Science.gov

Sample records for imaging program cip

  1. Health Sciences. Program CIP: 51.0000

    ERIC Educational Resources Information Center

    Murdock, Ashleigh, Ed.

    2007-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  2. Polymer Science. Program CIP: 15.0607

    ERIC Educational Resources Information Center

    Research and Curriculum Unit, 2010

    2010-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  3. Marketing. Program CIP: Marketing: 52.1801

    ERIC Educational Resources Information Center

    Murdock, Ashleigh Barbee, Ed.

    2008-01-01

    Secondary career-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  4. Specialized Initiatives - Cancer Imaging Program

    Cancer.gov

    CIP has sponsored a number of programs for specific purposes, using set-aside funds. Among these are Phase 2 N01 ProgramIn-Vivo Cellular & Molecular Imaging Centers (ICMICs) Quantitative Imaging for Evaluation of Responses to Cancer Therapies (QIN) Network for Translational Research (NTR): Optical Imaging in Multimodal Platforms Small Animal Imaging Resource Program (SAIRP) Development of Preclinical Drugs and Enhancers (DCIDE) program.

  5. Efficacy of the Social Skills Improvement System Classwide Intervention Program (SSIS-CIP) Primary Version

    ERIC Educational Resources Information Center

    DiPerna, James Clyde; Lei, Puiwa; Bellinger, Jillian; Cheng, Weiyi

    2015-01-01

    A multisite cluster randomized trial was conducted to examine the effects of the Social Skills Improvement System Classwide Intervention Program (SSIS-CIP; Elliott & Gresham, 2007) on students' classroom social behavior. The final sample included 432 students across 38 second grade classrooms. Social skills and problem behaviors were measured…

  6. Single Institution Feasibility Trials - Cancer Imaging Program

    Cancer.gov

    Within the CIP program, the current R21 mechanism provides potential funding for small, single institution feasibility trials. The current announcement is titled In Vivo Cancer Imaging Exploratory/Developmental Grants.

  7. Phase 2 N01 Program - Cancer Imaging Program

    Cancer.gov

    The Phase 2 N01 Program is a CTEP-CIP collaboration includes 7 contractors, most of whom consist of multi-institutional consortia, and includes a total of 22 NCI-designated Cancer Centers. These sites carry out early clinical trials with CTEP and CIP-held IND agents, with an emphasis on phase 2 trials, but including phase 1 trials as well. These trials include the evaluation of novel imaging agents and methods to enhance the evaluation of novel therapeutics.

  8. Early Childhood Education. Program CIP: 19.0709

    ERIC Educational Resources Information Center

    Murdock, Ashleigh Barbee, Ed.

    2010-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  9. Welding Technology. Program CIP: 48.0508 - WELDING

    ERIC Educational Resources Information Center

    Ferguson, Doug

    2010-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  10. Business Fundamentals. Program CIP: Business Fundamentals: 52.0101

    ERIC Educational Resources Information Center

    Murdock, Ashleigh Barbee, Ed.

    2008-01-01

    Secondary career-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  11. Installation and Service: HVAC. Program CIP: 47.0201

    ERIC Educational Resources Information Center

    Research and Curriculum Unit, 2009

    2009-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  12. Simulation and Animation Design. Program CIP: 50.0411

    ERIC Educational Resources Information Center

    Murdock, Ashleigh Barbee, Ed.

    2010-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  13. Digital Media Technology. Program CIP: 09.0702

    ERIC Educational Resources Information Center

    Agee, Kelly, Ed.

    2009-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  14. Industrial Maintenance. Program CIP: 47.0303 - Industrial Maintenance

    ERIC Educational Resources Information Center

    Research and Curriculum Unit, 2009

    2009-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  15. Diesel Service Technician. Program CIP: 47.0605

    ERIC Educational Resources Information Center

    Agee, Kelly, Ed.

    2010-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  16. Management. Program CIP: Business Management: 52.0204

    ERIC Educational Resources Information Center

    Murdock, Ashleigh Barbee, Ed.

    2008-01-01

    Secondary career-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  17. Culinary Arts. Program CIP: 12.0500-Culinary Arts

    ERIC Educational Resources Information Center

    Murdock, Ashleigh, Ed.

    2008-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  18. Automotive Service Technician. Program CIP: 47.0604 - Transportation

    ERIC Educational Resources Information Center

    Agee, Kelly, Ed.

    2008-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  19. Mesospheric Zonal Mean Winds Derived from Consecutive Orbits of AIM Cips Images

    NASA Astrophysics Data System (ADS)

    Rong, P. P.; Yue, J.; Russell, J. M., III; Lumpe, J. D., Jr.; Gong, J.; Wu, D. L.; Randall, C. E.

    2014-12-01

    In order to infer mesospheric wind velocities, polar mesospheric cloud (PMC) pattern variations are investigated using images from consecutive orbits taken by the Cloud Imaging and Particle Size instrument (CIPS) aboard the AIM satellite. CIPS measurements are analyzed to detect patterns that repeat from one orbit to the next, but are displaced in location; the displacement provides a measure of the wind velocity. Pattern matching is achieved by re-sampling the CIPS data to a standard geographic grid with a horizontal resolution of 0.2° longitude × 0.05° latitude (~25 km2), and correlating patterns within geographic frames of size 24° longitude × 3.6° latitude. Such a frame size is arbitrarily chosen, but it covers a hierarchy of cloud structures including scales as large as several hundred kilometers. A relatively larger frame is required because after ~90 minutes, the time of one orbit, the smaller scale features are no longer conserved. Several thousand pairs, taken from 10-14 July 2007, are matched to derive the statistics. These pairs are mostly evenly distributed at longitudes and latitudes north of 70⁰N for each given day. The results suggest that the zonal velocity probability distribution during this 5-day period was peaked at around -40m/s with a 1-σ scatter of ~35m/s. The meridional velocity distribution peaked at 0 m/s with a 1-σ scatter of ~25m/s. These prevailing velocities can be determined with high precision because the corresponding patterns are shifted by at least half of the frame size from one orbit to the next. The CIPS cloud albedo on consecutive orbits is also examined for variations at fixed locations. The statistical results suggest that the mean cloud albedo within a given frame will most likely be weakened or strengthened by < 30% on consecutive orbits, although larger variations can occur with lower probability. Such a conclusion applies to both bright and dim clouds. This indicates that within 90 minutes the cloud brightness

  20. Mississippi Curriculum Framework for Horticulture Technology Cluster (Program CIP: 01.0601--Horticulture Serv. Op. & Mgmt., Gen.) (Program CIP: 01.0605--Landscaping Op. & Mgmt.). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the horticulture technology programs cluster. Presented in the introductory section are a framework of programs and courses, description of the programs, and suggested course sequences for…

  1. Mississippi Curriculum Framework for Emergency Medical Technology--Basic (Program CIP: 51.0904). Emergency Medical Technology--Paramedic (Program CIP: 51.0904). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the emergency medical technology (EMT) programs cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline…

  2. Mississippi Curriculum Framework for Drafting and Design Technology (Program CIP: 48.0102--Architectural Drafting Technology) (Program CIP: 48.0101--General Drafting). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the two course sequences of the state's postsecondary-level drafting and design technology program: architectural drafting technology and drafting and design technology. Presented first are a program description and…

  3. Mississippi Curriculum Framework for Residential Carpentry Technology (Program CIP: 46.0201--Carpenter). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for certificate of residential carpentry and residential carpentry technology programs. Presented in the introductory section are program descriptions and suggested course sequences for both programs. Section I lists…

  4. Information Systems - Cancer Imaging Program

    Cancer.gov

    The Lung Image Database Consortium (LIDC) represents an effort by CIP grantees in a consortium to create a database of spiral CT images of the lung for use in CAD (computer-aided detection) algorithm research. The Imaging Database Resources Initiative (IDRI) is extending the efforts of the LIDC, to create a larger database of spiral CT imaging of the lung for use in CAD algorithm research. Image Archive Resources contains links to Web sites related to the interests of the NCI CIP Image Archive Committee. The Molecular Imaging and Contrast Agent Database (MICAD) is a database of research data on in vivo molecular imaging and contrast agents.

  5. Mississippi Curriculum Framework for Welding (Program CIP: 48.0508--Welder/Welding Technologist). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for welding I and II. Presented first are a program description and course…

  6. Mississippi Curriculum Framework for Agriscience (Program CIP: 02.0101--Agriculture Science). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for agriscience I and II. Presented first are a program description and…

  7. Mississippi Curriculum Framework for Automotive Machinist (Program CIP: 47.0690--Auto Machinist). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the automotive machinist programs cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies, and…

  8. Mississippi Curriculum Framework for Allied Health (Program CIP: 51.1699--Nursing, Other). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for allied health I and II. Presented first are a program description and…

  9. Mississippi Curriculum Framework for General Drafting (Program CIP: 48.0101--Drafting, General). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for two secondary-level courses in drafting: drafting I and II. Presented…

  10. Mississippi Curriculum Framework for Metal Trades (Program CIP: 48.0590--Metal Trades). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for metal trades I, IIA (advanced welding), and IIB (advanced machine shop).…

  11. Mississippi Curriculum Framework for Building Trades (Program CIP: 46.0490--Building Trades, General). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for two secondary-level courses in the building trades: building trades I and…

  12. Mississippi Curriculum Framework for Residential Carpentry (Program CIP: 46.0201--Carpenter). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for two secondary-level courses in carpentry: carpentry I and II. Presented…

  13. Mississippi Curriculum Framework for Electronics (Program CIP: 47.0190--Electronics (Secondary)). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for two secondary-level courses in electronics: electronics I and II.…

  14. Mississippi Curriculum Framework for Electrician (Program CIP: 46.0302--Electrician). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for secondary-level courses to prepare Mississippi vocational students for…

  15. Mississippi Curriculum Framework for Sheet Metal Programs (Program CIP: 48.0506--Sheet Metal Worker). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document provides the framework for a postsecondary sheet metal program of instruction. A foreword provides guidelines that were used in developing the program and should be considered in compiling and revising course syllabi and daily lesson plans at the local level. A description of the sheet metal programs (building trades sheet metal work…

  16. Mississippi Curriculum Framework for Physical Therapist Assistant (CIP: 51.0806--Physical Therapy Assistant). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the physical therapy assistant program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies, and section…

  17. Mississippi Curriculum Framework for Dental Hygiene Technology (Program CIP: 51.0602--Dental Hygienist). Postsecondary Education.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the dental hygiene technology program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies. Section II…

  18. Mississippi Curriculum Framework for Welding and Cutting Programs (Program CIP: 48.0508--Welder/Welding Technologist). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the welding and cutting programs cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies, and…

  19. Mississippi Curriculum Framework for Banking & Finance Technology (Program CIP: 52.0803--Banking and Related Financial Programs, Other). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the banking and finance technology program. Presented in the introduction are a program description and suggested course sequence. Section I is a curriculum guide consisting of outlines for…

  20. Mississippi Curriculum Framework for Dental Assisting Technology Programs (Program CIP: 51.0601--Dental Assistant). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the dental assisting technology program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies. Section II…

  1. CIPS Validation Data Plan

    SciTech Connect

    Nam Dinh

    2012-03-01

    This report documents analysis, findings and recommendations resulted from a task 'CIPS Validation Data Plan (VDP)' formulated as an POR4 activity in the CASL VUQ Focus Area (FA), to develop a Validation Data Plan (VDP) for Crud-Induced Power Shift (CIPS) challenge problem, and provide guidance for the CIPS VDP implementation. The main reason and motivation for this task to be carried at this time in the VUQ FA is to bring together (i) knowledge of modern view and capability in VUQ, (ii) knowledge of physical processes that govern the CIPS, and (iii) knowledge of codes, models, and data available, used, potentially accessible, and/or being developed in CASL for CIPS prediction, to devise a practical VDP that effectively supports the CASL's mission in CIPS applications.

  2. 2005 Mississippi Curriculum Framework: Secondary Cosmetology. (Program CIP: 12.0401 - Cosmetology/Cosmetologist, General)

    ERIC Educational Resources Information Center

    Buchanon, Rouser; Farmer, Helen

    2005-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  3. 2005 Mississippi Curriculum Framework: Secondary Metal Trades. (Program CIP: 48.0590 - Metal Trades)

    ERIC Educational Resources Information Center

    Brown, Gary; Sample, John; Waits, Jeffrey; Britt, Albert; McKee, Steve; Sullivan, Kirk; Warren, Brian

    2005-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  4. 2005 Mississippi Curriculum Framework: Secondary Aging Services. (Program CIP: 19.0702 - Adult Development and Aging)

    ERIC Educational Resources Information Center

    Walker, Kathy

    2005-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  5. 2007 Mississippi Curriculum Framework: Secondary Introduction to Agriscience. (Program CIP: 01.0001 - Introduction to Agriscience)

    ERIC Educational Resources Information Center

    Research and Curriculum Unit, 2007

    2007-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  6. 2007 Mississippi Curriculum Framework: Secondary Agriscience. (Program CIP: 01.0000 - Agriculture, General)

    ERIC Educational Resources Information Center

    Cantrell, Steve; Conway, Scott; Jack, Linda; Stuckey, Dan

    2007-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  7. Information Technology. Program CIP: 11.0101 Computer Technology/Computer Systems Technology

    ERIC Educational Resources Information Center

    Agee, Kelly, Ed.

    2009-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  8. 2006 Mississippi Curriculum Framework: Secondary Forestry. (Program CIP: 03.0511 - Forestry Technology/Technician)

    ERIC Educational Resources Information Center

    Research and Curriculum Unit, 2006

    2006-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  9. 2005 Mississippi Curriculum Framework: Secondary Building Trades. (Program CIP: 46.0000 - Construction Trades, General)

    ERIC Educational Resources Information Center

    Jernigan, Jarvis; Manning, Phillip; Matkins, Billy

    2005-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  10. Construction: Carpentry Concentration. Program CIP: 46.0000 Construction: Carpentry Concentration

    ERIC Educational Resources Information Center

    Agee, Kelly, Ed.

    2008-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  11. 2007 Mississippi Curriculum Framework: Secondary Computer Graphics. (Program CIP: 50.0402 - Commercial and Advertising Art)

    ERIC Educational Resources Information Center

    Creel, Jo Anne; Denson, Cornelius; New, Ray

    2007-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  12. 2005 Mississippi Curriculum Framework: Secondary Masonry. (Program CIP: 46.0101 - Mason/Masonry)

    ERIC Educational Resources Information Center

    Davis, Milton; Harris, Chester; Richards, Toney; Smith, Allen; Weatherly, Ronald; Weeks, W. D.

    2005-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  13. Mississippi Curriculum Framework for Surgical Technology Programs (CIP: 51.0909--Surgical/Operating Room Tech.). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the surgical technology program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies for the program,…

  14. Mississippi Curriculum Framework for Horticulture (Program CIP: 01.0601--Horticulture Serv. Op. & Mgmt., Gen.). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for horticulture I and II. Presented first are a program description and…

  15. Mississippi Curriculum Framework for Practical Nursing Programs CIP: 51.1613--Practical Nurse (L.P.N. Training). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the practical nursing program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies, and section II…

  16. Mississippi Curriculum Framework for Introduction to Agriscience (Program CIP: 02.9990--Introduction to Agriculture Science). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for the introduction to agriscience program. Presented first are a program…

  17. Mississippi Curriculum Framework for Veterinary Technology (Program CIP: 51.0808--Veterinarian Asst./Animal Health). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the veterinary technology program. Presented in the introductory section are a of the program and suggested course sequence. Section I lists baseline competencies, and section II consists of…

  18. Mississippi Curriculum Framework for Forestry Technology (Program CIP: 03.0401--Forest Harvesting and Production Technology). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the forestry technology program cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies for the…

  19. Mississippi Curriculum Framework for Fashion Marketing Technology (Program CIP: 08.0101--Apparel and Accessories Mkt. Op., Gen.). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the fashion marketing technology programs cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies,…

  20. Mississippi Curriculum Framework for Automotive Mechanics (Program CIP: 47.0604--Auto/Automotive Mechanic/Tech). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for automotive mechanics I and II. Presented first are a program description…

  1. Mississippi Curriculum Framework for Brick, Block, and Stonemasonry (Program CIP: 46.0101--Mason and Tile Setter). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the brick, block, and stonemasonry program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies for the…

  2. Mississippi Curriculum Framework for Ophthalmic Technology (Program CIP: 51.1801--Opticianry/Dispensing Optician). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the ophthalmic technology program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies, and section II…

  3. Mississippi Curriculum Framework for Civil Technology (Program CIP: 15.0201--Civil Engineering/Civil Technology). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the civil technology programs cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies, and section…

  4. Mississippi Curriculum Framework for Automotive Technology Programs (CIP: 47.0604--Automotive Mechanic/Tech.). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the automotive technology programs cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies, and…

  5. Mississippi Curriculum Framework for Forestry (Program CIP: 03.0401--Forest Harvesting and Production Technology). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for forestry I and II. Presented first are a program description and course…

  6. Mississippi Curriculum Framework for Plumber and Pipefitter/Steamfitter (Program CIP: 46.0501--Plumber and Pipefitter). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the plumber and pipefitter/steamfitter cluster. Presented in the introductory section are program descriptions and suggested course sequences for the plumbing and pipefitting programs. Section…

  7. Mississippi Curriculum Framework for Medical Laboratory Technology Programs (CIP: 51.1004--Medical Laboratory Technology). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the medical laboratory technology program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies, and…

  8. Mississippi Curriculum Framework for Marketing Management Technology (Program CIP: 52.1401--Business Mkt. & Mkt. Mgmt.). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the state's marketing management technology program. Presented in the introduction are a program description and suggested course sequence. Section I lists baseline competencies for the…

  9. Mississippi Curriculum Framework for Respiratory Care Technology Programs (CIP: 51.0908--Respiratory Therapy Technology). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the respiratory care technology program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies, and…

  10. Mississippi Curriculum Framework for Postsecondary Child Development Technology Programs (CIP: 20.0201--Child Care & Guidance Workers & Mgr). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the child development technology programs cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies,…

  11. Mississippi Curriculum Framework for Postsecondary Teacher Assistant Programs (CIP: 13.1501--Teacher Assistant/Aide). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the teacher assistant program. Presented in the introduction are a program description and suggested course sequence. Section I is a curriculum guide consisting of outlines for each of the…

  12. Mississippi Curriculum Framework for Collision Repair Technology (Program CIP: 47.0603--Auto/Autobody Repair). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the collision repair technology programs cluster. Presented in the introductory section are a description of the program and suggested course sequences for 1- and 2-year certificates. Section…

  13. Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1).

    PubMed

    Göke, R; Barth, P; Schmidt, A; Samans, B; Lankat-Buttgereit, B

    2004-12-01

    We show that the recently discovered tumor suppressor pdcd4 represses the transcription of the mitosis-promoting factor cyclin-dependent kinase (CDK)1/cdc2 via upregulation of p21(Waf1/Cip1). p21(Waf1/Cip1) inhibits CDK4/6 and CDK2. Decrease of CDK4/6 and CDK2 enhances the binding of pRb to E2F/DP, which in turn together bind to and repress the cdc2 promoter. Upregulation of CDK1/cdc2 accompanied by a malignant change was previously reported in colon cancer. We show that expression of pdcd4 as an indirect suppressor of CDK1/cdc2 is lost in progressed carcinomas of lung, breast, colon, and prostate. Furthermore, it seems that localization and expression of pdcd4 directly correlate with tumor progression. Finally, the CDK1/cdc2 inhibitor roscovitine reduces the proliferation of several tumor cell lines, suggesting that inhibition of CDK1/cdc2 may be a useful strategy against malignant transformation. Therefore, pdcd4 might serve as a novel target for antineoplastic therapies. PMID:15317660

  14. Mississippi Curriculum Framework for Machine Tool Operation/Machine Shop (Program CIP: 48.0503--Machine Shop Assistant). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for machine tool operation/machine shop I and II. Presented first are a…

  15. Mississippi Curriculum Framework for Automotive Body Repair (Program CIP: 47.0603--Auto/Automotive Body Repairer). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for automotive body repair I and II. Presented first are a program…

  16. Mississippi Curriculum Framework for Marketing and Fashion Merchandising (Program CIP: 08.0705--General Retailing Operations). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for marketing I-II and fashion merchandising. Presented first are a program…

  17. Mississippi Curriculum Framework for Agriculture Production (Program CIP: 01.0301--Agricultural Prod. Workers & Mgrs.). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for agriculture production I and II. Presented first are a program…

  18. Mississippi Curriculum Framework for Agriculture Business and Management (Program CIP: 01.0101--Agriculture Business & Mgmt., Gen.). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for agriculture business and management (ABM) I and II. Presented first are a…

  19. Mississippi Curriculum Framework for Diesel Equipment Repair & Service (Program CIP: 47.0605--Diesel Engine Mechanic & Repairer). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for diesel engine mechanics I and II. Presented first are a program…

  20. Mississippi Curriculum Framework for Brick, Block, and Stonemasonry (Program CIP: 46.0101--Mason and Tile Setter). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for two secondary-level courses in brick, block, and stonemasonry: brick,…

  1. Mississippi Curriculum Framework for Graphics and Print Communications (Program CIP: 48.0201--Graphic and Printing Equipment Operators). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for secondary-level courses in graphics and print communications I-II.…

  2. Mississippi Curriculum Framework for Computer Information Systems Technology. Computer Information Systems Technology (Program CIP: 52.1201--Management Information Systems & Business Data). Computer Programming (Program CIP: 52.1201). Network Support (Program CIP: 52.1290--Computer Network Support Technology). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for two programs in the state's postsecondary-level computer information systems technology cluster: computer programming and network support. Presented in the introduction are program descriptions and suggested course…

  3. Mississippi Curriculum Framework for Machine Tool Operation/Machine Shop and Tool and Die Making Technology Cluster (Program CIP: 48.0507--Tool and Die Maker/Technologist) (Program CIP: 48.0503--Machine Shop Assistant). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the machine tool operation/machine tool and tool and die making technology programs cluster. Presented in the introductory section are a framework of courses and programs, description of the…

  4. Mississippi Curriculum Framework for Agricultural Business and Management Technology Cluster: Agricultural Business and Management Technology (CIP: 01.0302--Agricultural Animal Husbandry/Prod) (CIP: 01.0501--Agric Supplies Retail & Wholesale); Animal Husbandry Technology (CIP: 01.0302--Agricultural Animal Husbandry/Prod); Field Crops Technology (CIP: 01.0104--Farm & Ranch Management). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the agricultural business and management technology programs cluster. Presented in the introductory section are a framework of courses and concentrations, a description of the program, and…

  5. XVD Image Display Program

    NASA Technical Reports Server (NTRS)

    Deen, Robert G.; Andres, Paul M.; Mortensen, Helen B.; Parizher, Vadim; McAuley, Myche; Bartholomew, Paul

    2009-01-01

    The XVD [X-Windows VICAR (video image communication and retrieval) Display] computer program offers an interactive display of VICAR and PDS (planetary data systems) images. It is designed to efficiently display multiple-GB images and runs on Solaris, Linux, or Mac OS X systems using X-Windows.

