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Sample records for im fokus des

  1. Die Gasultrazentrifuge als mediale Projektion des Kalten Krieges

    NASA Astrophysics Data System (ADS)

    Helmbold, Bernd

    Studien der letzten Dekaden nach der Wiedervereinigung von BRD und DDR erweitern die Perspektive der Wissenschaftsgeschichte vom Fokus des Big Science und der technisch-militärisch-industriellen Auseinandersetzung zwischen den zwei Blöcken zu einer globalen Transformation im Konflikt der Supermächte geprägt durch lokale und auch interne Ausformungen.

  2. Was leistet ein Sportler? Kraft, Leistung und Energie im Muskel

    NASA Astrophysics Data System (ADS)

    Thaller, Sigrid; Mathelitsch, Leopold

    2006-01-01

    Der Leistungsbegriff ist im Sport weiter gefasst als in der Physik. In beiden Fällen liegt der Fokus jedoch auf einer pro Zeiteinheit erfolgten Energieumsetzung. Allerdings gibt die rein physikalische Leistung nicht immer Auskunft über den Energieumsatz der Muskeln. Die Muskelkraft hängt von der Kontraktionsgeschwindigkeit des Muskels ab. Ein Muskel verhält sich also anders als eine Feder. Für den Hochleistungssport müssen die Energieumsätze der Muskeln durch spezielle Trainings- und Nahrungsprogramme optimiert werden.

  3. Expertise bewerben und finden im Social Semantic Web

    NASA Astrophysics Data System (ADS)

    Polleres, Axel; Mochol, Malgorzata

    Im vorliegenden Beitrag diskutieren wir Rahmenbedingungen zur Kombination, Wiederverwendung und Erweiterung bestehender RDFVokabulare im Social Semantic Web. Hierbei konzentrieren wir uns auf das Anwendungsszenario des Auffindens und Bewerbens von Experten im Web oder Intranet. Wir präsentieren, wie RDF-Vokabulare einerseits und de facto Standardformate andererseits, die von täglich verwendeten Applikationen benutzt werden (z. B. vCard, iCal oder Dublin Core), kombiniert werden können, um konkrete Anwendungsfälle der Expertensuche und zum Management von Expertise zu lösen. Unser Fokus liegt darauf aufzuzeigen, dass für praktische Anwendungsszenarien nicht notwendigerweise neue Ontologien entwickelt werden müssen, sondern der Schlüssel vielmehr in der Integration von bestehenden, weit verbreiteten und sich ergänzenden Formaten zu einem kohärenten Netzwerk von Ontologien liegt. Dieser Ansatz garantiert sowohl direkte Anwendbarkeit von als auch niedrige Einstiegsbarrieren in Semantic Web-Technologien sowie einfache Integrierbarkeit in bestehende Applikationen. Die im Web verfügbaren und verwendeten RDFFormate decken zwar einen großen Bereich der Aspekte zur Beschreibung von Personen und Expertisen ab, zeigen aber auch signifikante Überlappungen. Bisher gibt es wenig systematische Ansätze, um diese Vokabulare zu verbinden, sei es in Form von allgemeingültigen Praktiken, die definieren, wann welches Format zu benutzen ist, oder in Form von Regeln, die Überlappungen zwischen einzelnen Formaten formalisieren. Der vorliegende Artikel analysiert, wie bestehende Formate zur Beschreibung von Personen, Organisationen und deren Expertise kombiniert und, wo nötig, erweitert werden können. Darüber hinaus diskutieren wir Regelsprachen zur Beschreibung von Formatüberlappungen sowie deren praktische Verwendbarkeit zur Erstellung eines Ontologie-Netzwerks zur Beschreibung von Experten.

  4. Charakterisierung von Sulfotransferasen im Gastrointestinaltrakt von Mensch und Ratte und Aktivierung von Promutagenen in V79-Zellen, die eine intestinale Form (1B1) des Menschen und der Ratte exprimieren

    NASA Astrophysics Data System (ADS)

    Teubner, Wera

    2001-05-01

    Die Ausstattung der gastrointestinalen Mukosa des Menschen und der Ratte mit Sulfotransferasen wurde mit Hilfe von Immunodetektion und Enzymaktivitätsmessungen untersucht. In Proben aus Colon und Rektum von 39 Personen wurden die Formen h1A1, h1A3 und h1B1 identifiziert, wobei in einer weiteren Probe, die als einzige von einem an Colitis Ulcerosa erkrankten Patienten stammte, keine Sulfotransferasen nachgewiesen werden konnten. Bei der Immunblot-Analyse war das Expressionsmuster der einzelnen Formen in allen Proben ähnlich. In wenigen Proben waren die relativen Signalintensitäten der h1A1 und der h1B1 um die Hälfte erniedrigt. Der Gehalt von SULT an zytosolischem Protein zeigte einen bis zu 8 - 10fachen Unterschied, er betrug jedoch bei zwei Dritteln der Proben zwischen 0,15 und 0,3 (h1A1 und h1A3) bzw. 0,6 und 0,8 Promille (h1B1). Die Variation konnte nicht auf Alter, Geschlecht oder Krankheitsbild der Patienten zurückgeführt werden. Auch der für die allelischen Varianten der h1A1 beschriebene Effekt auf die Enzymaktiviät bzw. Stabilität konnte in der Menge an immunreaktivem Protein nicht in diesem Ausma detektiert werden. Die Allelhäufigkeit von h1A1*R und h1A1*H war gegenüber der gesunden Bevölkerung nicht verändert. In den sieben Proben aus dem Dünndarm (Coecum, viermal Ileum, Jejunum) konnten zusätzlich die Formen h1E1 und h2A1 identifiziert werden. Ein möglicherweise der Form h1C1 entsprechendes Protein wurde im Magen detektiert. Im Vergleich zum Menschen war die Expression in der Ratte stärker auf die Leber konzentriert. Während beim Menschen in allen untersuchten Abschnitten Sulfotransferasen in Mengen detektiert wurden, die in zwei Fällen (h1B1 und h1A3) sogar den Gehalt in der Leber überstiegen, beschränkte sich die Expression in der Ratte auf im Vergleich zur Leber geringe Mengen im Magen und Dickdarm. Nachgewiesen wurden die r1B1, r1A1 sowie eine nicht identifizierte Form von 35kD, bei der es sich vermutlich um die r1C2 handelt. Im

  5. Implantate im Mittelohrbereich - Teil 2 (Ergänzungen 2007)

    NASA Astrophysics Data System (ADS)

    Stieve, M.; Lenarz, Thomas

    In Deutschland leben ca. 12 Millionen Menschen, die an einer ein- oder beidseitigen Schwerhörigkeit leiden. Diese kann angeboren oder im Laufe des Lebens erworben sein. Klinisch und therapeutisch wichtig ist die Unterscheidung hinsichtlich des Schädigungsortes im Bereich des Mittelohres, d. h. eine Schalleitungsschwerhörigkeit, oder im Bereich des Innenohres, d. h. eine Schallempfindungsschwerhörigkeit, wobei hier der Schädigungsort auch am Hörnerven oder in den zentralen Hörabschnitten liegen kann. Therapeutisch lassen sich sowohl Schwerhörigkeiten im Bereich des Mittelohres als auch im Innenohr und sogar im Hirnstammbereich (Hirnstammimplantat) behandeln. 1,9 Millionen Schwerhörige haben eine Erkrankung im Mittelohrbereich, d. h. der Schall kann nur ungenügend auf das Innenohr übertragen werden. Die Ursache besteht meist in einer chronischen Mittelohrentzündung, die zu einer Zerstörung des Trommelfells und der Gehörknöchelchenkette geführt haben. Therapeutisch und damit als Prinzip der operativen Hörverbesserung steht primär der Verschluß des Trommelfells oder eine Rekonstruktion der Gehörknöchelchen. Mittelohroperationen werden mikrochirurgisch unter dem Operationsmikroskop durchgeführt, wobei zunächst durch eine sanierende Operation der Entzündungsprozeß entfernt wird und nach einer Ausheilungszeit die Gehörknöchelchenkette durch künstliche Prothesen rekonstruiert werden kann.

  6. Modellierung von Anwenderverhalten im Social Semantic Web

    NASA Astrophysics Data System (ADS)

    Ulbrich, Armin; Höfler, Patrick; Lindstaedt, Stefanie

    Ziel dieses Kapitels ist es, gemeinsame Verwendungsszenarien des Semantic Web und des Social Web zu identifizieren und zu benennen. Dabei wird ein Teilaspekt des Themengebiets im Detail betrachtet: die Nutzung von Services, die Beobachtungen des Verhaltens von Anwendern analysieren, um daraus maschinell interpretierbare Informationen zu erhalten und diese als Modelle zu organisieren. Es werden zunächst einige Eigenschaften und Unterscheidungsmerkmale von Anwenderverhalten und organisierten Modellen dargestellt. Anschließend wird der mögliche wechselseitige Nutzen von Anwenderverhalten und Modellen diskutiert. Den Abschluss bildet eine Betrachtung einiger exemplarischer Software-Services, die heute schon verwendet werden, um Anwenderverhalten in Modelle überzuführen.

  7. Charakterisierung von Sulfotransferasen im Gastrointestinaltrakt von Mensch und Ratte und Aktivierung von Promutagenen in V79-Zellen, die eine intestinale Form (1B1) des Menschen und der Ratte exprimieren

    NASA Astrophysics Data System (ADS)

    Teubner, Wera

    2001-05-01

    Die Ausstattung der gastrointestinalen Mukosa des Menschen und der Ratte mit Sulfotransferasen wurde mit Hilfe von Immunodetektion und Enzymaktivitätsmessungen untersucht. In Proben aus Colon und Rektum von 39 Personen wurden die Formen h1A1, h1A3 und h1B1 identifiziert, wobei in einer weiteren Probe, die als einzige von einem an Colitis Ulcerosa erkrankten Patienten stammte, keine Sulfotransferasen nachgewiesen werden konnten. Bei der Immunblot-Analyse war das Expressionsmuster der einzelnen Formen in allen Proben ähnlich. In wenigen Proben waren die relativen Signalintensitäten der h1A1 und der h1B1 um die Hälfte erniedrigt. Der Gehalt von SULT an zytosolischem Protein zeigte einen bis zu 8 - 10fachen Unterschied, er betrug jedoch bei zwei Dritteln der Proben zwischen 0,15 und 0,3 (h1A1 und h1A3) bzw. 0,6 und 0,8 Promille (h1B1). Die Variation konnte nicht auf Alter, Geschlecht oder Krankheitsbild der Patienten zurückgeführt werden. Auch der für die allelischen Varianten der h1A1 beschriebene Effekt auf die Enzymaktiviät bzw. Stabilität konnte in der Menge an immunreaktivem Protein nicht in diesem Ausma detektiert werden. Die Allelhäufigkeit von h1A1*R und h1A1*H war gegenüber der gesunden Bevölkerung nicht verändert. In den sieben Proben aus dem Dünndarm (Coecum, viermal Ileum, Jejunum) konnten zusätzlich die Formen h1E1 und h2A1 identifiziert werden. Ein möglicherweise der Form h1C1 entsprechendes Protein wurde im Magen detektiert. Im Vergleich zum Menschen war die Expression in der Ratte stärker auf die Leber konzentriert. Während beim Menschen in allen untersuchten Abschnitten Sulfotransferasen in Mengen detektiert wurden, die in zwei Fällen (h1B1 und h1A3) sogar den Gehalt in der Leber überstiegen, beschränkte sich die Expression in der Ratte auf im Vergleich zur Leber geringe Mengen im Magen und Dickdarm. Nachgewiesen wurden die r1B1, r1A1 sowie eine nicht identifizierte Form von 35kD, bei der es sich vermutlich um die r1C2 handelt. Im

  8. Physikdidaktik Ein Rastertunnelmikroskop im Selbstbau

    NASA Astrophysics Data System (ADS)

    Panzer, Oliver; Fuchs, Harald

    2004-09-01

    Seit Anfang der achtziger Jahre macht das Rastertunnelmikroskop die Untersuchung von Oberflächen mit atomarer Genauigkeit möglich. Engagierte Schüler und Studienanfänger haben nun die Möglichkeit, sich selbst ein Bild des Sub-Mikrokosmos zu machen: die Universität Münster präsentiert im Internet eine komplette Anleitung für den Aufbau eines einfachen Rastertunnelmikroskops für unter 1000 .

  9. IMS - MS Data Extractor

    Energy Science and Technology Software Center (ESTSC)

    2015-10-20

    An automated drift time extraction and computed associated collision cross section software tool for small molecule analysis with ion mobility spectrometry-mass spectrometry (IMS-MS). The software automatically extracts drift times and computes associated collision cross sections for small molecules analyzed using ion mobility spectrometry-mass spectrometry (IMS-MS) based on a target list of expected ions provided by the user.

  10. Instant Messaging: IM Online! RU?

    ERIC Educational Resources Information Center

    Farmer, Robert

    2005-01-01

    This article discusses the technology of instant messaging (IM), a relatively simple form of communication. It is also--by its very nature--a collaborative communications tool. This collaborative nature is what makes IM ideal for educational and learning environments. With IM playing such a large role in the communication, interactivity, and…

  11. Der Physik-Nobelpreis vor 100 Jahren Die Entdeckung des trägen Gases

    NASA Astrophysics Data System (ADS)

    Jacobi, Manfred

    2004-11-01

    Im Jahr 1904 erhielt der britische Physiker Lord Rayleigh (John William Strutt, 1842 bis 1919) den Nobelpreis für seine Untersuchungen über die Dichte von Gasen und die Entdeckung des Edelgases Argon.

  12. Vernetzung im Kfz

    NASA Astrophysics Data System (ADS)

    Reif, Konrad

    Elektrische und elektronische Systeme im Kfz sind vielfach nicht voneinander unabhängig, sondern beeinflussen und ergänzen sich gegenseitig. Deshalb wurden schon bei den frühen Einspritz- und Zündsystemen Signalleitungen eingesetzt, um eine einfache Kommunikation zwischen diesen beiden Systemen zu ermöglichen. Die zunehmende Anzahl elektronischer Systeme erhöhte jedoch rasch den Bedarf und die Vielfalt an auszutauschenden Informationen. Die Anzahl der hierzu erforderlichen Signalleitungen und Stecker anschlüsse stiegen gleichermaßen, so dass die bis dahin angewandte Technik an ihre Grenzen stieß.

  13. IMS applications analysis

    SciTech Connect

    RODACY,PHILIP J.; REBER,STEPHEN D.; SIMONSON,ROBERT J.; HANCE,BRADLEY G.

    2000-03-01

    This report examines the market potential of a miniature, hand-held Ion Mobility Spectrometer. Military and civilian markets are discussed, as well as applications in a variety of diverse fields. The strengths and weaknesses of competing technologies are discussed. An extensive Ion Mobility Spectrometry (IMS) bibliography is included. The conclusions drawn from this study are: (1) There are a number of competing technologies that are capable of detecting explosives, drugs, biological, or chemical agents. The IMS system currently represents the best available compromise regarding sensitivity, specificity, and portability. (2) The military market is not as large as the commercial market, but the military services are more likely to invest R and D funds in the system. (3) Military applications should be addressed before commercial applications are addressed. (4) There is potentially a large commercial market for rugged, hand-held Ion Mobility Spectrometer systems. Commercial users typically do not invest R and D funds in this type of equipment rather, they wait for off-the-shelf availability.

  14. Energieeffizienz im Rechenzentrum

    NASA Astrophysics Data System (ADS)

    von Hintemann, Ralph; Skurk, Holger

    In den stark automatisierten, arbeitsteiligen Wirtschaftsystemen der Industrienationen ist die eine effiziente und zuverlässige zentrale Informationstechnik (IT) der Unternehmen entscheidend für den Geschäftserfolg. Immer mehr Unternehmensabläufe werden durch die IT unterstützt. Vielfach ist es sogar nur noch durch die umfassende IT-Unterstützung der Geschäftsprozesse möglich, im globalen Wettbewerb erfolgreich zu sein. Die installierte Rechenleistung in modernen Unternehmen steigt dabei ständig an. Neue und verbesserte Anwendungen und Programm-Features erfordern leistungsfähige Server. In den Rechenzentren kleiner und mittlerer Unternehmen sind heute Rechenleistungen installiert, die vor wenigen Jahren ausschließlich einigen Großunternehmen vorbehalten waren. Diese im Grundsatz positive Entwicklung kann aber auch zu hohen Strom- und Kühlleistungen in Rechenzentren führen. Damit stellen sich neue Herausforderungen an die Planung, Ausführung und den Betrieb einer IT-Infrastruktur.

  15. Summation of IMS Volume Frequencies.

    ERIC Educational Resources Information Center

    Gordillo, Frank

    A computer program designed to produce summary information on the data processing volume of the Southwest Regional Laboratory's (SWRL) Instructional Management System (IMS) is described. Written in FORTRAN IV for use on an IBM 360 Model 91, the program sorts IMS input data on the basis of run identifier and on the basis of classroom identification…

  16. Wiener Geologen im Spiegel des Geologenarchivs. Kober - Kieslinger - Ampferer

    NASA Astrophysics Data System (ADS)

    Seibold, I.; Seibold, E.

    2001-05-01

    The bulk of the correspondence in the Geologenarchiv comes in two major groups:a) letters relating mainly to professional matters and b) letters containing predominantly personal communication. This will be demonstrated by material relating to the three above mentioned Viennese Geologists: Leopold Kober's letter to Wilhelm Salomon-Calvi and the correspondence between Alois Kieslinger and Eugen Wegmann are mainly professional, whereas Otto Ampferer's letters to the Bavarian glaciologist Edith Ebers are a documentation of personal friendship.

  17. Des Moines.

    ERIC Educational Resources Information Center

    Gore, Deborah, Ed.

    1988-01-01

    This document, intended for elementary students, contains articles and activities designed to acquaint young people with the history of Des Moines, Iowa. The articles are short, and new or difficult words are highlighted and defined for young readers. "The Raccoon River Indian Agency" discusses the archeological exploration of the indian…

  18. Einfluss des Internets auf das Informations-, Einkaufs- und Verkehrsverhalten

    NASA Astrophysics Data System (ADS)

    Nerlich, Mark R.; Schiffner, Felix; Vogt, Walter

    Mit Daten aus eigenen Erhebungen können das einkaufsbezogene Informations- und Einkaufsverhalten im Zusammenhang mit den verkehrlichen Aspekten (Distanzen, Verkehrsmittel, Wegekopplungen) dargestellt werden. Die Differenzierung in die drei Produktkategorien des täglichen, mittelfristigen und des langfristigen Bedarfs berücksichtigt in erster Linie die Wertigkeit eines Gutes, die seine Erwerbshäufigkeit unmittelbar bestimmt. Der Einsatz moderner IKT wie das Internet eröffnet dem Endverbraucher neue Möglichkeiten bei Information und Einkauf. Die verkehrliche Relevanz von Online-Shopping wird deutlich, wenn man berücksichtigt, dass im Mittel rund 17% aller Online-Einkäufe, die die Probanden durchgeführt haben, Einkäufe in Ladengeschäften ersetzen. Dies gilt in verstärktem Maße für Online-Informationen: etwa die Hälfte hätte alternativ im stationären Einzelhandel stattgefunden. Da der Erwerb von Gütern des täglichen Bedarfs häufig nahräumlich und in relevantem Anteil nicht-motorisiert erfolgen kann, sind in diesem Segment - im Gegensatz zum mittel- und langfristigen Bedarf - nur geringe Substitutionseffekte zu beobachten.

  19. Advanced Interval Management (IM) Concepts of Operations

    NASA Technical Reports Server (NTRS)

    Barmore, Bryan E.; Ahmad, Nash'at N.; Underwood, Matthew C.

    2014-01-01

    This document provides a high-level description of several advanced IM operations that NASA is considering for future research and development. It covers two versions of IM-CSPO and IM with Wake Mitigation. These are preliminary descriptions to support an initial benefits analysis

  20. 23 CFR 500.111 - IMS.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false IMS. 500.111 Section 500.111 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRANSPORTATION INFRASTRUCTURE MANAGEMENT MANAGEMENT AND MONITORING SYSTEMS Management Systems § 500.111 IMS. An effective IMS for intermodal facilities and systems...

  1. 23 CFR 500.111 - IMS.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false IMS. 500.111 Section 500.111 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRANSPORTATION INFRASTRUCTURE MANAGEMENT MANAGEMENT AND MONITORING SYSTEMS Management Systems § 500.111 IMS. An effective IMS for intermodal facilities and systems...

  2. 23 CFR 500.111 - IMS.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false IMS. 500.111 Section 500.111 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRANSPORTATION INFRASTRUCTURE MANAGEMENT MANAGEMENT AND MONITORING SYSTEMS Management Systems § 500.111 IMS. An effective IMS for intermodal facilities and systems...

  3. 23 CFR 500.111 - IMS.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false IMS. 500.111 Section 500.111 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRANSPORTATION INFRASTRUCTURE MANAGEMENT MANAGEMENT AND MONITORING SYSTEMS Management Systems § 500.111 IMS. An effective IMS for intermodal facilities and systems...

  4. 23 CFR 500.111 - IMS.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false IMS. 500.111 Section 500.111 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRANSPORTATION INFRASTRUCTURE MANAGEMENT MANAGEMENT AND MONITORING SYSTEMS Management Systems § 500.111 IMS. An effective IMS for intermodal facilities and systems...

  5. Sonderverfahren des Spritzgießens

    NASA Astrophysics Data System (ADS)

    Michaeli, Walther; Lettowsky, Christoph

    Das Spritzgießen ist neben der Extrusion das wichtigste Verarbeitungsverfahren für Kunststoffe [1]. Das Verfahren hat sich seit seinen Ursprüngen Ende des 19. Jahrhunderts bis heute stetig weiterentwickelt [2]. In neuerer Zeit steigt die Anzahl komplexer Anwendungen, die die gezielte Kombination verschiedener Funktionalitäten in einem Formteil erfordern. Das Standard-Spritzgießen kann diese Anforderungen immer weniger befriedigen. Daher gewinnen die Sonderverfahren des Spritzgießens zunehmend an Bedeutung [3]. Ihre Anzahl beträgt inzwischen über 100. Die Aufgabe des Anwenders ist es, aus der Vielzahl der möglichen Verfahren, ein anforderungsgerechtes auszuwählen, das sowohl unter technischen wie wirtschaftlichen Gesichtspunkten die optimale Lösung darstellt. Dies setzt die ständige Auseinandersetzung mit Entwicklungstendenzen im Bereich der Spritzgießtechnologie voraus. Daher soll im folgenden Abschnitt ein Überblick über die wichtigsten Spritzgieß-Sonderverfahren gegeben werden.

  6. Grundlegende Steuerungsverfahren im heterogenen Logistiknetz mit Kanban

    NASA Astrophysics Data System (ADS)

    Dickmann, Eva; Dickmann, Philipp; Lödding, Hermann; Möller, Niklas; Rücker, Thomas; Schneider, Herfried M.; Zäh, Michael F.

    In vielen Unternehmen werden heterogene (verschiedene) Steuerungen in einem abgestimmten Konzept kombiniert. Je nach Anwendungsfall und Rahmenbedingungen werden Kombinationen allgemein bekannter Steuerungen oder Steuerungsvarianten gemischt eingesetzt, um eine optimale Steuerung für unterschiedliche Fälle zu erreichen. Hierbei stehen neben den bekannten und weit verbreiteten Methoden, wie Material Requirements Planning (MRP) oder Kanban, auch weniger bekannte oder neue Methoden zur Auswahl, wie die Produktionssteuerung mit dezentraler, bestandsorientierter Fertigungsregelung (DBF). Kanban ist ein simples und effizientes Steuerungskonzept, das in der klassischen Form für spezifische einfache Anwendungsfälle umsetzbar ist. Hochentwickelte Steuerungsalgorithmen können helfen, komplexe Abläufe optimal abzubilden. Mit einer grundlegenden Vereinfachung der Abläufe kann allerdings in vielen Fällen ein wesentlich stärkerer und umfassender Verbesserungseffekt erzielt werden. Die wesentliche Fragestellung sollte folglich lauten: Warum ist der Ablauf nicht mit einer einfachen Steuerung wie Kanban abzubilden? Um die Vorteile des Konzepts auch in untypischen Bereichen anwenden zu können, sind jedoch verschiedene Varianten oder Kanban-ähnliche Steuerungsmethoden entstanden. Darüber hinaus sind in der Praxis hybride Steuerungen im Einsatz, welche so kombiniert werden, dass die Zusammensetzung anspruchsvolle Eigenschaftsbilder noch exakt abbildet. In der Praxis basieren die Steuerungsentscheidungen nur zu einem kleinen Teil auf den eigentlichen Steuerungsalgorithmen, wie sie uns das MRP-System zur Verfügung stellt. Moderne Steuerungswelten" schließen alle relevanten Informationsquellen in eine heterogene Entscheidungsmatrix mit ein. Letztlich zählt nicht, ob die Entscheidung auf den Informationen aus dem MRP-System oder auf Softfacts basierend getroffen wurde, sondern nur, ob die Entscheidung erfolgreich war.

  7. Berechnung verkehrlicher Substitutionseffekte im Personenverkehr bei Online-Shopping

    NASA Astrophysics Data System (ADS)

    Nerlich, Mark R.; Schiffner, Felix; Vogt, Walter; Rauh, Jürgen; Breidenbach, Petra

    Für Güter des täglichen, mittelfristigen und langfristigen Bedarfs sowie für das Beispiel Baumarktartikel wird das Potenzial für Personenverkehrsaufwand von Einkaufsaktivtäten quantitativ abgeschätzt. Die entwickelten Algorithmen behandeln die einkaufsvorbereitende Information und den eigentlichen Einkauf, d.h. den Erwerb eines Gutes, separat. Informationsaktivitäten haben insbesondere bei höherwertigen Gütern einen hohen Stellenwert und damit auch verkehrliche Relevanz. Wie Berechnungen zeigen, spart Online-Shopping Informations- und Einkaufsverkehrsaufwand im Pkw-Verkehr ein. Die notwendigen Eingangsdaten wie differenzierte Informations- und Einkaufshäufigkeiten sowie verkehrliche Parameter zu Verkehrsmittelwahl, Entfernungen und Wegekopplungen wurden aus eigenen Erhebungen gewonnen.

  8. Analysis of IMS spectra using neural networks

    SciTech Connect

    Bell, S.E.

    1992-09-01

    Ion mobility spectrometry (IMS) has been used for over 20 years, and IMS coupled to gas chromatography (GC/IMS) has been used for over 10 years. There still is no systematic approach to IMS spectral interpretation such as exists for mass spectrometry and infrared spectrometry. Neural networks, a form of adaptive pattern recognition, were examined as a method of data reduction for IMS and GC/IMS. A wide variety of volatile organics were analyzed using IMS and GC/IMS and submitted to different networks for identification. Several different networks and data preprocessing algorithms were studied. A network was linked to a simple rule-based expert system and analyzed. The expert system was used to filter out false positive identifications made by the network using retention indices. The various network configurations were compared to other pattern recognition techniques, including human experts. The network performance was comparable to human experts, but responded much faster. Preliminary comparison of the network to other pattern recognition showed comparable performance. Linkage of the network output to the rule-based retention index system yielded the best performance.

  9. Analysis of IMS spectra using neural networks

    SciTech Connect

    Bell, S.E.

    1992-01-01

    Ion mobility spectrometry (IMS) has been used for over 20 years, and IMS coupled to gas chromatography (GC/IMS) has been used for over 10 years. There still is no systematic approach to IMS spectral interpretation such as exists for mass spectrometry and infrared spectrometry. Neural networks, a form of adaptive pattern recognition, were examined as a method of data reduction for IMS and GC/IMS. A wide variety of volatile organics were analyzed using IMS and GC/IMS and submitted to different networks for identification. Several different networks and data preprocessing algorithms were studied. A network was linked to a simple rule-based expert system and analyzed. The expert system was used to filter out false positive identifications made by the network using retention indices. The various network configurations were compared to other pattern recognition techniques, including human experts. The network performance was comparable to human experts, but responded much faster. Preliminary comparison of the network to other pattern recognition showed comparable performance. Linkage of the network output to the rule-based retention index system yielded the best performance.

  10. GEOSPATIAL IT/IM QA CHECKLIST

    EPA Science Inventory

    Quality assurance (QA) of information technology (IT) and Information Management (IM) systems help to ensure that the end product is of known quality and integrity. As the complexity of IT & IM processes increase, so does the need for regular QA evaluation.

    The areas revi...

  11. Zeit im Wandel der Zeit.

    NASA Astrophysics Data System (ADS)

    Aichelburg, P. C.

    Contents: Einleitung(P. C. Aichelburg). 1. Über Zeit, Bewegung und Veränderung (Aristoteles). 2. Ewigkeit und Zeit (Plotin). 3. Was ist die Zeit? (Augustinus). 4. Von der Zeit (Immanuel Kant). 5. Newtons Ansichten über Zeit, Raum und Bewegung (Ernst Mach). 6. Über die mechanische Erklärung irreversibler Vorgänge (Ludwig Boltzmann). 7. Das Maß der Zeit (Henri Poincaré). 8. Dauer und Intuition (Henri Bergson). 9. Die Geschichte des Unendlichkeitsproblems (Bertrand Russell). 10. Raum und Zeit (Hermann Minkowski). 11. Der Unterschied von Zeit und Raum (Hans Reichenbach). 12. Newtonscher und Bergsonscher Zeitbegriff (Norbert Wiener). 13. Die Bildung des Zeitbegriffs beim Kinde (JeanPiaget).14. Eine Bemerkung über die Beziehungen zwischen Relativitätstheorie und der idealistischen Philosophie (Kurt Gödel). 15. Der zweite Hauptsatz und der Unterschied von Vergangenheit und Zukunft (Carl Friedrich v. Weizsäcker). 16. Zeit als physikalischer Begriff (Friedrich Hund). 17. Zeitmessung und Zeitbegriff in der Astronomie (Otto Heckmann). 18. Kann die Zeit rückwärts gehen? (Martin Gardner). 19. Zeit und Zeiten (Ilya Prigogine, Isabelle Stengers). 20. Zeit als dynamische Größe in der Relativitätstheorie (P. C. Aichelburg).

  12. Ion Mobility Spectrometry (IMS) and Mass Spectrometry

    SciTech Connect

    Shvartsburg, Alexandre A.

    2010-04-20

    In a media of finite viscosity, the Coulomb force of external electric field moves ions with some terminal speed. This dynamics is controlled by “mobility” - a property of the interaction potential between ions and media molecules. This fact has been used to separate and characterize gas-phase ions in various modes of ion mobility spectrometry (IMS) developed since 1970. Commercial IMS devices were introduced in 1980-s for field detection of volatile traces such as explosives and chemical warfare agents. Coupling to soft-ionization sources, mass spectrometry (MS), and chromatographic methods in 1990-s had allowed IMS to handle complex samples, enabling new applications in biological and environmental analyses, nanoscience, and other areas. Since 2003, the introduction of commercial systems by major instrument vendors started bringing the IMS/MS capability to broad user community. The other major development of last decade has been the differential IMS or “field asymmetric waveform IMS” (FAIMS) that employs asymmetric time-dependent electric field to sort ions not by mobility itself, but by the difference between its values in strong and weak electric fields. Coupling of FAIMS to conventional IMS and stacking of conventional IMS stages have enabled two-dimensional separations that dramatically expand the power of ion mobility methods.

  13. I'm a Map, I'm a Green Tree

    ERIC Educational Resources Information Center

    Anderson, Daniel

    2010-01-01

    I'm talking about the ways we represent ourselves and our world. I've put some thoughts on the topic together here--a gathering that enacts new media creating and takes up conceptual layers like metaphors, models, and composing. The primary sources are videos from the Get a Mac campaign, aka I'm a Mac; I'm a PC ads. Posthuman concepts blending…

  14. The pinhole interface for IMS/MS

    NASA Technical Reports Server (NTRS)

    Spangler, Glenn E.

    1995-01-01

    An important supplementary technique for ion mobility spectrometry (IMS) is mass spectrometry (MS). A mass spectrometer coupled to an ion mobility spectrometer (IMS/MS) can provide significant information on the composition of the ions contributing to an ion mobility peak. On the other hand, the interpretation of IMS/MS results requires knowledge of processes which can occur at the pinhole interface. When the ion composition is a mixture of ion clusters, the observed cluster distribution may not be an accurate representation of the ion clusters in the IMS. Depending on the buffer gas, lower clusters can form by equilibrating with reduced concentrations in the continuum regime of the expansion and larger clusters can form by collisional stabilization in the cooled jet stream. Besides water, nitrogen molecules can also add to the ion clusters. Even though nitrogen is non-polar, this addition is made possible by an ion-induced dipole interaction between the ion and molecule.

  15. IM Based Speed Servodrive with Luenberger Observer

    NASA Astrophysics Data System (ADS)

    Gacho, Juraj; Žalman, Milan

    2010-05-01

    The article concerns observing states of the Induction Motor (IM) using a Luenberger observer in the speed servo drive. The movement of the motor and observer roots is analyzed for a variable speed. Following the analysis, a new method for gain evaluation of the IM magnetic flux observer is presented. This structure is extended by including an adaptive speed observer. The functionality of the presented method is proved in simulations using MATLAB Simulink.

  16. Ein Entscheidungsmodell zur Weitergabe persönlicher Daten im Internet

    NASA Astrophysics Data System (ADS)

    Treiblmaier, Horst

    In den vergangenen zwei Jahrzehnten wandelte sich das Internet von einer Spielwiese für technikbegeisterte Computerspezialisten zu einem vielseitig einsetzbaren weltweiten Netzwerk für Privatpersonen und Unternehmen. Maßgeblichen Anteil daran besaß die rasante Entwicklung des World Wide Web (WWW), das, durch die Möglichkeit multimediale Inhalte zu vermitteln, für einen großen Teil der Bevölkerung industrialisierter Länder zu einem wesentlichen Bestandteil des täglichen Lebens wurde. Dass diese Entwicklung noch lange nicht abgeschlossen ist, zeigt die derzeitige Diskussion zum Thema Web 2.0 bzw. 3.0. Waren es in den letzten Jahren die hohen Umsatzzuwächse im E-Commerce und multimedial gestaltete Webseiten in Kombination mit aufwändigen Applikationen, die für ständig steigende Nutzerzahlen im World Wide Web sorgten, so wird dieser Innovationsschub nunmehr durch eine Vielzahl von Anwendungen fortgesetzt, die sich durch die zunehmende Vernetzung der Nutzer untereinander auszeichnen.

  17. Data-Mining für die Angebotsoptimierung im Handel

    NASA Astrophysics Data System (ADS)

    Garcke, Jochen; Griebel, Michael; Thess, Michael

    Der Handel ist weltweit durch gravierenden Wettbewerbsdruck gekennzeichnet. Deutschland gilt im Einzelhandel sogar als der wettbewerbsintensivste Markt der Welt. Um in diesem Wettbewerb zu bestehen, vertrauen die meisten Händler auf extensive Formen ungezielten Massenmarketings. Hierbei werden alle potentielle Kunden mit den gleichen riesigen Katalogen, ungezählten Werbebroschüren, aufdringlichen Lautsprecherdurchsagen und schrillen Bannerwerbungen bearbeitet. Im Ergebnis sind nicht nur die Kunden genervt, sondern auch die Rücklaufraten von Marketingkampagnen seit Jahren fallend. Um dies zu vermeiden, ist eine Individualisierung des Massenmarketings empfehlenswert, in der Kunden auf sie zugeschnittene, individuelle Angebote erhalten. Die Aufgabe besteht darin, dem richtigen Kunden zum richtigen Zeitpunkt zum richtigen Preis das richtige Angebot zu unterbreiten. Dies stellt sich primär als eine mathematische Aufgabenstellung heraus, die die Bereiche Statistik, Optimierung, Analysis und Numerik betrifft. Die hierbei auftretenden Aufgabenstellungen der Regressionsanalyse, des Clusterings und der Optimalen Steuerung sind durch hohe Dimensionen und riesige Datenmengen gekennzeichnet und erfordern neue mathematische Konzepte und Verfahren.

  18. Organisation des gesundheitlichen Verbraucherschutzes auf Bundesebene

    NASA Astrophysics Data System (ADS)

    Tschiersky-Schöneburg, Helmut; Büttner, Antje

    Zahlreiche Krisen wie Dioxin belastete Futtermittel, die missbräuchliche Verwendung von Antibiotika in der Schweinemast und nicht zuletzt das Auftreten von BSE in Deutschland erschütterten Ende der neunziger Jahre das Vertrauen der Bürger in die Sicherheit der Lebensmittel. Mit dem Weißbuch zur Lebensmittelsicherheit, das im Januar 2000 herausgegeben wurde, hatte die Europäische Kommission ihre Erfahrungen aus dem BSE-Geschehen in ein neues Konzept für den Verbraucherschutz eingearbeitet. Kernstücke des Konzepts sind die ganzheitliche Betrachtung der Lebensmittelsicherheit von der landwirtschaftlichen Erzeugung bis zum Verzehr und der Anspruch nach Transparenz und Unabhängigkeit der Risikobewertung.

  19. Darwin, Engels und die Rolle der Arbeit in der biologischen und kulturellen Evolution des Menschen

    NASA Astrophysics Data System (ADS)

    Reichholf, Josef H.

    Im Jahre 1876, 5 Jahre nach Erscheinen von Darwins Buch über die Evolution des Menschen und die sexuelle Selektion (Darwin 1871), veröffentlichte Friedrich Engels den berühmt gewordenen Essay "Anteil der Arbeit an der Menschwerdung des Affen“ (Engels 1876). Die Kernfrage darin lautet in Kurzform: Warum hat der Mensch eigentlich ein Bedürfnis nach Arbeit? Engels Antwort wird nachfolgend näher betrachtet und vom gegenwärtigen Kenntnisstand aus beurteilt. Wie sich zeigen wird, beantworten seine Überlegungen die Frage nicht wirklich. Sie ist weiterhin offen. Es können lediglich einige zusätzliche Anhaltspunkte zur Diskussion gestellt werden. Angesichts des drängenden Problems millionenfacher Arbeitslosigkeit und der Forderungen nach einem "Grundrecht auf Arbeit“ kommt den Überlegungen zum möglichen Ursprung des Bedürfnisses nach Arbeit mehr als nur akademisches Interesse zu.

  20. LC-IMS-MS Feature Finder

    Energy Science and Technology Software Center (ESTSC)

    2013-03-07

    LC-IMS-MS Feature Finder is a command line software application which searches for possible molecular ion signatures in multidimensional liquid chromatography, ion mobility spectrometry, and mass spectrometry data by clustering deisotoped peaks with similar monoisotopic mass values, charge states, elution times, and drift times. The software application includes an algorithm for detecting multiple conformations and co-eluting species in the ion mobility dimension. LC-IMS-MS Feature Finder is designed to create an output file with detected features thatmore » includes associated information about the detected features.« less

  1. Magnetospheric research as accomplished by IMS mission

    NASA Astrophysics Data System (ADS)

    Singh, R. N.

    1990-12-01

    This study is based on the International Magnetospheric Study (IMS) program launched and carried out during 1976-1979. Brief descriptions of various experiments aboard the different satellites are given. The magnetospheric features revealed by these measurements are described and discussed. The experiments covered include those aboard the ISEE, GEOS, ATS-6, P78-2 (SCATHA), S3-3, and Prognoz-7 missions. The IMS ground-based experiments are also briefly outlined. Among the results discussed are the tangential and rotational discontinuities in the magnetopause, flux transfer events at the magnetopause, plasma sheet and magnetotail phenomena, and the magnetosphere-ionosphere coupling.

  2. LC-IMS-MS Feature Finder

    SciTech Connect

    2013-03-07

    LC-IMS-MS Feature Finder is a command line software application which searches for possible molecular ion signatures in multidimensional liquid chromatography, ion mobility spectrometry, and mass spectrometry data by clustering deisotoped peaks with similar monoisotopic mass values, charge states, elution times, and drift times. The software application includes an algorithm for detecting multiple conformations and co-eluting species in the ion mobility dimension. LC-IMS-MS Feature Finder is designed to create an output file with detected features that includes associated information about the detected features.

  3. The DES Science Verification weak lensing shear catalogues

    NASA Astrophysics Data System (ADS)

    Jarvis, M.; Sheldon, E.; Zuntz, J.; Kacprzak, T.; Bridle, S. L.; Amara, A.; Armstrong, R.; Becker, M. R.; Bernstein, G. M.; Bonnett, C.; Chang, C.; Das, R.; Dietrich, J. P.; Drlica-Wagner, A.; Eifler, T. F.; Gangkofner, C.; Gruen, D.; Hirsch, M.; Huff, E. M.; Jain, B.; Kent, S.; Kirk, D.; MacCrann, N.; Melchior, P.; Plazas, A. A.; Refregier, A.; Rowe, B.; Rykoff, E. S.; Samuroff, S.; Sánchez, C.; Suchyta, E.; Troxel, M. A.; Vikram, V.; Abbott, T.; Abdalla, F. B.; Allam, S.; Annis, J.; Benoit-Lévy, A.; Bertin, E.; Brooks, D.; Buckley-Geer, E.; Burke, D. L.; Capozzi, D.; Carnero Rosell, A.; Carrasco Kind, M.; Carretero, J.; Castander, F. J.; Clampitt, J.; Crocce, M.; Cunha, C. E.; D'Andrea, C. B.; da Costa, L. N.; DePoy, D. L.; Desai, S.; Diehl, H. T.; Doel, P.; Fausti Neto, A.; Flaugher, B.; Fosalba, P.; Frieman, J.; Gaztanaga, E.; Gerdes, D. W.; Gruendl, R. A.; Gutierrez, G.; Honscheid, K.; James, D. J.; Kuehn, K.; Kuropatkin, N.; Lahav, O.; Li, T. S.; Lima, M.; March, M.; Martini, P.; Miquel, R.; Mohr, J. J.; Neilsen, E.; Nord, B.; Ogando, R.; Reil, K.; Romer, A. K.; Roodman, A.; Sako, M.; Sanchez, E.; Scarpine, V.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Swanson, M. E. C.; Tarle, G.; Thaler, J.; Thomas, D.; Walker, A. R.; Wechsler, R. H.

    2016-08-01

    We present weak lensing shear catalogues for 139 square degrees of data taken during the Science Verification (SV) time for the new Dark Energy Camera (DECam) being used for the Dark Energy Survey (DES). We describe our object selection, point spread function estimation and shear measurement procedures using two independent shear pipelines, IM3SHAPE and NGMIX, which produce catalogues of 2.12 million and 3.44 million galaxies respectively. We detail a set of null tests for the shear measurements and find that they pass the requirements for systematic errors at the level necessary for weak lensing science applications using the SV data. We also discuss some of the planned algorithmic improvements that will be necessary to produce sufficiently accurate shear catalogues for the full 5-year DES, which is expected to cover 5000 square degrees.

  4. The DES Science Verification Weak Lensing Shear Catalogs

    SciTech Connect

    Jarvis, M.

    2015-07-20

    We present weak lensing shear catalogs for 139 square degrees of data taken during the Science Verification (SV) time for the new Dark Energy Camera (DECam) being used for the Dark Energy Survey (DES). We describe our object selection, point spread function estimation and shear measurement procedures using two independent shear pipelines, IM3SHAPE and NGMIX, which produce catalogs of 2.12 million and 3.44 million galaxies respectively. We also detail a set of null tests for the shear measurements and find that they pass the requirements for systematic errors at the level necessary for weak lensing science applications using the SV data. Furthermore, we discuss some of the planned algorithmic improvements that will be necessary to produce sufficiently accurate shear catalogs for the full 5-year DES, which is expected to cover 5000 square degrees.

  5. The DES Science Verification weak lensing shear catalogues

    NASA Astrophysics Data System (ADS)

    Jarvis, M.; Sheldon, E.; Zuntz, J.; Kacprzak, T.; Bridle, S. L.; Amara, A.; Armstrong, R.; Becker, M. R.; Bernstein, G. M.; Bonnett, C.; Chang, C.; Das, R.; Dietrich, J. P.; Drlica-Wagner, A.; Eifler, T. F.; Gangkofner, C.; Gruen, D.; Hirsch, M.; Huff, E. M.; Jain, B.; Kent, S.; Kirk, D.; MacCrann, N.; Melchior, P.; Plazas, A. A.; Refregier, A.; Rowe, B.; Rykoff, E. S.; Samuroff, S.; Sánchez, C.; Suchyta, E.; Troxel, M. A.; Vikram, V.; Abbott, T.; Abdalla, F. B.; Allam, S.; Annis, J.; Benoit-Lévy, A.; Bertin, E.; Brooks, D.; Buckley-Geer, E.; Burke, D. L.; Capozzi, D.; Carnero Rosell, A.; Carrasco Kind, M.; Carretero, J.; Castander, F. J.; Clampitt, J.; Crocce, M.; Cunha, C. E.; D'Andrea, C. B.; da Costa, L. N.; DePoy, D. L.; Desai, S.; Diehl, H. T.; Doel, P.; Fausti Neto, A.; Flaugher, B.; Fosalba, P.; Frieman, J.; Gaztanaga, E.; Gerdes, D. W.; Gruendl, R. A.; Gutierrez, G.; Honscheid, K.; James, D. J.; Kuehn, K.; Kuropatkin, N.; Lahav, O.; Li, T. S.; Lima, M.; March, M.; Martini, P.; Miquel, R.; Mohr, J. J.; Neilsen, E.; Nord, B.; Ogando, R.; Reil, K.; Romer, A. K.; Roodman, A.; Sako, M.; Sanchez, E.; Scarpine, V.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Swanson, M. E. C.; Tarle, G.; Thaler, J.; Thomas, D.; Walker, A. R.; Wechsler, R. H.

    2016-08-01

    We present weak lensing shear catalogues for 139 square degrees of data taken during the Science Verification (SV) time for the new Dark Energy Camera (DECam) being used for the Dark Energy Survey (DES). We describe our object selection, point spread function estimation and shear measurement procedures using two independent shear pipelines, IM3SHAPE and NGMIX, which produce catalogues of 2.12 million and 3.44 million galaxies, respectively. We detail a set of null tests for the shear measurements and find that they pass the requirements for systematic errors at the level necessary for weak lensing science applications using the SV data. We also discuss some of the planned algorithmic improvements that will be necessary to produce sufficiently accurate shear catalogues for the full 5-yr DES, which is expected to cover 5000 square degrees.

  6. The DES Science Verification Weak Lensing Shear Catalogs

    DOE PAGESBeta

    Jarvis, M.

    2016-05-01

    We present weak lensing shear catalogs for 139 square degrees of data taken during the Science Verification (SV) time for the new Dark Energy Camera (DECam) being used for the Dark Energy Survey (DES). We describe our object selection, point spread function estimation and shear measurement procedures using two independent shear pipelines, IM3SHAPE and NGMIX, which produce catalogs of 2.12 million and 3.44 million galaxies respectively. We also detail a set of null tests for the shear measurements and find that they pass the requirements for systematic errors at the level necessary for weak lensing science applications using the SVmore » data. Furthermore, we discuss some of the planned algorithmic improvements that will be necessary to produce sufficiently accurate shear catalogs for the full 5-year DES, which is expected to cover 5000 square degrees.« less

  7. The DES Science Verification Weak Lensing Shear Catalogues

    NASA Astrophysics Data System (ADS)

    Jarvis, M.; Sheldon, E.; Zuntz, J.; Kacprzak, T.; Bridle, S. L.; Amara, A.; Armstrong, R.; Becker, M. R.; Bernstein, G. M.; Bonnett, C.; Chang, C.; Das, R.; Dietrich, J. P.; Drlica-Wagner, A.; Eifler, T. F.; Gangkofner, C.; Gruen, D.; Hirsch, M.; Huff, E. M.; Jain, B.; Kent, S.; Kirk, D.; MacCrann, N.; Melchior, P.; Plazas, A. A.; Refregier, A.; Rowe, B.; Rykoff, E. S.; Samuroff, S.; Sánchez, C.; Suchyta, E.; Troxel, M. A.; Vikram, V.; Abbott, T.; Abdalla, F. B.; Allam, S.; Annis, J.; Benoit-Lévy, A.; Bertin, E.; Brooks, D.; Buckley-Geer, E.; Burke, D. L.; Capozzi, D.; Rosell, A. Carnero; Kind, M. Carrasco; Carretero, J.; Castander, F. J.; Clampitt, J.; Crocce, M.; Cunha, C. E.; D'Andrea, C. B.; da Costa, L. N.; DePoy, D. L.; Desai, S.; Diehl, H. T.; Doel, P.; Neto, A. Fausti; Flaugher, B.; Fosalba, P.; Frieman, J.; Gaztanaga, E.; Gerdes, D. W.; Gruendl, R. A.; Gutierrez, G.; Honscheid, K.; James, D. J.; Kuehn, K.; Kuropatkin, N.; Lahav, O.; Li, T. S.; Lima, M.; March, M.; Martini, P.; Miquel, R.; Mohr, J. J.; Neilsen, E.; Nord, B.; Ogando, R.; Reil, K.; Romer, A. K.; Roodman, A.; Sako, M.; Sanchez, E.; Scarpine, V.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Swanson, M. E. C.; Tarle, G.; Thaler, J.; Thomas, D.; Walker, A. R.; Wechsler, R. H.

    2016-05-01

    We present weak lensing shear catalogues for 139 square degrees of data taken during the Science Verification (SV) time for the new Dark Energy Camera (DECam) being used for the Dark Energy Survey (DES). We describe our object selection, point spread function estimation and shear measurement procedures using two independent shear pipelines, IM3SHAPE and NGMIX, which produce catalogues of 2.12 million and 3.44 million galaxies respectively. We detail a set of null tests for the shear measurements and find that they pass the requirements for systematic errors at the level necessary for weak lensing science applications using the SV data. We also discuss some of the planned algorithmic improvements that will be necessary to produce sufficiently accurate shear catalogues for the full 5-year DES, which is expected to cover 5000 square degrees.

  8. Des ballons pour demain

    NASA Astrophysics Data System (ADS)

    Régipa, R.

    A partir d'une théorie sur la détermination des formes et des contraintes globales d'un ballon de révolution, ou s'en rapprochant, une nouvelle famille de ballons a été définie. Les ballons actuels, dits de ``forme naturelle'', sont calculés en général pour une tension circonférencielle nulle. Ainsi, pour une mission donnée, la tension longitudinale et la forme de l'enveloppe sont strictement imposées. Les ballons de la nouvelle génération sont globalement cylindriques et leurs pôles sont réunis par un câble axial, chargé de transmettre une partie des efforts depuis le crochet (pôle inférieur), directement au pôle supérieur. De plus, la zone latérale cylindrique est soumise à un faible champ de tensions circonférencielles. Ainsi, deux paramètres permettent de faire évoluer la distribution des tensions et la forme de l'enveloppe: - la tension du câble de liaison entre pôles (ou la longueur de ce câble) - la tension circonférencielle moyenne désirée (ou le rayon du ballon). On peut donc calculer et réaliser: - soit des ballons de forme adaptée, comme les ballons à fond plat pour le bon fonctionnement des montgolfières infrarouge (projet MIR); - soit des ballons optimisés pour une bonne répartition des contraintes et une meilleure utilisation des matériaux d'enveloppe, pour l'ensemble des programmes stratosphériques. Il s'ensuit une économie sensible des coûts de fabrication, une fiabilité accrue du fonctionnement de ces ballons et une rendement opérationnel bien supérieur, permettant entre autres, d'envisager des vols à très haute altitude en matériaux très légers.

  9. Amputation des quatre membres

    PubMed Central

    Feruzi, Maruis Kitembo; Milindi, Cédrick Sangwa; Zabibu, Mireille Kakinga; Mulefu, Jules Panda; Katombe, Francois Tshilombo

    2014-01-01

    Les auteurs présentent les cas d'amputation des quatre membres réalisée chez trois patients différents. Ce sont des amputations réalisées pour chaque patient au cours d'une seule hospitalisation et en un seul temps opératoire. Deux patients pour gangrène sèche infectée et un pour amputation traumatique des quatre membres. L'amputation d'urgence a été pratiquée en premier temps suivie de remodelage des moignons d'amputation en second temps. L’évolution de tous les patients a été bonne. PMID:25469177

  10. A Learning Design Ontology Based on the IMS Specification

    ERIC Educational Resources Information Center

    Amorim, Ricardo R.; Lama, Manuel; Sanchez, Eduardo; Riera, Adolfo; Vila, Xose A.

    2006-01-01

    In this paper, we present an ontology to represent the semantics of the IMS Learning Design (IMS LD) specification, a meta-language used to describe the main elements of the learning design process. The motivation of this work relies on the expressiveness limitations found on the current XML-Schema implementation of the IMS LD conceptual model. To…

  11. THOR Ion Mass Spectrometer instrument - IMS

    NASA Astrophysics Data System (ADS)

    Retinò, Alessandro; Kucharek, Harald; Saito, Yoshifumi; Fraenz, Markus; Verdeil, Christophe; Leblanc, Frederic; Techer, Jean-Denis; Jeandet, Alexis; Macri, John; Gaidos, John; Granoff, Mark; Yokota, Shoichiro; Fontaine, Dominique; Berthomier, Matthieu; Delcourt, Dominique; Kistler, Lynn; Galvin, Antoniette; Kasahara, Satoshi; Kronberg, Elena

    2016-04-01

    Turbulence Heating ObserveR (THOR) is the first mission ever flown in space dedicated to plasma turbulence. Specifically, THOR will study how turbulent fluctuations at kinetic scales heat and accelerate particles in different turbulent environments within the near-Earth space. To achieve this goal, THOR payload is being designed to measure electromagnetic fields and particle distribution functions with unprecedented resolution and accuracy. Here we present the Ion Mass Spectrometer (IMS) instrument that will measure the full three-dimensional distribution functions of near-Earth main ion species (H+, He+, He++ and O+) at high time resolution (~ 150 ms for H+ , ~ 300 ms for He++) with energy resolution down to ~ 10% in the range 10 eV/q to 30 keV/q and angular resolution ~ 10°. Such high time resolution is achieved by mounting multiple sensors around the spacecraft body, in similar fashion to the MMS/FPI instrument. Each sensor combines a top-hat electrostatic analyzer with deflectors at the entrance together with a time-of-flight section to perform mass selection. IMS electronics includes a fast sweeping high voltage board that is required to make measurements at high cadence. Ion detection includes Micro Channel Plates (MCP) combined with Application-Specific Integrated Circuits (ASICs) for charge amplification, discrimination and time-to-digital conversion (TDC). IMS is being designed to address many of THOR science requirements, in particular ion heating and acceleration by turbulent fluctuations in foreshock, shock and magnetosheath regions. The IMS instrument is being designed and will be built by an international consortium of scientific institutes with main hardware contributions from France, USA, Japan and Germany.

  12. Toward an Intelligent Ion Mobility Spectrometer (IMS)

    SciTech Connect

    Timothy R. McJunkin; Jill R. Scott; Carla J. Miller

    2003-07-01

    The ultimate goal is to design and build a very smart ion mobility spectrometer (IMS) that can operate autonomously. To accomplish this, software capable of interpreting spectra so that it can be used in control loops for data interpretation as well as adjusting instrument parameters is being developed. Fuzzy logic and fuzzy numbers are used in this IMS spectra classification scheme. Fuzzy logic provides a straight forward method for developing a classification/detection system, whenever rules for classifying the spectra can be described linguistically. Instead of using 'max' and 'min' values, the product of the truth values is used to determine class membership. Using the product allows rule-bases that utilize the AND function to allow each condition to discount truth value in determining membership, while rule-bases with an OR function are allowed to accumulate membership. Fuzzy numbers allow encapsulation of the uncertainties due to ion mobility peak widths as well as measured instrumental parameters, such as pressure and temperature. Associating a peak with a value of uncertainty, in addition to making adjustments to the mobility calculation based on variations in measured parameters, enables unexpected shifts to be more reliably detected and accounted for; thereby, reducing the opportunity for 'false negative' results. The measure of uncertainty is anticipated to serve the additional purpose of diagnosing the operational conditions of the IMS instrument.

  13. Development of a high-throughput IMS-IMS-MS approach for analyzing mixtures of biomolecules

    PubMed Central

    Kurulugama, Ruwan T.; Valentine, Stephen J.; Sowell, Rena A.; Clemmer, David E.

    2008-01-01

    A high-throughput approach for biomolecule analysis is demonstrated for a mixture of peptides from tryptic digest of four proteins as well as a tryptic digests of human plasma. In this method a chip-based electrospray autosampler coupled to a hybrid ion mobility (IMS) mass spectrometer (MS) is utilized to achieve rapid sample analysis. This high-throughput measurement is realized by exploiting the direct infusion capability of the chip based electrospray with its rapid sample manipulating capability as well as a high sensitive IMS-MS with a recently developed IMS-IMS separation technique that can be multiplexed to provide greater throughput. From replicate IMS-MS runs of known mixtures, the average uncertainty of peak intensities is determined to be ±7% (relative standard deviation), and a detection limit in the low attomole range is established. The method is illustrated by analyzing 124 human plasma protein samples in duplicate, a measurement that required 16.5 hours. Current limitations as well as implications of the high-throughput approach for complex biological sample analysis are discussed. PMID:18590839

  14. Tiefenwässer im Oberen Muschelkalk-Aquifer des Oberrheingrabens und des Südwestdeutschen Molassebeckens

    NASA Astrophysics Data System (ADS)

    Stober, Ingrid; Jodocy, Marco; Burisch, Mathias; Person, Ralf

    2013-06-01

    Hydrochemical data from deep wells in the Upper Rhine Graben area in France and Germany (Baden-Wuerttemberg) and in the Molasse Basin were collected and examined. Target formations were the Upper and the Lower Muschelkalk aquifer. The hydrochemical data were used to characterize the fluids found in the deep hydrothermal reservoirs and provide information about the origin and development of the deep waters. Saturation states of the deep seated waters are discussed with respect to selected minerals and the influence of temperature and pressure variations on pH and saturation states were determined.

  15. Unentbehrlich in Natur, Technik und Forschung: Flüssigkristalle im Überblick

    NASA Astrophysics Data System (ADS)

    Mathelitsch, Leopold; Repnik, Robert; Bradac, Zlatko; Vilfan, Mojca; Kralj, Samo

    2003-05-01

    Flüssigkristalle können wie eine Flüssigkeit fließen und zugleich eine innere Ordnung besitzen, die an Festkörper erinnert. Sie begegnen uns im Alltag in vielen technischen Anwendungen, beispielsweise in Displays von elektronischen Geräten. Seit Millionen von Jahren sind sie schon zentrale Bausteine von biologischen Systemen. Dazu zählen zum Beispiel die DNS, viele Proteine und die Membran, die lebende Zellen umschließt. Wegen ihrer besonderen Eigenschaften eignen sich Flüssigkristalle gut als Analogien für andere physikalische Systeme: zum Beispiel die Teilchen-Antiteilchen-Annihilation oder kosmologische Modelle des Universums kurz nach dem Urknall.

  16. Regenerative Energieträger im Aufwind: Entwicklung der erneuerbaren Energien

    NASA Astrophysics Data System (ADS)

    Kohl, Harald

    2006-05-01

    2005 kam 4,6 % des deutschen Primär-Energieverbrauchs aus erneuerbaren Energiequellen, bei der Stromproduktion lag ihr Anteil bei 10,2 %. Wesentliche Ursache ist der Boom bei der Windkraft, die vor allem durch Offshore-Windparks auf See weiter ausbaubar ist. Die Wasserkraft lieferte in Deutschland traditionell einen großen Beitrag zur Stromerzeugung, doch ihr Ausbaupotenzial ist gering. Die Photovoltaik, die solar- und die geothermische Stromerzeugung spielen derzeit noch eine kleine Rolle. Den deutschen Bedarf an Wärmeenergie deckten 2004 die erneuerbaren Energien zu 5,4 %, vor allem aus Biomasse. Die solarthermische Wärmeerzeugung hat sich gegenüber 2000 mehr als verdoppelt. Im Straßenverkehr spielen biogene Kraftstoffe mit 5,4 % noch eine untergeordnete Rolle. Bis 2050 könnte in Deutschland der Anteil regenerativer Energien am Primär-Energieverbrauch die Fünfzigprozentmarke überschreiten.

  17. Des Vents et des Jets Astrophysiques

    NASA Astrophysics Data System (ADS)

    Sauty, C.

    well expected result from the theory. Although, collimation may be conical, paraboloidal or cylindrical (Part 4), cylindrical collimation is the more likely to occur. The shape of outflows may then be used as a tool to predict physical conditions on the flows or on their source. L'éjection continue de plasma autour d'objets massifs est un phénomène largement répandu en astrophysique, que ce soit sous la forme du vent solaire, de vents stellaires, de jets d'étoiles en formation, de jets stellaires autour d'objets compacts ou de jets extra-galactiques. Cette zoologie diversifiée fait pourtant l'objet d'un commun effort de modélisation. Le but de cette revue est d'abord de présenter qualitativement le développement, depuis leur origine, des diverses théories de vents (Partie 1) et l'inter disciplinarité dans ce domaine. Il s'agit d'une énumération, plus ou moins exhaustive, des idées proposées pour expliquer l'accélération et la morphologie des vents et des jets, accompagnée d'une présentation sommaire des aspects observationnels. Cette partie s'abstient de tout aspect faisant appel au formalisme mathématique. Ces écoulements peuvent être décrits, au moins partiellement, en résolvant les équations magnétohydrodynamiques, axisymétriques et stationnaires. Ce formalisme, à la base de la plupart des théories, est exposé dans la Partie 2. Il permet d'introduire quantitativement les intégrales premières qu'un tel système possède. Ces dernières sont amenées à jouer un rôle important dans la compréhension des phénomènes d'accélération ou de collimation, en particulier le taux de perte de masse, le taux de perte de moment angulaire ou l'énergie du rotateur magnétique. La difficulté de modélisation réside dans l'existence de points critiques, propres aux équations non linéaires, qu'il faut franchir. La nature physique et la localisation de ces points critiques fait l'objet d'un débat important car ils sont la clef de voute de la r

  18. Evaluation of Arizona's enhanced I/M program

    SciTech Connect

    Wenzel, Tom

    1999-04-21

    MOBILE5 slightly overpredicts initial reductions in CO and HC, and dramatically overpredicts initial reductions in NOx. About one-third of the vehicles that fail initial I/M testing do not complete the I/M program. Only a small portion of these receive a waiver. Initial I/M repair effectiveness as measured by remote sensing is only half of that as measured by IM240. Possible causes are sensitivity to operating mode, and how long after repair emissions are measured. 37% of the vehicles that initially fail and eventually pass in 1995 fail again in 1997. Half of these fail for the same combination of pollutants in both years. Vehicles that never pass the Im240 are still being driven in the I/M area; these vehicles are from all model years.

  19. ";... Physica autem sine omni experimento instituta sicca sit et sterilis`` Warum im Jahr 1771 trotz guter Argumente der Plan, in Melk eine Sternwarte zu errichten, nicht zur Ausführung kam.

    NASA Astrophysics Data System (ADS)

    Glaßner, Gottfried; Preiner, Christine

    2009-06-01

    Am 20. August 1771 weilte der namhafte Wiener Universitätsprofessor, Astronom der Kaiserin und Mitarbeiter der Wiener Universitätssternwarte P. Joseph Liesganig SJ zu Gast im Stift Melk. Gegenüber Abt Urban Hauer (1763-1785) äußerte er die Idee, auf dem Pulverturm im Norden der Klosteranlage eine Sternwarte zu errichten. Den Aufzeichnungen in den Tagebüchern des Priorats ist zu entnehmen, dass der Abt an dem Vorschlag sofort Gefallen fand, weil er meinte, dass eine Physik mit Experimenten und eine Astronomie mit Beobachtungsmöglichkeiten die Freude am Lernen fördere. Aber am 2. Dezember 1771, als das Projekt auf der Tagesordnung des Kapitels stand, endete die Diskussion zwischen Gegnern und Befürwortern des Sternwarte-Projekts in einem Eklat, noch ehe es zu einer Abstimmung kommen konnte. Der Abt, der als wichtigste Voraussetzung für ein Gelingen des Projektes die Freude der Beteiligten gesehen hatte, ließ darauf verkünden, dass das Thema "um des lieben Friedens willen“ nicht mehr zur Diskussion stehe.

  20. A new IMS Seismic Array in Niger

    NASA Astrophysics Data System (ADS)

    Estabrook, C. H.; Barrientos, S.; Bergsson, B. H.; Boureima, O. A.; Ebeling, C.; Hfaiedh, M.; Soumana, S.; Suarez, G.

    2006-12-01

    The International Monitoring System (IMS) of the Preparatory Commission of the Comprehensive Nuclear Test- Ban Treaty Organization (CTBTO) has built a sixteen element broadband seismic array in southwestern Niger near the town of Torodi. This is the first array to be built in West Africa. The array has a diameter of 6 km (three rings with a central element), contains twelve vertical and four 3-component broadband sensors, all with identical instrument responses (Guralp CMG-3TB broadband sensors, flat to velocity from 100 seconds to 20 Hz). All sensors are deployed at 50 meters depth in boreholes. Many elements have seismic noise characteristics at or below Peterson's Low Noise Model at frequencies higher than 0.5 Hz. The array is autonomous: it is powered entirely by solar power, and transmits data directly to Vienna via VSAT with about a 20 second delay from real time. Data availability is nearly 100% since January 2006. The array is entirely on 2 billion year old granodiorite/tonalite with all of the sensors emplaced within the crystalline rock. A receiver function performs on the data shows a very simple crustal structure with a Moho depth of 38 km. The array is capable of resolving and detecting events with magnitude (mb) less than 3.0 from events in Peru and Indonesia, showing that the array significantly adds to the IMS detection capabilities in the Africa region and world-wide.

  1. Zur Entwicklung des qualitativen Adverbs im Deutschen (On the Development of the Qualitative Adverb in German)

    ERIC Educational Resources Information Center

    Paraschkewoff, Boris

    1974-01-01

    The contemporary German, predicate adjective and adjectival adverb are expressed by the same form. Although modern grammatical research gathers the various functions of the adjective under "indicator of kind," school practice still separates adjective and adverb. The historical development of qualitative adverbs is outlined. (Text is in German.)…

  2. Erfahrungen im Aufbau des IT Service Desks der Technischen Universität München

    NASA Astrophysics Data System (ADS)

    Vellguth, Karmela

    Durch das Projekt IntegraTUM und die darin eingebettete Einrichtung eines IT Service Desks mit 1st, 2nd und 3rd Level Support gelang eine an ITIL orientierte Neuausrichtung der internen IT-Dienstleistungen. Die vormals existierende Struktur mit einer Vielzahl an Ansprechpartnern bei auftretenden IT-Problemen wurde aufgelöst. Die Nutzer haben nun eine Anlaufstelle erhalten, die sich für die Beantwortung aller Incidents in kürzester Zeit und mit qualitativ hohem Niveau zuständig fühlt.

  3. Functional Overview of SWRL/IMS Version 3.

    ERIC Educational Resources Information Center

    McManus, John F.

    Version 3 of the Southwest Regional Laboratory's (SWRL) Instructional Management System (IMS) is a fully automated system which accepts pupil criterion exercises from remote sites and returns various reports to the same location. This paper briefly describes the SWRL/IMS system design and functional characteristics. The instructional system…

  4. OPSN: The IMS COMSYS 1 and 2 Data Preprocessing System.

    ERIC Educational Resources Information Center

    Yu, John

    The Instructional Management System (IMS) developed by the Southwest Regional Laboratory (SWRL) processes student and teacher-generated data through the use of an optical scanner that produces a magnetic tape (Scan Tape) for input to IMS. A series of computer routines, OPSN, preprocesses the Scan Tape and prepares the data for transmission to the…

  5. I'm Pregnant. Should I Get a Flu Shot?

    MedlinePlus

    ... Cuts? I'm Pregnant. Should I Get a Flu Shot? KidsHealth > For Teens > I'm Pregnant. Should I Get a Flu Shot? Print A A A Text Size I ... weeks pregnant. Do I need to get the flu vaccine or will it affect my pregnancy? – Eliza* ...

  6. GC-IMS: a technology for many applications

    NASA Astrophysics Data System (ADS)

    Haley, Lawrence V.; Romeskie, Julian M.

    1998-12-01

    Fast GC (gas chromatography) - IMS (ion mobility spectrometry) as a core technology is sufficiently flexible with respect to a broad range of chemical detection capabilities. The application of this dual technology can provide unique solutions in many operational environments. GC-IMS is the next evolutionary step in the advancement of IMS technology. Using the advantages of IMS (i.e., small, high sensitivity, rugged, operates at atmospheric pressure, etc.) And the chemical selection capability of GC, this detector configuration can be customized to detect and identify explosives, ICAO markers, and narcotics. This paper will present a technical discussion on GC-IMS and describe several commercial off the shelf (COTS) systems with potential application in many operating environments. Instruments include the Orion for explosives detection, Ariel for narcotics detection, Sirius for both explosives and narcotics detection, and NorthStar for handheld narcotics detection.

  7. IMS R and D program at Canada customs

    NASA Technical Reports Server (NTRS)

    Pilon, Pierre; Mungham, Tony; Ng, Lay-Keow; Lawrence, Andre

    1995-01-01

    Over the last few years, Revenue Canada, in collaboration with Barringer Instruments Limited, has been involved in the development of a field-usable ion mobility spectrometer (IMS) for the detection of drugs of abuse. This work has culminated in the manufacturing and commercialization by Barringer of the Ionscan 350 instruments, now in use by various law enforcement agencies worldwide. Although IMS exhibits a very strong and distinctive response toward some nitrogen containing drugs, e.g., cocaine, like all separation techniques it has inherent limitations, namely moderate resolution and low chemical signal to noise ratio which may affect the reliability of IMS-based drug detectors. A program is in place at the Laboratory and Scientific Services Directorate (LSSD) to investigate the applicability of various digital signal processing (DSP) techniques to IMS output signals. The application of neural network techniques to overlapping IMS peaks is presented.

  8. Reticulation des fibres lignocellulosiques

    NASA Astrophysics Data System (ADS)

    Landrevy, Christel

    Pour faire face à la crise économique la conception de papier à valeur ajoutée est développée par les industries papetières. Le but de se projet est l'amélioration des techniques actuelles de réticulation des fibres lignocellulosiques de la pâte à papier visant à produire un papier plus résistant. En effet, lors des réactions de réticulation traditionnelles, de nombreuses liaisons intra-fibres se forment ce qui affecte négativement l'amélioration anticipée des propriétés physiques du papier ou du matériau produit. Pour éviter la formation de ces liaisons intra-fibres, un greffage sur les fibres de groupements ne pouvant pas réagir entre eux est nécessaire. La réticulation des fibres par une réaction de « click chemistry » appelée cycloaddition de Huisgen entre un azide et un alcyne vrai, catalysée par du cuivre (CuAAC) a été l'une des solutions trouvée pour remédier à ce problème. De plus, une adaptation de cette réaction en milieux aqueux pourrait favoriser son utilisation en milieu industriel. L'étude que nous désirons entreprendre lors de ce projet vise à optimiser la réaction de CuAAC et les réactions intermédiaires (propargylation, tosylation et azidation) sur la pâte kraft, en milieu aqueux. Pour cela, les réactions ont été adaptées en milieu aqueux sur la cellulose microcristalline afin de vérifier sa faisabilité, puis transférée à la pâte kraft et l'influence de différents paramètres comme le temps de réaction ou la quantité de réactifs utilisée a été étudiée. Dans un second temps, une étude des différentes propriétés conférées au papier par les réactions a été réalisée à partir d'une série de tests papetiers optiques et physiques. Mots Clés Click chemistry, Huisgen, CuAAC, propargylation, tosylation, azidation, cellulose, pâte kraft, milieu aqueux, papier.

  9. Isothermal aging of IM7/8320 and IM7/5260

    NASA Technical Reports Server (NTRS)

    Martin, Roderick H.; Siochi, Emilie J.; Gates, Thomas S.

