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Sample records for including resistive mhd

  1. Problems in nonlinear resistive MHD

    SciTech Connect

    Turnbull, A.D.; Strait, E.J.; La Haye, R.J.; Chu, M.S.; Miller, R.L.

    1998-12-31

    Two experimentally relevant problems can relatively easily be tackled by nonlinear MHD codes. Both problems require plasma rotation in addition to the nonlinear mode coupling and full geometry already incorporated into the codes, but no additional physics seems to be crucial. These problems discussed here are: (1) nonlinear coupling and interaction of multiple MHD modes near the B limit and (2) nonlinear coupling of the m/n = 1/1 sawtooth mode with higher n gongs and development of seed islands outside q = 1.

  2. OpenMHD: Godunov-type code for ideal/resistive magnetohydrodynamics (MHD)

    NASA Astrophysics Data System (ADS)

    Zenitani, Seiji

    2016-04-01

    OpenMHD is a Godunov-type finite-volume code for ideal/resistive magnetohydrodynamics (MHD). It is written in Fortran 90 and is parallelized by using MPI-2 and OpenMP. The code was originally developed for studying magnetic reconnection problems and has been made publicly available in the hope that others may find it useful.

  3. Spectrum of resistive MHD modes in cylindrical plasmas

    SciTech Connect

    Ryu, C.M.; Grimm, R.C.

    1983-07-01

    A numerical study of the normal modes of a compressible resistive MHD fluid in cylindrical geometry is presented. Resistivity resolves the shear Alfven and slow magnetosonic continua of ideal MHD into discrete spectra and gives rise to heavily damped modes whose frequencies lie on specific lines in the complex plane. Fast magnetosonic waves are less affected but are also damped. Overstable modes arise from the shear Alfven spectrum. The stabilizing effect of favorable average curvature is shown. Eigenfunctions illustrating the nature of typical normal modes are displayed.

  4. Kinetic Effects of Energetic Particles on Resistive MHD Stability

    SciTech Connect

    Takahashi, R.; Brennan, D. P.; Kim, C. C.

    2009-04-03

    We show that the kinetic effects of energetic particles can play a crucial role in the stability of the m/n=2/1 tearing mode in tokamaks (e.g., JET, JT-60U, and DIII-D), where the fraction of energetic particle {beta}{sub frac} is high. Using model equilibria based on DIII-D experimental reconstructions, the nonideal MHD linear stability of cases unstable to the 2/1 mode is investigated including a {delta}f particle-in-cell model for the energetic particles coupled to the nonlinear 3D resistive MHD code NIMROD[C. C. Kim et al., Phys. Plasmas 15, 072507 (2008)]. It is observed that energetic particles have significant damping and stabilizing effects at experimentally relevant {beta}, {beta}{sub frac}, and S, and excite a real frequency of the 2/1 mode. Extrapolation of the results is discussed for implications to JET and ITER, where the effects are projected to be significant.

  5. Energy structure of MHD flow coupling with outer resistance circuit

    NASA Astrophysics Data System (ADS)

    Huang, Z. Y.; Liu, Y. J.; Chen, Y. Q.; Peng, Z. L.

    2015-08-01

    Energy structure of MHD flow coupling with outer resistance circuit is studied to illuminate qualitatively and quantitatively the energy relation of this basic MHD flow system with energy input and output. Energy structure are analytically derived based on the Navier-Stocks equations for two-dimensional fully-developed flow and generalized Ohm's Law. The influences of applied magnetic field, Hall parameter and conductivity on energy structure are discussed based on the analytical results. Associated energies in MHD flow are deduced and validated by energy conservation. These results reveal that energy structure consists of two sub structures: electrical energy structure and internal energy structure. Energy structure and its sub structures provide an integrated theoretical energy path of the MHD system. Applied magnetic field and conductivity decrease the input energy, dissipation by fluid viscosity and internal energy but increase the ratio of electrical energy to input energy, while Hall parameter has the opposite effects. These are caused by their different effects on Bulk velocity, velocity profiles, voltage and current in outer circuit. Understanding energy structure helps MHD application designers to actively adjust the allocation of different parts of energy so that it is more reasonable and desirable.

  6. MHD modeling of magnetotail instability for localized resistivity

    NASA Technical Reports Server (NTRS)

    Hesse, Michael; Birn, Joachim

    1994-01-01

    We present results of a three-dimensional magnetohydrodynamic (MHD) simulation of magnetotail evolution initiated by a sudden occurrence or increase of spatially localized resistivity as the major expected concequence of some localized microinstability. Because of the absence of a quantitative model, possible variations of resistivity levels with current density, or the reduction thereof, are not incorporated in the present investigation. The emphasis of the study is on an investigation of the changes to the overall evolution brought about by this localization, in particular, on the disruption and diversion of the cross-tail current and the nonlinear evolution of the magnetotail instability. The immediate consequences of the occurrence of the localized resistance and the resulting electric field are a reduction and diversion of the electric current around the region of high resistivity, associated with an increase of B(sub z) ('dipolarization') at the earthward edge and a decrease of B(sub z) at the tailward edge of this region. These effects, however, are localized and do not involve a reduction of the total cross-tail current and hence do not lead to the global development of a 'substorm current wedge,' which includes not only the reduction of the cross-tail current but also the buildup of a global field-aligned current system of 'regional 1' type (toward the Earth on the dawnside and away on the duskside of the tail). Such signatures develop at a later time, as consequences of a three-dimensional tearing instability, which is triggered by the occurrence of the resistivity. These features are found in combination with plasmoid formation and ejection, quite similar to results of earlier simulations with uniform resistivity. Differences are found in the timescale of the evolution, which tends to be shorter for localized resistivity, and in the propagation of the dipolarization effects in the equatorial plane. Whereas for uniform resistivity the temporal increase in

  7. Towards a Scalable Fully-Implicit Fully-coupled Resistive MHD Formulation with Stabilized FE Methods

    SciTech Connect

    Shadid, J N; Pawlowski, R P; Banks, J W; Chacon, L; Lin, P T; Tuminaro, R S

    2009-06-03

    This paper presents an initial study that is intended to explore the development of a scalable fully-implicit stabilized unstructured finite element (FE) capability for low-Mach-number resistive MHD. The discussion considers the development of the stabilized FE formulation and the underlying fully-coupled preconditioned Newton-Krylov nonlinear iterative solver. To enable robust, scalable and efficient solution of the large-scale sparse linear systems generated by the Newton linearization, fully-coupled algebraic multilevel preconditioners are employed. Verification results demonstrate the expected order-of-acuracy for the stabilized FE discretization of a 2D vector potential form for the steady and transient solution of the resistive MHD system. In addition, this study puts forth a set of challenging prototype problems that include the solution of an MHD Faraday conduction pump, a hydromagnetic Rayleigh-Bernard linear stability calculation, and a magnetic island coalescence problem. Initial results that explore the scaling of the solution methods are presented on up to 4096 processors for problems with up to 64M unknowns on a CrayXT3/4. Additionally, a large-scale proof-of-capability calculation for 1 billion unknowns for the MHD Faraday pump problem on 24,000 cores is presented.

  8. The ideal tearing mode: theory and resistive MHD simulations

    NASA Astrophysics Data System (ADS)

    Del Zanna, L.; Landi, S.; Papini, E.; Pucci, F.; Velli, M.

    2016-05-01

    Classical MHD reconnection theories, both the stationary Sweet-Parker model and the tearing instability, are known to provide rates which are too slow to explain the observations. However, a recent analysis has shown that there exists a critical threshold on current sheet's thickness, namely a/L ∼ S -1/3, beyond which the tearing modes evolve on fast macroscopic Alfvénic timescales, provided the Lunquist number S is high enough, as invariably found in solar and astrophysical plasmas. Therefore, the classical Sweet-Parker scenario, for which the diffusive region scales as a/L ∼ S -1/2 and thus can be up to ∼ 100 times thinner than the critical value, is likely to be never realized in nature, as the current sheet itself disrupts in the elongation process. We present here two-dimensional, compressible, resistive MHD simulations, with S ranging from 105 to 107, that fully confirm the linear analysis. Moreover, we show that a secondary plasmoid instability always occurs when the same critical scaling is reached on the local, smaller scale, leading to a cascading explosive process, reminiscent of the flaring activity.

  9. Resistive MHD studies of high-beta Tokamak plasmas

    NASA Astrophysics Data System (ADS)

    Lynch, V. E.; Hicks, H. R.; Holmes, J. A.; Carreras, B. A.; Garcia, L.

    1982-02-01

    The magnetohydrodynamic (MHD) activity in high beta Tokamaks such as ISX-B was calculated. These initial value calculations are built on earlier low beta techniques, but the beta effects create several new numerical issues. In addition to time stepping modules, the system of computer codes includes equilibrium solvers (used to provide an initial condition) and output modules, such as a magnetic field line follower and an X-ray diagnostic code. The transition from current driven modes a low beta to predominantly pressure driven modes at high beta is described. The nonlinear studies yield X-ray emissivity plots which are compared with experiment.

  10. A pressure-based high resolution numerical method for resistive MHD

    NASA Astrophysics Data System (ADS)

    Xisto, Carlos M.; Páscoa, José C.; Oliveira, Paulo J.

    2014-10-01

    In the paper we describe in detail a numerical method for the resistive magnetohydrodynamic (MHD) equations involving viscous flow and report the results of application to a number of typical MHD test cases. The method is of the finite volume type but mixes aspects of pressure-correction and density based solvers; the algorithm arrangement is patterned on the well-known PISO algorithm, which is a pressure method, while the flux computation makes use of the AUSM-MHD scheme, which originates from density based methods. Five groups of test cases are addressed to verify and validate the method. We start with two resistive MHD cases, namely the Shercliff and Hunt flow problems, which are intended to validate the method for low-speed resistive MHD flows. The remaining three test cases, namely the cloud-shock interaction, the MHD rotor and the MHD blast wave, are standard 2D ideal MHD problems that serve to validate the method under high-speed flow and complex interaction of MHD shocks. Finally, we demonstrate the method with a more complex application problem, and discuss results of simulation for a quasi-bi-dimensional self-field magnetoplasmadynamic (MPD) thruster, for which we study the effect of cathode length upon the electromagnetic nozzle performance.

  11. Resistive MHD studies of high-. beta. -tokamak plasmas

    SciTech Connect

    Lynch, V.E.; Carreras, B.A.; Hicks, H.R.; Holmes, J.A.; Garcia, L.

    1981-01-01

    Numerical calculations have been performed to study the MHD activity in high-..beta.. tokamaks such as ISX-B. These initial value calculations built on earlier low ..beta.. techniques, but the ..beta.. effects create several new numerical issues. These issues are discussed and resolved. In addition to time-stepping modules, our system of computer codes includes equilibrium solvers (used to provide an initial condition) and output modules, such as a magnetic field line follower and an X-ray diagnostic code. The transition from current driven modes at low ..beta.. to predominantly pressure driven modes at high ..beta.. is described. The nonlinear studies yield X-ray emissivity plots which are compared with experiment.

  12. A Numerical Study of Resistivity and Hall Effects for a Compressible MHD Model

    NASA Technical Reports Server (NTRS)

    Yee, H. C.; Sjogreen, B.

    2005-01-01

    The effect of resistive, Hall, and viscous terms on the flow structure compared with compressible ideal MHD is studied numerically for a one-fluid non-ideal MHD model. The goal of the present study is to shed some light on the emerging area of non-ideal MHD modeling and simulation. Numerical experiments are performed on a hypersonic blunt body flow with future application to plasma aerodynamics flow control in reentry vehicles. Numerical experiments are also performed on a magnetized time-developing mixing layer with possible application to magnetic/turbulence mixing.

  13. Scalable implicit incompressible resistive MHD with stabilized FE and fully-coupled Newton–Krylov-AMG

    DOE PAGESBeta

    Shadid, J. N.; Pawlowski, R. P.; Cyr, E. C.; Tuminaro, R. S.; Chacon, L.; Weber, P. D.

    2016-02-10

    Here, we discuss that the computational solution of the governing balance equations for mass, momentum, heat transfer and magnetic induction for resistive magnetohydrodynamics (MHD) systems can be extremely challenging. These difficulties arise from both the strong nonlinear, nonsymmetric coupling of fluid and electromagnetic phenomena, as well as the significant range of time- and length-scales that the interactions of these physical mechanisms produce. This paper explores the development of a scalable, fully-implicit stabilized unstructured finite element (FE) capability for 3D incompressible resistive MHD. The discussion considers the development of a stabilized FE formulation in context of the variational multiscale (VMS) method,more » and describes the scalable implicit time integration and direct-to-steady-state solution capability. The nonlinear solver strategy employs Newton–Krylov methods, which are preconditioned using fully-coupled algebraic multilevel preconditioners. These preconditioners are shown to enable a robust, scalable and efficient solution approach for the large-scale sparse linear systems generated by the Newton linearization. Verification results demonstrate the expected order-of-accuracy for the stabilized FE discretization. The approach is tested on a variety of prototype problems, that include MHD duct flows, an unstable hydromagnetic Kelvin–Helmholtz shear layer, and a 3D island coalescence problem used to model magnetic reconnection. Initial results that explore the scaling of the solution methods are also presented on up to 128K processors for problems with up to 1.8B unknowns on a CrayXK7.« less

  14. Free-Boundary 3D Equilibria and Resistive Wall Instabilities with Extended-MHD

    NASA Astrophysics Data System (ADS)

    Ferraro, N. M.

    2015-11-01

    The interaction of the plasma with external currents, either imposed or induced, is a critical element of a wide range of important tokamak phenomena, including resistive wall mode (RWM) stability and feedback control, island penetration and locking, and disruptions. A model of these currents may be included within the domain of extended-MHD codes in a way that preserves the self-consistency, scalability, and implicitness of their numerical methods. Such a model of the resistive wall and non-axisymmetric coils is demonstrated using the M3D-C1 code for a variety of applications, including RWMs, perturbed non-axisymmetric equilibria, and a vertical displacement event (VDE) disruption. The calculated free-boundary equilibria, which include Spitzer resistivity, rotation, and two-fluid effects, are compared to external magnetic and internal thermal measurements for several DIII-D discharges. In calculations of the perturbed equilibria in ELM suppressed discharges, the tearing response at the top of the pedestal is found to correlate with the onset of ELM suppression. Nonlinear VDE calculations, initialized using a vertically unstable DIII-D equilibrium, resolve in both space and time the currents induced in the wall and on the plasma surface, and also the currents flowing between the plasma and the wall. The relative magnitude of these contributions and the total impulse to the wall depend on the resistive wall time, although the maximum axisymmetric force on the wall over the course of the VDE is found to be essentially independent of the wall conductivity. This research was supported by US DOE contracts DE-FG02-95ER54309, DE-FC02-04ER54698 and DE-AC52-07NA27344.

  15. Proceedings of the workshop on nonlinear MHD and extended MHD

    SciTech Connect

    1998-12-01

    Nonlinear MHD simulations have proven their value in interpreting experimental results over the years. As magnetic fusion experiments reach higher performance regimes, more sophisticated experimental diagnostics coupled with ever expanding computer capabilities have increased both the need for and the feasibility of nonlinear global simulations using models more realistic than regular ideal and resistive MHD. Such extended-MHD nonlinear simulations have already begun to produce useful results. These studies are expected to lead to ever more comprehensive simulation models in the future and to play a vital role in fully understanding fusion plasmas. Topics include the following: (1) current state of nonlinear MHD and extended-MHD simulations; (2) comparisons to experimental data; (3) discussions between experimentalists and theorists; (4) /equations for extended-MHD models, kinetic-based closures; and (5) paths toward more comprehensive simulation models, etc. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.

  16. Computational modeling of neoclassical and resistive MHD tearing modes in tokamaks

    SciTech Connect

    Gianakon, T.A.

    1996-02-01

    Numerical studies of the linear and nonlinear evolution of magnetic tearing type modes in three-dimensional toroidal geometry are presented. In addition to traditional resistive MHD effects, where the parameter {Delta}{prime} determines the stability properties, neoclassical effects have been included for the first time in such models. The inclusion of neoclassical physics introduces and additional free-energy source for the nonlinear formation of magnetic islands through the effects of a bootstrap current in Ohm`s law. The neoclassical tearing mode is demonstrated to be destabilized in plasmas which are otherwise {Delta}{prime} stable, albeit once an island width threshold is exceeded. The simulations are based on a set of neoclassical reduced magnetohydrodynamic (MHD) equations in three-dimensional toroidal geometry derived from the two-fluid equations in the limit of small inverse aspect ratio {epsilon} and low plasma pressure {beta} with neoclassical closures for the viscous force {del} {center_dot} {leftrightarrow}{pi}. The poloidal magnetic flux {psi}, the toroidal vorticity {omega}{sup {zeta}}, and the plasma pressure p are time advanced using the parallel projection of Ohm`s law, the toroidal projection of the curl of the momentum equation, and a pressure evolution equation with anisotropic pressure transport parallel to and across magnetic field lines. The equations are implemented in an initial value code which Fourier decomposes equilibrium and perturbation quantities in the poloidal and toroidal directions, and finite differences them radially based on a equilibrium straight magnetic field line representation. An implicit algorithm is used to advance the linear terms; the nonlinear terms are advanced explicitly. The simulations are benchmarked linearly and nonlinearly against single and multiple helicity {Delta}{prime} tearing modes in toroidal geometry in the absence of neo-classical effects.

  17. Impact of resistive MHD plasma response on perturbation field sidebands

    NASA Astrophysics Data System (ADS)

    Orlov, D. M.; Evans, T. E.; Moyer, R. A.; Lyons, B. C.; Ferraro, N. M.; Park, G.-Y.

    2016-07-01

    Single fluid linear simulations of a KSTAR RMP ELM suppressed discharge with the M3D-C1 resistive magnetohydrodynamic code have been performed for the first time. The simulations show that the application of the n  =  1 perturbation using the KSTAR in-vessel control coils (IVCC), which apply modest levels of n  =  3 sidebands (~20% of the n  =  1), leads to levels of n  =  3 sideband that are comparable to the n  =  1 when plasma response is included. This is due to the reduced level of screening of the rational-surface-resonant n  =  3 component relative to the rational-surface-resonant n  =  1 component. The n  =  3 sidebands could play a similar role in ELM suppression on KSTAR as the toroidal sidebands (n  =  1, 2, 4) in DIII-D n  =  3 ELM suppression with missing I-coil segments (Paz Soldan et al 2014 Nucl. Fusion 54 073013). This result may help to explain the uniqueness of ELM suppression with n  =  1 perturbations in KSTAR since the effective perturbation is a mixed n  =  1/n  =  3 perturbation similar to n  =  3 ELM suppression in DIII-D.

  18. Linear Analysis of the m=0 Instability for a Visco-resistive Hall MHD Plasma

    SciTech Connect

    Oliver, B.V.; Genoni, T.C.; Mehlhorn, T.A.

    2006-01-05

    We present a comprehensive analysis of the linear dispersion relation for the axisymmetric (m=0) compressible interchange instability of Bennett equilibria in a visco-resistive, Hall MHD plasma. The full anisotropic stress tensor with Braginskii viscous coefficients is considered. The eigenvalues are obtained numerically. For small axial mode number, Hall currents enhance the growth rates, whereas in the limit of high mode number the growth rates are suppressed, eventually resulting in wave cutoff, even in the ideal limit. For the visco-resistive plasma the unstable spectra are weakly dependent on the off-diagonal elements of the stress tensor.

  19. Interelectrode resistance and performance of small and large scale MHD generators

    SciTech Connect

    Doss, E.D.; Picologlou, B.F.

    1983-09-01

    The effect of reduced interelectrode resistance in MHD generators on the generator power output is investigated. The analytical model used in the investigation allows for the solution for the electric field and current density distributions in the cross plane of the generator. The power output, expressed as a fraction of the power output of a perfectly insulated generator, is found to be a function of the wall temperature, the ratio of boundary layer thickness to channel transverse dimension, and the product of interelectrode resistance and channel cross-sectional area. The interelectrode resistance is assumed to be inversely proportional to the channel transverse dimension and the variation of power output ratio with channel size is calculated. It is found that deterioration of performance of NHD generators, resulting from reduced interelectrode resistance, diminishes with generator size and is negligible for large-scale generators, provided that the interelectrode resistance remains larger than an order of one-tenth ohm.

  20. Modeling of magnetic reconnection in the magnetotail using global MHD simulation with an effective resistivity model

    NASA Astrophysics Data System (ADS)

    Den, M.; Horiuchi, R.; Fujita, S.; Tanaka, T.

    2011-12-01

    Magnetic reconnection is considered to play an important role in space phenomena such as substorm in the Earth's magnetosphere. Tanaka and Fujita reproduced substorm evolution process by numerical simulation with the global MHD code [1]. In the MHD framework, the dissipation model is introduced for modeling of the kinetic effects. They found that the normalized reconnection viscosity, one of the dissipation model employed there, gave a large effect for the dipolarization, central phenomenon in the substorm development process, though that viscosity was assumed to be a constant parameter. It is well known that magnetic reconnection is controlled by microscopic kinetic mechanism. Frozen-in condition is broken due to particle kinetic effects and collisionless reconnection is triggered when current sheet is compressed as thin as ion kinetic scales under the influence of external driving flow [2, 3]. Horiuchi and his collaborators showed that reconnection electric field generated by microscopic physics evolves inside ion meandering scale so as to balance the flux inflow rate at the inflow boundary, which is controlled by macroscopic physics [2]. That is, effective resistivity generated through this process can be expressed by balance equation between micro and macro physics. In this paper, we perform substorm simulation by using the global MHD code developed by Tanaka [3] with this effective resistivity instead of the empirical resistivity model. We obtain the AE indices from simulation data, in which substorm onset can be seen clearly, and investigate the relationship between the substorm development and the effective resistivity model. [1] T. Tanaka, A, Nakamizo, A. Yoshikawa, S. Fujita, H. Shinagawa, H. Shimazu, T. Kikuchi, and K. K. Hashimoto, J. Geophys. Res. 115 (2010) A05220,doi:10.1029/2009JA014676. [2] W. Pei, R. Horiuchi, and T. Sato, Physics of Plasmas,Vol. 8 (2001), pp. 3251-3257. [3] A. Ishizawa, and R. Horiuchi, Phys. Rev. Lett., Vol. 95, 045003 (2005). [4

  1. Minimally implicit Runge-Kutta methods for Resistive Relativistic MHD

    NASA Astrophysics Data System (ADS)

    Aloy, Miguel-Á.; Cordero-Carrión, Isabel

    2016-05-01

    The Relativistic Resistive Magnetohydrodynamic (RRMHD) equations are a hyperbolic system of partial differential equations used to describe the dynamics of relativistic magnetized fluids with a finite conductivity. Close to the ideal magnetohydrodynamic regime, the source term proportional to the conductivity becomes potentially stiff and cannot be handled with standard explicit time integration methods. We propose a new class of methods to deal with the stiffness fo the system, which we name Minimally Implicit Runge-Kutta methods. These methods avoid the development of numerical instabilities without increasing the computational costs in comparison with explicit methods, need no iterative extra loop in order to recover the primitive (physical) variables, the analytical inversion of the implicit operator is trivial and the several stages can actually be viewed as stages of explicit Runge-Kutta methods with an effective time-step. We test these methods with two different one-dimensional test beds in varied conductivity regimes, and show that our second-order schemes satisfy the theoretical expectations.

  2. Evolution of generalized two-dimensional magnetotail equilibria in ideal and resistive MHD

    NASA Astrophysics Data System (ADS)

    Merkin, V. G.; Sitnov, M. I.; Lyon, J. G.

    2015-03-01

    We present results of two-dimensional (2-D) magnetohydrodynamic (MHD) simulations of the terrestrial magnetotail. A regional adaptation of the Lyon-Fedder-Mobarry global MHD model is used. As initial conditions, we employ a class of asymptotic magnetotail equilibria with and without an accumulation of magnetic flux at the tailward end (a Bz hump). The former have been recently shown by full particle simulations to be unstable to a kinetic mode with formal properties of ion tearing. Thus, our goal here is to investigate the evolution of the same equilibria in the MHD approximation and assist in the physical interpretation of the kinetic simulations. This is additionally motivated by the energy principle considerations which suggest that if the system is unstable kinetically, it may also be unstable ideally. To seek dynamical MHD regimes similar to those observed in kinetic simulations, we implement two sets of boundary conditions (velocity balanced, VB, and momentum balanced, MB), one allowing plasma flows through the boundaries and the other inhibiting such flows. The use of more reflecting MB boundary conditions results in suppression of any significant dynamics, and we see no substantial changes beyond initial equilibrium relaxation. On the other hand, VB boundary conditions allow a more efficient relaxation of initial equilibrium and absorb subsequently generated plasma flows. With these boundary conditions we find the equilibrium without a flux accumulation (i.e., with constant magnetic field component normal to the current sheet) to develop an apparently resistive mode accompanied by tailward plasma flows. At the same time, the equilibria with a Bz hump of sufficiently large amplitude develop a different, ideal, mode characterized by spontaneous generation of earthward plasma flows and an exponential growth of the corresponding electric field. This growth is qualitatively similar to the corresponding fully kinetic simulations although no explosive growth of

  3. Heat transfer including radiation and slag particles evolution in MHD channel-I

    SciTech Connect

    Im, K.H.; Ahluwalia, R.K.

    1980-01-01

    Accurate estimates of convective and radiative heat transfer in the magnetohydrodynamic channel are provided. Calculations performed for a base load-size channel indicate that heat transfer by gas radiation almost equals that by convection for smooth walls, and amounts to 70% as much as the convective heat transfer for rough walls. Carbon dioxide, water vapor, and potassium atoms are the principal participating gases. The evolution of slag particles by homogeneous nucleation and condensation is also investigated. The particle-size spectrum so computed is later utilized to analyze the radiation enhancement by slag particles in the MHD diffuser. The impact of the slag particle spectrum on the selection of a workable and design of an efficient seed collection system is discussed.

  4. MHD computation of feedback of resistive-shell instabilities in the reversed field pinch

    SciTech Connect

    Zita, E.J.; Prager, S.C. . Plasma Physics Research); Ho, Y.L.; Schnack, D.D )

    1992-05-01

    MHD computation demonstrates that feedback can sustain reversal and reduce loop voltage in resistive-shell reversed field pinch (RFP) plasmas. Edge feedback on {approximately}2R/a tearing modes resonant near axis is found to restore plasma parameters to nearly their levels with a close-fitting conducting shell. When original dynamo modes are stabilized, neighboring tearing modes grow to maintain the RFP dynamo more efficiently. This suggests that experimentally observed limits on RFP pulselengths to the order of the shell time can be overcome by applying feedback to a few helical modes.

  5. MHD Instabilities Occurring Near/AT the Transport Barrier, Including Loss of Confinement in H-Modes

    SciTech Connect

    L. L. Lao

    1999-09-01

    In configurations with transport barriers the improved edge and core confinement leads to large pressure gradient and large edge bootstrap current density which often drive magnetohydrodynamic (MHD) instabilities terminating the discharge or reducing the discharge performance. The edge and the core transport barriers deteriorate or are completely lost. In this presentation, recent experimental and theoretical developments concerning MHD instabilities occurring near/at the edge and the core transport barriers are summarized emphasizing the dominant instabilities and the comparison with theory.

  6. Including Religion in American History: Some Notes on Student Resistance.

    ERIC Educational Resources Information Center

    Talbert, Kevin M.; Romanowski, Michael H.

    2002-01-01

    Focuses on the importance of teaching religion in U.S. history courses. Discusses problems that teachers encounter when teaching religion, addresses the issue of students resisting learning about religion in the history classroom, and explores how teachers can reduce this resistance. Includes references. (CMK)

  7. Global existence and uniqueness theorem to 2-D incompressible non-resistive MHD system with non-equilibrium background magnetic field

    NASA Astrophysics Data System (ADS)

    Zhai, Cuili; Zhang, Ting

    2016-09-01

    In this article, we consider the global existence and uniqueness of the solution to the 2D incompressible non-resistive MHD system with non-equilibrium background magnetic field. Our result implies that a strong enough non-equilibrium background magnetic field will guarantee the stability of the nonlinear MHD system. Beside the classical energy method, the interpolation inequalities and the algebraic structure of the equations coming from the incompressibility of the fluid are crucial in our arguments.

  8. Magnetic turbulence and resistive MHD instabilities in a 0. 6 < q < 3 poloidal divertor tokamak

    SciTech Connect

    Agim, Y.Z.; Callen, J.D.; Chang, Z.; Dexter, R.N.; Goetz, J.A.; Graessle, D.E.; Haines, E.; Kortbawi, D.; LaPointe, M.A.; Moyer, R.A.

    1988-09-01

    Detailed statistical properties of internal magnetic turbulence, and internal disruptions in magnetically- and materially-limited discharges, are studied in the Tokapole II poloidal divertor tokamak over the safety factor range 0.6 < q{sub a} < 3. A nonlinear MHD code treats tearing modes in the divertor geometry. 9 refs., 2 figs.

  9. Computational modeling of neoclassical and resistive MHD tearing modes in tokamaks

    SciTech Connect

    Gianakon, T.A.; Hegna, C.C.; Callen, J.D.

    1996-06-24

    Numerical studies of the nonlinear evolution of MHD-type tearing modes in three-dimensional toroidal geometry with neoclassical effects are presented. The inclusion of neoclassical physics introduces an additional free-energy source for the nonlinear formation of magnetic islands through the effects of a bootstrap current in Ohm`s law. The neoclassical tearing mode is demonstrated to be destabilized in plasmas which are otherwise {Delta}` stable, albeit once an island width threshold is exceeded. The plasma pressure dynamics and neoclassical tearing growth is shown to be sensitive to the choice of the ratio of the parallel to perpendicular diffusivity ({Chi}{parallel}/{Chi}{perpendicular}). The study is completed with a demonstration and theoretical comparison of the threshold for single helicity neoclassical MHD tearing modes, which is described based on parameter scans of the local pressure gradient, the ratio of perpendicular to parallel pressure diffusivities {Chi}{perpendicular}/{Chi}{parallel}, and the magnitude of an initial seed magnetic perturbation.

  10. Sugarcane Aphid (Hemiptera: Aphididae): Host Range and Sorghum Resistance Including Cross-Resistance From Greenbug Sources.

    PubMed

    Armstrong, J Scott; Rooney, William L; Peterson, Gary C; Villenueva, Raul T; Brewer, Michael J; Sekula-Ortiz, Danielle

    2015-04-01

    The graminous host range and sources of sorghum [Sorghum bicolor (L.) Moench.] plant resistance, including cross-resistance from greenbug, Schizaphis graminum (Rondani), were studied for the newly emerging sugarcane aphid, Melanaphis sacchari (Zehntner), in greenhouse no-choice experiments and field evaluations. The sugarcane aphid could not survive on field corn, Zea mays (L.), Teff grass, Eragrostis tef (Zucc.), proso millet, Panicum miliaceum L., barley, Hordeum vulgare L., and rye, Secale cereale L. Only sorghum genotypes served as hosts including Johnsongrass, Sorghum halepense (L.), a highly suitable noncrop host that generates high numbers of sugarcane aphid and maintains moderate phenotypic injury. The greenbug-resistant parental line RTx2783 that is resistant to greenbug biotypes C and E was resistant to sugarcane aphid in both greenhouse and field tests, while PI 55607 greenbug resistant to biotypes B, C, and E was highly susceptible. PI 55610 that is greenbug resistant to biotypes B, C, and E maintained moderate resistance to the sugarcane aphid, while greenbug-resistant PI 264453 was highly susceptible to sugarcane aphid. Two lines and two hybrids from the Texas A&M breeding program B11070, B11070, AB11055-WF1-CS1/RTx436, and AB11055-WF1-CS1/RTx437 were highly resistant to sugarcane aphid, as were parental types SC110, SC170, and South African lines Ent62/SADC, (Macia/TAM428)-LL9, (SV1*Sima/IS23250)-LG15. Tam428, a parental line that previously showed moderate resistance in South Africa and India, also showed moderate resistance in these evaluations. Overall, 9 of 20 parental sorghum entries tested for phenotypic damage in the field resulted in good resistance to the sugarcane aphid and should be utilized in breeding programs that develop agronomically acceptable sorghums for the southern regions of the United States. PMID:26470168

  11. Plasmoid dynamics in 3D resistive MHD simulations of magnetic reconnection

    NASA Astrophysics Data System (ADS)

    Samtaney, R.; Loureiro, N. F.; Uzdensky, D. A.; Schekochihin, A. A.

    2012-04-01

    Magnetic reconnection is a well known plasma process believed to lie at the heart of a variety of phenomena such as sub-storms in the Earth's magnetosphere, solar/stellar and accretion-disk flares, sawteeth activity in fusion devices, etc. During reconnection, the global magnetic field topology changes rapidly, leading to the violent release of magnetic energy. Over the past few years, the basic understanding of this fundamental process has undergone profound changes. The validity of the most basic, and widely accepted, reconnection paradigm - the famous Sweet-Parker (SP) model, which predicts that, in MHD, reconnection is extremely slow, its rate scaling as S-1/2, where S is the Lundquist number of the system - has been called into question as it was analytically demonstrated that, for S ≫ 1, SP-like current sheets are violently unstable to the formation of a large number of secondary islands, or plasmoids. Subsequent numerical simulations in 2D have confirmed the validity of the linear theory, and shown that plasmoids quickly grow to become wider than the thickness of the original SP current sheet, thus effectively changing the underlying reconnection geometry. Ensuing numerical work has revealed that the process of plasmoid formation, coalescence and ejection from the sheet drastically modifies the steady state picture assumed by Sweet and Parker, and leads to the unexpected result that MHD reconnection is independent of S. In this talk, we review these recent developments and present results from three-dimensional simulations of high-Lundquist number reconnection in the presence of a guide field. A parametric study varying the strength of the guide field is presented. Plasmoid flux and width distribution functions are quantified and compared with corresponding two dimensional simulations.

  12. Modeling of fast neutral-beam-generated ion effects on MHD-spectroscopic observations of resistive wall mode stability in DIII-D plasmas

    SciTech Connect

    Turco, F. Hanson, J. M.; Navratil, G. A.; Turnbull, A. D.

    2015-02-15

    Experiments conducted at DIII-D investigate the role of drift kinetic damping and fast neutral beam injection (NBI)-ions in the approach to the no-wall β{sub N} limit. Modelling results show that the drift kinetic effects are significant and necessary to reproduce the measured plasma response at the ideal no-wall limit. Fast neutral-beam ions and rotation play important roles and are crucial to quantitatively match the experiment. In this paper, we report on the model validation of a series of plasmas with increasing β{sub N}, where the plasma stability is probed by active magnetohydrodynamic (MHD) spectroscopy. The response of the plasma to an externally applied field is used to probe the stable side of the resistive wall mode and obtain an indication of the proximity of the equilibrium to an instability limit. We describe the comparison between the measured plasma response and that calculated by means of the drift kinetic MARS-K code [Liu et al., Phys. Plasmas 15, 112503 (2008)], which includes the toroidal rotation, the electron and ion drift-kinetic resonances, and the presence of fast particles for the modelled plasmas. The inclusion of kinetic effects allows the code to reproduce the experimental results within ∼13% for both the amplitude and phase of the plasma response, which is a significant improvement with respect to the undamped MHD-only model. The presence of fast NBI-generated ions is necessary to obtain the low response at the highest β{sub N} levels (∼90% of the ideal no-wall limit). The toroidal rotation has an impact on the results, and a sensitivity study shows that a large variation in the predicted response is caused by the details of the rotation profiles at high β{sub N}.

  13. Extended-MHD modeling of diamagnetic-drift tearing instabilities

    NASA Astrophysics Data System (ADS)

    King, Jacob; Kruger, Scott

    2012-03-01

    We use analytics and computations with the NIMROD code to examine tearing stability in large-guide-field slab cases with a nonzero equilibrium pressure gradient. A well known result from drift-reduced MHD is the diamagnetic drift associated with the pressure gradient has a stabilizing influence were the dispersion relation becomes (γ+iφ*e)^3γ(γ+iφ*i)=γrMHD^5 [1]. Here φ*i and φ*e are the ion- and electron-diamagnetic frequencies and γrMHD is the tearing growth rate with a resistive-MHD model. Preliminary computational results with an unreduced extended-MHD model do not produce the expected drift-reduced result. For moderate values of φ*i (φ*i<=3γrMHD), the computations follow the dispersion relation that would result if the ∇pe term were not included in the drift-reduced parallel Ohm's law: (γ+iφ*e)^4(γ+iφ*i)=γrMHD^5. Analytics, guided by computational diagnostics, are used to examine the significant terms in the flux evolution equation and investigate the discrepancy with the drift-reduced result.[4pt] [1] For example Coppi, PoF 7, 1501 (1964); Biskamp, NF 18, 1059 (1978).