  6. Mississippi Curriculum Framework for Medical Radiologic Technology (Radiography) (CIP: 51.0907--Medical Radiologic Technology). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the radiologic technology program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies for the program,…

  7. Mississippi Curriculum Framework for Postsecondary Health Information Technology (CIP: 51.0707--Medical Records Technol./Tech.). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the health information technology program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies, and…

  8. Mississippi Curriculum Framework for Diesel Equipment Technology (CIP: 47.0605--Diesel Engine Mechanic & Repairer). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the diesel equipment technology programs cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies,…

  9. DCIDE - Cancer Imaging Program

    Cancer.gov

    DCIDE is no longer taking applications, as of August 2009. Imaging drug development resources should be requested through the new NExT/CBC program which has its own application and review process. See NCI Experimental Therapeutics Program (NExT). There are 4 review dates per year, instead of the previous DCIDE submission and review process.

  10. 2002 Mississippi Curriculum Framework: Comprehensive Consumer & Homemaking Education (Program CIP: 20.0101 - Comprehensive Consumer & Homemaking Education). Family and Consumer Sciences (Program CIP: 20.0192 - Family and Consumer Sciences)

    ERIC Educational Resources Information Center

    Arthur, Jan; Blackwell, Michelle; Clemmer, Phyllis; Cocroft, Shunda; Everett, Laurelie; Green, Coretta; West, Brenda; Yarbrough, Ruthie

    2002-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  11. 2005 Mississippi Curriculum Framework: Secondary Welding Theory and Applications. (Program CIP: 48.0508 - Welding Technology/Welder)

    ERIC Educational Resources Information Center

    Cochran, Harry; Lawrence, Kenneth; Wages, Larry; Box, Dale; Johnston, Joe; Switzer, Ronald

    2005-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and instructors are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured…

  12. 2005 Mississippi Curriculum Framework: Secondary Machine Tool Operation. (Program CIP: 48.0503 - Machine Shop Technology/Assistant)

    ERIC Educational Resources Information Center

    Gorman, Nathan; Parker, Ronald; Lurie, Charles; Maples, Thomas

    2005-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  13. 2006 Mississippi Curriculum Framework: Secondary Culinary and Related Foods Technology. (Program CIP: 20.0401 - Institutional Food Workers & Admin)

    ERIC Educational Resources Information Center

    Durand, Linda; Early, Lanell; Wood, Becky Jolly

    2006-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  14. 2005 Mississippi Curriculum Framework: Secondary Horticulture. (Program CIP: 01.0601 - Applied Horticulture/Horticultural Operations, General)

    ERIC Educational Resources Information Center

    Research and Curriculum Unit, 2005

    2005-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  15. 2007 Mississippi Curriculum Framework: Secondary Food Products (Meats). (Program CIP: 01.0401 - Agricultural and Food Products Processing)

    ERIC Educational Resources Information Center

    Research and Curriculum Unit, 2007

    2007-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  16. 2005 Mississippi Curriculum Framework: Secondary General Drafting. (Program CIP: 15.1301 - Drafting and Design Technology/Technician, General)

    ERIC Educational Resources Information Center

    Kirk, Karen; Ladner, Daryl; Lewis, Carroll; Moran, Sheryl; Schneider, Chester; Strickland, Ruth Ann; Welch, Amanda

    2005-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  17. 2005 Mississippi Curriculum Framework: Secondary Hotel, Restaurant, and Tourism Management. (Program CIP: 52.0901--Hospitality Administration/Management)

    ERIC Educational Resources Information Center

    Bruce, Lady Anne; Chandler, Mark; Nichols, Raynette; Nevill, Becky

    2005-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  18. 2007 Mississippi Curriculum Framework: Secondary Custodian/Caretaker Services. (Program CIP: 19.0702 - Adult Development and Aging)

    ERIC Educational Resources Information Center

    Blake, LC; Harthcock, Sandra

    2007-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  19. 2006 Mississippi Curriculum Framework: Secondary Agricultural and Natural Resources Technology. (Program CIP: 01.0003 - Agricultural and Natural Resources)

    ERIC Educational Resources Information Center

    Bennett, Aaron; Chaney, David; Cole, Ted; Sumrall, Billy; White, Andy

    2006-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  20. 2006 Mississippi Curriculum Framework: Secondary Small Engine Repair. (Program CIP: 47.0606 - Small Engine Mechanic and Repairer)

    ERIC Educational Resources Information Center

    Evans, Jimmie; Britt, Steve; Smith, Toby; Jackson, Wade

    2006-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  1. 2007 Mississippi Curriculum Framework: Secondary Diesel Service Technology. (Program CIP: 47.0605 - Diesel Mechanics Technology/Technician)

    ERIC Educational Resources Information Center

    Ellison, Dave; Jackson, Edward

    2007-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  2. 2007 Mississippi Curriculum Framework: Secondary Agriculture Power and Machinery. (Program CIP: 01.0204 - Agricultural Power Machinery Operation)

    ERIC Educational Resources Information Center

    James, Lee; James, Terry; Washington, Lee; Taylor, John Grady; Rushing, Jimmy

    2007-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  3. 2007 Mississippi Curriculum Framework: Secondary Design Technology for Fashion and Interiors. (Program CIP: 19.0901 - Apparel and Textiles, General)

    ERIC Educational Resources Information Center

    Ingram, Carol; Lawrence, Angie; Pou, Margaret

    2007-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  4. 2008 Mississippi Curriculum Framework: Family and Consumer Sciences. (Program CIP: 19.9999 - Family and Consumer Sciences)

    ERIC Educational Resources Information Center

    Rosetti, Pamela; Byrd, Jenean; West, Brenda; Bigham, Melody

    2008-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  5. 2006 Mississippi Curriculum Framework: Secondary Outboard Marine Engine Mechanics. (Program CIP: 47.0692 - Outboard Engine Mechanics I)

    ERIC Educational Resources Information Center

    Chavarria, Ricardo; Bounds, Terry

    2006-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  6. Mississippi Curriculum Framework for Postsecondary Funeral Services Technology Programs (Program CIP: 12.0301--Funeral Service and Mortuary Science). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the state's funeral services technology program. Presented in the introduction are a program description and suggested course sequence. Section I lists baseline competencies for the funeral…

  7. "Children in Placement" (CIP): A Model for Citizen-Judicial Review.

    ERIC Educational Resources Information Center

    Wert, E. Sue; And Others

    1986-01-01

    Reports on the impact of the Children in Placement (CIP) program. CIP was found to expedite through the court the movement of children in foster care to more permanent placement. The program was used as an approach in an effort to better implement the 1980 Adoption Assistance and Child Welfare Act (P.L. 96-272). (BB)

  8. Image-Processing Program

    NASA Technical Reports Server (NTRS)

    Roth, D. J.; Hull, D. R.

    1994-01-01

    IMAGEP manipulates digital image data to effect various processing, analysis, and enhancement functions. It is keyboard-driven program organized into nine subroutines. Within subroutines are sub-subroutines also selected via keyboard. Algorithm has possible scientific, industrial, and biomedical applications in study of flows in materials, analysis of steels and ores, and pathology, respectively.

  9. Mississippi Curriculum Framework for Jewelry and Watch Repair Cluster (Program CIP: 47.0408--Watch, Clock, and Jewelry Repair). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the jewelry design, fabrication, and repair program. Presented in the introduction are a framework of programs and courses, a program description, and suggested course sequence. Section I…

  10. Mississippi Curriculum Framework for Business and Computer Data Processing (Program CIP: 52.1201--Mgmt. Info. Systems & Business Data). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for two secondary-level courses in business and computer data processing:…

  11. Mississippi Curriculum Framework for Business and Computer Technology (Program CIP: 52.0408--Gen. Office/Clerical & Typing Service). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for secondary-level courses in business and computer technology I-II.…

  12. Mississippi Curriculum Framework for Vehicle and Mobile Equipment Mechanics (Program CIP: 47.0699--Vehicle and Mobile Equipment Mech.). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for vehicle and mobile equipment mechanics I and II. Presented first are a…

  13. Computer Program Helps Enhance Images

    NASA Technical Reports Server (NTRS)

    Stanfill, Daniel F., IV

    1994-01-01

    Pixel Pusher is Macintosh application program for viewing and performing minor enhancements on imagery. Works with color images digitized to 8 bits. Reads image files in JPL's two primary image formats VICAR and PDS as well as in Macintosh PICT format. VICAR (NPO-18076) handles array of image-processing capabilities used for variety of applications, including processing of biomedical images, cartography, imaging of Earth resources, and geological exploration. Pixel Pusher also imports color lookup tables in VICAR format for viewing images in pseudocolor (256 colors). Written in Symantec's Think C.

  14. CIP1 polypeptides and their uses

    DOEpatents

    Foreman, Pamela; Van Solingen, Pieter; Goedegebuur, Frits; Ward, Michael

    2011-04-12

    Described herein are novel gene sequences isolated from Trichoderma reesei. Two genes encoding proteins comprising a cellulose binding domain, one encoding an arabionfuranosidase and one encoding an acetylxylanesterase are described. The sequences, CIP1 and CIP2, contain a cellulose binding domain. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.

  15. ICMICs - Cancer Imaging Program

    Cancer.gov

    ICMIC grants facilitate interaction among scientists from a variety of fields to conduct multidisciplinary research on cellular and molecular imaging related to cancer. Pre-ICMIC planning grants have provided time and funds for investigators and institutions to prepare themselves, organizationally and scientifically, to establish ICMICs.

  16. Evaluation Manual for CIP Courses: Objectives and Implementation Procedures.

    ERIC Educational Resources Information Center

    Siri, Carmen

    This manual has been designed to guide courses on potato production sponsored by the International Potato Center (CIP) in Lima (Peru). It describes the CIP Course Evaluation System that is presently used and provides guidelines on how to use feedback more effectively for improving training. CIP evaluations are largely formative. The CIP focuses on…

  17. Infrared imaging spectroradiometer program overview

    NASA Astrophysics Data System (ADS)

    Rapp, Ronald J.; Register, Henry I.

    1995-06-01

    The Department of Defense, through the US Air Force's Wright Laboratory, Armament Directorate is sponsoring the development of two types of IR imaging spectroradiometers (project name: IRIS) to measure the spatial/spectral characteristics of various military targets. Design and analysis of several technical approaches were conducted during an initial phase of the program. The technical approaches investigated included: a dispersive imaging spectrometer design utilizing a fiber-optic reformatter (contractor: ERIM); an imaging acousto-optic tunable filter (AOTF) design (contractor: Westinghouse); a spatial/spectral Fourier transform infrared (FTIR) spectrometer (contractor: Bomem Inc./Canada); a spatially modulated imaging fourier transform spectrometer (contractor: Daedalus Enterprises); an imaging Fabry-Perot design (contractor: Physical Sciences Inc.). Two of these designs were selected for brass board prototype fabrication. An FTIR prototype being built by Bomem Inc., offers an instrument with high sensitivity and high spectral resolution with modest spatial performance. An imaging Fabry-Perot prototype being built by Physical Sciences Inc., offers high spatial resolution with moderate sensitivity and spectral resolution.

  18. 2005 Mississippi Curriculum Framework: Secondary Heating and Air Conditioning. (Program CIP: 47.0201 - Heating, Air Conditioning, Ventilation, and Refrigeration Maintenance Technology/Technician)

    ERIC Educational Resources Information Center

    Green, Jacob; LeBatard, Ernest; Wiggington, Donnie; Williams, Bennett

    2005-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  19. Mississippi Curriculum Framework for Family and Consumer Sciences and Related Technology (Enrichment) (CIP: 20.0101--Comprehensive Consumer & Homemkg. Ed.). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for family and consumer sciences and related technology (enrichment).…

  20. 2005 Mississippi Curriculum Framework: Secondary Vehicle and Mobile Equipment Technician. (Program CIP: 47.0699 - Vehicle Maintenance and Repair Technology, Other)

    ERIC Educational Resources Information Center

    Brackeen, Scott; Freeman, Roscoe; Tiblier, Chris; Batton, James; Ealy, Houston; Simmons, Gerald

    2005-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  1. 2007 Mississippi Curriculum Framework: Secondary Automotive Collision Repair Technology. (Program CIP: 47.0603 - Autobody/Collision and Repair Technology/Technician)

    ERIC Educational Resources Information Center

    Dowds, Eris; Anderson, Daniel; Sizemore, Rick; Johnson, John

    2007-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  2. DIFMAP: an interactive program for synthesis imaging.

    NASA Astrophysics Data System (ADS)

    Shepherd, M. C.; Pearson, T. J.; Taylor, G. B.

    1994-05-01

    DIFMAP is a new interactive program for synthesis imaging. It includes data display, data editing, selfcalibration, imaging, and deconvolution. The program, written in ANSI C, runs on UNIX workstations.

  3. Complete Genome Sequence of Rahnella aquatilis CIP 78.65

    PubMed Central

    Bruce, David; Detter, Chris; Goodwin, Lynne A.; Han, James; Han, Cliff S.; Held, Brittany; Land, Miriam L.; Mikhailova, Natalia; Nolan, Matt; Pennacchio, Len; Pitluck, Sam; Tapia, Roxanne; Woyke, Tanja; Sobecky, Patricia A.

    2012-01-01

    Rahnella aquatilis CIP 78.65 is a gammaproteobacterium isolated from a drinking water source in Lille, France. Here we report the complete genome sequence of Rahnella aquatilis CIP 78.65, the type strain of R. aquatilis. PMID:22582378

  4. Complete Genome Sequence of Rahnella aquatilis CIP 78.65

    SciTech Connect

    Martinez, Robert J; Bruce, David; Detter, J C; Goodwin, Lynne A.; Han, James; Han, Cliff; Held, Brittany; Land, Miriam L; Mikhailova, Natalia; Nolan, Matt; Pennacchio, Len; Pitluck, Sam; Tapia, Roxanne; Woyke, Tanja; Sobeckya, Patricia A.

    2012-01-01

    Rahnella aquatilis CIP 78.65 is a gammaproteobacterium isolated from a drinking water source in Lille, France. Here we report the complete genome sequence of Rahnella aquatilis CIP 78.65, the type strain of R. aquatilis.

  5. Cancer Imaging

    MedlinePlus

    ... I/II Trials CIP ARRA-Funded Clinical Trials Informatics The Cancer Imaging Archive TCGA Imaging Genomics Quantitative Imaging Network LIDC-IDRI Imaging Informatics Resources News & Events News and Announcements Events – Meetings ...

  6. Career Information Partnership. CIP Status Report.

    ERIC Educational Resources Information Center

    Welton Beauchamp Professional Centre, Ottawa (Ontario).

    Employment and Immigration Canada explored, with potential partners, the feasibility of establishing a Canadian Career Information Partnership (CIP) network. A series of exploratory meetings was scheduled across Canada to determine: (1) gaps in information needed by youth and adults for effective career exploration, planning, and decision making;…

  7. Expanding Career Awareness with CIPS.

    ERIC Educational Resources Information Center

    Patterson, John

    Career Information Packets is an individually oriented career exploration program developed for high school students. The program goals are to: (1) assist students in becoming aware of their patterns, of values, interests and aptitudes in relation to the world of work; (2) to assist students in making tentative career choices; and (3) assist them…

  8. NASA/JPL's Imaging Radar Outreach Program

    NASA Technical Reports Server (NTRS)

    Freeman, A.; O'Leary, E.; Chapman, B.; Trimble, J.

    1996-01-01

    In order to build a user community for future NASA imaging radar products and programs, outreach activities have been implemented by JPL. These include: education outreach, public awareness outreach, and outreach to areas of the scientific and applications community who are not traditional imaging radar users. A key component is the NASA/JPL Imaging Radar Home Page on the World Wide Web.

  9. General-Purpose Image-Data Program

    NASA Technical Reports Server (NTRS)

    Engle, Steven W.

    1988-01-01

    Image Database computer program, IBASE, is general-purpose imagery-information system. Use accomplished either by commands or through hierarchy of menus. Analytical capabilities of IBASE include contigency tables, image filtering (low-, high-, and band-pass), proximity maps, clustering, histograms, regression, slope calculations, scaling, and Boolean manipulations. Also has interface to Cheshire Image Classification expert system. Written in FORTRAN 77.

  10. The MER/CIP Portal for Ground Operations

    NASA Technical Reports Server (NTRS)

    Chan, Louise; Desai, Sanjay; DOrtenzio, Matthew; Filman, Robtert E.; Heher, Dennis M.; Hubbard, Kim; Johan, Sandra; Keely, Leslie; Magapu, Vish; Mak, Ronald

    2003-01-01

    We developed the Mars Exploration Rover/Collaborative Information Portal (MER/CIP) to facilitate MER operations. MER/CIP provides a centralized, one-stop delivery platform integrating science and engineering data from several distributed heterogeneous data sources. Key issues for MER/CIP include: 1) Scheduling and schedule reminders; 2) Tracking the status of daily predicted outputs; 3) Finding and analyzing data products; 4) Collaboration; 5) Announcements; 6) Personalization.

  11. A comparison of current prediction imaging programs.

    PubMed

    Smith, J Dempsey; Thomas, Paul M; Proffit, William R

    2004-05-01

    To investigate perceived differences in the ability of current software to simulate the actual outcome of orthognathic surgery, we chose 10 difficult test cases with vertical discrepancies and "retreated" them using the actual surgical changes. Five programs--Dentofacial Planner Plus, Dolphin Imaging, Orthoplan, Quick Ceph Image, and Vistadent--were evaluated, by using both the default result and a refined result created with each program's enhancement tools. Three panels (orthodontists, oral-maxillofacial surgeons, and laypersons) judged the default images and the retouched simulations by ranking the simulations in side-by-side comparisons and by rating each simulation relative to the actual outcome on a 6-point scale. For the default and retouched images, Dentofacial Planner Plus was judged the best default simulation 79% and 59% of the time, respectively, and its default images received the best (lowest) mean score (2.46) on the 6-point scale. It also scored best (2.26) when the retouched images were compared, but the scores for Dolphin Imaging (2.83) and Quick Ceph (3.03) improved. Retouching had little impact on the scores for the other programs. Although the results show differences in simulation ability, selecting a software package depends on many factors. Performance and ease of use, cost, compatibility, and other features such as image and practice management tools are all important considerations. Users concerned with operating system compatibility and practice management integration might want to consider Dolphin Imaging and Quick Ceph, the programs comprising the second tier. PMID:15127020

  12. Breadboard linear array scan imager program

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The performance was evaluated of large scale integration photodiode arrays in a linear array scan imaging system breadboard for application to multispectral remote sensing of the earth's resources. Objectives, approach, implementation, and test results of the program are presented.

  13. GPU programming for biomedical imaging

    NASA Astrophysics Data System (ADS)

    Caucci, Luca; Furenlid, Lars R.

    2015-08-01

    Scientific computing is rapidly advancing due to the introduction of powerful new computing hardware, such as graphics processing units (GPUs). Affordable thanks to mass production, GPU processors enable the transition to efficient parallel computing by bringing the performance of a supercomputer to a workstation. We elaborate on some of the capabilities and benefits that GPU technology offers to the field of biomedical imaging. As practical examples, we consider a GPU algorithm for the estimation of position of interaction from photomultiplier (PMT) tube data, as well as a GPU implementation of the MLEM algorithm for iterative image reconstruction.

  14. ICMIC Institutions - Cancer Imaging Program

    Cancer.gov

    ICMIC grants facilitate interaction among scientists from a variety of fields to conduct multidisciplinary research on cellular and molecular imaging related to cancer. Pre-ICMIC planning grants have provided time and funds for investigators and institutions to prepare themselves, organizationally and scientifically, to establish ICMICs.

  15. IND Regulatory & Manufacturing Resources - Cancer Imaging Program

    Cancer.gov

    The Cancer Imaging Program has been creating Investigational New Drug Applications (IND) for imaging agents in order to engage in multi-center clinical trials of these materials. A subset of the documents filed is being made available to the research community to implement routine synthesis of tracers at their own facilities and to assist investigators with the filing of their own INDs. The first of these document sets is for F-18 fluorothymidine (FLT).

  16. A comparison of current prediction imaging programs

    PubMed Central

    Smith, J. Dempsey; Thomas, Paul M.; Proffit, William R.