    1992-01-01

    Isothermal aging was conducted on two composite systems being considered as possible candidates for the next generation supersonic transport. The composite systems were IM7/5260, a carbon/thermoset, and IM7/8320, a carbon/amorphous thermoplastic. The materials were isothermally aged for a total of 5000 hours at 125 C and 175 C. These temperatures are approximately equivalent to the upper skin temperatures of an aircraft flying at Mach 2.0 and Mach 2.4, respectively. The variations of the following properties were determined as a function of aging time: weight loss, moduli, glass transition temperature, microcracking, and modulus and strength of a +/- 45 laminate. The difficulties and accuracy of strain measurements are also discussed.

  10. Elektrische Phänomene des Körpers und ihre Detektion

    NASA Astrophysics Data System (ADS)

    Bolz, Armin; Kikillus, Nicole; Moor, Claudius

    Im menschlichen Körper verfügen sowohl Nerven- als auch Muskelzellen über die Eigenschaft, intra- und extrazelluläre Ionenkonzentrationen zu verschieben und damit die Potenzialverteilung in ihrer Umgebung zu beeinflussen. Über unterschiedliche Synchronisationsverfahren sind makroskopische Zellverbände zusätzlich in der Lage, koordiniert ihre Felder zu verändern und somit auch signifikante, an der Körperoberfläche messbare elektrische Signale zu erzeugen. Das vorliegende Kapitel beschreibt zunächst die elektrophysiologischen Grundlagen elektrischer Signale des menschlichen Körpers, die Synchronisationsmechanismen und die daraus entstehenden Felder, insbesondere das Elektrokardiogramm (EKG), das Elektroenzephalogramm (EEG) sowie das Elektromyogramm (EMG). Im Anschluss daran werden die wesentlichen Grundlagen der Messtechnik zur Erfassung bioelektrischer Phänomene erläutert. Einige Beispielapplikationen runden diesen Beitrag ab.

  11. Die neogene Hebungsgeschichte der Patagonischen Anden im Kontext der Subduktion eines aktiven Spreizungszentrums

    NASA Astrophysics Data System (ADS)

    Warkus, Frank

    2002-05-01

    Das Phänomen der Subduktion eines aktiven Spreizungszentrums an der Südspitze Südamerikas ist seit langem bekannt. Eine Vielzahl von geologischen Beobachtungen wurden mit diesem Phänomen in Verbindung gebracht, trotzdem ist der genaue Mechanismus der Beeinflussung des aktiven Kontinentalrandes weitgehend unbekannt. Die Zusammenhänge zwischen den Subduktionsprozessen und der Entwicklung der patagonischen Anden zwischen 47°S und 48°S stehen im Mittelpunkt der Untersuchungen. Um eine detaillierte zeitliche Auflösung der zugrunde liegenden Prozesse untersuchen zu können, wurde die Entwicklung der Vorlandsedimentation, die thermische Entwicklung und die Heraushebung der Oberkruste des andinen Orogens untersucht und diese in Bezug zur Subduktion des Chile-Rückens gesetzt. Im Bereich von 47°30′S wurden die synorogenen Vorlandsedimente der Santa Cruz Formation sedimentologisch untersucht. Diese fluviatilen Sedimente wurden in einem reliefarmen Vorlandgebiet durch häufige Rinnenverlagerung und dem Aufbau von Rinnenumlagerungsgürteln in Kombination mit assoziierten groräumigen Überflutungsablagerungen akkumuliert. Sie stehen in einem engen Zusammenhang mit der orogenen Entwicklung im andinen Liefergebiet. Dies spiegelt sich in dem nach oben gröber werdenden Zyklus der Santa Cruz Formation wider. Die magnetostratigraphischen Untersuchungen einer 270 m mächtigen Sequenz aus der Basis der Santa Cruz Formation, die mit 329 Einzelproben aus 96 Probenpunkten beprobt wurde, ergab 7 Umkehrungen der geomagnetischen Feldrichtung. Mit Hilfe der geomagnetischen Polaritätszeitskala (CANDE AND KENT, 1995) konnte der untersuchte Abschnitt der Santa Cruz Formation zwischen 16.2 und 18.5 Ma datiert werden. Als Träger der Sedimentations-Remanenz konnten überwiegend Pseudoeinbereichs-Magentitpartikel und untergeordnet Hämatitpartikel identifiziert werden. An drei Profilen der Santa Cruz Formation wurden aus Sandsteinlagen unterschiedlicher stratigraphischer Position

  12. No Sex Please, I'm a Stressed New Mom

    MedlinePlus

    ... https://medlineplus.gov/news/fullstory_159263.html No Sex Please, I'm a Stressed New Mom Study ... HealthDay News) -- First-time parents may see their sex life hit the skids if mom feels stressed ...

  13. Depth-resolved image mapping spectrometer (IMS) with structured illumination

    NASA Astrophysics Data System (ADS)

    Gao, Liang; Bedard, Noah; Hagen, Nathan; Kester, Robert T.; Tkaczyk, Tomasz S.

    2011-08-01

    We present a depth-resolved Image Mapping Spectrometer (IMS) which is capable of acquiring 4D (x, y, z, λ) datacubes. Optical sectioning is implemented by structured illumination. The device's spectral imaging performance is demonstrated in a multispectral microsphere and mouse kidney tissue fluorescence imaging experiment. We also compare quantitatively the depth-resolved IMS with a hyperspectral confocal microscope (HCM) in a standard fluorescent bead imaging experiment. The comparison results show that despite the use of a light source with four orders of magnitude lower intensity in the IMS than that in the HCM, the image signal-to-noise ratio acquired by the IMS is 2.6 times higher than that achieved by the equivalent confocal approach.

  14. A digital boxcar integrator for IMS spectra

    NASA Technical Reports Server (NTRS)

    Cohen, Martin J.; Stimac, Robert M.; Wernlund, Roger F.; Parker, Donald C.

    1995-01-01

    When trying to detect or quantify a signal at or near the limit of detectability, it is invariably embeded in the noise. This statement is true for nearly all detectors of any physical phenomena and the limit of detectability, hopefully, occurs at very low signal-to-noise levels. This is particularly true of IMS (Ion Mobility Spectrometers) spectra due to the low vapor pressure of several chemical compounds of great interest and the small currents associated with the ionic detection process. Gated Integrators and Boxcar Integrators or Averagers are designed to recover fast, repetitive analog signals. In a typical application, a time 'Gate' or 'Window' is generated, characterized by a set delay from a trigger or gate pulse and a certain width. A Gated Integrator amplifies and integrates the signal that is present during the time the gate is open, ignoring noise and interference that may be present at other times. Boxcar Integration refers to the practice of averaging the output of the Gated Integrator over many sweeps of the detector. Since any signal present during the gate will add linearly, while noise will add in a 'random walk' fashion as the square root of the number of sweeps, averaging N sweeps will improve the 'Signal-to-Noise Ratio' by a factor of the square root of N.

  15. Médecine des voyages

    PubMed Central

    Aw, Brian; Boraston, Suni; Botten, David; Cherniwchan, Darin; Fazal, Hyder; Kelton, Timothy; Libman, Michael; Saldanha, Colin; Scappatura, Philip; Stowe, Brian

    2014-01-01

    Résumé Objectif Définir la pratique de la médecine des voyages, présenter les éléments fondamentaux d’une consultation complète préalable aux voyages à des voyageurs internationaux et aider à identifier les patients qu’il vaudrait mieux envoyer en consultation auprès de professionnels de la médecine des voyages. Sources des données Les lignes directrices et les recommandations sur la médecine des voyages et les maladies liées aux voyages publiées par les autorités sanitaires nationales et internationales ont fait l’objet d’un examen. Une recension des ouvrages connexes dans MEDLINE et EMBASE a aussi été effectuée. Message principal La médecine des voyages est une spécialité très dynamique qui se concentre sur les soins préventifs avant un voyage. Une évaluation exhaustive du risque pour chaque voyageur est essentielle pour mesurer avec exactitude les risques particuliers au voyageur, à son itinéraire et à sa destination et pour offrir des conseils sur les interventions les plus appropriées en gestion du risque afin de promouvoir la santé et prévenir les problèmes médicaux indésirables durant le voyage. Des vaccins peuvent aussi être nécessaires et doivent être personnalisés en fonction des antécédents d’immunisation du voyageur, de son itinéraire et du temps qu’il reste avant son départ. Conclusion La santé et la sécurité d’un voyageur dépendent du degré d’expertise du médecin qui offre le counseling préalable à son voyage et les vaccins, au besoin. On recommande à ceux qui donnent des conseils aux voyageurs d’être conscients de l’ampleur de cette responsabilité et de demander si possible une consultation auprès de professionnels de la médecine des voyages pour tous les voyageurs à risque élevé.

  16. Mercaptursäure und Nukleosidaddukt im Harn als Biomarker in 1-Hydroxymethylpyren-exponierten Ratten

    NASA Astrophysics Data System (ADS)

    Ma, Lan

    2002-01-01

    1-Methylpyren (MP) ist hepatokanzerogen in neugeborenen männlichen Mäusen. Durch Hydroxylierung an der benzylischen Stelle und anschließende Sulfonierung wird MP zu DNA-reaktivem 1-Sulfooxymethylpyren (SMP) aktiviert. In der Ratte führt die Exposition des benzylischen Alkohols, 1-Hydroxymethylpyren (HMP), zur DNA-Adduktbildung in verschiedenen Geweben. Eventuelle Konsequenz der Toxifizierung ist die Ausscheidung entsprechender Mercaptursäure und Nukleosidaddukt im Harn, welche aufgrund ihrer Herkunft als Biomarker eignen könnten. In dieser Arbeit wird die Ausscheidung der Mercaptursäure und des N2-Desoxyguanosinadduktes in HMP-exponierten Ratten untersucht. Nach der Applikation von HMP bzw. MP wurden weniger als 1 % der Dosis als MPMA über Urin und Faeces ausgeschieden (0 - 48 h). Die Ausscheidung erfolgt hauptsächlich in den ersten 24 h nach der Applikation. MPdG konnte weder in Urin noch in Faeces der HMP-behandelten Tieren identifiziert werden. Nach direkter SMP-Applikation wurde MPdG nur in sehr geringe Menge (weniger als 0,9 ppm in 12 h) im Urin gefunden. Aufgrund der geringen Menge eignet sich MPdG nicht als Biomarker. MPMA dagegen, lässt sich analytisch gut erfassen. Es sollte daher untersucht werden, ob MPMA die Toxifizierung des HMP wiederspiegelt. Die Voraussetzung dafür ist die Kenntnisse über das Metabolismusmuster von HMP. Es wurde daher umfassende Untersuchungen zum Metabolismus des HMP durchgeführt. Die Ergebnisse zeigten, dass mehr als 80 % der Metaboiten in ihrer oxidierten Form (PCS, deren Glucuronsäure-Konjugate sowie phenolische Sulfatester der PCS) ausgeschieden wurden. Demnach spielt die Oxidation des HMP zu PCS eine sehr wichtige Rolle bei der Detoxifizierung und Ausscheidung von HMP. Ferne konnte nachgewiesen werden, dass die Enzyme Alkohol- und Aldehyd-Dehydrogenase an der Oxidation von HMP beteiligt waren. Die Inhibitoren Disulfiram und Ethanol der o. g. Enzyme wurde daher zur Modulation der Detoxifizierung in vivo eingesetzt

  17. Towards a Dynamic DES model

    NASA Astrophysics Data System (ADS)

    Subbareddy, Pramod; Candler, Graham

    2009-11-01

    Hybrid RANS/LES methods are being increasingly used for turbulent flow simulations in complex geometries. Spalart's detached eddy simulation (DES) model is one of the more popular ones. We are interested in examining the behavior of the Spalart-Allmaras (S-A) Detached Eddy Simulation (DES) model in its ``LES mode.'' The role of the near-wall functions present in the equations is analyzed and an explicit analogy between the S-A and a one-equation LES model based on the sub-grid kinetic energy is presented. A dynamic version of the S-A DES model is proposed based on this connection. Validation studies and results from DES and LES applications will be presented and the effect of the proposed modification will be discussed.

  18. Vecteurs Singuliers des Theories des Champs Conformes Minimales

    NASA Astrophysics Data System (ADS)

    Benoit, Louis

    En 1984 Belavin, Polyakov et Zamolodchikov revolutionnent la theorie des champs en explicitant une nouvelle gamme de theories, les theories quantiques des champs bidimensionnelles invariantes sous les transformations conformes. L'algebre des transformations conformes de l'espace-temps presente une caracteristique remarquable: en deux dimensions elle possede un nombre infini de generateurs. Cette propriete impose de telles conditions aux fonctions de correlations qu'il est possible de les evaluer sans aucune approximation. Les champs des theories conformes appartiennent a des representations de plus haut poids de l'algebre de Virasoro, une extension centrale de l'algebre conforme du plan. Ces representations sont etiquetees par h, le poids conforme de leur vecteur de plus haut poids, et par la charge centrale c, le facteur de l'extension centrale, commune a toutes les representations d'une meme theorie. Les theories conformes minimales sont constituees d'un nombre fini de representations. Parmi celles-ci se trouvent des theories unitaires dont les representation forment la serie discrete de l'algebre de Virasoro; leur poids h a la forme h_{p,q}(m)=[ (p(m+1) -qm)^2-1] (4m(m+1)), ou p,q et m sont des entiers positifs et p+q<= m+1. L'entier m parametrise la charge centrale: c(m)=1 -{6over m(m+1)} avec n>= 2. Ces representations possedent un sous-espace invariant engendre par deux sous-representations avec h_1=h_{p,q} + pq et h_2=h_{p,q} + (m-p)(m+1-q) dont chacun des vecteurs de plus haut poids portent le nom de vecteur singulier et sont notes respectivement |Psi _{p,q}> et |Psi_{m-p,m+1-q}>. . Les theories super-conformes sont une version super-symetrique des theories conformes. Leurs champs appartiennent a des representation de plus haut poids de l'algebre de Neveu-Schwarz, une des deux extensions super -symetriques de l'algebre de Virasoro. Les theories super -conformes minimales possedent la meme structure que les theories conformes minimales. Les representations

  19. IM Normae: A Second T Pyx? (Abstract)

    NASA Astrophysics Data System (ADS)

    Patterson, J.; Monard, B.; Warhurst, P.; Myers, G.

    2015-12-01

    (Abstract only) T Pyx is the Galaxy's most famous recurrent nova, erupting to magnitude 6 about every 20 years. For nova hunters and variable-star observers generally, it should be quite easy to discover stars with similar properties. There are probably half a million CVs out to the distance of T Pyx, and most have an underlying structure similar to that of T Pyx: low-mass secondary, fairly massive white dwarf, short orbital period. But of these half million stars, there is no second T Pyx. The star is unique in another way: its orbital period is increasing on a timescale of 300,000 years. Like the proverbial bat out of hell. A 2002 nova eruption nominated a second star for this elite club: IM Nor, a short-orbital-period (2.5 hours) star which previously erupted in 1920. We began a program of time-series photometry to track the shallow eclipses—to test for orbital period change, the other signature of T Pyx resemblance. By 2015 we found this effect: Porb increases on a timescale of 2 million years. Thus, the two stars appear to be blowing themselves apart on a timescale of roughly a million years. This could explain why the stars are so rare: because they are rapidly self-immolating. And that could happen because the classical-nova outburst overwhelms the low-mass secondaries that live in short-period CVs—leading to unstable mass transfer which quickly evaporates the secondary. This implies that all short-Porb classical novae should be "recurrent" (erupting on a timescale of decades). Greater attention to CP Pup (1942), RW UMi (1956), GQ Mus (1983), and V Per (1887) is definitely warranted.

  20. Ion mobility spectrometer / mass spectrometer (IMS-MS).

    SciTech Connect

    Hunka Deborah Elaine; Austin, Daniel E.

    2005-07-01

    The use of Ion Mobility Spectrometry (IMS) in the Detection of Contraband Sandia researchers use ion mobility spectrometers for trace chemical detection and analysis in a variety of projects and applications. Products developed in recent years based on IMS-technology include explosives detection personnel portals, the Material Area Access (MAA) checkpoint of the future, an explosives detection vehicle portal, hand-held detection systems such as the Hound and Hound II (all 6400), micro-IMS sensors (1700), ordnance detection (2500), and Fourier Transform IMS technology (8700). The emphasis to date has been on explosives detection, but the detection of chemical agents has also been pursued (8100 and 6400). Combining Ion Mobility Spectrometry (IMS) with Mass Spectrometry (MS) is described. The IMS-MS combination overcomes several limitations present in simple IMS systems. Ion mobility alone is insufficient to identify an unknown chemical agent. Collision cross section, upon which mobility is based, is not sufficiently unique or predictable a priori to be able to make a confident peak assignment unless the compounds present are already identified. Molecular mass, on the other hand, is much more readily interpreted and related to compounds. For a given compound, the molecular mass can be determined using a pocket calculator (or in one's head) while a reasonable value of the cross-section might require hours of computation time. Thus a mass spectrum provides chemical specificity and identity not accessible in the mobility spectrum alone. In addition, several advanced mass spectrometric methods, such as tandem MS, have been extensively developed for the purpose of molecular identification. With an appropriate mass spectrometer connected to an ion mobility spectrometer, these advanced identification methods become available, providing greater characterization capability.

  1. Ion Mobility Spectrometer / Mass Spectrometer (IMS-MS).

    SciTech Connect

    Hunka, Deborah E; Austin, Daniel

    2005-10-01

    The use of Ion Mobility Spectrometry (IMS)in the Detection of Contraband Sandia researchers use ion mobility spectrometers for trace chemical detection and analysis in a variety of projects and applications. Products developed in recent years based on IMS-technology include explosives detection personnel portals, the Material Area Access (MAA) checkpoint of the future, an explosives detection vehicle portal, hand-held detection systems such as the Hound and Hound II (all 6400), micro-IMS sensors (1700), ordnance detection (2500), and Fourier Transform IMS technology (8700). The emphasis to date has been on explosives detection, but the detection of chemical agents has also been pursued (8100 and 6400).Combining Ion Mobility Spectrometry (IMS) with Mass Spectrometry (MS)The IMS-MS combination overcomes several limitations present in simple IMS systems. Ion mobility alone is insufficient to identify an unknown chemical agent. Collision cross section, upon which mobility is based, is not sufficiently unique or predictable a priori to be able to make a confident peak assignment unless the compounds present are already identified. Molecular mass, on the other hand, is much more readily interpreted and related to compounds. For a given compound, the molecular mass can be determined using a pocket calculator (or in one's head) while a reasonable value of the cross-section might require hours of computation time. Thus a mass spectrum provides chemical specificity and identity not accessible in the mobility spectrum alone. In addition, several advanced mass spectrometric methods, such as tandem MS, have been extensively developed for the purpose of molecular identification. With an appropriate mass spectrometer connected to an ion mobility spectrometer, these advanced identification methods become available, providing greater characterization capability.3 AcronymsIMSion mobility spectrometryMAAMaterial Access AreaMSmass spectrometryoaTOForthogonal acceleration time

  2. Evaluation of Gas Chromatography/Mini-IMS to Detect VOCs

    NASA Technical Reports Server (NTRS)

    Limero, Thomas; Reese, Eric; Peters, Randy; James, John T.; Billica, Roger (Technical Monitor)

    1999-01-01

    The Toxicology Laboratory at Johnson Space Center (JSC) has pioneered the use of gas chromatography-ion mobility spectrometry (GC/IMS) for measuring target volatile organic compounds (VOCs) aboard spacecraft. Graseby Dynamics, under contract to NASA/Wyle, has built several volatile organic analyzers (VOA) based on GC/IMS. Foremost among these have been the volatile organic analyzer-risk mitigation unit and the two flight VOA units for International Space Station (ISS). The development and evaluation of these instruments has been chronicled through presentations at the International Conference on Ion Mobility Spectrometry over the past three years. As the flight VOA from Graseby is prepared for operation on ISS at JSC, it is time to begin evaluations of technologies for the next generation VOA, Although the desired instrument characteristics for the next generation unit are the same as the current unit, the requirements are much more stringent. As NASA looks toward future missions beyond Earth environs, a premium will be placed upon small, light, reliable, autonomous hardware. It is with these visions in mind that the JSC Toxicology Laboratory began a search for the next generation VOA. One technology that is a candidate for the next generation VOA is GC/IMS. The recent miniaturization of IMS technology permits it to compete with other, inherently small, technologies such as chip-sized sensor arrays. This paper will discuss the lessons learned from the VOA experience and how that has shaped the design of a potential second generation VOA based upon GC/IMS technology. Data will be presented from preliminary evaluations of GC technology and the mini-IMS when exposed to VOCs likely to be detected aboard spacecraft. Results from the evaluation of an integrated GC/mini-IMS system will be shown if available.

  3. Vergleich von rekombinanten Vaccinia- und DNA-Vektoren zur Tumorimmuntherapie im C57BL/6-Mausmodell

    NASA Astrophysics Data System (ADS)

    Johnen, Heiko

    2002-10-01

    In der vorliegenden Arbeit wurden Tumorimpfstoffe auf der Basis des Plasmid-Vektors pCI, modified vaccinia virus Ankara (MVA) und MVA-infizierten dendritischen Zellen entwickelt und durch Sequenzierung, Western blotting und durchflußzytometrische Analyse überprüft. Die in vivo Wirksamkeit der Vakzinen wurde in verschiedenen Tumormodellen in C57BL/6 Mäusen verglichen. Die auf dem eukaryotischen Expressionsvektor pCI basierende DNA-Vakzinierung induzierte einen sehr wirksamen, antigenspezifischen und langfristigen Schutz vor Muzin, CEA oder beta-Galactosidase exprimierenden Tumoren. Eine MVA-Vakzinierung bietet in den in dieser Arbeit durchgeführten Tumormodellen keinen signifikanten Schutz vor Muzin oder beta-Galactosidase exprimierenden Tumoren. Sowohl humane, als auch murine in vitro generierte dendritische Zellen lassen sich mit MVA – im Vergleich zu anderen viralen Vektoren – sehr gut infizieren. Die Expressionsrate der eingefügten Gene ist aber gering im Vergleich zur Expression in permissiven Wirtszellen des Virus (embryonale Hühnerfibroblasten). Es konnte gezeigt werden, daß eine MVA-Infektion dendritischer Zellen ähnliche Auswirkungen auf den Reifezustand humaner und muriner dendritischer Zellen hat, wie eine Infektion mit replikationskompetenten Vakzinia-Stämmen, und außerdem die Hochregulation von CD40 während der terminalen Reifung von murinen dendritischen Zellen inhibiert wird. Die während der langfristigen in vitro Kultur auf CEF-Zellen entstandenen Deletionen im MVA Genom führten zu einer starken Attenuierung und dem Verlust einiger Gene, die immunmodulatorische Proteine kodieren, jedoch nicht zu einer Verminderung des zytopathischen Effekts in dendritischen Zellen. Die geringe Expressionsrate und die beobachtete Inhibition der Expression kostimulatorischer Moleküle auf dendritischen Zellen kann für eine wenig effektive Induktion einer Immunantwort in MVA vakzinierten Tieren durch cross priming oder die direkte Infektion

  4. IMS/Satellite Situation Center report. Special IMS periods for 1976

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Special International Magnetospheric Study (IMS) Satellite Periods selected at times when two or more satellites are expected to be in interesting regions of the magnetosphere simultaneously are described. Data are presented to aid in defining a program of magnetospheric observations which emphasizes coordinated measurements of satellites, rockets, balloons, aircraft, and ground-based stations. The position is given of currently operating high altitude spacecraft in the Geocentric Solar Ecliptic, Geocentric Solar Magnetospheric, and Solar Magnetic coordinate systems to determine their passage through the bow shock, the magnetopause, the cusp, or the neutral sheet region. Information on the synchronous and low altitude spacecraft and experiments are included in tabular form along with a tabular summary of all the rocket, balloon, and aircraft campaigns in 1976.

  5. Peste des petits ruminants

    PubMed Central

    Parida, S.; Muniraju, M.; Mahapatra, M.; Muthuchelvan, D.; Buczkowski, H.; Banyard, A.C.

    2015-01-01

    Peste des petits ruminants virus causes a highly infectious disease of small ruminants that is endemic across Africa, the Middle East and large regions of Asia. The virus is considered to be a major obstacle to the development of sustainable agriculture across the developing world and has recently been targeted by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation (FAO) for eradication with the aim of global elimination of the disease by 2030. Fundamentally, the vaccines required to successfully achieve this goal are currently available, but the availability of novel vaccine preparations to also fulfill the requisite for differentiation between infected and vaccinated animals (DIVA) may reduce the time taken and the financial costs of serological surveillance in the later stages of any eradication campaign. Here, we overview what is currently known about the virus, with reference to its origin, updated global circulation, molecular evolution, diagnostic tools and vaccines currently available to combat the disease. Further, we comment on recent developments in our knowledge of various recombinant vaccines and on the potential for the development of novel multivalent vaccines for small ruminants. PMID:26443889

  6. Direct analysis of organic priority pollutants by IMS

    NASA Technical Reports Server (NTRS)

    Giam, C. S.; Reed, G. E.; Holliday, T. L.; Chang, L.; Rhodes, B. J.

    1995-01-01

    Many routine methods for monitoring of trace amounts of atmospheric organic pollutants consist of several steps. Typical steps are: (1) collection of the air sample; (2) trapping of organics from the sample; (3) extraction of the trapped organics; and (4) identification of the organics in the extract by GC (gas chromatography), HPLC (High Performance Liquid Chromatography), or MS (Mass Spectrometry). These methods are often cumbersome and time consuming. A simple and fast method for monitoring atmospheric organics using an IMS (Ion Mobility Spectrometer) is proposed. This method has a short sampling time and does not require extraction of the organics since the sample is placed directly in the IMS. The purpose of this study was to determine the responses in the IMS to organic 'priority pollutants'. Priority pollutants including representative polycyclic aromatic hydrocarbons (PAHs), phthalates, phenols, chlorinated pesticides, and polychlorinated biphenyls (PCB's) were analyzed in both the positive and negative detection mode at ambient atmospheric pressure. Detection mode and amount detected are presented.

  7. Robust sliding mode continuous control of an IM drive

    SciTech Connect

    Jezernik, K.; Hren, A.; Drevensek, D.

    1995-12-31

    A control approach for robust trajectory tracking of IM servodrive based on the variable structure systems (VSS) is described. A new discrete-time control algorithm has been developed by combining VSS and Lyapunov design. It possesses all the good properties of the sliding mode and avoids the unnecessary discontinuity of the control input, thus eliminating chattering which has been considering as serious obstacles for applications of VSS. A unified control approach for current, torque and motion control based on the discrete-time sliding mode for application in indirect vector control of an IM drive is developed. The sliding mode approach can be applied to the control of an Im drive due to the replacement of the hysteresis controller with widely used PWM technique. All the theoretical issues are verified by experiment. The experimental system consists of a transputer and a microcontroller, thus allowing parallel processing.

  8. The Search for Polarization Variability in IM Pegasi

    NASA Astrophysics Data System (ADS)

    Berdyugin, A. V.; Berdyugina, S. V.; Piirola, V.; Butkevich, A. G.

    2006-11-01

    We have studied linear polarization in the RS CVn binary IM Pegasi in order to check the possibility that this star has variable polarization. For this purpose, accurate polarization measurements in the B, V, and R passbands with the new CCD polarimeter on the remotely operated KVA telescope at La Palma were carried out in 2005 August-November. Our observations have yielded accurate determination of the polarization in IM Peg: PB=0.064%+/-0.004%, θB=97deg+/-2deg PV=0.102%+/-0.006%, θV=91deg+/-3deg and PR=0.078%+/-0.005%, θR=95deg+/-4deg. Analysis of the data indicates no significant polarization variability in IM Peg. The upper limit for the amplitude of possible variability is <=0.03% in all passbands. In contrast to the previously published results, the linear polarization in this star is most likely nonvariable and interstellar in origin.

  9. Assessing the Peak Capacity of IMS-IMS Separations of Tryptic Peptide Ions in 300 K He

    PubMed Central

    Merenbloom, Samuel I.; Bohrer, Brian C.; Koeniger, Stormy L.; Clemmer, David E.

    2011-01-01

    Two-dimensional ion mobility spectrometry (IMS-IMS) coupled with mass spectrometry is examined as a means of separating mixtures of tryptic peptides (from myoglobin and hemoglobin). In this study we utilize two distinct drift regions that are identical in that each contains He buffer gas at 300 K. The two-dimensional advantage is realized by changing the structures of the ions. As ions arrive at the end of the first drift region, those of a specified mobility are selected, exposed to energizing collisions, and then introduced into a second drift region. Upon collisional activation some ions undergo structural transitions, leading to substantial changes in their mobilities; others undergo only slight (or no) mobility changes. Examination of peak positions and shapes for peptides that are separated in the first IMS dimension indicates experimental peak capacities ranging from ~60 to 80; the peak shapes and range of changes in mobility that are observed in the second drift region (after activation) indicates a capacity enhancement ranging from a factor of ~7 to 17. Thus, experimental (and theoretical) evaluation of the peak capacity of IMS-IMS operated in this fashion indicates that capacities of ~480 to 1360 are accessible for peptides. Molecular modeling techniques are used to simulate the range of structural changes that would be expected for tryptic peptide ions and are consistent with the experimental shifts that are observed. PMID:17222015

  10. Coordinated optical and ultraviolet observations of IM Pegasi

    SciTech Connect

    Huenemoerder, D.P.; Ramsey, L.W.; Buzasi, D.L. )

    1990-02-01

    IUE spectra and optical observations of IM Peg obtained during the summers of 1985 and 1986 are analyzed. The modulations of the UV emission lines and the H-alpha, H-beta, and the CaII IR triplet (IRT) optical lines are examined. It is observed that: the UV emissin-line modulation increases as a function of height, H-alpha variability is related to stochastic events, H-beta displays excess absorption relative to a standard star, and the Ca IRT reveals a clear modulation with phase. It is noted that IM Peg corresponds to the solar paradigm used to explain RS CVn activity. 30 refs.

  11. Coordinated optical and ultraviolet observations of IM Pegasi

    NASA Technical Reports Server (NTRS)

    Huenemoerder, David P.; Ramsey, Lawrence W.; Buzasi, Derek L.

    1990-01-01

    IUE spectra and optical observations of IM Peg obtained during the summers of 1985 and 1986 are analyzed. The modulations of the UV emission lines and the H-alpha, H-beta, and the CaII IR triplet (IRT) optical lines are examined. It is observed that: the UV emissin-line modulation increases as a function of height, H-alpha variability is related to stochastic events, H-beta displays excess absorption relative to a standard star, and the Ca IRT reveals a clear modulation with phase. It is noted that IM Peg corresponds to the solar paradigm used to explain RS CVn activity.

  12. Pulsation research during the IMS. [International Magnetospheric Study

    NASA Technical Reports Server (NTRS)

    Hughes, W. J.

    1982-01-01

    After describing the development status of the field of magnetic pulsations in 1975, before the initiation of the International Magnetospheric Study (IMS), attention is given to the IMS's novel observational results and an attempt is made to identify the most effective research methods employed. It is found that the most fruitful work involved small-scale collaboration between a few individuals or a few groups possessing complementary data sets. Consideration is restricted to research on the long period pulsations which can be broadly classified as field line resonances. Recommendations are made for future research efforts.

  13. Regelungen im Verkehr mit Lebensmitteln und Bedarfsgegenständen in Deutschland

    NASA Astrophysics Data System (ADS)

    Thomas, Gundula; Freund, Astrid; Gründig, Friedrich

    Im Zuge der Globalisierung von Produktion und Handel ändert sich auch der Charakter der Vorschriften im Lebensmittelrecht. Zunehmend treten internationale Rechtsbestimmungen, Abkommen, Standards und andere Normen an die Stelle nationaler Regelungen.

  14. Classification of 20 DES Supernova with OzDES

    NASA Astrophysics Data System (ADS)

    Davis, T. M.; Kim, A. G.; Macualay, E.; Lidman, C.; Sharp, R.; Tucker, B. E.; Yuan, F.; Zhang, B.; Lewis, G. F.; Sommer, N. E.; Martini, P.; Mould, J.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Foley, R. J.; Pan, Y.-C.; Casas, R.; Castander, F. J.; Desai, S.; Paech, K.; Smith, R. C.; Schubnell, M.; Kessler, R.; Lasker, J.; Scolnic, D.; Brout, D. J.; Gladney, L.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; Nichol, R.; Papadopoulos, A.; Childress, M.; D'Andrea, C.; Smith, M.; Sullivan, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.

    2015-12-01

    We report new spectroscopic classifications by OzDES of supernovae discovered by the Dark Energy Survey (ATEL #4668). The spectra (370-885nm) were obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT).

  15. Classification of 15 DES supernovae by OzDES

    NASA Astrophysics Data System (ADS)

    Yuan, F.; Tucker, B. E.; Lidman, C.; Martini, P.; Gshwend, Julia; Moller, A.; Zhang, B.; Smith, R. C.; Schubnell, M.; Kessler, R.; Lasker, J.; Scolnic, D.; Brout, D. J.; Gladney, L.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; Nichol, R.; Papadopoulos, A.; Childress, M.; D'Andrea, C.; Smith, M.; Sullivan, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Kim, A. G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Foley, R. J.; Pan, Y.-C.; Casas, R.; Castander, F. J.; Desai, S.; Paech, K.

    2015-12-01

    We report new spectroscopic classifications by OzDES of supernovae discovered by the Dark Energy Survey (ATEL #4668). The spectra (370-885nm) were obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT).

  16. Classification of 3 DES Supernovae with OzDES

    NASA Astrophysics Data System (ADS)

    Moller, A.; Tucker, B. E.; Yuan, F.; Lewis, G.; Lidman, C.; Macaulay, E.; Nichol, R.; Papadopoulos, A.; Childress, M.; D'Andrea, C.; Smith, M.; Sullivan, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Kim, A. G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Foley, R. J.; Pan, Y.-C.; Casas, R.; Castander, F. J.; Desai, S.; Paech, K.; Smith, R. C.; Schubnell, M.; Kessler, R.; Lasker, J.; Scolnic, D.; Brout, D. J.; Gladney, L.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.

    2016-02-01

    We report new spectroscopic classifications by OzDES of supernovae discovered by the Dark Energy Survey (ATEL #4668). The spectra (370-885nm) were obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT).

  17. Classification of 4 DES supernovae by OzDES

    NASA Astrophysics Data System (ADS)

    Glazebrook, K.; Amon, A.; Lidman, C.; Martini, P.; Tucker, B. E.; Yuan, F.; Aldering, G.; Kim, A. G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Foley, R. J.; Pan, Y.-C.; Casas, R.; Castander, F. J.; Desai, S.; Paech, K.; Smith, R. C.; Schubnell, M.; Kessler, R.; Lasker, J.; Scolnic, D.; Brout, D. J.; Gladney, L.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; Nichol, R.; Papadopoulos, A.; Childress, M.; D'Andrea, C.; Smith, M.; Sullivan, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.

    2015-12-01

    We report new spectroscopic classifications by OzDES of supernovae discovered by the Dark Energy Survey (ATEL #4668). The spectra (370-885nm) were obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT).

  18. Classification of 6 DES Supernova with OzDES

    NASA Astrophysics Data System (ADS)

    Lewis, G. F.; Mould, J.; Lidman, C.; Tucker, B. E.; Sharp, R.; Yuan, F.; Martini, P.; Kessler, R.; Scolnic, D.; Covarrubias, R. A.; Brout, D. J.; Fischer, J. A.; Gladney, L.; March, M.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; Nichol, R.; Papadopoulos, A.; D'Andrea, C.; Smith, M.; Sullivan, M.; Childress, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Kim, A. G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Foley, R. J.; Casas, R.; Castander, F. J.; Desai, S.; Paech, K.; Smith, R. C.; Schubnell, M.

    2015-10-01

    We report new spectroscopic classifications by OzDES of supernovae discovered by the Dark Energy Survey (ATEL #4668). The spectra (370-885nm) were obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT).

  19. Classification of 14 DES Supernova with OzDES

    NASA Astrophysics Data System (ADS)

    Tucker, B. E.; Sharp, R.; Yuan, F.; Zhang, B.; Lidman, C.; Davis, T. M.; Hinton, S.; Mould, J.; Smith, R. C.; Schubnell, M.; Kessler, R.; Scolnic, D.; Covarrubias, R. A.; Brout, D. J.; Fischer, J. A.; Gladney, L.; March, M.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; Nichol, R.; Papadopoulos, A.; D'Andrea, C.; Smith, M.; Sullivan, M.; Childress, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Kim, A. G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Foley, R. J.; Castander, F. J.; Desai, S.; Paech, K.

    2015-10-01

    We report new spectroscopic classifications by OzDES of supernovae discovered by the Dark Energy Survey. The spectra (370-885nm) were obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT).

  20. The Education of Children in Im/Migrant Families

    ERIC Educational Resources Information Center

    Arzubiaga, Angela E.; Nogueron, Silvia C.; Sullivan, Amanda L.

    2009-01-01

    The numbers of im/migrant children in schools have increased throughout the world. The principal receiving areas are North America, Western Europe, the Persian Gulf, Asia and the Pacific, and the Southern Cone of South America. In the United States, one out of every four children younger than the age of 8 lives in a family where at least one…

  1. OPSCAN 100, Scan Tape Preparation for IMS Runs.

    ERIC Educational Resources Information Center

    Cooper, Pamela

    An Opscan 100 optical scanner was used to score test materials received at the Southwest Regional Laboratory (SWRL) during the tryout of SWRL's Instructional Management System (IMS). This document describes the functional characteristics of the optical scanner. Directions for preparing two types of control forms processed by the scanner and…

  2. IMS Version 3 Student Data Base Maintenance Program.

    ERIC Educational Resources Information Center

    Brown, John R.

    Computer routines that update the Instructional Management System (IMS) Version 3 student data base which supports the Southwest Regional Laboratory's (SWRL) student monitoring system are described. Written in IBM System 360 FORTRAN IV, the program updates the data base by adding, changing and deleting records, as well as adding and deleting…

  3. Industrial Maintenance Technology (IM-TEC). Student Manual.

    ERIC Educational Resources Information Center

    Fusch, Gene E.

    This student manual explains an innovative strategy through which Bellingham Technical College's (Washington) evening Industrial Electrician and Millwright Apprenticeships were aggregated with workforce upgrade course offerings to form the college's first evening degree program in Industrial Maintenance Technology (IM-TEC). Section 1 contains a…

  4. Criteria Underlying the Formation of Alternative IMS Configurations.

    ERIC Educational Resources Information Center

    Dave, Ashok

    To assist the formation of IMS (Instructional Management System) configurations, three categories of characteristics are developed and explained. Categories 1 and 2 emphasize automation, and the necessity of forming workable configurations to carry out instructional management for Southwest Regional Laboratory developed instructional and/or…

  5. VLBI for Gravity Probe B: the guide star, IM Pegasi

    NASA Astrophysics Data System (ADS)

    Bartel, N.; Bietenholz, M. F.; Lebach, D. E.; Ransom, R. R.; Ratner, M. I.; Shapiro, I. I.

    2015-11-01

    We review the radio very long baseline interferometry (VLBI) observations of the guide star, IM Peg, and three compact extragalactic reference sources, made in support of the NASA/Stanford gyroscope relativity mission, Gravity Probe B (GP-B). The main goal of the observations was the determination of the proper motion of IM Peg relative to the distant Universe. VLBI observations made between 1997 and 2005 yield a proper motion of IM Peg of -20.83 ± 0.09 mas yr-1 in α and -27.27 ± 0.09 mas yr-1 in δ in a celestial reference frame of extragalactic radio galaxies and quasars virtually identical to the International Celestial Reference Frame 2 (ICRF2). They also yield a parallax for IM Peg of 10.37 ± 0.07 mas, corresponding to a distance of 96.4 ± 0.7 pc. The uncertainties are standard errors with statistical and estimated systematic contributions added in quadrature. These results met the pre-launch requirements of the GP-B mission to not discernibly degrade the estimates of the geodetic and frame-dragging effects.

  6. Adolescent Subtest Norms for the ImPACT Neurocognitive Battery.

    PubMed

    Henry, Luke C; Sandel, Natalie

    2015-01-01

    The neurocognitive testing of sports concussion for injury management and return-to-play decisions has long been considered the gold standard in evaluation of the injury. Computerized testing batteries are frequently employed, with the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) being the most used of all the current testing platforms to evaluate concussion. ImPACT's clinical report yields four normed composite scores (Verbal Memory, Visual Memory, Visual Motor Speed, and Reaction Time) and another composite score that is not normed but is used as a validity measure (Impulse Control), as well as their corresponding subtest scores, which are not normed. The current study provides normative data on each of the subtests used to calculate the composite scores. Normative data are separated by gender for athletes aged 13 to 21 years old and are stratified by the norm age brackets already employed by the ImPACT. These norms may be helpful in the interpretation of the ImPACT clinical report and further delineation of areas of neurocognitive dysfunction. PMID:25412432

  7. Static corrections for enhanced signal detection at IMS seismic arrays

    NASA Astrophysics Data System (ADS)

    Wilkins, Neil; Wookey, James; Selby, Neil

    2016-04-01

    Seismic monitoring forms an important part of the International Monitoring System (IMS) for verifying the Comprehensive nuclear Test Ban Treaty (CTBT). Analysis of seismic data can be used to discriminate between nuclear explosions and the tens of thousands of natural earthquakes of similar magnitude that occur every year. This is known as "forensic seismology", and techniques include measuring the P-to-S wave amplitude ratio, the body-to-surface wave magnitude ratio (mb/Ms), and source depth. Measurement of these seismic discriminants requires very high signal-to-noise ratio (SNR) data, and this has led to the development and deployment of seismic arrays as part of the IMS. Array processing methodologies such as stacking can be used, but optimum SNR improvement needs an accurate estimate of the arrival time of the particular seismic phase. To enhance the imaging capability of IMS arrays, we aim to develop site-specific static corrections to the arrival time as a function of frequency, slowness and backazimuth. Here, we present initial results for the IMS TORD array in Niger. Vespagrams are calculated for various events using the F-statistic to clearly identify seismic phases and measure their arrival times. Observed arrival times are compared with those predicted by 1D and 3D velocity models, and residuals are calculated for a range of backazimuths and slownesses. Finally, we demonstrate the improvement in signal fidelity provided by these corrections.

  8. The (Im)possibility of the Project: Radford Address

    ERIC Educational Resources Information Center

    Green, Bill

    2010-01-01

    In this address, the author engages both with the possibility "and" the impossibility of the educational project--and suggests something of what it means to say this. His presentation is specifically addressed to the theme of the (im)possibility of the educational project. He draws from philosophy, literature, psychoanalysis and history, as well…

  9. IM Set to Talk with You with Text!

    ERIC Educational Resources Information Center

    Descy, Don E.

    2007-01-01

    In this article, the author discusses text messaging and instant messaging (IM). In a nutshell, text messaging is another name for Short Message Service (SMS). SMS is a service available on most digital mobile phones that permits the sending of short messages (also known as SMSes, text messages, messages, or more colloquially texts or even txts)…

  10. Choosing the Right Free IM Providers and Clients for Your Library

    ERIC Educational Resources Information Center

    Izenstark, Amanda K.

    2009-01-01

    With virtual library services increasing, public services librarians may find themselves with questions such as: What instant messaging services (IM) are available? Which IM service would best suit my patrons' needs? Which IM service best suits my library's technology profile? This column describes the features and functionality of major instant…

  11. Overview of the IMS Version 3 Computer Software Considerations in the 1971-72 System Exercise.

    ERIC Educational Resources Information Center

    Wolfe, Howard

    Hardware and software components employed in the 1971-72 tryout of a research-based, computer-operated Instructional Management System (IMS) are listed and described. Purposes of the tryout are given, and the communications system detailed. Source-input and output documents are listed, along with the IMS computer programs and IMS files.…

  12. ImERSE (Improving Experience through Regular Shadowing Events)

    PubMed Central

    Calvert, William; Minford, Joanne; Platt, Carol; Chatfield, Catriona

    2015-01-01

    Systematic operational quality improvement strategies within the NHS are hard to find, although there are numerous published reports of sporadic departmental models and methods resulting in improvements in clinical care. We describe the experience of devising a tool to provide large data collection of patient care experiences by using medical students to shadow patient journeys. This combines patient and family centred care (PFCC) and quality improvement approaches to create a systematic organisational strategy for improving care. The ImERSE (improving experience through regular shadowing events) approach could be applied to any area of health care to generate population specific improvement priorities. It can be used to promote patient and family centred care and provide a unique medical education experience. We describe its evolution in its first year of use and suggest that using the ImERSE approach delivers beneficial characteristics to patients and their families, those undergoing a shadowing experience, and provider organisations. PMID:26734410

  13. Cosmic Shear Measurements with DES Science Verification Data

    SciTech Connect

    Becker, M. R.

    2015-07-20

    We present measurements of weak gravitational lensing cosmic shear two-point statistics using Dark Energy Survey Science Verification data. We demonstrate that our results are robust to the choice of shear measurement pipeline, either ngmix or im3shape, and robust to the choice of two-point statistic, including both real and Fourier-space statistics. Our results pass a suite of null tests including tests for B-mode contamination and direct tests for any dependence of the two-point functions on a set of 16 observing conditions and galaxy properties, such as seeing, airmass, galaxy color, galaxy magnitude, etc. We use a large suite of simulations to compute the covariance matrix of the cosmic shear measurements and assign statistical significance to our null tests. We find that our covariance matrix is consistent with the halo model prediction, indicating that it has the appropriate level of halo sample variance. We also compare the same jackknife procedure applied to the data and the simulations in order to search for additional sources of noise not captured by the simulations. We find no statistically significant extra sources of noise in the data. The overall detection significance with tomography for our highest source density catalog is 9.7σ. Cosmological constraints from the measurements in this work are presented in a companion paper (DES et al. 2015).

  14. 12 CFR 404.35 - Procedures for requests for Ex-Im Bank employees to provide expert or opinion testimony.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Procedures for requests for Ex-Im Bank... OF THE UNITED STATES INFORMATION DISCLOSURE Demands for Testimony of Current and Former Ex-Im Bank Personnel and for Production of Ex-Im Bank Records § 404.35 Procedures for requests for Ex-Im Bank...

  15. 12 CFR 404.35 - Procedures for requests for Ex-Im Bank employees to provide expert or opinion testimony.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Procedures for requests for Ex-Im Bank... OF THE UNITED STATES INFORMATION DISCLOSURE Demands for Testimony of Current and Former Ex-Im Bank Personnel and for Production of Ex-Im Bank Records § 404.35 Procedures for requests for Ex-Im Bank...

  16. Achieving E-learning with IMS Learning Design--Workflow Implications at the Open University of the Netherlands

    ERIC Educational Resources Information Center

    Westera, Wim; Brouns, Francis; Pannekeet, Kees; Janssen, Jose; Manderveld, Jocelyn

    2005-01-01

    This paper uses the Open University of the Netherlands as an instructive case for the introduction of e-learning based on the IMS Learning Design specification (IMS LD). The IMS LD specification, as approved by the IMS Global Learning Consortium in 2003, enables the specification and encoding of learning scenarios that describe any design of a…

  17. ImSET: Impact of Sector Energy Technologies

    SciTech Connect

    Roop, Joseph M.; Scott, Michael J.; Schultz, Robert W.

    2005-07-19

    This version of the Impact of Sector Energy Technologies (ImSET) model represents the ''next generation'' of the previously developed Visual Basic model (ImBUILD 2.0) that was developed in 2003 to estimate the macroeconomic impacts of energy-efficient technology in buildings. More specifically, a special-purpose version of the 1997 benchmark national Input-Output (I-O) model was designed specifically to estimate the national employment and income effects of the deployment of Office of Energy Efficiency and Renewable Energy (EERE) -developed energy-saving technologies. In comparison with the previous versions of the model, this version allows for more complete and automated analysis of the essential features of energy efficiency investments in buildings, industry, transportation, and the electric power sectors. This version also incorporates improvements in the treatment of operations and maintenance costs, and improves the treatment of financing of investment options. ImSET is also easier to use than extant macroeconomic simulation models and incorporates information developed by each of the EERE offices as part of the requirements of the Government Performance and Results Act.

  18. Annuaire du Bureau des longitudes - 2006

    NASA Astrophysics Data System (ADS)

    Imcce; Bureau Des Longitudes

    2005-07-01

    This annual publication provides ephemerides and data to the use of professionnal and amateur astronomers. Divided in 11 chapters it covers concordance of various calendars, explanation of fondamental astronomy and various time scales, explanation for the use of ephemerides; tables provide ephemerides (positions, rise/set/passage) of the Sun and the Moon, planets, planetary satellites, asteroids, comets, bright stars; data and explanation for the physical observation of the surface of the Sun, the Moon, and planets; chart of the sky and a list of constellations and galaxies; prediction and ephemerides for astronomical phenomenon: occultation by the moon, stellar occultations by asteroids and appulses, solar eclipses and lunar eclipses; and an additional review about a hot scientific topic, this year: "Legendre et le méridien terrestre, 200 ans après". Cette publication annuelle fournit des éphémérides et des données à l'usage des astronomes professionnels et des astronomes amateurs. Composée de 11 chapitres elle comprend les rubriques sur les différents calendriers et leurs concordance, les fêtes légales en France, les dates et décrets sur les heures légales en France métropolitaine ; une introduction à l'astronomie fondamentale et aux différentes échelles de temps, des explications sur l'utilisation des éphémérides ; des tables fournissent les éphémérides (positions, heures de lever/coucher/passage) du Soleil et de la Lune, de planètes, de satellites naturels, d'astéroïdes, de comètes, d'étoiles brillantes ; des données pour l'observation de la surface du Soleil, de la Lune, et des planètes ; des cartes du ciel ainsi qu'une liste de constellations et de galaxies ; des prédictions des phénomènes astronomiques : occultation par la Lune, occultation stellaires par des astéroïdes et appulses, éclipses de Soleil et de la Lune; la liste et les coordonnées des observatoires astronomiques les plus connus ; et enfin un cahier th

  19. Zum Problem des Tests, insbesondere des Einstufungstests, im Deutschunterricht fuer Auslaender (On the Problem of Tests, Particularly Placement Tests, in Teaching German to Foreigners)

    ERIC Educational Resources Information Center

    Breitung, H. A.; And Others

    1974-01-01

    New placement procedure at Humboldt University includes interviews and placement tests. Interviews reveal response ability, tempo, pronunciation, comprehension, etc. The 60-minute test that follows is described and results discussed, as well as difficulty level and grading. Results: better grouping of students, less shifting, better work. (Text is…

  20. Transport quantique dans des nanostructures

    NASA Astrophysics Data System (ADS)

    Naud, C.

    2002-09-01

    structure des oscillations de conductance en fonction du flux du champ magnétique de période h/e dont l'amplitude est beaucoup plus importante que celle mesurée sur un réseau carré de même dimension. Cette différence constitue une signature d'un effet de localisation induit par le champ magnétique sur la topologie mathcal{T}3. Pour des valeurs spécifiques du champ magnétique, du fait des interférences destructives Aharonov-Bohm, la propagation des fonctions d'ondes est limitée à un ensemble fini de cellule du réseau appelé cage. De la dépendance en température des oscillations de période h/e mesurées sur le réseau mathcal{T}3 nous avons tiré une longueur caractéristique qui peut être rattachée au périmètre des cages. Un phénomène inattendu fut l'observation, pour des champs magnétiques plus importants, d'un doublement de fréquence des oscillations. Ces oscillations de période h/2e pouvant avoir une amplitude supérieure aux oscillations de période h/e, une interprétation en terme d'harmonique n'est pas possible. Enfin, l'influence de la largeur électrique des fils constituant le réseau et donc celle du nombre de canaux par brin a été étudiée en réalisant des grilles électrostatique. Les variations de l'amplitude des signaux en h/e et h/2e en fonction de la tension de grille ont été mesurés.

  1. Ländliche Entwicklung durch erneuerbare Energien - Das Beispiel Photovoltaik in Niederbayern

    NASA Astrophysics Data System (ADS)

    Zink, Roland

    2013-09-01

    Der Ausbau erneuerbarer Energien ist in Deutschland eine zentrale und politisch konsensfähige Forderung, um die Energieversorgung klimafreundlich und nachhaltig zu gestalten. Speziell ländliche Regionen rücken dabei in den Fokus, bieten sie doch aufgrund ihrer hohen Flächenverfügbarkeit große Potenziale für die flächenintensiven dezentralen Energieformen. Folglich erkennen Kommunen zunehmend das Entwicklungspotenzial dieser Technologien und sehen sie auch als Chance, neue wirtschaftliche Impulse vor Ort zu setzen. Der Beitrag skizziert die rasante Entwicklung der Photovoltaik im Regierungsbezirk Niederbayern und diskutiert anhand des Beispiels die Folgen für eine nachhaltige Regionalentwicklung.

  2. Zur Darstellung von Synchronie und Diachronie des Vokalismus im Deutschen (On the Synchronic and Diachronic Representation of Vocalization in German)

    ERIC Educational Resources Information Center

    Pauly, Peter

    1974-01-01

    A combination matrix could be very useful to illustrate the synchronic and diachronic representation of German diphthongs. Examples are provided. It is further suggested that such a matrix could be utilized for phonological research in the areas of historical linguistics, sociolinguistics and dialectology. (Text is in German.) (DS)

  3. Lichtkurve und Periode des RR-Lyrae-Sterns TV Trianguli und GSC 02297-00060, ein neuer Veraenderlicher im Feld

    NASA Astrophysics Data System (ADS)

    Groebel, Rainer

    2014-03-01

    Based on data from the SWASP database and on recent observations 21 maxima and 12 minima timings of the little studied star TV Tri could be derived. It is shown that since the discovery the period remains essentially constant. The light curve shows only slight variations with a hump in the ascending branch. An improved ephemeris HJD (max.) = 2447385.354(5) + 0.7057324(5) x E is given. It turned out that the nearby suspected variable NSV 15327 (GSC 2.3 NBXY006220, 1:33:24.96 +32:27:39.10) remained constant in the observation period. It could be shown that the star GSC 02297-00060 (1:32:54.08 +32:29:34.85) also present in the field, is a short period eclipsing variable with shallow eclipses of 0.1 mag amplitude with the ephemeris HJD (min.) = 2456220.5180(16) + 0.2556919(14) x E. Rainer Groebel is a member of the BAV.

  4. Eigenschaften geothermischer Nutzhorizonte im baden-württembergischen und französischen Teil des Oberrheingrabens

    NASA Astrophysics Data System (ADS)

    Stober, I.; Jodocy, M.

    2009-06-01

    The project entitled „Development of an Internet Based Geothermal System for Germany” includes the design of a geothermal information system for the deep hydrogeothermal resources of Germany. For the first time, hydraulic data from the entire Upper Rhine Graben in Baden-Württemberg and France were collected and interpreted. They give hydraulic conductivities in the geothermal reservoirs of the Hauptrogenstein, Oberer Muschelkalk and Buntsandstein. The mean value of the Hauptrogenstein south of Freiburg is T/H = 1,8 · 10-6 m/s, and the Oberer Muschelkalk average is T/H = 2,0 · 10-6 m/s. For the Buntsandstein, the hydraulic conductivity is T/H > 2,4 · 10-7 m/s. Estimated hydraulic conductivities derived from productivity indices and permeability data are used for further comparative considerations.

  5. Building Adaptive Game-Based Learning Resources: The Integration of IMS Learning Design and

    ERIC Educational Resources Information Center

    Burgos, Daniel; Moreno-Ger, Pablo; Sierra, Jose Luis; Fernandez-Manjon, Baltasar; Specht, Marcus; Koper, Rob

    2008-01-01

    IMS Learning Design (IMS-LD) is a specification to create units of learning (UoLs), which express a certain pedagogical model or strategy (e.g., adaptive learning with games). However, the authoring process of a UoL remains difficult because of the lack of high-level authoring tools for IMS-LD, even more so when the focus is on specific topics,…

  6. "Das Konkrete ist das Abstrakte, an das man sich schließlich gewöhnt hat." (Laurent Schwartz) Über den Ablauf des mathematischen Verstehens

    NASA Astrophysics Data System (ADS)

    Lowsky, Martin

    Die im Titel genannte Aussage findet sich in den Lebenserinnerungen von Laurent Schwartz (1915-2002), einem der fruchtbarsten Mathematiker, Mitglied der Gruppe Bourbaki. Im Original lautet die Aussage: "un objet concret est un objet abstrait auquel on a fini par s'habituer." Schwartz erläutert sie am Beispiel des Integrals über {e^{-1/2{x^2}}} , das den Wert Wurzel aus 2π hat und in dem sich also die Zahlen e und π verknüpfen. Was Schwartz aber vor allem ausdrücken will, ist dies: Das mathematische Verständnisd geht langsam vor sich und es bedarf der Anstrengung. "Es ist eine Frage der Zeit und der Energie", sagt Schwartz, und gerade dies mache es so schwer, die höhere Mathematik unter das Volk zu bringen. Das Lernen und Lehren von Mathematik laufe eben mühevoll und langsam ab.

  7. ImBuild: Impact of building energy efficiency programs

    SciTech Connect

    Scott, M.J.; Hostick, D.J.; Belzer, D.B.

    1998-04-01

    As part of measuring the impact of government programs on improving the energy efficiency of the Nation`s building stock, the Department of Energy Office of Building Technology, State and Community Programs (BTS) is interested in assessing the economic impacts of its portfolio of programs, specifically the potential impact on national employment and income. The special-purpose version of the IMPLAN model used in this study is called ImBuild. In comparison with simple economic multiplier approaches, such as Department of Commerce RIMS 2 system, ImBuild allows for more complete and automated analysis of the economic impacts of energy efficiency investments in buildings. ImBuild is also easier to use than existing macroeconomic simulation models. The authors conducted an analysis of three sample BTS energy programs: the residential generator-absorber heat exchange gas heat pump (GAX heat pump), the low power sulfur lamp (LPSL) in residential and commercial applications, and the Building America program. The GAX heat pump would address the market for the high-efficiency residential combined heating and cooling systems. The LPSL would replace some highly efficient fluorescent commercial lighting. Building America seeks to improve the energy efficiency of new factory-built, modular, manufactured, and small-volume, site-built homes through use of systems engineering concepts and early incorporation of new products and processes, and by increasing the demand for more energy-efficient homes. The authors analyze a scenario for market penetration of each of these technologies devised for BTS programs reported in the BTS GPRA Metrics Estimates, FY99 Budget Request, December 19, 1997. 46 figs., 4 tabs.

  8. ODE/IM correspondence and modified affine Toda field equations

    NASA Astrophysics Data System (ADS)

    Ito, Katsushi; Locke, Christopher

    2014-08-01

    We study the two-dimensional affine Toda field equations for affine Lie algebra gˆ modified by a conformal transformation and the associated linear equations. In the conformal limit, the associated linear problem reduces to a (pseudo-)differential equation. For classical affine Lie algebra gˆ, we obtain a (pseudo-)differential equation corresponding to the Bethe equations for the Langlands dual of the Lie algebra g, which were found by Dorey et al. in study of the ODE/IM correspondence.

  9. The measurements of Prognoz-4, -5, -6, -7 during IMS

    NASA Astrophysics Data System (ADS)

    Galeev, A. A.

    1984-09-01

    During the International Magnetospheric Study (IMS) from 1975 to 1978 four satellites of the Prognoz series were launched, equipped with scientific instruments for measuring plasma and magnetic fields in the near-earth and interplanetary space as well as solar electromagnetic and corpuscular radiation. The paper describes the modes of plasma and field measurements of these satellites. The paper gives also a brief review of original results on plasmasphere heating, ion composition of the plasma mantle and penetration of solar wind plasma into the magnetosphere.

  10. PREFACE: 3rd International Meeting on Silicene (IMS-3)

    NASA Astrophysics Data System (ADS)

    Kara, Abdelkader; Enriquez, Hanna; Lemaire, Jean Louis; Oughaddou, Hamid

    2014-03-01

    Silicene, the new supernova material Silicon is formed in a large amount during supernova nucleo-synthesis and it is the 8th most common chemical element in the universe. Today modern electronics make large use of bulk silicon, which has consequently an extremely large impact on the world industry and economy. The need for more powerful, faster and less energy-consuming integrated circuits requires in the future the use of nanotechnologies. The ultimate step concerning silicon is silicene (the 2D silicon-based analogue of graphene). This material is of paramount importance as it requires the use of the same technologies and production lines as silicon. Even if theoreticians had predicted its possible existence, it is only in 2010 that a team of pioneers from CINAM-France, ISMO-France and UCF-USA has presented for the first time the experimental evidence of the formation of silicene. Since then research is exploding (like a supernova!) both on the experimental and theoretical sides, with the main aim of replacing bulk silicon with this potentially revolutionary material. However, before any possible industrial use, it has first to be prepared or synthesized in various stripe and sheet shapes on insulating surfaces on which its physical and chemical properties have to be analyzed in detail. A second step is its chemical functionalization through various dopants to achieve different tasks, expected or not yet imagined. Chemists and physicists, experimentalists and theoreticians are involved in this thrilling work. A wide array of techniques, from the subtle chemistry reaction networks, to all those of experimental surface science (from synchrotron radiation to scanning tunneling microscopy) as well as those of theoretical chemistry (from {\\it ab initio} to density functional theory calculations) are involved. Big progress has been made since 2010 and the success of this third International Meeting on Silicene (IMS-3) is demonstrated by the present proceedings

  11. Aberrant phenotype and transcriptome expression during fiber cell wall thickening caused by the mutation of the Im gene in immature fiber (im) mutant in Gossypium hirsutum L

    PubMed Central

    2014-01-01

    Background The immature fiber (im) mutant of Gossypium hirsutum L. is a special cotton fiber mutant with non-fluffy fibers. It has low dry weight and fineness of fibers due to developmental defects in fiber secondary cell wall (SCW). Results We compared the cellulose content in fibers, thickness of fiber cell wall and fiber transcriptional profiling during SCW development in im mutant and its near-isogenic wild-type line (NIL) TM-1. The im mutant had lower cellulose content and thinner cell walls than TM-1 at same fiber developmental stage. During 25 ~ 35 day post-anthesis (DPA), sucrose content, an important carbon source for cellulose synthesis, was also significantly lower in im mutant than in TM-1. Comparative analysis of fiber transcriptional profiling from 13 ~ 25 DPA indicated that the largest transcriptional variations between the two lines occurred at the onset of SCW development. TM-1 began SCW biosynthesis approximately at 16 DPA, whereas the same fiber developmental program in im mutant was delayed until 19 DPA, suggesting an asynchronous fiber developmental program between TM-1 and im mutant. Functional classification and enrichment analysis of differentially expressed genes (DEGs) between the two NILs indicated that genes associated with biological processes related to cellulose synthesis, secondary cell wall biogenesis, cell wall thickening and sucrose metabolism, respectively, were significantly up-regulated in TM-1. Twelve genes related to carbohydrate metabolism were validated by quantitative reverse transcription PCR (qRT-PCR) and confirmed a temporal difference at the earlier transition and SCW biosynthesis stages of fiber development between TM-1 and im mutant. Conclusions We propose that Im is an important regulatory gene influencing temporal differences in expression of genes related to fiber SCW biosynthesis. This study lays a foundation for cloning the Im gene, elucidating molecular mechanism of fiber SCW development and further

  12. Etude des effets du martelage repetitif sur les contraintes residuelles

    NASA Astrophysics Data System (ADS)

    Hacini, Lyes

    L'assemblage par soudage peut engendrer des contraintes residuelles. Ces contraintes provoquent des fissurations prematurees et un raccourcissement de la duree de vie des composants. Dans ce contexte, le martelage robotise est utilise pour relaxer ces contraintes residuelles. Trois volets sont presentes: le premier est l'evaluation des effets des impacts unitaires repetes sur le champ de contraintes developpe dans des plaques d'acier inoxydable austenitique 304L vierges ou contenant des contraintes residuelles initiales. Dans la deuxieme partie de ce projet, le martelage est applique grace au robot SCOMPI. Les contraintes residuelles induites et relaxees par martelage sont ensuite mesurees par la methode des contours, qui a ete adaptee a cet effet. Dans la troisieme partie, le martelage est modelise par la methode des elements finis. Un modele axisymetrique developpe grace au logiciel ANSYS permet de simuler des impacts repetes d'un marteau elastique sur une plaque ayant un comportement elastoplastique.

  13. IM7/LARC(tm) MPEI-1 Polymide Composites

    NASA Technical Reports Server (NTRS)

    Hou, T. H.; Cano, R. J.; Jensen, B. J.

    1998-01-01

    LARC(Trademark) MPEI-1 (Langley Research Center(Trademark) modified phenylethynyl imide-1) phenylethynyl containing aromatic polymide, is based on the reaction of biphenyl dianhydride (BPDA), 3,4'-oxydianiline (3,4'-ODA), 1,3-bis(3-aminophenoxy)benzene (APB), 2,4,6-triaminopyrimidine (TAP) and 4-phenylethynyl phthalic anhydride (PEPA), presumably resulting in a mixture of linear, branched and star shaped phenylethynyl containing imides which was evaluated as a matrix for high-performance composites. The poly(amid acid) solution of MPEI-1 in N-methypyrrolidinone was synthesized at 35% and 42% solids. Unidirectional prepreg was fabricated from these solutions and Hercules IM7 carbon fiber utilizing NASA- Langley's multipurpose prepreg machine. The temperature-dependent volatile depletion rates, thermal crystallization behavior and resin theology were characterized. Based on this information, a composite molding cycle was developed which yielded well consolidated, void-free laminates. Composite mechanical properties such as short beam shear strength, longitudinal and transverse flexural strength and flexural modulus, longitudinal tensile strength and notched and unnotched compression strengths were measured at room temperature (RT) and elevated temperatures. These mechanical properties are compared with those of IM7/LARC(Trademark) PETI-5 composites.

  14. MG II h&k line diagnostics of IM Pegasi

    NASA Astrophysics Data System (ADS)

    Olah, K.; Marik, D.; Houdebine, E. R.; Dempsey, R. C.; Budding, E.

    1998-02-01

    We have analysed the Mgii h&k resonance lines of IM Peg (KII-III) on 14 high resolution IUE LWR spectra and compared the results coming from visual spectroscopic and UBV(RI)_C photometric data. The `clean' spectra (free from interstellar absorption) were modelled using a convolution of the rotational profile with a Gaussian profile, that represents macroturbulence and broadenings of other origin, the former dominating. Significant variations in the h&k line fluxes and widths were found throughout the orbital phase range. A line broadening effect is found at maximum spot visibility both in the k and h lines. The Mgii line widths increase linearly with the flux of the transition region lines as a function of rotational phase. Anticorrelations as a function of phase were found between the Mgii line fluxes and the higher temperature lines. The k line is broader than the h line, correlated with a slope greater than unity, in keeping with a greater radiation transfer effect in the k line, and a non-optically thin medium at all phases. We observe a systematic asymmetry in the ratio of the h to k line profiles at all phases. The spectral diagnostics thus suggest the appearance of a plage region on the stellar disc. We obtained new orbital elements of the IM Peg system, deriving a small, but non-zero eccentricity. The authors would like to dedicate this paper to their late referee, Dr. P.B. Byrne.

  15. Completing and sustaining IMS network for the CTBT Verification Regime

    NASA Astrophysics Data System (ADS)

    Meral Ozel, N.

    2015-12-01

    The CTBT International Monitoring System is to be comprised of 337 facilities located all over the world for the purpose of detecting and locating nuclear test explosions. Major challenges remain, namely the completion of the network where most of the remaining stations have either environmental, logistical and/or political issues to surmont (89% of the stations have already been built) and the sustainment of a reliable and state-of the-art network covering 4 technologies - seismic, infrasound , hydroacoustic and radionuclide. To have a credible and trustworthy verification system ready for entry into force of the Treaty, the CTBTO is protecting and enhancing its investment of its global network of stations and is providing effective data to the International Data Centre (IDC) and Member States. Regarding the protection of the CTBTO's investment and enhanced sustainment of IMS station operations, the IMS Division is enhancing the capabilities of the monitoring system by applying advances in instrumentation and introducing new software applications that are fit for purpose. Some examples are the development of noble gas laboratory systems to process and analyse subsoil samples, development of a mobile noble gas system for onsite inspection purposes, optimization of Beta Gamma detectors for Xenon detection, assessing and improving the efficiency of wind noise reduction systems for infrasound stations, development and testing of infrasound stations with a self-calibrating capability, and research into the use of modular designs for the hydroacoustic network.

  16. Plasma IMS Composition Measurements for Europa and Ganymede

    NASA Technical Reports Server (NTRS)

    Sittler, E.; Cooper, J.; Hartle, R.; Lipatov, A.; Mahaffy, P.; Paterson, W.; Paschalidis, N.; Coplan, M.; Cassidy, T.

    2010-01-01

    NASA and ESA are planning the joint Europa Jupiter System Mission (EJSM) to the Jupiter system with specific emphasis to Europa and Ganymede, respectively. The Japanese Space Agency is also planning an orbiter mission to explore Jupiter's magnetosphere and the Galilean satellites. For NASA's Jupiter Europa Orbiter (JEO) we are developing the 3D Ion Mass Spectrometer (IMS) with two main goals which can also be applied to the other Galilean moons, 1) measure the plasma interaction between Europa and Jupiter's magnetosphere and 2) infer the 4n surface composition to trace elemental [1] and significant isotopic levels. The first goal supports the magnetometer (MAG) measurements, primarily directed at detection of Europa's sub-surface ocean, while the second gives information about transfer of material between the Galilean moons, and between the moon surfaces and subsurface layers putatively including oceans. The measurement of the interactions for all the Galilean moons can be used to trace the in situ ion measurements of pickup ions back to either Europa's or Ganymede's surface from the respectively orbiting spacecraft. The IMS instrument, being developed under NASA's Astrobiology Instrument Development Program, would maximally achieve plasma measurement requirements for JEO and EJSM while moving forward our knowledge of Jupiter system composition and source processes to far higher levels than previously envisaged.

  17. The 2011 Tohoku earthquake sequences detected by IMS hydroacoustic array

    NASA Astrophysics Data System (ADS)

    Yun, S.; Lee, W.

    2011-12-01

    A Mw 9.1 thrust-fault earthquake has been occurred in the Pacific coast of Tohoku, Japan, on March 11, 2011. It is the fourth largest earthquake ever recorded since modern seismographs installed, and hundreds of strong aftershocks (M > 5) have been accompanied. We applied a cross-correlation method to the continuous data recorded in the Hawaii hydroacoustic array operated by International Monitoring System (IMS), and calculated back-azimuths of T-waves generated by the earthquake sequences. The back-azimuth values of the major events show somewhat scattered pattern, which is a different feature from that of the Great Sumatra-Andaman Earthquake. This may imply that the rupture is not likely to propagate linearly through the thrust fault line. Several aftershocks, however, clearly show gradual back-azimuthal change toward North. These differences might be caused by complex and diverse source mechanisms of the earthquakes. Combining hydroacoustic data obtained by other IMS hydroacoustic stations, if available, we could resolve a better azimuthal change regarding the earthquake sequence.