  14. Ideal MHD

    NASA Astrophysics Data System (ADS)

    Freidberg, Jeffrey P.

    2014-06-01

    1. Introduction; 2. The ideal MHD model; 3. General properties of ideal MHD; 5. Equilibrium: one-dimensional configurations; 6. Equilibrium: two-dimensional configurations; 7. Equilibrium: three-dimensional configurations; 8. Stability: general considerations; 9. Alternate MHD models; 10. MHD stability comparison theorems; 11. Stability: one-dimensional configurations; 12. Stability: multi-dimensional configurations; Appendix A. Heuristic derivation of the kinetic equation; Appendix B. The Braginskii transport coefficients; Appendix C. Time derivatives in moving plasmas; Appendix D. The curvature vector; Appendix E. Overlap limit of the high b and Greene-Johnson stellarator models; Appendix F. General form for q(y); Appendix G. Natural boundary conditions; Appendix H. Upper and lower bounds on dQKIN.

  15. Plasma stability theory including the resistive wall effects

    NASA Astrophysics Data System (ADS)

    Pustovitov, V. D.

    2015-12-01

    > Plasma stabilization due to a nearby conducting wall can provide access to better performance in some scenarios in tokamaks. This was proved by experiments with an essential gain in and demonstrated as a long-lasting effect at sufficiently fast plasma rotation in the DIII-D tokamak (see, for example, Strait et al., Nucl. Fusion, vol. 43, 2003, pp. 430-440). The rotational stabilization is the central topic of this review, though eventually the mode rotation gains significance. The analysis is based on the first-principle equations describing the energy balance with dissipation in the resistive wall. The method emphasizes derivation of the dispersion relations for the modes which are faster than the conventional resistive wall modes, but slower than the ideal magnetohydrodynamics modes. Both the standard thin wall and ideal-wall approximations are not valid in this range. Here, these are replaced by an approach incorporating the skin effect in the wall. This new element in the stability theory makes the energy sink a nonlinear function of the complex growth rate. An important consequence is that a mode rotating above a critical level can provide a damping effect sufficient for instability suppression. Estimates are given and applications are discussed.

  16. Enhanced neo-classical resistivity due to the m/n = 1/1 MHD-mode deformation of the central core plasma column for the tokamak hybrid scenario

    NASA Astrophysics Data System (ADS)

    Takizuka, T.

    2014-09-01

    The tokamak hybrid scenario, a combination of the inductive current drive and the non-inductive current drive, aims at high neutron fluence and a long pulse length for the ITER engineering test towards DEMO. It has been reported experimentally that the concentration of current density, J, peculiar to inductive discharges, was much smaller than that of a simple estimation. We propose a new model to explain the above observations: the central core plasma column can be non-axisymmetric due to the m/n = 1/1 MHD-mode deformation (m and n are poloidal and toroidal mode numbers, respectively). The neo-classical resistivity is enhanced, and the diagnostics are affected. An internal kink mode is a candidate of this instability. Compared with the JT-60U experiment, the reconstructed J profile agrees well with the calculated J profile including the enhanced neo-classical resistivity.

  17. Generalized reduced MHD equations

    SciTech Connect

    Kruger, S.E.; Hegna, C.C.; Callen, J.D.

    1998-07-01

    A new derivation of reduced magnetohydrodynamic (MHD) equations is presented. A multiple-time-scale expansion is employed. It has the advantage of clearly separating the three time scales of the problem associated with (1) MHD equilibrium, (2) fluctuations whose wave vector is aligned perpendicular to the magnetic field, and (3) those aligned parallel to the magnetic field. The derivation is carried out without relying on a large aspect ratio assumption; therefore this model can be applied to any general toroidal configuration. By accounting for the MHD equilibrium and constraints to eliminate the fast perpendicular waves, equations are derived to evolve scalar potential quantities on a time scale associated with the parallel wave vector (shear-alfven wave time scale), which is the time scale of interest for MHD instability studies. Careful attention is given in the derivation to satisfy energy conservation and to have manifestly divergence-free magnetic fields to all orders in the expansion parameter. Additionally, neoclassical closures and equilibrium shear flow effects are easily accounted for in this model. Equations for the inner resistive layer are derived which reproduce the linear ideal and resistive stability criterion of Glasser, Greene, and Johnson.

  18. Nonlinear Resistive MHD Computations of PPCD and Cross Section Shaping in the RFP

    NASA Astrophysics Data System (ADS)

    Reynolds, J. M.; Sovinec, C. R.

    2002-11-01

    A study of plasma dynamics during Pulsed Poloidal Current Drive (PPCD) in the reversed field pinch is conducted with non-ideal magnetohydrodynamic simulations in cylindrical and toroidal geometry using the NIMROD code [http://nimrodteam.org]. Finite pressure simulations at a Lundquist number of S ˜2000 show a marked reduction in core-resonant dynamo activity and increases in instantaneous energy confinement time commensurate with applied poloidal electric field strength (up to 66% increase in the strongest electric field case). A mode-decomposition study with varied numbers of toroidal Fourier components and an analysis of the contributions to Ohm's law uncovers the dominant mechanisms governing the parallel current profile evolution. Computational studies at S-values greater than 2000, including a scaling study of the effects of Lundquist number on magnetic fluctuation reduction, is underway. We are also investigating how shaping the poloidal cross section affects nonlinear fluctuation amplitudes and coupling in the absence of PPCD.

  19. Investigation of island formation due to RMPs in DIII-D plasmas with the SIESTA resistive MHD equilibrium code

    NASA Astrophysics Data System (ADS)

    Hirshman, S. P.; Shafer, M. W.; Seal, S. K.; Canik, J. M.

    2016-04-01

    > The SIESTA magnetohydrodynamic (MHD) equilibrium code has been used to compute a sequence of ideally stable equilibria resulting from numerical variation of the helical resonant magnetic perturbation (RMP) applied to an axisymmetric DIII-D plasma equilibrium. Increasing the perturbation strength at the dominant , resonant surface leads to lower MHD energies and increases in the equilibrium island widths at the (and sidebands) surfaces, in agreement with theoretical expectations. Island overlap at large perturbation strengths leads to stochastic magnetic fields which correlate well with the experimentally inferred field structure. The magnitude and spatial phase (around the dominant rational surfaces) of the resonant (shielding) component of the parallel current are shown to change qualitatively with the magnetic island topology.

  20. Resistive reduced MHD modeling of multi-edge-localized-mode cycles in Tokamak X-point plasmas.

    PubMed

    Orain, F; Bécoulet, M; Huijsmans, G T A; Dif-Pradalier, G; Hoelzl, M; Morales, J; Garbet, X; Nardon, E; Pamela, S; Passeron, C; Latu, G; Fil, A; Cahyna, P

    2015-01-23

    The full dynamics of a multi-edge-localized-mode (ELM) cycle is modeled for the first time in realistic tokamak X-point geometry with the nonlinear reduced MHD code jorek. The diamagnetic rotation is found to be instrumental to stabilize the plasma after an ELM crash and to model the cyclic reconstruction and collapse of the plasma pressure profile. ELM relaxations are cyclically initiated each time the pedestal gradient crosses a triggering threshold. Diamagnetic drifts are also found to yield a near-symmetric ELM power deposition on the inner and outer divertor target plates, consistent with experimental measurements. PMID:25659004

  1. Extended MHD Simulations of Spheromaks

    NASA Astrophysics Data System (ADS)

    Howell, E. C.; Sovinec, C. R.

    2012-10-01

    Nonlinear extended MHD simulations of a spheromak in a cylindrical flux conserver are performed using the NIMROD code (JCP 195, 2004). An idealized series of simulations starting from a Grad-Shafranov equilibrium and small non-axisymmetric perturbations are performed to model the sustained decay phase. The resulting confinement leads to steep resistivity gradients. Strong current gradients develop, driving tearing modes that dominate the evolution of the spheromak. Absent in these simulations are the remains of n=1 fluctuations created during the formation process. A second series of simulations start from vacuum fields and model the full spheromak evolution, including the formation process where the n=1 fluctuations dominate. To understand the role of pressure driven instabilities in the evolution of the spheromak, a numerical diagnostic is developed to calculate the Mercier stability criterion from the axisymmetric fields.

  2. MHD Energy Bypass Scramjet Engine

    NASA Technical Reports Server (NTRS)

    Mehta, Unmeel B.; Bogdanoff, David W.; Park, Chul; Arnold, Jim (Technical Monitor)

    2001-01-01

    Revolutionary rather than evolutionary changes in propulsion systems are most likely to decrease cost of space transportation and to provide a global range capability. Hypersonic air-breathing propulsion is a revolutionary propulsion system. The performance of scramjet engines can be improved by the AJAX energy management concept. A magneto-hydro-dynamics (MHD) generator controls the flow and extracts flow energy in the engine inlet and a MHD accelerator downstream of the combustor accelerates the nozzle flow. A progress report toward developing the MHD technology is presented herein. Recent theoretical efforts are reviewed and ongoing experimental efforts are discussed. The latter efforts also include an ongoing collaboration between NASA, the US Air Force Research Laboratory, US industry, and Russian scientific organizations. Two of the critical technologies, the ionization of the air and the MHD accelerator, are briefly discussed. Examples of limiting the combustor entrance Mach number to a low supersonic value with a MHD energy bypass scheme are presented, demonstrating an improvement in scramjet performance. The results for a simplified design of an aerospace plane show that the specific impulse of the MHD-bypass system is better than the non-MHD system and typical rocket over a narrow region of flight speeds and design parameters. Equilibrium ionization and non-equilibrium ionization are discussed. The thermodynamic condition of air at the entrance of the engine inlet determines the method of ionization. The required external power for non-equilibrium ionization is computed. There have been many experiments in which electrical power generation has successfully been achieved by magneto-hydrodynamic (MHD) means. However, relatively few experiments have been made to date for the reverse case of achieving gas acceleration by the MHD means. An experiment in a shock tunnel is described in which MHD acceleration is investigated experimentally. MHD has several

  3. Reduced Extended MHD

    NASA Astrophysics Data System (ADS)

    Morrison, P. J.; Abdelhamid, H. M.; Grasso, D.; Hazeltine, R. D.; Lingam, M.; Tassi, E.

    2015-11-01

    Over the years various reduced fluid models have been obtained for modeling plasmas, with the goal of capturing important physics while maintaining computability. Such models have included the physics contained in various generalizations of Ohm's law, including Hall drift and electron inertia. In a recent publication it was shown that full 3D extended MHD is a Hamiltonian system by finding its noncanonical Poisson bracket. Subsequently, this bracket was shown to be derivable from that for Hall MHD by a series of remarkable transformations, which greatly simplifies the proof of the Jacobi identity and allows one to immediately obtain generalizations of the helicity and cross helicity. In this poster we use this structure to obtain exact reduced fluid models with the effects of full two-fluid theory. Results of numerical computations of collisionless reconnection using an exact reduced 4-field model will be presented and analytical comparisons of mode structure of previous reduced models will be made.

  4. MHD properties of magnetosheath flow

    NASA Astrophysics Data System (ADS)

    Siscoe, G. L.; Crooker, N. U.; Erickson, G. M.; Sonnerup, B. U. Ö.; Maynard, N. C.; Schoendorf, J. A.; Siebert, K. D.; Weimer, D. R.; White, W. W.; Wilson, G. R.

    2002-04-01

    We discuss four aspects of magnetosheath flow that require MHD for their calculation and understanding. We illustrate these aspects with computations using a numerical MHD code that simulates the global magnetosphere and its magnetosheath. The four inherently MHD aspects of magnetosheath flow that we consider are the depletion layer, the magnetospheric sash, MHD flow deflections, and the magnetosheath's slow-mode expansion into the magnetotail. We introduce new details of these aspects or illustrate known details in a new way, including the dependence of the depletion layer on interplanetary magnetic filed clock angle; agreement between the locations of the antiparallel regions of Luhmann et al. (J. Geophys. Res. 89 (1984) 1739) and the magnetospheric sash, and deflections corresponding separately to a stagnation line and magnetic reconnection.

  5. Simulating solar MHD

    NASA Astrophysics Data System (ADS)

    Schüssler, M.

    1999-05-01

    Two aspects of solar MHD are discussed in relation to the work of the MHD simulation group at KIS. Photospheric magneto-convection, the nonlinear interaction of magnetic field and convection in a strongly stratified, radiating fluid, is a key process of general astrophysical relevance. Comprehensive numerical simulations including radiative transfer have significantly improved our understanding of the processes and have become an important tool for the interpretation of observational data. Examples of field intensification in the solar photosphere ('convective collapse') are shown. The second line of research is concerned with the dynamics of flux tubes in the convection zone, which has far-reaching implications for our understanding of the solar dynamo. Simulations indicate that the field strength in the region where the flux is stored before erupting to form sunspot groups is of the order of 105 G, an order of magnitude larger than previous estimates based on equipartition with the kinetic energy of convective flows.

  6. MHD Spectroscopy

    SciTech Connect

    Heeter, R F; Fasoli, A; Testa, D; Sharapov, S; Berk, H L; Breizman, B; Gondhalekar, A; Mantsinen, M

    2004-03-23

    Experiments are conducted on the JET tokamak to assess the diagnostic potential of MHD active and passive spectroscopy, for the plasma bulk and its suprathermal components, using Alfv{acute e}n Eigenmodes (AEs) excited by external antennas and by energetic particles. The measurements of AE frequencies and mode numbers give information on the bulk plasma. Improved equilibrium reconstruction, in particular in terms of radial profiles of density and safety factor, is possible from the comparison between the antenna driven spectrum and that calculated theoretically. Details of the time evolution of the non-monotonic safety factor profile in advanced scenarios can be reconstructed from the frequency of ICRH-driven energetic particle modes. The plasma effective mass can be inferred from the resonant frequency of externally driven AEs in discharges with similar equilibrium profiles. The stability thresholds and the nonlinear development of the instabilities can give clues on energy and spatial distribution of the fast particle population. The presence of unstable AEs provides lower limits in the energy of ICRH generated fast ion tails. Fast ion pressure gradients and their evolution can be inferred from the stability of AEs at different plasma radial positions. Finally, the details of the AE spectrum in the nonlinear stage can be used to obtain information about the fast particle velocity space diffusion.

  7. Output from MHD Models

    NASA Astrophysics Data System (ADS)

    Vlahakis, Nektarios

    2010-03-01

    Outflows emanating from the environment of stellar or galactic objects are a widespread phenomenon in astrophysics. Their morphology ranges from nearly spherically symmetric winds to highly collimated jets. In some cases, e.g., in jets associated with young stellar objects, the bulk outflow speeds are nonrelativistic, while in others, e.g., in jets associated with active galactic nuclei or gamma-ray bursts, it can even be highly relativistic. The main driving mechanism of collimated outflows is likely related to magnetic fields. These fields are able to tap the rotational energy of the compact object or disk, accelerate, and collimate matter ejecta. To zeroth order these outflows can be described by the highly intractable theory of magnetohydrodynamics (MHD). Even in systems where the assumptions of zero resistivity (ideal MHD), steady state, axisymmetry, one fluid description, and polytropic equation of state are applicable, the problem remains difficult. In this case the problem reduces to only two equations, corresponding to the two components of the momentum equation along the flow and in the direction perpendicular to the magnetic field (transfield direction). The latter equation is the most difficult to solve, but also the most important. It answers the question on the degree of the collimation, but also crucially affects the solution of the first, the acceleration efficiency and the bulk velocity of the flow. The first and second parts of this chapter refer to nonrelativistic and relativistic flows, respectively. These Parts can be read independently. In each one, the governing equations are presented and discussed, focusing on the case of flows that are magnetically dominated near the central source. The general characteristics of the solutions in relation to the acceleration and collimation mechanisms are analyzed. As specific examples of exact solutions of the full system of the MHD equations that satisfy all the analyzed general characteristics, self

  8. A family cluster of tuberculosis cases, including a case of acquired multidrug resistant tuberculosis.

    PubMed

    Holden, Julie; Trachtman, Louis

    2012-01-01

    Although the number of tuberculosis cases in the US is at an all-time low, with progressive declines seen for the past 17 years, many goals in the tuberculosis elimination process remain unrealized. This report describes a cluster of four tuberculosis cases in a family, including one case of acquired multidrug resistant tuberculosis. It also underscores some important issues in tuberculosis control today, including significant disparities in the foreign-born population with multidrug resistant tuberculosis as a looming problem, as well as utilization of therapeutic drug level monitoring in complicated cases. PMID:22533114

  9. Extended MHD Stabiliy Calculations of Spheromak Equilibria

    NASA Astrophysics Data System (ADS)

    Howell, E. C.; Sovinec, C. R.

    2013-10-01

    Linear extended MHD calculations of spheromak equilibria in a cylindrical flux conserver are performed using the NIMROD code (Sovinec et al., JCP 195, 2004). A series of Grad-Sharfranov equilibria are generated with β ranging from 0 . 4 % to 4 . 2 % , corresponding to peak electron temperatures ranging 50 to 300 eV. These equilibria use a λ profile representative of SSPX shot 14590, which measured a peak electron temperature of 325 eV (McLean et al., POP 13, 2006). Resistive MHD calculations find that the β = 0 . 4 % case is unstable to resonant resistive interchange modes with γτA <= 2 . 3 % . These modes transition to ideal interchange as the equilibrium pressure is increased. Growth rates as large as γτA = 20 % are calculated for the 4 . 2 % β case. Calculations including ion-gyroviscosity show a minimal reduction of growth rate. Effects from including the Hall and Electron pressure terms in Ohm's Law and the cross-field diamagnetic heat flux are investigated. Results of related nonlinear simulations are also presented. Work Supported by US DOE.

  10. MHD Power Generation

    ERIC Educational Resources Information Center

    Kantrowitz, Arthur; Rosa, Richard J.

    1975-01-01

    Explains the operation of the Magnetohydrodynamic (MHD) generator and advantages of the system over coal, oil or nuclear powered generators. Details the development of MHD generators in the United States and Soviet Union. (CP)

  11. Chemical solver to compute molecule and grain abundances and non-ideal MHD resistivities in prestellar core-collapse calculations

    NASA Astrophysics Data System (ADS)

    Marchand, P.; Masson, J.; Chabrier, G.; Hennebelle, P.; Commerçon, B.; Vaytet, N.

    2016-07-01

    We develop a detailed chemical network relevant to calculate the conditions that are characteristic of prestellar core collapse. We solve the system of time-dependent differential equations to calculate the equilibrium abundances of molecules and dust grains, with a size distribution given by size-bins for these latter. These abundances are used to compute the different non-ideal magneto-hydrodynamics resistivities (ambipolar, Ohmic and Hall), needed to carry out simulations of protostellar collapse. For the first time in this context, we take into account the evaporation of the grains, the thermal ionisation of potassium, sodium, and hydrogen at high temperature, and the thermionic emission of grains in the chemical network, and we explore the impact of various cosmic ray ionisation rates. All these processes significantly affect the non-ideal magneto-hydrodynamics resistivities, which will modify the dynamics of the collapse. Ambipolar diffusion and Hall effect dominate at low densities, up to nH = 1012 cm-3, after which Ohmic diffusion takes over. We find that the time-scale needed to reach chemical equilibrium is always shorter than the typical dynamical (free fall) one. This allows us to build a large, multi-dimensional multi-species equilibrium abundance table over a large temperature, density and ionisation rate ranges. This table, which we make accessible to the community, is used during first and second prestellar core collapse calculations to compute the non-ideal magneto-hydrodynamics resistivities, yielding a consistent dynamical-chemical description of this process. The multi-dimensional multi-species equilibrium abundance table and a copy of the code are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/592/A18

  12. Magnetohydrodynamic (MHD) channel corner seal

    DOEpatents

    Spurrier, Francis R.

    1980-01-01

    A corner seal for an MHD duct includes a compressible portion which contacts the duct walls and an insulating portion which contacts the electrodes, sidewall bars and insulators. The compressible portion may be a pneumatic or hydraulic gasket or an open-cell foam rubber. The insulating portion is segmented into a plurality of pieces of the same thickness as the electrodes, insulators and sidewall bars and aligned therewith, the pieces aligned with the insulator being of a different size from the pieces aligned with the electrodes and sidewall bars to create a stepped configuration along the corners of the MHD channel.

  13. Cometary MHD and chemistry

    NASA Technical Reports Server (NTRS)

    Wegmann, R.; Schmidt, H. U.; Huebner, W. F.; Boice, D. C.

    1987-01-01

    An MHD and chemical comet-coma model was developed, applying the computer program of Huebner (1985) for the detailed chemical evolution of a spherically expanding coma and the program of Schmidt and Wegman (1982) and Wegman (1987) for the MHD flow of plasma and magnetic field in a comet to the Giotto-mission data on the ion abundances measured by the HIS ion mass spectrometer. The physics and chemistry of the coma are modeled in great detail, including photoprocesses, gas-phase chemical kinetics, energy balance with a separate electron temperature, multifluid hydrodynamics with a transition to free molecular flow, fast-streaming atomic and molecular hydrogen, counter and cross streaming of the ionized species relative to the neutral species in the coma-solar wind interaction region with momentum exchange by elastic collisions, mass-loading through ion pick-up, and Lorentz forces of the advected magnetic field. The results, both inside and outside of the contact surface, are discussed and compared with the relevant HIS ion mass spectra.

  14. Simulating solar MHD

    NASA Astrophysics Data System (ADS)

    Schüssler, M.

    1999-05-01

    Two aspects of solar MHD are discussed in relation to the work of the MHD simulation group at KIS. Photospheric magneto-convection, the nonlinear interaction of magnetic field and convection in a strongly stratified, radiating fluid, is a key process of general astrophysical relevance. Comprehensive numerical simulations including radiative transfer have significantly improved our understanding of the processes and have become an important tool for the interpretation of observational data. Examples of field intensification in the solar photosphere ('convective collapse') are shown. The second line of research is concerned with the dynamics of flux tubes in the convection zone, which has far-reaching implications for our understanding of the solar dynamo. Simulations indicate that the field strength in the region where the flux is stored before erupting to form sunspot groups is of the order of 105 G, an order of magnitude larger than previous estimates based on equipartition with the kinetic energy of convective flows.Key words. Solar physics · astrophysics and astronomy (photosphere and chromosphere; stellar interiors and dynamo theory; numerical simulation studies).

  15. Drug-resistant tuberculosis in subjects included in the Second National Survey on Antituberculosis Drug Resistance in Porto Alegre, Brazil*, **

    PubMed Central

    Micheletti, Vania Celina Dezoti; Moreira, José da Silva; Ribeiro, Marta Osório; Kritski, Afranio Lineu; Braga, José Ueleres

    2014-01-01

    OBJECTIVE: To describe the prevalence of multidrug-resistant tuberculosis (MDR-TB) among tuberculosis patients in a major Brazilian city, evaluated via the Second National Survey on Antituberculosis Drug Resistance, as well as the social, demographic, and clinical characteristics of those patients. METHODS: Clinical samples were collected from tuberculosis patients seen between 2006 to 2007 at three hospitals and five primary health care clinics participating in the survey in the city of Porto Alegre, Brazil. The samples were subjected to drug susceptibility testing. The species of mycobacteria was confirmed using biochemical methods. RESULTS: Of the 299 patients included, 221 (73.9%) were men and 77 (27.3%) had a history of tuberculosis. The mean age was 36 years. Of the 252 patients who underwent HIV testing, 66 (26.2%) tested positive. The prevalence of MDR-TB in the sample as a whole was 4.7% (95% CI: 2.3-7.1), whereas it was 2.2% (95% CI: 0.3-4.2) among the new cases of tuberculosis and 12.0% (95% CI: 4.5-19.5) among the patients with a history of tuberculosis treatment. The multivariate analysis showed that a history of tuberculosis and a longer time to diagnosis were both associated with MDR-TB. CONCLUSIONS: If our results are corroborated by other studies conducted in Brazil, a history of tuberculosis treatment and a longer time to diagnosis could be used as predictors of MDR-TB. PMID:24831400

  16. MHD integrated topping cycle project

    NASA Astrophysics Data System (ADS)

    1992-01-01

    The overall objective of the project is to design and construct prototypical hardware for an integrated MHD topping cycle, and conduct long duration proof-of-concept tests of integrated system at the US DOE Component Development and Integration Facility in Butte, Montana. The results of the long duration tests will augment the existing engineering design data base on MHD power train reliability, availability, maintainability, and performance, and will serve as a basis for scaling up the topping cycle design to the next level of development, an early commercial scale power plant retrofit. The components of the MHD power train to be designed, fabricated, and tested include: A slagging coal combustor with a rated capacity of 50 MW thermal input, capable of operation with an Eastern (Illinois no. 6) or Western (Montana Rosebud) coal, a segmented supersonic nozzle, a supersonic MHD channel capable of generating at least 1.5 MW of electrical power, a segmented supersonic diffuser section to interface the channel with existing facility quench and exhaust systems, a complete set of current control circuits for local diagonal current control along the channel, and a set of current consolidation circuits to interface the channel with the existing facility inverter.

  17. MHD Integrated Topping Cycle Project

    SciTech Connect

    Not Available

    1992-01-01

    The overall objective of the project is to design and construct prototypical hardware for an integrated MHD topping cycle, and conduct long duration proof-of-concept tests of integrated system at the US DOE Component Development and Integration Facility in Butte, Montana. The results of the long duration tests will augment the existing engineering design data base on MHD power train reliability, availability, maintainability, and performance, and will serve as a basis for scaling up the topping cycle design to the next level of development, an early commercial scale power plant retrofit. The components of the MHD power train to be designed, fabricated, and tested include: A slagging coal combustor with a rated capacity of 50 MW thermal input, capable of operation with an Eastern (Illinois {number sign}6) or Western (Montana Rosebud) coal, a segmented supersonic nozzle, a supersonic MHD channel capable of generating at least 1.5 MW of electrical power, a segmented supersonic diffuser section to interface the channel with existing facility quench and exhaust systems, a complete set of current control circuits for local diagonal current control along the channel, and a set of current consolidation circuits to interface the channel with the existing facility inverter.

  18. MHD Technology Transfer, Integration and Review Committee

    SciTech Connect

    Not Available

    1989-10-01

    As part of the MHD Integrated Topping Cycle (ITC) project, TRW was given the responsibility to organize, charter and co-chair, with the Department of Energy (DOE), an MHD Technology Transfer, Integration and Review Committee (TTIRC). The Charter of the TTIRC, which was approved by the DOE in June 1988 and distributed to the committee members, is included as part of this Summary. As stated in the Charter, the purpose of this committee is to: (1) review all Proof-of-Concept (POC) projects and schedules in the national MHD program; to assess their compatibility with each other and the first commercial MHD retrofit plant; (2) establish and implement technology transfer formats for users of this technology; (3) identify interfaces, issues, and funding structures directly impacting the success of the commercial retrofit; (4) investigate and identify the manner in which, and by whom, the above should be resolved; and (5) investigate and assess other participation (foreign and domestic) in the US MHD Program. The DOE fiscal year 1989 MHD Program Plan Schedule is included at the end of this Summary. The MHD Technology Transfer, Integration and Review Committee's activities to date have focused primarily on the technology transfer'' aspects of its charter. It has provided a forum for the dissemination of technical and programmatic information among workers in the field of MHD and to the potential end users, the utilities, by holding semi-annual meetings. The committee publishes this semi-annual report, which presents in Sections 2 through 11 capsule summaries of technical progress for all DOE Proof-of-Concept MHD contracts and major test facilities.

  19. Magnetic reconnection in a compressible MHD plasma

    SciTech Connect

    Hesse, Michael; Zenitani, Seiji; Birn, Joachim

    2011-04-15

    Using steady-state resistive MHD, magnetic reconnection is reinvestigated for conditions of high resistivity/low magnetic Reynolds number, when the thickness of the diffusion region is no longer small compared to its length. Implicit expressions for the reconnection rate and other reconnection parameters are derived based on the requirements of mass, momentum, and energy conservation. These expressions are solved via simple iterative procedures. Implications specifically for low Reynolds number/high resistivity are being discussed.

  20. MHD Wave in Sunspots

    NASA Astrophysics Data System (ADS)

    Sych, Robert

    2016-02-01

    The study of magnetohydrodynamic (MHD) waves and oscillations in the solar atmosphere is one of the fastest developing fields in solar physics, and lies in the mainstream of using solar instrumentation data. This chapter first addresses the spatial frequency morphology of sources of sunspot oscillations and waves, including their localization, size, oscillation periods, and height localization with the mechanism of cutoff frequency that forms the observed emission variability. Then, it presents a review dynamic of sunspot wave processes, provides the information about the structure of wave fronts and their time variations, and investigates the oscillation frequency transformation depending on the wave energy. The chapter also addresses the initializing solar flares caused by trigger agents like magnetoacoustic waves, accelerated particle beams, and shocks. Special attention is paid to the relation between the flare reconnection periodic initialization and the dynamics of sunspot slow magnetoacoustic waves.

  1. MHD Turbulence and Magnetic Dynamos

    NASA Technical Reports Server (NTRS)

    Shebalin, John V

    2014-01-01

    Incompressible magnetohydrodynamic (MHD) turbulence and magnetic dynamos, which occur in magnetofluids with large fluid and magnetic Reynolds numbers, will be discussed. When Reynolds numbers are large and energy decays slowly, the distribution of energy with respect to length scale becomes quasi-stationary and MHD turbulence can be described statistically. In the limit of infinite Reynolds numbers, viscosity and resistivity become zero and if these values are used in the MHD equations ab initio, a model system called ideal MHD turbulence results. This model system is typically confined in simple geometries with some form of homogeneous boundary conditions, allowing for velocity and magnetic field to be represented by orthogonal function expansions. One advantage to this is that the coefficients of the expansions form a set of nonlinearly interacting variables whose behavior can be described by equilibrium statistical mechanics, i.e., by a canonical ensemble theory based on the global invariants (energy, cross helicity and magnetic helicity) of ideal MHD turbulence. Another advantage is that truncated expansions provide a finite dynamical system whose time evolution can be numerically simulated to test the predictions of the associated statistical mechanics. If ensemble predictions are the same as time averages, then the system is said to be ergodic; if not, the system is nonergodic. Although it had been implicitly assumed in the early days of ideal MHD statistical theory development that these finite dynamical systems were ergodic, numerical simulations provided sufficient evidence that they were, in fact, nonergodic. Specifically, while canonical ensemble theory predicted that expansion coefficients would be (i) zero-mean random variables with (ii) energy that decreased with length scale, it was found that although (ii) was correct, (i) was not and the expected ergodicity was broken. The exact cause of this broken ergodicity was explained, after much

  2. HYBRID AND HALL-MHD SIMULATIONS OF COLLISIONLESS RECONNECTION: EFFECTS OF PLASMA PRESSURE TENSOR

    SciTech Connect

    L. YIN; D. WINSKE; ET AL

    2001-05-01

    In this study we performed two-dimensional hybrid (particle ions, massless fluid electrons) and Hall-MHD simulations of collisionless reconnection in a thin current sheet. Both calculations include the full electron pressure tensor (instead of a localized resistivity) in the generalized Ohm's law to initiate reconnection, and in both an initial perturbation to the Harris equilibrium is applied. First, electron dynamics from the two calculations are compared, and we find overall agreement between the two calculations in both the reconnection rate and the global configuration. To address the issue of how kinetic treatment for the ions affects the reconnection dynamics, we compared the fluid-ion dynamics from the Hall-MHD calculation to the particle-ion dynamics obtained from the hybrid simulation. The comparison demonstrates that off-diagonal elements of the ion pressure tensor are important in correctly modeling the ion out-of-plane momentum transport from the X point. It is that these effects can be modeled efficiently using a particle Hall-MHD simulation method in which particle ions used in a predictor/corrector to implement the ion gyro-radius corrections. We also investigate the micro- macro-scale coupling in the magnetotail dynamics by using a new integrated approach in which particle Hall-MHD calculations are embedded inside a MHD simulation. Initial results of the simulation concerning current sheet thinning and reconnection dynamics are discussed.

  3. Simulation of thermal reset transitions in resistive switching memories including quantum effects

    SciTech Connect

    Villena, M. A.; Jiménez-Molinos, F.; Roldán, J. B.; Suñé, J.; Miranda, E.; Romera, E.

    2014-06-07

    An in-depth study of reset processes in RRAMs (Resistive Random Access Memories) based on Ni/HfO{sub 2}/Si-n{sup +} structures has been performed. To do so, we have developed a physically based simulator where both ohmic and tunneling based conduction regimes are considered along with the thermal description of the devices. The devices under study have been successfully fabricated and measured. The experimental data are correctly reproduced with the simulator for devices with a single conductive filament as well as for devices including several conductive filaments. The contribution of each conduction regime has been explained as well as the operation regimes where these ohmic and tunneling conduction processes dominate.

  4. Resistance Gene Analogs in Rosaceae: Family-wide Classification Including Raspberry, Cherry, and Wild Apples

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Genetic studies have shown that NBS-LRR Resistance Gene Analogs (RGAs)tend to occur in clusters and often map to major resistance genes or QTLs. The identification and use of specific RGAs as molecular markers among plant material displaying different resistance phenotypes has the potential to direc...

  5. Open Boundary Conditions for Dissipative MHD

    SciTech Connect

    Meier, E T

    2011-11-10

    In modeling magnetic confinement, astrophysics, and plasma propulsion, representing the entire physical domain is often difficult or impossible, and artificial, or 'open' boundaries are appropriate. A novel open boundary condition (BC) for dissipative MHD, called Lacuna-based open BC (LOBC), is presented. LOBC, based on the idea of lacuna-based truncation originally presented by V.S. Ryaben'kii and S.V. Tsynkov, provide truncation with low numerical noise and minimal reflections. For hyperbolic systems, characteristic-based BC (CBC) exist for separating the solution into outgoing and incoming parts. In the hyperbolic-parabolic dissipative MHD system, such separation is not possible, and CBC are numerically unstable. LOBC are applied in dissipative MHD test problems including a translating FRC, and coaxial-electrode plasma acceleration. Solution quality is compared to solutions using CBC and zero-normal derivative BC. LOBC are a promising new open BC option for dissipative MHD.

  6. Hospital Isolates of Serratia marcescens Transferring Ampicillin, Carbenicillin, and Gentamicin Resistance to Other Gram-Negative Bacteria Including Pseudomonas aeruginosa

    PubMed Central

    Olexy, Vera M.; Bird, Thomas J.; Grieble, Hans G.; Farrand, Stephen K.

    1979-01-01

    Thirteen independent isolates of Serratia marcescens associated with nosocomial urinary tract infections were obtained from the clinical microbiology laboratory at Hines Veterans Administration Hospital. The isolates were resistant to at least ampicillin, carbenicillin, gentamicin, and tobramycin. They could be divided into two groups on the basis of their antibiotypes. Group I (9 strains) showed resistance to 13 antibiotics, including 3 beta-lactams, 6 aminoglycosides, tetracycline, sulfonamide, trimethoprim, and polymyxin B. Group II (4 strains) was resistant to 11 antibiotics, including 3 beta-lactams, 5 aminoglycosides, sulfonamide, trimethoprim, and polymyxin B. Donors from both groups transferred resistance traits to Escherichia coli. Transconjugants from matings with group II donors all acquired resistance to nine antibiotics, including the three beta-lactams, five aminoglycosides, and sulfonamide. Transconjugants from matings with group I donors were of varied antibiotypes, inheriting resistance to up to 11 of the 13 antibiotics. Resistances to trimethoprim and polymyxin B were never observed to transfer. E. coli transconjugants of each group were capable of transferring multiple-antibiotic resistance to several other members of the family Enterobacteriaceae. All group II S. marcescens and E. coli donors and all group I S. marcescens donors transferred carbenicillin, streptomycin, kanamycin, gentamicin, tobramycin, and sisomicin resistance to Pseudomonas aeruginosa. The results suggest that these S. marcescens strains harbor R factors of a broader host range than previously reported. PMID:106772

  7. Investigation of multiple roots of the resistive wall mode dispersion relation, including kinetic effects

    SciTech Connect

    Berkery, J. W.; Sabbagh, S. A.; Betti, R.

    2011-07-15

    The resistive wall mode instability in tokamak plasmas has a complex frequency which can be determined by a dispersion relation that is cubic, in general, leading to three distinct roots. A simplified model of the dispersion relation, including kinetic effects, is presented and used to explore the behavior of these roots. By changing the plasma rotation frequency, it is shown that one root has a slow mode rotation frequency (less than the inverse wall time) while the other two rotate more quickly, one leading and one lagging the plasma rotation frequency. When realistic experimental parameters from the National Spherical Torus Experiment [M. Ono et al., Nucl. Fusion 40, 557 (2000)] are used, however, only one slow rotating, near-marginal stability root is found, consistent with present experiments and more detailed calculations with the MISK code [B. Hu et al., Phys. Plasmas 12, 057301 (2005)]. Electron collisionality acts to stabilize one of the rotating roots, while ion collisionality can stabilize the other. In devices with low rotation and low collisionality, these two rotating roots may manifest themselves, but they are likely to remain stable.

