Science.gov

Sample records for including subcritical cases

  1. Integrated modeling of CO2 storage and leakage scenarios including transitions between super- and sub-critical conditions, and phase change between liquid and gaseous CO2

    SciTech Connect

    Pruess, K.

    2011-05-15

    Storage of CO{sub 2} in saline aquifers is intended to be at supercritical pressure and temperature conditions, but CO{sub 2} leaking from a geologic storage reservoir and migrating toward the land surface (through faults, fractures, or improperly abandoned wells) would reach subcritical conditions at depths shallower than 500-750 m. At these and shallower depths, subcritical CO{sub 2} can form two-phase mixtures of liquid and gaseous CO{sub 2}, with significant latent heat effects during boiling and condensation. Additional strongly non-isothermal effects can arise from decompression of gas-like subcritical CO{sub 2}, the so-called Joule-Thomson effect. Integrated modeling of CO{sub 2} storage and leakage requires the ability to model non-isothermal flows of brine and CO{sub 2} at conditions that range from supercritical to subcritical, including three-phase flow of aqueous phase, and both liquid and gaseous CO{sub 2}. In this paper, we describe and demonstrate comprehensive simulation capabilities that can cope with all possible phase conditions in brine-CO{sub 2} systems. Our model formulation includes: (1) an accurate description of thermophysical properties of aqueous and CO{sub 2}-rich phases as functions of temperature, pressure, salinity and CO{sub 2} content, including the mutual dissolution of CO{sub 2} and H{sub 2}O; (2) transitions between super- and subcritical conditions, including phase change between liquid and gaseous CO{sub 2}; (3) one-, two-, and three-phase flow of brine-CO{sub 2} mixtures, including heat flow; (4) non-isothermal effects associated with phase change, mutual dissolution of CO{sub 2} and water, and (de-) compression effects; and (5) the effects of dissolved NaCl, and the possibility of precipitating solid halite, with associated porosity and permeability change. Applications to specific leakage scenarios demonstrate that the peculiar thermophysical properties of CO{sub 2} provide a potential for positive as well as negative

  2. Accelerator driven sub-critical core

    DOEpatents

    McIntyre, Peter M; Sattarov, Akhdiyor

    2015-03-17

    Systems and methods for operating an accelerator driven sub-critical core. In one embodiment, a fission power generator includes a sub-critical core and a plurality of proton beam generators. Each of the proton beam generators is configured to concurrently provide a proton beam into a different area of the sub-critical core. Each proton beam scatters neutrons within the sub-critical core. The plurality of proton beam generators provides aggregate power to the sub-critical core, via the proton beams, to scatter neutrons sufficient to initiate fission in the sub-critical core.

  3. Pachydermodactyly: A Case Report Including Histopathology.

    PubMed

    Rancy, Schneider K; Granstein, Richard D; Bansal, Manjula; Barley, Christopher L; Fields, Theodore R; Wolfe, Scott W

    2016-08-01

    Pachydermodactyly (PDD) is a rare form of digital fibromatosis characterized by painless soft tissue swelling, primarily about the proximal interphalangeal joints. The skin at the metacarpophalangeal joints, the palm, and the dorsum of the hand may also be involved. Because swelling can occur over the proximal interphalangeal and metacarpophalangeal joints, PDD may be confused with juvenile inflammatory arthropathy and may even occur concurrently. We present the clinical and histopathologic findings of a case of PDD characterized by bilateral proximal phalangeal involvement of the index through little fingers. PMID:27180953

  4. Radical abdominoplasty, including body shaping: representative cases.

    PubMed

    Mühlbauer, W

    1989-01-01

    Even in the age of liposuction there exist certain situations for which abdominoplasty in its radical form is indicated--for example, redundant skin after radical weight loss, the stigmata of postpregnancy syndrome, and localized accumulation of adipose tissue--the lipodystrophies and resistant generalized obesity. Redundant skin after radical weight loss is resected simultaneously around the abdomen, the lumbar regions, the perineum, and the thighs. The typical stigmata of postpregnancy syndrome may be excised through an extended abdominoplasty combined with simultaneous excision and pexy of the inner aspects of the thighs leaving a "bikini" scar behind. A mastopexy may be added. Genetically predisposed localized lipodystrophies in the abdominal lumbar, and upper thigh region may be resected through a circular abdominoplasty with or without simultaneous resection of the perineum and inner thighs. Abdominal aprons often contain umbilical or ventral hernias that may need to be repaired simultaneously. Representative cases are presented and dangers and complications are discussed. PMID:2741749

  5. ECO2M: A TOUGH2 Fluid Property Module for Mixtures of Water, NaCl, and CO2, Including Super- and Sub-Critical Conditions, and Phase Change Between Liquid and Gaseous CO2

    SciTech Connect

    Pruess, K.

    2011-04-01

    ECO2M is a fluid property module for the TOUGH2 simulator (Version 2.0) that was designed for applications to geologic storage of CO{sub 2} in saline aquifers. It includes a comprehensive description of the thermodynamics and thermophysical properties of H{sub 2}O - NaCl - CO{sub 2} mixtures, that reproduces fluid properties largely within experimental error for temperature, pressure and salinity conditions in the range of 10 C {le} T {le} 110 C, P {le} 600 bar, and salinity from zero up to full halite saturation. The fluid property correlations used in ECO2M are identical to the earlier ECO2N fluid property package, but whereas ECO2N could represent only a single CO{sub 2}-rich phase, ECO2M can describe all possible phase conditions for brine-CO{sub 2} mixtures, including transitions between super- and sub-critical conditions, and phase change between liquid and gaseous CO{sub 2}. This allows for seamless modeling of CO{sub 2} storage and leakage. Flow processes can be modeled isothermally or non-isothermally, and phase conditions represented may include a single (aqueous or CO{sub 2}-rich) phase, as well as two-and three-phase mixtures of aqueous, liquid CO{sub 2} and gaseous CO{sub 2} phases. Fluid phases may appear or disappear in the course of a simulation, and solid salt may precipitate or dissolve. TOUGH2/ECO2M is upwardly compatible with ECO2N and accepts ECO2N-style inputs. This report gives technical specifications of ECO2M and includes instructions for preparing input data. Code applications are illustrated by means of several sample problems, including problems that had been previously solved with TOUGH2/ECO2N.

  6. ITEP subcritical neutron generator driven by charged particle accelerator

    SciTech Connect

    Shvedov, Oleg V.; Chuvilo, Ivan V.; Kulikov, Evgeny V.; Vasiliev, Valery V.; Igumnov, Mikhail M.; Kozodaev, Alexander M.; Volkov, Evgeny B.; Lopatkin, Alexander V.

    1995-09-15

    A research facility prototype including a combination of a linear accelerator, a neutron generating target, a subcritical multiplying system is discussed. Principles of the nuclear safety ensuring and means of its attainment for Subcritical Neutron Generator are considered. The scheme of the multiplying is shown. The assembly will be mounted in the body of the partly dismantled ITEP HWR. Requirements for subcritical assembly are worked out and their feasibility within the framework of the heavy-water blanket is shown. The facility's application as a full-scale model of more powerful installations of this kind and for fundamental experimental research has been investigated.

  7. Subcritical crack growth in marble

    NASA Astrophysics Data System (ADS)

    Nara, Yoshitaka; Nishida, Yuki; Toshinori, Ii; Harui, Tomoki; Tanaka, Mayu; Kashiwaya, Koki

    2016-04-01

    It is essential to study time-dependent deformation and fracturing in various rock materials to prevent natural hazards related to the failure of a rock mass. In addition, information of time-dependent fracturing is essential to ensure the long-term stability of a rock mass surrounding various structures. Subcritical crack growth is one of the main causes of time-dependent fracturing in rock. It is known that subcritical crack growth is influenced by not only stress but also surrounding environment. Studies of subcritical crack growth have been widely conducted for silicate rocks such as igneous rocks and sandstones. By contrast, information of subcritical crack growth in carbonate rocks is not enough. Specifically, influence of surrounding environment on subcritical crack growth in carbonate rock should be clarified to ensure the long-term stability of a rock mass. In this study, subcritical crack growth in marble was investigated. Especially, the influence of the temperature, relative humidity and water on subcritical crack growth in marble is investigated. As rock samples, marbles obtained in Skopje-City in Macedonia and Carrara-City in Italy were used. To measure subcritical crack growth, we used the load relaxation method of the double-torsion (DT) test. All measurements by DT test were conducted under controlled temperature and relative humidity. For both marbles, it was shown that the crack velocity in marble in air increased with increasing relative humidity at a constant temperature. Additionally, the crack velocity in water was much higher than that in air. It was also found that the crack velocity increased with increasing temperature. It is considered that temperature and water have significant influences on subcritical crack growth in marble. For Carrara marble in air, it was recognized that the value of subcritical crack growth index became low when the crack velocity was higher than 10-4 m/s. This is similar to Region II of subcritical crack growth

  8. Epithelioid Schwannomas: An Analysis of 58 Cases Including Atypical Variants.

    PubMed

    Hart, Jesse; Gardner, Jerad M; Edgar, Mark; Weiss, Sharon W

    2016-05-01

    The histologic features and outcome of 58 cases of epithelioid schwannoma were studied to determine the significance of atypical histologic features. Cases were retrieved from personal consultation files from 1999 to 2013. Patients (31 male and 26 female patients) ranged in age from 14 to 80 years (median, 38 y). Two patients had schwannomatosis 1. Tumors developed in the dermis/subcutis (n=56) or muscle (n=2) of the upper extremity (34.5%), lower extremity (34.5%), thorax/abdomen/back (18%), and less common anatomic locations including the scalp, neck, lip, and breast. They ranged in size from 0.25 to 4.5 cm (median, 2.0 cm). Typically circumscribed and surrounded by a perineurium, they comprised single or small groups of epithelioid schwann cells with a moderate amphophilic cytoplasm and occasional nuclear pseudoinclusions. Stroma varied from myxoid to hyalinized, often with thick-walled vessels (55 cases). Mitotic rate ranged from 0 to 9 mitoses/10 high-power field (HPF) (2.37 mm) in the most active areas (mean, 2 to 3 mitoses/10 HPFs). Thirteen cases (22%) were "atypical," defined by a high mitotic rate (≥3 mitoses per 10 HPFs) and nuclear size variation (≥3:1). All (56/56) expressed S100 protein; type IV collagen invested groups or individual cells (16/17). Melanoma markers were negative, except for melan A (1 case). Follow-up in 39 patients (median, 78 mo; range, 6 to 174 mo) indicated that 31 (79%) were alive without disease (including 9/13 atypical cases; median, 78 mo), 7 (18%) were alive with unknown status, and 1 patient had died of unrelated causes. One tumor recurred, but none metastasized. Epithelioid schwannomas, even those with atypical features, are benign and do not constitute a histologic continuum with epithelioid malignant peripheral nerve sheath tumors, which typically occur in deep soft tissues and have more anaplastic features. PMID:26752543

  9. Theoretical analysis of the subcritical experiments performed in the IPEN/MB-01 research reactor facility

    SciTech Connect

    Lee, S. M.; Dos Santos, A.

    2012-07-01

    The theoretical analysis of the subcritical experiments performed at the IPEN/MB-01 reactor employing the coupled NJOY/AMPX-II/TORT systems was successfully accomplished. All the analysis was performed employing ENDF/B-VII.0. The theoretical approach follows all the steps of the subcritical model of Gandini and Salvatores. The theory/experiment comparison reveals that the calculated subcritical reactivity is in a very good agreement to the experimental values. The subcritical index ({xi}) shows some discrepancies although in this particular case some work still have to be made to model in a better way the neutron source present in the experiments. (authors)

  10. A Case for Including Transactions in OpenMP

    SciTech Connect

    Wong, M; Bihari, B L; de Supinski, B R; Wu, P; Michael, M; Liu, Y; Chen, W

    2010-01-25

    Transactional Memory (TM) has received significant attention recently as a mechanism to reduce the complexity of shared memory programming. We explore the potential of TM to improve OpenMP applications. We combine a software TM (STM) system to support transactions with an OpenMP implementation to start thread teams and provide task and loop-level parallelization. We apply this system to two application scenarios that reflect realistic TM use cases. Our results with this system demonstrate that even with the relatively high overheads of STM, transactions can outperform OpenMP critical sections by 10%. Overall, our study demonstrates that extending OpenMP to include transactions would ease programming effort while allowing improved performance.

  11. Evaluating Subcriticality during the Ebola Epidemic in West Africa.

    PubMed

    Enanoria, Wayne T A; Worden, Lee; Liu, Fengchen; Gao, Daozhou; Ackley, Sarah; Scott, James; Deiner, Michael; Mwebaze, Ernest; Ip, Wui; Lietman, Thomas M; Porco, Travis C

    2015-01-01

    The 2014-2015 Ebola outbreak is the largest and most widespread to date. In order to estimate ongoing transmission in the affected countries, we estimated the weekly average number of secondary cases caused by one individual infected with Ebola throughout the infectious period for each affected West African country using a stochastic hidden Markov model fitted to case data from the World Health Organization. If the average number of infections caused by one Ebola infection is less than 1.0, the epidemic is subcritical and cannot sustain itself. The epidemics in Liberia and Sierra Leone have approached subcriticality at some point during the epidemic; the epidemic in Guinea is ongoing with no evidence that it is subcritical. Response efforts to control the epidemic should continue in order to eliminate Ebola cases in West Africa. PMID:26484544

  12. Neutrino physics with accelerator driven subcritical reactors

    NASA Astrophysics Data System (ADS)

    Ciuffoli, Emilio; Evslin, Jarah; Zhao, Fengyi

    2016-01-01

    Accelerator driven system (ADS) subcritical nuclear reactors are under development around the world. They will be intense sources of free, 30-55 MeV μ + decay at rest {overline{ν}}_{μ } . These ADS reactor neutrinos can provide a robust test of the LSND anomaly and a precise measurement of the leptonic CP-violating phase δ, including sign(cos(δ)). The first phase of many ADS programs includes the construction of a low energy, high intensity proton or deuteron accelerator, which can yield competitive bounds on sterile neutrinos.

  13. A family cluster of tuberculosis cases, including a case of acquired multidrug resistant tuberculosis.

    PubMed

    Holden, Julie; Trachtman, Louis

    2012-01-01

    Although the number of tuberculosis cases in the US is at an all-time low, with progressive declines seen for the past 17 years, many goals in the tuberculosis elimination process remain unrealized. This report describes a cluster of four tuberculosis cases in a family, including one case of acquired multidrug resistant tuberculosis. It also underscores some important issues in tuberculosis control today, including significant disparities in the foreign-born population with multidrug resistant tuberculosis as a looming problem, as well as utilization of therapeutic drug level monitoring in complicated cases. PMID:22533114

  14. Core Subcriticality as a Tool of Safety Enhancement

    SciTech Connect

    Bokov, Pavel M.

    2005-11-15

    Core subcriticality can play an important role if the safety enhancement of a nuclear system is necessary, in particular, when minor actinides submitted for transmutation cause essential degradation of the reactivity feedback effects or/and significant reduction of the delayed neutron fraction. The present work shows that core subcriticality together with thermohydraulics optimization can compensate for the possible degradation of the Doppler effect and the reduction of the delayed neutron fraction. The particular dependence of the spallation neutron yield allows the creation of a supplementary negative feedback effect in case of accelerator coupled hybrid systems. A number of quantitative examples are provided in this context.

  15. Modeling new coal projects: supercritical or subcritical?

    SciTech Connect

    Carrino, A.J.; Jones, R.B.

    2006-11-15

    Decisions made on new build coal-fired plants are driven by several factors - emissions, fuel logistics and electric transmission access all provide constraints. The crucial economic decision whether to build supercritical or subcritical units often depends on assumptions concerning the reliability/availability of each technology, the cost of on-fuel operations including maintenance, the generation efficiencies and the potential for emissions credits at some future value. Modeling the influence of these key factors requires analysis and documentation to assure the assets actually meet the projected financial performance. This article addresses some of the issue related to the trade-offs that have the potential to be driven by the supercritical/subcritical decision. Solomon Associates has been collecting cost, generation and reliability data on coal-fired power generation assets for approximately 10 years using a strict methodology and taxonomy to categorize and compare actual plant operations data. This database provides validated information not only on performance, but also on alternative performance scenarios, which can provide useful insights in the pro forma financial analysis and models of new plants. 1 ref., 1 fig., 3 tabs.

  16. Massive subcritical compact arrays of plutonium metal

    SciTech Connect

    Rothe, R.E.

    1998-04-01

    Two experimental critical-approach programs are reported. Both were performed at the Rocky Flats Plant near Denver, Colorado; and both date back to the late 1960s. Both involve very large arrays of massive plutonium ingots. These ingots had been cast in the foundry at the Rocky Flats Plant as part of their routine production operations; they were not specially prepared for either study. Consequently, considerable variation in ingot mass is encountered. This mass varied between approximately 7 kg and a little more than 10 kg. One program, performed in the spring of 1969, involved stacked arrays of ingots contained within cylindrical, disk-shaped, thin, steel cans. This program studied four arrays defined by the pattern of steel cans in a single layer. The four were: 1 x N, 3 x N, 2 x 2 x N, and 3 x 3 x N. The second was a tightly-packed, triangular-pitched patterns; the last two were square-pitched patterns. The other program, performed about a year earlier, involved similar ingots also contained in similar steel cans, but these canned plutonium ingots were placed in commercial steel drums. This study pertained to one-, two-, and three-layered horizontal arrays of drums. All cases proved to be well subcritical. Most would have remained subcritical had the parameters of the array under study been continued infinitely beyond the reciprocal multiplication safety limit. In one case for the drum arrays, an uncertain extrapolation of the data of the earlier program suggests that criticality might have eventually been attained had several thousand additional kilograms of plutonium been available for use.

  17. [Spondylocostal dysostosis. Report of 5 cases including siblings and an atypical case].

    PubMed

    Pfeiffer, R A; Hansen, H G; Böwing, B; Tietze, U

    1983-01-01

    Spondylocostal Dysostosis (sp. c. D.) is characterized by multiple morphological anomalies of the vertebrae and ribs which are frequently fused. This is due to malsegmentation of the axial skeleton probably before the 20th day of embryonic development. There are severe and moderate forms. The etiology is heterogeneous since dominant, and more frequently recessive inheritance has been noted and phenocopies should be expected. Sp. c. D. may be part of a genetic malformation syndrome. Five observations are reported, three typical including sibs, and two atypical ones. The sixth case demonstrates rachischisis anterior (et posterior) of the entire spine. PMID:6835216

  18. A thermodynamic analysis of propagating subcritical cracks with cohesive zones

    NASA Technical Reports Server (NTRS)

    Allen, David H.

    1993-01-01

    The results of the so-called energetic approach to fracture with particular attention to the issue of energy dissipation due to crack propagation are applied to the case of a crack with cohesive zone. The thermodynamic admissibility of subcritical crack growth (SCG) is discussed together with some hypotheses that lead to the derivation of SCG laws. A two-phase cohesive zone model for discontinuous crack growth is presented and its thermodynamics analyzed, followed by an example of its possible application.

  19. Subcritical crack growth under mode I, II, and III loading for Coconino sandstone

    NASA Astrophysics Data System (ADS)

    Ko, Tae Young

    of 34 to 38 and the parameter A has the range of 1.02x10-2 to 6.52x10-2 m/s. The effect of confining stress, specimen size, and water saturation on subcritical crack growth under mode II loading has also been investigated. Finally strength parameters for Coconino sandstone were determined experimentally, including tensile strength, uniaxial compressive strength, cohesion, internal friction angle, in-plane/our-of-plane shear strength and the fracture toughness under mode I, II, and III loading.

  20. ENHANCED ELECTROCHEMICAL PROCESSES IN SUBCRITICAL WATER

    SciTech Connect

    Steven B. Hawthorne

    2000-07-01

    This project involved designing and performing preliminary electrochemical experiments in subcritical water. An electrochemical cell with substantially better performance characteristics than presently available was designed, built, and tested successfully. The electrochemical conductivity of subcritical water increased substantially with temperature, e.g., conductivities increased by a factor of 120 when the temperature was increased from 25 to 250 C. Cyclic voltammograms obtained with platinum and nickel demonstrated that the voltage required to produce hydrogen and oxygen from water can be dropped by a factor of three in subcritical water compared to the voltages required at ambient temperatures. However, no enhancement in the degradation of 1,2-dichlorobenzene and the polychlorinated biphenyl 3,3',4,4'-tetrachlorobiphenyl was observed with applied potential in subcritical water.

  1. Discriminators for the Accelerator-Based Conversion (ABC) concept using a subcritical molten salt system

    SciTech Connect

    Arthur, E.; Busksa, J.; Davidson, W.; Poston, D.

    1995-05-01

    Discriminators are described that quantify enhancements added to plutonium destruction and/or nuclear waste transmutation systems through use of an accelerator/fluid fuel combination. This combination produces a robust and flexible nuclear system capable of the destruction of all major long-lived actinides (including plutonium) and fission products. The discriminators discussed in this report are (1) impact of subcritical operation on safety, (2) impact of subcritical and fluid fuel operation on plutonium burnout scenarios, and (3) neutron economy enhancements brought about by subcritical operation. Neutron economy enhancements are quantified through assessment of long-term dose reduction resulting from transmutation of key fission products along with relaxation of processing frequencies afforded by subcritical operation.

  2. Cygnus Performance in Subcritical Experiments

    SciTech Connect

    G. Corrow, M. Hansen, D. Henderson, S. Lutz, C. Mitton, et al.

    2008-02-01

    The Cygnus Dual Beam Radiographic Facility consists of two identical radiographic sources with the following specifications: 4-rad dose at 1 m, 1-mm spot size, 50-ns pulse length, 2.25-MeV endpoint energy. The facility is located in an underground tunnel complex at the Nevada Test Site. Here SubCritical Experiments (SCEs) are performed to study the dynamic properties of plutonium. The Cygnus sources were developed as a primary diagnostic for these tests. Since SCEs are single-shot, high-value events - reliability and reproducibility are key issues. Enhanced reliability involves minimization of failure modes through design, inspection, and testing. Many unique hardware and operational features were incorporated into Cygnus to insure reliability. Enhanced reproducibility involves normalization of shot-to-shot output also through design, inspection, and testing. The first SCE to utilize Cygnus, Armando, was executed on May 25, 2004. A year later, April - May 2005, calibrations using a plutonium step wedge were performed. The results from this series were used for more precise interpretation of the Armando data. In the period February - May 2007 Cygnus was fielded on Thermos, which is a series of small-sample plutonium shots using a one-dimensional geometry. Pulsed power research generally dictates frequent change in hardware configuration. Conversely, SCE applications have typically required constant machine settings. Therefore, while operating during the past four years we have accumulated a large database for evaluation of machine performance under highly consistent operating conditions. Through analysis of this database Cygnus reliability and reproducibility on Armando, Step Wedge, and Thermos is presented.