  18. Reaktive Tracer zur Bestimmung der sedimentären Aquifer-Oxidationskapazität im Labor- und Feldversuch

    NASA Astrophysics Data System (ADS)

    Dethlefsen, Frank; Bliss, Fabian; Wachter, Thorsten; Dahmke, Andreas

    Kurzfassung Mikrobiell reduzierbares Eisen(III) im Aquifer kann als Elektronenakzeptor von großer Bedeutung für Natural Attenuation (NA) von aromatischen Kohlenwasserstoffen sein und bildet den Hauptbestandteil der sedimentären Oxidationskapazität (OXC) des Aquifers. Untersuchungsgegenstand war der Vergleich traditioneller, nasschemischer Methoden mit neuentwickelten, reaktiven Tracerverfahren zur Bestimmung der sedimentären OXC. Die innovativen Tracermethoden haben gegenüber nasschemischen Extraktionsverfahren den prinzipiellen Vorteil, dass sie einen integralen Ansatz zur Bestimmung der sedimentären OXC bilden, weil geochemische und hydraulische Heterogenitäten des Aquifers berücksichtigt werden. Daher wurden am RETZINA-Standort Zeitz einerseits herkömmliche Säure-Extraktionsmethoden (bestimmter Eisen(III)-Gehalt: 0,43 +/- 0,07 mg/g Aquifermaterial) und andererseits reaktive Tracertests mit Phosphat-(Eisen(III): 1,0 mg/g) und Sulfidtracern (Eisen(III): 0,31 +/- 0,02 mg/g) in Laborversuchen sowie Bioabbauversuche mit Toluol als Kohlenstoffquelle undGeobacter metallireducensals Eisen(III)-Reduzierer (Eisen(III): 1,0 mg/g) durchgeführt. Sulfid als reaktiver Tracer wurde in Form eines 〝Push-Pull-Tests`` im Feldversuch eingesetzt (Eisen(III): 1,1 mg/g). Zudem bedeutet die Anwendung des Feld-Tracerverfahrens deutlich weniger Zeitaufwand in der Durchführung als die Anwendung traditioneller Extraktionsmethoden. Microbially reducible iron(III) is important as a terminal electron acceptor for the Natural Attenuation (NA) of aromatic hydrocarbons and forms the balance of the aquifer's sedimentary oxidation capacity (OXC). It was the aim of this investigation to compare traditional acid extraction methods to reactive tracer methods in quantifying the sedimentary OXC. The sedimentary OXC at the RETZINA test site in Zeitz was therefore determined through traditional acid extraction methods (determined Iron(III)-content: 0.43 +/- 0.07 mg/g aquifer material) and

  19. IMS Version 3 1971-72 Tryout: Initial Report on COMSYS 1 and 2 Computer Operations.

    ERIC Educational Resources Information Center

    Flournoy, Nancy

    Instructional Management System (IMS) information cycles from participating schools to the Southwest Regional Laboratory (SWRL) for processing, returning again to the school in the form of summarized reports of pupil data. One segment of this cycle is managed by the IMS pupil data base processing program. The program generates reports from…

  20. User Training for the 1971-72 Tryout of IMS, Version 3.

    ERIC Educational Resources Information Center

    Gibbs, Gordon L.

    Proposed training procedures and materials, and participants' questions on the use of the Southwest Regional Laboratory's (SWRL) student monitoring system data base in the Instructional Management System (IMS) are described. The training sessions were undertaken because IMS Version 3 requires classroom teachers to use special materials and…

  1. Procedures for COMSYS 3 for the 1971-72 IMS Tryout.

    ERIC Educational Resources Information Center

    Gibbs, Gordon L.

    During the 1971-72 pilot test of the Southwest Regional Laboratory's (SWRL) Instructional Management System (IMS), three alternative procedures were used to gather data within the classroom, transmit those data to SWRL for processing, and send IMS output to the appropriate recipients in the schools. ComSys 3--one of the three…

  2. The Conceptual Structure of IMS Learning Design Does Not Impede Its Use for Authoring

    ERIC Educational Resources Information Center

    Derntl, M.; Neumann, S.; Griffiths, D.; Oberhuemer, P.

    2012-01-01

    IMS Learning Design (LD) is the only available interoperability specification in the area of technology enhanced learning that allows the definition and orchestration of complex activity flows and resource environments in a multirole setting. IMS LD has been available since 2003, and yet it has not been widely adopted either by practitioners or by…

  3. Crystal Structure of the 25 kDa Subunit of Human Cleavage Factor I{m}

    SciTech Connect

    Coseno,M.; Martin, G.; Berger, C.; Gilmartin, G.; Keller, W.; Doublie, S.

    2008-01-01

    Cleavage factor Im is an essential component of the pre-messenger RNA 3'-end processing machinery in higher eukaryotes, participating in both the polyadenylation and cleavage steps. Cleavage factor Im is an oligomer composed of a small 25 kDa subunit (CF Im25) and a variable larger subunit of either 59, 68 or 72 kDa. The small subunit also interacts with RNA, poly(A) polymerase, and the nuclear poly(A)-binding protein. These protein-protein interactions are thought to be facilitated by the Nudix domain of CF Im25, a hydrolase motif with a characteristic {alpha}/{beta}/{alpha} fold and a conserved catalytic sequence or Nudix box. We present here the crystal structures of human CF Im25 in its free and diadenosine tetraphosphate (Ap4A) bound forms at 1.85 and 1.80 Angstroms, respectively. CF Im25 crystallizes as a dimer and presents the classical Nudix fold. Results from crystallographic and biochemical experiments suggest that CF Im25 makes use of its Nudix fold to bind but not hydrolyze ATP and Ap4A. The complex and apo protein structures provide insight into the active oligomeric state of CF Im and suggest a possible role of nucleotide binding in either the polyadenylation and/or cleavage steps of pre-messenger RNA 3'-end processing.

  4. Computer-Aided Teaching Using MATLAB/Simulink for Enhancing an IM Course With Laboratory Tests

    ERIC Educational Resources Information Center

    Bentounsi, A.; Djeghloud, H.; Benalla, H.; Birem, T.; Amiar, H.

    2011-01-01

    This paper describes an automatic procedure using MATLAB software to plot the circle diagram for two induction motors (IMs), with wound and squirrel-cage rotors, from no-load and blocked-rotor tests. The advantage of this approach is that it avoids the need for a direct load test in predetermining the IM characteristics under reduced power.…

  5. Peste des Petits Ruminants Virus.

    PubMed

    Baron, M D; Diallo, A; Lancelot, R; Libeau, G

    2016-01-01

    Peste des petits ruminants virus (PPRV) causes a severe contagious disease of sheep and goats and has spread extensively through the developing world. Because of its disproportionately large impact on the livelihoods of low-income livestock keepers, and the availability of effective vaccines and good diagnostics, the virus is being targeted for global control and eventual eradication. In this review we examine the origin of the virus and its current distribution, and the factors that have led international organizations to conclude that it is eradicable. We also review recent progress in the molecular and cellular biology of the virus and consider areas where further research is required to support the efforts being made by national, regional, and international bodies to tackle this growing threat. PMID:27112279

  6. The Applicability of Incoherent Array Processing to IMS Seismic Arrays

    NASA Astrophysics Data System (ADS)

    Gibbons, Steven J.

    2014-03-01

    The seismic arrays of the International Monitoring System (IMS) for the Comprehensive Nuclear-Test-Ban Treaty (CTBT) are highly diverse in size and configuration, with apertures ranging from under 1 km to over 60 km. Large and medium aperture arrays with large inter-site spacings complicate the detection and estimation of high-frequency phases lacking coherence between sensors. Pipeline detection algorithms often miss such phases, since they only consider frequencies low enough to allow coherent array processing, and phases that are detected are often attributed qualitatively incorrect backazimuth and slowness estimates. This can result in missed events, due to either a lack of contributing phases or by corruption of event hypotheses by spurious detections. It has been demonstrated previously that continuous spectral estimation can both detect and estimate phases on the largest aperture arrays, with arrivals identified as local maxima on beams of transformed spectrograms. The estimation procedure in effect measures group velocity rather than phase velocity, as is the case for classical f-k analysis, and the ability to estimate slowness vectors requires sufficiently large inter-sensor distances to resolve time-delays between pulses with a period of the order 4-5 s. Spectrogram beampacking works well on five IMS arrays with apertures over 20 km (NOA, AKASG, YKA, WRA, and KURK) without additional post-processing. Seven arrays with 10-20 km aperture (MJAR, ESDC, ILAR, KSRS, CMAR, ASAR, and EKA) can provide robust parameter estimates subject to a smoothing of the resulting slowness grids, most effectively achieved by convolving the measured slowness grids with the array response function for a 4 or 5 s period signal. Even for medium aperture arrays which can provide high-quality coherent slowness estimates, a complementary spectrogram beampacking procedure could act as a quality control by providing non-aliased estimates when the coherent slowness grids display

  7. Ultrawideband SAR processing with the Range Migration Algorithm and the ImSyn processor

    NASA Astrophysics Data System (ADS)

    Phillips, Louis C.; Eichel, Laurence A.; Evanko, Stephen M.

    1996-11-01

    The ImSynTM Processor is an optoelectronic signal processor developed by Essex Corporation to accelerate coherent imaging processes. This paper focuses on the application of the ImSyn Processor to SAR imaging where severe range differential curvature is present. This occurs in SAR systems imaging large scenes with fine resolution, foliage penetrating (FOPEN) radar and ground penetrating radar. Application of the range migration algorithm removes the differential range curvature but results in a non- uniform or warped frequency space. The ImSyn processor operates directly on the frequency data permitting a discrete Fourier transform in warped frequency space without data interpolation. Both the range migration algorithm and the standard polar formatting algorithm benefit from the increased speed and resolution available from the ImSyn processor. A discussion of the ImSyn processor, the range migration algorithm and an example of a FOPEN image processed on our prototype system are presented.

  8. [((Cl)Im(Dipp))P=P(Dipp)][GaCl4]: a polarized, cationic diphosphene.

    PubMed

    Schwedtmann, Kai; Holthausen, Michael H; Sala, Chris H; Hennersdorf, Felix; Fröhlich, Roland; Weigand, Jan J

    2016-01-25

    The reaction of the neutral diphosphanide [((Cl)Im(Dipp))P-P(Cl)(Dipp)] (6) ((Cl)Im(Dipp) = 4,5-dichloro-1,3-bis(Dipp)-imidazol-2-yl; Dipp = 2,6-di-iso-propylphenyl) with methyl triflate (MeOTf) leads to the formation of cationic diphosphane [((Cl)Im(Dipp))(Me)P-P(Cl)(Dipp)](+) (8+) in a stereoselective methylation. In contrast, reacting with the Lewis acid GaCl3 yields cationic diphosphene [((Cl)Im(Dipp))P=P(Dipp)](+) (7+), which is explained by a low P-Cl bond dissociation energy. The significantly polarized P=P double bond in 7+ allows for its utilization as an acceptor for nucleophiles - the reaction with Cl(-) regenerates diphosphanide and the reaction with PMe3 gives cation [((Cl)Im(Dipp))P-P(PMe3)(Dipp)] (9+). In depth DFT investigation provides detailed insights into the bonding situation of the reported compounds. PMID:26627185

  9. The enhancement of existing DES Maplet interface

    NASA Astrophysics Data System (ADS)

    Abdullah, Nur Lina; Mutalip, Rasidah Abdull; Abdullah, Kamilah

    2014-07-01

    This study pertains to the process of Data Encryption Standard, DES. DES consists of encryption and decryption processes linked with mathematical elements such as algebra and number theory. Preliminary, studies revealed that most of mathematics students face a problem in understanding the complicated process of DES. In modern learning methods, learning environment becomes more interesting with the use of computer and a variety of mathematical software packages. Several mathematical softwares such as Maple, Mathematica, Mathlab and Sage were developed in order to fulfill the specific calculation requirements. Correspondingly, motivated from that, this study incorporated with Maple to enhance the existing DES Maplet interface to be more interactive and user-friendly compared to the original version.

  10. Copernic: la piste des influences arabes

    NASA Astrophysics Data System (ADS)

    Khalatbari, A.; Bonnet-Bidaud, J. M.

    2004-10-01

    Copernic a-t-il connu le travail des astronomes du Moyen-Orient ? S'en est-il inspiré pour élaborer sa théorie de l'héliocentrisme ? C'est l'hypothèse avancée par certains historiens des sciences pour comprendre le génie de celui qui, le premier, a placé le Soleil au centre du monde. Enquête.

  11. Snapshot hyperspectral retinal camera with the Image Mapping Spectrometer (IMS)

    PubMed Central

    Gao, Liang; Smith, R. Theodore; Tkaczyk, Tomasz S.

    2011-01-01

    We present a snapshot hyperspectral retinal camera with the Image Mapping Spectrometer (IMS) for eye imaging applications. The resulting system is capable of simultaneously acquiring 48 spectral channel images in the range 470 nm–650 nm with frame rate at 5.2 fps. The spatial sampling of each measured spectral scene is 350 × 350 pixels. The advantages of this snapshot device are elimination of the eye motion artifacts and pixel misregistration problems in traditional scanning-based hyperspectral retinal cameras, and real-time imaging of oxygen saturation dynamics with sub-second temporal resolution. The spectral imaging performance is demonstrated in a human retinal imaging experiment in vivo. The absorption spectral signatures of oxy-hemoglobin and macular pigments were successfully acquired by using this device. PMID:22254167

  12. Sorrell v. IMS Health: issues and opportunities for informaticians

    PubMed Central

    Petersen, Carolyn; DeMuro, Paul; Goodman, Kenneth W; Kaplan, Bonnie

    2013-01-01

    In 2011, the US Supreme Court decided Sorrell v. IMS Health, Inc., a case that addressed the mining of large aggregated databases and the sale of prescriber data for marketing prescription drugs. The court struck down a Vermont law that required data mining companies to obtain permission from individual providers before selling prescription records that included identifiable physician prescription information to pharmaceutical companies for drug marketing. The decision was based on constitutional free speech protections rather than data sharing considerations. Sorrell illustrates challenges at the intersection of biomedical informatics, public health, constitutional liberties, and ethics. As states, courts, regulatory agencies, and federal bodies respond to Sorrell, informaticians’ expertise can contribute to more informed, ethical, and appropriate policies. PMID:23104048

  13. Wie viel Schwermetall ist im Trinkwasser?: Optische Spektroskopie

    NASA Astrophysics Data System (ADS)

    Niehus, Christina; Trull, Thomas; Möllmann, Klaus-Peter; Vollmer, Michael

    2002-11-01

    Die moderne optische Spektroskopie kann geringste Substanzmengen nachweisen. Für schnelle Routinemessungen reichen konventionelle Zweistrahl-Spektralphotometer. Eine wesentlich höhere Nachweisempfindlichkeit im ppm- oder sogar ppb-Bereich ermöglichen das Atomabsorptions-Spektrometer (AAS) und das Fourier-Transformations-Infrarot-Spektrometer (FTIR). Ein AAS atomisiert die Probe vollständig und weist dann einzelne Elemente nach. Deshalb ist es zum Beispiel für die Schwermetall-Analyse geeignet. Bei der Analyse von Molekülen dominieren heute FTIR-Geräte. Ihr Herzstück ist meist ein Michelson-Interferometer. Zusammen mit schnellen Fourier-Algorithmen erlaubt es, sehr schnell breite Spektren aufzunehmen. Stationäre und mobile FTIR-Geräte können vielfältig eingesetzt werden.

  14. Absolute properties of the eclipsing binary star IM Persei

    SciTech Connect

    Lacy, Claud H. Sandberg; Torres, Guillermo; Fekel, Francis C.; Muterspaugh, Matthew W.; Southworth, John E-mail: gtorres@cfa.harvard.edu E-mail: matthew1@coe.tsuniv.edu

    2015-01-01

    IM Per is a detached A7 eccentric eclipsing binary star. We have obtained extensive measurements of the light curve (28,225 differential magnitude observations) and radial velocity curve (81 spectroscopic observations) which allow us to fit orbits and determine the absolute properties of the components very accurately: masses of 1.7831 ± 0.0094 and 1.7741 ± 0.0097 solar masses, and radii of 2.409 ± 0.018 and 2.366 ± 0.017 solar radii. The orbital period is 2.25422694(15) days and the eccentricity is 0.0473(26). A faint third component was detected in the analysis of the light curves, and also directly observed in the spectra. The observed rate of apsidal motion is consistent with theory (U = 151.4 ± 8.4 year). We determine a distance to the system of 566 ± 46 pc.

  15. Sorrell v. IMS Health: issues and opportunities for informaticians.

    PubMed

    Petersen, Carolyn; Demuro, Paul; Goodman, Kenneth W; Kaplan, Bonnie

    2013-01-01

    In 2011, the US Supreme Court decided Sorrell v. IMS Health, Inc., a case that addressed the mining of large aggregated databases and the sale of prescriber data for marketing prescription drugs. The court struck down a Vermont law that required data mining companies to obtain permission from individual providers before selling prescription records that included identifiable physician prescription information to pharmaceutical companies for drug marketing. The decision was based on constitutional free speech protections rather than data sharing considerations. Sorrell illustrates challenges at the intersection of biomedical informatics, public health, constitutional liberties, and ethics. As states, courts, regulatory agencies, and federal bodies respond to Sorrell, informaticians' expertise can contribute to more informed, ethical, and appropriate policies. PMID:23104048

  16. Software enhancements to the IVSEM model of the CTBTO IMS.

    SciTech Connect

    Damico, Joseph P.

    2011-03-01

    Sandia National Laboratories (SNL) developed the Integrated Verification System Evaluation Model (IVSEM) to estimate the performance of the International Monitoring System (IMS) operated by the Comprehensive Nuclear Test Ban Treaty Organization (CTBTO). IVSEM was developed in several phases between 1995 and 2000. The model was developed in FORTRAN with an IDL-based user interface and was compiled for Windows and UNIX operating systems. Continuing interest in this analysis capability, coupled with numerous advances in desktop computer hardware and software since IVSEM was written, enabled significant improvements to IVSEM run-time performance and data analysis capabilities. These improvements were implemented externally without modifying the FORTRAN executables, which had been previously verified. This paper describes the parallelization approach developed to significantly reduce IVSEM run-times and the new test setup and analysis tools developed to facilitate better IVSEM operation.

  17. Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation.

    PubMed

    Hardy, Jessica G; Norbury, Chris J

    2016-08-15

    Most mammalian protein coding genes are subject to alternative cleavage and polyadenylation (APA), which can generate distinct mRNA 3'UTRs with differing regulatory potential. Although this process has been intensely studied in recent years, it remains unclear how and to what extent cleavage site selection is regulated under different physiological conditions. The cleavage factor Im (CFIm) complex is a core component of the mammalian cleavage machinery, and the observation that its depletion causes transcriptome-wide changes in cleavage site use makes it a key candidate regulator of APA. This review aims to summarize current knowledge of the CFIm complex, and explores the evidence surrounding its potential contribution to regulation of APA. PMID:27528751

  18. Diffusion des Metaux et Evolution Stellaire

    NASA Astrophysics Data System (ADS)

    Turcotte, Sylvain

    Nous presentons dans cette these des modeles d'evolution stellaire incorporant la diffusion microscopique de maniere consistante. Pour la premiere fois, on a calcule l'evolution d'etoiles en tenant compte en detail de l'impact des variations d'abondances sur leur structure. Nous utilisons des spectres monochromatiques pour chacun des elements les plus abondants dans un melange solaire pour recalculer l'opacite pour les abondances et les conditions locales dans l'interieur d'une etoile au cours de son evolution. Nos modeles montrent que la diffusion atomique des metaux a un effet important sur les opacites dan les etoiles de plus de 1.3Msolar ou l'abondance du fer et des autres elements du pic du fer varient substantiellement. Ces etoiles, sans rotation ou champ magnetique, sont proches des etoiles de type Fm-Am dans lesquelles on observe une legere surabondance d'elements du pic du fer en plus d'une sous-abondance de calcium, sous-abondance que l'on obtient egalement. Nous obtenons cependant des surabondances depassant un facteur 10 pour les etoiles de plus de 1.4Msolar ce qui suggere qu'il existe un ou plusieurs mecanismes limitant la diffusion microscopique. La surabondance du fer en surface cause une augmentation, qui peut atteindre un facteur sept, de l'opacite a la limite de la zone convective. Ceci cause un accroissement de la temperature effective et de la masse de la zone convective comparativement aux modeles n'incluant que la diffusion de l'helium. Il s'agit la du principal effet de la diffusion sur la structure interne de ces etoiles. La diffusions n'a pas d'influence sur l'evolution de coeur stellaire dans les etoiles significativement plus massives quie le Soleil. Nous avons verife que l'utilisation de modeles consistants avec diffusion n'apporte pas d'amelioration sensible aux modeles solaires. Les forces radiatives calculees a partir des spectres d'OPAL pour les elements du pic du fer representent une fraction importante de la gravite. On obtient des

  19. IMS/Satellite Situation Center report. Daily summary for IMS high-altitude satellites, days 182-365 1977

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The orbital positions of a number of high-altitude satellites, capable of making magnetospheric measurements in the second half of 1977, are described. The following satellites are considered: Vela 5A, Vela 5B, Vela 6A, Vela 6B, Solrad 11A, Solrad 11B, Hawkeye 1, Prognoz 5, Explorer 47, Explorer 50, and ISEE-A/-B. The orbit elements used for generating the satellite ephemeris are shown. Complete presentations of the positions of these satellites for the second half of 1977 are given, as well as the IMS/SSC special periods. Detailed plots illustrating these periods are provided. Time-ordered tables of magnetopause crossings, bow shock crossings, neutral sheet passes, midlatitude magnetotail passes, high-latitude magnetotail passes, and Hawkeye 1 northern cusp passes are presented. Bar charts covering the second half of 1977 are given which identify thirteen special periods (Nos. 10-22) based upon certain conjunctions of the high-altitude satellites.

  20. Different enzyme requirements for the synthesis of biodiesel: Novozym 435 and Lipozyme TL IM.

    PubMed

    Hernández-Martín, Estela; Otero, Cristina

    2008-01-01

    Enzymatic syntheses of biodiesel via alcoholysis of different vegetable oils (sunflower, borage, olive and soybean) have been studied. Loss of lipase activity induced by the nucleophile is greater with methanol than with ethanol, and is greater for Lipozyme TL IM than for Novozym 435. The optimum volume of ethanol depends on the loading of solid biocatalyst and is higher for preparations of Novozym 435 than for Lipozyme TL IM. Maximum rates were obtained with Lipozyme TL IM, for a molar ratio of alcohol to FA residues of 0.33. By contrast, Novozym 435 requires at least a 2:1 ratio. Alcoholysis of the vegetable oils is faster with Lipozyme TL IM than with Novozym 435. Use of a high loading of Novozym 435 (50% w/w) and a large molar excess of ethanol are required to obtain an initial rate similar to that obtained with Lipozyme TL IM at a lower enzyme loading (10% w/w) and an equimolar ratio of ethanol and FA residues. Novozym 435 produces quantitative conversions in only 7h at 25 degrees C, but complete conversions are not obtained with Lipozyme TL IM. Three stage stepwise addition of ethanol yields 84% conversion to ethyl esters for Lipozyme TL IM. Hence use of Novozym 435 is preferred. After nine cycles in a batch reactor Novozym 435 retained 85% of its initial activity. PMID:17321130

  1. Platoon Interactions and Real-World Traffic Simulation and Validation Based on the LWR-IM.

    PubMed

    Ng, Kok Mun; Reaz, Mamun Bin Ibne

    2016-01-01

    Platoon based traffic flow models form the underlying theoretical framework in traffic simulation tools. They are essentially important in facilitating efficient performance calculation and evaluation in urban traffic networks. For this purpose, a new platoon-based macroscopic model called the LWR-IM has been developed in [1]. Preliminary analytical validation conducted previously has proven the feasibility of the model. In this paper, the LWR-IM is further enhanced with algorithms that describe platoon interactions in urban arterials. The LWR-IM and the proposed platoon interaction algorithms are implemented in the real-world class I and class II urban arterials. Another purpose of the work is to perform quantitative validation to investigate the validity and ability of the LWR-IM and its underlying algorithms to describe platoon interactions and simulate performance indices that closely resemble the real traffic situations. The quantitative validation of the LWR-IM is achieved by performing a two-sampled t-test on queues simulated by the LWR-IM and real queues observed at these real-world locations. The results reveal insignificant differences of simulated queues with real queues where the p-values produced concluded that the null hypothesis cannot be rejected. Thus, the quantitative validation further proved the validity of the LWR-IM and the embedded platoon interactions algorithm for the intended purpose. PMID:26731745

  2. Applied Doppler Imaging: Can The Magnetic Activity Of IM Pegasi Affect The Gravity Probe B Mission?

    NASA Astrophysics Data System (ADS)

    Marsden, S. C.; Berdyugina, S. V.

    2006-08-01

    IM Pegasi is a single-lined spectroscopic RS CVn binary, with the primary being a rapidly-rotating (vsini = 27 km/s) early-K giant. Magnetic activity of the primary is evident as dark spot features covering 15% or more of the stellar surface. Since the system is bright in both optical and radio bands, IM Pegasi was chosen as a guide star for the Gravity Probe B (GP-B) satellite mission. The mission is designed to verify two predictions of Einstein's theory of general relativity, the geodetic effect and "frame-dragging", based on measurements of mean gyroscope drift with respect to the optical centroid of IM Pegasi. The requested standard error of 0.5 milliarcseconds/year implies that even small contributions to the shift of the optical centroid of IM Pegasi due to surface magnetic activity must be determined. In support of the GP-B mission we are undertaking an intensive Doppler imaging survey of the primary component of IM Pegasi to determine the effect of spot features on the optical centroid of IM Pegasi. We present an overview of our role in GP-B and report initial results from this support project, including the first magnetic maps of the IM Pegasi primary, created using Least-Squares Deconvolution and Zeeman Doppler Imaging.

  3. Platoon Interactions and Real-World Traffic Simulation and Validation Based on the LWR-IM

    PubMed Central

    Ng, Kok Mun; Reaz, Mamun Bin Ibne

    2016-01-01

    Platoon based traffic flow models form the underlying theoretical framework in traffic simulation tools. They are essentially important in facilitating efficient performance calculation and evaluation in urban traffic networks. For this purpose, a new platoon-based macroscopic model called the LWR-IM has been developed in [1]. Preliminary analytical validation conducted previously has proven the feasibility of the model. In this paper, the LWR-IM is further enhanced with algorithms that describe platoon interactions in urban arterials. The LWR-IM and the proposed platoon interaction algorithms are implemented in the real-world class I and class II urban arterials. Another purpose of the work is to perform quantitative validation to investigate the validity and ability of the LWR-IM and its underlying algorithms to describe platoon interactions and simulate performance indices that closely resemble the real traffic situations. The quantitative validation of the LWR-IM is achieved by performing a two-sampled t-test on queues simulated by the LWR-IM and real queues observed at these real-world locations. The results reveal insignificant differences of simulated queues with real queues where the p-values produced concluded that the null hypothesis cannot be rejected. Thus, the quantitative validation further proved the validity of the LWR-IM and the embedded platoon interactions algorithm for the intended purpose. PMID:26731745

  4. CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes

    SciTech Connect

    Reisman, Scott A.; Buckley, David B.; Tanaka, Yuji; Klaassen, Curtis D.

    2009-04-01

    CDDO-Im is a synthetic triterpenoid recently shown to induce cytoprotective genes through the Nrf2-Keap1 pathway, an important mechanism for the induction of cytoprotective genes in response to oxidative stress. Upon oxidative or electrophilic insult, the transcription factor Nrf2 translocates to the nucleus, heterodimerizes with small Maf proteins, and binds to antioxidant response elements (AREs) in the upstream promoter regions of various cytoprotective genes. To further elucidate the hepatoprotective effects of CDDO-Im, wild-type and Nrf2-null mice were pretreated with CDDO-Im (1 mg/kg, i.p.) or vehicle (DMSO), and then administered acetaminophen (500 mg/kg, i.p.). Pretreatment of wild-type mice with CDDO-Im reduced liver injury caused by acetaminophen. In contrast, hepatoprotection by CDDO-Im was not observed in Nrf2-null mice. CDDO-Im increased Nrf2 protein expression and Nrf2-ARE binding in wild-type, but not Nrf2-null mice. Furthermore, CDDO-Im increased the mRNA expression of the Nrf2 target genes NAD(P)H: quinone oxidoreductase-1 (Nqo1); glutamate-cysteine ligase, catalytic subunit (Gclc); and heme-oxygenase-1 (Ho-1), in both a dose- and time-dependent manner. Conversely, CDDO-Im did not induce Nqo1, Gclc, and Ho-1 mRNA expression in Nrf2-null mice. Collectively, the present study shows that CDDO-Im pretreatment induces Nrf2-dependent cytoprotective genes and protects the liver from acetaminophen-induced hepatic injury.

  5. Monitoring the Earth's Atmosphere with the Global IMS Infrasound Network

    NASA Astrophysics Data System (ADS)

    Brachet, Nicolas; Brown, David; Mialle, Pierrick; Le Bras, Ronan; Coyne, John; Given, Jeffrey

    2010-05-01

    , they represent valuable data for other civil applications like monitoring of natural hazards (volcanic activity, storm tracking) and climate change. Non-noise detections are used in network processing at the IDC along with seismic and hydroacoustic technologies. The arrival phases detected on the three waveform technologies may be combined and used for locating events in an automatically generated bulletin of events. This automatic event bulletin is routinely reviewed by analysts during the interactive review process. However, the fusion of infrasound data with the other waveform technologies has only recently (in early 2010) become part of the IDC operational system, after a software development and testing period that began in 2004. The build-up of the IMS infrasound network, the recent developments of the IDC infrasound software, and the progress accomplished during the last decade in the domain of real-time atmospheric modelling have allowed better understanding of infrasound signals and identification of a growing data set of ground-truth sources. These infragenic sources originate from natural or man-made sources. Some of the detected signals are emitted by local or regional phenomena recorded by a single IMS infrasound station: man-made cultural activity, wind farms, aircraft, artillery exercises, ocean surf, thunderstorms, rumbling volcanoes, iceberg calving, aurora, avalanches. Other signals may be recorded by several IMS infrasound stations at larger distances: ocean swell, sonic booms, and mountain associated waves. Only a small fraction of events meet the event definition criteria considering the Treaty verification mission of the Organization. Candidate event types for the IDC Reviewed Event Bulletin include atmospheric or surface explosions, meteor explosions, rocket launches, signals from large earthquakes and explosive volcanic eruptions.

  6. Large meteoroid detection using the global IMS infrasound system

    SciTech Connect

    ReVelle, D. O.

    2002-01-01

    Numerous signals will be routinely detected using the 60 array, global IMS (International Monitoring System) infrasound network. Infrasonic signals are sub-audible quasi longitudinal, atmospheric waves in the frequency band from about 10 Hz to -5 minutes in period (limited by human acoustic audibility in the high frequency limit and by the wave-guide acoustic cut-off frequency and the Brunt Vaisalla frequency in the low frequency limit) These small amplitude waves are a natural subset of the well-known atmospheric acoustic-gravity wave regime which has been identified from the linearized equations of geophysical fluid mechanics in the flat earth approximation, neglecting the earth's rotation, etc. For the IMS network the instrumental pressure sensor response was chosen to range from -4 to 0.02 Hz. These are ground-based arrays of typically 4 to 9 sensors with separations of about 1-2 km between the array elements. Examples of naturally occurring impulsive sources of infrasound include volcanic eruptions, earthquakes, bolides (large meteor-fireballs entering the atmospheric at very high speeds up to -300 times faster than ground-level sound waves), microbaroms (the 'voice of the sea' due to the interaction of atmospheric storms and surface ocean waves) and the supersonic motion of the auroral electrojet at about 100 km altitude (auroral infrasonic waves), etc. In this paper we will briefly summarize our current state of knowledge of infrasound signals from bolides. This summary will include the generation of the signals at the complex, quasi-cylindrical line source, to the refraction and diffraction of the propagating waves by the middle atmospheric and tropospheric temperature and wind systems and finally, the detection of the signals and their interpretation by inferring the source properties, Le., source altitude, blast radius (see below) and the source energy, etc. In addition, we will use infrasound from energetic bolides to estimate the expected steady state

  7. 33 CFR 117.439 - Des Allemands Bayou.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Des Allemands Bayou. 117.439... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Louisiana § 117.439 Des Allemands Bayou. (a) The draw of the S631 bridge, mile 13.9 at Des Allemands, shall open on signal if at least four hours notice...

  8. 33 CFR 117.439 - Des Allemands Bayou.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Des Allemands Bayou. 117.439... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Louisiana § 117.439 Des Allemands Bayou. (a) The draw of the S631 bridge, mile 13.9 at Des Allemands, shall open on signal if at least four hours notice...

  9. 33 CFR 117.439 - Des Allemands Bayou.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Des Allemands Bayou. 117.439... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Louisiana § 117.439 Des Allemands Bayou. (a) The draw of the S631 bridge, mile 13.9 at Des Allemands, shall open on signal if at least four hours notice...

  10. IM-133N - A Useful Herbal Combination for Eradicating Disease-triggering Pathogens in Mice via Immunotherapeutic Mechanisms

    PubMed Central

    Firashathulla, Syed; Inamdar, Mohammed Naseeruddin; Rafiq, Mohamed; Viswanatha, Gollapalle Lakshminarayanashastry; Sharath Kumar, Lakkavalli Mohan; Babu, Uddagiri Venkanna; Ramakrishnan, Shyam; Paramesh, Rangesh

    2016-01-01

    Objectives: The present study was undertaken to evaluate the immunomodulatory (IM) activity of IM-133N, a herbal combination in various immunotherapeutic experimental models. Methods: The IM activity of IM-133N was evaluated against three experimental models namely, effect of IM- 133N against Escherichia coli (E. coli)-induced abdominal sepsis in mice, and carbon clearance test was performed in Wistar albino rats to evaluated the phagocytic potential of IM-133N, in addition IM-133N was evaluated for its immunoglobulin enhancing potential in rats, where the immunoglobulin levels were measured by zinc sulphate turbity (ZST) test. Further, IM-133N was subjected for detailed liquid chromatography-mass spectrometry (LC-MS)/MS analysis to identify the probable active constituents present in it. Results: The findings of the present study has demonstrated very promising IM property of IM-133N in all the experimental models. Briefly, pretreatment with IM-133N at 125, 250, 500 and 1,000 mg/kg, p.o. doses had protected the mice against E. coli-induced abdominal sepsis and mortality, further the effect of IM- 133N was found to be significant and dose-dependent. In support of this, in another study administration of IM-133N showed a significant and dose-dependent increase in serum immunoglobulin levels, estimated by ZST test. In line with the above findings, in the carbon clearance test the low doses (125 and 250 mg/ kg, p.o.) of IM-133N increased the rate of carbon clearance, whereas the higher doses (500 and 1,000 mg/kg, p.o.) did not sustain the response, and saturation effect was considered as one of the possible reason for futility of higher doses for IM-133N. In addition, A detailed LC-MS/MS analysis of IM-133N showed 17 bioactive phytochemical constituents: namely, apigenin, chaulmoogric acid, mesquitol, quercetin, symphoxanthone, salireposide, β-sitosterol, nonaeicosanol, β-amyrin, betulic acid, oleanolic acid, symplososide, symponoside, symploveroside, symplocomoside

  11. A structural comparison of the colicin immunity proteins Im7 and Im9 gives new insights into the molecular determinants of immunity-protein specificity.

    PubMed Central

    Dennis, C A; Videler, H; Pauptit, R A; Wallis, R; James, R; Moore, G R; Kleanthous, C

    1998-01-01

    We report the first detailed comparison of two immunity proteins which, in conjunction with recent protein engineering data, begins to explain how these structurally similar proteins are able to bind and inhibit the endonuclease domain of colicin E9 (E9 DNase) with affinities that differ by 12 orders of magnitude. In the present work, we have determined the X-ray structure of the Escherichia coli colicin E7 immunity protein Im7 to 2.0 A resolution by molecular replacement, using as a trial model the recently determined NMR solution structure of Im9. Whereas the two proteins adopt similar four-helix structures, subtle structural differences, in particular involving a conserved tyrosine residue critical for E9 DNase binding, and the identity of key residues in the specificity helix, lie at the heart of their markedly different ability to bind the E9 DNase. Two other crystal structures were reported recently for Im7; in one, Im7 was a monomer and was very similar to the structure reported here, whereas in the other it was a dimer to which functional significance was assigned. Since this previous work suggested that Im7 could exist either as a monomer or a dimer, we used analytical ultracentrifugation to investigate this question further. Under a variety of solution conditions, we found that Im7 only ever exists in solution as a monomer, even up to protein concentrations of 15 mg/ml, casting doubt on the functional significance of the crystallographically observed dimer. This work provides a structural framework with which we can understand immunity-protein specificity, and in addition we believe it to be the first successfully refined crystal structure solved by molecular replacement using an NMR trial model with less than 100% sequence identity. PMID:9639578

  12. Ccd Photometry of Neglected Eclipsing Binaries Kz Dra, Lr Cam and Im Vul

    NASA Astrophysics Data System (ADS)

    Pejcha, Ondřej; Motl, David; Zejda, Miloslav; Koss, Karel; Kudrnáčová, Jitka; Hájek, Petr; Šmelcer, Ladislav; Dubovský, Pavol A.; Šafářová, Eva; Wolf, Marek

    2005-04-01

    We present ephemerides and solutions of one Algol-type (KZ Dra) and two overcontact systems (LR Cam and IM Vul) based on V(RI)C CCD observations obtained in the project Prosper (network of amateur observers).

  13. A structural equation model relating physical function, pain, impaired mobility (IM), and falls in older adults.

    PubMed

    Dai, Boyi; Ware, William B; Giuliani, Carol A

    2012-01-01

    The current study used a structural equation model to investigate the interrelationships among physical function, pain, IM, and falls in 511 American older adults. The model included 11 measurement variables (tandem stance, single leg stance, 360° turn, chair stand, arm curl, sit and reach, back scratch, normative score of 6-min walk or 2-min step, timed up and go, pain, and fall) and four latent variables (balance, strength, flexibility, and IM). The final model with the combined sample demonstrated good fit with the participant data (χ(2)(31)=30.0, N=499, p=0.52; Goodness of Fit Index (GFI)=0.99). Balance had a significant and the largest effect on IM (standardized regression weights=-1.05, p<0.001). Strength, endurance, flexibility, and pain had small effects on IM (standardized regression weights<0.2). The findings suggest that balance and mobility testing should be a priority in fall screening and prevention programs. PMID:22766209

  14. CRYPTOSPORIDIUM OOCYST RECOVERY IN WATER BY EPA METHOD 1623: EVALUATION OF A MODIFIED IMS DISSOCIATION

    EPA Science Inventory

    EPA Methods 1622 and 1623 are the benchmarks for detection of Cryptosporidium spp. oocysts in water. These methods consist of filtration, elution, purification by immunomagnetic separation (IMS), and microscopic analysis after staining with a fluorescein isothiocyanate conjugate...

  15. The IMS Satellite Situation Center. [International Magnetospheric Study

    NASA Technical Reports Server (NTRS)

    Sugiura, M.; Vette, J. I.

    1977-01-01

    Following a brief historical review of the SSC (Satellite Situation Center), created by the U.S. for the IMS (International Magnetospheric Study), its main functions are discussed. The services of the SSC include the accurate orbit determination of the satellites, 12-18 months in advance and the coordination of simultaneous observations by a multispacecraft system, which are essential for the optimization of the scientific gains from experiments conducted with limited resources. For 1976 SSC generated plots of the satellites Vela 5B, Vela 6A, Vela 6B, Hawkeye 1, Imp H (7), Imp J (8) by computing certain projections of the solar ecliptic, solar magnetospheric, and solar magnetic coordinate systems. The SSC system was automated by the addition of a computer system capable of interactive graphics. The SSC can also provide the ground-based campaigns with a graphical or tabular information about the position low-altitude satellites in any coordinate system. The possible participation of the SSC in future Electrodynamics Explorer mission, Space Shuttle programs is also being explored.

  16. IMGT, the international ImMunoGeneTics database.

    PubMed

    Lefranc, Marie-Paule

    2003-01-01

    The international ImMunoGeneTics database (IMGT) (http://imgt.cines.fr), is a high quality integrated information system specializing in Immunoglobulins (IG), T cell Receptors (TR) and Major Histocompatibility Complex (MHC) of human and other vertebrates, created in 1989, by the Laboratoire d'ImmunoGénétique Moléculaire (LIGM), at the Université Montpellier II, CNRS, Montpellier, France. IMGT provides a common access to standardized data which include nucleotide and protein sequences, oligonucleotide primers, gene maps, genetic polymorphisms, specificities, 2D and 3D structures. IMGT includes three sequence databases (IMGT/LIGM-DB, IMGT/MHC-DB, IMGT/PRIMER-DB), one genome database (IMGT/GENE-DB) with different interfaces (IMGT/GeneSearch, IMGT/GeneView, IMGT/LocusView), one 3D structure database (IMGT/3Dstructure-DB), Web resources comprising 8000 HTML pages ('IMGT Marie-Paule page') and interactive tools for sequence analysis (IMGT/V-QUEST, IMGT/JunctionAnalysis, IMGT/Allele-Align, IMGT/PhyloGene). IMGT data are expertly annotated according to the rules of the IMGT Scientific chart, based on IMGT-ONTOLOGY. IMGT tools are particularly useful for the analysis of the IG and TR repertoires in physiological normal and pathological situations. IMGT has important applications in medical research (autoimmune diseases, AIDS, leukemias, lymphomas, myelomas), biotechnology related to antibody engineering (phage displays, combinatorial libraries) and thera-peutic approaches (graft, immunotherapy). IMGT is freely available at http://imgt.cines.fr. PMID:12520009

  17. Subretinal Visual Implant Alpha IMS--Clinical trial interim report.

    PubMed

    Stingl, Katarina; Bartz-Schmidt, Karl Ulrich; Besch, Dorothea; Chee, Caroline K; Cottriall, Charles L; Gekeler, Florian; Groppe, Markus; Jackson, Timothy L; MacLaren, Robert E; Koitschev, Assen; Kusnyerik, Akos; Neffendorf, James; Nemeth, Janos; Naeem, Mohamed Adheem Naser; Peters, Tobias; Ramsden, James D; Sachs, Helmut; Simpson, Andrew; Singh, Mandeep S; Wilhelm, Barbara; Wong, David; Zrenner, Eberhart

    2015-06-01

    A subretinal visual implant (Alpha IMS, Retina Implant AG, Reutlingen, Germany) was implanted in 29 blind participants with outer retinal degeneration in an international multicenter clinical trial. Primary efficacy endpoints of the study protocol were a significant improvement of activities of daily living and mobility to be assessed by activities of daily living tasks, recognition tasks, mobility, or a combination thereof. Secondary efficacy endpoints were a significant improvement of visual acuity/light perception and/or object recognition (clinicaltrials.gov, NCT01024803). During up to 12 months observation time twenty-one participants (72%) reached the primary endpoints, of which thirteen participants (45%) reported restoration of visual function which they use in daily life. Additionally, detection, localization, and identification of objects were significantly better with the implant power switched on in the first 3 months. Twenty-five participants (86%) reached the secondary endpoints. Measurable grating acuity was up to 3.3 cycles per degree, visual acuities using standardized Landolt C-rings were 20/2000, 20/2000, 20/606 and 20/546. Maximal correct motion perception ranged from 3 to 35 degrees per second. These results show that subretinal implants can restore very-low-vision or low vision in blind (light perception or less) patients with end-stage hereditary retinal degenerations. PMID:25812924

  18. Evaluation of infrasonic detection capability for the CTBT/IMS

    SciTech Connect

    Armstrong, W.T.; Whitaker, R.W.; Olson, J.V.

    1996-09-01

    Evaluation of infrasonic detection capability for the International Monitoring System of the Comprehensive Test Ban Treaty (IMS/CTBT) is made with respect to signal analysis and global coverage. Signal analysis is anecdotally reviewed with respect to composite power, correlation and F-statistic detection algorithms. In the absence of adaptive pre-filtering, either cross-correlation or F-statistic detection is required. As an unbounded quantity, the F-statistic offers potentially greater sensitivity to signals of interest. With PURE state pre-filtering, power detection begins to become competitive with correlation and F-statistic detection. Additional application of simple post-filters of minimum duration and maximum bearing deviation results in unique positive detection of an identified impulsive infrasonic signal. Global coverage estimates are performed as a useful deterministic evaluation of networks, offering an easily interpreted network performance, which compliments previous probabilistic network evaluations. In particular, adequate coverage (2 sites), uniform coverage, and redundant coverage (3 to 4 sites) provide figures of merit in evaluating detection, location and vulnerability, respectively. Coverage estimates of the I60 network have been performed which indicate generally adequate coverage for the majority of the globe. Modest increase of station gain (increase of number of elements from 4 to 7) results in significant increase in coverage for mean signal values. Ineffective sites and vulnerability sites are identified which suggest further refinement of the network is possible.

  19. Analyzing Electric Field Morphology Through Data-Model Comparisons of the GEM IM/S Assessment Challenge Events

    NASA Technical Reports Server (NTRS)

    Liemohn, Michael W.; Ridley, Aaron J.; Kozyra, Janet U.; Gallagher, Dennis L.; Thomsen, Michelle F.; Henderson, Michael G.; Denton, Michael H.; Brandt, Pontus C.; Goldstein, Jerry

    2006-01-01

    The storm-time inner magnetospheric electric field morphology and dynamics are assessed by comparing numerical modeling results of the plasmasphere and ring current with many in situ and remote sensing data sets. Two magnetic storms are analyzed, April 22,2001 and October 21-23,2001, which are the events selected for the Geospace Environment Modeling (GEM) Inner Magnetosphere/Storms (IM/S) Assessment Challenge (IMSAC). The IMSAC seeks to quantify the accuracy of inner magnetospheric models as well as synthesize our understanding of this region. For each storm, the ring current-atmosphere interaction model (RAM) and the dynamic global core plasma model (DGCPM) were run together with various settings for the large-scale convection electric field and the nightside ionospheric conductance. DGCPM plasmaspheric parameters were compared with IMAGE-EUV plasmapause extractions and LANL-MPA plume locations and velocities. RAM parameters were compared with Dst*, LANL-MPA fluxes and moments, IMAGE-MENA images, and IMAGE-HENA images. Both qualitative and quantitative comparisons were made to determine the electric field morphology that allows the model results to best fit the plasma data at various times during these events. The simulations with self-consistent electric fields were, in general, better than those with prescribed field choices. This indicates that the time-dependent modulation of the inner magnetospheric electric fields by the nightside ionosphere is quite significant for accurate determination of these fields (and their effects). It was determined that a shielded Volland-Stern field description driven by the 3-hour Kp index yields accurate results much of the time, but can be quite inconsistent. The modified Mcllwain field description clearly lagged in overall accuracy compared to the other fields, but matched some data sets (like Dst*) quite well. The rankings between the simulations varied depending on the storm and the individual data sets, indicating that

  20. NMR investigation of the interaction of the inhibitor protein Im9 with its partner DNase.

    PubMed

    Boetzel, R; Czisch, M; Kaptein, R; Hemmings, A M; James, R; Kleanthous, C; Moore, G R

    2000-09-01

    The bacterial toxin colicin E9 is secreted by producing Escherichia coli cells with its 9.5 kDa inhibitor protein Im9 bound tightly to its 14.5 kDa C-terminal DNase domain. Double- and triple-resonance NMR spectra of the 24 kDa complex of uniformly 13C and 15N labeled Im9 bound to the unlabeled DNase domain have provided sufficient constraints for the solution structure of the bound Im9 to be determined. For the final ensemble of 20 structures, pairwise RMSDs for residues 3-84 were 0.76 +/- 0.14 A for the backbone atoms and 1.36 +/- 0.15 A for the heavy atoms. Representative solution structures of the free and bound Im9 are highly similar, with backbone and heavy atom RMSDs of 1.63 and 2.44 A, respectively, for residues 4-83, suggesting that binding does not cause a major conformational change in Im9. The NMR studies have also allowed the DNase contact surface on Im9 to be investigated through changes in backbone chemical shifts and NOEs between the two proteins determined from comparisons of 1H-1H-13C NOESY-HSQC spectra with and without 13C decoupling. The NMR-defined interface agrees well with that determined in a recent X-ray structure analysis with the major difference being that a surface loop of Im9, which is at the interface, has a different conformation in the solution and crystal structures. Tyr54, a key residue on the interface, is shown to exhibit NMR characteristics indicative of slow rotational flipping. A mechanistic description of the influence binding of Im9 has on the dynamic behavior of E9 DNase, which is known to exist in two slowly interchanging conformers in solution, is proposed. PMID:11045617

  1. NMR investigation of the interaction of the inhibitor protein Im9 with its partner DNase.

    PubMed Central

    Boetzel, R.; Czisch, M.; Kaptein, R.; Hemmings, A. M.; James, R.; Kleanthous, C.; Moore, G. R.

    2000-01-01

    The bacterial toxin colicin E9 is secreted by producing Escherichia coli cells with its 9.5 kDa inhibitor protein Im9 bound tightly to its 14.5 kDa C-terminal DNase domain. Double- and triple-resonance NMR spectra of the 24 kDa complex of uniformly 13C and 15N labeled Im9 bound to the unlabeled DNase domain have provided sufficient constraints for the solution structure of the bound Im9 to be determined. For the final ensemble of 20 structures, pairwise RMSDs for residues 3-84 were 0.76 +/- 0.14 A for the backbone atoms and 1.36 +/- 0.15 A for the heavy atoms. Representative solution structures of the free and bound Im9 are highly similar, with backbone and heavy atom RMSDs of 1.63 and 2.44 A, respectively, for residues 4-83, suggesting that binding does not cause a major conformational change in Im9. The NMR studies have also allowed the DNase contact surface on Im9 to be investigated through changes in backbone chemical shifts and NOEs between the two proteins determined from comparisons of 1H-1H-13C NOESY-HSQC spectra with and without 13C decoupling. The NMR-defined interface agrees well with that determined in a recent X-ray structure analysis with the major difference being that a surface loop of Im9, which is at the interface, has a different conformation in the solution and crystal structures. Tyr54, a key residue on the interface, is shown to exhibit NMR characteristics indicative of slow rotational flipping. A mechanistic description of the influence binding of Im9 has on the dynamic behavior of E9 DNase, which is known to exist in two slowly interchanging conformers in solution, is proposed. PMID:11045617

  2. The GBT-SerDes ASIC prototype

    NASA Astrophysics Data System (ADS)

    Moreira, P.; Baron, S.; Bonacini, S.; Cobanoglu, O.; Faccio, F.; Feger, S.; Francisco, R.; Gui, P.; Li, J.; Marchioro, A.; Paillard, C.; Porret, D.; Wyllie, K.

    2010-11-01

    In the framework of the GigaBit Transceiver project (GBT), a prototype, the GBT-SerDes ASIC, was developed, fabricated and tested. To sustain high radiation doses while operating at 4.8Gb/s, the ASIC was fabricated in a commercial 130 nm CMOS technology employing radiation tolerant techniques and circuits. The transceiver serializes-deserializes the data, Reed-Solomon encodes and decodes the data and scrambles and descrambles the data for transmission over optical fibre links. This paper describes the GBT-SerDes architecture, and presents the test results.

  3. IM-133N modulates cytokine secretion by RAW264.7 and THP-1 cells.

    PubMed

    Varma, R Sandeep; Guruprasad, Kanive P; Satyamoorthy, Kapaettu; Kumar, L M Sharath; Babu, U Venkanna; Patki, S Pralhad

    2016-01-01

    An indigenous herbal extract IM-133N containing extracts of Prosopis glandulosa Torr and Symplocos racemosa Roxb were evaluated for potential immunomodulatory effects using RAW264.7 and THP-1 cells. The incubation of the cells for 24 h with IM-133N over a dose range 0-125 µg/ml did not cause cytotoxicity that exceeded 10%. The results indicated that non-cytotoxic doses of IM-133N effectively up-regulated iNOS, TNFα, IL-6, IL-10, IL-8 and IFNγ gene expression in both the RAW264.7 and THP-1 cells. The results also indicated IM-133N elicited dose-related increases in nitric oxide (NO) and tumor necrosis factor (TNF)-α production by RAW264.7 or THP-1 cells. These results demonstrated that IM-133N could stimulate NO and induced pro-inflammatory cytokine expression by monocytes/macrophages. As clinical studies have shown IM-133N to be an effective immunomodulator without any adverse effects, the results of the present study provide further support for the potential use of this agent as an immunostimulant or as an immunotherapy adjuvant. PMID:25975427

  4. Metabolic Profiling of Human Blood by High Resolution Ion Mobility Mass Spectrometry (IM-MS)

    PubMed Central

    Dwivedi, Prabha; Schultz, Albert J.; Hill, Herbert H.

    2010-01-01

    A high resolution ion mobility time-of-flight mass spectrometer with electrospray ionization source (ESI-IM-MS) was evaluated as an analytical method for rapid analysis of complex biological samples such as human blood metabolome was investigated. The hybrid instrument (IM-MS) provided an average ion mobility resolving power of ~90 and a mass resolution of ~1500 (at m/z 100). A few µL of whole blood was extracted with methanol, centrifuged and infused into the IM-MS via an electrospray ionization source. Upon IM-MS profiling of the human blood metabolome approximately 1,100 metabolite ions were detected and 300 isomeric metabolites separated in short analyses time (30 minutes). Estimated concentration of the metabolites ranged from the low micromolar to the low nanomolar level. Various classes of metabolites (amino acids, organic acids, fatty acids, carbohydrates, purines and pyrimidines etc) were found to form characteristic mobility-mass correlation curves (MMCC) that aided in metabolite identification. Peaks corresponding to various sterol derivatives, estrogen derivatives, phosphocholines, prostaglandins, and cholesterol derivatives detected in the blood extract were found to occupy characteristic two dimensional IM-MS space. Low abundance metabolite peaks that can be lost in MS random noise were resolved from noise peaks by differentiation in mobility space. In addition, the peak capacity of MS increased six fold by coupling IMS prior to MS analysis. PMID:21113320

  5. Determination of volatile compounds by GC-IMS to assign the quality of virgin olive oil.

    PubMed

    Garrido-Delgado, Rocío; Dobao-Prieto, María del Mar; Arce, Lourdes; Valcárcel, Miguel

    2015-11-15

    The characterisation of different olive oil categories (extra virgin, virgin and lampante) using Ion Mobility Spectrometry (IMS) was improved by replacing the multicapillary column (MCC) with a capillary column (CC). The data obtained with MCC-IMS and CC-IMS were evaluated, studying both the global and the specific information obtained after the analysis of the volatile fraction of olive oils. A better differentiation of the oil categories was obtained employing CC vs MCC, since the classification percentage obtained with the CC-IMS was 92% as opposed to 87% obtained with MCC-IMS; although in productivity analytical terms, MCC offer a faster analysis than GC. The specific information obtained was also used to build a database, with a view to facilitating the characterization of specific attributes of olive oils. A total of 26 volatile metabolites (aldehydes, ketones, alcohols and esters) were identified. Finally, as revealed by an ANOVA test, some volatiles differed markedly in content among the different categories of oil. The data obtained confirms the potential of IMS as a reliable analytical screening technique, which can be used to assign the correct category to an olive oil sample. PMID:25977065

  6. Integriertes Informationsmanagement am KIT Was bleibt? Was kommt?

    NASA Astrophysics Data System (ADS)

    Labitzke, Sebastian; Nussbaumer, Martin; Hartenstein, Hannes; Juling, Wilfried

    Der Beitrag beschreibt wesentliche seit dem Jahr 2005 an der Universität Karlsruhe bzw. am Karlsruher Institut für Technologie erzielte Ergebnisse in Bezug auf technische und organisatorische Integration für das Informationsmanagement. Insbesondere stehen die Portaldienste und das Identitätsmanagement im Fokus der technischen Innovation. Daneben werden zwei organisatorische Innovationen vorgestellt, die sich dediziert Fragestellungen zur IT-Governance und IT-Compliance widmen. Abschließend werden erzielte Schlüsselerfahrungen diskutiert, die im Zuge des Aufbaus eines integrierten Informationsmanagements gemacht wurden. Ausblickend wollen wir einen Bezug zu den allgegenwärtigen Problemstellungen und verbundenen Herausforderungen derartiger Vorhaben aufzeigen - Herausforderungen, die waren, sind und bleiben werden.

  7. Developpement des betons semi autoplacants a rheologie adaptee pour des infrastructures

    NASA Astrophysics Data System (ADS)

    Sotomayor Cruz, Cristian Daniel

    Au cours des dernières décennies, les infrastructures canadiennes et québécoises comportent plusieurs structures en béton armé présentant des problèmes de durabilité dus aux conditions climatiques sévères, à la mauvaise conception des structures, à la qualité des matériaux, aux types des bétons choisis, aux systèmes de construction ou à l'existence d'événements incontrôlables. En ce qui concerne le choix du béton pour la construction des infrastructures, une vaste gamme de béton divisée en deux principaux types peut être utilisée: le béton conventionnel vibré (BCV) et le béton autoplaçant (BAP). Dans le cas d'un BCV, la consolidation inadéquate par vibration a été un problème récurrent, occasionnant des dommages structuraux. Ceci a conduit à une réduction de la durabilité et à une augmentation du coût d'entretien et de réparation des infrastructures. Rien que l'utilisation d'un BAP a des avantages tels que l'élimination de la vibration, la réduction des coûts de main d'oeuvre et l'amélioration de la qualité des structures, néanmoins, le coût initial d'un BAP par rapport à un BCV ne permet pas encore de généraliser son utilisation dans l'industrie de la construction. Ce mémoire présente la conception d'une nouvelle gamme de béton semi-autoplaçant pour la construction des infrastructures (BSAP-I) exigeant une vibration minimale. Il s'agit de trouver un équilibre optimal entre la rhéologie et le coût initial du nouveau béton pour conférer une bonne performance structurale et économique aux structures. Le programme expérimental établi a premièrement permis d'évaluer la faisabilité d'utilisation des BSAP-I pour la mise en place des piliers d'une infrastructure de pont à Sherbrooke. En plus, l'utilisation d'un plan d'expériences a permis l'évaluation de trois paramètres de formulation sur les propriétés des mélanges de BSAP-I à l'état frais et durci. Finalement, l'évaluation de la performance des

  8. Etude theorique et experimentale des evaporateurs de dioxyde de carbone operant dans des conditions de givrage

    NASA Astrophysics Data System (ADS)

    Bendaoud, Adlane Larbi

    Les evaporateurs de refrigeration sont surtout du type tube a ailettes, appeles serpentins, et fonctionnent dans l'une des conditions suivantes: seche, humide ou avec formation de givre. Il a ete demontre que la formation du givre sur la paroi exterieure de l'echangeur engendre une surconsommation energetique a cause des operations de degivrage puisque 15 a 20% seulement de la chaleur produite sert au degivrage tandis que le reste est dissipee dans l'environnement [1]. Avec l'avenement des nouveaux refrigerants, moins nocifs envers l'environnement, l'industrie du froid se trouve penalisee du fait que peu ou pas de composantes mecaniques (compresseur, pompe, echangeur...etc.) adaptees sont disponibles [3]. Il s'agit pour la communaute des frigoristes de combler ce retard technologique en redeveloppant ces composantes mecaniques afin qu'elles soient adaptees aux nouveaux refrigerants. Dans cette optique, et afin de mieux comprendre le comportement thermique des evaporateurs au CO2 fonctionnant dans des conditions seches, qu'un groupe de chercheurs du CanmetENERGIE avaient lance, en 2000, un programme de R & D. Dans le cadre de programme un outil de simulation des evaporateurs au CO2 a ete developpe et un banc d'essai contenant une boucle secondaire de refrigeration utilisant le CO2 comme refrigerant a ete construit. Comme continuite de ce travail de recherche, en 2006 ce meme groupe de recherche a lance un nouveau projet qui consiste a faire une etude theorique et experimentale des evaporateurs au CO2 operants dans des conditions de givrage. Et, c'est exactement dans le cadre de ce projet que se positionne ce travail de these. Ce travail de recherche a ete entrepris pour mieux comprendre le comportement thermique et hydrodynamique des serpentins fonctionnant dans des conditions de givrage, l'effet des circuits de refrigerant ainsi que celui des parametres geometriques et d'operation. Pour cela, un travail theorique supporte par une etude experimentale a ete effectue

  9. Effets des electrons secondaires sur l'ADN

    NASA Astrophysics Data System (ADS)

    Boudaiffa, Badia

    Les interactions des electrons de basse energie (EBE) representent un element important en sciences des radiations, particulierement, les sequences se produisant immediatement apres l'interaction de la radiation ionisante avec le milieu biologique. Il est bien connu que lorsque ces radiations deposent leur energie dans la cellule, elles produisent un grand nombre d'electrons secondaires (4 x 104/MeV), qui sont crees le long de la trace avec des energies cinetiques initiales bien inferieures a 20 eV. Cependant, il n'y a jamais eu de mesures directes demontrant l'interaction de ces electrons de tres basse energie avec l'ADN, du principalement aux difficultes experimentales imposees par la complexite du milieu biologique. Dans notre laboratoire, les dernieres annees ont ete consacrees a l'etude des phenomenes fondamentaux induits par impact des EBE sur differentes molecules simples (e.g., N2, CO, O2, H2O, NO, C2H 4, C6H6, C2H12) et quelques molecules complexes dans leur phase solide. D'autres travaux effectues recemment sur des bases de l'ADN et des oligonucleotides ont montre que les EBE produisent des bris moleculaires sur les biomolecules. Ces travaux nous ont permis d'elaborer des techniques pour mettre en evidence et comprendre les interactions fondamentales des EBE avec des molecules d'interet biologique, afin d'atteindre notre objectif majeur d'etudier l'effet direct de ces particules sur la molecule d'ADN. Les techniques de sciences des surfaces developpees et utilisees dans les etudes precitees peuvent etre etendues et combinees avec des methodes classiques de biologie pour etudier les dommages de l'ADN induits par l'impact des EBE. Nos experiences ont montre l'efficacite des electrons de 3--20 eV a induire des coupures simple et double brins dans l'ADN. Pour des energies inferieures a 15 eV, ces coupures sont induites par la localisation temporaire d'un electron sur une unite moleculaire de l'ADN, ce qui engendre la formation d'un ion negatif transitoire

  10. The "Conservatoire National des Arts et Metiers"

    ERIC Educational Resources Information Center

    Kuhn, Gerard

    2004-01-01

    The overall mission of the Conservatoire national des arts et metiers--(CNAM) [National Conservatory of Industrial Arts and Trades] is outlined. One of its centers, the "Centre national de l'entrepreneuriat"--(CNE) [National Center for Entrepreneurship] is described in greater detail. In particular, this center offers various services, notably…

  11. Fiabilité des structures mécaniques adaptatives: effet de la panne des actionneurs ou des capteurs sur la stabilité

    NASA Astrophysics Data System (ADS)

    Fall, H.; Charon, W.; Kouta, R.

    2002-12-01

    Ces dernières décennies, des activités significatives dans le monde étaient dirigées autour du contrôle actif. Le but de ces recherches était essentiellement d'améliorer les performances, la fiabilité et la sécurité des systèmes. Notamment dans le cas des structures soumises à des vibrations aléatoires. D'importants travaux ont été consacré à l'utilisation des “matériaux intelligents” comme capteurs et actionneurs. Cette article propose l'analyse de la fiabilité des systèmes mécaniques en étudiant les pannes des actionneurs ou des capteurs. L'effet de ces pannes sur la stabilité et la performance du système y est démontré. Les méthodologies de conception y sont rappelées. Des exemples numériques sont fournis à travers le contrôle d'un panneau sous chargement dynamique pour illustrer la méthode proposée.

  12. Improved Detection of Mycobacterium bovis Infection in Bovine Lymph Node Tissue Using Immunomagnetic Separation (IMS)-Based Methods

    PubMed Central

    Stewart, Linda D.; McNair, James; McCallan, Lyanne; Gordon, Alan; Grant, Irene R.

    2013-01-01

    Immunomagnetic separation (IMS) can selectively isolate and concentrate Mycobacterium bovis cells from lymph node tissue to facilitate subsequent detection by PCR (IMS-PCR) or culture (IMS-MGIT). This study describes application of these novel IMS-based methods to test for M. bovis in a survey of 280 bovine lymph nodes (206 visibly lesioned (VL), 74 non-visibly lesioned (NVL)) collected at slaughter as part of the Northern Ireland bovine TB eradication programme. Their performance was evaluated relative to culture. Overall, 174 (62.1%) lymph node samples tested positive by culture, 162 (57.8%) by IMS-PCR (targeting IS6110), and 191 (68.2%) by IMS-MGIT culture. Twelve (6.9%) of the 174 culture positive lymph node samples were not detected by either of the IMS-based methods. However, an additional 79 M. bovis positive lymph node samples (27 (13.1%) VL and 52 (70.3%) NVL) were detected by the IMS-based methods and not by culture. When low numbers of viable M. bovis are present in lymph nodes (e.g. in NVLs of skin test reactor cattle) decontamination prior to culture may adversely affect viability, leading to false negative culture results. In contrast, IMS specifically captures whole M. bovis cells (live, dead or potentially dormant) which are not subject to any deleterious treatment before detection by PCR or MGIT culture. During this study only 2.7% of NVL lymph nodes tested culture positive, whereas 70.3% of the same samples tested M. bovis positive by the IMS-based tests. Results clearly demonstrate that not only are the IMS-based methods more rapid but they have greater detection sensitivity than the culture approach currently used for the detection of M. bovis infection in cattle. Adoption of the IMS-based methods for lymph node testing would have the potential to improve M. bovis detection in clinical samples. PMID:23469275

  13. Profil epidemiologique des brulures d'enfants admis au Centre National des Brules, Maroc

    PubMed Central

    Zahid, A.; Atannaz, J.; Alaoui, M.; Rafik, A.; Ezzoubi, M.; Diouri, M.; Chlihi, A.; Bahechar, N.; Boukind, E.H.

    2011-01-01

    Summary Ce travail rétrospectif analyse les particularités épidémiologiques de 543 cas de brûlures d'enfants, représentant 45,7% des admissions de notre centre, en vue de déterminer les éléments pouvant contribuer à renforcer la prévention, qui reste le traitement de choix de cette pathologie. La moyenne d'âge est de 4,25 ans avec une prédilection pour la tranche d'âge d'un à cinq ans, avec 42,5% des cas. Une atteinte masculine est retrouvée dans 63,5% des cas. La brûlure survient à domicile dans 85,1% et accidentellement dans 95% des cas. Les brûlures thermiques représentent 96,5% des causes dominées par les liquides dans 69,3% des cas. La surface cutanée brûlée est ≥ 20% dans 52,3%. La brûlure intéresse essentiellement les membres supérieurs (79,1%). 56,8% des enfants sont transférés par d'autres hôpitaux et le délai de prise en charge hospitalière est supérieur à 6 heures dans 65,5%. Le taux de mortalité a été de 13,2%. PMID:22639559

  14. Data collection in IMS: It's not as easy as it looks

    NASA Technical Reports Server (NTRS)

    Davis, Dennis M.; Maswadeh, Waleed; Shoff, Donald B.; Harden, Charles S.; Snyder, A. Peter

    1995-01-01

    Data collection in Ion Mobility Spectrometry (IMS) is not as easy an endeavor as it appears. Despite the advent of high speed personal computers and fast analog-to-digital converters (ADC's), care must be taken to ensure that reliable data are obtained in a timely fashion. This is especially true in hyphenated techniques, e.g. GC-IMS, where the amount of data increases dramatically when gas chromatography-ion mobility spectrometry (GC-IMS) data is being collected. Using the Graseby GC-IMS, with a gate repetition rate of 33 Hz, it is theoretically possible to collect 33 spectra per second. This collection rate is not realistically obtained due to a number of factors. Among these factors are inaccuracy of the timing signal from the IMS, the necessity to store the data, disk input/output limitations, disk operating system limitations, and program overhead. Taking these factors into account, we have achieved a data collection rate of 20 spectra per second. This paper will describe these problems, demonstrate the practical effects these problems present, and present methods for minimizing these effects.

  15. Applied Doppler Imaging: Can Magnetic Activity of IM Pegasi Affect the Gravity Probe B Mission?

    NASA Astrophysics Data System (ADS)

    Berdyugina, S. V.; Marsden, S. C.

    2006-12-01

    IM Peg is a single-lined, spectroscopic RS CVn binary, with a rapidly rotating (v sin i=27 km/s), early K-type, giant primary. Magnetic activity of the primary is indicated by dark spots covering > 15% of the surface. The system is bright in both optical and radio, and was chosen as a guide star for the Gravity Probe B (GP-B) satellite mission. The goal of GP-B is to verify two predictions of Einstein's theory of general relativity (geodetic effect and ``frame dragging''), based on measurements of mean gyroscopic drift with respect to the optical centroid of IM Peg. The requested precision of 0.5×10-3 arcsec/yr implies that even small shifts of the optical centroid of IM Peg due to surface magnetic activity must be determined. In support of the GP-B mission, we are undertaking an intensive Doppler imaging survey of the primary component of IM Peg, to determine the effect of spot features on its optical centroid. We present an overview of our work for GP-B, and report initial results from this support project, including the first magnetic maps of the IM~Peg primary, created using Least-Squares Deconvolution and Zeeman Doppler Imaging.

  16. Les effets des interfaces sur les proprietes magnetiques et de transport des multicouches nickel/iron et cobalt/silver

    NASA Astrophysics Data System (ADS)

    Veres, Teodor

    Cette these est consacree a l'etude de l'evolution structurale des proprietes magnetiques et de transport des multicouches Ni/Fe et nanostructures a base de Co et de l'Ag. Dans une premiere partie, essentiellement bibliographique, nous introduisons quelques concepts de base relies aux proprietes magnetiques et de transport des multicouches metalliques. Ensuite, nous presentons une breve description des methodes d'analyse des resultats. La deuxieme partie est consacree a l'etude des proprietes magnetiques et de transport des multicouches ferromagnetiques/ferromagnetiques Ni/Fe. Nous montrerons qu'une interpretation coherente de ces proprietes necessite la prise en consideration des effets des interfaces. Nous nous attacherons a mettre en evidence, a evaluer et a etudier les effets de ces interfaces ainsi que leur evolution, et ce, suite a des traitements thermiques tel que le depot a temperature elevee et l'irradiation ionique. Les analyses correlees de la structure et de la magnetoresistance nous permettront d'emettre des conclusions sur l'influence des couches tampons entre l'interface et le substrat ainsi qu'entre les couches elles-memes sur le comportement magnetique des couches F/F. La troisieme partie est consacree aux systemes a Magneto-Resistance Geante (MRG) a base de Co et Ag. Nous allons etudier l'evolution de la microstructure suite a l'irradiation avec des ions Si+ ayant une energie de 1 MeV, ainsi que les effets de ces changements sur le comportement magnetique. Cette partie debutera par l'analyse des proprietes d'une multicouche hybride, intermediaire entre les multicouches et les materiaux granulaires. Nous analyserons a l'aide des mesures de diffraction, de relaxation superparamagnetique et de magnetoresistance, les evolutions structurales produites par l'irradiation ionique. Nous etablirons des modeles qui nous aideront a interpreter les resultats pour une serie des multicouches qui couvrent un large eventail de differents comportements magnetiques

  17. Etude du processus de changement vecu par des familles ayant decide d'adopter volontairement des comportements d'attenuation des changements climatiques

    NASA Astrophysics Data System (ADS)

    Leger, Michel T.

    Les activites humaines energivores telles l'utilisation intensive de l'automobile, la surconsommation de biens et l'usage excessif d'electricite contribuent aux changements climatiques et autres problemes environnementaux. Bien que plusieurs recherches rapportent que l'etre humain est de plus en plus conscient de ses impacts sur le climat de la planete, ces memes recherches indiquent qu'en general, les gens continuent a se comporter de facon non ecologique. Que ce soit a l'ecole ou dans la communaute, plusieurs chercheurs en education relative a l'environnement estiment qu'une personne bien intentionnee est capable d'adopter des comportements plus respectueux de l'environnement. Le but de cette these etait de comprendre le processus d'integration de comportements d'attenuation des changements climatiques dans des familles. A cette fin, nous nous sommes fixe deux objectifs : 1) decrire les competences et les procedes qui favorisent l'adoption de comportements d'attenuation des changements climatiques dans des familles et 2) decrire les facteurs et les dynamiques familiales qui facilitent et limitent l'adoption de comportements d'attenuation des changements climatiques dans des familles. Des familles ont ete invitees a essayer des comportements personnels et collectifs d'attenuation des changements climatiques de sorte a integrer des modes de vie plus ecologiques. Sur une periode de huit mois, nous avons suivi leur experience de changement afin de mieux comprendre comment se produit le processus de changement dans des familles qui decident volontairement d'adopter des comportements d'attenuation des changements climatiques. Apres leur avoir fourni quelques connaissances de base sur les changements climatiques, nous avons observe le vecu de changement des familles durant huit mois d'essais a l'aide de journaux reflexifs, d'entretiens d'explicitation et du journal du chercheur. La these comporte trois articles scientifiques. Dans le premier article, nous presentons une

  18. Community Environmental Response Facilitation Act (CERFA) report. Fort Des Moines, Des Moines, Iowa. Final report

    SciTech Connect

    Young, B.; Rausch, K.; Kang, J.