    2013-01-01

    To investigate perceived differences in the ability of current software to simulate the actual outcome of orthognathic surgery, we chose 10 difficult test cases with vertical discrepancies and “retreated” them using the actual surgical changes. Five programs—Dentofacial Planner Plus, Dolphin Imaging, Orthoplan, Quick Ceph Image, and Vistadent—were evaluated, by using both the default result and a refined result created with each program’s enhancement tools. Three panels (orthodontists, oral-maxillofacial surgeons, and laypersons) judged the default images and the retouched simulations by ranking the simulations in side-by-side comparisons and by rating each simulation relative to the actual outcome on a 6-point scale. For the default and retouched images, Dentofacial Planner Plus was judged the best default simulation 79% and 59% of the time, respectively, and its default images received the best (lowest) mean score (2.46) on the 6-point scale. It also scored best (2.26) when the retouched images were compared, but the scores for Dolphin Imaging (2.83) and Quick Ceph (3.03) improved. Retouching had little impact on the scores for the other programs. Although the results show differences in simulation ability, selecting a software package depends on many factors. Performance and ease of use, cost, compatibility, and other features such as image and practice management tools are all important considerations. Users concerned with operating system compatibility and practice management integration might want to consider Dolphin Imaging and Quick Ceph, the programs comprising the second tier. PMID:15127020

  17. Cyclin kinase inhibitor p21WAF1/CIP1 in malignant melanoma: reduced expression in metastatic lesions.

    PubMed Central

    Maelandsmo, G. M.; Holm, R.; Fodstad, O.; Kerbel, R. S.; Flørenes, V. A.

    1996-01-01

    Immunohistochemical analysis of the expression of the cyclin kinase inhibitor p21WAF1/CIP1 in a panel of primary and metastatic human melanocytic tumors was performed. It was found that, independent of the p53 status, approximately 30% of the primary melanomas and 40% of the metastases completely lacked expression of this cell cycle inhibitor. Some tumors were also analyzed by Northern blotting, and in most of the cases a consistant correlation between mRNA and protein expression was observed. In four benign nevi studied, WAF1/CIP1 mRNA was expressed whereas the protein was not detected, suggesting a post-transcriptional regulation of the inhibitor in these cases. In superficial spreading melanomas, a significant correlation between protein expression and tumor thickness was found, with thin lesions showing low protein levels. Interestingly, by comparing primary and metastatic specimens obtained from the same patient, a reduction in p21WAF1/CIP1 antibody staining was observed in the latter, probably reflecting a more aggressive phenotype of the metastases. In conclusion, our results demonstrate the complexity in the relationship between p21WAF1/CIP1 expression and tumor phenotype and furthermore suggest that aberrant expression of the cyclin-dependent kinase inhibitor may be of importance in the development and progression of sporadic malignant melanoma. Images Figure 1 Figure 2 PMID:8952518

  18. Advanced imaging systems programs at DARPA MTO

    NASA Astrophysics Data System (ADS)

    Dhar, Nibir K.; Elizondo, Lee A.; Dat, Ravi; Elizondo, Shelly L.

    2013-09-01

    In this paper, we review a few selected imaging technology development programs at the Defense Advanced Research Projects Agency (DARPA) in the reflective visible to the emissive/thermal long wave infrared (LWIR) spectral bands. For the reflective visible band, results are shown for two different imagers: a gigapixel monocentric multi-scale camera design that solves the scaling issues for a high pixel count, and a wide field of view and a single photon detection camera with a large dynamic range. Also, a camera with broadband capability covering both reflective and thermal bands (0.5 μm to 5.0 μm) with >80% quantum efficiency is discussed. In the emissive/thermal band, data is presented for both uncooled and cryogenically cooled LWIR detectors with pixel pitches approaching the fundamental detection limits. By developing wafer scale manufacturing processes and reducing the pixel size of uncooled thermal imagers, it is shown that an affordable camera on a chip, capable of seeing through obscurants in day or night, is feasible. Also, the fabrication and initial performance of the world's first 5 μm pixel pitch LWIR camera is discussed. Lastly, we use an initial model to evaluate the signal to noise ratio and noise equivalent differential temperature as a function of well capacity to predict the performance for this thermal imager.

  19. AMOEBA clustering revisited. [cluster analysis, classification, and image display program

    NASA Technical Reports Server (NTRS)

    Bryant, Jack

    1990-01-01

    A description of the clustering, classification, and image display program AMOEBA is presented. Using a difficult high resolution aircraft-acquired MSS image, the steps the program takes in forming clusters are traced. A number of new features are described here for the first time. Usage of the program is discussed. The theoretical foundation (the underlying mathematical model) is briefly presented. The program can handle images of any size and dimensionality.

  20. FY 2013 Educational Facilities Master Plan and the FY 2013-2018 Capital Improvements Program

    ERIC Educational Resources Information Center

    Montgomery County Public Schools, 2012

    2012-01-01

    The FY 2013 Educational Facilities Master Plan (Master Plan) and the FY 2013-2018 Capital Improvements Program (CIP) reflect the adopted actions of the Montgomery County (Maryland) Council and integrate the facilities planning process with the annual capital budget and the six-year CIP. The CIP is developed in accordance with the Board of…

  1. FY 2011 Educational Facilities Master Plan & the FY 2011-2016 Capital Improvements Program

    ERIC Educational Resources Information Center

    Montgomery County Public Schools, 2010

    2010-01-01

    The FY 2011 Educational Facilities Master Plan (Master Plan) and FY 2011-2016 Capital Improvements Program (CIP) reflect the adopted actions of the Montgomery County (Maryland) Council and integrate the facilities planning process with the annual capital budget and the six-year CIP. The CIP is developed in accordance with the Board of Education…

  2. FY 2012 Educational Facilities Master Plan and the Amended FY 2011-2016 Capital Improvements Program

    ERIC Educational Resources Information Center

    Montgomery County Public Schools, 2011

    2011-01-01

    The FY 2012 Educational Facilities Master Plan (Master Plan) and Amendments to the FY 2011-2016 Capital Improvements Program (CIP) reflect the adopted actions of the Montgomery County (Maryland) Council and integrate the facilities planning process with the annual capital budget and the six-year CIP. The CIP is developed in accordance with the…

  3. FY 2007 Educational Facilities Master Plan and the FY 2007-2012 Capital Improvements Program

    ERIC Educational Resources Information Center

    Montgomery County Public Schools, 2006

    2006-01-01

    The FY 2007 Educational Facilities Master Plan (Master Plan) and FY 2007-2012 Capital Improvements Program (CIP) reflect the adopted actions of the Montgomery County (Maryland) Council and integrate the facilities planning process with the annual capital budget and the six-year CIP. The CIP is developed in accordance with the Board of Education…

  4. Formation of high electrical-resistivity thin surface layer on carbonyl-iron powder (CIP) and thermal stability of nanocrystalline structure and vortex magnetic structure of CIP

    NASA Astrophysics Data System (ADS)

    Sugimura, K.; Miyajima, Y.; Sonehara, M.; Sato, T.; Hayashi, F.; Zettsu, N.; Teshima, K.; Mizusaki, H.

    2016-05-01

    This study focuses on the carbonyl-iron powder (CIP) used in the metal composite bulk magnetic core for high-efficient/light-weight SiC/GaN power device MHz switching dc-dc converter, where the fine CIP with a mean diameter of 1.1 μm is used to suppress the MHz band eddy current inside the CIP body. When applying the CIP to composite core together with the resin matrix, high electrical resistivity layer must be formed on the CIP-surface in order to suppress the overlapped eddy current between adjacent CIPs. In this study, tens nm thick silica (SiO2) was successfully deposited on the CIP-surface by using hydrolysis of TEOS (Si(OC2H5)4). Also tens nm thick oxidized layer of the CIP-surface was successfully formed by using CIP annealing in dry air. The SiC/GaN power device can operate at ambient temperature over 200 degree-C, and the composite magnetic core is required to operate at such ambient temperature. The as-made CIP had small coercivity below 800 A/m (10 Oe) due to its nanocrystalline-structure and had a single vortex magnetic structure. From the experimental results, both nanocrystalline and single vortex magnetic structure were maintained after heat-exposure of 250 degree-C, and the powder coercivity after same heat-exposure was nearly same as that of the as-made CIP. Therefore, the CIP with thermally stable nanocrystalline-structure and vortex magnetic state was considered to be heat-resistant magnetic powder used in the iron-based composite core for SiC/GaN power electronics.

  5. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection

    PubMed Central

    Cvrljevic, Anna; Khan, Mohd Moin; Treise, Irina; Adler, Thure; Aguilar-Pimentel, Juan Antonio; Au-Yeung, Byron; Sittig, Eleonora; Laajala, Teemu Daniel; Chen, Yiling; Oeder, Sebastian; Calzada-Wack, Julia; Horsch, Marion; Aittokallio, Tero; Busch, Dirk H.; Ollert, Markus W.; Neff, Frauke; Beckers, Johannes; Gailus-Durner, Valerie; Fuchs, Helmut; de Angelis, Martin Hrabě; Chen, Zhi; Lahesmaa, Riitta; Westermarck, Jukka

    2016-01-01

    The oncoprotein Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) is overexpressed in most malignancies and is an obvious candidate target protein for future cancer therapies. However, the physiological importance of CIP2A-mediated PP2A inhibition is largely unknown. As PP2A regulates immune responses, we investigated the role of CIP2A in normal immune system development and during immune response in vivo. We show that CIP2A-deficient mice (CIP2AHOZ) present a normal immune system development and function in unchallenged conditions. However when challenged with Listeria monocytogenes, CIP2AHOZ mice display an impaired adaptive immune response that is combined with decreased frequency of both CD4+ T-cells and CD8+ effector T-cells. Importantly, the cell autonomous effect of CIP2A deficiency for T-cell activation was confirmed. Induction of CIP2A expression during T-cell activation was dependent on Zap70 activity. Thus, we reveal CIP2A as a hitherto unrecognized mediator of T-cell activation during adaptive immune response. These results also reveal CIP2AHOZ as a possible novel mouse model for studying the role of PP2A activity in immune regulation. On the other hand, the results also indicate that CIP2A targeting cancer therapies would not cause serious immunological side-effects. PMID:27100879

  6. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection.

    PubMed

    Côme, Christophe; Cvrljevic, Anna; Khan, Mohd Moin; Treise, Irina; Adler, Thure; Aguilar-Pimentel, Juan Antonio; Au-Yeung, Byron; Sittig, Eleonora; Laajala, Teemu Daniel; Chen, Yiling; Oeder, Sebastian; Calzada-Wack, Julia; Horsch, Marion; Aittokallio, Tero; Busch, Dirk H; Ollert, Markus W; Neff, Frauke; Beckers, Johannes; Gailus-Durner, Valerie; Fuchs, Helmut; Hrabě de Angelis, Martin; Chen, Zhi; Lahesmaa, Riitta; Westermarck, Jukka

    2016-01-01

    The oncoprotein Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) is overexpressed in most malignancies and is an obvious candidate target protein for future cancer therapies. However, the physiological importance of CIP2A-mediated PP2A inhibition is largely unknown. As PP2A regulates immune responses, we investigated the role of CIP2A in normal immune system development and during immune response in vivo. We show that CIP2A-deficient mice (CIP2AHOZ) present a normal immune system development and function in unchallenged conditions. However when challenged with Listeria monocytogenes, CIP2AHOZ mice display an impaired adaptive immune response that is combined with decreased frequency of both CD4+ T-cells and CD8+ effector T-cells. Importantly, the cell autonomous effect of CIP2A deficiency for T-cell activation was confirmed. Induction of CIP2A expression during T-cell activation was dependent on Zap70 activity. Thus, we reveal CIP2A as a hitherto unrecognized mediator of T-cell activation during adaptive immune response. These results also reveal CIP2AHOZ as a possible novel mouse model for studying the role of PP2A activity in immune regulation. On the other hand, the results also indicate that CIP2A targeting cancer therapies would not cause serious immunological side-effects. PMID:27100879

  7. Development of mice without Cip/Kip CDK inhibitors

    SciTech Connect

    Tateishi, Yuki; Matsumoto, Akinobu; Kanie, Tomoharu; Hara, Eiji; Nakayama, Keiko; Nakayama, Keiichi I.

    2012-10-19

    Highlights: Black-Right-Pointing-Pointer Mice lacking Cip/Kip CKIs (p21, p27, and p57) survive until embryonic day 13.5. Black-Right-Pointing-Pointer Proliferation of MEFs lacking all three Cip/Kip CKIs appears unexpectedly normal. Black-Right-Pointing-Pointer CDK2 kinase activity of the triple mutant MEFs is increased in G0 phase. -- Abstract: Timely exit of cells from the cell cycle is essential for proper cell differentiation during embryogenesis. Cyclin-dependent kinase (CDK) inhibitors (CKIs) of the Cip/Kip family (p21, p27, and p57) are negative regulators of cell cycle progression and are thought to be essential for development. However, the extent of functional redundancy among Cip/Kip family members has remained largely unknown. We have now generated mice that lack all three Cip/Kip CKIs (TKO mice) and compared them with those lacking each possible pair of these proteins (DKO mice). We found that the TKO embryos develop normally until midgestation but die around embryonic day (E) 13.5, slightly earlier than p27/p57 DKO embryos. The TKO embryos manifested morphological abnormalities as well as increased rates of cell proliferation and apoptosis in the placenta and lens that were essentially indistinguishable from those of p27/p57 DKO mice. Unexpectedly, the proliferation rate and cell cycle profile of mouse embryonic fibroblasts (MEFs) lacking all three Cip/Kip CKIs did not differ substantially from those of control MEFs. The abundance and kinase activity of CDK2 were markedly increased, whereas CDK4 activity and cyclin D1 abundance were decreased, in both p27/p57 DKO and TKO MEFs during progression from G{sub 0} to S phase compared with those in control MEFs. The extents of the increase in CDK2 activity and the decrease in CDK4 activity and cyclin D1 abundance were greater in TKO MEFs than in p27/p57 DKO MEFs. These results suggest that p27 and p57 play an essential role in mouse development after midgestation, and that p21 plays only an auxiliary role in

  8. Radiology Network (ACRIN) - Cancer Imaging Program

    Cancer.gov

    ACRIN is funded to improve the quality and utility of imaging in cancer research and cancer care through expert, multi-institutional clinical evaluation of discoveries and technological innovations relevant to imaging science as applied in clinical oncology.

  9. Cellular localization of CIP2A determines its prognostic impact in superficial spreading and nodular melanoma.

    PubMed

    Flørenes, Vivi Ann; Emilsen, Elisabeth; Dong, Hiep Phuc; Førsund, Mette; Holm, Ruth; Slipicevic, Ana

    2015-06-01

    Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an important oncogene contributing to cancer progression partially by regulating cMYC and AKT. We examined CIP2A expression in cutaneous melanomas, its association with clinicopathological parameters and mapped molecular mechanisms regulated by CIP2A in vitro. CIP2A expression was analyzed by immunohistochemistry in 17 nevi, 132 primary melanomas and 49 metastases. Effects of siRNA-mediated down-regulation on proliferation, apoptosis and signaling pathways were assessed in melanoma cell lines. In superficial spreading melanomas (SSM), high nuclear CIP2A expression was associated with poor overall survival (OS) (P = 0.0018). Surprisingly, high cytoplasmic expression was related to improved relapse-free (P = 0.031) and OS (P = 0.014) in nodular melanomas (NM). In vitro experiments revealed that CIP2A can regulate proliferation and/or apoptosis partially through the PI3K/AKT pathway but also independently. In summary, CIP2A could represent a potential therapeutic target in SSM. However, in NM cytoplasmic CIP2A is associated with improved prognosis indicating that CIP2A has distinct, complex functions dependent on the molecular context and histological subtype. As seen in other cancer types, CIP2A can influence cMYC and AKT, but our data also suggest that in melanoma it has additional targets which need to be identified. PMID:25663244

  10. The anchorage function of CipA (CelL), a scaffolding protein of the Clostridium thermocellum cellulosome.

    PubMed Central

    Kruus, K; Lua, A C; Demain, A L; Wu, J H

    1995-01-01

    Enzymatic cellulose degradation is a heterogeneous reaction requiring binding of soluble cellulase molecules to the solid substrate. Based on our studies of the cellulase complex of Clostridium thermocellum (the cellulosome), we have previously proposed that such binding can be brought about by a special "anchorage subunit." In this "anchor-enzyme" model, CipA (a major subunit of the cellulosome) enhances the activity of CelS (the most abundant catalytic subunit of the cellulosome) by anchoring it to the cellulose surface. We have subsequently reported that CelS contains a conserved duplicated sequence at its C terminus and that CipA contains nine repeated sequences with a cellulose binding domain (CBD) in between the second and third repeats. In this work, we reexamined the anchor-enzyme mechanism by using recombinant CelS (rCelS) and various CipA domains, CBD, R3 (the repeat next to CBD), and CBD/R3, expressed in Escherichia coli. As analyzed by non-denaturing gel electrophoresis, rCelS, through its conserved duplicated sequence, formed a stable complex with R3 or CBD/R3 but not with CBD. Although R3 or CBD alone did not affect the binding of rCelS to cellulose, such binding was dependent on CBD/R3, indicating the anchorage role of CBD/R3. Such anchorage apparently increased the rCelS activity toward crystalline cellulose. These results substantiate the proposed anchor-enzyme model and the expected roles of individual CipA domains and the conserved duplicated sequence of CelS. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 PMID:7568112

  11. Human Genome Program Image Gallery (from genomics.energy.gov)

    DOE Data Explorer

    This collection contains approximately 240 images from the genome programs of DOE's Office of Science. The images are divided into galleries related to biofuels research, systems biology, and basic genomics. Each image has a title, a basic citation, and a credit or source. Most of the images are original graphics created by the Genome Management Information System (GMIS). GMIS images are recognizable by their credit line. Permission to use these graphics is not needed, but please credit the U.S. Department of Energy Genome Programs and provide the website http://genomics.energy.gov. Other images were provided by third parties and not created by the U.S. Department of Energy. Users must contact the person listed in the credit line before using those images. The high-resolution images can be downloaded.

  12. Laboratory evaluation of the CIP 10 personal dust sampler.

    PubMed

    Gero, A; Tomb, T

    1988-06-01

    The "capteur individuel de poussiere" CIP 10 personal dust sampler--developed by the Centre d'Etudes et Recherches de Charbonnages de France (CERCHAR) research organization--is a small, quiet, lightweight unit which samples at a flow rate of 10 L/min. It is a three-stage sampler, using two stages to remove nonrespirable dust particles and one stage to collect the respirable fraction. Airflow through the sampler is induced by the third stage, which is a rotating collector cup that contains a fine grade sponge. Laboratory tests were conducted in a dust chamber using aerosols of Arizona road dust, coal dust and silica dust. Aerosol concentrations measured with the CIP 10 were compared to those measured with the coal mine dust personal sampler unit used in the United States. The results of this study showed that aerosol concentrations measured with the CIP 10 were linearly related to those obtained with the coal mine dust personal sampler. The relationship, however, was dependent on preselector configuration and aerosol characteristics. The collection medium allows some small particles (less than 3 microns) to pass through the sampler without being collected. As much as 13% (by weight) of the aerosol that penetrated through the preseparating stages was exhausted from the sampler. PMID:2840817

  13. Examining the Perceptions of Brand Images Regarding Competing MBA Programs

    ERIC Educational Resources Information Center

    Hinds, Timothee; Falgoust, Dexter; Thomas, Kerry, Jr.; Budden, Michael C.

    2010-01-01

    In today's economic environment, it is crucial to create a strong, consistent brand image within a graduate business program. This study examines the perceptions that students at Southeastern Louisiana University hold about its MBA program and the MBA programs of its main competitors. A focus group was conducted to identify competitors and factors…

  14. A Macintosh and Windows program for assessing body-image disturbance using adjustable image distortion.

    PubMed

    Shibata, Seiji

    2002-02-01

    Body image is one of the most important concepts in the study of eating disorders. The assessment and treatment of body-image issues are considered to be integral aspects of assessment and clinical management of eating disorders (Thompson, 1996b). The program, BodyImage, is software for the assessment of body-image disturbance. It uses an image-distorting technique to estimate body size. The image of the whole body or parts of the body can be captured as a digital image by a digital camera. Response data from participants are recorded as ASCII files so that other computer programs such as spreadsheets or word processing programs can handle the data. BodyImage works on personal computers, both Macintosh and Windows. It is available at no cost, and it can be obtained from the following URL: http://homepage2.nifty.com/s_shibata/softwares/bodyimage.html. PMID:12060995

  15. MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation.

    PubMed

    Jin, Yetao; Lee, Hunjoo; Zeng, Shelya X; Dai, Mu-Shui; Lu, Hua

    2003-12-01

    The CDK inhibitor p21waf1/cip1 is degraded by a ubiquitin-independent proteolytic pathway. Here, we show that MDM2 mediates this degradation process. Overexpression of wild-type or ring finger-deleted, but not nuclear localization signal (NLS)-deleted, MDM2 decreased p21waf1/cip1 levels without ubiquitylating this protein and affecting its mRNA level in p53(-/-) cells. This decrease was reversed by the proteasome inhibitors MG132 and lactacystin, by p19(arf), and by small interfering RNA (siRNA) against MDM2. p21waf1/cip1 bound to MDM2 in vitro and in cells. The p21waf1/cip1-binding-defective mutant of MDM2 was unable to degrade p21waf1/cip1. MDM2 shortened the half-life of both exogenous and endogenous p21waf1/cip1 by 50% and led to the degradation of its lysine-free mutant. Consequently, MDM2 suppressed p21waf1/cip1-induced cell growth arrest of human p53(-/-) and p53(-/-)/Rb(-/-)cells. These results demonstrate that MDM2 directly inhibits p21waf1/cip1 function by reducing p21waf1/cip1 stability in a ubiquitin-independent fashion. PMID:14633995

  16. CIP2A down regulation enhances the sensitivity of pancreatic cancer cells to gemcitabine

    PubMed Central

    He, Jin; Zhao, Long; Wang, Xiaodong; Li, Zhennan; Qian, Jianjun

    2016-01-01

    Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein which participates in inhibiting tumor apoptosis in pancreatic cancer cells. Using immunohistochemical staining, we investigated the expression of CIP2A protein in 72 cases of human pancreatic ductal adenocarcinoma (PDAC) tissue and 27 cases of adjacent normal pancreatic tissue. The positive rate of CIP2A protein expression in pancreatic cancer tissue was70.83 %, which was significantly higher than that in adjacent non- cancerous pancreatic tissue (11.11%). The expression of CIP2A was found to be correlated with TNM stage, but not correlated with age, gender, tumor location, smoking status, alcohol consumption, diabetes, high blood pressure, BMI, tumor size, lymph node metastasis or distant metastases. Kaplan- Meier survival analysis showed that patients with positive CIP2A protein expression had a lower overall survival rate than patients without CIP2A expression. COX regression analysis indicated that expression of CIP2A was an independent prognostic factor for pancreatic ductal adenocarcinoma. In addition, down-regulation of CIP2A inhibited cell proliferation and increased sensitivity to gemcitabine in pancreatic cancer cells by decreasing AKT signaling pathway. Our results indicated that down-regulation of CIP2A could be a novel therapeutic strategy for pancreatic cancer. PMID:26894380

  17. MYC accelerates p21CIP-induced megakaryocytic differentiation involving early mitosis arrest in leukemia cells.

    PubMed

    Muñoz-Alonso, María J; Ceballos, Laura; Bretones, Gabriel; Frade, Pilar; León, Javier; Gandarillas, Alberto

    2012-05-01

    p21(CIP) is a potent cell cycle inhibitor often up-regulated in differentiation. Protooncogene MYC induces cell growth and proliferation, inhibits differentiation and represses p21(CIP). However, both molecules are involved in processes of polyploidisation, cell size increase, differentiation and senescence. It is unclear why MYC has a dual role in differentiation. We have previously shown that overexpression of p21(CIP) in K562 myeloid cells induces megakaryocytic differentiation with polyploidy. We have now investigated the requirements for p21(CIP) to block mitosis and induce differentiation in the presence of overactivated MYC. Silencing and over-expression studies showed that p21(CIP) is required to induce differentiation. However, the expression of p21(CIP) needs to be transient to irreversibly inhibit mitosis but not DNA replication, what leads to polyploidy. Transient overexpression of p21(CIP) caused early down-regulation of mitotic Cyclins and up-regulation of G1/S Cyclins D and E, changes typical of endoreplication. Interestingly, over-activation of MYC did not release the proliferative block imposed by p21(CIP) and instead, accelerated cell size increase, megakaryocytic differentiation and polyploidisation. Our data suggests that in some systems p21(CIP) takes part in a mitosis control driving MYC-induced cellular growth into differentiation. PMID:21769863

  18. Ultrasound Research Interface - Cancer Imaging Program

    Cancer.gov

    The ultrasound research interface permits extensive instrument parameter control of a commercially available scanner that allows access to, and export of, the beam-formed signal data while simultaneously displaying the ultrasound system-processed data as a clinical image.