  8. Activity of faropenem tested against Neisseria gonorrhoeae isolates including fluoroquinolone-resistant strains.

    PubMed

    Jones, Ronald N; Critchley, Ian A; Whittington, William L H; Janjic, Nebojsa; Pottumarthy, Sudha

    2005-12-01

    We evaluated the anti-gonococcal potency of faropenem along with 7 comparator reference antimicrobials against a preselected collection of clinical isolates. The 265 isolates were inclusive of 2 subsets: 1) 76 well-characterized resistant phenotypes of gonococcal strains (53 quinolone-resistant strains--31 with documented quinolone resistance-determining region changes from Japan, 15 strains resistant to penicillin and tetracycline, and 8 strains with intermediate susceptibility to penicillin) and 2) 189 recent isolates from clinical specimens in 2004 from 6 states across the United States where quinolone resistance is prevalent. Activity of faropenem was adversely affected by l-cysteine hydrochloride in IsoVitaleX (4-fold increase in [minimal inhibitory concentration] MIC50; 0.06 versus 0.25 microg/mL). The rank order of potency of the antimicrobials for the entire collection was ceftriaxone (MIC90, 0.06 microg/mL) > faropenem (0.25 microg/mL) > azithromycin (0.5 microg/mL) > cefuroxime (1 microg/mL) > tetracycline (2 microg/mL) > penicillin = ciprofloxacin = levofloxacin (4 microg/mL). Using MIC90 for comparison, faropenem was 4-fold more potent than cefuroxime (0.25 versus 1 microg/mL), but was 4-fold less active than ceftriaxone (0.25 versus 0.06 microg/mL). Although the activity of faropenem was not affected by either penicillinase production (MIC90, 0.12 microg/mL, penicillinase-positive) or increasing ciprofloxacin MIC (0.25 microg/mL, ciprofloxacin-resistant), increasing penicillin MIC was associated with an increase in MIC90 values (0.016 microg/mL for penicillin-susceptible to 0.25 microg/mL for penicillin-resistant strains). Among the recent (2004) clinical gonococcal isolates tested, reduced susceptibility to penicillins, tetracycline, and fluoroquinolones was high (28.0-94.2%). Geographic distribution of the endemic resistance rates of gonococci varied considerably, with 16.7-66.7% of the gonococcal isolates being ciprofloxacin-resistant in Oregon

  9. Antibiotic sensitivity of Haemophilus influenzae strains including three recent chloramphenicol-resistant isolates.

    PubMed

    Zackrisson, G; Brorson, J E

    1980-08-01

    The antibiotic sensitivity of 100 recent isolates of Haemophilus influenzae was determined. Three strains were resistant to chloramphenicol with minimal inhibitory concentrations of 16 microgram/ml. Of these three resistant strains, one produced betalactamase and one was resistant to sulfamethoxazole-trimethoprim. The remaining strains were inhibited by 0.25-2.0 microgram/ml of chloramphenicol. Ampicillin and benzylpenicillin were found to inhibit all but the betalactamase-producing strains at low concentrations. Regarding sulfamethoxazole-trimethoprim 96% had minimal inhibitory concentrations of 2.5-0.12 microgram/ml or less, while two strains were resistant. The invitro efficacy of erythromycin against H. influenzae was low. The majority of the strains was inhibited by low concentrations of doxycycline and cefuroxime while cefoxitin exhibited minimal inhibitory concentrations values usually exceeding 1 microgram/ml. The minimal inhibitory concentrations registered are compared to the concentrations of the different antibiotics attainable in certain body fluids. PMID:6968146

  10. MHD Contractors' Review Meeting: Abstracts

    NASA Astrophysics Data System (ADS)

    The objectives of the Integrated Topping Cycle project are to design, construct, and deliver all prototypical hardware necessary to conduct long duration integrated MHD topping cycle proof-of-concept tests at the Component Development and Integration Facility (CDIF) in Butte, Montana. The results of the long duration tests will augment the existing engineering data base on MHD power train reliability, maintainability, durability, and performance, and will serve as a basis for scaling up to the early commercial scale power plant retrofit. The components of the MHD power train to be designed, fabricated, and tested include the following three systems: (1) a slagging coal combustion subsystem with a rated capacity of 50 MW thermal input, capable of operation with eastern (Illinois) or western (Montana Rosebud) coal; (2) a channel subsystem consisting of a segmented supersonic nozzle, channel (with current controls), and diffuser, capable of power output of 1.5 MW(sub e); and (3) a current consolidation subsystem to interface the channel with the existing facility inverter.

  11. Advances in the theory and application of BSF cells. [including electrical resistivity and photovoltaic cells

    NASA Technical Reports Server (NTRS)

    Mandelkorn, J.; Lamneck, J. H.

    1975-01-01

    The characteristics and behavior of p(+), p solar cells were investigated. The p(+), p cells were made by the removal of the n(+) surface layers from n(+), p p(+), BSF cells followed by application of a suitable contact to the resultant p(+), p structures. The open circuit voltage of p(+), p cells was found to increase with increasing 'p' bulk resistivity. The measured open circuit velocity-temperature coefficients were positive and increased with increasing resistivity. An outline of prior limitations in solar cell design is presented, and the removal of these limitations through use of BSF effects is pointed out. The study of BSF effects made feasible production of very thin high efficiency silicon cells as well as high resistivity-high efficiency cells, two desirable types of silicon cells which were previously impossible to make.

  12. Industrial applications of MHD high temperature air heater technology

    NASA Astrophysics Data System (ADS)

    Saari, D. P.; Fenstermacher, J. E.; White, L. R.; Marksberry, C. L.

    1981-12-01

    The MHD high temperature air heater (HTAH) requires technology beyond the current state-of-the-art of industrial regenerative heaters. Specific aspects of HTAH technology which may find other application include refractory materials and valves resistant to the high temperature, corrosive, slag-bearing gas, materials resistant to cyclic thermal stresses, high temperature support structures for the cored brick bed, regenerative heater operating techniques for preventing accumulation of slag in the heater, and analytical tools for computing regenerative heater size, cost, and performance. Areas where HTAH technology may find application include acetylene/ethylene production processes, flash pyrolysis of coal, high temperature gas reactors, coal gasification processes, various metallurgical processes, waste incineration, and improvements to existing regenerator technology such as blast furnace stoves and glass tank regenerators.

  13. Computation of the MHD modes with rotation and kinetic effects: AEGIS

    NASA Astrophysics Data System (ADS)

    Zheng, L.-J.; Kotschenreuther, M.; Turnbull, A.; Waelbroeck, F.; van Dam, J. W.; Berk, H.

    2003-10-01

    A new linear MHD eigenvalue code called AEGIS (Adaptive EiGenfunction Independent Shooting) is being developed at the IFS. The benchmarking of AEGIS with GATO is underway and will be presented. Plasma rotation is being included, with the effect of rotation-enhanced plasma compressibility also taken into account. As a first step in including rotational effects, the ideal MHD model is being employed. Details of the numerical scheme will be described, along with preliminary numerical results. The plan to include kinetic compressiblity will be discussed. With this new code, rotational stabilization of resistive wall modes can be rigorously calculated for the first time. The algorithm also allows FLR effects to be included. Many helpful suggestions from A. Glasser are acknowledged.

  14. Activity of tigecycline tested against a global collection of Enterobacteriaceae, including tetracycline-resistant isolates.

    PubMed

    Fritsche, Thomas R; Strabala, Patty A; Sader, Helio S; Dowzicky, Michael J; Jones, Ronald N

    2005-07-01

    Steadily increasing resistance among the Enterobacteriaceae to beta-lactams, fluoroquinolones, aminoglycosides, tetracyclines, and trimethoprim/sulfamethoxazole has compromised the utility of these commonly used antimicrobial classes for many community- or hospital-acquired infections. The development of tigecycline, the sentinel representative of a novel class of broad-spectrum agents (the glycylcyclines), represents an important milestone in addressing this critical need. Resistance to tigecycline might be expected to occur via the same mechanisms that produce tetracycline resistance; however, tigecycline remains stable and largely unaffected by the commonly occurring efflux and ribosomal protection resistance mechanisms. In this study, an international collection of Enterobacteriaceae (11327 isolates; 32.8% tetracycline-resistant) from global surveillance studies (2000-2004) were evaluated against tigecycline and other comparator antimicrobials. Although the most active agents were the carbapenems and aminoglycosides (97.5-99.7% susceptible), tigecycline displayed high potency (MIC50 and MIC90, 0.25 and 1 microg/mL) with 95.7% of all strains being inhibited at < or =2 microg/mL. Despite higher MIC values observed with Serratia spp. and Proteae, between 90.5% and 97.5% of isolates were inhibited by < or =4 microg/mL of tigecycline. Tetracycline-resistant populations demonstrated only modest decreases in potency to tigecycline, which appeared to be species-dependent (up to 2-fold only for Escherichia coli, Salmonella spp., Shigella spp., and Panteoa agglomerans; and up to 4-fold for Klebsiella spp., Enterobacter spp., and Citrobacter spp.). Among E. coli (263 isolates) and Klebsiella spp. (356) that meet recognized screening definitions for extended-spectrum beta-lactamase production, 100.0% and 94.4% were inhibited by tigecycline at 2 microg/mL, respectively. These findings confirm that tigecycline exhibits potency, breadth of spectrum, and stability to the

  15. Proteomic and metabolic analyses of early berry development in Vitis spp. including the period of ontogenic gain of resistance

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Early development of grape berries is marked by several biological changes, including cell division and expansion, as berries initiate double sigmoid growth. In most genotypes, a significant gain of ontogenic resistance (OR) to some pathogens, including powdery mildew (PM) (Uncinula necator), also o...

  16. Survey of MHD plant applications

    NASA Technical Reports Server (NTRS)

    Lynch, J. J.; Seikel, G. R.; Cutting, J. C.

    1979-01-01

    Open-cycle MHD is one of the major R&D efforts in the Department of Energy's program to meet the national goal of reducing U.S. dependence on oil through increased utilization of coal. MHD offers an effective way to use coal to produce electric power at low cost in a highly efficient and environmentally acceptable manner. Open-cycle MHD plants are categorized by the MHD combustor oxidizer, its temperature and the method of preheat. The paper discusses MHD baseline plant design, open-cycle MHD plant in the Energy Conversion Alternatives Study (ECAS), early commercial MHD plants, conceptual studies of the engineering test facility, retrofit (addition of an MHD topping cycle to an existing steam plant), and other potential applications and concepts. Emphasis is placed on a survey of both completed and ongoing studies to define both commercial and pilot plant design, cost, and performance.

  17. Theoretical analysis on polarization-induced resistance switching effects of polymer thin films including dead layers

    NASA Astrophysics Data System (ADS)

    Honmi, Hitoshi; Hashizume, Yoichiro; Nakajima, Takashi; Okamura, Soichiro

    2015-10-01

    Polarization-induced resistance switching effects are analytically investigated. The electrostatic potential profile in metal is expressed by the Thomas-Fermi screening theory at the metal/ferroelectric interface. We estimate the current density using an assumed effective potential in metal/ferroelectric/metal junctions. Furthermore, we focus on the existence of a lower permittivity region such as a “dead layer” located at the boundary between the metal electrode and the ferroelectric material. In order to explain the ON/OFF ratio obtained in the experiment, we suggest that the dead layer near the smaller-work-function electrode side should be thicker by 2-3 Å than another electrode. Consequently, we propose a new hypothesis, that is, the thickness of the dead layer controls the ratio of resistance switching.

  18. Including dietary fiber and resistant starch to increase satiety and reduce aggression in gestating sows.

    PubMed

    Sapkota, A; Marchant-Forde, J N; Richert, B T; Lay, D C

    2016-05-01

    Aggression during mixing of pregnant sows impacts sow welfare and productivity. The aim of this study was to increase satiety and reduce aggression by including dietary fiber and fermentable carbohydrates. Sows were housed in individual stalls 7 to 14 d after breeding (moving day was considered d 0 of treatment) and were fed (at 0700 h) with a CONTROL (corn-soybean meal based with no additional fiber sources), RSTARCH (10.8% resistant starch), BEETPULP (27.2% sugar beet pulp), SOYHULLS (19.1% soybean hulls), or INCSOY (14.05% soybean hulls) for 21 d (5 sows/diet × 5 diets × 8 replications = 200 sows). The CONTROL diet was targeted to contain 185 g(d∙sow) NDF and the other diets were targeted to contain 350 g(d∙sow) NDF. The INCSOY diet was fed at 2.2 kg/(d∙sow) and the other diets were fed at 2 kg(d∙sow). On d 22, sows were mixed in groups of 5 (at 1200 h). Behaviors in stalls (on d 1, 7, 14, and 21) and after mixing (d 22 and 23), heart rate (on d 1, 7, 14, and 21), blood metabolites (on d 2, 8, 15, 22, and 25), and the effects of diets on production were collected and analyzed. Sows stood more ( < 0.01) and rested less ( < 0.001) over time irrespective of the diet. Sows on BEETPULP stood more ( < 0.01) and sows on SOYHULLS rested more ( < 0.01). Sham chewing increased over days irrespective of the diet. Chewing behavior (bar and feeder) increased with days on diet ( < 0.001) and was lowest in sows on the SOYHULLS diet ( = 0.045). When mixed, biting frequency in the first hour was highest for sows on the CONTROL diet (236.5 ± 62.6) and lowest for sows on the RSTARCH diet (90.5 ± 30.5). Skin lesions increased ( < 0.001) 24 h after mixing sows irrespective of diet. Blood urea nitrogen (BUN) concentration was lowest in sows fed BEETPULP and SOYHULLS ( < 0.001). Serum glucose concentration was highest in sows fed RSTARCH and BEETPULP ( = 0.04), but there was no day effect ( = 0.62) or diet × day interaction ( = 0.60). The NEFA was greatest in sows fed

  19. Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats.

    PubMed

    Solberg Woods, Leah C; Holl, Katie L; Oreper, Daniel; Xie, Yuying; Tsaih, Shirng-Wern; Valdar, William

    2012-11-01

    Type 2 diabetes (T2D) is a disease of relative insulin deficiency resulting from both insulin resistance and beta cell failure. We have previously used heterogeneous stock (HS) rats to fine-map a locus for glucose tolerance. We show here that glucose intolerance in the founder strains of the HS colony is mediated by different mechanisms: insulin resistance in WKY and an insulin secretion defect in ACI, and we demonstrate a high degree of variability for measures of insulin resistance and insulin secretion in HS rats. As such, our goal was to use HS rats to fine-map several diabetes-related traits within a region on rat chromosome 1. We measured blood glucose and plasma insulin levels after a glucose tolerance test in 782 male HS rats. Using 97 SSLP markers, we genotyped a 68 Mb region on rat chromosome 1 previously implicated in glucose and insulin regulation. We used linkage disequilibrium mapping by mixed model regression with inferred descent to identify a region from 198.85 to 205.9 that contains one or more quantitative trait loci (QTL) for fasting insulin and a measure of insulin resistance, the quantitative insulin sensitivity check index. This region also encompasses loci identified for fasting glucose and Insulin_AUC (area under the curve). A separate <3 Mb QTL was identified for body weight. Using a novel penalized regression method we then estimated effects of alternative haplotype pairings under each locus. These studies highlight the utility of HS rats for fine-mapping genetic loci involved in the underlying causes of T2D. PMID:22947656

  20. Accurate expressions for solar cell fill factors including series and shunt resistances

    NASA Astrophysics Data System (ADS)

    Green, Martin A.

    2016-02-01

    Together with open-circuit voltage and short-circuit current, fill factor is a key solar cell parameter. In their classic paper on limiting efficiency, Shockley and Queisser first investigated this factor's analytical properties showing, for ideal cells, it could be expressed implicitly in terms of the maximum power point voltage. Subsequently, fill factors usually have been calculated iteratively from such implicit expressions or from analytical approximations. In the absence of detrimental series and shunt resistances, analytical fill factor expressions have recently been published in terms of the Lambert W function available in most mathematical computing software. Using a recently identified perturbative relationship, exact expressions in terms of this function are derived in technically interesting cases when both series and shunt resistances are present but have limited impact, allowing a better understanding of their effect individually and in combination. Approximate expressions for arbitrary shunt and series resistances are then deduced, which are significantly more accurate than any previously published. A method based on the insights developed is also reported for deducing one-diode fits to experimental data.

  1. Mitomycin Resistance in Streptomyces lavendulae Includes a Novel Drug-Binding-Protein-Dependent Export System

    PubMed Central

    Sheldon, Paul J.; Mao, Yingqing; He, Min; Sherman, David H.

    1999-01-01

    Sequence analysis of Streptomyces lavendulae NRRL 2564 chromosomal DNA adjacent to the mitomycin resistance locus mrd (encoding a previously described mitomycin-binding protein [P. Sheldon, D. A. Johnson, P. R. August, H.-W. Liu, and D. H. Sherman, J. Bacteriol. 179:1796–1804, 1997]) revealed a putative mitomycin C (MC) transport gene (mct) encoding a hydrophobic polypeptide that has significant amino acid sequence similarity with several actinomycete antibiotic export proteins. Disruption of mct by insertional inactivation resulted in an S. lavendulae mutant strain that was considerably more sensitive to MC. Expression of mct in Escherichia coli conferred a fivefold increase in cellular resistance to MC, led to the synthesis of a membrane-associated protein, and correlated with reduced intracellular accumulation of the drug. Coexpression of mct and mrd in E. coli resulted in a 150-fold increase in resistance, as well as reduced intracellular accumulation of MC. Taken together, these data provide evidence that MRD and Mct function as components of a novel drug export system specific to the mitomycins. PMID:10198016

  2. Antimicrobial Susceptibility Pattern of Methicillin-Resistance Staphylococcus aureus from Different Tertiary Care Hospitals Including Mymensingh Medical College Hospital.

    PubMed

    Roy, S; Hossain, M A; Paul, S K; Haque, N; Barman, T K; Ahmed, S; Nasreen, S A; Hossain, M S; Ahmed, F; Biswas, P; Nahar, F; Begum, H; Islam, M S

    2016-07-01

    The aim of this study was to detect antimicrobial susceptibilities and the presence of drug resistance genes of MRSA from tertiary care hospitals. This study was carried out in the Department of Microbiology, Mymensingh Medical College during the period from Jan, 2015 to Dec, 2015. Clinical samples, including wound swab, pus, exudates from diabetic ulcer and burn ulcer, aural swab, blood and urine were collected. Standard microbiological procedure & biochemical tests were carried out to detect S. aureus. Oxacillin disk diffusion test was done by Kirby-Bauer disk diffusion method. Total 69 isolates of S. aureus were selected for the study. The isolates were collected from three different tertiary care hospitals, of which 33, 27 and 9 were from Mymensingh Medical College Hospital (MMCH), BIRDEM hospital and Sir Salimullah Medical College Hospital (SSMCH) respectively. Among the 69 isolates, 17(24.6%) and 52(75.3%) were distinguished as MRSA and MSSA respectively by ODDM (Oxacillin disk diffusion method). In contrast, detection of presence and absence of mecA gene by PCR identified 20 (28.9%) and 49 (71.01%) isolates as MRSA and MSSA respectively. All of the S. aureus (MRSA and MSSA) isolates were sensitive to vancomycin and gentamicin. All MRSA isolates (100%) showed resistance to Penicillin and Oxacillin. Among the MRSA isolates about 88.2% were resistance to Ceftazidime, 64.7% were resistance to Erythromycin and Ciprofloxacin, 11.7% were resistance to Tetracycline. Among the MSSA isolates about 94.2% were resistance to Penicillin and 9.6% resistance to Ciprofloxacin. The MSSA were less resistance for non-beta lactam drugs than MRSA. Regarding drug resistance genes, the blaZ genes were present in 47 out of 49(95.8%) MSSA and in 18 out of 18 (100%) MRSA. The erythromycin resistance gene ermB was found in 8.69% isolates, of which highest 20% in MRSA and 4.08% in MSSA. The ermA was not found in any isolates. Among tetracycline resistance genes, tetK were detected in 10

  3. MHD Generating system

    DOEpatents

    Petrick, Michael; Pierson, Edward S.; Schreiner, Felix

    1980-01-01

    According to the present invention, coal combustion gas is the primary working fluid and copper or a copper alloy is the electrodynamic fluid in the MHD generator, thereby eliminating the heat exchangers between the combustor and the liquid-metal MHD working fluids, allowing the use of a conventional coalfired steam bottoming plant, and making the plant simpler, more efficient and cheaper. In operation, the gas and liquid are combined in a mixer and the resulting two-phase mixture enters the MHD generator. The MHD generator acts as a turbine and electric generator in one unit wherein the gas expands, drives the liquid across the magnetic field and thus generates electrical power. The gas and liquid are separated, and the available energy in the gas is recovered before the gas is exhausted to the atmosphere. Where the combustion gas contains sulfur, oxygen is bubbled through a side loop to remove sulfur therefrom as a concentrated stream of sulfur dioxide. The combustor is operated substoichiometrically to control the oxide level in the copper.

  4. Disk MHD generator study

    NASA Technical Reports Server (NTRS)

    Retallick, F. D.

    1980-01-01

    Directly-fired, separately-fired, and oxygen-augmented MHD power plants incorporating a disk geometry for the MHD generator were studied. The base parameters defined for four near-optimum-performance MHD steam power systems of various types are presented. The finally selected systems consisted of (1) two directly fired cases, one at 1920 K (2996F) preheat and the other at 1650 K (2500 F) preheat, (2) a separately-fired case where the air is preheated to the same level as the higher temperature directly-fired cases, and (3) an oxygen augmented case with the same generator inlet temperature of 2839 (4650F) as the high temperature directly-fired and separately-fired cases. Supersonic Mach numbers at the generator inlet, gas inlet swirl, and constant Hall field operation were specified based on disk generator optimization. System pressures were based on optimization of MHD net power. Supercritical reheat stream plants were used in all cases. Open and closed cycle component costs are summarized and compared.

  5. Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.

    PubMed

    Hong, Eun-Gyoung; Jung, Dae Young; Ko, Hwi Jin; Zhang, Zhiyou; Ma, Zhexi; Jun, John Y; Kim, Jae Hyeong; Sumner, Andrew D; Vary, Thomas C; Gardner, Thomas W; Bronson, Sarah K; Kim, Jason K

    2007-12-01

    Although insulin resistance has been traditionally associated with type 2 diabetes, recent evidence in humans and animal models indicates that insulin resistance may also develop in type 1 diabetes. A point mutation of insulin 2 gene in Ins2(Akita) mice leads to pancreatic beta-cell apoptosis and hyperglycemia, and these mice are commonly used to investigate type 1 diabetes and complications. Since insulin resistance plays an important role in diabetic complications, we performed hyperinsulinemic-euglycemic clamps in awake Ins2(Akita) and wild-type mice to measure insulin action and glucose metabolism in vivo. Nonobese Ins2(Akita) mice developed insulin resistance, as indicated by an approximately 80% reduction in glucose infusion rate during clamps. Insulin resistance was due to approximately 50% decreases in glucose uptake in skeletal muscle and brown adipose tissue as well as hepatic insulin action. Skeletal muscle insulin resistance was associated with a 40% reduction in total GLUT4 and a threefold increase in PKCepsilon levels in Ins2(Akita) mice. Chronic phloridzin treatment lowered systemic glucose levels and normalized muscle insulin action, GLUT4 and PKCepsilon levels in Ins2(Akita) mice, indicating that hyperglycemia plays a role in insulin resistance. Echocardiography showed significant cardiac remodeling with ventricular hypertrophy that was ameliorated following chronic phloridzin treatment in Ins2(Akita) mice. Overall, we report for the first time that nonobese, insulin-deficient Ins2(Akita) mice develop type 2 diabetes phenotypes including peripheral and hepatic insulin resistance and cardiac remodeling. Our findings provide important insights into the pathogenesis of metabolic abnormalities and complications affecting type 1 diabetes and lean type 2 diabetes subjects. PMID:17911348

  6. Including dietary fiber and resistant starch to increase satiety and reduce aggression in gestating sows

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The swine industry is under a great deal of pressure to return sows to group housing. However, aggression during mixing of pregnant sows impacts sow welfare and productivity. The aim of this study was to increase satiety and reduce aggression by including dietary fiber and fermentable carbohydrate. ...

  7. Multifocal outbreaks of metallo-beta-lactamase-producing Pseudomonas aeruginosa resistant to broad-spectrum beta-lactams, including carbapenems.

    PubMed Central

    Senda, K; Arakawa, Y; Nakashima, K; Ito, H; Ichiyama, S; Shimokata, K; Kato, N; Ohta, M

    1996-01-01

    A total of 3,700 Pseudomonas aeruginosa isolates were collected from 17 general hospitals in Japan from 1992 to 1994. Of these isolates, 132 carbapenem-resistant strains were subjected to DNA hybridization analysis with the metallo-beta-lactamase gene (blaIMP)-specific probe. Fifteen strains carrying the metallo-beta-lactamase gene were identified in five hospitals in different geographical areas. Three strains of P. aeruginosa demonstrated high-level imipenem resistance (MIC, > or = 128 micrograms/ml), two strains exhibited low-level imipenem resistance (MIC, < or = 4 micrograms/ml), and the rest of the strains were in between. These results revealed that the acquisition of a metallo-beta-lactamase gene alone does not necessarily confer elevated resistance to carbapenems. In several strains, the metallo-beta-lactamase gene was carried by large plasmids, and carbapenem resistance was transferred from P. aeruginosa to Escherichia coli by electroporation in association with the acquisition of the large plasmid. Southern hybridization analysis and genomic DNA fingerprinting profiles revealed different genetic backgrounds for these 15 isolates, although considerable similarity was observed for the strains isolated from the same hospital. These findings suggest that the metallo-beta-lactamase-producing P. aeruginosa strains are not confined to a unique clonal lineage but proliferated multifocally by plasmid-mediated dissemination of the metallo-beta-lactamase gene in strains of different genetic backgrounds. Thus, further proliferation of metallo-beta-lactamase-producing strains with resistance to various beta-lactams may well be inevitable in the future, which emphasizes the need for early recognition of metallo-beta-lactamase-producing strains, rigorous infection control, and restricted clinical use of broad-spectrum beta-lactams including carbapenems. PMID:8834878

  8. Brownian dynamics simulations of a flexible polymer chain which includes continuous resistance and multibody hydrodynamic interactions

    NASA Astrophysics Data System (ADS)

    Butler, Jason E.; Shaqfeh, Eric S. G.

    2005-01-01

    Using methods adapted from the simulation of suspension dynamics, we have developed a Brownian dynamics algorithm with multibody hydrodynamic interactions for simulating the dynamics of polymer molecules. The polymer molecule is modeled as a chain composed of a series of inextensible, rigid rods with constraints at each joint to ensure continuity of the chain. The linear and rotational velocities of each segment of the polymer chain are described by the slender-body theory of Batchelor [J. Fluid Mech. 44, 419 (1970)]. To include hydrodynamic interactions between the segments of the chain, the line distribution of forces on each segment is approximated by making a Legendre polynomial expansion of the disturbance velocity on the segment, where the first two terms of the expansion are retained in the calculation. Thus, the resulting linear force distribution is specified by a center of mass force, couple, and stresslet on each segment. This method for calculating the hydrodynamic interactions has been successfully used to simulate the dynamics of noncolloidal suspensions of rigid fibers [O. G. Harlen, R. R. Sundararajakumar, and D. L. Koch, J. Fluid Mech. 388, 355 (1999); J. E. Butler and E. S. G. Shaqfeh, J. Fluid Mech. 468, 204 (2002)]. The longest relaxation time and center of mass diffusivity are among the quantities calculated with the simulation technique. Comparisons are made for different levels of approximation of the hydrodynamic interactions, including multibody interactions, two-body interactions, and the "freely draining" case with no interactions. For the short polymer chains studied in this paper, the results indicate a difference in the apparent scaling of diffusivity with polymer length for the multibody versus two-body level of approximation for the hydrodynamic interactions.

  9. Numerical analysis of real gas MHD flow on two-dimensional self-field MPD thrusters

    NASA Astrophysics Data System (ADS)

    Xisto, Carlos M.; Páscoa, José C.; Oliveira, Paulo J.

    2015-07-01

    A self-field magnetoplasmadynamic (MPD) thruster is a low-thrust electric propulsion space-system that enables the usage of magnetohydrodynamic (MHD) principles for accelerating a plasma flow towards high speed exhaust velocities. It can produce an high specific impulse, making it suitable for long duration interplanetary space missions. In this paper numerical results obtained with a new code, which is being developed at C-MAST (Centre for Mechanical and Aerospace Technologies), for a two-dimensional self-field MPD thruster are presented. The numerical model is based on the macroscopic MHD equations for compressible and electrically resistive flow and is able to predict the two most important thrust mechanisms that are associated with this kind of propulsion system, namely the thermal thrust and the electromagnetic thrust. Moreover, due to the range of very high temperatures that could occur during the operation of the MPD, it also includes a real gas model for argon.

  10. Neoclassical viscosity effects on resistive magnetohydrodynamic modes in toroidal geometry

    SciTech Connect

    Yang, J.G.; Oh, Y.H.; Choi, D.I. ); Kim, J.Y.; Horton, W. )

    1992-03-01

    The flux-surface-averaged linearized resistive magnetohydrodynamic (MHD) boundary-layer equations including the compressibility, diamagnetic drift, and neoclassical viscosity terms are derived in toroidal geometry. These equations describe the resistive layer dynamics of resistive MHD modes over the collisionality regime between the banana plateau and the Pfirsch--Schlueter. From the resulting equations, the effects of neoclassical viscosity on the stability of the tearing and resistive ballooning modes are investigated numerically. Also, a study is given for the problem of how the neoclassical resistive MHD mode is generated as the collisionality is reduced. It is shown that the neoclassical viscosity terms give a significant destabilizing effect for the tearing and resistive ballooning modes. This destabilization comes mainly from the reduction of the stabilizing effect of the parallel ion sound compression by the ion neoclassical viscosity. In the banana-plateau collisionality limit, where the compressibility is negligible, the dispersion relations of the tearing and resistive ballooning modes reduce to the same form, with the threshold value of the driving force given by {Delta}{sub {ital c}}=0. On the other hand, with the finite neoclassical effect it is found that the neoclassical resistive MHD instability is generated in agreement with previous results. Furthermore, it is shown that this later instability can be generated in a wide range of the collisionality including near the Pfirsch--Schlueter regime as well as the banana-plateau regime, suggesting that this mode is a probable cause of anomalous transport.

  11. Dry heat or gaseous chemical resistance of Bacillus subtilis var. niger spores included within water-soluble crystals.

    PubMed

    Mullican, C L; Hoffman, R K

    1968-08-01

    Inclusion of spores of Bacillus subtilis var. niger in water-soluble crystals increased the resistance of the spores to dry heat and to a gaseous mixture of methyl bromide and ethylene oxide. Resistance of spores in glycine crystals to dry heat at 125 C was increased 5 to 24 times compared to unprotected spores. There appeared to be a positive correlation between the size of the crystal and the degree of resistance. The resistance to dry heat of spores included in sodium chloride crystals was about six times greater than unprotected spores. A gaseous mixture of methyl bromide (964 mg/liter) and ethylene oxide (642 mg/liter) at 37% relative humidity was ineffective in sterilizing spores enclosed within these water-soluble crystals, as was ethylene oxide alone. However, if the relative humidity was sufficiently high to dissolve the crystals during exposure to the vapor, viable-spore counts were drastically reduced or were negative. The surfaces of crystals grossly contaminated with dry spores were sterilized by exposure to gaseous ethylene oxide. Sterilization of heat-labile or moisture-labile materials with a critical requirement for sterility, as in planetary probes or drugs, may be complicated by the presence of spores in naturally occurring water-soluble crystals. This phenomenon is similar to the protection afforded spores entrapped in solid plastics. PMID:4970891

  12. Dry Heat or Gaseous Chemical Resistance of Bacillus subtilis var. niger Spores Included Within Water-soluble Crystals

    PubMed Central

    Mullican, Charles L.; Hoffman, Robert K.

    1968-01-01

    Inclusion of spores of Bacillus subtilis var. niger in water-soluble crystals increased the resistance of the spores to dry heat and to a gaseous mixture of methyl bromide and ethylene oxide. Resistance of spores in glycine crystals to dry heat at 125 C was increased 5 to 24 times compared to unprotected spores. There appeared to be a positive correlation between the size of the crystal and the degree of resistance. The resistance to dry heat of spores included in sodium chloride crystals was about six times greater than unprotected spores. A gaseous mixture of methyl bromide (964 mg/liter) and ethylene oxide (642 mg/liter) at 37% relative humidity was ineffective in sterilizing spores enclosed within these water-soluble crystals, as was ethylene oxide alone. However, if the relative humidity was sufficiently high to dissolve the crystals during exposure to the vapor, viable-spore counts were drastically reduced or were negative. The surfaces of crystals grossly contaminated with dry spores were sterilized by exposure to gaseous ethylene oxide. Sterilization of heat-labile or moisture-labile materials with a critical requirement for sterility, as in planetary probes or drugs, may be complicated by the presence of spores in naturally occurring water-soluble crystals. This phenomenon is similar to the protection afforded spores entrapped in solid plastics. PMID:4970891

  13. An Antimicrobial Metabolite from Bacillus sp.: Significant Activity Against Pathogenic Bacteria Including Multidrug-Resistant Clinical Strains

    PubMed Central

    Chalasani, Ajay G.; Dhanarajan, Gunaseelan; Nema, Sushma; Sen, Ramkrishna; Roy, Utpal

    2015-01-01

    In this study, the cell free modified tryptone soya broth (pH 7.4 ± 0.2) of Bacillus subtilis URID 12.1 showed significant antimicrobial activity against multidrug-resistant strains of Staphylococcus aureus, S. epidermidis, Streptococcus pyogenes and Enterococcus faecalis. The partially purified antimicrobial molecule was found to be resistant to extremes of pH and temperatures and also to higher concentrations of trypsin and proteinase K. The antimicrobial molecule was purified by a three-step method that included reversed-phase high performance liquid chromatography (RP-HPLC). The minimum inhibitory concentration (MIC) values were determined for 14 species of bacteria using a microbroth dilution technique. The HPLC-purified fraction showed the MICs ranging from 0.5 to 16 μg/ml for methicillin and vancomycin-resistant Staphylococcus aureus (MVRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) strains. The molecular mass of the antimicrobial compound was determined to be 842.37 Da. The same antimicrobial fraction showed negligible haemolytic activity against human red blood cells even at a concentration as high as 100 μg/ml. Because of its significant antimicrobial activity at low MIC values coupled with its non-haemolytic property, it may prove to be a novel antimicrobial lead molecule. PMID:26696963

  14. Fully implicit adaptive mesh refinement algorithm for reduced MHD

    NASA Astrophysics Data System (ADS)

    Philip, Bobby; Pernice, Michael; Chacon, Luis

    2006-10-01

    In the macroscopic simulation of plasmas, the numerical modeler is faced with the challenge of dealing with multiple time and length scales. Traditional approaches based on explicit time integration techniques and fixed meshes are not suitable for this challenge, as such approaches prevent the modeler from using realistic plasma parameters to keep the computation feasible. We propose here a novel approach, based on implicit methods and structured adaptive mesh refinement (SAMR). Our emphasis is on both accuracy and scalability with the number of degrees of freedom. As a proof-of-principle, we focus on the reduced resistive MHD model as a basic MHD model paradigm, which is truly multiscale. The approach taken here is to adapt mature physics-based technology to AMR grids, and employ AMR-aware multilevel techniques (such as fast adaptive composite grid --FAC-- algorithms) for scalability. We demonstrate that the concept is indeed feasible, featuring near-optimal scalability under grid refinement. Results of fully-implicit, dynamically-adaptive AMR simulations in challenging dissipation regimes will be presented on a variety of problems that benefit from this capability, including tearing modes, the island coalescence instability, and the tilt mode instability. L. Chac'on et al., J. Comput. Phys. 178 (1), 15- 36 (2002) B. Philip, M. Pernice, and L. Chac'on, Lecture Notes in Computational Science and Engineering, accepted (2006)

  15. MHD Simulations of Plasma Dynamics with Non-Axisymmetric Boundaries

    NASA Astrophysics Data System (ADS)

    Hansen, Chris; Levesque, Jeffrey; Morgan, Kyle; Jarboe, Thomas

    2015-11-01

    The arbitrary geometry, 3D extended MHD code PSI-TET is applied to linear and non-linear simulations of MCF plasmas with non-axisymmetric boundaries. Progress and results from simulations on two experiments will be presented: 1) Detailed validation studies of the HIT-SI experiment with self-consistent modeling of plasma dynamics in the helicity injectors. Results will be compared to experimental data and NIMROD simulations that model the effect of the helicity injectors through boundary conditions on an axisymmetric domain. 2) Linear studies of HBT-EP with different wall configurations focusing on toroidal asymmetries in the adjustable conducting wall. HBT-EP studies the effect of active/passive stabilization with an adjustable ferritic wall. Results from linear verification and benchmark studies of ideal mode growth with and without toroidal asymmetries will be presented and compared to DCON predictions. Simulations of detailed experimental geometries are enabled by use of the PSI-TET code, which employs a high order finite element method on unstructured tetrahedral grids that are generated directly from CAD models. Further development of PSI-TET will also be presented including work to support resistive wall regions within extended MHD simulations. Work supported by DoE.