    1994-04-01

    This report presents the results of the Community Environmental Response Facilitation Act (CERFA) investigation conducted by The Earth Technology Corporation (TETC) at the Fort Des Moines, a U.S. Government property selected for closure by the Base Realignment and Closure (BRAC) Commission. Under CERFA Federal agencies are required to identify real property that can be immediately reused and redeveloped. Satisfying this objective requires the identification of real property where no hazardous substances or petroleum products, regulated by the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), were stored for one year or more, known to have been released, or disposed. Fort Des Moines is a 53.28-acre site located in Polk County, Iowa, within the city limits of Des Moines. The installation's primary mission is to provide support and shelter for the U.S. Army Reserve. Activities associated with the property that have environmental significance are photographic processing, vehicle maintenance, printing, and fuel storage. TETC reviewed existing investigation documents; U.S. Environmental Protection Agency (USEPA), State, and county regulatory records; environmental data bases; and title documents pertaining to Fort Des Moines during this investigation. In addition, TETC conducted interviews and visual inspections of Fort Des Moines as well as visual inspections and data base searches for the surrounding properties. Information in this CERFA Report was current as of April 1994.

  19. Etude des phenomenes de penetration des especes chimiques dans les revetements cathodiques des cuves d'electrolyse de l'aluminium

    NASA Astrophysics Data System (ADS)

    Brisson, Pierre-Yves

    Cette these decrit l'etude effectuee sur les phenomenes d'insertion du sodium et de penetration du bain electrolytique dans les revetements cathodiques des cuves d'electrolyse de l'aluminium. L'etude fut effectuee a l'aide d'un montage permettant d'effectuer l'electrolyse en laboratoire. Trois types de revetement cathodiques furent etudies : des blocs semi-graphitique, des blocs graphitiques et des blocs graphitises. L'insertion du sodium dans les trois differents types de blocs fut etudiee a l'aide de la spectrometrie des photoelectrons X (XPS). L'analyse a permis de mettre en evidence deux formes de sodium dans l'anthracite et la phase liante des materiaux semi-graphitiques et graphitiques, indiquant qu'une fraction du sodium se retrouve sous forme adsorbee dans les micropores des materiaux alors que l'autre fraction est inseree dans la structure cristalline du carbone. Dans les phases graphitiques (materiaux graphitises et graphitiques), seuls les micropores sont occupes par le sodium Ce resultat explique la tendance observee selon laquelle l'ajout de graphite dans les blocs permet d'abaisser le gonflement sodique. Les mecanismes de penetration du bain dans le reseau poreux des materiaux furent etudies en microscopie electronique et en diffraction des rayons X sur des echantillons apres differents temps d'electrolyses et en variant l'atmosphere (soit sous argon ou sous azote). Ces analyses ont permis d'identifier le mecanisme conduisant a la mouillabilite du bain sur le carbone en fonction de l'atmosphere entourant l'electrolyse. Ainsi, sous azote, la formation de NaCN dans les pores des materiaux par reactions entre le sodium et l'azote permet une mouillabilite accrue du bain alors qu'en absence d'azote (sous argon), le carbure d'aluminium, formes a la surface des pores, joue un role similaire. Dans ce dernier cas, la penetration du bain est moins rapide etant donnee la necessite de toujours amener des especes contenant de l'aluminium en tete du front de

  20. imCast: Studio-Quality Digital Media Platform Exploiting Broadband IP Networks

    NASA Astrophysics Data System (ADS)

    Jo, Jinyong; Kim, Jongwon

    The recent growth in available network bandwidth envisions the wide-spread use of broadband applications such as uncompressed HD-SDI (High-definition serial digital interface) over IP. These cutting-edge applications are also driving the development of a media-oriented infrastructure for networked collaboration. This paper introduces imCast, a high-quality digital media platform dealing with uncompressed HD-SDI over IP, and discusses its internal architecture in depth. imCast mainly provides cost-effective hardware-based approaches for high-quality media acquisition and presentation; flexible software-based approaches for presentation; and allows for economical network transmission. Experimental results (taken over best-effort IP networks) will demonstrate the functional feasibility and performance of imCast.

  1. Multiwavelength Observations of Two Moderate Rotation RS CVn Systems: V815 Herculis and IM Pegasi

    NASA Astrophysics Data System (ADS)

    Dempsey, Robert C.; Neff, James E.; O'Neal, Douglas; Olah, Katalin

    1996-03-01

    Near-to-simultaneous ultraviolet and visual spectroscopy of two moderate v sin i RS CVn systems, V815 Herculis (v sin i=27 km s-1) and IM Pegasi (v sin i=24 km s-1), are presented along with contemporaneous UBV(RI)c photometry. These data were used to probe inhomogeneities in the chromospheres and photospheres, and the possible relationship between them. Variability is observed at all wavelengths, some indicators showing rotationally modulated fluctuations. We use UBVRI photometry and TiO spectra to estimate temperatures, area, and locations of photospheric spots on IM Peg. Evidence is presented that the spot temperature in IM Peg has changed over a possible solar-like spot cycle. Radial velocities of V815 Her indicates that the system is actually triple.

  2. An IMS Station life cycle from a sustainment point of view

    NASA Astrophysics Data System (ADS)

    Brely, Natalie; Gautier, Jean-Pierre; Foster, Daniel

    2014-05-01

    The International Monitoring System (IMS) is to consist of 321 monitoring facilities, composed of four different technologies with a variety of designs and equipment types, deployed in a range of environments around the globe. The International Monitoring System is conceived to operate in perpetuity through maintenance, replacement and recapitalization of IMS facilities' infrastructure and equipment when the end of service life is reached [CTBT/PTS/INF.1163]. Life Cycle techniques and modellization are being used by the PTS to plan and forecast life cycle sustainment requirements of IMS facilities. Through historical data analysis, Engineering inputs and Feedback from experienced Station Operators, the PTS currently works towards increasing the level of confidence on these forecasts and sustainment requirements planning. Continued validation, feedback and improvement of source data from scientific community and experienced users is sought and essential in order to ensure limited effect on data availability and optimal costs (human and financial).

  3. Down-conversion IM-DD RF photonic link utilizing MQW MZ modulator.

    PubMed

    Xu, Longtao; Jin, Shilei; Li, Yifei

    2016-04-18

    We present the first down-conversion intensity modulated-direct detection (IM-DD) RF photonic link that achieves frequency down-conversion using the nonlinear optical phase modulation inside a Mach-Zehnder (MZ) modulator. The nonlinear phase modulation is very sensitive and it can enable high RF-to-IF conversion efficiency. Furthermore, the link linearity is enhanced by canceling the nonlinear distortions from the nonlinear phase modulation and the MZ interferometer. Proof-of-concept measurement was performed. The down-conversion IM-DD link demonstrated 28dB improvement in distortion levels over that of a conventional IM-DD link using a LiNbO3 MZ modulator. PMID:27137278

  4. Sequence and properties of pIM13, a macrolide-lincosamide-streptogramin B resistance plasmid from Bacillus subtilis.

    PubMed Central

    Monod, M; Denoya, C; Dubnau, D

    1986-01-01

    We initiated a study of pIM13, a multicopy, macrolide-lincosamide-streptogramin B (MLS) plasmid first isolated from a strain of Bacillus subtilis and described by Mahler and Halvorson (J. Gen. Microbiol. 120:259-263, 1980). The copy number of this plasmid was about 200 in B. subtilis and 30 in Staphylococcus aureus. The MLS resistance determinant of pIM13 was shown to be highly homologous to ermC, an inducible element on the S. aureus plasmid pE194. The product of the pIM13 determinant was similar in size to that of ermC and immunologically cross-reactive with it. The MLS resistance of pIM13 was expressed constitutively. The complete base sequence of pIM13 is presented. The plasmid consisted of 2,246 base pairs and contained two open reading frames that specified products identified in minicell extracts. One was a protein of 16,000 molecular weight, possibly required for replication. The second was the 29,000-molecular-weight MLS resistance methylase. The regulatory region responsible for ermC inducibility was missing from pIM13, explaining its constitutivity. The remainder of the pIM13 MLS determinant was nearly identical to ermC. The ends of the region of homology between pIM13 and pE194 were associated with hyphenated dyad symmetries. A segment partially homologous to one of these termini on pIM13 and also associated with a dyad was found in pUB110 near the end of a region of homology between that plasmid and pBC16. The entire sequence of pIM13 was highly homologous to that of pE5, an inducible MLS resistance plasmid from S. aureus that differs from pIM13 in copy control. Images PMID:3087948

  5. TRANSPLANTATION EN MASSE DES ORGANES ABDOMINAUX

    PubMed Central

    STARZL, T.

    2010-01-01

    Les transplantations multi-organes, comprenant les blocs foie-duodénum-pancréas, foie-estomac-duodénum-pancréas, et foie-intestin sont réalisées avec un succés croissant Ces techniques et leurs combinaisons variées de transplantation monobloc ne sont pas de pratique courante. Les techniques de prélévement, de conservation et de soins post-opératoires sont décrites pour la transplantation multi-organes compléte ainsi que pour les variantes incomplétes. Le probléme particulier à ce type de transplantation est celui de la transplantation intestinale, c’est-à-dire la transplantation d’un organe à composante lymphoréticulaire complexe ce qui peut provoquer un syndrome greffon contre hôte. Par erreur de conception, et un peu par esprit de systéme, les efforts par le passé étaient dirigés sur la modification et la destruction des systémes lymphoréticulaires grâce au traitement préalable du donneur ou des organes transplantés, par médicaments, radiation ou autres moyens. Actuellement, I’idée directrice est de garder intacte les systémes lymphoréticulaires qui deviennent alors le site d’une circulation à double sens aprés transplantation. Avec la puissante immunodépression que fournit le FK 506, les cellules lymphoréticulaires du donneur peuvent circuler chez le receveur sans créer de syndrome du greffon contre hôte clinique et les cellules de la greffe s’assimilent à celles du receveur (chimérisme local) sans provoquer de rejet. Même si I’on évite le rejet ou le syndrome greffon contre hôte, il existe, à côté de ces entités, des relations métaboliques entre les organes greffés ainsi qu’entre les organes greffés et les viscéres du receveur laissés en place, qui peuvent influencer I’avenir soit des organes greffés, soit des organes laissés en place. Parmi les échanges métaboliques les mieux connus actuellement, il y a les facteurs splanchniques hépatotrophes endogénes, dont I’insuline est la mieux

  6. An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies

    PubMed Central

    Baker, Erin Shammel; Livesay, Eric A.; Orton, Daniel J.; Moore, Ronald J.; Danielson, William F.; Prior, David C.; Ibrahim, Yehia M.; LaMarche, Brian L.; Mayampurath, Anoop M.; Schepmoes, Athena A.; Hopkins, Derek F.; Tang, Keqi; Smith, Richard D.; Belov, Mikhail E.

    2010-01-01

    A high-throughput approach and platform using 15 minute reversed-phase capillary liquid chromatography (RPLC) separations in conjunction with ion mobility spectrometry-mass spectrometry (IMS-MS) measurements was evaluated for the rapid analysis of complex proteomics samples. To test the separation quality of the short LC gradient, a sample was prepared by spiking twenty reference peptides at varying concentrations from 1 ng/mL to 10 µg/mL into a tryptic digest of mouse blood plasma and analyzed with both a LC-Linear Ion Trap Fourier Transform (FT) MS and LC-IMS-TOF MS. The LC-FT MS detected thirteen out of the twenty spiked peptides that had concentrations ≥100 ng/mL. In contrast, the drift time selected mass spectra from the LC-IMS-TOF MS analyses yielded identifications for nineteen of the twenty peptides with all spiking levels present. The greater dynamic range of the LC-IMS-TOF MS system could be attributed to two factors. First, the LC-IMS-TOF MS system enabled drift time separation of the low concentration spiked peptides from the high concentration mouse peptide matrix components, reducing signal interference and background, and allowing species to be resolved that would otherwise be obscured by other components. Second, the automatic gain control (AGC) in the linear ion trap of the hybrid FT MS instrument limits the number of ions that are accumulated to reduce space charge effects and achieve high measurement accuracy, but in turn limits the achievable dynamic range compared to the IMS-TOF instrument. PMID:20000344

  7. Nanomaterial size distribution analysis via liquid nebulization coupled with ion mobility spectrometry (LN-IMS).

    PubMed

    Jeon, Seongho; Oberreit, Derek R; Van Schooneveld, Gary; Hogan, Christopher J

    2016-02-21

    We apply liquid nebulization (LN) in series with ion mobility spectrometry (IMS, using a differential mobility analyzer coupled to a condensation particle counter) to measure the size distribution functions (the number concentration per unit log diameter) of gold nanospheres in the 5-30 nm range, 70 nm × 11.7 nm gold nanorods, and albumin proteins originally in aqueous suspensions. In prior studies, IMS measurements have only been carried out for colloidal nanoparticles in this size range using electrosprays for aerosolization, as traditional nebulizers produce supermicrometer droplets which leave residue particles from non-volatile species. Residue particles mask the size distribution of the particles of interest. Uniquely, the LN employed in this study uses both online dilution (with dilution factors of up to 10(4)) with ultra-high purity water and a ball-impactor to remove droplets larger than 500 nm in diameter. This combination enables hydrosol-to-aerosol conversion preserving the size and morphology of particles, and also enables higher non-volatile residue tolerance than electrospray based aerosolization. Through LN-IMS measurements we show that the size distribution functions of narrowly distributed but similarly sized particles can be distinguished from one another, which is not possible with Nanoparticle Tracking Analysis in the sub-30 nm size range. Through comparison to electron microscopy measurements, we find that the size distribution functions inferred via LN-IMS measurements correspond to the particle sizes coated by surfactants, i.e. as they persist in colloidal suspensions. Finally, we show that the gas phase particle concentrations inferred from IMS size distribution functions are functions of only of the liquid phase particle concentration, and are independent of particle size, shape, and chemical composition. Therefore LN-IMS enables characterization of the size, yield, and polydispersity of sub-30 nm particles. PMID:26750519

  8. Miniature GC-Minicell Ion Mobility Spectrometer (IMS) for In Situ Measurements in Astrobiology Planetary Missions

    NASA Technical Reports Server (NTRS)

    Kojiro, Daniel R.; Stimac, Robert M.; Kaye, William J.; Holland, Paul M.; Takeuchi, Norishige

    2006-01-01

    Astrobiology flight experiments require highly sensitive instrumentation for in situ analysis of volatile chemical species and minerals present in the atmospheres and surfaces of planets, moons, and asteroids. The complex mixtures encountered place a heavy burden on the analytical instrumentation to detect and identify all species present. The use of land rovers and balloon aero-rovers place additional emphasis on miniaturization of the analytical instrumentation. In addition, smaller instruments, using tiny amounts of consumables, allow the use of more instrumentation and/or ionger mission life for stationary landers/laboratories. The miniCometary Ice and Dust Experiment (miniCIDEX), which combined Gas Chromatography (GC) with helium Ion Mobility Spectrometry (IMS), was capable of providing the wide range of analytical information required for Astrobiology missions. The IMS used here was based on the PCP model 111 IMS. A similar system, the Titan Ice and Dust Experiment (TIDE), was proposed as part of the Titan Orbiter Aerorover Mission (TOAM). Newer GC systems employing Micro Electro- Mechanical System (MEMS) based technology have greatly reduced both the size and resource requirements for space GCs. These smaller GCs, as well as the continuing miniaturization of Astrobiology analytical instruments in general, has highlighted the need for smaller, dry helium IMS systems. We describe here the development of a miniature, MEMS GC-IMS system (MEMS GC developed by Thorleaf Research Inc.), employing the MiniCell Ion Mobility Spectrometer (IMS), from Ion Applications Inc., developed through NASA's Astrobiology Science and Technology Instrument Development (ASTID) Program and NASA s Small Business Innovative Research (SBIR) Program.

  9. A Magellanic origin of the DES dwarfs

    NASA Astrophysics Data System (ADS)

    Jethwa, P.; Erkal, D.; Belokurov, V.

    2016-09-01

    We establish the connection between the Magellanic Clouds (MCs) and the dwarf galaxy candidates discovered in the Dark Energy Survey (DES) by building a dynamical model of the MC satellite populations, based on an extensive suite of tailor-made numerical simulations. Our model takes into account the response of the Galaxy to the MCs infall, the dynamical friction experienced by the MCs and the disruption of the MC satellites by their hosts. The simulation suite samples over the uncertainties in the MC's proper motions, the masses of the MW and the Clouds themselves, and allows for flexibility in the intrinsic volume density distribution of the MC satellites. As a result, we can accurately reproduce the DES satellites' observed positions and kinematics. Assuming that Milky Way (MW) dwarfs follow the distribution of sub-haloes in Λ cold dark matter, we further demonstrate that, of 14 observed satellites, the MW halo contributes fewer than 4(8) of these with 68(95) per cent confidence and that 7(12) DES dwarfs have probabilities greater than 0.7(0.5) of belonging to the Large Magellanic Cloud (LMC). Marginalizing over the entire suite, we constrain the number of Magellanic satellites in the range -7 < MV < -1 which exceed the DES surface brightness threshold at ˜70, and the mass of the LMC around 1011 M⊙. The data also strongly support a first-infall scenario for the LMC. Finally, we give predictions for the line-of-sight velocities and the proper motions of the satellites discovered in the vicinity of the LMC.

  10. Early Results from the DES SN Survey

    NASA Astrophysics Data System (ADS)

    Scolnic, Daniel; Dark Energy Survey

    2016-01-01

    The Dark Energy Survey Supernova program (DES SN) has already discovered over 1000 Type Ia supernovae with well-sampled multi-color light curves in the redshift range 0.1 < z < 1.2. I will present an overview of the survey and show recent advances in our detection, photometry, calibration and spectroscopic follow-up pipelines. I will go over initial results from photometric classification of our sample and discuss methods used to reach measurements of cosmological parameters.

  11. A Magellanic Origin of the DES Dwarfs

    NASA Astrophysics Data System (ADS)

    Jethwa, P.; Erkal, D.; Belokurov, V.

    2016-06-01

    We establish the connection between the Magellanic Clouds (MCs) and the dwarf galaxy candidates discovered in the Dark Energy Survey (DES) by building a dynamical model of the MC satellite populations, based on an extensive suite of tailor-made numerical simulations. Our model takes into account the response of the Galaxy to the MCs infall, the dynamical friction experienced by the MCs and the disruption of the MC satellites by their hosts. The simulation suite samples over the uncertainties in the MC's proper motions, the masses of the MW and the Clouds themselves and allows for flexibility in the intrinsic volume density distribution of the MC satellites. As a result, we can accurately reproduce the DES satellites' observed positions and kinematics. Assuming that Milky Way (MW) dwarfs follow the distribution of subhaloes in ΛCDM, we further demonstrate that, of 14 observed satellites, the MW halo contributes fewer than 4(8) of these with 68(95)% confidence and that 7(12) DES dwarfs have probabilities greater than 0.7(0.5) of belonging to the LMC. Marginalising over the entire suite, we constrain the number of Magellanic satellites in the range -7 < MV < -1 which exceed the DES surface brightness threshold at ˜70, and the mass of the LMC around 1011M⊙. The data also strongly support a first-infall scenario for the LMC. Finally, we give predictions for the line-of-sight velocities and the proper motions of the satellites discovered in the vicinity of the LMC.

  12. Snapshot Image Mapping Spectrometer (IMS) with high sampling density for hyperspectral microscopy

    PubMed Central

    Gao, Liang; Kester, Robert T.; Hagen, Nathan; Tkaczyk, Tomasz S.

    2010-01-01

    A snapshot Image Mapping Spectrometer (IMS) with high sampling density is developed for hyperspectral microscopy, measuring a datacube of dimensions 285 × 285 × 60 (x, y, λ). The spatial resolution is ~0.45 µm with a FOV of 100 × 100 µm2. The measured spectrum is from 450 nm to 650 nm and is sampled by 60 spectral channels with average sampling interval ~3.3 nm. The channel’s spectral resolution is ~8nm. The spectral imaging results demonstrate the potential of the IMS for real-time cellular fluorescence imaging. PMID:20639917

  13. Application of Ion Mobility Spectrometry (IMS) in forensic chemistry and toxicology with focus on biological matrices

    NASA Technical Reports Server (NTRS)

    Bernhard, Werner; Keller, Thomas; Regenscheit, Priska

    1995-01-01

    The IMS (Ion Mobility Spectroscopy) instrument 'Ionscan' takes advantage of the fact that trace quantities of illicit drugs are adsorbed on dust particles on clothes, in cars and on other items of evidence. The dust particles are collected on a membrane filter by a special attachment on a vacuum cleaner. The sample is then directly inserted into the spectrometer and can be analyzed immediately. We show casework applications of a forensic chemistry and toxicology laboratory. One new application of IMS in forensic chemistry is the detection of psilocybin in dried mushrooms without any further sample preparation.

  14. Power-efficient method for IM-DD optical transmission of multiple OFDM signals.

    PubMed

    Effenberger, Frank; Liu, Xiang

    2015-05-18

    We propose a power-efficient method for transmitting multiple frequency-division multiplexed (FDM) orthogonal frequency-division multiplexing (OFDM) signals in intensity-modulation direct-detection (IM-DD) optical systems. This method is based on quadratic soft clipping in combination with odd-only channel mapping. We show, both analytically and experimentally, that the proposed approach is capable of improving the power efficiency by about 3 dB as compared to conventional FDM OFDM signals under practical bias conditions, making it a viable solution in applications such as optical fiber-wireless integrated systems where both IM-DD optical transmission and OFDM signaling are important. PMID:26074605

  15. A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor

    PubMed Central

    Raskatov, Jevgenij A.; Puckett, James W.; Dervan, Peter B.

    2014-01-01

    In an effort to quantitate Py-Im polyamide concentrations in vivo, we synthesized the C-14 radioactively labeled compounds 1-3, and investigated their tumor localization in a subcutaneous xenograft model of prostate cancer (LNCaP). Tumor concentrations were compared with representative host tissues, and exhibited a certain degree of preferential localization to the xenograft. Compound accumulation upon repeated administration was measured. Py-Im polyamide 1 was found to accumulate in LNCaP tumors at concentrations similar to the IC50 value for this compound in cell culture experiments. PMID:24780272

  16. Profil anthropometrique des enfants scolarises tananariviens

    PubMed Central

    Razafimanantsoa, Fetralinjiva; Razafindramaro, Notahiana; Raherimandimby, Hasina; Robinson, Annick; RakotoAlson, Olivat; Rasamindrakotroka, Andry

    2013-01-01

    Les enfants tananariviens sont en état de malnutrition chronique. Notre objectif est d’évaluer l'indice de masse corporelle (IMC) pour estimer les enfants apparemment "sains". Une enquête et une mesure de la taille et du poids des enfants scolarisés tananariviens de 6 à 11 ans ont été réalisées. Après leur accord, la taille et l'indice de masse corporelle des 442 enfants tirés au hasard ont été ainsi obtenus. L'analyse de la moyenne de la taille a révélé une différence significative à 8 ans, une différence non évidente sur l'indice de masse corporelle. La comparaison avec les valeurs de référence (OMS 2006) a montré un retard statural de 34% avec une tendance globale à la hausse et un déficit pondéral égal à 5,5% selon le z score. Ainsi, au sein d'une population malnutrie, l'indice de masse corporelle pourrait être utilisé comme un des paramètres à considérer dans l’évaluation de l’état de santé pour classer ces enfants en bonne santé apparente. PMID:24711862

  17. Dermatomyosite et panniculite: place des immunoglobulines

    PubMed Central

    Abdelhafidh, Nadia Ben; Toujeni, Sana; Kefi, Asma; Bousetta, Najeh; Sayhi, Sameh; Gharsallah, Imen; Othmani, Salah

    2016-01-01

    La panniculite est une maladie inflammatoire du tissu adipeux sous-cutané rarement associée à la dermatomyosite. Elle peut survenir avant, après ou en même temps que l'atteinte musculaire. Dans la plupart des cas, l’évolution de la panniculite et des autres atteintes de la dermatomyosite est favorable sous traitement corticoïde et/ou immunosuppresseur. Nous rapportons le cas d'une patiente âgée de 48 ans ayant présenté des lésions de panniculite précédant de 2 mois les signes musculaires. L'atteinte cutanée était résistante au traitement corticoïde associés aux immunosuppresseurs ce qui a nécessité le recours au traitement par Immunoglobulines polyvalentes permettant ainsi une amélioration à la fois de l'atteinte cutanée et musculaire.

  18. Newtons Universum. Materialien zur Geschichte des Kraftbegriffes.

    NASA Astrophysics Data System (ADS)

    Mit einem Vorwort von E. Seibold und einer Einführung von W. Neuser. This book is a selection of 15 articles published in the journal "Spektrum der Wissenschaft". The original English versions of the papers were first published in "Scientific American". Contents: 1. Impetustheorie und Intuition in der Physik (M. McCloskey). 2. Mittelalterliche Ursprünge der industriellen Revolution (T. S. Reynolds). 3. Leonardo da Vincis Beiträge zur theoretischen Mechanik (V. Foley, W. Soedel). 4. Nikolaus Kopernikus und Tycho Brahe (O. Gingerich). 5. Keplers Entdeckung der ersten beiden Planetengesetze (C. Wilson). 6. Galileis Entdeckung des Fallgesetzes (S. Drake). 7. Galileis Beobachtung des Neptun (S. Drake, C. T. Kowal). 8. Galileo Galilei und der Schatten des Giordano Bruno (L. S. Lerner, E. A. Gosselin). 9. Der Fall Galilei (O. Gingerich). 10. Newtons Apfel und Galileis "Dialog" (S. Drake). 11. Newtons Gravitationsgesetz - aus Formeln wird eine Idee (I. B. Cohen). 12. Christopher Wren: Astronom und Architekt (H. Dorn, R. Mark). 13. Atomismus und Kräfte in der Geschichte (L. Holliday). 14. Ein Elitezirkel vor 200 Jahren: Die Lunar Society von Birmingham (L. Ritchie-Calder). 15. Sadi Carnot: Technik und Theorie der Dampfmaschine (S. S. Wilson).

  19. Choice of DES: is there a difference?

    PubMed Central

    Kaul, U; Bhatia, V

    2009-01-01

    Restenosis after percutaneous coronary interventions has been a major limitation of this otherwise very well-accepted method of coronary revascularisation. Coronary stents work by scaffolding the intimal flaps and preventing elastic recoil, which was a major problem after balloon angioplasty. The neointimal growth response to stenting contributes significantly to the restenotic process. Randomised studies comparing coronary artery bypass surgery with coronary stenting especially in multivessel disease clearly highlighted this problem. The problem has been greater in magnitude in special subgroups: diabetics, patients with small vessels (≤2.5 mm in diameter), long segments of disease (≥20 mm in length), etc. These limitations of Bare metal stents have been addressed by drug-eluting stents (DESs). Third-generation stents with bioabsorbable polymers like the Biolimus releasing Biomatrix stent have already become available in Europe and parts of Asia. A longer follow-up will prove their long-term safety vis-à-vis first-generation DES. The polymer-free stent with capability of using more than one drug, though very attractive, needs larger multicentric studies before gaining wider acceptance. The fully bioabsorbable stent is yet another promising concept. The feasibility has already been demonstrated, and finer refinements are under way. The future of newer DES thus is very promising, and most of the issues related to first-generation DES are at the threshold of being solved.

  20. Sécurité au-delà des mythes et des croyances

    ScienceCinema

    None

    2011-10-06

    Présentation orale en français, support visuel en français et en anglais. La pire des failles de sécurité est l'impression de sécurité. Le décalage entre la compréhension que l?on a des technologies utilisées, et leurs potentiels réels, ainsi que l'impact potentiellement négatif qu'elles peuvent avoir sur nos vies, n'est pas toujours compris, ou pris en compte par la plupart d'entre-nous. On se contente de nos perceptions pour ne pas avoir à se confronter à la réalité... Alors qu'en est-il vraiment ? En matière de sécurité qui de l'humain ou des technologies a le contrôle ?

  1. NMR characterization of a heterocomplex formed by distamycin and its analog 2-ImD with d(CGCAAGTTGGC):d(GCCAACTTGCG). Preference for the 1:1:1 2-ImD:Dst:DNA complex over the 2:1 2-ImD:DNA and the 2:1 Dst:DNA complexes

    SciTech Connect

    Geierstanger, B.H.; Dwyer, T.J.; Wemmer, D.E. ); Bathini, Y.; Lown, J.W. )

    1993-06-02

    The minor-groove binder distamycin (Dst), its pyrrole-imidazole-pyrrole analog, 2-imidazole-distamycin (2-ImD), and the oligonucleotide d(CGCAAGTTGGC):d(GCCAACTTGCG) were found to form a 1:1:1 2-ImD-Dst:DNA complex. As characterized by 2D NOE spectroscopy combined with molecular modeling, one 2-ImD and one Dst molecule bind simultaneously in a head-to-tail orientation contacting the minor groove of the central AAGTT:AACTT site. The 2-ImD ligand lies along the AAGTT strand with the imidazole nitrogen of the ligand specifically interacting with the guanine amino group. The distamycin ligand lies along the AACTT strand. The molecular structure of the 1:1:1 2-ImD:Dst:DNA complex is very similar to those of the complexes formed between two 2-ImD molecules (2:1 2-ImD:DNA complex) or two distamycin molecules (2:1 Dst:DNA complex) and the same oligonucleotide duplex. Competition titrations confirm that the 1:1:1 2-ImD:Dst:DNA complex forms preferentially over the 2:1 2-ImD:DNA complex, as well as over the newly discovered 2:1 Dst:DNA complex. These results indicate that (i) the hydrogen-bond-accepting imidazole nitrogen of the 2-ImD ligand in the 1:1:1 2-ImD:Dst:DNA complex is responsible for the strand-specific recognition of a GC base pair, (ii) the availability of a single hydrogen bond acceptor on the ligand molecule per guanine amino group enhanced both specificity and affinity of DNA binding, and (iii) different distamycin-like ligands can be combined in the 2:1 binding motif to expand the range of DNA sequences that can be specifically recognized through the minor groove. 18 refs., 7 figs., 4 tabs.

  2. Paternité des articles et intérêts concurrents : une analyse des recommandations aux auteurs des journaux traitant de pratique pharmaceutique

    PubMed Central

    Courbon, Ève; Tanguay, Cynthia; Lebel, Denis; Bussières, Jean-François

    2014-01-01

    RÉSUMÉ Contexte : La présence d’auteurs honorifiques et fantômes ainsi que les intérêts concurrents représentent des difficultés bien documentées, liées à la publication d’articles scientifiques. Il existe des lignes directrices encadrant la rédaction et la publication de manuscrits scientifiques, notamment celles de l’International Committee of Medical Journal Editors (ICMJE). Objectifs : L’objectif principal de cette étude descriptive et transversale visait à recenser les instructions portant sur la paternité des articles et les intérêts concurrents provenant des recommandations aux auteurs des journaux traitant de pratique pharmaceutique. L’objectif secondaire visait à déterminer des mesures correctrices pour une paternité des articles plus transparente. Méthode : La recherche a débuté par l’identification des journaux traitant de pratique pharmaceutique. La consultation des instructions aux auteurs des journaux a permis ensuite de recenser les recommandations destinées à éviter les problèmes de paternité des articles et d’intérêts concurrents. Finalement, les membres de l’équipe de recherche se sont consultés afin de définir des mesures correctrices possibles à l’intention des chercheurs. Résultats : Des 232 journaux traitant de pharmacie, 33 ont été définis comme traitant de pratique pharmaceutique. Un total de 24 (73 %) journaux mentionnaient suivre la politique de l’ICMJE, 14 (42 %) demandaient aux auteurs de remplir un formulaire de déclaration d’intérêts concurrents au moment de la soumission de l’article, 17 (52 %) présentaient une définition de la qualité d’auteur et 5 (15 %) demandaient de détailler les contributions de chaque auteur. Une grille de 40 critères a été élaborée pour définir l’attribution du statut d’auteur. Conclusion : Moins de la moitié des journaux demandait aux auteurs de transmettre un formulaire de déclaration des intérêts concurrents au moment de la

  3. Traitement des fractures des plateaux externes par vissage percutané assisté par arthroscopie

    PubMed Central

    Abouchane, Merouane; Belmoubarik, Amine; Benameur, Hamza; Haddoun, Ahmed Reda; Nechad, Mohammed

    2015-01-01

    Le but de notre étude est d'évaluer les résultats de fractures des plateaux tibiaux externes traitées par ostéosynthèse percutanée assistée par arthroscopie. Dix patients (8 hommes et 2 femmes) de 32 ans en moyenne ont subi cette intervention afin de réparer des fractures des plateaux tibiaux Schatzker I-III. Après avoir appliqué un garrot pneumatique, nous avons réduit et fixé la fracture au moyen de vis cannelées souschondrales. Lésions associées retrouvent deux lésions partielles du ménisque externe ont été retrouvé, traitées par résection partielle. Une orthèse de genou été de mise à but antalgique et protectrice pendant six semaines avec béquillage et interdiction de l'appui pour une durée de douze semaines avec reprise d'appui partiel au delà. La durée d'hospitalisation été d'une moyenne de cinq jours. La rééducation passive a été commence le lendemain de l'intervention et continuait dans chez un kinésithérapeute à la sortie du patient du service. Le suivi été à J7, J15, 1mois, 3mois, 6 mois puis tous les 6 mois. Neuf de nos patients ont été revu régulièrement sauf un perdu de vue. Le recul moyen de notre série été de 16 mois (10 et 24 mois). Le score de Lysholm a été utilisé pour évaluer les résultats cliniques chez nos neuf patients: excellent chez trois patients bons chez trois moyen chez un seul et mauvais chez deux patients. Tous nos neuf patients ont consolidé (figure 10 contrôle scopique d un article). Aucune gonarthrose n'a été note chez nos neuf patients due essentiellement au recul moyen faible de 16 mois. Le traitement des fractures des plateaux tibiaux externes assisté par arthroscopie produit des résultats satisfaisants et peut être accepté comme solution de rechange efficace au traitement des fractures des plateaux tibiaux causées par un choc de faible énergie. PMID:26587137

  4. Alcohol Use and Problem Drinking among Male Mexican and Central American Im/migrant Laborers: A Review of the Literature

    ERIC Educational Resources Information Center

    Worby, Paula A.; Organista, Kurt C.

    2007-01-01

    This review addresses a growing concern regarding alcohol use in adult male Latino im/migrant laborers in the United States. The review draws from alcohol studies focusing on "Hispanic" populations, and from health behavior studies of Latino im/migrant laborers, research that includes alcohol use. Specifically, this review addresses (a) alcohol…

  5. 40 CFR 52.2348 - National Highway Systems Designation Act Motor Vehicle Inspection and Maintenance (I/M) Programs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 4 2011-07-01 2011-07-01 false National Highway Systems Designation Act Motor Vehicle Inspection and Maintenance (I/M) Programs. 52.2348 Section 52.2348 Protection of... and Maintenance (I/M) Programs. (a) On March 15, 1996 the Governor of Utah submitted a revised...

  6. 40 CFR 52.2348 - National Highway Systems Designation Act Motor Vehicle Inspection and Maintenance (I/M) Programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 4 2010-07-01 2010-07-01 false National Highway Systems Designation Act Motor Vehicle Inspection and Maintenance (I/M) Programs. 52.2348 Section 52.2348 Protection of... and Maintenance (I/M) Programs. (a) On March 15, 1996 the Governor of Utah submitted a revised...

  7. Etude des phenomenes dynamiques ultrarapides et des caracteristiques impulsionnelles d'emission terahertz du supraconducteur YBCO

    NASA Astrophysics Data System (ADS)

    Savard, Stephane

    Les premieres etudes d'antennes a base de supraconducteurs a haute temperature critique emettant une impulsion electromagnetique dont le contenu en frequence se situe dans le domaine terahertz remontent a 1996. Une antenne supraconductrice est formee d'un micro-pont d'une couche mince supraconductrice sur lequel un courant continu est applique. Un faisceau laser dans le visible est focalise sur le micro-pont et place le supraconducteur dans un etat hors-equilibre ou des paires sont brisees. Grace a la relaxation des quasiparticules en surplus et eventuellement de la reformation des paires supraconductrices, nous pouvons etudier la nature de la supraconductivite. L'analyse de la cinetique temporelle du champ electromagnetique emis par une telle antenne terahertz supraconductrice s'est averee utile pour decrire qualitativement les caracteristiques de celle-ci en fonction des parametres d'operation tels que le courant applique, la temperature et la puissance d'excitation. La comprehension de l'etat hors-equilibre est la cle pour comprendre le fonctionnement des antennes terahertz supraconductrices a haute temperature critique. Dans le but de comprendre ultimement cet etat hors-equilibre, nous avions besoin d'une methode et d'un modele pour extraire de facon plus systematique les proprietes intrinseques du materiau qui compose l'antenne terahertz a partir des caracteristiques d'emission de celle-ci. Nous avons developpe une procedure pour calibrer le spectrometre dans le domaine temporel en utilisant des antennes terahertz de GaAs bombarde aux protons H+ comme emetteur et detecteur. Une fois le montage calibre, nous y avons insere une antenne emettrice dipolaire de YBa 2Cu3O7-delta . Un modele avec des fonctions exponentielles de montee et de descente du signal est utilise pour lisser le spectre du champ electromagnetique de l'antenne de YBa 2Cu3O7-delta, ce qui nous permet d'extraire les proprietes intrinseques de ce dernier. Pour confirmer la validite du modele

  8. Forms Development for the 1971-72 Tryout of IMS Version 3.

    ERIC Educational Resources Information Center

    Cooper, Pamela; Gibbs, Gordon L.

    For the 1971-72 tryout of IMS Version 3, special-purpose, optically scannable materials were developed and designed. Purpose, design considerations, and developmental stages are described for each form. Adapted formats for use with the Xerox 660 Scanner/Copier are explained. The forms are appended. (SK)

  9. A Suggested Approach for a Cost Analysis of Alternative IMS Configurations.

    ERIC Educational Resources Information Center

    Besel, Ronald

    An approach to a cost analysis of pilot, prototype, model and operational versions of the Southwest Regional Laboratory's (SWRL) Instructional Management System (IMS) is described. Five classes of systems (conceptual, pilot, prototype, model and operational) are defined, and a system development process relating classes of systems in presented.…

  10. School Evaluation Using the CASE-IMS Model and Improvement Process.

    ERIC Educational Resources Information Center

    Keefe, James

    1994-01-01

    The Comprehensive Assessment of School Environments Information Management System (CASE-IMS) is described as a model and as a school improvement process that can provide schools with a framework and research-based tools for achieving a vision. Development of the model, its 34 variables, and the computerized information management system are…

  11. Investigating Perfect Timesharing: The Relationship between IM-Compatible Tasks and Dual-Task Performance

    ERIC Educational Resources Information Center

    Halvorson, Kimberly M.; Ebner, Herschel; Hazeltine, Eliot

    2013-01-01

    Why are dual-task costs reduced with ideomotor (IM) compatible tasks (Greenwald & Shulman, 1973; Lien, Proctor & Allen, 2002)? In the present experiments, we first examine three different measures of single-task performance (pure single-task blocks, mixed blocks, and long stimulus onset asynchrony [SOA] trials in dual-task blocks) and two measures…

  12. 40 CFR 51.351 - Enhanced I/M performance standard.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 2 2013-07-01 2013-07-01 false Enhanced I/M performance standard. 51.351 Section 51.351 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Inspection/Maintenance Program Requirements § 51.351 Enhanced...

  13. 40 CFR 51.351 - Enhanced I/M performance standard.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 2 2012-07-01 2012-07-01 false Enhanced I/M performance standard. 51.351 Section 51.351 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Inspection/Maintenance Program Requirements § 51.351 Enhanced...

  14. The Aries Program with emphasis on the International Magnetospherics Studies /IMS/-Porcupine Project

    NASA Technical Reports Server (NTRS)

    Honecker, H. J.

    1976-01-01

    This paper will discuss the present state of the development of the Aries Sounding Rocket System with particular emphasis on the configuration and subsystems required to support the IMS Program. A brief history of the development program will be presented. The results of the first five flights, three successes and two failures, will be presented and the observed performance compared to theoretical performance.

  15. 40 CFR 51.352 - Basic I/M performance standard.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... both in operation and for SIP approval. (1) Network type. Centralized testing. (2) Start date. For areas with existing I/M programs, 1983. For areas newly subject, 1994. (3) Test frequency. Annual... specified in 40 CFR part 85, subpart W. (8) Emission control device inspections. None. (9) Stringency. A...

  16. The Role of Ki 'Im in Orchestrating Contrastive Focus in Biblical Hebrew

    ERIC Educational Resources Information Center

    Park, Grace Jeongyeon

    2011-01-01

    The so-called compound use of ki 'im has been interpreted mainly either with exceptive ("except" or "unless") or adversative meaning ("but" or "rather"), although it has sometimes also been interpreted in other ways such as "only" or "surely". These various meanings have been applied…

  17. Combining IM and Vendor-Based Chat: A Report from the Frontlines of an Integrated Service

    ERIC Educational Resources Information Center

    Ward, David; Kern, M. Kathleen

    2006-01-01

    Driven by studies showing that Millennials (ages 18-24) have adopted IM (instant messaging) as a standard communications medium, many libraries are reaching out to their own patrons in this way. At the same time, some of these libraries have invested thousands of dollars in vendor-based chat reference solutions that provide duplicate…

  18. imDEV: a graphical user interface to R multivariate analysis tools in Microsoft Excel

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Interactive modules for data exploration and visualization (imDEV) is a Microsoft Excel spreadsheet embedded application providing an integrated environment for the analysis of omics data sets with a user-friendly interface. Individual modules were designed to provide toolsets to enable interactive ...

  19. I'm a Scientist, Get Me out of Here! (Australia)

    ERIC Educational Resources Information Center

    Teaching Science, 2012

    2012-01-01

    The May event of I'm a Scientist, Get Me Out of Here! harnessed fifteen scientists in three general zones, engaging almost 800 students from twenty two schools across the country, generating 624 answered questions, 406 comments and fifty three live-chat sessions. (Contains 4 photos.)

  20. Engineering and development projects for the sustainment and enhancement of the IMS infrasound network

    NASA Astrophysics Data System (ADS)

    Marty, J.; Martysevich, P.; Kramer, A.; Haralabus, G.

    2012-04-01

    The Provisional Technical Secretariat (PTS) of the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) has a continuous interest in enhancing its capability in infrasound source localization and characterization. This capability is based on the processing of data recorded by the infrasound network of the International Monitoring System (IMS). This infrasound network consists of sixty stations, among which forty-five are already certified and continuously transmit data to the International Data Center (IDC) in Vienna, Austria. Each infrasound station is composed of an array of infrasound sensors capable of measuring micro-pressure changes produced at ground level by infrasonic waves. It is the responsibility of the Engineering and Development Section of the IMS Division to ensure the highest quality for IMS infrasound data. This includes the design of robust and reliable infrasound stations, the use of accurate and calibrated infrasound measuring chains, the installation of efficient wind noise reduction systems and the implementation of quality-control tools. The purpose of this paper is to present ongoing PTS infrasound engineering and development projects related to the testing and validation of wind noise reduction system models, the implementation of infrasound data QC tools, the definition of guidelines for the design of IMS power supply systems and the development of a portable infrasound calibrator and of field kits for site survey and certification.

  1. A novel delta-endotoxin gene cryIM from Bacillus thuringiensis ssp. wuhanensis.

    PubMed

    Shevelev, A B; Kogan YaN; Bushueva, A M; Voronina, E J; Rebrikov, D V; Novikova, S I; Chestukhina, G G; Kuvshinov, V; Pehu, E; Stepanov, V M

    1997-03-10

    A new cryI-related sequence designated cryIM was cloned using an immunoscreening technique from ssp. wuhanensis of Bacillus thuringiensis (BT), previously reported to produce multiple Cry proteins [Chestukhina et al. (1994) Can. J. Microbiol. 240, 1026-1034]. Analysis of the cryIM nucleotide sequence revealed an ORF, BTII-type promoter-like sequence, peculiar for such genes, a translation initiation element and a putative transcription terminator. Nevertheless, its product was not previously found in the crystals of the host strain [Chestukhina et al. (1994) Can. J. Microbiol. 240, 1026-1034] which shows its weak or absent natural expression. The amino acid sequence of 1151 residues encoded by the continuous reading frame of cryIM is not identical but is essentially similar to the other delta-endotoxins of the CryI class. An IS231-like sequence was found 400 bp downstream of the cryIM stop codon and a fragment of the cryIAb gene was located 3 kb upstream of its initiator codon in the same orientation. Artificial expression of the cloned gene in E. coli under the control of the lacZ promoter allowed us to obtain its hypothetical protein product. PMID:9119053

  2. I'm Sorry "About That": Apologies, Indexicals, and (Unnamed) Offenses

    ERIC Educational Resources Information Center

    Margutti, Piera; Traverso, Véronique; Pugliese, Rosa

    2016-01-01

    We investigate an apology format, "I'm sorry about it/that," where indexical terms (pronouns) refer to the offense rather than naming it. We identified two subsets in our collection of indexical apologies. In one, indexicals are subsequent either to the offense formulation or to an apology-relevant event; in the second, indexicals are…

  3. Out-Life Characteristics of IM7/977-3 Composites

    NASA Technical Reports Server (NTRS)

    Miller, Sandi G.; Sutter, James K.; Hou, Tan-Hung; Scheiman, Daniel A.; Martin, Richard E.; Maryanski, Michael; Schlea, Michelle; Gardner, John M.; Schiferl, Zack R.

    2010-01-01

    The capability to manufacture large structures leads to weight savings and reduced risk relative to joining smaller components. However, manufacture of increasingly large composite components is pushing the out-time limits of epoxy/ carbon fiber prepreg. IM7/977-3 is an autoclave processable prepreg material, commonly used in aerospace structures. The out-time limit is reported as 30 days by the manufacturer. The purpose of this work was to evaluate the material processability and composite properties of 977-3 resin and IM7/977-3 prepreg that had been aged at room temperature for up to 60 days. The effects of room temperature aging on the thermal and visco-elastic properties of the materials were investigated. Neat resin was evaluated by differential scanning calorimetry to characterize thermal properties and change in activation energy of cure. Neat resin was also evaluated by rheometry to characterize its processability in composite fabrication. IM7/977-3 prepreg was evaluated by dynamic mechanical analysis to characterize the curing behavior. Prepreg tack was also evaluated over 60 days. The overall test results suggested that IM7/977-3 was a robust material that offered quality laminates throughout this aging process when processed by autoclave.

  4. W8...b4 IM, how did u rite??! Digital Writing in the Composition Classroom

    ERIC Educational Resources Information Center

    Partridge, Bryan

    2011-01-01

    From word processing computers, to mobile telephones, to the advent of the Internet, and finally to online communication venues like Instant Messenger (IM), the past four decades have brought an increasing prevalence of technology into our culture that is altering the English language. While decried by parents and lamented by teachers, these…

  5. "I'm Sorry + Naming the Offense": A Format for Apologizing

    ERIC Educational Resources Information Center

    Cirillo, Letizia; Colón de Carvajal, Isabel; Ticca, Anna Claudia

    2016-01-01

    The present article focuses on "I'm sorry + naming the offense"-formatted apologies occurring in phone calls in English. Apologies of this kind "emerge" and are oriented to as relevant actions when addressing an apologizable that is not the main business in ongoing talk. The sequential analysis of apologies and responses to…

  6. The (Im)possibility of Poststructuralist Ethnography--Researching Identities in Borrowed Spaces

    ERIC Educational Resources Information Center

    Tsolidis, Georgina

    2008-01-01

    The notion of site is critical to ethnography and provides a sense of spatial stability--somewhere the researcher enters in order to research what is contained within. Using contemporary understandings of space, the author reflects on two studies to explore the (im)possibility of poststructuralist ethnography. The first study was undertaken in a…

  7. 40 CFR 51.352 - Basic I/M performance standard.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... specified in 40 CFR part 85, subpart W. (8) Emission control device inspections. None. (9) Stringency. A 20... vehicles. (7) Emission standards. Those specified in 40 CFR part 85, subpart W. (8) Emission control device... date. Basic I/M program areas subject to the provisions of this paragraph (e) shall be shown to...

  8. "Chemie im Kontext": A Symbiotic Implementation of a Context-Based Teaching and Learning Approach

    ERIC Educational Resources Information Center

    Parchmann, Ilka; Grasel, Cornelia; Baer, Anja; Nentwig, Peter; Demuth, Reinhard; Ralle, Bernd

    2006-01-01

    "Chemie im Kontext" (ChiK) is a project that aims at the improvement of chemistry teaching at secondary school in Germany. Based on a framework that was derived from theories and empirical data on the teaching and learning of science, science education researchers and teachers work together on learning communities to transform this framework into…

  9. 40 CFR 51.352 - Basic I/M performance standard.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... specified in 40 CFR part 85, subpart W. (8) Emission control device inspections. None. (9) Stringency. A 20... vehicles. (7) Emission standards. Those specified in 40 CFR part 85, subpart W. (8) Emission control device... 40 Protection of Environment 2 2012-07-01 2012-07-01 false Basic I/M performance standard....

  10. A Service Oriented Web Application for Learner Knowledge Representation, Management and Sharing Conforming to IMS LIP

    ERIC Educational Resources Information Center

    Lazarinis, Fotis

    2014-01-01

    iLM is a Web based application for representation, management and sharing of IMS LIP conformant user profiles. The tool is developed using a service oriented architecture with emphasis on the easy data sharing. Data elicitation from user profiles is based on the utilization of XQuery scripts and sharing with other applications is achieved through…

  11. Knowledge Base for Automatic Generation of Online IMS LD Compliant Course Structures

    ERIC Educational Resources Information Center

    Pacurar, Ecaterina Giacomini; Trigano, Philippe; Alupoaie, Sorin

    2006-01-01

    Our article presents a pedagogical scenarios-based web application that allows the automatic generation and development of pedagogical websites. These pedagogical scenarios are represented in the IMS Learning Design standard. Our application is a web portal helping teachers to dynamically generate web course structures, to edit pedagogical content…

  12. InstanceCollage: A Tool for the Particularization of Collaborative IMS-LD Scripts

    ERIC Educational Resources Information Center

    Villasclaras-Fernandez, Eloy D.; Hernandez-Gonzalo, Julio A.; Hernandez-Leo, Davinia; Asensio-Perez, Juan I.; Dimitriadis, Yannis; Martinez-Mones, Alejandra

    2009-01-01

    Current research work in e-learning and more specifically in the field of CSCL (Computer Supported Collaborative Learning) deals with design of collaborative activities, according to computer-interpretable specifications, such as IMS Learning Design, and their posterior enactment using LMSs (Learning Management Systems). A script that describes…

  13. The (Im)Materiality of Literacy: The Significance of Subjectivity to New Literacies Research

    ERIC Educational Resources Information Center

    Burnett, Cathy; Merchant, Guy; Pahl, Kate; Rowsell, Jennifer

    2014-01-01

    This article deconstructs the online and offline experience to show its complexities and idiosyncratic nature. It proposes a theoretical framework designed to conceptualise aspects of meaning-making across on- and offline contexts. In arguing for the "(im)materiality" of literacy, it makes four propositions which highlight the complex…

  14. Using the Personal Competence Manager as a Complementary Approach to IMS Learning Design Authoring

    ERIC Educational Resources Information Center

    Vogten, Hubert; Koper, Rob; Martens, Harrie; van Bruggen, Jan

    2008-01-01

    In this article TENCompetence will be presented as a framework for lifelong competence development. More specifically, the relationship between the TENCompetence framework and the IMS Learning Design (LD) specification is explored. LD authoring has proven to be challenging and the toolset currently available is targeting expert users mostly…

  15. Generic Service Integration in Adaptive Learning Experiences Using IMS Learning Design

    ERIC Educational Resources Information Center

    de-la-Fuente-Valentin, Luis; Pardo, Abelardo; Kloos, Carlos Delgado

    2011-01-01

    IMS Learning Design is a specification to capture the orchestration taking place in a learning scenario. This paper presents an extension called Generic Service Integration. This paradigm allows a bidirectional communication between the course engine in charge of the orchestration and conventional Web 2.0 tools. This communication allows the…

  16. Les neuropeptides gastro-intestinaux cibles des effets des rayonnements ionisants : altérations fonctionnelles

    NASA Astrophysics Data System (ADS)

    Linard, C.; Esposito, V.; Wysocki, J.; Griffiths, N. M.

    1998-04-01

    The symptoms associated with exposure to ionizing radiation are nausea, vomiting, diarrhoea. The response of the gut is complex involving modifications of motility and fluid and electrolyte transport. Gastrointestinal regulatory peptides have an important role in these functions. This study showed that radiation-induced tissue variations of neuropeptides have some repercussions on intestinal biological activity of these peptides soon after irradiation. In addition such modifications are also seen a few years after irradiation. Les symptômes associés à l'exposition aux rayonnements ionisants sont des nausées, vomissements et diarrhées. La réponse du système digestif est complexe, impliquant des modifications de la motilité et du transport d'eau et d'électrolytes. les neuropeptides gastro-intestinaux ont un rôle important dans ces fonctions. Cette étude montre que les variations tissulaires de ces neuropeptides induites par l'irradiation ont des répercussions sur l'activité biologique intestinale pour des temps précoces mais que ces perturbations sont encore visibles quelques années après l'irradiation.

  17. Vers des boites quantiques a base de graphene

    NASA Astrophysics Data System (ADS)

    Branchaud, Simon

    Le graphene est un materiau a base de carbone qui est etudie largement depuis 2004. De tres nombreux articles ont ete publies tant sur les proprietes electroniques, qu'optiques ou mecaniques de ce materiel. Cet ouvrage porte sur l'etude des fluctuations de conductance dans le graphene, et sur la fabrication et la caracterisation de nanostructures gravees dans des feuilles de ce cristal 2D. Des mesures de magnetoresistance a basse temperature ont ete faites pres du point de neutralite de charge (PNC) ainsi qu'a haute densite electronique. On trouve deux origines aux fluctuations de conductance pres du PNC, soit des oscillations mesoscopiques provenant de l'interference quantique, et des fluctuations dites Hall quantique apparaissant a plus haut champ (>0.5T), semblant suivre les facteurs de remplissage associes aux monocouches de graphene. Ces dernieres fluctuations sont attribuees a la charge d'etats localises, et revelent un precurseur a l'effet Hall quantique, qui lui, ne se manifeste pas avant 2T. On arrive a extraire les parametres caracterisant l'echantillon a partir de ces donnees. A la fin de cet ouvrage, on effectue des mesures de transport dans des constrictions et ilots de graphene, ou des boites quantiques sont formees. A partir de ces mesures, on extrait les parametres importants de ces boites quantiques, comme leur taille et leur energie de charge.

  18. Peste des Petits Ruminants Virus in Heilongjiang Province, China, 2014

    PubMed Central

    Wang, Miao; Wang, Shida; Liu, Zaisi; Shen, Nan; Si, Wei; Sun, Gang; Drewe, Julian A.; Cai, Xuehui

    2015-01-01

    During March 25–May 5, 2014, we investigated 11 outbreaks of peste des petits ruminants in Heilongjiang Province, China. We found that the most likely source of the outbreaks was animals from livestock markets in Shandong. Peste des petits ruminants viruses belonging to lineages II and IV were detected in sick animals. PMID:25811935

  19. Altération des sulfures des granulats dans les chaussées

    NASA Astrophysics Data System (ADS)

    Jigorel, A.; Jauberthie, R.

    2002-07-01

    Sulfides present in hornsfeld aggregates, used in light pavanent construction in contact with humid air alter rapidly. Crystallisation of sulfates at the interface of bitumastic material and sub-base creates serious problems (intumescence and crazing) that can lead to a total reconstruction of the project (roads, sidewalks, sports areas, etc). The sulfides in the aggregates and the sulfates produced due to alteration are studied by SEM and XRD. The results show that the intensity of this phenomenon is linked to the nature and the crystallinity of the sulfides. The evolution of the sulfates formed during this alteration process is slow and complex. In new pavements (3 years) the sulfates have a pulverised appearance and consist mostly of epsomite, associated with pickeringite and halotrichite. In older pavements (20 years) the sulfates form a fibrous concretion consisting of pickeringite and small quantities of halotrichite. Les sulfures présents dans les granulats élaborés à partir de cornéen nes s'altèrent rapidement dans les chaussées légères en présence d'air humide. La cristallisation des sulfates à l'interface enrobé-couche de fondation crée des désordres si importants (intumescences, faiençage) qu'il est bien souvent nécessaire d'assurer la réfection totale des ouvrages (routes, trottoirs, plateaux sportifs...). Les sulfures des granulats et les sulfates issus du processus d'altération ont été étudiés par diffractométrie X et examen su Microscope Electronique à Balayage équipé de microanalyse X. Les résultats montrent que !intensité des désordres est liée à la nature et à la cristallinité des sulfures. Les sulfates formés évoluent su cours du processus d'altération qui est long et complexe. Dans les chaussées récentes (3 ans) ils ont un aspect pulvérulent et sont constitués d'epsomite dominante associée à de la pickeringite et à de l'halotrichite. Dans les chaussées plus anciennes (20 ans) ils forment des concr

  20. Detection capability of the IMS seismic network based on ambient seismic noise measurements

    NASA Astrophysics Data System (ADS)

    Gaebler, Peter J.; Ceranna, Lars

    2016-04-01

    All nuclear explosions - on the Earth's surface, underground, underwater or in the atmosphere - are banned by the Comprehensive Nuclear-Test-Ban Treaty (CTBT). As part of this treaty, a verification regime was put into place to detect, locate and characterize nuclear explosion testings at any time, by anyone and everywhere on the Earth. The International Monitoring System (IMS) plays a key role in the verification regime of the CTBT. Out of the different monitoring techniques used in the IMS, the seismic waveform approach is the most effective technology for monitoring nuclear underground testing and to identify and characterize potential nuclear events. This study introduces a method of seismic threshold monitoring to assess an upper magnitude limit of a potential seismic event in a certain given geographical region. The method is based on ambient seismic background noise measurements at the individual IMS seismic stations as well as on global distance correction terms for body wave magnitudes, which are calculated using the seismic reflectivity method. From our investigations we conclude that a global detection threshold of around mb 4.0 can be achieved using only stations from the primary seismic network, a clear latitudinal dependence for the detection threshold can be observed between northern and southern hemisphere. Including the seismic stations being part of the auxiliary seismic IMS network results in a slight improvement of global detection capability. However, including wave arrivals from distances greater than 120 degrees, mainly PKP-wave arrivals, leads to a significant improvement in average global detection capability. In special this leads to an improvement of the detection threshold on the southern hemisphere. We further investigate the dependence of the detection capability on spatial (latitude and longitude) and temporal (time) parameters, as well as on parameters such as source type and percentage of operational IMS stations.

  1. VLBI FOR GRAVITY PROBE B. V. PROPER MOTION AND PARALLAX OF THE GUIDE STAR, IM PEGASI

    SciTech Connect

    Ratner, M. I.; Lebach, D. E.; Shapiro, I. I.; Bartel, N.; Bietenholz, M. F.; Ransom, R. R.; Lestrade, J.-F.

    2012-07-01

    We present the principal astrometric results of the very long baseline interferometry (VLBI) program undertaken in support of the Gravity Probe B (GP-B) relativity mission. VLBI observations of the GP-B guide star, the RS CVn binary IM Pegasi (HR 8703), yielded positions at 35 epochs between 1997 and 2005. We discuss the statistical assumptions behind these results and our methods for estimating the systematic errors. We find the proper motion of IM Peg in an extragalactic reference frame closely related to the International Celestial Reference Frame 2 (ICRF2) to be -20.83 {+-} 0.03 {+-} 0.09 mas yr{sup -1} in right ascension and -27.27 {+-} 0.03 {+-} 0.09 mas yr{sup -1} in declination. For each component, the first uncertainty is the statistical standard error and the second is the total standard error (SE) including plausible systematic errors. We also obtain a parallax of 10.37 {+-} 0.07 mas (distance: 96.4 {+-} 0.7 pc), for which there is no evidence of any significant contribution of systematic error. Our parameter estimates for the {approx}25 day period orbital motion of the stellar radio emission have SEs corresponding to {approx}0.10 mas on the sky in each coordinate. The total SE of our estimate of IM Peg's proper motion is {approx}30% smaller than the accuracy goal set by the GP-B project before launch: 0.14 mas yr{sup -1} for each coordinate of IM Peg's proper motion. Our results ensure that the uncertainty in IM Peg's proper motion makes only a very small contribution to the uncertainty of the GP-B relativity tests.

  2. An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies

    SciTech Connect

    Baker, Erin Shammel; Livesay, Eric A.; Orton, Daniel J.; Moore, Ronald J.; Danielson, William F.; Prior, David C.; Ibrahim, Yehia M.; Lamarche, Brian L.; Mayampurath, Anoop M.; Schepmoes, Athena A.; Hopkins, Derek F.; Tang, Keqi; Smith, Richard D.; Belov, Mikhail E.

    2010-02-05

    A high-throughput approach and platform using 15 minute reversed-phase capillary liquid chromatography (RPLC) separations in conjunction with ion mobility spectrometry-mass spectrometry (IMS-MS) measurements was evaluated for the rapid analysis of complex proteomics samples. To test the separation quality of the short LC gradient, a sample was prepared by spiking twenty reference peptides at varying concentrations from 1 ng/mL to 10 µg/mL into a tryptic digest of mouse blood plasma and analyzed with both a LC-Linear Ion Trap Fourier Transform (FT) MS and LC-IMS-TOF MS. The LC-FT MS detected thirteen out of the twenty spiked peptides that had concentrations ≥100 ng/mL. In contrast, the drift time selected mass spectra from the LC-IMS-TOF MS analyses yielded identifications for nineteen of the twenty peptides with all spiking level present. The greater dynamic range of the LC-IMS-TOF MS system could be attributed to two factors. First, the LC-IMS-TOF MS system enabled drift time separation of the low concentration spiked peptides from the high concentration mouse peptide matrix components, reducing signal interference and background, and allowing species to be resolved that would otherwise be obscured by other components. Second, the automatic gain control (AGC) in the linear ion trap of the hybrid FT MS instrument limits the number of ions that are accumulated to reduce space charge effects, but in turn limits the achievable dynamic range compared to the TOF detector.

  3. Automation of PCXMC and ImPACT for NASA Astronaut Medical Imaging Dose and Risk Tracking

    NASA Technical Reports Server (NTRS)

    Bahadori, Amir; Picco, Charles; Flores-McLaughlin, John; Shavers, Mark; Semones, Edward

    2011-01-01

    To automate astronaut organ and effective dose calculations from occupational X-ray and computed tomography (CT) examinations incorporating PCXMC and ImPACT tools and to estimate the associated lifetime cancer risk per the National Council on Radiation Protection & Measurements (NCRP) using MATLAB(R). Methods: NASA follows guidance from the NCRP on its operational radiation safety program for astronauts. NCRP Report 142 recommends that astronauts be informed of the cancer risks from reported exposures to ionizing radiation from medical imaging. MATLAB(R) code was written to retrieve exam parameters for medical imaging procedures from a NASA database, calculate associated dose and risk, and return results to the database, using the Microsoft .NET Framework. This code interfaces with the PCXMC executable and emulates the ImPACT Excel spreadsheet to calculate organ doses from X-rays and CTs, respectively, eliminating the need to utilize the PCXMC graphical user interface (except for a few special cases) and the ImPACT spreadsheet. Results: Using MATLAB(R) code to interface with PCXMC and replicate ImPACT dose calculation allowed for rapid evaluation of multiple medical imaging exams. The user inputs the exam parameter data into the database and runs the code. Based on the imaging modality and input parameters, the organ doses are calculated. Output files are created for record, and organ doses, effective dose, and cancer risks associated with each exam are written to the database. Annual and post-flight exposure reports, which are used by the flight surgeon to brief the astronaut, are generated from the database. Conclusions: Automating PCXMC and ImPACT for evaluation of NASA astronaut medical imaging radiation procedures allowed for a traceable and rapid method for tracking projected cancer risks associated with over 12,000 exposures. This code will be used to evaluate future medical radiation exposures, and can easily be modified to accommodate changes to the risk

  4. Electrocardiogram-gated coronary CT angiography dose estimates using ImPACT.

    PubMed

    Kobayashi, Masanao; Asada, Yasuki; Matsubara, Kosuke; Suzuki, Shouichi; Koshida, Kichiro; Matsunaga, Yuta; Haba, Tomonobu; Kawaguchi, Ai; Toyama, Hiroshi; Kato, Ryouichi

    2016-01-01

    The primary study objective was to assess radiation doses using a modified form of the Imaging Performance Assessment of Computed Tomography (CT) scanner (ImPACT) patient dosimetry for cardiac applications on an Aquilion ONE ViSION Edition scanner, including the Ca score, target computed tomography angiography (CTA), prospective CTA, continuous CTA/cardiac function analysis (CFA), and CTA/CFA modulation. Accordingly, we clarified the CT dose index (CTDI) to determine the relationship between heart rate (HR) and X-ray exposure. As a secondary objective, we compared radiation doses using modified ImPACT, a whole-body dosimetry phantom study, and the k-factor method to verify the validity of the dose results obtained with modified ImPACT. The effective dose determined for the reference person (4.66 mSv at 60 beats per minute (bpm) and 33.43 mSv at 90bpm) were approximately 10% less than those determined for the phantom study (5.28 mSv and 36.68 mSv). The effective doses according to the k-factor (0.014 mSv•mGy-1•cm-1; 2.57 mSv and 17.10 mSv) were significantly lower than those obtained with the other two methods. In the present study, we have shown that ImPACT, when modified for cardiac applications, can assess both absorbed and effective doses. The results of our dose comparison indicate that modified ImPACT dose assessment is a promising and practical method for evaluating coronary CTA. PMID:27455500

  5. Fissuration en relaxation des aciers inoxydables austénitiques au voisinage des soudures

    NASA Astrophysics Data System (ADS)

    Auzoux, Q.; Allais, L.; Gourgues, A. F.; Pineau, A.

    2003-03-01

    Des fissures intergranulaires peuvent se développer au voisinage des soudures des aciers inoxydables austénitiques lorsqu'ils sont réchauffés dans le domaine de température compris entre 500^{circ}C et 700^{circ}C. A ces températures, les contraintes résiduelles post-soudage se relaxent par déformation viscoplastique. Il peut arriver que ces zones proches de la soudure soient tellement fragiles, qu'elles ne puissent accommoder cette faible déformation. Afin de préciser quelles peuvent être les modifications microstructurales qui conduisent à une telle fragilisation, on a examiné les microstructures de ces zones et révélé ainsi un écrouissage résiduel, responsable d'une forte élévation de la dureté. On a pu reproduire par hypertrempe puis laminage entre 400^{circ}C et 600^{circ}C une microstructure similaire. Des essais mécaniques (traction, fluage, relaxation, sur éprouvettes lisses et pré-fissurées) ont été réalisés à 550^{circ}C et à 600^{circ}C sur ces zones affectées simulées et sur un état de référence hypertrempé. Ils ont montré que l'écrouissage diminuait la ductilité dans le domaine de rupture intergranulaire, sans modifier qualitativement le mécanisme d'endommagement. Pendant la pré-déformation les incompatibilités de déformation entre grains conduiraient à l'existence de contraintes locales élevées qui favoriseraient la germination des cavités intergranulaires.

  6. Hans Bethe : Des etoiles a la bombe

    NASA Astrophysics Data System (ADS)

    Bonnet-Bidaud, J. M.

    1996-06-01

    Il comprit le premier comment brillent les etoiles. Il fut aussi de cette poignee de scientifiques qui, dans le secret de Los Alamos, mirent au point la tristement celebre bombe atomique. Hans Bethe est l'un des derniers geants qui auront marque la physique de ce siecle d'une empreinte indelebile. C'est dans le bureau 01 du prestigieux laboratoire Kellog de l'institut Caltech qu'il a bien voulu retracer pour nous son impressionnante carriere, et revenir sur les motivations qui ont guide ses pas.

  7. Le traitement familial des enfants et des adolescents anorexiques : Des lignes directrices pour le médecin communautaire

    PubMed Central

    Findlay, S; Pinzon, J; Taddeo, D; Katzman, DK

    2010-01-01

    L’anorexie mentale (AM) est une maladie grave qui met la vie en danger et qui fait généralement son apparition pendant l’adolescence. Les données probantes au sujet du traitement optimal de l’AM chez les enfants et les adolescents sont en croissance, mais il reste beaucoup à apprendre. Même si les démarches thérapeutiques actuelles varient au Canada et ailleurs, les données jusqu’à présent indiquent que le traitement familial (TF) est le plus efficace pour les enfants et les adolescents anorexiques. Un élément essentiel du modèle de TF, c’est que les parents sont investis de la responsabilité de rétablir la santé physique de leur enfant et de s’assurer de la reprise complète de son poids. Le médecin qui comprend les principes fondamentaux et la philosophie du TF peut mettre en place les éléments de cette intervention fondée sur des faits probants auprès des jeunes patients anorexiques et de leur famille.

  8. LC-IMS-MS Feature Finder. Detecting Multidimensional Liquid Chromatography, Ion Mobility, and Mass Spectrometry Features in Complex Datasets

    SciTech Connect

    Crowell, Kevin L.; Slysz, Gordon W.; Baker, Erin Shammel; Lamarche, Brian L.; Monroe, Matthew E.; Ibrahim, Yehia M.; Payne, Samuel H.; Anderson, Gordon A.; Smith, Richard D.

    2013-09-05

    We introduce a command line software application LC-IMS-MS Feature Finder that searches for molecular ion signatures in multidimensional liquid chromatography-ion mobility spectrometry-mass spectrometry (LC-IMS-MS) data by clustering deisotoped peaks with similar monoisotopic mass, charge state, LC elution time, and ion mobility drift time values. The software application includes an algorithm for detecting and quantifying co-eluting chemical species, including species that exist in multiple conformations that may have been separated in the IMS dimension.

  9. Automatische Segmentierung der Gewebegrenzen eines schlagenden embryonalen Hühnerherzens im 2D-Videobild

    NASA Astrophysics Data System (ADS)

    Thommes, Jan; Yelbuz, Talât Mesud

    Eine Klimakammer ermöglicht es, die Herzentwicklung bei Hühnerembryonen in einer schalenlosen Kultur über einen Zeitraum von etwa 50 Stunden visuell zu beobachten. Eine Hochgeschwindigkeits-Mikroskopkamera liefert eine Aufsicht auf das schlagende embryonale Herz. Da die für eine Analyse der Herzfunktion notwendige Segmentierung der Myokardgrenzen und des blutgefüllte Cavums manuell sehr zeitaufwändig ist, wird ein Ansatz zur kontinuierlichen, automatischen Segmentierung des schlagenden embryonalen Herzens mit Active Appearance Modellen präsentiert.

  10. UTILIZATION OF ImPACT TESTING TO MEASURE INJURY RISK IN ALPINE SKI AND SNOWBOARD ATHLETES

    PubMed Central

    Huntimer, Brittney; Kernozek, Thomas; Cole, John

    2016-01-01

    ABSTRACT Background While studies that have examined the prevalence of musculoskeletal injuries in alpine skiing and snowboarding exist, there has been no discussion of how neurocognitive deficits may influence such injuries. Recent authors have identified a possible link between Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) testing results and the prevalence of musculoskeletal injury in athletic populations. However, no study has specifically examined this in the alpine skiing and snowboard athletes who sustain injury and those that do not. Hypothesis/Purpose The purpose was to review injury data and ImPACT test results within the local ski/snowboard population to determine if there was a difference in components of ImPACT test scores between injured and non-injured athletes. It was hypothesized that differences would exist in component scores on ImPACT testing between injured and non-injured athletes. Study design Retrospective cohort study Methods Injury records and baseline ImPACT testing scores for 93 athletes aged 14-17 participating in a local ski and snowboard club during the 2009-2012 seasons were gathered retrospectively. Injuries documented for the lower and upper extremity included ligament sprains, muscle strains, contusions, dislocation/subluxation, fractures and concussions. Athletes who sustained any of these listed injuries were categorized within the injured athlete group. Each component of ImPACT test scores was compared between gender and for injury status within skiing and snowboarding disciplines using a series of two-way analysis of variance tests. Results There was no difference between non-injured and injured females as well as non-injured and injured males in reaction time and visual motor speed (VMS), however there was an interaction between gender and injury status on composite reaction time and visual motor speed, or VMS. The composite reaction time for females was 4.7% faster with injury while males without injury

  11. Plasma IMS Composition Measurements for Europa, Ganymede, and the Jovian System

    NASA Technical Reports Server (NTRS)

    Sittler, E. C., Jr.; Cooper, J. F.; Hartle, R. E.; Paterson, W. R.; Christian, E. R.; Lipatov, A. S.; Mahaffy, P R.; Paschalidis, N.; Sarantos, M.; Coplan, M. A.; Cassidy, T. A.; Wurz, P.

