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Locally Identified Promising Educational Practices 1977.  

ERIC Educational Resources Information Center

This booklet is the fourth in a series of annual publications that list and describe a wide array of promising and innovative educational practices in hopes of stimulating the development of alternative educational delivery systems and strategies involving students, teachers, administrators, and parents. Included in the booklet are brief…

Michigan State Dept. of Education, Lansing.


Locally Identified Promising Educational Practices 1975.  

ERIC Educational Resources Information Center

This booklet is the third in a series of annual publications that list and describe a wide array of promising and innovative educational practices in hopes of stimulating the development of alternative educational delivery systems and strategies involving students, teachers, administrators, and parents. Included in the booklet are brief…

Michigan State Dept. of Education, Lansing.


Locally Identified Promising Educational Practices 1974.  

ERIC Educational Resources Information Center

This booklet is the second in a series of annual publications that list and describe a wide array of promising and innovative educational practices in hopes of stimulating the development of alternative educational delivery systems and strategies involving students, teachers, administrators, and parents. Included in the booklet are brief…

Michigan State Dept. of Education, Lansing.


Provenance: Promise and Practice  

NASA Astrophysics Data System (ADS)

Capturing provenance is one of the fundamental principles of archive theory. Provenance consists of information about the creation of an object, its ownership, and how this information has changed over time. The data management community has been discussing how to apply the concepts of provenance to science data. Considerable attention has been paid to developing mechanisms to record how data were created, since this is key to reproducing research results. Less attention has been paid to the other elements of provenance, even though data and the organizations that archive data are dynamic and ever changing. Some practice is coming into play; but there is a large gap between theory and practice. This talk will review the current state of the art, discuss the gap between theory and practice, and describe what could be done to close the gap.

Duerr, R. E.



A Grounded Theory for Identifying Students with Emotional Disturbance: Promising Practices for Assessment, Intervention, and Service Delivery  

ERIC Educational Resources Information Center

A qualitative grounded theory study examined how practicing professionals involved in the ED identification process reconstructed the category of "emotional disturbance" as it applied to students in an alternative educational setting. A grounded theory integrates six emergent themes and essentially reframes the existing ED criteria in contemporary…

Barnett, Dori



Promising Practices: Teaching the Disadvantaged Gifted.  

ERIC Educational Resources Information Center

Intended for teachers, the document offers 10 articles on educating the disadvantaged gifted student. Included are the following titles: "Four Promising Practices for Teaching Gifted Disadvantaged Students" (which describes a workshop with problem solving and creative expressive activities) by E. Paul Torrance; "Cultural Diversity and the…

Miley, James F., Comp.; And Others


Promising Practices in Drug Treatment: Findings from Latin America  

ERIC Educational Resources Information Center

In a study to evaluate the drug treatment and aftercare efforts sponsored by the State Department's International Narcotics and Law Enforcement Affairs Bureau, residential Therapeutic Community (TC) treatment programs in three Latin American countries--Brazil, Peru and Argentina--were examined to identify promising practices and to assess lessons…

Nemes, Susanna; Libretto, Salvatore; Garrett, Gerald; Johansson, Anna Carin; Hess, Lauren



Using Multimedia to Introduce Your Promising Practice. Supported Education: A Promising Practice. Evidence-Based Practices KIT (Knowledge Informing Transformation)  

ERIC Educational Resources Information Center

Supported Education is a promising practice that helps people with mental illnesses who are interested in education and training return to school. Current research shows that Supported Education has demonstrated results. While more research is needed, Supported Education services show promise of becoming an evidence-based practice. Education…

Unger, Karen V.



Resistance Training: Identifying Best Practices.  

National Technical Information Service (NTIS)

Resistance training increases muscle strength. Muscle strength gains are influenced by program design. This review attempted to identify design choices that would be best practices. A best practice is a design option that produces significantly better res...

A. C. Barnard J. R. Vickers L. K. Hervig



What If? Promising Practices for Improving Schools  

ERIC Educational Resources Information Center

Today, there is little deviation from the standard, business-as-usual practices in the world of education. This book challenges these stale practices and asks the important questions that can improve schools beyond the current state of mediocrity. Written for administrators, supervisors, teachers, parents--even politicians and corporate…

Dunn, Rita, Ed.; Griggs, Shirley A., Ed.



Delivering on the Promise: Positive Practices for Immigrant Students.  

ERIC Educational Resources Information Center

This report highlights selected schools and their collaborative efforts in pulling educators, families, and communities together to support a particular school's success and the well-being of its immigrant students. The report documents promising practices, but also places these efforts in broader contexts, both practical and theoretical. These…

National Coalition of Advocates for Students, Boston, MA.


Promising Practices for Connecting High School to the Real World.  

ERIC Educational Resources Information Center

This monograph, containing 24 articles by 11 authors, describes a number of practices that have shown promise for better connecting high school with the broader world beyond school. The monograph begins with "Connecting High School with the Real World" (Sandi Harwell, William Blank), which discusses the concept of "real life" and various ways of…

Blank, W. E., Ed.; Harwell, Sandra, Ed.


The Four Cs of Promising Practices in Community Colleges  

ERIC Educational Resources Information Center

To address the achievement or opportunity gap of underrepresented populations in community colleges, this qualitative field methods study investigated five California community college programs that have demonstrated progress in improving (or show significant potential to improve) student achievement. This research found that promising practices

Haberler, Zachary; Levin, John S.



Lessons Learned from 51 Effective Youth Employment Initiatives. PEPNet '99 Promising and Effective Practices Network.  

ERIC Educational Resources Information Center

This book presents lessons learned after 4 years of Promising and Effective Practices Network (PEPNet), a project of the National Youth Employment Coalition that identifies and promotes criteria of effective practice in youth employment and development. The book, which provides a cumulative summary of all PEPNet programs, is a resource that brings…

National Youth Employment Coalition, Washington, DC.


Contexts for Promise: Noteworthy Practices and Innovations in the Identification of Gifted Students.  

ERIC Educational Resources Information Center

This monograph contains 11 papers describing model projects that address the identification of gifted students. An introduction by Carolyn M. Callahan and Carol A. Tomlinson identifies commonalities and themes in the promising practices highlighted in the papers. The papers include: (1) "Project STREAM: Support, Training and Resources for…

Callahan, Carolyn M., Ed.; And Others


The Recipe for Promising Practices in Community Colleges  

ERIC Educational Resources Information Center

This study identifies and examines the key practices of California community college programs that have demonstrated success in improving (or that have shown significant potential to improve) the achievement of underrepresented groups whose educational attainment often lags behind the attainment of relatively well-off White students. Unlike many…

Levin, John S.; Cox, Elizabeth M.; Cerven, Christine; Haberler, Zachary



Uncovering promising management practices from national Centers for Independent Living  

Microsoft Academic Search

This paper summarizes the second in a series of two research studies completed by the Rehabilitation Research and Training Center (RRTC) on Independent Living Management (ILM). The study identified management practices potentially effective for the organizational context of Centers for Independent Living (CILs) by \\

Vathsala I. Stone; Stephen M. Bauer; Mark E. Montgomery; Douglas J. Usiak


Identifying Unethical Practices in Journal Publishing  

Microsoft Academic Search

UNETHICAL JOURNAL PRACTICES have received extensive analysis in opinion pieces. However, research studies are few in number and limited in design. This article identifies unethical practices of authors, editors, and reviewers, with attention given to current concerns and proposals for eliminating misconduct.




Getting Started with Evidence-Based and Promising Practices. Supported Education: A Promising Practice. Evidence-Based Practices KIT (Knowledge Informing Transformation)  

ERIC Educational Resources Information Center

Within a system, change affects stakeholders differently. Consequently, when making changes in the mental health system, mental health agencies should expect varied reactions from staff, community members, consumers, and families. Since misunderstandings can stymie efforts to implement evidence-based and promising practices, it is important to…

Unger, Karen V.



Facilitating improvement in primary care: the promise of practice coaching.  


Practice coaching, also called practice facilitation, assists physician practices with the desire to improve in such areas as patient access, chronic and preventive care, electronic medical record use, patient-centeredness, cultural competence, and team-building. This issue brief clarifies the essential features of practice coaching and offers guidance for health system leaders, public and private insurers, and federal and state policymakers on how best to structure and design these programs in primary care settings. Good-quality evidence demonstrates that practice coaching is effective. The authors argue that primary care delivery in the United States would benefit from a more systematic approach to the training and deployment of primary care practice coaches. PMID:22712103

Grumbach, Kevin; Bainbridge, Emma; Bodenheimer, Thomas



Promising Practices in Statewide Articulation and Transfer Systems  

ERIC Educational Resources Information Center

This guide is based on a study funded by Lumina Foundation for Education and conducted by Hezel Associates and the Western Interstate Commission for Higher Education (WICHE). Designed to aid policymakers and others, this report takes a state-by-state look at practices related to transfer and articulation between two- and four-year public…

Hezel Associates (NJ1), 2010



The Practice and Promise of Prison Programming. Research Report.  

ERIC Educational Resources Information Center

This study focused on employment-related programs in prison, exploring what the research literature tells about the effectiveness of prison-based education, vocational training, and prison industry on postrelease outcomes. Also studied was the state of practice of such programs and strategic opportunities for improving existing employment-related…

Lawrence, Sarah; Mears, Daniel P.; Dubin, Glenn; Travis, Jeremy


Minorities and Women in Government: Practice Versus Promise.  

ERIC Educational Resources Information Center

In 1973, the Rhode Island Advisory Committee to the U.S. Commission on Civil Rights initiated a comprehensive project to review equal employment opportunity (EEO) in State and selected local government bodies in Rhode Island. In its project, the Advisory Committee examined employment practices and affirmative action efforts to recruit, hire, and…

Ericksen, Charles A., Ed.; And Others


Wikis for Knowledge Management: Business Cases, Best Practices, Promises, & Pitfalls  

Microsoft Academic Search

This chapter describes how wikis and related tools can be used for knowledge management (KM), and describes processes and best practices for creating and deploying wiki-based KM systems. In particular, we consider the business cases from multiple perspectives, including: participating in KM systems; initiating KM projects; and developing wiki platforms. Thus, the chapter seeks to help readers understand what KM

Clif Kussmaul; Roger Jack


Anatomy of Professional Practice: Promising Research Perspectives on Educational Leadership  

ERIC Educational Resources Information Center

This is the first book to bring into focus the full scope of professional practice in educational leadership. This book probes the limitations of traditional research in fully comprehending the true nature of leadership, and points out how future research must be expanded to deal with understanding the complexity of educational leadership…

English, Fenwick W.



Development of a Contextualized ESL Bridge Curriculum. Promising Practice  

ERIC Educational Resources Information Center

Black Hawk College (BHC) is a comprehensive community college serving all or part of nine counties and a population of approximately 224,510 residents in a mostly rural area of north-west Illinois. This practice was fully developed and implemented for the Shifting Gears (SG) initiative during the 2007-08 academic years. Heeding BHC's strategic…

Office of Community College Research and Leadership, 2010



The Promise of Mindfulness for Clinical Practice Education  

Microsoft Academic Search

This article reviews the recent trend in mindfulness-based psychotherapies and explores the utility of mindfulness training for clinical practice education. It presents the current literature and evidence suggesting that mindfulness training may provide a vehicle to foster essential clinical skills and attitudes, increase self-care and reduce the impact of occupational stress, and prepare students to understand and use mindfulness-based interventions

Annemarie Gockel



Engaging Women in Computer Science and Engineering: Promising Practices for Promoting Gender Equity in Undergraduate Research Experiences  

ERIC Educational Resources Information Center

Building on research that identifies and addresses issues of women's underrepresentation in computing, this article describes promising practices in undergraduate research experiences that promote women's long-term interest in computer science and engineering. Specifically, this article explores whether and how REU programs include programmatic…

Kim, Karen A.; Fann, Amy J.; Misa-Escalante, Kimberly O.



Puzzles and Pieces in Wonderland: The Promise and Practice of Student Affairs Research.  

ERIC Educational Resources Information Center

This monograph considers student affairs research, providing an overview of research issues; a practical guide to conducting and teaching about research; and a critique of current research assumptions, methods, and practices. "The Promise of Student Affairs Research" (Karl Beeler and Deborah Ellen Hunter) uses "Alice's Adventures in Wonderland" as…

Beeler, Karl J., Ed.; Hunter, Deborah Ellen, Ed.


Identifying domestic violence in primary care practice  

Microsoft Academic Search

OBJECTIVE: To improve detection of domestic violence as a problem for women seeking primary care, we compared the addition of a single\\u000a question about domestic violence on an existing self-administered health history form, to discretionary inquiry alone. We\\u000a studied 689 consecutive new women patients in an internal medicine practice. Domestic violence identification rose from 0%\\u000a in the control group with

Karen M. Freund; Sharon M. Bak; Leslie Blackhall



Promising Practices in Dropout Prevention and Transition for Students with Mild Disabilities.  

ERIC Educational Resources Information Center

Using a Delphi approach, 10 experts identified 186 practices from the fields of transition and dropout prevention that would be effective with high-risk students, including those with mild disabilities. Rating these practices indicates that many prevention practices are important and feasible to implement. (SLD)

Repetto, Jeanne B.; Pankaskie, Sara C.; De Palma-Hankins, Anne; Schwartz, Stuart E.; Perry, Laura



Best Practices for Identifying Gifted Students  

ERIC Educational Resources Information Center

Parents often go to principals to ask for help in supporting their gifted children. They may request acceleration for their child in mathematics, a specialized curriculum or course, extracurricular activities, a pullout program, or even a different teacher. Since misconceptions about identifying gifted students are prevalent, it's important that…

Johnsen, Susan K.



Educating Emotionally Disturbed Children--Promising Practices. Journal within a Journal.  

ERIC Educational Resources Information Center

Seven articles by educators with a variety of perspectives examine promising educational practices for use with children having emotional disturbances. Lee Bell offers strategies for using group activities in "All Together Now: Group Techniques for Teaching Students with Emotional Disturbances." Lyn Sarda and Rik Flynn discuss benefits and…

Michael, Robert, Ed.



Technology in the Classroom: Practice and Promise in the 21st Century. TESOL Professional Papers #2.  

ERIC Educational Resources Information Center

The discussion of technology in the classroom, particularly for second language instruction, looks at: current practices in technology-enhanced schoolrooms or learning centers; benefits and liabilities of technology-mediated language learning; and the as yet unrealized promise of computer-assisted language learning for the student and the teacher.…

Hanson-Smith, Elizabeth


Excellence and Equity for Language Minority Students: Critical Issues and Promising Practices.  

ERIC Educational Resources Information Center

The chapters in this collection provide the reader with a unified and systemic framework in which issues of excellence and equity are presented and discussed. The publication is structured to address critical issues and promising practices for linguistically and culturally diverse students in the areas of instruction, assessment, and parent…

Basterra, Maria del Rosario, Ed.


Seeing is Believing: Promising Practices for How School Districts Promote Family Engagement. Issue Brief  

ERIC Educational Resources Information Center

Harvard Family Research Project (HFRP) and the National Parent-Teacher Association (PTA) have teamed up to bring you a ground-breaking policy brief that examines the role of school districts in promoting family engagement. "Seeing is Believing: Promising Practices for How School Districts Promote Family Engagement" spotlights how six school…

Westmoreland, Helen; Rosenberg, Heidi M.; Lopez, M. Elena; Weiss, Heather



Education for Civic Engagement in Democracy: Service Learning and Other Promising Practices.  

ERIC Educational Resources Information Center

This collection of essays and references addresses the problem of the disengagement in public affairs and politics by U.S. youth and young adults. The collection brings together evidence of youth disengagement and reports on promising practices for civic education. Several chapters are devoted to research findings on the impact of service and…

Mann, Sheilah, Ed.; Patrick, John J., Ed.


Guiding Principles for Promising Female Programming: An Inventory of Best Practices.  

ERIC Educational Resources Information Center

This report describes practical policy and program development processes and promising program models for preventing and treating female delinquency. The report also provides a profile of female juvenile offenders, the problems they present, their needs, and the need to address them. More girls are entering the juvenile justice system, and it…

Northwest Regional Educational Lab., Portland, OR.


The Evidence. Supported Education: A Promising Practice. Evidence-Based Practices KIT (Knowledge Informing Transformation)  

ERIC Educational Resources Information Center

Supported Employment is an evidence-based practice that helps people with mental illness find and keep meaningful jobs in the community. Given these outcomes the challenge for Supported Employment programs is to rethink the emphasis on immediate work for everyone and help consumers utilize appropriate education and training opportunities available…

Unger, Karen V.



Long-Term Care in the United States: Policy Themes and Promising Practices  

Microsoft Academic Search

This analysis provides an overview of the major policy themes and promising practices emerging in recent years as policymakers and researchers struggle to design a long-term care system that meets the needs of an aging population. Themes that have dominated the long-term care policy debates include: recruiting and retaining a qualified long-term care workforce; devising financing mechanisms for those requiring

Amanda J. Lehning; Michael J. Austin



Identifying Balanced Action Learning: Cases of South Korean Practices  

ERIC Educational Resources Information Center

Despite considerable commitment to the application of action learning as leadership and organization development by a large number of Korean organizations, few identified empirical studies of action learning practices have been reported. The purpose of this study was to conduct case studies of South Korean action learning practices to examine…

Cho, Yonjoo; Bong, Hyeon-Cheol




EPA Science Inventory

The objectives of this report are to assess and synthesize current knowledge on three policy-science topics: ) Identify promising technologies and practices that could be utilized at technically suitable sites in the world to manage forests and agroforestry systems for sequesteri...


Fostering Resilience among Urban Youth Exposed to Violence: A Promising Area for Interdisciplinary Research and Practice  

ERIC Educational Resources Information Center

Most studies to date have examined negative effects of exposure to community violence, in line with the deficit-based perspective. However, given that most youth exposed to community violence demonstrate positive adaptation or resilience over time, we suggest a shift in perspective, practices, and policies across systems toward identifying and…

Jain, Sonia; Cohen, Alison K.



Assessment of promising forest-management practices and technologies for enhancing the conservation and sequestration of atmospheric carbon and their costs at the site level  

SciTech Connect

The objectives of the report are to assess and synthesize current knowledge on three policy-science topics: (1) Identify promising technologies and practices that could be utilized at technically suitable sites in the world to manage forests and agroforestry systems for sequestering and conserving carbon; (2) Assess available data on costs at the site level for promising forest and agroforestry management practices; and (3) Evaluate estimates of land technically suitable in forested nations and biomes of the world to help meet the Noordwijk forestation targets and the proposed Global Forest Agreement goals.

Dixon, R.K.; Schroeder, P.E.; Winjum, J.K.



VLSI Technology: Impact and Promise. Identifying Emerging Issues and Trends in Technology for Special Education.  

ERIC Educational Resources Information Center

As part of a 3-year study to identify emerging issues and trends in technology for special education, this paper addresses the implications of very large scale integrated (VLSI) technology. The first section reviews the development of educational technology, particularly microelectronics technology, from the 1950s to the present. The implications…

Bayoumi, Magdy


Response to Intervention (RtI) Model: a promising alternative for identifying students with learning disabilities?  


Until recently, in the United States, the traditional way to identify students with Specific Learning Disabilities (SLD) was through the discrepancy model where student IQs were compared to their level of achievement. However, educators and researchers alike have questioned this model as a means to define and identify students with SLD. The 2004 reauthorization of the Individuals with Disabilities Education Improvement Act (IDEIA) includes the use of response to intervention (RtI) as possible alternative to the intelligence-achievement discrepancy for identifying SLD. Core components of RtI include high-quality classroom instruction, universal screening, continuous progress monitoring, research-based interventions, and fidelity of instructional interventions. In Spain, the last publication of Ley Orgánica 2/2006, May 3, of Education (LOE) uses the term, Specific Learning Disabilities (SLD), in the chapter on students with specific needs of educational support. Some Autonomous Communities in Spain like the Canary Islands region are regulating SLD identification that adds RtI as an option to use in the eligibility process. Nevertheless, this model it is still at an embryonic stage and many issues are unresolved. While no special issue can cover all of these themes and issues, the contributions included in this monograph examine relevant aspects of this approach. Indeed, this special section is an attempt to introduce in Spain an approach that could be an alternative for identifying and intervening with students who have learning disabilities. PMID:21044534

Jiménez, Juan E



Partnership and measurement: the promise, practice and theory of a successful health social networking strategy.  


Patient health management (PHM) was launched as a promising paradigm to close care gaps, the inequities between usual and best care, for whole patient populations. PHM's core premise was that interventions of multidisciplinary, community-oriented partnerships that used repeated measurement and feedback of provider practices, clinical and economic outcomes and general communication of relevant health knowledge to all stakeholders would continuously make things better. This article reviews the evolution of PHM from its genesis in a series of casual hospital-based networks to its maturation in a province-wide, community-focused, clustered-lattice social network that facilitated the improved clinical and cost-efficient care and outcomes of whole patient populations. The factors underlying PHM's clinical and cost efficacy, specifically its patient-centric social networking structures and integral measurement and knowledge translation processes, offer continuing promise to optimally manage the care of our increasingly aged patient populations, with their high burden of chronic diseases and disproportionately large care gaps. In an era when patients are demanding and leading change, and governments are struggling fiscally, PHM's clinical efficacy and cost-efficiency are especially resonant. Things can be better. PMID:24863305

Montague, Terrence; Nemis-White, Joanna; Cochrane, Bonnie; Meisner, Janice; Trasler, Tessa



Australian Nurse Educators Identify Gaps in Expert Practice.  

ERIC Educational Resources Information Center

A Delphi panel of 28 Australian nurse educators and 42 clinicians identified 58 practice items in which reality was far from ideal. In particular, for 16 items related to patient empowerment, nursing research, and technology policy, clinical behavior was rated below the median. (SK)

Pelletier, Dianne; Duffield, Christine; Adams, Anne; Nagy, Sue; Crisp, Jackie; Mitten-Lewis, Suzanne



Innovations at Miami practice show promise for treating high-risk Medicare patients.  


Patients with five or more chronic conditions drive most Medicare costs. Our organization, ChenMed, developed a scalable primary care-led delivery model that focuses on this population while getting reimbursed through full-risk capitation by Medicare Advantage plans. ChenMed is a primary care-led group practice based in Florida that serves low-to-moderate-income elderly patients, largely through the Medicare Advantage program. Our model includes a number of innovations: a one-stop-shop approach for delivering multispecialty services in the community, smaller physician panel sizes of 350-450 patients that allow for intensive health coaching and preventive care, on-site physician pharmacy dispensing, a collaborative physician culture with peer review, and customized information technology. These innovations have improved patient medication adherence, increased the time doctors and patients spend together, and led to high rates of patient satisfaction. Additionally, our Medicare patients have substantially lower rates of hospital use than their peers in the Miami Medicare market. Creating chronic disease centers focused on seniors with multiple chronic conditions is a promising delivery system innovation with major potential to improve the cost and quality of care. PMID:23733982

Tanio, Craig; Chen, Christopher



Promising Practices in Wraparound for Children with Serious Emotional Disturbance and Their Families. Systems of Care: Promising Practices in Children's Mental Health 1998 Series. Volume IV.  

ERIC Educational Resources Information Center

This is the fourth volume in a series of monographs from the Comprehensive Community Mental Health Service for Children and Their Families Program, which currently supports 41 comprehensive system of care sites to meet the needs of children with serious emotional disturbances (SED). This volume identifies the essential elements of wraparound…

Burns, Barbara J., Ed.; Goldman, Sybil K., Ed.


The Promise of Technology for College Instruction: From Drill and Practice to Avatars  

ERIC Educational Resources Information Center

Technology and its uses have undergone significant change in the past several decades. Although the technology of 2010 has changed in ways unimaginable in 1960, the promise of technology today is similar to the promise of technology then. The achievement of student learning seems more likely to lie in the minds of the people who use the technology…

Kuhlenschmidt, Sally; Kacer, Barbara



The frontline clinical manager identifying direct reports' level of practice.  


Patricia Benner applied the Dreyfus Model of Skill Acquisition to describe and interpret skill acquisition and clinical judgment in nursing practice. Operational definitions for the 5 levels of her original Novice to Expert Theory were used by the study participants in a large Midwestern pediatric hospital to self-identify their level of practice. The frontline clinical managers of these direct care registered nurses (RNs) used the same tool to rate their direct reports. The aim of this portion of a larger study was to determine if the clinical manager's perception of their direct reports was the same as that of the RNs. The results of this study are being used by one study unit's clinical managers as the basis for implementing the Hersey and Blanchard Situational Leadership Model. The clinical managers work with their direct reports depending on the level of practice and the details of the task to be performed. One example is creating therapeutic relationships with each other and with families to ensure a safe environment for all. PMID:23934257

Longo, M Anne; Roussel, Linda; Pennington, Sandra L; Hoying, Cheryl



The Art of Collaboration: Promising Practices for Integrating the Arts and School Reform. AEP Research and Policy Brief  

ERIC Educational Resources Information Center

In June 2007, the Arts Education Partnership (AEP) convened the directors of eight collaborative entities to discuss promising practices for integrating the arts into the lives and curricula of urban public schools as a means of fostering system-wide educational improvement. The seven school-community collaboratives and one higher education…

Nelson, Andrew L.



Practical identifiability of finite mixtures of multivariate bernoulli distributions.  


The class of finite mixtures of multivariate Bernoulli distributions is known to be nonidentifiable; that is, different values of the mixture parameters can correspond to exactly the same probability distribution. In principle, this would mean that sample estimates using this model would give rise to different interpretations. We give empirical support to the fact that estimation of this class of mixtures can still produce meaningful results in practice, thus lessening the importance of the identifiability problem. We also show that the expectation-maximization algorithm is guaranteed to converge to a proper maximum likelihood estimate, owing to a property of the log-likelihood surface. Experiments with synthetic data sets show that an original generating distribution can be estimated from a sample. Experiments with an electropalatography data set show important structure in the data. PMID:10636936

Carreira-Perpinan, M A; Renals, S



Pursuing Promise Neighborhoods: With or without the Grant Program. A Center Policy & Practice Brief. Revised  

ERIC Educational Resources Information Center

The federal "Promise Neighborhoods" program underscores the importance of all children and youth having "access to great schools and strong systems of family and community support that will prepare them to attain an excellent education and successfully transition to college and a career." From this perspective, this brief stresses the importance…

Center for Mental Health in Schools at UCLA, 2012



How the practice of allergy shows the promise and challenge of personalized medicine.  


Personalized medicine seeks to stratify therapies according to individual characteristics, and by so doing improve effectiveness and reduce complications. However, there are not many models of care that is highly stratified within a single diagnosis in this manner. One potential model is the practice of allergy, in which care is tailored to specific allergens for individual patients within the broader context of care for rhinitis or asthma. Allergists have already confronted many of the same regulatory issues anticipated for personalized medicine. The history of allergy practice also anticipates some of the patient safety concerns that may arise from tracking and using highly personalized medical information. Finally, the therapy of allergy and asthma has been at the forefront of attempts to incorporate pharmacogenomics information into patient care. Individualized therapy has always been central to the practice of allergy, and so provides a useful proving ground for personalized medicine as a concept of care. PMID:21810545

McGhee, Sean A



The doctor of nursing practice and nursing education: highlights, potential, and promise.  


The success of the doctor of nursing practice (DNP) programs have exceeded everyone's expectations and resulted in increased interest in doctoral education in nursing. A shortage of doctorally prepared nurse educators continues to plague the profession and has a severe impact on the ability of schools of nursing to educate future generations of nurses. As a terminal degree in nursing practice, there is little focus on DNP graduates who are prepared as educators. To remedy this deficit, this article will therefore discuss and highlight (a) the significant potential of the DNP to mitigate the current nursing faculty shortage and to close the practice-education gap, (b) the specialized role of DNP graduates as educators and leaders in nursing education, and (c) the implications of the DNP for nursing scholarship. PMID:21925464

Danzey, Ida Maria; Ea, Emerson; Fitzpatrick, Joyce J; Garbutt, Susan J; Rafferty, Margaret; Zychowicz, Michael E



Innovative Contextualized Curriculum for a CNA to LPN Bridge Course. Promising Practice  

ERIC Educational Resources Information Center

As a pilot site selected to participate in Illinois' Shifting Gears (SG) initiative in 2007, Oakton Community College (OCC) partnered with Presbyterian Homes to develop a bridge course to prepare a cadre of their employed Certified Nursing Assistants (CNAs) to enter college-credit prerequisite courses to a Practical Nursing program. Oakton…

Office of Community College Research and Leadership, 2010



Looking for America, Volume 1. Promising School-Based Practices in Intergroup Relations.  

ERIC Educational Resources Information Center

This report presents results from a National Coalition of Advocates for Students' (NCAS) study (Looking for America) of intergroup relations between immigrant and U.S. born students in public schools and the organization's collaboration with selected schools to improve those relationships. The report reveals school practices designed to improve…

National Coalition of Advocates for Students, Boston, MA.


Supporting the Development of English Literacy in English Language Learners: Key Issues and Promising Practices.  

ERIC Educational Resources Information Center

This report summarizes research on the role of English oral proficiency in acquiring English literacy, noting issues that English language learners (ELLs) encounter because of their developing English oral proficiency and discussing best practices in supporting English language development in the context of literacy instruction for those students.…

August, Diane


Promising Practices to Meet Global Challenges in Science and Mathematics Education  

ERIC Educational Resources Information Center

The chapters in this book reflect the work of science and mathematics educators who have worked for many years at the international level. As members of the International Consortium for Research in Science and Mathematics Education, their work provides readers with issues, models, practices, and research results that have applicability and…

Berlin, Donna F., Ed.; White, Arthur L., Ed.




EPA Science Inventory

The assessment produced productivity and cost data for forest and agroforestry management practices in 94 nations. hat is, out of a total of 140 nations in the world with forest resources, about two-thirds are represented in the database at present. he total forest and woodland a...


Research-Practice Interactions as Reported in Recent Design Studies: Still Promising, Still Hazy  

ERIC Educational Resources Information Center

This study portrays recent research-practice connections found in 18 design research reports focusing on the creation of instructional solutions. Solutions in different stages of development varied greatly in duration, ranging from one lesson to a whole year curriculum, spanned all levels of education, many subjects (science, math, language,…

Ormel, Bart J. B.; Pareja Roblin, Natalie N.; McKenney, Susan E.; Voogt, Joke M.; Pieters, Jules M.



Identifying and Extinguishing Dysfunctional and Deadly Organizational Practices  

ERIC Educational Resources Information Center

It is possible to define an organization's culture in terms of its dominant behavioral practices and their molar consequences, from the shop floor to the executive suite (Redmon & Mason, 2001). Dysfunctional and potentially deadly practices (for the organization as a whole) can be "latent." They often go undetected until their dramatic…

Mawhinney, Thomas C.



Identifying Teacher Practices that Support Students' Explanation in Science  

Microsoft Academic Search

Abstract Teacher practices are essential for supporting students in scientific inquiry practices, such as the construction of scientific explanations. In this study, we examine whether four different teacher instructional strategies, defining scientific explanation, making the rational of scientific explanation explicit, modeling scientific explanation, and connecting scientific explanations to everyday explanations, influence students’ ability to construct scientific explanations during a middle

Katherine L. McNeill; David J. Lizotte; Joseph Krajcik


77 FR 4550 - Promising and Practical Strategies to Increase Postsecondary Success  

Federal Register 2010, 2011, 2012, 2013

...words or phrases--also known as ``keywords'' or meta data ``tags''--in...encourages respondents to this RFI to use keywords or tags to identify components of the...strategies described in their responses. The keywords or tags identified should be linked...



Collaborative supply chain management : The most promising practice for building efficient and sustainable supply chains  

Microsoft Academic Search

Purpose – The aim of this paper is to provide an overview of contemporary supply-chain management systems. Design\\/methodology\\/approach – The paper highlights the examples of state-of-the-art practice in supply-chain management, and speculates about where this movement is headed. Some of the collaborative supply chain management products generating the most interest will also be examined. Findings – Collaborative planning, forecasting and

Mohsen Attaran; Sharmin Attaran



77 FR 56194 - Promising and Practical Strategies to Increase Postsecondary Success; Request for Information  

Federal Register 2010, 2011, 2012, 2013

...strategy; and (4) Applicable keywords or tags (meta data tags...through federally supported research, evaluation, and sharing...phrases--also known as ``keywords'' or meta data ``tags...encourages respondents to use keywords or tags to identify...



Promising and Proven Substance Abuse Prevention Programs. Guide to Science-Based Practices.  

ERIC Educational Resources Information Center

For more than a decade, the Substance Abuse and Mental Health Services Administrations Center for Substance Abuse Prevention (CSAP) has supported demonstration programs designed to identify interventions that work with populations at high risk to prevent substance abuse, delay its onset, and reduce substance abuse-related behaviors. Research now…

Substance Abuse and Mental Health Services Administration (DHHS/PHS), Rockville, MD. Center for Substance Abuse Prevention.


Keeping Promises  

NASA Technical Reports Server (NTRS)

Commitments are between people, not schedules. Project management as practiced today creates a "commitment-free zone," because it assumes that people will commit to centrally managed schedules without providing a mechanism to ensure their work can be done. So they give it their best, but something always seems to come up ..."I tried, but you know how it is." This form of project management does not provide a mechanism to ensure that what should be done, can in fact be done at the required moment. Too often, promises reliable promise. made in coordination meetings are conditional and unreliable. It has been my experience that at times trust can be low and hard to build in this environment. The absence of reliable promises explains why on well-run projects, people are often only completing 30-50 percent of the deliverables they d promised for the week. We all know what a promise is; we have plenty of experience making them and receiving them from others. So what s the problem? The sad fact is that the project environment-like many other work environments- is often so filled with systemic dishonesty, that we don t expect promises that are reliable. Project managers excel when they manage their projects as networks of commitments and help their people learn to elicit and make reliable promises.

Howell, Gregory A.



Promise and dismay: The state of strategic environmental assessment systems and practices in Canada  

SciTech Connect

Has strategic environmental assessment (SEA) finally reached a point of maturity in Canada? Or, is it still stumbling to find its place in the impact assessment family? Strategic environmental assessment has been ongoing in Canada for a number of years, both formally and informally, and under a variety of labels and institutional models. The result is a system of SEA that is diverse, founded on a range of principles and frameworks, and not well understood. This paper provides a critical review of Canadian SEA systems and practices. To accomplish this objective, a manageable and diverse set of past and recent SEA and SEA-like frameworks and applications are described and critically analyzed based on a set of input, process, and output evaluation criteria. Results suggest considerable variability in SEA experience and value added. This is due in large part to the institutional and methodological pluralism of SEA, the boundaries of which are not well defined. Under the federal system, since the formalization of SEA, many applications have been disappointing in light of broader SEA good-practice principles and criteria. Indeed, some of the better examples of SEA have neither carried the SEA name tag nor occurred under formal SEA requirements. Further, many of the same challenges to project-based impact assessment also plague the development and value added of SEA. Of particular concern is the systematic separation of SEA from downstream decision inputs and assessment activities. As Canada commences review of its federal SEA Directive in preparation for the next generation of SEA, this paper reflects on what it has achieved in the prior.

Noble, Bram F. [Department of Geography, University of Saskatchewan, 117 Science Place, Saskatoon, Saskatchewan, S7N 5C8 (Canada)], E-mail:



Practical identifiability analysis of large environmental simulation models  

Microsoft Academic Search

Large environmental simulation models are usually overparameterized with respect to given sets of observations. This results in poorly identifiable or nonidentifiable model parameters. For small models, plots of sensitivity functions have proven to be useful for the analysis of parameter identifiability. For models with many parameters, however, near-linear dependence of sensitivity functions can no longer be assessed graphically. In this

Roland Brun; Peter Reichert; Hans R. Künsch



Identifying Techniques to determine the Overall Benchmarking Best Practices  

Microsoft Academic Search

This research study investigated the use of multiple attribute decision theory (MADT) as a more robust mechanism to determine the best-in-class performer when conducting a benchmarking analysis involving inventory record accuracy within a public sector warehouse. The traditional gap analysis technique only identifies the absolute best- in-class performer for a single performance metric. The MADT method uses multiple criteria to

James R. Oldham; Terry R. Collins; Manuel D. Rossetti; Heather L. Nachtmann


Promising Practices in CTS.  

ERIC Educational Resources Information Center

This document contains 85 articles taken from previously published issues of the "CTS Communication Network Update," a publication about the career and technology studies (CTS) program of career education designed for Alberta, Canada, high school juniors and seniors. Following an introductory section and a section on general CTS, the document…

Alberta Dept. of Education, Edmonton. Curriculum Standards Branch.


Can surveying practitioners about their practices help identify priority clinical practice guideline topics?  

Microsoft Academic Search

BACKGROUND: Clinical practice guidelines are systematically developed statements designed to assist in patient and physician clinical decision making for specific clinical circumstances. In order to establish which guideline topics are priorities, practitioners were surveyed regarding their current practice. METHODS: One hundred ninety-seven practitioners in Ontario, Canada were mailed a survey exploring their current practice or opinion regarding the prophylactic use

Melissa C Brouwers; Alexandra Chambers; James Perry



Genome Wide Association Study Identifies 20 Novel Promising Genes Associated with Milk Fatty Acid Traits in Chinese Holstein  

PubMed Central

Detecting genes associated with milk fat composition could provide valuable insights into the complex genetic networks of genes underling variation in fatty acids synthesis and point towards opportunities for changing milk fat composition via selective breeding. In this study, we conducted a genome-wide association study (GWAS) for 22 milk fatty acids in 784 Chinese Holstein cows with the PLINK software. Genotypes were obtained with the Illumina BovineSNP50 Bead chip and a total of 40,604 informative, high-quality single nucleotide polymorphisms (SNPs) were used. Totally, 83 genome-wide significant SNPs and 314 suggestive significant SNPs associated with 18 milk fatty acid traits were detected. Chromosome regions that affect milk fatty acid traits were mainly observed on BTA1, 2, 5, 6, 7, 9, 13, 14, 18, 19, 20, 21, 23, 26 and 27. Of these, 146 SNPs were associated with more than one milk fatty acid trait; most of studied fatty acid traits were significant associated with multiple SNPs, especially C18:0 (105 SNPs), C18 index (93 SNPs), and C14 index (84 SNPs); Several SNPs are close to or within the DGAT1, SCD1 and FASN genes which are well-known to affect milk composition traits of dairy cattle. Combined with the previously reported QTL regions and the biological functions of the genes, 20 novel promising candidates for C10:0, C12:0, C14:0, C14:1, C14 index, C18:0, C18:1n9c, C18 index, SFA, UFA and SFA/UFA were found, which composed of HTR1B, CPM, PRKG1, MINPP1, LIPJ, LIPK, EHHADH, MOGAT1, ECHS1, STAT1, SORBS1, NFKB2, AGPAT3, CHUK, OSBPL8, PRLR, IGF1R, ACSL3, GHR and OXCT1. Our findings provide a groundwork for unraveling the key genes and causal mutations affecting milk fatty acid traits in dairy cattle.

Li, Cong; Sun, Dongxiao; Zhang, Shengli; Wang, Sheng; Wu, Xiaoping; Zhang, Qin; Liu, Lin; Li, Yanhua; Qiao, Lv



Genome wide association study identifies 20 novel promising genes associated with milk Fatty Acid traits in chinese holstein.  


Detecting genes associated with milk fat composition could provide valuable insights into the complex genetic networks of genes underling variation in fatty acids synthesis and point towards opportunities for changing milk fat composition via selective breeding. In this study, we conducted a genome-wide association study (GWAS) for 22 milk fatty acids in 784 Chinese Holstein cows with the PLINK software. Genotypes were obtained with the Illumina BovineSNP50 Bead chip and a total of 40,604 informative, high-quality single nucleotide polymorphisms (SNPs) were used. Totally, 83 genome-wide significant SNPs and 314 suggestive significant SNPs associated with 18 milk fatty acid traits were detected. Chromosome regions that affect milk fatty acid traits were mainly observed on BTA1, 2, 5, 6, 7, 9, 13, 14, 18, 19, 20, 21, 23, 26 and 27. Of these, 146 SNPs were associated with more than one milk fatty acid trait; most of studied fatty acid traits were significant associated with multiple SNPs, especially C18:0 (105 SNPs), C18 index (93 SNPs), and C14 index (84 SNPs); Several SNPs are close to or within the DGAT1, SCD1 and FASN genes which are well-known to affect milk composition traits of dairy cattle. Combined with the previously reported QTL regions and the biological functions of the genes, 20 novel promising candidates for C10:0, C12:0, C14:0, C14:1, C14 index, C18:0, C18:1n9c, C18 index, SFA, UFA and SFA/UFA were found, which composed of HTR1B, CPM, PRKG1, MINPP1, LIPJ, LIPK, EHHADH, MOGAT1, ECHS1, STAT1, SORBS1, NFKB2, AGPAT3, CHUK, OSBPL8, PRLR, IGF1R, ACSL3, GHR and OXCT1. Our findings provide a groundwork for unraveling the key genes and causal mutations affecting milk fatty acid traits in dairy cattle. PMID:24858810

Li, Cong; Sun, Dongxiao; Zhang, Shengli; Wang, Sheng; Wu, Xiaoping; Zhang, Qin; Liu, Lin; Li, Yanhua; Qiao, Lv



Global tyrosine kinome profiling of human thyroid tumors identifies Src as a promising target for invasive cancers  

SciTech Connect

Highlights: Black-Right-Pointing-Pointer Kinome profiling is a novel technique for identifying activated kinases in human cancers. Black-Right-Pointing-Pointer Src activity is increased in invasive thyroid cancers. Black-Right-Pointing-Pointer Inhibition of Src activity decreased proliferation and invasion in vitro. Black-Right-Pointing-Pointer Further investigation of Src targeted therapies in thyroid cancer is warranted. -- Abstract: Background: Novel therapies are needed for the treatment of invasive thyroid cancers. Aberrant activation of tyrosine kinases plays an important role in thyroid oncogenesis. Because current targeted therapies are biased toward a small subset of tyrosine kinases, we conducted a study to reveal novel therapeutic targets for thyroid cancer using a bead-based, high-throughput system. Methods: Thyroid tumors and matched normal tissues were harvested from twenty-six patients in the operating room. Protein lysates were analyzed using the Luminex immunosandwich, a bead-based kinase phosphorylation assay. Data was analyzed using GenePattern 3.0 software and clustered according to histology, demographic factors, and tumor status regarding capsular invasion, size, lymphovascular invasion, and extrathyroidal extension. Survival and invasion assays were performed to determine the effect of Src inhibition in papillary thyroid cancer (PTC) cells. Results: Tyrosine kinome profiling demonstrated upregulation of nine tyrosine kinases in tumors relative to matched normal thyroid tissue: EGFR, PTK6, BTK, HCK, ABL1, TNK1, GRB2, ERK, and SRC. Supervised clustering of well-differentiated tumors by histology, gender, age, or size did not reveal significant differences in tyrosine kinase activity. However, supervised clustering by the presence of invasive disease showed increased Src activity in invasive tumors relative to non-invasive tumors (60% v. 0%, p < 0.05). In vitro, we found that Src inhibition in PTC cells decreased cell invasion and proliferation. Conclusion: Global kinome analysis enables the discovery of novel targets for thyroid cancer therapy. Further investigation of Src targeted therapy for advanced thyroid cancer is warranted.