  3. High-value use of weapons-plutonium by burning in molten salt accelerator-driven subcritical systems or reactors

    SciTech Connect

    Bowman, C.D.; Venneri, F.

    1993-11-01

    The application of thermal-spectrum molten-salt reactors and accelerator-driven subcritical systems to the destruction of weapons-return plutonium is considered from the perspective of deriving the maximum societal benefit. The enhancement of electric power production from burning the fertile fuel {sup 232}Th with the plutonium is evaluated. Also the enhancement of destruction of the accumulated waste from commercial nuclear reactors is considered using the neutron-rich weapons plutonium. Most cases examined include the concurrent transmutation of the long-lived actinide and fission product waste ({sup 99}Tc, {sup 129}I, {sup 135}Cs, {sup 126}Sn and {sup 79}Se).

  4. An experimental investigation of the subcritical and supercritical flow about a swept semispan wing

    NASA Technical Reports Server (NTRS)

    Lockman, W. K.; Seegmiller, H. L.

    1983-01-01

    An experimental investigation of the turbulent, subcritical and supercritical flow over a swept, semispan wing in a solid wall wind tunnel is described. The program was conducted over a range of Mach numbers, Reynolds numbers, and angles of attack to provide a variety of test cases for assessment of wing computer codes and tunnel wall interference effects. Wing flows both without and with three dimensional flow separation are included. Data include mean surface pressures for both the wing and tunnel walls; surface oil flow patterns on the wing; and mean velocity, flow field surveys. The results are given in tabular form and presented graphically to illustrate some of the effects of the test parameters. Comparisons of the wing pressure data with the results from two inviscid wing codes are also shown to assess the importance of viscous flow and tunnel wall effects.

  5. 30 CFR 250.415 - What must my casing and cementing programs include?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.415 What must my casing and cementing programs include? Your casing... (incorporated by reference as specified in § 250.198), if you drill a well in water depths greater than 500...

  6. Preliminary design concept of a subcritical reactor using available resources

    SciTech Connect

    Churnetski, E.L.; Hoyny, V.; Chaudhuri, B.R.; Taprantzis, A.; Yavas, A.

    1993-12-31

    During the Fall 1993 semester, a project was initiated within the Nuclear Engineering Department of the University of Tennessee with the objective of developing a design for a subcritical reactor with maximized multiplication factor using materials currently available. Such a device, if constructed, would serve as a teaching tool for the Department of Nuclear Engineering. Design work was conducted as a large number of computer calculations, with trial pile configurations based on fundamental nuclear engineering principles, in an effort to maximize multiplication factor through fuel element geometry, moderator type, fissile/moderator ratio, and reflector character. The principal objective of the design group for the early phase of this project was to present several possible ``baseline`` reactor designs and identify directions for improvements. For the sake of calculational ease, the cores analyzes to date have been of nearly cubic shape. The SCALE CSAS25 software which runs KENO.Va, a Monte Carlo code, was used for all neutronics calculations. The baseline reactors resulting from work to date are cuboidal in shape and graphite reflected. Two types of fuel element geometries are proposed, a typical triangular pitch rod lattice and an arrangement of discrete fuel slugs placed in a lattice corresponding to body centered cubic packing. The latter arrangement provides slightly higher multiplication factors than the former. Calculations were performed for both graphite and heavy water moderation with heavy water moderation producing considerably higher multiplication factors, as expected. In general, the maximum k{sub eff} for the reactors are in the range of 0.5 to 0.9, well subcritical, except in the cases of the extreme possible values of fuel assay where critical configurations are possible. In these cases, designs with reduced fuel loading are recommended to assure a subcritical multiplication factor.

  7. Detector positioning for the initial subcriticality level determination in accelerator-driven systems

    SciTech Connect

    Uyttenhove, W.; Van Den Eynde, G.; Baeten, P.; Kochetkov, A.; Vittiglio, G.; Wagemans, J.; Lathouwers, D.; Kloosterman, J. L.; Van Der Hagen, T. J. H. H.; Wols, F.; Billebaud, A.; Chabod, S.; Thybault, H. E.

    2012-07-01

    Within the GUINEVERE project (Generation of Uninterrupted Intense Neutrons at the lead Venus Reactor) carried out at SCK-CEN in Mol, the continuous deuteron accelerator GENEPI-3C was coupled to the VENUS-F fast simulated lead-cooled reactor. Today the FREYA project (Fast Reactor Experiments for hYbrid Applications) is ongoing to study the neutronic behavior of this Accelerator Driven System (ADS) during different phases of operation. In particular the set-up of a monitoring system for the subcriticality of an ADS is envisaged to guarantee safe operation of the installation. The methodology for subcriticality monitoring in ADS takes into account the determination of the initial subcriticality level, the monitoring of reactivity variations, and interim cross-checking. At start-up, the Pulsed Neutron Source (PNS) technique is envisaged to determine the initial subcriticality level. Thanks to its reference critical state, the PNS technique can be validated on the VENUS-F core. A detector positioning methodology for the PNS technique is set up in this paper for the subcritical VENUS-F core, based on the reduction of higher harmonics in a static evaluation of the Sjoestrand area method. A first case study is provided on the VENUS-F core. This method can be generalised in order to create general rules for detector positions and types for full-scale ADS. (authors)

  8. Orbital storage and supply of subcritical liquid nitrogen

    NASA Technical Reports Server (NTRS)

    Aydelott, John C.

    1990-01-01

    Subcritical cryogenic fluid management has long been recognized as an enabling technology for key propulsion applications, such as space transfer vehicles (STV) and the on-orbit cryogenic fuel depots which will provide STV servicing capability. The LeRC Cryogenic Fluids Technology Office (CFTO), under the sponsorship of OAST, has the responsibility of developing the required technology via a balanced program involving analytical modeling, ground based testing, and in-space experimentation. Topics covered in viewgraph form include: cryogenic management technologies; nitrogen storage and supply; cryogenic nitrogen cooling capability; and LN2 system demonstration technical objectives.

  9. Subcritical crack growth and mechanical weathering: a new consideration of how moisture influences rock erosion rates.

    NASA Astrophysics Data System (ADS)

    Eppes, Martha-Cary; Keanini, Russell; Hancock, Gregory S.

    2016-04-01

    The contributions of moisture to the mechanical aspects of rock weathering and regolith production are poorly quantified. In particular, geomorphologists have largely overlooked the role of subcritical crack growth processes in physical weathering and the fact that moisture strongly influences the rates of those processes. This influence is irrespective of the function that moisture plays in stress loading mechanisms like freezing or hydration. Here we present a simple numerical model that explores the efficacy of subcritical crack growth in granite rock subaerially exposed under a range of moisture conditions. Because most weathering-related stress loading for rocks found at, or near, Earth's surface (hereafter surface rocks) is cyclic, we modeled crack growth using a novel combination of Paris' Law and Charles' Law. This combination allowed us to apply existing empirically-derived data for the stress corrosion index of Charles' Law to fatigue cracking. For stress, we focused on the relatively straightforward case of intergranular stresses that arise during solar-induced thermal cycling by conductive heat transfer, making the assumption that such stresses represent a universal minimum weathering stress experienced by all surface rocks. Because all other tensile weathering-related stresses would be additive in the context of crack growth, however, our model can be adapted to include other stress loading mechanisms. We validated our calculations using recently published thermal-stress-induced cracking rates. Our results demonstrate that 1) weathering-induced stresses as modeled herein, and as published by others, are sufficient to propagate fractures subcritically over long timescales with or without the presence of water 2) fracture propagation rates increase exponentially with respect to moisture, specifically relative humidity 3) fracture propagation rates driven by thermal cycling are strongly dependent on the magnitude of diurnal temperature ranges and the

  10. REMOVAL OF ORGANIC POLLUTANTS FROM SUBCRITICAL WATER WITH ACTIVATED CARBON

    SciTech Connect

    Steven B. Hawthorne; Arnaud J. Lagadec

    1999-08-01

    The Energy & Environmental Research Center (EERC) has demonstrated that controlling the temperature (and to a lesser extent, the pressure) of water can dramatically change its ability to extract organics and inorganics from matrices ranging from soils and sediments to waste sludges and coal. The dielectric constant of water can be changed from about 80 (a very polar solvent) to <5 (similar to a nonpolar organic solvent) by controlling the temperature (from ambient to about 400 C) and pressure (from about 5 to 350 bar). The EERC has shown that hazardous organic pollutants such as pesticides, PACS (polycyclic aromatic hydrocarbons), and PCBs (polychlorinated biphenyls) can be completely removed from soils, sludges, and sediments at temperatures (250 C) and pressures (<50 atm) that are much milder than typically used for supercritical water processes (temperature >374 C, pressure >221 atm). In addition, the process has been demonstrated to be particularly effective for samples containing very high levels of contaminants (e.g., part per thousand). Current projects include demonstrating the subcritical water remediation process at the pilot scale using an 8-liter system constructed under separate funding during 1997. To date, subcritical water has been shown to be an effective extraction fluid for removing a variety of organic pollutants from soils and sludges contaminated with fossil fuel products and waste products, including PACS from soil (e.g., town gas sites), refining catalysts, and petroleum tank bottom sludges; PCBs from soil and sediments; toxic gasoline components (e.g., benzene) from soil and waste sludge; and phenols from petroleum refinery sludges. The obvious need to clean the wastewater from subcritical water processes led to preliminary experiments with activated carbon placed in line after the extractor. Initial experiments were performed before and after cooling the extractant water (e.g., with water at 200 C and with water cooled to 25 C

  11. 30 CFR 250.527 - What must I include in my casing pressure request?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... following information must be included in the casing pressure request: (a) API number; (b) Lease number; (c... and the calculated daily production rate during last well test (oil, gas, basic sediment, and water... (dry tree, hybrid, or subsea); (n) Date of diagnostic test; (o) Well schematic; (p) Water depth;...

  12. Magma-driven subcritical crack growth and implications for dike initiation from a magma chamber

    NASA Astrophysics Data System (ADS)

    Chen, Zuan; Jin, Z.-H.

    2006-10-01

    The purpose of this paper is to explore a viscoelastic energy dissipation theory for subcritical dike growth from a magma chamber. The theoretical relationship between the dike growth velocity and dike length is established using the viscoelastic subcritical crack growth theory proposed by the first author and the solutions of stress intensity factor at the crack tip derived by a perturbation method. Effects of magma chamber over-pressure, buoyancy and viscoelastic properties of the host rock on the subcritical growth rate are included in the model. The numerical results indicate that the viscous energy dissipation of the host rock could allow a short dike to slowly grow on the order of 10-7-10-5 m/s under modest over-pressure and to accelerate when the stress intensity factor increases close to the fracture toughness, followed by the unstable dike propagation. The proposed theory provides a reasonable understanding of dike initiation process from a magma chamber.

  13. Nested subcritical flows within supercritical systems

    NASA Technical Reports Server (NTRS)

    Hendricks, R. C.; Braun, M. J.; Wheeler, R. L., III; Mullen, R. L.

    1985-01-01

    In supercritical systems the design inlet and outlet pressures are maintained above the thermaodynamic critical pressure P sub C. Designers rely on this simple rule of thumb to circumvent problems associated with a subcritical pressure regime nested within the supercritical pressure system along with the uncertainties in heat transfer, fluid mechanics, and thermophysical property variations. The simple rule of thumb is adequate in many low-power designs but is inadequate for high-performance turbomachines and linear systems, where nested two-phase regions can exist. Examples for a free-jet expansion with backpressure greater than P sub C and a rotor (bearing) with ambient pressure greater than P sub C illustrate the existence of subcritical pressure regimes nested within supercritical systems.

  14. Subcritical string and large N QCD

    SciTech Connect

    Thorn, Charles B.

    2008-10-15

    We pursue the possibility of using subcritical string theory in 4 spacetime dimensions to establish a string dual for large N QCD. In particular we study the even G-parity sector of the 4 dimensional Neveu-Schwarz dual resonance model as the natural candidate for this string theory. Our point of view is that the open string dynamics given by this model will determine the appropriate subcritical closed string theory, a tree level background of which should describe the sum of planar multiloop open string diagrams. We examine the one-loop open string diagram, which contains information about the closed string spectrum at weak coupling. Higher loop open string diagrams will be needed to determine closed string interactions. We also analyze the field theory limit of the one-loop open string diagram and recover the correct running coupling behavior of the limiting gauge theory.

  15. Accelerators for Subcritical Molten-Salt Reactors

    SciTech Connect

    Johnson, Roland

    2011-08-03

    Accelerator parameters for subcritical reactors have usually been based on using solid nuclear fuel much like that used in all operating critical reactors as well as the thorium burning accelerator-driven energy amplifier proposed by Rubbia et al. An attractive alternative reactor design that used molten salt fuel was experimentally studied at ORNL in the 1960s, where a critical molten salt reactor was successfully operated using enriched U235 or U233 tetrafluoride fuels. These experiments give confidence that an accelerator-driven subcritical molten salt reactor will work better than conventional reactors, having better efficiency due to their higher operating temperature, having the inherent safety of subcritical operation, and having constant purging of volatile radioactive elements to eliminate their accumulation and potential accidental release in dangerous amounts. Moreover, the requirements to drive a molten salt reactor can be considerably relaxed compared to a solid fuel reactor, especially regarding accelerator reliability and spallation neutron targetry, to the point that much of the required technology exists today. It is proposed that Project-X be developed into a prototype commercial machine to produce energy for the world by, for example, burning thorium in India and nuclear waste from conventional reactors in the USA.

  16. Neutron noise measurements at the Delphi subcritical assembly

    SciTech Connect

    Szieberth, M.; Klujber, G.; Kloosterman, J. L.; De Haas, D.

    2012-07-01

    The paper presents the results and evaluations of a comprehensive set of neutron noise measurements on the Delphi subcritical assembly of the Delft Univ. of Technology. The measurements investigated the effect of different source distributions (inherent spontaneous fission and {sup 252}Cf) and the position of the detectors applied (both radially and vertically). The evaluation of the measured data has been performed by the variance-to-mean ratio (VTMR, Feynman-{alpha}), the autocorrelation (ACF, Rossi-{alpha}) and the cross-correlation (CCF) methods. The values obtained for the prompt decay constant show a strong bias, which depends both on the detector position and on the source distribution. This is due to the presence of higher modes in the system. It has been observed that the {alpha} value fitted is higher when the detector is close to the boundary of the core or to the {sup 252}Cf point-source. The higher alpha-modes have also been observed by fitting functions describing two alpha-modes. The successful set of measurement also provides a good basis for further theoretical investigations including the Monte Carlo simulation of the noise measurements and the calculation of the alpha-modes in the Delphi subcritical assembly. (authors)

  17. Subcritical Water Processing of Proteins: An Alternative to Enzymatic Digestion?

    PubMed

    Powell, Thomas; Bowra, Steve; Cooper, Helen J

    2016-06-21

    Subcritical water is an emerging tool in the processing of bioorganic waste. Subcritical water is an environmentally benign solvent which has the potential to provide an alternative to traditional methods of protein hydrolysis without the inclusion of expensive acids or enzymes. To date, most studies on the subcritical water mediated hydrolysis of proteins have focused on the production of amino acids, rather than the intermediate peptides. Here, we investigate the specificity of subcritical water with respect to the production of peptides from three model proteins, hemoglobin, bovine serum albumin, and β-casein, and compare the results with enzymatic digestion of proteins by trypsin. In addition, the effect of subcritical water (SCW) treatment on two protein post-translational modifications, disulfide bonds and phosphorylation, was investigated. The results show that high protein sequence coverages (>80%) can be obtained following subcritical water hydrolysis. These are comparable to those obtained following treatment with tryspin. Under mild subcritical water conditions (160 °C), all proteins showed favored cleavage of the Asp-X bond. The results for β-casein revealed favored cleavage of the Glu-X bond at subcritical water temperatures of 160 and 207 °C. That was similarly observed for bovine serum albumin at a subcritical water temperature of 207 °C. Subcritical water treatment results in very limited cleavage of disulfide bonds. Reduction and alkylation of proteins either prior to or post subcritical water treatment improve reported protein sequence coverages. The results for phosphoprotein β-casein show that, under mild subcritical water conditions, phosphorylation may be retained on the peptide hydrolysis products. PMID:27181872

  18. Women convicted of a sexual offence, including child pornography production: two case reports.

    PubMed

    Prat, S; Bertsch, I; Chudzik, L; Réveillère, Ch

    2014-03-01

    All available studies addressing the clinical and legal aspects of child pornography have systematically concerned male abusers. The social lens through which women are viewed tends to play down their responsibility in the sexual abuse of children. Unlike men, women rarely abuse children outside the close or family circle. Furthermore, they have frequently been abused themselves in their childhood. To our knowledge, no cases of women charged with sex-related offences, including child pornography, have been described in the literature. The psychopathological characteristics of female sexual abusers and of the two women in our cases tend to suggest that the deliberate downloading of child pornography images by women is unusual, as their deviant behaviour is not related to paedophile sexual arousal It is hypothesized that the act enables women perpetrators to satisfy the sexual urges of their spouse. Sexual abuse by women exists, but the nature of the abuse appears to be specific to the gender of the perpetrator. We present two cases of women charged with sexual offences concerning minors, including the production of child pornography material. PMID:24661700

  19. Upper Subcritical Calculations Based on Correlated Data

    SciTech Connect

    Sobes, Vladimir; Rearden, Bradley T; Mueller, Don; Marshall, William BJ J; Scaglione, John M; Dunn, Michael E

    2015-01-01

    The American National Standards Institute and American Nuclear Society standard for Validation of Neutron Transport Methods for Nuclear Criticality Safety Calculations defines the upper subcritical limit (USL) as “a limit on the calculated k-effective value established to ensure that conditions calculated to be subcritical will actually be subcritical.” Often, USL calculations are based on statistical techniques that infer information about a nuclear system of interest from a set of known/well-characterized similar systems. The work in this paper is part of an active area of research to investigate the way traditional trending analysis is used in the nuclear industry, and in particular, the research is assessing the impact of the underlying assumption that the experimental data being analyzed for USL calculations are statistically independent. In contrast, the multiple experiments typically used for USL calculations can be correlated because they are often performed at the same facilities using the same materials and measurement techniques. This paper addresses this issue by providing a set of statistical inference methods to calculate the bias and bias uncertainty based on the underlying assumption that the experimental data are correlated. Methods to quantify these correlations are the subject of a companion paper and will not be discussed here. The newly proposed USL methodology is based on the assumption that the integral experiments selected for use in the establishment of the USL are sufficiently applicable and that experimental correlations are known. Under the assumption of uncorrelated data, the new methods collapse directly to familiar USL equations currently used. We will demonstrate our proposed methods on real data and compare them to calculations of currently used methods such as USLSTATS and NUREG/CR-6698. Lastly, we will also demonstrate the effect experiment correlations can have on USL calculations.

  20. Metastatic atypical fibroxanthoma: a series of 11 cases including with minimal and no subcutaneous involvement.

    PubMed

    Wang, Wei-Lien; Torres-Cabala, Carlos; Curry, Jonathan L; Ivan, Doina; McLemore, Michael; Tetzlaff, Michael; Zembowicz, Artur; Prieto, Victor G; Lazar, Alexander J

    2015-06-01

    Atypical fibroxanthoma (AFX) is a dermal mesenchymal neoplasm arising in sun-damaged skin, primarily of the head and neck region of older men. Conservative excision cures most. However, varying degrees of subcutaneous involvement can lead to a more aggressive course and rare metastases. Thus, AFX involving the subcutis are termed pleomorphic dermal sarcomas or other monikers by some to recognize the more threatening natural history. We reviewed cases of "metastatic AFX" from our institution and from the files of a consultative dermatopathology practice. Nine of 152 patients with AFX were identified at a single institution (2000-2011). Two additional patients were identified from the files of a consultative practice. Clinical, radiological, and pathological features were reviewed and cases with histologically verified metastases identified. Median age was 67 (range, 45-91) years, all male, and involving the head and neck region. Two cases had no documented involvement of the subcutis, and 2 cases had only superficial subcutis involvement. Median time to metastases was 13 (range, 8-49) months. Three patients developed solitary regional lymph node metastases while 8 had widespread metastases. Five patients developed local recurrence within 8 months, and all 5 developed widespread metastasis. With median follow-up of 26 (range, 10-145) months, 6 died of disease (median, 19 months; range, 10-35 months), 4 were alive and well, and 1 was alive with disease. AFX has very rare metastatic potential, even those without or with minimal subcutis involvement, and can lead to mortality. Most metastasis and local recurrence occurred within 1 year of presentation. Solitary regional metastases were associated with better outcomes than those with multiple distant metastases. Patients with repeated local recurrences portended more aggressive disease including development of distant metastases. PMID:25590287

  1. Review of Subcritical Source-Driven Noise Analysis Measurements

    SciTech Connect

    Valentine, T.E.

    1999-11-24

    Subcritical source-driven noise measurements are simultaneous Rossi-{alpha} and randomly pulsed neutron measurements that provide measured quantities that can be related to the subcritical neutron multiplication factor. In fact, subcritical source-driven noise measurements should be performed in lieu of Rossi-{alpha} measurements because of the additional information that is obtained from noise measurements such as the spectral ratio and the coherence functions. The basic understanding of source-driven noise analysis measurements can be developed from a point reactor kinetics model to demonstrate how the measured quantities relate to the subcritical neutron multiplication factor. More elaborate models can also be developed using a generalized stochastic model. These measurements can be simulated using Monte Carlo codes to determine the subcritical neutron multiplication factor or to determine the sensitivity of calculations to nuclear cross section data. The interpretation of the measurement using a Monte Carlo method is based on a perturbation model for the relationship between the spectral ratio and the subcritical neutron multiplication factor. The subcritical source-driven noise measurement has advantages over other subcritical measurement methods in that reference measurements at delayed critical are not required for interpreting the measurements. Therefore, benchmark or in-situ subcritical measurements can be performed outside a critical experiment facility. Furthermore, a certain ratio of frequency spectra has been shown to be independent of detection efficiency thereby making the measurement more robust and unaffected by drifts or changes in instrumentation during the measurement. Criteria have been defined for application of this measurement method for benchmarks and in-situ subcritical measurements. An extension of the source-driven subcritical noise measurement has also been discussed that eliminates the few technical challenges for in-situ applications.