  19. Program For Thresholding In Digital Images

    NASA Technical Reports Server (NTRS)

    Nolf, Scott R.; Avis, Elizabeth L.; Matthews, Christine G.; Stacy, Kathryn

    1994-01-01

    THRTOOL program applies thresholding techniques to Sun rasterfiles. Provides for choice among four methods of thresholding. Written in C language and implemented on Sun series and Silicon Graphics IRIS machines.

  20. Program Generates Images Of Solid Surfaces

    NASA Technical Reports Server (NTRS)

    Goza, Sharon P.; Bell, Bradley; Shores, David

    1991-01-01

    Solid Surface Modeler (SSM) computer program generates three-dimensional computer models of solid surfaces for use in visual analysis and animation. Provides advanced functions, including Constructive Solid Geometry, Skin Construction, Tube Construction, Material Property Editing, and Texture Map Tools. Allows user to change such attributes as color, reflectivity, smoothing, and position of object easily. Model saved in ASCII or binary format for use in another program or saved in edit format for reloading in SSM. Written in standard C.

  1. CIP2A expression and prognostic role in patients with esophageal adenocarcinoma.

    PubMed

    Rantanen, Tuomo; Kauttu, Tuuli; Åkerla, Jonne; Honkanen, Teemu; Krogerus, Leena; Salo, Jarmo; Paavonen, Timo; Oksala, Niku

    2013-01-01

    CIP2A is overexpressed in many cancers, including esophageal squamous cell carcinoma. The regulation of c-MYC and CIP2A expression is characterized by a positive feedback mechanism facilitating the expression of both of them and accelerating cancer cell proliferation in gastric cancer. Increased CIP2A expression is a predictor of poor survival in some cancers. The incidence of positive CIP2A immunostaining and its association with c-MYC and its predictive value in esophageal adenocarcinoma are unknown. All esophageal adenocarcinoma patients from 1990 to 2007 with sufficient material for analysis of CIP2A and c-MYC in two university hospitals were included in the study. In addition, biopsies from Barrett's epithelium from the cancer patients and control tissue from normal esophageal mucosa adjacent to the tumor were included. CIP2A was moderately or strongly positive in 77.9 %, and c-MYC in 93.8 % of the cancer specimens. These frequencies were statistically different from the expression in normal esophageal epithelium. In addition, there was a positive correlation between CIP2A and c-MYC expression (p = 0.018). According to adjusted Cox regression survival analysis, CIP2A and c-MYC had no effect on survival. However, among patients with stage IVA-IVB cancer, there was a trend toward poor prognosis in CIP2A-positive patients. The expression of CIP2A and c-MYC was associated with each other, and their overexpression was found in most cases of esophageal adenocarcinoma. However, CIP2A and c-MYC had no effect on survival. PMID:23925667

  2. Carbon turnover in pore spaces - CIPS model approach

    NASA Astrophysics Data System (ADS)

    Kuka, Katrin

    2010-05-01

    The CIPS (Carbon turnover In Pore Spaces) model has been developed to overcome the constraints of conceptual pools and to get a better insight into the nature of carbon stabilization in soil (KUKA, 2007). This pure carbon turnover model was implemented in CANDY (CArbon and Nitrogen Dynamics) model system (Franko, 1995). The CIPS model did overcome the empirical pools taking into account soil structure effects. It is based on quality driven primary stabilisation mechanism (recalcitrance of SOM) and process driven secondary stabilisation mechanism (place of turnover) of SOM in soil. In addition to the division of SOM in the qualitative pools on the basis of chemical measurability, a dependence of the turnover conditions from the location of SOM in pore space is implemented taking into account different turnover conditions in the particular pore space and the accessibility for microbial biomass. The main assumption of the CIPS model is that the biological activity is not evenly distributed through the whole pore space. The pore space classes - micro, meso and macro pores - used in the model are marked by wilting point, field capacity and pore volume as a first approach. Because of the poor aeration in the micro pores they show very low biological activity leading to a strong protection of the carbon localized in this pore space. The biological active time (BAT) concept of the CANDY model was adapted to the CIPS model in order to calculate the distribution of biological activity for each pore space class. The reduction functions of the turnover active time concept of CANDY model, related to soil temperature, soil moisture, soil texture, relative air volume and distance to the soil surface are multiplied by the step width of calendar time producing the transformed time step as total BAT (BATtot). The calculated BATtot corresponds to the time that would be required under optimal conditions in the laboratory to perform the same turnover result as under the given

  3. Network for Translational Research - Cancer Imaging Program

    Cancer.gov

    Cooperative agreement (U54) awards to establish Specialized Research Resource Centers that will participate as members of a network of inter-disciplinary, inter-institutional research teams for the purpose of supporting translational research in optical imaging and/or spectroscopy in vivo, with an emphasis on multiple modalities.

  4. An image-processing program for automated counting

    USGS Publications Warehouse

    Cunningham, D.J.; Anderson, W.H.; Anthony, R.M.

    1996-01-01

    An image-processing program developed by the National Institute of Health, IMAGE, was modified in a cooperative project between remote sensing specialists at the Ohio State University Center for Mapping and scientists at the Alaska Science Center to facilitate estimating numbers of black brant (Branta bernicla nigricans) in flocks at Izembek National Wildlife Refuge. The modified program, DUCK HUNT, runs on Apple computers. Modifications provide users with a pull down menu that optimizes image quality; identifies objects of interest (e.g., brant) by spectral, morphometric, and spatial parameters defined interactively by users; counts and labels objects of interest; and produces summary tables. Images from digitized photography, videography, and high- resolution digital photography have been used with this program to count various species of waterfowl.

  5. Coordinated Investigation Programs: a status report

    NASA Astrophysics Data System (ADS)

    Stamper, Richard

    The building blocks of the IHY science program are the CIPs - the Coordinated Investigation Programs. Following a "bottom-up" philosophy, these are essentially autonomous investigations proposed and executed by self-selected groups of scientists that span the range of IHY science. Naturally, there are points of contact and overlap between the subjects of study of the various CIPS. To permit an easier appreciation of the scope of the program and of the connections between CIPs, and also to promote collaboration between them, the CIPs have therefore been grouped into seven "Disciplines": Solar; Heliospheric/Cosmic Rays; Magnetospheres; Ionized atmospheres; Neutral atmospheres; Climate; Meteors/Meteoroids/Interstellar Dust. A report will be given on the status of the CIPs and on the effectiveness of the mechanisms established for the IHY to support them individually and to build connections between them.

  6. CIP Training Manual: Collaborative Information Portal Advance Training Information for Field Test Participants

    NASA Technical Reports Server (NTRS)

    Schreiner, John; Clancy, Daniel (Technical Monitor)

    2002-01-01

    The Collaborative Information Portal (CIP) is a web-based information management and retrieval system. Its purpose is to provide users at MER (Mars Exploration Rover) mission operations with easy access to a broad range of mission data and products and contextual information such as the current operations schedule. The CIP web-server provides this content in a user customizable web-portal environment. Since CIP is still under development, only a subset of the full feature set will be available for the EDO field test. The CIP web-portal will be accessed through a standard web browser. CIP is intended to be intuitive and simple to use, however, at the training session, users will receive a one to two page reference guide, which should aid them in using CIP. Users must provide their own computers for accessing CIP during the field test. These computers should be configured with Java 1.3 and a Java 2 enabled browser. Macintosh computers should be running OS 10.1.3 or later. Classic Mac OS (OS 9) is not supported. For more information please read section 7.3 in the FIASCO Rover Science Operations Test Mission Plan. Several screen shots of the Beta Release of CIP are shown on the following pages.

  7. CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer.

    PubMed

    Peng, Bo; Lei, Ningjing; Chai, Yurong; Chan, Edward K L; Zhang, Jian-Ying

    2015-01-01

    The cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized endogenous inhibitor of the phosphatase activity of protein phosphatase 2A (PP2A), which extends the half-life of oncogenic protein c-myc and promotes in vivo tumor growth. The function of CIP2A in cancer progression is still poorly understood. To uncover the underlying mechanism of CIP2A-mediated cell proliferation, we implemented a two-dimensional electrophoresis (2DE)-based proteomic approach to examine lung cancer cell H1299 with and without CIP2A. We found 47 proteins differentially expressed where 19 proteins were upregulated and 28 proteins were downregulated. These were categorized into functional groups such as metabolism (25%), transcriptional and translational control (23%), and the signaling pathway and protein degradation (20%). On one hand, we validate our proteomic work by measuring the metabolic change. The knockdown of CIP2A decreased the expression of LDH-A as well as the enzymatic activity, accompanying with a decreased lactate production, an increased NADH/NAD+ ratio and ROS production. On the other hand, we found that CIP2A may regulate CREB activity through bioinformatics analysis. Our following experiments showed that, CIP2A positively regulated the phosphorylation of CREB in response to the serum treatment. Therefore, our proteomic study suggested that CIP2A mediates cancer progression through the metabolic pathway and intracellular signaling cascade. PMID:25325377

  8. Implementing a breast MR imaging program: all things considered.

    PubMed

    Raza, Sughra

    2010-05-01

    The role of magnetic resonance (MR) imaging in breast imaging and evaluation has increased rapidly. MR imaging now encompasses diagnostic evaluation as well as screening for breast cancer in high-risk groups, monitoring the extent of disease and the response to chemotherapy. It is expected that the utility of breast MR imaging will continue to increase, requiring additional facilities and expertise. Establishing a breast MR imaging program requires familiarity with several unique issues pertaining to the nature of this imaging modality. This article attempts to address some of these issues, including selection of a magnet based on needs of the particular practice and magnet field strength, selection of a dedicated breast coil, magnet location and siting, advantages and challenges of higher strength magnets such as 3 Tesla, establishing a referral base, scheduling of breast MR examinations, patient safety concerns, and examination interpretation and reporting. PMID:20494305

  9. High efficiency CIP 10-I personal inhalable aerosol sampler

    NASA Astrophysics Data System (ADS)

    Görner, P.; Wrobel, R.; Simon, X.

    2009-02-01

    The CIP 10 personal aerosol sampler was first developed by Courbon for sampling the respirable fraction of mining dust. This respirable aerosol sampler was further improved by Fabries, then selectors for sampling thoracic and inhalable aerosols were designed. Kenny et al. evaluated the particle-size dependent sampling efficiency of the inhalable version in a large-scale wind tunnel using a life-size dummy. The authors found that the overall sampling efficiency decreases more rapidly than the CEN-ISO-ACGIH target efficiency curve. Görner and Witschger measured the aspiration efficiency of the CIP 10 omni-directional inlet. They found that the aspiration efficiency was high enough for inhalable aerosol sampling. This result led to the conclusion that the low sampling efficiency is due to some internal losses of the aspirated particles before they reach the final sampling stage, namely the CIP 10 rotating filter. Based on the assumption that the inhalable particles are selected at selector aspiration level, an experimental research project was conducted to improve particle transmission to the collection stage of the sampler. Two different inhalable selectors were designed by Görner and tested in a laboratory wind tunnel. The transmission efficiency of both models was measured by Roger following an experimental protocol described by Witschger. The T-shaped air flow circuit was finally adopted to draw the aspirated particles into the final collection stage of the CIP 10. Actually, in this selector, the almost horizontally aspirated particles should be conducted vertically to the rotating cup. In two previous prototypes, particles could be deposited in certain places by inertia (where the aerosol was forced to deviate drastically) or by sedimentation (where the aerosol decelerated). The aerodynamic behaviour of the adopted solution causes the particles to accelerate radially between two horizontal plates before they enter a vertical tube. This acceleration avoids the

  10. FRAPTRAN Predictability of High Burnup Advanced Fuel Performance: Analysis of the CABRI CIP0-1 and CIP0-2 Experiments

    SciTech Connect

    Del Barrio, M.T.; Herranz, L.E.

    2007-07-01

    Adequacy of analytical tools to estimate advanced high burnup fuel during a power pulse need to be soundly proven. Most of models in codes dealing with transient are extrapolations of those developed for lower irradiations. In addition, lack of open information prevents often a proper account of mechanical properties of new advanced cladding material. These circumstances make experimental programs on high burnup fuel performance an indispensable tool to enhance safety codes predictability through building up sound databases on which models can be extended or developed and on which suitable code performance can be proven. The experiments CIP0-1 and CIP0-2, carried out on 2002 in the CABRI reactor, can be seen as reference tests to investigate high burnup fuel response to RIA transients. Fuel rods of up to 75 GWd/tU (average rod burnup) encapsulated in advanced cladding materials (ZIRLO and M5) were submitted to power pulses of about 30 ms of half maximum width that injected 90-100 cal/g after 1.2 s. None of the rodlets failed during the experiments, but they underwent deformation that was experimentally determined. The FRAPTRAN code has been used for the analysis of these RIA tests. The fuel rod characterization necessary for FRAPTRAN at the end of the base irradiation, prior to the transient, was provided by FRAPCON-3. An investigation of major deviations of fuel rod characterization at the end of the base irradiation has highlighted that thermal uncertainties could result in outstanding discrepancies in FGR estimates. Transient comparison with the available data shows that FRAPTRAN presents a relatively good agreement in permanent clad hoop strain and overestimates significantly the axial elongation of the cladding. The potential effect of approximations made in describing the cladding mechanical behavior, the fuel-to-clad relative movement and the pre-transient gap width, have been all discussed. Given existing uncertainties, a conclusive statement could not be

  11. A new programming metaphor for image processing procedures

    NASA Technical Reports Server (NTRS)

    Smirnov, O. M.; Piskunov, N. E.

    1992-01-01

    Most image processing systems, besides an Application Program Interface (API) which lets users write their own image processing programs, also feature a higher level of programmability. Traditionally, this is a command or macro language, which can be used to build large procedures (scripts) out of simple programs or commands. This approach, a legacy of the teletypewriter has serious drawbacks. A command language is clumsy when (and if! it attempts to utilize the capabilities of a multitasking or multiprocessor environment, it is but adequate for real-time data acquisition and processing, it has a fairly steep learning curve, and the user interface is very inefficient,. especially when compared to a graphical user interface (GUI) that systems running under Xll or Windows should otherwise be able to provide. ll these difficulties stem from one basic problem: a command language is not a natural metaphor for an image processing procedure. A more natural metaphor - an image processing factory is described in detail. A factory is a set of programs (applications) that execute separate operations on images, connected by pipes that carry data (images and parameters) between them. The programs function concurrently, processing images as they arrive along pipes, and querying the user for whatever other input they need. From the user's point of view, programming (constructing) factories is a lot like playing with LEGO blocks - much more intuitive than writing scripts. Focus is on some of the difficulties of implementing factory support, most notably the design of an appropriate API. It also shows that factories retain all the functionality of a command language (including loops and conditional branches), while suffering from none of the drawbacks outlined above. Other benefits of factory programming include self-tuning factories and the process of encapsulation, which lets a factory take the shape of a standard application both from the system and the user's point of view, and

  12. The vectorization of a ray tracing program for image generation

    NASA Technical Reports Server (NTRS)

    Plunkett, D. J.; Cychosz, J. M.; Bailey, M. J.

    1984-01-01

    Ray tracing is a widely used method for producing realistic computer generated images. Ray tracing involves firing an imaginary ray from a view point, through a point on an image plane, into a three dimensional scene. The intersections of the ray with the objects in the scene determines what is visible at the point on the image plane. This process must be repeated many times, once for each point (commonly called a pixel) in the image plane. A typical image contains more than a million pixels making this process computationally expensive. A traditional ray tracing program processes one ray at a time. In such a serial approach, as much as ninety percent of the execution time is spent computing the intersection of a ray with the surface in the scene. With the CYBER 205, many rays can be intersected with all the bodies im the scene with a single series of vector operations. Vectorization of this intersection process results in large decreases in computation time. The CADLAB's interest in ray tracing stems from the need to produce realistic images of mechanical parts. A high quality image of a part during the design process can increase the productivity of the designer by helping him visualize the results of his work. To be useful in the design process, these images must be produced in a reasonable amount of time. This discussion will explain how the ray tracing process was vectorized and gives examples of the images obtained.

  13. CIP2A oncoprotein controls cell growth and autophagy through mTORC1 activation

    PubMed Central

    Puustinen, Pietri; Rytter, Anna; Mortensen, Monika; Kohonen, Pekka; Moreira, José M.

    2014-01-01

    mTORC1 (mammalian target of rapamycin complex 1) integrates information regarding availability of nutrients and energy to coordinate protein synthesis and autophagy. Using ribonucleic acid interference screens for autophagy-regulating phosphatases in human breast cancer cells, we identify CIP2A (cancerous inhibitor of PP2A [protein phosphatase 2A]) as a key modulator of mTORC1 and autophagy. CIP2A associates with mTORC1 and acts as an allosteric inhibitor of mTORC1-associated PP2A, thereby enhancing mTORC1-dependent growth signaling and inhibiting autophagy. This regulatory circuit is reversed by ubiquitination and p62/SQSTM1-dependent autophagic degradation of CIP2A and subsequent inhibition of mTORC1 activity. Consistent with CIP2A’s reported ability to protect c-Myc against proteasome-mediated degradation, autophagic degradation of CIP2A upon mTORC1 inhibition leads to destabilization of c-Myc. These data characterize CIP2A as a distinct regulator of mTORC1 and reveals mTORC1-dependent control of CIP2A degradation as a mechanism that links mTORC1 activity with c-Myc stability to coordinate cellular metabolism, growth, and proliferation. PMID:24590173

  14. CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations.

    PubMed

    Khanna, Anchit; Rane, Jayant K; Kivinummi, Kati K; Urbanucci, Alfonso; Helenius, Merja A; Tolonen, Teemu T; Saramäki, Outi R; Latonen, Leena; Manni, Visa; Pimanda, John E; Maitland, Norman J; Westermarck, Jukka; Visakorpi, Tapio

    2015-08-14

    Residual androgen receptor (AR)-signaling and presence of cancer stem-like cells (SCs) are the two emerging paradigms for clinically challenging castration-resistant prostate cancer (CRPC). Therefore, identification of AR-target proteins that are also overexpressed in the cancer SC population would be an attractive therapeutic approach.Our analysis of over three hundred clinical samples and patient-derived prostate epithelial cultures (PPECs), revealed Cancerous inhibitor of protein phosphatase 2A (CIP2A) as one such target. CIP2A is significantly overexpressed in both hormone-naïve prostate cancer (HN-PC) and CRPC patients . CIP2A is also overexpressed, by 3- and 30-fold, in HN-PC and CRPC SCs respectively. In vivo binding of the AR to the intronic region of CIP2A and its functionality in the AR-moderate and AR-high expressing LNCaP cell-model systems is also demonstrated. Further, we show that AR positively regulates CIP2A expression, both at the mRNA and protein level. Finally, CIP2A depletion reduced cell viability and colony forming efficiency of AR-independent PPECs as well as AR-responsive LNCaP cells, in which anchorage-independent growth is also impaired.These findings identify CIP2A as a common denominator for AR-signaling and cancer SC functionality, highlighting its potential therapeutic significance in the most clinically challenging prostate pathology: castration-resistant prostate cancer. PMID:25965834

  15. Role of scaffolding protein CipC of Clostridium cellulolyticum in cellulose degradation.

    PubMed Central

    Pagès, S; Gal, L; Bélaïch, A; Gaudin, C; Tardif, C; Bélaïch, J P

    1997-01-01

    The role of a miniscaffolding protein, miniCipC1, forming part of Clostridium cellulolyticum scaffolding protein CipC in insoluble cellulose degradation was investigated. The parameters of the binding of miniCipC1, which contains a family III cellulose-binding domain (CBD), a hydrophilic domain, and a cohesin domain, to four insoluble celluloses were determined. At saturating concentrations, about 8.2 micromol of protein was bound per g of bacterial microcrystalline cellulose, while Avicel, colloidal Avicel, and phosphoric acid-swollen cellulose bound 0.28, 0.38, and 0.55 micromol of miniCipC1 per g, respectively. The dissociation constants measured varied between 1.3 x 10(-7) and 1.5 x 10(-8) M. These results are discussed with regard to the properties of the various substrates. The synergistic action of miniCipC1 and two forms of endoglucanase CelA (with and without the dockerin domain [CelA2 and CelA3, respectively]) in cellulose degradation was also studied. Although only CelA2 interacted with miniCipC1 (K(d), 7 x 10(-9) M), nonhydrolytic miniCipC1 enhanced the activities of endoglucanases CelA2 and CelA3 with all of the insoluble substrates tested. This finding shows that miniCipC1 plays two roles: it increases the enzyme concentration on the cellulose surface and enhances the accessibility of the enzyme to the substrate by modifying the structure of the cellulose, leading to an increased available cellulose surface area. In addition, the data obtained with a hybrid protein, CelA3-CBD(CipC), which was more active towards all of the insoluble substrates tested confirm that the CBD of the scaffolding protein plays an essential role in cellulose degradation. PMID:9139893

  16. Fundus Autofluorescence Imaging in an Ocular Screening Program

    PubMed Central

    Kolomeyer, A. M.; Nayak, N. V.; Szirth, B. C.; Khouri, A. S.

