordinated MHD control action to stabilize such instabilities as tearing modes and resistive wall modes. Satisfying the simultaneous demands on control accuracy, reliability, and performance for all of these subsystems requires a high degree of integration in both design and operation of the plasma control system in an advanced tokamak. The present work describes the approach, benefits, and progress made in integrated plasma control with application examples drawn from the DIII-D tokamak. The approach includes construction of plasma and system response models, validation of models against operating experiments, design of integrated controllers which operate in concert with one another as well as with supervisory modules, simulation of control action against off-line and actual machine control platforms, and iteration of the design-test loop to optimize performance.

  17. Spontaneous generation of rotation in tokamak plasmas

    SciTech Connect

    Parra Diaz, Felix

    2013-12-24

    Three different aspects of intrinsic rotation have been treated. i) A new, first principles model for intrinsic rotation [F.I. Parra, M. Barnes and P.J. Catto, Nucl. Fusion 51, 113001 (2011)] has been implemented in the gyrokinetic code GS2. The results obtained with the code are consistent with several experimental observations, namely the rotation peaking observed after an L-H transition, the rotation reversal observed in Ohmic plasmas, and the change in rotation that follows Lower Hybrid wave injection. ii) The model in [F.I. Parra, M. Barnes and P.J. Catto, Nucl. Fusion 51, 113001 (2011)] has several simplifying assumptions that seem to be satisfied in most tokamaks. To check the importance of these hypotheses, first principles equations that do not rely on these simplifying assumptions have been derived, and a version of these new equations has been implemented in GS2 as well. iii) A tokamak cross-section that drives large intrinsic rotation has been proposed for future large tokamaks. In large tokamaks, intrinsic rotation is expected to be very small unless some up-down asymmetry is introduced. The research conducted under this contract indicates that tilted ellipticity is the most efficient way to drive intrinsic rotation.

  18. Burning plasma simulation and environmental assessment of tokamak, spherical tokamak and helical reactors

    NASA Astrophysics Data System (ADS)

    Yamazaki, K.; Uemura, S.; Oishi, T.; Garcia, J.; Arimoto, H.; Shoji, T.

    2009-05-01

    Reference 1-GWe DT reactors (tokamak TR-1, spherical tokamak ST-1 and helical HR-1 reactors) are designed using physics, engineering and cost (PEC) code, and their plasma behaviours with internal transport barrier operations are analysed using toroidal transport analysis linkage (TOTAL) code, which clarifies the requirement of deep penetration of pellet fuelling to realize steady-state advanced burning operation. In addition, economical and environmental assessments were performed using extended PEC code, which shows the advantage of high beta tokamak reactors in the cost of electricity (COE) and the advantage of compact spherical tokamak in life-cycle CO2 emission reduction. Comparing with other electric power generation systems, the COE of the fusion reactor is higher than that of the fission reactor, but on the same level as the oil thermal power system. CO2 reduction can be achieved in fusion reactors the same as in the fission reactor. The energy payback ratio of the high-beta tokamak reactor TR-1 could be higher than that of other systems including the fission reactor.

  19. Banana orbits in elliptic tokamaks with hole currents

    NASA Astrophysics Data System (ADS)

    Martin, P.; Castro, E.; Puerta, J.

    2015-03-01

    Ware Pinch is a consequence of breaking of up-down symmetry due to the inductive electric field. This symmetry breaking happens, though up-down symmetry for magnetic surface is assumed. In previous work Ware Pinch and banana orbits were studied for tokamak magnetic surface with ellipticity and triangularity, but up-down symmetry. Hole currents appear in large tokamaks and their influence in Ware Pinch and banana orbits are now considered here for tokamaks magnetic surfaces with ellipticity and triangularity.

  20. The physics of tokamak start-upa)

    NASA Astrophysics Data System (ADS)

    Mueller, D.

    2013-05-01

    Tokamak start-up on present-day devices usually relies on inductively induced voltage from a central solenoid. In some cases, inductive startup is assisted with auxiliary power from electron cyclotron radio frequency heating. International Thermonuclear Experimental Reactor, the National Spherical Torus Experiment Upgrade and JT60, now under construction, will make use of the understanding gained from present-day devices to ensure successful start-up. Design of a spherical tokamak (ST) with DT capability for nuclear component testing would require an alternative to a central solenoid because the small central column in an ST has insufficient space to provide shielding for the insulators in the solenoid. Alternative start-up techniques such as induction using outer poloidal field coils, electron Bernstein wave start-up, coaxial helicity injection, and point source helicity injection have been used with success, but require demonstration of scaling to higher plasma current.

  1. Decommissioning the Tokamak Fusion Test Reactor

    SciTech Connect

    Spampinato, P.T.; Walton, G.R.

    1993-10-01

    The Tokamak Fusion Test Reactor (TFTR) at Princeton Plasma Physics Laboratory (PPPL) will complete its experimental lifetime with a series of deuterium-tritium pulses in 1994. As a result, the machine structures will become radioactive, and vacuum components will also be contaminated with tritium. Dose rate levels will range from less than 1 mr/h for external structures to hundreds of mr/h for the vacuum vessel. Hence, decommissioning operations will range from hands on activities to the use of remotely operated equipment. After 21 months of cool down, decontamination and decommissioning (D and D) operations will commence and continue for approximately 15 months. The primary objective is to render the test cell complex re-usable for the next machine, the Tokamak Physics Experiment (TPX). This paper presents an overview of decommissioning TFTR and discusses the D and D objectives.

  2. Rapidly Moving Divertor Plates In A Tokamak

    SciTech Connect

    S. Zweben

    2011-05-16

    It may be possible to replace conventional actively cooled tokamak divertor plates with a set of rapidly moving, passively cooled divertor plates on rails. These plates would absorb the plasma heat flux with their thermal inertia for ~10-30 sec, and would then be removed from the vessel for processing. When outside the tokamak, these plates could be cooled, cleaned, recoated, inspected, and then returned to the vessel in an automated loop. This scheme could provide nearoptimal divertor surfaces at all times, and avoid the need to stop machine operation for repair of damaged or eroded plates. We describe various possible divertor plate designs and access geometries, and discuss an initial design for a movable and removable divertor module for NSTX-U.

  3. Nonambipolar transport by trapped particles in tokamaks.

    PubMed

    Park, Jong-Kyu; Boozer, Allen H; Menard, Jonathan E

    2009-02-13

    Small nonaxisymmetric perturbations of the magnetic field can greatly change the performance of tokamaks through nonambipolar transport. A number of theories have been developed, but the predictions were not consistent with experimental observations in tokamaks. This Letter provides a resolution, with a generalized analytic treatment of the nonambipolar transport. It is shown that the discrepancy between theory and experiment can be greatly reduced by two effects: (1) the small fraction of trapped particles for which the bounce and precession rates resonate; (2) the nonaxisymmetric variation in the field strength along the perturbed magnetic field lines rather than along the unperturbed magnetic field lines. The expected sensitivity of the International Thermonuclear Experimental Reactor to nonaxisymmetries is also discussed. PMID:19257595

  4. Microtearing modes in spherical and conventional tokamaks

    NASA Astrophysics Data System (ADS)

    Moradi, S.; Pusztai, I.; Guttenfelder, W.; Fülöp, T.; Mollén, A.

    2013-06-01

    The onset and characteristics of microtearing modes (MTM) in the core of spherical (NSTX) and conventional tokamaks (ASDEX Upgrade and JET) are studied through local linear gyrokinetic simulations with GYRO (Candy and Belli 2011 General Atomics Report GA-A26818). For experimentally relevant core plasma parameters in the NSTX and ASDEX Upgrade tokamaks, in agreement with previous works, we find MTMs as the dominant linear instability. Also, for JET-like core parameters considered in our study an MTM is found as the most unstable mode. In all of these plasmas, finite collisionality is needed for MTMs to become unstable and the electron temperature gradient is found to be the fundamental drive. However, a significant difference is observed in the dependence of the linear growth rate of MTMs on electron temperature gradient. While it varies weakly and non-monotonically in JET and ASDEX Upgrade plasmas, in NSTX it increases with the electron temperature gradient.

  5. Tritium Retention and Removal in Tokamaks

    SciTech Connect

    Skinner, Charles H.

    2009-02-19

    Management of tritium inventory remains one of the grand challenges in the development of fusion energy. Tritium is an important source term in safety assessments, it is expensive and in short supply. Tritium can be continuously retained in a tokamak by codeposition with eroded carbon or beryllium and JET and TFTR with carbon plasma facing components showed a tritium retention level that would be unacceptable in ITER or future fusion reactors. Asdex-U and Alcator C-mod have shown reduced hydrogenic retention with tungsten clad and molybdenum plasma facing components. Once the tritium inventory approaches the administrative limit, tritium must be removed to permit continued D-T plasma operations. Several candidate techniques are being considered and need to be proven at a relevant speed and efficiency in contemporary tokamaks. Projections for ITER are discussed.

  6. The Physics of Tokamak Start-up

    SciTech Connect

    D. Mueller

    2012-11-13

    Tokamak start-up on present-day devices usually relies on inductively induced voltage from a central solenoid. In some cases inductive startup is assisted with auxiliary power from electron cyclotron radio frequency heating. ITER, the National Spherical Torus eXperiment Upgrade and JT60, now under construction, will make use of the understanding gained from present-day devices to ensure successful start-up. Design of a spherical tokamak (ST) with DT capability for nuclear component testing would require an alternative to a central solenoid because the small central column in an ST has insufficient space to provide shielding for the insulators in the solenoid. Alternative start-up techniques such as induction using outer poloidal field coils, electron Bernstein wave start-up, coaxial helicity injection and point source helicity injection have been used with success, but require demonstration of scaling to higher plasma current.

  7. The physics of tokamak start-up

    SciTech Connect

    Mueller, D.

    2013-05-15

    Tokamak start-up on present-day devices usually relies on inductively induced voltage from a central solenoid. In some cases, inductive startup is assisted with auxiliary power from electron cyclotron radio frequency heating. International Thermonuclear Experimental Reactor, the National Spherical Torus Experiment Upgrade and JT60, now under construction, will make use of the understanding gained from present-day devices to ensure successful start-up. Design of a spherical tokamak (ST) with DT capability for nuclear component testing would require an alternative to a central solenoid because the small central column in an ST has insufficient space to provide shielding for the insulators in the solenoid. Alternative start-up techniques such as induction using outer poloidal field coils, electron Bernstein wave start-up, coaxial helicity injection, and point source helicity injection have been used with success, but require demonstration of scaling to higher plasma current.