Cho, Nancy L., E-mail: [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States); Lin, Chi-Iou [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States)] [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States); Du, Jinyan [Broad Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 (United States)] [Broad Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 (United States); Whang, Edward E. [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States)] [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States); Ito, Hiromichi [Department of Surgery, Michigan State University, Lansing, MI 48912 (United States)] [Department of Surgery, Michigan State University, Lansing, MI 48912 (United States); Moore, Francis D.; Ruan, Daniel T. [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States)] [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States)



Eliminating tobacco-related disparities among Pacific Islanders through leadership and capacity building: promising practices and lessons learned.  


Tobacco remains a major risk factor for premature death and ill health among Pacific Islanders, and tobacco-related disparities persist. Eliminating these disparities requires a comprehensive approach to transform community norms about tobacco use through policy change, as contained in the World Health Organization international Framework Convention on Tobacco Control. Three of the six U.S.-affiliated Pacific Islands-the Federated States of Micronesia, Palau, and the Marshall Islands-are Parties to the Framework; the remaining three territories-American Samoa, the Commonwealth of the Northern Mariana Islands, and Guam-are excluded from the treaty by virtue of U.S. nonratification. Capacity building and leadership development are essential in achieving policy change and health equity within Pacific Islander communities. We describe promising practices from American Samoa, the Commonwealth of the Northern Mariana Islands, the Federated States of Micronesia, Guam, and Palau and highlight some of the key lessons learned in supporting and sustaining the reduction in tobacco use among Pacific Islanders as the first step toward eliminating tobacco-related disparities in these populations. PMID:23690256

David, Annette M; Lew, Rod; Lyman, Annabel K; Otto, Caleb; Robles, Rebecca; Cruz, George J



Identifying industrial best practices for the waste minimization of low-level radioactive materials  

SciTech Connect

In US DOE, changing circumstances are affecting the management and disposal of solid, low-level radioactive waste (LLW). From 1977 to 1991, the nuclear power industry achieved major reductions in solid waste disposal, and DOE is interested in applying those practices to reduce solid waste at DOE facilities. Project focus was to identify and document commercial nuclear industry best practices for radiological control programs supporting routine operations, outages, and decontamination and decommissioning activities. The project team (DOE facility and nuclear power industry representatives) defined a Work Control Process Model, collected nuclear power industry Best Practices, and made recommendations to minimize LLW at DOE facilities.

Levin, V.



"Use of Current Best Evidence": Promises and Illusions, Limitations and Contradictions in the Triangle of Research, Policy and Practice  

ERIC Educational Resources Information Center

This paper explores the methodological and epistemological implications of the relationships between R&D, policy and practice. The proposals towards "evidence-based policy and practice" are analysed with respect to this triangle from three angles: (1) meaning; (2) production; and (3) use of evidence. A comprehensive model of the research cycle,…

Lassnigg, Lorenz



Identifying Evidence-Based Practices in Special Education through High Quality Meta-Analysis  

ERIC Educational Resources Information Center

The purpose of this study was to determine if meta-analysis can be used to enhance efforts to identify evidence-based practices (EBPs). In this study, the quality of included studies acted as the moderating variable. I used the quality indicators for experimental and quasi-experimental research developed by Gersten, Fuchs, Coyne, Greenwood, and…

Friedt, Brian



A Genome-Wide Association Study Identifies Two Novel Promising Candidate Genes Affecting Escherichia coli F4ab/F4ac Susceptibility in Swine  

PubMed Central

Enterotoxigenic Escherichia coli (ETEC) expressing F4 fimbria is the major pathogenic bacteria causing diarrhoea in neonatal and post-weaning piglets. Previous studies have revealed that the susceptibility to ETEC F4ab/F4ac is an autosomal Mendelian dominant trait and the loci controlling the F4ab/F4ac receptor are located on SSC13q41, between markers SW207 and S0283. To pinpoint these loci and further validate previous findings, we performed a genome-wide association study (GWAS) using a two generation family-based population, consisting of 301 piglets with phenotypes of susceptibility to ETEC F4ab/F4ac by the vitro adhesion test. The DNA of all piglets and their parents was genotyped using the Illumina PorcineSNP60 BeadChip, and 50,972 and 50,483 SNPs were available for F4ab and F4ac susceptibility, respectively, in the association analysis after quality control. In summary, 28 and 18 significant SNPs (p<0.05) were detected associated with F4ab and F4ac susceptibility respectively at genome-wide significance level. From these significant findings, two novel candidate genes, HEG1 and ITGB5, were firstly identified as the most promising genes underlying F4ab/F4ac susceptibility in swine according to their functions and positions. Our findings herein provide a novel evidence for unravelling genetic mechanism of diarrhoea risk in piglets.

Lu, Xin; Niu, Xiao-Yan; Ding, Xiang-Dong; Liu, Jian-Feng; Zhang, Qin



New Approaches to Improving College Access, Persistence, and Success: Three Exemplary Postsecondary Opportunity Programs. A Report from the Wisconsin Center for the Advancement of Postsecondary Education (WISCAPE) and the MHEC Promising Practices Series  

ERIC Educational Resources Information Center

This is the second in an occasional series called "Promising Practices: What Works in the Midwest." The series was launched to showcase innovative initiatives and effective ways to address common challenges and unique opportunities in higher education. Promising practices enable educators and policymakers to compare and benchmark themselves to…

Vaade, Elizabeth Stransky; Connery, J. Edward; McCready, Bo



Examining the practice of generalist expertise: a qualitative study identifying constraints and solutions  

PubMed Central

Objectives Provision of person-centred generalist care is a core component of quality primary care systems. The World Health Organisation believes that a lack of generalist primary care is contributing to inefficiency, ineffectiveness and inequity in healthcare. In UK primary care, General Practitioners (GPs) are the largest group of practising generalists. Yet GPs fulfil multiple roles and the pressures of delivering these roles along with wider contextual changes create real challenges to generalist practice. Our study aimed to explore GP perceptions of enablers and constraints for expert generalist care, in order to identify what is needed to ensure health systems are designed to support the generalist role. Design Qualitative study in General Practice. Setting UK primary care. Main outcome measures A qualitative study – interviews, surveys and focus groups with GPs and GP trainees. Data collection and analysis was informed by Normalisation Process Theory. Design and setting Qualitative study in General Practice. We conducted interviews, surveys and focus groups with GPs and GP trainees based mainly, but not exclusively, in the UK. Data collection and analysis were informed by Normalization Process Theory. Participants UK based GPs (interview and surveys); European GP trainees (focus groups). Results Our findings highlight key gaps in current training and service design which may limit development and implementation of expert generalist practice (EGP). These include the lack of a consistent and universal understanding of the distinct expertise of EGP, competing priorities inhibiting the delivery of EGP, lack of the consistent development of skills in interpretive practice and a lack of resources for monitoring EGP. Conclusions We describe four areas for change: Translating EGP, Priority setting for EGP, Trusting EGP and Identifying the impact of EGP. We outline proposals for work needed in each area to help enhance the expert generalist role.

Reeve, Joanne; Dowrick, Christopher F; Freeman, George K; Gunn, Jane; Mair, Frances; May, Carl; Mercer, Stewart; Palmer, Victoria; Howe, Amanda; Irving, Greg; Shiner, Alice; Watson, Jessica



Barcode Identifiers as a Practical Tool for Reliable Species Assignment of Medically Important Black Yeast Species  

PubMed Central

Herpotrichiellaceous black yeasts and relatives comprise severe pathogens flanked by nonpathogenic environmental siblings. Reliable identification by conventional methods is notoriously difficult. Molecular identification is hampered by the sequence variability in the internal transcribed spacer (ITS) domain caused by difficult-to-sequence homopolymeric regions and by poor taxonomic attribution of sequences deposited in GenBank. Here, we present a potential solution using short barcode identifiers (27 to 50 bp) based on ITS2 ribosomal DNA (rDNA), which allows unambiguous definition of species-specific fragments. Starting from proven sequences of ex-type and authentic strains, we were able to describe 103 identifiers. Multiple BLAST searches of these proposed barcode identifiers in GenBank revealed uniqueness for 100 taxonomic entities, whereas the three remaining identifiers each matched with two entities, but the species of these identifiers could easily be discriminated by differences in the remaining ITS regions. Using the proposed barcode identifiers, a 4.1-fold increase of 100% matches in GenBank was achieved in comparison to the classical approach using the complete ITS sequences. The proposed barcode identifiers will be made accessible for the diagnostic laboratory in a permanently updated online database, thereby providing a highly practical, reliable, and cost-effective tool for identification of clinically important black yeasts and relatives.

Heinrichs, Guido; de Hoog, G. Sybren



Issues in Educating Young Gifted Children: Promising Practices. Leadership Accessing Monograph: Education of Gifted and Talented Youth.  

ERIC Educational Resources Information Center

This monograph addresses issues and problems related to identification of and programming for gifted/talented children of preschool, kindergarten, and primary age. Barriers to early identification and programming are identified. A rationale for early identification and programming is presented, followed by administrative options including…

Karnes, Merle


Searching Usenet for Virtual Communities of Practice: Using Mixed Methods to Identify the Constructs of Wenger's Theory  

ERIC Educational Resources Information Center

Introduction: This research set out to determine whether communities of practice can be entirely Internet-based by formally applying Wenger's theoretical framework to Internet collectives. Method: A model of a virtual community of practice was developed which included the constructs Wenger identified in co-located communities of practice: mutual…

Murillo, Enrique



Practical strategies for identifying groundwater discharges into sediment and surface water with fiber optic temperature measurement.  


Identifying or ruling out groundwater discharges into sediment and surface waters is often critical for evaluating impacts and for planning remedial actions. Information about subsurface structure and groundwater can be helpful, but imperfect information, heterogeneous materials, and the likelihood of preferential pathways make it difficult to locate seeps without direct seep monitoring. We present the practical application of a method that uses fiber optic temperature measurement to provide high-resolution, sensitive, and dynamic monitoring of seepage from sediments over large areas: distributed temperature sensing to identify groundwater discharge (DTSID). First, we introduce a stochastic Monte Carlo method for designing DTSID installation based on site characteristics and the required probability of detecting particular size seeps. We then present practical methods for analysing DTSID results to prioritize locations for further investigation used at three industrial locations. Summer conditions generally presented greater difficulty in the method due to stronger environmentally-driven temperature fluctuations and thermal stratification of surface water. Tidal fluctuations were shown to be helpful in seepage detection at some locations by creating a dynamic temperature pattern that likely reflects changing seepage with varying water levels. At locations with suitable conditions for the application of DTSID, it can provide unique information regarding likely seep locations, enhancing an integrated site investigation. PMID:24841752

Selker, John; Selker, Frank; Huff, Julie; Short, Russ; Edwards, Deborah; Nicholson, Peter; Chin, Arthur



Lessons learnt from promising practices in community engagement for the elimination of new HIV infections in children by 2015 and keeping their mothers alive: summary of a desk review  

PubMed Central

Introduction Through The Global Plan Towards the Elimination of New HIV Infections Among Children by 2015 and Keeping their Mothers Alive, leaders have called for broader action to strengthen the involvement of communities. The Global Plan aspires to reduce new HIV infections among children by 90 percent, and to reduce AIDS-related maternal mortality by half. This article summarizes the results of a review commissioned by UNAIDS to help inform stakeholders on promising practices in community engagement to accelerate progress towards these ambitious goals. Methods This research involved extensive literature review and key informant interviews. Community engagement was defined to include participation, mobilization and empowerment while excluding activities that involve communities solely as service recipients. A promising practice was defined as one for which there is documented evidence of its effectiveness in achieving intended results and some indication of replicability, scale up and/or sustainability. Results Promising practices that increased the supply of preventing mother-to-child transmission (PMTCT) services included extending community cadres, strengthening linkages with community- and faith-based organizations and civic participation in programme monitoring. Practices to improve demand for PMTCT included community-led social and behaviour change communication, peer support and participative approaches to generate local solutions. Practices to create an enabling environment included community activism and government leadership for greater involvement of communities. Committed leadership at all levels, facility, community, district and national, is crucial to success. Genuine community engagement requires a rights-based, capacity-building approach and sustained financial and technical investment. Participative formative research is a first step in building community capacity and helps to ensure programme relevance. Building on existing structures, rather than working in parallel to them, improves programme efficiency, effectiveness and sustainability. Monitoring, innovation and information sharing are critical to scale up. Conclusions Ten recommendations on community engagement are offered for ending vertical transmission and enhancing the health of mothers and families: (1) expand the frontline health workforce, (2) increase engagement with community- and faith-based organizations, (3) engage communities in programme monitoring and accountability, (4) promote community-driven social and behaviour change communication including grassroots campaigns and dialogues, (5) expand peer support, (6) empower communities to address programme barriers, (7) support community activism for political commitment, (8) share tools for community engagement, (9) develop better indicators for community involvement and (10) conduct cost analyses of various community engagement strategies. As programmes expand, care should be taken to support and not to undermine work that communities are already doing, but rather to actively identify and build on such efforts.

Gulaid, Laurie Ackerman; Kiragu, Karusa



Perceptions, Promising Practices, and Pitfalls  

ERIC Educational Resources Information Center

university/school partnership. These teachers were selected from a group of 65 teachers who had participated in the online mentoring program. In this program of two time periods lasting two months each,…

Binkley, Russell; Scales, Roya; Unruh, Lori; Holt, Janice; Nichols, Janet



Promising practices in leadership development.  


The authors describe what they have learned from 10 years as designers and facilitators of the award-winning Dorothy Wylie Nursing and Health Leaders Institutes. Since 2001 they have offered 23 institutes to over 2,200 existing and emerging health leaders to promote their leadership development and learning. As well, they have supported the development and execution of close to 900 leadership application projects initiated by participants for their organizations. The authors offer knowledge and insights related to three key areas: (a) the individual (the leadership aspirant or learner), (b) the organization's role in supporting leadership development and (c) leadership program design. PMID:22008619

Simpson, Beverley; Green, Judith Skelton; Scott, Julia



Interactive Multimedia: Practice and Promise.  

ERIC Educational Resources Information Center

This book describes developments in interactive multimedia (IMM) in the early 1990s. Its aim is to provide educators, students, trainers, librarians, managers, and practitioners with an overview, not only of the directions and uses of the technology, but also of the research foundations and educational and contextual issues that need to be…

Latchem, Colin, Ed.; And Others


A Case Study with an Identified Bully: Policy and Practice Implications  

PubMed Central

Objective: Bullying is a serious public health problem that may include verbal or physical injury as well as social isolation or exclusion. As a result, research is needed to establish a database for policies and interventions designed to prevent bullying and its negative effects. This paper presents a case study that contributes to the literature by describing an intervention for bullies that has implications for practice and related policies regarding bullying. Methods: An individualized intervention for an identified bully was implemented using the Participatory Culture-Specific Intervention Model (PCSIM; Nastasi, Moore, & Varjas, 2004) with a seventh-grade middle school student. Ecological and culture-specific perspectives were used to develop and implement the intervention that included psychoeducational sessions with the student and consultation with the parent and school personnel. A mixed methods intervention design was used with the following informants: the target student, the mother of the student, a teacher and the school counselor. Qualitative data included semi-structured interviews with the parent, teacher and student, narrative classroom observations and evaluation/feedback forms filled out by the student and interventionist. Quantitative data included the following quantitative surveys (i.e., Child Self Report Post Traumatic Stress Reaction Index and the Behavior Assessment Scale for Children). Both qualitative and quantitative data were used to evaluate the acceptability, integrity and efficacy of this intervention. Results: The process of intervention design, implementation and evaluation are described through an illustrative case study. Qualitative and quantitative findings indicated a decrease in internalizing, externalizing and bullying behaviors as reported by the teacher and the mother, and a high degree of acceptability and treatment integrity as reported by multiple stakeholders. Conclusion: This case study makes important contributions by describing an intervention that is targeted to specific needs of the bully by designing culture specific interventions and working with the student’s unique environmental contexts. Contributions also are made by illustrating the use of mixed methods to document acceptability, integrity and efficacy of an intervention with documented positive effects in these areas. In addition, implications for policy and practice related to the treatment of students identified as bullies and future research needs are discussed.

Huddleston, Lillie B.; Varjas, Kris; Meyers, Joel; Cadenhead, Catherine



Identifying Practical Solutions to Meet America's Fiber Needs: Proceedings from the Food & Fiber Summit  

PubMed Central

Fiber continues to be singled out as a nutrient of public health concern. Adequate intakes of fiber are associated with reduced risk for cardiovascular disease, cancer, diabetes, certain gastrointestinal disorders and obesity. Despite ongoing efforts to promote adequate fiber through increased vegetable, fruit and whole-grain intakes, average fiber consumption has remained flat at approximately half of the recommended daily amounts. Research indicates that consumers report increasingly attempting to add fiber-containing foods, but there is confusion around fiber in whole grains. The persistent and alarmingly low intakes of fiber prompted the “Food & Fiber Summit,” which assembled nutrition researchers, educators and communicators to explore fiber’s role in public health, current fiber consumption trends and consumer awareness data with the objective of generating opportunities and solutions to help close the fiber gap. The summit outcomes highlight the need to address consumer confusion and improve the understanding of sources of fiber, to recognize the benefits of various types of fibers and to influence future dietary guidance to provide prominence and clarity around meeting daily fiber recommendations through a variety of foods and fiber types. Potential opportunities to increase fiber intake were identified, with emphasis on meal occasions and food categories that offer practical solutions for closing the fiber gap.

Mobley, Amy R.; Jones, Julie Miller; Rodriguez, Judith; Slavin, Joanne; Zelman, Kathleen M.



Identifying Practical Solutions to Meet America's Fiber Needs: Proceedings from the Food & Fiber Summit.  


Fiber continues to be singled out as a nutrient of public health concern. Adequate intakes of fiber are associated with reduced risk for cardiovascular disease, cancer, diabetes, certain gastrointestinal disorders and obesity. Despite ongoing efforts to promote adequate fiber through increased vegetable, fruit and whole-grain intakes, average fiber consumption has remained flat at approximately half of the recommended daily amounts. Research indicates that consumers report increasingly attempting to add fiber-containing foods, but there is confusion around fiber in whole grains. The persistent and alarmingly low intakes of fiber prompted the "Food & Fiber Summit," which assembled nutrition researchers, educators and communicators to explore fiber's role in public health, current fiber consumption trends and consumer awareness data with the objective of generating opportunities and solutions to help close the fiber gap. The summit outcomes highlight the need to address consumer confusion and improve the understanding of sources of fiber, to recognize the benefits of various types of fibers and to influence future dietary guidance to provide prominence and clarity around meeting daily fiber recommendations through a variety of foods and fiber types. Potential opportunities to increase fiber intake were identified, with emphasis on meal occasions and food categories that offer practical solutions for closing the fiber gap. PMID:25006857

Mobley, Amy R; Jones, Julie Miller; Rodriguez, Judith; Slavin, Joanne; Zelman, Kathleen M



Identifying Key Factors in Homeowner's Adoption of Water Quality Best Management Practices  

NASA Astrophysics Data System (ADS)

The recognition of the significance of the residential environment in contributing to non-point source (NPS) pollution and the inherently dispersed nature of NPS pollution itself that presents significant challenges to effective regulation has led to the creation and dissemination of best management practices (BMPs) that can reduce the impacts of NPS pollution (Environmental Protection Agency US, Protecting water quality from urban runoff,, 2003). However, very few studies have examined the factors that influence the adoption of BMPs by residential homeowners, despite the fact that residential environments have been identified as one of the most significant contributors to NPS pollution. Given this need, the purpose of this project was to explore how demographic and knowledge-based factors predict adoption of residential BMPs in an urbanizing watershed in Northern Illinois using statistical analyses of survey data collected as part of a watershed planning process. The findings indicate that broad knowledge of BMPs is the strongest predictor of use for a specific BMP. Knowledge of BMPs is strongly correlated with their use, which reinforces the need for educational programs, even among those assumed to be knowledgeable about BMPs.

Brehm, Joan M.; Pasko, Danielle K.; Eisenhauer, Brian W.



Identifying Perceived Barriers and Facilitators to Culturally Competent Practice for School Social Workers  

ERIC Educational Resources Information Center

This study presents descriptive findings from self-reported qualitative and quantitative data on barriers and facilitators to culturally competent school social work practice. The study highlights the need for the development of evaluative methods for the purpose of examining how elements within the practice environment affect school social work…

Teasley, Martell; Gourdine, Ruby; Canfield, James



The Use of Single Subject Research to Identify Evidence-based Practice in Special Education  

Microsoft Academic Search

Single-subject research plays an important role in the development of evidence-based practice in special education. The defining features of single-subject research are presented, the con- tributions of single-subject research for special education are reviewed, and a specific proposal is of- fered for using single-subject research to document evidence-based practice. This article allows readers to determine if a specific study is




Improving clinical practice using clinical decision support systems: a systematic review of trials to identify features critical to success  

Microsoft Academic Search

Objective To identify features of clinical decision support systems critical for improving clinical practice. Design Systematic review of randomised controlled trials. Data sources Literature searches via Medline, CINAHL, and the Cochrane Controlled Trials Register up to 2003; and searches of reference lists of included studies and relevant reviews. Study selection Studies had to evaluate the ability of decision support systems

Kensaku Kawamoto; Caitlin A Houlihan; E Andrew Balas; David F Lobach



Best Practices in Identifying Students for Gifted and Talented Education Programs  

ERIC Educational Resources Information Center

As school psychologists move from dichotomous categorizations of students as "gifted" or "nongifted" toward a more comprehensive approach to identification, their task becomes increasingly complex. In the present article, the authors outline practices at the planning, programming, and data collection stages of the identification process in hopes…

Worrell, Frank C.; Erwin, Jesse O.



The Use of Single-Subject Research to Identify Evidence-Based Practice in Special Education  

ERIC Educational Resources Information Center

Single-subject research plays an important role in the development of evidence-based practice in special education. The defining features of single-subject research are presented, the contributions of single-subject research for special education are reviewed, and a specific proposal is offered for using single-subject research to document…

Horner, Robert H.; Carr, Edward G.; Halle, James; McGee, Gail; Odom, Samuel; Wolery, Mark



Identifying and Clarifying Values and Reason Statements that Promote Effective Food Parenting Practices, Using Intensive Interviews  

ERIC Educational Resources Information Center

Objective: Generate and test parents' understanding of values and associated reason statements to encourage effective food parenting practices. Methods: This study was cross-sectional. Sixteen parents from different ethnic groups (African American, white, and Hispanic) living with their 3- to 5-year-old child were recruited. Interested parents…

Beltran, Alicia; Hingle, Melanie D.; Knesek, Jessica; O'Connor, Teresia; Baranowski, Janice; Thompson, Debbe; Baranowski, Tom



Insights into Innovative Classroom Practices with ICT: Identifying the Impetus for Change  

ERIC Educational Resources Information Center

This paper draws on the literature of transformational leadership and learning organisation with a concern to foster innovative changes in classroom practices. Based on the understanding that effective use of ICT has to be construed in the pedagogical and organisational context, this study focuses on the impact of the relevant contextual factors…

Wong, Emily M. L.; Li, Sandy S. C.; Choi, Tat-heung; Lee, Tsz-ngong



Arsenic-induced skin conditions identified in southwest dermatology practices: an epidemiologic tool?  


Populations living in the Southwest United States are more likely to be exposed to elevated drinking water arsenic levels compared to other areas of the country. Skin changes, including hyperpigmentation and generalized hyperkeratosis, are the most common signs of chronic arsenic ingestion from drinking water. The purpose of this study was to determine the feasibility of using dermatology practices in New Mexico, Arizona, and western Texas as a surveillance system for arsenical skin disorders related to drinking water. Postcard questionnaires were mailed to practicing dermatologists. The number of cases of arsenical hyperpigmentation/keratoses seen by these dermatologists during the past 10 years and the past year were estimated. Of 240 dermatologists who were mailed questionnaires, 37 reported seeing 237 patients with arsenical hyperpigmentation/keratoses in the past 10 years and 35 patients in the past year. Since approximately one-eighth of dermatologists practicing in the Southwest saw at least one patient with arsenical hyperpigmentation/keratoses during one year, it appears feasible to complete a population-based study of these conditions. PMID:15688130

Tollestrup, Kristine; Frost, Floyd J; Cristiani, Michelle; McMillan, Garnett P; Calderon, Rebecca L; Padilla, R Steven



Biomarkers identified with time-lapse imaging: discovery, validation, and practical application.  


"Time-lapse markers," which are defined by time-lapse imaging and correlated with clinical outcomes, may provide embryologists with new opportunities for improving embryo selection. This article provides an overview of noninvasive biomarkers defined by time-lapse imaging studies. In addition to comprehensively reviewing the discovery of each time-lapse marker, it focuses on the criteria necessary for their successful integration into clinical practice, including [1] statistical and biological significance, [2] validation through prospective clinical studies, and [3] development of reliable technology to measure and quantify the time-lapse marker. Because manual analysis of time-lapse images is labor intensive and limits the practical use of the image data in the clinic, automated image analysis software platforms may contribute substantially to improvements in embryo selection accuracy. Ultimately, time-lapse markers that are based on a foundation of basic research, validated through prospective clinical studies, and enabled by a reliable quantification technology may improve IVF success rates, encourage broader adoption of single-embryo transfer, and reduce the risks associated with multiple gestation pregnancies. PMID:23499001

Chen, Alice A; Tan, Lei; Suraj, Vaishali; Reijo Pera, Renee; Shen, Shehua



Identifying men at high risk of heart attacks: strategy for use in general practice  

Microsoft Academic Search

A strategy was devised for identifying men at high risk of acute myocardial infarction or sudden ischaemic death. A risk score was devised using cigarette smoking, mean blood pressure, recall of ischaemic heart disease or diabetes mellitus diagnosed by a doctor, history of parental death from \\

A G Shaper; S J Pocock; A N Phillips; M Walker



Ecological Congruence Assessment for Classroom Activities and Routines: Identifying Goals and Intervention Practices in Childcare.  

ERIC Educational Resources Information Center

This article explains how educators can use the ecological congruence assessment process for identifying functional goals for young children with disabilities. Process steps include: teacher collects information about functioning in usual classroom activities, routines, and transitions; summarizes the collected information; and shares the…

Wolery, Mark; Brashers, Margaret Sigalove; Neitzel, Jennifer C.



Practical method to identify orbital anomaly as spacecraft breakup in the geostationary region  

NASA Astrophysics Data System (ADS)

Identifying spacecraft breakup events is an essential issue for better understanding of the current orbital debris environment. This paper proposes an observation planning approach to identify an orbital anomaly, which appears as a significant discontinuity in archived orbital history, as a spacecraft breakup. The proposed approach is applicable to orbital anomalies in the geostationary region. The proposed approach selects a spacecraft that experienced an orbital anomaly, and then predicts trajectories of possible fragments of the spacecraft at an observation epoch. This paper theoretically demonstrates that observation planning for the possible fragments can be conducted. To do this, long-term behaviors of the possible fragments are evaluated. It is concluded that intersections of their trajectories will converge into several corresponding regions in the celestial sphere even if the breakup epoch is not specified and it has uncertainty of the order of several weeks.

Uetsuhara, Masahiko; Hanada, Toshiya



Pharmaceutical Care Plan Examinations to Identify Students at Risk for Poor Performance in Advanced Pharmacy Practice Experiences  

PubMed Central

Objectives To evaluate early predictors of advanced pharmacy practice experience (APPE) performance using either timed pharmaceutical care plan (TPCP) reports of 4 case histories or traditional lecture-based pharmacotherapy course examinations. Methods Statistical process control (SPC) methods were used to identify a group of third-year pharmacy students “at risk” for poor APPE performance (defined as an APPE grade point average of < 3.0). Examination scores from an integrated lecture-based pharmacotherapy sequence were used for comparison. Results TPCP scores but not lecture-based examination scores successfully identified 6 of 10 students who ultimately performed poorly in their APPEs. Conclusion Adaptation of SPC methods to assess student performance during problem-based learning (PBL) case reports is a useful technique for identifying students “at risk” for poor APPE performance.



Persistent Identifiers in the Publication and Citation of Scientific Data - Theory and Practice  

NASA Astrophysics Data System (ADS)

In the last decade data driven research has become a third pillar of scientific work alongside with theoretical reasoning and experiment. Greatly increased computing power and storage, together with web services and other electronic resources have facilitated a quantum leap in new research based on the analysis of great amounts of data. However, traditional scientific communication only slowly changes to new media other than an emulation of paper. This leaves many data inaccessible and, in the long run exposes valuable data to the risk of loss. To improve access to data and to create incentives for scientists to make their data accessible, a group of German data centres initiated the project "Publication and Citation of Scientific Data" (STD-DOI) which was funded by the German Science Foundation DFG for the periods 2003-2005 and 2006-2008. In this project the German National Library for Science and Technology (TIB Hannover), together with the German Research Centre for Geoscience (GFZ Potsdam), Alfred Wegener Institute for Polar and Marine Research (AWI) Bremerhaven, University of Bremen, the Max Planck Institute for Meteorology in Hamburg, and the DLR German Remote Sensing Data Center set up the first system to assign DOIs to data sets and for their publication. A prerequisite for data to be made available is a proper citation. This means that all fields mandatory for a bibliographic citation are included. In addition, a mechanism is needed that ensures that the location of the referenced data on the internet can be resolved at any time. In the past, this was a problematic issue because URLs are short-lived, many becoming invalid after only a few months. Data publication on the internet therefore needs a system of reliable pointers to a web publication to make these publications citeable. To achieve this persistence of identifiers for their conventional publications many scientific publishers use Digital Object Identifiers (DOI). The identifier is resolved through the handle system to the valid location (URL) where the dataset can be found. This approach meets one of the prerequisites for citeability of scientific data published online. In addition, the valid bibliographic citation can be included in the catalogues of German National Library of Science and Technology (TIB). The data publications themselves are held at discipline specific data centres, for instance ICSU World Data Centers. The data providers take on the role of publication agents and are responsible for the long-term availability of the data. The discipline specific publication agents are also responsible for the quality of the published data. Syntactic and semantic quality checks are used to secure data quality. Data may come as data supplements to scientific papers, or as time series from environmental monitoring systems, or as novel form of publication in a data journal. The latter requires a peer-review process, analogous to conventional science publications.

Klump, J.; Brase, J.; Diepenbroek, M.; Grobe, H.; Hildenbrand, B.; Hoeck, H.; Lautenschlager, M.; Sens, I.



Enhance patient safety by identifying and minimizing risk exposures affecting nurse practitioner practice.  


A study analyzing closed professional liability claims against nurse practitioners over a 5-year period was completed by CNA and Nurses Service Organization (NSO). Of 200 closed claims, the average total incurred payment per claim was $285 645. The study identifies current liability patterns and trends and provides risk-control recommendations to enhance patient safety and minimize liability exposure. Study results indicate that while the number of nurse practitioner claims have been relatively stable over the past 5 years (2007-2011), the number of claims resulting in very severe indemnity payment have increased 19% since 2009. The data also show that many claims develop from a failure involving core competencies, such as treatment and care management, and medication prescribing. Allegations related to failure to diagnose and delay in making a correct diagnosis were found most frequently. The claims demonstrate that nurse practitioners are responsible for obtaining and documenting the results of appropriate tests, consultations, and overall need for medical intervention to meet the patient's medical needs. PMID:24078206

Leigh, June; Flynn, Jennifer



The Promise and Challenge of Practice-Research Collaborations: Guiding Principles and Strategies for Initiating, Designing, and Implementing Program Evaluation Research  

ERIC Educational Resources Information Center

The authors present a set of guiding principles and strategies to facilitate the collaborative efforts of social work researchers and practitioners as they initiate, design, and implement outcome evaluations of human service interventions and programs. Beginning with an exploration of the interpersonal barriers to practice-research collaborations,…

Secret, Mary; Abell, Melissa L.; Berlin, Trey



Promising Practices: A Case Study of One Fifth Grade Class as They Grew as Writers, Prepared, and Performed on the State Essay Test  

ERIC Educational Resources Information Center

The purpose of this case study is to document the ways in which fifth-grade students in a historically, low-performing school learned to write from a teacher who did not emphasize test-taking processes. The study demonstrates how these instructional practices in a writing workshop context positively affected the student performance on a statewide…

Lewinski, Kimberly E.



Laboratory test ordering and results management systems: a qualitative study of safety risks identified by administrators in general practice  

PubMed Central

Objective To explore experiences and perceptions of frontline administrators involved in the systems-based management of laboratory test ordering and results handling in general medical practice. Design Qualitative using focus group interviews. Setting West of Scotland general medical practices in three National Health Service (NHS) territorial board areas. Participants Convenience samples of administrators (receptionists, healthcare assistants and phlebotomists). Methods Transcript data were subjected to content analysis. Results A total of 40 administrative staff were recruited. Four key themes emerged: (1) system variations and weaknesses (eg, lack of a tracking process is a known risk that needs to be addressed). (2) Doctor to administrator communication (eg, unclear information can lead to emotional impacts and additional workload). (3) Informing patients of test results (eg, levels of anxiety and uncertainty are experienced by administrators influenced by experience and test result outcome) and (4) patient follow-up and confidentiality (eg, maintaining confidentiality in a busy reception area can be challenging). The key findings were explained in terms of sociotechnical systems theory. Conclusions The study further confirms the safety-related problems associated with results handling systems and adds to our knowledge of the communication and psychosocial issues that can affect the health and well-being of staff and patients alike. However, opportunities exist for practices to identify barriers to safe care, and plan and implement system improvements to accommodate or mitigate the potential for human error in this complex area.

Bowie, Paul; Halley, Lyn; McKay, John



Exploring the Promise of Eudaimonic Well-Being Within the Practice of Health Promotion: The “How” is as Important as the “What”  

Microsoft Academic Search

A brief historical and philosophical analysis suggests that the biomedical model and prevention have been the pillars of health\\u000a promotion practices with the underlying assumption that these concepts provide answers to people’s health woes. Another observation\\u000a resulting from this analysis is that biomedical, prevention, and more recently, wellness, do not differ much from each other\\u000a paradigmatically (e.g., instrumental rationality) and,

Jay Kimiecik



The Promise of Transformative Partnerships  

ERIC Educational Resources Information Center

The promise, potential, and problems associated with school-university partnerships interested in better preparing teachers for the challenges they face teaching in today's schools rest in educators' ability to actualize transformative practices within partnership contexts. To date, most partnerships have focused on less complex forms of…

Yendol-Hoppey, Diane



Applying psychological theory to evidence-based clinical practice: identifying factors predictive of taking intra-oral radiographs.  


This study applies psychological theory to the implementation of evidence-based clinical practice. The first objective was to see if variables from psychological frameworks (developed to understand, predict and influence behaviour) could predict an evidence-based clinical behaviour. The second objective was to develop a scientific rationale to design or choose an implementation intervention. Variables from the Theory of Planned Behaviour, Social Cognitive Theory, Self-Regulation Model, Operant Conditioning, Implementation Intentions and the Precaution Adoption Process were measured, with data collection by postal survey. The primary outcome was the number of intra-oral radiographs taken per course of treatment collected from a central fee claims database. Participants were 214 Scottish General Dental Practitioners. At the theory level, the Theory of Planned Behaviour explained 13% variance in the number of radiographs taken, Social Cognitive Theory explained 7%, Operant Conditioning explained 8%, Implementation Intentions explained 11%. Self-Regulation and Stage Theory did not predict significant variance in radiographs taken. Perceived behavioural control, action planning and risk perception explained 16% of the variance in number of radiographs taken. Knowledge did not predict the number of radiographs taken. The results suggest an intervention targeting predictive psychological variables could increase the implementation of this evidence-based practice, while influencing knowledge is unlikely to do so. Measures which predicted number of radiographs taken also predicted intention to take radiographs, and intention accounted for significant variance in behaviour (adjusted R(2)=5%: F(1,166)=10.28, p<.01), suggesting intention may be a possible proxy for behavioural data when testing an intervention prior to a service-level trial. Since psychological frameworks incorporate methodologies to measure and change component variables, taking a theory-based approach enabled the creation of a methodology that can be replicated for identifying factors predictive of clinical behaviour and for the design and choice of interventions to modify practice as new evidence emerges. PMID:16843579

Bonetti, Debbie; Pitts, Nigel B; Eccles, Martin; Grimshaw, Jeremy; Johnston, Marie; Steen, Nick; Glidewell, Liz; Thomas, Ruth; Maclennan, Graeme; Clarkson, Jan E; Walker, Anne



Developing clinical practice guidelines: target audiences, identifying topics for guidelines, guideline group composition and functioning and conflicts of interest  

PubMed Central

Clinical practice guidelines are one of the foundations of efforts to improve health care. In 1999, we authored a paper about methods to develop guidelines. Since it was published, the methods of guideline development have progressed both in terms of methods and necessary procedures and the context for guideline development has changed with the emergence of guideline clearing houses and large scale guideline production organisations (such as the UK National Institute for Health and Clinical Excellence). It therefore seems timely to, in a series of three articles, update and extend our earlier paper. In this first paper we discuss: the target audience(s) for guidelines and their use of guidelines; identifying topics for guidelines; guideline group composition (including consumer involvement) and the processes by which guideline groups function and the important procedural issue of managing conflicts of interest in guideline development.



Developing Mathematically Promising Students.  

ERIC Educational Resources Information Center

This book, written on the recommendation of the Task Force on Mathematically Promising Students, investigates issues involving the development of promising mathematics students. Recommendations are made concerning topics such as the definition of promising students; the identification of such students; appropriate curriculum, instruction, and…

Sheffield, Linda Jensen, Ed.


Of birds, carbon and water: integrating multiple ecosystem service impacts to identify locations for agricultural conservation practice adoption  

EPA Science Inventory

Human use of the landscape for crop production can degrade ecosystem services. A number of agricultural conservation practices are touted as mitigating these impacts. Many of these practices are encouraged by incentive programs such as the Conservation Reserve Program administere...


Promising Electric Aircraft Drive Systems  

NASA Technical Reports Server (NTRS)

An overview of electric aircraft propulsion technology performance thresholds for key power system components is presented. A weight comparison of electric drive systems with equivalent total delivered energy is made to help identify component performance requirements, and promising research and development opportunities.

Dudley, Michael R.



The Flat Stanley Project. Promising Practices.  

ERIC Educational Resources Information Center

Students make paper "Flat Stanleys" and send them with blank journals to classes in other states or countries. Recipients treat Stanley as a guest, record the things they do with him, and return him with the completed journals to the senders. Flat Stanley has sparked teacher and student creativity and motivation in 2,500 classes in 18 countries.…

Hubert, Dale



[Promising immunonutrients in general medical practice].  


The review gives data on prospects for using agents based on probiotics and trace elements for immunomodulation. It presents information on that a Lactobacillus casei rhamnosus 35-based probiotic is able to reduce the incidence and severity of viral and bacterial infections. The potential of zinc and selenium as immunotropic agents is shown. PMID:24772516

Shevyakov, M A; Burygina, E V



Multicultural Science Education: Theory, Practice, and Promise  

ERIC Educational Resources Information Center

As a relatively new area of investigation, the study of multicultural education as it relates to science teaching and learning has spawned numerous interpretations by researchers and authors worldwide. The contributors of this international volume--among them are science teacher educators, science teachers, scientists, researchers, program…

Hines, S. Maxwell, Ed.



Aeroelastic tailoring - Theory, practice, and promise  

NASA Technical Reports Server (NTRS)

Aeroelastic tailoring technology is reviewed with reference to the historical background, the underlying theory, current trends, and specific applications. The specific application discussed include the Transonic Aircraft Technology program, an Advanced Design Composite Aircraft, the Wing/Inlet Advanced Development program, and the forward-swept wing. Finally, the future of aeroelastic tailoring and the development of an aeroelastic tailoring analysis and design tool under the Automated Strength-Aeroelastic Design program are examined.

Shirk, M. H.; Hertz, T. J.; Weisshaar, T. A.



Safe Routes to School: Practice and Promise.  

National Technical Information Service (NTIS)

This publication is designed to provide enough information about SR2S programs so those in decision-making positions will be able to determine how to allocate scarce resources and to assure positive outcomes from SR2S efforts. It delves into the history o...



Best and Promising Practices in Developmental Disabilities.  

ERIC Educational Resources Information Center

Twenty-six papers on the education of students with developmental disabilities are divided into 7 sections on: (1) definition and placement; (2) assessment and curriculum; (3) instructional strategies; (4) individual needs; (5) systematic and data-based instruction and management; (6) family involvement and community attitudes; and (7) appropriate…

Hilton, Alan, Ed.; Ringlaben, Ravic, Ed.


Restructuring Schools: Promising Practices and Policies.  

ERIC Educational Resources Information Center

Chapters in this book focus on a wide array of educational issues that command attention at the end of the 20th century. Various aspects of contemporary schooling are explored, and models of school organization and functioning are proposed in the following chapters: (1) "Achievement-Oriented School Design" (James S. Coleman); (2) "Lost in…

Hallinan, Maureen T., Ed.