  16. Cosmological AMR MHD with Enzo

    SciTech Connect

    Xu, Hao; Li, Hui; Li, Shengtai

    2009-01-01

    In this work, we present EnzoMHD, the extension of the cosmological code Enzoto include magnetic fields. We use the hyperbolic solver of Li et al. (2008) for the computation of interface fluxes. We use constrained transport methods of Balsara & Spicer (1999) and Gardiner & Stone (2005) to advance the induction equation, the reconstruction technique of Balsara (2001) to extend the Adaptive Mesh Refinement of Berger & Colella (1989) already used in Enzo, though formulated in a slightly different way for ease of implementation. This combination of methods preserves the divergence of the magnetic field to machine precision. We use operator splitting to include gravity and cosmological expansion. We then present a series of cosmological and non cosmologjcal tests problems to demonstrate the quality of solution resulting from this combination of solvers.

  17. MHD Integrated Topping Cycle Project

    SciTech Connect

    Not Available

    1992-07-01

    This seventeenth quarterly technical progress report of the MHD Integrated Topping Cycle Project presents the accomplishments during the period August 1, 1991 to October 31, 1991. Manufacturing of the prototypical combustor pressure shell has been completed including leak, proof, and assembly fit checking. Manufacturing of forty-five cooling panels was also completed including leak, proof, and flow testing. All precombustor internal components (combustion can baffle and swirl box) were received and checked, and integration of the components was initiated. A decision was made regarding the primary and backup designs for the 1A4 channel. The assembly of the channel related prototypical hardware continued. The cathode wall electrical wiring is now complete. The mechanical design of the diffuser has been completed.

  18. Toroidal Theory of MHD Instabilities

    SciTech Connect

    Goedbloed, J.P.

    2004-03-15

    We continue with the adventures of the Alfven wave and its two magnetosonic companions as they travel in the curved space of magnetic surfaces and field lines (Sec. 2), find themselves trapped in singularities of an unprecedented richness (Sec. 3), decide to get themselves better maps of the landscape to do the required twisting while some of their youthful energy is leaking away (Sec. 4), cause trouble at the edge of a powerful empire (Sec. 5), and finally see the light in a distant future (Sec. 6). Needed on the trip are the evolution equations of both ideal and resistive MHD 'derived' in reference [1], the solutions to the toroidal equilibrium equations discussed in reference [2], the general background on spectral theory of inhomogeneous plasmas presented in reference [3], which is extended in the two directions of toroidal geometry and resistivity in this lecture [4]. This leads to such intricate dynamics that numerical techniques are virtually the only way to proceed. This aspect is further elaborated in reference [5] on numerical techniques.

  19. Fully Parallel MHD Stability Analysis Tool

    NASA Astrophysics Data System (ADS)

    Svidzinski, Vladimir; Galkin, Sergei; Kim, Jin-Soo; Liu, Yueqiang

    2014-10-01

    Progress on full parallelization of the plasma stability code MARS will be reported. MARS calculates eigenmodes in 2D axisymmetric toroidal equilibria in MHD-kinetic plasma models. It is a powerful tool for studying MHD and MHD-kinetic instabilities and it is widely used by fusion community. Parallel version of MARS is intended for simulations on local parallel clusters. It will be an efficient tool for simulation of MHD instabilities with low, intermediate and high toroidal mode numbers within both fluid and kinetic plasma models, already implemented in MARS. Parallelization of the code includes parallelization of the construction of the matrix for the eigenvalue problem and parallelization of the inverse iterations algorithm, implemented in MARS for the solution of the formulated eigenvalue problem. Construction of the matrix is parallelized by distributing the load among processors assigned to different magnetic surfaces. Parallelization of the solution of the eigenvalue problem is made by repeating steps of the present MARS algorithm using parallel libraries and procedures. Initial results of the code parallelization will be reported. Work is supported by the U.S. DOE SBIR program.

  20. Fully Parallel MHD Stability Analysis Tool

    NASA Astrophysics Data System (ADS)

    Svidzinski, Vladimir; Galkin, Sergei; Kim, Jin-Soo; Liu, Yueqiang

    2013-10-01

    Progress on full parallelization of the plasma stability code MARS will be reported. MARS calculates eigenmodes in 2D axisymmetric toroidal equilibria in MHD-kinetic plasma models. It is a powerful tool for studying MHD and MHD-kinetic instabilities and it is widely used by fusion community. Parallel version of MARS is intended for simulations on local parallel clusters. It will be an efficient tool for simulation of MHD instabilities with low, intermediate and high toroidal mode numbers within both fluid and kinetic plasma models, already implemented in MARS. Parallelization of the code includes parallelization of the construction of the matrix for the eigenvalue problem and parallelization of the inverse iterations algorithm, implemented in MARS for the solution of the formulated eigenvalue problem. Construction of the matrix is parallelized by distributing the load among processors assigned to different magnetic surfaces. Parallelization of the solution of the eigenvalue problem is made by repeating steps of the present MARS algorithm using parallel libraries and procedures. Preliminary results of the code parallelization will be reported. Work is supported by the U.S. DOE SBIR program.

  1. Fully Parallel MHD Stability Analysis Tool

    NASA Astrophysics Data System (ADS)

    Svidzinski, Vladimir; Galkin, Sergei; Kim, Jin-Soo; Liu, Yueqiang

    2015-11-01

    Progress on full parallelization of the plasma stability code MARS will be reported. MARS calculates eigenmodes in 2D axisymmetric toroidal equilibria in MHD-kinetic plasma models. It is a powerful tool for studying MHD and MHD-kinetic instabilities and it is widely used by fusion community. Parallel version of MARS is intended for simulations on local parallel clusters. It will be an efficient tool for simulation of MHD instabilities with low, intermediate and high toroidal mode numbers within both fluid and kinetic plasma models, already implemented in MARS. Parallelization of the code includes parallelization of the construction of the matrix for the eigenvalue problem and parallelization of the inverse iterations algorithm, implemented in MARS for the solution of the formulated eigenvalue problem. Construction of the matrix is parallelized by distributing the load among processors assigned to different magnetic surfaces. Parallelization of the solution of the eigenvalue problem is made by repeating steps of the present MARS algorithm using parallel libraries and procedures. Results of MARS parallelization and of the development of a new fix boundary equilibrium code adapted for MARS input will be reported. Work is supported by the U.S. DOE SBIR program.

  2. MHD Wave Modes Resolved in Fine-Scale Chromospheric Magnetic Structures

    NASA Astrophysics Data System (ADS)

    Verth, G.; Jess, D. B.

    2016-02-01

    Due to its complex and dynamic fine-scale structure, the chromosphere is a particularly challenging region of the Sun's atmosphere to understand. It is now widely accepted that to model chromospheric dynamics, even on a magnetohydrodynamic (MHD) scale, while also calculating spectral line emission, one must realistically include the effects of partial ionization and radiative transfer in a multi-fluid plasma under non-LTE conditions. Accurate quantification of MHD wave energetics must be founded on a precise identification of the actual wave mode being observed. This chapter focuses on MHD kink-mode identification, MHD sausage mode identification, and MHD torsional Alfvén wave identification. It then reviews progress in determining more accurate energy flux estimations of specific MHD wave modes observed in the chromosphere. The chapter finally examines how the discovery of these MHD wave modes has helped us advance the field of chromospheric magnetoseismology.

  3. Hilbert-Huang Transform in MHD Plasma Diagnostics

    SciTech Connect

    Kakurin, A.M.; Orlovsky, I.I.

    2005-12-15

    A new method for processing experimental data from MHD diagnostics is discussed that provides a more detailed study of the dynamics of large-scale MHD instabilities. The method is based on the Hilbert-Huang transform method and includes an empirical mode decomposition algorithm, which is used to decompose the experimental MHD diagnostic signals into a set of frequency- and amplitude-modulated harmonics in order to construct the time evolutions of the amplitudes and frequencies of these harmonics with the help of the Hilbert transform. The method can also be applied to analyze data from other diagnostics that measure unsteady oscillating signals.

  4. Broken Ergodicity in MHD Turbulence in a Spherical Domain

    NASA Technical Reports Server (NTRS)

    Shebalin, John V.; wang, Yifan

    2011-01-01

    Broken ergodicity (BE) occurs in Fourier method numerical simulations of ideal, homogeneous, incompressible magnetohydrodynamic (MHD) turbulence. Although naive statistical theory predicts that Fourier coefficients of fluid velocity and magnetic field are zero-mean random variables, numerical simulations clearly show that low-wave-number coefficients have non-zero mean values that can be very large compared to the associated standard deviation. In other words, large-scale coherent structure (i.e., broken ergodicity) in homogeneous MHD turbulence can spontaneously grow out of random initial conditions. Eigenanalysis of the modal covariance matrices in the probability density functions of ideal statistical theory leads to a theoretical explanation of observed BE in homogeneous MHD turbulence. Since dissipation is minimal at the largest scales, BE is also relevant for resistive magnetofluids, as evidenced in numerical simulations. Here, we move beyond model magnetofluids confined by periodic boxes to examine BE in rotating magnetofluids in spherical domains using spherical harmonic expansions along with suitable boundary conditions. We present theoretical results for 3-D and 2-D spherical models and also present computational results from dynamical simulations of 2-D MHD turbulence on a rotating spherical surface. MHD turbulence on a 2-D sphere is affected by Coriolus forces, while MHD turbulence on a 2-D plane is not, so that 2-D spherical models are a useful (and simpler) intermediate stage on the path to understanding the much more complex 3-D spherical case.

  5. Kinetic MHD simulation of large 'circ; tearing mode

    NASA Astrophysics Data System (ADS)

    Cheng, Jianhua; Chen, Yang; Parker, Scott; Uzdensky, Dmitri

    2012-03-01

    We have developed a second-order accurate semi-implicit δ method for kinetic MHD simulation with Lorentz force ions and fluid electrons. The model has been used to study the resistive tearing mode instability, which involves multiple spatial scales. In small 'circ; cases, the linear growth rate and eigenmode structure are consistent with resistive MHD analysis. The Rutherford stage and saturation are demonstrated, but the simulation exhibits different saturation island widths compared with previous MHD simulations. In large 'circ; cases, nonlinear simulations show multiple islands forming, followed by the islands coalescing at later times. The competition between these two processes strongly influences the reconnection rates and eventually leads to a steady state reconnection. We will present various parameter studies and show that our hybrid results agree with fluid analysis in certain limits (e.g., relatively large resisitivities).

  6. Commercialization of MHD power technology

    SciTech Connect

    Aleman, D.J.; Jensen, A.D.; Probert, P.B.

    1984-08-01

    This paper presents an approach to the commercialization of Magnetohydrodynamics (MHD) technology from the perspective of an equipment manufacturer. It discusses and recommends actions to be taken in solving technical problems and mitigating risk for the first commercial MHD power plant.

  7. American Bullfrogs (Lithobates catesbeianus) Resist Infection by Multiple Isolates of Batrachochytrium dendrobatidis, Including One Implicated in Wild Mass Mortality.

    PubMed

    Eskew, Evan A; Worth, S Joy; Foley, Janet E; Todd, Brian D

    2015-09-01

    The emerging amphibian disease chytridiomycosis varies in severity depending on host species. Within species, disease susceptibility can also be influenced by pathogen variation and environmental factors. Here, we report on experimental exposures of American bullfrogs (Lithobates catesbeianus) to three different isolates of Batrachochytrium dendrobatidis (Bd), including one implicated in causing mass mortality of wild American bullfrogs. Exposed frogs showed low infection prevalence, relatively low infection load, and lack of clinical disease. Our results suggest that environmental cofactors are likely important contributors to Bd-associated American bullfrog mortality and that this species both resists and tolerates Bd infection. PMID:26065669

  8. Intensive lifestyle intervention including high-intensity interval training program improves insulin resistance and fasting plasma glucose in obese patients☆

    PubMed Central

    Marquis-Gravel, Guillaume; Hayami, Douglas; Juneau, Martin; Nigam, Anil; Guilbeault, Valérie; Latour, Élise; Gayda, Mathieu

    2015-01-01

    Objectives To analyze the effects of a long-term intensive lifestyle intervention including high-intensity interval training (HIIT) and Mediterranean diet (MedD) counseling on glycemic control parameters, insulin resistance and β-cell function in obese subjects. Methods The glycemic control parameters (fasting plasma glucose, glycated hemoglobin), insulin resistance, and β-cell function of 72 obese subjects (54 women; mean age = 53 ± 9 years) were assessed at baseline and upon completion of a 9-month intensive lifestyle intervention program conducted at the cardiovascular prevention and rehabilitation center of the Montreal Heart Institute, from 2009 to 2012. The program included 2–3 weekly supervised exercise training sessions (HIIT and resistance exercise), combined to MedD counseling. Results Fasting plasma glucose (FPG) (mmol/L) (before: 5.5 ± 0.9; after: 5.2 ± 0.6; P < 0.0001), fasting insulin (pmol/L) (before: 98 ± 57; after: 82 ± 43; P = 0.003), and insulin resistance, as assessed by the HOMA-IR score (before: 3.6 ± 2.5; after: 2.8 ± 1.6; P = 0.0008) significantly improved, but not HbA1c (%) (before: 5.72 ± 0.55; after: 5.69 ± 0.39; P = 0.448), nor β-cell function (HOMA-β, %) (before: 149 ± 78; after: 144 ± 75; P = 0.58). Conclusion Following a 9-month intensive lifestyle intervention combining HIIT and MedD counseling, obese subjects experienced significant improvements of FPG and insulin resistance. This is the first study to expose the effects of a long-term program combining HIIT and MedD on glycemic control parameters among obese subjects. PMID:26844086

  9. Fully implicit adaptive mesh refinement MHD algorithm

    NASA Astrophysics Data System (ADS)

    Philip, Bobby

    2005-10-01

    In the macroscopic simulation of plasmas, the numerical modeler is faced with the challenge of dealing with multiple time and length scales. The former results in stiffness due to the presence of very fast waves. The latter requires one to resolve the localized features that the system develops. Traditional approaches based on explicit time integration techniques and fixed meshes are not suitable for this challenge, as such approaches prevent the modeler from using realistic plasma parameters to keep the computation feasible. We propose here a novel approach, based on implicit methods and structured adaptive mesh refinement (SAMR). Our emphasis is on both accuracy and scalability with the number of degrees of freedom. To our knowledge, a scalable, fully implicit AMR algorithm has not been accomplished before for MHD. As a proof-of-principle, we focus on the reduced resistive MHD model as a basic MHD model paradigm, which is truly multiscale. The approach taken here is to adapt mature physics-based technologyootnotetextL. Chac'on et al., J. Comput. Phys. 178 (1), 15- 36 (2002) to AMR grids, and employ AMR-aware multilevel techniques (such as fast adaptive composite --FAC-- algorithms) for scalability. We will demonstrate that the concept is indeed feasible, featuring optimal scalability under grid refinement. Results of fully-implicit, dynamically-adaptive AMR simulations will be presented on a variety of problems.

  10. Conceptual design of the MHD Engineering Test Facility

    NASA Technical Reports Server (NTRS)

    Bents, D. J.; Bercaw, R. W.; Burkhart, J. A.; Mroz, T. S.; Rigo, H. S.; Pearson, C. V.; Warinner, D. K.; Hatch, A. M.; Borden, M.; Giza, D. A.

    1981-01-01

    The reference conceptual design of the MHD engineering test facility, a prototype 200 MWe coal-fired electric generating plant designed to demonstrate the commerical feasibility of open cycle MHD is summarized. Main elements of the design are identified and explained, and the rationale behind them is reviewed. Major systems and plant facilities are listed and discussed. Construction cost and schedule estimates are included and the engineering issues that should be reexamined are identified.

  11. MHD Integrated Topping Cycle Project

    SciTech Connect

    Not Available

    1992-02-01

    A summary of the work is excerpted here. Final design of an MHD channel for the ITC program POC test has been completed. The channel was designed to be capable of 1.5 MW {sub e} power output and a lifetime of 2000 hours. Emphasis was placed upon durability and reliability. Hence, specific measures were taken to design against channel damage due to electric faults. The life-limiting issues associated with electrochemical corrosion and erosion of gas-side surfaces were addressed by the use of various materials with proven wear characteristics in a coal-fired MHD channel environment. Pitting of prototypical sidewall coupons was observed in the CDIF workhorse testing. The most likely cause of the observed pitting, water leaks resulting from cooling water tube braze failures, has been remedied. New brazing procedures and isolation of the sidebar gas-side material from water contact will prevent sidebar pitting in the prototypical channel. Water-side corrosion tests reported in this quarterly report include the latest results of tungsten-copper elements at controlled pH, heat flux and voltage levels. In the combustion subsystem, efforts continued to focus on understanding and improving the current levels of slag recovery and seed utilization achieved by the combustor. Analytical support was also provided in the areas of slag rejection system operation, precombustor operation, and oil burner design modification. Channel data analysis activities continued in support of prototypical coupon testing at the CDIF. Analyses are presented on channel wall slagging behavior and sidewall voltage distributions.

  12. Energy storage and dissipation in the magnetotail during substorms 2. MHD simulations

    NASA Astrophysics Data System (ADS)

    Steinolfson, R. S.; Winglee, R. M.

    1993-05-01

    The effects of temporal and spatial variations in the plasma resistivity on the evolution of the magnetosphere during substorms are examined with numerical solutions of the two-dimensional magnetohydrodynamic (MHD) equations. The global MHD simulations self-consistently consider the interaction of the solar wind with the dayside magnetosphere as well as the evolution of the tail region. These solutions are used to study how various solar wind states generate conditions in the tail, such as pressure gradients and cross-tail currents, that have the potential of leading to a substorm. Although the MHD formalism does provide information on the large-scale evolution, the essential mechanism for substorm development may involve microscopic or particle processes not present in an MHD approach. As a result, this MHD study is carried out in association with particle simulations (Winglee and Steinolfson, this issue). Since one connection between the MHD and particle approaches is through the resistivity, the effects of various resistivity distributions on the global MHD configuration are examined. The resistivity distributions considered here are (1) a temporally constant and spatially uniform resistivity, (2) a resistivity proportional to the square of the local current density, and (3) a resistivity proportional to the square of the local magnetic field strength. The latter distribution is suggested by the above particle simulations and represents effects produced by the increased magnetization of particles and the differential motion between electrons and ions. For all three cases a plasmoid is formed and ejected tailward. However, when the resistivity depends on the field strength, considerably more energy is stored in the tail prior to plasmoid formation, and plasmoid formation is delayed relative to the results for the other two resistivity distributions. Furthermore, when the plasmoid is eventually ejected, it moves down the tail with a higher speed. The MHD results

  13. 3D MHD Simulations of Tokamak Disruptions

    NASA Astrophysics Data System (ADS)

    Woodruff, Simon; Stuber, James

    2014-10-01

    Two disruption scenarios are modeled numerically by use of the CORSICA 2D equilibrium and NIMROD 3D MHD codes. The work follows the simulations of pressure-driven modes in DIII-D and VDEs in ITER. The aim of the work is to provide starting points for simulation of tokamak disruption mitigation techniques currently in the CDR phase for ITER. Pressure-driven instability growth rates previously observed in simulations of DIIID are verified; Halo and Hiro currents produced during vertical displacements are observed in simulations of ITER with implementation of resistive walls in NIMROD. We discuss plans to exercise new code capabilities and validation.

  14. Laser-powered MHD generators for space application

    NASA Technical Reports Server (NTRS)

    Jalufka, N. W.

    1986-01-01

    Magnetohydrodynamic (MHD) energy conversion systems of the pulsed laser-supported detonation (LSD) wave, plasma MHD, and liquid-metal MHD (LMMHD) types are assessed for their potential as space-based laser-to-electrical power converters. These systems offer several advantages as energy converters relative to the present chemical, nuclear, and solar devices, including high conversion efficiency, simple design, high-temperature operation, high power density, and high reliability. Of these systems, the Brayton cycle liquid-metal MHD system appears to be the most attractive. The LMMHD technology base is well established for terrestrial applications, particularly with regard to the generator, mixer, and other system components. However, further research is required to extend this technology base to space applications and to establish the technology required to couple the laser energy into the system most efficiently. Continued research on each of the three system types is recommended.

  15. High-magnetic-field MHD-generator program

    NASA Astrophysics Data System (ADS)

    Nakamura, T.; Eustis, R. H.; Mitchner, M.; Self, S. A.; Koester, J. K.; Kruger, C. H.

    1981-07-01

    Progress in an experimental and theoretical program designed to investigate MHD channel phenomena which are important at high magnetic fields is described. The areas of research include nonuniformity effects, boundary layers, Hall field breakdown, the effects of electrode configuration and current concentrations, and studies of steady-state combustion disk and linear channels in an existing 6 Tesla magnet of small dimensions. In the study of the effects of nonuniformities, experiments were performed to test a multi-channel, fiber optics diagnostic system that yields time-resolved temperature profiles in an MHD chanel. For the study of magneto-acoustic fluctuation phenomena, a one dimensional model was developed to describe the performance of a non-ideal MHD generator with a generalized electrical configuration. A two dimensional MHD computer code was developed which predicts the dependence on electrode and insulator dimensions of the onset of interelectrode Hall field breakdown, as initiated either by breakdown in the insulator or in the plasma.

  16. MHD Technology Transfer, Integration and Review Committee

    SciTech Connect

    Not Available

    1992-01-01

    This fifth semi-annual status report of the MHD Technology Transfer, Integration, and Review Committee (TTIRC) summarizes activities of the TTIRC during the period April 1990 through September 1990. It includes summaries and minutes of committee meetings, progress summaries of ongoing Proof-of-Concept (POC) contracts, discussions pertaining to technical integration issues in the POC program, and planned activities for the next six months.

  17. Dispersive waves in a seeded MHD generator.

    NASA Technical Reports Server (NTRS)

    Harstad, K. G.

    1972-01-01

    The equations giving the response of a slightly ionized plasma with monatomic components to sinusoidal perturbations have been formulated. Included in the model equations were the electron Hall effect, electron thermal diffusion, radiation, and electron-atom rate processes. Plasma conditions were limited to those where viscous effects, the induced magnetic field, ion slip, and atom-atom inelastic processes can be neglected. Presented are results of numerical calculations for MHD generators with a working fluid of potassium seeded argon.

  18. The role of the electron convection term for the parallel electric field and electron acceleration in MHD simulations

    SciTech Connect

    Matsuda, K.; Terada, N.; Katoh, Y.; Misawa, H.

    2011-08-15

    There has been a great concern about the origin of the parallel electric field in the frame of fluid equations in the auroral acceleration region. This paper proposes a new method to simulate magnetohydrodynamic (MHD) equations that include the electron convection term and shows its efficiency with simulation results in one dimension. We apply a third-order semi-discrete central scheme to investigate the characteristics of the electron convection term including its nonlinearity. At a steady state discontinuity, the sum of the ion and electron convection terms balances with the ion pressure gradient. We find that the electron convection term works like the gradient of the negative pressure and reduces the ion sound speed or amplifies the sound mode when parallel current flows. The electron convection term enables us to describe a situation in which a parallel electric field and parallel electron acceleration coexist, which is impossible for ideal or resistive MHD.

  19. Thiamine induced resistance to Plasmopara viticola in grapevine and elicited host-defense responses, including HR like-cell death.

    PubMed

    Boubakri, Hatem; Wahab, Mohamed Ali; Chong, Julie; Bertsch, Christophe; Mliki, Ahmed; Soustre-Gacougnolle, Isabelle

    2012-08-01

    Recently, thiamine (VitaminB1) has been shown to induce resistance against Pseudomonas syringae in Arabidopsis plants through priming of defense responses. In this paper, we have demonstrated the efficiency of thiamine to induce resistance against downy mildew caused by the oomycete Plasmopara viticola in a susceptible Vitis vinifera cultivar "Chardonnay" under glasshouse controlled conditions by providing a dual mode of action involving direct antifungal activity and elicitation of host-defense responses. Thiamine-induced defense responses included the generation of hydrogen peroxide (H(2)O(2)) in both grapevine suspension cultured cells (SCC) and plant leaves, upregulation of an array of defense-related genes and the induction of other defense responses at subcellular level such as callose deposition in stomata cells, phenolic compounds accumulation and hypersensitive response (HR) like-cell death. Epifluorescence microscopy studies revealed dramatic changes in P. viticola individual developmental stages during its colonization of the intercellular space of the leaf mesophyll in thiamine-treated plants. Collectively, our report evidenced the efficiency of thiamine in the control of downy mildew in grapevine by direct and indirect effects, suggesting that thiamine could be an attractive alternative to chemical fungicides in disease management in vineyards. PMID:22698755

  20. Magnetohydrodynamic (MHD) nuclear weapons effects on submarine cable systems. Volume 1. Experiments and analysis. Final report

    SciTech Connect

    Not Available

    1987-06-01

    This report presents a study of the nuclear weapons magnetohydrodynamic (MHD) effects on submarine communications cables. The study consisted of the analysis and interpretation of currently available data on submarine cable systems TAT-4, TAT-6, and TAT-7. The primary result of the study is that decrease of the effective resistivity with frequency over the available experimental range, coupled with the model results, leads to quite small effective resistivities at the MHD characteristic frequencies, and hence small earth potential differences. Thus, it appears that submarine cable systems are less susceptible to an MHD threat than their land-based counter-parts.

  1. Adaptive Numerical Dissipation Control in High Order Schemes for Multi-D Non-Ideal MHD

    NASA Technical Reports Server (NTRS)

    Yee, H. C.; Sjoegreen, B.

    2005-01-01

    The required type and amount of numerical dissipation/filter to accurately resolve all relevant multiscales of complex MHD unsteady high-speed shock/shear/turbulence/combustion problems are not only physical problem dependent, but also vary from one flow region to another. In addition, proper and efficient control of the divergence of the magnetic field (Div(B)) numerical error for high order shock-capturing methods poses extra requirements for the considered type of CPU intensive computations. The goal is to extend our adaptive numerical dissipation control in high order filter schemes and our new divergence-free methods for ideal MHD to non-ideal MHD that include viscosity and resistivity. The key idea consists of automatic detection of different flow features as distinct sensors to signal the appropriate type and amount of numerical dissipation/filter where needed and leave the rest of the region free from numerical dissipation contamination. These scheme-independent detectors are capable of distinguishing shocks/shears, flame sheets, turbulent fluctuations and spurious high-frequency oscillations. The detection algorithm is based on an artificial compression method (ACM) (for shocks/shears), and redundant multiresolution wavelets (WAV) (for the above types of flow feature). These filters also provide a natural and efficient way for the minimization of Div(B) numerical error.

  2. A Mechanism for the Loading-Unloading Substorm Cycle Missing in MHD Global Magnetospheric Simulation Models

    NASA Technical Reports Server (NTRS)

    Klimas, A. J.; Uritsky, V.; Vassiliadis, D.; Baker, D. N.

    2005-01-01

    Loading and consequent unloading of magnetic flux is an essential element of the substorm cycle in Earth's magnetotail. We are unaware of an available global MHD magnetospheric simulation model that includes a loading- unloading cycle in its behavior. Given the central role that MHD models presently play in the development of our understanding of magnetospheric dynamics, and given the present plans for the central role that these models will play in ongoing space weather prediction programs, it is clear that this failure must be corrected. A 2-dimensional numerical driven current-sheet model has been developed that incorporates an idealized current- driven instability with a resistive MHD system. Under steady loading, the model exhibits a global loading- unloading cycle. The specific mechanism for producing the loading-unloading cycle will be discussed. It will be shown that scale-free avalanching of electromagnetic energy through the model, from loading to unloading, is carried by repetitive bursts of localized reconnection. Each burst leads, somewhat later, to a field configuration that is capable of exciting a reconnection burst again. This process repeats itself in an intermittent manner while the total field energy in the system falls. At the end of an unloading interval, the total field energy is reduced to well below that necessary to initiate the next unloading event and, thus, a loading-unloading cycle results. It will be shown that, in this model, it is the topology of bursty localized reconnection that is responsible for the appearance of the loading-unloading cycle.

  3. Production of MHD fluid

    DOEpatents

    Lacey, James J.; Kurtzrock, Roy C.; Bienstock, Daniel

    1976-08-24

    A hot gaseous fluid of low ash content, suitable for use in open-cycle MHD (magnetohydrodynamic) power generation, is produced by means of a three-stage process comprising (1) partial combustion of a fossil fuel to produce a hot gaseous product comprising CO.sub.2 CO, and H.sub.2 O, (2) reformation of the gaseous product from stage (1) by means of a fluidized char bed, whereby CO.sub.2 and H.sub.2 O are converted to CO and H.sub.2, and (3) combustion of CO and H.sub.2 from stage (2) to produce a low ash-content fluid (flue gas) comprising CO.sub.2 and H.sub.2 O and having a temperature of about 4000.degree. to 5000.degree.F.

  4. MHD channel performance for potential early commercial MHD power plants

    NASA Technical Reports Server (NTRS)

    Swallom, D. W.

    1981-01-01

    The commercial viability of full and part load early commercial MHD power plants is examined. The load conditions comprise a mass flow of 472 kg/sec in the channel, Rosebud coal, 34% by volume oxygen in the oxidizer preheated to 922 K, and a one percent by mass seeding with K. The full load condition is discussed in terms of a combined cycle plant with optimized electrical output by the MHD channel. Various electrical load parameters, pressure ratios, and magnetic field profiles are considered for a baseload MHD generator, with a finding that a decelerating flow rate yields slightly higher electrical output than a constant flow rate. Nominal and part load conditions are explored, with a reduced gas mass flow rate and an enriched oxygen content. An enthalpy extraction of 24.6% and an isentropic efficiency of 74.2% is predicted for nominal operation of a 526 MWe MHD generator, with higher efficiencies for part load operation.

  5. Activity of Eravacycline against Enterobacteriaceae and Acinetobacter baumannii, Including Multidrug-Resistant Isolates, from New York City

    PubMed Central

    Abdallah, Marie; Olafisoye, Olawole; Cortes, Christopher; Urban, Carl; Landman, David

    2014-01-01

    Eravacycline demonstrated in vitro activity against a contemporary collection of more than 4,000 Gram-negative pathogens from New York City hospitals, with MIC50/MIC90 values, respectively, for Escherichia coli of 0.12/0.5 μg/ml, Klebsiella pneumoniae of 0.25/1 μg/ml, Enterobacter aerogenes of 0.25/1 μg/ml, Enterobacter cloacae 0.5/1 μg/ml, and Acinetobacter baumannii of 0.5/1 μg/ml. Activity was retained against multidrug-resistant isolates, including those expressing KPC and OXA carbapenemases. For A. baumannii, eravacycline MICs correlated with increased expression of the adeB gene. PMID:25534744

  6. Magnetohydrodynamics (MHD) Engineering Test Facility (ETF) 200 MWe power plant Conceptual Design Engineering Report (CDER)

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The reference conceptual design of the magnetohydrodynamic (MHD) Engineering Test Facility (ETF), a prototype 200 MWe coal-fired electric generating plant designed to demonstrate the commercial feasibility of open cycle MHD, is summarized. Main elements of the design, systems, and plant facilities are illustrated. System design descriptions are included for closed cycle cooling water, industrial gas systems, fuel oil, boiler flue gas, coal management, seed management, slag management, plant industrial waste, fire service water, oxidant supply, MHD power ventilating

  7. Design of closed-cycle MHD generator with nonequilibrium ionization and system

    NASA Technical Reports Server (NTRS)

    Voshall, R. E.; Wright, R. J.; Liebermann, R. W.

    1977-01-01

    A method is developed to include the nonequilibrium ionization process in the MHD generator duct design equations, and these equations are coupled to the thermodynamic conditions of the closed cycle system. This is used to relate MHD generator size, configuration and gas conditions to the overall thermodynamic efficiency of the system. The system studied consists of an MHD loop (Ar + Cs or He + Cs) topping a steam bottoming plant.

  8. MHD technology in aluminum casting

    SciTech Connect

    Kalinichenko, I.

    1984-08-01

    The use of MHD technology in aluminum casting is discussed. Associates of the Latvian Academy of Sciences Institute of Physics developed magnetohydrodynamic units for the Siberian plant. A MHD unit made it possible to free five persons from heavy work at the plant. Labor productivity doubled in this section. With the aid of the magnetic field, the alloy silumin is obtained in only three hours. Specialists of the Irkutsk affiliate of the All-Union Scientific Research and Design Institute of the Aluminum, Magnesium and Electrode Industry are convinced that MHD technology has a bright future. However, this will necessitate the development of new MHD technology for different types of casting facilities, with their specific features taken into account.

  9. Propagation and Dissipation of MHD Waves in Coronal Holes

    NASA Astrophysics Data System (ADS)

    Dwivedi, B. N.

    2006-11-01

    bholadwivedi@gmail.com In view of the landmark result on the solar wind outflow, starting between 5 Mm and 20 Mm above the photosphere in magnetic funnels, we investigate the propagation and dissipation of MHD waves in coronal holes. We underline the importance of Alfvén wave dissipation in the magnetic funnels through the viscous and resistive plasma. Our results show that Alfvén waves are one of the primary energy sources in the innermost part of coronal holes where the solar wind outflow starts. We also consider compressive viscosity and thermal conductivity to study the propagation and dissipation of long period slow longitudinal MHD waves in polar coronal holes. We discuss their likely role in the line profile narrowing, and in the energy budget for coronal holes and the solar wind. We compare the contribution of longitudinal MHD waves with high frequency Alfvén waves.

  10. MHD Simulations of Thermal Plasma Jets in Coaxial Plasma Accelerators

    NASA Astrophysics Data System (ADS)

    Subramaniam, Vivek; Raja, Laxminarayan

    2015-09-01

    The development of a magneto-hydrodynamics (MHD) numerical tool to study high energy density thermal plasma in coaxial plasma accelerators is presented. The coaxial plasma accelerator is a device used simulate the conditions created at the confining wall of a thermonuclear fusion reactor during an edge localized mode (ELM) disruption event. This is achieved by creating magnetized thermal plasma in a coaxial volume which is then accelerated by the Lorentz force to form a high velocity plasma jet. The simulation tool developed solves the resistive MHD equation using a finite volume method (FVM) framework. The acceleration and subsequent demagnetization of the plasma as it travels down the length of the accelerator is simulated and shows good agreement with experiments. Additionally, a model to study the thermalization of the plasma at the inlet is being developed in order to give self-consistent initial conditions to the MHD solver.

  11. Perturbed Stability Analysis of External Ideal MHD Modes

    NASA Astrophysics Data System (ADS)

    Comer, K. J.; Callen, J. D.; Hegna, C. C.; Garstka, G. D.; Turnbull, A. D.; Garofalo, A. M.; Cowley, S. C.

    2002-11-01

    Traditionally, numerical parameter scans are performed to study the effects of equilibrium shaping and profiles on long wavelength ideal MHD instabilities. Previously, we introduced a new perturbative technique to more efficiently explore these dependencies: changes in delta-W due to small equilibrium variations are found using a perturbation of the energy principle rather than with an eigenvalue-solver instability code. With this approach, the stability properties of similar equilibria can be efficiently explored without generating complete numerical results for every set of parameters (which is time-intensive for accurate representations of several configurations). Here, we apply this approach to toroidal geometry using GATO (an ideal MHD stability code) and experimental equilibria. In particular, we explore ideal MHD stability of external kink modes in the spherical tokamak Pegasus and resistive wall modes in DIII-D.

  12. Mathematical modelling in MHD technology

    SciTech Connect

    Scheindlin, A.E.; Medin, S.A. )

    1990-01-01

    The technological scheme and the general parameters of the commercial scale pilot MHD power plant are described. The characteristics of the flow train components and the electrical equipment are discussed. The basic ideas of the mathematical modelling of the processes and the devices operation in MHD systems are considered. The application of different description levels in computer simulation is analyzed and the examples of typical solutions are presented.