  2. Subcritical water extraction of organic matter from sedimentary rocks.

    PubMed

    Luong, Duy; Sephton, Mark A; Watson, Jonathan S

    2015-06-16

    Subcritical water extraction of organic matter containing sedimentary rocks at 300°C and 1500 psi produces extracts comparable to conventional solvent extraction. Subcritical water extraction of previously solvent extracted samples confirms that high molecular weight organic matter (kerogen) degradation is not occurring and that only low molecular weight organic matter (free compounds) are being accessed in analogy to solvent extraction procedures. The sedimentary rocks chosen for extraction span the classic geochemical organic matter types. A type I organic matter-containing sedimentary rock produces n-alkanes and isoprenoidal hydrocarbons at 300°C and 1500 psi that indicate an algal source for the organic matter. Extraction of a rock containing type II organic matter at the same temperature and pressure produces aliphatic hydrocarbons but also aromatic compounds reflecting the increased contributions from terrestrial organic matter in this sample. A type III organic matter-containing sample produces a range of non-polar and polar compounds including polycyclic aromatic hydrocarbons and oxygenated aromatic compounds at 300°C and 1500 psi reflecting a dominantly terrestrial origin for the organic materials. Although extraction at 300°C and 1500 psi produces extracts that are comparable to solvent extraction, lower temperature steps display differences related to organic solubility. The type I organic matter produces no products below 300°C and 1500 psi, reflecting its dominantly aliphatic character, while type II and type III organic matter contribute some polar components to the lower temperature steps, reflecting the chemical heterogeneity of their organic inventory. The separation of polar and non-polar organic compounds by using different temperatures provides the potential for selective extraction that may obviate the need for subsequent preparative chromatography steps. Our results indicate that subcritical water extraction can act as a suitable

  3. Subcritical water extraction of lipids from wet algal biomass

    DOEpatents

    Deng, Shuguang; Reddy, Harvind K.; Schaub, Tanner; Holguin, Francisco Omar

    2016-05-03

    Methods of lipid extraction from biomass, in particular wet algae, through conventionally heated subcritical water, and microwave-assisted subcritical water. In one embodiment, fatty acid methyl esters from solids in a polar phase are further extracted to increase biofuel production.

  4. Spinal meningiomas in dogs: Description of 8 cases including a novel radiological and histopathological presentation

    PubMed Central

    José-López, Roberto; de la Fuente, Cristian; Pumarola, Martí; Añor, Sonia

    2013-01-01

    Clinical, imaging, and histological features of 8 canine spinal meningiomas, including a cervical cystic meningioma with imaging and intraoperative features of an arachnoid cyst, are described. All meningiomas were histologically classified and graded following the international World Health Organization human classification for tumors. Six meningiomas were located in the cervical spinal cord. Myelography showed intradural/ extramedullary lesions in 3/4 cases. Magnetic resonance imaging revealed hyperintense intradural/extramedullary masses on pre-contrast T1-weighted and T2-weighted images with homogeneous contrast enhancement in 7/8 cases. One dog had a cerebrospinal fluid-filled subarachnoid cavity dorsal to the cervical spinal cord. A spinal arachnoid cyst was diagnosed on imaging, but the histopathological study of the resected tissue revealed a grade I meningothelial cystic meningioma. There were no differences in outcome associated with tumor grade and surgical treatment (6/8). Cystic meningioma should be considered in the differential diagnosis of intraspinal cystic lesions, and biopsy is necessary for definitive diagnosis. PMID:24155414

  5. Spinal meningiomas in dogs: description of 8 cases including a novel radiological and histopathological presentation.

    PubMed

    José-López, Roberto; de la Fuente, Cristian; Pumarola, Martí; Añor, Sonia

    2013-10-01

    Clinical, imaging, and histological features of 8 canine spinal meningiomas, including a cervical cystic meningioma with imaging and intraoperative features of an arachnoid cyst, are described. All meningiomas were histologically classified and graded following the international World Health Organization human classification for tumors. Six meningiomas were located in the cervical spinal cord. Myelography showed intradural/ extramedullary lesions in 3/4 cases. Magnetic resonance imaging revealed hyperintense intradural/extramedullary masses on pre-contrast T1-weighted and T2-weighted images with homogeneous contrast enhancement in 7/8 cases. One dog had a cerebrospinal fluid-filled subarachnoid cavity dorsal to the cervical spinal cord. A spinal arachnoid cyst was diagnosed on imaging, but the histopathological study of the resected tissue revealed a grade I meningothelial cystic meningioma. There were no differences in outcome associated with tumor grade and surgical treatment (6/8). Cystic meningioma should be considered in the differential diagnosis of intraspinal cystic lesions, and biopsy is necessary for definitive diagnosis. PMID:24155414

  6. Physiological properties of Scomber japonicus meat hydrolysate prepared by subcritical water hydrolysis.

    PubMed

    Choi, Jae-Suk; Moon, Hye Eun; Roh, Myong-Kyun; Ha, Yu-Mi; Lee, Bo-Bae; Cho, Kwang Keun; Choi, In Soon

    2016-01-01

    The health-beneficial biological activities, including antioxidant and tyrosinase inhibitory activities, of Scomber japonicus muscle protein hydrolysates prepared by subcritical water hydrolysis were investigated. After 5 min of subcritical hydrolysis at 140 degrees C, 59.76% of S. japonicus muscle protein was hydrolyzed, the highest degree of hydrolysis in all the groups were tested. According to the response surface methodology results, as the reaction temperature and reaction time became lower and shorter, the yield became higher. The highest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity (90.63%) occurred in hydrolysates treated at 140 degrees C for 5 min, and the highest tyrosinase inhibitory activity (65.54%) was identified in hydrolysates treated at 200 degreesC for 15 min. Changes in the molecular weight distribution of S. japonicus muscle proteins after subcritical water hydrolysis were observed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Subcritical water hydrolysis is a suitable technique for obtaining S.japonicus muscle protein hydrolysates with useful biological activities, within a short time (5-15 min). PMID:26930861

  7. An atypical case of fragile X syndrome caused by a deletion that includes FMRI gene

    SciTech Connect

    Quan, F.; Zonana, J.; Gunter, K.; Peterson, K.L.; Magenis, R.E., Popovich, B.W.

    1995-05-01

    Fragile X syndrome is the most common form of inherited mental retardation and results from the transcriptional inactivation of the FMR1 gene. In the vast majority of cases, this is caused by the expansion of an unstable CGG repeat in the first exon of the FMR1 gene. We describe here a phenotypically atypical case of fragile X syndrome, caused by a deletion that includes the entire FMR1 gene and {ge}9.0 Mb of flanking DNA. The proband, RK, was a 6-year-old mentally retarded male with obesity and anal atresia. A diagnosis of fragile X syndrome was established by the failure of RK`s DNA to hybridize to a 558-bp PstI-XhoI fragment (pfxa3) specific for the 5{prime}-end of the FMR1 gene. The analysis of flanking markers in the interval from Xq26.3-q28 indicated a deletion extending from between 160-500 kb distal and 9.0 Mb proximal to the FMR1 gene. High-resolution chromosome banding confirmed a deletion with breakpoints in Xq26.3 and Xq27.3. This deletion was maternally transmitted and arose as a new mutation on the grandpaternal X chromosome. The maternal transmission of the deletion was confirmed by FISH using a 34-kb cosmid (c31.4) containing most of the FMR1 gene. These results indicated that RK carried a deletion of the FMR1 region with the most proximal breakpoint described to date. This patient`s unusual clinical presentation may indicate the presence of genes located in the deleted interval proximal to the FMR1 locus that are able to modify the fragile X syndrome phenotype. 36 refs., 7 figs.

  8. 30 CFR 250.528 - What must I include in my casing pressure request?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... address; (f) All casing, riser, and tubing sizes, weights, grades, and MIYP; (g) All casing/riser calculated MAWOPs; (h) All casing/riser pre-bleed down pressures; (i) Shut-in tubing pressure; (j) Flowing tubing pressure; (k) Date and the calculated daily production rate during last well test (oil, gas,...

  9. 30 CFR 250.527 - What must I include in my casing pressure request?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... name and mailing address; (f) All casing, riser, and tubing sizes, weights, grades, and MIYP; (g) All casing/riser calculated MAWOPs; (h) All casing/riser pre-bleed down pressures; (i) Shut-in tubing pressure; (j) Flowing tubing pressure; (k) Date and the calculated daily production rate during last...

  10. 30 CFR 250.528 - What must I include in my casing pressure request?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... address; (f) All casing, riser, and tubing sizes, weights, grades, and MIYP; (g) All casing/riser calculated MAWOPs; (h) All casing/riser pre-bleed down pressures; (i) Shut-in tubing pressure; (j) Flowing tubing pressure; (k) Date and the calculated daily production rate during last well test (oil, gas,...

  11. 30 CFR 250.527 - What must I include in my casing pressure request?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... address; (f) All casing, riser, and tubing sizes, weights, grades, and MIYP; (g) All casing/riser calculated MAWOPs; (h) All casing/riser pre-bleed down pressures; (i) Shut-in tubing pressure; (j) Flowing tubing pressure; (k) Date and the calculated daily production rate during last well test (oil, gas,...

  12. Application of a boiler performance model to evaluate low-rank coal fired subcritical and supercritical boilers

    SciTech Connect

    Ahn, Y.K.; Buchanan, T.L.; Zaharchuk, R.

    1995-12-31

    A number of thermal drying processes that could be used to dry and upgrade Low-Rank Coals (LRCs) are under development. G/C evaluated these processes and selected the SynCoal process as the optimum process to dry the LRC. Initially, the evaluation was made on the basis of the cost of dried LRC, delivered to Korea, and later the evaluation was made on a cost-of-electricity (COE) basis. Two cases were evaluated: firing the dried LRC in an existing subcritical PC plant and in a new supercritical boiler. For the existing PC plant, Korea Electric Power Corporation`s (KEPCO`s) 270 MWe Honam plant was selected. A Boiler Performance Model (BPM) was used to evaluate performances of both subcritical and supercritical units for firing various coals. The results showed that upgraded Usibelli coal was marginally competitive due to its high mine-mouth cost, but Rosebud coal was very competitive due to its low mine-mouth cost. In these cases the coals were upgraded by using the SynCoal process. This report investigates the impact of tax incentives resulting from the Energy Policy Act of 1992 on the competitiveness of the upgraded Alaska Usibelli and Montana Rosebud coals for application to PC plants. The SynCoal process has been qualified by the Internal Revenue Service for tax benefits derived from the Energy Policy Act. The economic analyses include costs and sensitivity analyses for alternative ways of selling fines produced during the SynCoal process: briquetting fines and adding them to the finished product, or cooling fines and selling them to users at the same price as SynCoal product in the domestic market. These analyses included the effects of tax incentive when applicable.

  13. Microdeformation and subcritical cracking in chalk

    NASA Astrophysics Data System (ADS)

    Bergsaker, Anne; Dysthe, Dag Kristian

    2016-04-01

    Deformation processes in chalks, both in relation to changing pore fluids and stress conditions has been of great interest as chalk is an important reservoir rock for both hydrocarbons and ground water. Lately it has also gained interest as a potential reservoir rock for captured CO2. Chalks are composed of large amounts of biogenic calcite grains, the skeletal debris of marine microorganisms. Its deformation is highly time and stress dependent, and governed by a transition from distributed to localized deformation at the onset of yield, affected by mechanisms such as subcritical crack growth and pore collapse. We present a microdeformation rig which makes use of thermal expansion as a means of subjecting small samples to strictly controlled tensile stresses. High resolution imaging provides resolutions down to 0.5 micrometers, enabling study of pore scale processes during slow deformation. Examples of localized and distributed deformation are presented.

  14. Nonlinear dead water resistance at subcritical speed

    NASA Astrophysics Data System (ADS)

    Grue, John

    2015-08-01

    The dead water resistance F 1 = /1 2 C d w ρ S U 2 (ρ fluid density, U ship speed, S wetted body surface, Cdw resistance coefficient) on a ship moving at subcritical speed along the upper layer of a two-layer fluid is calculated by a strongly nonlinear method assuming potential flow in each layer. The ship dimensions correspond to those of the Polar ship Fram. The ship draught, b0, is varied in the range 0.25h0-0.9h0 (h0 the upper layer depth). The calculations show that Cdw/(b0/h0)2 depends on the Froude number only, in the range close to critical speed, Fr = U/c0 ˜ 0.875-1.125 (c0 the linear internal long wave speed), irrespective of the ship draught. The function Cdw/(b0/h0)2 attains a maximum at subcritical Froude number depending on the draught. Maximum Cdw/(b0/h0)2 becomes 0.15 for Fr = 0.76, b0/h0 = 0.9, and 0.16 for Fr = 0.74, b0/h0 = 1, where the latter extrapolated value of the dead water resistance coefficient is about 60 times higher than the frictional drag coefficient and relevant for the historical dead water observations. The nonlinear Cdw significantly exceeds linear theory (Fr < 0.85). The ship generated waves have a wave height comparable to the upper layer depth. Calculations of three-dimensional wave patterns at critical speed compare well to available laboratory experiments. Upstream solitary waves are generated in a wave tank of finite width, when the layer depths differ, causing an oscillation of the force. In a wide ocean, a very wide wave system develops at critical speed. The force approaches a constant value for increasing time.

  15. 36 cases of bites by spiders, including the white-tailed spider, Lampona cylindrata.

    PubMed

    White, J; Hirst, D; Hender, E

    1989-04-01

    Thirty-six cases of bites by spiders are reported; in all cases, the spider was identified. No cases resulted in the formation of local ulcers, in necrosis, or in serious systemic symptoms. Eight bites by Lampona cylindrata, the white-tailed spider, caused a mild sting to sharp pain of short duration, itchiness, erythema, local swelling or a lump, and either no systemic symptoms, or anxiety. Five bites by Badumna insignis, the black house-spider, caused local pain, erythema, swelling, and no systemic symptoms, or anxiety, or chest pain and shortness of breath of mild degree and of short duration. The other spiders to be reported as causing bites were Hadronyche adelaidensis, Misgolas andrewsi, Aganippe subtristis, Olios calligaster, Isopeda pessleri, Eriophora sp., Phonognatha graeffei, Holoplatys sp., Breda jovialis, Opisthoncus sp., Lycosa sp. and Achaearanea tepidariorum. PMID:2783216

  16. Pneumoconiosis in Makers of Artificial Grinding Wheels, Including a Case of Caplan's Syndrome*

    PubMed Central

    Posner, E.

    1960-01-01

    Mass miniature radiography surveys in a factory producing artificial grinding wheels detected cases of pneumoconiosis, mostly of the silicotic type. All cases were traced to the department where the so-called “bond” is prepared and mixed with the abrasive grains of carborundum and artificial corundum. This ceramic-vitrified bond, similar in composition to English general earthenware, contained until recently a significant proportion of free silica. The miniature film survey was followed up by an investigation on full-sized films, in which 92% of all workers in the bond department participated. The radiographs were subjected to dual independent viewing and it was found that 66% of the men who had worked in the bond department for more than 10 years showed radiological evidence of pneumoconiosis with a high proportion of progressive massive fibrosis (P.M.F.) Recently the amount of free silica in the ceramic bond has been reduced by the introduction of “frits” in place of powdered flint and part of the factory has been rebuilt and new methods of dust suppression and dust extraction have been introduced. One of the cases presented with the rheumatoid-pneumoconiotic syndrome, first described by Caplan. It is suggested that some of the cases of pneumoconiosis, attributed to carborundum, may be due to the binding materials of artificial grinding wheels. Images PMID:14434374

  17. 30 CFR 250.415 - What must my casing and cementing programs include?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.415 What must my casing and cementing... in Deep Water Wells (as incorporated by reference in § 250.198), if you drill a well in water...

  18. 30 CFR 250.415 - What must my casing and cementing programs include?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.415 What must my casing and cementing... in Deep Water Wells (as incorporated by reference in § 250.198), if you drill a well in water...

  19. 30 CFR 250.415 - What must my casing and cementing programs include?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.415 What must my casing and... in Deep Water Wells (incorporated by reference as specified in § 250.198), if you drill a well...

  20. 30 CFR 250.415 - What must my casing and cementing programs include?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.415 What must my casing and cementing... in Deep Water Wells (as incorporated by reference in § 250.198), if you drill a well in water...

  1. Implementing School Policies That Include Sexual Orientation: A Case Study in School and Community Politics.

    ERIC Educational Resources Information Center

    Macgillivray, Ian K.

    This paper highlights factors that either facilitated or hampered the work of a local Safe Schools Coalition in a Rocky Mountain state in advocating adoption and implementation of their school district's policies that include sexual orientation. Non-discrimination policies that include sexual orientation and gender identity are needed to help stop…

  2. Subcritical crack growth in two titanium alloys.

    NASA Technical Reports Server (NTRS)

    Williams, D. N.

    1973-01-01

    Measurement of subcritical crack growth during static loading of precracked titanium alloys in salt water using samples too thin for plane strain loading to predominate was examined as a method for determining the critical stress intensity for crack propagation in salt water. Significant internal crack growth followed by arrest was found at quite low stress intensities, but crack growth rates were relatively low. Assuming these techniques provided a reliable measurement of the critical stress intensity, the value for annealed Ti-4Al-1.5Mo-0.5V alloy was apparently about 35 ksi-in. to the 1/2 power, while that for annealed Ti-4Al-3Mo-1V was below 45 ksi-in. to the 1/2 power. Crack growth was also observed in tests conducted in both alloys in an air environment. At 65 ksi-in. to the 1/2 power, the extent of crack growth was greater in air than in salt water. Ti-4Al-3Mo-1V showed arrested crack growth in air at a stress intensity of 45 ksi-in. to the 1/2 power.

  3. Safety features of subcritical fluid fueled systems

    SciTech Connect

    Bell, Charles R.

    1995-09-15

    Accelerator-driven transmutation technology has been under study at Los Alamos for several years for application to nuclear waste treatment, tritium production, energy generation, and recently, to the disposition of excess weapons plutonium. Studies and evaluations performed to date at Los Alamos have led to a current focus on a fluid-fuel, fission system operating in a neutron source-supported subcritical mode, using molten salt reactor technology and accelerator-driven proton-neutron spallation. In this paper, the safety features and characteristics of such systems are explored from the perspective of the fundamental nuclear safety objectives that any reactor-type system should address. This exploration is qualitative in nature and uses current vintage solid-fueled reactors as a baseline for comparison. Based on the safety perspectives presented, such systems should be capable of meeting the fundamental nuclear safety objectives. In addition, they should be able to provide the safety robustness desired for advanced reactors. However, the manner in which safety objectives and robustness are achieved is very different from that associated with conventional reactors. Also, there are a number of safety design and operational challenges that will have to be addressed for the safety potential of such systems to be credible.

  4. Safety features of subcritical fluid fueled systems

    SciTech Connect

    Bell, C.R.

    1994-09-01

    Accelerator-driven transmutation technology has been under study at Los Alamos for several years for application to nuclear waste treatment, tritium production, energy generation, and recently, to the disposition of excess weapons plutonium. Studies and evaluations performed to date at Los Alamos have led to a current focus on a fluid-fuel, fission system operating in a neutron source-supported subcritical mode, using molten salt reactor technology and accelerator-driven proton-neutron spallation. In this paper, the safety features and characteristics of such systems are explored from the perspective of the fundamental nuclear safety objectives that any reactor-type system should address. This exploration is qualitative in nature and uses current vintage solid-fueled reactors as a baseline for comparison. Based on the safety perspectives presented, such systems should be capable of meeting the fundamental nuclear safety objectives. In addition, they should be able to provide the safety robustness desired for advanced reactors. However, the manner in which safety objectives and robustness are achieved in very different from that associated with conventional reactors. Also, there are a number of safety design and operational challenges that will have to be addressed for the safety potential of such systems to be credible.

  5. Subcritical transmutation of spent nuclear fuel

    NASA Astrophysics Data System (ADS)

    Sommer, Christopher M.

    2011-07-01

    A series of fuel cycle simulations were performed using CEA's reactor physics code ERANOS 2.0 to analyze the transmutation performance of the Subcritical Advanced Burner Reactor (SABR). SABR is a fusion-fission hybrid reactor that combines the leading sodium cooled fast reactor technology with the leading tokamak plasma technology based on ITER physics. Two general fuel cycles were considered for the SABR system. The first fuel cycle is one in which all of the transuranics from light water reactors are burned in SABR. The second fuel cycle is a minor actinide burning fuel cycle in which all of the minor actinides and some of the plutonium produced in light water reactors are burned in SABR, with the excess plutonium being set aside for starting up fast reactors in the future. The minor actinide burning fuel cycle is being considered in European Scenario Studies. The fuel cycles were evaluated on the basis of TRU/MA transmutation rate, power profile, accumulated radiation damage, and decay heat to the repository. Each of the fuel cycles are compared against each other, and the minor actinide burning fuel cycles are compared against the EFIT transmutation system, and a low conversion ratio fast reactor.

  6. Experimental study of elliptical jet from supercritical to subcritical conditions using planar laser induced fluorescence

    SciTech Connect

    Muthukumaran, C. K.; Vaidyanathan, Aravind

    2015-03-15

    The study of fluid jet dynamics at supercritical conditions involves strong coupling between fluid dynamic and thermodynamic phenomena. Beyond the critical point, the liquid-vapor coexistence ceases to exist, and the fluid exists as a single phase known as supercritical fluid with its properties that are entirely different from liquids and gases. At the critical point, the liquids do not possess surface tension and latent heat of evaporation. Around the critical point, the fluid undergoes large changes in density and possesses thermodynamic anomaly like enhancement in thermal conductivity and specific heat. In the present work, the transition of the supercritical and near-critical elliptical jet into subcritical as well as supercritical environment is investigated experimentally with nitrogen and helium as the surrounding environment. Under atmospheric condition, a liquid jet injected from the elliptical orifice exhibits axis switching phenomena. As the injection temperature increases, the axis switching length also increases. Beyond the critical temperature, the axis switching is not observed. The investigation also revealed that pressure plays a major role in determining the thermodynamic transition of the elliptical jet only for the case of supercritical jet injected into subcritical chamber conditions. At larger pressures, the supercritical jet undergoes disintegration and formation of droplets in the subcritical environment is observed. However, for supercritical jet injection into supercritical environment, the gas-gas like mixing behavior is observed.