Ability to Identify, Explain and Solve Problems in Everyday Tasks: Preliminary Validation of a Direct Video Measure of Practical Intelligence  

ERIC Educational Resources Information Center

Recent developments in the definitional literature on mental retardation emphasize the need to ground the concept of adaptive behavior in an expanded model of intelligence, which includes practical and social intelligence. Development of a direct measure of practical intelligence might increase the likelihood that an assessment of this domain…

Yalon-Chamovitz, Shira; Greenspan, Stephen



Identifying Instructional Targets for Early Childhood via Authentic Assessment: Alignment of Professional Standards and Practice-Based Evidence  

ERIC Educational Resources Information Center

Now at middle age, the field of Early Childhood Intervention (ECI) and its professionals have demonstrated a unique capacity to develop their own practice-based evidence (PBE) and professional standards to forge solutions to challenging professional practice dilemmas. This innovative capacity is no more evident than in designing and implementing…

Bagnato, Stephen J.; McLean, Mary; Macy, Marisa; Neisworth, John T.



Do Workshops in Evidence-Based Practice Equip Participants to Identify and Answer Questions Requiring Consideration of Clinical Research? A Diagnostic Skill Assessment  

ERIC Educational Resources Information Center

Evidence-based practice (EBP) requires practitioners to identify and formulate questions in response to patient encounters, and to seek, select, and appraise applicable clinical research. A standardized workshop format serves as the model for training of medical educators in these skills. We developed an evaluation exercise to assess the ability…

Wyer, Peter C,; Naqvi, Zoon; Dayan, Peter S.; Celentano, James J.; Eskin, Barnet; Graham, Mark J.



Off-label prescriptions: how to identify them, frame them, announce them and monitor them in practice?  


Following the Mediator crisis and the passage of the Health and Safety Law of December 2011, off-label prescriptions are a real concern shared by all those involved in healthcare system. Off-label, in the strictest sense of the term, is defined as all prescriptions that do not correspond to the summary of product characteristics (SPC), particularly those that fail to comply with the indications and dosage regimens defined by the marketing authorization (MA) for clear safety reasons. There are various rasons for off-label prescriptions, both conscious and unconscious. They are intended to respond to unmet medical needs, the needs of poorly studied populations or not studied at all in trials, but in relation to whom it is reasonable to extrapolate that MA would be given (common-sense prescriptions) and, additionally, to urgent public health needs (such as baclofen, pregnant women, and HIV drugs). All these prescriptions would deserve to be studied for a potential MA. However, there are off-label prescriptions that need to be restricted or even penalized in the case of compassionate prescriptions or unjustified prescriptions or prescriptions not based on any scientific grounds. Off-label prescriptions are not easy to track down because if the prescriber has to write "off-label" on his prescription, then clearly, in practice, he will only do so in exceptional cases. Neither the pharmacists who dispense the drug nor the Social Security that reimburses it, have access to the diagnosis (or targeted indication). Thus, in order to identify the off-label prescription, we must be able to cross reference the available databases (such as pharmacovigilance database, medicalized information system program [programme de médicalisation des systèmes d'information, PMSI], hospital drug formularies, general sample of beneficiaries [échantillon généraliste de bénéficiaires, EGB] or national inter-regional Health Insurance Information System [système national d'informations inter-régions d'Assurance maladie, SNIIRAM], sales data, and data from market surveys). The shared computerized patient file may resolve this problem. The temporary use recommendation (TUR) proposed by the Drug Safety Law will only partially deal with this problem for recently marketed molecules. This temporary and exceptional mechanism will authorize a recognized off-label prescription, which may be reimbursed and monitored for 3 years. These TURs will only concern a small portion of "off-label" drugs having yet a positive risk/benefit ratio (conditional MA) but this is far from matching with majority of off-label prescriptions. As such, and in order to improve the use of drugs, it is important to propose a control system for all "off-label" prescriptions with a dedicated committee: the "off-label" committee which would determine the frame of the "off-label" prescriptions. PMID:23981260

Le Jeunne, Claire; Billon, Nathalie; Dandon, Anne; Berdaï, Driss; Adgibi, Yolande; Bergmann, Jean-François; Bordet, Régis; Carpentier, Anne; Cohn, Emmanuelle; Courcier, Soizic; Girault, Danièle; Goni, Sylvia; Jolliet, Pascale; Liard, François; Prot-Labarthe, Sonia; Simon, Tabassome; Vernotte, Christine; Westerloppe, Jérémie



Using Conversion and Design Social R & D Principles to Identify Some Practice Implications for the Training of Trainers.  

ERIC Educational Resources Information Center

This literature review examines 12 current works dealing with converting basic research on adult learning, adult development, adult education, instructional methods, and learning theory to practical application in the training of trainers. Focus of the review is on translating principles from scientific language to language more suitable to…

Lapides, Jerry


Alzheimer's Disease and Other Dementias: An Organizational Approach to Identifying and Addressing Practices and Learning Needs of Family Physicians  

ERIC Educational Resources Information Center

Caring for patients with dementia is complex and demanding. Since family physicians (FPs) provide much of this care, we examined their practices, learning needs, and barriers to care concerning Alzheimer's disease and other dementias. We surveyed 392 (approximately 50%) Nova Scotia FPs and conducted focus groups and interviews with: FPs; staff of…

Allen, Michael; Ferrier, Suzanne; Sargeant, Joan; Loney, Elaine; Bethune, Graeme; Murphy, Gerard



Promises, Trust, and Contracts  

Microsoft Academic Search

A transaction involving a buyer and a competitive seller is studied under the hypothesis that individuals may have a certain tendency to keep promises. The parties can choose a complete contract where costly arrangements are made so that it is verifiable whether the seller has delivered a certain quality. Alternatively, they can choose an incomplete contract where the quality agreed

Yongmin Chen



The sensitivity and specificity of four questions (HARK) to identify intimate partner violence: a diagnostic accuracy study in general practice  

Microsoft Academic Search

BACKGROUND: Intimate partner violence (IPV) including physical, sexual and emotional violence, causes short and long term ill-health. Brief questions that reliably identify women experiencing IPV who present in clinical settings are a pre-requisite for an appropriate response from health services to this substantial public health problem. We estimated the sensitivity and specificity of four questions (HARK) developed from the Abuse

Hardip Sohal; Sandra Eldridge; Gene Feder



The Promise of Power  

ERIC Educational Resources Information Center

Discusses nursing in 1978 and its projected development by the year 2003. Topics covered include establishing a resource and power base, resolution of the health care crisis, expanded nursing practice, technological influences, and major challenges posed by the future. (TA)

Kalisch, Beatrice J.



Changing policy and practice in the child welfare system through collaborative efforts to identify and respond effectively to family violence.  


The Greenbook provides a roadmap for child welfare agencies to collaborate and provide effective responses to families who are experiencing co-occurring child maltreatment and domestic violence. A multisite developmental evaluation was conducted of six demonstration sites that received federal funding to implement Greenbook recommendations for child welfare agencies. Surveys of child welfare caseworkers show significant changes in several areas of agency policy and practice, including regular domestic violence training, written guidelines for reporting domestic violence, and working closely and sharing resources with local domestic violence service providers. Case file reviews show significant increases in the level of active screening for domestic violence, although this increase peaks at the midpoint of the initiative. These findings, coupled with on-site interview data, point to the importance of coordinating system change activities in child welfare agencies with a number of other collaborative activities. PMID:18349347

Banks, Duren; Landsverk, John; Wang, Kathleen



Use of technology assessment databases to identify the issues associated with adoption of structural health monitoring practices.  

SciTech Connect

The goal is to create a systematic method and structure to compile, organize, and summarize SHM related data to identify the level of maturity and rate of evolution and have a quick and ongoing evaluation of the current state of SHM among research institutions and industry. Hundreds of technical publication and conference proceedings were read and analyzed to compile the database. Microsoft Excel was used to create a useable interface that could be filtered to compare any of the entered data fields.

Roach, Dennis Patrick; Smith, Bryce; Neidigk, Stephen



Applying psychological theories to evidence-based clinical practice: identifying factors predictive of lumbar spine x-ray for low back pain in UK primary care practice  

PubMed Central

Background Psychological models predict behaviour in a wide range of settings. The aim of this study was to explore the usefulness of a range of psychological models to predict the health professional behaviour 'referral for lumbar spine x-ray in patients presenting with low back pain' by UK primary care physicians. Methods Psychological measures were collected by postal questionnaire survey from a random sample of primary care physicians in Scotland and north England. The outcome measures were clinical behaviour (referral rates for lumbar spine x-rays), behavioural simulation (lumbar spine x-ray referral decisions based upon scenarios), and behavioural intention (general intention to refer for lumbar spine x-rays in patients with low back pain). Explanatory variables were the constructs within the Theory of Planned Behaviour (TPB), Social Cognitive Theory (SCT), Common Sense Self-Regulation Model (CS-SRM), Operant Learning Theory (OLT), Implementation Intention (II), Weinstein's Stage Model termed the Precaution Adoption Process (PAP), and knowledge. For each of the outcome measures, a generalised linear model was used to examine the predictive value of each theory individually. Linear regression was used for the intention and simulation outcomes, and negative binomial regression was used for the behaviour outcome. Following this 'theory level' analysis, a 'cross-theoretical construct' analysis was conducted to investigate the combined predictive value of all individual constructs across theories. Results Constructs from TPB, SCT, CS-SRM, and OLT predicted behaviour; however, the theoretical models did not fit the data well. When predicting behavioural simulation, the proportion of variance explained by individual theories was TPB 11.6%, SCT 12.1%, OLT 8.1%, and II 1.5% of the variance, and in the cross-theory analysis constructs from TPB, CS-SRM and II explained 16.5% of the variance in simulated behaviours. When predicting intention, the proportion of variance explained by individual theories was TPB 25.0%, SCT 21.5%, CS-SRM 11.3%, OLT 26.3%, PAP 2.6%, and knowledge 2.3%, and in the cross-theory analysis constructs from TPB, SCT, CS-SRM, and OLT explained 33.5% variance in intention. Together these results suggest that physicians' beliefs about consequences and beliefs about capabilities are likely determinants of lumbar spine x-ray referrals. Conclusions The study provides evidence that taking a theory-based approach enables the creation of a replicable methodology for identifying factors that predict clinical behaviour. However, a number of conceptual and methodological challenges remain.



Altered standards of care during an influenza pandemic: identifying ethical, legal, and practical principles to guide decision making.  


Although widespread support favors prospective planning for altered standards of care during mass casualty events, the literature includes few, if any, accounts of groups that have formally addressed the overarching policy considerations at the state level. We describe the planning process undertaken by public health officials in the Commonwealth of Massachusetts, along with community and academic partners, to explore the issues surrounding altered standards of care in the event of pandemic influenza. Throughout 2006, the Massachusetts Department of Public Health and the Harvard School of Public Health Center for Public Health Preparedness jointly convened a working group comprising ethicists, lawyers, clinicians, and local and state public health officials to consider issues such as allocation of antiviral medications, prioritization of critical care, and state seizure of private assets. Community stakeholders were also engaged in the process through facilitated discussion of case scenarios focused on these and other issues. The objective of this initiative was to establish a framework and some fundamental principles that would subsequently guide the process of establishing specific altered standards of care protocols. The group collectively identified 4 goals and 7 principles to guide the equitable allocation of limited resources and establishment of altered standards of care protocols. Reviewing and analyzing this process to date may serve as a resource for other states. PMID:19755912

Levin, Donna; Cadigan, Rebecca Orfaly; Biddinger, Paul D; Condon, Suzanne; Koh, Howard K



American Promise: POV  

NSDL National Science Digital Library

Dramatic, poignant, and provocative, PBSâÂÂs Point of View documentaries provide access to often overlooked facets of American society. African-American filmmakers and parents Joe Brewster and Michèle Stephenson chronicle twelve years of educational ups and downs of their son, Idris, and his classmate Seun in American Promise. The documentary follows the two boysâ journey through ManhattanâÂÂs prestigious Dalton School as recruited students of color, shedding light on the black male achievement gap in the context of early education. Through their experiences, the viewer is offered intimate access to modern civil rights, gender and racial gaps, and generational conflict in the black community. The website offers a full length trailer, background, character descriptions, and a photo slideshow, as well as online streaming from February 4th â March 5th, 2014.



Performance Scores in General Practice: A Comparison between the Clinical versus Medication-Based Approach to Identify Target Populations  

PubMed Central

Context From one country to another, the pay-for-performance mechanisms differ on one significant point: the identification of target populations, that is, populations which serve as a basis for calculating the indicators. The aim of this study was to compare clinical versus medication-based identification of populations of patients with diabetes and hypertension over the age of 50 (for men) or 60 (for women), and any consequences this may have on the calculation of P4P indicators. Methods A comparative, retrospective, observational study was carried out with clinical and prescription data from a panel of general practitioners (GPs), the Observatory of General Medicine (OMG) for the year 2007. Two indicators regarding the prescription for statins and aspirin in these populations were calculated. Results We analyzed data from 21.690 patients collected by 61 GPs via electronic medical files. Following the clinical-based approach, 2.278 patients were diabetic, 8,271 had hypertension and 1.539 had both against respectively 1.730, 8.511 and 1.304 following the medication-based approach (% agreement?=?96%, kappa?=?0.69). The main reasons for these differences were: forgetting to code the morbidities in the clinical approach, not taking into account the population of patients who were given life style and diet rules only or taking into account patients for whom morbidities other than hypertension could justify the use of antihypertensive drugs in the medication-based approach. The mean (confidence interval) per doctor was 33.7% (31.5–35.9) for statin indicator and 38.4% (35.4–41.4) for aspirin indicator when the target populations were identified on the basis of clinical criteria whereas they were 37.9% (36.3–39.4) and 43.8% (41.4–46.3) on the basis of treatment criteria. Conclusion The two approaches yield very “similar” scores but these scores cover different realities and offer food for thought on the possible usage of these indicators in the framework of P4P programmes.

Saint-Lary, Olivier; Boisnault, Philippe; Naiditch, Michel; Szidon, Philippe; Duhot, Didier; Bourgueil, Yann; Pelletier-Fleury, Nathalie



Applying psychological theories to evidence-based clinical practice: identifying factors predictive of placing preventive fissure sealants  

PubMed Central

Background Psychological models are used to understand and predict behaviour in a wide range of settings, but have not been consistently applied to health professional behaviours, and the contribution of differing theories is not clear. This study explored the usefulness of a range of models to predict an evidence-based behaviour -- the placing of fissure sealants. Methods Measures were collected by postal questionnaire from a random sample of general dental practitioners (GDPs) in Scotland. Outcomes were behavioural simulation (scenario decision-making), and behavioural intention. Predictor variables were from the Theory of Planned Behaviour (TPB), Social Cognitive Theory (SCT), Common Sense Self-regulation Model (CS-SRM), Operant Learning Theory (OLT), Implementation Intention (II), Stage Model, and knowledge (a non-theoretical construct). Multiple regression analysis was used to examine the predictive value of each theoretical model individually. Significant constructs from all theories were then entered into a 'cross theory' stepwise regression analysis to investigate their combined predictive value Results Behavioural simulation - theory level variance explained was: TPB 31%; SCT 29%; II 7%; OLT 30%. Neither CS-SRM nor stage explained significant variance. In the cross theory analysis, habit (OLT), timeline acute (CS-SRM), and outcome expectancy (SCT) entered the equation, together explaining 38% of the variance. Behavioural intention - theory level variance explained was: TPB 30%; SCT 24%; OLT 58%, CS-SRM 27%. GDPs in the action stage had significantly higher intention to place fissure sealants. In the cross theory analysis, habit (OLT) and attitude (TPB) entered the equation, together explaining 68% of the variance in intention. Summary The study provides evidence that psychological models can be useful in understanding and predicting clinical behaviour. Taking a theory-based approach enables the creation of a replicable methodology for identifying factors that may predict clinical behaviour and so provide possible targets for knowledge translation interventions. Results suggest that more evidence-based behaviour may be achieved by influencing beliefs about the positive outcomes of placing fissure sealants and building a habit of placing them as part of patient management. However a number of conceptual and methodological challenges remain.



Is Divorce Promise-Breaking?  

Microsoft Academic Search

Wedding vows seem to be promises. So they go: “I promise to love, honour, and cherish ....” But this poses a problem. Divorce\\u000a is not widely seen as a serious moral wrong, but breaking a promise is. I first consider, and defend against preliminary objections,\\u000a a ‘hard-line’ response: divorce is indeed prima facie impermissible promise-breaking. I next consider the ‘hardship’

Elizabeth Brake



Consistent practices in artifact-mediated collaboration  

Microsoft Academic Search

The design of collaborative representations faces a challenge in integrating theoretical communication models with the context-sensitive\\u000a and creative practices of human interaction. This paper presents results from a study that identified multiple, invariant\\u000a communicative practices in how dyads appropriated flexible, paper-based media in discussions of wicked problems. These invariants,\\u000a identified across media, participants and topics are a promising first step

Nathan Dwyer; Daniel D. Suthers



Delivering reproductive health promises.  


This article briefly covers some issues involved in implementing the reproductive health agenda of the Fourth World Conference on Women, held in Beijing in 1995. A more detailed discussion is presented by the author in a Family Health International Working Paper (No. WP95-01). The reproductive health goals of the Beijing's women's conference were a ratification of the Plan of Action from the 1994 International Conference on Population and Development, Cairo. Women's empowerment is viewed as possible with a comprehensive, client-centered view of reproductive health services integrated with family planning. There remain many policy and service delivery challenges to integrated programs. The two main objectives of integrated services are to better meet client's needs and to improve efficiency and effectiveness of these services. There was some conference agreement on 16 broad groups and 76 specific services, which would be included in integrated programs. A service structure alone did not assure integrated services. The presence of established vertical programs and weak administrative capacity were obstacles, which had a more marked impact on integrated programs. Service delivery was viewed as enhanced by effective donor collaboration. A unified set of priorities between different donors must be agreed upon. Donors must also reach agreement on resource sharing, assumptions of joint responsibility for success and failure, and balancing of local priorities with agency priorities. The National Policy Development process must include a range of constituent groups, such as women's groups, policy makers, grassroots organizers, service providers, and client representatives. Service gaps could be identified by operations research efforts. A greater health impact could be achieved by programs with limited scope but clearly identified priorities than overextended comprehensive programs. Logistics and services delivery systems could adjust better when service components were phased in. Vertical government ministry organization, even with consistent national policy, was an obstacle to integration. Integration is costly, and funding needs must be secured. Implementation of integrated programs could be enhanced by use of the lessons learned already. PMID:12346900

Hardee, K



Therapeutic promise and principles  

PubMed Central

For a number of disease entities, oxidative stress becomes a significant factor in the etiology and progression of cell dysfunction and injury. Therapeutic strategies that can identify novel signal transduction pathways to ameliorate the toxic effects of oxidative stress may lead to new avenues of treatment for a spectrum of disorders that include diabetes, Alzheimer's disease, Parkinson's disease and immune system dysfunction. In this respect, metabotropic glutamate receptors (mGluRs) may offer exciting prospects for several disorders since these receptors can limit or prevent apoptotic cell injury as well as impact upon cellular development and function. Yet the role of mGluRs is complex in nature and may require specific mGluR modulation for a particular disease entity to maximize clinical efficacy and limit potential disability. Here we discuss the potential clinical translation of mGluRs and highlight the role of novel signal transduction pathways in the metabotropic glutamate system that may be vital for the clinical utility of mGluRs.

Chong, Zhao Zhong; Shang, Yan Chen; Hou, Jinling



Identifying Outstanding Talent in American Indian and Alaska Native Students.  

ERIC Educational Resources Information Center

This report reviews and synthesizes the most promising practices used to identify exceptionally talented students from the Native American population. Preliminary information includes an Indian Student Bill of Rights, discussion of the problem of talent identification, and discussion of special issues including diversity within the Native American…

Callahan, Carolyn M.; McIntire, Jay A.


Promising Investment Opportunities in South Central Alaska.  

National Technical Information Service (NTIS)

The report summarizes findings and recommendations which were developed during the 3-week field survey of South Central Alaska by a two-man team in September of 1964. The purpose was to identify promising investment opportunities in this area, establish t...



Exemplary & Promising Gender Equity Programs, 2000.  

ERIC Educational Resources Information Center

This report identifies promising and exemplary programs that promote gender equity in and through education during the 1996-99 Gender Equity Expert Panel review cycle. These programs need to meet four criteria: evidence of success/effectiveness in promoting gender equity, quality of program, educational significance, and usefulness to others or…

Department of Education, Washington, DC.


Identifying strategies to maximise recruitment and retention of practices and patients in a multicentre randomised controlled trial of an intervention to optimise secondary prevention for coronary heart disease in primary care. |

Identifying strategies to maximise recruitment and retention of practices and patients in a multicentre randomised controlled trial of an intervention to optimise secondary prevention for coronary heart disease in primary care.


A cross-sectional study identifying the pattern of factors related to psychological intimate partner violence exposure in Slovenian family practice attendees: what hurt them the most  

PubMed Central

Background Intimate partner violence (IPV) is yet to be fully acknowledged as a public health problem in Slovenia. This study aimed to explore the health and other patient characteristics associated with psychological IPV exposure and gender-related specificity in family clinic attendees. Methods In a multi-centre cross-sectional study, 960 family practice attendees aged 18 years and above were recruited. In 689 interviews with currently- or previously-partnered patients, the short form of A Domestic Violence Exposure Questionnaire and additional questions about behavioural patterns of exposure to psychological abuse in the past year were given. General practitioners (GPs) reviewed the medical charts of 470 patients who met the IPV exposure criteria. The Domestic Violence Exposure Medical Chart Check List was used, collecting data on the patients’ lives and physical, sexual and reproductive, and psychological health status, as well as sick leave, hospitalisation, visits to family practices and referrals to other clinical specialists in the past year. In multivariate logistic regression modelling the factors associated with past year psychological IPV exposure were identified, with P?



A Bold and Promising Model with a Few Loose Ends  

ERIC Educational Resources Information Center

Without a doubt the authors' proposal of viewing gifted education in systemic terms is a promising one. In fact, it is most refreshing to read something eclectic like this with an aim to synthesize a field of research and practice which for too long has lacked consensus in both practice and theory. The author agrees with them that a mechanistic…

Persson, Roland S.



Investigating the Promise of Learner Corpora: Methodological Issues  

ERIC Educational Resources Information Center

Researchers working with learner corpora promise quantitative results that would be of greater practical value in areas such as CALL than those from small-scale and qualitative studies. However, learner corpus research has not yet had an impact on practices in teaching and assessment. Significant methodological issues need to be examined if…

Pendar, Nick; Chapelle, Carol A.



Nanotechnology: Its Promise and Challenges  

SciTech Connect

Vicki Colvin of Rice University talks about how nanotechnology-enabled systems, with dimensions on the scale of a billionth of a meter, offer great promise for solving difficult social problems and creating enormous possibilities.

Vicki Colvin



Web Services: Promises and Compromises  

Microsoft Academic Search

Much of web services' initial promise will be realized via integration within the enterprise, either with legacy applications or new business processes that span organizational silos. Enterprises need organizational structures that support this new paradigm.

Joanne Martin; Ali Arsanjani; Peri Tarr; Brent Hailpern



Nanotechnology: Its Promise and Challenges  


Vicki Colvin of Rice University talks about how nanotechnology-enabled systems, with dimensions on the scale of a billionth of a meter, offer great promise for solving difficult social problems and creating enormous possibilities.


Current social work perspectives on clinical practice  

Microsoft Academic Search

Several forms of progress in the development of clinical practice theory and method are identified. There is a renewed positive valuation of psychodynamic approaches, a general acceptance of a systems framework, and a greater operationalization of procedures. The current controversy between the social work scientists and artists concerning research strategies is discussed. Three promising new perspectives—of morality, spirituality, and hermeneutics-are

Max Siporin



AMLCD cockpit: promise and payoffs  

NASA Astrophysics Data System (ADS)

The active matrix liquid crystal display (AMLCD) has become the preferred flight instrument technology in avionics multifunction display applications. Current bubble canopy fighter cockpit applications involve sizes up to 7.8 X 7.8 in. active display. Dual use avionics versions of AMLCD technology are now as large as 6.7 X 6.7 in. active display area in the ARINC D sized color multifunction display (MFD). This is the standard instrument in all new Boeing transport aircraft and is being retrofitted into the C-17A. A special design of the ARINC D instrument is used in the Space Shuttle cockpit upgrade. Larger sizes of AMLCD were desired when decisions were made in the early 1990s for the F-22. Commercial AMLCD technology has now produced monitors at 1280 X 1024 resolution (1.3 megapixels) in sizes of 16 to 21 in. diagonal. Each of these larger AMLCDs has more information carrying capacity than the entire F-22A cockpit instrument panel shipset, comprising six separate smaller AMLCDs (1.2 megapixels total). The larger AMLCDs are being integrated into airborne mission crewstations for use in dim ambient lighting conditions. It is now time to identify and address the technology challenges of upgrading these larger AMLCDs for sunlight readable application and of developing concepts for their integration into advanced bubble canopy fighter cockpits. The overall goals are to significantly increase the informational carrying capacity to bring both sensor and information fusion into the cockpit and, thereby, to enable a significant increase in warfighter situational awareness and effectiveness. A research cockpit was built using specialized versions of the IBM 16.1 in and two smaller 10 in. AMLCDs to examine human factors and display design issues associated with these next-generation AMLCD cockpit displays. This cockpit was later upgraded to allow greater reconfigurability and flexibility in the display hardware used to conduct part- task mission simulations. The objective optical characterization of the AMLCDs used in this simulator and the cockpit design are described. Display formats under consideration for test in this cockpit are described together with some of the basic human factors engineering issues involved. Studies conducted in this cockpit will be part of an ongoing joint effort of the hardware-focused aerospace displays team and the pilot-focused human factors team in the Air Force Research Laboratory's Crew System Interface Division. The objective of these studies is to ascertain the payoffs of the large AMLCD promise in combat cockpits.

Snow, Michael P.; Jackson, Timothy W.; Meyer, Frederick M.; Reising, John M.; Hopper, Darrel G.



Identifying characteristics associated with performing recommended practices in maternal and newborn care among health facilities in Rwanda: a cross-sectional study  

PubMed Central

Background Although rates of maternal and neonatal mortality have decreased in many countries over the last two decades, they remain unacceptably high, particularly in sub-Saharan Africa. Nevertheless, we know little about the quality of facility-based maternal and newborn care in low-income countries and little about the association between quality of care and health worker training, supervision, and incentives in these settings. We therefore sought to examine the quality of facility-based maternal and newborn health care by describing the implementation of recommended practices for maternal and newborn care among health care facilities. We also aimed to determine whether increased training, supervision, and incentives for health workers were associated with implementing these recommended practices. We chose to study these aims in the Republic of Rwanda, where rates of maternal and newborn mortality are high and where substantial attention is currently focused on strengthening health workforce capacity and quality. Methods We used data from the 2007 Rwanda Service Provision Assessment. Using observations from 455 facilities and interviews from 1357 providers, we generated descriptive statistics to describe the use of recommended practices and frequencies of provider training, supervision, and incentives in the areas of antenatal, delivery, and newborn care. We then constructed multivariable regression models to examine the associations between using recommended practices and health provider training, supervision, and incentives. Results Use of recommended practices varied widely, and very few facilities performed all recommended practices. Furthermore, in most areas of care, less than 25% of providers reported having had any pre-service or in-service training in the last 3?years. Contrary to our hypotheses, we found no evidence that training, supervision, or incentives were consistently associated with using recommended practices. Conclusion Our findings highlight the need to improve facility-based maternal and newborn care in Rwanda and suggest that current approaches to workforce training, supervision, and incentives may not be adequate for improving these critical practices.



Promising Characteristics of Nanocomposite Dielectrics  

Microsoft Academic Search

Polymer nanocomposites possess promising high performances as engineering materials, if they are prepared and fabricated properly. It was also clarified that they could provide favorable performances as dielectrics and electrical insulation. Comprehensive reviews were given in literatures by the author firstly in 2004 and secondly in 2005. This review is based on the second paper and covers recent significant findings.

Toshikatsu Tanaka



Adaptive management: Promises and pitfalls  

Microsoft Academic Search

Proponents of the scientific adaptive management approach argue that it increases knowledge acquisition rates, enhances information flow among policy actors, and provides opportunities for creating shared understandings. However, evidence from efforts to implement the approach in New Brunswick, British Columbia, Canada, and the Columbia River Basin indicates that these promises have not been met. The data show that scientific adaptive

Rebecca J. McLain; Robert G. Lee



Teacher in the Promised Land.  

ERIC Educational Resources Information Center

The promised land is our own bodies, our own senses, our own minds and imaginations. Those who accept this inheritance are qualified to be teachers, for in teaching we either replenish or frustrate a wondrous expectation. Ultimately, teaching is aimed at one thing--celebration. (Author/IRT)

Starratt, Robert J.



Realizing the promise of cancer predisposition genes.  


Genes in which germline mutations confer highly or moderately increased risks of cancer are called cancer predisposition genes. More than 100 of these genes have been identified, providing important scientific insights in many areas, particularly the mechanisms of cancer causation. Moreover, clinical utilization of cancer predisposition genes has had a substantial impact on diagnosis, optimized management and prevention of cancer. The recent transformative advances in DNA sequencing hold the promise of many more cancer predisposition gene discoveries, and greater and broader clinical applications. However, there is also considerable potential for incorrect inferences and inappropriate clinical applications. Realizing the promise of cancer predisposition genes for science and medicine will thus require careful navigation. PMID:24429628

Rahman, Nazneen



Identifying Key Elements of Community-Based ESD: ESD-J's Projects to Collect ESD in Practice in Japan and Asia  

ERIC Educational Resources Information Center

Since its establishment in 2003, the Japan Council on the UN Decade of Education for Sustainable Development (ESD-J) has paid close attention to informal learning processes in community-based efforts to promote local sustainable development. ESD-J carried out two projects to collect information on and visualise community-based ESD practice: the…

Noguchi, Fumiko



Feasibility evaluation of a stepped procedure to identify community-dwelling frail older people in general practice. A mixed methods study.  


Abstract Background: Implementation of frailty identification methods in general practice has hardly been established. To achieve successful implementation, general practitioners (GPs) should be provided with an identification method that suits their needs. EASYcare-TOS is a new frailty identification method that uses a stepped approach and is specifically developed for use in general practice. The first step consists of the GP's frailty judgment based on his prior information on the patient. If the judgment is 'uncertain' or 'frail,' additional data are collected by a primary care nurse (PCN). The frailty decision is based on clinical reasoning by the GP, without applying predefined cut-offs in a numerical score. Objective: To evaluate the acceptability of EASYcare-TOS in daily general practice. Methods A mixed-methods study was conducted. Questionnaires were sent to all professionals (n = 25) who participated in the EASYcare-TOS validation study. Subsequently, semi-structured interviews with primary care professionals (n = 12) and patients (n = 9) were conducted. Results: Time investment was generally perceived as acceptable. Twenty-two professionals (88%) found a two-step model (very) useful in the identification instrument. Seventeen professionals (68%) valued making the final frailty decision by their own clinical reasoning. Patients appreciated the broad assessment and the advice given based on the assessment. According to 24 (96%) professionals, EASYcare-TOS improved the quality of patient care. GPs stated that implementation will ask for reconsidering allocation of tasks in general practices and adequate reimbursement. Conclusion: EASYcare-TOS is a new identification method that fits the needs of primary care professionals to a large extent and is acceptable in daily practice. PMID:24224607

Keiren, Suzanne M G; Kempen, Janneke A L van; Schers, Henk J; Olde Rikkert, Marcel G M; Perry, Marieke; Melis, René J F



Kaleidoscope 2; A Descriptive Collection of Promising Educational Practices.  

ERIC Educational Resources Information Center

This issue of Kaleidoscope, which focuses on projects involving innovative educational change funded under ESEA Title III, describes 60 programs in both elementary and secondary schools in Massachusetts. The projects cover a wide range of educational interests including: curriculum development, environmental education, individualized instruction,…

MacAdam, Phyllis A.; Fuller, Elisabeth


Special Education Inclusion. Center for School Success Promising Practices Series  

ERIC Educational Resources Information Center

This publication focuses on special education inclusion. Inclusion is a term that expresses commitment to providing specially designed instruction and support for students with special needs in the context of a general education classroom. All students in the school are full members of the community, participating equitably in the opportunities…

Imbimbo, Josephine; Knopf, Naomi



Focus on Student Retention: Promising Practices in Community Colleges  

ERIC Educational Resources Information Center

With increased interest in learning college initiatives, growing awareness of the need to promote higher levels of student success, and continuing emphasis on state accountability measures, many community colleges are seeing the need for a comprehensive evaluation of their retention and student success initiatives. Given continuing resource…

McClenney, Kay M.; Waiwaiole, Evelyn N.



Managing Educator Talent: Promising Practices and Lessons from Midwestern States  

ERIC Educational Resources Information Center

This policy analysis explains the need for a system approach to educator talent management. The report analyzes how state policies in the Midwest support the development of effective teachers and leaders throughout their career. The report focuses on state policies in teacher preparation including certification and licensure, recruitment and…

Bhatt, Monica P.; Behrstock, Ellen



Improving Child Care in Rural Areas: Promising Practices and Strategies.  

ERIC Educational Resources Information Center

The use of the Child Care Development Block Grant (CCDBG) in combination with other funding has been an important factor in the development of initiatives to expand and improve child care services in rural areas. Based on their personal knowledge, a technical advisory group and experts recommended states with innovative, unique, and successful…

Macro International, Inc., Silver Spring, MD.


Illinois Adult Education Bridges: Promising Practices. Transition Highlights. Issue 4  

ERIC Educational Resources Information Center

To enhance state-level adult education and employment policy, in 2007 the Joyce Foundation began the Shifting Gears (SG) initiative to assist six states (Illinois, Indiana, Michigan, Minnesota, Ohio and Wisconsin) to integrate adult education, workforce development and postsecondary education policies and improve job opportunities for low-skilled…

Bragg, Debra; Oertle, Kathleen Marie; Kim, Sujung; Kirby, Catherine; Taylor, Jason; Harmon, Tim; Liss, Loralea



Implementing Promising Practices to Prepare Quality Teacher Educators  

ERIC Educational Resources Information Center

The United States does more than just talk; it invests a lot of money in public education. While students are the major focus of concern, teachers are a mainstay in the enterprise. In 2002, the U.S. invested $192 billion in teacher pay and benefits. More than 50% of all dollars allocated by the government for education is paid in salaries for…

Gentry, Ruben



Promising Practices in Using the Internet to Teach Social Studies  

ERIC Educational Resources Information Center

This article presents several teachers and school Web sites that offer teaching strategies in using the Internet to teach social sciences. These Web sites include: (1) Mrs. Cori Culp's Website (; (2) Mr. Williams's 5th Grade(; (3) Ms. Stewart's Classroom Page…

Risinger, C. Frederick



Promising Practices in Career and Technology Studies (CTS).  

ERIC Educational Resources Information Center

This document contains profiles of 130 successful programs and partnerships in Career and Technology Studies (CTS) in Alberta, Canada. Following an introduction to the CTS program and its implementation, the profiles are organized into 23 sections that follow the strands of the program. The sections cover the following topics: CTS general;…

Alberta Learning, Edmonton. Learning and Teaching Resources Branch.


Campus Security: A First Look at Promising Practices.  

ERIC Educational Resources Information Center

This booklet is designed to assist colleges and universities as they develop policies, procedures, and programs to increase safety, respond appropriately to victims of crime, and fully comply with federal requirements established by the Crime Awareness and Campus Security Act of 1990. Part 1 presents 11 topics for helping define comprehensive,…

Kirkland, Connie J.; Siegel, Dorothy G.



EPA Science Inventory

Epidemiology has been considered the fundamental science of public health policy. The use of epidemiologic data in environmental health policy has been limited particularly in the environmental regulatory arena. Epidemiologic risk assessment (ERA) is different from risk ass...


Early Commitment Financial Aid Programs: Promises, Practices, and Policies  

ERIC Educational Resources Information Center

Student financial assistance has long been a means to promote access to postsecondary education and attainment of college degrees. Numerous types of financial aid programs have proliferated over the years, including a relatively new concept that specifically targets high-risk, low-income students, focusing not just on getting them to go to college…

Blanco, Cheryl D.



Curriculum Integration. Center for School Success Promising Practices Series  

ERIC Educational Resources Information Center

This publication focuses on curriculum integration. Integrative curriculum focuses on a theme or themes upon which two or more disciplines is organized. Curriculum integration has been proposed as a way of organizing the life skills, or "common learnings," considered essential for citizens in a democracy. The curriculum is organized around…

Imbimbo, Josephine; Knopf, Naomi



Block Scheduling: Center for School Success Promising Practices Series  

ERIC Educational Resources Information Center

This publication focuses on block scheduling. Alternative scheduling models--usually called "block scheduling" because they involve blocks of time for student learning--restructure the school day. Schools may adopt block scheduling to create more productive and personal relationships among teachers and students, to design challenging curricula…

Imbimbo, Josephine; Gilkes, Alwyn



Identifying Plane Figures  

NSDL National Science Digital Library

Here you can practice identifying triangles, quadrilaterals and other polygons. Spring training is here so work on you baseball skills while studying your math! Baseball Angle Review and Baseball Triangle Practice will help your game in and out of the classroom. Make Benchmark a breeze with the Quadrilateral Sorter. ...

West, Mrs.



The (non)comparability of the correlation effect size across different measurement procedures: a challenge to meta-analysis as a tool for identifying "evidence based practices".  


Meta-analysis is becoming a principal tool for research synthesis and for the identification and justification of evidence based practices. A fundamental assumption in meta-analysis is that effect sizes based upon different measures are comparable. Recent work has challenged this assumption in the case of the standardized mean difference. In this article it is shown that population universe (true) score level correlation effect sizes, for the relationship between two constructs A and B, based upon different measures will be comparable only if construct validity invariance holds across the measures used to make inferences to A and the measures used to make inferences to B. The results of a simulation study are also reported which show that the results of a meta-analysis may be significantly and adversely affected by violations of construct validity invariance. Finally, it is concluded that the theoretical results obtained in this article, and the results of the simulation study, combine to suggest that the role of meta-analysis in the synthesis of social work research, and in the identification of evidence based practices, be de-emphasized until important questions about the sensitivity of meta-analysis to violations of construct validity invariance are answered. PMID:21660822

Nugent, William R



K-12 and University Educators Working Together toward Change: Initiating a Conversation about Practice  

ERIC Educational Resources Information Center

This case study of a joint school/university professional development opportunity explored how 12 practitioners came together to examine change in light of discrepancies between current practice in local schools and promising practices recommended in the literature for students identified as having significant disabilities. The group met monthly…

Fisher, Mary; Rogan, Patricia M.



A Practice/Research Collaborative: An Innovative Approach to Identifying and Responding to Psychosocial Functioning Problems and Recidivism Risk among Juvenile Arrestees  

ERIC Educational Resources Information Center

Effectively identifying and responding to the psychosocial problems and recidivism risk of arrested youths remain critical needs in the field. Centralized intake facilities, such as juvenile assessment centers (JACs), can play a key role in this process. As part of a U.S. National Demonstration Project, the Miami-Dade JAC, serving a…

Dembo, Richard; Walters, Wansley; Meyers, Kathleen



Cultural Neuroscience: Progress and Promise  

PubMed Central

The nature and origin of human diversity has been a source of intellectual curiosity since the beginning of human history. Contemporary advances in cultural and biological sciences provide unique opportunities for the emerging field of cultural neuroscience. Research in cultural neuroscience examines how cultural and genetic diversity shape the human mind, brain and behavior across multiple time scales: situation, ontogeny and phylogeny. Recent progress in cultural neuroscience provides novel theoretical frameworks for understanding the complex interaction of environmental, cultural and genetic factors in the production of adaptive human behavior. Here, we provide a brief history of cultural neuroscience, theoretical and methodological advances, as well as empirical evidence of the promise of and progress in the field. Implications of this research for population health disparities and public policy are discussed.

Chiao, Joan Y.; Cheon, Bobby K.; Pornpattanangkul, Narun; Mrazek, Alissa J.; Blizinsky, Katherine D.



Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer  

Microsoft Academic Search

Biomarkers have the potential to significantly change diagnostic strategies and influence therapeutic management. We developed a MALDI-TOF protein expression profiling platform for biomarker discovery and a proof-of-principle study identified two proteins, cyclophilin A (CyPA) and macrophage migration inhibitory factor (MIF), that were overexpressed in non-small cell lung cancer (NSCLC). The current study focused on evaluating the potential of CyPA and

Brandon A. Howard; Zhong Zheng; Michael J. Campa; Michael Z. Wang; Anupama Sharma; Eric Haura; James E. Herndon; Michael C. Fitzgerald; Gerold Bepler; Edward F. Patz



Present but not accounted for: exploring the sexual risk practices and intervention needs of nonheterosexually identified women in a prevention program for women with HIV/AIDS.  


Nonheterosexually identified (NHI) women may be present, but not accounted for, in HIV and sexually transmitted infection (STI) prevention interventions. This study used quantitative and qualitative methods to examine the sexual risk behaviors and intervention needs of NHI women in Protect and Respect, a safer sex intervention for HIV-positive women. Study participants (n=32) were predominantly Black, low income, and between 28 and 51 years old. Although NHI participants were more likely than heterosexual participants (p < .05) to report obtaining their income from sex work, hustling, or selling drugs; and having a higher median number of male sex partners, qualitative analyses revealed that the intervention often neglected NHI women's experiences and unique safer sex needs. Heterosexist HIV and STI prevention programs may hinder NHI women's ability to protect themselves and their partners from reinfection and infection respectively. We discuss the implications of our research for future HIV/AIDS and STI research, services and interventions for NHI women. PMID:19042909

Teti, Michelle; Bowleg, Lisa; Rubinstein, Susan; Lloyd, Linda; Berhane, Zek; Gold, Marla



A comparison between the efficiency of the Xpert MTB/RIF assay and nested PCR in identifying Mycobacterium tuberculosis during routine clinical practice  

PubMed Central

Objectives Polymerase chain reaction (PCR) for the detection of Mycobacterium tuberculosis (MTB) is more sensitive, specific, and rapid than the conventional methods of acid-fast bacilli (AFB) smear and culture. The aim of this study was to determine if the Xpert MTB/rifampicin (RIF) assay had additional advantages over nested PCR for the detection of MTB in a geographical area with intermediate tuberculosis (TB) incidence. Methods Between February and December 2013, the Xpert MTB/RIF assay and MTB nested PCR, as well as AFB smear and culture, were simultaneously performed on 198 clinical samples (160 pulmonary and 38 non-pulmonary specimens) collected from 171 patients hospitalized at Hallym University Medical Center for possible TB. The accuracy of the diagnosis of MTB culture-positive TB and the turnaround time of reporting laboratory results were calculated and compared. Rifampin resistance by the Xpert MTB/RIF assay was reviewed with that of conventional drug susceptibility testing (DST). Results The sensitivity, specificity, and positive and negative predictive values of the Xpert MTB/RIF assay and MTB nested PCR for diagnosis of MTB culture-positive pulmonary TB were 86.1% vs. 69.4% (P=0.1563), 97.8% vs. 94.1% (P=0.2173), 91.2% vs. 75.8% (P=0.1695), and 96.4% vs. 92.0% (P=0.2032), respectively. The median turnaround times of the Xpert MTB/RIF assay and MTB nested PCR were 0 [0-4] days and 4 [1-11] days, respectively (P<0.001). Two cases of rifampin resistance, as determined by the Xpert MTB/RIF assay, were found to be multi-drug resistant (MDR) pulmonary TB by DST. Conclusions The Xpert MTB/RIF assay seemed to be sensitive, specific, and comparable to nested PCR for identifying MTB among clinically suspected TB patients, and the assay can be valuable in giving a timely identification of resistance to rifampin.