    2011-01-01

    NASA and ESA are now planning a reduced version of the joint Europa Jupiter System Mission (EJSM), potentially including a radically descoped Jupiter Europa Orbiter (JEO) but still with magnetometer and plasma instruments. Similar field and plasma instrumentation would also reside on ESA's Jupiter Ganymede Orbiter (JGO), which conceivably could carry out multiple flybys of Europa before entering orbit at Ganymede. We are developing the 3D Ion Mass Spectrometer (IMS) designed to measure both major and minor ion species within the high radiation environment of Jupiter's magnetosphere and the icy Galilean moons. The IMS covers the energy range from 10 eV to 30 keY, wide field-of-view (FOV) capability and 10-60 sec time resolution for major ions. This instrument has two main goals: 1) measure the plasma interaction between Europa and Jupiter's magnetosphere and 2) infer the global surface composition to trace elemental and significant isotopic levels; these goals are also applicable for in-situ measurements at Ganymede and Callisto, and remotely everywhere via the iogenic plasma for 10. The first goal supports the magnetometer (MAG) measurements, primarily directed at detection of Europa's sub-surface ocean, while the second goal gives information about transfer of material between the Galilean moons, e.g. mainly from 10 to the other moons, and further allows detection of oceanic materials emergent to the moon surfaces from subsurface layers putatively including salt water oceans. Outgassed exospheric materials are probed by the IMS by measuring pickup ions accelerated up to spacecraft altitudes of approximately 100-200 km in electric fields extending through the local magnetospheric environment and moon exosphere to the surface. Our 3D hybrid kinetic model of the moon-magnetosphere interaction is used to construct a global model of electric and magnetic fields for tracing of pickup ion trajectories back to the sources at approximate surface resolution of 100 km. We

  12. Plasma IMS Composition Measurements for Europa, Ganymede, and the Jovian Systems

    NASA Technical Reports Server (NTRS)

    Sittler, E.; Cooper, J.; Hartle, R.; Paterson ,W.; Christian, E.; Mahaffy, P.; Paschalidis, N.; Lipatov, A.; Sarantos, M.; Coplan, M.; Cassidy, T.; Wurz, P.

    2011-01-01

    NASA and ESA are now planning a reduced version of the joint Europa Jupiter System Mission (EJSM), potentially including a radically descoped Jupiter Europa Orbiter (JEO) but still with magnetometer and plasma instruments. Similar field and plasma instrumentation would also reside on ESA's Jupiter Ganymede Orbiter (JGO), which conceivably could carry out multiple flybys of Europa before entering orbit at Ganymede. We are developing the 3D Ion Mass Spectrometer (IMS) designed to measure both major and minor ion species within the high radiation environment of Jupiter s magnetosphere and the icy Galilean moons. The IMS covers the energy range from 10 eV to 30 keV, wide field-ofview (FOV) capability and 10-60 sec time resolution for major ions. This instrument has two main goals: 1) measure the plasma interaction between Europa and Jupiter s magnetosphere and 2) infer the global surface composition to trace elemental and significant isotopic levels; these goals are also applicable for in-situ measurements at Ganymede and Callisto, and remotely everywhere via the iogenic plasma for Io. The first goal supports the magnetometer (MAG) measurements, primarily directed at detection of Europa's sub-surface ocean, while the second goal gives information about transfer of material between the Galilean moons, e.g. mainly from Io to the other moons, and further allows detection of oceanic materials emergent to the moon surfaces from subsurface layers putatively including salt water oceans. Outgassed exospheric materials are probed by the IMS by measuring pickup ions accelerated up to spacecraft altitudes of approximately 100-200 km in electric fields extending through the local magnetospheric environment and moon exosphere to the surface. Our 3D hybrid kinetic model of the moon-magnetosphere interaction is used to construct a global model of electric and magnetic fields for tracing of pickup ion trajectories back to the sources at approximate surface resolution of 100 km. We

  13. Limitierungen bei der Ermittlung der Grundwasserfließrichtung in tiefen Aquiferen am Beispiel des Malms im Süddeutschen Molassebecken

    NASA Astrophysics Data System (ADS)

    Savvatis, Alexandros; Steiner, Ulrich; Huber, Bernhard; Fritzer, Thomas; Schneider, Michael

    2015-12-01

    The groundwater flow direction in deep inclined aquifers is generally determined from contour maps based on the conversion of the reservoir pressure from deep wells to standardized groundwater levels. The standardizing is done with a representative water column of constant density in which an increasing depth of the aquifer has an increasing influence on the calculated groundwater levels. However, integration of new pressure data from recently drilled geothermal wells in the Malm of the South German Molasse Basin in the greater area of Munich led to a hydrogeologically unrealistic groundwater flow direction below the Alps. The present work demonstrates the applied method for standardization, performs an error analysis, and shows the limits of the applicability of this method. An alternative approach is introduced along with a concrete example where the local flow direction is determined by neighboring wells (cluster method). A sensitivity analysis with respect to the uncertainty in temperature shows that this approach provides realistic results from realistic input scenarios. The presented cluster method is therefore able to provide pilot points for calibration/verification of a basin-scale groundwater flow model.

  14. Lichtkurve und Periode des RR-Lyrae-Sterns HO Her und GSC 02589-00332, ein W-UMa-Veraenderlicher im Feld

    NASA Astrophysics Data System (ADS)

    Groebel, Rainer

    2015-01-01

    Based on data from the SWASP database and on recent observations 110 maxima and 78 minima timings of the little studied star HO Her could be derived. During the reduction of SWASP data, discrepancies between magnitudes given by series taken simultaneously through different cameras appeared, so that in the present case the reliability of the TAMFLUX correction must be questioned. From the variations in amplitude, a regular secondary cycle could not be derived, but the variations in phase revealed a 17.4 d Blazhko period. Since the discovery, the period remains essentially constant. The ephemeris is improved to HJD (max.) = 2456802.4954(9) + 0.47269795(16) x E One of the comparison stars, GSC 02589-00332 (16:56:31.98 +30:22:22.5) revealed itself as a variable of the W UMa type presenting 0.6 mag. deep total eclipses at primary and 0.5 mag. partial eclipse at secondary minimum. As a variable, it is already known as ROTSE1 J165631.98+302222.0. From SWASP data, 138 minima spreading over 4 years could be derived. The 2014 minima showed positive (O-C) values, indicating a progressive lengthening of the period. The minima timings could be best represented by the quadratic ephemeris HJD (max.) = 2456797.5267 + 0.41111232 x E + 2.625*10 -10 x E^2

  15. Contaminant screening of wastewater with HPLC-IM-qTOF-MS and LC+LC-IM-qTOF-MS using a CCS database.

    PubMed

    Stephan, Susanne; Hippler, Joerg; Köhler, Timo; Deeb, Ahmad A; Schmidt, Torsten C; Schmitz, Oliver J

    2016-09-01

    Non-target analysis has become an important tool in the field of water analysis since a broad variety of pollutants from different sources are released to the water cycle. For identification of compounds in such complex samples, liquid chromatography coupled to high resolution mass spectrometry are often used. The introduction of ion mobility spectrometry provides an additional separation dimension and allows determining collision cross sections (CCS) of the analytes as a further physicochemical constant supporting the identification. A CCS database with more than 500 standard substances including drug-like compounds and pesticides was used for CCS data base search in this work. A non-target analysis of a wastewater sample was initially performed with high performance liquid chromatography (HPLC) coupled to an ion mobility-quadrupole-time of flight mass spectrometer (IM-qTOF-MS). A database search including exact mass (±5 ppm) and CCS (±1 %) delivered 22 different compounds. Furthermore, the same sample was analyzed with a two-dimensional LC method, called LC+LC, developed in our group for the coupling to IM-qTOF-MS. This four dimensional separation platform revealed 53 different compounds, identified over exact mass and CCS, in the examined wastewater sample. It is demonstrated that the CCS database can also help to distinguish between isobaric structures exemplified for cyclophosphamide and ifosfamide. Graphical Abstract Scheme of sample analysis and database screening. PMID:27497965

  16. Theoretical predictor for candidate structure assignment from IMS data of biomolecule-related conformational space

    PubMed Central

    Schenk, Emily R.; Nau, Frederic

    2016-01-01

    The ability to correlate experimental ion mobility data with candidate structures from theoretical modeling provides a powerful analytical and structural tool for the characterization of biomolecules. In the present paper, a theoretical workflow is described to generate and assign candidate structures for experimental trapped ion mobility and H/D exchange (HDX-TIMS-MS) data following molecular dynamics simulations and statistical filtering. The applicability of the theoretical predictor is illustrated for a peptide and protein example with multiple conformations and kinetic intermediates. The described methodology yields a low computational cost and a simple workflow by incorporating statistical filtering and molecular dynamics simulations. The workflow can be adapted to different IMS scenarios and CCS calculators for a more accurate description of the IMS experimental conditions. For the case of the HDX-TIMS-MS experiments, molecular dynamics in the “TIMS box” accounts for a better sampling of the molecular intermediates and local energy minima. PMID:27330407

  17. Das Programm Oder 2006. Hochwasserschutz in Polen im Zuge der EU-Osterweiterung

    NASA Astrophysics Data System (ADS)

    Kühne, Olaf

    Hochwasser ist ein natürliches Ereignis: Seit jeher sind die Menschen mit Hochwasser und seinen Auswirkungen konfrontiert. Das Ausmaß von Hochwasser reicht dabei von Straßenüberschwemmungen bis zur Überflutung ganzer Landesteile. Auch im Oderflußsystem waren und sind Überschwemmungen keine Seltenheit, in den letzten 200 Jahren ereigneten sie sich in den Jahren 1813, 1838, 1854, 1870, 1903, 1958, 1965, 1970, 1972, 1977, 1981, 1985 und 1997. Das Hochwasser von 1997 war jedoch das schwerste im genannten Zeitraum. Als Reaktion auf das Hochwasser von 1997 wurde in der betroffenen Region das Programm 〝Oder 2006`` entwickelt. Mit seiner Hilfe sollen die Auswirkungen künftiger Hochwasserereignisse abgeschwächt werden.

  18. Evaluation of SDS depletion using an affinity spin column and IMS-MS detection

    SciTech Connect

    Hengel, Shawna M.; Floyd, Erica A.; Baker, Erin Shammel; Zhao, Rui; Wu, Si; Pasa-Tolic, Ljiljana

    2012-11-01

    While the use of detergents is necessary for a variety of protein isolation preparation protocols, often prior to mass spectral (MS) analysis, they are not compatible with MS analysis due to ion suppression and adduct formation. This manuscript describes optimization of detergent removal, using commercially available SDS depletion spin columns containing an affinity resin, providing for both increased protein recovery and thorough SDS removal. Ion mobility spectrometry coupled with mass spectrometry (IMS-MS) allowed for a concurrent analysis of both analyte and detergent. In the case of both proteins and peptides, higher detergent concentrations than previously reported provided an increase of sample recovery; however there was a limit as SDS was detected by IMS-MS at higher levels of SDS indicating incomplete detergent depletion. The results also suggest optimal conditions for SDS removal are dependent on the sample concentration. Overall, this study provides a useful guide for proteomic studies where SDS is required for efficient sample preparation.

  19. OzDES Spectroscopic Classification of DES13X3woy

    NASA Astrophysics Data System (ADS)

    Yuan, F.; Childress, M.; Sharp, R.; Lidman, C.; Parkinson, D.; Mould, J.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; D'Andrea, C.; Nichol, R.; Papadopoulos, A.; Sullivan, M.; Maartens, R.; Smith, M.; Barbary, K.; Bernstein, J. P.; Biswas, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Bloom, J. S.; Goldstein, D.; Kim, A.; Nugent, P.; Perlmutter, S.; Thomas, R. C.; Foley, R. J.; Desai, S.; Paech, K.; Smith, R. C.; Schubnell, M.; Kessler, R.; Covarrubias, R. A.; Cane, R.; Fischer, J. A.; Gladney, L.; March, M.; Sako, M.

    2014-01-01

    We report spectroscopic classification by OzDES of a supernova discovered by the Dark Energy Survey (ATel #4668). The spectrum (370-885nm) was obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT). Object classification was performed using superfit (Howell and Wang, 2002, BAAS, 34, 1256), the details of which are reported in the table below.

  20. EVALUATION OF AN ALTERNATIVE IMS DISSOCIATION PROCEDURE FOR USE WITH METHOD 1622: DETECTION OF CRYPTOSPORIDIUM IN WATER

    EPA Science Inventory

    U.S. EPA Method 1623 is used to detect and quantify Cruptosporidum spp. oocysts in ater. The protocol consists of filtration, immunomagnetic separation (IMS), staining with a fluorescent antibody, and microscopic analysis. Microscopic analysis includes detection by fluorescent ...

  1. EVALUATION OF CRYPTOSPORIDIUM OOCYST RECOVERY IN WATER BY EPA METHOD 1623 WITH A MODIFIED IMS DISSOCIATION PROCEDURE.

    EPA Science Inventory

    EPA Methods 1622 and 1623 are the benchmarks for detection of Cryptosporidium spp. oocysts in water. 5-7 These methods consist of filtration, elution, purification by immunomagnetic separation (IMS), and microscopic analysis after staining with a fluorescein isothiocyanate conju...

  2. MALDI Imaging Mass Spectrometry (MALDI-IMS)—Application of Spatial Proteomics for Ovarian Cancer Classification and Diagnosis

    PubMed Central

    Gustafsson, Johan O. R.; Oehler, Martin K.; Ruszkiewicz, Andrew; McColl, Shaun R.; Hoffmann, Peter

    2011-01-01

    MALDI imaging mass spectrometry (MALDI-IMS) allows acquisition of mass data for metabolites, lipids, peptides and proteins directly from tissue sections. IMS is typically performed either as a multiple spot profiling experiment to generate tissue specific mass profiles, or a high resolution imaging experiment where relative spatial abundance for potentially hundreds of analytes across virtually any tissue section can be measured. Crucially, imaging can be achieved without prior knowledge of tissue composition and without the use of antibodies. In effect MALDI-IMS allows generation of molecular data which complement and expand upon the information provided by histology including immuno-histochemistry, making its application valuable to both cancer biomarker research and diagnostics. The current state of MALDI-IMS, key biological applications to ovarian cancer research and practical considerations for analysis of peptides and proteins on ovarian tissue are presented in this review. PMID:21340013

  3. A Sun in the Spectroscopic Binary IM Pegasi, the Guide Star for the Gravity Probe B Mission

    NASA Astrophysics Data System (ADS)

    Marsden, S. C.; Berdyugina, S. V.; Donati, J.-F.; Eaton, J. A.; Williamson, M. H.; Ilyin, I.; Fischer, D. A.; Muñoz, M.; Isaacson, H.; Ratner, M. I.; Semel, M.; Petit, P.; Carter, B. D.

    2005-12-01

    We present the first detection of the secondary of the spectroscopic binary system IM Pegasi (HR 8703), the guide star for the NASA-Stanford relativity gyroscope mission Gravity Probe B. In support of this mission, high-resolution echelle spectra of IM Peg have been obtained on an almost nightly basis. Applying the technique of least-squares deconvolution, we achieve very high signal-to-noise ratio line profiles and detect the orbit of the secondary of the system. Combining almost 700 new radial velocity measurements of both the primary and secondary of the system with previous measurements, we derive improved orbital parameters of the IM Peg system. Using these estimates along with the previously determined range of orbital inclination angles for the system, we find that the primary of IM Peg is a giant of mass 1.8+/-0.2 Msolar, while the secondary is a dwarf of mass 1.0+/-0.1 Msolar.

  4. Bewertung der Informationsqualität im Enterprise 2.0

    NASA Astrophysics Data System (ADS)

    Ahlheid, Sven; Graefe, Gernot; Krebs, Alexander; Schuster, Dirk

    Die Entwicklungen zum Web 2.0 haben das World Wide Web (WWW) grundlegend verändert. Nachdem die meisten Nutzer im WWW zunächst "nur" nach Informationen suchten stellen Nutzer inzwischen sehr ausgiebig Informationen über sich selbst oder ihnen vertraute Themen in Blogs und Communities bereit. Facebook und Wikipedia sind zwei prominente Webseiten. Ihre Attraktivität entstammt allein den Informationen, welche die Nutzer selber zur Verfügung stellen.

  5. Processing IMS data automatically: A case study of the Chelyabinsk bolide

    NASA Astrophysics Data System (ADS)

    Arrowsmith, S.; Marcillo, O. E.; Blom, P. S.; Whitaker, R. W.; Randall, G. E.

    2013-12-01

    We present automatic algorithms for detection, association, and location of infrasound events using the International Monitoring System (IMS) infrasound network. Each algorithm is based on probabilistic considerations that formally account for uncertainties at both the station and network levels. Our method is applied to two days of data that include infrasound signals from the Chelyabinsk bolide. We summarize the automatic detections, global association and localization of the bolide and discuss steps we are taking to improve the methodology based on these results.

  6. Prise en compte des ``courants de London'' dans la modélisation des supraconducteurs

    NASA Astrophysics Data System (ADS)

    Bossavit, Alain

    1997-10-01

    A model is given, in variational form, in which volumic “Bean currents”, ruled by Bean's law, and surface “London currents” coexist. This macroscopic model generalizes Bean's one, by appending to the critical density j_c a second parameter, with the dimension of a length, similar to London's depth λ. The one-dimensional version of the model is investigated, in order to link this parameter with the standard observable H-M characteristics On propose un modèle, sous forme variationnelle, associant des “courants de Bean” volumiques, décrits par la loi de Bean, et des “courants de London”, surfaciques. Ce modèle macroscopique généralise celui de Bean, caractérisé par le courant critique j_c, et fait intervenir un second paramètre, homogène à une longueur, analogue au λ de London. La version unidimensionnelle du modèle est étudiée en détail de manière à relier ce paramètre à l'observation des caractéristiques H-M usuelles.

  7. The coherent field of infrasound - a global view with the IMS

    NASA Astrophysics Data System (ADS)

    Ceranna, Lars; Le Pichon, Alexis

    2016-04-01

    In this study we are going to present preliminary results of global coherent infrasound measured at IMS infrasound stations and its correlation with atmospheric dynamics. A new implementation of the Progressive Multi-Channel Correlation (PMCC) algorithm has been used, which enables a better characterization of all received signals in their wave parameter space (e.g., frequency-azimuth space, frequency-trace-velocity space). This, in-turn, allows an accurate signal discrimination, as well as source and propagation studies. For instance, we are using the processing for microbarom source and propagation studies and for analysing the occurrence of mountain associated waves. We are currently performing re-processing of the entire previous IMS infrasound database covering the time period from January 2003 to December 2015; whereas the number of stations has increased from 6 to 48. Results so far indicate a continuous spectrum of coherent signals at IMS stations within the 0.02 to 5.0 Hz band. Moreover, these results could be used for estimating network detection capability based on empirical station coherent infrasound noise models.

  8. Evaluation of Preproduction Hardware Components for IMS Station Upgrades to Reduce Manufacturers Development Time

    NASA Astrophysics Data System (ADS)

    Hart, Darren; Pearce, Nathan; Starovoit, Yuri; Guralp, Cansun

    2014-05-01

    Since the Comprehensive Nuclear-Test-Ban Treaty was opened for signature in 1996, nearly 80% of the network has been certified as operational, and those stations are sending data to the International Data Centre (IDC) in Vienna. Several International Monitoring System (IMS) monitoring facilities have been in operation for close to 15 years, and several certified stations are facing equipment obsolescence issues. The search for engineering solutions to replace obsolete hardware components is guided by two primary goals: 1) be compliant with IMS minimum technical requirements and 2) be able to be integrated with the existing system. To reduce the development and verification time necessary to address obsolescence in equipment, the PTS has requested the preproduction testing of the recently revised Guralp CMG-DM24AM digitizer. Performing preproduction testing has helped in identifying issues, which Guralp Systems has resolved. In our poster, we will review the reasons for the digitizer updates, present results of the preproduction testing of the Guralp digitizer, and comment on the value this process has provided to the IMS operation.

  9. Ion mobility spectrometry-mass spectrometry (IMS-MS) for on- and offline analysis of atmospheric gas and aerosol species

    NASA Astrophysics Data System (ADS)

    Krechmer, Jordan E.; Groessl, Michael; Zhang, Xuan; Junninen, Heikki; Massoli, Paola; Lambe, Andrew T.; Kimmel, Joel R.; Cubison, Michael J.; Graf, Stephan; Lin, Ying-Hsuan; Budisulistiorini, Sri H.; Zhang, Haofei; Surratt, Jason D.; Knochenmuss, Richard; Jayne, John T.; Worsnop, Douglas R.; Jimenez, Jose-Luis; Canagaratna, Manjula R.

    2016-07-01

    Measurement techniques that provide molecular-level information are needed to elucidate the multiphase processes that produce secondary organic aerosol (SOA) species in the atmosphere. Here we demonstrate the application of ion mobility spectrometry-mass spectrometry (IMS-MS) to the simultaneous characterization of the elemental composition and molecular structures of organic species in the gas and particulate phases. Molecular ions of gas-phase organic species are measured online with IMS-MS after ionization with a custom-built nitrate chemical ionization (CI) source. This CI-IMS-MS technique is used to obtain time-resolved measurements (5 min) of highly oxidized organic molecules during the 2013 Southern Oxidant and Aerosol Study (SOAS) ambient field campaign in the forested SE US. The ambient IMS-MS signals are consistent with laboratory IMS-MS spectra obtained from single-component carboxylic acids and multicomponent mixtures of isoprene and monoterpene oxidation products. Mass-mobility correlations in the 2-D IMS-MS space provide a means of identifying ions with similar molecular structures within complex mass spectra and are used to separate and identify monoterpene oxidation products in the ambient data that are produced from different chemical pathways. Water-soluble organic carbon (WSOC) constituents of fine aerosol particles that are not resolvable with standard analytical separation methods, such as liquid chromatography (LC), are shown to be separable with IMS-MS coupled to an electrospray ionization (ESI) source. The capability to use ion mobility to differentiate between isomers is demonstrated for organosulfates derived from the reactive uptake of isomers of isoprene epoxydiols (IEPOX) onto wet acidic sulfate aerosol. Controlled fragmentation of precursor ions by collisionally induced dissociation (CID) in the transfer region between the IMS and the MS is used to validate MS peak assignments, elucidate structures of oligomers, and confirm the

  10. Characterization of the Glycosyltransferase DesVII and Its Auxiliary Partner Protein DesVIII in the Methymycin/Pikromycin Biosynthetic Pathway†

    PubMed Central

    Borisova, Svetlana A.; Liu, Hung-wen

    2010-01-01

    The in vitro characterization of the catalytic activity of DesVII, the glycosyltransferase involved in the biosynthesis of the macrolide antibiotics methymycin, neomethymycin, narbomycin, and pikromycin in Streptomyces venezuelae, is described. DesVII is unique among glycosyltransferases in that it requires an additional protein component, DesVIII, for activity. Characterization of the metabolites produced by a S. venezuelae mutant lacking desVIII gene confirmed that desVIII is important for the biosynthesis of glycosylated macrolides, but can be replaced by at least one of the homologous genes from other pathways. The addition of recombinant DesVIII protein significantly improves the glycosylation efficiency of DesVII in the in vitro assay. When affinity-tagged DesVII and DesVIII proteins were co-produced in E. coli, they formed a tight (αβ)3 complex that is at least 103-fold more active than DesVII alone. The formation of the DesVII/DesVIII complex requires co-expression of both genes in vivo and cannot be fully achieved by mixing the individual protein components in vitro. The ability of DesVII/DesVIII system to catalyze the reverse reaction with the formation of TDP-desosamine was also demonstrated in a transglycosylation experiment. Taken together, our data suggest that DesVIII assists the folding of DesVII during protein production and remains tightly bound during catalysis. This requirement must be taken into consideration in the design of combinatorial biosynthetic experiments of new glycosylated macrolides. PMID:20695498

  11. Im10A, a short conopeptide isolated from Conus imperialis and possesses two highly concentrated disulfide bridges and analgesic activity.

    PubMed

    Yu, Shuo; Du, Tianpeng; Liu, Zhuguo; Wu, Qiaoling; Feng, Guixue; Dong, Mingxin; Zhou, Xiaowei; Jiang, Ling; Dai, Qiuyun

    2016-07-01

    In the present study, we isolated, synthesized and NMR structurally characterized a novel conopeptide Im10A consisting of 11 amino acids (NTICCEGCMCY-NH2) from Conus imperialis. Unlike other conopeptides with four cysteine residues, Im10A had only two residues in loop 1 and one residue in loop 2 (CC-loop1-C-loop2-C), which formed a stable disulfide connectivity "I-IV, II- III" (framework X) with a type I β-turn. Interestingly, Im10A exhibited 50.7% analgesic activity on rat partial sciatic nerve ligation (PNL) at 2h after Im10A administration. However, 10μM Im10A exhibited no apparent effect on neuronal nicotinic acetylcholine receptor, and it did not target DRG voltage-dependent sodium, potassium and calcium ion channels and opioid receptor. To our knowledge, Im10A had the most concentrated disulfide bridges among conopeptides with four cysteine residues. This finding provided a new motif for the future development of biomimetic compounds. PMID:27131596

  12. Determination of acetamiprid and IM-1-2 in postmortem human blood, liver, stomach contents by HPLC-DAD.

    PubMed

    Yeter, Oya; Aydın, Adnan

    2014-01-01

    An HPLC-DAD method was developed to detect and quantify a neonicotinoid insecticide acetamiprid (ATP) and its metabolite IM-1-2 in autopsy samples of a fatal intoxication case. The postmortem blood and tissue distribution of ATP and IM-1-2 was determined for the first time. The method showed acceptable precisions and recoveries with relative standard deviations of <10% for ATP level and 1.38 % for IM-1-2. The detection and quantification limits for ATP were 0.015 μg/mL and 0.030 μg/mL for blood and were 0.035 μg/g and 0.050 μg/g for liver samples, respectively. The mean contents of ATP were 0.79 μg/g in the liver, 47.35 μg/g in the stomach contents and 2.7 μg/mL in the blood. IM-1-2 content was 17.0 μg/g in the stomach contents. ATP and IM-1-2 were not detected in the urine. The presence of ATP and IM-1-2 in the samples was confirmed by GC-MS. The method can be exploited in future forensic casework. PMID:24329162

  13. Formation et Evolution des Quasars et Contraintes cosmologiques

    NASA Astrophysics Data System (ADS)

    Hatziminaoglou, Evanthia

    2000-06-01

    Cette thèse porte sur l'étude de l'évolution des quasars. Elle en aborde certains aspects théoriques et observationnels, ainsi que la construction des grands échantillons de quasars dans le but à long terme de combiner le tout dans un test cosmologique géométrique pour déterminer les valeurs des paramètres cosmologiques Omega et Lambda. Les paramètres cosmologiques Omegaspan>et Lambdaspan>décrivent la géométrie globale de l'Univers. En faisant des hypothèses raisonnables sur la distribution spatiale et l'évolution des objets astrophysiques (galaxies, amas des galaxies, quasars), on peut déterminer les valeurs de ces paramètres qui sont cohérentes avec ces hypothèses. Les tests cosmologiques traditionnels ont besoin de ''chandelles standards'', objets dont les propriétés intrinsèques sont indépendantes des distances. De tels objets sont probablement fictifs. Néanmoins, certains de ces tests cosmologiques peuvent être adaptés si l'évolution individuelle, ou au moins l'évolution statistique d'une population d'objets est connue. La question de la nature de l'évolution des quasars a très vite été posée et des réponses ''phénoménologiques'' ont d'abord été données. Ces réponses ne faisaient que donner une forme mathématique à l'évolution mais n'expliquaient rien de la physique duphénomène. Les premières tentatives de construction d'un modèle physique, liées au processus d'accrétion sur un trou noir et à la théorie de la formation de l'Univers ont commencé à la fin des années 80. Depuis, des dizaines de modèles tentent d'expliquer les observations, qui sont les résultats de l'étude d'objets de plus en plus nombreux. Au cours de cette thèse, le test V/Vmax a été appliqué sur l'échantillon du Large Bright Quasar Survey en montrant 1) que l'échantillon était biaisé à cause des critères de sélection et 2) que la (simple) loi de Pure Evolution en Luminosité n'était pas une bonne approximation à tout

  14. Discovery and Classification of DES15S2kqw

    NASA Astrophysics Data System (ADS)

    Kasai, E.; Bassett, B.; Crawford, S.; Kniazev, A.; Childress, M.; D'Andrea, C.; Smith, M.; Sullivan, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Kim, A. G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Foley, R. J.; Casas, R.; Castander, F. J.; Desai, S.; Paech, K.; Smith, R. C.; Schubnell, M.; Kessler, R.; Lasker, J.; Scolnic, D.; Brout, D. J.; Gladney, L.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; Nichol, R.; Papadopoulos, A.

    2015-10-01

    We report optical spectroscopy of DES15S2kqw discovered by the Dark Energy Survey. The spectrum (380-820nm) was obtained using the Robert Stobie Spectrograph (RSS) on the South African Large Telescope (SALT).

  15. La détermination des distances: Sol, Hipparcos, GAIA.

    NASA Astrophysics Data System (ADS)

    Turon, C.

    Les parallaxes trigonométriques des étoiles les plus proches du soleil sont la base de la détermination des distances dans l'Univers. Elles permettent, par la calibration en luminosité des différents indicateurs de distance d'étalonner les distances d'abord dans notre Galaxie, puis dans les galaxies du Groupe Local, puis pour les galaxies plus lointaines. Cette base est, actuellement, très mince, et peu de types d'étoiles y sont représentés. Hipparcos va déjà apporter une amélioration sensible. Avec GAIA une révision complète des calibrations de luminosité de tous les indicateurs "primaires" serait directement possible.

  16. A study of volcanic eruption characteristics using infrasound data recorded on the global IMS network

    NASA Astrophysics Data System (ADS)

    Dabrowa, Amy; Green, David; Phillips, Jeremy; Rust, Alison

    2010-05-01

    Explosive volcanic eruptions have the capability to generate sound waves with infrasonic frequencies (<20Hz). As such waves can propagate over distances of thousands of kilometres within the atmosphere, they present an opportunity to remotely monitor volcanic eruptions and potentially constrain eruptive characteristics. Though most volcanoes in sensitive areas of the world are monitored individually, many volcanoes in remote locations are not monitored directly but can still pose a threat, especially to aviation. The growing International Monitoring System (IMS) network of infrasound stations provides an opportunity to monitor these remote volcanoes. Currently comprising of 43 arrays, the network is designed to achieve global coverage for surface explosions equivalent to a few hundred tonnes of chemical explosive. In recent years work has been published on the detection of specific volcanic eruptions at IMS stations, primarily at regional ranges (< 1000 km from volcano to receiver). In contrast, work presented here looks to create a catalogue of volcanic eruptions that have been detected at IMS stations, with the aim of assessing the capability of the IMS network for use in global volcano monitoring. At this time 40 eruptive events at 19 volcanoes have been investigated from the period 2004 - 2009; however the work is on-going and it is planned to extend this catalogue. In total we document 61 individual detections that have been made on the IMS network. These range from Strombolian activity at Mount Erebus (Antarctica) recorded at a range of 25 km distance, to the Plinian eruption of Manam Volcano (Papua New Guinea) recorded at ranges of over 10,000 km distance. The observed signal frequencies for different eruptions range from less than 0.01 Hz to greater than 5 Hz, and in general, lower frequencies are generated by the larger eruptions. We provide examples of analyses for eruptions recorded at multiple stations (e.g., Manam, October 2004; Kasatochi, August 2008

  17. Developing integrated TOF-SIMS/MALDI IMS system in studying biological systems

    NASA Astrophysics Data System (ADS)

    Wu, Ligang

    Using imaging mass spectrometry (IMS) techniques (including TOF-SIMS and MALDI IMS) to study biological systems is a relatively new concept and quickly gained popularity in recent years. Imaging mass spectrometry is a discovery technology that utilizes a focused ion beam or laser beam to desorb ions from sample surface. By detecting the desorbed ions, the chemical distributions and biological changes of a sample surface can be analyzed. These techniques offer a new analytical imaging approach to investigate biological processes at the cellular and tissue level. In this research, a novel integrated TOF-SIMS/MALDI IMS system as well as IMS based biological-sample-preparation techniques and data-reduction methods are developed. We then demonstrate the power of these techniques in studying different biological systems, including monosaccharides isomers, human breast cancer cell lines, mouse embryo tissues and mouse kidney sections. Using TOF-SIMS and statistical analysis methods, seven monosaccharide isomers are fully differentiated by analyzing their characteristic spectral pattern. In addition, a deep understanding of the fragmentation pathway of these isomers under ion bombardment is gained. In an application of TOF-SIMS to the differentiation of three human breast cancer cell lines, MCF-7, T47D, and MDA-MB-231, we show that principal component analysis (PCA) data reduction of TOF-SIMS spectra can differentiate cellular compartments (cytosol, nuclear and particulate) within the cell types, as well as homogenates from among the three cell lines. In a tissue-specific application, we extend the analytical capabilities of TOF-SIMS and PCA by imaging and differentiating Formalin-fixed paraffin-embedded (FFPE) mouse embryo tissues. We demonstrate reproducible differentiation of six tissue types based on the remaining small molecules after paraffin-embedding and the fragments of the cellular proteins. In a unique study of fresh frozen mouse kidney tissues, both TOF

  18. ImSET 3.1: Impact of Sector Energy Technologies Model Description and User's Guide

    SciTech Connect

    Scott, Michael J.; Livingston, Olga V.; Balducci, Patrick J.; Roop, Joseph M.; Schultz, Robert W.

    2009-05-22

    This 3.1 version of the Impact of Sector Energy Technologies (ImSET) model represents the next generation of the previously-built ImSET model (ImSET 2.0) that was developed in 2005 to estimate the macroeconomic impacts of energy-efficient technology in buildings. In particular, a special-purpose version of the Benchmark National Input-Output (I-O) model was designed specifically to estimate the national employment and income effects of the deployment of Office of Energy Efficiency and Renewable Energy (EERE)–developed energy-saving technologies. In comparison with the previous versions of the model, this version features the use of the U.S. Bureau of Economic Analysis 2002 national input-output table and the central processing code has been moved from the FORTRAN legacy operating environment to a modern C++ code. ImSET is also easier to use than extant macroeconomic simulation models and incorporates information developed by each of the EERE offices as part of the requirements of the Government Performance and Results Act. While it does not include the ability to model certain dynamic features of markets for labor and other factors of production featured in the more complex models, for most purposes these excluded features are not critical. The analysis is credible as long as the assumption is made that relative prices in the economy would not be substantially affected by energy efficiency investments. In most cases, the expected scale of these investments is small enough that neither labor markets nor production cost relationships should seriously affect national prices as the investments are made. The exact timing of impacts on gross product, employment, and national wage income from energy efficiency investments is not well-enough understood that much special insight can be gained from the additional dynamic sophistication of a macroeconomic simulation model. Thus, we believe that this version of ImSET is a cost-effective solution to estimating the economic

  19. E9-Im9 Colicin DNase−Immunity Protein Biomolecular Association in Water: A Multiple-Copy and Accelerated Molecular Dynamics Simulation Study

    PubMed Central

    2008-01-01

    Protein−protein transient and dynamic interactions underlie all biological processes. The molecular dynamics (MD) of the E9 colicin DNase protein, its Im9 inhibitor protein, and their E9-Im9 recognition complex are investigated by combining multiple-copy (MC) MD and accelerated MD (aMD) explicit-solvent simulation approaches, after validation with crystalline-phase and solution experiments. Im9 shows higher flexibility than its E9 counterpart. Im9 displays a significant reduction of backbone flexibility and a remarkable increase in motional correlation upon E9 association. Im9 loops 23−31 and 54−64 open with respect to the E9-Im9 X-ray structure and show high conformational diversity. Upon association a large fraction (∼20 nm2) of E9 and Im9 protein surfaces become inaccessible to water. Numerous salt bridges transiently occurring throughout our six 50 ns long MC-MD simulations are not present in the X-ray model. Among these Im9 Glu31−E9 Arg96 and Im9 Glu41−Lys89 involve interface interactions. Through the use of 10 ns of Im9 aMD simulation, we reconcile the largest thermodynamic impact measured for Asp51Ala mutation with Im9 structure and dynamics. Lys57 acts as an essential molecular switch to shift Im9 surface loop towards an ideal configuration for E9 inhibition. This is achieved by switching Asp60−Lys57 and Asp62−Lys57 hydrogen bonds to Asp51−Lys57 salt bridge. E9-Im9 recognition involves shifts of conformational distributions, reorganization of intramolecular hydrogen bond patterns, and formation of new inter- and intramolecular interactions. The description of key transient biological interactions can be significantly enriched by the dynamic and atomic-level information provided by computer simulations. PMID:19053689

  20. Modellierung des Einflusses der Landnutzung auf die Hochwasserentstehung in der Mesoskala

    NASA Astrophysics Data System (ADS)

    Niehoff, Daniel

    2001-10-01

    Seit 1990 waren mehrere der großen Flussgebiete Mitteleuropas wiederholt von extremen Hochwassern betroffen. Da sowohl die Landoberfläche als auch die Flusssysteme weiter Teile Mitteleuropas in der Vergangenheit weitreichenden Eingriffen ausgesetzt gewesen sind, wird bei der Suche nach den Ursachen für diese Häufung von Extremereignissen auch die Frage nach der Verantwortung des Menschen hierfür diskutiert. Gewässerausbau, Flächenversiegelung, intensive landwirtschaftliche Bodenbearbeitung, Flurbereinigung und Waldschäden sind nur einige Beispiele und Folgen der anthropogenen Eingriffe in die Landschaft. Aufgrund der Vielfalt der beteiligten Prozesse und deren Wechselwirkungen gibt es allerdings bislang nur Schätzungen darüber, wie sehr sich die Hochwassersituation hierdurch verändert hat. Vorrangiges Ziel dieser Arbeit ist es, mit Hilfe eines hydrologischen Modells systematisch darzustellen, in welcher Weise, in welcher Größenordnung und unter welchen Umständen die Art der Landnutzung auf die Hochwasserentstehung Einfluss nimmt. Dies wird anhand exemplarischer Modellanwendungen in der hydrologischen Mesoskala untersucht. Zu diesem Zweck wurde das deterministische und flächendifferenzierte hydrologische Modell wasim-eth ausgewählt, das sich durch eine ausgewogene Mischung aus physikalisch begründeten und konzeptionellen Ansätzen auszeichnet. Das Modell wurde im Rahmen dieser Arbeit um verschiedene Aspekte erweitert, die für die Charakterisierung des Einflusses der Landnutzung auf die Hochwasserentstehung wichtig sind: (1) Bevorzugtes Fließen in Makroporen wird durch eine Zweiteilung des Bodens in Makroporen und Bodenmatrix dargestellt, die schnelle Infiltration und Perkolation jenseits der hydraulischen Leitfähigkeit der Bodenmatrix ermöglicht. (2) Verschlämmung äußert sich im Modell abhängig von Niederschlagsintensität und Vegetationsbedeckungsgrad als Verschlechterung der Infiltrationsbedingungen an der Bodenoberfläche. (3) Das

  1. Physical characteristics of stream subbasins in the Des Moines River, Upper Des Moines River, and East Fork Des Moines River basins, southern Minnesota and northern Iowa

    USGS Publications Warehouse

    Sanocki, Christopher A.

    2000-01-01

    Data that describe the physical characteristics of stream subbasins upstream from selected sites on streams in the Des Moines River, Upper Des Moines River, and East Fork Des Moines River Basins, located in southwestern Minnesota, and northwestern Iowa, are presented in this report. The physical characteristics are the drainage area of the subbasin, the percentage area of the subbasin covered only by lakes, the percentage area of the subbasin covered by both lakes and wetlands, the main-channel length, and the main-channel slope. Stream sites include outlets of subbasins of at least 5 square miles, and locations of U.S. Geological Survey high-flow, and continuous-record gaging stations.

  2. Rôle des hyrates dans la formation de Titan et des satellites réguliers

    NASA Astrophysics Data System (ADS)

    Mousis, O.

    2001-12-01

    Cette these est dediee a l'etude de l'origine de Titan et de son atmosphere. Dans l'hypothese ou la subnebuleuse de Saturne etait geometriquement mince, le modele de disque turbulent utilise, derive des travaux de Dubrulle (1993), est moins dense que le modele de Prinn et Fegley (1981). De ce fait, les conversions de Co en CH4 et de N2 en NH3 ont ete inhibees dans la subnebuleuse, contrairement a ce qui est couramment admis pour interpreter la presence du methane dans l'atmosphere de Titan. C'est pourquoi nous avons developpe un nouveau scenario de la formation de titan, qui tient compte simultanement des contraintes resultant de la chimie de la subnebuleuse et des abondances de CH4, N2 et CH3D mesurees dans l'atmosphere du satellite. Nous faisons l'hypothese que ces gaz proviennent initialement de la vaporisation du nuage presolaire, qui s'effondra et forma le Soleil et son disque environnant. Lors du refroidissement de la nebuleuse, les volatils auraient ete pieges sous formes de clathrates d'hydrates dans les grains, puis dans les planetesimaux qu'ils formerent. Les planetesimaux hydrates a l'origine de la formation de Titan seraient alors des rescapes de l'effondrement hydsrodynamique de la feeding zone de Saturne. Ce scenario a ete applique aux subnebuleuses de Jupiter et d'Uranus, et a apporte un certain nombre de contraintes sur la formation des satellites reguliers de ces planetes. Le temps et la zone de formation des grains cometaires ont egalement ete estimes dans la nebuleuse solaire. Enfin, l'etude experimentale de la temperature de fusion du dihydrate d'ammoniac dans la gamme des hautes pressions a apporte des nouvelles donnees thermodynamiques qui permettront d'ameliorer les modeles de l'interieur de Titan.

  3. Les sarcomes des tissus mous: à propos de 33 cas

    PubMed Central

    Abdou, Jiddou; Elkabous, Mustapha; M'rabti, Hind; Errihani, Hassan

    2015-01-01

    L'objectif de cette étude est de rapporter les particularités épidémiologiques, cliniques, histologiques, thérapeutiques et évolutives des sarcomes des tissus mous à l'Institut National d'Oncologie et de définir les facteurs influençant la survie des patients. C'est une étude rétrospective de 33 cas de sarcome des tissus mous, colligés entre janvier 2008 et décembre 2010. Les critères d’éligibilité étaient un âge supérieur à 16 ans, une épreuve histologique d'un sarcome des tissus mous à l'exclusion des tumeurs stromales gastro-intestinales (GIST). Les items recueillis étaient: épidémiologiques, cliniques, histologiques, Radiologiques, et thérapeutiques. Des analyses univariées puis multivariées ont été réalisées à la recherche de facteurs influençant la survie à 2 ans. Il s'agit de 33 cas, 17 Hommes et 16 Femmes, l’âge moyen était de 43,21 ans (Extrêmes= 18-76 ans). La tumeur était localisée aux extrémités dans 24 cas (72,72%). Le type histologique prédominant était le Liposarcome dans 9 cas (27,27%). Le stade tumoral était localisé dans 25 cas (75,8%), métastatique dans 8 cas (24,2%). Vingt-cinq tumeurs ont été traitées chirurgicalement dont 21 cas (84%) de chirurgie conservatrice et 4 cas (16%) de chirurgie radicale. La radiothérapie a été réalisée chez 10 patients (30,3%). La chimiothérapie a été faite chez 20 patients. En analyse univariée les facteurs pronostiques étaient l’âge (p=0,03) et le stade tumoral (p=0,09). L’âge et le stade tumoral sont des facteurs pronostiques influençant la survie des sarcomes des tissus mous. PMID:27022434

  4. Alkaline earth imidazolate coordination polymers by solvent free melt synthesis as potential host lattices for rare earth photoluminescence: (x)(∞)[AE(Im)2(ImH)(2-3)], Mg, Ca, Sr, Ba, x = 1-2.

    PubMed

    Zurawski, Alexander; Rybak, J-Christoph; Meyer, Larissa V; Matthes, Philipp R; Stepanenko, Vladimir; Dannenbauer, Nicole; Würthner, Frank; Müller-Buschbaum, Klaus

    2012-04-14

    The series of alkaline earth elements magnesium, calcium, strontium and barium yields single crystalline imidazolate coordination polymers by reactions of the metals with a melt of 1H-imidazole: (1)(∞)[Mg(Im)(2)(ImH)(3)] (1), (2)(∞)[AE(Im)(2)(ImH)(2)], AE = Ca (2), Sr (3), and (1)(∞)[Ba(Im)(2)(ImH)(2)] (4). No additional solvents were used for the reactions. Co-doping experiments by addition of the rare earth elements cerium, europium and terbium were carried out. They indicate (2)(∞)[Sr(Im)(2)(ImH)(2)] as a possible host lattice for cerium(III) photoluminescence showing a blue emission and thus a novel blue emitting hybrid material phosphor 3:Ce(3+). Co-doping with europium and terbium is also possible but resulted in formation of (3)(∞)[Sr(Im)(2)]:Ln, Ln = Eu and Tb (5), with both exhibiting green emission of either Eu(2+) or Tb(3+). The other alkaline earth elements do not show acceptance of the rare earth ions investigated and a different structural chemistry. For magnesium and barium one-dimensional strand structures are observed whereas calcium and strontium give two-dimensional network structures. Combined with an increase of the ionic radii of AE(2+) the coordinative demand is also increasing from Mg(2+) to Ba(2+), reflected by four different crystal structures for the four elements Mg, Ca, Sr, Ba in 1-4. Different linkages of the imidazolate ligands result in a change from complete σ-N coordination in 1 to additional η(5)-π coordination in 4. The success of co-doping with different lanthanide ions is based on a match in the chemical behaviour and cationic radii. The use of strontium for host lattices with imidazole is a rare example in coordination chemistry of co-doping with small amounts of luminescence centers and successfully reduces the amount of high price rare earth elements in hybrid materials while maintaining the properties. All compounds are examples of pure N-coordinated coordination polymers of the alkaline earth metals and were

  5. Caractérisation des convertisseurs matriciels : II. Synthèse des fonctions de connexion

    NASA Astrophysics Data System (ADS)

    François, B.; Cambronne, J. P.; Hautier, J. P.

    1996-05-01

    Knowing the wished conversion levels (-1,0,1) of a power converter, this paper describes a particular method for setting the corresponding states of switches into the matrix converter. In a first step, a mathematical analysis establishes the relations linking the states of switches with the conversion functions. Afterwards, the presented method gives the inverse relations which constitute the sequential part of the converter control. The turn-on and the turn-off sequences are designed by considering the on-line wished level conversions. This general method enhances the idea that a converter functionnality must be defined by its structure and its control. Cet article propose une méthode originale pour définir la séquence de commande d'un convertisseur à partir de la fonction de conversion globalement souhaitée. Les auteurs procèdent d'abord à une analyse mathématique précise des relations qui existent entre les états des interrupteurs et les fonctions de conversion obtenues. À partir de cette analyse, la méthode developpée permet d'établir systématiquement les relations inverses qui constituent alors le module séquentiel de la commande rapprochée du convertisseur. Les ordres d'ouverture et de fermeture des interrupteurs sont élaborés en considérant à tout instant les niveaux de conversion souhaités pour les grandeurs électriques. Cette méthode générale renforce l'idée que la fonction remplie par un convertisseur moderne doit être définie à la fois par sa structure et sa commande.

  6. La planification préalable des soins pour les patients en pédiatrie

    PubMed Central

    2008-01-01

    RÉSUMÉ Les progrès médicaux et technologiques ont permis d’ac-croître les taux de survie et d’améliorer la qualité de vie des nourrissons, des enfants et des adolescents ayant des maladies chroniques mettant la vie en danger. La planifi-cation préalable des soins inclut le processus relié aux discussions sur les traitements essentiels au maintien de la survie et la détermination des objectifs des soins de longue durée. Les dispensateurs de soins pédiatriques ont l’obligation éthique d’assimiler cet aspect des soins médicaux. Le présent document de principes vise à aider les dispensateurs de soins à discuter de la planification préalable des soins des patients pédiatriques dans diverses situations. La planification préalable des soins exige des communications efficaces afin de clarifier les objectifs des soins et de s’entendre sur les traitements pertinents ou non pour réaliser ces objectifs, y compris les mesures de réanimation et les mesures palliatives.

  7. Bisthienylethene Th2im and its complex (Th2imH)2[ReCl6]: crystalline-phase photochromism, and photochemical regulation of luminescence and magnetic properties.

    PubMed

    Gong, Dan-Ping; Chen, Jun-Feng; Zhao, Yue; Cao, Deng-Ke

    2016-02-16

    Molecular assembly of bisthienylethene Th2im () and [ReCl6](2-) anions leads to the complex (Th2imH)2[ReCl6] (), in which a [ReCl6](2-) anion connects two equivalent Th2imH(+) cations through ClN/C hydrogen bonds. Crystal structures of and indicate that two thiophene groups of each Th2im/Th2imH(+) molecule adopt a photoactive antiparallel conformation. Thus, two compounds show crystalline-phase photochromism (CPP), i.e. reversible structural transformation between the open form and the closed form upon alternately irradiating the sample with UV light (365 nm) and visible light (574 nm for , 624 nm for ). It was found that the CPP behaviors of and could regulate their luminescence and/or magnetic properties. Their solid-state emissions (433, 448, 482, 531 and 570 nm for , and 460, 489, 535 and 593 nm for ) exhibited weaker intensities after UV irradiation with 365 nm light. Besides CPP and luminescence, compound shows field-induced slow magnetic relaxation. Before and after UV irradiation, this compound revealed different magnetic behaviors, including the differences in the shape of the χMT vs. T plot, D parameter, and the values of the relaxation barrier Ueff and the preexponential factor τ0. PMID:26790478

  8. 2 CFR 3513.137 - Who in Ex-Im Bank may grant an exception to let an excluded person participate in a covered...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Who in Ex-Im Bank may grant an exception to... NONPROCUREMENT DEBARMENT AND SUSPENSION General § 3513.137 Who in Ex-Im Bank may grant an exception to let an excluded person participate in a covered transaction? (a) The Ex-Im Bank agency head or designee may...

  9. 2 CFR 3513.137 - Who in Ex-Im Bank may grant an exception to let an excluded person participate in a covered...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Who in Ex-Im Bank may grant an exception to... NONPROCUREMENT DEBARMENT AND SUSPENSION General § 3513.137 Who in Ex-Im Bank may grant an exception to let an excluded person participate in a covered transaction? (a) The Ex-Im Bank agency head or designee may...

  10. De l'importance des orbites periodiques: Detection et applications

    NASA Astrophysics Data System (ADS)

    Doyon, Bernard

    L'ensemble des Orbites Periodiques Instables (OPIs) d'un systeme chaotique est intimement relie a ses proprietes dynamiques. A partir de l'ensemble (en principe infini) d'OPIs cachees dans l'espace des phases, on peut obtenir des quantites dynamiques importantes telles les exposants de Lyapunov, la mesure invariante, l'entropie topologique et la dimension fractale. En chaos quantique (i.e. l'etude de systemes quantiques qui ont un equivalent chaotique dans la limite classique), ces memes OPIs permettent de faire le pont entre le comportement classique et quantique de systemes non-integrables. La localisation de ces cycles fondamentaux est un probleme complexe. Cette these aborde dans un premier temps le probleme de la detection des OPIs dans les systemes chaotiques. Une etude comparative de deux algorithmes recents est presentee. Nous approfondissons ces deux methodes afin de les utiliser sur differents systemes dont des flots continus dissipatifs et conservatifs. Une analyse du taux de convergence des algorithmes est aussi realisee afin de degager les forces et les limites de ces schemes numeriques. Les methodes de detection que nous utilisons reposent sur une transformation particuliere de la dynamique initiale. Cette astuce nous a inspire une methode alternative pour cibler et stabiliser une orbite periodique quelconque dans un systeme chaotique. Le ciblage est en general combine aux methodes de controle pour stabiliser rapidement un cycle donne. En general, il faut connaitre la position et la stabilite du cycle en question. La nouvelle methode de ciblage que nous presentons ne demande pas de connaitre a priori la position et la stabilite des orbites periodiques. Elle pourrait etre un outil complementaire aux methodes de ciblage et de controle actuelles.

  11. Catalog Production for the DES Blind Cosmology Challenge

    NASA Astrophysics Data System (ADS)

    Busha, Michael T.; Wechsler, R. H.; Becker, M. R.; Erickson, B.; Evrard, A. E.

    2013-01-01

    The Blind Cosmology Challenge (BCC) is an effort by the Dark Energy Survey (DES) to test analysis tools for extracting cosmological information using a set of detailed synthetic galaxy catalogs. Here, we describe the creation of these synthetic sky catalogs based on requirements of the optical (DES) and the near-IR VISTA Hemisphere Survey, producing catalogs covering a quarter of the sky to z ˜ 2, with sources complete to r ˜ 25. Starting with a nested set of lightcone outputs of large, N-body simulation, galaxies are assigned to the dark matter distribution using an empirical algorithm that is tunable to match observed evolution of low-order galaxy population properties (counts and spatial clustering) in luminosity-color-density space. Galaxies are lensed by matter along the line of sight (including magnification, shape distortion, and multiple images), using a new algorithm that calculates shear with 3.22 arcsec resolution at galaxy positions in the full catalog. The catalog is well suited to support DES+VISTA joint studies of galaxy clustering, groups and clusters of galaxies, and gravitational lensing, and we highlight their application to the ongoing DES BBCC. Catalogs include ˜320 million galaxies and ˜150 million stars, with realistic colors, shapes and photometric errors. Using the expected DES photometric errors, three independent photometric redshift codes are run on the catalog, two of which produce full probability distributions. The synthetic observable catalog includes object position, magnitudes in the DES and VISTA bands, photometric errors, photometric redshifts, size, ellipticity, for each of ˜ 500 million objects. The galaxy distribution is additionally masked appropriately for the 5000 square degree DES footprint, including the impact of bright stars. In addition, we offer separate catalogs with magnitudes for additional existing and planned surveys, including SDSS, CFHTLS, HSC, LSST, and Euclid.

  12. MALDI FTICR IMS of intact proteins: Using mass accuracy to link protein images with proteomics data

    PubMed Central

    Spraggins, Jeffrey M.; Rizzo, David G.; Moore, Jessica L.; Rose, Kristie L.; Hammer, Neal D.; Skaar, Eric P.; Caprioli, Richard M.

    2015-01-01

    MALDI imaging mass spectrometry is a highly sensitive and selective tool used to visualize biomolecules in tissue. However, identification of detected proteins remains a difficult task. Indirect identifications strategies have been limited by insufficient mass accuracy to confidently link ion images to proteomics data. Here we demonstrate the capabilities of MALDI FTICR MS for imaging intact proteins. MALDI FTICR IMS provides an unprecedented combination of mass resolving power (∼75,000 at m/z 5,000) and accuracy (<5 ppm) for proteins up to ∼12 kDa enabling identification based on correlation with LC-MS/MS proteomics data. Analysis of rat brain tissue was performed as a proof-of-concept highlighting the capabilities of this approach by imaging and identifying a number of proteins including N-terminally acetylated Thymosin β4 (m/z 4,963.502, 0.6 ppm) and ATP Synthase subunit ε (m/z 5,636.074, −2.3 ppm). MALDI FTICR IMS was also used to differentiate a series of oxidation products of S100A8 (m/z 10,164.03, −2.1 ppm), a subunit of the heterodimer calprotectin, in kidney tissue from mice infected with Staphylococcus aureus. S100A8 – M37O/C42O3 (m/z 10228.00, −2.6 ppm) was found to co-localize with bactierial microcolonies at the center of infectious foci. The ability of MALDI FTICR IMS to distinguish S100A8 modifications is critical to understanding calprotectin’s roll in nutritional immunity. PMID:25904064

  13. MALDI FTICR IMS of Intact Proteins: Using Mass Accuracy to Link Protein Images with Proteomics Data

    NASA Astrophysics Data System (ADS)

    Spraggins, Jeffrey M.; Rizzo, David G.; Moore, Jessica L.; Rose, Kristie L.; Hammer, Neal D.; Skaar, Eric P.; Caprioli, Richard M.

    2015-06-01

    MALDI imaging mass spectrometry is a highly sensitive and selective tool used to visualize biomolecules in tissue. However, identification of detected proteins remains a difficult task. Indirect identification strategies have been limited by insufficient mass accuracy to confidently link ion images to proteomics data. Here, we demonstrate the capabilities of MALDI FTICR MS for imaging intact proteins. MALDI FTICR IMS provides an unprecedented combination of mass resolving power (~75,000 at m/z 5000) and accuracy (<5ppm) for proteins up to ~12kDa, enabling identification based on correlation with LC-MS/MS proteomics data. Analysis of rat brain tissue was performed as a proof-of-concept highlighting the capabilities of this approach by imaging and identifying a number of proteins including N-terminally acetylated thymosin β4 ( m/z 4,963.502, 0.6ppm) and ATP synthase subunit ɛ ( m/z 5,636.074, -2.3ppm). MALDI FTICR IMS was also used to differentiate a series of oxidation products of S100A8 ( m/z 10,164.03, -2.1ppm), a subunit of the heterodimer calprotectin, in kidney tissue from mice infected with Staphylococcus aureus. S100A8 - M37O/C42O3 ( m/z 10228.00, -2.6ppm) was found to co-localize with bacterial microcolonies at the center of infectious foci. The ability of MALDI FTICR IMS to distinguish S100A8 modifications is critical to understanding calprotectin's roll in nutritional immunity.

  14. Daily summary for IMS high-altitude satellites, days 1-181 1977

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A description of the orbital positions is provided for a number of high altitude satellites capable of making magnetospheric measurements in the first half of 1977 as part of the International Magnetospheric Study (IMS). Six artificial satellites -- Vela 5B, IMP-H, IMP-J, Solrad 11A, Solrad 11B, and Hawkeye 1 -- have been chosen along with the moon. The daily position summary of the satellites includes data tables which provide the crossing times of the bow shock and magnetopause, as well as the entry and exit times from the cusp, the high latitude tail, the midlatitude tail, and the neutral sheet region.

  15. The effects of CO2 on the negative reactant ions of IMS

    NASA Technical Reports Server (NTRS)

    Spangler, Glenn E.

    1995-01-01

    In the presence of CO2, the negative reactant ions of ion mobility spectrometry (IMS) are ion clusters of CO4(-) and CO3(-). Methyl salicylate is ionized by the CO4(-)(H2O(n))(N2(m)) reactant ions, but not by the CO3(-)(H2O(n))(N2(m)) reactant ions. While the CO4(-) ions are formed by direct association, the CO3(-) ions require additional energy to be formed. The additional energy is provided by either excited neutral gas molecules in a metastable state or UV (ultraviolet) radiation.

  16. IMS/Satellite Situation Center report. Predicted orbit plots for Vela 5B, 1976

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Predicted orbit plots for the Vela 5B satellite are presented for the time period January-December 1976. This satellite has been identified as an important possible contributor to the International Magnetospheric Study (IMS) project. The predicted orbit plots are shown in three projections. The time period covered by each set of projections is 4 days 16 hours, corresponding approximately to the period of Vela 5B. The three coordinate systems used are the Geocentric Solar Ecliptic system (GSE), the Geocentric Solar Magnetospheric system (GSM), and the Solar Magnetic system (SM).

  17. Complete genome sequence of a novel badnavirus, banana streak IM virus.

    PubMed

    Geering, Andrew D W; Parry, Judith N; Thomas, John E

    2011-04-01

    In 1999, banana streak disease outbreaks occurred at two locations in Australia in new banana hybrids that were being screened for fusarium wilt resistance. Two different badnaviruses, banana streak GF virus and a newly discovered virus called banana streak IM virus (BSIMV), were detected in these plants. The complete nucleotide sequence of the BSIMV genome was determined and comprised 7768 nt. Three open reading frames were detected, the first beginning with a non-conventional start codon (CUG). A 55-nt repetition in the putative pregenomic RNA promoter was also identified. Phylogenetic analysis suggests that BSIMV is most closely related to banana streak VN virus. PMID:21347843

  18. Layered and segmented system organization (LASSO) for highly reliable inventory monitoring systems (IMS)

    SciTech Connect

    Mangan, Dennis L.; Matter, John C.; Waddoups, I.; Abhold, M. E.; Chiaro, P.

    2002-01-01

    The Trilateral Initiative is preparing for International Atomic Energy Agency (LUiA) verification of excess fissile material released itom the defense programs of the United States and the Russian Federation. Following acceptance of the material using an Attribute Verification System, the IAEA will depend on an Inventory Monitoring System to maintain Continuity of Knowledge of the large inventory of thousands of items. Recovery fiom a total loss of Continuity of Knowledge in such a large storage facility would involve an extremely costly inventory re-verification This paper presents the framework for a Layered and Segmented System Organization that is the basis for a highly reliable IMS with protection-in-depth.

  19. Glycopeptide Site Heterogeneity and Structural Diversity Determined by Combined Lectin Affinity Chromatography/IMS/CID/MS Techniques

    NASA Astrophysics Data System (ADS)

    Zhu, Feifei; Trinidad, Jonathan C.; Clemmer, David E.

    2015-07-01

    Glycopeptides from a tryptic digest of chicken ovomucoid were enriched using a simplified lectin affinity chromatography (LAC) platform, and characterized by high-resolution mass spectrometry (MS) as well as ion mobility spectrometry (IMS)-MS. The LAC platform effectively enriched the glycoproteome, from which a total of 117 glycopeptides containing 27 glycan forms were identified for this protein. IMS-MS analysis revealed a high degree of glycopeptide site heterogeneity. Comparison of the IMS distributions of the glycopeptides from different charge states reveals that higher charge states allow more structures to be resolved. Presumably the repulsive interactions between charged sites lead to more open configurations, which are more readily separated compared with the more compact, lower charge state forms of the same groups of species. Combining IMS with collision induced dissociation (CID) made it possible to determine the presence of isomeric glycans and to reconstruct their IMS profiles. This study illustrates a workflow involving hybrid techniques for determining glycopeptide site heterogeneity and evaluating structural diversity of glycans and glycopeptides.

  20. Mindful Parenting Assessed Further: Psychometric Properties of the Dutch Version of the Interpersonal Mindfulness in Parenting Scale (IM-P).

    PubMed

    de Bruin, Esther I; Zijlstra, Bonne J H; Geurtzen, Naline; van Zundert, Rinka M P; van de Weijer-Bergsma, Eva; Hartman, Esther E; Nieuwesteeg, Anke M; Duncan, Larissa G; Bögels, Susan M

    2014-04-01

    Psychometric properties of the Dutch version of the Interpersonal Mindfulness in Parenting Scale (IM-P) were studied in a general population sample of mothers of adolescents (n=866) (study 1). A six-factor structure (29 items) emerged using exploratory factor analysis. A main difference from the original IM-P was that aspects of compassion and emotional awareness were separated into different factors for the self and the child, instead of combined into one factor. In a second general population sample of mothers of adolescents (n=.99), the six-factor structure was confirmed using confirmatory factor analysis (study 2). The proposed 29-item version of the IM-P and its subscales were shown to have good internal consistencies, apart from the sixth factor. As expected, a high correlation was found with general mindfulness questionnaires (FFMQ and FMI). Furthermore, the IM-P correlated positively as expected with quality of life and optimism and negatively with depression and dysfunctional parenting styles. These expected indications of construct validity were found in study 2, as well as in mothers (n=112) of adolescents with type 1 diabetes mellitus (study 3) which was added to examine whether the Dutch version of the IM-P was also valid in a pediatric population. Overall, these three studies present good psychometric properties of the Dutch translation of the first measure of mindful parenting. PMID:25126133

  1. Glycopeptide Site Heterogeneity and Structural Diversity Determined by Combined Lectin Affinity Chromatography/IMS/CID/MS Techniques.

    PubMed

    Zhu, Feifei; Trinidad, Jonathan C; Clemmer, David E

    2015-07-01

    Glycopeptides from a tryptic digest of chicken ovomucoid were enriched using a simplified lectin affinity chromatography (LAC) platform, and characterized by high-resolution mass spectrometry (MS) as well as ion mobility spectrometry (IMS)-MS. The LAC platform effectively enriched the glycoproteome, from which a total of 117 glycopeptides containing 27 glycan forms were identified for this protein. IMS-MS analysis revealed a high degree of glycopeptide site heterogeneity. Comparison of the IMS distributions of the glycopeptides from different charge states reveals that higher charge states allow more structures to be resolved. Presumably the repulsive interactions between charged sites lead to more open configurations, which are more readily separated compared with the more compact, lower charge state forms of the same groups of species. Combining IMS with collision induced dissociation (CID) made it possible to determine the presence of isomeric glycans and to reconstruct their IMS profiles. This study illustrates a workflow involving hybrid techniques for determining glycopeptide site heterogeneity and evaluating structural diversity of glycans and glycopeptides. PMID:25840811

  2. An IMS-Based Middleware Solution for Energy-Efficient and Cost-Effective Mobile Multimedia Services

    NASA Astrophysics Data System (ADS)

    Bellavista, Paolo; Corradi, Antonio; Foschini, Luca

    Mobile multimedia services have recently become of extreme industrial relevance due to the advances in both wireless client devices and multimedia communications. That has motivated important standardization efforts, such as the IP Multimedia Subsystem (IMS) to support session control, mobility, and interoperability in all-IP next generation networks. Notwithstanding the central role of IMS in novel mobile multimedia, the potential of IMS-based service composition for the development of new classes of ready-to-use, energy-efficient, and cost-effective services is still widely unexplored. The paper proposes an original solution for the dynamic and standard-compliant redirection of incoming voice calls towards WiFi-equipped smart phones. The primary design guideline is to reduce energy consumption and service costs for the final user by automatically switching from the 3G to the WiFi infrastructure whenever possible. The proposal is fully compliant with the IMS standard and exploits the recently released IMS presence service to update device location and current communication opportunities. The reported experimental results point out that our solution, in a simple way and with full compliance with state-of-the-art industrially-accepted standards, can significantly increase battery lifetime without negative effects on call initiation delay.

  3. Contributions a l'etude des lidars a champs visuels multiples

    NASA Astrophysics Data System (ADS)

    Roy, Gilles

    On presente un modele, base sur la diffraction et l'optique geometrique, liant les signaux lidar a champs multiples a la densite de distribution de la taille des particules. On ecrit la relation sous forme matricielle ce qui permet d'obtenir la densite de distribution apparente de la taille des particules par inversion matricielle avec contrainte. On interprete la perturbation causee par la contribution de l'optique geometrique au signal lidar comme de la diffraction causee par une particule de diametre d'environ un micron. La densite de distribution apparente est corrigee a posteriori en calculant la contribution relative des differents ordres de diffusion a l'elargissement de la fonction de phase des particules. La validite du modele est supportee par des simulations Monte Carlo et par des resultats experimentaux obtenus sous des conditions controlees. Finalement, on applique avec succes, la technique d'inversion aux mesures lidar multichamps obtenues sur des nuages.

  4. Synthesis, characterization, DNA-binding and cytotoxic properties of Ru(II) complexes: [Ru(MeIm)4L]2+ (MeIm = 1-methylimidazole, L = phen, ip and pip)

    NASA Astrophysics Data System (ADS)

    Zeng, Leli; Xiao, Yue; Liu, Jing; Tan, Lifeng

    2012-07-01

    Three new ruthenium(II) complexes, [Ru(MeIm)4phen]2+ (1), [Ru(MeIm)4ip]2+ (2) and [Ru(MeIm)4pip]2+ (3), have been synthesized and characterized. The binding properties of the three complexes towards calf-thymus DNA were investigated by different spectrophotometric methods and viscosity measurements. In addition, the cytotoxicity of these complexes has been evaluated by MTT method and Giemsa staining experiment. The main results reveal that the plane area and hydrophobicity of intercalative ligands have a significant effect on the DNA-binding behaviors and the IC50 value of complex 2 against MCF-7 cells is close to that of cis-Pt(NH3)2Cl2.

  5. Regles de fusion en theorie des champs conformes

    NASA Astrophysics Data System (ADS)

    Begin, Luc

    1999-10-01

    Les théories de champs conformes constituent un domaine de recherche très actif avec de nombreuses applications en physique statistique, en matière condensée, en théorie des cordes, en mathématiques, etc. Nous analysons ici le calcul des règles de fusion dans les modèles Wess- Zumino-Witten par des méthodes positives. Les règles de fusion sont des quantités importantes puisqu'elles indiquent comment se combinent les champs primaires de la théorie. L'approche présentée est basée sur l'hypothèse que les règles de fusion sont décrites par un système d'inéquations linéaire et homogène et mène au concept original de «base de fusion». Cette approche simple et générale permet d'utiliser les méthodes combinatoires et de programmation linéaire pour construire les fonctions génératrices et les bases de fusion. Cette méthode permet d'obtenir des résultats originaux et explicites pour les algèbres su (3), su (4) et sp (4).

  6. Problemes en enseignement fonctionnel des langues (Problems in the Functional Teaching of Languages). Publication B-103.

    ERIC Educational Resources Information Center

    Alvarez, Gerardo, Ed.; Huot, Diane, Ed.

    Articles include: (1) "L'elaboration du materiel pedagogique pour des publics adultes" (The Elaboration of Teaching Materials for the Adult Public) by G. Painchaud-Leblanc, (2) "L'elaboration d'un programme d'etudes en francais langue seconde a partir des donnees recentes en didactique des langues" (The Elaboration of a Program of Study in French…

  7. The Development of Cockpit Display and Alerting Concepts for Interval Management (IM) in a Near-Term Environment

    NASA Technical Reports Server (NTRS)

    Baxley, Brian T.; Shay, Richard F.; Swieringa, Kurt A.

    2014-01-01

    The National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC) Interval Management (IM) research team has conducted a wide spectrum of work in the recent past, ranging from development and testing of the concept, procedures, and algorithm. This document focuses on the research and evaluation of the IM pilot interfaces, cockpit displays, indications, and alerting concepts for conducting IM spacing operations. The research team incorporated knowledge of human factors research, industry standards for cockpit design, and cockpit design philosophies to develop innovative displays for conducting these spacing operations. The research team also conducted a series of human-in-the-loop (HITL) experiments with commercial pilots and air traffic controllers, in as realistic a high-density arrival operation environment as could be simulated, to evaluate the spacing guidance display features and interface requirements needed to conduct spacing operations.

  8. Cd(ii)-MOF-IM: post-synthesis functionalization of a Cd(ii)-MOF as a triphase transfer catalyst.

    PubMed

    Wang, Jian-Cheng; Ma, Jian-Ping; Liu, Qi-Kui; Hu, Yu-Hong; Dong, Yu-Bin

    2016-05-19

    A robust and porous Cd(ii)-MOF based on a bent imidazole-bridged ligand was synthesized and post-synthetically functionalized with linear alkyl chains to afford imidazolium salt (IM)-type triphase transfer catalysts for organic transformations. The imidazolium salt decorated Cd(ii)-MOF-IM exhibits typical solid phase transfer catalytic behavior for the azidation and thiolation of bromoalkane between aqueous/organic phases. Moreover, they can be easily recovered and reused under the PTC conditions. Cd(ii)-MOF-IM herein created a versatile family of solid phase transfer catalysts for promoting a broad scope of reactions carried out in a biphasic mixture of two immiscible solvents. PMID:27039710

  9. VLBI FOR GRAVITY PROBE B. VII. THE EVOLUTION OF THE RADIO STRUCTURE OF IM PEGASI

    SciTech Connect

    Bietenholz, M. F.; Bartel, N.; Ransom, R. R.; Lebach, D. E.; Ratner, M. I.; Shapiro, I. I.