  7. Hydrolysis of polycarbonate in sub-critical water in fused silica capillary reactor with in situ Raman spectroscopy

    USGS Publications Warehouse

    Pan, Z.; Chou, I.-Ming; Burruss, R.C.

    2009-01-01

    The advantages of using fused silica capillary reactor (FSCR) instead of conventional autoclave for studying chemical reactions at elevated pressure and temperature conditions were demonstrated in this study, including the allowance for visual observation under a microscope and in situ Raman spectroscopic characterization of polycarbonate and coexisting phases during hydrolysis in subcritical water. ?? 2009 The Royal Society of Chemistry.

  8. Local heat transfer measurement with liquid crystals on rotating surfaces including non-axisymmetric cases

    NASA Technical Reports Server (NTRS)

    Metzger, D. E.; Kim, Y. K.

    1993-01-01

    An overview and summary of test methods and results are given for the problem of measuring local heat transfer on rotating surfaces that model gas turbine engine disks. Disk cavity situations generically similar to those encountered in the high pressure stage disk cooling are considered, with cooling air supplied both at or near the wheel centerline as well as through single or multiple jets impinging outboard on the wheel near the blade attachment region. In some situations provision has been made for ingestion into the disk-cavity from the gas path region radially outboard of the disk. Local heat transfer rates in all cases are determined from the color display from a thin coating of encapsulated liquid crystals sprayed onto the disk, in conjunction with use of a video camera and computer vision system. For cases with axisymmetric disk surfaces, the coated surfaces are illuminated and viewed continuously, and detailed radial distributions of local Nusselt number are obtained. For non-axisymmetric disk surfaces, such as encountered in the vicinity of bolt heads, the disk is illuminated with stroboscopic light, and a method has been developed and used to synchronize the computer frame grabber with the illumination.

  9. A case of cap polyposis remission by betamethasone enema after antibiotics therapy including Helicobacter pylori eradication.

    PubMed

    Suzuki, Hideo; Sato, Masashi; Akutsu, Daisuke; Sugiyama, Hiroaki; Sato, Taiki; Mizokami, Yuji

    2014-06-01

    We report the case of a 58-year-old woman who was referred to our hospital due to frequent bloody mucus diarrhea. She was diagnosed with cap polyposis based on typical endoscopic and histological findings. Colonoscopy revealed multiple, reddish, mucus-capped polypoid lesions from the rectum to the sigmoid colon. A pathological examination revealed that the polyps were covered by erosive and inflamed granulation tissue with decreased crypt cells. Laboratory data indicated positive values for Helicobacter pylori immunoglobulin G antibody and hypoproteinemia. Metronidazole, H. pylori eradication, and levofloxacin therapies were not effective; however, the subsequent administration of betamethasone enema dramatically improved the clinical symptoms and endoscopic findings. The hypoproteinemia was normalized after the therapy. The dose of the betamethasone enema was tapered gradually, and no recurrence was observed 6 months after discontinuation of the treatment. This case suggests that betamethasone enema may be considered as the second treatment choice for cap polyposis patients after H. pylori eradication, metronidazole or levofloxacin therapy. PMID:24949613

  10. Xp11.22 Microduplications Including HUWE1: Case Report and Literature Review.

    PubMed

    Orivoli, Sonia; Pavlidis, Elena; Cantalupo, Gaetano; Pezzella, Marianna; Zara, Federico; Garavelli, Livia; Pisani, Francesco; Piccolo, Benedetta

    2016-01-01

    Xp11.22 microduplications have been reported in different patients with X-linked intellectual disability. Comparing the duplicated segments, a minimum region of overlap has been identified. Within this region, only one gene, the HUWE1 gene, coding the E3 ubiquitin protein ligase, turned out to be duplicated in all previously described patients. We provide a review of the literature on this topic, making a comparison not only of genetic aspects, but also of clinical, neurophysiological, and neuroradiological findings. Furthermore, we describe the phenotypic and molecular characterization of a case of intellectual disability in a child carrying one of the smallest Xp11.22 microduplications reported, involving the whole sequence of HUWE1 gene. Unlike previously described cases, our patient's neuroimaging showed abnormal findings; he also experienced one seizure and showed interictal electroencephalogram (EEG) epileptiform abnormalities. Given the fact that HUWE1 duplications and mutations have previously been described in several patients with X-linked cognitive impairment, our findings support the hypothesis that HUWE1 gene might be implicate in the pathogenesis of intellectual disability. Nevertheless, further investigations and a more detailed examination of patients' clinical history are needed to clear up other eventual genotype-phenotype correlations, such as the presence of epilepsy/epileptiform EEG abnormalities. PMID:26587761

  11. Ready for School: The Case for Including Babies and Toddlers as We Expand Preschool Opportunities.

    ERIC Educational Resources Information Center

    Wilen, Julie Rubins

    While the notion of starting education early with children has gained momentum in the public's mind, our public policies and investments still do not reflect society's increasing knowledge of how the human brain grows and how very early experiences beginning at birth affect a child's future. Arguing that if policymakers fail to include the needs…

  12. The Case for Expanding Standards for Teacher Evaluation to Include an Instructional Supervision Perspective

    ERIC Educational Resources Information Center

    Holland, Patricia

    2005-01-01

    Despite the concerns of scholars in the field of instructional supervision, teacher evaluations continue to emphasize bureaucratic accountability and standardization. This article presents an argument for extending the Joint Committee on Standards' Personnel Evaluation Standards to include standards related to the practice of supervision. The…

  13. Dubowitz syndrome: review of 141 cases including 36 previously unreported patients.

    PubMed

    Tsukahara, M; Opitz, J M

    1996-05-01

    We review clinical information on 141 individuals with Dubowitz syndrome, 105 reported since 1965, and 36 previously unreported. We define the Dubowitz syndrome phenotype on the basis of clinical descriptions. The facial appearance is characteristic and present in most patients with Dubowitz syndrome. The phenotypic spectrum is quite variable and ranges from normal growth and head circumference with mild psychomotor retardation and lack of eczema to a condition of severe growth retardation, mental retardation, microcephaly, and eczema. Overall, the condition may involve the cutaneous, ocular, dental, digestive, musculoskeletal, urogenital, cardiovascular, neurological, hematological, and immune systems. Characteristic behavior patterns which have not been cited previously are present in our cases; most patients are hyperactive, shy, hate crowds, and like music, rhythm, and vibrations from music speakers, tape recorders, or transmitted through floors. Dubowitz syndrome is an autosomal recessive disorder with possibly increased frequency of parental consanguinity. Heterogeneity cannot be excluded at this time. PMID:8723121

  14. Including the introduction of exotic species in life cycle impact assessment: the case of inland shipping.

    PubMed

    Hanafiah, Marlia M; Leuven, Rob S E W; Sommerwerk, Nike; Tockner, Klement; Huijbregts, Mark A J

    2013-12-17

    While the ecological impact of anthropogenically introduced exotic species is considered a major threat for biodiversity and ecosystems functioning, it is generally not accounted for in the environmental life cycle assessment (LCA) of products. In this article, we propose a framework that includes exotic species introduction in an LCA context. We derived characterization factors for exotic fish species introduction related to the transport of goods across the Rhine-Main-Danube canal. These characterization factors are expressed as the potentially disappeared fraction (PDF) of native freshwater fish species in the rivers Rhine and Danube integrated over space and time per amount of goods transported (PDF·m(3)·yr·kg(-1)). Furthermore, we quantified the relative importance of exotic fish species introduction compared to other anthropogenic stressors in the freshwater environment (i.e., eutrophication, ecotoxicity, greenhouse gases, and water consumption) for transport of goods through the Rhine-Main-Danube waterway. We found that the introduction of exotic fish species contributed to 70-85% of the total freshwater ecosystem impact, depending on the distance that goods were transported. Our analysis showed that it is relevant and feasible to include the introduction of exotic species in an LCA framework. The proposed framework can be further extended by including the impacts of other exotic species groups, types of water bodies and pathways for introduction. PMID:24251685

  15. Subcritical and supercritical fuel injection and mixing in single and binary species systems

    NASA Astrophysics Data System (ADS)

    Roy, Arnab

    Subcritical and supercritical fluid injection using a single round injector into a quiescent atmosphere comprising single and binary species was investigated using optical diagnostics. Different disintegration and mixing modes are expected for the two cases. In the binary species case, the atmosphere comprised an inert gas of a different composition than that of the injected fluid. In single species case, the atmosphere consisted of the same species as that of the injected fluid. Density values were quantified and density gradient profiles were inferred from the experimental data. A novel method was applied for the detection of detailed structures throughout the entire jet center plane. Various combinations of injectant and chamber conditions were tested and a wide range of density ratios were covered. The subcritical cases demonstrated the importance of surface tension and inertial forces, while the supercritical cases showed no signs of surface tension and, in most situations, resembled the mixing characteristics of a gaseous jet injected into a gaseous environment. A comparison between the single and binary species systems has also been provided. A detailed laser calibration procedure was undertaken to account for the laser absorption through the gas and liquid phases and for fluorescence in the non-linear excitation regime for high laser pulse energy. Core lengths were measured for binary species cases and correlated with visualization results. An eigenvalue approach was taken to determine the location of maximum gradients for determining the core length. Jet divergence angles were also calculated and were found to increase with chamber-to-injectant density ratio for both systems. A model was proposed for the spreading angle dependence on density ratio for both single and binary species systems and was compared to existing theoretical studies and experimental work. Finally, a linear stability analysis was performed for the jet injected into both subcritical and

  16. Subcritical scattering from buried elastic shells.

    PubMed

    Lucifredi, Irena; Schmidt, Henrik

    2006-12-01

    Buried objects have been largely undetectable by traditional high-frequency sonars due to their insignificant bottom penetration. Further, even a high grazing angle sonar approach is vastly limited by the coverage rate dictated by the finite water depth, making the detection and classification of buried objects using low frequency, subcritical sonar an interesting alternative. On the other hand, such a concept would require classification clues different from the traditional high-resolution imaging and shadows to maintain low false alarm rates. A potential alternative, even for buried targets, is classification based on the acoustic signatures of man-made elastic targets. However, the elastic responses of buried and proud targets are significantly different. The objective of this work is to identify, analyze, and explain some of the effects of the sediment and the proximity of the seabed interface on the scattering of sound from completely and partially buried elastic shells. The analysis was performed using focused array processing of data from the GOATS98 experiment carried out jointly by MIT and SACLANTCEN, and a new hybrid modeling capability combining a virtual source-or wave-field superposition-approach with an exact spectral integral representation of the Green's functions for a stratified ocean waveguide, incorporating all multiple scattering between the object and the seabed. Among the principal results is the demonstration of the significant role of structural circumferential waves in converting incident, evanescent waves into backscattered body waves, emanating to the receivers at supercritical grazing angles, in effect making the target appear closer to the sonar than predicted by traditional ray theory. PMID:17225387

  17. Environmental impact assessment including indirect effects--a case study using input-output analysis

    SciTech Connect

    Lenzen, Manfred; Murray, Shauna A.; Korte, Britta; Dey, Christopher J

    2003-05-01

    Environmental impact assessment (EIA) is a process covered by several international standards, dictating that as many environmental aspects as possible should be identified in a project appraisal. While the ISO 14011 standard stipulates a broad-ranging study, off-site, indirect impacts are not specifically required for an Environmental Impact Statement (EIS). The reasons for this may relate to the perceived difficulty of measuring off-site impacts, or the assumption that these are a relatively insignificant component of the total impact. In this work, we describe a method that uses input-output analysis to calculate the indirect effects of a development proposal in terms of several indicator variables. The results of our case study of a Second Sydney Airport show that the total impacts are considerably higher than the on-site impacts for the indicators land disturbance, greenhouse gas emissions, water use, emissions of NO{sub x} and SO{sub 2}, and employment. We conclude that employing input-output analysis enhances conventional EIA, as it allows for national and international effects to be taken into account in the decision-making process.

  18. Monitoring active volcanoes and mitigating volcanic hazards: the case for including simple approaches

    NASA Astrophysics Data System (ADS)

    Stoiber, Richard E.; Williams, Stanley N.

    1990-07-01

    Simple approaches to problems brought about eruptions and their ensuing hazardous effects should be advocated and used by volcanologists while awaiting more sophisticated remedies. The expedients we advocate have all or many of the following attributes: only locally available materials are required; no extensive training of operators or installation is necessary; they are affordable and do not require foreign aid or exports; they are often labor intensive and are sustainable without outside assistance. Where appropriate, the involvement of local residents is advocated. Examples of simple expedients which can be used in forecasting or mitigating the effects of crises emphasize the relative ease and the less elaborate requirements with which simple approaches can be activated. Emphasis is on visual observations often by untrained observers, simple meteorogical measurements, observations of water level in lakes, temperature and chemistry of springs and fumaroles, new springs and collapse areas and observations of volcanic plumes. Simple methods are suggested which can be applied to mitigating damage from mudflows, nuées ardentes, tephra falls and gas discharge. A review in hindsight at Ruiz includes the use of both chemical indicators and simple mudflow alarms. Simple expedients are sufficiently effective that any expert volcanologist called to aid in a crisis must include them in the package of advice offered. Simple approaches are a critical and logical complement to highly technical solutions to hazardous situations.

  19. Reaction kinetics of cellulose hydrolysis in subcritical and supercritical water

    NASA Astrophysics Data System (ADS)

    Olanrewaju, Kazeem Bode

    The uncertainties in the continuous supply of fossil fuels from the crisis-ridden oil-rich region of the world is fast shifting focus on the need to utilize cellulosic biomass and develop more efficient technologies for its conversion to fuels and chemicals. One such technology is the rapid degradation of cellulose in supercritical water without the need for an enzyme or inorganic catalyst such as acid. This project focused on the study of reaction kinetics of cellulose hydrolysis in subcritical and supercritical water. Cellulose reactions at hydrothermal conditions can proceed via the homogeneous route involving dissolution and hydrolysis or the heterogeneous path of surface hydrolysis. The work is divided into three main parts. First, the detailed kinetic analysis of cellulose reactions in micro- and tubular reactors was conducted. Reaction kinetics models were applied, and kinetics parameters at both subcritical and supercritical conditions were evaluated. The second major task was the evaluation of yields of water soluble hydrolysates obtained from the hydrolysis of cellulose and starch in hydrothermal reactors. Lastly, changes in molecular weight distribution due to hydrothermolytic degradation of cellulose were investigated. These changes were also simulated based on different modes of scission, and the pattern generated from simulation was compared with the distribution pattern from experiments. For a better understanding of the reaction kinetics of cellulose in subcritical and supercritical water, a series of reactions was conducted in the microreactor. Hydrolysis of cellulose was performed at subcritical temperatures ranging from 270 to 340 °C (tau = 0.40--0.88 s). For the dissolution of cellulose, the reaction was conducted at supercritical temperatures ranging from 375 to 395 °C (tau = 0.27--0.44 s). The operating pressure for the reactions at both subcritical and supercritical conditions was 5000 psig. The results show that the rate-limiting step in

  20. Residential sidewall insulation case histories, including experiences and problems in the field application of loose fill

    SciTech Connect

    Infante, L.J.; Aller, P.F.; Fay, R.E.

    1983-01-01

    An unbonded fiberglass loose-fill insulation was selected for this sidewall application study. The insert tube technique is described and the parameters that affect pneumatic application of the product are identified. The initial evaluation was conducted in the laboratory and included density and thermal testing. The laboratory results were then utilized in field studies. Ten homes with no sidewall insulation were retrofitted. Thermographic scans of sidewalls before and after retrofit confirmed the predicted reductions in heat loss based on calculation techniques given in the ASHRAE Handbook of Fundamentals. The improvement was further confirmed by comparing utility bills. Typical problems that occur while preparing a house for sidewall retrofit are discussed. The simple payback for typical houses is presented. Good correlation is shown between laboratory test results and field performance. Test data indicate that the application procedure used gave an effective R-value per product claim.

  1. Skin symptoms in four ectodermal dysplasia syndromes including two case reports of Rapp-Hodgkin-Syndrome.

    PubMed

    Knaudt, Björn; Volz, Thomas; Krug, Markus; Burgdorf, Walter; Röcken, Martin; Berneburg, Mark

    2012-01-01

    The skin, hair and nail changes in four distinct ectodermal dysplasia syndromes are compared and reviewed. These syndromes comprise Christ-Siemens-Touraine syndrome; ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome; ankyloblepharon-ectodermal defects-cleft lip/palate syndrome and Rapp-Hodgkin syndrome. A comprehensive overview of the dermatological signs and symptoms in these syndromes was generated from the database of the Ectodermal Dysplasia Network Germany, the clinical findings in the patients seen in our department and an extensive review of the literature. The findings included abnormalities of skin, sweating, hair and nails. These clinical findings are discussed in relation to the underlying molecular defects known to play a role in these four ectodermal dysplasia syndromes. PMID:22759387

  2. Sediment budget including the role of floodplains: the case of Lake Tana Basin (Ethiopia)

    NASA Astrophysics Data System (ADS)

    Lemma, Hanibal; Admasu, Teshager; Dessie, Mekete; Fentie, Derbew; Poesen, Jean; Lanckriet, Sil; Adgo, Enyew; Nyssen, Jan

    2016-04-01

    Based on the collection of a large new dataset, we quantify the sediment 1) mobilized on the hillslopes surrounding Lake Tana (Ethiopia), 2) stored on the floodplains, 3) transported into the lake, 4) deposited in the lake and 5) delivered out of the lake so as to establish a sediment budget. In 2012 and 2013, suspended sediment concentration (SSC) and discharge measurements were made at 13 monitoring stations, including two lake outlets. 4635 SSC samples were collected and sediment rating curves that account for land cover conditions and rainfall seasonality were established for the 11 river stations, and mean monthly SSC was calculated for the outlets. Effects of the floodplain on rivers' sediment yield (SY) were investigated using the measurements at the upper and lower stations of Gilgel Abay, Gumara, Megech and Rib Rivers. SY from ungauged rivers was assessed using a model that includes catchment area and rainfall, whereas bedload and direct sediment input from lake shores were estimated. As a result, the gross annual SY from both gauged and ungauged rivers, bedload and lake shores was ca. 3.14 million tons, dominantly from Gilgel Abay and Gumara Rivers. The 0.48 million tons sedimentation in floodplains indicate that the floodplains serve as sediment sink. Moreover, annually about 1.09 million tons of sediment leaves the lake through the two outlets. Annual deposition in Lake Tana was about 1.56 million tons with a trapping efficiency of 60%. Furthermore, SSC and SY are generally higher at the beginning of the rainy season because soil in cultivated fields is bare and loose due to frequent ploughing and seedbed preparation. Later on in the season, increased crop and vegetation cover lead to a decrease in sediment supplies. Based on the established sediment budget and its calculated components, one can conclude that the expected lifetime of Lake Tana (20,396 years) is longer than what was anticipated in earlier studies.

  3. A case for integrity: gains from including more than animal welfare in animal ethics committee deliberations.

    PubMed

    Röcklinsberg, H; Gamborg, C; Gjerris, M

    2014-01-01

    From January 2013, a new EU Directive 63/2010/EU requires that research using animals must undergo a harm-benefit analysis, which takes ethical considerations into account (Art. 38 (2) d) - a so-called 'project authorization' (Art. 36). A competent authority in each member state has to ensure that no project is carried out without such a project validation process, but often delegates the actual assessment to an animal ethics committee (AEC) or its equivalent. The core task of the AEC is to formulate a justifiable balance between the animals' suffering caused by research and the potential human benefit. AECs traditionally focus on animal welfare issues, but according to the new directive other public concerns must also be taken into account. Taking the new EU Directive as a point of departure, the central aim of this paper is to discuss the evaluation process in relation to animal welfare and animal ethics through the concept of animal integrity. A further aim is to elaborate on possible improvements to project evaluation by considering animal integrity. We argue that concepts like animal integrity are often left out of project authorization processes within AECs, because animal ethics is often interpreted narrowly to include only certain aspects of animal welfare. Firstly, we describe the task of an AEC and discuss what has typically been regarded as ethically relevant in the assessment process. Secondly, we categorize four notions of integrity found in the literature to show the complexity of the concept and furthermore to indicate its strengths. Thirdly, we discuss how certain interpretations of integrity can be included in AEC assessments to encapsulate wider ethical concerns and, perhaps even increase the democratic legitimacy of AECs. PMID:24367033

  4. Granulocyte-colony stimulating factor-producing gallbladder carcinoma-include analysis all case reports: A case report

    PubMed Central

    Izumo, Wataru; Furukawa, Kenji; Katsuragawa, Hideo; Tezuka, Toru; Furukawa, Tatsuya; Hataji, Kenichirou; Komatsu, Akio; Shigematsu, Kyousuke; Yamamoto, Masakazu

    2016-01-01

    Introduction It is extremely rare for gallbladder carcinoma to produce granulocyte-colony stimulating factor (G-CSF) and such tumors have a poor prognosis. Presentation of case A 67-year-old man was admitted with continuous fever. Laboratory tests showed a leukocyte count of 27,980/μL, serum C-reactive protein (CRP) of 9.2 mg/dL and serum G-CSF of 225 pg/mL. Imaging revealed an irregular gallbladder mass about 90 mm in diameter with peripheral enhancement that also involved the liver and transverse colon. G-CSF producing gallbladder carcinoma was diagnosed. We performed cholecystectomy, partial resection of segments 4 and 5 of the liver, partial resection of the transverse colon, and gastrostomy. Histopathological examination showed gallbladder carcinoma (pT3, pN0, M0, G2, and pStage IIIA by the UICC classification, version 7). On immunohistochemical staining, tumor cells were positive for G-CSF. The leukocyte count was normalized postoperatively and fever subsided immediately after surgery. Two months later, the leukocyte count rose to 56,820/μL and metastases to the liver and lymph nodes were detected by CT. Chemotherapy (gemcitabine plus cisplatin) was started and the leukocyte count was normalized after the first course. The patient has continued chemotherapy and has survived for 16 months postoperatively. Discussion G-CSF producing gallbladder carcinoma has a poor prognosis and most patients die within 12 months of starting therapy. It is rare for patients with recurrence to survive for 16 months after surgery, as in the present case. Conclusion Multidisciplinary therapy (surgery and chemotherapy) may prolong the survival of patients with G-CSF producing gallbladder carcinoma, especially those with recurrence. PMID:26945490

  5. A fuel for sub-critical fast reactor

    NASA Astrophysics Data System (ADS)

    Moiseenko, V. E.; Chernitskiy, S. V.; Ågren, O.; Noack, K.