Kim, Cheol-Hong; Woo, Heungjeong; Kim, Changhwan; Choi, Jeong-Hee; Jang, Seung-Hun; Park, Sang Myeon; Lee, Myung Goo; Jung, Ki-Suck; Hyun, Jeongwon; Kim, Hyun Soo



Multiple sclerosis: Prospects and promise.  


We have entered a golden era in multiple sclerosis (MS) research. Two decades ago, our understanding of the disease was largely descriptive and there were no approved therapies to modify the natural history of MS. Today, delineation of immune pathways relevant to MS have been clarified; a comprehensive map of genes that influence risk compiled; clues to environmental triggers identified; noninvasive in vivo monitoring of the MS disease process has been revolutionized by high-field MRI; and many effective therapies for the early, relapsing, component of MS now exist. However, major challenges remain. We still have no useful treatment for progressive MS (the holy grail of MS research), no means to repair injured axons or protect neurons, and extremely limited evidence to guide treatment decisions. Recent advances have set in place a foundation for development of increasingly selective immunotherapy for patients; application of genetic and genomic discoveries to improve therapeutic options; development of remyelination or neuroprotection therapies for progressive MS; and integrating clinical, imaging and genomic data for personalized medicine. MS has now advanced from the backwaters of autoimmune disease research to the front-line, and definitive answers, including cures, are now realistic goals for the next decade. Many of the breakthrough discoveries in MS have also resulted from meaningful interactions across disciplines, and especially from translational and basic scientists working closely with clinicians, highlighting that the clinical value of discoveries are most often revealed when ideas developed in the laboratory are tested at the bedside. PMID:23955638

Hauser, Stephen L; Chan, Jonah R; Oksenberg, Jorge R



The promise of riboswitches as potential antibacterial drug targets.  


Riboswitches represent promising novel RNA structures for developing compounds that artificially regulate gene expression and, thus, bacterial growth. The past years have seen increasing efforts to identify metabolite-analogues which act on riboswitches and which reveal antibacterial activity. Here, we summarize the current inventory of riboswitch-targeting compounds, their characteristics and antibacterial potential. PMID:24140145

Lünse, Christina E; Schüller, Anna; Mayer, Günter



DNA chips: promising toys have become powerful tools  

Microsoft Academic Search

DNA chips are glass surfaces that represent thousands of DNA fragments arrayed at discrete sites. Hybridization of RNA or DNA-derived samples to DNA chips allows us to monitor expression of mRNAs or the occurrence of polymorphisms in genomic DNA. The technology holds great promise for identifying gene polymorphisms that predispose man to disease, gene regulation events involved in disease progression,

David Gerhold; Thomas Rushmore; C. Thomas Caskey



Estimating Animal Abundance Using Noninvasive DNA Sampling: Promise and Pitfalls  

Microsoft Academic Search

Advances in molecular biology offer promise to the study of demographic characteristics of rare or hard-to-capture species, because individuals can now be identified through noninvasive sampling such as fecal collection or hair snags. However, individual genotyping using such methods currently leads to a novel problem that we call a ''shadow effect,'' because some animals not captured previously are believed to

L. Scott Mills; John J. Citta; Kevin P. Lair; Michael K. Schwartz; David A. Tallmon



Identifying Rural Tourism Markets: A Practical Tool  

Microsoft Academic Search

Product attributes of rural tourism are inherently green, and have the potential to appeal to the increasingly overstretched consumers who are in search for a personalized response to their need for physical, emotional, and social appreciation in a simpler environment. The same consumers also become more independent, involved, and discriminatory in the destination selection process. Despite their rich green assets,

Liping A. Cai; Jingrong Liu; Zhuowei Huang



Identifying and Managing Risk.  

ERIC Educational Resources Information Center

The role of the college or university chief financial officer in institutional risk management is (1) to identify risk (physical, casualty, fiscal, business, reputational, workplace safety, legal liability, employment practices, general liability), (2) to develop a campus plan to reduce and control risk, (3) to transfer risk, and (4) to track and…

Abraham, Janice M.



Cancer and Inflammation: Promise for Biological Therapy  

PubMed Central

Cancers often arise as the end stage of inflammation in adults, but not in children. As such there is a complex interplay between host immune cells during neoplastic development, with both an ability to promote cancer as well as limit or eliminate it, most often complicit with the host. In humans, defining inflammation and the presence of inflammatory cells within or surrounding the tumor is a critical aspect of modern pathology. Groups defining staging for neoplasms are strongly encouraged to assess and incorporate measures of the presence of apoptosis, autophagy, and necrosis as well as the nature and quality of the immune infiltrate. Both environmental as well as genetic factors enhance the risk of cigarette smoking, H. pylori, hepatitis B/C, human papilloma virus, solar irradiation, asbestos, pancreatitis, or other causes of chronic inflammation. Identifying suitable genetic polymorphisms in cytokines, cytokine receptors, and Toll-like receptors among other immune response genes is also seen as high value as genomic sequencing becomes less expensive. Animal models which incorporate and assess not only the genetic anlagen but also the inflammatory cells and the presence of microbial pathogen [PAMPs] and damage associated molecular pattern molecules [DAMPs] are necessary. Identifying micro-RNAs involved in regulating the response to damage or injury are seen as highly promising. Although no therapeutic strategies to prevent or treat cancers based on insights into inflammatory pathways are currently approved for the common epithelial malignancies, there remains substantial interest in agents targeting COX2 or PPAR?, ethyl pyruvate, as well as steroids and several novel agents on the horizon.

Demaria, Sandra; Pikarsky, Eli; Karin, Michael; Coussens, Lisa M.; Chen, Yen-Ching; El-Omar, Emad M.; Trinchieri, Giorgio; Dubinett, Steven M.; Mao, Jenny T.; Szabo, Eva; Krieg, Arthur; Weiner, George J.; Fox, Bernard A.; Coukos, George; Wang, Ena; Abraham, Robert T.; Carbone, Michele; Lotze, Michael T.



Glucokinase activators (GKAs) promise a new pharmacotherapy for diabetics  

PubMed Central

The glucose-phosphorylating enzyme glucokinase, a promising target for developing new antidiabetic agents, was identified through the combined efforts of basic research and human biochemical genetics. Allosteric glucokinase activators (GKAs) were discovered by high-throughput screening of a large compound library and first reported in 2003. GKAs stimulate insulin release and glucose metabolism in the liver thereby lowering blood sugar, and promising trials in humans demonstrate that they are highly effective in patients with type 2 diabetes mellitus. Many companies are now attempting to develop effective and safe GKAs for treating diabetics.

Porte, Daniel



Identify Symmetry  

NSDL National Science Digital Library

This unit will teach you how to identify symmetry in everyday objects and mathematical shapes in lines and rotational symmetry. What is line symmetry? Click on the link to find out: Line Symmetry Here is a line activity to see if you understand it: Line Symmetry Class Zone See if you understand the concepts by doing the following quiz: Line Symmetry Work Now for rotational symmetry: Rotational Symmetry See if you understand rotational symmetry by taking this quiz: Rotational Symmetry Work ...

Neubert, Mrs.



Identifying Erosion  

NSDL National Science Digital Library

In this environmental science activity (page 3 of the PDF), leaners will identify and explain the causes of erosion. They will observe the effects of erosion on the surrounding area and further explore examples of erosion online. An extension activity allows learners to make a hands-on model of soil erosion. Though this was created as a pre-visit activity for a workshop about water flow and erosion, it makes a great stand-alone activity as well!




Inferences from counterfactual threats and promises.  


We examine how people understand and reason from counterfactual threats, for example, "if you had hit your sister, I would have grounded you" and counterfactual promises, for example, "if you had tidied your room, I would have given you ice-cream." The first experiment shows that people consider counterfactual threats, but not counterfactual promises, to have the illocutionary force of an inducement. They also make the immediate inference that the action mentioned in the "if" part of the counterfactual threat and promise did not occur. The second experiment shows that people make more negative inferences (modus tollens and denial of the antecedent) than affirmative inferences (modus ponens and affirmation of the consequent) from counterfactual threats and promises, unlike indicative threats and promises. We discuss the implications of the results for theories of the mental representations and cognitive processes that underlie conditional inducements. PMID:22580411

Egan, Suzanne M; Byrne, Ruth M J



The Promise and Reality of Pharmacogenetics in Psychiatry  

PubMed Central

Summary Existing psychotropic medications for the treatment of mental illnesses, including antidepressants, mood stabilizers, and antipsychotics, are clinically sub-optimal. They are effective in only a subset of patients or produce partial responses, and they are often associated with debilitating side effects that discourage adherence. There is growing enthusiasm in the promise of pharmacogenetics to personalize the use of these treatments to maximize their efficacy and tolerability. However, there is still a long way to go before this promise becomes a reality. In this article, we review the progress that has been made in research towards understanding how genetic factors influence psychotropic drug responses and the challenges that lie ahead in translating the research findings into clinical practices that yield tangible benefits for patients with mental illnesses.

Zandi, Peter P.; Judy, Jennifer T.



Melanoma Drug Trials Show Significant Promise  


... sharing features on this page, please enable JavaScript. Melanoma Drug Trials Show Significant Promise By targeting immune ... Monday, June 2, 2014 Related MedlinePlus Pages Medicines Melanoma MONDAY, June 2, 2014 (HealthDay News) -- A relatively ...


Adult Stem Cell Research Shows Promise  


... Tobacco Products Vaccines, Blood & Biologics Articulos en Espanol Adult Stem Cell Research Shows Promise Search the Consumer Updates Section ... re looking at a particular kind of multipotent adult stem cell—the MSC—which is being used in a ...


New Psoriasis Drug Shows Promise in Trials  


... features on this page, please enable JavaScript. New Psoriasis Drug Shows Promise in Trials Secukinumab appears more ... Wednesday, July 9, 2014 Related MedlinePlus Pages Medicines Psoriasis WEDNESDAY, July 9, 2014 (HealthDay News) -- A new ...


Pyrrolizines: Promising scaffolds for anticancer drugs.  


Pyrrolizine derivatives constitute a class of heterocyclic compounds which can serve as promising scaffolds for anticancer drugs. The unique antitumor properties of mitomycin C inspired chemists to develop different pyrrolizine systems and assess their potential antitumor activities against a wide variety of cancer types. Here we review the different classes of pyrrolizines that possess anticancer potency, with an emphasis on their structure activity relationships, in an effort to pave the way for further development in this promising area of research. PMID:24331756

Belal, Amany; El-Gendy, Bahaa El-Dien M



Identifying Elements of a Biography  

NSDL National Science Digital Library

In this resource, students will identify and describe evidence in a text showing that it is a biography. In guided and independent practice students will use A Picture Book of Anne Frank by David A. Adler.




Polymer electrolytes, problems, prospects, and promises  

SciTech Connect

Ionically conducting polymer electrolytes have generated, in recent years, wide-spread interest as candidate materials for a number of applications including high energy density and power lithium batteries. In the early 70s the first measurements of ionic conductivity in polyethylene oxide (PEO)-salt complexes were carried out. However, Armand was the first one to realize potential of these complexes (polymer-salt complexes) as practical ionically conducting materials for use as electrolytes in lithium batteries. Subsequent research efforts identified the limitations and constraints of the polymer electrolytes. These limitations include poor ionic conductivity at RT (< 10{sup {minus}8} S/cm), low cation transport number (<0.2) etc. Several different approaches have been made to improving the ionic conductivity of the polymer electrolytes while retaining the flexibility, processibility, ease of handling and relatively low impact on the environment that polymers inherently possess. This paper- reviews evolution of polymer electrolytes from conventional PEO-LiX slat complexes to the more conducting polyphosphazene and copolymers, gelled electrolytes etc. We also review the various chemical approaches including modifying PEO to synthesizing complicated polymer architecture. In addition, we discuss effect of various lithium salts on the conductivity of PEO-based polymers. Charge/discharge and cycle life data of polymer cells containing oxide and chalcogenide cathodes and lithium (Li) anode are reviewed. Finally, future research directions to improve the electrolyte properties are discussed.

Nagasubramanian, G.; Boone, D.



Implementing Evidence-Based Social Work Practice  

ERIC Educational Resources Information Center

Recently, social work has been influenced by new forms of practice that hold promise for bringing practice and research together to strengthen the scientific knowledge base supporting social work intervention. The most recent new practice framework is evidence-based practice. However, although evidence-based practice has many qualities that might…

Mullen, Edward J.; Bledsoe, Sarah E.; Bellamy, Jennifer L.



Defining Normal and Abnormal Fetal Growth: Promises and Challenges  

PubMed Central

Normal fetal growth is a critical component of a healthy pregnancy and influences the long-term health of the offspring. However, defining normal and abnormal fetal growth has been a long-standing challenge in clinical practice and research. The authors review various references and standards that are widely used to evaluate fetal growth, and discuss common pitfalls of current definitions of abnormal fetal growth. Pros and cons of different approaches to customize fetal growth standards are described. The authors further discuss recent advances towards an integrated definition for fetal growth restriction. Such a definition may incorporate fetal size with the status of placental health measured by maternal and fetal Doppler velocimetry and biomarkers, biophysical findings and genetics. Although the concept of an integrated definition appears promising, further development and testing are required. An improved definition of abnormal fetal growth should benefit both research and clinical practice.

Zhang, Jun; Merialdi, Mario; Platt, Lawrence D.; Kramer, Michael S.



Do promises matter? An exploration of the role of promises in psychological contract breach.  


Promises are positioned centrally in the study of psychological contract breach and are argued to distinguish psychological contracts from related constructs, such as employee expectations. However, because the effects of promises and delivered inducements are confounded in most research, the role of promises in perceptions of, and reactions to, breach remains unclear. If promises are not an important determinant of employee perceptions, emotions, and behavioral intentions, this would suggest that the psychological contract breach construct might lack utility. To assess the unique role of promises, the authors manipulated promises and delivered inducements separately in hypothetical scenarios in Studies 1 (558 undergraduates) and 2 (441 employees), and they measured them separately (longitudinally) in Study 3 (383 employees). The authors' results indicate that breach perceptions do not represent a discrepancy between what employees believe they were promised and were given. In fact, breach perceptions can exist in the absence of promises. Further, promises play a negligible role in predicting feelings of violation and behavioral intentions. Contrary to the extant literature, the authors' findings suggest that promises may matter little; employees are concerned primarily with what the organization delivers. PMID:19702368

Montes, Samantha D; Zweig, David



Advanced available-to-promise: Classification, selected methods and requirements for operations and inventory management  

Microsoft Academic Search

Advanced available-to-promise (AATP) comprises of an assortment of methods and tools to enhance order promising responsiveness and order fulfillment reliability. This paper contributes to a theoretical framework for the development of models and algorithms supporting order quantity and due date quoting. At first, alternative generic AATP systems will be identified on the basis of relevant classification criteria. Based upon this

Richard Pibernik



Problems and promises of the protocol  

Microsoft Academic Search

Creating protocols (or guidelines, standards) for medical work is becoming big business. The pros and cons of protocols have been reiterated many times: advocates argue that protocols may enhance the quality of care, reduce unwanted variations in practice, and may help to render medical practice more scientific. Critics, on the contrary, argue that protocols will lead to cookbook medicine, to

Marc Berg



The (Unfulfilled) Promise of Critical Pedagogy  

ERIC Educational Resources Information Center

In this article the author examines theory, research, and theory into practice literature from the critical/social reconstructionist orientation as it relates to teacher education and classroom practice in social studies education. A critical perspective is explored from several angles including its historical development; its definition; its…

Evans, Ronald W.



GEOTEC-a promising energy alternative  

Microsoft Academic Search

Geothermal reconnaissance has shown a promising resource at the base of three clustered volcanoes on Adak Island, located along the Aleutian arc of Alaska. Geophysical surveys revealed areas of abrupt and steep gravitational gradients and high electrical conductivity over the volcanoes, indicating possible subsurface magma. Geochemical analyses indicated a potential reservoir temperature of 180°C. The nearby Bering Sea has a

C. S. Gerrard; G. H. Gelb; A. Lowrie



Promise in Action: Examples of Institutional Success  

ERIC Educational Resources Information Center

In this article, the author illustrates how three campuses have, in their own way, attempted to bring coherence to the student experience and enrich that experience by more closely matching what was promised to what each student actually experiences while enrolled. Fulfilling students' expectations that were purposefully articulated in the mission…

Kuh, George D.



Alcohol Research: Promise for the Decade.  

ERIC Educational Resources Information Center

Over the past 20 years, alcohol researchers have made intensive efforts to understand alcohol use and its outcomes. To date, researchers have made much progress toward understanding the causes and consequences of alcoholism and its related problems. This publication attempts to convey the great spirit and promise of alcohol research. Established…

Gordis, Enoch


The Promises of Moral Foundations Theory  

ERIC Educational Resources Information Center

In this article I examine whether Moral Foundations Theory can fulfil the promises that Haidt claims for the theory: that it will help in developing new approaches to moral education and to the moral conflicts that divide our diverse society. I argue that, first, the model that Haidt suggests for understanding the plurality of moralities--a shared…

Musschenga, Bert



Social Conventions to Promise Learning Convergence  

Microsoft Academic Search

Convergence is an important problem in the current learning algorithms for multi-agent system. The diversity of solutions causes it difficult for all agents in the system to unify their selections. The social conventions are prompted for the system during learning, which will help deciding the unique game solution for the system and promising the learning convergence therefore.

Meiping Song; Rong Chen; An Jubai



Implementing Performance Assessment: Promises, Problems, and Challenges.  

ERIC Educational Resources Information Center

The chapters in this collection contribute to the debate about the value and usefulness of radically different kinds of assessments in the U.S. educational system by considering and expanding on the theoretical underpinnings of reports and speculation. The chapters are: (1) "Assessment Reform: Promises and Challenges" (Nidhi Khattri and David…

Kane, Michael B., Ed.; Mitchell, Ruth, Ed.


The Promise of Wave Power (Invited)  

Microsoft Academic Search

The solutions to today's energy challenges need to be explored through alternative, renewable and clean energy sources to enable diverse energy resource plans. An extremely abundant and promising source of energy exists in the world's oceans: it is estimated that if 0.2 % of the oceans' untapped energy could be harnessed, it could provide power sufficient for the entire world.

T. Brekken



Promise and Pitfalls of Using Grain Size Analysis to Identify Glacial Sediments in Alpine Lake Cores.  

NASA Astrophysics Data System (ADS)

Lakes fed by glacier outwash should have a clastic particle-size record distinct from non-glacial lakes in the same area, but do they? The unique turquoise color of alpine glacial lakes reflects the flux of suspended clastic glacial rock flour to those lakes; conversely, lakes not fed by outwash are generally clear with sediments dominated by organics or slope-wash from nearby hillslopes. This contrast in sediment types and sources should produce a distinct and measureable different in grain sizes between the two settings. Results from a variety of lakes suggest the actual situation is often more subtle and complex. I compare grain size results to other proxies to assess the value of grain size analysis for paleoglacier studies. Over the past 10 years, my colleagues and I have collected and analyzed sediment cores from a wide variety of lakes below small alpine glaciers in an attempt to constrain the timing and magnitude of alpine glaciation in those basins. The basic concept is that these lakes act as continuous catchments for any rock flour produced upstream by glacier abrasion; as a glacier grows, the flux of rock flour to the lake will also increase. If the glacier disappears entirely, rock flour deposition will also cease in short order. We have focused our research in basins with simple sedimentologic settings: mostly small, high-altitude, stripped granitic or metamorphic cirques in which the cirque glaciers are the primary source of clastic sediments. In most cases, the lakes are fed by meltwater from a modern glacier, but were ice free during the earlier Holocene. In such cases, the lake cores should record formation of and changes in activity of the glacier upstream. We used a Malvern Mastersizer 2000 laser particle size analyzer for our grain size analyses, as well as recording magnetic susceptibility, color, and organics for the same cores. The results indicate that although lakes often experience increases in silt and clay-size (<0.63 mm) clastic particles when a glacier is present upstream, the signal can be highly variable and complex, most likely the result of stochastic processes in the basin. Our analyses indicate that although particle size reflects glacier activity upstream, it is rarely the best record of glacier change and is most useful in combination with other proxies, most notably MS, color, and organic content.

Clark, D. H.



The Promise of Standardized Data Collection: School Health Variables Identified by States  

ERIC Educational Resources Information Center

A gap in data prevents measurement of the needs of school-age children and the influence of school nursing interventions on student health and education outcomes. Its remedy is in the data collected in school health rooms. A national clinical database describing school health will allow education and health leaders to build evidence-based programs…

Johnson, Kathleen H.; Bergren, Martha Dewey; Westbrook, Linda Oakes



Promising Aedes aegypti repellent chemotypes identified through integrated QSAR, virtual screening, synthesis, and bioassay.  


Molecular field topology analysis, scaffold hopping, and molecular docking were used as complementary computational tools for the design of repellents for Aedes aegypti, the insect vector for yellow fever, chikungunya, and dengue fever. A large number of analogues were evaluated by virtual screening with Glide molecular docking software. This produced several dozen hits that were either synthesized or procured from commercial sources. Analysis of these compounds by a repellent bioassay resulted in a few highly active chemicals (in terms of minimum effective dosage) as viable candidates for further hit-to-lead and lead optimization effort. PMID:24039693

Oliferenko, Polina V; Oliferenko, Alexander A; Poda, Gennadiy I; Osolodkin, Dmitry I; Pillai, Girinath G; Bernier, Ulrich R; Tsikolia, Maia; Agramonte, Natasha M; Clark, Gary G; Linthicum, Kenneth J; Katritzky, Alan R



Promising Aedes aegypti Repellent Chemotypes Identified through Integrated QSAR, Virtual Screening, Synthesis, and Bioassay  

PubMed Central

Molecular field topology analysis, scaffold hopping, and molecular docking were used as complementary computational tools for the design of repellents for Aedes aegypti, the insect vector for yellow fever, chikungunya, and dengue fever. A large number of analogues were evaluated by virtual screening with Glide molecular docking software. This produced several dozen hits that were either synthesized or procured from commercial sources. Analysis of these compounds by a repellent bioassay resulted in a few highly active chemicals (in terms of minimum effective dosage) as viable candidates for further hit-to-lead and lead optimization effort.

Oliferenko, Polina V.; Oliferenko, Alexander A.; Poda, Gennadiy I.; Osolodkin, Dmitry I.; Pillai, Girinath G.; Bernier, Ulrich R.; Tsikolia, Maia; Agramonte, Natasha M.; Clark, Gary G.; Linthicum, Kenneth J.; Katritzky, Alan R.



School Dropouts: Education Could Play a Stronger Role in Identifying and Disseminating Promising Prevention Strategies.  

National Technical Information Service (NTIS)

Over the last decade, between 347,000 and 544,000 10th- through 12th-grade students dropped out of school each year without successfully completing a high school program. In October 2000, about 11 percent of 16- through 24-year-olds who were not enrolled ...



Identifying Equivalent Fractions  

NSDL National Science Digital Library

This site helps students understand how to identify equivalent fractions by explaining what equivalent fractions are and how to compare two fractions to see if they are equivalent. There is also a list of fractions equivalent to 1/2, 1/3, 1/4, 1/5, and 2/5 so students can begin to see the pattern that emerges. Finally, the site presents an interactive game in which students can practice by naming the equivalent fraction to a given fraction.

Banfill, J. C.



The promise of molecular epidemiology in defining the association between radiation and cancer  

SciTech Connect

Molecular epidemiology involves the inclusion in epidemiologic studies of biologic measurements made at a genetic and molecular level and aims to improve the current knowledge of disease etiology and risk. One of the goals of molecular epidemiology studies of cancer is to determine the role of environmental and genetic factors in initiation and progression of malignancies and to use this knowledge to develop preventive strategies. This approach promises extraordinary opportunities for revolutionizing the practice of medicine and reducing risk. However, this will be accompanied by the need to address and resolve many challenges, such as ensuring the appropriate interpretation of molecular testing and resolving associated ethical, legal, and social issues. Traditional epidemiologic approaches determined that exposure to ionizing radiation poses significantly increased risk of leukemia and several other types of cancer. Such studies provided the basis for setting exposure standards to protect the public and the workforce from potentially adverse effects of ionizing radiation. These standards were set by using modeling approaches to extrapolate from the biological effects observed in high-dose radiation studies to predicted, but mostly immeasurable, effects at low radiation doses. It is anticipated that the addition of the molecular parameters to the population-based studies will help identify the genes and pathways characteristic of cancers due to radiation exposure of individuals, as well as identify susceptible or resistant subpopulations. In turn, the information about the molecular mechanisms should aid to improve risk assessment. While studies on radiogenic concerns are currently limited to only a few candidate genes, the exponential growth of scientific knowledge and technology promises expansion of knowledge about identity of participating genes and pathways in the future. This article is meant to provide an introductory overview of recent advances in understanding of carcinogenesis at the molecular level, with an emphasis of the aspects that may be of use in establishing the association between radiation and cancer.

Neta, R.



The Promise of Wave Power (Invited)  

NASA Astrophysics Data System (ADS)

The solutions to today's energy challenges need to be explored through alternative, renewable and clean energy sources to enable diverse energy resource plans. An extremely abundant and promising source of energy exists in the world's oceans: it is estimated that if 0.2 % of the oceans' untapped energy could be harnessed, it could provide power sufficient for the entire world. Ocean energy exists in the forms of wave, tidal, marine currents, thermal (temperature gradient) and salinity. Among these forms, significant opportunities and benefits have been identified in the area of ocean wave energy extraction, i.e., harnessing the motion of the ocean waves, and converting that motion into electrical energy. Ocean wave energy refers to the kinetic and potential energy in the heaving motion of ocean waves. Wave energy is essentially concentrated solar energy (as is wind energy). The heating of the earth’s surface by the sun (with other complex processes) drives the wind, which in turn blows across the surface of the ocean to create waves. At each stage of conversion, the power density increases. Ocean wave power offers several attractive qualities, including high power density, low variability, and excellent forecastability. A typical large ocean wave propogates at around 12 m/s with very little attenuation across the ocean. If the waves can be detected several hundred kilometers off shore, there can be 10 hours or more of accurate forecast horizon. In fact, analysis has shown good forecast accuracy up to 48 hours in advance. Off the coast Oregon, the yearly average wave power is approximately 30 kW per meter of crestlength (i.e., unit length transverse to the direction of wave propagation and parallel to the shore.) This compares very favorably with power densities of solar and wind, which typically range in the several hundreds of Watts per square meter. Globally, the wave energy resource is stronger on the west coasts of large landmasses and increases in strength toward the poles. This phenomenon is due to the prevailing west to east global winds known as the "westerlies" found in the Northern and Southern hemispheres between 30 and 60 degrees latitude. Correspondingly, the west coast of the United States, the west coast of Australia, and the coastal regions of Europe have seen the greatest wave energy industrial activity to date. Ocean wave energy has great potential to be a significant contributor of renewable power for many regions in the world. For the West coast of the US alone, the total wave energy resource is estimated at 440 TWh/yr, which is more than the typical total US annual hydroelectric production (270 TWh in 2003). For US west coast states, a fully developed wave energy industry could be a significant contributor to renewable energy portfolio standards. Within the next few years, several utility-scale wave energy converters are planned for grid connection (e.g., Ocean Power Technologies and Columbia Power Technologies in Oregon, USA), with plans for more utility-scale development to follow soon after. This presentation will cover the physical basics of wave energy, examples of commercial technology, challenges opportunities for research, and an update on the wave energy research and developments at leading commercial, industrial, and academic institutions around the world.

Brekken, T.



Thiomers: promising platform for macromolecular drug delivery.  


The application of macromolecules as therapeutic agents holds great promise for several major disorders such as cancer and cardiovascular disease. However, their use is limited by the lack of efficient, safe and specific delivery strategies. A promising strategy to overcome these challenges might be the use of thiolated polymers or designated thiomers. Thiomers are synthesized by immobilization of sulfhydryl bearing ligands on a polymeric backbone of well-established polymers. These multifunctional polymeric excipients show advantages in mucoadhesion, enzyme and efflux pump inhibition in comparison to unmodified polymers. One obstacle in the use of thiomers is that they are prone to oxidation at lower pH but this could be solved by introducing a completely new generation of thiomers, namely, the preactivated thiomer generation. Preactivated thiomers are mixed disulfides, which exhibit oxidation resistance and, beyond that, improved thiomer features. This review summarizes recent findings of polymeric excipients for macromolecular drug delivery as well as their synthesis and distinctive features. PMID:23190108

Laffleur, Flavia; Bernkop-Schnürch, Andreas



Foundations, promises and uncertainties of personalized medicine.  


Personalized medicine introduces the promise to use molecular markers that signal the risk of disease or its presence before clinical signs and symptoms appear. This information underlies a new healthcare strategy focused on prevention and early intervention, rather than reaction to advanced stages of disease. Such a strategy can delay disease onset or minimize symptom severity. The molecular foundations that enable personalized medicine include detection of variation in nucleotide sequence of genes and in characteristic patterns of gene expression, proteins and metabolites. Genetic and molecular patterns are correlated with disease manifestations, drug responses, treatment prognosis, or prediction of predisposition to future disease states. However, the uncertainties for personalized medicine are considerable, including economic, ethical, legal, and societal questions. Although much of its promise remains unproven to date, the foundations of personalized medicine appear solid and evidence is accumulating rapidly pointing to its growing importance in healthcare (Fig. 1). PMID:17516562

Bottinger, Erwin P



Pharmacogenomics: will the promise be fulfilled?  

PubMed Central

Tools such as genome resequencing and genome-wide association studies have recently been used to uncover a number of variants that affect drug toxicity and efficacy, as well as potential drug targets. But how much closer are we to incorporating pharmacogenomics into routine clinical practice? Five experts discuss how far we have come, and highlight the technological, informatics, educational and practical obstacles that stand in the way of realizing genome-driven medicine.

Altman, Russ B.; Kroemer, Heyo K.; McCarty, Catherine A.; Ratain, Mark J.; Roden, Dan



Retinoids in nephrology: Promises and pitfalls  

Microsoft Academic Search

Retinoids in nephrology: Promises and pitfalls.BackgroundRetinoids, a family of vitamin A metabolites or analogs, play an important role in regulating cell proliferation, differentiation, and apoptosis.MethodsThe biological importance of retinoids in the kidney and the potential of retinoids in the treatment of renal diseases are reviewed.ResultsVitamin A deficiency and mutations of retinoid nuclear receptors cause abnormalities in fetal kidneys, which might




Antimicrobial peptides: promising compounds against pathogenic microorganisms.  


In the last decades, the indiscriminate use of conventional antibiotics has generated high rates of microbial resistance. This situation has increased the need for obtaining new antimicrobial compounds against infectious diseases. Among these, antimicrobial peptides (AMPs) constitute a promising alternative as therapeutic agents against various pathogenic microbes. These therapeutic agents can be isolated from different organisms, being widespread in nature and synthesized by microorganisms, plants and animals (both invertebrates and vertebrates). Additionally, AMPs are usually produced by a non-specific innate immune response. These peptides are involved in the inhibition of cell growth and in the killing of several microorganisms, such as bacteria, fungi, enveloped viruses, protozoans and other parasites. They have many interesting properties as potential antibiotics, such as relatively small sizes (below 25-30 kDa), amphipathic structures, cationic nature, and offer low probability for the generation of microbial resistance. In recent years, many novel AMPs, with very promising therapeutic properties, have been discovered. These peptides have been the base for the production of chemical analogs, which have been designed, chemically synthesized and tested in vitro for their antimicrobial activity. This review is focused on antibacterial (against Gram (-) and Gram (+) bacteria) and antifungal peptides, discussing action mode of AMPs, and recent advances in the study of the molecular basis of their anti-microbial activity. Finally, we emphasize on their current pharmacological development, future directions and applications of AMPs as promising antibiotics of therapeutic use for microbial infections. PMID:24533812

Cruz, J; Ortiz, C; Guzmán, F; Fernández-Lafuente, R; Torres, R



Selection of promising sites for magma energy experiments  

SciTech Connect

The Long Valley and Coso Hot Springs areas of California have been identified as the most promising sites for conducting a magma energy extraction experiment. These two locations were selected from among the potential sites on the basis of several factors that are critical to the success of the proposed long-term energy extraction experiment. These factors include the likelihood of the existence of shallow magma targets as well as several other drilling, energy extraction and programmatic considerations. As the magma energy extraction program continues, these sites will be analyzed in detail so that one can be selected as the site for the planned magma experiment.

Carson, C.C.



Turning Ideas into Practice  

ERIC Educational Resources Information Center

This article features five schools (John P. Oldham Elementary, Norwood, Massachusetts; R. J. Richey Elementary, Burnet, Texas; Pittsburgh Carmalt Science and Technology Academy, Pittsburgh, Pennsylvania; John D. Shaw Elementary, Wasilla, Alaska; and Springville K-8, Portland Oregon) that offer five promising practices. From fourth graders learning…

Adams, Caralee



76 FR 55889 - Reopening Notice: Promise Neighborhoods Program-Implementation Grant Competition; Promise...  

Federal Register 2010, 2011, 2012, 2013

...Neighborhoods Program--Implementation Grant Competition; Promise Neighborhoods Program--Planning Grant Competition AGENCY: Office of Innovation and Improvement...Education (Department) reopens the competition for transmittal of applications...



Towards quantum-enhanced precision measurements: Promise and challenges  

NASA Astrophysics Data System (ADS)

Quantum metrology holds the promise of improving the measurement precision beyond the limit of classical approaches. To achieve such enhancement in performance requires the development of quantum estimation theories as well as novel experimental techniques. In this article, we provide a brief review of some recent results in the field of quantum metrology. We emphasize that the unambiguous demonstration of the quantum-enhanced precision needs a careful analysis of the resources involved. In particular, the implementation of quantum metrology in practice requires us to take into account the experimental imperfections included, for example, particle loss and dephasing noise. For a detailed introduction to the experimental demonstrations of quantum metrology, we refer the reader to another article ‘Quantum metrology’ in the same issue.

Zhang, Li-Jian; Xiao, Min



The Promise and Perils of Stem Cell Therapeutics  

PubMed Central

Stem cells are the seeds of tissue repair and regeneration and a promising source for novel therapies. However, apart from hematopoietic stem cell (HSC) transplantation for hematologic disease, essentially all other stem cell treatments remain experimental. High hopes have inspired numerous clinical trials, but it has been difficult to obtain unequivocal evidence for robust clinical benefit, likely owing to our primitive state of knowledge about therapeutic mechanisms. Outside the standard clinical trial network unproven therapies are being widely practiced in an open market, which threatens the cause of legitimate clinical investigation of the safety and efficacy of stem cell interventions. Here is one practitioner's perspective on the challenges and technical barriers that must be overcome for novel stem cell therapies to achieve meaningful clinical impact.

Daley, George Q.



DNA vaccination against oncoantigens: A promise.  


The emerging evidence that DNA vaccines elicit a protective immune response in rodents, dogs and cancer patients, coupled with the US Food and Drug Administration (FDA) approval of an initial DNA vaccine to treat canine tumors is beginning to close the gap between the optimistic experimental data and their difficult application in a clinical setting. Here we review a series of conceptual and biotechnological advances that are working together to make DNA vaccines targeting molecules that play important roles during cancer progression (oncoantigens) a promise with near-term clinical impact. PMID:22737607

Iezzi, Manuela; Quaglino, Elena; Amici, Augusto; Lollini, Pier-Luigi; Forni, Guido; Cavallo, Federica



Some promising dimensions for behavioral community technology  

PubMed Central

In recent years, the search for effective and replicable approaches to planned change in communities has escalated. Applied behavior analysts have participated in these efforts to remedy existing community problems and to increase the capacities of community residents to meet their goals. Examples of behavioral technologies for community settings are described and their advantages are noted. Criteria for more contextually appropriate community technologies are suggested and strategies for developing behavioral methods according to these criteria are described. This paper outlines some promising dimensions for behavioral community technology and discusses several possible limitations to a behavioral approach to addressing societal problems.

Fawcett, Stephen B.; Mathews, R. Mark; Fletcher, R. Kay



Immunology on chip: promises and opportunities.  


Microfluidics has facilitated immunological studies by enhancing speed, efficiency and sensitivity of current analysis methods. It offers miniaturization of current laboratory equipment, and enables analysis of clinical samples without the need for sophisticated infrastructure. More importantly, microfluidics offers unique capabilities; including conducting multiple serial or parallel tasks as well as providing complex and precisely controlled environmental conditions that are not achievable using conventional laboratory equipment. Microfluidics is a promising technology for fundamental and applied immunological studies, allowing generation of high throughput, robust and portable platforms, opening a new area of automation in immunology. PMID:24275489

Baratchi, Sara; Khoshmanesh, Khashayar; Sacristán, Catarina; Depoil, David; Wlodkowic, Donald; McIntyre, Peter; Mitchell, Arnan



Unleashing the Promise of Assessment for Learning  

ERIC Educational Resources Information Center

Many teachers say that they do "assessment for learning" (AfL), but often their assessment practice does not really reflect the intentions and principles that make AfL powerful. Teachers who understand the "spirit" as well as the "letter" of AfL are continually building their expertise so that they can carefully apply their professional knowledge…

Earl, Lorna; Volante, Louis; Katz, Steven




Microsoft Academic Search

The 'frequentist' approach to statistics, currently dominating statistical practice in astrophysics, is compared to the historically older Bayesian approach, which is now growing in pop- ularity in other scientic disciplines, and which provides unique, optimal solutions to well-posed problems. The two approaches address the same questions with very dieren t calculations, but in simple cases often give the same nal

T. J. Loredo



Megatrends a la pharmacy: potential and promise.  


Society is experiencing major restructuring best articulated by John Naisbitt's Megatrends. This article contends that many changes in pharmacy practice are not incongruent with overall megatrends being experienced by our nation in general. Thus pharmacy practitioners and the profession must work diligently to ensure that both reflect social adjustments that lead to optimal results for patients. PMID:10106113

Hatoum, H T



The Promise of Cultural Studies of Education.  

ERIC Educational Resources Information Center

Cultural studies practice within education can potentially positively transform education. Those within the field must target broader audiences and translate their messages to those in most need. This paper describes cultural studies in education; develops five key themes of cultural studies, critically reviewing four cultural studies of education…

Hytten, Kathy



Promises and Pitfalls of Learning Objects  

ERIC Educational Resources Information Center

Learning objects (LOs), generally understood as digital learning resources shared through the Internet and reused in multiple learning contexts, have aroused worldwide enthusiasm in the field of educational technology during the last years. Although LOs and LO systems offer tremendous possibilities to improve educational practices, there are many…

Nurmi, Sami; Jaakkola, Tomi



Nanotechnology: Promises and challenges for tomorrow  

SciTech Connect

Nanotechnology is based on the ability to create and utilize materials, devices and systems through control of the matter at the nanometer scale. If successful, nanotechnology is expected to lead to broad new technological developments. The efficiency of energy conversion can be increased through the use of nanostructured materials with enhanced magnetic, light emission or wear resistant properties. Energy generation using nanostructured photovoltaics or nanocluster driven photocatalysis could fundamentally change the economic viability of renewable energy sources. In addition, the ability to imitate molecular processes found in living organisms may be key to developing highly sensitive and discriminating chemical and biological sensors. Such sensors could greatly expand the range of medical home testing as well as provide new technologies to counter the spread of chemical and biological weapons. Even the production of chemicals and materials could be revolutionized through the development of molecular reactors that can promote low energy chemical pathways for materials synthesis. Although nanotechnologies hold great promise, significant scientific challenges must be addressed before they can convert that promise into a reality. A key challenge in nanoscience is to understand how nano-scale tailoring of materials can lead to novel and enhanced functions. The authors' laboratory, for example, is currently making broad contributions in this area by synthesizing and exploring nanomaterials ranging from layered structures for electronics/photonics to novel nanocrystalline catalysts. They are even adapting functions from biological molecules to synthesize new forms of nanostructured materials.




Promises in intelligent plant control systems  

SciTech Connect

The control system is the brain of a power plant. The traditional goal of control systems has been productivity. However, in nuclear power plants the potential for disaster requires safety to be the dominant concern, and the worldwide political climate demands trustworthiness for nuclear power plants. To keep nuclear generation as a viable option for power in the future, trust is the essential critical goal which encompasses all others. In most of today's nuclear plants the control system is a hybrid of analog, digital, and human components that focuses on productivity and operates under the protective umbrella of an independent engineered safety system. Operation of the plant is complex, and frequent challenges to the safety system occur which impact on their trustworthiness. Advances in nuclear reactor design, computer sciences, and control theory, and in related technological areas such as electronics and communications as well as in data storage, retrieval, display, and analysis have opened a promise for control systems with more acceptable human brain-like capabilities to pursue the required goals. This paper elaborates on the promise of futuristic nuclear power plants with intelligent control systems and addresses design requirements and implementation approaches.

Otaduy, P.J.