  13. Antimicrobial characterisation of CEM-101 activity against respiratory tract pathogens, including multidrug-resistant pneumococcal serogroup 19A isolates.

    PubMed

    Farrell, David J; Sader, Helio S; Castanheira, Mariana; Biedenbach, Douglas J; Rhomberg, Paul R; Jones, Ronald N

    2010-06-01

    CEM-101 is a novel fluorinated macrolide-ketolide with potent activity against bacterial pathogens that are susceptible or resistant to other macrolide-lincosamide-streptogramin B (MLS(B))-ketolide agents. CEM-101 is being developed for oral and parenteral use in moderate to moderately severe community-acquired bacterial pneumonia. The objective of this study was to assess the activity of CEM-101 and comparators against contemporary respiratory tract infection (RTI) isolates. A worldwide sample of organisms was used, including Streptococcus pneumoniae [n=168; 59.3% erythromycin-resistant and 18 multidrug-resistant (MDR) serogroup 19A strains], Moraxella catarrhalis (n=21; 11 beta-lactamase positive), Haemophilus influenzae (n=100; 48 beta-lactamase positive), Haemophilus parainfluenzae and Haemophilus haemolyticus (n=12), and Legionella pneumophila (n=30). Testing and interpretation were performed using reference Clinical and Laboratory Standards Institute methods. CEM-101 was very potent against S. pneumoniae [minimum inhibitory concentration for 90% of the organisms (MIC90)=0.25 mg/L; highest MIC at 0.5 mg/L] and was 2- and > or =32-fold more active than telithromycin and clindamycin, respectively. CEM-101 also demonstrated potent activity against S. pneumoniae MDR-19A strains (MIC90=0.5 mg/L). CEM-101 was the most potent antimicrobial agent tested against L. pneumophila, with all MIC values at < or = 0.015 mg/L (telithromycin MIC90=0.03 mg/L). CEM-101 was as potent as azithromycin against Haemophilus spp. RTI pathogens (MIC90=2 mg/L), with no variations for beta-lactamase production. CEM-101 MIC values against M. catarrhalis were all at < or =0.5mg/L. Interestingly, CEM-101 potency was ca. 6 log(2) dilutions greater than telithromycin MIC results among 44 beta-haemolytic streptococci having telithromycin MICs > or = 2 mg/L. CEM-101 exhibited the greatest potency and widest spectrum of activity against RTI pathogens among the tested MLS(B)-ketolide agents

  14. Dynamo action in dissipative, forced, rotating MHD turbulence

    NASA Astrophysics Data System (ADS)

    Shebalin, John V.

    2016-06-01

    Magnetohydrodynamic (MHD) turbulence is an inherent feature of large-scale, energetic astrophysical and geophysical magnetofluids. In general, these are rotating and are energized through buoyancy and shear, while viscosity and resistivity provide a means of dissipation of kinetic and magnetic energy. Studies of unforced, rotating, ideal (i.e., non-dissipative) MHD turbulence have produced interesting results, but it is important to determine how these results are affected by dissipation and forcing. Here, we extend our previous work and examine dissipative, forced, and rotating MHD turbulence. Incompressibility is assumed, and finite Fourier series represent turbulent velocity and magnetic field on a 643 grid. Forcing occurs at an intermediate wave number by a method that keeps total energy relatively constant and allows for injection of kinetic and magnetic helicity. We find that 3-D energy spectra are asymmetric when forcing is present. We also find that dynamo action occurs when forcing has either kinetic or magnetic helicity, with magnetic helicity injection being more important. In forced, dissipative MHD turbulence, the dynamo manifests itself as a large-scale coherent structure that is similar to that seen in the ideal case. These results imply that MHD turbulence, per se, may play a fundamental role in the creation and maintenance of large-scale (i.e., dipolar) stellar and planetary magnetic fields.

  15. Dynamo theory and liquid metal MHD experiments

    NASA Astrophysics Data System (ADS)

    Lielausis, O.

    1994-06-01

    High values of magnetic Reynolds number Rm are characteristic not only to astrophysics, but also to other interesting objects, including liquid metal (LM) flows. LM experiments have been performed illustrating important predictions of the dynamo theory, for example, about the existence and features of the alpha effect. Consideration of so called 'laminar' dynamos provides a theoretical base for direct experimental realization and examination of the dynamo process. First step results, gathered a subcritical conditions, confirm the statement that self-excitation in LM experiments can be achieved practically today. In such devices as LM (sodium) cooled fast breeders Rm can reach values of up to 50 and specific MHD phenomena have been observed in operating fast reactors. Cautions against crisis like processes have been expressed. It is important for the dynamo theory to understand what kind of perturbed motion is able to coexist with the generated magnetic field. Fundamentally new ideas here are issuing from the theory of 2D MHD turbulence. LM MHD served for the first direct proves, confirming, that the predicted surprising features of 2D turbulence can be observed in reality. It is worth incorporating these already not new ideas in the dynamo theory. In such a way a field for new solutions could be established.

  16. The Biermann catastrophe of numerical MHD

    NASA Astrophysics Data System (ADS)

    Graziani, C.; Tzeferacos, P.; Lee, D.; Lamb, D. Q.; Weide, K.; Fatenejad, M.; Miller, J.

    2016-05-01

    The Biermann Battery effect is frequently invoked in cosmic magnetogenesis and studied in High-Energy Density laboratory physics experiments. Unfortunately, direct implementation of the Biermann effect in MHD codes is known to produce unphysical magnetic fields at shocks whose value does not converge with resolution. We show that this convergence breakdown is due to naive discretization, which fails to account for the fact that discretized irrotational vector fields have spurious solenoidal components that grow without bound near a discontinuity. We show that careful consideration of the kinetics of ion viscous shocks leads to a formulation of the Biermann effect that gives rise to a convergent algorithm. We note a novel physical effect a resistive magnetic precursor in which Biermann-generated field in the shock “leaks” resistively upstream. The effect appears to be potentially observable in experiments at laser facilities.

  17. Coronal extension of the MURaM radiative MHD code: From quiet sun to flare simulations

    NASA Astrophysics Data System (ADS)

    Rempel, Matthias D.; Cheung, Mark

    2016-05-01

    We present a new version of the MURaM radiative MHD code, which includes a treatment of the solar corona in terms of MHD, optically thin radiative loss and field-aligned heat conduction. In order to relax the severe time-step constraints imposed by large Alfven velocities and heat conduction we use a combination of semi-relativistic MHD with reduced speed of light ("Boris correction") and a hyperbolic formulation of heat conduction. We apply the numerical setup to 4 different setups including a mixed polarity quiet sun, an open flux region, an arcade solution and an active region setup and find all cases an amount of coronal heating sufficient to maintain a corona with temperatures from 1 MK (quiet sun) to 2 MK (active region, arcade). In all our setups the Poynting flux is self-consistently created by photospheric and sub-photospheric magneto-convection in the lower part of our simulation domain. Varying the maximum allowed Alfven velocity ("reduced speed of light") leads to only minor changes in the coronal structure as long as the limited Alfven velocity remains larger than the speed of sound and about 1.5-3 times larger than the peak advection velocity. We also found that varying details of the numerical diffusivities that govern the resistive and viscous energy dissipation do not strongly affect the overall coronal heating, but the ratio of resistive and viscous energy dependence is strongly dependent on the effective numerical magnetic Prandtl number. We use our active region setup in order to simulate a flare triggered by the emergence of a twisted flux rope into a pre-existing bipolar active region. Our simulation yields a series of flares, with the strongest one reaching GOES M1 class. The simulation reproduces many observed properties of eruptions such as flare ribbons, post flare loops and a sunquake.

  18. An advanced implicit solver for MHD

    NASA Astrophysics Data System (ADS)

    Udrea, Bogdan

    A new implicit algorithm has been developed for the solution of the time-dependent, viscous and resistive single fluid magnetohydrodynamic (MHD) equations. The algorithm is based on an approximate Riemann solver for the hyperbolic fluxes and central differencing applied on a staggered grid for the parabolic fluxes. The algorithm employs a locally aligned coordinate system that allows the solution to the Riemann problems to be solved in a natural direction, normal to cell interfaces. The result is an original scheme that is robust and reduces the complexity of the flux formulas. The evaluation of the parabolic fluxes is also implemented using a locally aligned coordinate system, this time on the staggered grid. The implicit formulation employed by WARP3 is a two level scheme that was applied for the first time to the single fluid MHD model. The flux Jacobians that appear in the implicit scheme are evaluated numerically. The linear system that results from the implicit discretization is solved using a robust symmetric Gauss-Seidel method. The code has an explicit mode capability so that implementation and test of new algorithms or new physics can be performed in this simpler mode. Last but not least the code was designed and written to run on parallel computers so that complex, high resolution runs can be per formed in hours rather than days. The code has been benchmarked against analytical and experimental gas dynamics and MHD results. The benchmarks consisted of one-dimensional Riemann problems and diffusion dominated problems, two-dimensional supersonic flow over a wedge, axisymmetric magnetoplasmadynamic (MPD) thruster simulation and three-dimensional supersonic flow over intersecting wedges and spheromak stability simulation. The code has been proven to be robust and the results of the simulations showed excellent agreement with analytical and experimental results. Parallel performance studies showed that the code performs as expected when run on parallel

  19. MHD Integrated Topping Cycle Project

    SciTech Connect

    Not Available

    1992-03-01

    The Magnetohydrodynamics (MHD) Integrated Topping Cycle (ITC) Project represents the culmination of the proof-of-concept (POC) development stage in the US Department of Energy (DOE) program to advance MHD technology to early commercial development stage utility power applications. The project is a joint effort, combining the skills of three topping cycle component developers: TRW, Avco/TDS, and Westinghouse. TRW, the prime contractor and system integrator, is responsible for the 50 thermal megawatt (50 MW{sub t}) slagging coal combustion subsystem. Avco/TDS is responsible for the MHD channel subsystem (nozzle, channel, diffuser, and power conditioning circuits), and Westinghouse is responsible for the current consolidation subsystem. The ITC Project will advance the state-of-the-art in MHD power systems with the design, construction, and integrated testing of 50 MW{sub t} power train components which are prototypical of the equipment that will be used in an early commercial scale MHD utility retrofit. Long duration testing of the integrated power train at the Component Development and Integration Facility (CDIF) in Butte, Montana will be performed, so that by the early 1990's, an engineering data base on the reliability, availability, maintainability and performance of the system will be available to allow scaleup of the prototypical designs to the next development level. This Sixteenth Quarterly Technical Progress Report covers the period May 1, 1991 to July 31, 1991.

  20. Acylation of SC4 dodecapeptide increases bactericidal potency against Gram-positive bacteria, including drug-resistant strains.

    PubMed Central

    Lockwood, Nathan A; Haseman, Judith R; Tirrell, Matthew V; Mayo, Kevin H

    2004-01-01

    We have conjugated dodecyl and octadecyl fatty acids to the N-terminus of SC4, a potently bactericidal, helix-forming peptide 12-mer (KLFKRHLKWKII), and examined the bactericidal activities of the resultant SC4 'peptide-amphiphile' molecules. SC4 peptide-amphiphiles showed up to a 30-fold increase in bactericidal activity against Gram-positive strains (Staphylococcus aureus, Streptococcus pyogenes and Bacillus anthracis), including S. aureus strains resistant to conventional antibiotics, but little or no increase in bactericidal activity against Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). Fatty acid conjugation improved endotoxin (lipopolysaccharide) neutralization by 3- to 6-fold. Although acylation somewhat increased lysis of human erythrocytes, it did not increase lysis of endothelial cells, and the haemolytic effects occurred at concentrations 10- to 100-fold higher than those required for bacterial cell lysis. For insight into the mechanism of action of SC4 peptide-amphiphiles, CD, NMR and fluorescence spectroscopy studies were performed in micelle and liposome models of eukaryotic and bacterial cell membranes. CD indicated that SC4 peptide-amphiphiles had the strongest helical tendencies in liposomes mimicking bacterial membranes, and strong membrane integration of the SC4 peptide-amphiphiles was observed using tryptophan fluorescence spectroscopy under these conditions; results that correlated with the increased bactericidal activities of SC4 peptide-amphiphiles. NMR structural analysis in micelles demonstrated that the two-thirds of the peptide closest to the fatty acid tail exhibited a helical conformation, with the positively-charged side of the amphipathic helix interacting more with the model membrane surface. These results indicate that conjugation of a fatty acid chain to the SC4 peptide enhances membrane interactions, stabilizes helical structure in the membrane-bound state and increases bactericidal potency. PMID:14609430

  1. A Study of Remitted and Treatment-Resistant Depression Using MMPI and Including Pessimism and Optimism Scales

    PubMed Central

    Suzuki, Masatoshi; Takahashi, Michio; Muneoka, Katsumasa; Sato, Koichi; Hashimoto, Kenji; Shirayama, Yukihiko

    2014-01-01

    Background The psychological aspects of treatment-resistant and remitted depression are not well documented. Methods We administered the Minnesota Multiphasic Personality Inventory (MMPI) to patients with treatment-resistant depression (n = 34), remitted depression (n = 25), acute depression (n = 21), and healthy controls (n = 64). Pessimism and optimism were also evaluated by MMPI. Results ANOVA and post-hoc tests demonstrated that patients with treatment-resistant and acute depression showed similarly high scores for frequent scale (F), hypochondriasis, depression, conversion hysteria, psychopathic device, paranoia, psychasthenia and schizophrenia on the MMPI compared with normal controls. Patients with treatment-resistant depression, but not acute depression registered high on the scale for cannot say answer. Using Student's t-test, patients with remitted depression registered higher on depression and social introversion scales, compared with normal controls. For pessimism and optimism, patients with treatment-resistant depression demonstrated similar changes to acutely depressed patients. Remitted depression patients showed lower optimism than normal controls by Student's t-test, even though these patients were deemed recovered from depression using HAM-D. Conclusions The patients with remitted depression and treatment-resistant depression showed subtle alterations on the MMPI, which may explain the hidden psychological features in these cohorts. PMID:25279466

  2. Equilibrium and MHD Activity in PEGASUS Plasmas

    NASA Astrophysics Data System (ADS)

    Garstka, G. D.

    2000-10-01

    The primary research goals of the PEGASUS toroidal experiment involve the exploration of MHD stability boundaries at high beta and extremely low aspect ratio. A novel nonlinear least-squares fitting technique is used to reconstruct equilibria; the more conventional TokaMac equilibrium code is used as well. The continuous resistive vacuum vessel is modeled as a set of inductively coupled coils for the purpose of the reconstructions. A variety of MHD phenomena have been observed on PEGASUS ohmic discharges. Internal reconnection events (IREs) are often seen. The characteristics of these events match those observed on other STs: they are observed more frequently when the machine is dirty and when the plasma is overdriven into the central column. An n=1 mode with a frequency of 3-8 kHz is often present throughout the discharge. This mode is associated with fast current ramps (> 30 MA/s) and can limit the discharge evolution. There is also substantial evidence of double tearing modes during fast current ramps. Present work involves the exploration of the edge kink stability boundary at near-unity aspect ratio.

  3. MHD stability of tokamak plasmas

    SciTech Connect

    Chance, M.S. Sun, Y.C.; Jardin, S.C.; Kessel, C.E.; Okabayashi, M.

    1992-08-01

    This paper will give an overview of the some of the methods which are used to simulate the ideal MHD properties of tokamak plasmas. A great deal of the research in this field is necessarily numerical and the substantial progress made during the past several years has roughly paralleled the continuing availability of more advanced supercomputers. These have become essential to accurately model the complex configurations necessary for achieving MHD stable reactor grade conditions. Appropriate tokamak MHD equilibria will be described. Then the stability properties is discussed in some detail, emphasizing the difficulties of obtaining stable high {beta} discharges in plasmas in which the current is mainly ohmically driven and thus demonstrating the need for tailoring the current and pressure profiles of the plasma away from the ohmic state. The outline of this paper will roughly follow the physics development to attain the second region of stability in the PBX-M device at The Princeton Plasmas Physics Laboratory.

  4. Ex Vivo Activity of Endoperoxide Antimalarials, Including Artemisone and Arterolane, against Multidrug-Resistant Plasmodium falciparum Isolates from Cambodia

    PubMed Central

    Chaorattanakawee, Suwanna; Lon, Chanthap; Saunders, David L.; Rutvisuttinunt, Wiriya; Yingyuen, Kritsanai; Bathurst, Ian; Ding, Xavier C.; Tyner, Stuart D.

    2014-01-01

    Novel synthetic endoperoxides are being evaluated as new components of artemisinin combination therapies (ACTs) to treat artemisinin-resistant Plasmodium falciparum malaria. We conducted blinded ex vivo activity testing of fully synthetic (OZ78 and OZ277) and semisynthetic (artemisone, artemiside, artesunate, and dihydroartemisinin) endoperoxides in the histidine-rich protein 2 enzyme-linked immunosorbent assay against 200 P. falciparum isolates from areas of artemisinin-resistant malaria in western and northern Cambodia in 2009 and 2010. The order of potency and geometric mean (GM) 50% inhibitory concentrations (IC50s) were as follows: artemisone (2.40 nM) > artesunate (8.49 nM) > dihydroartemisinin (11.26 nM) > artemiside (15.28 nM) > OZ277 (31.25 nM) > OZ78 (755.27 nM). Ex vivo activities of test endoperoxides positively correlated with dihydroartemisinin and artesunate. The isolates were over 2-fold less susceptible to dihydroartemisinin than the artemisinin-sensitive P. falciparum W2 clone and showed sensitivity comparable to those with test endoperoxides and artesunate, with isolate/W2 IC50 susceptibility ratios of <2.0. All isolates had P. falciparum chloroquine resistance transporter mutations, with negative correlations in sensitivity to endoperoxides and chloroquine. The activities of endoperoxides (artesunate, dihydroartemisinin, OZ277, and artemisone) significantly correlated with that of the ACT partner drug, mefloquine. Isolates had mutations associated with clinical resistance to mefloquine, with 35% prevalence of P. falciparum multidrug resistance gene 1 (pfmdr1) amplification and 84.5% occurrence of the pfmdr1 Y184F mutation. GM IC50s for mefloquine, lumefantrine, and endoperoxides (artesunate, dihydroartemisinin, OZ277, OZ78, and artemisone) correlated with pfmdr1 copy number. Given that current ACTs are failing potentially from reduced sensitivity to artemisinins and partner drugs, newly identified mutations associated with artemisinin resistance

  5. Seawater is a reservoir of multi-resistant Escherichia coli, including strains hosting plasmid-mediated quinolones resistance and extended-spectrum beta-lactamases genes

    PubMed Central

    Alves, Marta S.; Pereira, Anabela; Araújo, Susana M.; Castro, Bruno B.; Correia, António C. M.; Henriques, Isabel

    2014-01-01

    The aim of this study was to examine antibiotic resistance (AR) dissemination in coastal water, considering the contribution of different sources of fecal contamination. Samples were collected in Berlenga, an uninhabited island classified as Natural Reserve and visited by tourists for aquatic recreational activities. To achieve our aim, AR in Escherichia coli isolates from coastal water was compared to AR in isolates from two sources of fecal contamination: human-derived sewage and seagull feces. Isolation of E. coli was done on Chromocult agar. Based on genetic typing 414 strains were established. Distribution of E. coli phylogenetic groups was similar among isolates of all sources. Resistances to streptomycin, tetracycline, cephalothin, and amoxicillin were the most frequent. Higher rates of AR were found among seawater and feces isolates, except for last-line antibiotics used in human medicine. Multi-resistance rates in isolates from sewage and seagull feces (29 and 32%) were lower than in isolates from seawater (39%). Seawater AR profiles were similar to those from seagull feces and differed significantly from sewage AR profiles. Nucleotide sequences matching resistance genes blaTEM, sul1, sul2, tet(A), and tet(B), were present in isolates of all sources. Genes conferring resistance to 3rd generation cephalosporins were detected in seawater (blaCTX-M-1 and blaSHV-12) and seagull feces (blaCMY-2). Plasmid-mediated determinants of resistance to quinolones were found: qnrS1 in all sources and qnrB19 in seawater and seagull feces. Our results show that seawater is a relevant reservoir of AR and that seagulls are an efficient vehicle to spread human-associated bacteria and resistance genes. The E. coli resistome recaptured from Berlenga coastal water was mainly modulated by seagulls-derived fecal pollution. The repertoire of resistance genes covers antibiotics critically important for humans, a potential risk for human health. PMID:25191308

  6. Travelers Can Import Colistin-Resistant Enterobacteriaceae, Including Those Possessing the Plasmid-Mediated mcr-1 Gene.

    PubMed

    Bernasconi, Odette J; Kuenzli, Esther; Pires, João; Tinguely, Regula; Carattoli, Alessandra; Hatz, Christoph; Perreten, Vincent; Endimiani, Andrea

    2016-08-01

    Stool samples from 38 travelers returning from India were screened for extended-spectrum cephalosporin- and carbapenem-resistant Enterobacteriaceae implementing standard selective plates. Twenty-six (76.3%) people were colonized with CTX-M or DHA producers, but none of the strains was colistin resistant and/or mcr-1 positive. Nevertheless, using overnight enrichment and CHROMagar Orientation plates supplemented with colistin, four people (10.5%) were found to be colonized with colistin-resistant Escherichia coli One cephalosporin-susceptible sequence type 10 (ST10) strain carried a 4,211-bp ISApl1-mcr-1-ISApl1 element in an IncHI2 plasmid backbone. PMID:27297483

  7. Multiphysics/Multiscale Coupling of Microturbulence and MHD Equiliria

    NASA Astrophysics Data System (ADS)

    Lee, W. W.; Startsev, E. A.; Hudson, S. R.; Wang, W. X.; Ethier, S.

    2015-11-01

    We propose to investigate the multiphysics and multiscale coupling between a time-dependent gyrokinetic ``microscopic'' code for studying gyroradius-scale turbulence, associated with global ion-acoustic and shear-Alfven waves, and a ``macroscopic'' code for computing large-scale global equilibria based on the time-independent MHD equations, in order to identify a family of self-consistent global MHD equilibria that can minimize the electrostatic potentials responsible for turbulent transport by passing global parameters between the two codes. The codes involved are 1) the electromagnetic version of the GTS code for studying microturbulence, and 2) the SPEC code for calculating three-dimensional MHD equilibria with or without chaotic fields. This concept is based on a newly found correlation between the gyrokinetic evolution and the MHD equilibrium when the electrostatic potential vanishes. The proposed work involves the scales ranging from the electron skin depth to the machine size, and includes the physics of both gyrokinetics and MHD. This work is supported by US DoE # DE-AC02-09CH11466.

  8. Wall surface leakage effects on MHD power generator performance

    SciTech Connect

    Pian, C.C.P.; Schmitt, E.W.

    1994-12-31

    Internal surface leakage effects on the MHD generator performance were studied using a combined experimental and analytical approach. A method to determine the wall resistances and slag layer conductivities from seed shut-off test data is introduced. These measured resistance values are then utilized in generator performance analyses. Calculated results were compared with measured data from MHD generator tests to verify the modeling approach. Finally, these calculated results were used to investigate the distribution of internal leakage currents as a function of generator size, generator operating conditions, and iron oxide injection rates. An advantage of this analysis methodology is the ability to differentiate between wall leakage and apparent leakage effects in the measured test data.

  9. Corrosion and arc erosion in MHD channels

    SciTech Connect

    Rosa, R.J. . Dept. of Mechanical Engineering); Pollina, R.J. . Dept. of Mechanical Engineering Avco-Everett Research Lab., Everett, MA )

    1991-10-01

    The objective of this task is to study the corrosion and arc erosion of MHD materials in a cooperative effort with, and to support, the MHD topping cycle program. Materials tested in the Avco Research Laboratory/Textron facility, or materials which have significant MHD importance, will be analyzed to document their physical deterioration. Conclusions shall be drawn about their wear mechanisms and lifetime in the MHD environment with respect to the following issues; sulfur corrosion, electrochemical corrosion, and arc erosion. The impact of any materials or slag conditions on the level of power output and on the level of leakage current in the MHD channel will also be noted, where appropriate.

  10. Open cycle gas fired MHD power plants

    SciTech Connect

    Medin, S.A. ); Negrini, F. )

    1991-01-01

    In this paper, the main objectives for the present development of gas fired MHD power generation are considered. The state of the world-wide natural gas consumption and its utilization for electricity production is analyzed. The experimental efforts in gas-fired MHD studies are briefly described. The essential features of the two major world gas-fired MHD project - the Ryazan MHDES-580 (U-500) power plant and the Italian 230 MWt retrofit are presented. New suggestions for improving the efficiency of MHD systems and the theoretical and experimental aspects of MHD development are discussed.

  11. Outline of fast analyzer for MHD equilibrium FAME

    NASA Astrophysics Data System (ADS)

    Sakata, Shinya; Haginoya, Hirofumi; Tsuruoka, Takuya; Aoyagi, Tetsuo; Saito, Naoyuki; Harada, Hiroo; Tani, Keiji; Watanabe, Hideto

    1994-02-01

    The FAME (Fast Analyzer for Magnetohydrodynamic (MHD) Equilibrium) system has been developed in order to provide more than 100 MHD equilibria in time series which are enough for the non-stationary analysis of the experimental data of JT-60 within about 20 minutes shot interval. The FAME is an MIMD type small scale parallel computer with 20 microprocessors which are connected by a multi-stage switching system. The maximum theoretical speed is 250 MFLOPS. For the software system of FAME, MHD equilibrium analysis code SELENE and its input data production code FBI are tuned up taking the parallel processing into consideration. Consequently, the computational performance of the FAME system becomes more than 7 times faster than the existing general purpose computer FACOM M780-10s. This report summarizes the outline of the FAME system including hardware, soft-ware and peripheral equipments.

  12. MHD Simulations of the Plasma Flow in the Magnetic Nozzle

    NASA Technical Reports Server (NTRS)

    Smith, T. E. R.; Keidar, M.; Sankaran, K.; olzin, K. A.

    2013-01-01

    The magnetohydrodynamic (MHD) flow of plasma through a magnetic nozzle is simulated by solving the governing equations for the plasma flow in the presence of an static magnetic field representing the applied nozzle. This work will numerically investigate the flow and behavior of the plasma as the inlet plasma conditions and magnetic nozzle field strength are varied. The MHD simulations are useful for addressing issues such as plasma detachment and to can be used to gain insight into the physical processes present in plasma flows found in thrusters that use magnetic nozzles. In the model, the MHD equations for a plasma, with separate temperatures calculated for the electrons and ions, are integrated over a finite cell volume with flux through each face computed for each of the conserved variables (mass, momentum, magnetic flux, energy) [1]. Stokes theorem is used to convert the area integrals over the faces of each cell into line integrals around the boundaries of each face. The state of the plasma is described using models of the ionization level, ratio of specific heats, thermal conductivity, and plasma resistivity. Anisotropies in current conduction due to Hall effect are included, and the system is closed using a real-gas equation of state to describe the relationship between the plasma density, temperature, and pressure.A separate magnetostatic solver is used to calculate the applied magnetic field, which is assumed constant for these calculations. The total magnetic field is obtained through superposition of the solution for the applied magnetic field and the self-consistently computed induced magnetic fields that arise as the flowing plasma reacts to the presence of the applied field. A solution for the applied magnetic field is represented in Fig. 1 (from Ref. [2]), exhibiting the classic converging-diverging field pattern. Previous research was able to demonstrate effects such as back-emf at a super-Alfvenic flow, which significantly alters the shape of the

  13. MHD Modeling in Complex 3D Geometries: Towards Predictive Simulation of SIHI Current Drive

    NASA Astrophysics Data System (ADS)

    Hansen, Christopher James

    The HIT-SI experiment studies Steady Inductive Helicity Injection (SIHI) for the purpose of forming and sustaining a spheromak plasma. A spheromak is formed in a nearly axisymmetric flux conserver, with a bow tie cross section, by means of two semi-toroidal injectors. The plasma-facing surfaces of the device, which are made of copper for its low resistivity, are covered in an insulating coating in order to operate in a purely inductive manner. Following formation, the spheromak flux and current are increased during a quiescent period marked by a decrease in the global mode activity. A proposed mechanism, Imposed Dynamo Current Drive (IDCD), is expected to be responsible for this phase of quiescent current drive. Due to the geometric complexity of the experiment, previous numerical modeling efforts have used a simplified geometry that excludes the injector volumes from the simulated domain. The effect of helicity injection is then modeled by boundary conditions on this reduced plasma volume. The work presented here has explored and developed more complete computational models of the HIT-SI device. This work is separated into 3 distinct but complementary areas: 1) Development of a 3D MHD equilibrium code that can incorporate the non-axisymmetric injector fields present in HIT-SI and investigation of equilibria of interest during spheromak sustainment. 2) A 2D axisymmetric MHD equilibrium code that was used to explore reduced order models for mean-field evolution using equations derived from IDCD theory including coupling to 3D equilibria. 3) A 3D time-dependent non-linear MHD code that is capable of modeling the entire plasma volume including dynamics within the injectors. Although HIT-SI was the motivation for, and experiment studied in this research, the tools and methods developed are general --- allowing their application to a broad range of magnetic confinement experiments. These tools constitute a significant advance for modeling plasma dynamics in devices with

  14. Adaptive Numerical Dissipative Control in High Order Schemes for Multi-D Non-Ideal MHD

    NASA Technical Reports Server (NTRS)

    Yee, H. C.; Sjoegreen, B.

    2004-01-01

    The goal is to extend our adaptive numerical dissipation control in high order filter schemes and our new divergence-free methods for ideal MHD to non-ideal MHD that include viscosity and resistivity. The key idea consists of automatic detection of different flow features as distinct sensors to signal the appropriate type and amount of numerical dissipation/filter where needed and leave the rest of the region free of numerical dissipation contamination. These scheme-independent detectors are capable of distinguishing shocks/shears, flame sheets, turbulent fluctuations and spurious high-frequency oscillations. The detection algorithm is based on an artificial compression method (ACM) (for shocks/shears), and redundant multi-resolution wavelets (WAV) (for the above types of flow feature). These filter approaches also provide a natural and efficient way for the minimization of Div(B) numerical error. The filter scheme consists of spatially sixth order or higher non-dissipative spatial difference operators as the base scheme for the inviscid flux derivatives. If necessary, a small amount of high order linear dissipation is used to remove spurious high frequency oscillations. For example, an eighth-order centered linear dissipation (AD8) might be included in conjunction with a spatially sixth-order base scheme. The inviscid difference operator is applied twice for the viscous flux derivatives. After the completion of a full time step of the base scheme step, the solution is adaptively filtered by the product of a 'flow detector' and the 'nonlinear dissipative portion' of a high-resolution shock-capturing scheme. In addition, the scheme independent wavelet flow detector can be used in conjunction with spatially compact, spectral or spectral element type of base schemes. The ACM and wavelet filter schemes using the dissipative portion of a second-order shock-capturing scheme with sixth-order spatial central base scheme for both the inviscid and viscous MHD flux

  15. Numerical Simulation of Turbulent MHD Flows Using an Iterative PNS Algorithm

    NASA Technical Reports Server (NTRS)

    Kato, Hiromasa; Tannehill, John C.; Mehta, Unmeel B.

    2003-01-01

    A new parabolized Navier-Stokes (PNS) algorithm has been developed to efficiently compute magnetohydrodynamic (MHD) flows in the low magnetic Reynolds number regime. In this regime, the electrical conductivity is low and the induced magnetic field is negligible compared to the applied magnetic field. The MHD effects are modeled by introducing source terms into the PNS equation which can then be solved in a very efficient manner. To account for upstream (elliptic) effects, the flowfields are computed using multiple streamwise sweeps with an iterated PNS algorithm. Turbulence has been included by modifying the Baldwin-Lomax turbulence model to account for MHD effects. The new algorithm has been used to compute both laminar and turbulent, supersonic, MHD flows over flat plates and supersonic viscous flows in a rectangular MHD accelerator. The present results are in excellent agreement with previous complete Navier-Stokes calculations.

  16. Coal-gasification/MHD/steam-turbine combined-cycle (GMS) power generation

    SciTech Connect

    Lytle, J.M.; Marchant, D.D.

    1980-11-01

    The coal-gasification/MHD/steam-turbine combined cycle (GMS) refers to magnetohydrodynamic (MHD) systems in which coal gasification is used to supply a clean fuel (free of mineral matter and sulfur) for combustion in an MHD electrical power plant. Advantages of a clean-fuel system include the elimination of mineral matter or slag from all components other than the coal gasifier and gas cleanup system; reduced wear and corrosion on components; and increased seed recovery resulting from reduced exposure of seed to mineral matter or slag. Efficiencies in some specific GMS power plants are shown to be higher than for a comparably sized coal-burning MHD power plant. The use of energy from the MHD exhaust gas to gasify coal (rather than the typical approach of burning part of the coal) results in these higher efficiencies.

  17. Global MHD Simulations of Space Plasma Environments: Heliosphere, Comets, Magnetospheres of Plants and Satellites

    NASA Technical Reports Server (NTRS)

    Kabin, K.; Hansen, K. C.; Gombosi, T. I.; Combi, M. R.; Linde, T. J.; DeZeeuw, D. L.; Groth, C. P. T.; Powell, K. G.; Nagy, A. F.

    2000-01-01

    Magnetohydrodynamics (MHD) provides an approximate description of a great variety of processes in space physics. Accurate numerical solutions of the MHD equations are still a challenge, but in the past decade a number of robust methods have appeared. Once these techniques made the direct solution of MHD equations feasible, a number of global three-dimensional models were designed and applied to many space physics objects. The range of these objects is truly astonishing, including active galactic nuclei, the heliosphere, the solar corona, and the solar wind interaction with planets, satellites, and comets. Outside the realm of space physics, MHD theory has been applied to such diverse problems as laboratory plasmas and electromagnetic casting of liquid metals. In this paper we present a broad spectrum of models of different phenomena in space science developed in the recent years at the University of Michigan. Although the physical systems addressed by these models are different, they all use the MHD equations as a unifying basis.

  18. GRADSPMHD: A parallel MHD code based on the SPH formalism

    NASA Astrophysics Data System (ADS)

    Vanaverbeke, S.; Keppens, R.; Poedts, S.

    2014-03-01

    We present GRADSPMHD, a completely Lagrangian parallel magnetohydrodynamics code based on the SPH formalism. The implementation of the equations of SPMHD in the “GRAD-h” formalism assembles known results, including the derivation of the discretized MHD equations from a variational principle, the inclusion of time-dependent artificial viscosity, resistivity and conductivity terms, as well as the inclusion of a mixed hyperbolic/parabolic correction scheme for satisfying the ∇ṡB→ constraint on the magnetic field. The code uses a tree-based formalism for neighbor finding and can optionally use the tree code for computing the self-gravity of the plasma. The structure of the code closely follows the framework of our parallel GRADSPH FORTRAN 90 code which we added previously to the CPC program library. We demonstrate the capabilities of GRADSPMHD by running 1, 2, and 3 dimensional standard benchmark tests and we find good agreement with previous work done by other researchers. The code is also applied to the problem of simulating the magnetorotational instability in 2.5D shearing box tests as well as in global simulations of magnetized accretion disks. We find good agreement with available results on this subject in the literature. Finally, we discuss the performance of the code on a parallel supercomputer with distributed memory architecture. Catalogue identifier: AERP_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AERP_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 620503 No. of bytes in distributed program, including test data, etc.: 19837671 Distribution format: tar.gz Programming language: FORTRAN 90/MPI. Computer: HPC cluster. Operating system: Unix. Has the code been vectorized or parallelized?: Yes, parallelized using MPI. RAM: ˜30 MB for a

  19. A kinetic-MHD model for low frequency phenomena

    SciTech Connect

    Cheng, C.Z.

    1991-07-01

    A hybrid kinetic-MHD model for describing low-frequency phenomena in high beta anisotropic plasmas that consist of two components: a low energy core component and an energetic component with low density. The kinetic-MHD model treats the low energy core component by magnetohydrodynamic (MHD) description, the energetic component by kinetic approach such as the gyrokinetic equation, and the coupling between the dynamics of these two components through plasma pressure in the momentum equation. The kinetic-MHD model optimizes both the physics contents and the theoretical efforts in studying low frequency MHD waves and transport phenomena in general magnetic field geometries, and can be easily modified to include the core plasma kinetic effects if necessary. It is applicable to any magnetized collisionless plasma system where the parallel electric field effects are negligibly small. In the linearized limit two coupled eigenmode equations for describing the coupling between the transverse Alfven type and the compressional Alfven type waves are derived. The eigenmode equations are identical to those derived from the full gyrokinetic equation in the low frequency limit and were previously analyzed both analytically nd numerically to obtain the eigenmode structure of the drift mirror instability which explains successfully the multi-satellite observation of antisymmetric field-aligned structure of the compressional magnetic field of Pc 5 waves in the magnetospheric ring current plasma. Finally, a quadratic form is derived to demonstrate the stability of the low-frequency transverse and compressional Alfven type instabilities in terms of the pressure anisotropy parameter {tau} and the magnetic field curvature-pressure gradient parameter. A procedure for determining the stability of a marginally stable MHD wave due to wave-particle resonances is also presented.