    2012-06-01

    Along with the problem of the nuclear waste transmutation, the problem of minimization of waste production is of current interest. It is not possible to eliminate production of waste at a nuclear power plant, but, as is shown in this report, it is in principle possible to arrange a fuel composition with no net production of transuranic elements. The idea is to find the transuranic elements composition to which the depleted uranium is continuously supplied during frequent reprocessing, and amount of each other transuranic fuel component remains unchanged in time. For each transuranic component, the balance is achieved by equating burnup and production rates. The production is due to neutron capture by the neighboring lighter isotope and subsequent beta-decay. The burnup includes fission, neutron capture and decays. For the calculations a simplified burnup model which accounts for 9 isotopes of uranium, neptunium, plutonium and americium is used. The calculated fuel composition consists mainly of uranium with minority of plutonium isotopes. Such a fuel, after usage in a sub-critical fast reactor, should be reprocessed. The fission product content increases during burnup, representing a net production of waste, while the transuranic elements and 238U should be recycled into a new fuel. For such a fuel cycle, the net consumption is only for 238U, and the net waste production is just fission products.

  6. A fuel for sub-critical fast reactor

    SciTech Connect

    Moiseenko, V. E.; Chernitskiy, S. V.; Agren, O.; Noack, K.

    2012-06-19

    Along with the problem of the nuclear waste transmutation, the problem of minimization of waste production is of current interest. It is not possible to eliminate production of waste at a nuclear power plant, but, as is shown in this report, it is in principle possible to arrange a fuel composition with no net production of transuranic elements. The idea is to find the transuranic elements composition to which the depleted uranium is continuously supplied during frequent reprocessing, and amount of each other transuranic fuel component remains unchanged in time. For each transuranic component, the balance is achieved by equating burnup and production rates. The production is due to neutron capture by the neighboring lighter isotope and subsequent beta-decay. The burnup includes fission, neutron capture and decays. For the calculations a simplified burnup model which accounts for 9 isotopes of uranium, neptunium, plutonium and americium is used. The calculated fuel composition consists mainly of uranium with minority of plutonium isotopes. Such a fuel, after usage in a sub-critical fast reactor, should be reprocessed. The fission product content increases during burnup, representing a net production of waste, while the transuranic elements and {sup 238}U should be recycled into a new fuel. For such a fuel cycle, the net consumption is only for 238U, and the net waste production is just fission products.

  7. Experiences integrating productivity, pollution prevention, and energy conservation including case studies

    SciTech Connect

    Kasten, D.J.; Muller, M.R.; Barnish, T.J.

    1997-07-01

    , or even space to expand operations. An intimate knowledge of a corporations' burden, market share, and financial stability is necessary in order for the assessment team to gain the confidence of management; failure to do so can be disastrous. Excessive movement, redundant inspections, scheduling issues, and floor layout are critical issues, and ones that are sometimes impossible to evaluate during a short visit to a plant. Before an energy audit is made, much information must be gathered, such as tax rates and purchasing policies (including acceptable defect rates of the raw materials from suppliers). These issues are forcing the one-dimensional energy expert to expand into previously unchartered territories. This paper will attempt to illustrate some generic necessities, but also use actual experiences of the Office of Industrial Productivity and Energy Assessment team at Rutgers University in three facilities to highlight the industrial triage method of presenting the client with an integrated package of analysis of the efficiency of their production facility and methods.

  8. Subcritical water extraction of antioxidant compounds from rosemary plants.

    PubMed

    Ibañez, Elena; Kubátová, Alena; Señoráns, F Javier; Cavero, Sofia; Reglero, Guillermo; Hawthorne, Steven B

    2003-01-15

    Subcritical water extraction at several temperatures ranging from 25 to 200 degrees C has been studied to selectively extract antioxidant compounds from rosemary leaves. An exhaustive characterization of the fractions obtained using subcritical water at different temperatures has been carried out by LC-MS, and the antioxidant activities of the extracts have been measured by a free radical method (DPPH). Results indicate high selectivity of the subcritical water toward the most active compounds of rosemary such as carnosol, rosmanol, carnosic acid, methyl carnosate, and some flavonoids such as cirsimaritin and genkwanin. The antioxidant activity of the fractions obtained by extraction at different water temperatures was very high, with values around 11.3 microg/mL, comparable to those achieved by SFE of rosemary leaves. A study of the effect of the temperature on the extraction efficiency of the most typical rosemary antioxidant compounds has been performed. PMID:12517098

  9. Nonlinear excitation of subcritical fast ion-driven modes

    NASA Astrophysics Data System (ADS)

    Lesur, M.; Itoh, K.; Ido, T.; Itoh, S.-I.; Kosuga, Y.; Sasaki, M.; Inagaki, S.; Osakabe, M.; Ogawa, K.; Shimizu, A.; Ida, K.; the LHD experiment group

    2016-05-01

    In collisionless plasma, it is known that linearly stable modes can be destabilized (subcritically) by the presence of structures in phase-space. The growth of such structures is a nonlinear, kinetic mechanism, which provides a channel for free-energy extraction, different from conventional inverse Landau damping. However, such nonlinear growth requires the presence of a seed structure with a relatively large threshold in amplitude. We demonstrate that, in the presence of another, linearly unstable (supercritical) mode, wave–wave coupling can provide a seed, which can lead to subcritical instability by either one of two mechanisms. Both mechanisms hinge on a collaboration between fluid nonlinearity and kinetic nonlinearity. If collisional velocity diffusion is low enough, the seed provided by the supercritical mode overcomes the threshold for nonlinear growth of phase-space structure. Then, the supercritical mode triggers the conventional subcritical instability. If collisional velocity diffusion is too large, the seed is significantly below the threshold, but can still grow by a sustained collaboration between fluid and kinetic nonlinearities. Both of these subcritical instabilities can be triggered, even when the frequency of the supercritical mode is rapidly sweeping. These results were obtained by modeling the subcritical mode kinetically, and the impact of the supercritical mode by simple wave–wave coupling equations. This model is applied to bursty onset of geodesic acoustic modes in an LHD experiment. The model recovers several key features such as relative amplitude, timescales, and phase relations. It suggests that the strongest bursts are subcritical instabilities, with sustained collaboration between fluid and kinetic nonlinearities.

  10. 30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What information must I include in the âWorst case discharge scenarioâ appendix? 254.26 Section 254.26 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE...

  11. A Case Study of Tack Tiles[R] Literacy Instruction for a Student with Multiple Disabilities Including Congenital Blindness

    ERIC Educational Resources Information Center

    Klenk, Jessicia A.; Pufpaff, Lisa A.

    2011-01-01

    Research on literacy instruction for students with multiple disabilities is limited. Empirical research on braille instruction for students with multiple disabilities that include congenital blindness is virtually nonexistent. This case study offers initial insight into possible methods of early braille literacy instruction for a student with…

  12. Mammary analogue secretory carcinoma of salivary glands: a clinicopathologic and molecular study including 2 cases harboring ETV6-X fusion.

    PubMed

    Ito, Yohei; Ishibashi, Kenichiro; Masaki, Ayako; Fujii, Kana; Fujiyoshi, Yukio; Hattori, Hideo; Kawakita, Daisuke; Matsumoto, Manabu; Miyabe, Satoru; Shimozato, Kazuo; Nagao, Toshitaka; Inagaki, Hiroshi

    2015-05-01

    Mammary analogue secretory carcinoma (MASC) is a recently described low-grade carcinoma with morphologic and genetic similarity, including ETV6-NTRK3 fusion, to secretory carcinoma of the breast. ETV6 is frequently involved in other epithelial and nonepithelial tumors, and many fusion partners of ETV6 have been reported. In the present study, 14 Japanese MASC cases were clinicopathologically and molecularly analyzed. The median age of the patients was 39 years, and the male:female ratio was 6:8. All cases showed histopathologic findings compatible with those previously described for MASC and harbored an ETV6 split as visualized by fluorescence in situ hybridization. Two cases showed thick fibrous septa and invasive features including vascular or perineural tumor involvement, findings that are rare in MASC. In addition, in these 2 cases, non-NTRK3 genes appeared to fuse with ETV6 (ETV6-X fusion). NTRK1 and NTRK2, both members of the NTRK family, were not involved. Of the 14 MASC cases, the ETV6-NTRK3 fusion transcript was positive in 6 cases, and the relative expression level of the ETV6-NTRK3 fusion transcript was variable, ranging from 1 to 5.8. Results of the present study of MASC suggest that (1) ETV6 occasionally fuses with unknown non-NTRK3 genes, (2) ETV6-X cases might have an invasive histology, (3) for molecular diagnosis of MASC, fluorescence in situ hybridization to detect ETV6 splits is the method of choice, and (4) the expression level of the ETV6-NTRK3 fusion transcript is considerably variable. These findings provide a novel insight into the oncogenesis, histopathology, diagnosis, treatment, and prognosis of this newly recognized carcinoma. PMID:25651470

  13. Vortex induced vibrations of a square cylinder at subcritical Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Singh, S. P.; Biswas, G.

    2013-08-01

    Vortex induced vibration (VIV) of an elastically mounted square cylinder of low non-dimensional mass is simulated at subcritical Reynolds numbers (Re), i.e.,Re≤50. The cylinder is allowed to vibrate in the transverse direction to the incoming flow. Four cases are considered for understanding the behavior of VIV of the square cylinder at subcritical Re. In the first case, the non-dimensional frequency varies as 3.1875/Re. In the second case, the non-dimensional frequency is kept constant at 0.1333. In both the cases, Re is varied. In third and fourth cases, studies are conducted for Re=25, 30 and 35, and Re=80, respectively. In the third and fourth cases, the non-dimensional velocity, U*, is varied. It is found that maximum transverse displacement is approximately 0.15D when the non-dimensional frequency, Fn, varies with Re. The maximum transverse displacement is 0.25D when the non-dimensional frequency is constant. For the first case, VIV starts at Re as low as 23.9 and it ceases at Re˜33.5. In all these cases, it is observed that the phase difference between the lift coefficient and the transverse displacement depends upon non-dimensional mass, Re, and non-dimensional velocity. In all the cases, the lock-in phenomenon is observed. In the fourth case of supercritical Re, hysteresis is also observed and it is seen that its extent depends upon non-dimensional mass. Stabilized finite-element space-time formulations (SUPG and PSPG) are utilized to solve the two-dimensional incompressible Navier-Stokes equations together with the equations of motion of the body.

  14. Neutronics for critical fission reactors and subcritical fission in hybrids

    SciTech Connect

    Salvatores, Massimo

    2012-06-19

    The requirements of future innovative nuclear fuel cycles will focus on safety, sustainability and radioactive waste minimization. Critical fast neutron reactors and sub-critical, external source driven systems (accelerator driven and fusion-fission hybrids) have a potential role to meet these requirements in view of their physics characteristics. This paper provides a short introduction to these features.

  15. Nonlinear Excitation of Subcritical Instabilities in a Toroidal Plasma

    NASA Astrophysics Data System (ADS)

    Lesur, M.; Itoh, K.; Ido, T.; Osakabe, M.; Ogawa, K.; Shimizu, A.; Sasaki, M.; Ida, K.; Inagaki, S.; Itoh, S.-I.; LHD Experiment Group

    2016-01-01

    In a collisionless plasma, it is known that linearly stable modes can be destabilized (subcritically) by the presence of structures in phase space. However, nonlinear growth requires the presence of a seed structure with a relatively large threshold in amplitude. We demonstrate that, in the presence of another, linearly unstable (supercritical) mode, wave-wave coupling can provide a seed, which is significantly below the threshold, but can still grow by (and only by) the collaboration of fluid and kinetic nonlinearities. By modeling the subcritical mode kinetically, and the impact of the supercritical mode by simple wave-wave coupling equations, it is shown that this new kind of subcritical instability can be triggered, even when the frequency of the supercritical mode is rapidly sweeping. The model is applied to the bursty onset of geodesic acoustic modes in a LHD experiment. The model recovers several key features such as relative amplitude, time scales, and phase relations. It suggests that the strongest bursts are subcritical instabilities, driven by this mechanism of combined fluid and kinetic nonlinearities.

  16. Nonlinear Excitation of Subcritical Instabilities in a Toroidal Plasma.

    PubMed

    Lesur, M; Itoh, K; Ido, T; Osakabe, M; Ogawa, K; Shimizu, A; Sasaki, M; Ida, K; Inagaki, S; Itoh, S-I

    2016-01-01

    In a collisionless plasma, it is known that linearly stable modes can be destabilized (subcritically) by the presence of structures in phase space. However, nonlinear growth requires the presence of a seed structure with a relatively large threshold in amplitude. We demonstrate that, in the presence of another, linearly unstable (supercritical) mode, wave-wave coupling can provide a seed, which is significantly below the threshold, but can still grow by (and only by) the collaboration of fluid and kinetic nonlinearities. By modeling the subcritical mode kinetically, and the impact of the supercritical mode by simple wave-wave coupling equations, it is shown that this new kind of subcritical instability can be triggered, even when the frequency of the supercritical mode is rapidly sweeping. The model is applied to the bursty onset of geodesic acoustic modes in a LHD experiment. The model recovers several key features such as relative amplitude, time scales, and phase relations. It suggests that the strongest bursts are subcritical instabilities, driven by this mechanism of combined fluid and kinetic nonlinearities. PMID:26799024

  17. Neutronics for critical fission reactors and subcritical fission in hybrids

    NASA Astrophysics Data System (ADS)

    Salvatores, Massimo

    2012-06-01

    The requirements of future innovative nuclear fuel cycles will focus on safety, sustainability and radioactive waste minimization. Critical fast neutron reactors and sub-critical, external source driven systems (accelerator driven and fusion-fission hybrids) have a potential role to meet these requirements in view of their physics characteristics. This paper provides a short introduction to these features.

  18. Subcritical crack-growth behavior in advanced silicon nitride ceramics

    NASA Astrophysics Data System (ADS)

    Bhatnagar, Ajay

    Advanced silicon nitride ceramics (Sisb3Nsb4) are leading candidates for structural components in gas turbine and reciprocating engines. However, widespread use of these materials has been deterred due to their low fracture toughness under tensile loads. In the last decade, novel processing techniques have allowed extrinsic toughening of this material through grain bridging processes. The extrinsic toughening mechanisms, however, are prone to subcritical crack-growth processes through environmental, mechanical and high temperature degradation mechanisms. Understanding these failure mechanisms is critical for long term reliability and design. In the first part of this study, fracture and environmentally-assisted subcritical crack-growth processes were examined in bulk Y-Si-Al-O-N oxynitride glasses with compositions typical of the grain boundary phase of silicon nitride ceramics. Both long crack as well as short crack behavior were investigated to establish a reliable fracture toughness value and to elucidate the anomalous densification behavior of the oxynitride glass under indentation loads. Environmentally assisted subcritical crack-growth processes were studied in inert, moist and wet environments under both cyclic and static loading conditions and compared to commercial soda lime and borosilicate glasses. The second part of this study involved the effect of loading, microstructure and temperature on subcritical crack-growth behavior in silicon nitride ceramics. Crack-growth rates under an alternating applied stress intensity were compared to those under static loads. The effect of microstructure on fatigue crack-growth rates was determined in silicon nitrides sintered using different processing techniques and with different grain sizes. Unique experimental techniques were used to determine subcritical crack-growth behavior from room temperature to elevated temperatures of 1250sp°C. Frictional wear models were used to explain the trends in experimental data at

  19. [REITER'S SYNDROME FOLLOWING INTRAVASICAL BCG THERAPY FOR UROTHELIAL CARCINOMA. SUMMARY OF CASE REPORTS OVER THE PAST 13 YEARS IN JAPAN, INCLUDING OUR CURRENT 6 CASES].

    PubMed

    Koike, Mayumi; Natsuyama, Takao; Matsuzaki, Kanako; Yokota, Eisuke; Shiozawa, Shinji; Chiba, Kazuto; Akakura, Koichiro

    2015-10-01

    Reiter's syndrome is one of the rare complications following intravesical bovis Bacillus Calmette-Guerin (BCG) treatment. In this study we have reviewed and discussed 101 cases including our own 6 cases over the past 13 years in Japan (2000-2013). The patients comprised 70 males and 25 females (6 cases were unknown), mean age of 63.1 (range 42 - 91). Arthritis occured 4-5 days after conjunctivitis. Thirty five (55%) of 68 patients needed corticosteroid treatment to control their arthritis. HLA-B27 is known as a risk factor of Reiter's syndrome, however, positive rate was only 2.4% (n = 41). PMID:26717781

  20. Interdroplet attractive forces in AOT water-in-oil microemulsions formed in subcritical and supercritical solvents

    SciTech Connect

    Tingey, J.M.; Fulton, J.L.; Smith, R.D. )

    1990-03-08

    The van der Waals attractive interactions between aqueous droplets in water-in-oil type microemulsions have been investigated for a range of continuous-phase solvents including the alkanes from methane to isooctane and the noble gases, krypton and xenon. Hamaker constants for water droplets with surfactant shells of the sodium bis(2-ethylhexyl) sulfosuccinate (AOT) in subcritical and supercritical solvents were calculated by using Lifshitz theory and the resulting interaction potential calculations qualitatively account for many features of the phase behavior of these systems.

  1. Initial Business Case Analysis of Two Integrated Heat Pump HVAC Systems for Near-Zero-Energy Homes - Update to Include Evaluation of Impact of Including a Humidifier Option

    SciTech Connect

    Baxter, Van D

    2007-02-01

    --A Stage 2 Scoping Assessment, ORNL/TM-2005/194 (Baxter 2005). The 2005 study report describes the HVAC options considered, the ranking criteria used, and the system rankings by priority. In 2006, the two top-ranked options from the 2005 study, air-source and ground-source versions of a centrally ducted integrated heat pump (IHP) system, were subjected to an initial business case study. The IHPs were subjected to a more rigorous hourly-based assessment of their performance potential compared to a baseline suite of equipment of legally minimum efficiency that provided the same heating, cooling, water heating, demand dehumidification, and ventilation services as the IHPs. Results were summarized in a project report, Initial Business Case Analysis of Two Integrated Heat Pump HVAC Systems for Near-Zero-Energy Homes, ORNL/TM-2006/130 (Baxter 2006a). The present report is an update to that document which summarizes results of an analysis of the impact of adding a humidifier to the HVAC system to maintain minimum levels of space relative humidity (RH) in winter. The space RH in winter has direct impact on occupant comfort and on control of dust mites, many types of disease bacteria, and 'dry air' electric shocks. Chapter 8 in ASHRAE's 2005 Handbook of Fundamentals (HOF) suggests a 30% lower limit on RH for indoor temperatures in the range of {approx}68-69F based on comfort (ASHRAE 2005). Table 3 in chapter 9 of the same reference suggests a 30-55% RH range for winter as established by a Canadian study of exposure limits for residential indoor environments (EHD 1987). Harriman, et al (2001) note that for RH levels of 35% or higher, electrostatic shocks are minimized and that dust mites cannot live at RH levels below 40%. They also indicate that many disease bacteria life spans are minimized when space RH is held within a 30-60% range. From the foregoing it is reasonable to assume that a winter space RH range of 30-40% would be an acceptable compromise between comfort

  2. Disposition of Nuclear Waste Using Subcritical Accelerator-Driven Systems: Technology Choices and Implementation Scenarios

    SciTech Connect

    Venneri, Francesco; Williamson, Mark A.; Li Ning; Houts, Michael G.; Morley, Richard A.; Beller, Denis E.; Sailor, William; Lawrence, George

    2000-10-15

    Los Alamos National Laboratory has led the development of accelerator-driven transmutation of waste (ATW) to provide an alternative technological solution to the disposition of nuclear waste. While ATW will not eliminate the need for a high-level waste repository, it offers a new technology option for altering the nature of nuclear waste and enhancing the capability of a repository. The basic concept of ATW focuses on reducing the time horizon for the radiological risk from hundreds of thousands of years to a few hundred years and on reducing the thermal loading. As such, ATW will greatly reduce the amount of transuranic elements that will be disposed of in a high-level waste repository. The goal of the ATW nuclear subsystem is to produce three orders of magnitude reduction in the long-term radiotoxicity of the waste sent to a repository, including losses through processing. If the goal is met, the radiotoxicity of ATW-treated waste after 300 yr would be less than that of untreated waste after 100 000 yr.These objectives can be achieved through the use of high neutron fluxes produced in accelerator-driven subcritical systems. While critical fission reactors can produce high neutron fluxes to destroy actinides and select fission products, the effectiveness of the destruction is limited by the criticality requirement. Furthermore, a substantial amount of excess reactivity would have to be supplied initially and compensated for by control poisons. To overcome these intrinsic limitations, we searched for solutions in subcritical systems freed from the criticality requirement by taking advantage of the recent breakthroughs in accelerator technology and the release of liquid lead/bismuth nuclear coolant technology from Russia. The effort led to the selection of an accelerator-driven subcritical system that results in the destruction of the actinides and fission products of concern as well as permitting easy operational control through the external control of the neutron

  3. Spectrum of cytopathologic features of epithelioid sarcoma in a series of 7 uncommon cases with immunohistochemical results, including loss of INI1/SMARCB1 in two test cases.