  8. A low aspect ratio tokamak transmutation system

    NASA Astrophysics Data System (ADS)

    Qiu, L. J.; Wu, Y. C.; Xiao, B. J.; Xu, Q.; Huang, Q. Y.; Wu, B.; Chen, Y. X.; Xu, W. N.; Chen, Y. P.; Liu, X. P.

    2000-03-01

    A low aspect ratio tokamak transmutation system is proposed as an alternative application of fusion energy on the basis of a review of previous studies. This system includes: (1) a low aspect ratio tokamak as fusion neutron driver, (2) a radioactivity-clean nuclear power system as blanket, and (3) a novel concept of liquid metal centre conductor post as part of the toroidal field coils. In the conceptual design, a driver of 100 MW fusion power under 1 MW/m2 neutron wall loading can transmute the amount of high level waste (including minor actinides and fission products) produced by ten standard pressurized water reactors of 1 GW electrical power output. Meanwhile, the system can produce tritium on a self-sustaining basis and an output of about 2 GW of electrical energy. After 30 years of operation, the biological hazard potential level of the whole system will decrease by two orders of magnitude.

  9. Boundary Plasma Turbulence Simulations for Tokamaks

    SciTech Connect

    Xu, X; Umansky, M; Dudson, B; Snyder, P

    2008-05-15

    The boundary plasma turbulence code BOUT models tokamak boundary-plasma turbulence in a realistic divertor geometry using modified Braginskii equations for plasma vorticity, density (ni), electron and ion temperature (T{sub e}; T{sub i}) and parallel momenta. The BOUT code solves for the plasma fluid equations in a three dimensional (3D) toroidal segment (or a toroidal wedge), including the region somewhat inside the separatrix and extending into the scrape-off layer; the private flux region is also included. In this paper, a description is given of the sophisticated physical models, innovative numerical algorithms, and modern software design used to simulate edge-plasmas in magnetic fusion energy devices. The BOUT code's unique capabilities and functionality are exemplified via simulations of the impact of plasma density on tokamak edge turbulence and blob dynamics.

  10. System studies of Compact Ignition Tokamaks

    SciTech Connect

    Galambos, J.D.; Peng, Y.K.M.; Blackfield, D.T.

    1986-11-01

    The Fusion Engineering Design Center (FEDC) Tokamak Systems Code is used to perform trade studies in accordance with the Compact Ignition Tokamak (CIT) physics and engineering guidelines. The authors examine various toroidal field coil (TFC) configurations, preload levels, and coil materials. Use of Inconel-copper composite material results in the smallest sized devices for both bucked and wedged TFCs and wedged-only TFCs. Preload levels of 23 Mkg are needed for the minimum sized devices, and for the lower strength materials, the minimum size is sensitive to the preload level. Results from these trade studies help lead to the choice of the baseline CIT point at R = 1.25 m and B = 10.4 T.

  11. First Engineering Commissioning of EAST Tokamak

    NASA Astrophysics Data System (ADS)

    Wan, Yuanxi; Li, Jiangang; Weng, Peide; EAST Team

    2006-05-01

    Experimental Advanced Superconducting Tokamak (EAST) is the first fully superconducting tokamak. The first commissioning started on Feb. 1st of 2006 and finished on March 30th of 2006 at the Institute of Plasma Physics, Chinese Academy of Sciences. It consists of leakage testing at both room temperature and low temperature, pumping down, cooling down all coils, current leads, bus bar and the thermal shielding, exciting all the coils, measuring magnetic configuration and warming up the magnets. The electromagnetic, thermal hydraulic and mechanical performance of EAST Toroidal Field (TF) and Poloidal Field (PF) magnets have also been tested. All sub-systems, including pumping system, cryogenic system, PF& TF power supply systems, magnet instrumentation system, quench detection and protection system, water cooling system, data acquisition system, main control system, plasma control system (PCS), interlock and safety system have been successfully tested.

  12. First Results of the ETE Spherical Tokamak

    NASA Astrophysics Data System (ADS)

    Ludwig, G. O.; del Bosco, E.; Ferreira, J. G.; Barroso, J. J.; Berni, L. A.; Oliveira, R. M.

    2001-10-01

    First tokamak plasma discharges were obtained in the ETE Spherical Tokamak Experiment (Experimento Tokamak Esferico) by November 2000. ETE is a medium size machine (major radius R=0.30m) with a compact design and good access for diagnostics. During the first phase of operation a plasma current of 200kA (t=15ms) will be produced in a 1.5 aspect ratio configuration with a toroidal magnetic field up to 0.4T. The ultimate values are limited by mechanical stresses in the joints of the toroidal field coil (B<0.8T), and by stresses and heating in the solenoid (0.24Wb, 30kA, 0.2s) for a maximum plasma current of about 400kA. Presently the experiments are focused on plasma formation, vacuum conditioning and diagnostics implementation. The machine was constructed in accordance with stringent design specifications. The assembly has an overall precision better than 2mm. Vacuum conditioning is being improved with baking, glow discharge cleaning and usual tokamak operation. Breakdown is easily obtained even without the pre-ionization provided by a hot filament electron emitter and by an ultraviolet lamp. Preliminary measurements of stray magnetic fields were carried out and eddy current effects are being modeled. Energy of the capacitor banks is being continuously increased to achieve the design parameters. A fast neutral lithium beam probe for plasma edge studies and a 6.7GHz high-power monotron for pre-ionization and electron cyclotron resonance plasma heating experiments are under development.

  13. Tokamak with liquid metal toroidal field coil

    DOEpatents

    Ohkawa, Tihiro; Schaffer, Michael J.

    1981-01-01

    Tokamak apparatus includes a pressure vessel for defining a reservoir and confining liquid therein. A toroidal liner disposed within the pressure vessel defines a toroidal space within the liner. Liquid metal fills the reservoir outside said liner. Electric current is passed through the liquid metal over a conductive path linking the toroidal space to produce a toroidal magnetic field within the toroidal space about the major axis thereof. Toroidal plasma is developed within the toroidal space about the major axis thereof.

  14. Neoclassical transport in high [beta] tokamaks

    SciTech Connect

    Cowley, S.C.

    1992-12-01

    Neoclassical, transport in high [beta] large aspect ratio tokamaks is calculated. The variational method introduced by Rosenbluth, et al., is used to calculate the full Onsager matrix in the banana regime. These results are part of a continuing study of the high [beta] large aspect ratio equilibria introduced in Cowley, et al. All the neoclassical coefficients are reduced from their nominal low [beta] values by a factor ([var epsilon]/q[sup 2][beta])[sup [1/2

  15. High beta plasmas in the PBX tokamak

    SciTech Connect

    Bol, K.; Buchenauer, D.; Chance, M.; Couture, P.; Fishman, H.; Fonck, R.; Gammel, G.; Grek, B.; Ida, K.; Itami, K.

    1986-04-01

    Bean-shaped configurations favorable for high ..beta.. discharges have been investigated in the Princeton Beta Experiment (PBX) tokamak. Strongly indented bean-shaped plasmas have been successfully formed, and beta values of over 5% have been obtained with 5 MW of injected neutral beam power. These high beta discharges still lie in the first stability regime for ballooning modes, and MHD stability analysis implicates the external kink as responsible for the present ..beta.. limit.

  16. Neoclassical tearing modes in a tokamak

    SciTech Connect

    Hahm, T.S.

    1988-08-01

    Linear tearing instability is studied in the banana collisionality regime in tokamak geometry. Neoclassical effects produce significant modifications of Ohm's law and the vorticity equation so that the growth rate of tearing modes driven by ..delta..' is dramatically reduced compared to the usual resistive MHD value. Consequences of this result, regarding the presence of pressure-gradient-driven neoclassical resistive interchange instabilities and the evolution of magnetic islands in the Rutherford regime, are discussed. 10 refs.

  17. Neoclassical tearing modes in a tokamak

    SciTech Connect

    Hahm, T.S.

    1988-12-01

    Linear tearing instability is studied in the banana collisionality regime in tokamak geometry. Neoclassical effects produce significant modifications of Ohm's law and the vorticity equation, so that the growth rate of tearing modes driven by ..delta..' is dramatically reduced compared to the usual resistive magnetohydrodynamic values. Consequences of this result, regarding the presence of pressure-gradient-driven neoclassical resistive interchange instabilities and the evolution of magnetic islands in the Rutherford regime, are discussed.

  18. Self-Organized Stationary States of Tokamaks

    SciTech Connect

    Jardin, S. C.; Ferraro, N.; Krebs, I.

    2015-11-01

    We demonstrate that in a 3D resistive magnetohydrodynamic simulation, for some parameters it is possible to form a stationary state in a tokamak where a saturated interchange mode in the center of the discharge drives a near helical flow pattern that acts to nonlinearly sustain the configuration by adjusting the central loop voltage through a dynamo action. This could explain the physical mechanism for maintaining stationary nonsawtoothing "hybrid" discharges, often referred to as "flux pumping."

  19. Confinement scaling and ignition in tokamaks

    SciTech Connect

    Perkins, F.W.; Sun, Y.C.

    1985-10-01

    A drift wave turbulence model is used to compute the scaling and magnitude of central electron temperature and confinement time of tokamak plasmas. The results are in accord with experiment. Application to ignition experiments shows that high density (1 to 2) . 10/sup 15/ cm/sup -3/, high field, B/sub T/ > 10 T, but low temperature T approx. 6 keV constitute the optimum path to ignition.

  20. Plasma filamentation in the Rijnhuizen tokamak RTP

    SciTech Connect

    Lopes Cardozo, N.J.; Schueller, F.C.; Barth, C.J.; Chu, C.C.; Pijper, F.J.; Lok, J.; Oomens, A.A.M. )

    1994-07-11

    Evidence for small scale magnetic structures in the Rijnhuizen tokamak RTP is presented. These are manifest through steps and peaks in the electron temperature and pressure, measured with multiposition Thomson scattering. During central electron cyclotron heating, several filaments of high pressure are found in the power deposition region. They live hundreds of microseconds. Near the sawtooth inversion radius a step'' in the temperature profile occurs. Further out, quasiperiodic structures are observed, in both Ohmic and heated discharges.

  1. Self-Organized Stationary States of Tokamaks.

    PubMed

    Jardin, S C; Ferraro, N; Krebs, I

    2015-11-20

    We demonstrate that in a 3D resistive magnetohydrodynamic simulation, for some parameters it is possible to form a stationary state in a tokamak where a saturated interchange mode in the center of the discharge drives a near helical flow pattern that acts to nonlinearly sustain the configuration by adjusting the central loop voltage through a dynamo action. This could explain the physical mechanism for maintaining stationary nonsawtoothing "hybrid" discharges, often referred to as "flux pumping." PMID:26636854

  2. Comparison of tokamak burn cycle options

    SciTech Connect

    Ehst, D.A.; Brooks, J.N.; Cha, Y.; Evans, K. Jr.; Hassanein, A.M.; Kim, S.; Majumdar, S.; Misra, B.; Stevens, H.C.