    2012-01-01

    Purpose. To describe integration of fundus autofluorescence (FAF) imaging into an ocular screening program. Methods. Fifty consecutive screening participants were included in this prospective pilot imaging study. Color and FAF (530/640 nm exciter/barrier filters) images were obtained with a 15.1MP Canon nonmydriatic hybrid camera. A clinician evaluated the images on site to determine need for referral. Visual acuity (VA), intraocular pressure (IOP), and ocular pathology detected by color fundus and FAF imaging modalities were recorded. Results. Mean ± SD age was 47.4 ± 17.3 years. Fifty-two percent were female and 58% African American. Twenty-seven percent had a comprehensive ocular examination within the past year. Mean VA was 20/39 in the right eye and 20/40 in the left eye. Mean IOP was 15 mmHg bilaterally. Positive color and/or FAF findings were identified in nine (18%) individuals with diabetic retinopathy or macular edema (n = 4), focal RPE defects (n = 2), age-related macular degeneration (n = 1), central serous retinopathy (n = 1), and ocular trauma (n = 1). Conclusions. FAF was successfully integrated in our ocular screening program and aided in the identification of ocular pathology. Larger studies examining the utility of this technology in screening programs may be warranted. PMID:23316224

  17. Free viewpoint image generation using multi-pass dynamic programming

    NASA Astrophysics Data System (ADS)

    Fukushima, Norishige; Yendo, Tomohiro; Fujii, Toshiaki; Tanimoto, Masayuki

    2007-02-01

    Ray-Space is categorized by Image-Based Rendering (IBR), thus generated views have photo-realistic quality. While this method has the performance of high quality imaging, this needs a lot of images or cameras. The reason why that is Ray-Space requires various direction's and position's views instead of 3D depth information. In this paper, we reduce that flood of information using view-centered ray interpolation. View-centered interpolation means estimating view dependent depth value (or disparity map) at generating view-point and interpolating that of pixel values using multi-view images and depth information. The combination of depth estimation and interpolation realizes the rendering photo-realistic images effectively. Unfortunately, however, if depth estimation is week or mistake, a lot of artifacts appear in creating images. Thus powerful depth estimation method is required. When we render the free viewpoint images video, we perform the depth estimation at every frame. Thus we want to keep a lid on computing cost. Our depth estimation method is based on dynamic programming (DP). This method optimizes and solves depth images at the weak matching area with high-speed performance. But scan-line noises become appeared because of the limit of DP. So, we perform the DP multi-direction pass and sum-up the result of multi-passed DPs. Our method fulfills the low computation cost and high depth estimation performance.

  18. Role of "oncogenic nexus" of CIP2A in breast oncogenesis: how does it work?

    PubMed

    De, Pradip; Carlson, Jennifer H; Leyland-Jones, Brian; Dey, Nandini

    2015-01-01

    The CIP2A gene is an oncogene associated with solid and hematologic malignancies [1]. CIP2A protein is an oncoprotein and a potential cancer therapy target [2]. Literature shows that CIP2A inhibits the tumor suppressor protein PP2A [3] which downregulates phophorylation of AKT, a hallmark of cancers [4] and stabilizes the proto-oncogene, c-MYC in tumor cells [5], the comprehensive action of CIP2A and its functional interaction(s) with other oncoproteins and tumor suppressors is not clearly established. Recently we tried to put forward a contextual mode-of-action of CIP2A protein in a review which proposed that CIP2A influences oncogenesis via an "oncogenic nexus" [1]. In this review we critically evaluated the potential relevance of the mode-of-action of the "oncogenic nexus" of CIP2A in breast carcinogenesis and appraised the role of this nexus in different PAM50 luminal A, PAM50 luminal B, PAM50 HER2-enriched and PAM50 basal BC. This review has a novel approach. Here we have not only compiled and discussed the latest developments in this field but also presented data obtained from c-BioPortal and STRING10 in order to substantiate our view regarding the mode-of-action of the "oncogenic nexus" of CIP2A. We functionally correlated alterations of genes pertaining to the "oncogenic nexus" of CIP2A with protein-protein interactions between the different components of the nexus including (1) subunits of PP2A, (2) multiple transcription factors including MYC oncogene and (3) components of the PI3K-mTOR and the MAPK-ERK oncogenic pathways. Using these proteins as "input" to STRING10 we studied the association, Action view, at the highest Confidence level. OncoPrints (c-BioPortal) showed alterations (%) of regulatory subunits genes of PP2A (PPP2R1A and PPP2R1B) along with alterations of CIP2A in breast invasive carcinoma (TCGA, Nature 2012 & TCGA, Provisional). Similar genetic alterations of PP2A were also observed in samples of breast tumors at our Avera Research

  19. Wideband electromagnetic scattering program. Fourier-based radar imaging techniques

    NASA Astrophysics Data System (ADS)

    Chan, B. L.; Young, J. D.; Rudduck, R. C.

    1993-09-01

    This report describes the implementation of Fourier based radar imaging algorithms in a computer program. In particular, the algorithms are derived for wide bandwidth and for specific geometries. These geometries are often measured by radar cross section measurement systems such as compact ranges and near field linear synthetic aperture radar systems. The limitations of different implementations of the algorithms are presented. Imaging results from radar measurements are also presented for an F-4 fighter aircraft, an M35 truck (1/16 scale model), and a forest.

  20. Cleaning validation 2: development and validation of an ion chromatographic method for the detection of traces of CIP-100 detergent.

    PubMed

    Resto, Wilfredo; Hernández, Darimar; Rey, Rosamil; Colón, Héctor; Zayas, José

    2007-05-01

    A cleaning validation method, ion chromatographic method with conductivity detection was developed and validated for the determination of traces of a clean-in-place (CIP) detergent. It was shown to be linear with a squared correlation coefficient (r(2)) of 0.9999 and average recoveries of 71.4% (area response factor) from stainless steel surfaces and 101% from cotton. The repeatability was found to be 2.17% and an intermediate precision of 1.88% across the range. The method was also shown to be sensitive with a detection limit (DL) of 0.13 ppm and a quantitation limit (QL) of 0.39 ppm for EDTA, which translates to less than 1 microL of CIP diluted in 100mL of diluent in both cases. The EDTA signal was well resolved from typical ions encountered in water samples or any other interference presented from swabs and surfaces. The method could be applied to cleaning validation samples. The validated method could be included as a suitable one for rapid and reliable cleaning validation program. PMID:17344013

  1. IMFIT: A Fast, Flexible New Program for Astronomical Image Fitting

    NASA Astrophysics Data System (ADS)

    Erwin, Peter

    2015-02-01

    I describe a new, open-source astronomical image-fitting program called IMFIT, specialized for galaxies but potentially useful for other sources, which is fast, flexible, and highly extensible. A key characteristic of the program is an object-oriented design that allows new types of image components (two-dimensional surface-brightness functions) to be easily written and added to the program. Image functions provided with IMFIT include the usual suspects for galaxy decompositions (Sérsic, exponential, Gaussian), along with Core-Sérsic and broken-exponential profiles, elliptical rings, and three components that perform line-of-sight integration through three-dimensional luminosity-density models of disks and rings seen at arbitrary inclinations. Available minimization algorithms include Levenberg-Marquardt, Nelder-Mead simplex, and Differential Evolution, allowing trade-offs between speed and decreased sensitivity to local minima in the fit landscape. Minimization can be done using the standard χ2 statistic (using either data or model values to estimate per-pixel Gaussian errors, or else user-supplied error images) or Poisson-based maximum-likelihood statistics; the latter approach is particularly appropriate for cases of Poisson data in the low-count regime. I show that fitting low-signal-to-noise ratio galaxy images using χ2 minimization and individual-pixel Gaussian uncertainties can lead to significant biases in fitted parameter values, which are avoided if a Poisson-based statistic is used; this is true even when Gaussian read noise is present.

  2. IMFIT: A FAST, FLEXIBLE NEW PROGRAM FOR ASTRONOMICAL IMAGE FITTING

    SciTech Connect

    Erwin, Peter

    2015-02-01

    I describe a new, open-source astronomical image-fitting program called IMFIT, specialized for galaxies but potentially useful for other sources, which is fast, flexible, and highly extensible. A key characteristic of the program is an object-oriented design that allows new types of image components (two-dimensional surface-brightness functions) to be easily written and added to the program. Image functions provided with IMFIT include the usual suspects for galaxy decompositions (Sérsic, exponential, Gaussian), along with Core-Sérsic and broken-exponential profiles, elliptical rings, and three components that perform line-of-sight integration through three-dimensional luminosity-density models of disks and rings seen at arbitrary inclinations. Available minimization algorithms include Levenberg-Marquardt, Nelder-Mead simplex, and Differential Evolution, allowing trade-offs between speed and decreased sensitivity to local minima in the fit landscape. Minimization can be done using the standard χ{sup 2} statistic (using either data or model values to estimate per-pixel Gaussian errors, or else user-supplied error images) or Poisson-based maximum-likelihood statistics; the latter approach is particularly appropriate for cases of Poisson data in the low-count regime. I show that fitting low-signal-to-noise ratio galaxy images using χ{sup 2} minimization and individual-pixel Gaussian uncertainties can lead to significant biases in fitted parameter values, which are avoided if a Poisson-based statistic is used; this is true even when Gaussian read noise is present.

  3. STEM image simulation with hybrid CPU/GPU programming.

    PubMed

    Yao, Y; Ge, B H; Shen, X; Wang, Y G; Yu, R C

    2016-07-01

    STEM image simulation is achieved via hybrid CPU/GPU programming under parallel algorithm architecture to speed up calculation on a personal computer (PC). To utilize the calculation power of a PC fully, the simulation is performed using the GPU core and multi-CPU cores at the same time to significantly improve efficiency. GaSb and an artificial GaSb/InAs interface with atom diffusion have been used to verify the computation. PMID:27093687

  4. Imfit: A Fast, Flexible Program for Astronomical Image Fitting

    NASA Astrophysics Data System (ADS)

    Erwin, Peter

    2014-08-01

    Imift is an open-source astronomical image-fitting program specialized for galaxies but potentially useful for other sources, which is fast, flexible, and highly extensible. Its object-oriented design allows new types of image components (2D surface-brightness functions) to be easily written and added to the program. Image functions provided with Imfit include Sersic, exponential, and Gaussian galaxy decompositions along with Core-Sersic and broken-exponential profiles, elliptical rings, and three components that perform line-of-sight integration through 3D luminosity-density models of disks and rings seen at arbitrary inclinations. Available minimization algorithms include Levenberg-Marquardt, Nelder-Mead simplex, and Differential Evolution, allowing trade-offs between speed and decreased sensitivity to local minima in the fit landscape. Minimization can be done using the standard chi^2 statistic (using either data or model values to estimate per-pixel Gaussian errors, or else user-supplied error images) or the Cash statistic; the latter is particularly appropriate for cases of Poisson data in the low-count regime. The C++ source code for Imfit is available under the GNU Public License.

  5. An interactive lake survey program. [airborne multispectral sensor image processing

    NASA Technical Reports Server (NTRS)

    Smith, A. Y.

    1977-01-01

    Consideration is given to the development and operation of the interactive lake survey program developed by the Jet Propulsion Laboratory and the Environmental Protection Agency. The program makes it possible to locate, isolate, and store any number of water bodies on the basis of a given digital image. The stored information may be used to generate statistical analyses of each body of water including the lake surface area and the shoreline perimeter. The hardware includes a 360/65 host computer, a Ramtek G100B display controller, and a trackball cursor. The system is illustrated by the LAKELOC operation as it would be applied to a Landsat scene, noting the FARINA and STATUS programs. The water detection algorithm, which increases the accuracy with which water and land data may be separated, is discussed.

  6. PC-based digital imaging for storing microscopy images for surveillance programs

    SciTech Connect

    Schleitweiler, P.M.; Ransick, M.H.

    1990-01-01

    Advances in video technology and digital imaging have resulted in the ability to produce an image in high quality digital format. Images that are created and viewed in a digital format can be quantitatively measured and then stored to disk for later examination. Write-once read many (WORM) optical disks are excellent media for permanently archiving digital images. One of the best applications for this image storage technology is storage of microscopy images for surveillance programs. Currently, the most common type of recording medium used in service laboratories is Polaroid instant developing film. The short developing time and ease in processing make it swell suited for most high volume laboratories. But the convenience of this film has a substantial price tag. Depending on the type of film, each picture can cost about $1.50. The two metallurgical support laboratories at Mound are frequently required to make multiple copies for design agencies or program managers. Permanent archiving of photos is required for both WR and surveillance samples. This has made Polaroid film a significant part of the expense budget. In addition, the thousands of photos taken annually present a considerable storage problem. 2 figs.

  7. Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling

    PubMed Central

    Chen, Yolande; Aardema, Jorie; Kale, Sayali; Whichard, Zakary L.; Awomolo, Arinola; Blanchard, Elisabeth; Chang, Brian; Myers, David R.; Ju, Lining; Tran, Reginald; Reece, David; Christensen, Hilary; Boukour, Siham; Debili, Najet; Strom, Ted S.; Rawlings, David; Vázquez, Francisco X.; Voth, Gregory A.; Zhu, Cheng; Kahr, Walter H. A.; Lam, Wilbur A.

    2013-01-01

    Megakaryocytes generate platelets through extensive reorganization of the cytoskeleton and plasma membrane. Cdc42 interacting protein 4 (CIP4) is an F-BAR protein that localizes to membrane phospholipids through its BAR domain and interacts with Wiskott-Aldrich Syndrome Protein (WASP) via its SRC homology 3 domain. F-BAR proteins promote actin polymerization and membrane tubulation. To study its function, we generated CIP4-null mice that displayed thrombocytopenia similar to that of WAS− mice. The number of megakaryocytes and their progenitors was not affected. However, the number of proplatelet protrusions was reduced in CIP4-null, but not WAS−, megakaryocytes. Electron micrographs of CIP4-null megakaryocytes showed an altered demarcation membrane system. Silencing of CIP4, not WASP, expression resulted in fewer proplatelet-like extensions. Fluorescence anisotropy studies showed that loss of CIP4 resulted in a more rigid membrane. Micropipette aspiration demonstrated decreased cortical actin tension in megakaryocytic cells with reduced CIP4 or WASP protein. These studies support a new biophysical mechanism for platelet biogenesis whereby CIP4 enhances the complex, dynamic reorganization of the plasma membrane (WASP independent) and actin cortex network (as known for WASP and cortical actin) to reduce the work required for generating proplatelets. CIP4 is a new component in the highly coordinated system of megakaryocytic membrane and cytoskeletal remodeling affecting platelet production. PMID:23881916

  8. Embossed radiography utilizing an image-shifting subtraction program

    NASA Astrophysics Data System (ADS)

    Sato, Eiichi; Osawa, Akihiro; Matsukiyo, Hiroshi; Enomoto, Toshiyuki; Watanabe, Manabu; Takahashi, Kiyomi; Sato, Shigehiro; Ogawa, Akira; Onagawa, Jun

    2010-07-01

    We developed an image-shifting subtraction program and carried out embossed radiography (ER) utilizing single- and dual-energy subtractions. In particular, dual-energy subtraction was carried out to decrease the absorption contrast of unnecessary regions. The contrast resolution of a target region was increased using the subtraction program and a linear-contrast system in a flat panel detector (FPD). The X-ray generator had a 100 μm-focus tube, and the subtractions were performed at tube voltages of 40 and 70 kV, a tube current of 0.50 mA, and an X-ray exposure time of 5.0 s. ER was achieved with cohesion imaging using the FPD with pixel sizes of 48×48 μm 2, and the shifting dimension of an object in the horizontal and vertical directions ranged from 48 to 96 μm. At a shifting distance of 96 μm, the spatial resolutions in the horizontal and vertical directions measured with a lead test chart were both 83 μm. In ER of animal phantoms, we obtained high-contrast embossed images of fine bones, gadolinium oxide particles in blood vessels, iodine-based microspheres in coronary arteries approximately 100 μm in diameter.

  9. Magnification Embossed Radiography Utilizing Image-Shifting Subtraction Program

    NASA Astrophysics Data System (ADS)

    Akihiro Osawa,; Manabu Watanabe,; Eiichi Sato,; Hiroshi Matsukiyo,; Toshiyuki Enomoto,; Jiro Nagao,; Purkhet Abderyim,; Katsuo Aizawa,; Etsuro Tanaka,; Hidezo Mori,; Toshiaki Kawai,; Akira Ogawa,; Kiyomi Takahashi,; Shigehiro Sato,; Jun Onagawa,

    2010-03-01

    We developed an image-shifting subtraction program and carried out magnification embossed radiography (MER) utilizing single- and dual-energy subtractions. In particular, dual-energy subtraction was carried out to decrease the absorption contrast of unnecessary regions. The contrast resolution of the target region was increased by the use of subtraction software and a linear-contrast system in a flat-panel detector (FPD). The X-ray generator had a 100-μm-focus tube, and the subtractions were performed at tube voltages of 40 and 70 kV, a tube current of 0.50 mA, and an X-ray exposure time of 5.0 s. MER images with threefold magnification were obtained using the FPD with a pixel size of 48× 48 μm2, and the shifting dimensions of the imaged object in the horizontal and vertical directions ranged from 48 to 192 μm. At a shifting distance ranging from 48 to 144 μm, the spatial resolutions in the horizontal and vertical directions measured with a lead test chart were both 50 μm. In the MER of nonliving animals, we obtained high-contrast embossed images of fine bones, gadolinium oxide particles in blood vessels, and iodine-based microspheres in coronary arteries of approximately 100 μm diameter.

  10. Magnification Embossed Radiography Utilizing Image-Shifting Subtraction Program

    NASA Astrophysics Data System (ADS)

    Osawa, Akihiro; Watanabe, Manabu; Sato, Eiichi; Matsukiyo, Hiroshi; Enomoto, Toshiyuki; Nagao, Jiro; Abderyim, Purkhet; Aizawa, Katsuo; Tanaka, Etsuro; Mori, Hidezo; Kawai, Toshiaki; Ogawa, Akira; Takahashi, Kiyomi; Sato, Shigehiro; Onagawa, Jun

    2010-03-01

    We developed an image-shifting subtraction program and carried out magnification embossed radiography (MER) utilizing single- and dual-energy subtractions. In particular, dual-energy subtraction was carried out to decrease the absorption contrast of unnecessary regions. The contrast resolution of the target region was increased by the use of subtraction software and a linear-contrast system in a flat-panel detector (FPD). The X-ray generator had a 100-µm-focus tube, and the subtractions were performed at tube voltages of 40 and 70 kV, a tube current of 0.50 mA, and an X-ray exposure time of 5.0 s. MER images with threefold magnification were obtained using the FPD with a pixel size of 48×48 µm2, and the shifting dimensions of the imaged object in the horizontal and vertical directions ranged from 48 to 192 µm. At a shifting distance ranging from 48 to 144 µm, the spatial resolutions in the horizontal and vertical directions measured with a lead test chart were both 50 µm. In the MER of nonliving animals, we obtained high-contrast embossed images of fine bones, gadolinium oxide particles in blood vessels, and iodine-based microspheres in coronary arteries of approximately 100 µm diameter.

  11. PUPA: a pulse programming assistant for NMR imaging

    SciTech Connect

    Foxvog, D.; Li, X.; Vargas, J.E.; Bourne, J.R.; Sztipanovits, J.; Mushlin, R.; Harrison, C.G.

    1987-12-01

    The design of pulse programs for magnetic resonance imaging (MRI) experiments is tedious and complex, requiring a deep understanding of the interactions that exist between magnetic fields generated during an MRI experiment. This paper describes an intelligent system that understands how to construct the multichannel temporal sequences of pulses needed to control an MRI experiment. PUPA, the PUlse Programmers Assistant, provides assistance to a relatively naive user of MRI systems. Knowledge is coded in the form of rules and semantic networks. A natural language facility and menu system are provided for communication with the user.