    PubMed

    Rekhi, Bharat; Singh, Neha

    2016-07-01

    Diagnosis of an epithelioid sarcoma (ES) is challenging on fine needle aspiration cytology (FNAC) smears. There are few documented series describing cytopathologic features and immunostaining results of ESs. The present study describes cytopathologic features of seven cases of ES. All seven tumors occurred in males within age-range of 22-61 years; in sites, such as forearm (n = 3), hand (n = 2), thigh (n = 1), and inguinal region (n = 1). FNAC was performed for metastatic lesions (n = 5), recurrent lesions (n = 4), as well as for a primary diagnosis (n = 1). FNAC smears in most cases were moderate to hypercellular, composed of polygonal cells(seven cases) and spindle cells(three cases), arranged in loosely cohesive groups, non-overlapping clusters, and scattered singly, containing moderate to abundant cytoplasm, defined cell borders, vesicular nuclei, and discernible nucleoli. Variable cytopathologic features identified in certain cases were "rhabdoid-like" intracytoplasmic inclusions (n = 5), giant cells (n = 3), and interspersed scanty, metachromatic stroma (n = 4). Histopathologic examination revealed two cases of conventional-type ES, three of proximal/large cell-type ES, and two cases of mixed-type ES, displaying features of conventional and proximal subtypes. By immunohistochemistry (IHC), tumor cells were positive for cytokeratin (CK)(4/5), epithelial membrane antigen (EMA) (6/6), panCK (1/1), vimentin (3/3), and CD34 (7/7). Tumor cells were completely negative for INI1/SMARCB1 (0/2) and CD31 (0/5). In our settings, FNAC was mostly performed in recurrent and/or metastatic cases of ES, and rarely for a primary diagnosis of ES. Important cytopathologic features of ESs include loosely cohesive, non-overlapping clusters of polygonal cells with variable "rhabdoid-like" and spindle cells. Optimal diagnostic IHC markers in such cases include CK, EMA, AE1AE3, CD34, and INI1/SMARCB1. Clinical correlation is imperative in all

  4. Fatigue of Self-Healing Nanofiber-based Composites: Static Test and Subcritical Crack Propagation.

    PubMed

    Lee, Min Wook; Sett, Soumyadip; Yoon, Sam S; Yarin, Alexander L

    2016-07-20

    Here, we studied the self-healing of composite materials filled with epoxy-containing nanofibers. An initial incision in the middle of a composite sample stretched in a static fatigue test can result in either crack propagation or healing. In this study, crack evolution was observed in real time. A binary epoxy, which acted as a self-healing agent, was encapsulated in two separate types of interwoven nano/microfibers formed by dual-solution blowing, with the core containing either epoxy or hardener and the shell being formed from poly(vinylidene fluoride)/ poly(ethylene oxide) mixture. The core-shell fibers were encased in a poly(dimethylsiloxane) matrix. When the fibers were damaged by a growing crack in this fiber-reinforced composite material because of static stretching in the fatigue test, they broke and released the healing agent into the crack area. The epoxy used in this study was cured and solidified for approximately an hour at room temperature, which then conglutinated and healed the damaged location. The observations were made for at least several hours and in some cases up to several days. It was revealed that the presence of the healing agent (the epoxy) in the fibers successfully prevented the propagation of cracks in stretched samples subjected to the fatigue test. A theoretical analysis of subcritical cracks was performed, and it revealed a jumplike growth of subcritical cracks, which was in qualitative agreement with the experimental results. PMID:27332924

  5. Clinicopathological features of five unusual cases of intraosseous myoepithelial carcinomas, mimicking conventional primary bone tumours, including EWSR1 rearrangement in one case.

    PubMed

    Rekhi, Bharat; Joshi, Sujit; Panchwagh, Yogesh; Gulia, Ashish; Borges, Anita; Bajpai, Jyoti; Jambehekar, Nirmala A; Pant, Vinita; Mandholkar, Mahesh; Byregowda, Suman; Puri, Ajay

    2016-04-01

    Primary intraosseous myoepithelial tumours, including carcinomas are rare tumours. The concept of histopathological spectrum of these tumours is evolving. We describe clinicopathological and immunohistochemical features of five myoepithelial carcinomas, including molecular cytogenetic results in one case. There were five male patients within age-range of 8-40 years (median = 26). Four tumours occurred in the long bones, including two tumours, each, in the femur and fibula, respectively, while a single tumour occurred in the proximal phalanges. Tumour size (n = 3 cases) varied from 5.6 to 8.6 cm. On radiological imaging, most tumours appeared as expansile, lytic and destructive lesions. Two tumours appeared as sclerotic lesions. Two cases were referred with diagnoses of chondrosarcomas and a single case was referred with two different diagnoses, including an adamantinoma and an osteosarcoma. Histopathological examination in all these cases showed multinodular tumours comprising mostly polygonal cells, exhibiting moderate nuclear atypia and interspersed mitotic figures within a stroma containing variable amount of myxoid, chondroid, hyalinised and osteoid-like material. Three tumours revealed prominent squamous differentiation. By immunohistochemistry, tumour cells were positive for EMA (5/5), pan CK (AE1/AE3) (3/3), CK5/6 (4/4), CK MNF116 (1/1), S100 protein (5/5) and GFAP (3/5). The first tumour revealed EWSR1 rearrangement. The first patient, 10 months after tumour resection and a simultaneous lung metastatectomy, is free-of-disease (FOD). The second patient, 11 months after tumour resection is FOD. The third and fourth patients underwent wide resections and are on follow-up. The fifth patient underwent resections, including a lung metastatectomy. Primary intraosseous myoepithelial carcinomas are rare and mimic conventional primary bone tumours. Some primary intraosseous myoepithelial carcinomas display EWSR1 rearrangement. Squamous differentiation may be

  6. Droplet turbulence interactions under subcritical and supercritical conditions

    NASA Technical Reports Server (NTRS)

    Coy, E. B.; Greenfield, S. C.; Ondas, M. S.; Song, Y.-H.; Spegar, T. D.; Santavicca, D. A.

    1993-01-01

    The goal of this research is to experimentally characterize the behavior of droplets in vaporizing liquid sprays under conditions typical of those encountered in high pressure combustion systems such as liquid fueled rocket engines. Of particular interest are measurements of droplet drag, droplet heating, droplet vaporization, droplet distortion, and secondary droplet breakup, under both subcritical and supercritical conditions. The paper presents a brief description of the specific accomplishments which have been made over the past year.

  7. Dynamic analysis of an accelerator-driven fluid-fueled subcritical radioactive waste burning system

    SciTech Connect

    Woosley, M.L. Jr.; Rydin, R.A.

    1998-05-01

    The recent revival of interest in accelerator-driven subcritical fluid-fueled systems is documented. Several important applications of these systems are mentioned, and this is used to motivate the need for dynamic analysis of the nuclear kinetics of such systems. A physical description of the Los alamos National Laboratory accelerator-based conversion (ABC) concept is provided. This system is used as the basis for the kinetics study in this research. The current approach to the dynamic simulation of an accelerator-driven subcritical fluid-fueled system includes four functional elements: a discrete ordinates model is used to calculate the flux distribution for the source-driven system; a nodal convection model is used to calculate time-dependent isotope and temperature distributions that impact reactivity; a nodal importance weighting model is used to calculate the reactivity impact of temperature and isotope distributions and to feed this information back to the time-dependent nodal convection model; and a transient driver is used to simulate transients, model the balance of plant, and record simulation data. Specific transients that have been analyzed with the current modeling system are discussed. These transients include loss-of-flow and loss-of-cooling accidents, xenon and samarium transients, and cold-plug and overfueling events. The results of various transients have uncovered unpredictable behavior, unresolved design issues, and the need for active control. The need for the development of a nodal-coupling spatial kinetics model is mentioned.

  8. Scattering of gravity waves in subcritical flows over an obstacle

    NASA Astrophysics Data System (ADS)

    Robertson, Scott; Michel, Florent; Parentani, Renaud

    2016-06-01

    We numerically study the scattering coefficients of linear water waves on stationary flows above a localized obstacle. We compare the scattering on trans- and subcritical flows, and then focus on the latter which have been used in recent analog gravity experiments. The main difference concerns the magnitude of the mode amplification: whereas transcritical flows display a large amplification (which is generally in good agreement with the Hawking prediction), this effect is heavily suppressed in subcritical flows. This is due to the transmission across the obstacle for frequencies less than some critical value. As a result, subcritical flows display high- and low-frequency behaviors separated by a narrow band around the critical frequency. In the low-frequency regime, transmission of long wavelengths is accompanied by nonadiabatic scattering into short wavelengths, whose spectrum is approximately linear in frequency. By contrast, in the high-frequency regime, no simple description seems to exist. In particular, for obstacles similar to those recently used, we observe that the upstream slope still affects the scattering on the downstream side because of some residual transmission.

  9. Extraction of tricyclazole from soil and sediment with subcritical water.

    PubMed

    Krieger, M S; Cook, W L; Kennard, L M

    2000-06-01

    The use of subcritical water to extract tricyclazole from soils and sediments was examined. Extraction efficiency and kinetics were determined as a function of temperature, sample age, sample matrix, sample size, and flow rate. Extraction temperature was the most influential experimental factor affecting extraction efficiency and kinetics, with increasing temperature (up to 150 degrees C) yielding faster and higher efficiency extractions. Higher extraction temperatures were also important for quantitative recovery of tricyclazole from aged samples. Extraction at 50 degrees C yielded 97% recoveries from samples aged 1 day but only 30% recoveries for samples aged 202 days, whereas extraction at 150 degrees C yielded recoveries of 85-100% that were independent of incubation time and sample matrix, with the exception of one sediment that contained a large amount of organic matter. Sample extracts from subcritical water extraction were generally a pale yellow color, contrasted with a dark brown color from organic solvent extractions of the same matrixes. Less sample cleanup was therefore required prior to analysis, with the total time for the extraction and analysis of a single sample being approximately 2 h. Subcritical water extraction is an effective technique for the rapid and quantitative extraction of tricyclazole from soils and sediments. PMID:10888518

  10. PNS and statistical experiments simulation in subcritical systems using Monte-Carlo method on example of Yalina-Thermal assembly

    NASA Astrophysics Data System (ADS)

    Sadovich, Sergey; Talamo, A.; Burnos, V.; Kiyavitskaya, H.; Fokov, Yu.

    2014-06-01

    In subcritical systems driven by an external neutron source, the experimental methods based on pulsed neutron source and statistical techniques play an important role for reactivity measurement. Simulation of these methods is very time-consumed procedure. For simulations in Monte-Carlo programs several improvements for neutronic calculations have been made. This paper introduces a new method for simulation PNS and statistical measurements. In this method all events occurred in the detector during simulation are stored in a file using PTRAC feature in the MCNP. After that with a special code (or post-processing) PNS and statistical methods can be simulated. Additionally different shapes of neutron pulses and its lengths as well as dead time of detectors can be included into simulation. The methods described above were tested on subcritical assembly Yalina-Thermal, located in Joint Institute for Power and Nuclear Research SOSNY, Minsk, Belarus. A good agreement between experimental and simulated results was shown.

  11. Monte Carlo modeling and analyses of YALINA booster subcritical assembly, Part III : low enriched uranium conversion analyses.

    SciTech Connect

    Talamo, A.; Gohar, Y.

    2011-05-12

    This study investigates the performance of the YALINA Booster subcritical assembly, located in Belarus, during operation with high (90%), medium (36%), and low (21%) enriched uranium fuels in the assembly's fast zone. The YALINA Booster is a zero-power, subcritical assembly driven by a conventional neutron generator. It was constructed for the purpose of investigating the static and dynamic neutronics properties of accelerator driven subcritical systems, and to serve as a fast neutron source for investigating the properties of nuclear reactions, in particular transmutation reactions involving minor-actinides. The first part of this study analyzes the assembly's performance with several fuel types. The MCNPX and MONK Monte Carlo codes were used to determine effective and source neutron multiplication factors, effective delayed neutron fraction, prompt neutron lifetime, neutron flux profiles and spectra, and neutron reaction rates produced from the use of three neutron sources: californium, deuterium-deuterium, and deuterium-tritium. In the latter two cases, the external neutron source operates in pulsed mode. The results discussed in the first part of this report show that the use of low enriched fuel in the fast zone of the assembly diminishes neutron multiplication. Therefore, the discussion in the second part of the report focuses on finding alternative fuel loading configurations that enhance neutron multiplication while using low enriched uranium fuel. It was found that arranging the interface absorber between the fast and the thermal zones in a circular rather than a square array is an effective method of operating the YALINA Booster subcritical assembly without downgrading neutron multiplication relative to the original value obtained with the use of the high enriched uranium fuels in the fast zone.

  12. [A Case of Multiple HCC with Vp2 and Vv3 Invasion Controlled by Multidisciplinary Treatment Including Surgery].

    PubMed

    Deguchi, Sota; Tsukamoto, Tadashi; Kanazawa, Akishige; Shimizu, Sadatoshi; Yamamoto, Satoshi; Murata, Akihiro; Nakajima, Takayoshi; Sakae, Masayuki; Tachimori, Akiko; Tamamori, Yutaka; Yamamoto, Atsushi; Inoue, Toru; Yamashita, Yoshito; Nishiguchi, Yukio

    2015-11-01

    The prognosis of HCC with vascular invasion is dismal, but surgery is elected when the hepatic reserve is adequate. The case involved a 68-year-old male HCV carrier. A 10 cm diameter tumor occupying the central 2 segments of the liver and liver metastasis in the left lobe were detected. The patient was diagnosed with multiple HCC with severe vascular invasion of Vp2 and Vv3. The tumor shrunk dramatically after starting HAIC therapy with cisplatin and oral administration of sorafenib. A laparoscopic partial hepatectomy was performed for the viable lesion. The tumor showed almost complete coagulative necrosis. Multiple hepatic metastases were found 4 months after surgery, but the tumor was under control at 25 months after the first HAIC due to HAIC, oral administration of sorafenib, and RFA. An improved prognosis for multiple HCC with severe vascular invasion can be expected by performing multidisciplinary treatments including surgery. PMID:26805192

  13. Effects of TRU Distributions of Electron Accelerator-Driven Subcritical Core Systems on Transmutation

    SciTech Connect

    Yodersmith, Stephen; Yim, Man-Sung

    2007-07-01

    As part of the effort to investigate the use of an electron accelerator driven system for TRU transmutation, the effects of TRU distributions in the core on transmuter system performance was examined in this paper. The system performance examined includes the transmutation and system power efficiency and changes in power peaking. The transmutation benefits of the system were determined with the introduction of a new parameter, the Transmutation System Effectiveness Parameter (TSEP). TSEP combines the decay heat and radioactivity results into one single parameter that compares the ability of the system to reduce the radioactivity and decay heat of the loaded TRUs. The electron ADS was modeled by using MCNPX and MONTEBURNS as a fast spectrum, Na cooled reactor loosely based on the advanced liquid metal reactor (ALMR) design. NJOY was used to process the cross sections at the desired temperatures. The fuel was a TRUZr alloy contained within an HT-9 SS cladding. The subcritical reactor contained four different fuel zones with an equal number of fuel assemblies in each region, each containing one of the four TRU elements: Np, Pu, Cm, Am. Tungsten was used for the target system. The electron ADS was assumed to operate at 500 MWth over a 24 month cycle. Results showed that different distribution patterns had a very insignificant effect on the total radioactivity reduction, the total decay heat reduction, and the TRU radiotoxicity reduction. With respect to the TSEP parameter, the calculation results revealed a much stronger dependence on TRU distributions. It seemed that TSEP accurately reflected and penalized the effectiveness of the system for the fission product production. With respect to examining the k{sub eff} over the cycle, a drastic difference was observed between the cases when Pu is located in the inner most region and the rest of the patterns. The k{sub eff} for the Pu in the inner most region cases decreased at a much faster rate than did the rest therefore

  14. Ultrasound-Enhanced Subcritical CO2 Extraction of Lutein from Chlorella pyrenoidosa.

    PubMed

    Fan, Xiao-Dan; Hou, Yan; Huang, Xing-Xin; Qiu, Tai-Qiu; Jiang, Jian-Guo

    2015-05-13

    Lutein is an important pigment of Chlorella pyrenoidosa with many beneficial functions in human health. The main purpose of this study was to extract lutein from C. pyrenoidosa using ultrasound-enhanced subcritical CO2 extraction (USCCE). Effects of operating conditions on the extraction, including extraction pretreatment, temperature, pressure, time, CO2 flow rate, and ultrasonic power, were investigated, and an orthogonal experiment was designed to study the effects of extraction pressure, temperature, cosolvent amount, and time on the extraction yields. The USCCE method was compared with other extraction methods in terms of the yields of lutein and the microstructure of C. pyrenoidosa powder by scanning electron microscopy. A maximal extraction yield of 124.01 mg lutein/100 g crude material was achieved under optimal conditions of extraction temperature at 27 °C, extraction pressure at 21 MPa, cosolvent amount at 1.5 mL/g ethanol, and ultrasound power at 1000 W. Compared to other methods, USCCE could significantly increase the lutein extraction yield at lower extraction temperature and pressure. Furthermore, the kinetic models of USCCE and subcritical CO2 extraction (SCCE) of lutein from C. pyrenoidosa were set as E = 130.64 × (1 - e(-0.6599t)) and E = 101.82 × (1 - e(-0.5683t)), respectively. The differences of parameters in the kinetic models indicate that ultrasound was able to enhance the extraction process of SCCE. PMID:25837869

  15. Extraction characteristics of subcritical water depending on the number of hydroxyl group in flavonols.

    PubMed

    Cheigh, Chan-Ick; Yoo, Seo-Yeon; Ko, Min-Jung; Chang, Pahn-Shick; Chung, Myong-Soo

    2015-02-01

    This study compared the efficiencies of using subcritical water, hot water, and organic solvents to extract flavonols from black tea, celery, and ginseng leaf. The effect of key operating conditions was determined by varying the temperature (110-200°C), extraction time (5-15min), and pressure (about 10MPa) and the extracts were analysed quantitatively using HPLC. The yields of myricetin, quercetin, and kaempferol from plants were maximal at extraction temperatures of 170°C, 170°C and 200°C, respectively, and they depend on the number of hydroxyl groups included in the chemical structure of the flavonols, with more of those with fewer hydroxyl (OH) groups attached being extracted at higher temperatures. The results also showed that the yields of flavonols by subcritical water extraction were 2.0- to 22.7- and 1.8- to 23.6-fold higher than those obtained using the ethanol and methanol as traditional extraction methods, respectively. PMID:25172678

  16. Biological shield design and analysis of KIPT accelerator-driven subcritical facility.

    SciTech Connect

    Zhong, Z.; Gohar, Y.; Nuclear Engineering Division

    2009-12-01

    Argonne National Laboratory of the United States and Kharkov Institute of Physics and Technology of Ukraine have been collaborating on the conceptual design development of an electron accelerator-driven subcritical facility. The facility will be utilized for performing basic and applied nuclear research, producing medical isotopes, and training young nuclear specialists. This paper presents the design and analyses of the biological shield performed for the top section of the facility. The neutron source driving the subcritical assembly is generated from the interaction of a 100-kW electron beam with a natural uranium target. The electron energy is in the range of 100 to 200 MeV, and it has a uniform spatial distribution. The shield design and the associated analyses are presented including different parametric studies. In the analyses, a significant effort was dedicated to the accurate prediction of the radiation dose outside the shield boundary as a function of the shield thickness without geometrical approximations or material homogenization. The MCNPX Monte Carlo code was utilized for the transport calculation of electrons, photons, and neutrons. Weight window variance-reduction techniques were introduced, and the dose equivalent outside the shield can be calculated with reasonably good statistics.

  17. Radioactive isotope production for medical applications using Kharkov electron driven subcritical assembly facility.

    SciTech Connect

    Talamo, A.; Gohar, Y.; Nuclear Engineering Division

    2007-05-15

    Kharkov Institute of Physics and Technology (KIPT) of Ukraine has a plan to construct an accelerator driven subcritical assembly. The main functions of the subcritical assembly are the medical isotope production, neutron thereby, and the support of the Ukraine nuclear industry. Reactor physics experiments and material research will be carried out using the capabilities of this facility. The United States of America and Ukraine have started collaboration activity for developing a conceptual design for this facility with low enrichment uranium (LEU) fuel. Different conceptual designs are being developed based on the facility mission and the engineering requirements including nuclear physics, neutronics, heat transfer, thermal hydraulics, structure, and material issues. Different fuel designs with LEU and reflector materials are considered in the design process. Safety, reliability, and environmental considerations are included in the facility conceptual design. The facility is configured to accommodate future design improvements and upgrades. This report is a part of the Argonne National Laboratory Activity within this collaboration for developing and characterizing the subcritical assembly conceptual design. In this study, the medical isotope production function of the Kharkov facility is defined. First, a review was carried out to identify the medical isotopes and its medical use. Then a preliminary assessment was performed without including the self-shielding effect of the irradiated samples. Finally, more detailed investigation was carried out including the self-shielding effect, which defined the sample size and irradiation location for producing each medical isotope. In the first part, the reaction rates were calculated as the multiplication of the cross section with the unperturbed neutron flux of the facility. Over fifty isotopes were considered and all transmutation channels are used including (n,{gamma}), (n,2n), (n,p), and ({gamma},n). In the second part

  18. Relationship between Urinary N-Desmethyl-Acetamiprid and Typical Symptoms including Neurological Findings: A Prevalence Case-Control Study.