    2012-07-01

    We present measurements of the total radio flux density as well as very long baseline interferometry images of the star, IM Pegasi, which was used as the guide star for the NASA/Stanford relativity mission Gravity Probe B. We obtained flux densities and images from 35 sessions of observations at 8.4 GHz ({lambda} = 3.6 cm) between 1997 January and 2005 July. The observations were accurately phase-referenced to several extragalactic reference sources, and we present the images in a star-centered frame, aligned by the position of the star as derived from our fits to its orbital motion, parallax, and proper motion. Both the flux density and the morphology of IM Peg are variable. For most sessions, the emission region has a single-peaked structure, but 25% of the time, we observed a two-peaked (and on one occasion perhaps a three-peaked) structure. On average, the emission region is elongated by 1.4 {+-} 0.4 mas (FWHM), with the average direction of elongation being close to that of the sky projection of the orbit normal. The average length of the emission region is approximately equal to the diameter of the primary star. No significant correlation with the orbital phase is found for either the flux density or the direction of elongation, and no preference for any particular longitude on the star is shown by the emission region.

  10. Lipozyme TL IM as Catalyst for the Synthesis of Eugenyl Acetate in Solvent-Free Acetylation.

    PubMed

    Silva, María José A; Loss, Raquel A; Laroque, Denise A; Lerin, Lindomar A; Pereira, Gabriela N; Thon, Élise; Oliveira, J Vladimir; Ninow, Jorge L; Hense, Haiko; Oliveira, Débora

    2015-06-01

    The ability of commercial immobilized lipase from Thermomyces lanuginosus (Lipozyme TL IM) to catalyze the acetylation of essential clove oil with acetic anhydride in a solvent-free system was studied, and the antimicrobial activity of the ester formed was evaluated as well. Experimental design based on two variables (eugenol to acetic anhydride molar ratio and temperature) was employed to evaluate the experimental conditions of eugenyl acetate ester production. The maximum conversion yield (92.86 %) was obtained using Lipozyme TL IM (5 wt%, based on the total amount of substrates), with eugenol to acetic anhydride molar ratio of 1:5 at 70 °C. The chemical structure of the eugenyl acetate ester obtained at the optimized condition, and purified, was confirmed by the proton nuclear magnetic resonance ((1)H-NMR) analysis. The antimicrobial activity of eugenyl acetate ester was proven effective on Gram-positive and Gram-negative bacteria, with means of 16.62 and 17.55 mm of inhibition halo. PMID:25875787

  11. Signal Processing for Indian and Pakistan Nuclear Tests Recorded at IMS Stations Located in Israel

    NASA Astrophysics Data System (ADS)

    Gitterman, Y.; Pinsky, V.; Hofstetter, R.

    - In compliance with the Comprehensive Nuclear-Test-Ban-Treaty (CTBT) the International Monitoring System (IMS) was designed for detection and location of the clandestine Nuclear Tests (NT). Two auxiliary IMS seismic stations MRNI and EIL, deployed recently, were subjected to detectability, travel-time calibration and discrimination analysis. The study is based on the three recent 1998 underground nuclear explosions: one of India and two of Pakistan, which provided a ground-truth test of the existing IMS. These events, attaining magnitudes of 5.2, 4.8 and 4.6 correspondingly, were registered by many IMS and other seismic stations.The MRNI and EIL broadband (BB) stations are located in Israel at teleseismic distances (from the explosions) of 3600, 2800 and 2700km, respectively, where the signals from the tests are already weak. The Indian and the second Pakistan NT were not detected by the short-period Israel Seismic Network (ISN), using standard STA/LTA triggering. Therefore, for the chosen IMS stations we compare the STA/LTA response to the results of the more sensitive Murdock-Hutt (MH) and the Adaptive Statistically Optimal Detector (OD) that showed triggering for these three events. The second Pakistan NT signal arrived at the ISN and the IMS stations in the coda of a strong Afghanistan earthquake and was further disturbed by a preceding signal from a local earthquake. However, the NT signal was successfully extracted at EIL and MRNI stations using MH and OD procedures. For comparison we provide the signal analysis of the cooperating BB station JER, with considerably worse noise conditions than EIL and MRNI, and show that OD can detect events when the other algorithms fail. Using the most quiet EIL station, the most sensitive OD and different bandpass filters we tried in addition to detect the small Kazakh chemical 100-ton calibration explosion of 1998, with magnitude 3.7 at a distance approaching 4000km. The detector response curve showed uprising in the

  12. A Helium GC/IMS for the Analysis of Extraterrestrial Volatiles in Exobiology Flight Experiments

    NASA Technical Reports Server (NTRS)

    Kojiro, Daniel R.; Carle, Glenn C.; Humphry, Donald E.; Shao, Maxine; Takeuchi, Nori

    1995-01-01

    For exobiology experiments on board spacecraft or space probes, a wide range of chemical species often must be detected and identified. The limited amount of power and space available for flight instruments severely limits the number of instruments that can be flown on any given mission. It is important then, that these experiments utilize instrumentation with universal response, so that all species of interest can be analyzed. Instrumentation to fulfill the analytical requirements of exobiology experiments has been developed utilizing Gas Chromatography - Ion Mobility Spectrometry. The Gas Chromatograph (GC) combines columns developed specifically for the complex mixtures anticipated with highly sensitive Metastable Ionization Detectors (a type of Helium Ionization Detector). To satisfy the limitations placed on resources, the Ion Mobility Spectrometer (IMS) uses the same ultra high purity helium as the GC. This GC-MS provides the analytical capability to fulfill a wide range of exobiology flight experiment applications and has been included on a proposed Discovery Mission and proposals for both Lander and Orbiter of the European Space Agency's Rosetta Comet Mission. A data base of helium IMS spectra is now being built for these future applications.

  13. Positive corona discharge ion source with IMS/MS to detect impurities in high purity Nitrogen

    NASA Astrophysics Data System (ADS)

    Sabo, M.; Klas, M.; Wang, H.; Huang, C.; Chu, Y.; Matejčík, Š.

    2011-07-01

    We have applied the Ion Mobility Spectrometry/Mass Spectrometry (IMS/MS) and the Atmospheric Pressure Chemical Ionisation/Mass Spectrometry (APCI/MS) techniques to study the formation of the ions in the positive corona discharge (CD) in highly purified nitrogen with impurities at 100 ppt level. The main products observed were H3O+(H2O)n ions (reduced ion mobility of 2.15 cm2 V-1 s-1). Additionally, we have observed ions with reduced mobilities 2.42 cm2 V-1 s-1 and 2.30 cm2 V-1 s-1. The intensity of these ions was increasing with the increasing discharge current. We associated these peaks with NH4+ and NO+(H2O)n. The formation of these ions results from trace amounts of O2 and NH3 in nitrogen. The time evolution of the ions in corona discharge has been studied using the APCI/MS technique in the time windows ranging from 100 μs to 2 ms. The present work indicates the ability of the IMS technique equipped with CD ions source to detect impurities below 100 ppt level.

  14. Creating High-Resolution Maps of Leaf Water Isotopes Using IM-CRDS and IRMS Techniques

    NASA Astrophysics Data System (ADS)

    Gerlein-Safdi, C.; Sinkler, C. J.; Caylor, K. K.

    2014-12-01

    Since the development of isotope ratio infrared spectroscopy (IRIS), the applications of water isotope analysis have been increasing. Here, we present a new protocol to create high-resolution maps of leaf water isotopes 18O and 2H. We use the Picarro induction module (IM-CRDS) combined with an isotope analyzer (L2130-i) to sample up to 25 locations in one half of each leaf. Each sampling location corresponds to four samples (6 mm outside diameter punched-holes) punched next to each other. In the induction module, an induction coil heats a metal holder containing the leaf sample. The sample will release water vapor that is then sent to the isotope analyzer. The IM-CRDS allows us to significantly reduce the sample size and therefore increase the sample density, compared to the traditional cryogenic extraction method. Using spatial analysis tools, we create high-resolution spatial maps of each isotope as well as d-excess maps. The water in the second half of the leaf is extracted by cryogenic extraction and analyzed using both IRIS and isotope ratio mass spectroscopy. The isotopic composition of the extracted water is compared to the average composition calculated from the maps and used for calibration. We present applications of this protocol to the analysis of the spatio-temporal evolution of foliar uptake in Colocasia esculenta under laboratory conditions.

  15. IM-TORNADO: A Tool for Comparison of 16S Reads from Paired-End Libraries

    PubMed Central

    Jeraldo, Patricio; Kalari, Krishna; Chen, Xianfeng; Bhavsar, Jaysheel; Mangalam, Ashutosh; White, Bryan; Nelson, Heidi; Kocher, Jean-Pierre; Chia, Nicholas

    2014-01-01

    Motivation 16S rDNA hypervariable tag sequencing has become the de facto method for accessing microbial diversity. Illumina paired-end sequencing, which produces two separate reads for each DNA fragment, has become the platform of choice for this application. However, when the two reads do not overlap, existing computational pipelines analyze data from read separately and underutilize the information contained in the paired-end reads. Results We created a workflow known as Illinois Mayo Taxon Organization from RNA Dataset Operations (IM-TORNADO) for processing non-overlapping reads while retaining maximal information content. Using synthetic mock datasets, we show that the use of both reads produced answers with greater correlation to those from full length 16S rDNA when looking at taxonomy, phylogeny, and beta-diversity. Availability and Implementation IM-TORNADO is freely available at http://sourceforge.net/projects/imtornado and produces BIOM format output for cross compatibility with other pipelines such as QIIME, mothur, and phyloseq. PMID:25506826

  16. ImTK: an open source multi-center information management toolkit

    NASA Astrophysics Data System (ADS)

    Alaoui, Adil; Ingeholm, Mary Lou; Padh, Shilpa; Dorobantu, Mihai; Desai, Mihir; Cleary, Kevin; Mun, Seong K.

    2008-03-01

    The Information Management Toolkit (ImTK) Consortium is an open source initiative to develop robust, freely available tools related to the information management needs of basic, clinical, and translational research. An open source framework and agile programming methodology can enable distributed software development while an open architecture will encourage interoperability across different environments. The ISIS Center has conceptualized a prototype data sharing network that simulates a multi-center environment based on a federated data access model. This model includes the development of software tools to enable efficient exchange, sharing, management, and analysis of multimedia medical information such as clinical information, images, and bioinformatics data from multiple data sources. The envisioned ImTK data environment will include an open architecture and data model implementation that complies with existing standards such as Digital Imaging and Communications (DICOM), Health Level 7 (HL7), and the technical framework and workflow defined by the Integrating the Healthcare Enterprise (IHE) Information Technology Infrastructure initiative, mainly the Cross Enterprise Document Sharing (XDS) specifications.

  17. 'I'm really glad this is developmental': autism and social comparisons - an interpretative phenomenological analysis.

    PubMed

    Huws, Jaci C; Jones, Robert S P

    2015-01-01

    The present qualitative study comprised interviews with nine young people with autism (aged 16-21 years) about their perceptions of autism. Using interpretative phenomenological analysis, three underlying themes were illuminated, and all these formed the superordinate theme Making Comparisons: (a) Changes over time: 'I'm really glad this is developmental'; (b) Degrees of autism: 'They've got it really bad'; and (c) Degrees of ability: 'I'm not really disabled-disabled'. Such comparisons were not explicitly sought at the outset of the study, and instead emerged from their conceptualisations of the autism concept. When comparing how they perceived themselves now, and how they perceived themselves in the past, the young people viewed themselves more positively in the present. In addition, when making comparisons with other people with autism, they tended to locate themselves as being in a better position than others were. The perspective of being in a more fortunate position because of heightened abilities also emerged from the comparisons made with people who did not have autism. Furthermore, similar comparisons were made when autism was compared to disability, with autism being evaluated as being more favourable than what was termed 'proper' disability. The results of this study are discussed in relation to the existent social comparison literature. PMID:24335114

  18. The mini-CIDEX GC/IMS: Analysis of cometary ice and dust

    NASA Technical Reports Server (NTRS)

    Kojiro, Daniel R.; Carle, Glenn C.; Humphry, Donald E.; Shao, Maxine; Takeuchi, Nori

    1995-01-01

    Comets are recognized as among the most scientifically important objects in the solar system. They are presumed relics of the early primitive material in the solar nebula and are believed to have provided a general enrichment of volatiles to the inner solar system. The Cometary Coma Chemical Composition (C4) Mission, a proposed Discovery-Class Mission, will analyze materials released into the coma, providing information leading to the understanding of the chemical composition and make-up of the cometary nucleus. As one of two scientific instruments in the C4 spacecraft, an advanced and streamlined version of the Cometary Ice and Dust Experiment (CIDEX), a mini-CIDEX, will employ an X-Ray Fluorescence (XRF) spectrometer to determine bulk elemental composition of cometary dust grains and a Gas Chromatograph/Ion Mobility Spectrometer (GC/IMS) for determination of the molecular composition of dust and ices following stepwise pyrolysis and combustion. A description of the mini-CIDEX IMS will be provided as well as data from analyses conducted using the mini-CIDEX breadboard instrument.

  19. Contamination monitoring for ammonia, amines, and acid gases utilizing ion mobility spectroscopy (IMS)

    NASA Astrophysics Data System (ADS)

    Bacon, Tad; Webber, Kurt; Carpio, Ronald A.

    1998-06-01

    The effect of ammonia (NH3) and n-methyl pyrrolidinone (NMP) contamination on chemically amplified DUV resists is well documented. Other amines and related compounds are under suspicion as well. In addition, the concentration levels that are of concern have steadily decreased from approximately 10 ppbv down to levels as low as 0.1 ppbv. While some techniques such as ion chromotagraphy (IC) have been demonstrated to have limits of detection at these levels, the analysis times are rather long and cumbersome. This paper describes the use of IMS to perform these measurements, in a totally automated, continuous instrument. IMS is a simplified time-of-flight technique that requires no liquid reagents and has been demonstrated to be a reliable method for monitoring for ammonia and NMP in cleanrooms. This paper demonstrates the ability of the technique to monitor for amines such as dimethylamine, methylamine, methanolamine, ethanolamine, diethanolamine, butylamine and others. Detection limits of 0.1 ppbv and below are clearly demonstrated. Also discussed are methods of monitoring multiple points with a single analyzer. Ability to detect corrosive gases such as hydrogen fluoride (HF), hydrogen chloride (HCl), sulfur dioxide (SO2), sulfur trioxide (SO3), nitrogen dioxide (NO2), chlorine (Cl2), bromine (Br2), phosphoric acid (H3PO4) are also demonstrated.

  20. Activity of a Py-Im Polyamide Targeted to the Estrogen Response Element

    PubMed Central

    Nickols, Nicholas G.; Szablowski, Jerzy O.; Hargrove, Amanda E.; Li, Benjamin C.; Raskatov, Jevgenij A.; Dervan, Peter B.

    2013-01-01

    Pyrrole-imidazole (Py-Im) polyamides are a class of programmable DNA minor groove binders capable of modulating the activity of DNA-binding proteins and affecting changes in gene expression. Estrogen Receptor Alpha (ERα) is a ligand-activated hormone receptor that binds as a homodimer to estrogen response elements (EREs) and is a driving oncogene in a majority of breast cancers. We tested a selection of structurally similar Py-Im polyamides with differing DNA sequence specificity for activity against 17β-estadiol (E2) induced transcription and cytotoxicity in ERα positive, E2 stimulated T47D-KBLUC cells, which express luciferase under ERα control. The most active polyamide targeted the sequence: 5’-WGGWCW-3’ (W = A or T), which is the canonical ERE-half site. Whole transcriptome analysis using RNA-Seq revealed that treatment of E2-stimulated breast cancer cells with this polyamide reduced the effects of E2 on the majority of those most strongly affected by E2, but had much less effect on the majority of E2 induced transcripts. In vivo, this polyamide circulated at detectable levels following subcutaneous injection and reduced levels of ER-driven luciferase expression in xenografted tumors in mice after subcutaneous compound administration without significant host toxicity. PMID:23443804

  1. Functional analyses of cotton (Gossypium hirsutum L.) immature fiber (im) mutant infer that fiber cell wall development is associated with stress responses

    PubMed Central

    2013-01-01

    Background Cotton fiber maturity is an important factor for determining the commercial value of cotton. How fiber cell wall development affects fiber maturity is not well understood. A comparison of fiber cross-sections showed that an immature fiber (im) mutant had lower fiber maturity than its near isogenic wild type, Texas marker-1 (TM-1). The availability of the im mutant and TM-1 provides a unique way to determine molecular mechanisms regulating cotton fiber maturity. Results Transcriptome analysis showed that the differentially expressed genes (DEGs) in the im mutant fibers grown under normal stress conditions were similar to those in wild type cotton fibers grown under severe stress conditions. The majority of these DEGs in the im mutant were related to stress responses and cellular respiration. Stress is known to reduce the activity of a classical respiration pathway responsible for energy production and reactive oxygen species (ROS) accumulation. Both energy productions and ROS levels in the im mutant fibers are expected to be reduced if the im mutant is associated with stress responses. In accord with the prediction, the transcriptome profiles of the im mutant showed the same alteration of transcriptional regulation that happened in energy deprived plants in which expressions of genes associated with cell growth processes were reduced whereas expressions of genes associated with recycling and transporting processes were elevated. We confirmed that ROS production in developing fibers from the im mutant was lower than that from the wild type. The lower production of ROS in the im mutant fibers might result from the elevated levels of alternative respiration induced by stress. Conclusion The low degree of fiber cell wall thickness of the im mutant fibers is associated with deregulation of the genes involved in stress responses and cellular respiration. The reduction of ROS levels and up-regulation of the genes involved in alternative respirations suggest that

  2. Promoters of the CATG-Specific Methyltransferase Gene hpyIM Differ between iceA1 and iceA2 Helicobacter pylori Strains

    PubMed Central

    Xu, Qing; Blaser, Martin J.

    2001-01-01

    Helicobacter pylori strains can be divided into two groups, based on the presence of two unrelated genes, iceA1 and iceA2, that occupy the same genomic locus. hpyIM, located immediately downstream of either gene, encodes a functional CATG-specific methyltransferase. Despite the strong conservation of the hpyIM open reading frame (ORF) among all H. pylori strains, the sequences upstream of the ORF in iceA1 and iceA2 strains are substantially different. To explore the roles of these upstream sequences in hpyIM regulation, promoter analysis of hpyIM was performed. Both deletion mutation and primer extension analyses demonstrate that the hpyIM promoters differ between H. pylori strains 60190 (iceA1) and J188 (iceA2). In strain 60190, hpyIM has two promoters, Pa or PI, which may function independently, whereas only one hpyIM promoter, Pc, was found in strain J188. The XylE assay showed that the hpyIM transcription level was much higher in strain 60190 than in strain J188, indicating that regulation of hpyIM transcription differs between the H. pylori iceA1 strain (60190) and iceA2 strains (J188). Since the iceA1 and iceA2 sequences are highly conserved within iceA1 or iceA2 strains, we conclude that promoters of the CATG-specific methylase gene hpyIM differ between iceA1 and iceA2 strains, which leads to differences in regulation of hpyIM transcription. PMID:11395450

  3. [And Sarah Félix created "L 'Eau des Fées" and "La Parfumerie des Fées"].

    PubMed

    Raynal, Cécile

    2015-12-01

    century, the parisian perfumery of Sarah Felix was famous especially for her cosmetic "L'Eau des Fées" ("Water of the Fairies"), a dyeing supposed to give back to the old hair the color of their youth. Sarah Felix, sister of the famous actress Rachel, exercised several jobs before becoming perfumer. At first, she was actress, then she tried ... oyster culture in Normandy ! Abandoning these activities, Sarah Felix became really a businesswoman in Paris. She dedicated herself to perfumery, in particular to "L'Eau des Fées", from 1866. To launch its product, she was associated to competency characters (engineer, pharmacist, physician) and benefited from the protection of the imperial family. A lawsuit between the associates and the 1870 war hindered the company's early days, but "L'Eau des Fées" provided with quality pledges, imposed itself definitely. The "Parfumerie des Fées" completed the range of its cosmetics with creams, powders, etc. Sarah Félix paid attention to present "L'Eau des Fées" as a dye devoid of toxicity. Was it really the case and could il be sold nowadays? These two issues are discussed in the last part. PMID:26827551

  4. Spectroscopic confirmation of DES12S2a

    NASA Astrophysics Data System (ADS)

    Brown, P. J.; Krisciunas, K.; Marshall, J.; Suntzeff, N.; Ahn, E.; Finley, D.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Bloom, J. S.; Kim, A.; Nugent, P.; Perlmutter, S.; Thomas, R. C.; Desai, S.; Paech, K.; Smith, R. C.; Kessler, R.; Covarrubias, R. A.; Cane, R.; Fischer, J. A.; Gilhool, S.; Gladney, L.; Gupta, R.; Mosher, J.; Sako, M.; Campbell, H.; D'Andrea, C.; Nichol, R.; Papadopoulos, A.; Sullivan, M.; March, M.; Smith, M.; Barbary, K.; Bernstein, J. P.; Biswas, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.

    2013-02-01

    We report optical spectroscopy of a supernova (SN) candidate discovered by the Dark Energy Supernova Survey (ATel #4668). The spectrum (450-1000 nm) of DES12S2a was obtained with the 9.2-m Hobby-Eberly Telescope (+Marcario Low-Resolution Spectrograph) by J. Caldwell. The spectrum shows a blue continuum with a narrow H-alpha emission feature atop a broader component indicative of a type IIn SN. The phase at the date of the spectrum given below is based on the DES light curves.

  5. Comparison des donnees simulees des capteurs de SPOT et landsat-D: Application a une region agricole

    NASA Astrophysics Data System (ADS)

    Saint, Gilbert; Podaire, Alain

    La modélisation de la luminance spectrale des objets observés en télédétection permet d'effectuer des simulations de différents capteurs à partir de données obtenues au moyen d'un scanneur DAEDALUS aéroporté : les qualités radiométrique et géométrique ont pu être évaluées par une comparaison avec des données Landsat réelles. L'analyse sur une zone agricole met surtout en évidence le rôle important de l'accroissement de la résolution.

  6. Analyse des facteurs prédictifs de malignité des goitres nodulaires : à propos de 500 cas

    PubMed Central

    Bouaity, Brahim; Darouassi, Youssef; Chihani, Mehdi; Touati, Mohamed Mliha; Ammar, Haddou

    2016-01-01

    Les nodules thyroïdiens sont très fréquents et moins de 10% d'entre eux sont malin. Ils posent un véritable problème diagnostique et thérapeutique surtout par rapport à leur nature bénigne ou maligne. L’étude de certains facteurs cliniques et paracliniques de présomption de malignité permet de bien codifier la stratégie thérapeutique. Le but de ce travail est d’étudier les facteurs prédictifs de malignité des goitres nodulaires et comparer nos résultats à ceux de la littérature. Il s'agit d'une étude rétrospective à propos de 500 cas de goitres nodulaires opérés au service d'Oto-rhino-laryngologie (ORL) et Chirurgie cervico-faciale (CCF) de l'hôpital militaire Avicenne de Marrakech entre 2006 et 2012. Le pourcentage de cancers a été de 6,8%. L’âge moyen de nos patients était de 46 ans, avec une sex-ratio de 5 (F/H). A la palpation cervicale; le caractère dure du nodule a été constaté dans 94,4% des cas de cancer, avec des limites irrégulières dans 64,70% des cas de cancer. Trois nodules étaient fixes et ils étaient tous malins. Les adénopathies cervicales ont été constatées chez 8 malades dont 7 présentaient des cancers. A l’échographie, 61,8% des nodules malins présentaient un aspect hypoéchogène, avec des contours flous dans 88,24% des cas. La vascularisation intra nodulaire était présente dans 35,3% de ces cas des cancers avec des microcalcifications chez 55,9% d'entre eux. Le halo hypoéchogene périnodulaire était incomplet dans 73,5% des cas de cancer. Nos patients étaient en euthyroïdie dans 84,6% des cas. Les facteurs prédictifs de malignité d'un goitre nodulaire, étaient donc dans notre étude d'abord cliniques: l’âge supérieur à 60 ans, la consistance dure du nodule, sa fixité, son caractère irrégulier et mal limité à la palpation, ainsi que la présence d'adénopathie(s) cervicale(s) à l'examen; et échographiques: le caractère hypoéchogène, les limites floues, la présence de

  7. Phase I Randomized Clinical Trial of VRC DNA and rAd5 HIV-1 Vaccine Delivery by Intramuscular (IM), Subcutaneous (SC) and Intradermal (ID) Administration (VRC 011)

    PubMed Central

    Enama, Mary E.; Ledgerwood, Julie E.; Novik, Laura; Nason, Martha C.; Gordon, Ingelise J.; Holman, LaSonji; Bailer, Robert T.; Roederer, Mario; Koup, Richard A.; Mascola, John R.; Nabel, Gary J.; Graham, Barney S.

    2014-01-01

    Background Phase 1 evaluation of the VRC HIV DNA and rAd5 vaccines delivered intramuscularly (IM) supported proceeding to a Phase 2 b efficacy study. Here we report comparison of the IM, subcutaneous (SC) and intradermal (ID) routes of administration. Methods Sixty subjects were randomized to 6 schedules to evaluate the IM, SC or ID route for prime injections. Three schedules included DNA primes (Wks 0,4,8) and 3 schedules included rAd5 prime (Wk0); all included rAd5 IM boost (Wk24). DNA vaccine dosage was 4 mg IM or SC, but 0.4 mg ID, while all rAd5 vaccinations were 1010 PU. All injections were administered by needle and syringe. Results Overall, 27/30 subjects completed 3 DNA primes; 30/30 subjects completed rAd5 primes. Mild local pruritus (itchiness), superficial skin lesions and injection site nodules were associated with ID and SC, but not IM injections. All routes induced T-cell and antibody immune responses after rAd5 boosting. Overall, >95% had Env antibody and >80% had Env T-cell responses. Conclusions The pattern of local reactogenicity following ID and SC injections differed from IM injections but all routes were well-tolerated. There was no evidence of an immunogenicity advantage following SC or ID delivery, supporting IM delivery as the preferred route of administration. Trial Registration Clinicaltrials.gov NCT00321061 PMID:24621858

  8. Transport de paires EPR dans des structures mesoscopiques

    NASA Astrophysics Data System (ADS)

    Dupont, Emilie

    Dans cette these, nous nous sommes particulierement interesses a la propagation de paires EPR1 delocalisees et localisees, et a l'influence d'un supraconducteur sur le transport de ces paires. Apres une introduction de cette etude, ainsi que du cadre scientifique qu'est l'informatique quantique dans lequel elle s'inscrit, nous allons dans le chapitre 1 faire un rappel sur le systeme constitue de deux points quantiques normaux entoures de deux fils supraconducteurs. Cela nous permettra d'introduire une methode de calcul qui sera reutilisee par la suite, et de trouver egalement le courant Josephson produit par ce systeme transforme en SQUID-dc par l'ajout d'une jonction auxiliaire. Le SQUID permet de mesurer l'etat de spin (singulet ou triplet), et peut etre forme a partir d'autres systemes que nous etudierons ensuite. Dans le chapitre 2, nous rappellerons l'etude detaillee d'un intricateur d'Andreev faite par un groupe de Bale. La matrice T, permettant d'obtenir le courant dans les cas ou les electrons sont separes spatialement ou non, sera etudiee en detail afin d'en faire usage au chapitre suivant. Le chapitre 3 est consacre a l'etude de l'influence du bruit sur le fonctionnement de l'intricateur d'Andreev. Ce bruit modifie la forme du courant jusqu'a aboutir a d'autres conditions de fonctionnement de l'intricateur. En effet, le bruit present sur les points quantiques peut perturber le transport des paires EPR par l'intermediaire des degres de liberte. Nous montrerons que, du fait de l'"intrication" entre la charge de la paire et le bruit, la paire est detruite pour des temps longs. Cependant, le resultat le plus important sera que le bruit perturbe plus le transport des paires delocalisees, qui implique une resonance de Breit-Wigner a deux particules. Le transport parasite n'implique pour sa part qu'une resonance de Breit-Wigner a une particule. Dans le chapitre 4, nous reviendrons au systeme constitue de deux points quantiques entoures de deux fils

  9. Symetries et integrabilite des equations aux differences finies

    NASA Astrophysics Data System (ADS)

    Lafortune, Stephane

    2000-09-01

    La présente thèse porte sur l'étude des symétries et des propriétés d'intégrabilité des équations aux différences finies. Dans le chapitre 1, le groupe de symétrie ponctuelle d'un système couplé à deux équations différentielles aux différences est étudié. On montre que dans certains cas, la dimension du groupe peut être infinie. Les équations peuvent décrire l'interaction de deux longues chaînes moléculaires, chacune étant composée d'atomes d'un même type. Dans le chapitre 2, une classe de théories de champs avec interaction exponentielle est introduite. L'interaction dépend de deux matrices de ``couplage'' et est suffisamment générale pour inclure toutes les théories de champs de Toda existant dans la littérature. Les symétries de Lie ponctuelles sont obtenues pour les cas où l'on a un nombre fini, infini ou semi-infini de champs. Une attention spéciale est accordée à la présence de l'invariance conforme. Dans le chapitre 3, nous procédons à la classification et à l'étude d'équations linéarisables. Nous examinons tout d'abord l'équation de Gambier continue qui contient, comme réductions, toutes les équations de deuxième ordre intégrables par linéarisation. Nous introduisons par la suite la forme discrète de cette équation et obtenons les conditions d'intégrabilité à l'aide du confinement des singularités. Nous étudions aussi les différentes réductions du cas discret. De plus, nous obtenons des transformations de Schlesinger pour les équations de Gambier discrète et continue. Dans la dernière partie du chapitre, nous étudions une famille d'équations discrètes du deuxième ordre incluant des équations résolubles par linéarisation. Plusieurs cas intégrables sont obtenus. Dans le cas discret, l'étude de l'intégrabilité est faite à l'aide du confinement des singularités. Dans le chapitre 4, nous étudions un autre critère d'intégrabilité: l'entropie algébrique. Nous montrons que les r

  10. Opération multimode transverse des OPOs: des structures classiques aux corrélations quantiques

    NASA Astrophysics Data System (ADS)

    Martinelli, M.; Ducci, S.; Gigan, S.; Treps, N.; Maître, A.; Fabre, C.

    2002-06-01

    Nous démontrons la formation de structures transverses sur les faisceaux émis par un oscillateur paramétrique optique (OPO) de type II en configuration confocale. D'un point de vue classique nous mettons en évidence le caractère multimode transverse de telles structures. A travers l'étude des corrélations spatiales des faisceaux générés nous montrons que ces structures sont également multimodes d'un point de vue quantique.

  11. Apport des moyens endoscopiques dans la dilatation des sténoses caustiques de l’œsophage

    PubMed Central

    Seydou, Togo; Abdoulaye, Ouattara Moussa; xing, Li; Zi, Sanogo Zimogo; sekou, Koumaré; Wen, Yang Shang; Ibrahim, Sankare; Sekou, Toure Cheik Ahmed; Boubacar, Maiga Ibrahim; Saye, Jacque; Jerome, Dakouo Dodino; Dantoumé, Toure Ousmane; Sadio, Yena

    2016-01-01

    Introduction Toutes les sténoses symptomatiques de l’œsophage peuvent être dilatées par voie endoscopique. Nous évaluons l'apport des moyens endoscopiques dans la prise en charge de la dilatation œsophagienne pour sténose caustique de l’œsophage (SCO) au Mali. Méthodes IL s'agissait d'une étude descriptive et prospective réalisée dans le service de chirurgie thoracique à l'hôpital du Mali. Au total 46 dossiers cliniques de patients on été enregistrés et subdivisés en 4 groupes en fonction de la topographie des lésions cicatricielles. Le nombre de cas d'assistance endoscopique réalisé a été déterminé afin de comprendre l'apport des moyens endoscopiques dans le succès de la dilatation des SCO. Pour les 2 différentes méthodes de dilatation utilisées, le résultat du traitement et le coût ont comparés. Résultats La FOGD a été utilisée dans 19 cas (41.30%) de dilatation avec la bougie de Savary Guillard et dans 47.82% des cas dans la dilatation de Lerut. La vidéo-laryngoscopie a été utilisé 58.69% des cas de dilatation à la bougie de Lerut. Le passage de guide métallique et / ou de fil-guide a été réalisée dans 39.13% avec la vidéo laryngoscopie et dans 58.68% avec la FOGD. Dans la comparaison des deux méthodes, il existe une différence significative dans la survenue des complications (p=0.04075), l'anesthésie générale (p=0.02287), l'accessibilité à la méthode (p=0.04805) et la mortalité (p=0.00402). Conclusion La SCO est une pathologie grave et sous évaluée au Mali. Les moyens endoscopiques contribuent considérablement au succès de la dilatation œsophagienne pour sténose caustique dans les différentes méthodes utilisées. PMID:27200129

  12. Régimes transitoires des photopiles: durée de vie des porteurs et vitesse de recombinaison

    NASA Astrophysics Data System (ADS)

    Mialhe, P.; Sissoko, G.; Pelanchon, F.; Salagnon, J. M.

    1992-12-01

    A detailed analysis of a new experimental practice of the open circuit voltage decay method and of the short circuit current decay method for determining the base minority carrier lifetime and the back surface recombination velocity in solar cells has been performed. The measurements have been made by using the monitoring of a single transient of an operating cell at any level of injection; no power supply is required and a constant illumination level imposes the carrier injection level for normal operating conditions. The theory considers the complete continuity equation including generation and recombination rates of carriers. Precision and sensitivity of the method have been compared. The necessity of a precise knowledge of cell structural parameters have been shown to impose a limitation of the practical use of short-circuit current decay method, to low illumination levels. Cette étude développe une nouvelle méthode expérimentale pour mesurer la durée de vie des porteurs minoritaires dans la base d'une photopile ainsi que la vitesse de recombinaison à son interface arrière. Au cours de la mesure, la photopile est maintenue sous un éclairement constant qui impose le niveau d'injection souhaité. Cette méthode permet d'éliminer les effets néfastes à la mesure, provenant des impédances, propres au composant. Un régime transitoire, provoqué par une variation d'impédance, est étudié au cours de fonctionnements dans des conditions de court-circuit ou de circuit ouvert. L'étude théorique souligne la prise en compte de l'ensemble des phénomènes de recombinaison. L'obtention d'une bonne précision des mesures nécessite, avec une expérimentation rigoureuse, une connaissance précise des paramètres de structure de la photopile étudié. Pour la mesure de la durée de vie des porteurs, la plus grande sensibilité de la méthode en régime transitoire de court-circuit, comparée au régime de circuit ouvert, impose des mesures sous faible

  13. Luminescent Copper(I) Halide Butterfly Dimers Coordinated to [Au(CH3imCH2py)2]BF4 and [Au(CH3imCH2quin)2]BF4

    SciTech Connect

    Catalano, V.; Moore, A; Shearer, J; Kim, J

    2009-01-01

    The coordination chemistry of copper(I) halides to the homoleptic, N-heterocyclic carbene Au(I) complexes [Au(CH{sub 3}imCH{sub 2}quin){sub 2}]BF{sub 4} and [Au(CH{sub 3}imCH{sub 2}py){sub 2}]BF{sub 4} was explored. The reaction of CuX (X = Cl, Br, I) with either [Au(CH{sub 3}imCH{sub 2}quin){sub 2}]BF{sub 4} or [Au(CH{sub 3}imCH{sub 2}py){sub 2}]BF{sub 4} produces trimetallic complexes containing Cu{sub 2}X{sub 2}-butterfly copper clusters coordinated to the two imine moieties. The triangular arrangement of the metals places the gold(I) center in close proximity ({approx}2.5-2.6 {angstrom}) to the centroid of the Cu-Cu vector. The Cu-Cu separations vary as a function of bridging halide with the shortest Cu-Cu separations of {approx}2.5 {angstrom} found in the iodo-complexes and the longest separations of 2.9 {angstrom} found in the bridging chloride complexes. In all six complexes the Au-Cu separations range from {approx}2.8 to 3.0 {angstrom}. In the absence of halides, the dimetallic complex [AuCu(CH{sub 3}imCH{sub 2}py){sub 2}(NCCH{sub 3}){sub 2}](BF{sub 4}){sub 2}, containing a long Au-Cu distance of {approx}4.72 {angstrom} is formed. Additionally, as the byproduct of the reaction of CuBr with [Au(CH{sub 3}imCH{sub 2}quin){sub 2}]BF{sub 4} the deep-red, dimetallic compound, AuCuBr{sub 2}(CH{sub 3}imCH{sub 2}quin){sub 2}, was isolated in very low yield. All of these complexes were studied by NMR spectroscopy, mass spectrometry, and the copper containing species were additionally characterized by X-ray crystallography. In solution the copper centers dissociate from the gold complexes, but as shown by XANES and EXAFS spectroscopy, at low temperature the Cu-Cu linkage is broken, and the individual copper(I) halides reposition themselves to opposite sides of the gold complex while remaining coordinated to one imine moiety. In the solid state all of the complexes are photoluminescent, though the nature of the excited state was not determined.

  14. Luminescent copper(I) halide butterfly dimers coordinated to [Au(CH3imCH2py)2]BF4 and [Au(CH3imCH2quin)2]BF4.

    PubMed

    Catalano, Vincent J; Moore, Adam L; Shearer, Jason; Kim, Jineun

    2009-12-01

    The coordination chemistry of copper(I) halides to the homoleptic, N-heterocyclic carbene Au(I) complexes [Au(CH(3)imCH(2)quin)(2)]BF(4) and Au(CH(3)imCH(2)py)(2)]BF(4) was explored. The reaction of CuX (X = Cl, Br, I) with either [Au(CH(3)imCH(2)quin)(2)]BF(4) or [Au(CH(3)imCH(2)py)(2)]BF(4) produces trimetallic complexes containing Cu(2)X(2)-butterfly copper clusters coordinated to the two imine moieties. The triangular arrangement of the metals places the gold(I) center in close proximity (approximately 2.5-2.6 A) to the centroid of the Cu-Cu vector. The Cu-Cu separations vary as a function of bridging halide with the shortest Cu-Cu separations of approximately 2.5 A found in the iodo-complexes and the longest separations of 2.9 A found in the bridging chloride complexes. In all six complexes the Au-Cu separations range from approximately 2.8 to 3.0 A. In the absence of halides, the dimetallic complex [AuCu(CH(3)imCH(2)py)(2)(NCCH(3))(2)](BF(4))(2), containing a long Au-Cu distance of approximately 4.72 A is formed. Additionally, as the byproduct of the reaction of CuBr with [Au(CH(3)imCH(2)quin)(2)]BF(4) the deep-red, dimetallic compound, AuCuBr(2)(CH(3)imCH(2)quin)(2), was isolated in very low yield. All of these complexes were studied by NMR spectroscopy, mass spectrometry, and the copper containing species were additionally characterized by X-ray crystallography. In solution the copper centers dissociate from the gold complexes, but as shown by XANES and EXAFS spectroscopy, at low temperature the Cu-Cu linkage is broken, and the individual copper(I) halides reposition themselves to opposite sides of the gold complex while remaining coordinated to one imine moiety. In the solid state all of the complexes are photoluminescent, though the nature of the excited state was not determined. PMID:19899779

  15. Des-γ-Carboxyprothrombin (DCP) and NX-DCP Expressions and Their Relationship with Clinicopathological Features in Hepatocellular Carcinoma

    PubMed Central

    Sumi, Akiko; Akiba, Jun; Ogasawara, Sachiko; Nakayama, Masamichi; Nomura, Yoriko; Yasumoto, Makiko; Sanada, Sakiko; Nakashima, Osamu; Abe, Toshi; Yano, Hirohisa

    2015-01-01

    Aim Des-γ-carboxyprothrombin (DCP) has been used as a tumor marker for hepatocellular carcinoma (HCC). Recently the DCP/NX-DCP ratio, calculated by dividing DCP by NX-DCP, has been reported useful in detecting HCC. The purpose of this study is to clarify the significance of DCP and NX-DCP expression in HCC tissues. Methods HCC and non-HCC tissue samples were obtained from 157 patients and were immunohistochemically examined for DCP and NX-DCP expression using anti-DCP antibody and anti-NX-DCP antibody. DCP and NX-DCP expression scores were calculated by multiplying staining intensity grade by percentage of stained area. Serum DCP and NX-DCP levels were determined in 89 patients. We evaluated the relationship between tumor expression, serum level, and pathomorphological findings. Results Intrahepatic metastasis (im) was significantly more frequent in cases with high DCP expression than in cases with low DCP expression. High NX-DCP expression was associated with significantly lower histological grade, and less frequent im or portal vein invasion (vp) than low NX-DCP expression. Serum DCP was correlated with DCP expression, but serum NX-DCP was not correlated with NX-DCP expression. DCP-positive (≥40 mAU/L), NX-DCP-positive (≥90 mAU/L), and DCP/NX-DCP ratio-positive (≥1.5) cases were associated with significantly larger tumor size and more frequent vp than negative cases. DCP was rarely expressed, but NX-DCP was frequently expressed in non-cancerous liver tissues. Patients with NX-DCP expression-negative tumors showed a lower survival rate than those with NX-DCP expression-positive tumors (p = 0.04), whereas the survival in serum NX-DCP-positive cases was lower than that of serum negative cases (p = 0.02). Conclusions DCP and NX-DCP were produced in HCC tissues, but differed in expression level and biological properties. DCP expression, serum DCP or NX-DCP level, and DCP/NX-DCP ratio were closely related to malignant properties of HCC. PMID:25739032

  16. Simulations of the OzDES AGN reverberation mapping project

    NASA Astrophysics Data System (ADS)

    King, Anthea L.; Martini, Paul; Davis, Tamara M.; Denney, K. D.; Kochanek, C. S.; Peterson, Bradley M.; Skielboe, Andreas; Vestergaard, Marianne; Huff, Eric; Watson, Darach; Banerji, Manda; McMahon, Richard; Sharp, Rob; Lidman, C.

    2015-10-01

    As part of the Australian spectroscopic dark energy survey (OzDES) we are carrying out a large-scale reverberation mapping study of ≥500 quasars over five years in the 30 deg2 area of the Dark Energy Survey (DES) supernova fields. These quasars have redshifts ranging up to 4 and have apparent AB magnitudes between 16.8 mag < r < 22.5 mag. The aim of the survey is to measure time lags between fluctuations in the quasar continuum and broad emission-line fluxes of individual objects in order to measure black hole masses for a broad range of active galactic nuclei (AGN) and constrain the radius-luminosity (R-L) relationship. Here we investigate the expected efficiency of the OzDES reverberation mapping campaign and its possible extensions. We expect to recover lags for ˜35-45 per cent of the quasars. AGN with shorter lags and greater variability are more likely to yield a lag measurement, and objects with lags ≲6 months or ˜1 yr are expected to be recovered the most accurately. The baseline OzDES reverberation mapping campaign is predicted to produce an unbiased measurement of the R-L relationship parameters for H β, Mg II λ2798, and C IV λ1549. Extending the baseline survey by either increasing the spectroscopic cadence, extending the survey season, or improving the emission-line flux measurement accuracy will significantly improve the R-L parameter constraints for all broad emission lines.

  17. The Des Moines Plan: A Plan for Student Success.

    ERIC Educational Resources Information Center

    Castelda, Sharon; Wagner, Mary

    The Des Moines Plan (DMP) is described, which is a comprehensive kindergarten through grade 12 program designed to improve and strengthen students' reading, writing, and mathematics skills. The program was implemented during the fall semester of the 1986-87 school year. The DMP adopted the instructional model implemented by the Chapter 1 program…

  18. Recognition of Langue des Signes Quebecoise in Eastern Canada

    ERIC Educational Resources Information Center

    Parisot, Anne-Marie; Rinfret, Julie

    2012-01-01

    This article presents a portrait of two community-level and legal efforts in Canada to obtain official recognition of ASL and LSQ (Langue des signes quebecoise), both of which are recognized as official languages by the Canadian Association of the Deaf (CAD). In order to situate this issue in the Canadian linguistic context, the authors first…

  19. Mechanistic Enzymology of the Radical SAM Enzyme DesII

    PubMed Central

    2016-01-01

    DesII is a member of the radical SAM family of enzymes that catalyzes radical-mediated transformations of TDP-4-amino-4,6-didexoy-D-glucose as well as other sugar nucleotide diphosphates. Like nearly all radical SAM enzymes, the reactions begin with the reductive homolysis of SAM to produce a 5′-deoxyadenosyl radical which is followed by regiospecific hydrogen atom abstraction from the substrate. What happens next, however, depends on the nature of the substrate radical so produced. In the case of the biosynthetically relevant substrate, a radical-mediated deamination ensues; however, when this amino group is replaced with a hydroxyl, one instead observes dehydrogenation. The factors that govern the fate of the initially generated substrate radical as well as the mechanistic details underlying these transformations have been a key focus of research into the chemistry of DesII. This review will discuss recent discoveries pertaining to the enzymology of DesII, how it may relate to understanding other radical-mediated lyases and dehydrogenases and the working hypotheses currently being investigated regarding the mechanism of DesII catalysis.

  20. Simulations of the OzDES AGN reverberation mapping project

    SciTech Connect

    King, Anthea L.; Martini, Paul; Davis, Tamara M.; Denney, K. D.; Kochanek, C. S.; Peterson, Bradley M.; Skielboe, Andreas; Vestergaard, Marianne; Huff, Eric; Watson, Darach; Banerji, Manda; McMahon, Richard; Sharp, Rob; Lidman, C.

    2015-08-26

    As part of the Australian spectroscopic dark energy survey (OzDES) we are carrying out a large-scale reverberation mapping study of ~500 quasars over five years in the 30 deg2 area of the Dark Energy Survey (DES) supernova fields. These quasars have redshifts ranging up to 4 and have apparent AB magnitudes between 16.8 mag < r < 22.5 mag. The aim of the survey is to measure time lags between fluctuations in the quasar continuum and broad emission-line fluxes of individual objects in order to measure black hole masses for a broad range of active galactic nuclei (AGN) and constrain the radius–luminosity (R–L) relationship. Here we investigate the expected efficiency of the OzDES reverberation mapping campaign and its possible extensions. We expect to recover lags for ~35–45 % of the quasars. AGN with shorter lags and greater variability are more likely to yield a lag measurement, and objects with lags ≲6 months or ~1 yr are expected to be recovered the most accurately. The baseline OzDES reverberation mapping campaign is predicted to produce an unbiased measurement of the R–L relationship parameters for Hβ, MgIIλ2798, and C IVλ1549. As a result, extending the baseline survey by either increasing the spectroscopic cadence, extending the survey season, or improving the emission-line flux measurement accuracy will significantly improve the R–L parameter constraints for all broad emission lines.

  1. 75 FR 63714 - Drawbridge Operation Regulation; Des Allemands Bayou, LA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... Burlington Northern Santa Fe Railway swing bridge across Des Allemands Bayou, mile 14.0, in St. Charles and Lafourche Parishes, Louisiana. The deviation is necessary to perform extensive rehabilitation to the bridge. This deviation allows the bridge to remain closed to navigation completely from January 18,...

  2. 75 FR 35088 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--IMS Global Learning Consortium, Inc. Correction The document appearing on June 4, 2010, 75 FR 31816,...

  3. 77 FR 54611 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--IMS Global Learning Consortium, Inc. Notice is hereby given that, on July 16, 2012, pursuant to Section 6(a) of the National Cooperative Research...

  4. 78 FR 37571 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--IMS Global Learning Consortium, Inc. Notice is hereby given that, on May 30, 2013, pursuant to Section 6(a) of the National Cooperative Research...

  5. 76 FR 65536 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; IMS Global...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993; IMS Global Learning Consortium, Inc. Correction In notice document 2011-26426 appearing on page 63659 in...

  6. 75 FR 51114 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--IMS Global Learning Consortium, Inc. Notice is hereby given that, on July 13, 2010, pursuant to Section 6(a) of the National Cooperative Research...

  7. 76 FR 4723 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--IMS Global Learning Consortium, Inc. Correction In notice document 2011-78 appearing on page 1460 the issue of Monday, January 10, 2011 make the...

  8. 75 FR 64694 - Approval for Expanded Manufacturing Authority; Foreign-Trade Subzone 33E; DNP IMS America...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ... comment has been given in the Federal Register (75 FR 6635-6636, 2/10/2010) and the application has been... Foreign-Trade Zones Board Approval for Expanded Manufacturing Authority; Foreign-Trade Subzone 33E; DNP IMS America Corporation (Thermal Transfer Ribbon Printer Roll Manufacturing); Mount Pleasant,...

  9. 40 CFR 52.2348 - National Highway Systems Designation Act Motor Vehicle Inspection and Maintenance (I/M) Programs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 5 2014-07-01 2014-07-01 false National Highway Systems Designation... IMPLEMENTATION PLANS (CONTINUED) Utah § 52.2348 National Highway Systems Designation Act Motor Vehicle Inspection and Maintenance (I/M) Programs. (a) On March 15, 1996 the Governor of Utah submitted a revised...

  10. 40 CFR 52.2348 - National Highway Systems Designation Act Motor Vehicle Inspection and Maintenance (I/M) Programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 5 2013-07-01 2013-07-01 false National Highway Systems Designation... IMPLEMENTATION PLANS (CONTINUED) Utah § 52.2348 National Highway Systems Designation Act Motor Vehicle Inspection and Maintenance (I/M) Programs. (a) On March 15, 1996 the Governor of Utah submitted a revised...

  11. 40 CFR 52.2348 - National Highway Systems Designation Act Motor Vehicle Inspection and Maintenance (I/M) Programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 5 2012-07-01 2012-07-01 false National Highway Systems Designation... IMPLEMENTATION PLANS (CONTINUED) Utah § 52.2348 National Highway Systems Designation Act Motor Vehicle Inspection and Maintenance (I/M) Programs. (a) On March 15, 1996 the Governor of Utah submitted a revised...

  12. 5 CFR 894.304 - Am I eligible to enroll if I'm retired or receiving workers' compensation?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Am I eligible to enroll if I'm retired or receiving workers' compensation? 894.304 Section 894.304 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES DENTAL AND VISION...

  13. 5 CFR 894.304 - Am I eligible to enroll if I'm retired or receiving workers' compensation?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Am I eligible to enroll if I'm retired or receiving workers' compensation? 894.304 Section 894.304 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES DENTAL AND VISION...

  14. 5 CFR 894.304 - Am I eligible to enroll if I'm retired or receiving workers' compensation?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false Am I eligible to enroll if I'm retired or receiving workers' compensation? 894.304 Section 894.304 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES DENTAL AND VISION...

  15. 5 CFR 894.304 - Am I eligible to enroll if I'm retired or receiving workers' compensation?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Am I eligible to enroll if I'm retired or receiving workers' compensation? 894.304 Section 894.304 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES DENTAL AND VISION...

  16. Investigations in the solar wind and near the magnetopause during the IMS from the Prognoz 4, 5, and 6 satellites

    NASA Astrophysics Data System (ADS)

    Gringauz, K. I.; Bezrukikh, V. V.; Verigin, M. I.; Kotova, G. A.; Remizov, A. P.

    Prognoz 4-6 measurements of plasma, magnetic field, and energetic particles in the solar wind and near the magnetopause were carried out during the IMS (International Magnetospheric Studies). It is found that the outer radiation belt is a source of energetic (1 MeV) electrons in the magnetosheath near the magnetopause.

  17. EVALUATION OF CRYPTOSPORIDIUM OOCYST RECOVERY IN WATER BY EPA METHOD 1623 WITH A MODIFIED IMS DISSOCIATION PROCEDURE

    EPA Science Inventory

    U.S.EPA Methods 1622 and 1623 are used for the detection of waterborne Cryptosporium. These methods consist of filtration, elution, purificaiton by immunomagnetic separation (IMS), and microscopic analysis for oocysts stained by a fluorescent monoclonal antibody and counter stai...

  18. 5 CFR 894.304 - Am I eligible to enroll if I'm retired or receiving workers' compensation?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Am I eligible to enroll if I'm retired or receiving workers' compensation? 894.304 Section 894.304 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES DENTAL AND VISION...

  19. Hetgs Spectroscopy of the Long-Period Active Binary, im Pegasi.

    NASA Astrophysics Data System (ADS)

    Huenemoerder, David

    2001-09-01

    RS CVn binary systems are well known for their activity, interpreted as large-scale versions of Solar phenomena: spots, prominences, coronae, all with dynamic behavior. Stellar X-ray luminosity is well known to correlate with rotation and RS CVn stars are among the most luminous of late-type sources; they are prime candidates for X-ray spectroscopy. IM Peg is a long-period system (25d), and relatively X-ray luminous. We propose to obtain 8 HETGS spectra sampled several times during 2-3 rotations. Each exposure will well expose strong lines and also provide an integrated flux. Summed spectra will be used for deriviation of emission measure and abundances. Both long and short-term variability will be examined and correlated with activity diagnostics.

  20. Cure effects on microcracking in IM7 fiber/Matrimid 5292{reg_sign} BMI composites

    SciTech Connect

    Wilenski, M.S.; Shin, E.; Morgan, R.J.; Drzal, L.T.

    1995-12-31

    Initial results from a study of the microcracking behavior of the Matrimid 5292{reg_sign} BMI/IM7 carbon fiber system are presented. Studies were performed to determine the composite`s Stress Free Temperature (SFT) which is seen to control the presence and extent of microcracking. The SFT was determined using asymmetric laminates [0{sub 2}/90{sub 2}]. Varied post-cure cycles were utilized and it was found that until complete cure is obtained, the SFT is a function of the highest temperature experienced by the laminate, with little effect of previous thermal history. The reactions necessary to fully cure this system are not active at temperatures below 250 C, ruling out the possibility of obtaining a fully cured composite with a low SFT through extended post-cures at lower temperatures.

  1. A flare event of the long-period RS Canum Venaticorum system IM Pegasi

    NASA Technical Reports Server (NTRS)

    Buzasi, Derek L.; Ramsey, Lawrence W.; Huenemoerder, David P.

    1987-01-01

    The characteristics of a flare event detected on the long-period RS CVn system IM Pegasi are reported. The low-resolution spectrum show enhancements of up to a factor of five in some emission lines. All of the ultraviolet emission lines normally visible are enhanced significantly more than the normal 30 rotational modulation. Emission fluxes of both the quiescent and flare event are used to construct models of the density and temperature variation with height. These models reveal a downward shift of the transition region during the flare. Scaled models of the quiet and flaring solar outer atmosphere are used to estimate the filling factor of the flare event at about 30 percent of the stellar surface. The pattern of line enhancements in the flare is the same as a previous event in Lambda Andromeda observed previously.

  2. PAPR reduction based on chaos combined with SLM technique in optical OFDM IM/DD system

    NASA Astrophysics Data System (ADS)

    Xiao, Yaoqiang; Chen, Ming; Li, Fan; Tang, Jin; Liu, Yi; Chen, Lin

    2015-01-01

    This paper proposes a method to decrease the PAPR of 16-quadrature-amplitude-modulation (16QAM) orthogonal-frequency-division-multiplexing (OFDM) signal. The method is to combine chaos with selected mapping (CSLM) technique so that the chaotic sequences are able to control generation of phase rotation factors. The research has utilized this method to transmit OFDM signal along 100 km long single-mode fiber in an IM/DD system to test OFDM signal performance. Our experimental results show that the receiver sensitivity is improved by about 1.4 dB when a 3.28 GB/s OFDM signal at a bit error rate of 1 × 10-3 is launched by transmission power at 2, 6, 8 and 10 dBm, respectively. Moreover, comparison with traditional SLM technique, the CSLM technique can improve the BER of the system.

  3. Cometary ion flow variations at Comet P/Halley as observed by the Giotto IMS experiment

    NASA Technical Reports Server (NTRS)

    Kettmann, G.; Ip, W.-H.; Balsiger, H.; Meier, A.; Goldstein, B. E.

    1990-01-01

    The moments of the cometary-ion distributions are determined through a three-dimensional analysis of the Giotto IMS high-intensity spectrometer (HIS) data. The spectrometer is described, with emphasis on its angle analyzer and mass analyzer. The method of data analysis is outlined, with ion-flow vectors and temperatures being addressed. The results of the water group ion-flow profile are presented, and it is noted that, after crossing the cometopause region, the ions become gradually colder. At cometocentric distances larger than 130,000 km, the cometary-ion temperature is found to be in the area of 100 eV or higher, and derivations of the flow parameters are uncertain. The ion temperature and the flow speed become lower by about 50 eV after crossing the magnetic pile-up boundary. It is concluded that the observed velocity and temperature profiles can be explained on the basis of charge exchange processes.

  4. Hypervelocity Impact Testing of IM7/977-3 with Micro-Sized Particles

    NASA Technical Reports Server (NTRS)

    Smith, J. G.; Jegley, D. C.; Siochi, E. J.; Wells, B. K.

    2010-01-01

    Ground-based hypervelocity imapct testing was conducted on IM7/977-3 quasi-isotropic flat panels at normal incidence using micron-sized particles (i.e. less than or equal to 100 microns) of soda lime glass and olivine. Testing was performed at room temperature (RT) and 175 C with results from the 175 C test compared to those obtained at RT. Between 10 and 30 particles with velocities ranging from 5 to 13 km/s impacted each panel surface for each test temperature. Panels were ultrasonically scanned prior to and after impact testing to assess internal damage. Post-impact analysis included microscopic examination of the surface, determination of particle speed and location, and photomicroscopy for microcrack assessment. Internal damage was observed by ultrasonic inspection on panels impacted at 175 C, whereas damage for the RT impacted panels was confined to surface divets/craters as determined by microscopic analysis.

  5. Miniature GC: Minicell ion mobility spectrometer (IMS) for astrobiology planetary missions

    NASA Technical Reports Server (NTRS)

    Kojiro, Daniel R.; Holland, Paul M.; Stimac, Robert M.; Kaye, William J.; Takeuchi, Norishige

    2006-01-01

    Astrobiology flight experiments require highly sensitive instrumentation for in situ analysis of volatile chemical species and minerals present in the atmospheres and surfaces of planets, moons, and asteroids. The complex mixtures encountered place a heavy burden on the analytical instrumentation to detect and identify all species present. The use of land rovers and balloon aero-rovers place additional emphasis on miniaturization of the analytical instrumentation. In addition, smaller instruments, using tiny amounts of consumables, allow the use of more instrumentation and/or longer mission life for stationary landers/laboratories. We describe here the development of a miniature GC - Minicell Ion Mobility Spectrometer (IMS) under development through NASA's Astrobiology Science and Technology Instrument Development (ASTID) Program and NASA's Small Business Innovative Research (SBIR) Program.

  6. Regional and Global Atmospheric CO2 Measurements Using 1.57 Micron IM-CW Lidar

    NASA Technical Reports Server (NTRS)

    Lin, Bing; Obland, Michael; Nehrir, Amin; Browell, Edward; Harrison, F. Wallace; Dobler, Jeremy; Campbell, Joel; Kooi, Susan; Meadows, Byron; Fan, Tai-Fang; Liu, Zhaoyan

    2015-01-01

    Atmospheric CO2 is a critical forcing for the Earth's climate, and knowledge of its distribution and variations influences predictions of the Earth's future climate. Accurate observations of atmospheric CO2 are also crucial to improving our understanding of CO2 sources, sinks and transports. To meet these science needs, NASA is developing technologies for the Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) space mission, which is aimed at global CO2 observations. Meanwhile an airborne investigation of atmospheric CO2 distributions as part of the NASA Suborbital Atmospheric Carbon and Transport â€" America (ACT-America) mission will be conducted with lidar and in situ instrumentation over the central and eastern United States during all four seasons and under a wide range of meteorological conditions. In preparing for the ASCENDS mission, NASA Langley Research Center and Exelis Inc./Harris Corp. have jointly developed and demonstrated the capability of atmospheric CO2 column measurements with an intensity-modulated continuous-wave (IM-CW) lidar. Since 2005, a total of 14 flight campaigns have been conducted. A measurement precision of approx.0.3 ppmv for a 10-s average over desert and vegetated surfaces has been achieved, and the lidar CO2 measurements also agree well with in-situ observations. Significant atmospheric CO2 variations on various spatiotemporal scales have been observed during these campaigns. For example, around 10-ppm CO2 changes were found within free troposphere in a region of about 200A-300 sq km over Iowa during a summer 2014 flight. Results from recent flight campaigns are presented in this paper. The ability to achieve the science objectives of the ASCENDS mission with an IM-CW lidar is also discussed in this paper, along with the plans for the ACT-America aircraft investigation that begins in the winter of 2016.

  7. P2IMS depth profile analysis of high temperature boron oxynitride dielectric films

    NASA Astrophysics Data System (ADS)

    Badi, N.; Vijayaraghavan, S.; Benqaoula, A.; Tempez, A.; Tauziède, C.; Chapon, P.

    2014-02-01

    Existing silicon oxynitride (SiON) dielectric can only provide a very near term solution for the metal oxide semiconductor technology. The emerging high-k dielectric materials have a limited thermal stability and are prone to electrical behavior degradation which is associated with unwanted chemical reactions with silicon (Si). We investigated here applicability of amorphous boron oxynitride (BON) thin films as an emerging dielectric for high temperature capacitors. BON samples of thickness varying from 200 nm down to 10 nm were deposited in a high vacuum reactor using ion source assisted physical vapor deposition (PVD) technique. Plasma profiling ion mass spectrometry (P2IMS) was utilized to specifically determine the interface quality and best capacitor performance as a function of growth temperatures of a graded sample with alternate layers of deposited titanium (Ti) and BON layers on Si. P2IMS depth profiling of these layers were also performed to evaluate the stability of the dielectric layers and their efficacy against B dopant diffusion simulating processes occurring in activated polySi-based devices. For this purpose, BON layers were deposited on boron-isotope 10 (B10) implanted Si substrates and subsequently annealed at high temperatures up to 1050 °C for about 10 s. Results comparing inter-diffusion of B10 intensities at the interfaces of BON-Si and SiON-Si samples suggest suitability of BON as barrier layers against boron diffusion at high temperature. Stable Ti/BON/Ti capacitor behavior was achieved at optimum growth temperature of 600 °C of the BON dielectric layer. Capacitance change with frequency (10 kHz to 2 MHz) and temperature up to 400 °C is about 1% and 10%, respectively.

  8. Solubility of alkali metal halides in the ionic liquid [C4C1im][OTf].

    PubMed

    Kuzmina, O; Bordes, E; Schmauck, J; Hunt, P A; Hallett, J P; Welton, T

    2016-06-28

    The solubilities of the metal halides LiF, LiCl, LiBr, LiI, NaF, NaCl, NaBr, NaI, KF, KCl, KBr, KI, RbCl, CsCl, CsI, were measured at temperatures ranging from 298.15 to 378.15 K in the ionic liquid 1-butyl-3-methylimidazolium trifluoromethanesulfonate ([C4C1im][OTf]). Li(+), Na(+) and K(+) salts with anions matching the ionic liquid have also been investigated to determine how well these cations dissolve in [C4C1im][OTf]. This study compares the influence of metal cation and halide anion on the solubility of salts within this ionic liquid. The highest solubility found was for iodide salts, and the lowest solubility for the three fluoride salts. There is no outstanding difference in the solubility of salts with matching anions in comparison to halide salts. The experimental data were correlated employing several phase equilibria models, including ideal mixtures, van't Hoff, the λh (Buchowski) equation, the modified Apelblat equation, and the non-random two-liquid model (NRTL). It was found that the van't Hoff model gave the best correlation results. On the basis of the experimental data the thermodynamic dissolution parameters (ΔH, ΔS, and ΔG) were determined for the studied systems together with computed gas phase metathesis parameters. Dissolution depends on the energy difference between enthalpies of fusion and dissolution of the solute salt. This demonstrates that overcoming the lattice energy of the solid matrix is the key to the solubility of inorganic salts in ionic liquids. PMID:27264676

  9. L'Infection Nosocomiale en Reanimation des Brules

    PubMed Central

    Siah, S.; Belefqih, R.; Elouennass, M.; Fouadi, F.E.; Ihrai, I.

    2009-01-01

    Summary L'infection nosocomiale bactérienne étant l'une des principales causes de morbidité et de mortalité chez le brûlé, nous avons réalisé une étude rétrospective portant sur 84 patients hospitalisés au sein du service de réanimation des brûlés de l'Hôpital Militaire d'Instruction Mohammed V de Rabat, sur une période de 3 ans, du premier janvier 2001 au 31 décembre 2003. Les critères d'infection nosocomiale étaient ceux du Center for Disease Control d'Atlanta de 1988. Les taux d'incidence ont été calculés. La population infectée a été comparée à celle non infectée. L'écologie bactérienne du service a été décrite comme aussi l'antibiotype. Il ressort de cette étude la survenue de 87 infections nosocomiales chez 27 patients. L'incidence cumulative était de 103 infections pour 1000 jours de traitement. Pour ce qui est des caractéristiques des infections bactériennes, les sites infectés étaient la peau (77%), le sang (13,8%), les voies urinaires (8%) et les poumons (1,1%). Les principaux germes étaient: Staphylococcus sp. (33,3%), Pseudomonas aeruginosa (23%), Enterococcus faecalis et Acinetobacter (8%). Les staphylocoques étaient méticillo-résistants dans 22,2% des cas. Le Pseudomonas et l'Acinetobacter étaient multirésistants (60%). Dans notre étude les facteurs prédictifs de survenue des infections nosocomiales que nous avons retenus après l'étude comparative des populations infectées et non infectées ont été l'âge, le body mass index, l'abbreviated burn severity index et le remplissage initial. En isolant ces paramètres, nous avons pu établir une équation à valeur prédictive de survenue d'infection nosocomiale chez le patient brûlé. PMID:21991158

  10. Lignes directrices canadiennes sur l’utilisation sécuritaire et efficace des opioïdes pour la douleur chronique non cancéreuse

    PubMed Central

    Kahan, Meldon; Wilson, Lynn; Mailis-Gagnon, Angela; Srivastava, Anita

    2011-01-01

    Résumé Objectif Présenter aux médecins de famille un résumé clinique pratique sur la prescription d’opioïdes à des populations particulières en se fondant sur les recommandations faites dans les lignes directrices canadiennes sur l’utilisation sécuritaire et efficace des opioïdes pour la douleur chronique non cancéreuse. Qualité des données Pour produire les lignes directrices, les chercheurs ont effectué une synthèse critique de la littérature médicale en insistant plus précisément sur les études de l’efficacité et de la sécurité des opioïdes dans des populations particulières. Message principal Les médecins de famille peuvent atténuer les risques de surdose, de sédation, d’usage abusif et de dépendance grâce à des stratégies adaptées à l’âge et à l’état de santé des patients. Dans le cas de patients à risque de dépendance, on devrait réserver les opioïdes aux douleurs nociceptives ou neuropathiques bien définies qui n’ont pas répondu aux traitements de première intention. Il faut procéder lentement au titrage des opioïdes, avec des dispensations fréquentes et une étroite surveillance pour dépister tout signe d’usage abusif. Une dépendance aux opioïdes suspectée est prise en charge au moyen d’une thérapie structurée aux opioïdes, d’un traitement à la méthadone ou à la buprénorphine ou encore d’un traitement fondé sur l’abstinence. Les patients souffrant de troubles de l’humeur ou d’anxiété ont tendance à avoir une réponse analgésique atténuée aux opioïdes, sont à risque plus élevé d’usage abusif et prennent souvent des sédatifs qui interagissent défavorablement avec les opioïdes. Il faut prendre des précautions semblables à celles utilisées avec d’autres patients à risque élevé. Il faut faire un sevrage progressif si la douleur du patient demeure sévère même avec un essai adéquat de thérapie aux opioïdes. Chez les personnes âgées, la s

  11. Les reseaux de politique publique comme facteur d'influence du choix des instruments de politique energetique canadienne a des fins environnementales de 1993 a nos jours

    NASA Astrophysics Data System (ADS)

    Fathy El Dessouky, Naglaa

    Au cours de la derniere decennie, les modes de la gouvernance ont pris place dans un contexte totalement different de celui qu'ils avaient auparavant. Les gouvernements modernes se rendent compte qu'ils perdent de plus en plus leur capacite a elaborer et a gerer les changements d'une maniere autonome. Ainsi, les fonctions et les activites traditionnellement accomplies exclusivement par le gouvernement engagent de nos jours une gamme d'acteurs etatiques et non etatiques. A l'encontre du concept traditionnel de l'Etat controleur, la gouvernance contemporaine est ainsi devenue moins une question d'offre de service et davantage une gestion indirecte des reseaux de politique publique. Dans cette entreprise, les gouvernements contemporains, cherchant plus d'information, de soutien et de legitimite en matiere de formulation des decisions, ont besoin d'etablir des relations avec les divers groupes d'interet qui, a leur tour, voulaient plus de promotion et de protection en faveur de leurs interets a travers leur implication au processus de l'elaboration et de la mise en oeuvre des politiques publiques. Ainsi, l'approche des reseaux de politique publique represente aujourd'hui un courant considerable au sein du champ d'analyse des politiques publiques. Toutefois, les preoccupations des chercheurs pour cette approche, dans le domaine des politiques energetiques a des fins environnementales, semblent recentes, et les etudes realisees sont encore trop peu nombreuses. Au Canada, au debut des annees 1990, le gouvernement ainsi que plusieurs groupes d'interets, des differents secteurs energetique, industriel et environnemental, ont commence a intensifier leurs efforts pour s'attaquer au probleme du changement climatique d'origine energetique, genere surtout par le secteur de l'industrie. Au cours de la derniere decennie, la question touchant plutot le sujet du developpement energetique durable represente le plus important domaine des politiques publiques ayant surgi recemment dans

  12. Relation entre les caractéristiques des table-bancs et les mesures anthropométriques des écoliers au Benin

    PubMed Central

    Falola, Stève Marjelin; Gouthon, Polycarpe; Falola, Jean-Marie; Fiogbe, Michel Armand; Nigan, Issiako Bio

    2014-01-01

    Introduction Le mobilier scolaire et la posture assise en classe sont souvent impliqués dans l'apparition des douleurs rachidiennes, influant de fait sur la qualité des tâches réalisées par les apprenants. Aucune étude n'a encore vérifié le degré d'adéquation entre les caractéristiques du mobilier et celles des écoliers au Bénin. L'objectif de cette étude transversale est donc de déterminer la relation entre les dimensions des table-bancs utilisées en classe et les mesures anthropométriques des écoliers au Bénin. Methods Elle a été réalisée avec un échantillon probabiliste de 678 écoliers, âgés de 4 à 17 ans. Les mesures anthropométriques des écoliers et les mensurations relatives aux longueurs, largeurs et hauteurs des table-bancs ont été mesurées, puis intégrées aux équations proposées dans la littérature. Les pourcentages des valeurs situées hors des limitesacceptables, dérivées de l'application des équations ont été calculés. Results La largeur et la hauteur des table-bancs utilisées par les écoliers étaient plus élevées (p < 0,05) que les valeurs de référence recommandées par les structures officielles de contrôle et de production des mobiliers scolaires au Bénin. Quel que soit le sexe, il y avait une inadéquation entre la largeur du banc et la longueur fesse-poplité, puis entre la hauteur de la table et la distance coude-bancdes écoliers. Conclusion Les résultats suggèrent de prendre en compte l’évolution des mesures anthropométriques des écoliers dans la confection des table-bancs, afin de promouvoir de bonnes postures assises en classe et de réduire le risque de troubles du rachis. PMID:25317232

  13. Optimisation des proprietes fonctionnelles des alliages a memoire de forme suite a l'application de traitements thermomecaniques

    NASA Astrophysics Data System (ADS)

    Demers, Vincent

    L'objectif de ce projet est de determiner les conditions de laminage et la temperature de traitement thermique maximisant les proprietes fonctionnelles de l'alliage a memoire de forme Ti-Ni. Les specimens sont caracterises par des mesures de calorimetrie, de microscopie optique, de gene ration de contrainte, de deformation recuperable et des essais mecaniques. Pour un cycle unique, l'utilisation d'un taux d'ecrouissage e=1.5 obtenu avec l'application d'une force de tension FT = 0.1sigma y et d'une huile minerale resulte en un echantillon droit, sans microfissure et qui apres un recuit a 400°C, produit un materiau nanostructure manifestant des proprietes fonctionnelles deux fois plus grandes que le meme materiau ayant une structure polygonisee. Pour des cycles repetes, les memes conditions de laminage sont valables mais le niveau de deformation optimal est situe entre e=0.75-2, et depend particulierement du mode de sollicitation, du niveau de stabilisation et du nombre de cycles a la rupture requis par l'application.