  20. Hall MHD Simulations of Comet 67P/Churyumov-Gerasimenko

    NASA Astrophysics Data System (ADS)

    Shou, Y.; Combi, M. R.; Rubin, M.; Hansen, K. C.; Toth, G.; Gombosi, T. I.

    2012-12-01

    Comets have highly eccentric orbits and a wide range of gas production rates and thus they are ideal subjects to study the interaction between the solar wind and nonmagnetized bodies. Hansen et al. (2007, Space Sci. Rev. 128, 133) used a fluid-based MHD model and a semi-kinetic hybrid particle model to study the plasma environment of comet 67P/Churyumov-Gerasimenko (CG), the Rosetta mission target comet, at different heliocentric distances. They showed that for such a weak comet at a large heliocentric distance, the length scales of the cometosheath and the bow shock are comparable to or smaller than the ion gyroradius, which violates the underlying assumption for a valid fluid description of the plasma. As a result, the classical ideal MHD model is not able to always give physical results, while the hybrid model, which accounts for the kinetic effects of ions with both cometary and solar wind origin, is more reliable. However, hybrid models are computationally expensive and the results can be noisy. A compromise approach is Hall MHD [Toth et al., 2008], which includes the Hall term in the MHD equations and allows for the decoupling of the ion and electron fluids. We use a single ion species Hall MHD model to simulate the plasma environment of comet 67P/CG and compare the results with the two models mentioned above. We find that the Hall effect is capable of reproducing some features of the hybrid model and thus extends the applicability of MHD. In addition, this study helps to identify the conditions and regions in the cometary plasma where the Hall effect is not negligible. This work is supported by NSF Planetary Astronomy grant AST0707283 and JPL subcontract 1266313 under NASA grant NMO710889.

  1. Develop and test an Internally Cooled, Cabled Superconductor (ICCS) for large scale MHD magnets: Analysis report

    NASA Astrophysics Data System (ADS)

    Hatch, A. M.; Marston, P. G.; Tarrh, J. M.; Becker, H.; Dawson, A. M.; Minervini, J. V.

    1986-01-01

    A three-year program to develop and test an internally-cooled cabled superconductor (ICCS) for large-scale MHD magnets is being performed by MIT for the Pittsburgh Energy Technology Center (PETC) under contract DE-AC22-84PC70512. Included in this report are electromagnetic, thermodynamic, structural, protection, and systems analyses, completed as required to substantiate the preliminary conductor design requirements definition and the associated preconceptual magnet design developed in Task 1. Copper-stabilized NbTi superconductor was selected at the outset as being most suitable for the application. The analysis necessary to substantiate the preconceptual MHD magnet design is complete, including field and force calculations, preliminary structural analysis, thermodynamic (cryogenic) analysis, and the analysis of the magnet electrical and protective systems. A significant result of the field analysis is the determination that maximum fields to which the conductor is exposed in the magnet are considerably higher than originally expected. Changes were made to produce a revised design in which the maximum field is 6.9T (53% above central field) and adequate stability is ensured. Analysis necessary to substantiate a preliminary conductor design requirement definition for full-scale conductor has been completed except that further work is required to establish maximum allowable internal flow resistance and maximum length between vents. Procedures for accomplishing these analyses have already been developed at MIT and by other contractors.

  2. Stabilization of the external kink and other MHD issues. Summary report

    SciTech Connect

    Freidberg, J.P.; Goldston, R.J.; Jardin, S.C.; Neilson, G.H.; Rosenbluth, M.N.; Taylor, T.S.; Thomassen, K.I.

    1993-08-13

    An MHD workshop entitled ``Stabilization of the External Kink and Other MHD Issues`` was held June 1993. This is a summary report of activities at that workshop, structured to respond to the three questions in the charge (letter from J. Willis). The experimental and theoretical status of these issues, and the R&D needs in each area, are addressed. We discuss the potential impact on the TPX and ITER programs of these issues. The workshop participants came from a broad and diverse range of institutions in the fusion program, including international participants. As a result, we believe the summary here reflects some consensus of the community on these very important program issues, and that the TPX and ITER programs will benefit from these discussions. The title of the workshop was chosen to indicate both our knowledge and our uncertainty of MHD phenomena limiting {beta} and causing disruptions in tokamaks. The purpose was to bring together theorists and experimentalist in order to assess our current understanding of the external kink instability at high {beta}, and to assess the potential for passive or active stabilization of the dominant modes. We also outlined the R&D needed for TPX and other future devices. Not only was the preworkshop theory clearly presented, but significant new theoretical results were described for the first time, emphasizing the roles of the resistivity of the cold edge plasma and of the plasma toroidicity in the stability criteria. Excellent reviews of the effects of the vessel walls on plasma stability were given as related to the DIII-D, TFTR, JET, PBX-M, and HBT-EP experiments. These results are generally consistent with the more complete theory.

  3. Broken Ergodicity in MHD Turbulence

    NASA Technical Reports Server (NTRS)

    Shebalin, John V.

    2010-01-01

    Ideal magnetohydrodynamic (MHD) turbulence may be represented by finite Fourier series, where the inherent periodic box serves as a surrogate for a bounded astrophysical plasma. Independent Fourier coefficients form a canonical ensemble described by a Gaussian probability density function containing a Hermitian covariance matrix with positive eigenvalues. The eigenvalues at lowest wave number can be very small, resulting in a large-scale coherent structure: a turbulent dynamo. This is seen in computations and a theoretical explanation in terms of 'broken ergodicity' contains Taylor s theory of force-free states. An important problem for future work is the case of real, i.e., dissipative flows. In real flows, broken ergodicity and coherent structure are still expected to occur in MHD turbulence at the largest scale, as suggested by low resolution simulations. One challenge is to incorporate coherent structure at the largest scale into the theory of turbulent fluctuations at smaller scales.

  4. Shocked Magnetotail: ARTEMIS Observations and MHD Simulations

    NASA Astrophysics Data System (ADS)

    Zhou, Xiaoyan

    2015-04-01

    Interplanetary shocks can cause magnetospheric disturbances on various scales including kinetic and MHD processes. In this paper we study a shock event using ARTEMIS in situ observations and OpenGGCM MHD simulations, which shows how significant effect of interplanetary shocks could be on the magnetotail. The two ARTEMIS spacecraft were located near the tail current sheet and lobe center at (-60, 1, -5Re_GSM) when the shock arrived and recorded an abrupt tail compression leading to significant enhancements in the plasma density, temperature, magnetic field strength, and cross-tail current density, as well as to tailward flows and current sheet crossings. About 10 min later, the spacecraft entered the sheath solar wind unexpectedly. Two hypotheses are considered: either the tail was cut off by the high solar wind ram pressure (~25-30 nPa), or the compressed tail was pushed aside by the appreciable dawnward solar wind flow imposed by the shock. OpenGGMC simulation results confirmed the second hypothesis and revealed that during this 10 min interval, the lobe center moved dawnward by ~12 Re and the tail width in Y was reduced from ~40 to 26 Re, which eventually exposed ARTEMIS to the sheath solar wind. Comparisons of plasma and magnetic parameters between ARTEMIS in situ observations and simulations showed a satisfied consistence.

  5. Alpha-Driven MHD and MHD-Induced Alpha Loss in TFTR DT Experiments

    NASA Astrophysics Data System (ADS)

    Chang, Zuoyang

    1996-11-01

    Theoretical calculation and numerical simulation indicate that there can be interesting interactions between alpha particles and MHD activity which can adversely affect the performance of a tokamak reactor (e.g., ITER). These interactions include alpha-driven MHD, like the toroidicity-induced-Alfven-eigenmode (TAE) and MHD induced alpha particle losses or redistribution. Both phenomena have been observed in recent TFTR DT experiments. Weak alpha-driven TAE activity was observed in a NBI-heated DT experiment characterized by high q0 ( >= 2) and low core magnetic shear. The TAE mode appears at ~30-100 ms after the neutral beam turning off approximately as predicted by theory. The mode has an amplitude measured by magnetic coils at the edge tildeB_p ~1 mG, frequency ~150-190 kHz and toroidal mode number ~2-3. It lasts only ~ 30-70 ms and has been seen only in DT discharges with fusion power level about 1.5-2.0 MW. Numerical calculation using NOVA-K code shows that this type of plasma has a big TAE gap. The calculated TAE frequency and mode number are close to the observation. (2) KBM-induced alpha particle loss^1. In some high-β, high fusion power DT experiments, enhanced alpha particle losses were observed to be correlated to the high frequency MHD modes with f ~100-200 kHz (the TAE frequency would be two-times higher) and n ~5-10. These modes are localized around the peak plasma pressure gradient and have ballooning characteristics. Alpha loss increases by 30-100% during the modes. Particle orbit simulations show the added loss results from wave-particle resonance. Linear instability analysis indicates that the plasma is unstable to the kinetic MHD ballooning modes (KBM) driven primarily by strong local pressure gradients. ----------------- ^1Z. Chang, et al, Phys. Rev. Lett. 76 (1996) 1071. In collaberation with R. Nazikian, G.-Y. Fu, S. Batha, R. Budny, L. Chen, D. Darrow, E. Fredrickson, R. Majeski, D. Mansfield, K. McGuire, G. Rewoldt, G. Taylor, R. White, K

  6. MHD simple waves and the divergence wave

    SciTech Connect

    Webb, G. M.; Pogorelov, N. V.; Zank, G. P.

    2010-03-25

    In this paper we investigate magnetohydrodynamic (MHD) simple divergence waves in MHD, for models in which nablacentre dotBnot =0. These models are related to the eight wave Riemann solvers in numerical MHD, in which the eighth wave is the divergence wave associated with nablacentre dotBnot =0. For simple wave solutions, all physical variables (the gas density, pressure, fluid velocity, entropy, and magnetic field induction in the MHD case) depend on a single phase function phi. We consider the form of the MHD equations used by both Powell et al. and Janhunen. It is shown that the Janhunen version of the equations possesses fully nonlinear, exact simple wave solutions for the divergence wave, but no physically meaningful simple divergence wave solution exists for the Powell et al. system. We suggest that the 1D simple, divergence wave solution for the Janhunen system, may be useful for the testing and validation of numerical MHD codes.

  7. The heat-resistant agglutinin family includes a novel adhesin from enteroaggregative Escherichia coli strain 60A.

    PubMed

    Mancini, Justin; Weckselblatt, Brooke; Chung, Yoonjie K; Durante, Julia C; Andelman, Steven; Glaubman, Jessica; Dorff, Justin D; Bhargava, Samhita; Lijek, Rebeccah S; Unger, Katherine P; Okeke, Iruka N

    2011-09-01

    Heat-resistant agglutinin 1 (Hra1) is an accessory colonization factor of enteroaggregative Escherichia coli (EAEC) strain 042. Tia, a close homolog of Hra1, is an invasin and adhesin that has been described in enterotoxigenic E. coli. We devised a PCR-restriction fragment length polymorphism screen for the associated genes and found that they occur among 55 (36.7%) of the enteroaggregative E. coli isolates screened, as well as lower proportions of enterotoxigenic, enteropathogenic, enterohemorrhagic, and commensal E. coli isolates. Overall, 25%, 8%, and 3% of 150 EAEC strains harbored hra1 alone, tia alone, or both genes, respectively. One EAEC isolate, 60A, produced an amplicon with a unique restriction profile, distinct from those of hra1 and tia. We cloned and sequenced the full-length agglutinin gene from strain 60A and have designated it hra2. The hra2 gene was not detected in any of 257 diarrheagenic E. coli isolates in our collection but is present in the genome of Salmonella enterica serovar Heidelberg strain SL476. The cloned hra2 gene from strain 60A, which encodes a predicted amino acid sequence that is 64% identical to that of Hra1 and 68% identical to that of Tia, was sufficient to confer adherence on E. coli K-12. We constructed an hra2 deletion mutant of EAEC strain 60A. The mutant was deficient in adherence but not autoaggregation or invasion, pointing to a functional distinction from the autoagglutinin Hra1 and the Tia invasin. Hra1, Tia, and the novel accessory adhesin Hra2 are members of a family of integral outer membrane proteins that confer different colonization-associated phenotypes. PMID:21764925

  8. In vitro antibacterial and chemical properties of essential oils including native plants from Brazil against pathogenic and resistant bacteria.

    PubMed

    Barbosa, Lidiane Nunes; Probst, Isabella da Silva; Andrade, Bruna Fernanda Murbach Teles; Alves, Fernanda Cristina Bérgamo; Albano, Mariana; da Cunha, Maria de Lourdes Ribeiro de Souza; Doyama, Julio Toshimi; Rall, Vera Lúcia Mores; Fernandes Júnior, Ary

    2015-01-01

    The antimicrobials products from plants have increased in importance due to the therapeutic potential in the treatment of infectious diseases. Therefore, we aimed to examine the chemical characterisation (GC-MS) of essential oils (EO) from seven plants and measure antibacterial activities against bacterial strains isolated from clinical human specimens (methicillin-resistant Staphylococcus aureus (MRSA) and sensitive (MSSA), Escherichia coli, Pseudomonas aeruginosa, Salmonella Typhimurium) and foods (Salmonella Enteritidis). Assays were performed using the minimal inhibitory concentration (MIC and MIC90%) (mg/mL) by agar dilution and time kill curve methods (log CFU/mL) to aiming synergism between EO. EO chemical analysis showed a predominance of terpenes and its derivatives. The highest antibacterial activities were with Cinnamomun zeylanicum (0.25 mg/mL on almost bacteria tested) and Caryophyllus aromaticus EO (2.40 mg/mL on Salmonella Enteritidis), and the lowest activity was with Eugenia uniflora (from 50.80 mg/mL against MSSA to 92.40 mg/mL against both Salmonella sources and P. aeruginosa) EO. The time kill curve assays revealed the occurrence of bactericide synergism in combinations of C. aromaticus and C. zeylanicum with Rosmarinus. officinalis. Thus, the antibacterial activities of the EO were large and this can also be explained by complex chemical composition of the oils tested in this study and the synergistic effect of these EO, yet requires further investigation because these interactions between the various chemical compounds can increase or reduce (antagonism effect) the inhibitory effect of essential oils against bacterial strains. PMID:25757433

  9. Conceptual design of a space-based multimegawatt MHD power system. Topical report

    SciTech Connect

    Barton, J.R.; Bernard, F.E.; Carrington, R.A.; Hanson, L.P.; Holman, R.R.

    1988-01-01

    This report presents the system requirements and design guidelines for the space based multimegawatt MHD power system conceptual design, and comprises Volume 2 of the topical report describing the Task 1 MHD Power System Conceptual Design and Development Plan. In the interest of completeness, this report includes a summary description of the MHD power system concept with the functional requirements, design scope and design objectives. Then subsequent sections present the system requirements including operational requirements, space platform/weapon system interfaces, subsystem interfaces, and design guidelines. The analytical methods used for system analysis and parametric studies are also included. A description of the MHD power system, in the standard data table format for multimegawatt space power systems, is included in the Appendices.

  10. FLASH MHD simulations of experiments that study shock-generated magnetic fields

    NASA Astrophysics Data System (ADS)

    Tzeferacos, P.; Fatenejad, M.; Flocke, N.; Graziani, C.; Gregori, G.; Lamb, D. Q.; Lee, D.; Meinecke, J.; Scopatz, A.; Weide, K.

    2015-12-01

    We summarize recent additions and improvements to the high energy density physics capabilities in FLASH, highlighting new non-ideal magneto-hydrodynamic (MHD) capabilities. We then describe 3D Cartesian and 2D cylindrical FLASH MHD simulations that have helped to design and analyze experiments conducted at the Vulcan laser facility. In these experiments, a laser illuminates a carbon rod target placed in a gas-filled chamber. A magnetic field diagnostic (called a Bdot) employing three very small induction coils is used to measure all three components of the magnetic field at a chosen point in space. The simulations have revealed that many fascinating physical processes occur in the experiments. These include megagauss magnetic fields generated by the interaction of the laser with the target via the Biermann battery mechanism, which are advected outward by the vaporized target material but decrease in strength due to expansion and resistivity; magnetic fields generated by an outward expanding shock via the Biermann battery mechanism; and a breakout shock that overtakes the first wave, the contact discontinuity between the target material and the gas, and then the initial expanding shock. Finally, we discuss the validation and predictive science we have done for this experiment with FLASH.

  11. Rapporteur report: MHD electric power plants

    NASA Technical Reports Server (NTRS)

    Seikel, G. R.

    1980-01-01

    Five US papers from the Proceedings of the Seventh International Conference on MHD Electrical Power Generation at the Massachusetts Institute of Technology are summarized. Results of the initial parametric phase of the US effort on the study of potential early commercial MHD plants are reported and aspects of the smaller commercial prototype plant termed the Engineering Test Facility are discussed. The alternative of using a disk geometry generator rather than a linear generator in baseload MHD plants is examined. Closed-cycle as well as open-cycle MHD plants are considered.

  12. Genomic markers of panitumumab resistance including ERBB2/HER2 in a phase II study of KRAS wild-type (wt) metastatic colorectal cancer (mCRC)

    PubMed Central

    Barry, Garrett S.; Cheang, Maggie C.; Chang, Hector Li; Kennecke, Hagen F.

    2016-01-01

    A prospective study was conducted to identify biomarkers associated with resistance to panitumumab monotherapy in patients with metastatic colorectal cancer (mCRC). Patients with previously treated, codon 12/13 KRAS wt, mCRC were prospectively administered panitumumab 6 mg/kg IV q2weeks. Of 34 panitumumab-treated patients, 11 (32%) had progressive disease at 8 weeks and were classified as non-responders. A Nanostring nCounter-based assay identified a 5-gene expression signature (ERBB2, MLPH, IRX3, MYRF, and KLK6) associated with panitumumab resistance (P = 0.001). Immunohistochemistry and in situ hybridization determined that the HER2 (ERBB2) protein was overexpressed in 4/11 non-responding and 0/21 responding cases (P = 0.035). Two non-responding tumors had ERBB2 gene amplification only, and one demonstrated both ERBB2 amplification and mutation. A non-codon 12/13 KRAS mutation occurred in one panitumumab-resistant patient and was mutually exclusive with ERBB2/HER2 abnormalities. This study identifies a 5-gene signature associated with non-response to single agent panitumumab, including a subgroup of non-responders with evidence of aberrant ERBB2/HER2 signaling. KRAS wt tumors resistant to EGFRi may be identified by gene signature analysis, and the HER2 pathway plays an important role in resistance to therapy. PMID:26980732

  13. MHD activity in the ISX-B tokamak: experimental results and theoretical interpretation

    SciTech Connect

    Carreras, B.A.; Dunlap, J.L.; Bell, J.D.; Charlton, L.A.; Cooper, W.A.; Dory, R.A.; Hender, T.C.; Hicks, H.R.; Holmes, J.A.; Lynch, V.E.

    1982-01-01

    The observed spectrum of MHD fluctuations in the ISX-B tokamak is clearly dominated by the n=1 mode when the q=1 surface is in the plasma. This fact agrees well with theoretical predictions based on 3-D resistive MHD calculations. They show that the (m=1; n=1) mode is then the dominant instability. It drives other n=1 modes through toroidal coupling and n>1 modes through nonlinear couplings. These theoretically predicted mode structures have been compared in detail with the experimentally measured wave forms (using arrays of soft x-ray detectors). The agreement is excellent. More detailed comparisons between theory and experiment have required careful reconstructions of the ISX-B equilibria. The equilibria so constructed have permitted a precise evaluation of the ideal MHD stability properties of ISX-B. The present results indicate that the high ..beta.. ISX-B equilibria are marginally stable to finite eta ideal MHD modes. The resistive MHD calculations also show that at finite ..beta.. there are unstable resistive pressure driven modes.

  14. System study of an MHD/gas turbine combined-cycle baseload power plant. HTGL report No. 134

    SciTech Connect

    Annen, K.D.

    1981-08-01

    The MHD/gas turbine combined-cycle system has been designed specifically for applications where the availability of cooling water is very limited. The base case systems which were studied consisted of an MHD plant with a gas turbine bottoming plant, and required no cooling water. The gas turbine plant uses only air as its working fluid and receives its energy input from the MHD exhaust gases by means of metal tube heat exchangers. In addition to the base case systems, vapor cycle variation systems were considered which included the addition of a vapor cycle bottoming plant to improve the thermal efficiency. These systems required a small amount of cooling water. The MHD/gas turbine systems were modeled with sufficient detail, using realistic component specifications and costs, so that the thermal and economic performance of the system could be accurately determined. Three cases of MHD/gas turbine systems were studied, with Case I being similar to an MHD/steam system so that a direct comparison of the performances could be made, with Case II being representative of a second generation MHD system, and with Case III considering oxygen enrichment for early commercial applications. The systems are nominally 800 MW/sub e/ to 1000 MW/sub e/ in size. The results show that the MHD/gas turbine system has very good thermal and economic performances while requiring either little or no cooling water. Compared to the MHD/steam system which has a cooling tower heat load of 720 MW, the Base Case I MHD/gas turbine system has a heat rate which is 13% higher and a cost of electricity which is only 7% higher while requiring no cooling water. Case II results show that an improved performance can be expected from second generation MHD/gas turbine systems. Case III results show that an oxygen enriched MHD/gas turbine system may be attractive for early commercial applications in dry regions of the country.

  15. Adding Drift Kinetics to a Global MHD Code

    NASA Astrophysics Data System (ADS)

    Lyon, J.; Merkin, V. G.; Zhang, B.; Ouellette, J.

    2015-12-01

    Global MHD models have generally been successful in describing thebehavior of the magnetosphere at large and meso-scales. An exceptionis the inner magnetosphere where energy dependent particle drifts areessential in the dynamics and evolution of the ring current. Even inthe tail particle drifts are a significant perturbation on the MHDbehavior of the plasma. The most common drift addition to MHD has beeninclusion of the Hall term in Faraday's Law. There have been attemptsin the space physics context to include gradient and curvature driftswithin a single fluid MHD picture. These have not been terriblysuccessful because the use of a single, Maxwellian distribution doesnot capture the energy dependent nature of the drifts. The advent ofmulti-fluid MHD codes leads to a reconsideration of this problem. TheVlasov equation can be used to define individual ``species'' whichcover a specific energy range. Each fluid can then be treated ashaving a separate evolution. We take the approach of the RiceConvection Model (RCM) that each energy channel can be described by adistribution that is essentially isotropic in the guiding centerpicture. In the local picture, this gives rise to drifts that can bedescribed in terms of the energy dependent inertial and diamagneticdrifts. By extending the MHD equations with these drifts we can get asystem which reduces to the RCM approach in the slow-flow innermagnetosphere but is not restricted to cases where the flow speed issmall. The restriction is that the equations can be expanded in theratio of the Larmor radius to the gradient scale lengths. At scalesapproaching di, the assumption of gyrotropic (or isotropic)distributions break down. In addition to the drifts, the formalism canalso be used to include finite Larmor radius effects on the pressuretensor (gyro-viscosity). We present some initial calculations with this method.

  16. MHD Technology Transfer, Integration and Review Committee. Second semiannual status report, July 1988--March 1989

    SciTech Connect

    Not Available

    1989-10-01

    As part of the MHD Integrated Topping Cycle (ITC) project, TRW was given the responsibility to organize, charter and co-chair, with the Department of Energy (DOE), an MHD Technology Transfer, Integration and Review Committee (TTIRC). The Charter of the TTIRC, which was approved by the DOE in June 1988 and distributed to the committee members, is included as part of this Summary. As stated in the Charter, the purpose of this committee is to: (1) review all Proof-of-Concept (POC) projects and schedules in the national MHD program; to assess their compatibility with each other and the first commercial MHD retrofit plant; (2) establish and implement technology transfer formats for users of this technology; (3) identify interfaces, issues, and funding structures directly impacting the success of the commercial retrofit; (4) investigate and identify the manner in which, and by whom, the above should be resolved; and (5) investigate and assess other participation (foreign and domestic) in the US MHD Program. The DOE fiscal year 1989 MHD Program Plan Schedule is included at the end of this Summary. The MHD Technology Transfer, Integration and Review Committee`s activities to date have focused primarily on the ``technology transfer`` aspects of its charter. It has provided a forum for the dissemination of technical and programmatic information among workers in the field of MHD and to the potential end users, the utilities, by holding semi-annual meetings. The committee publishes this semi-annual report, which presents in Sections 2 through 11 capsule summaries of technical progress for all DOE Proof-of-Concept MHD contracts and major test facilities.

  17. Magnetotail dynamics: MHD simulations of driven and spontaneous dynamic changes

    SciTech Connect

    Birn, J.; Schindler, K.; Hesse, M.

    1994-05-01

    The dynamic evolution of the magnetotail during growth phase and expansion phase of a substorm is studied through threedimensional time-dependent MHD simulations. To model growth phase effects, an external electric field with an equatorward inflow is applied at the boundaries over a finite time period. This leads to the formation of a thin current sheet with greatly enhanced current density in the near tail, embedded in the wider plasma/current sheet, which becomes diminished in strength. A faster, spontaneous current sheet formation occurs when entropy conservation is released in an isobaric model, while the ideal MHD constraint persists. This may be a suitable model for the late, explosive part of the growth phase. The transition to the substorm expansive phase is modeled by an increase in anomalous resistivity, using either uniform resistivity or a current density dependent resistivity which is turned on when the current density exceeds a certain threshold. In both cases the violation of ideal MHD leads to resistive instability and the formation of a near-Earth neutral line, fast flow, and plasmoid ejection, together with the dipolarization and current reduction in the region further earthward. The spontaneous increase in total region 1 type field-aligned currents associated with the disruptions of the thin current sheets is less significant than that found in earlier simulations of the disruption of a wider current sheet, whereas the driven increase in the region 1 type current is substantial. The results demonstrate that the same dynamic process which appears spontaneous in the behavior of some quantities might be interpreted as entirely driven from the observation of others.

  18. MHD air heater development technology. Technical progress report, July 1-September 30, 1980

    SciTech Connect

    1980-11-01

    The technology development of the directly-fired high temperature air heater (HTAH) for MHD power plants is described. Progress is reported on the three tasks. The first task is materials selection, evaluation, and development. The objective of this task is to continue development of ceramic materials technology for the directly-fired HTAH. Task two is operability, performance, and materials testing. The objectives of this task are to demonstrate the technical feasibility of operating a directly-fired HTAH (including both the heater matrix and valves), to continue obtaining information on life and corrosion resistance of HTAH materials, and to obtain design information for full-scale studies and future design work. The objectives of the full-scale design task are to begin the identification of HTAH control requirements and control system needs, and to continue full-scale study efforts incorporating updated materials and design information in order to identify development needs for the HTAH development program. (WHK)

  19. Study of neoclassical tearing modes based on a reduced MHD model in cylindrical geometry

    NASA Astrophysics Data System (ADS)

    Sato, M.; Wakatani, M.

    2005-02-01

    Neoclassical tearing modes (NTMs) are examined with a reduced MHD model including the bootstrap current as a simple model, JBS vprop - dP/dr, in cylindrical tokamaks. It is found that linear instabilities due to the perturbation of bootstrap current appear for large JBS cases with large parallel thermal diffusivity, χpar, under small perpendicular thermal diffusivity, χbottom, in the pressure evolution equation. Here, other dissipations such as resistivity and viscosity are also finite. Although the linear growth rate of this unstable mode is small, the growth of magnetic energy of this unstable mode is usually accelerated after the saturation of kinetic energy. Its nonlinear behaviour shown by the evolution of magnetic islands is consistent with the standard nonlinear NTM theory.

  20. Observational Tests of Recent MHD Turbulence Perspectives

    NASA Astrophysics Data System (ADS)

    Ghosh, Sanjoy

    2001-06-01

    This grant seeks to analyze the Heliospheric Missions data to test current theories on the angular dependence (with respect to mean magnetic field direction) of magnetohydrodynamic (MHD) turbulence in the solar wind. Solar wind turbulence may be composed of two or more dynamically independent components. Such components include magnetic pressure-balanced structures, velocity shears, quasi-2D turbulence, and slab (Alfven) waves. We use a method, developed during the first two years of this grant, for extracting the individual reduced spectra of up to three separate turbulence components from a single spacecraft time series. The method has been used on ISEE-3 data, Pioneer Venus Orbiter, Ulysses, and Voyager data samples. The correlation of fluctuations as a function of angle between flow direction and magnetic-field direction is the focus of study during the third year.

  1. Observational Tests of Recent MHD Turbulence Perspectives

    NASA Technical Reports Server (NTRS)

    Ghosh, Sanjoy; Guhathakurta, M. (Technical Monitor)

    2001-01-01

    This grant seeks to analyze the Heliospheric Missions data to test current theories on the angular dependence (with respect to mean magnetic field direction) of magnetohydrodynamic (MHD) turbulence in the solar wind. Solar wind turbulence may be composed of two or more dynamically independent components. Such components include magnetic pressure-balanced structures, velocity shears, quasi-2D turbulence, and slab (Alfven) waves. We use a method, developed during the first two years of this grant, for extracting the individual reduced spectra of up to three separate turbulence components from a single spacecraft time series. The method has been used on ISEE-3 data, Pioneer Venus Orbiter, Ulysses, and Voyager data samples. The correlation of fluctuations as a function of angle between flow direction and magnetic-field direction is the focus of study during the third year.

  2. Ceramic component for MHD electrode

    DOEpatents

    Marchant, David D.; Bates, Junior L.

    1981-01-01

    A ceramic component which exhibits electrical conductivity down to near room temperatures has the formula: Hf.sub.x In.sub.y A.sub.z O.sub.2 where x=0.1 to 0.4, y=0.3 to 0.6, z=0.1 to 0.4 and A is a lanthanide rare earth or yttrium. The component is suitable for use in the fabrication of MHD electrodes or as the current leadout portion of a composite electrode with other ceramic components.

  3. Ceramic components for MHD electrode

    DOEpatents

    Marchant, D.D.

    A ceramic component which exhibits electrical conductivity down to near room temperatures has the formula: Hf/sub x/In/sub y/A/sub z/O/sub 2/ where x = 0.1 to 0.4, y = 0.3 to 0.6, z = 0.1 to 0.4 and A is a lanthanide rare earth or yttrium. The component is suitable for use in the fabrication of MHD electrodes or as the current leadout portion of a composite electrode with other ceramic components.

  4. MHD Integrated Topping Cycle Project

    SciTech Connect

    Not Available

    1992-07-01

    This eighteenth quarterly technical progress report of the MHD Integrated Topping cycle Project presents the accomplishments during the period November 1, 1991 to January 31, 1992. The precombustor is fully assembled. Manufacturing of all slagging stage components has been completed. All cooling panels were welded in place and the panel/shell gap was filled with RTV. Final combustor assembly is in progress. The low pressure cooling subsystem (LPCS) was delivered to the CDIF. Second stage brazing issues were resolved. The construction of the two anode power cabinets was completed.

  5. Numerical simulation of the operation of a MHD generator in transient regimes in MHD power stations

    SciTech Connect

    Bityurin, V.A.; Ivanov, P.P.; Koryagina, G.M.; Lyubimov, G.A.; Medin, S.A.; Morozov, G.N.; Prokop, A.S.

    1982-09-01

    Transient regimes of a MHD generator operating in combination with equipment in a MHD power station are analzyed with the help of a numerical model. The MHD generator, whose flow-through part consists of a nozzle, a channel, and a diffuser, is regulated by changing the flow rate and the load. Three types of MHD channels are studied: Faraday supersonic and subsonic, and diagonal supersonic. Their characteristics are presented and the efficiency of the MHD power station under nonrated regimes is determined. It is established that a MHD generator and the MHD power station as a whole admit quite efficient and deep regulation of the change in the flow rate of the working body.

  6. The Effect of Ivermectin in Seven Strains of Aedes aegypti (Diptera: Culicidae) Including a Genetically Diverse Laboratory Strain and Three Permethrin Resistant Strains

    PubMed Central

    Deus, K. M.; Saavedra-rodriguez, K.; Butters, M. P.; Black, W. C.; Foy, B. D.

    2014-01-01

    Seven different strains of Aedes aegypti (L.), including a genetically diverse laboratory strain, three laboratory-selected permethrin-resistant strains, a standard reference strain, and two recently colonized strains were fed on human blood containing various concentrations of ivermectin. Ivermectin reduced adult survival, fecundity, and hatch rate of eggs laid by ivermectin-treated adults in all seven strains. The LC50 of ivermectin for adults and the concentration that prevented 50% of eggs from hatching was calculated for all strains. Considerable variation in adult survival after an ivermectin-bloodmeal occurred among strains, and all three permethrin-resistant strains were significantly less susceptible to ivermectin than the standard reference strain. The hatch rate after an ivermectin bloodmeal was less variable among strains, and only one of the permethrin-resistant strains differed significantly from the standard reference strain. Our studies suggest that ivermectin induces adult mortality and decreases the hatch rate of eggs through different mechanisms. A correlation analysis of log-transformed LC50 among strains suggests that permethrin and ivermectin cross-resistance may occur. PMID:22493855

  7. Workshop on Feedback Stabilization of MHD Stabilities

    SciTech Connect

    McGuire, K.; Kugel, H.; La Haye, R.; Mauel, M.; Nevins, W.; Prager, S.

    1996-12-31

    The feedback stabilization of MHD instabilities is an area of research that is critical for improving the performance and economic attractiveness of magnetic confinement devices. A Workshop dedicated to feedback stabilization of MHD instabilities was held from December 11-13, 1996 at the Princeton Plasma Physics Laboratory, Princeton NJ, USA. The resulting presentations, conclusions, and recommendations are summarized.

  8. MHD (Magnetohydrodynamics) Program Plan, FY 1989

    NASA Astrophysics Data System (ADS)

    1989-05-01

    The essential elements of the current program, which is a continuation of the program outlined in the FY 1988 MHD Program Plan, are to: develop technical and environmental data for the integrated MHD topping cycle system through long-term (1000 hours) proof of concept (POC) testing; develop technical and environmental data for the integrated MHD bottoming cycle subsystem through long-term (4000 hours) POC testing; design and construct a seed regeneration system capable of independent operation, using spent seed materials from the MHD process; prepare a conceptual design for an MHD retrofit plant; and continue system studies and supporting research necessary for system testing. Results of the topping cycle POC tests at the Component Development and Integration Facility (CDIF), coupled with the bottoming cycle POC test results obtained at the Coal Fired Flow Facility (CFFF), and the seed regeneration POC effort will provide the critical engineering data base for the private sector's final decision on proceeding with the design, construction, and operation of an MHD retrofit. The development schedule, decision points, and resource requirements are discussed. As part of the MHD program, international activities of several nations are monitored and evaluated through contact with the international MHD scientific and technical community.

  9. Evidence of Active MHD Instability in EULAG-MHD Simulations of Solar Convection

    NASA Astrophysics Data System (ADS)

    Lawson, Nicolas; Strugarek, Antoine; Charbonneau, Paul

    2015-11-01

    We investigate the possible development of magnetohydrodynamical instabilities in the EULAG-MHD “millennium simulation” of Passos & Charbonneau. This simulation sustains a large-scale magnetic cycle characterized by solar-like polarity reversals taking place on a regular multidecadal cadence, and in which zonally oriented bands of strong magnetic fields accumulate below the convective layers, in response to turbulent pumping from above in successive magnetic half-cycles. Key aspects of this simulation include low numerical dissipation and a strongly sub-adiabatic fluid layer underlying the convectively unstable layers corresponding to the modeled solar convection zone. These properties are conducive to the growth and development of two-dimensional instabilities that are otherwise suppressed by stronger dissipation. We find evidence for the action of a non-axisymmetric magnetoshear instability operating in the upper portions of the stably stratified fluid layers. We also investigate the possibility that the Tayler instability may be contributing to the destabilization of the large-scale axisymmetric magnetic component at high latitudes. On the basis of our analyses, we propose a global dynamo scenario whereby the magnetic cycle is driven primarily by turbulent dynamo action in the convecting layers, but MHD instabilities accelerate the dissipation of the magnetic field pumped down into the overshoot and stable layers, thus perhaps significantly influencing the magnetic cycle period. Support for this scenario is found in the distinct global dynamo behaviors observed in an otherwise identical EULAG-MHD simulations, using a different degree of sub-adiabaticity in the stable fluid layers underlying the convection zone.