    PubMed

    Marfo, Jemima Tiwaa; Fujioka, Kazutoshi; Ikenaka, Yoshinori; Nakayama, Shouta M M; Mizukawa, Hazuki; Aoyama, Yoshiko; Ishizuka, Mayumi; Taira, Kumiko

    2015-01-01

    Neonicotinoid insecticides are nicotinic acetylcholine receptor agonists used worldwide. Their environmental health effects including neurotoxicity are of concern. We previously determined a metabolite of acetamiprid, N-desmethyl-acetamiprid in the urine of a patient, who exhibited some typical symptoms including neurological findings. We sought to investigate the association between urinary N-desmethyl-acetamiprid and the symptoms by a prevalence case-control study. Spot urine samples were collected from 35 symptomatic patients of unknown origin and 50 non-symptomatic volunteers (non-symptomatic group, NSG, 4-87 year-old). Patients with recent memory loss, finger tremor, and more than five of six symptoms (headache, general fatigue, palpitation/chest pain, abdominal pain, muscle pain/weakness/spasm, and cough) were in the typical symptomatic group (TSG, n = 19, 5-69 year-old); the rest were in the atypical symptomatic group (ASG, n = 16, 5-78 year-old). N-desmethyl-acetamiprid and six neonicotinoids in the urine were quantified by liquid chromatography-tandem mass spectrometry. The detection of N-desmethyl-acetamiprid was the most frequent and highest in TSG (47.4%, 6.0 ppb (frequency, maximum)), followed by in ASG (12.5%, 4.4 ppb) and in NSG (6.0%, 2.2 ppb), however acetamiprid was not detected. Thiamethoxam was detected in TSG (31.6%, 1.4 ppb), in ASG (6.3%, 1.9 ppb), but not in NSG. Nitenpyram was detected in TSG (10.5%, 1.2 ppb), in ASG (6.3%, not quantified) and in NSG (2.0%, not quantified). Clothianidin was only detected in ASG (6.3%, not quantified), and in NSG (2.0%, 1.6 ppb). Thiacloprid was detected in ASG (6.3%, 0.1 ppb). The cases in TSG with detection of N-desmethyl-acetamiprid and thiamethoxam were aged 5 to 62 years and 13 to 62 years, respectively. Detection of N-desmethyl-acetamiprid was associated with increased prevalence of the symptoms (odds ratio: 14, 95% confidence interval: 3.5-57). Urinary N-desmethyl-acetamiprid can be used as a

  19. Relationship between Urinary N-Desmethyl-Acetamiprid and Typical Symptoms including Neurological Findings: A Prevalence Case-Control Study

    PubMed Central

    Ikenaka, Yoshinori; Nakayama, Shouta M. M.; Mizukawa, Hazuki; Aoyama, Yoshiko; Ishizuka, Mayumi; Taira, Kumiko

    2015-01-01

    Neonicotinoid insecticides are nicotinic acetylcholine receptor agonists used worldwide. Their environmental health effects including neurotoxicity are of concern. We previously determined a metabolite of acetamiprid, N-desmethyl-acetamiprid in the urine of a patient, who exhibited some typical symptoms including neurological findings. We sought to investigate the association between urinary N-desmethyl-acetamiprid and the symptoms by a prevalence case-control study. Spot urine samples were collected from 35 symptomatic patients of unknown origin and 50 non-symptomatic volunteers (non-symptomatic group, NSG, 4–87 year-old). Patients with recent memory loss, finger tremor, and more than five of six symptoms (headache, general fatigue, palpitation/chest pain, abdominal pain, muscle pain/weakness/spasm, and cough) were in the typical symptomatic group (TSG, n = 19, 5–69 year-old); the rest were in the atypical symptomatic group (ASG, n = 16, 5–78 year-old). N-desmethyl-acetamiprid and six neonicotinoids in the urine were quantified by liquid chromatography-tandem mass spectrometry. The detection of N-desmethyl-acetamiprid was the most frequent and highest in TSG (47.4%, 6.0 ppb (frequency, maximum)), followed by in ASG (12.5%, 4.4 ppb) and in NSG (6.0%, 2.2 ppb), however acetamiprid was not detected. Thiamethoxam was detected in TSG (31.6%, 1.4 ppb), in ASG (6.3%, 1.9 ppb), but not in NSG. Nitenpyram was detected in TSG (10.5%, 1.2 ppb), in ASG (6.3%, not quantified) and in NSG (2.0%, not quantified). Clothianidin was only detected in ASG (6.3%, not quantified), and in NSG (2.0%, 1.6 ppb). Thiacloprid was detected in ASG (6.3%, 0.1 ppb). The cases in TSG with detection of N-desmethyl-acetamiprid and thiamethoxam were aged 5 to 62 years and 13 to 62 years, respectively. Detection of N-desmethyl-acetamiprid was associated with increased prevalence of the symptoms (odds ratio: 14, 95% confidence interval: 3.5–57). Urinary N-desmethyl-acetamiprid can be used as a

  20. A case of 9.7 Mb terminal Xp deletion including OA1 locus associated with contiguous gene syndrome.

    PubMed

    Cho, Eun-Hae; Kim, Sook-Young; Kim, Jin-Kyung

    2012-10-01

    Terminal or interstitial deletions of Xp (Xp22.2→Xpter) in males have been recognized as a cause of contiguous gene syndromes showing variable association of apparently unrelated clinical manifestations such as Leri-Weill dyschondrosteosis (SHOX), chondrodysplasia punctata (CDPX1), mental retardation (NLGN4), ichthyosis (STS), Kallmann syndrome (KAL1), and ocular albinism (GPR143). Here we present a case of a 13.5 yr old boy and sister with a same terminal deletion of Xp22.2 resulting in the absence of genes from the telomere of Xp to GPR143 of Xp22. The boy manifested the findings of all of the disorders mentioned above. We began a testosterone enanthate monthly replacement therapy. His sister, 11 yr old, manifested only Leri-Weill dyschondrosteosis, and had engaged in growth hormone therapy for 3 yr. To the best of our knowledge, this is the first report of a male with a 9.7 Mb terminal Xp deletion including the OA1 locus in Korea. PMID:23091330

  1. How to detect polymorphisms undergoing selection in marine fishes? A review of methods and case studies, including flatfishes

    NASA Astrophysics Data System (ADS)

    Guinand, Bruno; Lemaire, Christophe; Bonhomme, François

    2004-05-01

    Populations of marine organisms are potentially affected by numerous selective pressures such as temperature and salinity, or anthropogenic pressures such as xenobiotics that may preclude adaptation to particular habitats. Such selective pressures may also affect their demography. Examples include modifications of the population dynamics through shifts in growth rate, and in life history traits affecting fitness such as size or age of first reproduction. However, the documentation of variation in phenotypically plastic traits specific to distinct environments cannot be taken as the ultimate proof that natural selection has occurred. Measurement of the impact of selection and subsequent local adaptation of fish populations based exclusively on morphological or physiological characters is one of the most difficult things to achieve because it depends on the use of phenotypic characters that closely match the genotype. Molecular markers can help to overcome this problem and, under some circumstances, can record the footprints of selection. A combination of polymorphisms that are under selection and those that are not can provide complementary information. In this paper, we review how and why selection can be detected at the molecular level, using genetic markers analysed in a population genetic framework. We then report and discuss case studies in fish.

  2. Benzo(a)pyrene accumulation in soils of technogenic emission zone by subcritical water extraction method

    NASA Astrophysics Data System (ADS)

    Sushkova, Svetlana; Minkina, Tatiana; Kizilkaya, Ridvan; Mandzhieva, Saglara; Batukaev, Abdulmalik; Bauer, Tatiana; Gulser, Coskun

    2016-04-01

    The purpose of research is the assessment of main marker of polycyclic aromatic hydrocarbons contamination, benzo[a]pyrene (BaP) content in soils of emission zone of the power complex plant in soils with use of ecologically clean and effective subcritical water extraction method. Studies were conducted on the soils of monitoring plots subjected to Novocherkassk Power Plant emissions from burning coal. In 2000, monitoring plots were established at different distances from the NPS (1.0-20.0 km). Soil samples for the determination of soil properties and the contents of BaP were taken from a depth of 0-20 cm. The soil cover in the region under study consisted of ordinary chernozems, meadow-chernozemic soils, and alluvial meadow soils. This soil revealed the following physical and chemical properties: Corg-3.1-5.0%, pH-7.3-7.6, ECE-31.2-47.6 mmol(+)/100g; CaCO3-0.2-1.0%, the content of physical clay - 51-67% and clay - 3-37%. BaP extraction from soils was carried out by a subcritical water extraction method. Subcritical water extraction of BaP from soil samples was conducted in a specially developed extraction cartridge made of stainless steel and equipped with screw-on caps at both ends. It was also equipped with a manometer that included a valve for pressure release to maintain an internal pressure of 100 atm. The extraction cartridge containing a sample and water was placed into an oven connected to a temperature regulator under temperature 250oC and pressure 60 atm. The BaP concentration in the acetonitrile extract was determined by HPLC. The efficiency of BaP extraction from soil was determined using a matrix spike. The main accumulation of pollutant in 20 cm layer of soils is noted directly in affected zone on the plots situated at 1.2, 1.6, 5.0, 8.0 km from emission source in the direction of prevailing winds. The maximum quantity of a pollutant was founded in the soil of the plot located mostly close to a source of pollution in the direction of prevailing winds

  3. Numerical study of subcritical flow with fluid injection

    NASA Technical Reports Server (NTRS)

    Balasubramanian, R.

    1990-01-01

    It is suggested that the study of synthetic flows, where controlled experiments can be performed, is useful in understanding turbulent flow structures. The early states of formation of hairpin structures in shear flows and the subsequent evolution of these structures is studied in shear flows and the subsequent evolution of these structures is studied through numerical simulations, by developing full-time dependent three-dimensional flow solution of an initially laminar (subcritical) flow in which injection of fluid through a narrow streamwise slot from the bottom wall of a plate is carried out. Details of the numerical approach and significance of the present findings are reported in this work.

  4. Theoretical prediction of airplane stability derivatives at subcritical speeds

    NASA Technical Reports Server (NTRS)

    Tulinius, J.; Clever, W.; Nieman, A.; Dunn, K.; Gaither, B.

    1973-01-01

    The theoretical development and application is described of an analysis for predicting the major static and rotary stability derivatives for a complete airplane. The analysis utilizes potential flow theory to compute the surface flow fields and pressures on any configuration that can be synthesized from arbitrary lifting bodies and nonplanar thick lifting panels. The pressures are integrated to obtain section and total configuration loads and moments due side slip, angle of attack, pitching motion, rolling motion, yawing motion, and control surface deflection. Subcritical compressibility is accounted for by means of the Gothert similarity rule.

  5. Spatial and spectral effects in subcritical system pulsed experiments

    SciTech Connect

    Dulla, S.; Nervo, M.; Ravetto, P.; Carta, M.

    2013-07-01

    Accurate neutronic models are needed for the interpretation of pulsed experiments in subcritical systems. In this work, the extent of spatial and spectral effects in the pulse propagation phenomena is investigated and the analysis is applied to the GUINEVERE experiment. The multigroup cross section data is generated by the Monte Carlo SERPENT code and the neutronic evolution following the source pulse is simulated by a kinetic diffusion code. The results presented show that important spatial and spectral aspects need to be properly accounted for and that a detailed energy approach may be needed to adequately capture the physical features of the system to the pulse injection. (authors)

  6. Applicability of bioanalysis of multiple analytes in drug discovery and development: review of select case studies including assay development considerations.

    PubMed

    Srinivas, Nuggehally R

    2006-05-01

    The development of sound bioanalytical method(s) is of paramount importance during the process of drug discovery and development culminating in a marketing approval. Although the bioanalytical procedure(s) originally developed during the discovery stage may not necessarily be fit to support the drug development scenario, they may be suitably modified and validated, as deemed necessary. Several reviews have appeared over the years describing analytical approaches including various techniques, detection systems, automation tools that are available for an effective separation, enhanced selectivity and sensitivity for quantitation of many analytes. The intention of this review is to cover various key areas where analytical method development becomes necessary during different stages of drug discovery research and development process. The key areas covered in this article with relevant case studies include: (a) simultaneous assay for parent compound and metabolites that are purported to display pharmacological activity; (b) bioanalytical procedures for determination of multiple drugs in combating a disease; (c) analytical measurement of chirality aspects in the pharmacokinetics, metabolism and biotransformation investigations; (d) drug monitoring for therapeutic benefits and/or occupational hazard; (e) analysis of drugs from complex and/or less frequently used matrices; (f) analytical determination during in vitro experiments (metabolism and permeability related) and in situ intestinal perfusion experiments; (g) determination of a major metabolite as a surrogate for the parent molecule; (h) analytical approaches for universal determination of CYP450 probe substrates and metabolites; (i) analytical applicability to prodrug evaluations-simultaneous determination of prodrug, parent and metabolites; (j) quantitative determination of parent compound and/or phase II metabolite(s) via direct or indirect approaches; (k) applicability in analysis of multiple compounds in select

  7. Well Wishes: A Case on Septic Systems and Well Water Requiring In-Depth Analysis and Including Optional Laboratory Experiments

    ERIC Educational Resources Information Center

    Walczak, Mary M.; Lantz, Juliette M.

    2004-01-01

    The case of Well Wishes involves students in a thorough examination of the interaction among nitrogen-composed species in the septic systems and well water, which helps to clean household water. The case supports the attainment of five goals for students, and can be analyzed through classroom discussions or laboratory experiments.

  8. Extending non-fatigue Mode I subcritical crack growth data to subcritical fatigue crack growth: Demonstration of the equivalence of the Charles' law and Paris law exponents

    NASA Astrophysics Data System (ADS)

    Keanini, Russell; Eppes, Martha-Cary

    2016-04-01

    Paris's law connects fatigue-induced subcritical crack growth and fatigue loading. Environmentally-driven subcritical crack growth, while a random process, can be decomposed into a spectrum of cyclic processes, where each spectral component is governed by Paris's law. Unfortunately, almost no data exists concerning the Paris law exponent, m; rather, the great majority of existing sub-critical crack growth measurements on rock have been carried out via Mode I tensile tests, where corresponding data are generally correlated using Charles' law, and where the latter, similar to Paris's law, exposes a power law relationship between crack growth rate and stress intensity. In this study, a statistical argument is used to derive a simple, rigorous relationship between the all-important Paris law and Charles law exponents, m and n. This result has a significant practical implication: subcritical fatigue crack growth in rock, driven by various random environmental weathering processes can now be predicted using available Mode I stress corrosion indices, n.

  9. Subcritical and supercritical water oxidation of CELSS model wastes

    NASA Technical Reports Server (NTRS)

    Takahashi, Y.; Wydeven, T.; Koo, C.

    1989-01-01

    A mixture of ammonium hydroxide with acetic acid and a slurry of human feces, urine, and wipes were used as CELSS model wastes to be wet-oxidized at temperatures from 250 to 500 C, i.e. below and above the critical point of water (374 C and 218 kg/sq cm or 21.4 MPa). The effects of oxidation temperature ( 250-500 C) and residence time (0-120 mn) on carbon and nitrogen and on metal corrosion from the reactor material were studied. Almost all of the organic matter in the model wastes was oxidized in the temperature range from 400 to 500 C, above the critical conditions for water. In contrast, only a small portion of the organic matter was oxidized at subcritical conditions. A substantial amount of nitrogen remained in solution in the form of ammonia at temperatures ranging from 350 to 450 C suggesting that, around 400 C, organic carbon is completely oxidized and most of the nitrogen is retained in solution. The Hastelloy C-276 alloy reactor corroded during subcritical and supercritical water oxidation.

  10. Cascades and cognitive state: focused attention incurs subcritical dynamics.

    PubMed

    Fagerholm, Erik D; Lorenz, Romy; Scott, Gregory; Dinov, Martin; Hellyer, Peter J; Mirzaei, Nazanin; Leeson, Clare; Carmichael, David W; Sharp, David J; Shew, Woodrow L; Leech, Robert

    2015-03-18

    The analysis of neuronal avalanches supports the hypothesis that the human cortex operates with critical neural dynamics. Here, we investigate the relationship between cascades of activity in electroencephalogram data, cognitive state, and reaction time in humans using a multimodal approach. We recruited 18 healthy volunteers for the acquisition of simultaneous electroencephalogram and functional magnetic resonance imaging during both rest and during a visuomotor cognitive task. We compared distributions of electroencephalogram-derived cascades to reference power laws for task and rest conditions. We then explored the large-scale spatial correspondence of these cascades in the simultaneously acquired functional magnetic resonance imaging data. Furthermore, we investigated whether individual variability in reaction times is associated with the amount of deviation from power law form. We found that while resting state cascades are associated with approximate power law form, the task state is associated with subcritical dynamics. Furthermore, we found that electroencephalogram cascades are related to blood oxygen level-dependent activation, predominantly in sensorimotor brain regions. Finally, we found that decreased reaction times during the task condition are associated with increased proximity to power law form of cascade distributions. These findings suggest that the resting state is associated with near-critical dynamics, in which a high dynamic range and a large repertoire of brain states may be advantageous. In contrast, a focused cognitive task induces subcritical dynamics, which is associated with a lower dynamic range, which in turn may reduce elements of interference affecting task performance. PMID:25788679

  11. Extraction of defatted rice bran with subcritical aqueous acetone.

    PubMed

    Chiou, Tai-Ying; Neoh, Tze Loon; Kobayashi, Takashi; Adachi, Shuji

    2012-01-01

    Defatted rice bran extracts were obtained by subcritical treatment using aqueous acetone as extractant. Treatment with 40% (v/v) acetone at 230 °C for 5 min yielded an extract with the highest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity (0.274 mmol of ascorbic acid/g of bran), total carbohydrate (0.188 g/g of bran), protein (0.512 g/g of bran), and total phenolic contents (88.2 mg of gallic acid/g of bran). The effect of treatment temperature (70-230 °C) was investigated using 40% (v/v) acetone, and the extract under 230 °C treatment showed the highest levels of all the determinations described above. The extracts obtained with various concentrations of aqueous acetone were subjected to UV absorption spectra and HPLC analysis, and the results showed changes in composition and polarity. Antioxidative activity evaluated against oxidation of bulk linoleic acid of the extract obtained with 80% (v/v) acetone was higher than that not only of the extract from subcritical water treatment but also of that obtained 40% (v/v) acetone treatment. PMID:22878207

  12. Study of subcritical flow through multiple-orifice valves

    SciTech Connect

    Surbey, D.W.; Kelkar, B.G.; Brill, J.P.

    1988-02-01

    Increased oil and gas production from offshore areas and hostile environments has led to a greater use of multiple-orifice-valve (MOV) wellhead chokes. Unlike conventional wellhead chokes, MOV's can be adjusted to any given choke area while under pressure, allowing wells in remote locations to be controlled from a central site. Data on the behavior of multiphase flow through MOV chokes have not been available in the past. This study investigated high-pressure (400 to 800 psia (2.8 to 5.5 MPa)), two-phase air/water flow through a 2-in. (5.1-cm) MOV choke. Single-phase air and water data were obtained to determine the valve-sizing coefficient, C/sub v/. A correlating parameter was determined with two-phase data to predict the subcritical two-phase pressure drop. This parameter was found to be a function of the gas/liquid ratio, upstream pressure, and choke opening. A mathematical model based on experimental observations was developed to predict the subcritical pressure drop across the choke for single-phase liquid flow.

  13. Sub-critical crack growth in a sheet of paper

    NASA Astrophysics Data System (ADS)

    Vanel, L.; Santucci, S.; Mallick, N.; Cortet, P.-P.; Roux, S. G.; Ciliberto, S.

    2007-03-01

    We present experiments on the slow growth of a single crack in a fax paper sheet submitted to a constant force F. The non-averaged crack growth curves present a stepwise growth dynamics. Modelling the material as a lattice where the crack is pinned by elastic traps and grows due to thermal noise, we find that, in agreement with experiments, the distribution of step sizes follows subcritical point statistics with a power law (exponent 3/2) and a stress-dependent exponential cutoff diverging at the critical rupture threshold [1]. Taking into account the microstructure of cellulose fibers, the model is able to reproduce the shape of the statistically averaged crack growth curves, the dependence of the characteristic growth length on F as well as the effect of temperature on the rupture time. Finally, roughness of the crack interface is shown to depend on whether the crack grows in the subcritical regime, or in the rapid regime, over the critical rupture threshold. We analyze this roughness difference using a new approach based on the cumulants of the statistical distribution of the crack front height variations. [1] S. Santucci, L. Vanel and S. Ciliberto, Phys. Rev. Lett. 93, 095505 (2004).

  14. Accelerated subcritical drying of large alkoxide silica gels

    NASA Astrophysics Data System (ADS)

    Wang, Shiho; Kirkbir, Fikret; Chaudhuri, S. R.; Sarkar, Arnab

    1992-12-01

    Fracture during drying has been the key hurdle in fabrication of large monolithic silica glass from alkoxide gels. Although existing literature suggests pore enlargement, aging, chemical additives, supercritical drying and freeze drying as helpful in avoiding fracture during drying, successful accelerated sub-critical drying of large silica monoliths from alkoxide gels has not yet been reported. In the present approach, acid catalyzed sols of TEOS, ethanol and water (pH equals 2) were cast as cylindrical rods in plastic molds of 8.0 and 10.0 cm diameter with volumes of 2000 cc and 3000 cc respectively. The resultant gels were aged for about 7 days and dried in a specially designed chamber under sub-critical conditions of the pore field. We have obtained monolithic dry gels in drying times of 3 - 7 days for sizes of 2000 - 3000 cc. The dry gels have narrow unimodal pore size distributions, with average pore radius of about 20 angstroms as measured by BET. Although capillary stress during drying increases with reduction of pore size, it was found that in this approach it is easier to dry gels of smaller pore size.

  15. Accelerator-induced transients in Accelerator Driven Subcritical Reactors

    NASA Astrophysics Data System (ADS)

    Ahmad, Ali; Lindley, Benjamin A.; Parks, Geoffrey T.

    2012-12-01

    Achieving higher particles energies and beam powers have long been the main focus of research in accelerator technology. Since Accelerator Driven Subcritical Reactors (ADSRs) have become the subject of increasing interest, accelerator reliability and modes of operation have become important matters that require further research and development in order to accommodate the engineering and economic needs of ADSRs. This paper focuses on neutronic and thermo-mechanical analyses of accelerator-induced transients in an ADSR. Such transients fall into three main categories: beam interruptions (trips), pulsed-beam operation, and beam overpower. The concept of a multiple-target ADSR is shown to increase system reliability and to mitigate the negative effects of beam interruptions, such as thermal cyclic fatigue in the fuel cladding and the huge financial cost of total power loss. This work also demonstrates the effectiveness of the temperature-to-reactivity feedback mechanisms in ADSRs. A comparison of shutdown mechanisms using control rods and beam cut-off highlights the intrinsic safety features of ADSRs. It is evident that the presence of control rods is crucial in an industrial-scale ADSR. This paper also proposes a method to monitor core reactivity online using the repetitive pattern of beam current fluctuations in a pulsed-beam operation mode. Results were produced using PTS-ADS, a computer code developed specifically to study the dynamic neutronic and thermal responses to beam transients in subcritical reactor systems.

  16. The safe, economical operation of a slightly subcritical reactor and transmutor with a small proton accelerator

    SciTech Connect

    Takahashi, Hiroshi

    1994-04-01

    This report describes methods in which an accelerator can be used to increase the safety and neutron economy of a power reactor and transmutor of long-lived radioactive wastes, such as minor actinides and fission products, by providing neutrons for its subcritical operation. Instead of the rather large subcriticality of k=0.9--0.95 which we originally proposed for such a transmutor, we propose to use a slightly subcritical reactor, such as k=0.99, which will avoid many of the technical difficulties that are associated with large subcriticality, such as localized power peaking, radiation damage due to the injection of medium-energy protons, the high current accelerator, and the requirement for a long beam-expansion section. We analyzed the power drop that occurred in Phoenix reactor, and show that the operating this reactor in subcritical condition improves its safety.