    1985-01-01

    Experimental confirmation of noninductive current drive has spawned a number of suggestions as to how this technique can be used to extend the fusion burn period and improve the reactor prospects of tokamaks. Several distinct burn cycles, which employ various combinations of Ohmic and noninductive current generation, are possible, and we will study their relative costs and benefits for both a commerical reactor as well as an INTOR-class device. We begin with a review of the burn cycle options.

  3. Multiple mode model of tokamak transport

    SciTech Connect

    Singer, C.E.; Ghanem, E.S.; Bateman, G.; Stotler, D.P.

    1989-07-01

    Theoretical models for radical transport of energy and particles in tokamaks due to drift waves, rippling modes, and resistive ballooning modes have been combined in a predictive transport code. The resulting unified model has been used to simulate low confinement mode (L-mode) energy confinement scalings. Dependence of global energy confinement on electron density for the resulting model is also described. 26 refs., 1 fig., 2 tabs.

  4. Development of a free-boundary tokamak equilibrium solver for advanced study of tokamak equilibria

    NASA Astrophysics Data System (ADS)

    Jeon, Young Mu

    2015-09-01

    A free-boundary Tokamak equilibrium solver (TES), developed for advanced study of tokamak equilibra, is described with two distinctive features. One is a generalized method to resolve the intrinsic axisymmetric instability, which is encountered in all equilibrium calculations with a freeboundary condition. The other is an extension to deal with a new divertor geometry such as snowflake or X divertors. For validations, the uniqueness of a solution is confirmed by the independence of variations in the computational domain, the mathematical correctness and accuracy of equilibrium profiles are checked by using a direct comparison with an analytic equilibrium known as a generalized Solov'ev equilibrium, and the governing force balance relation is tested by examining the intrinsic axisymmetric instabilities. As an application of an advanced equilibrium study, a snow-flake divertor configuration that requires a second-order zero of the poloidal magnetic flux is discussed in the circumstance of the Korea superconducting tokamak advanced research (KSTAR) coil system.

  5. Tokamaks: from A D Sakharov to the present (the 60-year history of tokamaks)

    NASA Astrophysics Data System (ADS)

    Azizov, E. A.

    2012-02-01

    The paper is prepared on the basis of the report presented at the session of the Physical Sciences Division of the Russian Academy of Sciences (RAS) at the Lebedev Physical Institute, RAS on 25 May 2011, devoted to the 90-year jubilee of Academician Andrei D Sakharov - the initiator of controlled nuclear fusion research in the USSR. The 60-year history of plasma research work in toroidal devices with a longitudinal magnetic field suggested by Andrei D Sakharov and Igor E Tamm in 1950 for the confinement of fusion plasma and known at present as tokamaks is described in brief. The recent (2006) agreement among Russia, the EU, the USA, Japan, China, the Republic of Korea, and India on the joint construction of the international thermonuclear experimental reactor (ITER) in France based on the tokamak concept is discussed. Prospects for using the tokamak as a thermonuclear (14 MeV) neutron source are examined.

  6. SOL Width Scaling in the MAST Tokamak

    NASA Astrophysics Data System (ADS)

    Ahn, Joon-Wook; Counsell, Glenn; Connor, Jack; Kirk, Andrew

    2002-11-01

    Target heat loads are determined in large part by the upstream SOL heat flux width, Δ_h. Considerable effort has been made in the past to develop analytical and empirical scalings for Δh to allow reliable estimates to be made for the next-step device. The development of scalings for a large spherical tokamak (ST) such as MAST is particularly important both for development of the ST concept and for improving the robustness of scalings derived for conventional tokamaks. A first such scaling has been developed in MAST DND plasmas. The scaling was developed by flux-mapping data from the target Langmuir probe arrays to the mid-plane and fitting to key upstream parameters such as P_SOL, bar ne and q_95. In order to minimise the effects of co-linearity, dedicated campaigns were undertaken to explore the widest possible range of each parameter while keeping the remainder as fixed as possible. Initial results indicate a weak inverse dependence on P_SOL and approximately linear dependence on bar n_e. Scalings derived from consideration of theoretical edge transport models and integration with data from conventional devices is under way. The established scaling laws could be used for the extrapolations to the future machine such as Spherical Tokamak Power Plant (STPP). This work is jointly funded by Euratom and UK Department of Trade and Industry. J-W. Ahn would like to recognise the support of a grant from the British Foreign & Commonwealth Office.

  7. Management and protection system for superconducting tokamak

    NASA Astrophysics Data System (ADS)

    Juszczyk, B.; Wojenski, A.; Zienkiewicz, P.; Kasprowicz, G.; Pozniak, K.; Romaniuk, R.

    2015-09-01

    This paper describes system for a diagnostics of a high-voltage power supply section of tokamaks. System is designed to assure reliability and safety of power supply subsystems. It is divided into two main components: remote and local. Remote part is located near tokamak, whereas local part can be localised away from the tokamak area. The remote side consists of custom, standalone devices. On the other hand, the local device is based on the uTCA.4 architecture. Components are connected with an optic fibre over a link-layer protocol which provides high throughput, low latency and transmission redundancy. All main operations ie. data processing, transmission etc. are performed on the FPGA devices. At the local side there is one device treated as a master device. It implements sort of a routing table which connects consecutive system inputs and outputs. It also provides possibility for some user defined data processing. This document contains general system overview, short description of hardware used in the project and gateware implementation.

  8. Spherical tokamaks with plasma centre-post

    NASA Astrophysics Data System (ADS)

    Ribeiro, Celso

    2013-10-01

    The metal centre-post (MCP) in tokamaks is a structure which carries the total toroidal field current and also houses the Ohmic heating solenoid in conventional or low aspect ratio (Spherical)(ST) tokamaks. The MCP and solenoid are critical components for producing the toroidal field and for the limited Ohmic flux in STs. Constraints for a ST reactor related to these limitations lead to a minimum plasma aspect ratio of 1.4 which reduces the benefit of operation at higher betas in a more compact ST reactor. Replacing the MCP is of great interest for reactor-based ST studies since the device is simplified, compactness increased, and maintenance reduced. An experiment to show the feasibility of using a plasma centre-post (PCP) is being currently under construction and involves a high level of complexity. A preliminary study of a very simple PCP, which is ECR(Electron Cyclotron Resonance)-assisted and which includes an innovative fuelling system based on pellet injection, has recently been reported. This is highly suitable for an ultra-low aspect ratio tokamak (ULART) device. Advances on this PCP ECR-assisted concept within a ULART and the associated fuelling system are presented here, and will include the field topology for the PCP ECR-assisted scheme, pellet ablation modeling, and a possible global equilibrium simulation. VIE-ITCR, IAEA-CRP contr.17592, National Instruments-Costa Rica.

  9. Remote feedback stabilization of tokamak instabilities

    SciTech Connect

    Sen, A.K. )

    1994-05-01

    A novel remote suppressor consisting of an injected ion beam has been used for the stabilization of plasma instabilities. A collisionless curvature-driven trapped-particle instability, an [bold E][times][bold B] flute mode and an ion temperature gradient (ITG) instability have been successfully suppressed down to noise levels using this scheme. Furthermore, the first experimental demonstration of a multimode feedback stabilization with a single sensor--suppressor pair has been achieved. Two modes (an [bold E][times][bold B] flute and an ITG mode) were simultaneously stabilized with a simple state-feedback-type method where more state'' information was generated from a single-sensor Langmuir probe by appropriate signal processing. The above experiments may be considered as paradigms for controlling several important tokamak instabilities. First, feedback suppression of edge fluctuations in a tokamak with a suitable form of insulated segmented poloidal limiter sections used as Langmuir-probe-like suppressors is proposed. Other feedback control schemes are proposed for the suppression of electrostatic core fluctuations via appropriately phased ion density input from a modulated neutral beam. Most importantly, a scheme to control major disruptions in tokamaks via feedback suppression of kink (and possibly) tearing modes is discussed. This may be accomplished by using a modulated neutral beam suppressor in a feedback loop, which will supply a momentum input of appropriate phase and amplitude. Simple theoretical models predict modest levels of beam energy, current, and power.

  10. Edge-localized-modes in tokamaks

    SciTech Connect

    Leonard, A. W.

    2014-09-15

    Edge-localized-modes (ELMs) are a ubiquitous feature of H-mode in tokamaks. When gradients in the H-mode transport barrier grow to exceed the MHD stability limit the ELM instability grows explosively, rapidly transporting energy and particles onto open field lines and material surfaces. Though ELMs provide additional particle and impurity transport through the H-mode transport barrier, enabling steady operation, the resulting heat flux transients to plasma facing surfaces project to large amplitude in future low collisionality burning plasma tokamaks. Measurements of the ELM heat flux deposition onto material surfaces in the divertor and main chamber indicate significant broadening compared to inter-ELM heat flux, with a timescale for energy deposition that is consistent with sonic ion flow and numerical simulation. Comprehensive ELM simulation is highlighting the important physics processes of ELM transport including parallel transport due to magnetic reconnection and turbulence resulting from collapse of the H-mode transport barrier. Encouraging prospects for ELM control and/or suppression in future tokamaks include intrinsic modes of ELM free operation, ELM triggering with frequent small pellet injection and the application of 3D magnetic fields.

  11. Forced Magnetic Reconnection In A Tokamak Plasma

    NASA Astrophysics Data System (ADS)

    Callen, J. D.; Hegna, C. C.

    2015-11-01

    The theory of forced magnetic field reconnection induced by an externally imposed resonant magnetic perturbation usually uses a sheared slab or cylindrical magnetic field model and often focuses on the potential time-asymptotic induced magnetic island state. However, tokamak plasmas have significant magnetic geometry and dynamical plasma toroidal rotation screening effects. Also, finite ion Larmor radius (FLR) and banana width (FBW) effects can damp and thus limit the width of a nascent magnetic island. A theory that is more applicable for tokamak plasmas is being developed. This new model of the dynamics of forced magnetic reconnection considers a single helicity magnetic perturbation in the tokamak magnetic field geometry, uses a kinetically-derived collisional parallel electron flow response, and employs a comprehensive dynamical equation for the plasma toroidal rotation frequency. It is being used to explore the dynamics of bifurcation into a magnetically reconnected state in the thin singular layer around the rational surface, evolution into a generalized Rutherford regime where the island width exceeds the singular layer width, and assess the island width limiting effects of FLR and FBW polarization currents. Support by DoE grants DE-FG02-86ER53218, DE-FG02-92ER54139.