  10. Performance and flow characteristics of MHD seawater thruster

    SciTech Connect

    Doss, E.D.

    1990-01-01

    The main goal of the research is to investigate the effects of strong magnetic fields on the electrical and flow fields inside MHD thrusters. The results of this study is important in the assessment of the feasibility of MHD seawater propulsion for the Navy. To accomplish this goal a three-dimensional fluid flow computer model has been developed and applied to study the concept of MHD seawater propulsion. The effects of strong magnetic fields on the current and electric fields inside the MHD thruster and their interaction with the flow fields, particularly those in the boundary layers, have been investigated. The results of the three-dimensional computations indicate that the velocity profiles are flatter over the sidewalls of the thruster walls in comparison to the velocity profiles over the electrode walls. These nonuniformities in the flow fields give rise to nonuniform distribution of the skin friction along the walls of the thrusters, where higher values are predicted over the sidewalls relative to those over the electrode walls. Also, a parametric study has been performed using the three-dimensional MHD flow model to analyze the performance of continuous electrode seawater thrusters under different operating parameters. The effects of these parameters on the fluid flow characteristics, and on the thruster efficiency have been investigated. Those parameters include the magnetic field (10--20 T), thruster diameter, surface roughness, flow velocity, and the electric load factor. The results show also that the thruster performance improves with the strength of the magnetic field and thruster diameter, and the efficiency decreases with the flow velocity and surface roughness.

  11. Off-design performance analysis of MHD generator channels

    NASA Technical Reports Server (NTRS)

    Wilson, D. R.; Williams, T. S.

    1980-01-01

    A computer code for performing parametric design point calculations, and evaluating the off-design performance of MHD generators has been developed. The program is capable of analyzing Faraday, Hall, and DCW channels, including the effect of electrical shorting in the gas boundary layers and coal slag layers. Direct integration of the electrode voltage drops is included. The program can be run in either the design or off-design mode. Details of the computer code, together with results of a study of the design and off-design performance of the proposed ETF MHD generator are presented. Design point variations of pre-heat and stoichiometry were analyzed. The off-design study included variations in mass flow rate and oxygen enrichment.

  12. Control of linear modes in cylindrical resistive magnetohydrodynamics with a resistive wall, plasma rotation, and complex gain

    SciTech Connect

    Brennan, D. P.; Finn, J. M.

    2014-10-15

    Feedback stabilization of magnetohydrodynamic (MHD) modes in a tokamak is studied in a cylindrical model with a resistive wall, plasma resistivity, viscosity, and toroidal rotation. The control is based on a linear combination of the normal and tangential components of the magnetic field just inside the resistive wall. The feedback includes complex gain, for both the normal and for the tangential components, and it is known that the imaginary part of the feedback for the former is equivalent to plasma rotation [J. M. Finn and L. Chacon, Phys. Plasmas 11, 1866 (2004)]. The work includes (1) analysis with a reduced resistive MHD model for a tokamak with finite β and with stepfunction current density and pressure profiles, and (2) computations with a full compressible visco-resistive MHD model with smooth decreasing profiles of current density and pressure. The equilibria are stable for β = 0 and the marginal stability values β{sub rp,rw} < β{sub rp,iw} < β{sub ip,rw} < β{sub ip,iw} (resistive plasma, resistive wall; resistive plasma, ideal wall; ideal plasma, resistive wall; and ideal plasma, ideal wall) are computed for both models. The main results are: (a) imaginary gain with normal sensors or plasma rotation stabilizes below β{sub rp,iw} because rotation suppresses the diffusion of flux from the plasma out through the wall and, more surprisingly, (b) rotation or imaginary gain with normal sensors destabilizes above β{sub rp,iw} because it prevents the feedback flux from entering the plasma through the resistive wall to form a virtual wall. A method of using complex gain G{sub i} to optimize in the presence of rotation in this regime with β > β{sub rp,iw} is presented. The effect of imaginary gain with tangential sensors is more complicated but essentially destabilizes above and below β{sub rp,iw}.

  13. MHD Turbulence through the Heliosphere

    NASA Astrophysics Data System (ADS)

    Veltri, P.

    Velocity and magnetic field fluctuations in a wide range of space and time scales have been directly detected in the interplanetary medium In the solar corona the presence of MHD turbulence is naturally generated by the mechanical and magnetic energy input from the photosphere and it could be related to coronal heating as well as to energy release events like micro and nanoflares A certain amount of fluctuations from the solar corona arrives in the solar wind mainly as Alfvénic turbulence i e strongly correlated velocity and magnetic field fluctuations with a very low level of compressible density magnetic field intensity temperature fluctuations The whole system formed by the solar corona and the solar wind represents a sort of wind tunnel extremely useful to study the MHD turbulence properties The presence of magnetic turbulence in the heliosphere is identified as the source of charged particle collisionless diffusion which according the values of parameters like the energy level on magnetic fluctuations or the turbulence correlation length can display both a normal gaussian random walk and an anomalous subdiffusive or super diffusive behavior The former case is obtained in a situation of global stochasticity high level of fluctuation energy while the latter in a situation of weak chaos low level of fluctuation energy The talk will discuss turbulence generation at photospheric level its propagation and its interaction with heliospheric structures and its effects on anomalous transport processes of charged

  14. Feasibility of MHD submarine propulsion

    SciTech Connect

    Doss, E.D. ); Sikes, W.C. )

    1992-09-01

    This report describes the work performed during Phase 1 and Phase 2 of the collaborative research program established between Argonne National Laboratory (ANL) and Newport News Shipbuilding and Dry Dock Company (NNS). Phase I of the program focused on the development of computer models for Magnetohydrodynamic (MHD) propulsion. Phase 2 focused on the experimental validation of the thruster performance models and the identification, through testing, of any phenomena which may impact the attractiveness of this propulsion system for shipboard applications. The report discusses in detail the work performed in Phase 2 of the program. In Phase 2, a two Tesla test facility was designed, built, and operated. The facility test loop, its components, and their design are presented. The test matrix and its rationale are discussed. Representative experimental results of the test program are presented, and are compared to computer model predictions. In general, the results of the tests and their comparison with the predictions indicate that thephenomena affecting the performance of MHD seawater thrusters are well understood and can be accurately predicted with the developed thruster computer models.

  15. Cusp geometry in MHD simulations

    NASA Astrophysics Data System (ADS)

    Siscoe, George; Crooker, Nancy; Siebert, Keith; Maynard, Nelson; Weimer, Daniel; White, Willard

    2005-01-01

    The MHD simulations described here show that the latitude of the high-altitude cusp decreases as the IMF swings from North to South, that there is a pronounced dawn dusk asymmetry at high-altitude associated with a dawn dusk component of the IMF, and that at the same time there is also a pronounced dawn dusk asymmetry at low-altitude. The simulations generate a feature that represents what has been called the cleft. It appears as a tail (when the IMF has a By component) attached to the cusp, extending either toward the dawn flank or the dusk flank depending on the dawn dusk orientation of the IMF. This one-sided cleft connects the cusp to the magnetospheric sash. We compare cusp geometry predicted by MHD simulations against published observations based on Hawkeye and DMSP data. Regarding the high-altitude predictions, the comparisons are not definitive, mainly because the observations are incomplete or mutually inconsistent. Regarding the low-altitude prediction of a strong dawn dusk asymmetry, the observations are unambiguous and are in good qualitative agreement with the prediction.

  16. BCR-ABL kinase domain mutations, including 2 novel mutations in imatinib resistant Malaysian chronic myeloid leukemia patients-Frequency and clinical outcome.

    PubMed

    Elias, Marjanu Hikmah; Baba, Abdul Aziz; Azlan, Husin; Rosline, Hassan; Sim, Goh Ai; Padmini, Menon; Fadilah, S Abdul Wahid; Ankathil, Ravindran

    2014-04-01

    Discovery of imatinib mesylate (IM) as the targeted BCR-ABL protein tyrosine kinase inhibitor (TKI) has resulted in its use as the frontline therapy for chronic myeloid leukemia (CML) across the world. Although high response rates are observed in CML patients who receive IM treatment, a significant number of patients develop resistance to IM. Resistance to IM in patients has been associated with a heterogeneous array of mechanisms of which point mutations within the ABL tyrosine kinase domain (TKD) are the frequently documented. The types and frequencies of mutations reported in different population studies have shown wide variability. We screened 125 Malaysian CML patients on IM therapy who showed either TKI refractory or resistance to IM to investigate the frequency and pattern of BCR-ABL kinase domain mutations among Malaysian CML patients undergoing IM therapy and to determine the clinical significance. Mutational screening using denaturing high performance liquid chromatography (dHPLC) followed by DNA sequencing was performed on 125 IM resistant Malaysian CML patients. Mutations were detected in 28 patients (22.4%). Fifteen different types of mutations (T315I, E255K, G250E, M351T, F359C, G251E, Y253H, V289F, E355G, N368S, L387M, H369R, A397P, E355A, D276G), including 2 novel mutations were identified, with T315I as the predominant type of mutation. The data generated from clinical and molecular parameters studied were correlated with the survival of CML patients. Patients with Y253H, M351T and E355G TKD mutations showed poorer prognosis compared to those without mutation. Interestingly, when the prognostic impact of the observed mutations was compared inter-individually, E355G and Y253H mutations were associated with more adverse prognosis and shorter survival (P=0.025 and 0.005 respectively) than T315I mutation. Results suggest that apart from those mutations occurring in the three crucial regions (catalytic domain, P-loop and activation-loop), other rare

  17. Magnetohydrodynamics (MHD) Engineering Test Facility (ETF) 200 MWe power plant. Design Requirements Document (DRD)

    NASA Technical Reports Server (NTRS)

    Rigo, H. S.; Bercaw, R. W.; Burkhart, J. A.; Mroz, T. S.; Bents, D. J.; Hatch, A. M.

    1981-01-01

    A description and the design requirements for the 200 MWe (nominal) net output MHD Engineering Test Facility (ETF) Conceptual Design, are presented. Performance requirements for the plant are identified and process conditions are indicated at interface stations between the major systems comprising the plant. Also included are the description, functions, interfaces and requirements for each of these major systems. The lastest information (1980-1981) from the MHD technology program are integrated with elements of a conventional steam electric power generating plant.

  18. Verification Studies for Multi-Fluid Plasma Algorithms with Applications to Fast MHD Physics

    NASA Astrophysics Data System (ADS)

    Becker, Joe; Hakim, Ammar; Loverich, John; Stoltz, Peter

    2011-10-01

    In this paper we present a series of verification studies for finite volume algorithms in Nautilus, a numerical solver for fluid plasmas. Results include a set of typical Euler, Maxwell, MHD and Two-fluid benchmarks. In addition results and algorithms for a set of hyperbolic gauge cleaning schemes that can be applied to the MHD and Two-fluid systems using finite volume type methods will be presented. Finally we move onto applications in field reversed configuration (FRC) plasmas.

  19. Toward 3D MHD modeling of neoclassical tearing mode suppression by ECCD

    NASA Astrophysics Data System (ADS)

    Pratt, J.; Westerhof, E.

    2012-09-01

    We propose a framework to extend the magnetohydrodynamic (MHD) equations to include electron cyclotron current drive (ECCD) and discuss previous models proposed by Giruzzi et al. [2] and by Hegna and Callen [3]. To model neoclassical tearing mode (NTM) instabilities and study the growth of magnetic islands as NTMs evolve, we employ the nonlinear reduced-MHD simulation JOREK. We present tearing-mode growth-rate calculations from JOREK simulations.

  20. Closed cycle MHD power generation experiments in the NASA Lewis facility

    NASA Technical Reports Server (NTRS)

    Sovie, R. J.; Nichols, L. D.

    1974-01-01

    Discussion of the performance improvements achieved through some modifications made in the closed cycle MHD facility. These modifications include a redesign of the MHD duct interior, addition of mixing bars, increased electrical isolation, and experimentation with various cesium seed vaporization and injection techniques. Uniform Faraday and Hall voltage profiles were obtained, and the Faraday open circuit voltage varied from 90 to 100% of the ideal uBh.

  1. Prevalence and characterization of Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus, isolated from bulk tank milk from Minnesota dairy farms.

    PubMed

    Haran, K P; Godden, S M; Boxrud, D; Jawahir, S; Bender, J B; Sreevatsan, S

    2012-03-01

    Staphylococcus aureus is a common causative agent of bovine mastitis in dairy herds. The emergence of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals as well as the community is a significant and costly public health concern. S. aureus-related bovine mastitis is a common reason for therapeutic and/or prophylactic use of antibiotics on dairy farms. In this study, herd prevalence of S. aureus, including MRSA, was estimated from bulk tank milk (BTM) from Minnesota farms. A total of 150 pooled BTM samples from 50 farms, collected over 3 seasons (spring, summer, and fall of 2009), were assessed. Herd prevalence of methicillin-susceptible S. aureus (MSSA) was 84%, while MRSA herd prevalence was 4%. A total of 93 MSSA isolates and 2 MRSA isolates were recovered from 150 BTM samples. Antibiotic susceptibility testing of S. aureus isolates showed pansusceptibility in 54 isolates, resistance to a single antibiotic class in 21 isolates, resistance to two antibiotic classes in 13 isolates, and resistance to ≥3 antibiotics classes and thus multidrug resistance in 5 isolates. The two MRSA isolates displayed resistance to β-lactams, cephalosporins, and lincosamides and were multiresistant. Staphylococcal protein A gene (spa) typing identified spa types t529 and t034 most frequently among methicillin-susceptible isolates, while t121 was observed in MRSA isolates. Seven isolates, including the two MRSA isolates, produced staphylococcal enterotoxins B, C, D, and E on overnight culture. MRSA isolates were further genotyped using multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). Of the 2 MRSA isolates, one had a composite genotype profile of MLST ST 5-PFGE USA100-unknown spa type, which has been reported among hospital-associated MRSA isolates, while the second isolate carried the MLST ST 8-PFGE USA300-spa type t121 genotype, commonly identified among community-associated MRSA isolates. These results suggest that MRSA genotypes

  2. Technical support for open-cycle MHD program. Progress report, January-June 1979

    SciTech Connect

    Bomkamp, D. H.

    1980-07-01

    The support program for open-cycle MHD at the Argonne National Laboratory consists of developing the analytical tools needed for investigation of the performance of the major components in the combined-cycle MHD/steam power system. The analytical effort is centered on the primary components of the system that are unique to MHD and, also, on the integration of these analytical models into a model of the entire power-producing system. The present project activities include modeling of the combustor, generator, seed deposition, and formation and decomposition of NO. Parametric studies were performed to evaluate the performance of the U-25B generator and to support the design of the US U-25B generator. Refinements and improvements to the MHD systems code and executive program are described.

  3. Corrosion and arc erosion in MHD channels

    NASA Astrophysics Data System (ADS)

    Rosa, R. J.; Pollina, R. J.

    1991-04-01

    The objective of this task is to study the corrosion and arc erosion of MHD materials in a cooperative effort with, and to support, the MHD topping cycle program. Materials tested in the Avco Research Laboratory/Textron facility, or materials which have significant MHD importance, will be analyzed to document their physical deterioration. Conclusions shall be drawn about their wear mechanisms and lifetime in the MHD environment with respect to the following issues; sulfur corrosion, electrochemical corrosion, and arc erosion. The impact of any materials or slag conditions on the level of power output and on the level of leakage current in the MHD channel will also be noted, where appropriate. Two phenomena that can effect the analysis of slag leakage current have been investigated and found significant. These are: (1) transverse current along the slag layer in the insulator walls of an MHD duct, and (2) electrode surface voltage drops. Both tend to reduce the value inferred for average plasma conductivity and increase the value inferred for axial leakage current. These two effects in combination are potentially capable of explaining the high leakage inferred. Corrosion on the water side of metal MHD duct wall elements has been examined in CDIF and Mark 7 generators. It appears to be controllable by adjusting the pH of the water and/or by controlling the dissolved oxygen content.

  4. MHD generator with improved network coupling electrodes to a load

    DOEpatents

    Rosa, Richard J.

    1977-01-01

    An MHD generator has a plurality of segmented electrodes extending longitudinally of a duct, whereby progressively increasing high DC voltages are derived from a set of cathode electrodes and progressively increasing low DC voltages are derived from a set of anode electrodes. First and second load terminals are respectively connected to the cathode and anode electrodes by separate coupling networks, each of which includes a number of SCR's and a number of diode rectifiers.

  5. Efficacy of a combined oral formulation of derquantel-abamectin against the adult and larval stages of nematodes in sheep, including anthelmintic-resistant strains.

    PubMed

    Little, Peter R; Hodge, Andrew; Maeder, Steven J; Wirtherle, Nicole C; Nicholas, David R; Cox, George G; Conder, George A

    2011-09-27

    Derquantel (DQL), a semi-synthetic member of a novel anthelmintic class, the spiroindoles, in combination with abamectin (ABA) [as the combination product STARTECT(®)] is a new entry for the treatment and control of parasites in sheep. The 19 studies reported herein were conducted in Australia, New Zealand, South Africa and the United Kingdom to demonstrate the efficacy of derquantel-abamectin (DQL-ABA) against a broad spectrum of gastrointestinal and respiratory nematodes of sheep, and to support registration of the combination product. Eleven studies were conducted using natural or experimental parasite infections with unknown or unconfirmed resistance, while eight studies utilised isolates/strains with confirmed or well characterised resistance to one or more currently available anthelmintics, including macrocyclic lactones. All studies included DQL-ABA and negative control groups, and in selected studies one or more reference anthelmintic groups were included. In all studies the commercial formulation of DQL-ABA was administered orally at 2mg/kg DQL and 0.2mg/kg ABA; placebo was administered in the same volume as DQL-ABA; and reference anthelmintics were administered as per label recommendations, except in one instance where levamisole was administered at twice the label dose. Infection, necropsy, worm collection and worm counting procedures were performed using standard techniques. Efficacy was calculated based on the percentage reduction in geometric mean worm count relative to negative control for each nematode species and lifecycle stage targeted. Twenty-two isolates/strains used in the eight studies targeting resistant worms had proven resistance: three to one anthelmintic class, eleven to two classes and eight to three or more classes; of these resistant strains, 16 demonstrated resistance to a macrocyclic lactone anthelmintic. Regardless of resistance status in the 19 studies, DQL-ABA controlled a broad range of economically important gastrointestinal

  6. Application of Magnetohydrodynamics (MHD) and Recent Research Trend

    NASA Astrophysics Data System (ADS)

    Harada, Nobuhiro

    As the applications of Magnetohydrodynamic (MHD) energy conversion, research and development for high-efficiency and low emission electric power generation system, MHD accelerations and/or MHD thrusters, and flow control around hypersonic and re-entry vehicles are introduced. For closed cycle MHD power generation, high-efficiency MHD single system is the most hopeful system and space power system using mixed inert gas (MIG) working medium is proposed. For open cycle MHD, high-efficiency coal fired MHD system with CO2 recovery has been proposed. As inverse process of MHD power generation, MHD accelerators/thrusters are expected as the next generation propulsion system. Heat flux reduction to protect re-entry vehicles is expected by an MHD process for safety return from space missions.

  7. Alfven Wave Tomography for Cold MHD Plasmas

    SciTech Connect

    I.Y. Dodin; N.J. Fisch

    2001-09-07

    Alfven waves propagation in slightly nonuniform cold plasmas is studied by means of ideal magnetohydrodynamics (MHD) nonlinear equations. The evolution of the MHD spectrum is shown to be governed by a matrix linear differential equation with constant coefficients determined by the spectrum of quasi-static plasma density perturbations. The Alfven waves are shown not to affect the plasma density inhomogeneities, as they scatter off of them. The application of the MHD spectrum evolution equation to the inverse scattering problem allows tomographic measurements of the plasma density profile by scanning the plasma volume with Alfven radiation.

  8. Local structures of homogeneous Hall MHD turbulence

    NASA Astrophysics Data System (ADS)

    Miura, H.; Araki, K.

    2011-12-01

    Local structures of decaying homogeneous and isotropic Hall MHD turbulence are studied by means of direct numerical simulations. Regions of strong vorticity and strong current density in Hall MHD turbulence are compared to those of single-fluid MHD turbulence. An analysis by the use of a low-pass filter reveals that the introduction of the Hall term can modify not only small-scale structures of the current density but also structures of the vorticity field, especially at the scales smaller than the ion skin depth.

  9. SSX MHD plasma wind tunnel

    NASA Astrophysics Data System (ADS)

    Brown, Michael R.; Schaffner, David A.

    2015-06-01

    A new turbulent plasma source at the Swarthmore Spheromak Experiment (SSX) facility is described. The MHD wind tunnel configuration employs a magnetized plasma gun to inject high-beta plasma into a large, well-instrumented, vacuum drift region. This provides unique laboratory conditions approaching that in the solar wind: there is no applied background magnetic field in the drift region and has no net axial magnetic flux; the plasma flow speed is on the order of the local sound speed (M ~ 1), so flow energy density is comparable to thermal energy density; and the ratio of thermal to magnetic pressure is of order unity (plasma β ~ 1) so thermal energy density is also comparable to magnetic energy density. Results presented here and referenced within demonstrate the new capabilities and show how the new platform is proving useful for fundamental plasma turbulence studies.

  10. MHD seed recovery and regeneration

    NASA Astrophysics Data System (ADS)

    1988-10-01

    The TRW Econoseed MHD Seed Regeneration Process is based on the reaction of calcium formate with potassium sulfate spent seed from an MHD electric power generation plant. The process was tested at bench scale, design a proof of concept (POC) test plant, plan and cost a Phase 2 project for a POC plant evaluation and prepare a conceptual design of a 300 MW (t) commercial plant. The results of the project are as follows: (1) each of the unit operations is demonstrated, and (2) the data are incorporated into a POC plant design and project cost, as well as a 300 MW (t) commercial retrofit plant design and cost estimate. Specific results are as follows: (1) calcium formate can be produced at 100 percent yield in a total retention time of less than 5 minutes, (2) utilizing the calcium formate, spent seed can quantitatively be converted to potassium formate, potassium carbonate or mixtures of these with potassium sulfate as per the commercial design without measurable loss of potassium to insolubles at a total retention time under 20 minutes and ambient pressure, (3) the solid rejects form the process meet RCRA EP Toxicity requirements for safe disposal, and (4) filtration and evaporation data, as well as reaction data cited above, show that the Econoseed technology is ready for scale up to POC plant scale. Economics forecast studies show that the total cost per unit of potassium for seed regeneration by the Econoseed Process is in the range of $0.23 to $0.27/lb, a cost which is less than half the potassium cost of $0.63/lb for purchasing new potassium carbonate.

  11. Distribution of temperature in the slot of an induction MHD pump

    NASA Astrophysics Data System (ADS)

    Krishbergs, R.

    2007-09-01

    At thermal calculations of the induction MHD machines, the mean temperatures of main parts of the machine are often defined. Yet, with the increase of specific electromagnetic loads, with the use of new heat-resistant insulating materials and with the intention to use electrically short windings (a small number of poles that causes asymmetry of phase currents) in the pumps of mean power determining are the local temperature peaks in the winding, though the winding mean temperature is far from limiting. The paper considers the temperature distribution over the slot height in the induction MHD pump. Figs 2, Refs 13.

  12. Decreasing population selection rates of resistance mutation K65R over time in HIV-1 patients receiving combination therapy including tenofovir

    PubMed Central

    Theys, K.; Snoeck, J.; Vercauteren, J.; Abecasis, A. B.; Vandamme, A.-M.; Camacho, R. J.

    2013-01-01

    Objectives The use of tenofovir is highly associated with the emergence of mutation K65R, which confers broad resistance to nucleoside/nucleotide analogue reverse transcriptase inhibitors (NRTIs), especially when tenofovir is combined with other NRTIs also selecting for K65R. Although recent HIV-1 treatment guidelines discouraging these combinations resulted in reduced K65R selection with tenofovir, updated information on the impact of currently recommended regimens on the population selection rate of K65R is presently lacking. Methods In this study, we evaluated changes over time in the selection rate of resistance mutation K65R in a large population of 2736 HIV-1-infected patients failing combination antiretroviral treatment between 2002 and 2010. Results The K65R resistance mutation was detected in 144 patients, a prevalence of 5.3%. A large majority of observed K65R cases were explained by the use of tenofovir, reflecting its wide use in clinical practice. However, changing patterns over time in NRTIs accompanying tenofovir resulted in a persistent decreasing probability of K65R selection by tenofovir-based therapy. The currently recommended NRTI combination tenofovir/emtricitabine was associated with a low probability of K65R emergence. For any given dual NRTI combination including tenofovir, higher selection rates of K65R were consistently observed with a non-nucleoside reverse transcriptase inhibitor than with a protease inhibitor as the third agent. Discussion Our finding of a stable time trend of K65R despite elevated use of tenofovir illustrates increased potency of current HIV-1 therapy including tenofovir. PMID:23027713

  13. Novel Treatment for Mantle Cell Lymphoma including Therapy-resistant Tumor by NF-κB and mTOR Dual Targeting Approach

    PubMed Central

    Chaturvedi, Nagendra K.; Rajule, Rajkumar N.; Shukla, Ashima; Radhakrishnan, Prakash; Todd, Gordon L.; Natarajan, Amarnath; Vose, Julie M.; Joshi, Shantaram S.

    2014-01-01

    Mantle cell lymphoma (MCL) is one of the most aggressive B cell non-Hodgkin lymphomas with a median survival of about five years. Currently, there is no curative therapy available for refractory MCL because of relapse from therapy-resistant tumor cells. The NF-κB and mTOR pathways are constitutively active in refractory MCL leading to increased proliferation and survival. Targeting these pathways is an ideal strategy to improve therapy for refractory MCL. Therefore, we investigated the in vitro and in vivo antilymphoma activity and associated molecular mechanism of action of a novel compound 13-197, a quinoxaline analog that specifically perturbs IκB kinase (IKK) β, a key regulator of the NF-κB pathway. 13-197 decreased the proliferation and induced apoptosis in MCL cells including therapy-resistant cells compared to control cells. Furthermore, we observed down-regulation of IκBα phosphorylation and inhibition of NF-κB nuclear translocation by 13-197 in MCL cells. In addition, NF-κB regulated genes such as cyclin D1, Bcl-XL and Mcl-1 were down-regulated in 13-197-treated cells. 13-197 also inhibited the phosphorylation of S6K and 4E-BP1, the downstream molecules of mTOR pathway that are also activated in refractory MCL. Further, 13-197 reduced the tumor burden in vivo in the kidney, liver, and lungs of therapy-resistant MCL bearing NOD-SCID mice compared to vehicle treated mice; indeed, 13-197 significantly increased the survival of MCL transplanted mice. Together, results suggest that 13-197 as a single agent disrupts the NF-κB and mTOR pathways leading suppression of proliferation and increased apoptosis in malignant MCL cells including reduction in tumor burden in mice. PMID:23963361

  14. MHD simulation of RF current drive in MST

    SciTech Connect

    Hendries, E. R.; Anderson, J. K.; Forest, C. B.; Reusch, J. A.; Seltzman, A. H.; Sovinec, C. R.; Diem, S.; Harvey, R. W.

    2014-02-12

    Auxiliary heating and current drive using RF waves such as the electron Bernstein wave (EBW) promises to advance the performance of the reversed field pinch (RFP). In previous computational work [1], a hypothetical edge-localized current drive is shown to suppress the tearing activity which governs the macroscopic transport properties of the RFP. The ideal conditions for tearing stabilization include a reduced toroidal induction, and precise width and radial position of the Gaussian-shaped external current drive. In support of the EBW experiment on the Madison Symmetric Torus, an integrated modeling scheme now incorporates ray tracing and Fokker-Plank predictions of auxiliary current into single fluid MHD. Simulations at low Lundquist number (S ∼ 10{sup 4}) generally agree with the previous work; significantly more burdensome simulations at MST-like Lundquist number (S ∼ 3×10{sup 6}) show unexpected results. The effect on nonlinearly saturated current profile by a particular RF-driven external force decreases in magnitude and widens considerably as the Lundquist number increases toward experimental values. Simulations reproduce the periodic current profile relaxation events observed in experiment (sawteeth) in the absence of current profile control. Reduction of the tearing mode amplitudes is still observable; however, reduction is limited to periods between the large bursts of magnetic activity at each sawtooth. The sawtoothing pattern persists with up to 10 MW of externally applied RF power. Periods with prolonged low tearing amplitude are predicted with a combination of external current drive and a reduced toroidal loop voltage, consistent with previous conclusions. Finally, the resistivity profile is observed to have a strong effect on the optimal externally driven current profile for mode stabilization.

  15. Suspected nosocomial infections with multi-drug resistant E. coli, including extended-spectrum beta-lactamase (ESBL)-producing strains, in an equine clinic.

    PubMed

    Walther, Birgit; Lübke-Becker, Antina; Stamm, Ivonne; Gehlen, Heidrun; Barton, Ann Kristin; Janssen, Traute; Wieler, Lothar H; Guenther, Sebastian

    2014-01-01

    Enterobacteriaceae such as Escherichia coli are common commensals as well as opportunistic and obligate pathogens. They cause a broad spectrum of infectious diseases in various hosts, including hospital-associated infections. In recent years, the rise of extended spectrum beta-lactamase (ESBL)-producing E. coli in companion animals (dogs, cats and horses) has been striking. However, reports on nosocomial infections are mostly anecdotic. Here we report on the suspected nosocomial spread of both ESBL-producing and non-ESBL-producing multi-drug resistant E. coli isolates in three equine patients within an equine clinic. Unlike easy-to-clean hospitalization opportunities available for small animal settings like boxes and cages made of ceramic floor tiles or stainless steel, clinical settings for horses are challenging environments for infection control programs due to unavoidable extraneous material including at least hay and materials used for horse bedding. The development of practice-orientated recommendations is needed to improve the possibilities for infection control to prevent nosocomial infections with multi-drug resistant and other transmissible pathogens in equine clinical settings. PMID:25872251

  16. Multidimensional MHD Simulations Of DSA Using AstroBEAR

    NASA Astrophysics Data System (ADS)

    Edmon, Paul; Jones, T.; Mitran, S.; Cunningham, A.; Frank, A.

    2009-05-01

    We present a modification to the AstroBEAR (Astronomical Boundary Embedded Adaptive Refinement) MHD code (Cunningham et. al. 2007) that allows it to treat time dependent Diffusive Shock Acceleration (DSA) of cosmic rays in multiple dimensions including dynamical feedback from the cosmic rays. Utilizing the power of Adaptive Mesh Refinement (AMR) in tandem with efficient methods for cosmic ray diffusion and advection, this allows us for the first time to explore the evolution of modified MHD shocks in more than one spatial dimension. Among the early applications of the code will be investigations of colliding and clumpy stellar winds, type II supernova remnants and cosmic ray driven instabilities. This work is supported at the University of Minnesota by NSF, NASA and the Minnesota Supercomputing Institute.

  17. Linear MHD Stability Analysis of the SSPX Spheromak

    NASA Astrophysics Data System (ADS)

    Jayakumar, R.; Cohen, B. I.; Hooper, E. B.; Lodestro, L. L.; McLean, H. S.; Pearlstein, L. D.; Wood, R.; Turnbull, A. D.; Sovinec, C.

    2007-11-01

    Good correlation between the toroidal mode numbers of measured magnetic fluctuations in high temperature SSPX plasmas and presence of low-order rational surfaces in the reconstructed q profiles, suggests that the quality of magnetic surfaces in SSPX is sufficiently good for applying standard linear MHD stability analyses. Previously we have reported on benchmarking the code NIMROD against GATO, with good agreement in growth rates for ideal-MHD internal kinks and an external kinks with no current on open field lines (for equilibria imported from the code Corsica). Recent stability analyses also show that presence of low order rational surfaces causes internal modes to become unstable. We will report on the progress in applying these tools for assessing beta limits in SSPX, using NIMROD analyses including current on open field lines and for comparison with experiments.

  18. 3D simulation studies of tokamak plasmas using MHD and extended-MHD models

    SciTech Connect

    Park, W.; Chang, Z.; Fredrickson, E.; Fu, G.Y.

    1996-12-31

    The M3D (Multi-level 3D) tokamak simulation project aims at the simulation of tokamak plasmas using a multi-level tokamak code package. Several current applications using MHD and Extended-MHD models are presented; high-{beta} disruption studies in reversed shear plasmas using the MHD level MH3D code, {omega}{sub *i} stabilization and nonlinear island saturation of TAE mode using the hybrid particle/MHD level MH3D-K code, and unstructured mesh MH3D{sup ++} code studies. In particular, three internal mode disruption mechanisms are identified from simulation results which agree which agree well with experimental data.

  19. Towards an MHD Theory for the Standoff Distance of Earth's Bow Shock

    NASA Technical Reports Server (NTRS)

    Carins, Iver H.; Grabbe, Crockett L.

    1994-01-01

    A magnetohydrodynamic (MHD) theory is developed for the standoff distance a(s) of the bow shock and the thickness Delta(ms) of the magnetosheath, using the empirical Spreiter et al. relation Delta(ms) = kX and the MHD density ratio X across the shock. The theory includes as special cases the well-known gasdynamic theory and associated phenomenological MHD-like models for Delta(ms) and As. In general, however, MHD effects produce major differences from previous models, especially at low Alfev (Ma) and Sonic (Ms) Mach numbers. The magnetic field orientation Ma, Ms and the ratio of specific heats gamma are all important variables of the theory. In contrast, the fast mode Mach number need play no direct role. Three principle conclusions are reached. First the gasdynamic and phenomenological models miss important dependences of field orientation and Ms generally provide poor approximations to the MHD results. Second, changes in field orientation and Ms are predicted to cause factor of approximately 4 changes in Delta(ms) at low Ma. These effects should be important when predicting the shock's location or calculating gramma from observations. Third, using Spreiter et al.'s value for k in the MHD theory leads to maxima a(s) values at low Ma and nominal Ms that are much smaller than observations and MHD simulations require. Resolving this problem requires either the modified Spreiter-like relation and larger k found in recent MHD simulations and/or a breakdown in the Spreiter-like relation at very low Ma.

  20. Towards an MHD theory for the standoff distance of Earth's bow shock

    NASA Technical Reports Server (NTRS)

    Cairns, Iver H.; Grabbe, Crockett L.

    1994-01-01

    An MHD theory is developed for the stand-off distance a(sub s) of the bow shock and the thickness delta(sub ms) of the magnetosheath, using the empirical Spreiter et al. relation delta(sub ms) = kX and the MHD density ratio X across the shock. The theory includes as special cases the well-known gasdynamic theory and associated phenomenological MHD-like models for delta(sub ms) and a(sub s). In general, however, MHD effects produce major differences from previous models, especially at low Alfven (M(sub A)) and sonic (M(sub S)) Mach numbers. The magnetic field orientation, M(sub A), M(sub S) and the ratio of specific heats gamma are all important variables of the theory. Three principal conclusions are reached. First, the gasdynamic and phenomenological models miss important dependances on field orientation and M(sub S) and generally provide poor approximations to the MHD results. Second, changes in field orientation and M(sub S) are predicted to cause factor of approximately 4 changes in delta(sub ms) at low M(sub A). Third, using Spreiter et al.'s value for k in the MHD theory leads to maximum a(sub s) values at low M(sub A) and nominal M(sub S) that are much smaller than observations and MHD simulations require. Resolving this problem requires either the modified Spreiter-like relation and larger k found in recent MHD simulations and/or breakdown in the Spreiter-like relation at very low M(sub A).

  1. [Nonlinear magnetohydrodynamics]. [Threshold unstable MHD activity

    SciTech Connect

    Not Available

    1992-01-01

    Theoretical predictions were compared with available data from JET on the threshold unstable MHD activity in toroidal confinement devices. In particular, questions arising as to Hartmans number and the selection of a kinematic viscosity are discussed.

  2. Activity of Debio1452, a FabI Inhibitor with Potent Activity against Staphylococcus aureus and Coagulase-Negative Staphylococcus spp., Including Multidrug-Resistant Strains

    PubMed Central

    Rhomberg, Paul R.; Kaplan, Nachum; Jones, Ronald N.; Farrell, David J.