Microalgae and biofuels: a promising partnership?  


Microalgae have much higher lipid yields than those of agricultural oleaginosous crops, and they do not compromise arable land. Despite this, current microalga-based processes suffer from several constraints pertaining to the biocatalyst and the bioreactor, which hamper technologically and economically feasible scale-up. Here, we briefly review recent active research and development efforts worldwide, and discuss the most relevant shortcomings of microalgal biofuels. This review goes one step further relative to related studies, because it tackles otherwise scarcely mentioned issues - for example, heterotrophic versus autotrophic metabolism, alkane versus glyceride synthesis, conduction versus bubbling of CO(2), and excretion versus accumulation of lipids. Besides promising solutions that have been hypothesized and arise from multidisciplinary approaches, we also consider less conventional ones. Microalgae and biofuels hold indeed a promising partnership, but a fully competitive technology is not expected to be available before the end of this decade, because the need for one order of magnitude increase in productivity requires development of novel apparatuses and transformed cells. PMID:21724282

Malcata, F Xavier



Strategies for Success: Promising Ideas in Adult College Completion. Policy Exchanges  

ERIC Educational Resources Information Center

This publication is the first of a series focusing on promising new ideas and innovative practices developed through the Adult College Completion Network. The brief addresses five topics of importance to those working to improve adult college completion: (1) Data availability particular to the returning adult population; (2) Partnerships between…

Lane, Patrick



The Impact of Advanced Curriculum on the Achievement of Mathematically Promising Elementary Students  

ERIC Educational Resources Information Center

The primary aim of Project M[superscript 3]: Mentoring Mathematical Minds was to develop and field test advanced units for mathematically promising elementary students based on exemplary practices in gifted and mathematics education. This article describes the development of the units and reports on mathematics achievement results for students in…

Gavin, M. Katherine; Casa, Tutita M.; Adelson, Jill L.; Carroll, Susan R.; Sheffield, Linda Jensen



The promising trajectory of autism therapeutics discovery.  


Pharmacological interventions for neurodevelopmental disorders are increasingly tractable. Autism is a neurodevelopmental disorder that affects approximately 1% of the population. Currently, the standard of care is early behavioral therapy. No approved medical treatments for the diagnostic symptoms are available. Strong evidence for genetic causes of autism implicates proteins that mediate synaptic transmission and structure. Mouse models with targeted mutations in these synaptic genes display behavioral symptoms relevant to the social communication abnormalities and repetitive behaviors that define autism spectrum disorder (ASD), along with biological abnormalities in synaptic physiology and morphology. As we discuss here, promising pharmacological targets, emerging from the mouse model studies, are now being pursued in early clinical trials. Thus, a high-prevalence disorder that was previously considered to be medically untreatable is now moving into the therapeutic arena. PMID:24362109

Silverman, Jill L; Crawley, Jacqueline N



Cobalt Derivatives as Promising Therapeutic Agents  

PubMed Central

Inorganic complexes are versatile platforms for the development of potent and selective pharmaceutical agents. Cobalt possesses a diverse array of properties that can be manipulated to yield promising drug candidates. Investigations into the mechanism of cobalt therapeutic agents can provide valuable insight into the physicochemical properties that can be harnessed for drug development. This review presents examples of bioactive cobalt complexes with special attention to their mechanisms of action. Specifically, cobalt complexes that elicit biological effects through protein inhibition, modification of drug activity, and bioreductive activation are discussed. Insights gained from these examples reveal features of cobalt that can be rationally tuned to produce therapeutics with high specificity and improved efficacy for the biomolecule or pathway of interest.

Heffern, Marie C.; Yamamoto, Natsuho; Holbrook, Robert J.; Eckermann, Amanda L.; Meade, Thomas J.



The promise and peril of healthcare forecasting.  


Health plans and physician groups increasingly use sophisticated tools to predict individual patient outcomes. Such analytics will accelerate as US medicine enters the digital age. Promising applications of forecasting include better targeting of disease management as well as innovative patient care approaches such as personalized health insurance and clinical decision support systems. In addition, stakeholders will use predictions to advance their organizational agendas, and unintended consequences could arise. Forecasting-based interventions might have uncertain effectiveness, focus on cost savings rather than long-term health, or specifically exclude disadvantaged populations. Policy makers, health plans, and method developers should adopt strategies that address these concerns in order to maximize the benefit of healthcare forecasting on the long-term health of patients. PMID:22435964

Wharam, J Frank; Weiner, Jonathan P



Diabetic macular edema: New promising therapies.  


The treatment of diabetic macular edema is rapidly evolving. The era of laser therapy is being quickly replaced by an era of pharmacotherapy. Several pharmacotherapies have been recently developed for the treatment of retinal vascular diseases such as diabetic macular edema. Several intravitreal injections or sustained delivery devices have undergone phase 3 testing while others are currently being evaluated. The results of clinical trials have shown the superiority of some of these agents to laser therapy. However, with the availability of several of these newer agents, it may be difficult to individualize treatment options especially those patients respond differently to various therapies. As such, more effort is still needed in order to determine the best treatment regimen for a given patient. In this article, we briefly summarize the major new therapeutic additions for the treatment of diabetic macular edema and allude to some future promising therapies. PMID:24379924

Shamsi, Hanan N Al; Masaud, Jluwi S; Ghazi, Nicola G



Review of Some Promising Fractional Physical Models  

NASA Astrophysics Data System (ADS)

Fractional dynamics is a field of study in physics and mechanics investigating the behavior of objects and systems that are characterized by power-law nonlocality, power-law long-term memory or fractal properties by using integrations and differentiation of non-integer orders, i.e., by methods in the fractional calculus. This paper is a review of physical models that look very promising for future development of fractional dynamics. We suggest a short introduction to fractional calculus as a theory of integration and differentiation of noninteger order. Some applications of integro-differentiations of fractional orders in physics are discussed. Models of discrete systems with memory, lattice with long-range inter-particle interaction, dynamics of fractal media are presented. Quantum analogs of fractional derivatives and model of open nano-system systems with memory are also discussed.

Tarasov, Vasily E.



Liver support systems: promise and reality.  


Effective liver support is needed for a variety of indications. A large number of both biological (containing hepatocytes) and non-biological extracorporeal liver support systems have been described in the literature over the last 50 years. Despite this, there is a paucity of good quality randomized control data examining the effectiveness of these therapies in human liver failure. In this review article, we examine the available data, with particular emphasis on the current front runners, the MARS and HepatAssist systems. Other problems associated with the development of these liver support systems are also discussed. Although promising in animal studies, we conclude that the use of these technologies is not supported currently by a sufficient evidence base to recommend them for routine clinical use and that a lack of understanding about the critical functions required of a liver support system is retarding a more rational approach to the design of these systems. PMID:16336437

Wigg, Alan J; Padbury, Robert T



Background, Principles and Promise of Nanodielectrics  

Microsoft Academic Search

\\u000a Electrical insulation based on nanodielectric technology stems from the use of fillers in polymeric materials which has been\\u000a common practice since polymer insulation was first introduced. However, when the filler size is reduced to nanometric size,\\u000a the internal interface becomes dominant and unique properties can be obtained. The basic processes and effects are introduced\\u000a in order to provide background and

J. Keith Nelson


Kairos and practice wisdom in social work practice  

Microsoft Academic Search

Practice wisdom is a form of practical moral reasoning when social workers face the complexity and uncertainty encountered in practice. Following a literature review on practice wisdom in social work, its essential features are discussed, identifying a neglected element in the literature—the element of time. The element of time is found to be implicitly considered in models of social work

Nai Ming Tsang



E-cigarettes: promise or peril?  


Electronic cigarettes (e-cigarettes) use a heating element to vaporize nicotine and other ingredients, simulating the visual, sensory, and behavioral aspects of smoking without the combustion of tobacco. An ever-growing number of companies around the world manufacture a wide variety of e-cigarette brands, despite scant information on the safety of the ingredients for human inhalation. This article provides an overview of the history, production, and marketing of e-cigarettes, the contents of e-cigarettes and vapor, how they are used, public health concerns, and implications for nursing practice, research, and policy development. PMID:22289406

Riker, Carol A; Lee, Kiyoung; Darville, Audrey; Hahn, Ellen J



Bringing Promise to Washington, DC. The DC Promise Neighborhood Initiative. Program on Neighborhoods and Youth Development  

ERIC Educational Resources Information Center

The U.S. Department of Education's Promise Neighborhood Initiative (DCPNI) is one of the Obama administration's major antipoverty initiatives and a core strategy of the White House's Neighborhood Revitalization Initiative. It is intended to improve educational outcomes by creating a continuum of school readiness, academic services, and family and…

Comey, Jennifer; Scott, Molly M.; Popkin, Susan J.; Falkenburger, Elsa



Fulfilling The Pittsburgh Promise[R]: Early Progress of Pittsburgh's Postsecondary Scholarship Program. Monograph  

ERIC Educational Resources Information Center

This report presents a detailed assessment of the extent to which "The Pittsburgh Promise"--a postsecondary education scholarship intended to remedy the area's population decline, foster high school completion and college readiness among Pittsburgh district students, and prepare a capable and energetic workforce for the city--has met its goals to…

Gonzalez, Gabriella C.; Bozick, Robert; Tharp-Taylor, Shannah; Phillips, Andrea



Furfural--a promising platform for lignocellulosic biofuels.  


Furfural offers a promising, rich platform for lignocellulosic biofuels. These include methylfuran and methyltetrahydrofuran, valerate esters, ethylfurfuryl and ethyltetrahydrofurfuryl ethers as well as various C(10)-C(15) coupling products. The various production routes are critically reviewed, and the needs for improvements are identified. Their relative industrial potential is analysed by defining an investment index and CO(2) emissions as well as determining the fuel properties for the resulting products. Finally, the most promising candidate, 2-methylfuran, was subjected to a road trial of 90,000 km in a gasoline blend. Importantly, the potential of the furfural platform relies heavily on the cost-competitive production of furfural from lignocellulosic feedstock. Conventional standalone and emerging coproduct processes-for example, as a coproduct of cellulosic ethanol, levulinic acid or hydroxymethyl furfural-are expensive and energetically demanding. Challenges and areas that need improvement are highlighted. In addition to providing a critical review of the literature, this paper also presents new results and analysis in this area. PMID:22213717

Lange, Jean-Paul; van der Heide, Evert; van Buijtenen, Jeroen; Price, Richard



Promises of advanced technology realized at Martin  

SciTech Connect

The 2,488-MW Martin station is a gas/oil-fired facility that embodies today`s demand for flexible operations, technological advances, and reduced production costs. Martin station first rose up from the Everglades in the early 1980s, with the construction of two 814-MW oil-fired steam plants, Units 1 and 2. Natural-gas-firing capability was added to the balanced-draft, natural-circulation boilers in 1986, increasing the station`s fuel flexibility. Martin then leaped into the headlines in the early 1990s when it added combined-cycle (CC) Units 3 and 4. With this 860-MW expansion, FP and L boldly became the fleet leader for the advanced, 2350F-class 7FA gas turbines. Further pushing he technology envelope, the CC includes a three-pressure reheat steam system that raises net plant efficiency for Units 3 and 4 to 54%, on a lower-heating-value (LHV) basis. Incorporating the reheat cycle required significant redesign of the gas-turbine/heat-recovery steam generator (HRSG) train, in order to maintain a rapid startup capability without exceeding metallurgical limits. Perhaps even more important than the technological achievements, Martin stands out from the crowd for its people power, which ensured that the promises of advanced technology actually came to fruition. This station`s aggressive, empowered O and M team shows that you can pioneer technology, reduce operating costs, and deliver high availability--all at the same time.

Swanekamp, R.



GEOTEC-a promising energy alternative  

SciTech Connect

Geothermal reconnaissance has shown a promising resource at the base of three clustered volcanoes on Adak Island, located along the Aleutian arc of Alaska. Geophysical surveys revealed areas of abrupt and steep gravitational gradients and high electrical conductivity over the volcanoes, indicating possible subsurface magma. Geochemical analyses indicated a potential reservoir temperature of 180/sup 0/C. The nearby Bering Sea has a surface temperature ranging between 3/sup 0/ and 8/sup 0/C year-round and would provide for high heat reinjection. The combination of geothermal and ocean sink resources could result in a GEOTEC plant having an overall thermal efficiency approaching one-third that of the present diesel-electric generating system at the Naval Air Station on Adak. The more than 5000 permanently stationed personnel at the station consume over 8 million gal of JP-5 fuel for space heating and electrical power. Presently, electric energy on Adak costs 250-350 mils/kilowatt-hour. Preliminary estimates of the cost of electric power from a GEOTEC plant are about 200 mils/kilowatt-hour. A GEOTEC plant would also be a secure alternative energy source for the US Navy.

Gerrard, C.S.; Gelb, G.H.; Lowrie, A.



Flight-deck automation: Promises and problems  

NASA Technical Reports Server (NTRS)

The state of the art in human factors in flight-deck automation is presented. A number of critical problem areas are identified and broad design guidelines are offered. Automation-related aircraft accidents and incidents are discussed as examples of human factors problems in automated flight.

Wiener, E. L.; Curry, R. E.



Parkinson's Disease: Challenges, Progress, and Promise.  

National Technical Information Service (NTIS)

Ever since PD was first described in 1817, scientists have pursued the causes and treatment of the disease. In the early 1960s, scientists identified the primary problem underlying the disease: the loss of brain cells that produce a chemical called dopami...



XIAP: Apoptotic brake and promising therapeutic target  

Microsoft Academic Search

The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the newly discovered family of intrinsic inhibitors of apoptosis (IAP) proteins. IAPs block cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. Although other proteins have been identified which inhibit upstream caspases, only the IAPs have been demonstrated to be endogenous repressors of

Martin Holcik; Hilary Gibson; Robert G. Korneluk



Polyfluoroalkoxyphosphazenes — a Promising Class of Organoelemental Polymers  

NASA Astrophysics Data System (ADS)

The results of the synthesis of polyfluoroalkoxyphosphazenes and also polyorganophosphazenes containing various non-fluorinated organic groups as substituents at the phosphorus atoms together with fluoroalkoxy-groups are surveyed. The characteristics of the formation of these polymers by the chemical modification of polydichlorophosphazene are examined. A systematic account is given of the literature data on the properties of polyfluoroalkoxyphosphazenes and their practical applications. The ways in which varieties of the macromolecules of these polymers arise and the influence of the nature and number of anomalous units on their properties are considered. Attention is drawn to a fundamentally important characteristic feature of polyfluoroalkoxyphosphazenes, namely the high sensitivity of their properties to anomalous units when the content of the latter is less than 1 mole %. The bibliography includes 179 references.

Vinogradova, Svetlana V.; Tur, Dzidra R.; Minosyants, I. I.



Alcoholism research: delivering on the promise.  


Prospects for research advances in alcoholism are very promising, because of the explosion in the neurosciences and advances in epidemiology and typology of the disorder. For example, the field is now ready for molecular genetics studies of the early onset form of alcoholism that is transmitted from father to son with high penetrance. Leading neuroscientists are being recruited into alcoholism research. Paradoxically, this time of new hope coincides with challenges to the scientific enterprise, such as the animal rights movement and impatience with the scientific process in the face of the public health emergencies represented by acquired immunodeficiency syndrome (AIDS) and drug abuse. The emergence of genetically based subtypes of alcoholism suggests that at least two discrete illness processes are involved. Mounting evidence from spinal fluid studies has rekindled interest in a key role for serotonin in the early onset form of alcoholism. One hypothesis now being explored is that genetically low brain serotonin function may be part of the predisposition to this form of alcoholism. It is known that acute alcohol intake transiently increases brain serotonin turnover. Thus, drinking might be viewed as an attempt to correct a deficit, only to produce further serotonin depletion as the drug's effect wears off, setting up a vicious cycle of repeated attempts to self-medicate. Impulsive, violent, and suicidal behavior as well as alcohol abuse are associated with the low brain serotonin activity. Persons with these problems suffer from circadian rhythm and glucose metabolism disturbances that may also be mediated by serotonin. New pharmacological probes are now available to tease out the mechanisms of altered serotonin function. The progressively deteriorating course of severe episodic alcoholism in many ways parallels the process of electrically kindled seizures in experimental animals. There is evidence that repeated withdrawal episodes may kindle a worsening course, including phobic disorders, perhaps by triggering a hyper-reactive noradrenalin system. PMID:2847208

Goodwin, F K



Alcoholism research: delivering on the promise.  

PubMed Central

Prospects for research advances in alcoholism are very promising, because of the explosion in the neurosciences and advances in epidemiology and typology of the disorder. For example, the field is now ready for molecular genetics studies of the early onset form of alcoholism that is transmitted from father to son with high penetrance. Leading neuroscientists are being recruited into alcoholism research. Paradoxically, this time of new hope coincides with challenges to the scientific enterprise, such as the animal rights movement and impatience with the scientific process in the face of the public health emergencies represented by acquired immunodeficiency syndrome (AIDS) and drug abuse. The emergence of genetically based subtypes of alcoholism suggests that at least two discrete illness processes are involved. Mounting evidence from spinal fluid studies has rekindled interest in a key role for serotonin in the early onset form of alcoholism. One hypothesis now being explored is that genetically low brain serotonin function may be part of the predisposition to this form of alcoholism. It is known that acute alcohol intake transiently increases brain serotonin turnover. Thus, drinking might be viewed as an attempt to correct a deficit, only to produce further serotonin depletion as the drug's effect wears off, setting up a vicious cycle of repeated attempts to self-medicate. Impulsive, violent, and suicidal behavior as well as alcohol abuse are associated with the low brain serotonin activity. Persons with these problems suffer from circadian rhythm and glucose metabolism disturbances that may also be mediated by serotonin. New pharmacological probes are now available to tease out the mechanisms of altered serotonin function.(ABSTRACT TRUNCATED AT 250 WORDS)

Goodwin, F K



Materializing research promises: opportunities, priorities and conflicts in translational medicine  

PubMed Central

There is considerable evidence that the translation rate of major basic science promises to clinical applications has been inefficient and disappointing. The deficiencies of translational science have often been proposed as an explanation for this failure. An alternative explanation is that until recently basic science advances have made oversimplified assumptions that have not matched the true etiological complexity of most common diseases; while clinical science has suffered from poor research practices, overt biases and conflicts of interest. The advent of molecular medicine and the recasting of clinical science along the principles of evidence-based medicine provide a better environment where translational research may now materialize its goals. At the same time, priority issues need to be addressed in order to exploit the new opportunities. Translational research should focus on diseases with global impact, if true progress is to be made against human suffering. The health outcomes of interest for translational efforts need to be carefully defined and a balance must be struck between the subjective needs of healthcare consumers and objective health outcomes. Development of more simple, practical and safer interventions may be as important a target for translational research as the development of cures for diseases where no effective interventions are available at all. Moreover, while the role of the industry is catalytic in translating research advances to licensed interventions, academic independence needs to be sustained and strengthened at a global level. Conflicts of interest may stifle translational research efforts internationally. The profit motive is unlikely to be sufficient alone to advance biomedical research towards genuine progress.

Ioannidis, John PA



The democratization of finance? Promises, outcomes and conditions  

Microsoft Academic Search

This paper analyses the ‘democratization of finance’ or the promise that all households can make money and\\/or manage risk by buying appropriate financial services products. It does so by exploring the reasons for discrepancy between what is promised and what can be delivered. Our analysis starts from the economic promises and political pitches for the democratization of finance since the

Ismail Erturk; Julie Froud; Sukhdev Johal; Adam Leaver; Karel Williams



Promised Reward and Creativity: Effects of Prior Experience  

Microsoft Academic Search

An experiment involving 283 preadolescent schoolchildren investigated how divergent-thinking training affected subsequent creativity for promised reward in a new task administered by a different individual. The promise of reward for picture drawing increased creativity if children had previously generated novel uses for physical objects with or without reward. In contrast, the promise of reward did not increase the creativity of

Robert Eisenberger; Frances Haskins; Paul Gambleton



Homogeneous Immunoassays: Historical Perspective and Future Promise  

NASA Astrophysics Data System (ADS)

The founding and growth of Syva Company is examined in the context of its leadership role in the development of homogeneous immunoassays. The simple mix and read protocols of these methods offer advantages in routine analytical and clinical applications. Early homogeneous methods were based on insensitive detection of immunoprecipitation during antigen/antibody binding. The advent of reporter groups in biology provided a means of quantitating immunochemical binding by labeling antibody or antigen and physically separating label incorporated into immune complexes from free label. Although high sensitivity was achieved, quantitative separations were experimentally demanding. Only when it became apparent that reporter groups could provide information, not only about the location of a molecule but also about its microscopic environment, was it possible to design practical non-separation methods. The evolution of early homogenous immunoassays was driven largely by the development of improved detection strategies. The first commercial spin immunoassays, developed by Syva for drug abuse testing during the Vietnam war, were followed by increasingly powerful methods such as immunochemical modulation of enzyme activity, fluorescence, and photo-induced chemiluminescence. Homogeneous methods that quantify analytes at femtomolar concentrations within a few minutes now offer important new opportunities in clinical diagnostics, nucleic acid detection and drug discovery.

Ullman, Edwin F.



Multivariate meta-analysis: Potential and promise  

PubMed Central

The multivariate random effects model is a generalization of the standard univariate model. Multivariate meta-analysis is becoming more commonly used and the techniques and related computer software, although continually under development, are now in place. In order to raise awareness of the multivariate methods, and discuss their advantages and disadvantages, we organized a one day ‘Multivariate meta-analysis’ event at the Royal Statistical Society. In addition to disseminating the most recent developments, we also received an abundance of comments, concerns, insights, critiques and encouragement. This article provides a balanced account of the day's discourse. By giving others the opportunity to respond to our assessment, we hope to ensure that the various view points and opinions are aired before multivariate meta-analysis simply becomes another widely used de facto method without any proper consideration of it by the medical statistics community. We describe the areas of application that multivariate meta-analysis has found, the methods available, the difficulties typically encountered and the arguments for and against the multivariate methods, using four representative but contrasting examples. We conclude that the multivariate methods can be useful, and in particular can provide estimates with better statistical properties, but also that these benefits come at the price of making more assumptions which do not result in better inference in every case. Although there is evidence that multivariate meta-analysis has considerable potential, it must be even more carefully applied than its univariate counterpart in practice. Copyright © 2011 John Wiley & Sons, Ltd.

Jackson, Dan; Riley, Richard; White, Ian R



Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls.  


The integration of research on neuroimaging and pharmacogenetics holds promise for improving treatment for neuropsychiatric conditions. Neuroimaging may provide a more sensitive early measure of treatment response in genetically defined patient groups, and could facilitate development of novel therapies based on an improved understanding of pathogenic mechanisms underlying pharmacogenetic associations. This review summarizes progress in efforts to incorporate neuroimaging into genetics and treatment research on major psychiatric disorders, such as schizophrenia, major depressive disorder, bipolar disorder, attention-deficit/hyperactivity disorder, and addiction. Methodological challenges include: performing genetic analyses in small study populations used in imaging studies; inclusion of patients with psychiatric comorbidities; and the extensive variability across studies in neuroimaging protocols, neurobehavioral task probes, and analytic strategies. Moreover, few studies use pharmacogenetic designs that permit testing of genotype × drug effects. As a result of these limitations, few findings have been fully replicated. Future studies that pre-screen participants for genetic variants selected a priori based on drug metabolism and targets have the greatest potential to advance the science and practice of psychiatric treatment. PMID:23793356

Falcone, Mary; Smith, Ryan M; Chenoweth, Meghan J; Kumar Bhattacharjee, Abesh; Kelsoe, John R; Tyndale, Rachel F; Lerman, Caryn



The promise--and peril--of integrated cost systems.  


Recent advances in managerial accounting have helped executives get the information they need to make good strategic decisions. But today's enterprise resource planning systems promise even greater benefits--the chance to integrate activity-based costing, operational-control, and financial reporting systems. But managers need to approach integration very thoughtfully, or they could end up with a system that drives decision making in the wrong direction. Operational-control and ABC systems have fundamentally different purposes. Their requirements for accuracy, timeliness, and aggregation are so different that no single, fully integrated approach can be adequate for both purposes. If an integrated system used real-time cost data instead of standard rates in its ABC subsystem, for example, the result would be dangerously distorted messages about individual product profitability--and that's precisely the problem ABC systems were originally designed to address. Proper linkage and feedback between the two systems is possible, however. Through activity-based budgeting, the ABC system is linked directly to operations control: managers can determine the supply and practical capacity of resources in forthcoming periods. Linking operational control to ABC is also possible. The activity-based portion of an operational control system collects information that, while it mustn't be fed directly into the activity-based strategic cost system, can be extremely useful once it's been properly analyzed. Finally, ABC and operational control can be linked to financial reporting to generate cost of goods sold and inventory valuations--but again, with precautions. PMID:10181585

Cooper, R; Kaplan, R S



Smaller sulfur molecules promise better lithium-sulfur batteries.  


The lithium-sulfur battery holds a high theoretical energy density, 4-5 times that of today's lithium-ion batteries, yet its applications have been hindered by poor electronic conductivity of the sulfur cathode and, most importantly, the rapid fading of its capacity due to the formation of soluble polysulfide intermediates (Li(2)S(n), n = 4-8). Despite numerous efforts concerning this issue, combatting sulfur loss remains one of the greatest challenges. Here we show that this problem can be effectively diminished by controlling the sulfur as smaller allotropes. Metastable small sulfur molecules of S(2-4) were synthesized in the confined space of a conductive microporous carbon matrix. The confined S(2-4) as a new cathode material can totally avoid the unfavorable transition between the commonly used large S(8) and S(4)(2-). Li-S batteries based on this concept exhibit unprecedented electrochemical behavior with high specific capacity, good cycling stability, and superior rate capability, which promise a practicable battery with high energy density for applications in portable electronics, electric vehicles, and large-scale energy storage systems. PMID:23101502

Xin, Sen; Gu, Lin; Zhao, Na-Hong; Yin, Ya-Xia; Zhou, Long-Jie; Guo, Yu-Guo; Wan, Li-Jun



Promising avenues of therapeutics for bipolar illness  

PubMed Central

Basic scientific advances in understanding the neuropsychobioloqy of bipolar disorder have given us a multitude of opportunities to explore and exploit new avenues of therapeutics. Pharmacotherapeutic approaches include: neuropeptides (agonists such as thyrotropin-releasing hormone and antagonists such as corticotropin-releasing hormone), neurotrophic factors (especially brain-derived neurotrophic factor), and glutamatergic mechanisms (such as riluzole, ketamine, and antagonists of the NR-2B subunit of the glutamate receptor). Physiological interventions that would offer alternatives to electroconvulsive therapy include: repeated transcranial magnetic stimulation, especially at more intense stimulation parameters; magnetic stimulation therapy (seizures induced more focally by magnetic rather than electrical stimulation with resulting reduced meaning loss); vagal nerve stimulation, and deep brain stimulation. However, these, as well as the panoply of existing treatments, require further intensive investigation to place each of them in the proper therapeutic seguence and combination for the individual patient, based on development of better clinical and biological predictors of response. Large clinical trial networks and development of systematic research in clinical practice settings, such as that featured by the National Cancer institute for cancer chemotherapy, would greatly accelerate the progress in incorporating new, as well as existing, agents into the best treatment strategies. The bipolar disorders, which are increasingly recognized as complex, highly comorbid conditions with a high morbidity and mortality, of which the majority start in childhood and adolescence, are not likely to respond completely to any single new treatment agent, and new public health initiatives and research strategies are needed as much as any new single treatment advance.

Post, Robert M.



Phenanthroindolizidines and Phenanthroquinolizidines: Promising Alkaloids for Anti-Cancer Therapy  

PubMed Central

The phenanthroindolizidine and phenanthroquinolizidine alkaloids, typified by tylophorine and cryptopleurine, are a family of plant-derived small molecules with significant therapeutic potential. The plant extracts have been used in herbal medicine and the isolated compounds have displayed a range of promising therapeutic activity such as anti-ameobicidal, anti-viral, anti-inflammatory and anti-cancer activity. Despite their therapeutic protential, no compounds in this class have fully passed clinical trials. Drawbacks include low in vivo anti-cancer activity, central nervous system toxicity and low natural availability. A number of biological effects of these compounds, such as protein and nucleic acid synthesis suppression, have been identified, but the specific biomolecular targets have not yet been identified. Significant effort has been expended in the synthesis and structure-activity-relationship (SAR) studies of these compounds with the hope that a new drug will emerge. This review will highlight important contributions to the isolation, synthesis, SAR and mechanism of action of the phenanthroindolizidine and pheanthroquinolizidine alkaloids.

Chemler, Sherry R.



Vernonia condensata Baker (Asteraceae): a promising source of antioxidants.  


The present study evaluated the antioxidant potential of Vernonia condensata Baker (Asteraceae). Dried and powdered leaves were exhaustively extracted with ethanol by static maceration followed by partition to obtain the hexane, dichloromethane, ethyl acetate, and butanol fractions. Total phenols and flavonoids contents were determined through spectrophotometry and flavonoids were identified by HPLC-DAD system. The antioxidant activity was assessed by DPPH radical scavenging activity, TLC-bioautography, reducing power of Fe(+3), phosphomolybdenum, and TBA assays. The total phenolic content and total flavonoids ranged from 0.19 to 23.11?g/100?g and from 0.13 to 4.10 g/100?g, respectively. The flavonoids apigenin and luteolin were identified in the ethyl acetate fraction. The IC50 of DPPH assay varied from 4.28 to 75.10?µg/mL and TLC-bioautography detected the antioxidant compounds. The reducing power of Fe(+3) was 19.98 to 336.48? ?g/mL, while the reaction with phosphomolybdenum ranged from 13.54% to 32.63% and 56.02% to 135.00% considering ascorbic acid and rutin as reference, respectively. At 30?mg/mL, the ethanolic extract and fractions revealed significant effect against lipid peroxidation. All these data sustain that V. condensata is an important and promising source of bioactive substances with antioxidant activity. PMID:24489987

da Silva, Jucélia Barbosa; Temponi, Vanessa dos Santos; Gasparetto, Carolina Miranda; Fabri, Rodrigo Luiz; Aragão, Danielle Maria de Oliveira; Pinto, Nícolas de Castro Campos; Ribeiro, Antônia; Scio, Elita; Del-Vechio-Vieira, Glauciemar; de Sousa, Orlando Vieira; Alves, Maria Silvana



Using association rule mining to determine promising secondary phenotyping hypotheses  

PubMed Central

Motivation: Large-scale phenotyping projects such as the Sanger Mouse Genetics project are ongoing efforts to help identify the influences of genes and their modification on phenotypes. Gene–phenotype relations are crucial to the improvement of our understanding of human heritable diseases as well as the development of drugs. However, given that there are ?20 000 genes in higher vertebrate genomes and the experimental verification of gene–phenotype relations requires a lot of resources, methods are needed that determine good candidates for testing. Results: In this study, we applied an association rule mining approach to the identification of promising secondary phenotype candidates. The predictions rely on a large gene–phenotype annotation set that is used to find occurrence patterns of phenotypes. Applying an association rule mining approach, we could identify 1967 secondary phenotype hypotheses that cover 244 genes and 136 phenotypes. Using two automated and one manual evaluation strategies, we demonstrate that the secondary phenotype candidates possess biological relevance to the genes they are predicted for. From the results we conclude that the predicted secondary phenotypes constitute good candidates to be experimentally tested and confirmed. Availability: The secondary phenotype candidates can be browsed through at Contact: or Supplementary information: Supplementary data are available at Bioinformatics online.

Oellrich, Anika; Smedley, Damian



Relationship of osteopathic medical licensure examinations with undergraduate admission measures and predictive value of identifying future performance in osteopathic principles and practice/osteopathic manipulative medicine courses and rotations.  


Two hundred sixty-five students from four classes at one school of osteopathic medicine were studied to determine the correlation between several frequently used premedical admission criteria to predict performance on the early and current versions of the osteopathic medical licensure examinations. Further analysis evaluated the predictive value of the examination of the National Board of Osteopathic Medical Examiners (NBOME) and its successor, the Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) in determining subsequent performance in the ascending levels of the examination sequence, as well as to predict performance in the courses and rotations of osteopathic principles and practice (OPP) and osteopathic manipulative medicine (OMM). This study also investigated the relationship between the early and later parts of the osteopathic medical licensure examinations. Analysis showed that of all premedical parameters, only the Medical College Aptitude Test score was positively correlated with performance on COMLEX-USA. In addition, a positive correlation was demonstrated between the performance in either Level 1 of COMLEX-USA or in the earlier form of the NBOME examination Part I and subsequent performance on the current Level 2 of COMLEX-USA or the old NBOME Part II. Finally, analysis indicated that COMLEX-USA predicted performance in OPP knowledge and skills. PMID:12462306

Meoli, Frederick G; Wallace, Warren S; Kaiser-Smith, Joanne; Shen, Linjun



Uneasy promises: sexuality, health, and human rights.  


Although attention to the links between health and human rights is growing globally, the full potential of a progressive human rights approach to health has not yet been explored, and it is even more faintly understood in the United States than in the rest of the world. At the same time, global claims for sexual rights, particularly for those identifying as gay, lesbian, transsexual, or bisexual, are increasingly being made as human rights claims. All of these approaches to rights advocacy risk limiting their own transformative impact unless advocates critique their own strategies. Paradoxically, using health as a way to bring attention to nonheteronormative sexualities can be both helpful and potentially dangerous, especially when coupled with human rights. Recognizing sexuality as a critical element of humanity, and establishing a fundamental human right to health, can play a role in broader social justice claims, but the tendency of both public health and human rights advocacy to "normalize" and regulate must be scrutinized and challenged. PMID:11392922

Miller, A M



Resistant starch: promise for improving human health.  


Ongoing research to develop digestion-resistant starch for human health promotion integrates the disciplines of starch chemistry, agronomy, analytical chemistry, food science, nutrition, pathology, and microbiology. The objectives of this research include identifying components of starch structure that confer digestion resistance, developing novel plants and starches, and modifying foods to incorporate these starches. Furthermore, recent and ongoing studies address the impact of digestion-resistant starches on the prevention and control of chronic human diseases, including diabetes, colon cancer, and obesity. This review provides a transdisciplinary overview of this field, including a description of types of resistant starches; factors in plants that affect digestion resistance; methods for starch analysis; challenges in developing food products with resistant starches; mammalian intestinal and gut bacterial metabolism; potential effects on gut microbiota; and impacts and mechanisms for the prevention and control of colon cancer, diabetes, and obesity. Although this has been an active area of research and considerable progress has been made, many questions regarding how to best use digestion-resistant starches in human diets for disease prevention must be answered before the full potential of resistant starches can be realized. PMID:24228189

Birt, Diane F; Boylston, Terri; Hendrich, Suzanne; Jane, Jay-Lin; Hollis, James; Li, Li; McClelland, John; Moore, Samuel; Phillips, Gregory J; Rowling, Matthew; Schalinske, Kevin; Scott, M Paul; Whitley, Elizabeth M



Flight deck automation: Promises and realities  

NASA Technical Reports Server (NTRS)

Issues of flight deck automation are multifaceted and complex. The rapid introduction of advanced computer-based technology onto the flight deck of transport category aircraft has had considerable impact both on aircraft operations and on the flight crew. As part of NASA's responsibility to facilitate an active exchange of ideas and information among members of the aviation community, a NASA/FAA/Industry workshop devoted to flight deck automation, organized by the Aerospace Human Factors Research Division of NASA Ames Research Center. Participants were invited from industry and from government organizations responsible for design, certification, operation, and accident investigation of transport category, automated aircraft. The goal of the workshop was to clarify the implications of automation, both positive and negative. Workshop panels and working groups identified issues regarding the design, training, and procedural aspects of flight deck automation, as well as the crew's ability to interact and perform effectively with the new technology. The proceedings include the invited papers and the panel and working group reports, as well as the summary and conclusions of the conference.

Norman, Susan D. (editor); Orlady, Harry W. (editor)



Ethnography in community psychology: promises and tensions.  


Community psychology recognizes the need for research methods that illuminate context, culture, diversity, and process. One such method, ethnography, has crossed into multiple disciplines from anthropology, and indeed, community psychologists are becoming community ethnographers. Ethnographic work stands at the intersection of bridging universal questions with the particularities of people and groups bounded in time, geographic location, and social location. Ethnography is thus historical and deeply contextual, enabling a rich, in-depth understanding of communities that is aligned with the values and goals of community psychology. The purpose of this paper is to elucidate the potential of ethnography for community psychology and to encourage its use within the field as a method to capture culture and context, to document process, and to reveal how social change and action occur within and through communities. We discuss the method of ethnography, draw connections to community psychology values and goals, and identify tensions from our experiences doing ethnography. Overall, we assert that ethnography is a method that resonates with community psychology and present this paper as a resource for those interested in using this method in their research or community activism. PMID:24733402

Case, Andrew D; Todd, Nathan R; Kral, Michael J



Mexican Immigrant Youth and Resiliency: Research and Promising Programs. ERIC Digest.  

ERIC Educational Resources Information Center

Mexican immigrant youth lag behind other immigrant groups in educational completion and achievement, but many resilient Mexican immigrant youth have overcome tough odds to succeed. This digest examines the research about resiliency and some promising programs for Mexican American youth. Resiliency theory identifies protective factors present in…

Chavkin, Nancy Feyl; Gonzalez, John


Serological markers in psoriatic arthritis: promising tools.  


The aim of this study was to identify specific biomarkers that could be used to screen for psoriatic arthritis (PsA), as well as to assess disease activity and treatment outcome in affected patients. Forty-three outpatients considered eligible for anti-TNF-? treatment (etanercept 50?mg/week) were enrolled. Serum samples of vascular endothelial growth factor (VEGF), metalloproteinase-3 (MMP3), pentraxin 3 (PTX3), and high-sensitive C-reactive protein (hs-CRP) were collected at baseline (t0) and after 6 (t6), 12 (t12), and 24 months (t24) of treatment. Baseline values were compared with those of a group of healthy controls matched for age and sex. Disease activity scores and functional tests (DAS28, BASDAI, PASI, BASFI, HAQ, VAS pain, and VAS patient global disease activity) after treatment were found to be significantly different from baseline values. At baseline, MMP3, hs-CRP and VEGF values in the PsA-patients were found to be significantly higher with respect to levels in the controls. There were no differences in the PTX3 values. MMP3 was significantly lower at t6 (P?

Ramonda, Roberta; Modesti, Valentina; Ortolan, Augusta; Scanu, Anna; Bassi, Nicola; Oliviero, Francesca; Punzi, Leonardo



Identity Management Systems in Healthcare: The Issue of Patient Identifiers  

NASA Astrophysics Data System (ADS)

According to a recent recommendation of the European Commission, now is the time for Europe to enhance interoperability in eHealth. Although interoperability of patient identifiers seems promising for matters of patient mobility, patient empowerment and effective access to care, we see that today there is indeed a considerable lack of interoperability in the field of patient identification. Looking from a socio-technical rather than a merely technical point of view, one can understand the fact that the development and implementation of an identity management system in a specific healthcare context is influenced by particular social practices, affected by socio-economical history and the political climate and regulated by specific data protection legislations. Consequently, the process of making patient identification in Europe more interoperable is a development beyond semantic and syntactic levels. In this paper, we gives some examples of today’s patient identifier systems in Europe, discuss the issue of interoperability of (unique) patient identifiers from a socio-technical point of view and try not to ignore the ‘privacy side’ of the story.

Soenens, Els


Polymer Electrolytes:. Problems, Prospects, and Promises  

NASA Astrophysics Data System (ADS)

In 1975 P. V. Wright observed ionic conduction at elevated temperatures in polyethylene oxide (PEO) thin film electrolyte containing sodium salt. This seminal research generated wide spread interest in all-solid-state rechargeable lithium batteries. Armand took the cue from this observation and demonstrated the use of PEO/salt complex as electrolyte in lithium batteries. Soon after this a number of researchers have followed suit and studied the physical, electrical and transport properties of thin film PEO electrolyte. These studies have clearly identified the limitations of the PEO electrolyte. Chief among the limitations are a low cation transport number (t+), high glass transition temperature (Tg), and segmental motion of the polymer chain, which carries the cation through the bulk electrolyte. While low t+ leads to cell polarization and increase in cell resistance high Tg reduces conductivity at and around room temperature. For example, the conductivity of PEO electrolyte containing lithium salt is ~10-8 S/cm at room temperature. Attempts have been made to reduce Tg of PEO polymer by attaching PEO macromolecules to polyphosphazene (N=P) inorganic backbone, which is very flexible. Another material that has been investigated as a backbone material consists of Si-O chain. These two polymers exhibit a lower Tg and higher room temperature conductivity than the unmodified PEO. For example, the room temperature conductivity of the two polymers is around 10-5 S/cm - a 3 orders of magnitude increase in conductivity compared to unmodified PEO at around room temperature. Although this approach has yielded polymers with lower Tg, the t+ is still very low - ~0.25 - for lithium ion. Nano-ceramic particles of Al2O3, TiO2 etc. mechanically mixed with PEO electrolyte seem to increase t+. This approach also has inherent limitations regarding phase separation. The latest approach appears to involve integrating nano domains of inorganic moieties such as Si-O as part of the polymer chain. This approach not only has yielded an organic-inorganic polymer electrolyte with higher conductivity but appears to increase the t+ as well. An overview of the evolution of the all-solid-state polymer electrolyte in the last 25 years will be presented. This article addresses mainly the electrical and electrochemical properties and doesn't discuss the physicochemical and spectroscopic properties of dry polymer electrolytes.

Nagasubramanian, G.; Doughty, D. H.



Identifying tier one key suppliers.  