  12. The Spherical Tokamak MEDUSA for Mexico

    NASA Astrophysics Data System (ADS)

    Ribeiro, C.; Salvador, M.; Gonzalez, J.; Munoz, O.; Tapia, A.; Arredondo, V.; Chavez, R.; Nieto, A.; Gonzalez, J.; Garza, A.; Estrada, I.; Jasso, E.; Acosta, C.; Briones, C.; Cavazos, G.; Martinez, J.; Morones, J.; Almaguer, J.; Fonck, R.

    2011-10-01

    The former spherical tokamak MEDUSA (Madison EDUcation Small Aspect.ratio tokamak, R < 0.14m, a < 0.10m, BT < 0.5T, Ip < 40kA, 3ms pulse) is currently being recomissioned at the Universidad Autónoma de Nuevo León, Mexico, as part of an agreement between the Faculties of Mech.-Elect. Eng. and Phy. Sci.-Maths. The main objective for having MEDUSA is to train students in plasma physics & technical related issues, aiming a full design of a medium size device (e.g. Tokamak-T). Details of technical modifications and a preliminary scientific programme will be presented. MEDUSA-MX will also benefit any developments in the existing Mexican Fusion Network. Strong liaison within national and international plasma physics communities is expected. New activities on plasma & engineering modeling are expected to be developed in parallel by using the existing facilities such as a multi-platform computer (Silicon Graphics Altix XE250, 128G RAM, 3.7TB HD, 2.7GHz, quad-core processor), ancillary graph system (NVIDIA Quadro FE 2000/1GB GDDR-5 PCI X16 128, 3.2GHz), and COMSOL Multiphysics-Solid Works programs.

  13. Nonlinear Simulation Studies of Tokamaks and STs

    SciTech Connect

    W. Park; J. Breslau; J. Chen; G.Y. Fu; S.C. Jardin; S. Klasky; J. Menard; A. Pletzer; B.C. Stratton; D. Stutman; H.R. Strauss; L.E. Sugiyama

    2003-07-07

    The multilevel physics, massively parallel plasma simulation code, M3D, has been used to study spherical tori (STs) and tokamaks. The magnitude of outboard shift of density profiles relative to electron temperature profiles seen in NSTX [National Spherical Torus Experiment] under strong toroidal flow is explained. Internal reconnection events in ST discharges can be classified depending on the crash mechanism, just as in tokamak discharges; a sawtooth crash, disruption due to stochasticity, or high-beta disruption. Toroidal shear flow can reduce linear growth of internal kink. It has a strong stabilizing effect nonlinearly and causes mode saturation if its profile is maintained, e.g., through a fast momentum source. Normally, however, the flow profile itself flattens during the reconnection process, allowing a complete reconnection to occur. In some cases, the maximum density and pressure spontaneously occur inside the island and cause mode saturation. Gyrokinetic hot particle/MHD hybrid studies of NSTX show the effects of fluid compression on a fast-ion-driven n = 1 mode. MHD studies of recent tokamak experiments with a central current hole indicate that the current clamping is due to sawtooth-like crashes, but with n = 0.

  14. ADX - Advanced Divertor and RF Tokamak Experiment

    NASA Astrophysics Data System (ADS)

    Greenwald, Martin; Labombard, Brian; Bonoli, Paul; Irby, Jim; Terry, Jim; Wallace, Greg; Vieira, Rui; Whyte, Dennis; Wolfe, Steve; Wukitch, Steve; Marmar, Earl

    2015-11-01

    The Advanced Divertor and RF Tokamak Experiment (ADX) is a design concept for a compact high-field tokamak that would address boundary plasma and plasma-material interaction physics challenges whose solution is critical for the viability of magnetic fusion energy. This device would have two crucial missions. First, it would serve as a Divertor Test Tokamak, developing divertor geometries, materials and operational scenarios that could meet the stringent requirements imposed in a fusion power plant. By operating at high field, ADX would address this problem at a level of power loading and other plasma conditions that are essentially identical to those expected in a future reactor. Secondly, ADX would investigate the physics and engineering of high-field-side launch of RF waves for current drive and heating. Efficient current drive is an essential element for achieving steady-state in a practical, power producing fusion device and high-field launch offers the prospect of higher efficiency, better control of the current profile and survivability of the launching structures. ADX would carry out this research in integrated scenarios that simultaneously demonstrate the required boundary regimes consistent with efficient current drive and core performance.

  15. Numerical investigations of plasma parameters in the COMPASS tokamak

    SciTech Connect

    Havlickova, E.; Zagorski, R.; Panek, R.

    2008-09-15

    A numerical investigation of plasma parameters in a diverter configuration of COMPASS tokamak is presented. The plasma parameters in the device are analyzed in the frame of the self-consistent description of the central plasma and edge region. The possibility of achieving high recycling and detached regimes in the boundary layer of the COMPASS tokamak is discussed.

  16. Recent progress on the Compact Ignition Tokamak (CIT)

    SciTech Connect

    Ignat, D.W.

    1987-01-01

    This report describes work done on the Compact Ignition Tokamak (CIT), both at the Princeton Plasma Physics Laboratory (PPPL) and at other fusion laboratories in the United States. The goal of CIT is to reach ignition in a tokamak fusion device in the mid-1990's. Scientific and engineering features of the design are described, as well as projected cost and schedule.

  17. Physics design requirements for the Tokamak Physics Experiment (TPX)

    SciTech Connect

    Neilson, G.H.; Goldston, R.J.; Jardin, S.C.; Reiersen, W.T.; Nevins, W.M.; Porkolab, M.; Ulrickson, M.

    1993-11-01

    The design of TPX is driven by physics requirements that follow from its mission. The tokamak and heating systems provide the performance and profile controls needed to study advanced steady state tokamak operating modes. The magnetic control systems provide substantial flexibility for the study of regimes with high beta and bootstrap current. The divertor is designed for high steady state power and particle exhaust.

  18. Fokker-Planck/Transport model for neutral beam driven tokamaks

    SciTech Connect

    Killeen, J.; Mirin, A.A.; McCoy, M.G.

    1980-01-01

    The application of nonlinear Fokker-Planck models to the study of beam-driven plasmas is briefly reviewed. This evolution of models has led to a Fokker-Planck/Transport (FPT) model for neutral-beam-driven Tokamaks, which is described in detail. The FPT code has been applied to the PLT, PDX, and TFTR Tokamaks, and some representative results are presented.

  19. Tokamak Physics Experiment (TPX) power supply design and development

    SciTech Connect

    Neumeyer, C.; Bronner, G.; Lu, E.; Ramakrishnan, S.

    1995-04-01

    The Tokamak Physics Experiment (TPX) is an advanced tokamak project aimed at the production of quasi-steady state plasmas with advanced shape, heating, and particle control. TPX is to be built at the Princeton Plasma Physics Laboratory (PPPL) using many of the facilities from the Tokamak Fusion Test Reactor (TFTR). TPX will be the first tokamak to utilize superconducting (SC) magnets in both the toroidal field (TF) and poloidal field (PF) systems. This new feature requires a departure from the traditional tokamak power supply schemes. This paper describes the plan for the adaptation of the PPPL/FTR power system facilities to supply TPX. Five major areas are addressed, namely the AC power system, the TF, PF and Fast Plasma Position Control (FPPC) power supplies, and quench protection for the TF and PF systems. Special emphasis is placed on the development of new power supply and protection schemes.

  20. Mathematical modeling plasma transport in tokamaks

    SciTech Connect

    Quiang, Ji

    1995-12-31

    In this work, the author applied a systematic calibration, validation and application procedure based on the methodology of mathematical modeling to international thermonuclear experimental reactor (ITER) ignition studies. The multi-mode plasma transport model used here includes a linear combination of drift wave branch and ballooning branch instabilities with two a priori uncertain constants to account for anomalous plasma transport in tokamaks. A Bayesian parameter estimation method is used including experimental calibration error/model offsets and error bar rescaling factors to determine the two uncertain constants in the transport model with quantitative confidence level estimates for the calibrated parameters, which gives two saturation levels of instabilities. This method is first tested using a gyroBohm multi-mode transport model with a pair of DIII-D discharge experimental data, and then applied to calibrating a nominal multi-mode transport model against a broad database using twelve discharges from seven different tokamaks. The calibrated transport model is then validated on five discharges from JT-60 with no adjustable constants. The results are in a good agreement with experimental data. Finally, the resulting class of multi-mode tokamak plasma transport models is applied to the transport analysis of the ignition probability in a next generation machine, ITER. A reference simulation of basic ITER engineering design activity (EDA) parameters shows that a self-sustained thermonuclear burn with 1.5 GW output power can be achieved provided that impurity control makes radiative losses sufficiently small at an average plasma density of 1.2 X 10{sup 20}/m{sup 3} with 50 MW auxiliary heating. The ignition probability of ITER for the EDA parameters, can be formally as high as 99.9% in the present context. The same probability for concept design activity (CDA) parameters of ITER, which has smaller size and lower current, is only 62.6%.

  1. Neoclassical Transport Properties of Tokamak Plasmas

    SciTech Connect

    Weyssow, B.

    2004-03-15

    The classical transport theory is strictly valid for a plasma in a homogeneous and stationary magnetic field. In the '60, experiments have shown that this theory does not apply as a local theory of transport in Tokamaks. It was shown that global geometric characteristics of the confining elements have a strong influence on the transport. Three regimes of collisionality are characteristic of the neoclassical transport theory: the banana regime (the electronic diffusion coefficient increases starting from zero), the plateau regime (the diffusion coefficient is almost independent of the collisionality) and the Pfirsch-Schlueter regime (the electronic diffusion coefficient again increases with the collisionality)

  2. Electrostatic analysis of the tokamak edge plasma

    SciTech Connect

    Motley, R.W.

    1981-07-01

    The intrusion of an equipotential poloidal limiter into the edge plasma of a circular tokamak discharge distorts the axisymmetry in two ways: (1) it (partially) shorts out the top-to-bottom Pfirsch-Schlueter driving potentials, and (2) it creates zones of back current flow into the limiter. The resulting boundary mismatch between the outer layers and the inner axisymmetric Pfirsch-Schlueter layer provides free energy to drive the edge plasma unstable. Special limiters are proposed to symmetrize the edge plasma and thereby reduce the electrical and MHD activity in the boundary layer.

  3. Tokamak Equilibria with Reversed Current Density

    NASA Astrophysics Data System (ADS)

    Martynov, A. A.; Medvedev, S. Yu.; Villard, L.