  14. Dépistage des maladies cardiovasculaires chez des étudiants de l'Université de Douala et influence des activités physiques et sportives

    PubMed Central

    Ewane, Marielle Epacka; Mandengue, Samuel Honoré; Priso, Eugene Belle; Tamba, Stéphane Moumbe; Ahmadou; Fouda, André Bita

    2012-01-01

    Introduction Les maladies cardiovasculaires (MCV) constituent l'une des principales causes de mortalité dans les pays en développement. Le dépistage de ces dernières chez des jeunes est un défi dans la lutte contre leur expansion. Le but de cette étude était de dépister ces maladies au sein d'une population jeunes d’étudiants camerounais. Methodes Deux mille six cent cinquante-huit étudiants de l'Université de Douala (23,6 ± 2,9 ans, sex-ratio H/F = 0,9) ont en Avril - Mai 2011 participé à une campagne de dépistage gratuit du diabète, de l'hypertension artérielle (HTA) et de l'obésité. Ils ont également été soumis à une d'enquête évaluant leur niveau en activités physiques et sportives (APS). Resultats 12,7% des participants avaient une pression artérielle (PA) ≥ 140/90 mmHg, 3,6% étaient obèses et 0,9% avaient une glycémie ≥1,26 g/L. Des corrélations ont été trouvées entre certains facteurs de risque (diabète, hypertension et obésité) et le niveau académique d'une part (r =0,366; p < 0,0001) et le temps passé devant la télévision d'autres part (r = 0,411; p < 0,0001). L‘APS était inversement corrélée à l‘âge (r =-0,015; p < 0,0001) et au temps passé devant la télévision (r = -0,059; p = 0,002). Conclusion La présence des MCV et leurs facteurs de risque mis en évidence dans cette étude réalisée en milieu estudiantin camerounais interpelle à une prévention et une éducation dans la lutte contre ces dernières. PMID:22655111

  15. Measurement of exhaled volatile organic compounds from patients with chronic obstructive pulmonary disease (COPD) using closed gas loop GC-IMS and GC-APCI-MS.

    PubMed

    Allers, M; Langejuergen, J; Gaida, A; Holz, O; Schuchardt, S; Hohlfeld, J M; Zimmermann, S

    2016-06-01

    Due to its high sensitivity, compact size and low cost ion mobility spectrometry (IMS) has the potential to become a point-of-care breath analyzer. Therefore, we developed a prototype of a compact, closed gas loop IMS with gas chromatographic (GC) pre-separation and high resolving power of R  =  90. In this study, we evaluated the performance of this GC-IMS under clinical conditions in a COPD study to find correlations between VOCs (10 ppbv to 1 ppmv) and COPD. Furthermore, in order to investigate possible correlations between ultra-low concentrated breath VOCs (0.1 pptv to 1 ppbv) and COPD, a modified mass spectrometer (MS) with atmospheric pressure chemical ionization (APCI) and GC pre-separation (GC-APCI-MS) was used. The GC-IMS has been used in 58 subjects (21 smokers with moderate COPD, 12 ex-smokers with COPD, 16 healthy smokers and 9 non-smokers). GC-APCI-MS data were available for 94 subjects (21 smokers with moderate COPD, 25 ex-smokers with COPD, 25 healthy smokers and 23 non-smokers). For 44 subjects, a comparison between GC-IMS and GC-APCI-MS data could be performed. Due to service intervals, subject availability and corrupt data, patient numbers were different for GC-APCI-MS and GC-IMS measurements. Using GC-IMS, three VOCs have been found showing a significant difference between healthy controls and patients with COPD. In the GC-APCI-MS data, we only observed one distinctive VOC, which has been identified as 2-pentanone. This proof-of-principle study shows the potential of our high-resolution GC-IMS in the clinical environment. Due to different linear dynamic response ranges, the data of GC-IMS and GC-APCI-MS were only comparable to a limited extent. PMID:27058460

  16. Plasma IMS Composition Measurements for Europa and the Other Galilean Moons

    NASA Technical Reports Server (NTRS)

    Sittler, Edward; Cooper, John; Hartle, Richard; Lipatov, Alexander; Mahaffy, Paul; Paterson, William; Pachalidis, Nick; Coplan, Mike; Cassidy, Tim

    2010-01-01

    NASA and ESA are planning the joint Europa Jupiter System Mission (EJSM) to the Jupiter system with specific emphasis to Europa and Ganymede, respectively. The Japanese Space Agency is also planning an orbiter mission to explore Jupiter's magnetosphere and the Galilean satellites. For NASA's Jupiter Europa Orbiter (JEO) we are developing the 3D Ion Mass Spectrometer (IMS) with two main goals which can also be applied to the other Galilean moons, 1) measure the plasma interaction between Europa and Jupiter's magnetosphere and 2) infer the 4 pi surface composition to trace elemental and significant isotopic levels. The first goal supports the magnetometer (MAG) measurements, primarily directed at detection of Europa's sub-surface ocean, while the second gives information about transfer of material between the Galilean moons, and between the moon surfaces and subsurface layers putatively including oceans. The measurement of the interactions for all the Galilean moons can be used to trace the in situ ion measurements of pickup ions back to either Europa's or Ganymede's surface from the respectively orbiting spacecraft. The IMS instrument, being developed under NASA's Astrobiology Instrument Development Program, would maximally achieve plasma measurement requirements for JEO and EJSM while moving forward our knowledge of Jupiter system composition and source processes to far higher levels than previously envisaged. The composition of the global surfaces of Europa and Ganymede can be inferred from the measurement of ejected neutrals and pick-up ions using at minimum an in situ payload including MAG and IMS also fully capable of meeting Level 1 mission requirements for ocean detection and survey. Elemental and isotopic analysis of potentially extruded oceanic materials at the moon surfaces would further support the ocean objectives. These measurements should be made from a polar orbiting spacecraft about Europa or Ganymede at height 100 km. The ejecta produced by

  17. The importance of polarizability: comparison of models of carbon disulphide in the ionic liquids [C1C1im][NTf2] and [C4C1im][NTf2].

    PubMed

    Lynden-Bell, Ruth M; Quitevis, Edward L

    2016-06-28

    The local environment of CS2 and in solution in two ionic liquids ([C1C1im][NTf2] and [C4C1im][NTf2]) are investigated by atomistic simulation and compared with that in neat CS2. The intermolecular vibrational densities of states of CS2 are calculated and compared with experimental OHD-RIKES spectra. The fair agreement of the results from solutions but poor agreement of the results from neat CS2 suggest that while collective effects are unimportant in solutions, they have a major effect on the OHD-RIKES spectrum of neat CS2. Comparing polarizable and unpolarizable models for CS2 emphasizes the importance of polarizability in determining local structure. PMID:27273458

  18. Prise en charge des complications des fistules artério-veineuses pour hémodialyse chronique

    PubMed Central

    Jiber, Hamid; Zrihni, Youssef; Zaghloul, Rachid; Hajji, Rita; Zizi, Othman; Bouarhroum, Abdellatif

    2015-01-01

    La fistule artério-veineuse native est l'accès vasculaire de choix pour l'hémodialyse chronique en raison de sa longévité, son taux faible de complication et de mortalité par rapport aux pontages artério-veineux et aux cathéters. Cependant, il arrive assez souvent que l'on assiste à des complications qui sont dominées par la sténose et la thrombose. C'est une étude rétrospective des complications ayants survenues pour 31 fistules artério-veineuses pour hémodialyse chronique des 200 fistules réalisées chez 200 patients au sein du service de chirurgie vasculaire du CHU Hassan II de Fès sur une période de trois ans, étendue de Janvier 2007 à Décembre 2009. Ces complications ont été présentés par les thromboses dans 14 cas soit 45,15% de l'ensemble des complications, les sténoses dans 4 cas (12,90%,) les anévrismes dans 4 cas (12,90%), les complications ischémiques dans 3 cas (9,67%), l'infection dans 3 cas (9,67%), l'hémorragie dans 2 cas (6,45%) et l’ hyperdébit dans un seul cas soit 3,22%. On a pu conserver 22 fistules soit 70,96% par traitement chirurgical ou endovasculaire, on a confectionné une nouvelle fistule dans 8 cas soit 25,80%, et on a adressé une patiente (3,22%) pour pose d'un cathéter veineux tunnelisé permanent. Les complications des fistules artério-veineuses pour l'hémodialyse chronique sont la principale cause de morbidité chez les patients hémodialysés, il est donc important de s'impliquer lors de leur création, et de donner un maximum d'attention quand ils sont manipulés. Ceci suggère la mise en place d'un programme de surveillance de ces fistules en raison de l'impact des complications sur la morbi-mortalité du patient hémodialysé et sur le plan financier. PMID:26113933

  19. Acupuncture Au Laser He-Ne: Traitement Des Infections Rhinopharyngees

    NASA Astrophysics Data System (ADS)

    Dussert, Dr.

    1984-03-01

    Mesdames, Messieurs, y a 23 mois, je recevais l'urgence suivante dans mon cabinet medical : 1) Un homme de 53 ans, dyspneioue (cliniquement it etait en Bradypnee expiratoire). Il venait d'être hospitalise 1 mois et avait ete place sous cortisone. Je le fais assoir, et j'irradie avec un laser sur chacun des ganglions stellaires pendant 6 minutes je debloque ce malade qui se met e respirer normalement. 2) Quelques temps apres : C'est un enfant de 7 ans que je regois en crise d'asthme. J'irradie sur chacun des ganglions stellaires pendant 4 minutes une onde laser d'impulsion 6 et en basse freouence. L'enfant voit s'estomper la crise d'asthme. Devant ces deux cas, je decide d'organiser un travail de recherche.

  20. Des recommandations probantes pour surveiller l’innocuité des antipsychotiques de deuxième génération chez les enfants et les adolescents

    PubMed Central

    Pringsheim, Tamara; Panagiotopoulos, Constadina; Davidson, Jana; Ho, Josephine

    2012-01-01

    HISTORIQUE : Au Canada, l’utilisation d’antipsychotiques, notamment les antipsychotiques de deuxième génération (ADG), a augmenté de façon considérable depuis cinq ans chez les enfants ayant des troubles de santé mentale. Ces médicaments ont le potentiel de causer de graves complications métaboliques et neurologiques lorsqu’on les utilise de manière chronique. OBJECTIF : Synthétiser les données probantes relatives aux effets secondaires métaboliques et neurologiques précis associés à l’usage d’ADG chez les enfants et fournir des recommandations probantes sur la surveillance de ces effets secondaires. MÉTHODOLOGIE : Les auteurs ont procédé à une analyse systématique des essais cliniques contrôlés des ADG auprès d’enfants. Ils ont fait des recommandations à l’égard de la surveillance de l’innocuité des ADG d’après un modèle de classification fondé sur le système GRADE (système de notation de l’évaluation et de l’élaboration des recommandations). Lorsque les données probantes n’étaient pas suffisantes, ils fondaient leurs recommandations sur le consensus et l’avis d’experts. Un groupe consensuel multidisciplinaire a analysé toutes les données probantes pertinentes et est parvenu à un consensus à l’égard des recommandations. RÉSULTATS : Les recommandations probantes portant sur la surveillance de l’innocuité des ADG figurent dans les présentes lignes directrices. Les auteurs indiquent la qualité des recommandations relatives à des examens physiques et tests de laboratoire précis à l’égard de chaque ADG à des moments déterminés. CONCLUSION : De multiples essais aléatoires et contrôlés ont permis d’évaluer l’efficacité de bon nombre des ADG utilisés pour traiter les troubles de santé mentale en pédiatrie. Toutefois, leurs avantages ne sont pas sans risques : on observe à la fois des effets secondaires métaboliques et neurologiques chez les enfants traités au moyen d

  1. Modelisations des effets de surface sur les jets horizontaux subsoniques d'hydrogene et de methane

    NASA Astrophysics Data System (ADS)

    Gomez, Luis Fernando

    Le developpement des codes et de normes bases sur une methodologie scientifique requiert la capacite de predire l'etendue inflammable de deversements gazeux d'hydrogene sous differentes conditions. Des etudes anterieures ont deja etabli des modeles bases sur les lois de conservation de la mecanique des fluides basees sur des correlations experimentales qui permettent de predire la decroissance de la concentration et de la vitesse d'un gaz le long de l'axe d'un jet libre vertical. Cette etude s'interesse aux effets de proximite a une surface horizontale parallele sur un jet turbulent. Nous nous interessons a son impact sur l'etendue du champ de la concentration et sur l'enveloppe inflammable en particulier. Cette etude est comparative : l'hydrogene est compare au methane. Ceci permet de degager l'influence des effets de difference de la densite sur le comportement du jet, et de comparer le comportement de l'hydrogene aux correlations experimentales, qui ont ete essentiellement etablies pour le methane. Un modele decrivant l'evolution spatio-temporelle du champ de concentration du gaz dilue est propose, base sur la mecanique des fluides computationnelle. Cette approche permet de varier systematiquement les conditions aux frontieres (proximite du jet a la surface, par exemple) et de connaitre en detail les proprietes de l'ecoulement. Le modele est implemente dans le code de simulations par volumes finis de FLUENT. Les resultats des simulations sont compares avec les lois de similitudes decoulant de la theorie des jets d'ecoulements turbulents libres ainsi qu'avec les resultats experimentaux disponibles. L'effet de la difference des masses molaires des constituantes du jet et des constituantes du milieu de dispersion est egalement etudie dans le contexte du comportement d'echelle de la region developpee du jet.

  2. Partager : des technologies de pointe au service de la société

    ScienceCinema

    None

    2011-10-06

    Médecine, climatologie, métrologie et informatique, les techniques utilisées par le LHC trouvent déjà des répercussions dans d?autres domaines scientifiques. Utilisant des techniques inédites, la physique des particules en fait bénéficier la société toute entière.

  3. Landform Variability in the Chaine Des Puys Tracing Multiple Processes

    NASA Astrophysics Data System (ADS)

    van Wyk de Vries, B.; Grosse, P.

    2014-12-01

    The Chaîne des Puys is a highly varied, type monogenetic field, and was acknowledged by 38th WH UNESCO Committee to contain Outstanding Universal Value. The Chaîne des Puys - Limagne Fault should be presented in 2016 for World Heritage Status. The 30 km long Chaîne des Puys contains ranges from simple basaltic scoria cones to complex, multicrater cones, and small simple domes to complicated trachytic edifices. There is also a range of phreatomagmatic landforms from tuff rings to maars and vulcanian to sub plinian deposits. There is a wide range of pahoehoe and aa lava types, that have flowed over different topographies. Here we take morphometrical data to analyse the variability of the edifices using a 10 m regional topographic DTM. The volcanoes form a broad continuum of morphological features, and height/widths of domes and cones overlap. Some edifices, are smooth and elliptical, even though they have erupted complex lava sequences, while others complex shapes, but are related to simple lava flows. There seems to be no easy correlation between cone morphology and eruption histories derived from lava fields and distal tephras. In the few cones where the interior is visible, the shape of the cone is seen to vary with changing eruption events. The final shape is a combination of changing activity, with the last events having the strongest morphometic signature. The broad variations in edifice, lava field, and deposit morphology are described and quantified, however it becomes clear from the few individual eruptions already studied, that to fully appreciate the range of monogenetic eruption scenarios presented by the Chaîne des Puys, much more detailed work is required. This is being made possible by new acquisitions of LiDAR imagery, new geophysical work, and the combination of excellent preservation and extensive outcrop that is partly the result the original geology and long term responsible land management by the local populace, regional park and local

  4. Simulations of the OzDES AGN reverberation mapping project

    DOE PAGESBeta

    King, Anthea L.; Martini, Paul; Davis, Tamara M.; Denney, K. D.; Kochanek, C. S.; Peterson, Bradley M.; Skielboe, Andreas; Vestergaard, Marianne; Huff, Eric; Watson, Darach; et al

    2015-08-26

    As part of the Australian spectroscopic dark energy survey (OzDES) we are carrying out a large-scale reverberation mapping study of ~500 quasars over five years in the 30 deg2 area of the Dark Energy Survey (DES) supernova fields. These quasars have redshifts ranging up to 4 and have apparent AB magnitudes between 16.8 mag < r < 22.5 mag. The aim of the survey is to measure time lags between fluctuations in the quasar continuum and broad emission-line fluxes of individual objects in order to measure black hole masses for a broad range of active galactic nuclei (AGN) and constrainmore » the radius–luminosity (R–L) relationship. Here we investigate the expected efficiency of the OzDES reverberation mapping campaign and its possible extensions. We expect to recover lags for ~35–45 % of the quasars. AGN with shorter lags and greater variability are more likely to yield a lag measurement, and objects with lags ≲6 months or ~1 yr are expected to be recovered the most accurately. The baseline OzDES reverberation mapping campaign is predicted to produce an unbiased measurement of the R–L relationship parameters for Hβ, MgIIλ2798, and C IVλ1549. As a result, extending the baseline survey by either increasing the spectroscopic cadence, extending the survey season, or improving the emission-line flux measurement accuracy will significantly improve the R–L parameter constraints for all broad emission lines.« less

  5. La dysplasie fibreuse: état des lieux

    PubMed Central

    Akasbi, Nessrine; Abourazzak, Fatima Ezzahra; Talbi, Sofia; Tahiri, Latifa; Harzy, Taoufik

    2015-01-01

    La dysplasie fibreuse des os est une affection osseuse bénigne congénitale mais non héréditaire, où l'os normal est remplacé par un tissu fibreux renfermant une ostéogenèse immature. Elle est due à une mutation du gène GNAS 1sur le chromosome 20q13, une mutation activatrice de la sous-unité α de la protéine G. C'est une pathologie qui est le plus souvent silencieuse, de découverte fortuite sur une radiographie standard ou révélée par une douleur osseuse ou une fracture pathologique. L'imagerie et l'histologie, quand elle est nécessaire, permettent d’établir le diagnostic. Bien qu'il ne s'agisse pas d'une tumeur, elle est souvent classée dans la catégorie des tumeurs osseuses bénignes pour des raisons de diagnostic différentiel radiographique et anatomopathologique. Elle peut être monostotique ou polyostotique. L'approche thérapeutique est essentiellement symptomatique. Quelques publications récentes ont suggéré l'intérêt majeur d'un bisphosphonate, en particulier le pamidronate, qui diminuerait les douleurs et stimulerait une reminéralisation progressive des zones ostéolytiques chez les patients traités. D'autres traitements tels que la thérapie ciblée sont en cours d’évaluation. PMID:26401215

  6. Discovery and Classification of DES15C2kyh

    NASA Astrophysics Data System (ADS)

    Graham, M. L.; Filippenko, A. V.; Nugent, P.; Brout, D. J.; Gladney, L.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; Nichol, R.; Papadopoulos, A.; D'Andrea, C.; Smith, M.; Sullivan, M.; Childress, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Kim, A. G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Perlmutter, S.; Foley, R. J.; Casas, R.; Castander, F. J.; Desai, S.; Paech, K.; Smith, R. C.; Schubnell, M.; Kessler, R.; Lasker, J.; Scolnic, D.

    2015-10-01

    We report optical spectroscopy of DES15C2kyh discovered by the Dark Energy Survey. The spectrum (340-1025nm) was obtained using LRIS on Keck-I. Object classification was performed using superfit (Howell et al, 2005, ApJ, 634, 1190) and SNID (Blondin & Tonry, 2007, ApJ, 666, 1024), the details of which are reported in the table below.

  7. Discovery and Classification of DES15S2lam

    NASA Astrophysics Data System (ADS)

    Pan, Y.-C.; Foley, R. J.; Nichol, R.; Papadopoulos, A.; Childress, M.; D'Andrea, C.; Smith, M.; Sullivan, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Kim, A. G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Casas, R.; Castander, F. J.; Desai, S.; Paech, K.; Smith, R. C.; Schubnell, M.; Kessler, R.; Lasker, J.; Scolnic, D.; Brout, D. J.; Gladney, L.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.

    2015-10-01

    We report optical spectroscopy of DES15S2lam discovered by the Dark Energy Survey. The spectrum (540-965nm) was obtained using GMOS on Gemini-North. Object classification was performed using superfit (Howell et al, 2005, ApJ, 634, 1190) and SNID (Blondin & Tonry, 2007, ApJ, 666, 1024), the details of which are reported in the table below.

  8. Approche à l’endroit des blessures traumatiques à la main en soins primaires

    PubMed Central

    Cheung, Kevin; Hatchell, Alexandra; Thoma, Achilleas

    2013-01-01

    Résumé Objectif Passer en revue la prise en charge initiale des blessures traumatiques communes à la main que voient les médecins de soins primaires. Sources des données Nous avons examiné les données cliniques probantes et les ouvrages spécialisés récents cernés par des recherches dans la base de données électronique MEDLINE. Nous avons utilisé l’opinion d’experts pour compléter les recommandations dans les domaines où les données scientifiques étaient rares. Message principal Les médecins de soins primaires sont couramment appelés à prendre en charge des patients victimes de blessures traumatiques à la main. Dans le contexte d’un cas clinique, nous examinons l’évaluation, le diagnostic et la prise en charge initiale des traumatismes communs à la main. La présentation et la prise en charge des blessures au lit de l’ongle, des amputations de l’extrémité du doigt, des doigts en maillet, des fractures à la main, des lacérations de tendons, des morsures et de la ténosynovite infectieuse seront aussi discutées. Les principes de la prise en charge des blessures traumatiques à la main comportent la réduction et l’immobilisation des fractures, la prescription d’imagerie radiographique post-réduction, l’obtention d’un recouvrement par les tissus mous, la prévention et le traitement des infections et l’assurance d’une prophylaxie antitétanique. Conclusion Il est essentiel d’assurer une évaluation et une prise en charge appropriées des blessures traumatiques à la main pour prévenir une morbidité considérable à long terme dans une population autrement en santé. La reconnaissance sans délai des blessures qui nécessitent une demande de consultation urgente ou rapide auprès d’un chirurgien spécialiste de la main est également critique.

  9. Indirectly Estimating International Net Migration Flows by Age and Gender: The Community Demographic Model International Migration (CDM-IM) Dataset

    PubMed Central

    Nawrotzki, Raphael J.; Jiang, Leiwen

    2015-01-01

    Although data for the total number of international migrant flows is now available, no global dataset concerning demographic characteristics, such as the age and gender composition of migrant flows exists. This paper reports on the methods used to generate the CDM-IM dataset of age and gender specific profiles of bilateral net (not gross) migrant flows. We employ raw data from the United Nations Global Migration Database and estimate net migrant flows by age and gender between two time points around the year 2000, accounting for various demographic processes (fertility, mortality). The dataset contains information on 3,713 net migrant flows. Validation analyses against existing data sets and the historical, geopolitical context demonstrate that the CDM-IM dataset is of reasonably high quality. PMID:26692590

  10. Infections fongiques des brûlé : revue

    PubMed Central

    Arnould, JF.; Le Floch, R.

    2015-01-01

    Summary Les infections fongiques locales ou générales sont souvent d’une extrême gravité chez les brûlés. Les brûlés combinent de nombreux facteurs de risque à une immunodépression induite par la brûlure. Les infections de plaies sont le fait des genres Candida, Aspergillus et des agents de mucormycoses. Ces deux derniers cas sont à l’origine de lésions particulièrement sévères. Leur diagnostic repose sur la biopsie cutanée avec examens mycologique et anatomopathologique. Le traitement est essentiellement chirurgical, associé à une antibiothérapie adaptée. Les septicémies sont le fait de levures, essentiellement du genre Candida. Le diagnostic en est difficile dans le contexte des brûlés et repose souvent sur une forte suspicion clinique. Leur traitement repose sur les échinocandines et plus secondairement sur le fluconazole. PMID:26668558

  11. CMB lensing tomography with the DES Science Verification galaxies

    DOE PAGESBeta

    Giannantonio, T.

    2016-01-07

    We measure the cross-correlation between the galaxy density in the Dark Energy Survey (DES) Science Verification data and the lensing of the cosmic microwave background (CMB) as reconstructed with the Planck satellite and the South Pole Telescope (SPT). When using the DES main galaxy sample over the full redshift range 0.2 < zphot < 1.2, a cross-correlation signal is detected at 6σ and 4σ with SPT and Planck respectively. We then divide the DES galaxies into five photometric redshift bins, finding significant (>2σ) detections in all bins. Comparing to the fiducial Planck cosmology, we find the redshift evolution of themore » signal matches expectations, although the amplitude is consistently lower than predicted across redshift bins. We test for possible systematics that could affect our result and find no evidence for significant contamination. Finally, we demonstrate how these measurements can be used to constrain the growth of structure across cosmic time. We find the data are fit by a model in which the amplitude of structure in the z < 1.2 universe is 0.73 ± 0.16 times as large as predicted in the LCDM Planck cosmology, a 1.7σ deviation.« less

  12. CMB lensing tomography with the DES Science Verification galaxies

    NASA Astrophysics Data System (ADS)

    Giannantonio, T.; Fosalba, P.; Cawthon, R.; Omori, Y.; Crocce, M.; Elsner, F.; Leistedt, B.; Dodelson, S.; Benoit-Lévy, A.; Gaztañaga, E.; Holder, G.; Peiris, H. V.; Percival, W. J.; Kirk, D.; Bauer, A. H.; Benson, B. A.; Bernstein, G. M.; Carretero, J.; Crawford, T. M.; Crittenden, R.; Huterer, D.; Jain, B.; Krause, E.; Reichardt, C. L.; Ross, A. J.; Simard, G.; Soergel, B.; Stark, A.; Story, K. T.; Vieira, J. D.; Weller, J.; Abbott, T.; Abdalla, F. B.; Allam, S.; Armstrong, R.; Banerji, M.; Bernstein, R. A.; Bertin, E.; Brooks, D.; Buckley-Geer, E.; Burke, D. L.; Capozzi, D.; Carlstrom, J. E.; Carnero Rosell, A.; Carrasco Kind, M.; Castander, F. J.; Chang, C. L.; Cunha, C. E.; da Costa, L. N.; D'Andrea, C. B.; DePoy, D. L.; Desai, S.; Diehl, H. T.; Dietrich, J. P.; Doel, P.; Eifler, T. F.; Evrard, A. E.; Neto, A. Fausti; Fernandez, E.; Finley, D. A.; Flaugher, B.; Frieman, J.; Gerdes, D.; Gruen, D.; Gruendl, R. A.; Gutierrez, G.; Holzapfel, W. L.; Honscheid, K.; James, D. J.; Kuehn, K.; Kuropatkin, N.; Lahav, O.; Li, T. S.; Lima, M.; March, M.; Marshall, J. L.; Martini, P.; Melchior, P.; Miquel, R.; Mohr, J. J.; Nichol, R. C.; Nord, B.; Ogando, R.; Plazas, A. A.; Romer, A. K.; Roodman, A.; Rykoff, E. S.; Sako, M.; Saliwanchik, B. R.; Sanchez, E.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Thaler, J.; Thomas, D.; Vikram, V.; Walker, A. R.; Wechsler, R. H.; Zuntz, J.

    2016-03-01

    We measure the cross-correlation between the galaxy density in the Dark Energy Survey (DES) Science Verification data and the lensing of the cosmic microwave background (CMB) as reconstructed with the Planck satellite and the South Pole Telescope (SPT). When using the DES main galaxy sample over the full redshift range 0.2 < zphot < 1.2, a cross-correlation signal is detected at 6σ and 4σ with SPT and Planck , respectively. We then divide the DES galaxies into five photometric redshift bins, finding significant (>2σ) detections in all bins. Comparing to the fiducial Planck cosmology, we find the redshift evolution of the signal matches expectations, although the amplitude is consistently lower than predicted across redshift bins. We test for possible systematics that could affect our result and find no evidence for significant contamination. Finally, we demonstrate how these measurements can be used to constrain the growth of structure across cosmic time. We find the data are fit by a model in which the amplitude of structure in the z < 1.2 universe is 0.73 ± 0.16 times as large as predicted in the Λ cold dark matter Planck cosmology, a 1.7σ deviation.

  13. Development of a human-specific B. thetaiotaomicron IMS/ATP assay for measuring viable human contamination in surface waters in Baja California, Mexico

    EPA Science Inventory

    Immunomagnetic separation/adenosine triphosphate (IMS/ATP) assays utilize paramagnetic beads and target-specific antibodies to isolate target organisms. Following isolation, adenosine tri-phosphate (ATP) is extracted from the target population and quantified. An inversely-couple...

  14. Enhancing Biological Analyses with Three Dimensional Field Asymmetric Ion Mobility, Low Field Drift Time Ion Mobility and Mass Spectrometry (µFAIMS/IMS-MS) Separations

    SciTech Connect

    Zhang, Xing; Ibrahim, Yehia M.; Chen, Tsung-Chi; Kyle, Jennifer E.; Norheim, Randolph V.; Monroe, Matthew E.; Smith, Richard D.; Baker, Erin Shammel

    2015-06-30

    We report the first evaluation of a platform coupling a high speed field asymmetric ion mobility spectrometry microchip (µFAIMS) with drift tube ion mobility and mass spectrometry (IMS-MS). The µFAIMS/IMS-MS platform was used to analyze biological samples and simultaneously acquire multidimensional information of detected features from the measured FAIMS compensation fields and IMS drift times, while also obtaining accurate ion masses. These separations thereby increase the overall separation power, resulting increased information content, and provide more complete characterization of more complex samples. The separation conditions were optimized for sensitivity and resolving power by the selection of gas compositions and pressures in the FAIMS and IMS separation stages. The resulting performance provided three dimensional separations, benefitting both broad complex mixture studies and targeted analyses by e.g. improving isomeric separations and allowing detection of species obscured by “chemical noise” and other interfering peaks.

  15. Die Pugwash Conferences on Science and World Affairs Ein Beispiel für erfolgreiche „Track-II-Diplomacy“ der Naturwissenschaftler im Kalten Krieg

    NASA Astrophysics Data System (ADS)

    Neuneck, Götz

    "Kein Zeitalter der Geschichte ist stärker von den Naturwissenschaften durchdrungen und abhängiger von ihnen als das 20. Jahrhundert" schreibt Eric Hobsbawn im Kapitel "Zauberer und Lehrlinge: Die Naturwissenschaften" seines Buches "Zeitalter der Extreme".

  16. Tandem overproduction and characterisation of the nuclease domain of colicin E9 and its cognate inhibitor protein Im9.

    PubMed

    Wallis, R; Reilly, A; Barnes, K; Abell, C; Campbell, D G; Moore, G R; James, R; Kleanthous, C

    1994-03-01

    We report the overproduction of the non-specific endonuclease domain of the bacterial toxin colicin E9 and its preliminary characterisation in vitro. The enzymatic colicins (61 kDa) are normally released from producing cells in a complex with their cognate inhibitors, known as the immunity proteins (9.5 kDa). Tryptic digestion of the purified ColE9 complex was found to generate two major components, a monomer derived from the N-terminal and central regions of the toxin and a heterodimer comprising the catalytically active C-terminal domain of the colicin bound to its intact immunity protein, Im9. N-terminal amino acid sequencing, in conjunction with electrospray mass spectrometry, shows that preparations of the DNase domain isolated by this method are heterogeneous, thus making subsequent mechanistic and structural analysis difficult. This problem was circumvented by selectively overexpressing the C-terminal 15-kDa nuclease domain of colicin E9 in tandem with its cognate inhibitor in Escherichia coli. This tandem overexpression strategy allowed high-level production of a 25-kDa protein complex comprising the C-terminal DNase domain of colicin E9 tightly bound to its specific inhibitor Im9, thus masking the anticipated toxicity of the nuclease. The DNase domain was then separated from Im9 under denaturing conditions, refolded by removal of the denaturant and the renatured protein shown to possess both endonuclease and Im9 binding activity. These results describe a novel method for the overproduction of a nuclease in bacteria by co-expressing its specific inhibitor and lay the foundations for a full mechanistic, biophysical and structural characterization of the isolated DNase domain of the colicin E9 toxin. PMID:8125102

  17. Singular vector based targeted observations of chemical constituents: description and first application of the EURAD-IM-SVA

    NASA Astrophysics Data System (ADS)

    Goris, N.; Elbern, H.

    2015-08-01

    Measurements of the large dimensional chemical state of the atmosphere provide only sparse snapshots of the state of the system due to their typically insufficient temporal and spatial density. In order to optimize the measurement configurations despite those limitations, the present work describes the identification of sensitive states of the chemical system as optimal target areas for adaptive observations. For this purpose, the technique of singular vector analysis (SVA), which has been proved effective for targeted observations in numerical weather predication, is implemented into the chemical transport model EURAD-IM (EURopean Air pollution and Dispersion - Inverse Model) yielding the EURAD-IM-SVA. Besides initial values, emissions are investigated as critical simulation controlling targeting variables. For both variants, singular vectors are applied to determine the optimal placement for observations and moreover to quantify which chemical compounds have to be observed with preference. Based on measurements of the airship based ZEPTER-2 campaign, the EURAD-IM-SVA has been evaluated by conducting a comprehensive set of model runs involving different initial states and simulation lengths. Since the considered cases are restricted in terms of considered chemical compounds and selected areas, they allow for a retracing of the results and a confirmation of their correctness. Our analysis shows that the optimal placement for observations of chemical species is not entirely determined by mere transport and mixing processes. Rather, a combination of initial chemical concentrations, chemical conversions, and meteorological processes determine the influence of chemical compounds and regions. We furthermore demonstrate that the optimal placement of observations of emission strengths is highly dependent on the location of emission sources and that the benefit of including emissions as target variables outperforms the value of initial value optimisation with growing

  18. Double DCO+ Rings Reveal CO Ice Desorption in the Outer Disk Around IM Lup

    NASA Astrophysics Data System (ADS)

    Öberg, Karin I.; Furuya, Kenji; Loomis, Ryan; Aikawa, Yuri; Andrews, Sean M.; Qi, Chunhua; van Dishoeck, Ewine F.; Wilner, David J.

    2015-09-01

    In a protoplanetary disk, a combination of thermal and non-thermal desorption processes regulate where volatiles are liberated from icy grain mantles into the gas phase. Non-thermal desorption should result in volatile-enriched gas in disk-regions where complete freeze-out is otherwise expected. We present Atacama Large Millimeter/Submillimeter Array observations of the disk around the young star IM Lup in 1.4 mm continuum, C18O 2–1, H13CO+ 3–2 and DCO+ 3–2 emission at ∼0.″5 resolution. The images of these dust and gas tracers are clearly resolved. The DCO+ line exhibits a striking pair of concentric rings of emission that peak at radii of ∼0.″6 and 2″ (∼90 and 300 AU, respectively). Based on disk chemistry model comparison, the inner DCO+ ring is associated with the balance of CO freeze-out and thermal desorption due to a radial decrease in disk temperature. The outer DCO+ ring is explained by non-thermal desorption of CO ice in the low-column-density outer disk, repopulating the disk midplane with cold CO gas. The CO gas then reacts with abundant H2D+ to form the observed DCO+ outer ring. These observations demonstrate that spatially resolved DCO+ emission can be used to trace otherwise hidden cold gas reservoirs in the outmost disk regions, opening a new window onto their chemistry and kinematics.

  19. The primary transcriptome of the marine diazotroph Trichodesmium erythraeum IMS101

    PubMed Central

    Pfreundt, Ulrike; Kopf, Matthias; Belkin, Natalia; Berman-Frank, Ilana; Hess, Wolfgang R.

    2014-01-01

    Blooms of the dinitrogen-fixing marine cyanobacterium Trichodesmium considerably contribute to new nitrogen inputs into tropical oceans. Intriguingly, only 60% of the Trichodesmium erythraeum IMS101 genome sequence codes for protein, compared with ~85% in other sequenced cyanobacterial genomes. The extensive non-coding genome fraction suggests space for an unusually high number of unidentified, potentially regulatory non-protein-coding RNAs (ncRNAs). To identify the transcribed fraction of the genome, here we present a genome-wide map of transcriptional start sites (TSS) at single nucleotide resolution, revealing the activity of 6,080 promoters. We demonstrate that T. erythraeum has the highest number of actively splicing group II introns and the highest percentage of TSS yielding ncRNAs of any bacterium examined to date. We identified a highly transcribed retroelement that serves as template repeat for the targeted mutation of at least 12 different genes by mutagenic homing. Our findings explain the non-coding portion of the T. erythraeum genome by the transcription of an unusually high number of non-coding transcripts in addition to the known high incidence of transposable elements. We conclude that riboregulation and RNA maturation-dependent processes constitute a major part of the Trichodesmium regulatory apparatus. PMID:25155278

  20. The primary transcriptome of the marine diazotroph Trichodesmium erythraeum IMS101

    NASA Astrophysics Data System (ADS)

    Pfreundt, Ulrike; Kopf, Matthias; Belkin, Natalia; Berman-Frank, Ilana; Hess, Wolfgang R.

    2014-08-01

    Blooms of the dinitrogen-fixing marine cyanobacterium Trichodesmium considerably contribute to new nitrogen inputs into tropical oceans. Intriguingly, only 60% of the Trichodesmium erythraeum IMS101 genome sequence codes for protein, compared with ~85% in other sequenced cyanobacterial genomes. The extensive non-coding genome fraction suggests space for an unusually high number of unidentified, potentially regulatory non-protein-coding RNAs (ncRNAs). To identify the transcribed fraction of the genome, here we present a genome-wide map of transcriptional start sites (TSS) at single nucleotide resolution, revealing the activity of 6,080 promoters. We demonstrate that T. erythraeum has the highest number of actively splicing group II introns and the highest percentage of TSS yielding ncRNAs of any bacterium examined to date. We identified a highly transcribed retroelement that serves as template repeat for the targeted mutation of at least 12 different genes by mutagenic homing. Our findings explain the non-coding portion of the T. erythraeum genome by the transcription of an unusually high number of non-coding transcripts in addition to the known high incidence of transposable elements. We conclude that riboregulation and RNA maturation-dependent processes constitute a major part of the Trichodesmium regulatory apparatus.

  1. The long-period RS CVn binary IM Pegasi --- II. First surface images

    NASA Astrophysics Data System (ADS)

    Berdyugina, S. V.; Berdyugin, A. V.; Ilyin, I.; Tuominen, I.

    2000-08-01

    New high-resolution, high signal-to-noise ratio spectroscopic observations and UBV photometry carried out in 1996-1999 were analysed with the surface imaging technique. A total of 8 images of IM Peg was obtained for the first time. A huge high-latitude active region was found to dominate the stellar surface and decreased in area during the period of the observations. At the same time, on the opposite hemisphere (in longitudes), smaller spots were developing. The spots were migrating in the orbital reference frame, the period of spot rotation being of 24.d73∓0.d02. The spots constitute two active longitudes on opposite stellar hemispheres, similar to other RS CVn stars. The evolution of the spot areas within the active longitudes indicates a stellar activity cycle, during which one active longitude dominates the stellar activity, to be about 6.5 years. Then, a total cycle, comprising two consecutive periods of activity of both active longitudes, is about 13 years. In 1999, the activity switched to the other active longitude. This declared the beginning of a new (half-) cycle. based on observations collected at the Nordic Optical Telescope (NOT), La Palma, Spain; the 2.6 m and 1.25 m telescopes of the Crimean Astrophysical Observatory, Ukraine; the 2m telescope of the National Astronomical Observatory, Rozhen, Bulgaria.

  2. Time reversed test particle calculations at Titan, based on CAPS-IMS measurements

    NASA Astrophysics Data System (ADS)

    Bebesi, Zsofia; Erdos, Geza; Szego, Karoly; Young, David T.

    2013-04-01

    We used the theoretical approach of Kobel and Flückiger (1994) to construct a magnetic environment model in the vicinity of Titan - with the exception of placing the bow shock (which is not present at Titan) into infinity. The model has 4 free parameters to calibrate the shape and orientation of the field. We investigate the CAPS-IMS Singles data to calculate/estimate the location of origin of the detected cold ions at Titan, and we also use the measurements of the onboard Magnetometer to set the parameters of the model magnetic field. A 4th order Runge-Kutta method is applied to calculate the test particle trajectories in a time reversed scenario, in the curved magnetic environment. Several different ion species can be tracked by the model along their possible trajectories, as a first approach we considered three particle groups (1, 2 and 16 amu ions). In this initial study we show the results for some thoroughly discussed flybys like TA, TB and T5, but we consider more recent tailside encounters as well. Reference: Kobel, E. and E.O. Flückiger, A model of the steady state magnetic field in the magnetosheath, JGR 99, Issue A12, 23617, 1994

  3. Proposed IMS infrastructure improvement project, Seward, Alaska. Final environmental impact statement

    SciTech Connect

    Not Available

    1994-09-01

    This Environmental Impact Statement (EIS) examines a proposal for improvements at the existing University of Alaska, Fairbanks, Institute of Marine Science (IMS), Seward Marine Center. The Exxon Valdez Oil Spill (EVOS) Trustee Council is proposing to improve the existing research infrastructure to enhance the EVOS Trustee Council`s capabilities to study and rehabilitate marine mammals, marine birds, and the ecosystem injured by the Exxon Valdez oil spill. The analysis in this document focuses on the effects associated with construction and operation of the proposed project and its proposed alternatives. The EIS gives a detailed description of all major elements of the proposed project and its alternatives; identifies resources of major concern that were raised during the scoping process; describes the environmental background conditions of those resources; defines and analyzes the potential effects of the proposed project and its alternatives on these conditions; and identifies mitigating measures that are part of the project design as well as those proposed to minimize or reduce the adverse effects. Included in the EIS are written and oral comments received during the public comment period.

  4. Physical aging effects on the compressive linear viscoelastic creep of IM7/K3B composite

    NASA Technical Reports Server (NTRS)

    Veazie, David R.; Gates, Thomas S.

    1995-01-01

    An experimental study was undertaken to establish the viscoelastic behavior of 1M7/K3B composite in compression at elevated temperature. Creep compliance, strain recovery and the effects of physical aging on the time dependent response was measured for uniaxial loading at several isothermal conditions below the glass transition temperature (T(g)). The IM7/K3B composite is a graphite reinforced thermoplastic polyimide with a T(g) of approximately 240 C. In a composite, the two matrix dominated compliance terms associated with time dependent behavior occur in the transverse and shear directions. Linear viscoelasticity was used to characterize the creep/recovery behavior and superposition techniques were used to establish the physical aging related material constants. Creep strain was converted to compliance and measured as a function of test time and aging time. Results included creep compliance master curves, physical aging shift factors and shift rates. The description of the unique experimental techniques required for compressive testing is also given.

  5. ``Chemie im Kontext'': A symbiotic implementation of a context-based teaching and learning approach

    NASA Astrophysics Data System (ADS)

    Parchmann, Ilka; Gräsel, Cornelia; Baer, Anja; Nentwig, Peter; Demuth, Reinhard; Ralle, Bernd

    2006-07-01

    “Chemie im Kontext” (ChiK) is a project that aims at the improvement of chemistry teaching at secondary school in Germany. Based on a framework that was derived from theories and empirical data on the teaching and learning of science, science education researchers and teachers work together on learning communities to transform this framework into teaching and learning practice. Funded by the German Federal Ministry of Education and the participating federal states, such learning communities have developed and tried units for almost all topics for upper and lower secondary education. The accompanying research studies show different effects on students’ motivation: The ChiK units point out the relevance of chemistry, but the student-oriented learning approach can also lead to a feeling of getting lost in the context. One reason might be seen in the result that teachers have put more emphasis on the realization of a good context than on the second important principle of ChiK—the development of basic concepts. However, data also showed that the learning communities have indeed inspired and supported the teachers to change their teaching towards a more context-based and student-oriented teaching. The continuing work will now especially focus on the improvement of facilitating the students with a better guideline, and on the development and assessment of different science competencies.

  6. High strain rate mechanical properties of IM7/8551-7 graphite epoxy composite

    SciTech Connect

    Powers, B.M.; Vinson, J.R.; Hall, I.W.

    1995-12-31

    Polymer matrix composites offer excellent mechanical properties such as high specific strength and stiffness which make them attractive for many naval, aerospace and automotive structural components. Although they are candidate materials for many applications where high strain rate loading is probable, little is known of the material responses to shock loading for most composite materials. Because mechanical properties vary significantly with strain rate, the use of static properties in the analysis and design of structures which undergo dynamic loadings can on one hand lead to a very conservative overweight design, or on the other hand can lead to designs which fail prematurely and unexpectedly. The use of dynamic material properties will ensure the design of composite structures which are weight efficient and structurally sound when they are subjected to dynamic loads. In this study, a Split Hopkinson Pressure Bar is used to obtain compressive mechanical properties of a unidirectional IM7/8551-7 graphite epoxy composite. For each of the three principal directions, the yield stress, yield strain, ultimate stress, ultimate strain, modulus of elasticity, elastic strain energy function and the total strain energy to failure are presented for strain rates varying from 49 sec{sup {minus}1} to 1430 sec{sup {minus}1}. The data from 72 tests are statistically analyzed, represented by equations, and discussed in some detail.

  7. Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing

    NASA Astrophysics Data System (ADS)

    Both, P.; Green, A. P.; Gray, C. J.; Šardzík, R.; Voglmeir, J.; Fontana, C.; Austeri, M.; Rejzek, M.; Richardson, D.; Field, R. A.; Widmalm, G.; Flitsch, S. L.; Eyers, C. E.

    2014-01-01

    Mass spectrometry is the primary analytical technique used to characterize the complex oligosaccharides that decorate cell surfaces. Monosaccharide building blocks are often simple epimers, which when combined produce diastereomeric glycoconjugates indistinguishable by mass spectrometry. Structure elucidation frequently relies on assumptions that biosynthetic pathways are highly conserved. Here, we show that biosynthetic enzymes can display unexpected promiscuity, with human glycosyltransferase pp-α-GanT2 able to utilize both uridine diphosphate N-acetylglucosamine and uridine diphosphate N-acetylgalactosamine, leading to the synthesis of epimeric glycopeptides in vitro. Ion-mobility mass spectrometry (IM-MS) was used to separate these structures and, significantly, enabled characterization of the attached glycan based on the drift times of the monosaccharide product ions generated following collision-induced dissociation. Finally, ion-mobility mass spectrometry following fragmentation was used to determine the nature of both the reducing and non-reducing glycans of a series of epimeric disaccharides and the branched pentasaccharide Man3 glycan, demonstrating that this technique may prove useful for the sequencing of complex oligosaccharides.

  8. The Hummingbird GC-IMS: In Situ Analysis of a Cometary Nucleus

    NASA Technical Reports Server (NTRS)

    Kojiro, Daniel R.; Carle, Glenn C.; Cohen, Martin J.; Wernlund, Roger F.; Stimac, Robert M.; Takeuchi, Norishige; DeVincenzi, Donald L. (Technical Monitor)

    2000-01-01

    Comets are of enormous scientific interest for many reasons. They are primitive bodies that date back to the earliest stages of solar system formation and, because of their small size and because they have been stored in the outer reaches of the solar system, their pristine nature has been preserved better than for any other class of body. They are extremely rich in highly volatile elements, many in the form of ices, and are richer in organic matter than any other known solar system body. It is strongly suspected that in addition to their content of primordial solar nebular material, they also incorporate unprocessed matter from the interstellar medium. Impacts by comets occur onto all the planets and satellites, often with major consequences (e.g., the dinosaur extinction event at the KIT boundary), or sometimes just providing a spectacular cosmic event (e.g., the collision of comet Shoemaker-Levy 9 with Jupiter). A mission to analyze a cometary nucleus must be capable of detecting and identifying over 30 molecular species among several different chemical groups. The Hummingbird Mission will rendezvous with, orbit, characterize, and make multiple descents to the nucleus of a comet. Hummingbird will employ a Gas Chromatograph - Ion Mobility Spectrometer (GC-IMS) as part-of a suite of sophisticated instruments for a comprehensive in situ elemental, molecular, and isotopic analysis of the comet.

  9. Agent-Based Support for Context-Aware Provisioning of IMS-Enabled Ubiquitous Services

    NASA Astrophysics Data System (ADS)

    Petric, Ana; Trzec, Krunoslav; Jurasovic, Kresimir; Podobnik, Vedran; Jezic, Gordan; Kusek, Mario; Ljubi, Igor

    Multimedia applications executed on mobile devices allow users to be present and communicate with other users, anywhere and anytime, through wide area cellular networks, wireless local area networks (WLAN), or fixed networks. In order to enable ubiquitous personalized services, communication systems should allow users to specify their context, or their mobile devices and network infrastructures should automatically sense their context and offer enhanced service provisioning solutions. In this paper, we propose an agent-based solution that supports context-aware provisioning of IP multimedia subsystem (IMS)-enabled ubiquitous services. Using agent technology, multimedia communication, controlled by SIP and enriched with context-related events delivered by SIP's event mechanism, can be seamlessly provisioned, taking into account not only mobility issues and context-awareness, but also the semantics of exchanged events. This paper proposes a multi-agent system that will enable users to consume context-aware ubiquitous services in a seamless (i.e., automated) way, providing optimal provisioning of SIP-based multimedia services according to user preferences.

  10. IMGT®, the international ImMunoGeneTics information system® 25 years on

    PubMed Central

    Lefranc, Marie-Paule; Giudicelli, Véronique; Duroux, Patrice; Jabado-Michaloud, Joumana; Folch, Géraldine; Aouinti, Safa; Carillon, Emilie; Duvergey, Hugo; Houles, Amélie; Paysan-Lafosse, Typhaine; Hadi-Saljoqi, Saida; Sasorith, Souphatta; Lefranc, Gérard; Kossida, Sofia

    2015-01-01

    IMGT®, the international ImMunoGeneTics information system®(http://www.imgt.org) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT® is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH) and proteins of the IgSF and MhSF superfamilies. IMGT® is built on the IMGT-ONTOLOGY axioms and concepts, which bridged the gap between genes, sequences and 3D structures. The concepts include the IMGT® standardized keywords (identification), IMGT® standardized labels (description), IMGT® standardized nomenclature (classification), IMGT unique numbering and IMGT Colliers de Perles (numerotation). IMGT® comprises 7 databases, 17 online tools and 15 000 pages of web resources, and provides a high-quality and integrated system for analysis of the genomic and expressed IG and TR repertoire of the adaptive immune responses, including NGS high-throughput data. Tools and databases are used in basic, veterinary and medical research, in clinical applications (mutation analysis in leukemia and lymphoma) and in antibody engineering and humanization. The IMGT/mAb-DB interface was developed for therapeutic antibodies and fusion proteins for immunological applications (FPIA). IMGT® is freely available at http://www.imgt.org. PMID:25378316

  11. IMGT®, the international ImMunoGeneTics information system® 25 years on.

    PubMed

    Lefranc, Marie-Paule; Giudicelli, Véronique; Duroux, Patrice; Jabado-Michaloud, Joumana; Folch, Géraldine; Aouinti, Safa; Carillon, Emilie; Duvergey, Hugo; Houles, Amélie; Paysan-Lafosse, Typhaine; Hadi-Saljoqi, Saida; Sasorith, Souphatta; Lefranc, Gérard; Kossida, Sofia

    2015-01-01

    IMGT(®), the international ImMunoGeneTics information system(®)(http://www.imgt.org) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT(®) marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT(®) is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH) and proteins of the IgSF and MhSF superfamilies. IMGT(®) is built on the IMGT-ONTOLOGY axioms and concepts, which bridged the gap between genes, sequences and 3D structures. The concepts include the IMGT(®) standardized keywords (identification), IMGT(®) standardized labels (description), IMGT(®) standardized nomenclature (classification), IMGT unique numbering and IMGT Colliers de Perles (numerotation). IMGT(®) comprises 7 databases, 17 online tools and 15,000 pages of web resources, and provides a high-quality and integrated system for analysis of the genomic and expressed IG and TR repertoire of the adaptive immune responses, including NGS high-throughput data. Tools and databases are used in basic, veterinary and medical research, in clinical applications (mutation analysis in leukemia and lymphoma) and in antibody engineering and humanization. The IMGT/mAb-DB interface was developed for therapeutic antibodies and fusion proteins for immunological applications (FPIA). IMGT(®) is freely available at http://www.imgt.org. PMID:25378316

  12. Giotto IMS measurements of the production rate of hydrogen cyanide in the coma of Comet Halley

    NASA Technical Reports Server (NTRS)

    Ip, W.-H.; Balsiger, H.; Geiss, J.; Goldstein, B. E.; Kettmann, G.

    1990-01-01

    The ion composition measurements in the ionosphere of Comet Halley by the ion mass spectrometer (IMS) experiment on the Giotto spacecraft are used to estimate the relative abundance of HCN. From a comparison of the normalized number density of ions with mass-to-charge (M/q) ratio of 28 AMU/e with steady-state photochemical models, it can be determined that the production rate of HCN directly from the central nucleus is Q(HCN) is less than about 0.0002 Q(H2O) at the time of Giotto encounter. The related photochemical- model calculations also indicate that Q(NH3)/Q(H2O) at the time of Giotto encounter. The related photo-chemical model calculations also indicate that Q(HN3)/Q(H2O) equals about 0.005, in agreement with recent determination from ground-based observations. The estimated value of Q(HCN) is lower than the relative abundance of Q(HCN)/Q(H2O) of about 0.001, as derived from radio observations of the 88.6 GHz emission of the J = 1 - 0 transition of HCN. The difference may be the result of time variations of the coma composition and dynamics, as well as other model-dependent effects.

  13. Automated Fiber Placement of PEEK/IM7 Composites with Film Interleaf Layers

    NASA Technical Reports Server (NTRS)

    Hulcher, A. Bruce; Banks, William I., III; Pipes, R. Byron; Tiwari, Surendra N.; Cano, Roberto J.; Johnston, Norman J.; Clinton, R. G., Jr. (Technical Monitor)

    2001-01-01

    The incorporation of thin discrete layers of resin between plies (interleafing) has been shown to improve fatigue and impact properties of structural composite materials. Furthermore, interleafing could be used to increase the barrier properties of composites used as structural materials for cryogenic propellant storage. In this work, robotic heated-head tape placement of PEEK/IM7 composites containing a PEEK polymer film interleaf was investigated. These experiments were carried out at the NASA Langley Research Center automated fiber placement facility. Using the robotic equipment, an optimal fabrication process was developed for the composite without the interleaf. Preliminary interleaf processing trials indicated that a two-stage process was necessary; the film had to be tacked to the partially-placed laminate then fully melted in a separate operation. Screening experiments determined the relative influence of the various robotic process variables on the peel strength of the film-composite interface. Optimization studies were performed in which peel specimens were fabricated at various compaction loads and roller temperatures at each of three film melt processing rates. The resulting data were fitted with quadratic response surfaces. Additional specimens were fabricated at placement parameters predicted by the response surface models to yield high peel strength in an attempt to gage the accuracy of the predicted response and assess the repeatability of the process. The overall results indicate that quality PEEK/lM7 laminates having film interleaves can be successfully and repeatability fabricated by heated head automated fiber placement.

  14. IMGT, the international ImMunoGeneTics information system, http://imgt.cines.fr.

    PubMed

    Lefranc, Marie-Paule

    2003-01-01

    IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr), is a high quality integrated knowledge resource specializing in immunoglobulins (IG), T cell receptors (TR) and major histocompatibility complexes (MHC) and related proteins of the immune system (RPI) of human and other vertebrates, created in 1989 by LIGM at the Université Montpellier II, CNRS, Montpellier, France. IMGT provides a common access to standardized data which include nucleotide and protein sequences, oligonucleotide primers, gene maps, genetic polymorphisms, specificities, and 2D and 3D structures. IMGT includes five databases (IMGT/LIGM-DB, IMGT/3Dstructure-DB, IMGT/MHC-DB, IMGT/PRIMER-DB, IMGT/GENE-DB) Web resources ('IMGT Marie-Paule page') and interactive tools (IMGT/V-QUEST, IMGT/JunctionAnalysis, IMGT/PhyloGene, IMGT/LocusView, IMGT/GeneView, IMGT/GeneSearch, IMGT/StructureQuery). IMGT data are expertly annotated according to the rules of the IMGT Scientific chart based on IMGTONTOLOGY. IMGT tools are particularly useful for the analysis of the IG and TR repertoires in physiological normal and pathological situations. IMGT has important applications in medical research (autoimmune diseases, AIDS, leukaemias, lymphomas, myelomas), biotechnology related to antibody engineering (phage displays, combinatorial libraries) and therapeutic approaches (graft, immunotherapy). IMGT is freely available at http://imgt.cines.fr. PMID:14712935

  15. Analytical formulation of directly modulated OOFDM signals transmitted over an IM/DD dispersive link.

    PubMed

    Sánchez, C; Ortega, B; Wei, J L; Tang, J; Capmany, J

    2013-03-25

    We provide an analytical study on the propagation effects of a directly modulated OOFDM signal through a dispersive fiber and subsequent photo-detection. The analysis includes the effects of the laser operation point and the interplay between chromatic dispersion and laser chirp. The final expression allows to understand the physics behind the transmission of a multi-carrier signal in the presence of residual frequency modulation and the description of the induced intermodulation distortion gives us a detailed insight into the diferent intermodulation products which impair the recovered signal at the receiver-end side. Numerical comparisons between transmission simulations results and those provided by evaluating the expression obtained are carried out for different laser operation points. Results obtained by changing the fiber length, laser parameters and using single mode fiber with negative and positive dispersion are calculated in order to demonstrate the validity and versatility of the theory provided in this paper. Therefore, a novel analytical formulation is presented as a versatile tool for the description and study of IM/DD OOFDM systems with variable design parameters. PMID:23546148

  16. Annuaire du bureau des Longitudes : guide de données astronomiques 2011 pour l'observation du ciel

    NASA Astrophysics Data System (ADS)

    Institut de Mécanique Céleste Et de Calcul Des Ephémérides (Imcce); Bureau Des Longitudes (Bdl)

    2010-07-01

    Destiné aux astronomes, professionnels ou amateurs, cet ouvrage se décompose de la façon suivante : Les trois premiers chapitres de cet ouvrage contiennent : les données sur les différents calendriers et leur concordance, les fêtes légales en France, les différentes échelles de temps, les dates de décrets sur les heures légales en France métropolitaine parues au Journal Officiel depuis 1916 ; des notions nécessaires à la compréhension et à l'emploi des éphémérides contenues dans l'ouvrage. Les chapitres suivant fournissent des éphémérides astronomiques : les positions du Soleil et de la Lune ; les positions des planètes et de leurs satellites ; les positions des astéroïdes et des comètes ; les explications et des données pour l'observation de la surface du Soleil, de la Lune et des planètes ; des cartes du ciel, une liste de constellations et les positions et occultations des étoiles ; des données sur les éclipses de Soleil et de Lune et sur les phénomènes astronomiques ; la liste des observatoires astronomiques les plus connus.

  17. Annuaire du bureau des Longitudes : guide de données astronomiques 2012 pour l'observation du ciel

    NASA Astrophysics Data System (ADS)

    Institut de Mécanique Céleste Et de Calcul Des Ephémérides (Imcce); Bureau Des Longitudes (Bdl)

    2011-07-01

    Destiné aux astronomes, professionnels ou amateurs, cet ouvrage se décompose de la façon suivante : Les trois premiers chapitres de cet ouvrage contiennent : les données sur les différents calendriers et leur concordance, les fêtes légales en France, les différentes échelles de temps, les dates de décrets sur les heures légales en France métropolitaine parues au Journal Officiel depuis 1916 ; des notions nécessaires à la compréhension et à l'emploi des éphémérides contenues dans l'ouvrage. Les chapitres suivant fournissent des éphémérides astronomiques : les positions du Soleil et de la Lune ; les positions des planètes et de leurs satellites ; les positions des astéroïdes et des comètes ; les explications et des données pour l'observation de la surface du Soleil, de la Lune et des planètes ; des cartes du ciel, une liste de constellations et les positions et occultations des étoiles ; des données sur les éclipses de Soleil et de Lune et sur les phénomènes astronomiques ; la liste des observatoires astronomiques les plus connus.

  18. Que peut-on voir avec des neutrons? Une introduction pour des non spécialistes

    NASA Astrophysics Data System (ADS)

    Schweizer, J.

    2005-11-01

    Le neutron est une particule élémentaire qui a été découverte en 1932 par James Chadwick. Ses caractéristiques principales sont résumées dans le tableau I. Il a été utilisé pour la première fois par Clifford Shull en 1946 comme outil pour des expériences de diffusion. Cette technique s'est depuis constamment développée pour concerner tous les aspects de la matière condensée: physique, chimie, matériaux, biologie. Il s'agit d'un outil tout à fait exceptionnel car le neutron possède des propriétés uniques et particulièrement adaptées pour ces études.

  19. Superfund Record of Decision (EPA Region 7): Des Moines TCE, Des Moines, Polk County, Iowa, July 1986. Final report

    SciTech Connect

    Not Available

    1986-07-21

    The Des Moines TCE site includes the underground infiltration gallery used by the Des Moines Water Works (DMWW) as a source of the public water supply. The site was discovered in 1984 after trichloroethylene (TCE) was detected in the city's public water supply. The Dico Company disposed of an unknown quantity of oily waste sludge containing TCE onto their parking lot for dust control and into a drainage ditch on their property. The primary contaminants of concern include: TCE, PCE, 1,2-dichloroethane, vinyl chloride. The selected remedial action for this site includes: extraction wells to collect the contaminated ground water; isolation of the northern-most section of the north gallery; treatment of the ground water through air stripping to remove 96% of the TCE; discharge of the treated water to the Raccoon River; operation of the west extraction wells until established effluent levels are achieved for four consecutive months.

  20. Study of Out-Time on the Processing and Properties of IM7/977-3 Composites

    NASA Technical Reports Server (NTRS)

    Miller, Sandi G.; Sutter, James K.; Scheiman, Daniel A.; Maryanski, Michael; Schlea, Michelle

    2010-01-01

    The capability to manufacture large structures leads to weight savings and reduced risk relative to joining smaller components. However, manufacture of increasingly large composite components is pushing the out-life limits of epoxy/ carbon fiber prepreg. IM7/977-3 is an autoclave processable prepreg material, commonly used in aerospace structures. The out-life limit is reported as 30 days by the manufacturer. The purpose of this work was to evaluate the material processability and composite properties of 977-3 resin and IM7/977-3 prepreg that had been aged at room temperature for up to 60 days. The neat resin was evaluated by differential scanning calorimetry, DSC, to characterize cure behavior of the aged material, as well as any change in activation energy. The rise in the modulus of the uncured prepreg was monitored throughout the 60 days by dynamic mechanical analysis, DMA. Composite panels made of the fresh and aged prepreg material were also characterized by DMA. The overall test results suggested that IM7/977-3 was a robust material that offered quality laminates throughout this aging process when processed by autoclave.

  1. Post-installation activities in the Comprehensive Nuclear Test Ban Treaty (CTBT) International Monitoring System (IMS) infrasound network

    NASA Astrophysics Data System (ADS)

    Vivas Veloso, J. A.; Christie, D. R.; Hoffmann, T. L.; Campus, P.; Bell, M.; Langlois, A.; Martysevich, P.; Demirovik, E.; Carvalho, J.; Kramer, A.; Wu, Sean F.

    2002-11-01

    The provisional operation and maintenance of IMS infrasound stations after installation and subsequent certification has the objective to prepare the infrasound network for entry into force of the Comprehensive Nuclear-Test-Ban Treaty (CTBT). The goal is to maintain and fine tune the technical capabilities of the network, to repair faulty equipment, and to ensure that stations continue to meet the minimum specifications through evaluation of data quality and station recalibration. Due to the globally dispersed nature of the network, this program constitutes a significant undertaking that requires careful consideration of possible logistic approaches and their financial implications. Currently, 11 of the 60 IMS infrasound stations are transmitting data in the post-installation Testing & Evaluation mode. Another 5 stations are under provisional operation and are maintained in post-certification mode. It is expected that 20% of the infrasound network will be certified by the end of 2002. This presentation will focus on the different phases of post-installation activities of the IMS infrasound program and the logistical challenges to be tackled to ensure a cost-efficient management of the network. Specific topics will include Testing & Evaluation and Certification of Infrasound Stations, as well as Configuration Management and Network Sustainment.

  2. Analytical/Operational Requirements for the In Situ Chemical Analysis of Cometary and Planetary Environments Using GC-IMS

    NASA Technical Reports Server (NTRS)

    Kojiro, Daniel R.; Stimac, Robert M.; Kaye, William J.; Takeuchi, Norishige; DeVincenizi, D. (Technical Monitor)

    2002-01-01

    Exobiology flight experiments require highly sensitive instrumentation for the in situ analysis of the volatile chemical species that occur in the atmospheres and surfaces of various bodies within the solar system. The complex mixtures encountered place a heavy burden on the analytical instrumentation to detect and identify all species present. The minimal resources available onboard for such missions mandate that the instruments provide maximum analytical capabilities with minimal requirements of volume, weight and consumables. The miniCIDEX instrument was developed for the chemical analysis of a cemetery environment. It combined a Gas Chromatograph (GC) with a helium based Ion Mobility Spectrometer (IMS) to fulfill the analytical requirements of a cemetery exobiology mission: universal response; ppb sensitivity; low mass, volume and consumable MiniCIDEX is now a candidate for the chemical analysis instrument of a Titan Aero-rover Mission. The complexity of the analyses will be similar to the comet application with a heavier emphasis on organic molecules. Because the Titan Aero-Rover will be a balloon powered rover, much more attention is placed on the total mass of the instrument package. The GC will likely be a Micro-Electro-Mechanical-System (MEMS) design, smaller than the initial miniCIDEX GC by a factor of ten (with a similar reduction in consumable use). Similar miniaturization of the helium-based IMS will be necessary while maintaining the analytical capabilities. The two mission applications, the analytical requirements, and the evolution of the IMS design to accommodate these requirements will be presented.

  3. IM-16: A new microporous germanosilicate with a novel framework topology containing d4r and mtw composite building units

    SciTech Connect

    Lorgouilloux, Yannick; Dodin, Mathias; Paillaud, Jean-Louis Caullet, Philippe; Michelin, Laure; Josien, Ludovic; Ersen, Ovidiu; Bats, Nicolas

    2009-03-15

    The synthesis and the structure of IM-16 a new germanosilicate with a novel zeolitic topology prepared hydrothermally with the ionic liquid 3-ethyl-1-methyl-3H-imidazol-1-ium as the organic structure-directing agent are reported. The structure of calcined and partially rehydrated IM-16 of chemical formula |(H{sub 2}O){sub 0.16}|[Si{sub 3.47}Ge{sub 2.53}O{sub 12}] was solved from powder XRD data in space group Cmcm with a=15.0861(2) A, b=17.7719(3) A, c=19.9764(3) A, V=5355.84(12) A{sup 3} (Z=16). This new zeolite framework type contains 10-MRs channels and may be described from the d4r and mtw composite building units. - Graphical abstract: The synthesis and the structure of IM-16 a new germanosilicate with a novel zeolitic topology prepared hydrothermally with the ionic liquid 3-ethyl-1-methyl-3H-imidazol-1-ium as the organic structure-directing agent are reported. This new zeolite framework type contains 10-MRs channels and may be described from the d4r and mtw composite building units.

  4. imFASP: An integrated approach combining in-situ filter-aided sample pretreatment with microwave-assisted protein digestion for fast and efficient proteome sample preparation.

    PubMed

    Zhao, Qun; Fang, Fei; Wu, Ci; Wu, Qi; Liang, Yu; Liang, Zhen; Zhang, Lihua; Zhang, Yukui

    2016-03-17

    An integrated sample preparation method, termed "imFASP", which combined in-situ filter-aided sample pretreatment and microwave-assisted trypsin digestion, was developed for preparation of microgram and even nanogram amounts of complex protein samples with high efficiency in 1 h. For imFASP method, proteins dissolved in 8 M urea were loaded onto a filter device with molecular weight cut off (MWCO) as 10 kDa, followed by in-situ protein preconcentration, denaturation, reduction, alkylation, and microwave-assisted tryptic digestion. Compared with traditional in-solution sample preparation method, imFASP method generated more protein and peptide identifications (IDs) from preparation of 45 μg Escherichia coli protein sample due to the higher efficiency, and the sample preparation throughput was significantly improved by 14 times (1 h vs. 15 h). More importantly, when the starting amounts of E. coli cell lysate decreased to nanogram level (50-500 ng), the protein and peptide identified by imFASP method were improved at least 30% and 44%, compared with traditional in-solution preparation method, suggesting dramatically higher peptide recovery of imFASP method for trace amounts of complex proteome samples. All these results demonstrate that the imFASP method developed here is of high potential for high efficient and high throughput preparation of trace amounts of complex proteome samples. PMID:26920773

  5. Organization into Higher Ordered Ring Structures Counteracts Membrane Binding of IM30, a Protein Associated with Inner Membranes in Chloroplasts and Cyanobacteria.

    PubMed

    Heidrich, Jennifer; Wulf, Verena; Hennig, Raoul; Saur, Michael; Markl, Jürgen; Sönnichsen, Carsten; Schneider, Dirk

    2016-07-15

    The IM30 (inner membrane-associated protein of 30 kDa), also known as the Vipp1 (vesicle-inducing protein in plastids 1), has a crucial role in thylakoid membrane biogenesis and maintenance. Recent results suggest that the protein binds peripherally to membranes containing negatively charged lipids. However, although IM30 monomers interact and assemble into large oligomeric ring complexes with different numbers of monomers, it is still an open question whether ring formation is crucial for membrane interaction. Here we show that binding of IM30 rings to negatively charged phosphatidylglycerol membrane surfaces results in a higher ordered membrane state, both in the head group and in the inner core region of the lipid bilayer. Furthermore, by using gold nanorods covered with phosphatidylglycerol layers and single particle spectroscopy, we show that not only IM30 rings but also lower oligomeric IM30 structures interact with membranes, although with higher affinity. Thus, ring formation is not crucial for, and even counteracts, membrane interaction of IM30. PMID:27226585

  6. Etudes physiques des mélanges eau-cryoprotecteurs

    NASA Astrophysics Data System (ADS)

    Vassoille, R.; Perez, J.

    The aim of the following review is to present the most important studies concerning the physical properties of water-solutes mixtures used in cryobiology. Cryobiology is a branch of biology which deals with the very low temperature behaviour of cells. This technique is developed today in several directions. The creation of banks of cells and perhaps in a short time of small organs, is the purpose of much research in this domain. Before freezing, living cells are generally put in a solution containing one or more solutes. The role of these solutes is to protect the cells against damage due to crystallization of water (cryoprotectors). The mechanisms of cryoprotection are not well known ; nevertheless the vitreous state formation during cooling is often invoked. So, it is possible to avoid crystallization damage such as mechanical strain (due to an increase of volume of about 10 %) and salt effects (due to osmotic pressure). The conditions in which the vitreous state is obtained, maintained during cooling, storage at low temperature and rewarming can be defined by physical studies presented in the following review. Le présent travail est essentiellement une revue bibliographique des principales études physiques qui ont été réalisées avec des solutions de composés habituellement employés en cryobiologie. La cryobiologie est une branche de la biologie qui s'intéresse au comportement des cellules à basse température. Cette discipline est actuellement en plein développement dans des domaines très divers. Son principal but est la création de banques de cellules de plus en plus complexes avec comme perspective la conservation des organes. Les cellules vivantes sont généralement placées avant congélation dans une solution contenant divers composés dont le rôle est de protéger les cellules contre les effets de la cristallisation de l'eau. L'action protectrice de ces cryoprotecteurs est encore mal connue; cependant, la formation d'un état vitreux lors du

  7. Superfund Record of Decision (EPA Region 7): Des Moines TCE Site, Operable Unit 3, Des Moines, IA. (Second remedial action), September 1992. Final report

    SciTech Connect

    Not Available

    1992-09-18

    The Des Moines TCE site is located southwest of downtown Des Moines, Polk County, Iowa. Land use in the area is predominantly industrial and commercial, and part of the site lies within the floodplain of the Raccoon River. Water from the Des Moines Water Works north infiltration gallery was found to be contaminated with trichloroethylene (TCE), dichloroethylene (DCE), and vinyl chloride at levels above accepted drinking water standards. The ROD addresses OU3, which encompasses potential sources of ground water contamination in an area north of the Raccoon River. The selected remedial action for OU3 includes no action with periodic groundwater monitoring.