In today's global marketplace, businesses are becoming increasingly reliant on suppliers for the provision of key processes, activities, products and services in support of their strategic business goals. The result is that now, more than ever, the failure of a key supplier has potential to damage reputation, productivity, compliance and financial performance seriously. Yet despite this, there is no recognised standard or guidance for identifying a tier one key supplier base and, up to now, there has been little or no research on how to do so effectively. This paper outlines the key findings of a BCI-sponsored research project to investigate good practice in identifying tier one key suppliers, and suggests a scalable framework process model and risk matrix tool to help businesses effectively identify their tier one key supplier base. PMID:23615061

Wicks, Steve



Exploring the promises of intersectionality for advancing women's health research  

PubMed Central

Women's health research strives to make change. It seeks to produce knowledge that promotes action on the variety of factors that affect women's lives and their health. As part of this general movement, important strides have been made to raise awareness of the health effects of sex and gender. The resultant base of knowledge has been used to inform health research, policy, and practice. Increasingly, however, the need to pay better attention to the inequities among women that are caused by racism, colonialism, ethnocentrism, heterosexism, and able-bodism, is confronting feminist health researchers and activists. Researchers are seeking new conceptual frameworks that can transform the design of research to produce knowledge that captures how systems of discrimination or subordination overlap and "articulate" with one another. An emerging paradigm for women's health research is intersectionality. Intersectionality places an explicit focus on differences among groups and seeks to illuminate various interacting social factors that affect human lives, including social locations, health status, and quality of life. This paper will draw on recently emerging intersectionality research in the Canadian women's health context in order to explore the promises and practical challenges of the processes involved in applying an intersectionality paradigm. We begin with a brief overview of why the need for an intersectionality approach has emerged within the context of women's health research and introduce current thinking about how intersectionality can inform and transform health research more broadly. We then highlight novel Canadian research that is grappling with the challenges in addressing issues of difference and diversity. In the analysis of these examples, we focus on a largely uninvestigated aspect of intersectionality research - the challenges involved in the process of initiating and developing such projects and, in particular, the meaning and significance of social locations for researchers and participants who utilize an intersectionality approach. The examples highlighted in the paper represent important shifts in the health field, demonstrating the potential of intersectionality for examining the social context of women's lives, as well as developing methods which elucidate power, create new knowledge, and have the potential to inform appropriate action to bring about positive social change.



Catalytically active nanomaterials: a promising candidate for artificial enzymes.  


Natural enzymes, exquisite biocatalysts mediating every biological process in living organisms, are able to accelerate the rate of chemical reactions up to 10(19) times for specific substrates and reactions. However, the practical application of enzymes is often hampered by their intrinsic drawbacks, such as low operational stability, sensitivity of catalytic activity to environmental conditions, and high costs in preparation and purification. Therefore, the discovery and development of artificial enzymes is highly desired. Recently, the merging of nanotechnology with biology has ignited extensive research efforts for designing functional nanomaterials that exhibit various properties intrinsic to enzymes. As a promising candidate for artificial enzymes, catalytically active nanomaterials (nanozymes) show several advantages over natural enzymes, such as controlled synthesis in low cost, tunability in catalytic activities, as well as high stability against stringent conditions. In this Account, we focus on our recent progress in exploring and constructing such nanoparticulate artificial enzymes, including graphene oxide, graphene-hemin nanocomposites, carbon nanotubes, carbon nanodots, mesoporous silica-encapsulated gold nanoparticles, gold nanoclusters, and nanoceria. According to their structural characteristics, these enzyme mimics are categorized into three classes: carbon-, metal-, and metal-oxide-based nanomaterials. We aim to highlight the important role of catalytic nanomaterials in the fields of biomimetics. First, we provide a practical introduction to the identification of these nanozymes, the source of the enzyme-like activities, and the enhancement of activities via rational design and engineering. Then we briefly describe new or enhanced applications of certain nanozymes in biomedical diagnosis, environmental monitoring, and therapeutics. For instance, we have successfully used these biomimetic catalysts as colorimetric probes for the detection of cancer cells, nucleic acids, proteins, metal ions, and other small molecules. In addition, we also introduce three exciting advances in the use of efficient modulators on artificial enzyme systems to improve the catalytic performance of existing nanozymes. For example, we report that graphene oxide could serve as a modulator to greatly improve the catalytic activity of lysozyme-stabilized gold nanoclusters at neutral pH, which will have great potential for applications in biological systems. We show that, through the incorporation of modulator into artificial enzymes, we can offer a facile but highly effective way to improve their overall catalytic performance or realize the catalytic reactions that were not possible in the past. We expect that nanozymes with unique properties and functions will attract increasing research interest and lead to new opportunities in various fields of research. PMID:24437921

Lin, Youhui; Ren, Jinsong; Qu, Xiaogang



Strengthening Chronic Disease Prevention Programming: the Toward Evidence-Informed Practice (TEIP) Program Assessment Tool  

PubMed Central

Best practices identified solely on the strength of research evidence may not be entirely relevant or practical for use in community-based public health and the practice of chronic disease prevention. Aiming to bridge the gap between best practices literature and local knowledge and expertise, the Ontario Public Health Association, through the Toward Evidence-Informed Practice initiative, developed a set of resources to strengthen evidence-informed decision making in chronic disease prevention programs. A Program Assessment Tool, described in this article, emphasizes better processes by incorporating review criteria into the program planning and implementation process. In a companion paper, “Strengthening Chronic Disease Prevention Programming: The Toward Evidence-Informed Practice (TEIP) Program Evidence Tool,” we describe another tool, which emphasizes better evidence by providing guidelines and worksheets to identify, synthesize, and incorporate evidence from a range of sources (eg, peer-reviewed literature, gray literature, local expertise) to strengthen local programs. The Program Assessment Tool uses 19 criteria derived from literature on best and promising practices to assess and strengthen program planning and implementation. We describe the benefits, strengths, and challenges in implementing the tool in 22 community-based chronic disease prevention projects in Ontario, Canada. The Program Assessment Tool helps put best processes into operation to complement adoption and adaptation of evidence-informed practices for chronic disease prevention.

Albert, Dayna; Fortin, Rebecca; Lessio, Anne; Herrera, Christine; Hanning, Rhona; Rush, Brian



Towards practical implementation of bioelectrochemical wastewater treatment.  


Bioelectrochemical systems (BESs), such as microbial fuel cells (MFCs) and microbial electrolysis cells (MECs), are generally regarded as a promising future technology for the production of energy from organic material present in wastewaters. The current densities that can be generated with laboratory BESs now approach levels that come close to the requirements for practical applications. However, full-scale implementation of bioelectrochemical wastewater treatment is not straightforward because certain microbiological, technological and economic challenges need to be resolved that have not previously been encountered in any other wastewater treatment system. Here, we identify these challenges, provide an overview of their implications for the feasibility of bioelectrochemical wastewater treatment and explore the opportunities for future BESs. PMID:18585807

Rozendal, René A; Hamelers, Hubertus V M; Rabaey, Korneel; Keller, Jurg; Buisman, Cees J N



The Promise and the Problems of Epigenetics Biomarkers in Cancer  

PubMed Central

Epigenetics plays an important role in tissue differentiation and phenotypic changes are associated with extensive modifications in epigenetic patterns such as DNA methylation (DNAme), histone methylation and acetylation marks, and micro RNAs. From a diagnostic perspective, DNAme is one of the more tractable epigenetic changes; differentially affecting a large number of genes. Variations can be measured accurately, on any given set of CG sites, by sequencing bisulfite converted DNA. The promise of DNAme is that biomarkers can be found in every kind of gene from rare unstable cell-cycle enzymes to highly expressed structural proteins. Almost any kind of biological specimen is amenable and the changes can be measured in tissue biopsies, scrapes, aspirates, urine, blood and other fluids. To date, hundreds of differentially methylated genes have been identified in cancer that can potentially function as biomarkers. The most common kind of change, studied, is CpG island methylation of tumor suppressor genes that modifies transcription. Despite a great many candidates, few of the DNAme markers have been adequately validated for routine clinical use. Important current limitations of epigenetic biomarkers are that assays are diverse; gene lists are large; comparative data are few, and disagreements in published papers are frequent.

Lorincz, Attila T.



Identifying influential nodes in complex networks  

Microsoft Academic Search

Identifying influential nodes that lead to faster and wider spreading in complex networks is of theoretical and practical significance. The degree centrality method is very simple but of little relevance. Global metrics such as betweenness centrality and closeness centrality can better identify influential nodes, but are incapable to be applied in large-scale networks due to the computational complexity. In order

Duanbing Chen; Linyuan Lü; Ming-Sheng Shang; Yi-Cheng Zhang; Tao Zhou


The Irvine Paraprofessional Program: A Promising Practice for Serving Students with ADHD.  

ERIC Educational Resources Information Center

Describes the Irvin Paraprofessional Program (IPP), a 12-week intensive intervention that includes: (1) direct intervention to children with attention deficit hyperactivity disorder by specially trained paraprofessionals; (2) teacher consultation by the school psychologists on effective classroom management strategies; (3) school-based…

Kotkin, Ronald



Tying Early Childhood Education More Closely to Schooling: Promise, Perils and Practical Problems  

ERIC Educational Resources Information Center

Background: Over the past decade or so, the idea of joining early childhood education (ECE) and schooling has gained currency in the educational reform arena. Numerous education reform proposals and plans include ECE as a component. Scores of school districts around the country have added preschool classrooms to at least some of their elementary…

Halpern, Robert



Teacher Licensure Exams and Black Teacher Candidates: Toward New Theory and Promising Practice  

ERIC Educational Resources Information Center

"Basic skills" teacher licensure exams such as Praxis are the first gatekeepers to the teaching profession. Fewer than half of the aspiring Black teachers who take these exams pass on their first attempt. While critiques of these exams are warranted, critiques alone will do little to help certify more Black teachers. This solution-oriented article…

Petchauer, Emery



Culturally Responsive Pedagogy for African American Students: Promising Programs and Practices for Enhanced Academic Performance  

ERIC Educational Resources Information Center

The academic outcomes for African American students continue to lag behind their White, Latino, and Asian American counterparts. Culturally responsive pedagogy has been purported to be an intervention that may help to reverse the persistent under performance for African American students. This article highlights findings from a three-year study of…

Howard, Tyrone; Terry, Clarence L., Sr.



Creating a Successful, Citywide System of Before- and Afterschool Programs. Promising Practices in Citywide Afterschool Initiatives.  

ERIC Educational Resources Information Center

San Diego is the first major city in the United States with comprehensive before and afterschool programs in every public elementary and middle school within its jurisdiction. This "6 to 6" program currently serves both elementary and middle school students in 204 public schools in the city of San Diego. With a strong public endorsement from San…

National Institute on Out-of-School Time, 2004



Promising Practices for Curbing Disproportionate Representation of Minority Students in Special Education  

ERIC Educational Resources Information Center

The disproportionate representation of minority students in special education programs has been a persistent problem in American education. Being labeled as disabled often has a negative impact on social relationships and self-concept and long-term outcomes such as graduation and employment. Disproportionate identification of students from certain…

Echevarria, Jana; Powers, Kristin; Elliott, Judy



Management and Operations of Online Programs: Ensuring Quality and Accountability. Promising Practices in Online Learning  

ERIC Educational Resources Information Center

Online learning is growing rapidly as states and districts are creating new online schools, and existing programs are adding new courses and students. The growth reflects the spreading understanding that online courses and programs can serve a wide variety of students and needs. These include: (1) Creating opportunities for small and rural school…

Watson, John; Gemin, Butch



Teaching to Expand Opportunities for Nontraditional Students: Promising Strategies and Practices  

ERIC Educational Resources Information Center

The Vocational Equity Research, Training and Evaluation Center (VERTEC) was established in 1988 to increase females' access to, and opportunities in, vocational education programs that are nontraditional for their gender. The research, technical assistance and advocacy that has been provided by VERTEC staff over the last 21 years has established a…

Connecticut Women's Education and Legal Fund, 2009



Using Assessment Results: Promising Practices of Institutions That Do It Well  

ERIC Educational Resources Information Center

Most institutions are collecting evidence of student learning, but it is not clear how these results are being used to improve student outcomes. To learn more about what colleges and universities are doing to use assessment data productively to inform and strengthen undergraduate education, the National Institute for Learning Outcomes Assessment…

Baker, Gianina R.; Jankowski, Natasha A.; Provezis, Staci; Kinzie, Jillian



Promising Practices: Progress toward the Goals, 1999. Lessons for the States.  

ERIC Educational Resources Information Center

This document examines progress in the United States toward the National Education Goals. The data are rooted in the annual report of the National Education Goals Panel (NEGP). The Panel, a bipartisan group, drew on the advice of education experts to select the best available data as indicators of progress. States that performed well or improved…

Wurtz, Emily


Mobilizing Culture, Language, and Educational Practices: Fulfilling the Promises of "Mendez" and "Brown"  

ERIC Educational Resources Information Center

In commemorating the landmark "Brown v. Board of Education" (1954) decision, this lecture also honors the "Mendez v. Westminster" case of 1946, a successful challenge to the segregated schooling of Mexican and Mexican American students in California. The author summarizes the "Mendez" case, its relation to "Brown", and its sociocultural aspects,…

Moll, Luis C.



Promising Practices to Improve Community Performance and Sustainability. Part II. Tips for Better Care.  

National Technical Information Service (NTIS)

The U.S Environmental Protection Agency's (EPA's) Community Action for a Renewed Environment (CARE) Program offers communities an innovative way to reduce the risks from pollution in their environment. The CARE process helps communities build capacity to ...



A Parent's Guide to Choosing the Right Online Program. Promising Practices in Online Learning  

ERIC Educational Resources Information Center

Online learning continues to grow rapidly across the United States and the world, opening new learning opportunities for students and families. Informed estimates put the number of K-12 students in online courses at over 1 million, as parents and students are choosing online courses and schools for a variety of reasons that grow out of their…

Watson, John; Gemin, Butch; Coffey, Marla



Inside Urban Charter Schools: Promising Practices and Strategies in Five High-Performing Schools  

ERIC Educational Resources Information Center

"Inside Urban Charter Schools" offers an unprecedentedly intimate glimpse into the world of charter schools by profiling five high-performing urban charter schools serving predominantly low-income, minority youth in Massachusetts. Interviews, focus groups, and classroom observations conducted over the course of two years flesh out rich and…

Merseth, Katherine K.



Perils and Promises: University Instructors Integration of Technology in Classroom-Based Practices  

ERIC Educational Resources Information Center

Modern technologies such as the Internet present new opportunities for teaching and learning at all educational levels. Today, many universities strive to integrate appropriate technologies into campus classrooms. Despite sizeable investments in hardware, software and supporting infrastructures, little is known about implementation. The purpose of…

Brill, Jennifer M.; Galloway, Chad



Lean Premixed Combustion Stabilized by Low Swirl a Promising Concept for Practical Applications  

NASA Technical Reports Server (NTRS)

Since its inception, the low-swirl burner (LSB) has shown to be a useful laboratory apparatus for fundamental studies of premixed turbulent flames. The LSB operates under wide ranges of equivalence ratios, flow rates, and turbulence intensities. Its flame is lifted and detached from the burner and allows easy access for laser diagnostics. The flame brush is axisymmetric and propagates normal to the incident reactants. Therefore, the LSB is well suited for investigating detailed flame structures and empirical coefficients such as flame speed, turbulence transport, and flame generated turbulence. Due to its capability to stabilize ultra-lean premixed turbulent flames (phi approx. = 0.55), the LSB has generated interest from the gas appliance industry for use as an economical low-NO(x) burner. Lean premixed combustion emits low levels of NO(x), due primarily to the low flame temperature. Therefore, it is a very effective NO(x) prevention method without involving selective catalytic reduction (SCR), fuel-air staging, or flue gas recirculation (FGR). En the gas turbine industry, substantial research efforts have already been undertaken and engines with lean premixed combustors are already in use. For commercial and residential applications, premixed pulsed combustors and premixed ceramic matrix burners are commercially available. These lean premixed combustion technologies, however, tend to be elaborate but have relatively limited operational flexibility, and higher capital, operating and maintenance costs. Consequently, these industries are continuing the development of lean premixed combustion technologies as well as exploring new concepts. This paper summarizes the research effects we have undertaken in the past few years to demonstrate the feasibility of applying the low-swirl flame stabilization method for a wide range of heating and power generation systems. The principle of flame stabilization by low-swirl is counter to the conventional high-swirl methods that rely on a recirculation zone to anchor the flame. In LSBS, flow recirculation is not promoted to allow the premixed turbulent flames to propagate freely. A LSB with an air-jet swirler is essentially an open tube with the swirler at its mid section. The small air-jets generate swirling motion only in the annular region and leaving the central core of the flow undisturbed, When this flow exits the burner tube, the angular momentum generates radial mean pressure gradient to diverge the non-swirling reactants stream. Consequently, the mean flow velocity decreases linearly. Propagating against this decelerating flow, the flame self-sustains at the position where the local flow velocity equals the flame speed, S(sub f). The LSB operates with a swirl number, S, between 0.02 to 0.1. This is much lower than the minimum S of 0.6 required for the high-swirl burners. We found that the swirl number needed for flame stabilization varies only slightly with fuel type, flow velocity, turbulent conditions and burner dimensions (i.e. throat diameter and swirl injection angle).

Cheng, R. K.



Policy and Funding Frameworks for Online Learning. Promising Practices in Online Learning  

ERIC Educational Resources Information Center

In at least 44 states across the country, students are logging in to learn at all times of the day and night--accessing courses they might otherwise be unable to take, interacting with students they might otherwise never know, and working with highly qualified teachers they otherwise could not access. In these and countless other ways, online…

Watson, John; Gemin, Butch



Linking Human Services and Housing Supports to Address Family Homlessness: Promising Practices in the Field.  

National Technical Information Service (NTIS)

Recent reports have brought national attention to the prevalence of family homelessness and the need to coordinate across all levels of government to prevent and end family homelessness. In June 2011, the U.S. Department of Housing and Urban Development (...



Promising Practices for Family Involvement in Schools. Family, School, Community, Partnership Issues, Volume 1.  

ERIC Educational Resources Information Center

Parent involvement as one of the eight National Education Goals has brought heightened awareness to the importance of connecting educational institutions and their communities. This book addresses major frameworks for understanding family involvement and government support of family involvement projects. The work also presents a theoretical base…

Hiatt-Michael, Diana B., Ed.


Tidal Volume Single Breath Washout of Two Tracer Gases - A Practical and Promising Lung Function Test  

PubMed Central

Background Small airway disease frequently occurs in chronic lung diseases and may cause ventilation inhomogeneity (VI), which can be assessed by washout tests of inert tracer gas. Using two tracer gases with unequal molar mass (MM) and diffusivity increases specificity for VI in different lung zones. Currently washout tests are underutilised due to the time and effort required for measurements. The aim of this study was to develop and validate a simple technique for a new tidal single breath washout test (SBW) of sulfur hexafluoride (SF6) and helium (He) using an ultrasonic flowmeter (USFM). Methods The tracer gas mixture contained 5% SF6 and 26.3% He, had similar total MM as air, and was applied for a single tidal breath in 13 healthy adults. The USFM measured MM, which was then plotted against expired volume. USFM and mass spectrometer signals were compared in six subjects performing three SBW. Repeatability and reproducibility of SBW, i.e., area under the MM curve (AUC), were determined in seven subjects performing three SBW 24 hours apart. Results USFM reliably measured MM during all SBW tests (n?=?60). MM from USFM reflected SF6 and He washout patterns measured by mass spectrometer. USFM signals were highly associated with mass spectrometer signals, e.g., for MM, linear regression r-squared was 0.98. Intra-subject coefficient of variation of AUC was 6.8%, and coefficient of repeatability was 11.8%. Conclusion The USFM accurately measured relative changes in SF6 and He washout. SBW tests were repeatable and reproducible in healthy adults. We have developed a fast, reliable, and straightforward USFM based SBW method, which provides valid information on SF6 and He washout patterns during tidal breathing.

Singer, Florian; Stern, Georgette; Thamrin, Cindy; Fuchs, Oliver; Riedel, Thomas; Gustafsson, Per; Frey, Urs; Latzin, Philipp



Making Education Work for Hispanic Americans: Some Promising Community-Based Practices.  

ERIC Educational Resources Information Center

This paper describes the work of the National Council of La Raza to improve education for Hispanic students and their families. It provides an overview of the council's Innovative Education Project, an effort to demonstrate and evaluate effective models for use by affiliated community-based organizations to improve educational outcomes for…

Orum, Lori S.



Microsoft Academic Search

Virtual reality (VR) can be used as a powerful tool to extend the possibilities of visualising the built environment before construction. This paper describes work conducted at Loughborough University in collaboration with a leading British housing developer, and highlights the need to balance the differing agendas of academic research and the competitive modern workplace. Through consultation with our industrial partner

Jennifer Whyte; Dino Bouchlaghem; Tony Thorpe



The Changing Faculty and Student Success: Non-Tenure-Track Faculty Promising Practices  

ERIC Educational Resources Information Center

The nature of the American academic workforce has fundamentally shifted over the past several decades. Whereas full-time tenured and tenure-track faculty were once the norm, more than two-thirds of the professoriate in non-profit postsecondary education is now comprised of non-tenure-track faculty. New hires across all institutional types are now…

Kezar, Adrianna; Maxey, Daniel



Promising Practices: Benefits Planning, Assistance and Outreach Services Provided by Centers for Independent Living  

Microsoft Academic Search

The Benefits Planning, Assistance and Outreach (BPA&O) program has been developed by SSA to provide accurate, current, individualized benefits and work incentives information to people with disabilities. Benefits and work incentives counseling services allow individuals with disabilities to make informed choices and can contribute to their ability to self-advocate around issues of employment. There are currently 113 BPA&O projects covering

JoAnne Malloy; Barbara Otto



Catholic Higher Education: Practice and Promise. Diverse Expressions of Catholic Identity.  

ERIC Educational Resources Information Center

This collection provides transcripts of remarks delivered by five participants in the Association of Catholic Colleges and Universities' meeting at the University of St. Thomas in St. Paul, Minnesota. They include: (1) "The Catholic Intellectual Tradition" (Margaret O'Brien Steinfels), which focuses on the willingness of Catholic institutions to…

Steinfels, Margaret O'Brien; And Others



Addressing the Needs of Victims of Human Trafficking: Challenges, Barriers, and Promising Practices.  

National Technical Information Service (NTIS)

Funded in the fall of 2006, the purpose of this exploratory project is to develop information on how HHS programs are currently addressing the needs of victims of human trafficking, including domestic victims, with a priority focus on domestic youth. This...

H. J. Clawson N. Dutch



Promising Practices for Providing Alternative Media to Postsecondary Students with Print Disabilities  

ERIC Educational Resources Information Center

For postsecondary students with disabilities influencing reading performance, printed class materials pose a substantial barrier and have a negative impact on academic achievement. Digital technologies offer alternative ways of accessing print materials for students with print-related disabilities. Alternative media is a broad term that…

Wolfe, Gerri L.; Lee, Christopher



Education for Adult English Language Learners in the United States: Trends, Research, and Promising Practices  

ERIC Educational Resources Information Center

Adult English language learners comprise a substantial proportion of the adult education population in the United States. In program year 2006-2007, 46% of participants enrolled in state-administered adult education programs were in English as a second language (ESL) classes. This percentage does not include English language learners enrolled in…

Schaetzel, Kirsten; Young, Sarah



Promising Curriculum and Instructional Practices for High-Ability Learners Manual.  

ERIC Educational Resources Information Center

This manual is intended to assist teachers in Nebraska's schools in meeting the needs of high-ability learners in their classrooms. Chapter 1 focuses on curriculum differentiation regarding the content, process, and product. Bloom's taxonomy of thinking is discussed; a list of acceptable student projects for elementary and secondary students is…

Auld, Corrine; Brown, Jane; Duffy, Mary; Falter, Nancy; Hammond, Tom; Jensen, Dennis; Schlager, Carolyn; Senseney, Alice; Ward, Noreen


Making Education Work for Mexican-Americans: Promising Community Practices. ERIC Digest.  

ERIC Educational Resources Information Center

Hispanic students have higher dropout rates and lower academic achievement than Anglo students. While schools have begun to address the issue of underachievement, some community groups have implemented enrichment programs that focus on the affective domain--self-esteem, family values, and cultural pride. This digest describes and synthesizes the…

Sosa, Alicia


Discrimination of SM-identified individuals.  


The belief that sadomasochism (SM) is violence or abusive behavior has resulted in harassment, physical attacks, and discrimination against SM-identified individuals. Historically, they were often opposed by self-identified feminists. One reason the women who practiced SM were targeted was the official opposition to sadomasochistic practices promulgated by the National Organization for Women (NOW). Current statistics of incidents of discrimination, harassment and physical attacks against SM-identified individuals and SM groups are compiled by the National Coalition for Sexual Freedom (NCSF). PMID:16803765

Wright, Susan



Delaware Pushes to Meet Race to Top Promises  

ERIC Educational Resources Information Center

This article reports on how Delaware pushes to meet Race to the Top promises. The Delcastle Technical High School teachers are on the front lines of the push to deliver on promises that last year won Delaware, 10 other states, and the District of Columbia shares of the Race to the Top pie, the $4 billion competition that is driving much of the…

McNeil, Michele



Locating Interim Assessments within Teachers' Assessment Practice  

ERIC Educational Resources Information Center

Promising research on the teaching and learning impact of classroom-embedded formative assessment has spawned interest in a broader array of assessment tools and practices, including interim assessment. Although researchers have begun to explore the impact of interim assessments in the classroom, like other assessment tools and practices, they…

Riggan, Matthew; Olah, Leslie Nabors



The Study on Customer Relationship Management of B2B Enterprise Based on the Brand Promise of Customer Perception  

Microsoft Academic Search

In order to promote CRM strategic research and improve CRM capabilities of the theoretical basis of decision support function, based on the brief analysis of the current situation about B2B customer relationship management, discussed the practical significance of the implementation of the brand promise made in the B2B customer relationship management, and focused on the applications of the four strategies

Wang Bao-li; Tian Hong-yuan; Chen Xin-lan



Arctic Observing Network Data Management: Current Capabilities and Their Promise for the Future  

NASA Astrophysics Data System (ADS)

CADIS (the Cooperative Arctic Data and Information Service) serves as the data management, discovery and delivery component of the Arctic Observing Network (AON). As an International Polar Year (IPY) initiative, AON comprises 34 land, atmosphere and ocean observation sites, and will acquire much of the data coming from the interagency Study of Environmental Arctic Change (SEARCH). CADIS is tasked with ensuring that these observational data are managed for long term use by members of the entire Earth System Science community. Portions of CADIS are either in use by the community or available for testing. We now have an opportunity to evaluate the feedback received from our users, to identify any design shortcomings, and to identify those elements which serve their purpose well and will support future development. This presentation will focus on the nuts-and-bolts of the CADIS development to date, with an eye towards presenting lessons learned and best practices based on our experiences so far. The topics include: - How did we assess our users' needs, and how are those contributions reflected in the end product and its capabilities? - Why did we develop a CADIS metadata profile, and how does it allow CADIS to support preservation and scientific interoperability? - How can we shield the user from metadata complexities (especially those associated with various standards) while still obtaining the metadata needed to support an effective data management system? - How can we bridge the gap between the data storage formats considered convenient by researchers in the field, and those which are necessary to provide data interoperability? - What challenges have been encountered in our efforts to provide access to federated data (data stored outside of the CADIS system)? - What are the data browsing and visualization needs of the AON community, and which tools and technologies are most promising in terms of supporting those needs? A live demonstration of the current capabilities of the CADIS system will be included as time and logistics allow. CADIS is a joint effort of the University Corporation for Atmospheric Research (UCAR), the National Snow and Ice Data Center (NSIDC), and the National Center for Atmospheric Research (NCAR).

Collins, J.; Fetterer, F.; Moore, J. A.



Identifying Students with Emotional Disturbance: School Psychologists' Practices and Perceptions  

ERIC Educational Resources Information Center

From its inception as a disability category in the Education for All Handicapped Children Act, serving students under the special education category Emotional Disturbance (ED) has been a challenging task for school psychologists. In particular, the vague and ambiguous federal definition has created an environment in which inconsistent assessment…

Hanchon, Timothy A.; Allen, Ryan A.



Culturally Identifying the Performance Practices of Astor Piazzolla's Second Quinteto  

Microsoft Academic Search

Astor Piazzolla (1921-1992) captivated Argentine and international audiences with his innovative works in a nuevo tango style and his bandoneón performances. Piazzolla?s success culminated during the 1980s with his second Quinteto, which performed remarkable concerts in venues such as the Teatro Colón in Buenos Aires and the Central Park Bandshell in New York, in addition to the performances at the

Kacey Quin Link



Encouraging SME Participation in Training: Identifying Practical Approaches.  

ERIC Educational Resources Information Center

A case study of training for small- to medium-sized enterprises (SMEs) at a university found that the following factors influenced SME participation: preliminary consultation with SMEs on design and delivery, free half-day workshops in repeated cycles, individual pacing of learning, and business focus. (Contains 14 references.) (JOW)

Johnston, Karen; Loader, Kim



Diagnostic practices to identify iron deficiency in higher plants  

Microsoft Academic Search

Fe chlorosis occurs in many plant species although chlorosis of monocots and dicots generally occurs under different soil and climatic conditions. Because an understanding of causal factors for chlorosis is important in diagnosis, the factors which promote iron chlorosis and the regulation of Fe uptake potential are reviewed.Extractable soil Fe is useful in diagnosing soils which will produce chlorotic monocots,

Rufus L. Chaney



Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis.  


Susceptibly to the induction of rat tongue cancer (TC) by oral 4-nitroquinoline 1-oxide (4NQO) exposure is a polygenic trait. Among several quantitative trait loci identified by crosses between TC-susceptible Dark Agouti (DA) rats and TC-resistant Wistar-Furth (WF) rats, we focused on tongue cancer susceptibility locus (Tcas3) of chromosome 4. We examined tongue carcinogenesis in the reciprocal congenic strains DA.WF-Tcas3 and WF.DA-Tcas3 and in their parental strains. The Tcas3DA allele, and not the Tcas3WF allele, significantly favored tumor latency, incidence and TC number/size. In genomic DNA of TCs induced in (DA x WF) F1 rats, the resistant Tcas3WF allele was frequently and selectively lost, particularly in larger tumors. Thus, we searched the possible candidate genes in the Tcas3 region using microarray analysis of TCs in F1 rats and revealed significant upregulation of 2 cancer-related genes, parathyroid hormone-like hormone (Pthlh) and Kras2. The relevance of the WF allele of Pthlh as a cancer modifier was indicated by 3 single nucleotide polymorphisms specific to this strain. In contrast, no consistent strain-specific variations were found in Kras2. Moreover, the plasma Ca2+ level was consistently higher in DA rats when compared to the level in WF rats bearing TCs; moreover, the Pthlh-mRNA expression level was >30-fold higher in TCs when compared to this level in the normal tongue mucosa. Immunostaining experiments showed strong PTHrP protein expression in TCs of DA rats, and the signal was intensified in larger TCs. Kras2 was also upregulated in TCs, but to a lesser degree than PTHrP. Thus, Pthlh is a promising candidate modifier gene in the development and progression of rat TCs. PMID:24253735

Suwa, Hirohiko; Hirano, Masato; Kawarada, Kouji; Nagayama, Motohiko; Ehara, Michiko; Muraki, Tomonari; Shisa, Hayase; Sugiyama, Aiko; Sugimoto, Masahiro; Hiai, Hiroshi; Kitano, Motoo; Tanuma, Jun-Ichi



Practice management.  


The practicing orthopaedic traumatologist must have a sound knowledge of business fundamentals to be successful in the changing healthcare environment. Practice management encompasses multiple topics including governance, the financial aspects of billing and coding, physician extender management, ancillary service development, information technology, transcription utilization, and marketing. Some of these are universal, but several of these areas may be most applicable to the private practice of medicine. Attention to each component is vital to develop an understanding of the intricacies of practice management. PMID:24918826

Althausen, Peter L; Mead, Lisa



Women and the Reagan Administration: Promises and Realities.  

ERIC Educational Resources Information Center

Compares the Reagan administration's campaign promises to its actual performance in handling women's issues. Administrative appointments, government programs for women in education, science, and business, federal laws and regulations, and social welfare programs affecting women are examined. (AM)

Schafran, Lynn Hecht



New Eczema Drug Shows Promise in Early Trials  


... sharing features on this page, please enable JavaScript. New Eczema Drug Shows Promise in Early Trials Dupilumab ... Eczema THURSDAY, July 10, 2014 (HealthDay News) -- A new drug that scientists hope will relieve the debilitating ...


MEK: A Single Drug Target Shows Promise in Multiple Cancers

Drugs that block the MEK protein have shown promise in several cancers. Trametinib has had encouraging results in patients with advanced melanoma, and selumetinib has been tested in patients with advanced thyroid and ovarian cancers.


Salivary Gland Biopsy Shows Promise to Helping to Diagnose Parkinson's  


... resources & more. Order Free Materials Today Science News Salivary Gland Biopsy Shows Promise to Helping to Diagnose Parkinson’s - ... for example, in the nerve cells of a salivary gland below the floor of the mouth, called the ...


New Drug Shows Promise for Restless Legs Syndrome  


... sharing features on this page, please enable JavaScript. New Drug Shows Promise for Restless Legs Syndrome: Study ... medication in a head-to-head comparison, a new study found. Pramipexole (Mirapex), which is commonly used ...


Identifying mutual engagement  

Microsoft Academic Search

Mutual engagement occurs when people creatively spark together and enter a state of group flow. We present a characterisation of mutually engaging interaction, discuss design features which contribute to mutually engaging interactions, and identify a set of measures for identifying mutual engagement in collaboration. A collaborative music editor's interface features are systematically manipulated in an empirical study of their effect

Nick Bryan-Kinns; Fraser Hamilton



Identifying and Classifying Rocks  

NSDL National Science Digital Library

How do we identify and classify rocks? In this lesson, we are going to learn about different ways that we classify and identify rocks! There are three types of rocks. Sedimentary Metamorphic Igneous As we are learning about the three types of rocks, print out this chart and use it to write down what you learn about each type of ...

Owen, Elisabeth



Identifying Conditional Conservatism  

Microsoft Academic Search

This paper provides guidance for empiricists interested in measuring conditional conservatism and in interpreting associations of those measures with variables of interest. I begin by discussing the nature and importance of conditional conservatism and surveying the literature identifying conditional conservatism. I then describe and comment on the various limitations of asymmetric timeliness identified in the literature. Despite these limitations, I

Stephen G. Ryan



Huntsman Cancer Institute study in zebrafish finds a new compound showing promise in leukemia

A new compound, studied in zebrafish, shows promise in patient leukemia samples when current treatments fail, say researchers from Huntsman Cancer Institute at the University of Utah. Their report appears online in Blood, the Journal of the American Society of Hematology... The researchers used a novel approach that may have a broad range of potential future applications in identifying new drugs for cancer treatment: a line of zebrafish in which immature T cells glow green under fluorescent light.


Changing Practice.  

ERIC Educational Resources Information Center

This serial issue contains nine articles all on the subject of "changing practice," i.e., innovative practices of rural English teachers in the Bread Loaf Rural Teacher Network. "Byte-ing into Medieval Literature" (John Fyler) describes an online conference on medieval literature for rural high school students. "Literacy in Cattle Country" (Dan…

Benson, Chris, Ed.



Metabolomics tools for identifying biomarkers for neuropsychiatric diseases.  


The repertoire of biochemicals (or small molecules) present in cells, tissue, and body fluids is known as the metabolome. Today, clinicians utilize only a very small part of the information contained in the metabolome, as revealed by the quantification of a limited set of analytes to gain information on human health. Examples include measuring glucose or cholesterol to monitor diabetes and cardiovascular health, respectively. With a focus on comprehensively studying the metabolome, the rapidly growing field of metabolomics captures the metabolic state of organisms at the global or "-omics" level. Given that the overall health status of an individual is captured by his or her metabolic state, which is a reflection of what has been encoded by the genome and modified by environmental factors, metabolomics has the potential to have a great impact upon medical practice by providing a wealth of relevant biochemical data. Metabolomics promises to improve current, single metabolites-based clinical assessments by identifying metabolic signatures (biomarkers) that embody global biochemical changes in disease, predict responses to treatment or medication side effects (pharmachometabolomics). State of the art metabolomic analytical platforms and informatics tools are being used to map potential biomarkers for a multitude of disorders including those of the central nervous system (CNS). Indeed, CNS disorders are linked to disturbances in metabolic pathways related to neurotransmitter systems (dopamine, serotonin, GABA and glutamate); fatty acids such as arachidonic acid-cascade; oxidative stress and mitochondrial function. Metabolomics tools are enabling us to map in greater detail perturbations in many biochemical pathways and links among these pathways this information is key for development of biomarkers that are disease-specific. In this review, we elaborate on some of the concepts and technologies used in metabolomics and its promise for biomarker discovery. We also highlight early findings from metabolomic studies in CNS disorders such as schizophrenia, Major Depressive Disorder (MDD), Bipolar Disorder (BD), Amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). PMID:19303440

Quinones, Marlon P; Kaddurah-Daouk, Rima



Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9  

PubMed Central

Alcohol consumption is a known risk factor for hypertension, with recent candidate studies implicating gene-alcohol interactions in blood pressure (BP) regulation. We used 6882 (predominantly) Caucasian participants aged 20–80 years from the Framingham SNP Health Association Resource (SHARe) to perform a genome-wide analysis of SNP-alcohol interactions on BP traits. We used a two-step approach in the ABEL suite to examine genetic interactions with three alcohol measures (ounces of alcohol consumed per week, drinks consumed per week, and the number of days drinking alcohol per week) on four BP traits [systolic (SBP), diastolic (DBP), mean arterial (MAP), and pulse (PP) pressure]. In the first step, we fit a linear mixed model of each BP trait onto age, sex, BMI, and antihypertensive medication while accounting for the phenotypic correlation among relatives. In the second step, we conducted 1 degree-of-freedom (df) score tests of the SNP main effect, alcohol main effect, and SNP-alcohol interaction using the maximum likelihood estimates (MLE) of the parameters from the first step. We then calculated the joint 2 df score test of the SNP main effect and SNP-alcohol interaction using MixABEL. The effect of SNP rs10826334 (near SLC16A9) on SBP was significantly modulated by both the number of alcoholic drinks and the ounces of alcohol consumed per week (p-values of 1.27E-08 and 3.92E-08, respectively). Each copy of the G-allele decreased SBP by 3.79 mmHg in those consuming 14 drinks per week vs. a 0.461 mmHg decrease in non-drinkers. Index SNPs in 20 other loci exhibited suggestive (p-value ? 1E-06) associations with BP traits by the 1 df interaction test or joint 2 df test, including 3 rare variants, one low-frequency variant, and SNPs near/in genes ESRRG, FAM179A, CRIPT-SOCS5, KAT2B, ADCY2, GLI3, ZNF716, SLIT1, PDE3A, KERA-LUM, RNF219-AS1, CLEC3A, FBXO15, and IGSF5. SNP-alcohol interactions may enhance discovery of novel variants with large effects that can be targeted with lifestyle modifications.

Simino, Jeannette; Sung, Yun Ju; Kume, Rezart; Schwander, Karen; Rao, D. C.



Breast Cancer Startup Challenge announces ten winning teams of entrepreneurs; Promising technologies identified to speed cancer research

Ten winners of a world-wide competition to bring emerging breast cancer research technologies to market faster were announced today by the Avon Foundation for Women, in partnership with NCI and the Center for Advancing Innovation (CAI). Avon is providing $250,000 in funding for this Challenge.


Educational Researchers and Practicality  

ERIC Educational Resources Information Center

In this article, an attempt to identify further directions in research designs that researchers can use to contribute to the relevance of educational research findings, by including teachers' practicality issues, is presented. Sixty experienced teachers in secondary education read the reporting of modified experimental research findings about…

Van Velzen, Joke H.



Health Literacy Practices and Educational Competencies for Health Professionals: A Consensus Study  

PubMed Central

Health care professionals often lack adequate knowledge about health literacy and the skills needed to address low health literacy among patients and their caregivers. Many promising practices for mitigating the effects of low health literacy are not used consistently. Improving health literacy training for health care professionals has received increasing emphasis in recent years. The development and evaluation of curricula for health professionals has been limited by the lack of agreed-upon educational competencies in this area. This study aimed to identify a set of health literacy educational competencies and target behaviors, or practices, relevant to the training of all health care professionals. The authors conducted a thorough literature review to identify a comprehensive list of potential health literacy competencies and practices, which they categorized into 1 or more educational domains (i.e., knowledge, skills, attitudes) or a practice domain. The authors stated each item in operationalized language following Bloom's Taxonomy. The authors then used a modified Delphi method to identify consensus among a group of 23 health professions education experts representing 11 fields in the health professions. Participants rated their level of agreement as to whether a competency or practice was both appropriate and important for all health professions students. A predetermined threshold of 70% agreement was used to define consensus. After 4 rounds of ratings and modifications, consensus agreement was reached on 62 out of 64 potential educational competencies (24 knowledge items, 27 skill items, and 11 attitude items), and 32 out of 33 potential practices. This study is the first known attempt to develop consensus on a list of health literacy practices and to translate recommended health literacy practices into an agreed-upon set of measurable educational competencies for health professionals. Further work is needed to prioritize the competencies and practices in terms of relative importance.

Coleman, Clifford A.; Hudson, Stan; Maine, Lucinda L.



[Evidence-based and promising interventions to prevent infectious diseases among youth as a result of poor hand hygiene in schools: a literature review].  


Infectious diseases remain a major cause of death among young people throughout the world. This paper reviews the current knowledge of empirically validated and promising interventions aimed at preventing infectious diseases among children caused by poor hand hygiene in schools. The study used a standard protocol to identify and review the literature and to classify the selected interventions. Approximately ten interventions were found to have a beneficial effect by promoting hand washing and hand hygiene in schools. The study also found that most of the interventions were implemented at elementary school. However, some interventions were also implemented at kindergarten or in child care centers, while others were aimed at university students. Most of the interventions were implemented by teachers, peers and/or external professionals. The study found that hand hygiene is effective regardless of the type of cleaning product used (i.e. antibacterial or plain soap, alcohol-based or alcohol-free hand sanitizer). This study aims to contribute to the understanding of empirically validated and promising interventions and to promote reflection on professional practice in France. PMID:23782636

Malherbe, Hélène; Nugier, Angélique; Clément, Juliette; Lamboy, Béatrice



Toward Teaching a Liberating Sociological Practicality: Challenges for Teaching, Learning and Practice  

ERIC Educational Resources Information Center

Though C. Wright Mills made a pivotal contribution to the discipline by raising sociologists' awareness of the ideological and bureaucratic content of sociological practicality, he may have placed unyielding limits on "the promise" he profoundly proclaimed in the "sociological imagination." By defining types of practicality in such rigidly…

Finkelstein, Marv



Identifying Breast Cancer Oncogenes.  