    2003-08-01

    Observations of nearly zero toroidal current in the central region of tokamaks (the “current hole”) raises the question of the existence of toroidal equilibria with very low or reversed current in the core. The solutions of the Grad-Shafranov equilibrium equation with hollow toroidal current density profile including negative current density in the plasma center are investigated. Solutions of the corresponding eigenvalue problem provide simple examples of such equilibrium configurations. More realistic equilibria with toroidal current density reversal are computed using a new equilibrium problem formu­lation and computational algorithm which do not assume nested magnetic surfaces.

  4. Dust divertor for a tokamak fusion reactor

    SciTech Connect

    Tang, X Z; Delzanno, G L

    2009-01-01

    Micron-size tungsten particulates find equilibrium position in the magnetized plasma sheath in the normal direction of the divertor surface, but are convected poloidally and toroidally by the sonic-ion-flow drag parallel to the divertor surface. The natural circulation of dust particles in the magnetized plasma sheath can be used to set up a flowing dust shield that absorbs and exhausts most of the tokamak heat flux to the divertor. The size of the particulates and the choice of materials offer substantial room for optimization.

  5. Self-Organized Stationary States of Tokamaks

    SciTech Connect

    Jardin, S. C.; Ferraro, N.; Krebs, I.

    2015-11-17

    We demonstrate that in a 3D resistive magnetohydrodynamic (MHD) simulation, for some parameters it is possible to form a stationary state in a tokamak where a saturated interchange mode in the center of the discharge drives a near helical flow pattern that acts to non-linearly sustain the configuration by adjusting the central loop voltage through a dynamo action. This could explain the physical mechanism for maintaining stationary non-sawtoothing “hybrid” discharges, often referred to as “flux-pumping”.

  6. 3D MHD Simulations of Tokamak Disruptions

    NASA Astrophysics Data System (ADS)

    Woodruff, Simon; Stuber, James

    2014-10-01

    Two disruption scenarios are modeled numerically by use of the CORSICA 2D equilibrium and NIMROD 3D MHD codes. The work follows the simulations of pressure-driven modes in DIII-D and VDEs in ITER. The aim of the work is to provide starting points for simulation of tokamak disruption mitigation techniques currently in the CDR phase for ITER. Pressure-driven instability growth rates previously observed in simulations of DIIID are verified; Halo and Hiro currents produced during vertical displacements are observed in simulations of ITER with implementation of resistive walls in NIMROD. We discuss plans to exercise new code capabilities and validation.

  7. Calculation of rf current drive in tokamaks

    NASA Astrophysics Data System (ADS)

    Peysson, Y.; Decker, J.

    2008-11-01

    The toroidal plasma current is a key parameter for controlling MHD stability and fusion performances in tokamaks. Among the various methods for driving current, rf waves are a flexible and powerful tool. Therefore, their role in the design and optimization of advanced scenarios is considerable. The universal ray-tracing code C3PO coupled with the fully implicit linearized 3-D bounce-averaged relativistic electron Fokker-Planck solver LUKE is an illustration of the present day effort for performing fast and realistic calculations of the rf driven plasma current. The versatility of this tool is highlighted by simulations concerning the lower hybrid and electron cyclotron waves.

  8. Diamagnetic flux measurement in Aditya tokamak

    SciTech Connect

    Kumar, Sameer; Jha, Ratneshwar; Lal, Praveen; Hansaliya, Chandresh; Gopalkrishna, M. V.; Kulkarni, Sanjay; Mishra, Kishore

    2010-12-15

    Measurements of diamagnetic flux in Aditya tokamak for different discharge conditions are reported for the first time. The measured diamagnetic flux in a typical discharge is less than 0.6 mWb and therefore it has required careful compensation for various kinds of pick-ups. The hardware and software compensations employed in this measurement are described. We introduce compensation of a pick-up due to plasma current of less than 20 kA in short duration discharges, in which plasma pressure gradient is supposed to be negligible. The flux measurement during radio frequency heating is also presented in order to validate compensation.

  9. Tokamak physics experiment: Diagnostic windows study

    SciTech Connect

    Merrigan, M.; Wurden, G.A.

    1995-11-01

    We detail the study of diagnostic windows and window thermal stress remediation in the long-pulse, high-power Tokamak Physics Experiment (TPX) operation. The operating environment of the TPX diagnostic windows is reviewed, thermal loads on the windows estimated, and cooling requirements for the windows considered. Applicable window-cooling technology from other fields is reviewed and its application to the TPX windows considered. Methods for TPX window thermal conditioning are recommended, with some discussion of potential implementation problems provided. Recommendations for further research and development work to ensure performance of windows in the TPX system are presented.

  10. Anomalous thermal confinement in ohmically heated tokamaks

    SciTech Connect

    Romanelli, F.; Tang, W.M.; White, R.B.

    1986-02-01

    A model is proposed to explain the behavior of the gross energy confinement time in ohmically heated tokamak plasmas. The analysis takes into account the effect of the anomalous thermal conductivity due to small scale turbulence and of the macroscopic MHD behavior, which provides some constraints on the temperature profile. Results indicate that the thermal conductivity associated with the dissipative trapped-electron mode and with the ion temperature gradient (eta/sub i/) mode can account, respectively, for the Neo-Alcator scaling and the saturation of the energy confinement time with density. Comparisons with experimental results show reasonable agreement. 32 refs., 12 figs.

  11. Viscosity in the edge of tokamak plasmas

    NASA Astrophysics Data System (ADS)

    Stacey, W. M.

    1993-05-01

    A fluid representation of viscosity has been incorporated into a set of fluid equations that are maximally ordered in the 'short radial gradient scale length' (srgsl) ordering that is appropriate for the edge of tokamak plasmas. The srgsl ordering raises viscous drifts and other viscous terms to leading order and fundamentally alters the character of the fluid equations. A leasing order viscous drift is identified. Viscous-driven radial particle and energy fluxes in the scrape-off layer and divertor channel are estimated to have an order unity effect in reducing radial peaking of energy fluxes transported along the field lines to divertor collector plates.

  12. Equilibrium reconstruction in the START tokamak

    NASA Astrophysics Data System (ADS)

    Appel, L. C.; Bevir, M. K.; Walsh, M. J.

    2001-02-01

    The computation of magnetic equilibria in the START spherical tokamak is more difficult than those in more conventional large aspect ratio tokamaks. This difficulty arises partly as a result of the use of induction compression to generate high current plasma, as this precludes the positioning of magnetic diagnostics close to the outboard side of the plasma. In addition, the effect of a conducting wall with a high, but finite, conductivity must be included. A method is presented for obtaining plasma equilibrium reconstructions based on the EFIT code. New constraints are used to relate isoflux surface locations deduced from radial profile measurements of electron temperature. A model of flux diffusion through the vessel wall is developed. It is shown that neglecting flux diffusion in the vessel wall can lead to a significant underestimate in the calculation of the plasma βt. Using a relatively sparse set of magnetic signals, βt can be obtained to within a fractional error of +/-10%. Using constraints to relate isoflux surface locations, the principle involved in determining the internal q profile is demonstrated.

  13. Plasma transport in a compact ignition tokamak

    SciTech Connect

    Singer, C.E.; Ku, L.P; Bateman, G.

    1987-02-01

    Nominal predicted plasma conditions in a compact ignition tokamak are illustrated by transport simulations using experimentally calibrated plasma transport models. The range of uncertainty in these predictions is explored by using various models which have given almost equally good fits to experimental data. Using a transport model which best fits the data, thermonuclear ignition occurs in a Compact Ignition Tokamak design with major radius 1.32 m, plasma half-width 0.43 m, elongation 2.0, and toroidal field and plasma current ramped in six seconds from 1.7 to 10.4 T and 0.7 to 10 MA, respectively. Ignition is facilitated by 20 MW of heating deposited off the magnetic axis near the /sup 3/He minority cyclotron resonance layer. Under these conditions, sawtooth oscillations are small and have little impact on ignition. Tritium inventory is minimized by preconditioning most discharges with deuterium. Tritium is injected, in large frozen pellets, only after minority resonance preheating. Variations of the transport model, impurity influx, heating profile, and pellet ablation rates, have a large effect on ignition and on the maximum beta that can be achieved.

  14. Constrained ripple optimization of Tokamak bundle divertors

    SciTech Connect

    Hively, L.M.; Rome, J.A.; Lynch, V.E.; Lyon, J.F.; Fowler, R.H.; Peng, Y-K.M.; Dory, R.A.

    1983-02-01

    Magnetic field ripple from a tokamak bundle divertor is localized to a small toroidal sector and must be treated differently from the usual (distributed) toroidal field (TF) coil ripple. Generally, in a tokamak with an unoptimized divertor design, all of the banana-trapped fast ions are quickly lost due to banana drift diffusion or to trapping between the 1/R variation in absolute value vector B ..xi.. B and local field maxima due to the divertor. A computer code has been written to optimize automatically on-axis ripple subject to these constraints, while varying up to nine design parameters. Optimum configurations have low on-axis ripple (<0.2%) so that, now, most banana-trapped fast ions are confined. Only those ions with banana tips near the outside region (absolute value theta < or equal to 45/sup 0/) are lost. However, because finite-sized TF coils have not been used in this study, the flux bundle is not expanded.

  15. Physics evaluation of compact tokamak ignition experiments

    SciTech Connect

    Uckan, N.A.; Houlberg, W.A.; Sheffield, J.

    1985-01-01

    At present, several approaches for compact, high-field tokamak ignition experiments are being considered. A comprehensive method for analyzing the potential physics operating regimes and plasma performance characteristics of such ignition experiments with O-D (analytic) and 1-1/2-D (WHIST) transport models is presented. The results from both calculations are in agreement and show that there are regimes in parameter space in which a class of small (R/sub o/ approx. 1-2 m), high-field (B/sub o/ approx. 8-13 T) tokamaks with aB/sub o/S/q/sub */ approx. 25 +- 5 and kappa = b/a approx. 1.6-2.0 appears ignitable for a reasonable range of transport assumptions. Considering both the density and beta limits, an evaluation of the performance is presented for various forms of chi/sub e/ and chi/sub i/, including degradation at high power and sawtooth activity. The prospects of ohmic ignition are also examined. 16 refs., 13 figs.