  12. Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1

    PubMed Central

    Trakala, Marianna; Fernández-Miranda, Gonzalo; Pérez de Castro, Ignacio; Heeschen, Christopher; Malumbres, Marcos

    2013-01-01

    Aurora kinase B is a critical component of the chromosomal passenger complex, which is involved in the regulation of microtubule-kinetochore attachments and cytokinesis. By using conditional knockout cells and chemical inhibition, we show here that inactivation of Aurora B results in delayed G1/S transition and premature mitotic exit. Aurora B deficiency results in delayed DNA replication in cultured fibroblasts as well as liver cells after hepatectomy. This is accompanied by increased transcription of the cell cycle inhibitor p21Cip1. Lack of Aurora B does not prevent mitotic entry but results in a premature exit from prometaphase in the presence of increased p21Cip1-Cdk1 inactive complexes. Aurora B-null cells display reduced degradation of cyclin B1, suggesting the presence of phenomenon known as adaptation to the mitotic checkpoint, previously described in yeast. Elimination of p21Cip1 rescues Cdk1 activity and prevents premature mitotic exit in Aurora B-deficient cells. These results suggest that Aurora B represses p21Cip1, preventing delayed DNA replication, Cdk inhibition and premature mitotic exit. The upregulation of p21Cip1 observed after inhibition of Aurora B may have important implications in cell cycle progression, tetraploidy, senescence or cancer therapy. PMID:23428904

  13. CIP-MOC Modeling of Seismic Wave Propagation in Elastic Media

    NASA Astrophysics Data System (ADS)

    Yoshimi, M.

    2004-12-01

    In many fields such as hydrodynamics and MHD, the CIP method, an upwind difference hyperbolic equation solver, has widely been employed for advection calculation. The CIP scheme was constructed considering that an advected property and its spatial derivative follow same advection equation. This effects low numerical dispersion and relaxed CFL condition in the advection calculation. In the present work, we developed a CIP-MOC (CIP with method of characteristics) scheme for seismic wave propagation in 3D elastic heterogeneous media with flat free surface. 3D elastic wave equations in velocity-stress formulation and their spatial derivatives, as well, are converted into sets of 1D advection equations and non-advection equations for each direction (x,y,z in Cartesian coodinate system) with the method of characteristics. Since the Riemann invariant of each advection equation consists of stress and velocity, updatings of velocity and stress are simultaneous and a collocated grid system is employed. A free surface is modeled as a zero-stress surface. A reflection free boundary is installed by considering no incident wave comes from outside of the boundary. A double coupled seismic point source is introduced as external point stresses. Overall scheme is made up of multiphases employing time-splitting and directional-splitting techniques. Each time step is composed of three directional updating phases each for wave propagation in x, y and z direction. Each directional updating phase is made up of advection phase and non-advection phase. In the advection phase, advection equations are solved with the CIP method. In the non-advection phases, non-advetion equations and boundary conditions are evaluated with central finite differences. We conducted CIP-MOC seismic wave propagation simulations in a half-space, layered and fully heterogeneous media for embedded point source. By comparing our products with those produced with discrete wavenumber method and finite difference method

  14. A numerical procedure — CIP — to solve all phases of matter together

    NASA Astrophysics Data System (ADS)

    Yabe, Takashi; Zhang, Yan; Xiao, Feng

    We have succeeded for the first time to simulate dynamic phase transition from metal to vapor. This success is due to the CIP (Cubic-Interporated Pseudoparticle/Propagation) method that can treat solid, liquid and gas together and can trace a sharp interface with almost one grid. The strategy of the CIP method and its various modifications are reviewed including application to various aspects of multi-phase flow such as laser-induced evaporation, slamming of ship and formation of milk crown in three dimensions.

  15. xdamp An IDL-based data and image manipulation program

    Energy Science and Technology Software Center (ESTSC)

    2002-06-26

    xdamp is a graphical user interface (GUI) designed to allow the user to manipulate two-dimensional waveforms (data vs. time) and images (usually digitized radiographic film or digital camera outputs)that are typical of electrical engineering applications. A typical single data set from these applications will generate ~ 100 time-dependent waveforms and possibly a few images. xdamp can manipulate waveforms both in time and in amplitude. Typical operations are: time shifting, truncating before or after a specificmore » time, adding, multiplying, integrating, and averaging. When manipulating images, the spatial dimensions are maintained as important data. Standard electrical engineering quantities (maximum, minimum, fully-width-at-half-maximum, rise-time, mean, standard deviation) are calculated for each waveform and automatically displayed. Annotation can be added to each waveform and/or image and the overall file so that the data contains full documentation. PostScript printing is supported. xdamp supports full audit trail information on each waveform. Data are saved using the Hierarchical Data Format (HDF) from the National Center for Supercomputing Applications. xdamp uses the Interactive Data Language (IDL) from Research Systems, Inc., a Xerox company, as the processing engine. The entire program is written inthe IDL macro language to enhance portability. IDL is currently supported on the macintosh, alpha computers, Windows-based computers, and on virtually all UNIX platforms. Portability to all of these platforms has been verified. xdamp has a full internal language for creating macros useful for repetitive data reduction and analysis. xdamp can manipulate waveforms both in time and in amplitude. Some advanced features included are: the ability to compare waveforms in time and amplitude, the ability to generate high-frequence cable compensators, both integration and differentiation of waveforms, Fourier transforms of waveforms, and automatic execution of

  16. xdamp An IDL-based data and image manipulation program

    SciTech Connect

    Ballard, William P.

    2002-06-26

    xdamp is a graphical user interface (GUI) designed to allow the user to manipulate two-dimensional waveforms (data vs. time) and images (usually digitized radiographic film or digital camera outputs)that are typical of electrical engineering applications. A typical single data set from these applications will generate ~ 100 time-dependent waveforms and possibly a few images. xdamp can manipulate waveforms both in time and in amplitude. Typical operations are: time shifting, truncating before or after a specific time, adding, multiplying, integrating, and averaging. When manipulating images, the spatial dimensions are maintained as important data. Standard electrical engineering quantities (maximum, minimum, fully-width-at-half-maximum, rise-time, mean, standard deviation) are calculated for each waveform and automatically displayed. Annotation can be added to each waveform and/or image and the overall file so that the data contains full documentation. PostScript printing is supported. xdamp supports full audit trail information on each waveform. Data are saved using the Hierarchical Data Format (HDF) from the National Center for Supercomputing Applications. xdamp uses the Interactive Data Language (IDL) from Research Systems, Inc., a Xerox company, as the processing engine. The entire program is written inthe IDL macro language to enhance portability. IDL is currently supported on the macintosh, alpha computers, Windows-based computers, and on virtually all UNIX platforms. Portability to all of these platforms has been verified. xdamp has a full internal language for creating macros useful for repetitive data reduction and analysis. xdamp can manipulate waveforms both in time and in amplitude. Some advanced features included are: the ability to compare waveforms in time and amplitude, the ability to generate high-frequence cable compensators, both integration and differentiation of waveforms, Fourier transforms of waveforms, and automatic execution of macros

  17. P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells.

    PubMed

    Geller, James I; Szekely-Szucs, Kinga; Petak, Istvan; Doyle, Belinda; Houghton, Janet A

    2004-09-01

    We have demonstrated previously that interferon (IFN)-gamma sensitizes human colon carcinoma cell lines to the cytotoxic effects of 5-fluorouracil combined with leucovorin and to the thymidylate synthase inhibitor, ZD9331, dependent on thymineless stress-induced DNA damage, independent of p53. Here we demonstrate that the cyclin-dependent kinase (CDK) inhibitor p21(Cip1) regulates thymineless stress-induced cytotoxicity in these cells. HCT116 wild-type (wt) and p53-/- cells underwent apoptosis and loss in clonogenic survival when exposed to ZD9331, whereas p21Cip1-/- cells were resistant. In contrast, IFN-gamma induced marked cytotoxicity in p21Cip1-/- cells only. ZD9331 induced p21Cip1 up-regulation in all of the cell lines examined, as did thymidine deprivation in thymidylate synthase-deficient (thymidylate synthase-) cells. Furthermore, selective induction of p21Cip1 in RKO was sufficient to induce apoptosis. P21Cip1, cdk1, cdk2, and cyclin E mRNA expression increased coincident with S-phase accumulation in HT29 cells treated with ZD9331 or 5fluorouracil/leucovorin, as demonstrated by cDNA microarray analyses. Cell cycle analyses revealed that HCT116 wt and p21Cip1 -/- cells accumulated in S phase within 24 h of ZD9331 exposure; however, wt cells exited S-phase more rapidly, where apoptosis occurred before mitosis, either in late S or G2. Finally, the CDK inhibitor roscovitine potentiated the cytotoxic activity of ZD9331 in both wt and p21Cip1-/- cells, strongly suggesting a role for p21Cip1-dependent CDK inhibition in cytotoxicity induced by thymidylate synthase inhibition. In summary, p21Cip1 positively regulates the cytotoxic action of thymidylate synthase inhibitors, negatively regulates the cytotoxic action of IFN-gamma, and enhances S-phase exit after thymineless stress, possibly via interaction with CDK-cyclin complexes. PMID:15342418

  18. The automatic surveillance, tracking, and imaging program. User manual

    NASA Astrophysics Data System (ADS)

    Szozda, Joe A.

    1989-03-01

    The automatic surveillance, tracking and imaging program (ASTIP) is a phased-array radar system which carries out surveillance of a designated field of view, and acquires and tracks multiple targets in its surveillance space. The user manual provides a detailed description of the device and file preparations that must be completed before ASTIP is run. The device and file preparations are summarized as an acquisition of resources list for quick reference by operators familiar with ASTIP. A detailed explanation of the preparations are presented in subsequent sections of the user manual. Each option in the menu-driven operator interface is discussed in detail. Diagrams of the ASTIP menus are located in the appendices. The error condition section explains the errors that are typically encountered and provides possible solutions to each of the problems. Finally, the procedures required to maintain the ASTIP software are explained in the building ASTIP section of the user manual.

  19. The teaching of computer programming and digital image processing in radiography.

    PubMed

    Allan, G L; Zylinski, J

    1998-06-01

    The increased use of digital processing techniques in Medical Radiations imaging modalities, along with the rapid advance in information technology has resulted in a significant change in the delivery of radiographic teaching programs. This paper details a methodology used to concurrently educate radiographers in both computer programming and image processing. The students learn to program in visual basic applications (VBA), and the programming skills are contextualised by requiring the students to write a digital subtraction angiography (DSA) package. Program code generation and image presentation interface is undertaken by the spreadsheet Microsoft Excel. The user-friendly nature of this common interface enables all students to readily begin program creation. The teaching of programming and image processing skills by this method may be readily generalised to other vocational fields where digital image manipulation is a professional requirement. PMID:9726504

  20. What Can the Community Involvement Program Tell Us about Alumni Giving at the University of the Pacific

    ERIC Educational Resources Information Center

    Ruiz-Huston, Ines Marta

    2010-01-01

    The purpose of this research is to analyze characteristics and motivators among alumni of the Community Involvement Program (CIP) for donating to the University of the Pacific. The research questions were: (1) what are the characteristics and motivators of CIP alumni for donating to the University of the Pacific? (2) do the characteristics and…

  1. Mesopause Horizontal wind estimates based on AIM CIPS polar mesospheric cloud pattern matching

    NASA Astrophysics Data System (ADS)

    Rong, P.; Yue, J.; Russell, J. M.; Gong, J.; Wu, D. L.; Randall, C. E.

    2013-12-01

    A cloud pattern matching approach is used to estimate horizontal winds in the mesopause region using Polar Mesospheric Cloud (PMC) albedo data measured by the Cloud Imaging and Particle Size instrument on the AIM satellite. Measurements for all 15 orbits per day throughout July 2007 are used to achieve statistical significance. For each orbit, eighteen out of the twenty-seven scenes are used for the pattern matching operation. Some scenes at the lower latitudes are not included because there is barely any cloud coverage for these scenes. The frame-size chosen is about 12 degrees in longitude and 3 degrees in latitude. There is no strict criterion in choosing the frame size since PMCs are widespread in the polar region and most local patterns do not have a clearly defined boundary. The frame moves at a step of 1/6th of the frame size in both the longitudinal and latitudinal directions to achieve as many 'snap-shots' as possible. A 70% correlation is used as a criterion to define an acceptable match between two patterns at two time frames; in this case the time difference is about 3.6 minutes that spans every 5 'bowtie' scenes. A 70% criterion appears weak if the chosen pattern is expected to act like a tracer. It is known that PMC brightness varies rapidly with a changing temperature and water vapor environment or changing nucleation conditions, especially on smaller spatial scales; therefore PMC patterns are not ideal tracers. Nevertheless, within a short time span such as 3.6 minutes a 70% correlation is sufficient to identify two cloud patterns that come from the same source region, although the two patterns may exhibit a significant difference in the actual brightness. Analysis of a large number of matched cloud patterns indicates that over the 3.6-minute time span about 70% of the patterns remain in the same locations. Given the 25-km2 horizontal resolution of CIPS data, this suggests that the overall magnitude of horizontal wind at PMC altitudes (~80-87 km) in

  2. Draft Genome Sequence of the Butyric Acid Producer Clostridium tyrobutyricum Strain CIP I-776 (IFP923)

    PubMed Central

    Clément, Benjamin; Lopes Ferreira, Nicolas

    2016-01-01

    Here, we report the draft genome sequence of Clostridium tyrobutyricum CIP I-776 (IFP923), an efficient producer of butyric acid. The genome consists of a single chromosome of 3.19 Mb and provides useful data concerning the metabolic capacities of the strain. PMID:26941139

  3. Structure of the catalytic domain of glucuronoyl esterase Cip2 from Hypocrea jecorina

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The structure of the catalytic domain of glucuronoyl esterase Cip2 from the fungus Hypocrea jecorina was determined at a resolution of 1.9 Angstroms. This is the first structure of the newly established carbohydrate esterase family 15. The structure has revealed the residues Ser278–His411–Glu301 pre...

  4. Interaction between the endoglucanase CelA and the scaffolding protein CipC of the Clostridium cellulolyticum cellulosome.

    PubMed Central

    Pagès, S; Belaich, A; Tardif, C; Reverbel-Leroy, C; Gaudin, C; Belaich, J P

    1996-01-01

    The 5' end of the cipC gene, coding for the N-terminal part of CipC, the scaffolding protein of Clostridium cellulolyticum ATCC 35319, was cloned and sequenced. It encodes a 586-amino-acid peptide, including several domains: a cellulose-binding domain, a hydrophilic domain, and two hydrophobic domains (cohesin domains). Sequence alignments showed that the N terminus of CipC and CbpA of C. cellulovorans ATCC 35296 have the same organization. The mini-CipC polypeptide, containing a cellulose-binding domain, hydrophilic domain 1, and cohesin domain 1, was overexpressed in Escherichia coli and purified. The interaction between endoglucanase CelA, with (CelA2) and without (CelA3) the characteristic clostridial C-terminal domain called the duplicated-segment or dockerin domain, and the mini-CipC polypeptide was monitored by two different methods: the interaction Western blotting (immunoblotting) method and binding assays with biotin-labeled protein. Among the various forms of CelA (CelA2, CelA3, and an intermediary form containing only part of the duplicated segment), only CelA2 was found to interact with cohesin domain 1 of CipC. The apparent equilibrium dissociation constant of the CelA2-mini-CipC complex was 7 x 10(-9)M, which indicates that there exists a high affinity between these two proteins. PMID:8636029

  5. CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis.

    PubMed

    Cerqueira, Otto L D; Truesdell, Peter; Baldassarre, Tomas; Vilella-Arias, Santiago A; Watt, Kathleen; Meens, Jalna; Chander, Harish; Osório, Cynthia A B; Soares, Fernando A; Reis, Eduardo M; Craig, Andrew W B

    2015-04-20

    Signaling via epidermal growth factor receptor (EGFR) and Src kinase pathways promote triple-negative breast cancer (TNBC) cell invasion and tumor metastasis. Here, we address the role of Cdc42-interacting protein-4 (CIP4) in TNBC metastasis in vivo, and profile CIP4 expression in human breast cancer patients. In human TNBC cells, CIP4 knock-down (KD) led to less sustained activation of Erk kinase and impaired cell motility compared to control cells. This correlated with significant defects in 3D invasion of surrounding extracellular matrix by CIP4 KD TNBC cells when grown as spheroid colonies. In mammary orthotopic xenograft assays using both human TNBC cells (MDA-MB-231, HCC 1806) and rat MTLn3 cells, CIP4 silencing had no overt effect on tumor growth, but significantly reduced the incidence of lung metastases in each tumor model. In human invasive breast cancers, high CIP4 levels was significantly associated with high tumor stage, TNBC and HER2 subtypes, and risk of progression to metastatic disease. Together, these results implicate CIP4 in promoting metastasis in TNBCs. PMID:25823823

  6. Applications review for a Space Program Imaging Radar (SPIR)

    NASA Technical Reports Server (NTRS)

    Simonett, D. S.

    1976-01-01

    The needs, applications, user support, research, and theoretical studies of imaging radar are reviewed. The applications of radar in water resources, minerals and petroleum exploration, vegetation resources, ocean radar imaging, and cartography are discussed. The advantages of space imaging radar are presented, and it is recommended that imaging radar be placed on the space shuttle.

  7. A Program To Promote Positive Body Image: A 1-Year Follow-Up Evaluation.

    ERIC Educational Resources Information Center

    McVey, Gail L.; Davis, Ron

    2002-01-01

    Evaluated the effectiveness of a program designed to promote body image satisfaction and prevent eating problems in young adolescent girls over a 1-year period. Found no program effect. Found instead, significant increases in body image satisfaction and decreases in eating problem scores over time for participants in both the prevention and…

  8. LIVA : a data reduction program for line-imaging ORVIS measurements.

    SciTech Connect

    Ao, Tommy

    2009-06-01

    LIVA (Line-Imaging Velocimetry Analysis) is a program for reducing data of a line-imaging optically recording velocity interferometer system (ORVIS) diagnostic. LIVA uses the Fourier transform method to extract phase information from recorded streak camera images. The extracted phase shift is used to infer target velocity as a function of space and time. The program can be run in any current version of MATLAB (2008a or later) or as a Windows XP executable.

  9. Role of “oncogenic nexus” of CIP2A in breast oncogenesis: how does it work?

    PubMed Central

    De, Pradip; Carlson, Jennifer H; Leyland-Jones, Brian; Dey, Nandini

    2015-01-01

    The CIP2A gene is an oncogene associated with solid and hematologic malignancies [1]. CIP2A protein is an oncoprotein and a potential cancer therapy target [2]. Literature shows that CIP2A inhibits the tumor suppressor protein PP2A [3] which downregulates phophorylation of AKT, a hallmark of cancers [4] and stabilizes the proto-oncogene, c-MYC in tumor cells [5], the comprehensive action of CIP2A and its functional interaction(s) with other oncoproteins and tumor suppressors is not clearly established. Recently we tried to put forward a contextual mode-of-action of CIP2A protein in a review which proposed that CIP2A influences oncogenesis via an “oncogenic nexus” [1]. In this review we critically evaluated the potential relevance of the mode-of-action of the “oncogenic nexus” of CIP2A in breast carcinogenesis and appraised the role of this nexus in different PAM50 luminal A, PAM50 luminal B, PAM50 HER2-enriched and PAM50 basal BC. This review has a novel approach. Here we have not only compiled and discussed the latest developments in this field but also presented data obtained from c-BioPortal and STRING10 in order to substantiate our view regarding the mode-of-action of the “oncogenic nexus” of CIP2A. We functionally correlated alterations of genes pertaining to the “oncogenic nexus” of CIP2A with protein-protein interactions between the different components of the nexus including (1) subunits of PP2A, (2) multiple transcription factors including MYC oncogene and (3) components of the PI3K-mTOR and the MAPK-ERK oncogenic pathways. Using these proteins as “input” to STRING10 we studied the association, Action view, at the highest Confidence level. OncoPrints (c-BioPortal) showed alterations (%) of regulatory subunits genes of PP2A (PPP2R1A and PPP2R1B) along with alterations of CIP2A in breast invasive carcinoma (TCGA, Nature 2012 & TCGA, Provisional). Similar genetic alterations of PP2A were also observed in samples of breast tumors at our

  10. The sonographic digital portfolio: a longitudinal ultrasound image tracking program

    PubMed Central

    2012-01-01

    Background Ultrasonography (US) at the medical student level is developing. As clinical skills and simulation centers expand, US equipment miniaturizes, and more students are exposed to ultrasound; a digital portfolio comprised of US images and videos may be useful in demonstrating experience and possibly competency. Methods Medical students participated in US curricula consisting of didactics and hands-on training. From 1 July 2006 to 30 June 2008, student images and videos were saved. Total images and videos were evaluated and catalogued. Results A total of 10,074 images and 1,227 videos were saved during the 2-year period. For the academic year 2006 to 2007, 159 medical students obtained 3,641 of the images (84.9%) and 270 of the videos (86.0%). First year students obtained 778 images and 20 videos; second year students, 1,174 images and 64 videos; third year students, 211 images and 20 videos; and fourth year students, 1,478 images and 166 videos. For the academic year 2007 to 2008, 222 medical students obtained 4,340 images (75%) and 619 videos (67.8%). First year students obtained 624 images and 109 videos; second year students, 555 images and 81 videos; third year students, 132 images and 14 videos; and fourth year students, 3,029 images and 415 videos. Conclusions The ultrasound digital portfolio allows medical students to collate and document their ultrasound experience. Currently, there is no requirement for ultrasound training, documentation of competency, or minimum numbers of US exams for medical education. The ultrasound digital portfolio may be a useful tool in documenting ultrasound proficiency. PMID:22871130

  11. Study of the Career Intern Program. Task D Final Report, Volume I. A Comparison of Implementation Issues in YEDPA Programs.

    ERIC Educational Resources Information Center

    Stromquist, Nelly P.