  8. Caracterisation du coefficient de retrodiffusion radar des surfaces d'hydrocarbure: Modelisation et interpretation

    NASA Astrophysics Data System (ADS)

    Charbonneau, Francois

    La surveillance maritime est un domaine d'applications ou l'interet politique et scientifique croit constamment au Canada. Un des outils privilegies pour la surveillance maritime est l'acquisition de donnees radars, par des systemes aeroportes ou spatio-portes (ERS-2, RADARSAT et Envisat). Par leur grande couverture spatiale, ainsi que leur sensibilite a la geometrie de surface, les donnees radars permettent, en autres, la detection de cibles ponctuelles (bateaux), estimation des vents, detection des glaces de mer, ainsi que la detection de deversement d'hydrocarbure. Les limites et les avantages de la detection d'hydrocarbure par acquisitions de donnees radars sont bien connus, mais il reste encore des lacunes au niveau de l'extraction des parametres physiques d'une surface d'hydrocarbure. Ce projet a pour objectif de caracteriser le coefficient de retrodiffusion radar associe a une surface d'hydrocarbure en milieu oceanique, par l'introduction d'un modele thermodynamique d'attenuation de la surface, au modele theorique radar IEM. Le modele global permet de simuler le comportement de sigma° en fonction des proprietes visco-elastiques, ainsi que de l'epaisseur de la couche d'hydrocarbure et en fonction des parametres d'acquisition radar. Le modele developpe fut valide a partir des donnees SIR-C acquises lors d'experimentations controlees. A partir des informations environnementales et du type d'hydrocarbure, notre modele a permis d'estime le contraste d'intensite avec une precision de 1 a 1,5 dB, a la bande C. Alors qu'a la bande L, l'erreur sur le contraste est d'environ 1,5 a 2 dB sur l'ensemble des mesures. Ce qui est excellant considerant l'heterogeneite des surfaces analysees. Egalement, nous effectuons des analyses multi-polarisees et polarimetriques avec les donnees SIR-C acquises au-dessus de sites experimentaux. II en ressort que le ratio de polarisation VV/HH, ainsi que le facteur d'anisotropie sont des pistes de recherche prometteuses qu'il faudra

  9. Environnement des Systèmes Binaires Jeunes

    NASA Astrophysics Data System (ADS)

    Duchene, Gaspard

    2000-07-01

    La fréquence élevée des systèmes binaires, tant parmi les étoiles de la séquence principale que dans les régions de formation stellaire, a été largement mise en évidence au cours des dix dernières années. Cette constatation soulève naturellement la question de la nature du processus responsable de la formation préférentielle de ces systèmes multiples. Par ailleurs, les phénomènes d'interaction entre un compagnon et l'environnement complexe d'une étoile T Tauri sont encore trèsmal compris. C'est dans ce cadre que se place le travail conduit durant cette thèse, dont les principaux objectifs sont: i) la détermination de la fraction de binaires dans différentes populations pré-séquence principale, ii) l'étude quantitative du phénomène d'accrétion dans les systèmes binaires T Tauri, et iii) l'observation directe et la modélisation de disques circumstellaires et circumbinaires. Dans le cadre d'une recherche de binaires visuelles à l'aide du système d'optique adaptative du Télescope Canada-France-Hawaii, j'ai pris part à l'observation de plusieurs centaines d'objets situés dans différents amas stellaires jeunes. Je détaille ici l'analyse et les résultats concernant deux amas âgés de moins de deux millions d'années. Lorsqu'on considère l'ensemble des populations étudiées jusqu'à présent, on constate que la proportion de binaires visuelles parmi les étoiles de type solaire est la même dans les amas stellaires que sur la séquence principale. De plus, cette propriété ne dépend pas de l'âge de l'amas, ce qui implique que la fraction de binaires n'évolue pas après le premier million d'années dans ces amas. A l'opposé, les zones de formation peu denses, qui sont toutes très jeunes, possèdent une proportion de binaires sensiblement plus élevée. Les modèles les plus à même de reproduire ces observations sont ceux selon lesquels la fraction de binaires qui résulte de l'effondrement gravitationnel est proche de 100

  10. La prévention des blessures dans les terrains de jeux

    PubMed Central

    Fuselli, Pamela; Yanchar, Natalie L

    2012-01-01

    RÉSUMÉ Dans un climat d’inquiétude croissante à l’égard de l’obésité juvénile et de l’inactivité, les terrains de jeux permettent aux enfants d’être actifs. Ils comportent toutefois aussi des risques, les blessures causées par des chutes étant de loin les plus courants. Les recherches démontrent la possibilité de réduire les blessures dans les terrains de jeux si on abaisse la hauteur des structures de jeu et si on utilise des surfaces molles et profondes pour amortir les chutes. L’Association canadienne de normalisation a publié des normes volontaires qu’elle a mises à jour plusieurs fois pour tenir compte de ces risques. Afin de contribuer à les réduire, les parents peuvent respecter des stratégies simples. Le présent document de principes souligne le fardeau des blessures subies dans les terrains de jeux. Il procure également aux parents et aux dispensateurs de soins des occasions de réduire l’incidence et la gravité des blessures grâce à l’éducation et à la défense d’intérêts, ainsi que de mettre en œuvre des normes de sécurité probantes et des stratégies plus sécuritaires dans les terrains de jeux locaux. Enfin, il remplace le document de principes de la Société canadienne de pédiatrie publié en 2002 sur le sujet.

  11. Using IMS hydrophone data for detecting submarine volcanic activity: Insights from Monowai, 26°S Kermadec Arc

    NASA Astrophysics Data System (ADS)

    Metz, Dirk; Watts, Anthony B.; Grevemeyer, Ingo; Rodgers, Mel; Paulatto, Michele

    2016-04-01

    Only little is known on active volcanism in the ocean. As eruptions are attenuated by seawater and fallout does not regularly reach the sea surface, eruption rates and mechanisms are poorly understood. Estimations on the number of active volcanoes across the modern seas range from hundreds to thousands, but only very few active sites are known. Monowai is a submarine volcanic centre in the northern Kermadec Arc, Southwest Pacific Ocean. During May 2011, it erupted over a period of five days, with explosive activity directly linked to the generation of seismoacoustic tertiary waves ('T-phases'), recorded at three broadband seismic stations in the region. We show, using windowed cross-correlation and time-difference-of-arrival techniques, that T-phases associated with this eruption are detected as far as Ascension Island, South Atlantic Ocean, where two bottom-moored hydrophone arrays are operated as part of the International Monitoring System (IMS) of the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO). We observe a high incidence of T-phase arrivals during the time of the eruption, with the angle of arrival stabilizing at the geodesic azimuth between the IMS arrays and Monowai. T-phases from the volcanic centre must therefore have propagated through the Sound Fixing And Ranging (SOFAR) channel in the South Pacific and South Atlantic Oceans and over a total geodesic range of approximately 15,800 km, one of the longest source-receiver distances of any naturally occurring underwater signal ever observed. Our findings, which are consistent with observations at regional broadband stations and two dimensional, long-range, parabolic equation modelling, highlight the exceptional capabilities of the hydroacoustic waveform component of the IMS for remotely detecting episodes of submarine volcanic activity. Using Monowai and the hydrophone arrays at Ascension Island as a natural laboratory, we investigate the long-term eruptive record of a submarine volcano from

  12. Prehospital Use of IM Ketamine for Sedation of Violent and Agitated Patients

    PubMed Central

    Scheppke, Kenneth A.; Braghiroli, Joao; Shalaby, Mostafa; Chait, Robert

    2014-01-01

    Introduction Violent and agitated patients pose a serious challenge for emergency medical services (EMS) personnel. Rapid control of these patients is paramount to successful prehospital evaluation and also for the safety of both the patient and crew. Sedation is often required for these patients, but the ideal choice of medication is not clear. The objective is to demonstrate that ketamine, given as a single intramuscular injection for violent and agitated patients, including those with suspected excited delirium syndrome (ExDS), is both safe and effective during the prehospital phase of care, and allows for the rapid sedation and control of this difficult patient population. Methods We reviewed paramedic run sheets from five different catchment areas in suburban Florida communities. We identified 52 patients as having been given intramuscular ketamine 4mg/kg IM, following a specific protocol devised by the EMS medical director of these jurisdictions, to treat agitated and violent patients, including a subset of which would be expected to suffer from ExDS. Twenty-six of 52 patients were also given parenteral midazolam after medical control was obtained to prevent emergence reactions associated with ketamine. Results Review of records demonstrated that almost all patients (50/52) were rapidly sedated and in all but three patients no negative side effects were noted during the prehospital care. All patients were subsequently transported to the hospital before ketamine effects wore off. Conclusion Ketamine may be safely and effectively used by trained paramedics following a specific protocol. The drug provides excellent efficacy and few clinically significant side effects in the prehospital phase of care, making it an attractive choice in those situations requiring rapid and safe sedation especially without intravenous access. PMID:25493111

  13. Thermal Effects on the Compressive Behavior of IM7/PET15 Laminates

    NASA Technical Reports Server (NTRS)

    Walker, Sandra Polesky

    2003-01-01

    The effect of changing operating temperature on the compressive response of IM7/PETI5 composite laminates is investigated within this paper. The three temperatures evaluated for this study were 129 C, 21 C, and 177 C, a spectrum from cryogenic to an elevated operating temperature. Laminate compressive strength property testing was conducted using the Wyoming Combined Load Compression fixture to generate strength data at the three operating temperatures of interest for several lay-ups. A three-dimensional finite element analysis model of a [90/0]8s composite laminate subject to compressive loading is developed. The model is used to study the key attributes of the laminate that significantly influence the state of stress in the laminate. Both the resin rich layer located between lamina and the thermal residual stresses present in the laminate due to curing are included in the analysis model. For the laminate modeled, the effect of modeling temperature dependent material properties was determined to be insignificant for the operating temperatures studied. Simply using the material properties measured at the operating temperature of interest was sufficient for predicting stresses accurately in a linear analysis for the current problem. The three-dimensional analysis results revealed that the application of an applied compressive axial load in the 0-degree direction decreased the interlaminar stresses present in the laminate initially due to curing. Therefore, failure was concluded not be attributable to the interlaminar stresses in the composite laminate being studied when a compressive load is applied. The magnitude of the measured laminate compressive strength change with a change in temperature is concluded to be dominated by the change in the lamina compressive axial strength with a change in temperature.

  14. SN 2012im/2013ek: A Supernova Double Take in NGC 6984

    NASA Astrophysics Data System (ADS)

    Milisavljevic, Dan

    2013-10-01

    An unprecedented transient event has just been detected in a spiral arm of NGC 6984. Two H-poor supernovae - SN 2012im and 2013ek - both originating from massive stripped-envelope progenitor stars have been found at virtually the same location {< 0.4 arcsec}. Interpretations have varied widely. Chance alignment of two completely independent supernovae of the same Type Ib/c class exploding within one year of each other from the same stellar cluster is statistically improbable. Thus, the two explosions are most likely physically related, and this has important ramifications in areas of high-mass binary star evolution and explosion mechanisms of core-collapse supernovae.High resolution HST images are the only means by which to probe the stellar environment of the progenitor system. To this end, we request WFC3/UVIS imaging in F336W, F475W, F555W, and F814W of SN 2013ek in the next month while SN 2013ek is still bright to pin down its precise location within a nearby cluster of stars visible in an archival plate of NGC 6984. Complementary follow-up images will be requested during regular GO proposals in Cycle 22 when the fading supernova reveals what is left behind. The proposed suite of images will allow us to model the cluster's broadband colors to determine properties of the progenitor star system's environment {e.g., mass, age, luminosity, star formation rate, metallicity} that will be used to constrain possible explosion scenarios.We request Director's Discretionary time for these observations as a non-disruptive TOO.

  15. "Complex" Posttraumatic Stress Disorder/Disorders of Extreme Stress (CP/DES) in Sexually Abused Children: An Exloratory Study.

    ERIC Educational Resources Information Center

    Hall, Darlene Kordich

    1999-01-01

    Compares three groups of young sexually abused children on seven "Complex" Posttraumatic Stress Disorder/Disorders of Extreme Stress (CP/DES) indices. As cumulative number of types of trauma increased, the number of CP/DES symptoms rose. Results suggest that CP/DES also characterizes sexually abused children, especially those who have been…

  16. The Des Moines Plan: A Plan for Student Success, 1987-88. Report of Evaluation.

    ERIC Educational Resources Information Center

    Schnelker, Diane; Tompkins, John

    The comprehensive Des Moines Plan (DMP) for Des Moines, Iowa elementary through high school students throughout the district who require academic support was evaluated, as implemented during 1987-88. The plan represents an expansion and reorganization of all district remedial programs, and receives federal, state, and local funding. The DMP…

  17. Le contrôle des infections au cabinet du pédiatre

    PubMed Central

    2008-01-01

    RÉSUMÉ La transmission des infections au cabinet du pédiatre est de plus en plus préoccupante. Le présent document expose les voies de transmission des infections et les principes sous-jacents aux mesures actuelles pour contrôler les infections. Pour prévenir les infections, il faut bien concevoir le cabinet et adopter des politiques administratives et de triage convenables, de même que des pratiques de base pour les soins de tous les patients (p. ex., hygiène des mains, port de gants, de masques, de lunettes de protection et d’une blouse d’hôpital pour des interventions précises; nettoyage, désinfection et stérilisation convenables des surfaces et du matériel, y compris les jouets, et techniques d’asepsie en cas d’interventions effractives) et des précautions additionnelles en cas d’infections précises. Le personnel doit avoir reçu les vaccins pertinents, et les personnes infectées doivent respecter les politiques de restriction au travail.

  18. Plasma IMS Composition Measurements for Europa and the Other Galilean Moons

    NASA Astrophysics Data System (ADS)

    Sittler, Edward; Cooper, John; Hartle, Richard; Lipatov, Alexander; Mahaffy, Paul; Paterson, William; Pachalidis, Nick; Coplan, Mike; Cassidy, Tim

    2010-05-01

    NASA and ESA are planning the joint Europa Jupiter System Mission (EJSM) to the Jupiter system with specific emphasis to Europa and Ganymede, respectively. The Japanese Space Agency is also planning an orbiter mission to explore Jupiter's magnetosphere and the Galilean satellites. For NASA's Jupiter Europa Orbiter (JEO) we are developing the 3D Ion Mass Spectrometer (IMS) with two main goals which can also be applied to the other Galilean moons, 1) measure the plasma interaction between Europa and Jupiter's magnetosphere and 2) infer the 4? surface composition to trace elemental [1] and significant isotopic levels. The first goal supports the magnetometer (MAG) measurements, primarily directed at detection of Europa's sub-surface ocean, while the second gives information about transfer of material between the Galilean moons, and between the moon surfaces and subsurface layers putatively including oceans. The measurement of the interactions for all the Galilean moons can be used to trace the in situ ion measurements of pickup ions back to either Europa's or Ganymede's surface from the respectively orbiting spacecraft. The IMS instrument, being developed under NASA's Astrobiology Instrument Development Program, would maximally achieve plasma measurement requirements for JEO and EJSM while moving forward our knowledge of Jupiter system composition and source processes to far higher levels than previously envisaged. The composition of the global surfaces of Europa and Ganymede can be inferred from the measurement of ejected neutrals and pick-up ions using at minimum an in situ payload including MAG and IMS also fully capable of meeting Level 1 mission requirements for ocean detection and survey. Elemental and isotopic analysis of potentially extruded oceanic materials at the moon surfaces would further support the ocean objectives. These measurements should be made from a polar orbiting spacecraft about Europa or Ganymede at height ~ 100 km. The ejecta produced by

  19. Lignes directrices canadiennes sur l’utilisation sécuritaire et efficace des opioïdes pour la douleur chronique non cancéreuse

    PubMed Central

    Kahan, Meldon; Mailis-Gagnon, Angela; Wilson, Lynn; Srivastava, Anita

    2011-01-01

    Résumé Objectif Présenter aux médecins de famille un résumé clinique pratique des lignes directrices canadiennes sur l’utilisation sécuritaire et efficace des opioïdes pour la douleur chronique non cancéreuse, produites par le National Opioid Use Guideline Group. Qualité des données Pour produire les lignes directrices, les chercheurs ont effectué une synthèse critique de la littérature médicale sur l’efficacité et l’innocuité des opioïdes pour la douleur chronique non cancéreuse et ont rédigé une série de recommandations. Un panel de 49 cliniciens experts de toutes les régions du Canada ont passé en revue l’ébauche et ont atteint un consensus sur 24 recommandations. Message principal Il est recommandé de faire un dépistage du risque de dépendance avant de prescrire des opioïdes. On recommande des opioïdes faibles (codéine et tramadol) pour une douleur de légère à modérée qui n’a pas répondu aux traitements de première intention. On peut essayer l’oxycodone, l’hydromorphone et la morphine chez les patients qui n’ont pas eu de soulagement avec des opioïdes plus faibles. Une faible dose initiale et une lente hausse du titrage sont recommandées, ainsi qu’une étroite surveillance du patient qu’on a d’abord renseigné. Les médecins doivent surveiller l’apparition de complications comme l’apnée du sommeil. La dose optimale est celle qui améliore le fonctionnement ou atténue les cotes d’évaluation de la douleur d’au moins 30 %. Pour la grande majorité des patients, la dose optimale sera bien en deçà de l’équivalent de 200 mg de morphine par jour. On recommande le sevrage progressif pour les patients qui n’ont pas répondu à un essai d’opioïdes adéquat. Conclusion Les opioïdes jouent un rôle important dans la prise en charge de la douleur chronique non cancéreuse, mais il faut en prescrire avec prudence pour limiter les dommages potentiels. Les nouvelles lignes directrices

  20. Comprendre la maltraitance des aînés en pratique familiale

    PubMed Central

    Yaffe, Mark J.; Tazkarji, Bachir

    2012-01-01

    Résumé Objectif Présenter ce qui constitue la maltraitance des aînés, ce dont les médecins de famille devraient être au courant, les signes et les symptômes laissant présager de mauvais traitements chez des adultes plus âgés, comment l’outil Elder Abuse Suspicion Index peut aider à détecter la maltraitance et les options qui existent pour réagir en cas de soupçons de maltraitance. Sources des données On a fait une recension dans MEDLINE, PsycINFO et Social Work Abstracts pour trouver des publications en français ou en anglais, de 1970 à 2011, à l’aide des expressions elder abuse, elder neglect, elder mistreatment, seniors, older adults, violence, identification, detection tools et signs and symptoms. Les publications pertinentes ont fait l’objet d’un examen. Message principal La maltraitance des aînés est une cause importante de morbidité et de mortalité chez les adultes plus âgés. Si les médecins de famille sont bien placés pour détecter des mauvais traitements infligés aux aînés, leurs taux réels de signalement de cas de maltraitance sont plus faibles que dans d’autres professions. Cette situation pourrait s’améliorer s’ils comprenaient mieux les genres d’agissements qui constituent de la maltraitance des aînés, ainsi que les signes et les symptômes observés au bureau qui pourraient pointer vers des cas de mauvais traitements. La détection de tels cas pourrait être facilitée par le recours à un court outil validé, comme l’Elder Abuse Suspicion Index. Conclusion Les médecins de famille peuvent jouer un rôle plus important dans la détection d’une éventuelle maltraitance des aînés. Une fois qu’on soupçonne de mauvais traitements, il existe dans la plupart des communautés des services sociaux ou des forces de l’ordre accessibles pour effectuer des évaluations plus approfondies et intervenir.

  1. What We Did Last Summer: Depicting DES Data to Enhance Simulation Utility and Use

    NASA Technical Reports Server (NTRS)

    Elfrey, Priscilla; Conroy, Mike; Lagares, Jose G.; Mann, David; Fahmi, Mona

    2009-01-01

    At Kennedy Space Center (KSC), an important use of Discrete Event Simulation (DES) addresses ground operations .of missions to space. DES allows managers, scientists and engineers to assess the number of missions KSC can complete on a given schedule within different facilities, the effects of various configurations of resources and detect possible problems or unwanted situations. For fifteen years, DES has supported KSC efficiency, cost savings and improved safety and performance. The dense and abstract DES data, however, proves difficult to comprehend and, NASA managers realized, is subject to misinterpretation, misunderstanding and even, misuse. In summer 2008, KSC developed and implemented a NASA Exploration Systems Mission Directorate (ESMD) project based on the premise that visualization could enhance NASA's understanding and use of DES.

  2. La prévention des infections par le virus respiratoire syncytial

    PubMed Central

    Robinson, JL

    2011-01-01

    RÉSUMÉ L’infection par le virus respiratoire syncytial (VRS) est la principale cause d’infections des voies respiratoires inférieures chez les jeunes enfants. Le palivizumab, un anticorps monoclonal anti-VRS, réduit le taux d’hospitalisation des enfants à haut risque mais est très coûteux. Le présent document de principes remplace les trois précédents documents de principes de la Société canadienne de pédiatrie sur le sujet et est mis à jour principalement pour traiter des récentes modifications aux lignes directrices de l’American Academy of Pediatrics dans le contexte canadien. Il contient une analyse des publications ainsi que des recommandations au sujet de l’utilisation du palivizumab chez les enfants à haut risque

  3. Approche à l’égard des nouveaux anticoagulants oraux en pratique familiale

    PubMed Central

    Douketis, James; Bell, Alan David; Eikelboom, John; Liew, Aaron

    2014-01-01

    Résumé Objectif Comparer les caractéristiques principales des nouveaux anticoagulants oraux (NACO), soit le dabigatran, le rivaroxaban et l’apixaban, et répondre aux questions qui font surface lors de la comparaison de ces agents. Qualité des données Une recherche dans PubMed a été effectuée afin de relever les études cliniques récentes (de janvier 2008 à la semaine 32 de 2013) portant sur l’emploi des NACO pour la prévention des AVC dans les cas de fibrillation auriculaire (FA) et pour le traitement de la thromboembolie veineuse aiguë. Message principal Selon 3 essais d’envergure, tous les NACO sont au moins aussi efficaces que la warfarine dans la prévention des AVC chez les patients atteints d’une FA non valvulaire, et au moins aussi sûrs pour ce qui est du risque de saignement. Des méta-analyses de ces essais ont montré que, comparativement au traitement par la warfarine, les NACO avaient réduit la mortalité totale, la mortalité d’origine cardiovasculaire et les saignements intracrâniens, et était aussi ressortie une tendance vers la réduction des saignements généraux. Du côté pratique, les avantages des NACO par rapport à la warfarine sont : posologie orale fixe uniquotidienne ou biquotidienne sans devoir surveiller la coagulation et peu d’interactions connues ou définies avec d’autres médicaments ou des aliments. Les désavantages potentiels des NACO sont notamment un risque de saignement qui serait accru chez les patients de plus de 75 ans, une hausse des saignements gastro-intestinaux majeurs avec des doses élevées de dabigatran, une hausse des cas de dyspepsie avec le dabigatran, l’absence d’un test de laboratoire de routine visant à mesurer de façon fiable l’effet anticoagulant et l’absence d’antidote pour renverser l’effet anticoagulant. Aucun essai randomisé contrôlé n’a effectué de comparaison directe des NACO, et le choix d’un NACO est influencé par les caract

  4. Prévalence des cervicalgies et douleurs des membres supérieures chez les utilisateurs d'ordinateur en milieu professionnel à Casablanca (Maroc)

    PubMed Central

    Seknaji, Nawal; Rachidi, Wafaa; Hassoune, Samira; Janani, Saadia; Nani, Samira; Maaroufi, Abderrahmane; Mkinsi, Ouafaa

    2013-01-01

    Introduction Les cervicalgies et douleurs du membre supérieur (CDMS) affectent des millions d'utilisateurs d'ordinateurs dans les pays développés. L'objectif de ce travail était de déterminer la prévalence des cervicalgies et douleurs du membre supérieur (CDMS) à Casablanca et identifier les différents facteurs de risque qui y sont impliqués, afin de définir les sous-groupes à haut risque, et d’établir des plans d'intervention efficaces. Méthodes Il s'agit d'une étude transversale, menée chez 118 employés de bureau francophones et utilisant l'ordinateur, à Casablanca. Les données ont été collectées de Décembre 2011 à Juin 2012, en utilisant la version française d'un questionnaire validé: Maastricht-Upper-extremity-Questionnaire. Résultats 118 utilisateurs d'ordinateur en milieu professionnel ont été recrutés. Parmi les employés enquêtés, 93% ont rapporté des CDMS localisées au moins à un site. Les plaintes les plus fréquemment rapportées étaient les douleurs des épaules et les cervicalgies (48,3% et 46,6% respectivement). Nous n'avons pas remarqué de différence significative des fréquences des douleurs selon le genre. Nos résultats concordent avec les données de la littérature où il existe un certain consensus quant à l'impact des mauvaises conditions ergonomiques sur les troubles musculo-squelettiques du membre supérieur en milieu professionnel. De même, les études récentes examinant les effets combinés et/ou interactifs tant des facteurs biomécaniques/physiques que de facteurs psychosociaux professionnels vont de pair avec nos résultats. Conclusion Il en ressort que les stratégies d'intervention visant à réduire les CDMS doivent agir essentiellement sur 3 volets, le premier correspond à l'amélioration et la sensibilisation quant au respect des conditions ergonomiques, le second concerne l'amélioration des conditions psychosociales. Enfin le troisième volet vise la rationalisant de la demande de

  5. Cosmology from Cosmic Shear with DES Science Verification Data

    SciTech Connect

    Abbott, T.

    2015-07-20

    We present the first constraints on cosmology from the Dark Energy Survey (DES), using weak lensing measurements from the preliminary Science Verification (SV) data. We use 139 square degrees of SV data, which is less than 3% of the full DES survey area. Using cosmic shear 2-point measurements over three redshift bins we find σ8(m=0.3)0.5 = 0:81 ± 0:06 (68% confidence), after marginalising over 7 systematics parameters and 3 other cosmological parameters. Furthermore, we examine the robustness of our results to the choice of data vector and systematics assumed, and find them to be stable. About 20% of our error bar comes from marginalising over shear and photometric redshift calibration uncertainties. The current state-of-the-art cosmic shear measurements from CFHTLenS are mildly discrepant with the cosmological constraints from Planck CMB data. Our results are consistent with both datasets. Our uncertainties are ~30% larger than those from CFHTLenS when we carry out a comparable analysis of the two datasets, which we attribute largely to the lower number density of our shear catalogue. We investigate constraints on dark energy and find that, with this small fraction of the full survey, the DES SV constraints make negligible impact on the Planck constraints. The moderate disagreement between the CFHTLenS and Planck values of σ8m=0.3)0.5 is present regardless of the value of w.

  6. DES exposure checker: Dark Energy Survey image quality control crowdsourcer

    NASA Astrophysics Data System (ADS)

    Melchior, Peter; Sheldon, Erin; Drlica-Wagner, Alex; Rykoff, Eli S.

    2015-11-01

    DES exposure checker renders science-grade images directly to a web browser and allows users to mark problematic features from a set of predefined classes, thus allowing image quality control for the Dark Energy Survey to be crowdsourced through its web application. Users can also generate custom labels to help identify previously unknown problem classes; generated reports are fed back to hardware and software experts to help mitigate and eliminate recognized issues. These problem reports allow rapid correction of artifacts that otherwise may be too subtle or infrequent to be recognized.

  7. LANDSAT-4 image data quality analysis. [Des Moines, Iowa area

    NASA Technical Reports Server (NTRS)

    Anuta, P. E.

    1983-01-01

    Seven heterogeneous areas within the Des Moines, Iowa area test site were selected to define candidate spectral training classes using a clustering algorithm. In addition to the 91 cluster (nonsupervised) classes, three supervised training classes were defined and subsequently included in the training statistics file. The identity of all 94 candidate classes were determined using available reference data. Through analysis of the interclass separabilities, the original 94 candidate training classes were reduced to 42 spectrally separable final classes. The minimum average transformed divergence values for the 42 spectral classes and for the best subsets of TM spectral bands are shown in a table.

  8. Prise en charge des traumatismes graves du rein

    PubMed Central

    Lakmichi, Mohamed Amine; Jarir, Redouane; Sadiki, Bader; Zehraoui; Bentani; Wakrim, Bader; Dahami, Zakaria; Moudouni; Sarf, Ismail

    2015-01-01

    Les traumatismes graves du rein de grade III, IV et V selon la classification de l'Amercan Society for Surgery For Trauma (ASST) sont plus rares et se retrouvent dans 5% des cas en moyenne. Leur prise en charge est souvent délicate, nécessitant alors des centres expérimentés dotés de moyen adéquats d'imagerie (scanner spiralé). Cependant, durant ces dernières années, la prise en charge de ces traumatismes a évolué vers une attitude de moins en moins chirurgicale grâce à l’évolution des techniques de la radiologie interventionnelle, de l'endourologie et des moyens de surveillance aux urgences et de réanimation. L'objectif de cette étude est d’évaluer notre expérience dans la prise en charge des traumatismes rénaux de haut grade. Notre étude rétrospective porte sur 25 cas de traumatismes grave du rein de grade III, IV et V selon la classification de l'ASST, colligés entre Janvier 2002 et Juin 2009 au service d'urologie du centre Hospitalier Universitaire Mohammed VI, Université Cadi Ayyad de Marrakech, Maroc. Nous avons étudié les données épidémiologiques, les signes cliniques et biologiques à l'admission (état de choc hémorragique, taux d'hémoglobine), les données radiologiques (échographie et scanner), les lésions associées, la prise en charge thérapeutique et les complications. L’âge moyen de nos patients était de 24,9 ans 15 et 58 ans, avec une prédominance masculine (sex-ratio = 7, 3). Le rein droit était intéressé dans 15 cas (60%). Le traumatisme rénal était fermé dans 15 cas, et ouvert par arme blanche dans 10 cas. Huit patients se sont présentés en état de choc hémorragique (32%). Une anémie inférieur à 10g /100ml a été observée dans 10 cas (40%). L'uroscanner fait systématiquement à l'admission a retrouvé un grade III (10 cas), grade IV (13 cas) et grade V (2 cas). La prise en charge a consisté en une exploration chirurgicale avec néphrectomie chez 2 cas de Grade IV pour une instabilité h

  9. Le syndrome des brides amniotiques et ses difficultés diagnostiques et de prise en charge au Burkina Faso

    PubMed Central

    Nagalo, Kisito; Badiel, Roger; Kouéta, Fla; Tall, François Housséini; Yé, Diarra

    2015-01-01

    Le syndrome des brides amniotiques est une embryo-foetopathie rare, d’étiopathogénie encore inconnue, caractérisé par des malformations crânio-faciales, thoraco-abdominales, des membres et des extrémités. Afin de discuter des difficultés diagnostiques et thérapeutiques du syndrome des brides amniotiques, nous rapportons cinq cas de ce syndrome. Ces cas représentaient autant de phénotypes de la maladie mais avec quelques singularités. Les deux premiers étaient des cas de maladie des brides amniotiques caractérisés l'un par une amputation d'un membre inférieur associée à des lésions cutanées et à une surdité, l'autre par des strictions avec amputation des doigts associées à une fente labio-palatine, une cataracte congénitale et un strabisme. Les trois autres cas correspondaient à des formes létales du Limb Body Wall Complex dont deux avec attache placento-crânienne et un avec attache placento-abdominale. Le renforcement du diagnostic anténatal, l'instauration du conseil génétique et la mise en place d'un registre national des malformations devraient permettre d'améliorer la prise en charge des cas du syndrome des brides amniotiques. PMID:26113939

  10. Integration des sciences et de la langue: Creation et experimentation d'un modele pedagogique pour ameliorer l'apprentissage des sciences en milieu francophone minoritaire

    NASA Astrophysics Data System (ADS)

    Cormier, Marianne

    Les faibles resultats en sciences des eleves du milieu francophone minoritaire, lors d'epreuves au plan national et international, ont interpelle la recherche de solutions. Cette these avait pour but de creer et d'experimenter un modele pedagogique pour l'enseignement des sciences en milieu linguistique minoritaire. En raison de la presence de divers degres de francite chez la clientele scolaire de ce milieu, plusieurs elements langagiers (l'ecriture, la discussion et la lecture) ont ete integres a l'apprentissage scientifique. Nous avions recommande de commencer le processus d'apprentissage avec des elements langagiers plutot informels (redaction dans un journal, discussions en dyades...) pour progresser vers des activites langagieres plus formelles (redaction de rapports ou d'explications scientifiques). En ce qui a trait a l'apprentissage scientifique, le modele preconisait une demarche d'evolution conceptuelle d'inspiration socio-constructiviste tout en s'appuyant fortement sur l'apprentissage experientiel. Lors de l'experimentation du modele, nous voulions savoir si celui-ci provoquait une evolution conceptuelle chez les eleves, et si, simultanement, le vocabulaire scientifique de ces derniers s'enrichissait. Par ailleurs, nous cherchions a comprendre comment les eleves vivaient leurs apprentissages dans le cadre de ce modele pedagogique. Une classe de cinquieme annee de l'ecole de Grande-Digue, dans le Sud-est du Nouveau-Brunswick, a participe a la mise a l'essai du modele en etudiant les marais sales locaux. Lors d'entrevues initiales, nous avons remarque que les connaissances des eleves au sujet des marais sales etaient limitees. En effet, s'ils etaient conscients que les marais etaient des lieux naturels, ils ne pouvaient pas necessairement les decrire avec precision. Nous avons egalement constate que les eleves utilisaient surtout des mots communs (plantes, oiseaux, insectes) pour decrire le marais. Les resultats obtenus indiquent que les eleves ont

  11. Stable and unstable accretion in the classical T Tauri stars IM Lup and RU Lup as observed by MOST

    NASA Astrophysics Data System (ADS)

    Siwak, Michal; Ogloza, Waldemar; Rucinski, Slavek M.; Moffat, Anthony F. J.; Matthews, Jaymie M.; Cameron, Chris; Guenther, David B.; Kuschnig, Rainer; Rowe, Jason F.; Sasselov, Dimitar; Weiss, Werner W.

    2016-03-01

    Results of the time variability monitoring of the two classical T Tauri stars, RU Lup and IM Lup, are presented. Three photometric data sets were utilized: (1) simultaneous (same field) MOST satellite observations over four weeks in each of the years 2012 and 2013, (2) multicolour observations at the South African Astronomical Observatory in April-May of 2013, (3) archival V-filter All Sky Automated Survey (ASAS) data for nine seasons, 2001-2009. They were augmented by an analysis of high-resolution, public-domain VLT-UT2 Ultraviolet Visual Echelle Spectrograph spectra from the years 2000 to 2012. From the MOST observations, we infer that irregular light variations of RU Lup are caused by stochastic variability of hotspots induced by unstable accretion. In contrast, the MOST light curves of IM Lup are fairly regular and modulated with a period of about 7.19-7.58 d, which is in accord with ASAS observations showing a well-defined 7.247 ± 0.026 d periodicity. We propose that this is the rotational period of IM Lup and is due to the changing visibility of two antipodal hotspots created near the stellar magnetic poles during the stable process of accretion. Re-analysis of RU Lup high-resolution spectra with the broadening function approach reveals signs of a large polar coldspot, which is fairly stable over 13 years. As the star rotates, the spot-induced depression of intensity in the broadening function profiles changes cyclically with period 3.710 58 d, which was previously found by the spectral cross-correlation method.

  12. Physik des erdnahen Weltraums. Eine Einführung

    NASA Astrophysics Data System (ADS)

    Pröss, Gerd W.

    Dieses Buch, das in die Gebiete, Methoden und Ergebnisse der Extraterrestrischen Physik einführen möchte, wendet sich an ein relativ breites Publikum. Vorausgesetzt werden lediglich Grundkenntnisse der Mathematik und Physik, wie sie in den ersten Semestern eines natur- oder ingenieurwissenschaftlichen Studiums erworben werden. Spezielleres Wissen wird im Zusammenhang mit dem jeweils betrachteten Phänomen abgeleitet. Es eignet sich daher sowohl zum Selbststudium für Quereinsteiger als auch vorlesungsbegleitend für alle Studenten der Fachrichtungen Physik, Geophysik, Meteorologie und Astronomie. Contents: 1. Einleitung. 2. Neutrale Hochatmosphäre. 3. Absorption und Dissipation von Sonnenstrahlungsenergie. 4. Ionosphäre. 5. Magnetosphäre. 6. Interplanetares Medium. 7. Absorption und Dissipation von Sonnenwindenergie. 8. Geosphärenstürme.

  13. Angular Velocity's Neural Network Observer of the Electric Drive of TVR - IM Type Implemented in Software Environment LabVIEW

    NASA Astrophysics Data System (ADS)

    Kozlova, L.; Bolovin, E.; Payuk, L.

    2016-06-01

    One of the common ways to manage a smooth starting and stopping of asynchronous motors are soft-start system. For this provision is necessary to use a closed speed asynchronous electric drive of tiristor voltage regulator - induction motor (TVR-IM) type. Using real sensors significantly increases the cost of installation and also introduces a number of inconveniences in the operation of the actuator. Observer has clear advantages that are created on artificial neural network. Creating a neural network observer in program graphic programming LabVIEW will allow to evaluate the speed of rotation of the asynchronous electric.

  14. The Semi-opened Infrastructure Model (SopIM): A Frame to Set Up an Organizational Learning Process

    NASA Astrophysics Data System (ADS)

    Grundstein, Michel

    In this paper, we introduce the "Semi-opened Infrastructure Model (SopIM)" implemented to deploy Artificial Intelligence and Knowledge-based Systems within a large industrial company. This model illustrates what could be two of the operating elements of the Model for General Knowledge Management within the Enterprise (MGKME) that are essential to set up the organizational learning process that leads people to appropriate and use concepts, methods and tools of an innovative technology: the "Ad hoc Infrastructures" element, and the "Organizational Learning Processes" element.

  15. Brief Communication: 2014 velocity and flux for five major Greenland outlet glaciers using ImGRAFT and Landsat-8

    NASA Astrophysics Data System (ADS)

    Messerli, A.; Karlsson, N. B.; Grinsted, A.

    2014-12-01

    This study presents average velocity fields, mass flux estimates and central flowline profiles for five major Greenland outlet glaciers; Jakobshavn Isbræ, Nioghalvfjerdsbræ, Kangerdlugssuaq, Helheim and Petermann glaciers, spanning the period (August) 2013-(September) 2014. The results are produced by the feature tracking toolbox, ImGRAFT using Landsat-8, panchromatic data. The resulting velocity fields agree with the findings of existing studies. Furthermore, our results show an unprecedented speed of over 50 m day-1 at Jakobshavn Isbræ as it continues to retreat. All the processed data will be freely available for download at http://imgraft.glaciology.net.

  16. Could the IMS Infrasound Stations Support a Global Network of Small Aperture Seismic Arrays?

    NASA Astrophysics Data System (ADS)

    J, Gibbons, Steven; Kværna, Tormod; Mykkeltveit, Svein

    2015-04-01

    The infrasound stations of the International Monitoring System are arrays consisting of up to 15 sites and with apertures of up to 3 km. The arrays are distributed remarkably uniformly over the globe and provide excellent coverage of South America, Africa, and Antarctica. This is to say that there are many infrasound arrays in regions many thousands of kilometers from the closest seismic array. Several infrasound arrays are in the immediate vicinity of existing 3-component seismic stations and these provide us with examples of how typical seismic signals look at these locations. We can make idealized estimates of the predicted performance of seismic arrays, consisting of seismometers at each site of the infrasound arrays, by duplicating the signals from the 3-C stations at all sites of the array. However, the true performance of seismic arrays at these sites will depend both upon Signal-to-Noise Ratios of seismic signals and the coherence of both signal and noise between sensors. These properties can only be determined experimentally. Recording seismic data of sufficient quality at many of these arrays may require borehole deployments since the microbarometers in the infrasound arrays are often situated in vaults placed in soft sediments. The geometries of all the current IMS infrasound arrays are examined and compared and we demonstrate that, from a purely geometrical perspective, essentially all the array configurations would provide seismic arrays with acceptable slowness resolution for both regional and teleseismic phase arrivals. Seismic arrays co-located with the infrasound arrays in many regions would likely enhance significantly the seismic monitoring capability in parts of the world where only 3-component stations are currently available. Co-locating seismic and infrasound sensors would facilitate the development of seismic arrays that share the infrastructure of the infrasound arrays, reducing the development and operational costs. Hosting countries might

  17. Re-establishment of the IMS Hydroacoustic Station HA03, Robinson Crusoe Island, Chile

    NASA Astrophysics Data System (ADS)

    Haralabus, Georgios; Stanley, Jerry; Zampolli, Mario; Pautet, Lucie

    2015-04-01

    Water column hydrophone stations of the Comprehensive Nuclear-Test-Ban Treaty Organisation (CTBTO) International Monitoring System (IMS) comprise typically two triplets of moored hydrophones deployed on both sides of an island. Triplet distances vary approximately between 50 - 200 km from the island, with each triplet connected to the receiving shore equipment by fibre-optic submarine data cables. Once deployed, the systems relay underwater acoustic waveforms in the band 1 - 100 Hz in real time to Vienna via a shore based satellite link. The design life of hydroacoustic (HA) stations is at least 20 years, without need for any maintenance of the underwater system (UWS). The re-establishment of hydrophone station HA03 at Robinson Crusoe Island (670 km West of the Chilean mainland) is presented here. The station was destroyed in February 2010 by a Tsunami induced by an 8.8 magnitude earthquake. After a major engineering and logistical undertaking HA03 is now back in operation since April 2014. The main phases of the project are presented: (i) the installation of a shore facility for the reception of the hydrophone data from the UWS, which also relays the data back to the CTBTO International Data Center (IDC) in Vienna via a real-time satellite connection, (ii) the manufacturing and testing of the system to meet the stringent requirements of the Nuclear-Test-Ban Treaty, and (iii) the installation of the UWS with a state-of-the-art cable ship. Examples of data acquired by HA03 are also presented. These include hydroacoustic signals from the 1 April 2014 magnitude 8.2 earthquake in Northern Chile, bursting underwater bubbles from a submarine volcano near the Mariana Islands (15,000 Km away from the station), and vocalizations from the numerous marine mammals which transit in the vicinity of HA03. The use of CTBTO data for scientific purposes is possible via the virtual Data Exploitation Centre (vDEC), which is a platform that enables registered researchers to access

  18. Résultats du traitement du synovialosarcome des members

    PubMed Central

    Lukulunga, Loubet Unyendje; Moussa, Abdou Kadri; Mahfoud, Mustapha; El Bardouni, Ahmed; Ismail, Farid; Kharmaz, Mohammed; Berrada, Mohamed Saleh; El Yaacoubi, Moradh

    2014-01-01

    Les synovialosarcomes, sarcomes de haut grade, sont de diagnostic tardif et le traitement est complexe et onéreux, nécessitant la mise en œuvre d'une équipe pluridisciplinaire. Le but de ce travail était d'apprécier les résultats de l'association de la chirurgie à la radio chimiothérapie des synovialosarcomes des membres. Il s'agissait d'une étude rétrospective portant sur des patients présentant de synovialosarcomes des membres pris en charge dans le service de chirurgie orthopédique et traumatologique du CHU Ibn SINA de Rabat allant de Janvier 2006 à Décembre 2011 (6 ans). Nous avons inclus les malades présentant de synovialosarcomes des membres dont la clinique et l'imagerie médicale étaient en faveur, confirmés par l'examen anatomopathologique et la prise en charge effectuée dans le service. Les patients ont été revus avec un recul moyen de 3 ans. Nous n'avons pas retenu les patients dont les dossiers étaient incomplets, perdus de vue. Nous avons apprécié les résultats selon les critères carcinologiques et le score MSTS (Musculoskeletal Tumor Society). La saisie et l'analyse des données ont été faites sur le logiciel SPSS Stastic 17.0 Nous avons colligé 20 cas de synovialosarcome des membres dans le Service de Chirurgie Orthopédique et Traumatologique au CHU Ibn SINA de Rabat Le sexe masculin a prédominé avec 65% (n = 13) avec un sex ratio 1,85. L’âge moyen a été de 42,6 ans avec des extrêmes allant de 20 ans et 70 ans. Notre délai moyen de consultation était de 14,42 mois. Tous les malades ont consulté pour une tuméfaction dans 100% (localisée au membre inférieur dans 65% (n = 13), membre supérieur dans 35% (n = 7). La douleur était associée à la tuméfaction dans 55% (n = 11), quant à l'altération de l’état général et l'ulcération de la masse, elles ont été notées dans 3 cas chacune. Nous avons réalisé un bilan d'imagerie médicale comprenant: radiographie standard, échographie, écho doppler

  19. Les infections à Pseudomonas aeruginosa au service des maladies infectieuses du CHU YO, Burkina Faso: à propos deux cas

    PubMed Central

    Mamoudou, Savadogo; Lassina, Dao; Fla, Koueta

    2015-01-01

    Nous rapportons deux cas d'infection à Pseudomonas aeruginosa: un cas de méningite et un cas d'infection urinaire. Les auteurs rappellent qu’à côté des étiologies classiques des méningites et des infections urinaires, des germes résistants comme Pseudomonas aeruginosa peuvent être responsables d'infections à localisation méningées et urinaires et dont il faut connaître pour une bonne prise en charge. Le traitement de ces infections requiert un antibiogramme au regard de la grande capacité de résistance de Pseudomonas aeruginosa en milieu hospitalier. La limitation des gestes invasifs et l'application rigoureuse des mesures de prévention des infections en milieu hospitalier contribueront à lutter efficacement contre ces infections en milieu de soins. PMID:26491521

  20. Gestresste Haut? - Aktueller Stand molekularer psychosomatischer Zusammenhänge und ihr Beitrag zu Ursachen und Folgen dermatologischer Erkrankungen.

    PubMed

    Peters, Eva M J

    2016-03-01

    In den 70er Jahren des vergangenen Jahrhunderts wurde zum ersten Mal ein pathogenetisch relevanter Zusammenhang zwischen Stress, im Sinne von psychosozialem Stress, und Krankheit am Beispiel von viralen Erkrankungen der Schleimhäute (wie Rhinovirus-, Coxsackie-Infektion) nachgewiesen. Seither nehmen Publikationen, die diese Zusammenhänge bis auf die molekulare Ebene erforschen, jährlich zu. Dennoch sind die Evidenzen für einen Einfluss von psychosozialer Belastung auf chronisch-entzündliche Hauterkrankungen und auf Hauttumoren wenig bekannt. In diesem Beitrag fassen wir die aktuellen Erkenntnisse aus Epidemiologie, Psychoneuroimmunologie und molekularer Psychosomatik narrativ zusammen. Sie belegen die vielfältigen krankheitsrelevanten Interaktionen zwischen endokrinem System, Nervensystem und Immunsystem. Im Fokus stehen stressinduzierte Verschiebungen in der Immunbalance bei ausgewählten Erkrankungen wie Neurodermitis, Psoriasis oder malignem Melanom. Ziel dieses Beitrages ist die Vermittlung psychosomatischen Grundlagenwissens bei chronischen Dermatosen. Dies reicht von der Ätiologie über die Symptomatik bis zu den therapeutischen Optionen. Besonderes Augenmerk liegt dabei auf den zugrunde liegenden molekularen Zusammenhängen sowohl aus der somatopsychischen als auch aus der psychosomatischen Perspektive. PMID:26972186

  1. A DES ASIC Suitable for Network Encryption at 10 Gbps and Beyond

    SciTech Connect

    Gass, Karl; Pierson, Lyndon G.; Robertson, Perry J.; Wilcox, D. Craig; Witzke, Edward L.

    1999-04-30

    The Sandia National Laboratories (SNL) Data Encryption Standard (DES) Application Specific Integrated Circuit (ASIC) is the fastest known implementation of the DES algorithm as defined in the Federal Information Processing Standards (FIPS) Publication 46-2. DES is used for protecting data by cryptographic means. The SNL DES ASIC, over 10 times faster than other currently available DES chips, is a high-speed, filly pipelined implementation offering encryption, decryption, unique key input, or algorithm bypassing on each clock cycle. Operating beyond 105 MHz on 64 bit words, this device is capable of data throughputs greater than 6.7 Billion bits per second (tester limited). Simulations predict proper operation up to 9.28 Billion bits per second. In low frequency, low data rate applications, the ASIC consumes less that one milliwatt of power. The device has features for passing control signals synchronized to throughput data. Three SNL DES ASICS may be easily cascaded to provide the much greater security of triple-key, triple-DES.

  2. Development of CPV solar receiver based on insulated metal substrate (IMS): Comparison with receiver based on the direct bonded copper substrate (DBC) - A reliability study

    NASA Astrophysics Data System (ADS)

    Mabille, Loïc; Mangeant, Christophe; Baudrit, Mathieu

    2012-10-01

    Most of the CPV solar receivers are based on III-V multijunction cells die-attached to a direct bonded copper (DBC) substrate. An alternative to DBC resides in the insulated metal substrate (IMS). This paper presents the behavior of IMS and DBC receivers when tested under accelerated aging conditions such as described in the IEC 62108. Characterization tools involved in the monitoring of potential degradation are electroluminescence (EL), dark-I (V) (DIV), spectral response (EQE), diode factor measurements (VIM), RX tomography (RX-T), and, of course, illuminated I (V) under various concentration factors. Based on EL, DIV and EQE first results, IMS and DBC age in a similar way. Study is ongoing.

  3. Direct Infusion Electrospray Ionization - Ion Mobility - High Resolution Mass Spectrometry (DIESI-IM-HRMS) for Rapid Characterization of Potential Bioprocess Streams

    NASA Astrophysics Data System (ADS)

    Munisamy, Sharon M.; Chambliss, C. Kevin; Becker, Christopher

    2012-07-01

    Direct infusion electrospray ionization - ion mobility - high resolution mass spectrometry (DIESI-IM-HRMS) has been utilized as a rapid technique for the characterization of total molecular composition in "whole-sample" biomass hydrolysates and extracts. IM-HRMS data reveal a broad molecular weight distribution of sample components (up to 1100 m/z) and provide trendline isolation of feedstock components from those introduced "in process." Chemical formulas were obtained from HRMS exact mass measurements (with typical mass error less than 5 ppm) and were consistent with structural carbohydrates and other lignocellulosic degradation products. Analyte assignments are supported via IM-MS collision-cross-section measurements and trendline analysis (e.g., all carbohydrate oligomers identified in a corn stover hydrolysate were found to fall within 6 % of an average trendline). These data represent the first report of collision cross sections for several negatively charged carbohydrates and other acidic species occurring natively in biomass hydrolysates.

  4. Processing and Properties of Fiber Reinforced Polymeric Matrix Composites. Part 2; Processing Robustness of IM7/PETI Polyimide Composites

    NASA Technical Reports Server (NTRS)

    Hou, Tan-Hung

    1996-01-01

    The processability of a phenylethynyl terminated imide (PETI) resin matrix composite was investigated. Unidirectional prepregs were made by coating an N-methylpyrrolidone solution of the amide acid oligomer onto unsized IM7. Two batches of prepregs were used: one was made by NASA in-house, and the other was from an industrial source. The composite processing robustness was investigated with respect to the effect of B-staging conditions, the prepreg shelf life, and the optimal processing window. Rheological measurements indicated that PETI's processability was only slightly affected over a wide range of B-staging temperatures (from 250 C to 300 C). The open hole compression (OHC) strength values were statistically indistinguishable among specimens consolidated using various B-staging conditions. Prepreg rheology and OHC strengths were also found not to be affected by prolonged (i.e., up to 60 days) ambient storage. An optimal processing window was established using response surface methodology. It was found that IM7/PETI composite is more sensitive to the consolidation temperature than to the consolidation pressure. A good consolidation was achievable at 371 C/100 Psi, which yielded an OHC strength of 62 Ksi at room temperature. However, processability declined dramatically at temperatures below 350 C.

  5. ESI-IMS-MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules.

    PubMed

    Young, Lydia M; Saunders, Janet C; Mahood, Rachel A; Revill, Charlotte H; Foster, Richard J; Ashcroft, Alison E; Radford, Sheena E

    2016-02-15

    Electrospray ionisation-ion mobility spectrometry-mass spectrometry (ESI-IMS-MS) is a powerful method for the study of conformational changes in protein complexes, including oligomeric species populated during protein self-aggregation into amyloid fibrils. Information on the mass, stability, cross-sectional area and ligand binding capability of each transiently populated intermediate, present in the heterogeneous mixture of assembling species, can be determined individually in a single experiment in real-time. Determining the structural characterisation of oligomeric species and alterations in self-assembly pathways observed in the presence of small molecule inhibitors is of great importance, given the urgent demand for effective therapeutics. Recent studies have demonstrated the capability of ESI-IMS-MS to identify small molecule modulators of amyloid assembly and to determine the mechanism by which they interact (positive, negative, non-specific binding, or colloidal) in a high-throughput format. Here, we demonstrate these advances using self-assembly of Aβ40 as an example, and reveal two new inhibitors of Aβ40 fibrillation. PMID:26007606

  6. Determination of Interlaminar Toughness of IM7/977-2 Composites at Temperature Extremes and Different Thicknesses

    NASA Technical Reports Server (NTRS)

    Johnson, W. S.; Pavlick, M. M.; Oliver, M. S.

    2005-01-01

    Composite materials are being used in the aerospace industry as a means of reducing vehicle weight. In particular, polymer matrix composites (PMC) are good candidates due to their high strength-to-weight and high stiffness-to-weight ratios. Future reusable space launch vehicles and space exploration structures will need advanced light weight composites in order to minimize vehicle weight while demonstrating robustness and durability, guaranteeing high factors of safety. In particular, the implementation of composite cryogenic propellant fuel tanks (cryotanks) for future reusable launch vehicles (RLVs) could greatly reduce the vehicle's weight versus identically sized cryotanks constructed of metallic materials. One candidate composite material for future cryotank designs is IM7/977-2, which is a graphite/epoxy system. A successful candidate must demonstrate reasonable structural properties over a wide range of temperatures. Since the matrix material is normally the weak link in the composite, tests that emphasize matrix-dominated behavior need to be conducted. Therefore, the objective of this work is to determine the mode I interlaminar fracture toughness of "unidirectional" 8-ply and 16-ply IM7/977-2 through experimental testing. Tests were performed at -196 degrees Celsius (-320 degrees Fahrenheit), 22 degrees Celsius (72 degrees Fahrenheit), 93 degrees Celsius (200 degrees Fahrenheit) and 160 degrees C (320 degrees Fahrenheit). Low temperature testing was completed while the specimen was submerged in a liquid nitrogen bath. High temperature testing was completed in a temperature-controlled oven.

  7. Identification of structurally closely related monosaccharide and disaccharide isomers by PMP labeling in conjunction with IM-MS/MS.

    PubMed

    Yang, Hongmei; Shi, Lei; Zhuang, Xiaoyu; Su, Rui; Wan, Debin; Song, Fengrui; Li, Jinying; Liu, Shuying

    2016-01-01

    It remains particularly difficult for gaining unambiguous information on anomer, linkage, and position isomers of oligosaccharides using conventional mass spectrometry (MS) methods. In our laboratory, an ion mobility (IM) shift strategy was employed to improve confidence in the identification of structurally closely related disaccharide and monosaccharide isomers using IMMS. Higher separation between structural isomers was achieved using 1-phenyl-3-methyl-5-pyrazolone (PMP) derivatization in comparison with phenylhydrazine (PHN) derivatization. Furthermore, the combination of pre-IM fragmentation of PMP derivatives provided sufficient resolution to separate the isomers not resolved in the IMMS. To chart the structural variation observed in IMMS, the collision cross sections (CCSs) for the corresponding ions were measured. We analyzed nine disaccharide and three monosaccharide isomers that differ in composition, linkages, or configuration. Our data show that coexisting carbohydrate isomers can be identified by the PMP labeling technique in conjunction with ion-mobility separation and tandem mass spectrometry. The practical application of this rapid and effective method that requires only small amounts of sample is demonstrated by the successful analysis of water-soluble ginseng extract. This demonstrated the potential of this method to measure a variety of heterogeneous sample mixtures, which may have an important impact on the field of glycomics. PMID:27306514

  8. Immunogenicity of IMS 1113 plus soluble subunit and chimeric proteins containing Mycoplasma hyopneumoniae P97 C-terminal repeat regions.

    PubMed

    Barate, Abhijit K; Cho, Youngjae; Truong, Quang Lam; Hahn, Tae-Wook

    2014-03-01

    The surface adhesin P97 mediates the adherence of Mycoplasma hyopneumoniae to swine cilia. Two reiterated repeats R1 and R2 are located at the C-terminus of P97. The purpose of this study was to evaluate the immunogenicity of Montanide adjuvant IMS 1113 plus soluble subunit proteins rR1, rR1R2 and their chimeric forms coupled with B subunit of the heat-labile enterotoxin of Escherichia coli (LTB). Each recombinant protein in this study was capable of eliciting anti-R1 specific humoral antibodies (IgG), mucosal antibodies (IgG and IgA) and IFN-γ production. The chimeric protein rLTBR1R2 elicited the quickest humoral antibody response among the recombinant proteins. Serum and bronchoalveolar lavage analysis revealed that each recombinant protein was capable of inducing both Th1 and Th2 responses. Importantly, all of the proteins induced an anti-R1-specific Th2-biased response in both humoral and mucosal compartments, similar to the response observed in a natural infection or vaccination process. These observations indicate that rR1, rR1R2, rLTBR1 and rLTBR1R2 with IMS 1113 might represent a promising subunit vaccine strategy against porcine enzootic pneumonia in pigs. PMID:24461070

  9. Demonstration of 2.97-Gb/s video signal transmissions in DML-based IM-DDO-OFDM systems

    NASA Astrophysics Data System (ADS)

    Chen, Ming; He, Jing; Deng, Rui; Chen, Qinghui; Zhang, Jinlong; Chen, Lin

    2016-05-01

    To further investigate the feasibility of the digital signal processing (DSP) algorithms (e.g., symbol timing synchronization, channel estimation and equalization, and sampling clock frequency offset (SCFO) estimation and compensation) for real-time optical orthogonal frequency-division multiplexing (OFDM) system, 2.97-Gb/s real-time high-definition video signal parallel transmission is experimentally demonstrated in OFDM-based short-reach intensity-modulated direct-detection (IM-DD) systems. The experimental results show that, in the presence of ∼12 ppm SCFO between transmitter and receiver, the adaptively modulated OFDM signal transmission over 20 km standard single-mode fiber with an error bit rate less than 1 × 10-9 can be achieved by using only DSP-based small SCFO estimation and compensation method without utilizing forward error correction technique. To the best of our knowledge, for the first time, we successfully demonstrate that the video signal at a bit rate in excess of 1-Gb/s transmission in a simple real-valued inverse fast Fourier transform and fast Fourier transform based IM-DD optical OFDM system employing a directly modulated laser.

  10. VLBI FOR GRAVITY PROBE B. VI. THE ORBIT OF IM PEGASI AND THE LOCATION OF THE SOURCE OF RADIO EMISSION

    SciTech Connect

    Ransom, R. R.; Bartel, N.; Bietenholz, M. F.; Lebach, D. E.; Ratner, M. I.; Shapiro, I. I.; Lestrade, J.-F.

    2012-07-01

    We present a physical interpretation for the locations of the sources of radio emission in IM Pegasi (IM Peg, HR 8703), the guide star for the NASA/Stanford relativity mission Gravity Probe B. This emission is seen in each of our 35 epochs of 8.4 GHz very long baseline interferometry observations taken from 1997 to 2005. We found that the mean position of the radio emission is at or near the projected center of the primary to within about 27% of its radius, identifying this active star as the radio emitter. The positions of the radio brightness peaks are scattered across the disk of the primary and slightly beyond, preferentially along an axis with position angle, P.A. = -38 Degree-Sign {+-} 8 Degree-Sign , which is closely aligned with the sky projections of the orbit normal (P.A. = -49.{sup 0}5 {+-} 8.{sup 0}6) and the expected spin axis of the primary. Comparison with simulations suggests that brightness peaks are 3.6{sup +0.4}{sub -0.7} times more likely to occur (per unit surface area) near the pole regions of the primary (latitude, |{lambda}| {>=} 70 Degree-Sign ) than near the equator (|{lambda}| {<=} 20 Degree-Sign ), and to also occur close to the surface with {approx}2/3 of them at altitudes not higher than 25% of the radius of the primary.

  11. Identification of structurally closely related monosaccharide and disaccharide isomers by PMP labeling in conjunction with IM-MS/MS

    PubMed Central

    Yang, Hongmei; Shi, Lei; Zhuang, Xiaoyu; Su, Rui; Wan, Debin; Song, Fengrui; Li, Jinying; Liu, Shuying

    2016-01-01

    It remains particularly difficult for gaining unambiguous information on anomer, linkage, and position isomers of oligosaccharides using conventional mass spectrometry (MS) methods. In our laboratory, an ion mobility (IM) shift strategy was employed to improve confidence in the identification of structurally closely related disaccharide and monosaccharide isomers using IMMS. Higher separation between structural isomers was achieved using 1-phenyl-3-methyl-5-pyrazolone (PMP) derivatization in comparison with phenylhydrazine (PHN) derivatization. Furthermore, the combination of pre-IM fragmentation of PMP derivatives provided sufficient resolution to separate the isomers not resolved in the IMMS. To chart the structural variation observed in IMMS, the collision cross sections (CCSs) for the corresponding ions were measured. We analyzed nine disaccharide and three monosaccharide isomers that differ in composition, linkages, or configuration. Our data show that coexisting carbohydrate isomers can be identified by the PMP labeling technique in conjunction with ion-mobility separation and tandem mass spectrometry. The practical application of this rapid and effective method that requires only small amounts of sample is demonstrated by the successful analysis of water-soluble ginseng extract. This demonstrated the potential of this method to measure a variety of heterogeneous sample mixtures, which may have an important impact on the field of glycomics. PMID:27306514

  12. Etude experimentale de la photoexcitation des colorants de type anthracene, azobenzene et thioindigo dans des matrices de cristaux liquides nematiques et smectiques

    NASA Astrophysics Data System (ADS)

    Saad, Bendaoud

    Nous avons étudié le comportement de différents colorants (tétracène et azobenzènes AZD3, DR1 et D2) dans des matrices de cristaux liquides (E7 et 5CB). Les résultats obtenus ont montré que la réorientation optique des molécules de cristaux liquides se produit à des intensités extrêmement faibles (~1 μW/cm 2). Nous avons attribué cet effet à l'interaction entre les molécules des colorants photoexcitées et celles des cristaux liquides hôtes. Ces interactions se produisent lorsque les molécules dichroïques exçitées transitent entre des états triplets intermédiaires tout en conduisant à la génération d'un nouveau moment optique géant, responsable de la réorientation des molécules. Le changement de la forme de la molécule du colorant, dû à l'isomérisation Trans-Cis , est à l'origine de la création de ce moment. Ce qui distingue notre réorientation moléculaire de celle obtenue sur d'autres systèmes hôtes-dopants est que les molécules sont repoussées du champ électrique de la lumière. Par ailleurs, cette réorientation est accompagnée d'une diffusion anisotrope des molécules excitées. Nous avons aussi étudié le cristal liquide PhBz rendu ferroélectrique en le dopant par des molécules thioindigos. En exploitant l'augmentation de la polarisation spontanée due à la photoisomérisation du colorant, nous avons pu réaliser un hologramme dynamique contrôlable par un champ optique assisté par une tension statique.

  13. The Applicability of Incoherent Array Processing to IMS Seismic Array Stations

    NASA Astrophysics Data System (ADS)

    Gibbons, S. J.

    2012-04-01

    nuclear tests but, due to signal incoherence, failed to contribute to the automatic event detections. It is demonstrated that the smoothed incoherent slowness estimates for the MJAR Pn phases for both tests indicate unambiguously the correct type of phase and a backazimuth estimate within 5 degrees of the great-circle backazimuth. The detection part of the algorithm is applicable to all IMS arrays, and spectrogram-based processing may offer a reduction in the false alarm rate for high frequency signals. Significantly, the local maxima of the scalar functions derived from the transformed spectrogram beams provide good estimates of the signal onset time. High frequency energy is of greater significance for lower event magnitudes and in, for example, the cavity decoupling detection evasion scenario. There is a need to characterize propagation paths with low attenuation of high frequency energy and situations in which parameter estimation on array stations fails.

  14. Molecular evolution of peste des petits ruminants virus.

    PubMed

    Muniraju, Murali; Munir, Muhammad; Parthiban, AravindhBabu R; Banyard, Ashley C; Bao, Jingyue; Wang, Zhiliang; Ayebazibwe, Chrisostom; Ayelet, Gelagay; El Harrak, Mehdi; Mahapatra, Mana; Libeau, Geneviève; Batten, Carrie; Parida, Satya

    2014-12-01

    Despite safe and efficacious vaccines against peste des petits ruminants virus (PPRV), this virus has emerged as the cause of a highly contagious disease with serious economic consequences for small ruminant agriculture across Asia, the Middle East, and Africa. We used complete and partial genome sequences of all 4 lineages of the virus to investigate evolutionary and epidemiologic dynamics of PPRV. A Bayesian phylogenetic analysis of all PPRV lineages mapped the time to most recent common ancestor and initial divergence of PPRV to a lineage III isolate at the beginning of 20th century. A phylogeographic approach estimated the probability for root location of an ancestral PPRV and individual lineages as being Nigeria for PPRV, Senegal for lineage I, Nigeria/Ghana for lineage II, Sudan for lineage III, and India for lineage IV. Substitution rates are critical parameters for understanding virus evolution because restrictions in genetic variation can lead to lower adaptability and pathogenicity. PMID:25418782

  15. Use of DES Modeling for Determining Launch Availability for SLS

    NASA Technical Reports Server (NTRS)

    Watson, Michael; Staton, Eric; Cates, Grant; Finn, Ronald; Altino, Karen M.; Burns, K. Lee

    2014-01-01

    (1) NASA is developing a new heavy lift launch system for human and scientific exploration beyond Earth orbit comprising of the Space Launch System (SLS), Orion Multi-Purpose Crew Vehicle (MPCV), and Ground Systems Development and Operations (GSDO); (2) The desire of the system is to ensure a high confidence of successfully launching the exploration missions, especially those that require multiple launches, have a narrow Earth departure window, and high investment costs; and (3) This presentation discusses the process used by a Cross-Program team to develop the Exploration Systems Development (ESD) Launch Availability (LA) Technical Performance Measure (TPM) and allocate it to each of the Programs through the use of Discrete Event Simulations (DES).

  16. Commande optimale à flux libre des machines asynchrones

    NASA Astrophysics Data System (ADS)

    Biedinger, J. M.; Poullain, S.; Yvon, J. P.

    1992-01-01

    The subject of this paper is the optimal control with unconstrained flux of an induction motor being considered as a distributed parameter system described by a nonlinear diffusion equation. This approach allows to describe the electrodynamic state of the motor by taking into account, in a natural way, the influence of saturation and eddy-currents, as well as the nonlinearities due to the variable flux operation. Equations are approximated via a finite element formulation which leads to a finite dimensional dynamical system to which the techniques of optimal control may be applied. The generality of the methodology allows to treat various criteria. The objective aimed in this paper is to force the motor torque to follow a given input, especially under initially demagnetized conditions and with, naturally, constraints on the currents. For this purpose the criterion will be chosen as a norm of the difference between the electromagnetic torque and a given reference torque. Numerical simulations are presented for the case of a squirrel-cage rotor and for a solid iron rotor. Results are compared with those deduced from strategies based on lumped-parameter models. Torque responses obtained with field-oriented control method adapted to the case of flux-variable operation are also presented. Finally a modification of the criterion is proposed for identifying the command which allows to obtain the larger torque during transient states. Dans cet article on traite le problème du contrôle optimal à flux libre d'un moteur asynchrone considéré comme un système à paramètres répartis gouverné par une équation de diffusion non linéaire. Cette approche permet de décrire l'état électrodynamique de la machine en prenant naturellement en compte les effets de la saturation et des courants induits, ainsi que les non-linéarités liées au fonctionnement à flux variable. La formulation éléments finis est utilisée pour traduire le problème continu sous la forme d

  17. Experimental Results in DIS, SIDIS and DES from Jefferson Lab

    SciTech Connect

    Kuhn, Sebastian E.

    2011-07-15

    Jefferson Lab's electron accelerator in its present incarnation, with a maximum beam energy slightly above 6 GeV, has already enabled a large number of experiments expanding our knowledge of nucleon and nuclear structure (especially in Deep Inelastic Scattering--DIS--at moderately high x, and in the resonance region). Several pioneering experiments have yielded first results on Deeply Virtual Compton Scattering (DVCS) and other Deep Exclusive Processes (DES), and the exploration of the rich landscape of transverse momentum-dependent (TMD) structure functions using Semi-Inclusive electron scattering (SIDIS) has begun. With the upgrade of CEBAF to 12 GeV now underway, a significantly larger kinematic space will become available. The 12 GeV program taking shape will complete a detailed mapping of inclusive, TMD and generalized distribution functions for quarks, antiquarks and gluons in the valence region and beyond.

  18. Experimental Results in DIS, SIDIS and DES from Jefferson Lab

    SciTech Connect

    Sebastian Kuhn

    2011-07-01

    Jefferson Lab's electron accelerator in its present incarnation, with a maximum beam energy slightly above 6 GeV, has already enabled a large number of experiments expanding our knowledge of nucleon and nuclear structure (especially in Deep Inelastic Scattering—DIS—at moderately high x, and in the resonance region). Several pioneering experiments have yielded first results on Deeply Virtual Compton Scattering (DVCS) and other Deep Exclusive Processes (DES), and the exploration of the rich landscape of transverse momentum-dependent (TMD) structure functions using Semi-Inclusive electron scattering (SIDIS) has begun. With the upgrade of CEBAF to 12 GeV now underway, a significantly larger kinematic space will become available. The 12 GeV program taking shape will complete a detailed mapping of inclusive, TMD and generalized distribution functions for quarks, antiquarks and gluons in the valence region and beyond.

  19. Statistique des photons d'un laser à 4 niveaux soumis à un pompage optique

    NASA Astrophysics Data System (ADS)

    Chusseau, L.; Arnaud, J.; Philippe, F.

    2002-06-01

    Les lasers conventionnels à 4 niveaux peuvent délivrer de la lumière de statistique sous-Poissonienne même lorsqu'ils sont soumis à un pompage optique. Nous retrouvons exactement ces prédictions de l'optique quantique en supposant simplement que les atomes ont des niveaux d'énergie quantifiés interagissant avec un champ électromagnétique classique, la source du bruit optique étant les sauts quantiques entre niveaux. Des formules analytiques sont obtenues pour les deux paramètres clefs de la statistique des photons du laser: le facteur de Fano et la densité spectrale des photons émis.

  20. Soins primaires des personnes victimes d’une lésion médullaire

    PubMed Central

    McColl, Mary Ann; Aiken, Alice; McColl, Alexander; Sakakibara, Brodie; Smith, Karen

    2012-01-01

    Résumé Objectif Effectuer une étude de la portée des données empiriques, entre 1980 et 2009, concernant les soins primaires aux adultes victimes d’une lésion médullaire (LME). Sources des données Une recension dans des revues révisées par des pairs de1980 à 2009 à l’aide de CINAHL, PubMed-MEDLINE, EMBASE, PsycINFO, Social Sciences Abstracts et Social Work Abstracts. Sélection des études La recherche électronique au moyen de mots-clés a permis de cerner 42 articles sur les soins primaires et les LME. Des critères d’inclusion ont servi à réduire la liste à un ensemble de 21 articles publiés en anglais qui portaient sur un échantillon de plus de 3 et présentaient une analyse empirique. Synthèse Environ 90 % des personnes atteintes d’une LME ont identifié leur médecin de famille comme étant leur docteur habituel; 63 % avaient un spécialiste des LME. Les personnes vivant à long terme avec une LME développent des rubriques complexes pour naviguer dans leurs systèmes de soins de santé personnels. Les données scientifiques ne sont pas unanimes quant à l’efficacité des programmes d’intervention directe pour le maintien de la santé et la prévention des complications à la suite d’une LME. Les données appuient cependant le suivi périodique par une équipe spécialisée et un bilan de santé annuel complet. La recherche fait valoir un fort degré d’uniformité dans l’identification des problèmes les plus courants soulevés par les personnes atteintes d’une LME en soins primaires, dont la plupart concernent l’incapacité, plus précisément les complications secondaires, comme la dysfonction intestinale ou vésicale et la douleur. Il existe aussi de bonnes données probantes à l’effet que de nombreux problèmes de santé généraux exigent de l’attention dans une telle population, comme les problèmes de la densité osseuse, la dépression et les questions entourant la santé sexuelle et la reproduction. Il y a