  16. Magnetic diagnostics for the lithium tokamak experiment.

    PubMed

    Berzak, L; Kaita, R; Kozub, T; Majeski, R; Zakharov, L

    2008-10-01

    The lithium tokamak experiment (LTX) is a spherical tokamak with R(0)=0.4 m, a=0.26 m, B(TF) approximately 3.4 kG, I(P) approximately 400 kA, and pulse length approximately 0.25 s. The focus of LTX is to investigate the novel low-recycling lithium wall operating regime for magnetically confined plasmas. This regime is reached by placing an in-vessel shell conformal to the plasma last closed flux surface. The shell is heated and then coated with liquid lithium. An extensive array of magnetic diagnostics is available to characterize the experiment, including 80 Mirnov coils (single and double axis, internal and external to the shell), 34 flux loops, 3 Rogowskii coils, and a diamagnetic loop. Diagnostics are specifically located to account for the presence of a secondary conducting surface and engineered to withstand both high temperatures and incidental contact with liquid lithium. The diagnostic set is therefore fabricated from robust materials with heat and lithium resistance and is designed for electrical isolation from the shell and to provide the data required for highly constrained equilibrium reconstructions. PMID:19044600

  17. Modular pump limiter systems for large tokamaks

    NASA Astrophysics Data System (ADS)

    Uckan, T.; Klepper, C. C.; Mioduszewski, P. K.; McGrath, R. T.

    1987-09-01

    Long-pulse (greater than 10-s) operation of large tokamaks with high-power (greater than 10-MW) heating and extensive external fueling will require correspondingly efficient particle exhaust for density control. A pump limiter can provide the needed exhaust capability by removing a small percentage of the particles, which would otherwise be recycled. Single pump limiter modules have been operated successfully on ISX-B, PDX, TEXTOR, and PLT. An axisymmetric pump limiter is now being installed and will be studied in TEXTOR. A third type of pump limiter is a system that consists of several modules and exhibits performance different from that of a single module. To take advantage of the flexibility of a modular pump limiter system in a high-power, long-pulse device, the power load must be distributed among a number of modules. Because each added module changes the performance of all the others, a set of design criteria must be defined for the overall limiter system. The design parameters for the modules are then determined from the system requirements for particle and power removal. Design criteria and parameters are presented, and the impact on module design of the state of the art in engineering technolgy is discussed. The relationship between modules is considered from the standpoint of flux coverage and shadowing effects. The results are applied to the Tore Supra tokamak. A preliminary conceptual design for the Tore Supra pump limiter system is discussed, and the design parameters of the limiter modules are presented.

  18. The Spherical Tokamak MEDUSA for Costa Rica

    NASA Astrophysics Data System (ADS)

    Ribeiro, Celso; Vargas, Ivan; Guadamuz, Saul; Mora, Jaime; Ansejo, Jose; Zamora, Esteban; Herrera, Julio; Chaves, Esteban; Romero, Carlos

    2012-10-01

    The former spherical tokamak (ST) MEDUSA (Madison EDUcation Small Aspect.ratio tokamak, R<0.14m, a<0.10m, BT<0.5T, Ip<40kA, 3ms pulse)[1] is in a process of donation to Costa Rica Institute of Technology. The main objective of MEDUSA is to train students in plasma physics /technical related issues which will help all tasks of the very low aspect ratio stellarator SCR-1(A≡R/>=3.6, under design[2]) and also the ongoing activities in low temperature plasmas. Courses in plasma physics at undergraduate and post-graduate joint programme levels are regularly conducted. The scientific programme is intend to clarify several issues in relevant physics for conventional and mainly STs, including transport, heating and current drive via Alfv'en wave, and natural divertor STs with ergodic magnetic limiter[3,4]. [1] G.D.Garstka, PhD thesis, University of Wisconsin at Madison, 1997 [2] L.Barillas et al., Proc. 19^th Int. Conf. Nucl. Eng., Japan, 2011 [3] C.Ribeiro et al., IEEJ Trans. Electrical and Electronic Eng., 2012(accepted) [4] C.Ribeiro et al., Proc. 39^th EPS Conf. Contr. Fusion and Plasma Phys., Sweden, 2012

  19. System studies of compact ignition tokamaks

    SciTech Connect

    Galambos, J.D.; Peng, Y.K.M.; Blackfield, D.T.

    1986-01-01

    A new version of the FEDC Tokamak System Code (TSC) has been developed to analyze the Compact Ignition Tokamak (CIT). These proposed experiments have small (major radius F 1.5m) and high magnetic fields (B J 10T), and are characterized by reduced cost. Key design constraints of CIT include limits to the high stress levels in the magnetic coils, limits to the large temperature rises in the coils and on the first wall or divertor plate, minimizing power supply requirements, and assuring adequate plasma performance in fusion ignition and burn time consistent with the latest physics understanding. We present systems code level studies of CIT parameter space here for a range of design options with various design constraints. The present version of the TSC incorporates new models for key components of CIT. For example, new algorithms have been incorporated for calculating stress levels in the TFC and ohmic solenoid, temperature rise in the magnetic coils, peak power requirements, plasma MHD equilibrium and volt-second capability. The code also incorporates a numerical optimizer to find combinations of engineering quantities (device size, coil sizes, coil current densities etc.) and physics quantities (plasma density temperature, and beta, etc.) which satisfy all the constraints and can minimize or maximize a figure of merit (e.g., the major radius). This method was recently used in a mirror reactor system code (3) for the Minimara concept development.

  20. Superconducting CICC for SST-1 tokamak magnets

    SciTech Connect

    Pradhan, S.; Saxena, Y.C.

    1995-12-31

    The SST-1 tokamak is being designed for steady state operation with plasma durations in the range of 100--1,000s. Both the toroidal field coils (TFC) and the poloidal field coils (PFC) in the SST-1 tokamak are superconducting. TF coils are required to produce a magnetic field of 3 T at 1.05 m from machine axis. The maximum field seen by the TF coil conductor will be {le} 4.3 T. The cable for the TF coils has, therefore, been designed for a field of 5 T at the conductor. The PFC are used for plasma shaping and equilibrium and the magnetic field on the PFC conductor is estimated to be {le} 3.2 T. Hence a cable designed for 5 T operation will be suitable for PFC also subjected to the stability against the disturbances generated by the current ramping in the PFC. The authors have designed two Cable-in-conduit-conductor (CICC) type cables, one with copper conduit (to be preferably used with the TFC) and the other with Stainless Steel conduit to be used with PFC. They describe some design aspects of these cables and discuss the stability of these cables against disturbances.

  1. Critical issues for modeling dust transport in tokamaks.

    PubMed

    Bacharis, Minas; Coppins, Michael; Allen, John E

    2010-08-01

    Dust produced in tokamaks is an important issue for fusion. Dust particles can introduce health and safety issues when in the same time can have an impact on reactor performance. Apart from the associated problems there are also potential benefits that make the better understanding of their behavior important. In this work the dust transport code Dust in TOKamakS will be used to explore the effect that variations in the plasma background and the physical model, describing the plasma-dust interaction, have on their predicted trajectories. PMID:20866922

  2. /sup 3/He functions in tokamak-pumped laser systems

    SciTech Connect

    Jassby, D.L.

    1986-10-01

    /sup 3/He placed in an annular cell around a tokamak fusion generator can convert moderated fusion neutrons to energetic ions by the /sup 3/He(n,p)T reaction, and thereby excite gaseous lasants mixed with the /sup 3/He while simultaneously breeding tritium. The total /sup 3/He inventory is about 4 kg for large tokamak devices. Special configurations of toroidal-field magnets, neutron moderators and beryllium reflectors are required to permit nearly uniform neutron current into the laser cell with minimal attenuation. The annular laser radiation can be combined into a single output beam at the top of the tokamak.

  3. Nonneutralized charge effects on tokamak edge magnetohydrodynamic stability

    NASA Astrophysics Data System (ADS)

    Zheng, Linjin; Horton, W.; Miura, H.; Shi, T. H.; Wang, H. Q.

    2016-08-01

    Owing to the large ion orbits, excessive electrons can accumulate at tokamak edge. We find that the nonneutralized electrons at tokamak edge can contribute an electric compressive stress in the direction parallel to magnetic field by their mutual repulsive force. By extending the Chew-Goldburger-Low theory (Chew et al., 1956 [13]), it is shown that this newly recognized compressive stress can significantly change the plasma average magnetic well, so that a stabilization of magnetohydrodynamic modes in the pedestal can result. This linear stability regime helps to explain why in certain parameter regimes the tokamak high confinement can be rather quiet as observed experimentally.

  4. ECH by FEL and gyrotron sources on the Microwave Tokamak Experiment (MTX) tokamak

    SciTech Connect

    Stallard, B.W.; Turner, W.C.; Allen, S.L.; Byers, J.A.; Felker, B.; Fenstermacher, M.E.; Ferguson, S.W.; Hooper, E.G.; Thomassen, K.I.; Throop, A.L. ); Makowski, M.A. )

    1990-08-09

    The Microwave Tokamak Experiment (MTX) at LLNL is studying the physics of intense pulse ECH is a high-density tokamak plasma using a microwave FEL. Related technology development includes the FEL, a windowless quasi-optical transmission system, and other microwave components. Initial plasma experiments have been carried out at 140 GHz with single rf pulses generated using the ETA-II accelerator and the ELF wiggler. Peak power levels up to 0.2 GW and pulse durations up to 10 ns were achieved for injection into the plasma using as untapered wiggler. FEL pulses were transmitted over 33 m from the FEL to MTX using six mirrors mounted in a 50-cm-diam evacuated pipe. Measurements of the microwave beam and transmission through the plasma were carried out. For future rapid pulse experiments at high average power (4 GW peak power, 5kHz pulse rate, and {bar P} > 0.5 MW) using the IMP wiggler with tapered magnetic field, a gyrotron (140 GHz, 400 kW cw or up to 1 MW short pulse) is being installed to drive the FEL input or to directly heat the tokamak plasma at full gyrotron power. Quasi-optic techniques will be used to couple the gyrotron power. For direct plasma heating, the gyrotron will couple into the existing mirror transport system. Using both sources of rf generation, experiments are planned to investigate intense pulse absorption and tokamak physics, such as the ECH of a pellet-fueled plasma and plasma control using localized heating. 12 refs., 9 figs.

  5. A review of ELMs in divertor tokamaks

    SciTech Connect

    Hill, D.N.

    1996-05-23

    This paper reviews what is known about edge localized modes (ELMs), with an emphasis on their effect on the scrape-off layer and divertor plasmas. ELM effects have been measured in the ASDEX-U, C-Mod, COMPASS-D, DIII-D, JET, JFT-2M,JT-60U, and TCV tokamaks and are reported here. At least three types of ELMs have been identified and their salient features determined. Type-1 giant ELMs can cause the sudden loss of up to 10-15% of the plasma stored energy but their amplitude ({Delta}W/W) does not increase with increasing power. Type- 3 ELMs are observed near the H-mode power threshold and produce small energy dumps (1-3% of the stored energy). All ELMs increase the scrape- off layer plasma and produce particle fluxes on the divertor targets which are as much as ten times larger that the quiescent phase between ELMs. The divertor heat pulse is largest on the inner target, unlike that of L-Mode or quiescent H-mode; some tokamaks report radial structure in the heat flux profile which is suggestive of islands or helical structures. The power scaling of Type-1 ELM amplitude and frequency have been measured in several tokamaks and has recently been applied to predictions of the ELM Size in ITER. Concern over the expected ELM amplitude has led to a number of experiments aimed at demonstrating active control of ELMs. Impurity gas injection with feedback control on the radiation loss in ASDEX-U suggests that a promising mode of operation (the CDH-mode) with a very small type-3 ELMs can be maintained with heating power sell above the H-mode threshold, where giant type-1 ELMs can be maintained with heating power well above the H-mode threshold, where Giant type-1 ELMs are normally observed. While ELMs have many potential negative effects, the beneficial effect of ELMs in providing density control and limiting the core plasma impurity content in high confinement H- mode discharges should not be overlooked.