    Five Youth Employment and Demonstration Program Act (YEDPA) programs are compared with the Career Intern Program (CIP) (an alternative high school program aiming to prepare dropouts, and those likely to abandon school, for employment) in terms of emphasizing issues related to program implementation. The YEDPA programs selected for comparison upon…

  12. NASA Sea Ice Validation Program for the Defense Meteorological Satellite Program Special Sensor Microwave Imager

    NASA Technical Reports Server (NTRS)

    Cavalieri, Donald J. (Editor); Crawford, John P.; Drinkwater, Mark R.; Emery, William J.; Eppler, Duane T.; Farmer, L. Dennis; Fowler, Charles W.; Goodberlet, Mark; Jentz, Robert R.; Milman, Andrew

    1992-01-01

    The history of the program is described along with the SSM/I sensor, including its calibration and geolocation correction procedures used by NASA, SSM/I data flow, and the NASA program to distribute polar gridded SSM/I radiances and sea ice concentrations (SIC) on CD-ROMs. Following a discussion of the NASA algorithm used to convert SSM/I radiances to SICs, results of 95 SSM/I-MSS Landsat IC comparisons for regions in both the Arctic and the Antarctic are presented. The Landsat comparisons show that the overall algorithm accuracy under winter conditions is 7 pct. on average with 4 pct. negative bias. Next, high resolution active and passive microwave image mosaics from coordinated NASA and Navy aircraft underflights over regions of the Beaufort and Chukchi seas in March 1988 were used to show that the algorithm multiyear IC accuracy is 11 pct. on average with a positive bias of 12 pct. Ice edge crossings of the Bering Sea by the NASA DC-8 aircraft were used to show that the SSM/I 15 pct. ice concentration contour corresponds best to the location of the initial bands at the ice edge. Finally, a summary of results and recommendations for improving the SIC retrievals from spaceborne radiometers are provided.

  13. Supporting image algebra in the Matlab programming language for compression research

    NASA Astrophysics Data System (ADS)

    Schmalz, Mark S.; Ritter, Gerhard X.; Wilson, Joseph N.; Hayden, Eric T.

    2009-08-01

    Image algebra is a rigorous, concise notation that unifies linear and nonlinear mathematics in the image domain. Image algebra was developed under DARPA and US Air Force sponsorship at University of Florida for over 15 years beginning in 1984. Image algebra has been implemented in a variety of programming languages designed specifically to support the development of image processing and computer vision programs. The University of Florida has been associated with implementations supporting the languages FORTRAN, Ada, Lisp, and C++. The latter implementation involved the implementation of a class library, iac++, that supported image algebra programming in C++. Since image processing and computer vision are generally performed with operands that are array-based, the MatlabTM programming language is ideal for implementing the common subset of image algebra. Objects include sets and set operations, images and operations on images, as well as templates and image-template convolution operations. This implementation has been found to be useful for research in data, image, and video compression, as described herein. Due to the widespread acceptance of the Matlab programming language in the computing community, this new implementation offers exciting possibilities for supporting a large group of users. The control over an object's computational resources provided to the algorithm designer by Matlab means that the image algebra Matlab (IAM) library can employ versatile representations for the operands and operations of the algebra. In this paper, we first outline the purpose and structure of image algebra, then present IAM notation in relationship to the preceding (IAC++) implementation. We then provide examples to show how IAM is more convenient and more readily supports efficient algorithm development. Additionally, we show how image algebra and IAM can be employed in compression algorithm development and analysis.

  14. Functional Heterologous Expression of an Engineered Full Length CipA from Clostridium thermocellum in Thermoanaerobacterium saccharolyticum

    SciTech Connect

    Currie, Devin; Herring, Christopher; Guss, Adam M; Olson, Daniel G.; Hogsett, David; Lynd, Lee R

    2013-01-01

    BACKGROUND: Cellulose is highly recalcitrant and thus requires a specialized suite of enzymes to solubilize it into fermentable sugars. In C. thermocellum, these extracellular enzymes are present as a highly active multi-component system known as the cellulosome. This study explores the expression of a critical C. thermocellum cellulosomal component in T. saccharolyticum as a step toward creating a thermophilic bacterium capable of consolidated bioprocessing by employing heterologously expressed cellulosomes. RESULTS: We developed an inducible promoter system based on the native T. saccharolyticum xynA promoter, which was shown to be induced by xylan and xylose. The promoter was used to express the cellulosomal component cipA*, an engineered form of the wild-type cipA from C. thermocellum. Expression and localization to the supernatant were both verified for CipA*. When a cipA mutant C. thermocellum strain was cultured with a CipA*-expressing T. saccharolyticum strain, hydrolysis and fermentation of 10 grams per liter SigmaCell 101, a highly crystalline cellulose, were observed. This trans-species complementation of a cipA deletion demonstrated the ability for CipA* to assemble a functional cellulosome. CONCLUSION: This study is the first example of an engineered thermophile heterologously expressing a structural component of a cellulosome. To achieve this goal we developed and tested an inducible promoter for controlled expression in T. saccharolyticum as well as a synthetic cipA. In addition, we demonstrate a high degree of hydrolysis (up to 93%) on microcrystalline cellulose.

  15. Overexpression of CIP2A is an independent prognostic indicator in nasopharyngeal carcinoma and its depletion suppresses cell proliferation and tumor growth

    PubMed Central

    2014-01-01

    Background Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein that acts as a prognostic marker for several human malignancies. In this study, we investigated the clinical significance of CIP2A and its function in nasopharyngeal carcinoma (NPC). Methods Quantitative RT-PCR, western blot, and immunohistochemistry analyses were used to quantify CIP2A expression in NPC cell lines and clinical samples. Kaplan-Meier curves were used to estimate the association between CIP2A expression and patient survival. The functional role of CIP2A in NPC cell lines was evaluated by small interfering RNA-mediated depletion of the protein followed by analyses of cell proliferation and xenograft growth. Results CIP2A levels were upregulated in NPC cell lines and clinical samples at both the mRNA and protein levels (P < 0.01). Patients with high CIP2A expression had poorer overall survival (HR, 1.98; 95% CI, 1.16-3.34; P = 0.01) and poorer disease-free survival (HR, 1.68; 95% CI, 1.07-2.62; P = 0.02) rates than patients with low CIP2A expression. In addition, CIP2A expression status was an independent prognostic indicator for NPC patients. The depletion of CIP2A expression inhibited c-Myc protein expression in NPC cell lines, suppressed cell viability, colony formation, and anchorage-independent growth in vitro, and inhibited xenograft tumor growth in vivo. Conclusions Our data demonstrate that high CIP2A expression in patients was associated with poor survival in NPC, and depletion of CIP2A expression inhibited NPC cell proliferation and tumor growth. Thus, these results warrant further investigation of CIP2A as a novel therapeutic target for the treatment of NPC. PMID:24884612

  16. Assessment of diabetic teleretinal imaging program at the Portland Department of Veterans Affairs Medical Center.

    PubMed

    Tsan, Grace L; Hoban, Keely L; Jun, Weon; Riedel, Kevin J; Pedersen, Amy L; Hayes, John

    2015-01-01

    We conducted a retrospective chart review of 200 diabetic patients who had teleretinal imaging performed between January 1, 2010, and January 1, 2011, at Portland Department of Veterans Affairs (VA) Medical Center outpatient clinics to assess the effectiveness of the diabetic teleretinal imaging program. Twenty patients (10%) had diabetic retinopathy. Ninety percent of the available teleretinal imaging studies were of adequate quality for interpretation. In accordance with local VA policy at that time, all teleretinal imaging patients should have been referred for a dilated retinal examination the following year. Image readers referred 97.5% of the patients to eye clinics for subsequent eye examinations, but the imagers scheduled appointments for only 80% of these patients. The redundancy rate, i.e., patients who had an eye examination within the past 6 mo, was 11%; the duplicate recall rate, i.e., patients who had a second teleretinal imaging performed within 1 yr of the eye examination, was 37%. Rates of timely diabetic eye examinations at clinics with teleretinal imaging programs, particularly when teleretinal imaging and eye clinics were colocated at the same community-based outpatient clinic, were higher than those without a teleretinal imaging program. We concluded that the Portland VA Medical Center's teleretinal imaging program was successful in increasing the screening rate for diabetic retinopathy. PMID:26230276

  17. A COUPLED TH/NEUTRONICS/CRUD FRAMEWORK IN PREDICTION OF CIPS PHENOMENON

    SciTech Connect

    Ling Zou; Hongbin Zhang; Jess Gehin; Brendan Kochunas

    2012-04-01

    A coupled TH/Neutronics/CRUD framework, which is able to simulate the CRUD deposits impact on CIPS phenomenon, was described in this paper. This framework includes the coupling among three essential physics, thermal-hydraulics, CRUD and neutronics. The overall framework was implemented by using the CFD software STAR-CCM+, developing CRUD codes, and using the neutronics code DeCART. The coupling was implemented by exchanging data between softwares using intermediate exchange files. A typical 3 by 3 PWR fuel pin problem was solved under this framework. The problem was solved in a 12 months length period of time. Time-dependent solutions were provided, including CRUD deposits inventory and their distributions on fuels, boron hideout amount inside CRUD deposits, as well as power shape changing over time. The results clearly showed the power shape suppression in regions where CRUD deposits exist, which is a strong indication of CIPS phenomenon.

  18. FOR Allocation to Distribution Systems based on Credible Improvement Potential (CIP)

    NASA Astrophysics Data System (ADS)

    Tiwary, Aditya; Arya, L. D.; Arya, Rajesh; Choube, S. C.

    2016-06-01

    This paper describes an algorithm for forced outage rate (FOR) allocation to each section of an electrical distribution system subject to satisfaction of reliability constraints at each load point. These constraints include threshold values of basic reliability indices, for example, failure rate, interruption duration and interruption duration per year at load points. Component improvement potential measure has been used for FOR allocation. Component with greatest magnitude of credible improvement potential (CIP) measure is selected for improving reliability performance. The approach adopted is a monovariable method where one component is selected for FOR allocation and in the next iteration another component is selected for FOR allocation based on the magnitude of CIP. The developed algorithm is implemented on sample radial distribution system.

  19. Higher-order schemes with CIP method and adaptive Soroban grid towards mesh-free scheme

    NASA Astrophysics Data System (ADS)

    Yabe, Takashi; Mizoe, Hiroki; Takizawa, Kenji; Moriki, Hiroshi; Im, Hyo-Nam; Ogata, Youichi

    2004-02-01

    A new class of body-fitted grid system that can keep the third-order accuracy in time and space is proposed with the help of the CIP (constrained interpolation profile/cubic interpolated propagation) method. The grid system consists of the straight lines and grid points moving along these lines like abacus - Soroban in Japanese. The length of each line and the number of grid points in each line can be different. The CIP scheme is suitable to this mesh system and the calculation of large CFL (>10) at locally refined mesh is easily performed. Mesh generation and searching of upstream departure point are very simple and almost mesh-free treatment is possible. Adaptive grid movement and local mesh refinement are demonstrated.

  20. Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): An oncoprotein with many hands

    PubMed Central

    De, Pradip; Carlson, Jennifer; Leyland-Jones, Brian; Dey, Nandini

    2014-01-01

    Oncoprotein CIP2A a Cancerous Inhibitor of PP2A forms an “oncogenic nexus” by virtue of its control on PP2A and MYC stabilization in cancer cells. The expression and prognostic function of CIP2A in different solid tumors including colorectal carcinoma, head & neck cancers, gastric cancers, lung carcinoma, cholangiocarcinoma, esophageal cancers, pancreatic carcinoma, brain cancers, breast carcinoma, bladder cancers, ovarian carcinoma, renal cell carcinomas, tongue cancers, cervical carcinoma, prostate cancers, and oral carcinoma as well as a number of hematological malignancies are just beginning to emerge. Herein, we reviewed the recent progress in our understanding of (1) how an “oncogenic nexus” of CIP2A participates in the tumorigenic transformation of cells and (2) how we can prospect/view the clinical relevance of CIP2A in the context of cancer therapy. The review will try to understand the role of CIP2A (a) as a biomarker in cancers and evaluate the prognostic value of CIP2A in different cancers (b) as a therapeutic target in cancers and (c) in drug response and developing chemo-resistance in cancers. PMID:25015035

  1. Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): an oncoprotein with many hands.

    PubMed

    De, Pradip; Carlson, Jennifer; Leyland-Jones, Brian; Dey, Nandini

    2014-07-15

    Oncoprotein CIP2A a Cancerous Inhibitor of PP2A forms an "oncogenic nexus" by virtue of its control on PP2A and MYC stabilization in cancer cells. The expression and prognostic function of CIP2A in different solid tumors including colorectal carcinoma, head and neck cancers, gastric cancers, lung carcinoma, cholangiocarcinoma, esophageal cancers, pancreatic carcinoma, brain cancers, breast carcinoma, bladder cancers, ovarian carcinoma, renal cell carcinomas, tongue cancers, cervical carcinoma, prostate cancers, and oral carcinoma as well as a number of hematological malignancies are just beginning to emerge. Herein, we reviewed the recent progress in our understanding of (1) how an "oncogenic nexus" of CIP2A participates in the tumorigenic transformation of cells and (2) how we can prospect/view the clinical relevance of CIP2A in the context of cancer therapy. The review will try to understand the role of CIP2A (a) as a biomarker in cancers and evaluate the prognostic value of CIP2A in different cancers (b) as a therapeutic target in cancers and (c) in drug response and developing chemo-resistance in cancers. PMID:25015035

  2. The AFGL image reconstruction program 2 speckle interferometry

    NASA Astrophysics Data System (ADS)

    Worden, S. P.; Hege, E. K.; Hubbard, E. N.; Woolf, N. J.; Strittmatter, P. A.

    1981-12-01

    Recent work indicates that large-telescope, optics-limited images are recoverable for objects as faint as +15 stellar magnitudes using a technique called speckle interferometry. This report presents a review of speckle interferometry, including current status and results. Section 2 provides a background of the Fourier mathematics used in image processing and optical systems. Section 3 describes how the atmosphere degrades astronomical images and how speckle interferometry has been used to recover high-resolution detail. Section 4 describes new work to recover actual optics-limited images, and compares active optics systems with speckle interferometry.

  3. Electromagnetic and absorbing property of CIPs/resin composite using the 3D forming process

    NASA Astrophysics Data System (ADS)

    Xu, Yonggang; Liang, Zichang; Wang, Xiaobing; Yuan, Liming; Li, Xinghao

    2016-08-01

    The absorbing composite filled with the flaky carbonyl iron particles (CIPs) were prepared using a three-dimensional (3D) forming process, in which the forming powder was fabricated using a milling process. The surface morphology was characterized by the scanning electron microscopy, the static magnetic property was evaluated on a vibrating sample magnetometer, and X-ray diffraction (XRD) patterns were done to analyze the particle crystal grain structure. The complex permittivity and permeability were measured using a vector network analyzer in the frequency range of 4-18 GHz. With the variable thickness was set, the reflection loss (RL) was simulated to analyze the absorbing property of the composite. The results showed that the forming powder was uniformly dispersed in the absorber, and the saturation magnetization and the grain structure of the CIPs in the forming powder nearly did not change in the milling process. With the same volume content CIPs added, the average permittivity and the imaginary permeability of the samples added the powder was smaller than the directly mixing sample due to the aggregation effect. The RL results showed that the absorbing composites using the 3D forming process with thickness 6 or 8 mm had an better absorbing property (minimum RL -13.58 and -21.85 dB) in 4-18 GHz.

  4. Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development

    PubMed Central

    González-Loyola, Alejandra; Fernández-Miranda, Gonzalo; Trakala, Marianna; Partida, David; Samejima, Kumiko; Ogawa, Hiromi; Cañamero, Marta; de Martino, Alba; Martínez-Ramírez, Ángel; de Cárcer, Guillermo; Pérez de Castro, Ignacio; Earnshaw, William C.

    2015-01-01

    Aurora kinase B, one of the three members of the mammalian Aurora kinase family, is the catalytic component of the chromosomal passenger complex, an essential regulator of chromosome segregation in mitosis. Aurora B is overexpressed in human tumors although whether this kinase may function as an oncogene in vivo is not established. Here, we report a new mouse model in which expression of the endogenous Aurkb locus can be induced in vitro and in vivo. Overexpression of Aurora B in cultured cells induces defective chromosome segregation and aneuploidy. Long-term overexpression of Aurora B in vivo results in aneuploidy and the development of multiple spontaneous tumors in adult mice, including a high incidence of lymphomas. Overexpression of Aurora B also results in a reduced DNA damage response and decreased levels of the p53 target p21Cip1 in vitro and in vivo, in line with an inverse correlation between Aurora B and p21Cip1 expression in human leukemias. Thus, overexpression of Aurora B may contribute to tumor formation not only by inducing chromosomal instability but also by suppressing the function of the cell cycle inhibitor p21Cip1. PMID:26240282

  5. The image/poetry education and public outreach program

    NASA Astrophysics Data System (ADS)

    Odenwald, Sten F.; Taylor, William W. L.; Reiff, Patricia H.

    2000-01-01

    Education and public outreach are viewed by NASA as significant undertakings for all of its space missions. The IMAGE satellite is one of the first missions to explicitly include `E&PO' in its original proposal to NASA in 1996. We will discuss what IMAGE has accomplished in this area to date, and what new activities it will conduct following a successful launch.

  6. Planetary instrument definition and development program: 'Miniature Monochromatic Imager'

    NASA Technical Reports Server (NTRS)

    Broadfoot, A. L.

    1991-01-01

    The miniature monochromatic imager (MMI) development work became the basis for the preparation of several instruments which were built and flown on the shuttle STS-39 as well as being used in ground based experiments. The following subject areas are covered: (1) applications of the ICCD to airglow and auroral measurements and (2) a panchromatic spectrograph with supporting monochromatic imagers.

  7. CIP's Eighth Annual Educational Software Contest: The Winners.

    ERIC Educational Resources Information Center

    Donnelly, Denis

    1997-01-01

    Announces the winners of an annual software contest for innovative software in physics education. Winning entries include an application to help students visualize the origin of energy bands in a solid, a package on the radioastronomy of pulsars, and a school-level science simulation program. Also includes student winners, honorable mentions,…

  8. Mississippi Curriculum Framework for Business and Office and Related Technology Cluster. Office Systems Technology (CIP: 52.0401--Administrative Assistant/Secretarial). Accounting Technology (CIP: 52.0302). Medical Office Technology (CIP: 52.0404--Medical Admin. Asst./Secretarial). Microcomputer Technology (CIP: 52.0490). Court Reporting Technology (CIP: 52.0405). Paralegal Technology (CIP: Paralegal/Legal Assistant).

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for four programs in the postsecondary-level business and office cluster (office systems, accounting, medical office, and microcomputer technologies) and two programs in the legal cluster (court reporting and paralegal…

  9. Fast imaging applications in the Nuclear Test Program

    SciTech Connect

    Lear, R.

    1983-10-14

    Applications of fast imaging employ both streak cameras and fast framing techniques. Image intensifier tubes are gated to provide fast two-dimensional shutters of 2 to 3 ns duration with shatter ratios of greater than 10/sup 6/ and resolution greater than 10/sup 4/ pixels. Shutters of less than 1 ns have been achieved with experimental tubes. Characterization data demonstrate the importance of tube and pulser design. Streak cameras are used to simultaneously record temporal and intensity information from up to 200 spatial points. Streak cameras are combined with remote readout for downhole uses and are coupled to fiber optic cables for uphole uses. Optical wavelength multiplexing is being studied as a means of compressing additional image data onto optical fibers. Performance data demonstrate trade-offs between image resolution and system sensitivity.

  10. NIH Roadmap & the Common Fund - Cancer Imaging Program

    Cancer.gov

    The NIH Roadmap for Medical Research is a series of high impact, trans-NIH programs supported by the NIH Common Fund. These programs address challenges that are priorities for the NIH and medical research but are issues that require the cooperation of more than one NIH institute to address.

  11. Genome image programs: visualization and interpretation of Escherichia coli microarray experiments.

    PubMed Central

    Zimmer, Daniel P; Paliy, Oleg; Thomas, Brian; Gyaneshwar, Prasad; Kustu, Sydney

    2004-01-01

    We have developed programs to facilitate analysis of microarray data in Escherichia coli. They fall into two categories: manipulation of microarray images and identification of known biological relationships among lists of genes. A program in the first category arranges spots from glass-slide DNA microarrays according to their position in the E. coli genome and displays them compactly in genome order. The resulting genome image is presented in a web browser with an image map that allows the user to identify genes in the reordered image. Another program in the first category aligns genome images from two or more experiments. These images assist in visualizing regions of the genome with common transcriptional control. Such regions include multigene operons and clusters of operons, which are easily identified as strings of adjacent, similarly colored spots. The images are also useful for assessing the overall quality of experiments. The second category of programs includes a database and a number of tools for displaying biological information about many E. coli genes simultaneously rather than one gene at a time, which facilitates identifying relationships among them. These programs have accelerated and enhanced our interpretation of results from E. coli DNA microarray experiments. Examples are given. PMID:15342544

  12. Going the Distance: Taking a Diagnostic Imaging Program to Frontier and Rural Oregon

    ERIC Educational Resources Information Center

    Malosh, Ann; Mallory, Stacy; Olson, Marcene

    2009-01-01

    The Grow Your Own diagnostic imaging program is a public/private collaborative venture involving the efforts of an array of community colleges, employers, workforce, and educational partners throughout Oregon. This statewide Community College Partnership delivers diagnostic imaging education to Oregon's rural communities via distributed learning…

  13. Interactions of ciprofloxacin (CIP), titanium dioxide (TiO2) nanoparticles and natural organic matter (NOM) in aqueous suspensions.

    PubMed

    Fries, Elke; Crouzet, Catherine; Michel, Caroline; Togola, Anne

    2016-09-01

    The aim of the present study was to investigate interactions of the antibiotic ciprofloxacin (CIP), titanium dioxide nanoparticles (TiO2 NP) and natural organic matter (NOM) in aqueous suspensions. The mean hydrodynamic diameter of particles of TiO2 NP and NOM in the suspensions ranged from 113 to 255nm. During batch experiments the radioactivity resulting from (14)CIP was determined in the filtrate (filter pore size 100nm) by scintillation measurements. Up to 72h, no significant sorption of NOM to TiO2 NP was observed at a TiO2 NP concentration of 5mg/L. When the concentration of TiO2 NP was increased to 500mg/L, a small amount of NOM of 9.5%±0.6% was sorbed at 72h. The low sorption affinity of NOM on TiO2 NP surfaces could be explained by the negative charge of both components in alkaline media or by the low hydrophobicity of the NOM contents. At a TiO2 NP concentration of 5mgL(-1), the sorption of CIP on TiO2 NP was insignificant (TiO2 NP/CIP ratio: 10). When the TiO2 NP/CIP ratio was increased to 1000, a significant amount of 53.6%±7.2% of CIP was sorbed on TiO2 NP under equilibrium conditions at 64h. In alkaline media, CIP is present mainly as zwitterions which have an affinity to sorb on negatively charged TiO2 NP surfaces. The sorption of CIP on TiO2 NP in the range of TiO2 NP concentrations currently estimated for municipal wastewater treatment plants is estimated to be rather low. The Freundlich sorption coefficients (KF) in the presence of NOM of 2167L(n)mgmg(-n)kg(-1) was about 10 times lower than in the absence of NOM. This is an indication that the particle fraction of NOM<100nm could play a role as a carrier for ionic organic micro-pollutants as CIP. PMID:26765511

  14. Applications notice for participation in the LANDSAT-D image data quality analysis program

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The applications notice for the LANDSAT 4 image data quality analysis program is presented. The objectives of the program are to qualify LANDSAT 4 sensor and systems performance from a user applications point of view, and to identify any malfunctions that may impact data applications. Guidelines for preparing proposals and background information are provided.