National Technical Information Service (NTIS)

Breast cancer is attributed to genetic alterations, the majority of which are yet to be characterized. Oncogenic alterations that give rise to breast tumors need to be identified to develop targeted treatment options and consequently, improve clinical out...

Y. Shrestha



Practice Makes Perfect?: Effective Practice Instruction in Large Ensembles  

ERIC Educational Resources Information Center

Helping young musicians learn how to practice effectively is a challenge faced by all music educators. This article presents a system of individual music practice instruction that can be seamlessly integrated within large-ensemble rehearsals. Using a step-by-step approach, large-ensemble conductors can teach students to identify and isolate…

Prichard, Stephanie



Practical Action  

NSDL National Science Digital Library

Founded over 40 years ago by an economist, Practical Action's aim is to help impoverished people "use technology to challenge poverty", to gain "access to technical options and knowledge", and "influence the social, economic and institutional systems for innovation and use of technology." The "Downloads" tab has a link to "Practical Answers" that cover almost two dozen themes and lets users browse the extensive library, submit technical questions to expert, and it also provides users with a section entitled "Share" which documents peoples' experience with Practical Action. Visitors will also find the "Featured Articles" section of the Downloads useful and full of such practical information as "Build Your Own Tippy Tap", for hand washing after toileting and a "Solar Voltaic System Design Info Sheet" that covers electrical design issues. Back on the homepage, visitors will find links to their social networking, e-newsletter, and the latest from their series of blogs.


Formaldehyde: catalytic oxidation as a promising soft way of elimination.  


Compared to other molecules such as benzene, toluene, xylene, and chlorinated compounds, the catalytic oxidation of formaldehyde has been studied rarely. However, standards for the emission level of this pollutant will become more restrictive because of its extreme toxicity even at very low concentrations in air. As a consequence, the development of a highly efficient process for its selective elimination is needed. Complete catalytic oxidation of formaldehyde into CO2 and H2 O using noble-metal-based catalysts is a promising method to convert this pollutant at room temperature, making this process energetically attractive from an industrial point of view. However, the development of a less expensive active phase is required for a large-scale industrial development. Nanomaterials based on oxides of manganese are described as the most promising catalysts. The objective of this Minireview is to present promising recent studies on the removal of formaldehyde through heterogeneous catalysis to stimulate future research in this topic. PMID:23456881

Quiroz Torres, Jhon; Royer, Sébastien; Bellat, Jean-Pierre; Giraudon, Jean-Marc; Lamonier, Jean-François



Identifying priority issues in facilities management benchmarking  

Microsoft Academic Search

Considers the state of benchmarking in facilities management and finds that most academic and practice literature is mainly concerned with measurement techniques, and a formal approach of reducing performance gaps. Limitations are discussed, and the orientation of facilities management performance priorities is questioned. Argues that benchmarking is limited by the ability to identify the priorities, or performance indicators, that can

Gavin McDougall; John Hinks



Identifying Fallacies of Reference in Argumentation  

ERIC Educational Resources Information Center

The experience of teaching informal logic (sometimes called practical logic) at the introductory level over the last fifteen years has allowed the author the opportunity to identify some interesting problems. These problems have been encountered by students attempting to understand some of the ideas presented in the informal logic course and by…

Gough, Jim



From boots to buoys: promises and challenges of dielectric elastomer energy harvesting  

NASA Astrophysics Data System (ADS)

Dielectric elastomers offer the promise of energy harvesting with few moving parts. Power can be produced simply by stretching and contracting a relatively low-cost rubbery material. This simplicity, combined with demonstrated high energy density and high efficiency, suggests that dielectric elastomers are promising for a wide range of energy harvesting applications. Indeed, dielectric elastomers have been demonstrated to harvest energy from human walking, ocean waves, flowing water, blowing wind, and pushing buttons. While the technology is promising, there are challenges that must be addressed if dielectric elastomers are to be a successful and economically viable energy harvesting technology. These challenges include developing materials and packaging that sustains long lifetime over a range of environmental conditions, design of the devices that stretch the elastomer material, as well as system issues such as practical and efficient energy harvesting circuits. Progress has been made in many of these areas. We have demonstrated energy harvesting transducers that have operated over 5 million cycles. We have also shown the ability of dielectric elastomer material to survive for months underwater while undergoing voltage cycling. We have shown circuits capable of 78% energy harvesting efficiency. While the possibility of long lifetime has been demonstrated at the watt level, reliably scaling up to the power levels required for providing renewable energy to the power grid or for local use will likely require further development from the material through to the systems level.

Kornbluh, Roy D.; Pelrine, Ron; Prahlad, Harsha; Wong-Foy, Annjoe; McCoy, Brian; Kim, Susan; Eckerle, Joseph; Low, Tom



Xeroradiography: Stagnated after a Promising Beginning? A Historical Review  

PubMed Central

Various methods have been introduced for obtaining radiographs. Xeroradiography which is a method of imaging uses the xeroradiographic copying process to record images produced by diagnostic x-rays. It differs from halide film technique in that it involves neither wet chemical processing nor the use of dark room. Literature on this subject is scarce. After an initial promising beginning, this imaging method, once thought to hold the key to endodontic imaging, got stagnated. A revisit of this promising endodontic imaging system would therefore be appropriate. The purpose of this study was to review xeroradiographic technique as a roentgenographic imaging system.

Udoye, Christopher I.; Jafarzadeh, Hamid



Ethics in Telehealth Nursing Practice  

Microsoft Academic Search

Telehealth nurses frequently encounter ethical issues in practice. The ability to identify moral dimensions of practice concerns is an important first step in resolving such issues. In this article, some common ethical terms are explained, and typical ethical problems for Telehealth nurses described. A conceptual model applicable to Telehealth nursing is presented and discussed as a framework for ethical reflection.

Carol Rutenberg; Kathleen Oberle



Identifying broadcast content  

US Patent & Trademark Office Database

In a broadcast system (210) each broadcast content item is identified by a broadcast Content Reference Identifier (CRID). In a storage device (220) with a storage (240) each broadcast content item is identified by a local CRID. A processor (230) stores a CRID list that includes for CRIDs an associated validity interval including a starting date and an ending date during which interval the CRID is unique for the content item. When the processor receives (400) a broadcast CRID, it determines (410) an initial validity interval for the broadcast CRID. The initial validity interval includes a starting date and an ending date during which interval the broadcast CRID is unique for the broadcast content item. It then determines (420) whether the initial validity interval overlaps with a validity interval stored in the CRID list for an identical CRID. If there is no overlap it adds (430) the broadcast CRID to the CRID list.



Learning to Identify Referents.  

ERIC Educational Resources Information Center

Children (ages 5-8) were presented with a communication task under four different experimental conditions, to find contexts which would encourage their use of the indefinite article. Even older children failed to identify their referents consistently, although nearly all subjects used indefinite expressions intermittently when mentioning new…

Warden, David



Identifying Heavy Higgs Bosons.  

National Technical Information Service (NTIS)

Two techniques for identifying heavy Higgs bosons produced at SSC energies are discussed. In the first, the Higgs boson decays into ZZ, with one Z decaying into an e-pair or mu -pair and the other into a neutrino pair. In the second, the production of the...

R. N. Cahn



Identifying Exceptional Schools.  

ERIC Educational Resources Information Center

Statistical techniques for identifying exceptional school progress are outlined and illustrated. Regression analyses using two sets of test scores are suggested as a preliminary indicator. These techniques would be useful to school administrators. School progress is best measured by criterion referenced tests rather than norm referenced tests.…

Kippel, Gary



Translating learning into practice  

PubMed Central

PROBLEM ADDRESSED The need for effective and accessible educational approaches by which family physicians can maintain practice competence in the face of an overwhelming amount of medical information. OBJECTIVE OF PROGRAM The practice-based small group (PBSG) learning program encourages practice changes through a process of small-group peer discussion—identifying practice gaps and reviewing clinical approaches in light of evidence. PROGRAM DESCRIPTION The PBSG uses an interactive educational approach to continuing professional development. In small, self-formed groups within their local communities, family physicians discuss clinical topics using prepared modules that provide sample patient cases and accompanying information that distils the best evidence. Participants are guided by peer facilitators to reflect on the discussion and commit to appropriate practice changes. CONCLUSION The PBSG has evolved over the past 15 years in response to feedback from members and reflections of the developers. The success of the program is evidenced in effect on clinical practice, a large and increasing number of members, and the growth of interest internationally.

Armson, Heather; Kinzie, Sarah; Hawes, Dawnelle; Roder, Stefanie; Wakefield, Jacqueline; Elmslie, Tom




ERIC Educational Resources Information Center




Valuing Diversity: A Well-Intended but Empty Promise  

ERIC Educational Resources Information Center

When professional development in diversity is provided to educators in the field, it usually targets classroom practice with the intent of closing the achievement gap. These efforts are critical. But work should not stop there because culture underlies every policy, practice, and procedure in the school and influences every thought, interaction,…

Guerra, Patricia L.



Educational Leadership at 2050: Conjectures, Challenges, and Promises  

ERIC Educational Resources Information Center

This is a practical, bold, no-holds barred look at challenges facing educational leaders and the university programs that prepare them through mid-century. It examines key continuities and discontinuities of current times for school, education, and society. Both practice and preparation occur in contested social space, the implications of which…

Papa, Rosemary; Mullen, Carol A.; English, Fenwick W.; Creighton, Theodore



Every Child Every Promise Workforce Readiness. Issue Brief  

ERIC Educational Resources Information Center

The third "Every Child, Every Promise" research brief focuses on the large percentage of the children and youth who will enter the workforce over the next two decades are lacking enough of the "soft" or applied skills--such as teamwork, decision-making, and communication--that will help them become effective employees and managers. The report…

America's Promise Alliance (NJ1), 2007



The Promise and Challenge of Next Generation Information Technology  

Microsoft Academic Search

The Promise and Challenge of Next Generation Information Technology Bruce Gibbard Brookhaven National Laboratory The dramatic evolution in computing hard ware observed during the last twenty years seems certain to continue at least through the first decade of the 21st century. This evolution will directly account for important quantitative changes in what will be possible in the world of information

Bruce Gibbard



Construction of an Ethernet Model with the 'PROMISE' Simulation Tool.  

National Technical Information Service (NTIS)

The paper describes the construction and verification of an Ethernet model with the aid of the 'PROMISE' simulation tool. Ethernet is a packet-switching, broadcast, multi-access local area network, using carrier sense and collision detection as access pro...

G. Wedzinga



Promising New Teacher Support Strategies and Their Costs.  

ERIC Educational Resources Information Center

Describes several promising new teacher support strategies implemented by California universities and their district partners as part of the California New Teacher Project, noting resources expended to implement each strategy. The strategies are framed according to their programmatic and economic dimensions. Strategies that make the most sense…

Dianda, Marcella R.; Quartz, Karen Hunter



Keeping the Promise? The Debate over Charter Schools  

ERIC Educational Resources Information Center

"Keeping the Promise?" examines one of the most complex reforms in education: charter schools. This wide-ranging and thought-provoking collection of essays examines the charter school movement's founding visions, on-the-ground realities, and untapped potential-within the context of an unswerving commitment to democratic, equitable public schools.…

Walters, Stephanie



The promise of genetically engineered mice for cancer prevention studies  

Microsoft Academic Search

Sophisticated genetic technologies have led to the development of mouse models of human cancers that recapitulate important features of human oncogenesis. Many of these genetically engineered mouse models promise to be very relevant and relatively rapid systems for determining the efficacy of chemopreventive agents and their mechanisms of action. The validation of such models for chemoprevention will help the selection

Tamaro Hudson; Jeffrey E. Green



Public health's promise for the future: 1989 Presidential address  

Microsoft Academic Search

Public health's promise for the future is inextricably related to efforts which maximize human potential and which realize the world's interdependence. Public health challenges are not only constant and complex but frequently surrounded by political activities. In this environment, the public health enterprise has been enhanced by the Institute of Medicine, National Academy of Sciences' report on The Future of

I S Shannon



Contextualized Teaching & Learning: A Promising Approach for Basic Skills Instruction  

ERIC Educational Resources Information Center

Contextualized teaching and learning (CTL), or the concept of relating subject matter content to meaningful situations that are relevant to students' lives, offers one promising approach to helping students learn more effectively. This brief offers instructors, college leaders, policy makers and funders a high-level summary of the CTL…

Baker, Elaine DeLott; Hope, Laura; Karandjeff, Kelley



Journey to Freedom: Reflecting on Our Responsibilities, Renewing Our Promises  

ERIC Educational Resources Information Center

Over the past four decades, tribal colleges and universities (TCUs) have emerged as a cutting-edge approach to post-secondary education in the United States and across the world. They have emerged as exceptional institutions--and their leaders still have promises to keep and new goals to achieve. As people look to the future of the tribal…

Bull, Cheryl Crazy



Defense Launch: A Key Dimension of the Promise of Space.  

National Technical Information Service (NTIS)

Lyndon Johnson saw much promise in the U S space program in its early years. As President, he followed the agenda set by his immediate predecessors, Presidents Kennedy and Eisenhower; their long-term leadership is one of the major reasons why the space pr...

L. S. Kelly



78 FR 63913 - Proposed Priority-Promise Zones  

Federal Register 2010, 2011, 2012, 2013

...have the opportunity to earn a decent living when they reach adulthood. Since 2009, the President has provided tools to combat poverty...plan to ensure that hard-working Americans make it to the middle class. Promise Zones will align the work of multiple...



Prevention of Mental Disorders: Promises, Limitations, and Barriers  

ERIC Educational Resources Information Center

In the past few years, the field of psychology has seen a dramatic increase in interest in the prevention of mental disorder and emotional difficulties. This special series provides some excellent examples of the promises held by a variety of prevention programs. At the same time, the papers in this volume highlight several important issues to…

Rapee, Ronald M.



Solar Eclipse: The Failure of a Promising Technology  

Microsoft Academic Search

This study analyzes the reasons a promising technology fails and brings forth the ramifications of such a failure. The analysis is done on solar car technology; specifically, the path of the MIT Solar Electric Vehicle Team, the conversion of its founder to electric v ehicle manufacturing, and the absence of solar cars from the market today. The results show that

Amit Goyal; Rania Khalaf; Amar Mehta; Ashutosh Somani; Paritosh Somani


The Promise of Global Networks. 1999 Annual Review.  

ERIC Educational Resources Information Center

This collection of commissioned papers provides a variety of perspectives on the impact of global information networks. The following articles are included: "The Promise of Global Networks: An Introduction" (Jorge Reina Schement); "Architecture and Expectations: Networks of the World--Unite!" (Marjory S. Blumenthal); "The Regulation of Global…

Institute for Information Studies, Queenstown, MD.


The Challenge and Promise of a Catholic University.  

ERIC Educational Resources Information Center

This book offers 30 papers on the continuing discussion of the nature of a Catholic university. The papers are: "Introduction: The Challenge and Promise of a Catholic University" (Theodore M. Hesburgh); "Reflections on the Mission of a Catholic University" (Harold W. Attridge); "The Difference of a Catholic University" (Otto Bird); "A Catholic…

Hesburgh, Theodore M., Ed.


Race to Top Promises Come Home to Roost  

ERIC Educational Resources Information Center

Grant recipients risk losing millions of dollars in Race to the Top money if they fail to live up to their promises, federal education officials make clear. By threatening to revoke Hawaii's $75 million Race to the Top award for failing to make "adequate progress" on key milestones of its education reform plan, U.S. Secretary of Education Arne…

McNeil, Michele



Passport to College: Promise Scholarship Program Status Report  

ERIC Educational Resources Information Center

The Passport to College Promise Scholarship program was created by the 2007 Washington State Legislature (House Bill 1131) to help former foster youth prepare for and succeed in college. This status report addresses four areas: (1) proposed scholarship and student support approaches; (2) estimates of the number of students who will receive…

Washington Higher Education Coordinating Board, 2008




Microsoft Academic Search

Religious education has changed considerably over the 100 years of the Religious Education Association (REA); urgency has increased for human communities to honor diversity. The focus of this article is realities, visions, and promises of cultural diversity. The article includes an overview of REA's recent history, exemplifying its efforts and limitations in diversity. It then turns to five commentaries on

Mary Elizabeth Moore; Boyung Lee; Katherine Turpin; Ralph Casas; Lynn Bridgers; Veronice Miles



Promising pharmacological, molecular and cellular treatments of autoimmune hepatitis.  


Current corticosteroid regimens are effective in autoimmune hepatitis, but therapy can be complicated by side effects, disease progression, incomplete response, and relapse after drug withdrawal. The aims of this review are to describe the promising pharmacological, molecular and cellular interventions for autoimmune hepatitis and to stimulate further investigations that can refresh or replace current treatments. Murine models that introduce pertinent human disease-related antigens by vaccination or viral infection promise a resource by which to evaluate new treatments. Promising new drug therapies include the calcineurin-inhibitors (cyclosporine, tacrolimus), next generation purine antagonists (mycophenolate mofetil, 6-thioguanine nucleotides), next generation glucocorticoids (budesonide, deflazacort), and inhibitors of the mammalian target of rapamycin (rapamycin). Feasible molecular interventions are recombinant molecules that affect immune regulatory pathways (cytotoxic T lymphocyte antigen 4, recombinant interleukin 10), monoclonal antibodies that disrupt activation pathways (antibodies to CD3, CD28, CD 20, or tumor necrosis factor-?), and synthetic peptides that block antigen display or promote antigen desensitization (oral tolerance). New methods to stimulate or replenish regulatory T cell populations (adoptive transfer, mesenchymal stem cell or autologous bone marrow transplantation) are feasible as are genetic manipulations (gene silencing) and gene supplementations (gene replacement therapy). The emergence of new therapies for autoimmune hepatitis requires a standardized and universalized animal model of the human disease, consensus regarding the most promising modality to be tested, and formation of a cooperative international network of committed clinical investigators to evaluate new therapies in a pre-designed rigorous yet expeditious fashion. PMID:21902661

Czaja, Albert J



Transcendent professionalism: keeping promises and living the questions.  


Wynia and colleagues propose a definition of professionalism as a belief system by which to shape health care rather than a list of values and behaviors. The belief that professionalism is the best way to organize and deliver health care constitutes a promise to society. The notion that the medical profession as a whole as well as its individual members should be held accountable to standards of competence, ethical values, and interpersonal attributes developed, declared, and enforced by the profession itself is also a promise to society. The author argues that good promises offer a stabilizing influence over the inherent uncertainty in human relationships and may provide the ground for a lasting trustworthy relationship between the medical profession and society; however, the professionalism belief system itself is vulnerable if the promise is breached. The modern world has challenged the professionalism model of organizing health care, and individual practitioners as well as their professional organizations are seeking clarity about what professionalism means given current realities. This commentary reflects on these circumstances and provides some recommendations for developing a construct of professionalism. PMID:24667519

Leach, David C



Meet the Promise of Content Standards: Investing in Professional Learning  

ERIC Educational Resources Information Center

New standards alone will not prepare all students for college and careers. The success of the Common Core State Standards depends on educators' capacity to make the instructional shifts the standards require. Meeting the promise of content standards cannot be achieved merely by agreeing on and publishing the new standards. Effective teaching of…

Killion, Joellen; Hirsh, Stephanie



Promise and Challenges of Microalgal-Derived Biofuels  

Microsoft Academic Search

Microalgae offer great promise to contribute a significant portion of the renewable fuels that will be required by the Renewable Fuels Standard described in the 2007 Energy Independence and Security Act of the United States. Algal biofuels would be based mainly on the high lipid content of the algal cell and thus would be an ideal feedstock for high energy

Philip T. Pienkos; Al Darzins



Multiplication Practice  

NSDL National Science Digital Library

Practice Your Multiplication Skills! Watch These Fun Multiplication Videos *Need a review? Watch the Multiplication is Repeated Addition Video Four Legged Zoo I ve Got 6 Ready or Not Here I Come (5s) Twelve Toes Elementary My Dear 2s Figure 8 Lucky 7s Video My Hero Zero Naughty Number 9 Practice your multiplication skills with these fun games: Multiplication Facts Become the king of multiplication with Castle Quest Dish up some ice cream with Crazy Cone Multiplication. Earn disco moves to make a dinosaur dance with Disco Dino. Design your own granny and make her race in a ...

Lerdahl, Miss



Hunting Icebergs: Identifying Icebergs  

NSDL National Science Digital Library

This self-paced, interactive tutorial guides learners through the decision-making process in locating data that will enable the identification of tabular icebergs, including: selecting the appropriate satellite orbit, and identifying the optimal solar and infrared wavelength values to discriminate between water and ice in remotely-sensed images. This resource is part of the tutorial series, Satellite Observations in Science Education, and is the first of three modules in the tutorial, Hunting Icebergs. (Note: requires Java plug-in)


How to identify the genetic basis of gastrointestinal and liver diseases?  

PubMed Central

New insights into the genetic basis of disease are being generated at an ever increasing rate. This explosion of information was ignited by technological advances, such as the polymerase chain reaction and automated DNA sequencing. Although its promise is great, the integration of genetics into the everyday practice of medicine remains challenging. This review discusses the application of molecular genetics in general with a specific focus on hereditary diseases of the digestive organs. The application of molecular genetics in everyday clinical routine is hampered by the difficult interpretation of test results. These difficulties include the prediction of disease penetrance, the presence of multiple mutations of a particular gene with varying functional consequences, and the importance of exogenous factors modulating disease expression. To date, the most significant impact of genetics has been to increase our understanding of disease aetiology and pathogenesis and to reliably identify siblings of affected patients with the risk to develop symptomatic disease.

Ferenci, P



The Practical Turn in Teacher Education: Designing a Preparation Sequence for Core Practice Frames  

ERIC Educational Resources Information Center

Amid calls for more practice-based teacher education, this article presents a concrete illustration of a practice-based bridging strategy for preparing high school biology teachers to enact open-inquiry labs. Open-inquiry labs were considered a core practice frame that served as a context for identifying core practices and for giving coherence to…

Janssen, Fred; Westbroek, Hanna; Doyle, Walter



A Broken Promise: Examining the Merit-Aid Policy and Implementation Gap in the Michigan Promise Scholarship  

ERIC Educational Resources Information Center

In 2006, Michigan changed their traditional merit award to a credit contingent program based upon successful completion of 60 college credits. The Michigan Promise Scholarship was crafted by state policymakers without input from the financial aid community. This case study suggests that the change in policy resulted in two unintended consequences:…

Daun-Barnet, Nathan; Hermsen, Albert; Vedder, Lori; Mabry, Beth



The Practice  

ERIC Educational Resources Information Center

Consulting for a moment such luminaries as Mahatma Gandhi, Dr. King, Cesar Chavez--I would say that personal revelation is not less necessary to radical change than public revolution. Amen? "Backing Away From The Product" really has to be both a spiritual practice and a public embarrassment so extreme that its witnesses won't stop talking about it…

Billy, Reverend



Best Practices  

NSDL National Science Digital Library

Front-page articles in science and education periodicals and journals give voice to the growing concern that scores on nationwide science exams have either declined or, at best, have had a minute increase even after several years of pushing for better science learning. With this reality facing science education, being knowledgeable about some best practices in science instruction is important.

Swango, C. J.; Steward, Sally B.



On identified predictive control  

NASA Technical Reports Server (NTRS)

Self-tuning control algorithms are potential successors to manually tuned PID controllers traditionally used in process control applications. A very attractive design method for self-tuning controllers, which has been developed over recent years, is the long-range predictive control (LRPC). The success of LRPC is due to its effectiveness with plants of unknown order and dead-time which may be simultaneously nonminimum phase and unstable or have multiple lightly damped poles (as in the case of flexible structures or flexible robot arms). LRPC is a receding horizon strategy and can be, in general terms, summarized as follows. Using assumed long-range (or multi-step) cost function the optimal control law is found in terms of unknown parameters of the predictor model of the process, current input-output sequence, and future reference signal sequence. The common approach is to assume that the input-output process model is known or separately identified and then to find the parameters of the predictor model. Once these are known, the optimal control law determines control signal at the current time t which is applied at the process input and the whole procedure is repeated at the next time instant. Most of the recent research in this field is apparently centered around the LRPC formulation developed by Clarke et al., known as generalized predictive control (GPC). GPC uses ARIMAX/CARIMA model of the process in its input-output formulation. In this paper, the GPC formulation is used but the process predictor model is derived from the state space formulation of the ARIMAX model and is directly identified over the receding horizon, i.e., using current input-output sequence. The underlying technique in the design of identified predictive control (IPC) algorithm is the identification algorithm of observer/Kalman filter Markov parameters developed by Juang et al. at NASA Langley Research Center and successfully applied to identification of flexible structures.

Bialasiewicz, Jan T.



Programs of Promise. A Summary of Current Programs Focusing on the Recruitment of Minority Candidates to Careers in Professional Education.  

ERIC Educational Resources Information Center

This report presents the findings of a study group that is in the process of identifying and gathering information about currently operational programs designed to recruit minority persons to careers in education and retain students in teacher preparation programs. Descriptions of 45 promising programs are organized under four cluster headings:…

Appalachia Educational Lab., Charleston, WV.


Identifying a Theft Suspect  

NSDL National Science Digital Library

This model-eliciting activity (MEA) challenges students to develop a model for predicting the characteristics of a person who has committed a crime. Students work with real data on shoe length, height, and gender to develop the model. Students write a report to the crime victim that identifies a suspect and justifies their decision. The activity sets the stage for students to learn about regression models, and reinforces their understanding of central tendency and variability. It is suggested that this activity be used prior to a formal introduction to linear relationships.

This page was authored by the CATALST Group at the University of Minnesota, based on an activity developed by Roxy Peck at California Polytechnic State University that is based on an original idea by Tom Short, John Carroll University, and Iddo Gal, University of Haifa, Israel.


Is chemoprevention practical?  

Microsoft Academic Search

Breast cancer chemoprevention is practical only if 1) it reduces the incidence of cancer and overall mortality in a cost-effective\\u000a manner, and 2) an easily identified target population is willing to undergo treatment. In the past decade, it was demonstrated\\u000a that breast cancer risk reduction is possible with tamoxifen and raloxifene and is cost effective on the higher end of

Carol J. Fabian; Bruce F. Kimler



Amaryllidaceae Isocarbostyril Alkaloids and Their Derivatives as Promising Antitumor Agents  

PubMed Central

This review covers the isolation, total synthesis, biologic activity, and more particularly the in vitro and in vivo antitumor activities of naturally occurring isocarbostyril alkaloids from the Amaryllidaceae family. Starting from these natural products, new derivatives have been synthesized to explore structure-activity relationships within the chemical class and to obtain potential candidates for preclinical development. This approach appears to be capable of providing novel promising anticancer agents.

Ingrassia, Laurent; Lefranc, Florence; Mathieu, Veronique; Darro, Francis; Kiss, Robert



Tissue engineering: a promising therapeutic approach to necrotizing enterocolitis.  


Tissue engineering is a promising potential candidate for treating intestinal failure resulting from necrotizing enterocolitis. This requires the acquisition, preparation and implantation of autologous organoid units. This may be affected by the complexities of periods of storage of viable donor tissue and delayed implantation. This chapter addresses the development, methodology, and application of tissue-engineered intestine in the experimental and clinical setting. Tissue engineering has the potential of avoiding the inherent toxicities of intestinal transplantation and prolonged immunosuppression. PMID:23611615

Grant, Christa N; Grikscheit, Tracy C



Sporting embodiment: sports studies and the (continuing) promise of phenomenology  

Microsoft Academic Search

Whilst in recent years sports studies have addressed the calls ‘to bring the body back in’ to theorisations of sport and physical activity, the ‘promise of phenomenology’ remains largely under?realised with regard to sporting embodiment. Relatively few accounts are grounded in the ‘flesh’ of the lived sporting body, and phenomenology offers a powerful framework for such analysis. A wide?ranging, multi?stranded



Discovery AND Therapeutic Promise OF Selective Androgen Receptor Modulators  

PubMed Central

Androgens are essential for male development and the maintenance of male secondary characteristics, such as bone mass, muscle mass, body composition, and spermatogenesis. The main disadvantages of steroidal androgens are their undesirable physicochemical and pharmacokinetic properties. The recent discovery of nonsteroidal selective androgen receptor modulators (SARMs) provides a promising alternative for testosterone replacement therapies with advantages including oral bioavailability, flexibility of structural modification, androgen receptor specificity, tissue selectivity, and the lack of steroid-related side effects.

Chen, Jiyun; Kim, Juhyun; Dalton, James T.



Promises of stem cell therapy for retinal degenerative diseases  

Microsoft Academic Search

With the development of stem cell technology, stem cell-based therapy for retinal degeneration has been proposed to restore\\u000a the visual function. Many animal studies and some clinical trials have shown encouraging results of stem cell-based therapy\\u000a in retinal degenerative diseases. While stem cell-based therapy is a promising strategy to replace damaged retinal cells and\\u000a ultimately cure retinal degeneration, there are

Ian Yat-Hin Wong; Ming-Wai Poon; Rosita Tsz-Wai Pang; Qizhou Lian; David Wong


Twenty Years of Promises: Fullerene in Medicinal Chemistry  

NASA Astrophysics Data System (ADS)

Many biological activities have been envisioned for fullerenes and some of them seem to be very promising. The lack of solubility in biologically friendly environments is the major obstacle in the development of this field. The possibility of multiple fuctionalization can be exploited to get more soluble compounds but, up to now, only a few polyadducts, presenting perfectly defined geometry, can be selectively prepared avoiding long purification processes.

da Ros, Tatiana


Strengthening Chronic Disease Prevention Programming: The Toward Evidence-Informed Practice (TEIP) Program Evidence Tool  

PubMed Central

In public health and chronic disease prevention there is increasing priority for effective use of evidence in practice. In Ontario, Canada, despite various models being advanced, public health practitioners are seeking ways to identify and apply evidence in their work in practical and meaningful ways. In a companion article, “Strengthening Chronic Disease Prevention Programming: The Toward Evidence-Informed Practice (TEIP) Program Assessment Tool,” we describe use of a tool to assess and strengthen program planning and implementation processes using 19 criteria derived from best and promising practices literature. In this article, we describe use of a complementary Program Evidence Tool to identify, synthesize, and apply a range of evidence sources to strengthen the content of chronic disease prevention programming. The Program Evidence Tool adapts tools of evidence-based medicine to the unique contexts of community-based health promotion and chronic disease prevention. Knowledge management tools and a guided dialogue process known as an Evidence Forum enable community stakeholders to make appropriate use of evidence in diverse social, political, and structural contexts. Practical guidelines and worksheets direct users through 5 steps: 1) define an evidence question, 2) develop a search strategy, 3) collect and synthesize evidence, 4) interpret and adapt evidence, and 5) implement and evaluate. We describe the Program Evidence Tool’s benefits, strengths, challenges, and what was learned from its application in 4 Ontario public health departments. The Program Evidence Tool contributes to the development and understanding of the complex use of evidence in community-based chronic disease prevention.

Albert, Dayna; Fortin, Rebecca; Herrera, Christine; Hanning, Rhona; Lessio, Anne; Rush, Brian



Toward cardiovascular MRI at 7 T: clinical needs, technical solutions and research promises  

PubMed Central

Objective To consider potential clinical needs, technical solutions and research promises of ultrahigh-field strength cardiovascular MR (CMR). Methods A literature review is given, surveying advantages and disadvantages of CMR at ultrahigh fields (UHF). Key concepts, emerging technologies, practical considerations and applications of UHF CMR are provided. Examples of UHF CMR imaging strategies and their added value are demonstrated, including the numerous unsolved problems. A concluding section explores future directions in UHF CMR. Results UHF CMR can be regarded as one of the most challenging MRI applications. Image quality achievable at UHF is not always exclusively defined by signal-to-noise considerations. Some of the inherent advantages of UHF MRI are offset by practical challenges. But UHF CMR can boast advantages over its kindred lower field counterparts by trading the traits of high magnetic fields for increased temporal and/or spatial resolution. Conclusions CMR at ultrahigh-field strengths is a powerful motivator, since speed and signal may be invested to overcome the fundamental constraints that continue to hamper traditional CMR. If practical challenges can be overcome, UHF CMR will help to open the door to new approaches for basic science and clinical research.

Sodickson, Daniel K.; Krombach, Gabriele A.; Schulz-Menger, Jeanette




SciTech Connect

The identification and characterization of numerous collisional families-clusters of bodies with a common collisional origin-in the asteroid belt has added greatly to the understanding of asteroid belt formation and evolution. More recent study has also led to an appreciation of physical processes that had previously been neglected (e.g., the Yarkovsky effect). Collisions have certainly played an important role in the evolution of the Kuiper Belt as well, though only one collisional family has been identified in that region to date, around the dwarf planet Haumea. In this paper, we combine insights into collisional families from numerical simulations with the current observational constraints on the dynamical structure of the Kuiper Belt to investigate the ideal sizes and locations for identifying collisional families. We find that larger progenitors (r {approx} 500 km) result in more easily identifiable families, given the difficulty in identifying fragments of smaller progenitors in magnitude-limited surveys, despite their larger spread and less frequent occurrence. However, even these families do not stand out well from the background. Identifying families as statistical overdensities is much easier than characterizing families by distinguishing individual members from interlopers. Such identification seems promising, provided the background population is well known. In either case, families will also be much easier to study where the background population is small, i.e., at high inclinations. Overall, our results indicate that entirely different techniques for identifying families will be needed for the Kuiper Belt, and we provide some suggestions.

Marcus, Robert A.; Ragozzine, Darin; Murray-Clay, Ruth A.; Holman, Matthew J., E-mail: [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States)



Hombres Sanos: Evaluation of a Social Marketing Campaign for Heterosexually Identified Latino Men Who Have Sex With Men and Women  

PubMed Central

Objectives. We evaluated the effectiveness of Hombres Sanos [Healthy Men] a social marketing campaign to increase condom use and HIV testing among heterosexually identified Latino men, especially among heterosexually identified Latino men who have sex with men and women (MSMW). Methods. Hombres Sanos was implemented in northern San Diego County, California, from June 2006 through December 2006. Every other month we conducted cross-sectional surveys with independent samples of heterosexually identified Latino men before (n = 626), during (n = 752), and after (n = 385) the campaign. Respondents were randomly selected from 12 targeted community venues to complete an anonymous, self-administered survey on sexual practices and testing for HIV and other sexually transmitted infections. About 5.6% of respondents (n = 98) were heterosexually identified Latino MSMW. Results. The intervention was associated with reduced rates of recent unprotected sex with both females and males among heterosexually identified Latino MSMW. The campaign was also associated with increases in perception of HIV risk, knowledge of testing locations, and condom carrying among heterosexual Latinos. Conclusions. Social marketing represents a promising approach for abating HIV transmission among heterosexually identified Latinos, particularly for heterosexually identified Latino MSMW. Given the scarcity of evidence-based HIV prevention interventions for these populations, this prevention strategy warrants further investigation.

Zellner, Jennifer A.; Sanudo, Fernando; Fernandez-Cerdeno, Araceli; Hovell, Melbourne F.; Sipan, Carol L.; Engelberg, Moshe; Carrillo, Hector



List identifies threatened ecosystems  

NASA Astrophysics Data System (ADS)

The International Union for Conservation of Nature (IUCN) announced on 9 September that it will develop a new Red List of Ecosystems that will identify which ecosystems are vulnerable or endangered. The list, which is modeled on the group's Red List of Threatened Species™, could help to guide conservation activities and influence policy processes such as the Convention on Biological Diversity, according to the group. “We will assess the status of marine, terrestrial, freshwater, and subterranean ecosystems at local, regional, and global levels,” stated Jon Paul Rodriguez, leader of IUCN's Ecosystems Red List Thematic Group. “The assessment can then form the basis for concerted implementation action so that we can manage them sustainably if their risk of collapse is low or restore them if they are threatened and then monitor their recovery.”

Showstack, Randy



Practical model \\  

Microsoft Academic Search

Objective: The authors have developed a clinical model of limited cone-beam X-ray CT for dental use and started to use the model in clinical practice. It is called “3DX multi image micro CT” (3DX, J. Morita, Kyoto, Japan). Presented here is a report about the result. Method: We made a design of limited cone-beam X-ray CT so that it could

Yoshinori Arai; Kazuya Honda; Kazuo Iwai; Koji Shinoda



Change What? Identifying Quality Improvement Targets by Investigating Usual Mental Health Care  

Microsoft Academic Search

Efforts to improve community-based children’s mental health care should be based on valid information about effective practices\\u000a and current routine practices. Emerging research on routine care practices and outcomes has identified discrepancies between\\u000a evidence-based practices and “usual care.” These discrepancies highlight potentially potent quality improvement interventions.\\u000a This article reviews existing research on routine or “usual care” practice, identifies strengths and

Ann F. Garland; Leonard Bickman; Bruce F. Chorpita



Establishing a group practice "without walls".  


The group practice "without walls" has become a health care delivery system that is preferred by an increasing number of physicians. This article traces the experience of Premier Medical Group, PC, a "second generation" clinic without walls in the Denver Metropolitan area, to highlight the potential benefits and the key issues related to the development and implementation of a group practice-without-walls model of health-care delivery. The model promises to address physician business and professional needs by building on the best aspects of a traditional group practice, in an overall organizational structure that maximizes each physician's autonomy, individual practice style, and practice identity. The successful implementation of a group practice without walls depends upon physician leadership and impetus, clear goals-and-objectives, competent professional staff, and legal-and-financial guidance. PMID:10123389

Schryver, D L; Niederman, G A; Johnson, B A



Classroom Examination Practices in a Postsecondary Setting  

ERIC Educational Resources Information Center

The literature on college examination practices is relatively sparse, which is surprising given their importance for student learning and motivation. The authors investigated the examination practices of 215 faculty at a comprehensive university in order to identify which practices are normative and to examine relationships among key variables.…

Wininger, Steven R.; Kuhlenschmidt, Sally



Correlates of infection control practices in dentistry  

Microsoft Academic Search

Background: Studies conducted in the first decade of the AIDS epidemic indicated that, in general, dentists had suboptimal levels of compliance with standard infection control practices, including work practices designed to reduce exposure to bloodborne pathogens. This study was designed to assess current rates of compliance with these practices in a population of Maryland dentists and to identify correlates of

Robyn R. M. Gershon; Christine Karkashian; David Vlahov; Martha Grimes; Elizabeth Spannhake



Brain Matters: Practicing Religion, Forming the Faithful  

ERIC Educational Resources Information Center

Religious practices have long drawn on the social sciences to broaden our understanding of how human beings develop, learn, relate, and are formed. While the religion and science conversations have not always been friendly, a growing number of theologians and scientists are engaged in promising dialogues where the interests of both parties…

Hogue, David A.



Towards practical implementation of bioelectrochemical wastewater treatment  

Microsoft Academic Search

Bioelectrochemical systems (BESs), such as microbial fuel cells (MFCs) and microbial electrolysis cells (MECs), are generally regarded as a promising future technology for the production of energy from organic material present in wastewaters. The current densities that can be generated with laboratory BESs now approach levels that come close to the requirements for practical applications. However, full-scale implementation of bioelectrochemical

René A. Rozendal; Hubertus V. M. Hamelers; Korneel Rabaey; Jurg Keller; Cees J. N. Buisman



Identifying risk: the limitations of incident reporting.  


Incident reporting is considered an important source of risk management data for identifying and addressing the causes of errors that occur in health-care organizations. However, the effectiveness of incident reporting in accurately identifying risk may be influenced by variables in the structure and design of incident reporting systems. Several variables, including data bias, system usability, non-standardized terminology and coding, and deficiencies in combined data analysis can reduce risk data accuracy. Until incident reporting systems are enhanced and an environment of safety is promoted, incident reports can provide only a glimmer of insight into organizational risk and quality improvement. Practice environments that support shared decision-making and collaborative care teams and provide stimulating learning opportunities can enhance professional nursing practice and inspire a culture of patient safety. PMID:17410923

Burkoski, Vanessa



Using EHRs to integrate research with patient care: promises and challenges  

PubMed Central

Clinical research is the foundation for advancing the practice of medicine. However, the lack of seamless integration between clinical research and patient care workflow impedes recruitment efficiency, escalates research costs, and hence threatens the entire clinical research enterprise. Increased use of electronic health records (EHRs) holds promise for facilitating this integration but must surmount regulatory obstacles. Among the unintended consequences of current research oversight are barriers to accessing patient information for prescreening and recruitment, coordinating scheduling of clinical and research visits, and reconciling information about clinical and research drugs. We conclude that the EHR alone cannot overcome barriers in conducting clinical trials and comparative effectiveness research. Patient privacy and human subject protection policies should be clarified at the local level to exploit optimally the full potential of EHRs, while continuing to ensure participant safety. Increased alignment of policies that regulate the clinical and research use of EHRs could help fulfill the vision of more efficiently obtaining clinical research evidence to improve human health.

Appelbaum, Paul; Hripcsak, George; Kronish, Ian; Busacca, Linda; Davidson, Karina W; Bigger, J Thomas



Ecotourism: the Promise and Perils of Environmentally Oriented Travel  

NSDL National Science Digital Library

Cambridge Scientific Abstracts (CSA) latest Hot Topics feature is Ecotourism: the Promise and Perils of Environmentally-Oriented Travel, prepared by Heather E. Lindsay. The detailed report explores the opportunities and pitfalls of ecotourism, for which "finding a compromise between preservation and development is often challenging, and can generate additional environmental problems for the very regions it is intended to protect." Key citations for the report link to the full-text articles from scholarly journals in the CSA database, and over two dozen related Web links are also provided. Anyone interested in reviewing the impact of ecotourism will appreciate this well-organized, thorough report.

Lindsay, Heather E.



MHD/steam electrical power production - Promise, progress and problems  

NASA Astrophysics Data System (ADS)

The MHD/Steam Power Plant has promise to burn coal and produce electrical power more efficiently than conventional coal fired plants while producing less environmental intrusion. Problems have been encountered in developing a high temperature air heater (HTAH) using coal exhaust products. Early commercial plants have been proposed that use either a gasifier to produce clean fuel for a separately fired HTAH or use oxygen enrichment to avoid the need for a HTAH. Component development is progressing rapidly but test data is needed at intermediate sizes before a commercial plant can be designed with high confidence of success. Related commercial technology is being adapted for the steam bottoming plant.