    2015-01-01

    Staphylococcus aureus and coagulase-negative staphylococci (CoNS) are responsible for a wide variety of human infections. The investigational antibacterial Debio1450 (previously AFN-1720), a prodrug of Debio1452 (previously AFN-1252), specifically targets staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 inhibits FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. The activity of Debio1452 against CoNS, methicillin-susceptible S. aureus (MSSA), and methicillin-resistant S. aureus (MRSA), including significant clones, was determined. A globally diverse collection of 574 patient isolates from 35 countries was tested that included CoNS (6 species, 103 strains), MSSA (154 strains), MRSA (163 strains), and molecularly characterized strains (including spa-typed MRSA clones; 154 strains). The isolates were tested for susceptibility by CLSI broth microdilution methods against Debio1452 and 10 comparators. The susceptibility rates for the comparators were determined using CLSI and EUCAST breakpoint criteria. All S. aureus and CoNS strains were inhibited by Debio1452 concentrations of ≤0.12 and ≤0.5 μg/ml, respectively. The MIC50s for MSSA, MRSA, and molecularly characterized MRSA strains were 0.004 μg/ml, and the MIC90s ranged from 0.008 to 0.03 μg/ml. The MICs were higher for the CoNS isolates (MIC50/90, 0.015/0.12 μg/ml). Among S. aureus strains, resistance was common for erythromycin (61.6%), levofloxacin (49.0%), clindamycin (27.6%), tetracycline (15.7%), and trimethoprim-sulfamethoxazole (7.0%). Debio1452 demonstrated potent activity against MSSA, MRSA, and CoNS. Debio1452 showed significantly greater activity overall (MIC50, 0.004 μg/ml) than the other agents tested against these staphylococcal species, which included dominant MRSA clones and strains resistant to currently utilized antimicrobial agents. PMID:25691627

  3. Solar driven liquid metal MHD power generator

    NASA Astrophysics Data System (ADS)

    Lee, J. H.; Hohl, F.

    1983-06-01

    A solar energy collector focuses solar energy onto a solar oven which is attached to a mixer which in turn is attached to the channel of a MHD generator. Gas enters the oven and a liquid metal enters the mixer. The gas/liquid metal mixture is heated by the collected solar energy and moves through the MHD generator thereby generating electrical power. The mixture is then separated and recycled.

  4. Solar driven liquid metal MHD power generator

    NASA Technical Reports Server (NTRS)

    Lee, J. H.; Hohl, F. (Inventor)

    1983-01-01

    A solar energy collector focuses solar energy onto a solar oven which is attached to a mixer which in turn is attached to the channel of a MHD generator. Gas enters the oven and a liquid metal enters the mixer. The gas/liquid metal mixture is heated by the collected solar energy and moves through the MHD generator thereby generating electrical power. The mixture is then separated and recycled.

  5. US/USSR cooperative program in open-cycle MHD electrical power generation. Joint test report no. 4. Tests in the U-25B facility MHD generator tests No. 6 and 7

    NASA Astrophysics Data System (ADS)

    Picologlou, B. F.; Batenin, V. M.

    1981-01-01

    The MHD generator was operated at its design parameters. New plasma diagnostic devices are described and include: a traversing dual electrical probe for determining distribution of electron concentrations, a traversing probe that includes a pitot tube for measuring total and static pressure, and a light detector for measuring plasma luminescence. Data are presented on heat flux distribution along the channel, the forest data of this type obtained for an MHD facility of such size. Results are given of experimental studies of plasma characteristics, gasdynamic, thermal, and electrical MHD channel performance, and temporal and spatial nonuniformities.

  6. Results from the Pamir-3U pulsed portable MHD power system program

    SciTech Connect

    Swallom, D.W.; Goldfarb, V.M.; Gibbs, J.S.

    1996-12-31

    The Pamir-3U MHD Power System Acceptance Test Program was successfully performed in the United States in 1995. The Pamir-3U MHD system is a portable power system that can be transported to various operational locations. The power system is self-contained and does not require extensive support equipment to generate the design power. The work was performed by the IVTAN-Association of the Russian Academy of Sciences (Russia) and Textron Systems Division (US). Major subcontractors that participated in this effort are Nizhny Novgorod Machine Building Plant (Russia), Federal Center of Dual Technologies Soyuz (Russia) and Aerojet Corporation (US). A preliminary acceptance test program, consisting of five power tests and several preliminary tests, was conducted during August 1994 at Geodesiya Research and Development Institute, Krasnoarmejsk, Russia. During this test program, power levels as high as 15 MW(e) were obtained. Operation of the facility in various operating modes was demonstrated, and several tests were conducted where the resistance was varied during the hot-fire test run. For the final Pamir-3U MHD Power System Acceptance Test Program, eight hot-fire tests were performed. The performance levels of the Pamir-3U MHD Power System were confirmed during these tests. As a result of the experiments performed, the operational ability of the Pamir-3U MHD power system to operate in a variety of performance modes and under a variety of operating conditions was confirmed.

  7. MHD technology transfer, integration, and review committee

    NASA Astrophysics Data System (ADS)

    1990-05-01

    As part of Task 8 of the magnetohydrodynamic (MHD) Integrated Topping Cycle (ITC) project, TRW was given the responsibility to organize, charter and co-chair, with the Department of Energy (DOE), an MHD Technology Transfer, Integration and Review Committee (TTIRC). The TTIRC consists of an Executive Committee (EC) which acts as the governing body, and a General Committee (GC), also referred to as the main or full committee, consisting of representatives from the various POC contractors, participating universities and national laboratories, utilities, equipment suppliers, and other potential MHD users or investors. The purpose of the TTIRC is to: (1) review all Proof-of-Concept (POC) projects and schedules in the national MHD program; to assess their compatibility with each other and the first commercial MHD retrofit plant; (2) establish and implement technology transfer formats for users of this technology; (3) identify interfaces, issues, and funding structures directly impacting the success of the commercial retrofit; (4) investigate and identify the manner in which, and by whom, the above should be resolved; and (5) investigate and assess other participation (foreign and domestic) in the U.S. MHD Program. There are seven sections: introduction; Executive Committee and General Committee activity; Committee activities related to technology transfer; ongoing POC integration activities being performed under the auspices of the Executive Committee; recommendations passed on to the DOE by the Executive Committee; Planned activities for the next six months.

  8. Gonorrhoea and gonococcal antimicrobial resistance surveillance networks in the WHO European Region, including the independent countries of the former Soviet Union.

    PubMed

    Unemo, Magnus; Ison, Catherine A; Cole, Michelle; Spiteri, Gianfranco; van de Laar, Marita; Khotenashvili, Lali

    2013-12-01

    Antimicrobial resistance (AMR) in Neisseria gonorrhoeae has emerged for essentially all antimicrobials following their introduction into clinical practice. During the latest decade, susceptibility to the last remaining options for antimicrobial monotherapy, the extended-spectrum cephalosporins (ESC), has markedly decreased internationally and treatment failures with these ESCs have been verified. In response to this developing situation, WHO and the European Centre for Disease Prevention and Control (ECDC) have published global and region-specific response plans, respectively. One main component of these action/response plans is to enhance the surveillance of AMR and treatment failures. This paper describes the perspectives from the diverse WHO European Region (53 countries), including the independent countries of the former Soviet Union, regarding gonococcal AMR surveillance networks. The WHO European Region has a high prevalence of resistance to all previously recommended antimicrobials, and most of the first strictly verified treatment failures with cefixime and ceftriaxone were also reported from Europe. In the European Union/European Economic Area (EU/EEA), the European gonococcal antimicrobial surveillance programme (Euro-GASP) funded by the ECDC is running. In 2011, the Euro-GASP included 21/31 (68%) EU/EEA countries, and the programme is further strengthened annually. However, in the non-EU/EEA countries, internationally reported and quality assured gonococcal AMR data are lacking in 87% of the countries and, worryingly, appropriate support for establishment of a GASP is still lacking. Accordingly, national and international support, including political and financial commitment, for gonococcal AMR surveillance in the non-EU/EEA countries of the WHO European Region is essential. PMID:24243879

  9. Newtonian and Non-Newtonian Magnetic-field Relaxations in Solar-coronal MHD

    NASA Astrophysics Data System (ADS)

    Low, B. C.

    2013-05-01

    This paper treats the relaxation of a magnetic field into a minimum-energy force-free state in a cold (pressure-less) viscous fluid, under the frozen-in condition of perfect electrical conductivity and letting the viscosity-dissipated energy be completely lost. A non-Newtonian fluid in popular use is studied in relation to the Newtonian viscous fluid, as two alternative numerical means to (1) construct force-free fields representing solar coronal structures in realistic geometry and (2) investigate the Parker theory of spontaneous formation of electric current sheets as a basic MHD process. Faraday's induction equation imposes an independent condition on the fluid velocity at rigid, perfectly conducting boundaries. This boundary condition is quite compatible with Newtonian mechanics but not with the non-Newtonian fluid model where velocity is equated to the Lorentz force with a free, positive multiplicative-factor. This defining property gives rise to unphysical or artificial singularities not previously known that are completely distinct from the physically admissible singularities representing the current sheets of the Parker theory. In particular, the non-Newtonian fluid takes a magnetic field with neutral points from any one of a continuum of initial states into an unphysical state instead of the proper force-free end-state accessible by Newtonian relaxation. The validity of previously published MHD results based on this non-Newtonian fluid, including some counterclaims against the Parker theory, is dubious. Investigating the Parker theory requires numerical relaxation models capable of anticipating and accurately describing inevitable current-sheet singularities. By including a weak resistivity to dissipate the inevitable current sheets as they form, the field can change topology intermittently to seek a terminal force-free state free of singularities. The minimum-energy state of this more complete model corresponds to the long-lived relaxed structures in the

  10. NEWTONIAN AND NON-NEWTONIAN MAGNETIC-FIELD RELAXATIONS IN SOLAR-CORONAL MHD

    SciTech Connect

    Low, B. C.

    2013-05-01

    This paper treats the relaxation of a magnetic field into a minimum-energy force-free state in a cold (pressure-less) viscous fluid, under the frozen-in condition of perfect electrical conductivity and letting the viscosity-dissipated energy be completely lost. A non-Newtonian fluid in popular use is studied in relation to the Newtonian viscous fluid, as two alternative numerical means to (1) construct force-free fields representing solar coronal structures in realistic geometry and (2) investigate the Parker theory of spontaneous formation of electric current sheets as a basic MHD process. Faraday's induction equation imposes an independent condition on the fluid velocity at rigid, perfectly conducting boundaries. This boundary condition is quite compatible with Newtonian mechanics but not with the non-Newtonian fluid model where velocity is equated to the Lorentz force with a free, positive multiplicative-factor. This defining property gives rise to unphysical or artificial singularities not previously known that are completely distinct from the physically admissible singularities representing the current sheets of the Parker theory. In particular, the non-Newtonian fluid takes a magnetic field with neutral points from any one of a continuum of initial states into an unphysical state instead of the proper force-free end-state accessible by Newtonian relaxation. The validity of previously published MHD results based on this non-Newtonian fluid, including some counterclaims against the Parker theory, is dubious. Investigating the Parker theory requires numerical relaxation models capable of anticipating and accurately describing inevitable current-sheet singularities. By including a weak resistivity to dissipate the inevitable current sheets as they form, the field can change topology intermittently to seek a terminal force-free state free of singularities. The minimum-energy state of this more complete model corresponds to the long-lived relaxed structures in the

  11. 17th Workshop on MHD Stability Control: addressing the disruption challenge for ITER

    NASA Astrophysics Data System (ADS)

    Buttery, Richard

    2013-08-01

    This annual workshop on magnetohydrodynamic stability control was held on 5-7 November 2012 at Columbia University in the city of New York, in the aftermath of a violent hydrodynamic instability event termed 'Hurricane Sandy'. Despite these challenging circumstances, Columbia University managed an excellent meeting, enabling the full participation of the community. This Workshop has been held since 1996 to help in the development of understanding and control of magnetohydrodynamic (MHD) instabilities for future fusion reactors. It covers a wide range of stability topics—from disruptions, to tearing modes, error fields, edge-localized modes (ELMs), resistive wall modes (RWMs) and ideal MHD—spanning many device types (tokamaks, stellarators and reversed field pinches) to identify commonalities in the physics and a means of control. The theme for 2012 was 'addressing the disruption challenge for ITER', and thus the first day had a heavy focus on both the avoidance and mitigation of disruptions in ITER. Key elements included understanding how to apply 3D fields to maintain stability, as well as managing the disruption process itself through mitigating loads in the thermal quench and handling so called 'runaway electrons'. This culminated in a panel discussion on the disruption mitigation strategy for ITER, which noted that heat load asymmetries during the thermal quench appear to be an artifact of MHD processes, and that runaway electron generation may be inevitable, suggesting research should focus on control and dissipation of the runaway beam. The workshop was combined this year with the annual US-Japan MHD Workshop, with a special section looking more deeply at 'Fundamentals of 3D Perturbed Equilibrium Control', with interesting sessions on 3D equilibrium reconstruction, RWM physics, novel control concepts such as non-magnetic sensing, adaptive control, q < 2 tokamak operation, and the effects of flow. The final day turned to tearing mode interactions

  12. The Role of GONG observations in Global MHD Modeling

    NASA Astrophysics Data System (ADS)

    Linker, Jon; Downs, Cooper; Lionello, Roberto; Caplan, Ronald M.; Riley, Pete; Mikić, Zoran; Arge, Nick; Henney, Carl

    2015-04-01

    The solar magnetic field is an essential aspect of any predictive model of the solar corona. For many years, the magnetic field has been measured most reliably in the photosphere. So-called ``synoptic'' maps of the photospheric field (actually built up from magnetograms acquired over the course of the solar rotation) are or have been available from a number of ground- and space-based observatories, including the Global Oscillation Network Group (GONG). MHD models of the solar corona have typically used these maps to develop boundary conditions. GONG data is unique among the ground-based observatories in (1) providing magnetogams at a high-cadence (2) providing 24 hour coverage and (3) supplying helioseismic data that can be used to provide estimates of new active regions that have emerged on the far side of the Sun. These three elements are especially important as MHD models attempt to address the time-dependent nature of the corona. In this talk we describe how the combination of flux transport models driven by GONG data, along with estimates of far side active region emergence, can be used in coronal MHD modeling and the advantages gained from this approach. Work supported by AFOSR, NASA, and NSF.

  13. Parametric analysis of closed cycle magnetohydrodynamic (MHD) power plants

    NASA Technical Reports Server (NTRS)

    Owens, W.; Berg, R.; Murthy, R.; Patten, J.

    1981-01-01

    A parametric analysis of closed cycle MHD power plants was performed which studied the technical feasibility, associated capital cost, and cost of electricity for the direct combustion of coal or coal derived fuel. Three reference plants, differing primarily in the method of coal conversion utilized, were defined. Reference Plant 1 used direct coal fired combustion while Reference Plants 2 and 3 employed on site integrated gasifiers. Reference Plant 2 used a pressurized gasifier while Reference Plant 3 used a ""state of the art' atmospheric gasifier. Thirty plant configurations were considered by using parametric variations from the Reference Plants. Parametric variations include the type of coal (Montana Rosebud or Illinois No. 6), clean up systems (hot or cold gas clean up), on or two stage atmospheric or pressurized direct fired coal combustors, and six different gasifier systems. Plant sizes ranged from 100 to 1000 MWe. Overall plant performance was calculated using two methodologies. In one task, the channel performance was assumed and the MHD topping cycle efficiencies were based on the assumed values. A second task involved rigorous calculations of channel performance (enthalpy extraction, isentropic efficiency and generator output) that verified the original (task one) assumptions. Closed cycle MHD capital costs were estimated for the task one plants; task two cost estimates were made for the channel and magnet only.

  14. MHD magnet technology development program summary, September 1982

    SciTech Connect

    Not Available

    1983-11-01

    The program of MHD magnet technology development conducted for the US Department of Energy by the Massachusetts Institute of Technology during the past five years is summarized. The general strategy is explained, the various parts of the program are described and the results are discussed. Subjects covered include component analysis, research and development aimed at improving the technology base, preparation of reference designs for commercial-scale magnets with associated design evaluations, manufacturability studies and cost estimations, the detail design and procurement of MHD test facility magnets involving transfer of technology to industry, investigations of accessory subsystem characteristics and magnet-flow-train interfacing considerations and the establishment of tentative recommendations for design standards, quality assurance procedures and safety procedures. A systematic approach (framework) developed to aid in the selection of the most suitable commercial-scale magnet designs is presented and the program status as of September 1982 is reported. Recommendations are made for future work needed to complete the design evaluation and selection process and to provide a sound technological base for the detail design and construction of commercial-scale MHD magnets. 85 references.

  15. An unsplit Godunov method for ideal MHD via constrained transport

    NASA Astrophysics Data System (ADS)

    Gardiner, Thomas A.; Stone, James M.

    2005-05-01

    We describe a single step, second-order accurate Godunov scheme for ideal MHD based on combining the piecewise parabolic method (PPM) for performing spatial reconstruction, the corner transport upwind (CTU) method of Colella for multidimensional integration, and the constrained transport (CT) algorithm for preserving the divergence-free constraint on the magnetic field. We adopt the most compact form of CT, which requires the field be represented by area-averages at cell faces. We demonstrate that the fluxes of the area-averaged field used by CT can be made consistent with the fluxes of the volume-averaged field returned by a Riemann solver if they obey certain simple relationships. We use these relationships to derive new algorithms for constructing the CT fluxes at grid cell corners which reduce exactly to the equivalent one-dimensional solver for plane-parallel, grid-aligned flow. We show that the PPM reconstruction algorithm must include multidimensional terms for MHD, and we describe a number of important extensions that must be made to CTU in order for it to be used for MHD with CT. We present the results of a variety of test problems to demonstrate the method is accurate and robust.

  16. Integron, Plasmid and Host Strain Characteristics of Escherichia coli from Humans and Food Included in the Norwegian Antimicrobial Resistance Monitoring Programs

    PubMed Central

    Sunde, Marianne; Simonsen, Gunnar Skov; Slettemeås, Jannice Schau; Böckerman, Inger; Norström, Madelaine

    2015-01-01

    Antimicrobial resistant Escherichia coli (n=331) isolates from humans with bloodstream infections were investigated for the presence of class 1 and class 2 integrons. The integron cassettes arrays were characterized and the findings were compared with data from similar investigations on resistant E. coli from meat and meat products (n=241) produced during the same time period. All isolates were obtained from the Norwegian monitoring programs for antimicrobial resistance in human pathogens and in the veterinary sector. Methods used included PCR, sequencing, conjugation experiments, plasmid replicon typing and subtyping, pulsed-field-gel-electrophoresis and serotyping. Integrons of class 1 and 2 occurred significantly more frequently among human isolates; 45.4% (95% CI: 39.9-50.9) than among isolates from meat; 18% (95% CI: 13.2 -23.3), (p<0.01, Chi-square test). Identical cassette arrays including dfrA1-aadA1, aadA1, dfrA12-orfF-aadA2, oxa-30-aadA1 (class 1 integrons) and dfrA1-sat1-aadA1 (class 2 integrons) were detected from both humans and meat. However, the most prevalent cassette array in human isolates, dfrA17-aadA5, did not occur in isolates from meat, suggesting a possible linkage between this class 1 integron and a subpopulation of E. coli adapted to a human host. The drfA1-aadA1 and aadA1 class 1 integrons were found frequently in both human and meat isolates. These isolates were subjected to further studies to investigate similarities with regard to transferability, plasmid and host strain characteristics. We detected incF plasmids with pMLST profile F24:A-:B1 carrying drfA1-aadA1 integrons in isolates from pork and in a more distantly related E. coli strain from a human with septicaemia. Furthermore, we showed that most of the class 1 integrons with aadA1 were located on incF plasmids with pMLST profile F51:A-:B10 in human isolates. The plasmid was present in unrelated as well as closely related host strains, demonstrating that dissemination of this

  17. Genotypic and Antimicrobial Susceptibility of Carbapenem-resistant Acinetobacter baumannii: Analysis of ISAba Elements and blaOXA-23-like Genes Including a New Variant

    PubMed Central

    Bahador, Abbas; Raoofian, Reza; Pourakbari, Babak; Taheri, Mohammad; Hashemizadeh, Zahra; Hashemi, Farhad B.

    2015-01-01

    Carbapenem-resistant Acinetobacter baumannii (CR-AB) causes serious nosocomial infections, especially in ICU wards of hospitals, worldwide. Expression of blaOXA genes is the chief mechanism of conferring carbapenem resistance among CR-AB. Although some blaOXA genes have been studied among CR-AB isolates from Iran, their blaOXA-23-like genes have not been investigated. We used a multiplex-PCR to detect Ambler class A, B, and D carbapenemases of 85 isolates, and determined that 34 harbored blaOXA-23-like genes. Amplified fragment length polymorphism (AFLP) genotyping, followed by DNA sequencing of blaOXA-23-like amplicons of CR-AB from each AFLP group was used to characterize their blaOXA-23-like genes. We also assessed the antimicrobial susceptibility pattern of CR-AB isolates, and tested whether they harbored insertion sequences ISAba1 and ISAba4. Sequence comparison with reference strain A. baumannii (NCTC12156) revealed five types of mutations in blaOXA-23-like genes; including one novel variant and four mutants that were already reported from China and the USA. All of the blaOXA-23-like genes mutations were associated with increased minimum inhibitory concentrations (MICs) against imipenem. ISAba1 and ISAba4 sequences were detected upstream of blaOXA-23 genes in 19 and 7% of isolates, respectively. The isolation of CR-AB with new blaOXA-23 mutations including some that have been reported from the USA and China highlights CR-AB pervasive distribution, which underscores the importance of concerted national and global efforts to control the spread of CR-AB isolates worldwide. PMID:26617588

  18. Relative timing of substorm features in MHD simulations

    NASA Technical Reports Server (NTRS)

    Hesse, Michael; Birn, Joachim

    1992-01-01

    An investigation of the temporal sequence of substorm phenomena based on three dimensional MHD (magnetohydrodynamic) simulations of magnetic reconnection and plasmoid formation is presented. The investigation utilizes a spatially localized resistivity model which leads to a significantly faster evolution than found in previous investigations. The analysis of the results concentrates on substorm features that have received considerable attention in the past. The formation of magnetic neutral lines, the occurrence of fast flows directed both earthward and tailward, and the magnetic field changes leading to the formation of the substorm current wedge, and to the depolarization of the magnetic field earthward of the reconnection region and its dependence on the spatial distribution of resistivity, are discussed. These phenomena are seen as an integral part of the nonlinear evolution of the three dimensional tearing instability.

  19. "Ideal" tearing and the transition to fast reconnection in the weakly collisional MHD and EMHD regimes

    NASA Astrophysics Data System (ADS)

    Del Sarto, Daniele; Pucci, Fulvia; Tenerani, Anna; Velli, Marco

    2016-03-01

    This paper discusses the transition to fast growth of the tearing instability in thin current sheets in the collisionless limit where electron inertia drives the reconnection process. It has been previously suggested that in resistive MHD there is a natural maximum aspect ratio (ratio of sheet length and breadth to thickness) which may be reached for current sheets with a macroscopic length L, the limit being provided by the fact that the tearing mode growth time becomes of the same order as the Alfvén time calculated on the macroscopic scale. For current sheets with a smaller aspect ratio than critical the normalized growth rate tends to zero with increasing Lundquist number S, while for current sheets with an aspect ratio greater than critical the growth rate diverges with S. Here we carry out a similar analysis but with electron inertia as the term violating magnetic flux conservation: previously found scalings of critical current sheet aspect ratios with the Lundquist number are generalized to include the dependence on the ratio de2/L2, where de is the electron skin depth, and it is shown that there are limiting scalings which, as in the resistive case, result in reconnecting modes growing on ideal time scales. Finite Larmor radius effects are then included, and the rescaling argument at the basis of "ideal" reconnection is proposed to explain secondary fast reconnection regimes naturally appearing in numerical simulations of current sheet evolution.

  20. MHD waveguides in space plasma

    SciTech Connect

    Mazur, N. G.; Fedorov, E. N.; Pilipenko, V. A.

    2010-07-15

    The waveguide properties of two characteristic formations in the Earth's magnetotail-the plasma sheet and the current (neutral) sheet-are considered. The question of how the domains of existence of different types of MHD waveguide modes (fast and slow, body and surface) in the (k, {omega}) plane and their dispersion properties depend on the waveguide parameters is studied. Investigation of the dispersion relation in a number of particular (limiting) cases makes it possible to obtain a fairly complete qualitative pattern of all the branches of the dispersion curve. Accounting for the finite size of perturbations across the wave propagation direction reveals new additional effects such as a change in the critical waveguide frequencies, the excitation of longitudinal current at the boundaries of the sheets, and a change in the symmetry of the fundamental mode. Knowledge of the waveguide properties of the plasma and current sheets can explain the occurrence of preferred frequencies in the low-frequency fluctuation spectra in the magnetotail. In satellite observations, the type of waveguide mode can be determined from the spectral properties, as well as from the phase relationships between plasma oscillations and magnetic field oscillations that are presented in this paper.

  1. MHD Integrated Topping Cycle Project

    SciTech Connect

    Not Available

    1992-02-01

    This fourteenth quarterly technical progress report of the MHD Integrated Topping Cycle Project presents the accomplishments during the period November 1, 1990 to January 31, 1991. Testing of the High Pressure Cooling Subsystem electrical isolator was completed. The PEEK material successfully passed the high temperature, high pressure duration tests (50 hours). The Combustion Subsystem drawings were CADAM released. The procurement process is in progress. An equipment specification and RFP were prepared for the new Low Pressure Cooling System (LPCS) and released for quotation. Work has been conducted on confirmation tests leading to final gas-side designs and studies to assist in channel fabrication.The final cathode gas-side design and the proposed gas-side designs of the anode and sidewall are presented. Anode confirmation tests and related analyses of anode wear mechanisms used in the selection of the proposed anode design are presented. Sidewall confirmation tests, which were used to select the proposed gas-side design, were conducted. The design for the full scale CDIF system was completed. A test program was initiated to investigate the practicality of using Avco current controls for current consolidation in the power takeoff (PTO) regions and to determine the cause of past current consolidation failures. Another important activity was the installation of 1A4-style coupons in the 1A1 channel. A description of the coupons and their location with 1A1 channel is presented herein.

  2. Basic Bell-MHD turbulence

    SciTech Connect

    Beresnyak, Andrey; Li, Hui

    2014-06-20

    Nonresonant current instability was identified by Bell as an important mechanism for magnetic field amplification in supernova remnants. In this paper we focus on studying the nonlinear stage of this instability using the incompressible MHD formulation. We demonstrate that the evolution of magnetic turbulence driven by the Bell instability resembles turbulence driven on large scales. More importantly, we demonstrate that the energy-containing scale for magnetic fields is proportional to the square root of the magnetic energy density. Given the observational constraints of the possible field amplification, this new relation allows us to directly estimate the maximum energy of particles scattered by such fields, and this estimate is normally below the average particle energy. This implies that, without taking into account the feedback to cosmic rays (CRs), the typical scales of Bell fields, in either the linear or nonlinear regime, will be too small to affect high-energy particle acceleration. We mention several scenarios of back reaction to CRs that could be important.

  3. Study of nonlinear MHD equations governing the wave propagation in twisted coronal loops

    NASA Technical Reports Server (NTRS)

    Parhi, S.; DeBruyne, P.; Goossens, M.; Zhelyazkov, I.

    1995-01-01

    The solar corona, modelled by a low beta, resistive plasma slab, sustains MHD wave propagations due to shearing footpoint motions in the photosphere. By using a numerical algorithm the excitation and nonlinear development of MHD waves in twisted coronal loops are studied. The plasma responds to the footpoint motion by sausage waves if there is no twist. The twist in the magnetic field of the loop destroys initially developed sausage-like wave modes and they become kinks. The transition from sausage to kink modes is analyzed. The twist brings about mode degradation producing high harmonics and this generates more complex fine structures. This can be attributed to several local extrema in the perturbed velocity profiles. The Alfven wave produces remnants of the ideal 1/x singularity both for zero and non-zero twist and this pseudo-singularity becomes less pronounced for larger twist. The effect of nonlinearity is clearly observed by changing the amplitude of the driver by one order of magnitude. The magnetosonic waves also exhibit smoothed remnants of ideal logarithmic singularities when the frequency of the driver is correctly chosen. This pseudo-singularity for fast waves is absent when the coronal loop does not undergo any twist but becomes pronounced when twist is included. On the contrary, it is observed for slow waves even if there is no twist. Increasing the twist leads to a higher heating rate of the loop. The larger twist shifts somewhat uniformly distributed heating to layers inside the slab corresponding to peaks in the magnetic field strength.

  4. Ideal MHD properties for proposed noncircular tokamaks

    SciTech Connect

    Helton, F.J.; Greene, J.M.

    1986-10-01

    We obtain Double Dee, TFXC-C, Big Dee, and JET equlibria which are optimized with respect to both shape and current profile for stability to ideal MHD modes. With a wall reasonably far from the plasma surface we find that the external kink constrains q/sub 1/ to be above two, where q/sub 1/ is the plasma surface value of the safety factor, and the ballooning mode limits the value of ..beta... Then a relevant stable ..beta.. value for the Double Dee reactor design is over 7%. Such a Double Dee equilibrium is not in a separated second stability region and thus does not have a problem with accessibility. A relevant stable ..beta.. value for the TFCX-C reactor design is over 6%. Equivalent relevant stable ..beta.. values for the Big Dee (17%) and JET (7%) are included for calibration purposes. We compare these relevant stable ..beta.. values with the ..beta..'s determined by two recent scaling laws.

  5. MHD Instability and Turbulence in the Tachocline

    NASA Technical Reports Server (NTRS)

    Werne, Joe; Wagner, William J. (Technical Monitor)

    2003-01-01

    The focus of this project was to study the physical processes that govern tachocline dynamics and structure. Specific features explored included stratification, shear, waves, and toroidal and poloidal background fields. In order to address recent theoretical work on anisotropic mixing and dynamics in the tachocline, we were particularly interested in such anisotropic mixing for the specific tachocline processes studied. Transition to turbulence often shapes the largest-scale features that appear spontaneously in a flow during the development of turbulence. The resulting large-scale straining field can control the subsequent dynamics; therefore, anticipation of the large-scale straining field that results for individual realizations of the transition to turbulence can be important for subsequent dynamics, flow morphology, and transport characteristics. As a result, we paid particular attention to the development of turbulence in the stratified and sheared environment of the tachocline. This is complicated by the fact that the linearly stability of sheared MHD flows is non-self-adjoint, implying that normal asymptotic linear stability theory may not be relevant.

  6. Initial Studies of Validation of MHD Models for MST Reversed Field Pinch Plasmas

    NASA Astrophysics Data System (ADS)

    Jacobson, C. M.; Almagri, A. F.; Craig, D.; McCollam, K. J.; Reusch, J. A.; Sauppe, J. P.; Sovinec, C. R.; Triana, J. C.

    2015-11-01

    Quantitative validation of visco-resistive MHD models for RFP plasmas takes advantage of MST's advanced diagnostics. These plasmas are largely governed by MHD relaxation activity, so that a broad range of validation metrics can be evaluated. Previous nonlinear simulations using the visco-resistive MHD code DEBS at Lundquist number S = 4 ×106 produced equilibrium relaxation cycles in qualitative agreement with experiment, but magnetic fluctuation amplitudes b~ were at least twice as large as in experiment. The extended-MHD code NIMROD previously suggested that a two-fluid model may be necessary to produce b~ in agreement with experiment. For best comparisons with DEBS and to keep computational expense tractable, NIMROD is run in single-fluid mode at low S. These simulations are complemented by DEBS at higher S in cylindrical geometry, which will be used to examine b~ as a function of S. Experimental measurements are used with results from these simulations to evaluate validation metrics. Convergence tests of previous high S DEBS simulations are also discussed, along with benchmarking of DEBS and NIMROD with the SPECYL and PIXIE3D codes. Work supported by U.S. DOE and NSF.

  7. A stochastic approach to uncertainty in the equations of MHD kinematics

    NASA Astrophysics Data System (ADS)

    Phillips, Edward G.; Elman, Howard C.

    2015-03-01

    The magnetohydrodynamic (MHD) kinematics model describes the electromagnetic behavior of an electrically conducting fluid when its hydrodynamic properties are assumed to be known. In particular, the MHD kinematics equations can be used to simulate the magnetic field induced by a given velocity field. While prescribing the velocity field leads to a simpler model than the fully coupled MHD system, this may introduce some epistemic uncertainty into the model. If the velocity of a physical system is not known with certainty, the magnetic field obtained from the model may not be reflective of the magnetic field seen in experiments. Additionally, uncertainty in physical parameters such as the magnetic resistivity may affect the reliability of predictions obtained from this model. By modeling the velocity and the resistivity as random variables in the MHD kinematics model, we seek to quantify the effects of uncertainty in these fields on the induced magnetic field. We develop stochastic expressions for these quantities and investigate their impact within a finite element discretization of the kinematics equations. We obtain mean and variance data through Monte Carlo simulation for several test problems. Toward this end, we develop and test an efficient block preconditioner for the linear systems arising from the discretized equations.

  8. MHD simulations of supernova driven ISM turbulence

    NASA Astrophysics Data System (ADS)

    Gressel, Oliver; Ziegler, Udo

    The dynamic evolution of the (stratified) turbulent interstellar medium (ISM) is simulated utilizing a three-dimensional MHD model including various physical effects. The computational domain covers a box of 0.5x0.5x2.0 kpc at a resolution of typically 128x128x1024 grid cells. The model includes (constant kinematic) viscosity and magnetic diffusivity. The adiabatic equation of state is supplemented by a parameterized heating- and cooling-function allowing for thermal instability (TI). The update due to heating and cooling is implemented implicitly using a Patankar-type discretization. Turbulence is driven by supernova explosions which are modelled as local injections of thermal energy, smeared over three standard-deviations of a Gaussian support with FWHM of 20pc. Supernova rates are adopted for typical cited values. Within our model we make a distinction between Type I and Type II SNe. Latter are statistically clustered by the (artificial) constraint that the density at the explosion site be above average (with respect to a horizontal slab) - former are spatially uncorrelated. The dual-energy feature of the conservative NIRVANA-code is used to tackle the extreme ratio of kinetic to internal energy that arises from the violent energy input. We stress the importance of using a conservative scheme to properly transfer the injected energy to kinetic motion. The model also includes a differentially rotating background (with shearing boundary conditions in radial direction) as well as vertical stratification. The initial density and pressure profiles are in hydrostatic equilibrium with respect to the equation of state given by the radiative equilibrium. Including z-dependent heating rates this leads to a considerable deviation from usual isothermal initial models. The primary focus of this work is on the galactic dynamo and the generation of large-scale magnetic fields. As a secondary target we are also interested in general properties of the ISM that are of importance

  9. Dipole Alignment in Rotating MHD Turbulence

    NASA Technical Reports Server (NTRS)

    Shebalin, John V.; Fu, Terry; Morin, Lee

    2012-01-01

    We present numerical results from long-term CPU and GPU simulations of rotating, homogeneous, magnetohydrodynamic (MHD) turbulence, and discuss their connection to the spherically bounded case. We compare our numerical results with a statistical theory of geodynamo action that has evolved from the absolute equilibrium ensemble theory of ideal MHD turbulence, which is based on the ideal MHD invariants are energy, cross helicity and magnetic helicity. However, for rotating MHD turbulence, the cross helicity is no longer an exact invariant, although rms cross helicity becomes quasistationary during an ideal MHD simulation. This and the anisotropy imposed by rotation suggests an ansatz in which an effective, nonzero value of cross helicity is assigned to axisymmetric modes and zero cross helicity to non-axisymmetric modes. This hybrid statistics predicts a large-scale quasistationary magnetic field due to broken ergodicity , as well as dipole vector alignment with the rotation axis, both of which are observed numerically. We find that only a relatively small value of effective cross helicity leads to the prediction of a dipole moment vector that is closely aligned (less than 10 degrees) with the rotation axis. We also discuss the effect of initial conditions, dissipation and grid size on the numerical simulations and statistical theory.

  10. Corrosion and arc erosion in MHD channels

    NASA Astrophysics Data System (ADS)

    Rosa, R. J.; Pollina, R. J.

    1990-07-01

    The objective of this task is to study the corrosion and arc erosion of MHD materials in a cooperative effort with, and to support, the MHD topping cycle program. Materials tested in the Avco Research Laboratory/Textron facility, or materials which have significant MHD importance, will be analyzed to document their physical deterioration. Conclusions shall be drawn about their wear mechanisms and lifetime in the MHD environment with respect to the following issues; sulfur corrosion, electrochemical corrosion, and arc erosion. The impact of any materials or slag conditions on the level of power output and on the level of leakage current in the MHD channel will also be noted, where appropriate. The work performed to date in the analysis of channel gas side materials has served to identify and clarify the respective environments to which the various materials are subjected and identified a performance ranking of materials. For high voltage intercathode gaps, which show the most severe wear, the materials rank in the order from best to worst: W, Mo, 90WCu, 97W2Fe1Ni, 75WCu, and Cr. We have shown data which indicates that lifetime is sensitive to gap voltage. Therefore for conditions under which iron oxide addition maintains low voltage intercathode gaps 75WCu becomes an excellent cathode material.