  6. Development of tokamak reactor system analysis code NEW-TORSAC

    NASA Astrophysics Data System (ADS)

    Kasai, Masao; Ida, Toshio; Nishikawa, Masana; Kameari, Akihisa; Nishio, Satoshi; Tone, Tatsuzo

    1987-07-01

    A systems analysis code named NEW-TORSAC (TOkamak Reactor Systems Analysis Code) has been developed by modifying the TORSAC which had been already developed by us. The NEW-TORSAC is available for tokamak reactor designs and evaluations from experimental machines to commercial reactor plants. It has functions to design tokamaks automatically from plasma parameter setting to determining configurations of reactor equipments and calculating main characteristics parameters of auxiliary systems and the capital costs. In the case of analyzing tokamak reactor plants, the code can calculate busbar energy costs. In addition to numerical output, some output of this code such as a reactor configuration, plasma equilibrium, electro-magnetic forces, etc., are graphically displayed. The code has been successfully applied to the scoping studies of the next generation machines and commercial reactor plants.

  7. Improvement of tokamak performance by injection of electrons

    SciTech Connect

    Ono, Masayuki

    1992-12-01

    Concepts for improving tokamak performance by utilizing injection of hot electrons are discussed. Motivation of this paper is to introduce the research work being performed in this area and to refer the interested readers to the literature for more detail. The electron injection based concepts presented here have been developed in the CDX, CCT, and CDX-U tokamak facilities. The following three promising application areas of electron injection are described here: 1. Non-inductive current drive, 2. Plasma preionization for tokamak start-up assist, and 3. Charging-up of tokamak flux surfaces for improved plasma confinement. The main motivation for the dc-helicity injection current drive is in its efficiency that, in theory, is independent of plasma density. This property makes it attractive for driving currents in high density reactor plasmas.

  8. Neutral beam injector performance on the PLT and PDX tokamaks

    SciTech Connect

    Schilling, G.; Ashcroft, D.L.; Eubank, H.P.; Grisham, L.R.; Kozub, T.A.; Kugel, H.W.; Rossmassler, J.; Williams, M.D.

    1981-02-01

    An overall injector system description is presented first, and this will be followed by a detailed discussion of those problems unique to multiple injector operation on the tokamaks, i.e., power transmission, conditioning, reliability, and failures.

  9. TFTR/JET INTOR workshop on plasma transport tokamaks

    SciTech Connect

    Singer, C.E.

    1985-01-01

    This report summarizes the proceedings of a Workshop on transport models for prediction and analysis of tokamak plasma confinement. Summaries of papers on theory, predictive modeling, and data analysis are included.

  10. Requirements for neutral beam current drive in tokamaks

    SciTech Connect

    Dory, R.A.

    1988-01-01

    This paper contains viewgraphs on the use of neutral beam current drive in future tokamaks. Current profiles, slowing down distributions, beam destabilization of alfven waves and plasma parameters are some items covered in this paper. (DWL)

  11. Heavy ion beam probe systems for tight aspect ratio tokamaks

    SciTech Connect

    Melnikov, A.V.; Zimeleva, L.G.; Krupnik, L.I.; Nedzelskij, I.S.; Trofimenko, Y.V.; Minaev, V.B.

    1997-01-01

    We discuss the specific features of the application of heavy ion beam probe (HIBP) systems to tight aspect ratio tokamaks. We present and compare the HIBP projects for the TUMAN-3, GLOBUS, and COMPASS, where the inner part of the plasma is not available for regular chord diagnostics, so the HIBP becomes very desirable. All existing tight aspect ratio facilities and projects have a low (less than 1.9 T) toroidal field that requires a comparatively low beam energy range. The natural elongation and triangularity in tight aspect ratio tokamaks require an accurate calculation of the three-dimensional magnetic field for probing optimization. In comparison with traditional tokamaks, the detector grids have a wider energy interval. In general, the trajectories and detector grids for tight aspect ratio tokamaks become similar to the stellarator ones. Traditional and new probing schemes are suggested and discussed. {copyright} {ital 1997 American Institute of Physics.}

  12. Reliability of initial-value MHD calculations of Tokamak disruptions

    NASA Astrophysics Data System (ADS)

    Hicks, H. R.; Carreras, B. A.; Garcia, L.; Holmes, J. A.

    1984-06-01

    The nonlinear coupling of resistive tearing modes was proposed as the mechanism for some Tokamak disruptions. This is based primarily on initial value resistive magnetohydrodynamic calculations performed with a finite difference grid in minor radius and Fourier series expansion in the poloidal and toroidal angles. The calculations show that, for certain q profiles, the nonlinear interaction of tearing modes of different helicities leads to the rapid destabilization of other modes. The resulting effects and the time scale are consistent with the Tokamak disruption.

  13. Neoclassical diffusion of heavy impurities in a rotating tokamak plasma

    SciTech Connect

    Wong, K.L.; Cheng, C.Z.

    1987-08-01

    Particle orbits in a rotating tokamak plasma are calculated from the equation of motion in the frame that rotates with the plasma. It is found that heavy particles in a rotating plasma can drift away from magnetic surfaces significantly faster, resulting in a diffusion coefficient much larger than that for a stationary plasma. Particle simulation is carried out and the results offer a qualitative explanation for some experimental data from the Tokamak Test Reactor (TFTR). 13 refs., 2 figs.

  14. Computer simulation of transport driven current in tokamaks

    NASA Astrophysics Data System (ADS)

    Nunan, W. J.; Dawson, J. M.

    1994-09-01

    We have investigated transport driven current in tokamaks via 2+1/2 dimensional, electromagnetic, particle-in-cell simulations. These have demonstrated a steady increase of toroidal current in centrally fueled plasmas. Neoclassical theory predicts that the bootstrap current vanishes at large aspect ratio, but we see equal or greater current growth in straight cylindrical plasmas. These results indicate that a centrally fueled and heated tokamak may sustain its toroidal current, even without the ``seed current'' which the neoclassical bootstrap theory requires.

  15. Design of a microwave calorimeter for the microwave tokamak experiment

    SciTech Connect

    Marinak, M. )

    1988-10-07

    The initial design of a microwave calorimeter for the Microwave Tokamak Experiment is presented. The design is optimized to measure the refraction and absorption of millimeter rf microwaves as they traverse the toroidal plasma of the Alcator C tokamak. Techniques utilized can be adapted for use in measuring high intensity pulsed output from a microwave device in an environment of ultra high vacuum, intense fields of ionizing and non-ionizing radiation and intense magnetic fields. 16 refs.

  16. Summer Research Experiences with a Laboratory Tokamak

    NASA Astrophysics Data System (ADS)

    Farley, N.; Mauel, M.; Navratil, G.; Cates, C.; Maurer, D.; Mukherjee, S.; Shilov, M.; Taylor, E.

    1998-11-01

    Columbia University's Summer Research Program for Secondary School Science Teachers seeks to improve middle and high school student understanding of science. The Program enhances science teachers' understanding of the practice of science by having them participate for two consecutive summers as members of laboratory research teams led by Columbia University faculty. In this poster, we report the research and educational activities of two summer internships with the HBT-EP research tokamak. Research activities have included (1) computer data acquisition and the representation of complex plasma wave phenomena as audible sounds, and (2) the design and construction of pulsed microwave systems to experience the design and testing of special-purpose equipment in order to achieve a specific technical goal. We also present an overview of the positive impact this type of plasma research involvement has had on high school science teaching.

  17. Argonne Plasma Engineering Experiment (APEX) Tokamak

    SciTech Connect

    Norem, J.H.; Balka, L.J.; Kulovitz, E.E.; Magill, S.R.; McGhee, D.G.; Moretti, A.; Praeg, W.F.

    1981-03-01

    The Argonne Plasma Engineering Experiment (APEX) Tokamak was designed to provide hot plasmas for reactor-relevant experiments with rf heating (current drive) and plasma wall experiments, principally in-situ low-Z wall coating and maintenance. The device, sized to produce energetic plasmas at minimum cost, is small (R = 51 cm, r = 15 cm) but capable of high currents (100 kA) and long pulse durations (100 ms). A design using an iron central core with no return legs, pure tension tapewound toroidal field coils, digital radial position control, and UHV vacuum technology was used. Diagnostics include monochrometers, x-ray detectors, and a microwave interferometer and radiometer for density and temperature measurements. Stable 100 ms shots were produced with electron temperatures in the range 500 to 1000 eV. Initial results included studies of thermal desorption and recoating of wall materials.

  18. Nonlinear lower hybrid modeling in tokamak plasmas

    SciTech Connect

    Napoli, F.; Schettini, G.; Castaldo, C.; Cesario, R.

    2014-02-12

    We present here new results concerning the nonlinear mechanism underlying the observed spectral broadening produced by parametric instabilities occurring at the edge of tokamak plasmas in present day LHCD (lower hybrid current drive) experiments. Low frequency (LF) ion-sound evanescent modes (quasi-modes) are the main parametric decay channel which drives a nonlinear mode coupling of lower hybrid (LH) waves. The spectrum of the LF fluctuations is calculated here considering the beating of the launched LH wave at the radiofrequency (RF) operating line frequency (pump wave) with the noisy background of the RF power generator. This spectrum is calculated in the frame of the kinetic theory, following a perturbative approach. Numerical solutions of the nonlinear LH wave equation show the evolution of the nonlinear mode coupling in condition of a finite depletion of the pump power. The role of the presence of heavy ions in a Deuterium plasma in mitigating the nonlinear effects is analyzed.

  19. DIII-D Advanced Tokamak Research Overview

    SciTech Connect

    V.S. Chan; C.M. Greenfield; L.L. Lao; T.C. Luce; C.C. Petty; G.M. Staebler

    1999-12-01

    This paper reviews recent progress in the development of long-pulse, high performance discharges on the DIII-D tokamak. It is highlighted by a discharge achieving simultaneously {beta}{sub N}H of 9, bootstrap current fraction of 0.5, noninductive current fraction of 0.75, and sustained for 16 energy confinement times. The physics challenge has changed in the long-pulse regime. Non-ideal MHD modes are limiting the stability, fast ion driven modes may play a role in fast ion transport which limits the stored energy and plasma edge behavior can affect the global performance. New control tools are being developed to address these issues.