  15. PIXTOOLS - 13 PROGRAMS AND A LIBRARY THAT OPERATE ON BITMAP IMAGE FILES

    NASA Technical Reports Server (NTRS)

    Choi, D.

    1994-01-01

    PIXTOOLS is a package for the Silicon Graphics IRIS consisting of thirteen programs plus a library for operating on bitmap images. The image data structure is referred to as a PIXIMAGE. The programs allow the IRIS user to create and edit, perform screen saves, resize, and capture high-resolution images from the Sharp JX450 scanner. Images can be output to the QMS laser printer, the Tektronix 4693 color thermal printer, and the Matrix QCRZ film recorder. Additionally, PIX format images can be converted to SGI image format (and vice versa) or converted to PostScript format. PIX or SGI format images can be converted to ".ras" files which can be read by the "rasp" routine in the PLOT3D/AMES program (available from COSMIC), and ".ras" files can be converted to PIX files. Eleven of the programs print information and read and write files while two, PIXSCAN and PIXEDIT, offer graphical interfaces. PIXEDIT uses the full IRIS screen as a drawing area and pop-up menus are available. The menus allow manipulation of images and background color, and saving the screen to a file. PIXSCAN is the user interface to the Sharp JX450 scanner. This program allows the user to do a preliminary scan of an image at low resolution, and then select an area to rescan in higher resolution into a file. PIXSCAN requires the user to have the "gpib" (IEEE 488) board and "libgpib.a" library from Silicon Graphics, Inc. User instructions for all the programs are provided in the form of UNIX on-line manual pages. The PIXTOOLS programs are written in C-Language for execution on SGI IRIS 4D series workstations running IRIX 3.2 or later. PIXEDIT (the largest program) requires 840K of main memory. The programs with graphical interfaces require that the IRIS have at least 24 bit planes. The program package is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format. A README file and UNIX man pages provide information regarding installation and use of the PIXTOOLS programs. A nine

  16. CIP4 coordinates with phospholipids and actin-associated proteins to localize to the protruding edge and produce actin ribs and veils.

    PubMed

    Saengsawang, Witchuda; Taylor, Kendra L; Lumbard, Derek C; Mitok, Kelly; Price, Amanda; Pietila, Lauren; Gomez, Timothy M; Dent, Erik W

    2013-06-01

    Cdc42-interacting protein 4 (CIP4), a member of the F-BAR family of proteins, plays important roles in a variety of cellular events by regulating both membrane and actin dynamics. In many cell types, CIP4 functions in vesicle formation, endocytosis and membrane tubulation. However, recent data indicate that CIP4 is also involved in protrusion in some cell types, including cancer cells (lamellipodia and invadopodia) and neurons (ribbed lamellipodia and veils). In neurons, CIP4 localizes specifically to extending protrusions and functions to limit neurite outgrowth early in development. The mechanism by which CIP4 localizes to the protruding edge membrane and induces lamellipodial/veil protrusion and actin rib formation is not known. Here, we show that CIP4 localization to the protruding edge of neurons is dependent on both the phospholipid content of the plasma membrane and the underlying organization of actin filaments. Inhibiting phosphatidylinositol (3,4,5)-trisphosphate (PIP3) production decreases CIP4 at the membrane. CIP4 localization to the protruding edge is also dependent on Rac1/WAVE1, rather than Cdc42/N-WASP. Capping actin filaments with low concentrations of cytochalasin D or by overexpressing capping protein dramatically decreases CIP4 at the protruding edge, whereas inactivating Arp2/3 drives CIP4 to the protruding edge. We also demonstrate that CIP4 dynamically colocalizes with Ena/VASP and DAAM1, two proteins known to induce unbranched actin filament arrays and play important roles in neuronal development. Together, this is the first study to show that the localization of an F-BAR protein depends on both actin filament architecture and phospholipids at the protruding edge of developing neurons. PMID:23572514

  17. The Crystal Structure of the Core Domain of a Cellulose Induced Protein (Cip1) from Hypocrea jecorina, at 1.5 Å Resolution

    PubMed Central

    Jacobson, Frida; Karkehabadi, Saeid; Hansson, Henrik; Goedegebuur, Frits; Wallace, Louise; Mitchinson, Colin; Piens, Kathleen; Stals, Ingeborg; Sandgren, Mats

    2013-01-01

    In an effort to characterise the whole transcriptome of the fungus Hypocrea jecorina, cDNA clones of this fungus were identified that encode for previously unknown proteins that are likely to function in biomass degradation. One of these newly identified proteins, found to be co-regulated with the major H. jecorina cellulases, is a protein that was denoted Cellulose induced protein 1 (Cip1). This protein consists of a glycoside hydrolase family 1 carbohydrate binding module connected via a linker region to a domain with yet unknown function. After cloning and expression of Cip1 in H. jecorina, the protein was purified and biochemically characterised with the aim of determining a potential enzymatic activity for the novel protein. No hydrolytic activity against any of the tested plant cell wall components was found. The proteolytic core domain of Cip1 was then crystallised, and the three-dimensional structure of this was determined to 1.5 Å resolution utilising sulphur single-wavelength anomalous dispersion phasing (sulphor-SAD). A calcium ion binding site was identified in a sequence conserved region of Cip1 and is also seen in other proteins with the same general fold as Cip1, such as many carbohydrate binding modules. The presence of this ion was found to have a structural role. The Cip1 structure was analysed and a structural homology search was performed to identify structurally related proteins. The two published structures with highest overall structural similarity to Cip1 found were two poly-lyases: CsGL, a glucuronan lyase from H. jecorina and vAL-1, an alginate lyase from the Chlorella virus. This indicates that Cip1 may be a lyase. However, initial trials did not detect significant lyase activity for Cip1. Cip1 is the first structure to be solved of the 23 currently known Cip1 sequential homologs (with a sequence identity cut-off of 25%), including both bacterial and fungal members. PMID:24039705

  18. Biomedical image analysis using Markov random fields & efficient linear programing.

    PubMed

    Komodakis, Nikos; Besbes, Ahmed; Glocker, Ben; Paragios, Nikos

    2009-01-01

    Computer-aided diagnosis through biomedical image analysis is increasingly considered in health sciences. This is due to the progress made on the acquisition side, as well as on the processing one. In vivo visualization of human tissues where one can determine both anatomical and functional information is now possible. The use of these images with efficient intelligent mathematical and processing tools allows the interpretation of the tissues state and facilitates the task of the physicians. Segmentation and registration are the two most fundamental tools in bioimaging. The first aims to provide automatic tools for organ delineation from images, while the second focuses on establishing correspondences between observations inter and intra subject and modalities. In this paper, we present some recent results towards a common formulation addressing these problems, called the Markov Random Fields. Such an approach is modular with respect to the application context, can be easily extended to deal with various modalities, provides guarantees on the optimality properties of the obtained solution and is computationally efficient. PMID:19963682

  19. Mindseye: a visual programming and modeling environment for imaging science

    NASA Astrophysics Data System (ADS)

    Carney, Thom

    1998-07-01

    Basic vision science research has reached the point that many investigators are now designing quantitative models of human visual function in areas such as, pattern discrimination, motion detection, optical flow, color discrimination, adaptation and stereopsis. These models have practical significance in their application to image compression technologies and as tools for evaluating image quality. We have been working on a vision modeling environment, called Mindseye, that is designed to simplify the implementation and testing of general purpose spatio- temporal models of human vision. Mindseye is an evolving general-purpose vision-modeling environment that embodies the general structures of the visual system and provides a set of modular tools within a flexible platform tailored to the needs of researchers. The environment employs a user- friendly graphics interface with on-line documentation that describes the functionality of the individual modules. Mindseye, while functional, is still research in progress. We are seeking input from the image compression and evaluation community as well as from the vision science community as to the potential utility of Mindseye, and how it might be enhanced to meet future needs.

  20. A new algorithm to reduce noise in microscopy images implemented with a simple program in python.

    PubMed

    Papini, Alessio

    2012-03-01

    All microscopical images contain noise, increasing when (e.g., transmission electron microscope or light microscope) approaching the resolution limit. Many methods are available to reduce noise. One of the most commonly used is image averaging. We propose here to use the mode of pixel values. Simple Python programs process a given number of images, recorded consecutively from the same subject. The programs calculate the mode of the pixel values in a given position (a, b). The result is a new image containing in (a, b) the mode of the values. Therefore, the final pixel value corresponds to that read in at least two of the pixels in position (a, b). The application of the program on a set of images obtained by applying salt and pepper noise and GIMP hurl noise with 10-90% standard deviation showed that the mode performs better than averaging with three-eight images. The data suggest that the mode would be more efficient (in the sense of a lower number of recorded images to process to reduce noise below a given limit) for lower number of total noisy pixels and high standard deviation (as impulse noise and salt and pepper noise), while averaging would be more efficient when the number of varying pixels is high, and the standard deviation is low, as in many cases of Gaussian noise affected images. The two methods may be used serially. PMID:21898664

  1. Program for PET image alignment: Effects on calculated differences in cerebral metabolic rates for glucose

    SciTech Connect

    Phillips, R.L.; London, E.D.; Links, J.M.; Cascella, N.G. )

    1990-12-01

    A program was developed to align positron emission tomography images from multiple studies on the same subject. The program allowed alignment of two images with a fineness of one-tenth the width of a pixel. The indications and effects of misalignment were assessed in eight subjects from a placebo-controlled double-blind crossover study on the effects of cocaine on regional cerebral metabolic rates for glucose. Visual examination of a difference image provided a sensitive and accurate tool for assessing image alignment. Image alignment within 2.8 mm was essential to reduce variability of measured cerebral metabolic rates for glucose. Misalignment by this amount introduced errors on the order of 20% in the computed metabolic rate for glucose. These errors propagate to the difference between metabolic rates for a subject measured in basal versus perturbed states.

  2. Programs Offered and Programs Completed at North Dakota Institutions of Postsecondary Education, July 1, 2008-June 30, 2009

    ERIC Educational Resources Information Center

    Schepp, Julie; Domagala, Anna

    2009-01-01

    This report provides information on degree and certificate programs offered and student program completions for fiscal year 2008-09 in North Dakota's public and private postsecondary educational institutions. Institutional programs are coded in accordance with the Classification of Instructional Programs (CIP Code) system provided by the National…

  3. Lapatinib inhibits CIP2A/PP2A/p-Akt signaling and induces apoptosis in triple negative breast cancer cells

    PubMed Central

    Liu, Chun-Yu; Hu, Ming-Hung; Hsu, Chia-Jung; Huang, Chun-Teng; Wang, Duen-Shian; Tsai, Wen-Chun; Chen, Yi-Ting; Lee, Chia-Han; Chu, Pei-Yi; Hsu, Chia-Chi; Chen, Ming-Huang; Shiau, Chung-Wai; Tseng, Ling-Ming; Chen, Kuen-Feng

    2016-01-01

    We tested the efficacy of lapatinib, a dual tyrosine kinase inhibitor which interrupts the HER2 and epidermal growth factor receptor (EGFR) pathways, in a panel of triple-negative breast cancer (TNBC) cells, and examined the drug mechanism. Lapatinib showed an anti-proliferative effect in HCC 1937, MDA-MB-468, and MDA-MB-231 cell lines. Lapatinib induced significant apoptosis and inhibited CIP2A and p-Akt in a dose and time-dependent manner in the three TNBC cell lines. Overexpression of CIP2A reduced lapatinib-induced apoptosis in MDA-MB-468 cells. In addition, lapatinib increased PP2A activity (in relation to CIP2A inhibition). Moreover, lapatinib-induced apoptosis and p-Akt downregulation was attenuated by PP2A antagonist okadaic acid. Furthermore, lapatinib indirectly decreased CIP2A transcription by disturbing the binding of Elk1 to the CIP2A promoter. Importantly, lapatinib showed anti-tumor activity in mice bearing MDA-MB-468 xenograft tumors, and suppressed CIP2A as well as p-Akt in these xenografted tumors. In summary, inhibition of CIP2A determines the effects of lapatinib-induced apoptosis in TNBC cells. In addition to being a dual tyrosine kinase inhibitor of HER2 and EGFR, lapatinib also inhibits CIP2A/PP2A/p-Akt signaling in TNBC cells. PMID:26824320

  4. Loss of Notch1-dependent p21Waf1/Cip1 expression influences the Notch1 outcome in tumorigenesis

    PubMed Central

    Cialfi, Samantha; Palermo, Rocco; Manca, Sonia; De Blasio, Carlo; Vargas Romero, Paula; Checquolo, Saula; Bellavia, Diana; Uccelletti, Daniela; Saliola, Michele; D'Alessandro, Angelo; Zolla, Lello; Gulino, Alberto; Screpanti, Isabella; Talora, Claudio

    2014-01-01

    Notch signaling plays a complex role in carcinogenesis, and its signaling pathway has both tumor-suppressor and oncogenic components. In this study we investigated the effects of reactive oxygen species (ROS) on Notch1 signaling outcome in keratinocyte biology. We demonstrate that Notch1 function contributes to the arsenic-induced keratinocyte transformation. We found that acute exposure to arsenite increases oxidative stress and inhibits proliferation of keratinocyte cells by upregulation of p21waf1/Cip1. The necessity of p21waf1/Cip1 for arsenite-induced cell death was demonstrated by targeted downregulation of p21waf1/Cip1 by using RNA interference. We further demonstrated that on acute exposure to arsenite, p21waf1/Cip1 is upregulated and Notch1 downmodulated, whereas on chronic exposure to arsenite, malignant progression of arsenite-treated keratinocytes cells was accompanied by regained expression and activity of Notch1. Notch1 activity in arsenite-transformed keratinocytes inhibits arsenite-induced upregulation of p21waf1/Cip1 by sustaining c-myc expression. We further demonstrated that c-myc collaborates with Nrf2, a key regulator for the maintenance of redox homeostasis, to promote metabolic activities that support cell proliferation and cytoprotection. Therefore, Notch1-mediated repression of p21waf1/Cip1 expression results in the inhibition of cell death and keratinocytes transformation. Our results not only demonstrate that sustained Notch1 expression is at least one key event implicated in the arsenite human skin carcinogenic effect, but also may provide mechanistic insights into the molecular aspects that determine whether Notch signaling will be either oncogenic or tumor suppressive. PMID:24801890

  5. A new fast accurate nonlinear medical image registration program including surface preserving regularization.

    PubMed

    Gruslys, Audrunas; Acosta-Cabronero, Julio; Nestor, Peter J; Williams, Guy B; Ansorge, Richard E

    2014-11-01

    Recently inexpensive graphical processing units (GPUs) have become established as a viable alternative to traditional CPUs for many medical image processing applications. GPUs offer the potential of very significant improvements in performance at low cost and with low power consumption. One way in which GPU programs differ from traditional CPU programs is that increasingly elaborate calculations per voxel may not impact of the overall processing time because memory accesses can dominate execution time. This paper presents a new GPU based elastic image registration program named Ezys. The Ezys image registration algorithm belongs to the wide class of diffeomorphic demons but uses surface preserving image smoothing and regularization filters designed for a GPU that would be computationally expensive on a CPU. We describe the methods used in Ezys and present results from two important neuroscience applications. Firstly inter-subject registration for transfer of anatomical labels and secondly longitudinal intra-subject registration to quantify atrophy in individual subjects. Both experiments showed that Ezys registration compares favorably with other popular elastic image registration programs. We believe Ezys is a useful tool for neuroscience and other applications, and also demonstrates the value of developing of novel image processing filters specifically designed for GPUs. PMID:24968094

  6. Preparation of methoxyl poly(ethylene glycol) (MPEG)-coated carbonyl iron particles (CIPs) and their application in potassium dihydrogen phosphate (KDP) magnetorheological finishing (MRF)

    NASA Astrophysics Data System (ADS)

    Ji, Fang; Xu, Min; Wang, Baorui; Wang, Chao; Li, Xiaoyuan; Zhang, Yunfei; Zhou, Ming; Huang, Wen; Wei, Qilong; Tang, Guangping; He, Jianguo

    2015-10-01

    KDP is a common type of optics that is extremely difficult to polish by the conventional route. MRF is a local polishing technology based on material removal via shearing with minimal normal load and sub-surface damage. In contrast to traditional emendation on an abrasive, the MPEG soft coating is designed and prepared to modify the CIP surface to achieve a hardness matched with that of KDP because CIP inevitably takes part in the material removal during finishing. Morphology and infrared spectra are explored to prove the existence of homogeneous coating, and the improvement of MPEG for the polishing quality is validated by the analysis of roughness, turning grooves, and stress. The synthesized MPEG-coated CIP (MPEG-CIP) is chemically and physically compatible with KDP, which can be removed after cleaning. Our research exhibits the promising prospects of MPEG-CIP in KDP MRF.

  7. Bioaerosol sampling by a personal rotating cup sampler CIP 10-M.

    PubMed

    Görner, Peter; Fabriès, Jean-François; Duquenne, Philippe; Witschger, Olivier; Wrobel, Richard

    2006-01-01

    High concentrations of bioaerosols containing bacterial, fungal and biotoxinic matter are encountered in many workplaces, e.g. solid waste treatment plants, waste water treatment plants and sewage networks. A personal bioaerosol sampler, the CIP 10-M (M-microbiologic), has been developed to measure worker exposure to airborne biological agents. This sampler is battery operated; it is light and easy to wear and offers full work shift autonomy. It can sample much higher concentrations than biological impactors and limits the mechanical stress on the microorganisms. Biological particles are collected in 2 ml of liquid medium inside a rotating cup fitted with radial vanes to maintain an air flow rate of 10 l min(-1) at a rotational speed of approximately 7,000 rpm. The rotating cup is made of sterilisable material. The sampled particles follow a helicoidal trajectory as they are pushed to the surface of the liquid by centrifugal force, which creates a thin vertical liquid layer. Sterile water or another collecting liquid can be used. Three particle size selectors allow health-related aerosol fractions to be sampled according to international conventions. The sampled microbiological particles can be easily recovered for counting, incubation or further biochemical analysis, e.g., for airborne endotoxins. Its physical sampling efficiency was laboratory tested and field trials were carried out in industrial waste management conditions. The results indicate satisfactory collection efficiency, whilst experimental application has demonstrated the usefulness of the CIP 10-M personal sampler for individual bioaerosol exposure monitoring. PMID:16395458

  8. Scientific Programs and Funding Opportunities at the National Institute of Biomedical Imaging and Bioengineering

    NASA Astrophysics Data System (ADS)

    Baird, Richard

    2006-03-01

    The mission of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) is to improve human health by promoting the development and translation of emerging technologies in biomedical imaging and bioengineering. To this end, NIBIB supports a coordinated agenda of research programs in advanced imaging technologies and engineering methods that enable fundamental biomedical discoveries across a broad spectrum of biological processes, disorders, and diseases and have significant potential for direct medical application. These research programs dramatically advance the Nation's healthcare by improving the detection, management and, ultimately, the prevention of disease. The research promoted and supported by NIBIB also is strongly synergistic with other NIH Institutes and Centers as well as across government agencies. This presentation will provide an overview of the scientific programs and funding opportunities supported by NIBIB, highlighting those that are of particular important to the field of medical physics.

  9. The National Cancer Informatics Program (NCIP) Annotation and Image Markup (AIM) Foundation model.

    PubMed

    Mongkolwat, Pattanasak; Kleper, Vladimir; Talbot, Skip; Rubin, Daniel

    2014-12-01

    Knowledge contained within in vivo imaging annotated by human experts or computer programs is typically stored as unstructured text and separated from other associated information. The National Cancer Informatics Program (NCIP) Annotation and Image Markup (AIM) Foundation information model is an evolution of the National Institute of Health's (NIH) National Cancer Institute's (NCI) Cancer Bioinformatics Grid (caBIG®) AIM model. The model applies to various image types created by various techniques and disciplines. It has evolved in response to the feedback and changing demands from the imaging community at NCI. The foundation model serves as a base for other imaging disciplines that want to extend the type of information the model collects. The model captures physical entities and their characteristics, imaging observation entities and their characteristics, markups (two- and three-dimensional), AIM statements, calculations, image source, inferences, annotation role, task context or workflow, audit trail, AIM creator details, equipment used to create AIM instances, subject demographics, and adjudication observations. An AIM instance can be stored as a Digital Imaging and Communications in Medicine (DICOM) structured reporting (SR) object or Extensible Markup Language (XML) document for further processing and analysis. An AIM instance consists of one or more annotations and associated markups of a single finding along with other ancillary information in the AIM model. An annotation describes information about the meaning of pixel data in an image. A markup is a graphical drawing placed on the image that depicts a region of interest. This paper describes fundamental AIM concepts and how to use and extend AIM for various imaging disciplines. PMID:24934452

  10. 12 CFR 1292.5 - Community Investment Cash Advance Programs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Community Investment Cash Advance Programs... COMMUNITY INVESTMENT CASH ADVANCE PROGRAMS § 1292.5 Community Investment Cash Advance Programs. (a) In... shall offer a CIP to provide financing for housing projects and for eligible targeted community...