Chapman, J. N.; Strom, S. S.; Wu, Y. C. L.



Biomarkers of coronary artery disease: the promise of the transcriptome.  


The last years have witnessed tremendous technical advances in the field of transcriptomics that enable the simultaneous assessment of nearly all transcripts expressed in a tissue at a given time. These advances harbor the potential to gain a better understanding of the complex biological systems and for the identification and development of novel biomarkers. This article will review the current knowledge of transcriptomics biomarkers in the cardiovascular field and will provide an overview about the promises and challenges of the transcriptomics approach for biomarker identification. PMID:24950674

Siemelink, Marten Antoon; Zeller, Tanja



N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents  

PubMed Central

A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 ?M) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 ?M) of Leishmania infantum. Both the high activity of these chloroquine analogues and their mild-to-low toxicity toward host cells make them promising leads for the discovery of new antileishmanial agents.

Vale-Costa, S.; Costa-Gouveia, J.; Perez, B.; Silva, T.; Teixeira, C.; Gomes, P.



New cancer drug shows promise for treating advanced melanoma

Researchers from UCLA's Jonsson Comprehensive Cancer Center report that a new drug in preliminary tests has shown promising results with very manageable side effects for treating patients with melanoma, the deadliest form of skin cancer. The results were presented at the 2013 meeting of the American Society of Clinical Oncology today in Chicago by Dr. Antoni Ribas, professor of medicine in the UCLA division of hematology-oncology, who led the research. Following Ribas’ presentation, the study was published online ahead of press in the New England Journal of Medicine.


Youth Mentoring: Program and Mentor Best Practices  

ERIC Educational Resources Information Center

Youth mentoring programs have been on the rise for the past few decades, yet little has been done to synthesize best practices, as identified in existing research, for programs or mentors to follow. In a review of the literature on mentoring, eight different types of mentoring relationships were identified along with four program best practices

Anastasia, Trena T.; Skinner, Rebecca L.; Mundhenk, Samantha E.



Identifying Adolescent Sleep Problems  

PubMed Central

Objectives To examine the efficacy of self-report and parental report of adolescent sleep problems and compare these findings to the incidence of adolescents who fulfill clinical criteria for a sleep problem. Sleep and daytime functioning factors that predict adolescents’ self-identification of a sleep problem will also be examined. Method 308 adolescents (aged 13–17 years) from eight socioeconomically diverse South Australian high schools participated in this study. Participants completed a survey battery during class time, followed by a 7-day Sleep Diary and the Flinders Fatigue Scale completed on the final day of the study. Parents completed a Sleep, Medical, Education and Family History Survey. Results The percentage of adolescents fulfilling one or more of the criteria for a sleep problem was inordinately high at 66%. Adolescent self-reporting a sleep problem was significantly lower than the adolescents who had one or more of the clinical criteria for a sleep problem (23.1% vs. 66.6%; ?2?=?17.46, p<.001). Parental report of their adolescent having a sleep problem was significantly lower than adolescent self-report (14.3% vs. 21.1%, p<.001). Adolescents who reported unrefreshing sleep were 4.81 times more likely to report a sleep problem. For every hour that bedtime was delayed, the odds of self-reporting a sleep problem increased by 1.91 times, while each additional 10 minutes taken to fall asleep increased the odds 1.40 times. Conclusion While many adolescents were found to have sleep patterns indicative of a sleep problem, only a third of this number self-identify having a sleep problem, while only a sixth of this number are indicated by parental report. This study highlights important features to target in future sleep education and intervention strategies for both adolescents and parents.

Short, Michelle A.; Gradisar, Michael; Gill, Jason; Camfferman, Danny



Evaluation of Patient Centered Medical Home Practice Transformation Initiatives  

PubMed Central

Background The patient-centered medical home (PCMH) has become a widely cited solution to the deficiencies in primary care delivery in the United States. To achieve the magnitude of change being called for in primary care, quality improvement interventions must focus on whole-system redesign, and not just isolated parts of medical practices. Methods Investigators participating in 9 different evaluations of Patient Centered Medical Home implementation shared experiences, methodological strategies, and evaluation challenges for evaluating primary care practice redesign. Results A year-long iterative process of sharing and reflecting on experiences produced consensus on 7 recommendations for future PCMH evaluations: (1) look critically at models being implemented and identify aspects requiring modification; (2) include embedded qualitative and quantitative data collection to detail the implementation process; (3) capture details concerning how different PCMH components interact with one another over time; (4) understand and describe how and why physician and staff roles do, or do not evolve; (5) identify the effectiveness of individual PCMH components and how they are used; (6) capture how primary care practices interface with other entities such as specialists, hospitals, and referral services; and (7) measure resources required for initiating and sustaining innovations. Conclusions Broad-based longitudinal, mixed-methods designs that provide for shared learning among practice participants, program implementers, and evaluators are necessary to evaluate the novelty and promise of the PCMH model. All PCMH evaluations should as comprehensive as possible, and at a minimum should include a combination of brief observations and targeted qualitative interviews along with quantitative measures.

Crabtree, Benjamin F.; Chase, Sabrina M.; Wise, Christopher G.; Schiff, Gordon D.; Schmidt, Laura A.; Goyzueta, Jeanette R.; Malouin, Rebecca A.; Payne, Susan M. C.; Quinn, Michael T.; Nutting, Paul A.; Miller, William L.; Jaen, Carlos Roberto



Restaurant food cooling practices.  


Improper food cooling practices are a significant cause of foodborne illness, yet little is known about restaurant food cooling practices. This study was conducted to examine food cooling practices in restaurants. Specifically, the study assesses the frequency with which restaurants meet U.S. Food and Drug Administration (FDA) recommendations aimed at reducing pathogen proliferation during food cooling. Members of the Centers for Disease Control and Prevention's Environmental Health Specialists Network collected data on food cooling practices in 420 restaurants. The data collected indicate that many restaurants are not meeting FDA recommendations concerning cooling. Although most restaurant kitchen managers report that they have formal cooling processes (86%) and provide training to food workers on proper cooling (91%), many managers said that they do not have tested and verified cooling processes (39%), do not monitor time or temperature during cooling processes (41%), or do not calibrate thermometers used for monitoring temperatures (15%). Indeed, 86% of managers reported cooling processes that did not incorporate all FDA-recommended components. Additionally, restaurants do not always follow recommendations concerning specific cooling methods, such as refrigerating cooling food at shallow depths, ventilating cooling food, providing open-air space around the tops and sides of cooling food containers, and refraining from stacking cooling food containers on top of each other. Data from this study could be used by food safety programs and the restaurant industry to target training and intervention efforts concerning cooling practices. These efforts should focus on the most frequent poor cooling practices, as identified by this study. PMID:23212014

Brown, Laura Green; Ripley, Danny; Blade, Henry; Reimann, Dave; Everstine, Karen; Nicholas, Dave; Egan, Jessica; Koktavy, Nicole; Quilliam, Daniela N



Identifying the Educationally Influential Physician: A Systematic Review of Approaches  

ERIC Educational Resources Information Center

Introduction: Previous studies have indicated that educationally influential physicians' (EIPs) interactions with peers can lead to practice changes and improved patient outcomes. However, multiple approaches have been used to identify and investigate EIPs' informal or formal influence on practice, which creates study outcomes that are difficult…

Kronberger, Matthew P.; Bakken, Lori L.



Predicting sudden cardiac death from T wave alternans of the surface electrocardiogram: promise and pitfalls  

NASA Technical Reports Server (NTRS)

Sudden cardiac death remains a preeminent public health problem. Despite advances in preventative treatment for patients known to be at risk, to date we have been able to identify, and thus treat, only a small minority of these patients. Therefore, there is a major need to develop noninvasive diagnostic technologies to identify patients at risk. Recent studies have demonstrated that measurement of microvolt-level T wave alternans is a promising technique for the accurate identification of patients at risk for ventricular arrhythmias and sudden cardiac death. In this article, we review the clinical data establishing the relationship between microvolt T wave alternans and susceptibility to ventricular arrhythmias. We also review the methods and technology that have been developed to measure microvolt levels of T wave alternans noninvasively in broad populations of ambulatory patients. In particular, we examine techniques that permit the accurate measurement of T wave alternans during exercise stress testing.

Rosenbaum, D. S.; Albrecht, P.; Cohen, R. J.



Cultural Capital: The Promises and Pitfalls in Education Research  

ERIC Educational Resources Information Center

The past three decades have seen the increased use of the term "cultural capital" in classrooms, research articles, and discussions in education. This monograph is an attempt to buttress a theoretical understanding of the cultural capital construct and its applicability to educational research and practice. In educational research, cultural…

Winkle-Wagner, Rachelle



Both Promise and Peril: Information Technology and Experiential Education.  

ERIC Educational Resources Information Center

Because new information-age learning models incorporate experiential education theories and practices, integration of information technology is an opportunity to integrate experiential methods. Scenarios are presented for integrating technology into experiential curricula. Problems include cost, training, lack of quality software, and…

Stringer, L. Allison



Review of "Charter School Autonomy: A Half-Broken Promise"  

ERIC Educational Resources Information Center

This report concludes that autonomy is a prerequisite for innovative and effective charter schools to emerge. Especially important is freedom from external bureaucratic control. Yet there is nothing in this report that addresses levels of autonomy in relationship to financial performance, resource allocation practices, academic results, and other…

Gulosino, Charisse



The Promise and the Caution of Resilience Models for Schools  

ERIC Educational Resources Information Center

Resilience is a very useful construct for framing school mental health services to children and is particularly applicable to mental health services in school settings. Still, resilience perspectives should not be overgeneralized to school mental health practice because risk and resilience wax and wane over time and daily decisions about students'…

Doll, Beth; Jones, Kristin; Osborn, Allison; Dooley, Kadie; Turner, April



The Rise of the Teleworker: False Promises and Responsive Solutions  

ERIC Educational Resources Information Center

The purpose of this exploratory study was to gain a better understanding of how to provide learning opportunities to improve teaching practices for the increasing numbers of academics who are choosing to work online from remote offices, sometimes called e-academics, remote workers, or teleworkers. The objectives of the study were twofold: (1) to…

Kanuka, Heather; Jugdev, Kam; Heller, Robert; West, Dan



Decentralization and School Improvement: Can We Fulfill the Promise?  

ERIC Educational Resources Information Center

In this book, eight contributors examine issues related to the likely effects of the decentralization of school governance on educational practice. Two major themes emerge in the book. The first (chapters 1 through 4) is that governance reforms in education may have little to do with what actually happens in schools, but have much to do with…

Hannaway, Jane, Ed.; Carnoy, Martin, Ed.


Emerging cancer vaccines: the promise of genetic vectors.  


Therapeutic vaccination against cancer is an important approach which, when combined with other therapies, can improve long-term control of cancer. In fact, the induction of adaptive immune responses against Tumor Associated Antigens (TAAs) as well as innate immunity are important factors for tumor stabilization/eradication. A variety of immunization technologies have been explored in last decades and are currently under active evaluation, such as cell-based, protein, peptide and heat-shock protein-based cancer vaccines. Genetic vaccines are emerging as promising methodologies to elicit immune responses against a wide variety of antigens, including TAAs. Amongst these, Adenovirus (Ad)-based vectors show excellent immunogenicity profile and have achieved immunological proof of concept in humans. In vivo electroporation of plasmid DNA (DNA-EP) is also a desirable vaccine technology for cancer vaccines, as it is repeatable several times, a parameter required for the long-term maintenance of anti-tumor immunity. Recent findings show that combinations of different modalities of immunization (heterologous prime/boost) are able to induce superior immune reactions as compared to single-modality vaccines. In this review, we will discuss the challenges and requirements of emerging cancer vaccines, particularly focusing on the genetic cancer vaccines currently under active development and the promise shown by Ad and DNA-EP heterologous prime-boost. PMID:24212974

Aurisicchio, Luigi; Ciliberto, Gennaro



Cancer immunotherapy: accomplishments to date and future promise.  


Cancer remains a devastating disease as existing therapies are too often ineffective and toxicities remain unacceptably high. Immunotherapies for cancer offer the promise of the specificity and memory of the immune system against malignant cells to achieve durable cure with minimal toxicity. Beginning with the success of bone marrow transplantation for blood-borne cancers, and the more recent development of monoclonal antibody therapeutics for a variety of tumors, immunotherapies are already among the most successful class of treatments for cancer. Greater understanding of immunoregulatory mechanisms and improved techniques for immune cell manipulation and engineering have led to new immunomodulatory approaches and cell-based therapies for cancer that have generated great excitement within the biomedical community. As these technologies continue to improve, and as new approaches for harnessing the power and specificity of the immune system are developed, immunotherapies will play an increasingly important role in the treatment of cancer. Here, we review the history of immunotherapies for cancer and discuss existing and emerging immunotherapy technologies that hope to translate the promise of immunotherapy into clinical reality. PMID:24116914

Helmy, Karim Y; Patel, Shyam A; Nahas, George R; Rameshwar, Pranela



Public health's promise for the future: 1989 Presidential address  

SciTech Connect

Public health's promise for the future is inextricably related to efforts which maximize human potential and which realize the world's interdependence. Public health challenges are not only constant and complex but frequently surrounded by political activities. In this environment, the public health enterprise has been enhanced by the Institute of Medicine, National Academy of Sciences' report on The Future of Public Health and the assessment framework it provides. Risk reduction through preventive and health promotion activities is the primary focus of public health, but facilitation is often dependent upon society's understanding and willingness-to-pay for such services. The effectiveness of public health is related to an ability to coordinate public and private efforts at national, state, and local levels. Also in this environment, public health is empowered through its multidisciplinary approach. However, epidemiology provides a unifying framework for the collective public health effort. Based on the use of epidemiology, public health is empowered to make the argument for a national health program and to support the concept of health as a determinant of life options. Public health's promise for the future can be fulfilled by continuing to increase its scientific base for decision-making, by self-examination and correction, by advocating and promoting self-examination and correction, by advocating and promoting social justice and by promoting firm partnerships with the public.

Shannon, I.S. (Rush Univ., Chicago, IL (USA))



Five yogic practices and their relation to psychological distress  

Microsoft Academic Search

While yoga is more popular than ever with the American public, empirical research on yoga has lagged behind its growing popularity. Initial investigations of its practices have been promising but more research is needed. This study took measures to determine whether experience with each of five yogic practices was associated with decreased psychological distress. It was hypothesized that levels of

Michael P Butler



The Road to Nowhere: The Illusion and Broken Promises of Special Education in the Baltimore City and Other Public School Systems. The Abell Report. Volume 17, No.4  

ERIC Educational Resources Information Center

Students with disabilities across the nation, including Baltimore City, are failing to achieve their academic potential. Inadequate instruction and other inappropriate or unlawful practices cause and conceal the dysfunction of special education. At long last, the illusion and broken promises of special education have been publicly exposed. Under…

Hettleman, Kalman R.



Clinical practice  

PubMed Central

The most important goal of introducing noninvasive ventilation (NIV) has been to decrease the need for intubation and, therefore, mechanical ventilation in newborns. As a result, this technique may reduce the incidence of bronchopulmonary dysplasia (BPD). In addition to nasal CPAP, improvements in sensors and flow delivery systems have resulted in the introduction of a variety of other types of NIV. For the optimal application of these novelties, a thorough physiological knowledge of mechanics of the respiratory system is necessary. In this overview, the modern insights of noninvasive respiratory therapy in newborns are discussed. These aspects include respiratory support in the delivery room; conventional and modern nCPAP; humidified, heated, and high-flow nasal cannula ventilation; and nasal intermittent positive pressure ventilation. Finally, an algorithm is presented describing common practice in taking care of respiratory distress in prematurely born infants.

de Vries, Machteld A. G.; Zimmermann, Luc J. I.



EZID: Long term identifiers made easy (Invited)  

NASA Astrophysics Data System (ADS)

Scholarly research is producing ever increasing amounts of digital research data, and this data should be managed throughout the research life cycle both as part of good scientific practice, but also to comply with funder mandates, such as the 2013 OSTP Public Access Memo ( By assigning unique and persistent identifiers to data objects, data managers can gain control and flexibility over what can be a daunting task. This is due to the fact that the objects can be moved to new locations without disruption to links, as long as the identifier target is maintained. EZID is a tool that makes assigning and maintaining unique, persistent identifiers easy. It was designed and built by California Digital Library (CDL) and has both a user interface and a RESTful API. EZID currently offers services for two globally unique, persistent identifier schemes: Digital Object Identifiers (DOIs) and Archival Resource Keys (ARKs). DOIs are identifiers originating from the publishing world and are in widespread use for journal articles. CDL is able to offer DOIs because of being a founding member of DataCite (, an international consortium established to provide easier access to scientific research data on the Internet. ARKs are identifiers originating from the library, archive and museum community. Like DOIs, they become persistent when the objects and identifier forwarding information is maintained. DOIs and ARKs have a key role in data management and, therefore, in data management plans. DOIs are the recommended identifier for use in data citation, and ARKs provide the maximum flexibility needed for data documentation and management throughout the early phases of a project. The two identifier schemes are able to be used together, and EZID is made to work with both. EZID clients, coming from education, research, government, and the private sector, are utilizing the tool for these use cases and more.

Starr, J.



Preparing Mathematics and Science Teachers for Diverse Classrooms: Promising Strategies for Transformative Pedagogy  

NSDL National Science Digital Library

This book provides a theoretical basis and practical strategies to counter resistance to learning to teach for diversity (in culturally and gender-inclusive ways), and resistance to teaching for understanding (using student-centered and inquiry-based pedagogical approaches). Teacher educators from across the United States present rich narratives of their experiences in helping prospective and practicing teachers learn to teach for diversity and for understanding in a variety of mathematics and science contexts. Mathematics and science education has been slow to respond to issues of diversity and equity. Preparing Mathematics and Science Teachers for Diverse Classrooms: Promising Strategies for Transformative Pedagogy helps to begin a network for support and collaboration among teacher educators in science and mathematics who work for multicultural education and equity. A unique and much-needed contribution, this book is an essential resource for teacher educators, K-12 teachers who work as student teacher supervisors and cooperating teachers, and graduate students in mathematics and science education, and a compelling text for science and mathematics methods courses.



Omics approaches in food safety: fulfilling the promise?  


Genomics, transcriptomics, and proteomics are rapidly transforming our approaches to the detection, prevention, and treatment of foodborne pathogens. Microbial genome sequencing in particular has evolved from a research tool into an approach that can be used to characterize foodborne pathogen isolates as part of routine surveillance systems. Genome sequencing efforts will not only improve outbreak detection and source tracking, but will also create large amounts of foodborne pathogen genome sequence data, which will be available for data-mining efforts that could facilitate better source attribution and provide new insights into foodborne pathogen biology and transmission. Although practical uses and application of metagenomics, transcriptomics, and proteomics data and associated tools are less prominent, these tools are also starting to yield practical food safety solutions. PMID:24572764

Bergholz, Teresa M; Moreno Switt, Andrea I; Wiedmann, Martin



Time to Talk: 5 Things to Know about Complementary Health Practices for Cognitive Function, Dementia, and Alzheimer's ...  


... as several mind and body practices such as music therapy and mental imagery, which have shown promise ... of some mind and body practices such as music therapy suggest they may be helpful for some ...


Ultrahigh porosity in mesoporous MOFs: promises and limitations.  


Mesoporous MOFs are currently record holders in terms of the specific surface area with values exceeding 7000 m(2) g(-1), a textural feature unattained by traditional porous solids such as zeolites, carbons and even by graphene. They are promising candidates for high pressure gas storage and also for conversion or separation of larger molecules, whose size exceeds the pore size of zeolites. The rational strategies for synthesis of mesoporous MOF are outlined and the unambiguous consistent assessment of the surface area of such ultrahighly porous materials, as well as present challenges in the exciting research field, of mesoporous MOFs are discussed. The crystallinity, dynamic properties, functional groups, and wide range tunability render these materials as exceptional solids, but for the implementation in functional devices and even in industrial processes several aspects and effective characteristics (such as volumetric storage capacities, recyclability, mechanical and chemical stability, activation) should be addressed. PMID:24722662

Senkovska, Irena; Kaskel, Stefan



Stem cells as promising therapeutic options for neurological disorders.  


Due to the limitations of pharmacological and other current therapeutic strategies, stem cell therapies have emerged as promising options for treating many incurable neurologic diseases. A variety of stem cells including pluripotent stem cells (i.e., embryonic stem cells and induced pluripotent stem cells) and multipotent adult stem cells (i.e., fetal brain tissue, neural stem cells, and mesenchymal stem cells from various sources) have been explored as therapeutic options for treating many neurologic diseases, and it is becoming obvious that each type of stem cell has pros and cons as a source for cell therapy. Wise selection of stem cells with regard to the nature and status of neurologic dysfunctions is required to achieve optimal therapeutic efficacy. To this aim, the stem cell-mediated therapeutic efforts on four major neurological diseases, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and stroke, will be introduced, and current problems and future directions will be discussed. PMID:23097262

Yoo, Jongman; Kim, Han-Soo; Hwang, Dong-Youn



Neuronal Signal Transduction Pathways: Wasteland or the Promised Land?  

NSDL National Science Digital Library

Proteins used in signal transduction pathways are commonly found in different cell types and organs. However, specific proteins whose expression is highly restricted are also utilized for allowing discrete responsiveness to signals that are otherwise ignored by other cells. How the brain uses common and specific signal proteins for communication within and beyond the cerebrum has been an area of intense study. A new book concentrates on the signaling that occurs in the brain under normal and pathological conditions--memory, apoptosis, neurodegeneration, depression, and drug dependence--and is filled with chapters written by experts in neurobiology and neurophysiology. Bryan Roth reviews the book and discusses in detail several chapters that may lead to promising future research.

Bryan L. Roth (Cleveland;Case Western Reserve University REV)



Pathogenesis and promising non-invasive markers for preeclampsia  

PubMed Central

Preeclampsia is one of the leading causes of maternal mortality/morbidity and preterm delivery in the world, affecting 3% to 5% of pregnant women. The pathophysiology of preeclampsia likely involves both maternal and fetal/placental factors. Abnormalities in the development of placental vessels early in pregnancy may result in placental hypoperfusion, hypoxia, or ischemia. Hypoperfusion, hypoxia, and ischemia are critical components in the pathogenesis of preeclampsia because the hypoperfused placenta transfers many factors into maternal vessels that alter maternal endothelial cell function and lead to the systemic symptoms of preeclampsia. There are several hypotheses to explain the pathogenesis of preeclampsia, including altered angiogenic balance, circulating angiogenic factors (such as marinobufagenin, a bufadienolide trigger), and activation of the renin-angiotensin system. Epigenetically-modified cell-free nucleic acids that circulate in plasma and serum might be novel markers with promising non-invasive clinical applications in the diagnosis of preeclampsia.



Pityriasis rubra pilaris: evolution of challenges in promising treatment options.  


Pityriasis rubra pilaris is an uncommon inflammatory dermatosis that is well recognized across the globe. Erythroderma is a common presentation. A precise diagnosis of pityriasis rubra pilaris is based on morphologic features and is classified into 6 types: classic adult onset (type I), atypical adult (type II), classic juvenile (type III), circumscribed juvenile (type IV), atypical juvenile (type V), and human immunodeficiency virus-associated (type VI). Several conventional systemic and/or topical treatments are currently in use. Largely, their results are unsatisfactory and limited by long-term toxicity. The authors investigate the efficacy of a wide spectrum of drugs by examining historical (archive) and promising (modern) treatment modalities for the treatment of pityriasis rubra pilaris. PMID:22324172

Sehgal, Virendra N; Srivastava, Govind; Verma, Prashant



The promise of the anti-idiotype concept  

PubMed Central

A basic tenet of antibody-based immunity is their specificity to antigenic determinates from foreign pathogen products to abnormal cellular components such as in cancer. However, an antibody has the potential to bind to more than one determinate, be it an antigen or another antibody. These observations led to the idiotype network theory (INT) to explain immune regulation, which has wax and waned in enthusiasm over the years. A truer measure of the impact of the INT is in terms of the ideas that now form the mainstay of immunological research and whose roots are spawned from the promise of the anti-idiotype concept. Among the applications of the INT is understanding the structural implications of the antibody-mediated network that has the potential for innovation in terms of rational design of reagents with biological, chemical, and pharmaceutical applications that underlies concepts of reverse immunology which is highlighted herein.

Kieber-Emmons, Thomas; Monzavi-Karbassi, Bejatohlah; Pashov, Anastas; Saha, Somdutta; Murali, Ramachandran; Kohler, Heinz



Prevention of peritoneal adhesions: A promising role for gene therapy  

PubMed Central

Adhesions are the most frequent complication of abdominopelvic surgery, yet the extent of the problem, and its serious consequences, has not been adequately recognized. Adhesions evolved as a life-saving mechanism to limit the spread of intraperitoneal inflammatory conditions. Three different pathophysiological mechanisms can independently trigger adhesion formation. Mesothelial cell injury and loss during operations, tissue hypoxia and inflammation each promotes adhesion formation separately, and potentiate the effect of each other. Studies have repeatedly demonstrated that interruption of a single pathway does not completely prevent adhesion formation. This review summarizes the pathogenesis of adhesion formation and the results of single gene therapy interventions. It explores the promising role of combinatorial gene therapy and vector modifications for the prevention of adhesion formation in order to stimulate new ideas and encourage rapid advancements in this field.

Atta, Hussein M



Gene therapy for gastric cancer: Is it promising?  

PubMed Central

Gastric cancer is one of the most common tumors worldwide. The therapeutic outcome of conventional therapies is inefficient. Thus, new therapeutic strategies are urgently needed. Gene therapy is a promising molecular alternative in the treatment of gastric cancer, including the replacement of defective tumor suppressor genes, the inactivation of oncogenes, the introduction of suicide genes, genetic immunotherapy, anti-angiogenetic gene therapy, and virotherapy. Improved molecular biological techniques and a better understanding of gastric carcinogenesis have allowed us to validate a variety of genes as molecular targets for gene therapy. This review provides an update of the new developments in cancer gene therapy, new principles, techniques, strategies and vector systems, and shows how they may be applied in the treatment of gastric cancer.

Sutter, Andreas P; Fechner, Henry



Scrap tire recycling: Promising high value applications. Final report  

SciTech Connect

Surface modification of scrap tire rubber (rubber particles treated with chlorine gas) show promise for ameliorating the scrap tire problem (the treated rubber can be used as a component in high- performance, expensive polymer systems). The process has been proven in Phase I. Phase II covers market/applications, process development (Forberg-design mixer reactor was chosen), plant design, capital cost estimate, economics environmental/safety/health, and energy impact. Almost of the small amount of chlorine is consumed. The capital costs for a rubber particle treatment facility are attractive, being at least two orders of magnitude less than that of facilities for making new polymer materials. Large volume markets using treated rubber are needed. The amount of scrap rubber available is small compared to the polymers available for replacement. 7 tabs, 16 figs.

Bauman, B.D.; Leskovyansky, P.J.; Drela, H.



Maternal serum alpha-fetoprotein screening: promise not yet fulfilled.  


Measurement of alpha fetoprotein (AFP) levels in amniotic fluid has been used as a diagnostic tool for detection of neural tube defects (NTDs) in the fetus. AFP measurement in conjunction with ultrasonography yields a 90% NTD detection rate. The technique is recommended for use in pregnancies known to be at risk of NTDs and as a screening technique for use with 2nd-trimester amniocentesis. In recent years, maternal serum AFP assays have been used for NTD detection. The technique has promise as a diagnostic tool but is not recommended for routine maternal screening. Problems with maternal AFP screening are: 1) the large number of false positive results; 2) lack of general patient and physician education on the screening technique; 3) technical problems related to the assay; 4) inconsistency of assay results from 1 laboratory to another; and 5) the lack of established normal standards for the test. PMID:89812

Nadler, H L; Simpson, J L



Study to treat deadly form of thyroid cancer shows promise

A combination of therapies may prove to be a promising advance for the treatment of anaplastic thyroid cancer based on results of a phase I clinical trial. The collaborative study, published in the April 16 online issue of the Journal of Clinical Endocrinology & Metabolism, reports that combining paclitaxel chemotherapy with an experimental agent known as efatutazone was safe and well tolerated by patients. Organizations participating in the study were: the Mayo Clinic, the University of Pennsylvania Abramson Cancer Center, Eastern Virginia University, the Dana-Farber Cancer Institute, Ohio State University (home to the OSU Comprehensive Cancer Center), the University of Oregon Medical Center (home to the Knight Cancer Institute), the University of Colorado School of Medicine (home to the University of Colorado Cancer Center), Emory University Hospital (home of the Winship Cancer Institute), Weill Cornell Medical College, and Japanese pharmaceutical company, Daiichi Sankyo.


Genomic signatures and gene networking: challenges and promises  

PubMed Central

This is an editorial report of the supplement to BMC Genomics that includes 15 papers selected from the BIOCOMP'10 - The 2010 International Conference on Bioinformatics & Computational Biology as well as other sources with a focus on genomics studies. BIOCOMP'10 was held on July 12-15 in Las Vegas, Nevada. The congress covered a large variety of research areas, and genomics was one of the major focuses because of the fast development in this field. We set out to launch a supplement to BMC Genomics with manuscripts selected from this congress and invited submissions. With a rigorous peer review process, we selected 15 manuscripts that showed work in cutting-edge genomics fields and proposed innovative methodology. We hope this supplement presents the current computational and statistical challenges faced in genomics studies, and shows the enormous promises and opportunities in the genomic future.



Alternative variables in drug discovery: promises and challenges.  


A number of alternative variables have appeared in the medicinal chemistry literature trying to provide a more rigorous formulation of the guidelines proposed by Lipinski to exclude chemical entities with poor pharmacokinetic properties early in the discovery process. Typically, these variables combine the affinity towards the target with physicochemical properties of the ligand and are named efficiencies or ligand efficiencies. Several formulations have been defined and used by different laboratories with different degrees of success. A unified formulation, ligand efficiency indices, was proposed that included efficiency in two complementary variables (i.e., size and polarity) to map and monitor the drug-discovery process (AtlasCBS). The use of this formulation in combination with an extended multiparameter optimization is presented, with examples, as a promising methodology to optimize the drug-discovery process in the future. Future perspectives and challenges for this approach are also discussed. PMID:24649959

Abad-Zapatero, Cele; Champness, Edmund J; Segall, Matthew D



Capturing the Imagination: The Promise of the Webb Space Telescope  

NASA Astrophysics Data System (ADS)

The Webb Space Telescope will take us on a journey back to the beginning, enabling us to see the first galaxies, the birth of stars, the creation of planets, and the origins of galactic structure. News, education, and outreach activities led by the Space Telescope Science Institute Office of Public Outreach use the promise of Webb's scientific return and technical prowess to capture the imagination—inspiring and educating youth and adults about key science, technology, engineering, and mathematics concepts and the process of science itself. We highlight activities designed to introduce cutting-edge Webb science and technology to established audiences cultivated through a decade of Hubble-based Amazing Space, ViewSpace, HubbleSite, and NewsCenter products and services. Critical underlying components include a commitment to evaluation of audience needs and partnerships between scientists and educators.

Smith, D. A.; Livio, M.; Eisenhammer, B.; Kakadelis, S.; Villard, R.; Stiavelli, M.; Stockman, P.



The rise of the teleworker: false promises and responsive solutions  

Microsoft Academic Search

The purpose of this exploratory study was to gain a better understanding of how to provide learning opportunities to improve\\u000a teaching practices for the increasing numbers of academics who are choosing to work online from remote offices, sometimes\\u000a called e-academics, remote workers, or teleworkers. The objectives of the study were twofold: (1) to explore structures that\\u000a can encourage the improvement

Heather Kanuka; Kam Jugdev; Robert Heller; Dan West



Promising systemic immunotherapies in head and neck squamous cell carcinoma.  


Patients with head and neck squamous cell carcinoma (HNSCC) demonstrate poor survival and significant treatment morbidity with standard therapy. The immune profile in HNSCC, whether caused by carcinogen exposure or human papillomavirus (HPV), is notably immunosuppressive. Early clinical trials of immunotherapy in HNSCC were troubled by systemic toxicity or difficulties in local administration. Now, interest in immunotherapy has been revitalized by mechanistic insights into immune evasion by HNSCC, coupled to ongoing development of novel immunotherapies. This review will summarize immune escape mechanisms in HNSCC, namely downregulation of tumor antigen (TA) presentation, aberrant regulation of the signal transducer and activator of transcription (STAT) family, the immunosuppressive cytokine milieu, and dysregulation of immune effector cells. Therapeutic strategies hypothesized to specifically counter HNSCC immunosuppression will then be discussed. We will survey TA- targeted monoclonal antibodies (mAb), including the prototype cetuximab, as well as adjunctive strategies to enhance antibody-dependent cell-mediated cytotoxicity. We will review immunomodulation to restore STAT1/STAT3 activation balance. Examples of mAb therapy to block immunosuppressive cytokines, such as interleukin-6 or VEGF, will be provided. mAbs which release co-inhibitory T cell receptors such as CTLA-4 and PD-1, overexpressed in HNSCC, also hold therapeutic promise. Finally, we will describe principles for therapeutic vaccination in HPV-associated HNSCC, where non-host TAs such as viral oncoproteins represent ideal targets, and HPV-negative HNSCC, where p53 is a promising target. Insights into immunosuppression in HNSCC have elucidated mechanistic targets for immunotherapy. Rational clinical investigation may lead to effective stand alone or combinatorial treatment approaches. PMID:24126223

Gildener-Leapman, Neil; Ferris, Robert L; Bauman, Julie E



Identifying influential nodes in complex networks  

NASA Astrophysics Data System (ADS)

Identifying influential nodes that lead to faster and wider spreading in complex networks is of theoretical and practical significance. The degree centrality method is very simple but of little relevance. Global metrics such as betweenness centrality and closeness centrality can better identify influential nodes, but are incapable to be applied in large-scale networks due to the computational complexity. In order to design an effective ranking method, we proposed a semi-local centrality measure as a tradeoff between the low-relevant degree centrality and other time-consuming measures. We use the Susceptible-Infected-Recovered (SIR) model to evaluate the performance by using the spreading rate and the number of infected nodes. Simulations on four real networks show that our method can well identify influential nodes.

Chen, Duanbing; Lü, Linyuan; Shang, Ming-Sheng; Zhang, Yi-Cheng; Zhou, Tao



Flood Map Modernization: Program Strategy Shows Promise, but Challenges Remain.  

National Technical Information Service (NTIS)

Flood maps identify areas at greatest risk of flooding and provide the foundation for the National Flood Insurance Program (NFIP) managed by the Federal Emergency Management Agency (FEMA). The maps are used by (1) communities to establish minimum building...



Midwives' practices and beliefs about discharging clients from their practice.  


Discharging a client from a practice is a choice clinicians may need to make when conflicts arise that cannot be resolved. The legal and ethical considerations before discharging a client are presented. This preliminary survey of 111 certified nurse-midwives was conducted to determine their practices and beliefs about discharging clients. Most (83.7%) participants had discharged five or fewer clients from their practice throughout their careers, including 36.9% who had never discharged a client from their practice. In contrast, 77.5% of participants said that midwives should definitely discharge clients from their practice under some circumstances. Antepartum care was the most frequent period during which clients were discharged, and 59% of those discharged were for noncompliance with the therapeutic regimen, obnoxious or abusive behavior as subjectively identified by the midwife and her colleagues, or failure to keep appointments. When asked why they might not discharge a client from their practice, 60% identified empathy or sympathy for the client as the reason. When asked why they did not discharge clients in the past, 23 (21%) respondents selected "colleagues disagreed" as the reason. PMID:17826709

Schorn, Mavis N



Brief Questions to Identify Patients With Inadequate Health Literacy  

Microsoft Academic Search

Background and Objectives: No practical method for identifying patients with low heath literacy exists. We sought to develop screening questions for identifying patients with inadequate or marginal health literacy. Methods: Patients (n=332) at a VA preoperative clinic completed in-person interviews that in- cluded 16 health literacy screening questions on a 5-point Likert scale, followed by a validated health literacy measure,

Lisa D. Chew; Katharine A. Bradley; Edward J. Boyko



Identifying \\  

Microsoft Academic Search

The past decade has seen a remarkable evolution of sea-floor-based ice-draft profiling capabilities. Efforts have progressed from an original Beaufort Sea deployment of a single upward-looking acoustic echo sounder to the almost routine present-day positionings of special-purpose profiler units which operate in conjunction with adjacent current profiling and ice drift measurement instruments. These units allow detailed specification of draft statistics

D. B. Fissel; J. R. Marko; H. Melling



Cooperative testing of a positive personnel identifier  

SciTech Connect

HEDL has a requirement to ensure the identification of remote computer terminal operators on a real-time nuclear inventory data base. The integrity of this data base depends on input from authorized individuals. Thus, a key to developing such a system is the ability to positively identify people attempting access to the system. Small scale tests of the Identimat 2000T hand geometry unit with an adjusting alogrithm have suggested a promising solution. To prove operational suitability, HEDL, in cooperation with Sandia Laboratories, has designed a large scale test of the Identimat 2000T. Data gathering on error rates, reliability, maintainability, and user acceptance will determine if the Identimat 2000T is suitable for the HEDL application. If proven acceptable, use of the Identimat 2000T can be broadened to many general applications where security information, locations and systems are required.

O'Callaghan, P.B.; Grambihler, A.J.; Graham, D.K.; Bradley, R.G.



Evaluation of N,N-dialkylamides as promising process extractants  

NASA Astrophysics Data System (ADS)

Studies carried out at BARC, India on the development of new extractants for reprocessing of spent fuel suggested that while straight chain N,N-dihexyloctanamide (DHOA) is promising alternative to TBP for the reprocessing of irradiated uranium based fuels, branched chain N,N-di(2-ethylhexyl)isobutyramide (D2EHIBA) is suitable for the selective recovery of 233U from irradiated Th. In advanced fuel cycle scenarios, the coprocessing of U/Pu stream appears attractive particularly with respect to development of proliferation resistant technologies. DHOA extracted Pu(IV) more efficiently than TBP, both at trace-level concentration as well as under uranium/plutonium loading conditions. Uranium extraction behavior of DHOA was however, similar to that of TBP during the extraction cycle. Stripping behavior of U and Pu (without any reductant) was better for DHOA than that of TBP. It was observed during batch studies that whereas 99% Pu is stripped in four stages in case of DHOA, only 89% Pu is stripped in case of TBP under identical experimental conditions. DHOA offered better fission product decontamination than that of TBP. GANEX (Group ActiNide EXtraction) and ARTIST (Amide-based Radio-resources Treatment with Interim Storage of Transuranics) processes proposed for actinide partitioning use branched chain amides for the selective extraction of uranium from spent fuel feed solutions. The branched-alkyl monoamide (BAMA) proposed to be used in ARTIST process is N,N-di-(2-ethylhexyl)butyramide (D2EHBA). In this context, the extraction behavior of U(VI) and Pu(IV) were compared using D2EHIBA, TBP, and D2EHBA under similar concentration of nitric acid (0.5 — 6M) and of uranium (0-50g/L). These studies suggested that D2EHIBA is a promising extractant for selective extraction of uranium over plutonium in process streams. Similarly, D2EHIBA offered distinctly better decontamination of 233U over Th and fission products under THOREX feed conditions. The possibility of simultaneous stripping and precipitation of thorium (as oxalate) from loaded organic phase was explored using 0.05M oxalic acid. Ammonium diuranate (ADU) precipitation was performed on the oxalate supernatant for the recovery of uranium. Quantitative recovery (>99.9%) of Th as well as of U was achieved. Radiolytic studies suggested that irradiated DHOA and D2EHIBA behaved better with respect to fission product decontamination as compared to that of TBP.

Pathak, P. N.; Prabhu, D. R.; Kanekar, A. S.; Manchanda, V. K.



The social process of escalation: a promising focus for crisis management research  

PubMed Central

Background This study identifies a promising, new focus for the crisis management research in the health care domain. After reviewing the literature on health care crisis management, there seems to be a knowledge-gap regarding organisational change and adaption, especially when health care situations goes from normal, to non-normal, to pathological and further into a state of emergency or crisis. Discussion Based on studies of escalating situations in obstetric care it is suggested that two theoretical perspectives (contingency theory and the idea of failure as a result of incomplete interaction) tend to simplify the issue of escalation rather than attend to its complexities (including the various power relations among the stakeholders involved). However studying the process of escalation as inherently complex and social allows us to see the definition of a situation as normal or non-normal as an exercise of power in itself, rather than representing a putatively correct response to a particular emergency. Implications The concept of escalation, when treated this way, can help us further the analysis of clinical and institutional acts and competence. It can also turn our attention to some important elements in a class of social phenomenon, crises and emergencies, that so far have not received the attention they deserve. Focusing on organisational choreography, that interplay of potential factors such as power, professional identity, organisational accountability, and experience, is not only a promising focus for future naturalistic research but also for developing more pragmatic strategies that can enhance organisational coordination and response in complex events.



Variations in tobacco control in National Dental PBRN practices: the role of patient and practice factors.  


We engaged dental practices enrolled in The National Dental Practice-Based Research Network to quantify tobacco screening (ASK) and advising (ADVISE); and to identify patient and practice -characteristics associated with tobacco control. Dental practices (N = 190) distributed patient surveys that measured ASK and ADVISE. Twenty-nine percent of patients were ASKED about tobacco use during visit, 20% were identified as tobacco users, and 41% reported being ADVISED. Accounting for clustering of patients within practices, younger age and male gender were positively associated with ASK and ADVISE. Adjusting for patient age and gender, a higher proportion of non-whites in the practice, preventive services and proportion on public assistance were positively associated with ASK. Proportion of tobacco users in the practice and offering other preventive services were more strongly associated with ASK and ADVISE than other practice characteristics. Understanding variations in performance is an important step toward designing strategies for improving tobacco control in dentistry. PMID:24164227

Ray, Midge N; Allison, Jeroan J; Coley, Heather L; Williams, Jessica H; Kohler, Connie; Gilbert, Gregg H; Richman, Joshua S; Kiefe, Catarina I; Sadasivam, Rajani S; Houston, Thomas K