  20. Toroidal microinstability studies of high temperature tokamaks

    SciTech Connect

    Rewoldt, G.; Tang, W.M.

    1989-07-01

    Results from comprehensive kinetic microinstability calculations are presented showing the effects of toroidicity on the ion temperature gradient mode and its relationship to the trapped-electron mode in high-temperature tokamak plasmas. The corresponding particle and energy fluxes have also been computed. It is found that, although drift-type microinstabilities persist over a wide range of values of the ion temperature gradient parameter /eta//sub i/ /equivalent to/ (dlnT/sub i//dr)/(dlnn/sub i//dr), the characteristic features of the dominant mode are those of the /eta//sub i/-type instability when /eta//sub i/ > /eta//sub ic/ /approximately/1.2 to 1.4 and of the trapped-electron mode when /eta//sub i/ < /eta//sub ic/. 16 refs., 7 figs.

  1. Transport Bifurcation in a Rotating Tokamak Plasma

    SciTech Connect

    Highcock, E. G.; Barnes, M.; Schekochihin, A. A.; Parra, F. I.; Roach, C. M.; Cowley, S. C.

    2010-11-19

    The effect of flow shear on turbulent transport in tokamaks is studied numerically in the experimentally relevant limit of zero magnetic shear. It is found that the plasma is linearly stable for all nonzero flow shear values, but that subcritical turbulence can be sustained nonlinearly at a wide range of temperature gradients. Flow shear increases the nonlinear temperature gradient threshold for turbulence but also increases the sensitivity of the heat flux to changes in the temperature gradient, except over a small range near the threshold where the sensitivity is decreased. A bifurcation in the equilibrium gradients is found: for a given input of heat, it is possible, by varying the applied torque, to trigger a transition to significantly higher temperature and flow gradients.

  2. Fast tomographic methods for the tokamak ISTTOK

    SciTech Connect

    Carvalho, P. J.; Coelho, R.; Neto, A.; Pereira, T.; Silva, C.; Fernandes, H.; Gori, S.; Toussaint, U. v.

    2008-04-07

    The achievement of long duration, alternating current discharges on the tokamak IST-TOK requires a real-time plasma position control system. The plasma position determination based on magnetic probes system has been found to be inadequate during the current inversion due to the reduced plasma current. A tomography diagnostic has been therefore installed to supply the required feedback to the control system. Several tomographic methods are available for soft X-ray or bolo-metric tomography, among which the Cormack and Neural networks methods stand out due to their inherent speed of up to 1000 reconstructions per second, with currently available technology. This paper discusses the application of these algorithms on fusion devices while comparing performance and reliability of the results. It has been found that although the Cormack based inversion proved to be faster, the neural networks reconstruction has fewer artifacts and is more accurate.

  3. Decommissioning of the Tokamak Fusion Test Reactor

    SciTech Connect

    E. Perry; J. Chrzanowski; C. Gentile; R. Parsells; K. Rule; R. Strykowsky; M. Viola

    2003-10-28

    The Tokamak Fusion Test Reactor (TFTR) at the Princeton Plasma Physics Laboratory was operated from 1982 until 1997. The last several years included operations with mixtures of deuterium and tritium. In September 2002, the three year Decontamination and Decommissioning (D&D) Project for TFTR was successfully completed. The need to deal with tritium contamination as well as activated materials led to the adaptation of many techniques from the maintenance work during TFTR operations to the D&D effort. In addition, techniques from the decommissioning of fission reactors were adapted to the D&D of TFTR and several new technologies, most notably the development of a diamond wire cutting process for complex metal structures, were developed. These techniques, along with a project management system that closely linked the field crews to the engineering staff who developed the techniques and procedures via a Work Control Center, resulted in a project that was completed safely, on time, and well below budget.

  4. Cooldown of the Compact Ignition Tokamak

    SciTech Connect

    Keeton, D.C.

    1987-08-01

    Cooldown of the Compact Ignition Tokamak (CIT) with the baseline liquid nitrogen cooling system was analyzed. On the basis of this analysis and present knowledge of the two-phase heat transfer, the current baseline CIT can be cooled down in about 1.5 h. An extensive heat transfer test program is recommended to reduce uncertainty in the heat transfer performance and to explore methods for minimizing the cooldown time. An alternate CIT cooldown system is described which uses a pressurized gaseous helium coolant in a closed-loop system. It is shown analytically that this system will cool down the CIT well within 1 h. Confidence in this analysis is sufficiently high that a heat transfer test program would not be necessary. The added cost of this alternate system is estimated to be about $5.3 million. This helium cooling system represents a reasonable backup approach to liquid nitrogen cooling of the CIT. 3 refs., 12 figs., 3 tabs.

  5. Radiation power measurement on the ADITYA tokamak

    NASA Astrophysics Data System (ADS)

    Tahiliani, Kumudni; Jha, Ratneshwar; Gopalkrishana, M. V.; Doshi, Kalpesh; Rathod, Vipal; Hansalia, Chandresh; ADITYA Team

    2009-08-01

    The radiation power loss and its variation with plasma density and current are studied in the ADITYA tokamak. The radiation power loss varies from 20% to 40% of the input power for different discharges. The radiation fraction decreases with increasing plasma current but it increases with increasing line-averaged central density. The radiated power behavior has also been studied in discharges with short pulses of molecular beam injection (MBI) and gas puff (GP). The increase in radiation loss is limited to the edge chords in the case of GP, but it extends to the core region for MBI fueling. The MBI seems to indicate reduction in the edge recycling. It is observed that during the density limit disruption, the radiated power loss is more in the current quench phase as compared with the thermal quench phase and comes mainly from the plasma edge.

  6. 'Snowflake' H Mode in a Tokamak Plasma

    SciTech Connect

    Piras, F.; Coda, S.; Duval, B. P.; Labit, B.; Marki, J.; Moret, J.-M.; Pitzschke, A.; Sauter, O.; Medvedev, S. Yu.

    2010-10-08

    An edge-localized mode (ELM) H-mode regime, supported by electron cyclotron heating, has been successfully established in a 'snowflake' (second-order null) divertor configuration for the first time in the TCV tokamak. This regime exhibits 2 to 3 times lower ELM frequency and 20%-30% increased normalized ELM energy ({Delta}W{sub ELM}/W{sub p}) compared to an identically shaped, conventional single-null diverted H mode. Enhanced stability of mid- to high-toroidal-mode-number ideal modes is consistent with the different snowflake ELM phenomenology. The capability of the snowflake to redistribute the edge power on the additional strike points has been confirmed experimentally.

  7. Status of ECRH project on EAST Tokamak

    NASA Astrophysics Data System (ADS)

    Wang, Xiaojie; Liu, Fukun; Shan, Jiafang; Xu, Handong; Wu, Dajun; Li, Bo; Zhang, Jiang; Huang, Yiyun; Wei, Wei; Tang, Yunying; Xu, Weiye; Hu, Huaichuan; Wang, Jian; Xu, Li

    2014-02-01

    A 140GHz electron cyclotron resonance heating and current drive (EC H&CD) project for EAST Tokamak is launched in 2011 with a total power of 4MW and pulse length of 100 s. The main objectives of the system are to provide central H&CD, assist start-up and control of MHD activities. The system comprises four gyrotrons each with nominal output power of 1MW at 140GHz. The RF power, transmitted through four evacuated corrugated waveguides will be injected into plasma from the low field side (radial port). The front steering equatorial launcher directs the RF beam over ±25° toroidally and scans over 38° poloidally. At present, the construction of the first 1MW system is undergoing for the expected campaign in the end of 2013. In this paper, the current status of the development and the design of the 140-GHz ECRH system are presented.

  8. Status of ECRH project on EAST Tokamak

    SciTech Connect

    Wang, Xiaojie; Liu, Fukun; Shan, Jiafang; Xu, Handong; Wu, Dajun; Li, Bo; Zhang, Jiang; Huang, Yiyun; Tang, Yunying; Xu, Weiye; Hu, Huaichuan; Wang, Jian; Xu, Li; Wei, Wei

    2014-02-12

    A 140GHz electron cyclotron resonance heating and current drive (EC H and CD) project for EAST Tokamak is launched in 2011 with a total power of 4MW and pulse length of 100 s. The main objectives of the system are to provide central H and CD, assist start-up and control of MHD activities. The system comprises four gyrotrons each with nominal output power of 1MW at 140GHz. The RF power, transmitted through four evacuated corrugated waveguides will be injected into plasma from the low field side (radial port). The front steering equatorial launcher directs the RF beam over ±25° toroidally and scans over 38° poloidally. At present, the construction of the first 1MW system is undergoing for the expected campaign in the end of 2013. In this paper, the current status of the development and the design of the 140-GHz ECRH system are presented.

  9. Instrumentation and controls of an ignited tokamak

    SciTech Connect

    Becraft, W.R.; Golzy, J.; Houlberg, W.A.; Kukielka, C.A.; Onega R.J.; Raju, G.V.S.; Stone, R.S.

    1980-10-01

    The instrumentation and controls (I and C) of an ignited plasma magnetically confined in a tokamak configuration needs increased emphasis in the following areas: (1) physics implications for control; (2) plasma shaping/position control; and (3) control to prevent disruptive instabilities. This document reports on the FY 1979 efforts in these and other areas. Also presented are discusssions in the areas of: (1) diagnostics suitable for the Engineering Test Facility (ETF); and (2) future research and development (R and D) needs. The appendices focus attention on some preliminary ideas about the measurement of the deuteron-triton (D-T) ratio in the plasma, synchrotron radiation, and divertor control. Finally, an appendix documenting the thermal consequences to the first wall of a MPD is presented.

  10. Stability of tearing modes in tokamak plasmas

    SciTech Connect

    Hegna, C.C.; Callen, J.D.

    1994-02-01

    The stability properties of m {ge} 2 tearing instabilities in tokamak plasmas are analyzed. A boundary layer theory is used to find asymptotic solutions to the ideal external kink equation which are used to obtain a simple analytic expression for the tearing instability parameter {Delta}{prime}. This calculation generalizes previous work on this topic by considering more general toroidal equilibria (however, toroidal coupling effects are ignored). Constructions of {Delta}{prime} are obtained for plasmas with finite beta and for islands that have nonzero width. A simple heuristic estimate is given for the value of the saturated island width when the instability criterion is violated. A connection is made between the calculation of the asymptotic matching parameter in the finite beta and island width case to the nonlinear analog of the Glasser effect.