  17. Possibilities of post-mortem diagnostics, including immunodiagnostics, in cases of sudden death due to anaphylactic and anaphylactoid reactions.

    PubMed

    Kobek, M; Jankowski, Z; Chowaniec, C; Chowaniec, M; Jabłoński, C; Skowronek, R

    2014-01-01

    Postmortem diagnostics of anaphylactic and anaphylactoid reaction as the cause of death in cases of sudden deaths without witnesses, as well as those in which circumstances of sudden disease and then death are known, seems to be very difficult. This is caused by the lack of characteristic macro- or microscopic changes to internal organs resulting from a short, or even very short time, that elapses from the action of the etiological factor till death. In the above mentioned cases it is often impossible to establish univocally the cause of death, despite considering information on the cause of disease and its clinical symptoms. On the basis of 2 cases of sudden deaths resulted from the intake of hazel nuts, and the administration of contrast agent before radiological examination, the authors discuss the usefulness of postmortem determinations of tryptase and IgE in blood for diagnostics of deaths resulting from anaphylactic and anaphylactoid reaction, respectively. PMID:25574942

  18. Mathematical Speech and Practical Action: A Case Study of the Challenges of Including Mathematics in a School Technology Project

    ERIC Educational Resources Information Center

    Bungum, Berit; Manshadi, Saeed; Lysne, Dag Atle

    2014-01-01

    This paper presents a case study of how a teacher and nine-year-old students deal with mathematics in a practical technology project. By analysing videotaped dialogues between teacher and a pair of students working on constructing a house model, we identify challenges of meaningful inclusion of mathematics in the project. The dialogues are…

  19. Two Unexpected Tumors in a Laparoscopic Nephrectomy Specimen, Including a Rare Tubulocystic Renal-Cell Carcinoma: A Case Report

    PubMed Central

    Jipp, Jacob; Defrain, Chad; Schwartz, Bradley

    2015-01-01

    Abstract We present a case of a 52-year-old Caucasian male who underwent a laparoscopic nephrectomy for an atrophic kidney and was found to have two unexpected, synchronous kidney cancers. He had a remote history of testicular cancer complicated by lymphadenopathy and external ureteral compression. Over time, he developed an atrophic left kidney from obstructive uropathy. Years later, due to flank pain and renal scintigraphy showing minimal function, a laparoscopic nephrectomy was performed. Final pathology demonstrated papillary renal-cell carcinoma (RCC) and tubulocystic RCC. Tubulocystic RCC is a rare neoplasm thought to be an indolent subset of collecting duct carcinoma, but was identified as a unique entity in 2004. Currently, there are ∼100 cases of this neoplasm in the literature.

  20. Monitoring of MNSR operation by measuring subcritical photoneutron flux.

    PubMed

    Haddad, Kh; Alsomel, N

    2011-03-01

    Passive nondestructive assay methods are used to monitor the reactor's operation. It is required for nuclear regulatory, calculation validation and safeguards purposes. So, it plays a vital role in the safety and security of the nuclear plants. The possibility of MNSR operation monitoring by measuring the subcritical state photoneutron flux were investigated in this work. The photoneutron flux is induced by the fuels hard gamma radiation in the beryllium reflector. Theoretical formulation and experimental tests were performed. The results show that within a specified cooling time range, the photoneutron flux is induced by a single dominant hard gamma emitter such as (117)Cd (activation product) and (140)Ba ((140)La fission product). This phenomenon was utilized to monitor the cooling time and the operation neutron flux during the last campaign. Thus a passive nondestructive assay method is proposed with regard to the reactor operation's monitoring. PMID:21168337

  1. Glycolipid class profiling by packed-column subcritical fluid chromatography.

    PubMed

    Deschamps, Frantz S; Lesellier, Eric; Bleton, Jean; Baillet, Arlette; Tchapla, Alain; Chaminade, Pierre

    2004-06-18

    The potential of packed-column subcritical fluid chromatography (SubFC) for the separation of lipid classes has been assessed in this study. Three polar stationary phases were checked: silica, diol, and poly(vinyl alcohol). Carbon dioxide (CO2) with methanol as modifier was used as mobile phase and detection performed by evaporative light scattering detection. The influence of methanol content, temperature, and pressure on the chromatographic behavior of sphingolipids and glycolipids were investigated. A complete separation of lipid classes from a crude wheat lipid extract was achieved using a modifier gradient from 10 to 40% methanol in carbon dioxide. Solute selectivity was improved using coupled silica and diol columns in series. Because the variation of eluotropic strength depending on the fluid density changes, a normalized separation factor product (NSP) was used to select the nature, the number and the order of the columns to reach the optimum glycolipid separation. PMID:15248431

  2. Survey of aircraft subcritical flight flutter testing methods

    NASA Technical Reports Server (NTRS)

    Rosenbaum, R.

    1974-01-01

    The results of a survey of U. S., British and French subcritical aircraft flight flutter testing methods are presented and evaluation of the applicability of these methods to the testing of the space shuttle are discussed. Ten U. S. aircraft programs covering the large civil transport aircraft and a variety of military aircraft are reviewed. In addition, three major French and British programs are covered by the survey. The significant differences between the U. S., French and British practices in the areas of methods of excitation, data acquisition, transmission and analysis are reviewed. The effect of integrating the digital computer into the flight flutter test program is discussed. Significant saving in analysis and flight test time are shown to result from the use of special digital computer routines and digital filters.

  3. Intermittency in an optomechanical cavity near a subcritical Hopf bifurcation

    NASA Astrophysics Data System (ADS)

    Suchoi, Oren; Ella, Lior; Shtempluk, Oleg; Buks, Eyal

    2014-09-01

    We experimentally study an optomechanical cavity consisting of an oscillating mechanical resonator embedded in a superconducting microwave transmission line cavity. Tunable optomechanical coupling between the mechanical resonator and the microwave cavity is introduced by positioning a niobium-coated single-mode optical fiber above the mechanical resonator. The capacitance between the mechanical resonator and the coated fiber gives rise to optomechanical coupling, which can be controlled by varying the fiber-resonator distance. We study radiation-pressure-induced self-excited oscillation as a function of microwave driving parameters (frequency and power). Intermittency between limit-cycle and steady-state behaviors is observed with blue-detuned driving frequency. The experimental results are accounted for by a model that takes into account the Duffing-like nonlinearity of the microwave cavity. A stability analysis reveals a subcritical Hopf bifurcation near the region where intermittency is observed.

  4. Gravity-driven soap film dynamics in subcritical regimes

    NASA Astrophysics Data System (ADS)

    Auliel, M. I.; Castro, F.; Sosa, R.; Artana, G.

    2015-10-01

    We undertake the analysis of soap-film dynamics with the classical approach of asymptotic expansions. We focus our analysis in vertical soap film tunnels operating in subcritical regimes with elastic Mach numbers Me=O(10-1) . Considering the associated set of nondimensional numbers that characterize this flow, we show that the flow behaves as a two-dimensional (2D) divergence free flow with variable mass density. When the soap film dynamics agrees with that of a 2D and almost constant mass density flow, the regions where the second invariant of the velocity gradient is non-null correspond to regions where the rate of change of film thickness is non-negligible.

  5. Dynamic subcriticality measurements using the CF neutron noise method: Videotape

    SciTech Connect

    Mihalczo, J.T.; Blakeman, E.D.; Ragan, G.E.; Johnson, E.B.

    1987-01-01

    The capability to measure the subcriticality for a multiplying system with k-effective values as low as 0.3 was demonstrated for measurement times of approximately 10 s; the measured k-effective values obtained do not depend on the speed with which the solution height is changed or on whether the tank is filling or draining. As in previous experiments, the low-frequency ratios of spectral densities are all that are needed to obtain the k-effective value. This method's effectiveness for systems where conditions are changing with time as demonstrated, probably exceeds the dynamic requirements for most nuclear fuel plant processing applications. The calculated k-effective values using the KENO code and Hansen-Roach cross-sections compare well with the experimental values. Before the dynamic capability of the method can be considered fully explored, additional dynamic experiments are required for other geometries and fuel concentrations.

  6. Marginally subcritical dynamics explain enhanced stimulus discriminability under attention

    PubMed Central

    Tomen, Nergis; Rotermund, David; Ernst, Udo

    2014-01-01

    Recent experimental and theoretical work has established the hypothesis that cortical neurons operate close to a critical state which describes a phase transition from chaotic to ordered dynamics. Critical dynamics are suggested to optimize several aspects of neuronal information processing. However, although critical dynamics have been demonstrated in recordings of spontaneously active cortical neurons, little is known about how these dynamics are affected by task-dependent changes in neuronal activity when the cortex is engaged in stimulus processing. Here we explore this question in the context of cortical information processing modulated by selective visual attention. In particular, we focus on recent findings that local field potentials (LFPs) in macaque area V4 demonstrate an increase in γ-band synchrony and a simultaneous enhancement of object representation with attention. We reproduce these results using a model of integrate-and-fire neurons where attention increases synchrony by enhancing the efficacy of recurrent interactions. In the phase space spanned by excitatory and inhibitory coupling strengths, we identify critical points and regions of enhanced discriminability. Furthermore, we quantify encoding capacity using information entropy. We find a rapid enhancement of stimulus discriminability with the emergence of synchrony in the network. Strikingly, only a narrow region in the phase space, at the transition from subcritical to supercritical dynamics, supports the experimentally observed discriminability increase. At the supercritical border of this transition region, information entropy decreases drastically as synchrony sets in. At the subcritical border, entropy is maximized under the assumption of a coarse observation scale. Our results suggest that cortical networks operate at such near-critical states, allowing minimal attentional modulations of network excitability to substantially augment stimulus representation in the LFPs. PMID:25202240

  7. Subcritical-Water Extraction of Organics from Solid Matrices

    NASA Technical Reports Server (NTRS)

    Amashukeli, Xenia; Grunthaner, Frank; Patrick, Steven; Kirby, James; Bickler, Donald; Willis, Peter; Pelletier, Christine; Bryson, Charles

    2009-01-01

    An apparatus for extracting organic compounds from soils, sands, and other solid matrix materials utilizes water at subcritical temperature and pressure as a solvent. The apparatus, called subcritical water extractor (SCWE), is a prototype of subsystems of future instrumentation systems to be used in searching for organic compounds as signs of past or present life on Mars. An aqueous solution generated by an apparatus like this one can be analyzed by any of a variety of established chromatographic or spectroscopic means to detect the dissolved organic compound( s). The apparatus can be used on Earth: indeed, in proof-of-concept experiments, SCWE was used to extract amino acids from soils of the Atacama Desert (Chile), which was chosen because the dryness and other relevant soil conditions there approximate those on Mars. The design of the apparatus is based partly on the fact that the relative permittivity (also known as the dielectric constant) of liquid water varies with temperature and pressure. At a temperature of 30 C and a pressure of 0.1 MPa, the relative permittivity of water is 79.6, due to the strong dipole-dipole electrostatic interactions between individual molecular dipoles. As the temperature increases, increasing thermal energy causes increasing disorientation of molecular dipoles, with a consequent decrease in relative permittivity. For example, water at a temperature of 325 C and pressure of 20 MPa has a relative permittivity of 17.5, which is similar to the relative permittivities of such nonpolar organic solvents as 1-butanol (17.8). In the operation of this apparatus, the temperature and pressure of water are adjusted so that the water can be used in place of commonly used organic solvents to extract compounds that have dissimilar physical and chemical properties.

  8. Subcritical Water Extraction of Amino Acids from Atacama Desert Soils

    NASA Technical Reports Server (NTRS)

    Amashukeli, Xenia; Pelletier, Christine C.; Kirby, James P.; Grunthaner, Frank J.

    2007-01-01

    Amino acids are considered organic molecular indicators in the search for extant and extinct life in the Solar System. Extraction of these molecules from a particulate solid matrix, such as Martian regolith, will be critical to their in situ detection and analysis. The goals of this study were to optimize a laboratory amino acid extraction protocol by quantitatively measuring the yields of extracted amino acids as a function of liquid water temperature and sample extraction time and to compare the results to the standard HCl vapor- phase hydrolysis yields for the same soil samples. Soil samples from the Yungay region of the Atacama Desert ( Martian regolith analog) were collected during a field study in the summer of 2005. The amino acids ( alanine, aspartic acid, glutamic acid, glycine, serine, and valine) chosen for analysis were present in the samples at concentrations of 1 - 70 parts- per- billion. Subcritical water extraction efficiency was examined over the temperature range of 30 - 325 degrees C, at pressures of 17.2 or 20.0 MPa, and for water- sample contact equilibration times of 0 - 30 min. None of the amino acids were extracted in detectable amounts at 30 degrees C ( at 17.2 MPa), suggesting that amino acids are too strongly bound by the soil matrix to be extracted at such a low temperature. Between 150 degrees C and 250 degrees C ( at 17.2 MPa), the extraction efficiencies of glycine, alanine, and valine were observed to increase with increasing water temperature, consistent with higher solubility at higher temperatures, perhaps due to the decreasing dielectric constant of water. Amino acids were not detected in extracts collected at 325 degrees C ( at 20.0 MPa), probably due to amino acid decomposition at this temperature. The optimal subcritical water extraction conditions for these amino acids from Atacama Desert soils were achieved at 200 degrees C, 17.2 MPa, and a water- sample contact equilibration time of 10 min.

  9. [Four cases of 5-fluorouracil-related hyperammonemia in patients with large intestinal cancer and multiple liver metastases, including a case of hyperammonemia treated using hemodialysis].

    PubMed

    Iida, Tomoya; Wagatsuma, Kohei; Tani, Motohiro; Sasaki, Hajime; Naganawa, Yumiko; Isshiki, Hiroyuki; Murakami, Kayo; Satoh, Shuji; Shimizu, Haruo; Kaneto, Hiroyuki

    2015-02-01

    Systemic chemotherapy based on 5-fluorouracil (5-FU) is a standard treatment for unresectable or recurrent large intestinal cancer. Although hyperammonemia is a known side effect of 5-FU that can cause serious pathological conditions, only a few cases have been reported. We describe 4 cases of 5-FU-related hyperammonemia with impairment of consciousness in patients who received 5-FU chemotherapy for large intestinal cancer with multiple liver metastases. Hemodialysis was effective in 1 severe case. There have been no detailed reports on the use of hemodialysis for hyperammonemia caused by 5-FU. Renal dysfunction is considered to be a risk factor for hyperammonemia caused by 5-FU and it is necessary to pay particular attention in patients with renal dysfunction who receive chemotherapy with 5-FU. Here we summarize our cases together with 16 previously reported cases of hyperammonemia caused by 5-FU in Japan. PMID:25748155

  10. Including Ideology

    ERIC Educational Resources Information Center

    Allan, Julie

    2013-01-01

    Ellen Brantlinger's paper, "Using ideology: cases of non-recognition of the politics of research and practice in special education" (Brantlinger, E. 1997. "Using ideology: Cases of nonrecognition of the politics of research and practice in special education." "Review of Educational Research" 67, no. 4: 425-59),…

  11. Post-kala-azar Dermal Leishmaniasis with Mucosal Involvement: An Unusual Case Presentation including Successful Treatment with Miltefosine

    PubMed Central

    Siddiqui, Muhammad A.; Nabi, Shah G.; Bhaskar, Khondaker R.H.; Mondal, Dinesh

    2013-01-01

    Post-kala-azar dermal leishmaniasis (PKDL) is a dermatologic manifestation that usually occurs after visceral leishmaniasis (VL) caused by Leishmania donovani. It is characterized by hypopigmented patches, a macular or maculopapular rash and nodular skin lesions on the body surface. Involvement of the mucosae is very rare and unusual in PKDL. We report a case of PKDL that presented with polymorphic skin lesions, along with involvement of peri-oral mucosa and tongue from an endemic area for kala-azar in Bangladesh. In the absence of a definite past history of kala-azar, a clinical suspicion for PKDL was confirmed by positive rapid serological tests against two recombinant (rK39 and rK28) leishmanial antigens, demonstration of Leishmania donovani (LD) body in the slit skin smear, and isolation of promastigotes by culture from a nodular lesion. The patient was treated with oral Miltefosine for three consecutive months and showed significant clinical improvement as demonstrated by a negative slit skin smear at two months after initiation of therapy. We report this case as an unusual presentation of mucosal involvement in PKDL and subsequent treatment success with Miltefosine. PMID:23930349

  12. The Subcritical Assembly in Dubna (SAD)—Part II: Research program for ADS-demo experiment

    NASA Astrophysics Data System (ADS)

    Gudowski, Waclaw; Shvetsov, Valery; Polanski, Aleksander; Broeders, Cornelis

    2006-06-01

    Subcritical Assembly in Dubna (SAD), a project funded by the International Science and Technology Centre, driven in collaboration with many European partners, may become the first Accelerator Driven Subcritical experiment coupling an existing proton accelerator of 660 MeV with a compact MQX-fuelled subcritical core. The main objective of the SAD experiment is to study physics of Accelerator Driven System ranging from a very deep subcriticality up to keff of 0.98. All experiences with subcriticality monitoring from previous subcritical experiments like MUSE, Yalina and IBR-30 booster mode will be verified in order to select the most reliable subcriticality monitoring technique. Particular attention will be given to validation of the core power-beam current relation. Moreover, some studies have been done to assess possibility of power upgrade for SAD.

  13. PRKAR1A in the development of cardiac myxoma: a study of 110 cases including isolated and syndromic tumors.

    PubMed

    Maleszewski, Joseph J; Larsen, Brandon T; Kip, Nefize Sertac; Castonguay, Mathieu C; Edwards, William D; Carney, J Aidan; Kipp, Benjamin R

    2014-08-01

    Cardiac myxoma usually occurs as a solitary mass, but occasionally develops as part of a familial syndrome, the Carney complex (CNC). Two thirds of CNC-associated cardiac myxomas exhibit mutations in PRKAR1A. PRKAR1A mutations occur in both familial and sporadic forms of CNC but have not been described in isolated (nonsyndromic) cardiac myxomas. A total of 127 consecutive cardiac myxomas surgically resected at Mayo Clinic (1993 to 2011) from 110 individuals were studied. Clinical, radiologic, and pathologic findings were reviewed. Of these, 103 patients had isolated cardiac myxomas, and 7 patients had the tumor as a component of CNC. Age and sex distributions were different for CNC (mean 26 y, range 14 to 44 y, 71% female) and non-CNC (mean 62 y, range 18 to 92 y, 63% female) patients. PRKAR1A immunohistochemical analysis (IHC) was performed, and myxoma cell reactivity was graded semiquantitatively. Bidirectional Sanger sequencing was performed in 3 CNC patients and 29 non-CNC patients, to test for the presence of mutations in all coding regions and intron/exon boundaries of the PRKAR1A gene. IHC staining showed that all 7 CNC cases lacked PRKAR1A antigenicity and that 33 (32%) isolated cardiac myxomas were similarly nonreactive. Of tumors subjected to sequencing analysis, 2 (67%) CNC myxomas and 9 (31%) non-CNC myxomas had pathogenic PRKAR1A mutations. No germline mutations were found in 4 non-CNC cases tested. PRKAR1A appears to play a role in the development of both syndromic and nonsyndromic cardiac myxomas. Routine IHC evaluation of cardiac myxomas for PRKAR1A expression may be useful in excluding a diagnosis of CNC. PMID:24618615

  14. Case studies on recent fossil-fired plants

    SciTech Connect

    Henderson, C.

    2007-12-31

    The article summarises the findings of case studies on fossil-fired power plants carried out by the IEA Clean Coal Centre for the IEA at the request of world leaders at the Gleneagles G8 Summit in July 2005. The studies compared the cost, efficiency and emissions of eight recently constructed coal-fired plants using pulverized coal combustion with subcritical, supercritical or ultra-supercritical steam turbine cycles. Also included was a review of IGCC developments. A case study of a natural gas combined-cycle plant was included for comparison. The full report has been published by the IEA. 1 tab.

  15. Building a Generation of Physician Advocates: The Case for Including Mandatory Training in Advocacy in Canadian Medical School Curricula.

    PubMed

    Bhate, Tahara D; Loh, Lawrence C

    2015-12-01

    There is an increasing focus on the social accountability of physicians as individuals, and of medicine itself. This has led to increasing emphasis on physician advocacy from a wide variety of institutions. The physician advocacy concept is now part of the Health Advocacy competency mandated by the Royal College of Physicians and Surgeons of Canada. Despite its growing prominence, physician advocacy remains poorly integrated into current medical undergraduate curricula. The authors recommend how and why curricular reform should proceed; they focus on Canadian medical education, although they hope their views will be useful in other countries as well.The authors discuss conflicting definitions of physician advocacy, which have previously hampered curriculum development efforts, and suggest a way of reconciling the conflicts. They review current gaps in advocacy-related curricula, suggest that these can be addressed by incorporating practice-based and skills acquisition elements into current didactic teaching, and offer several strategies by which an advocacy curriculum could be implemented, ranging from small modifications to current curriculum to developing new competencies in medical education nationally.The authors present a case for making an advocacy curriculum mandatory for every Canadian medical trainee; they argue that teaching trainees how to fulfill their professional responsibility to advocate may also help them meet the social accountability mandate of medical school education. Finally, the authors explain why making the development and implementation of a mandatory, skill-based curriculum in advocacy should be a priority. PMID:26200573

  16. Mathematical speech and practical action: a case study of the challenges of including mathematics in a school technology project

    NASA Astrophysics Data System (ADS)

    Bungum, Berit; Manshadi, Saeed; Atle Lysne, Dag

    2014-11-01

    This paper presents a case study of how a teacher and nine-year-old students deal with mathematics in a practical technology project. By analysing videotaped dialogues between teacher and a pair of students working on constructing a house model, we identify challenges of meaningful inclusion of mathematics in the project. The dialogues are analysed in terms of an analytical framework where four categories of interaction patterns are combined with two main paradigms of mathematics teaching: the exercise paradigm and landscapes of interaction. The project in itself has a potential for facilitating landscapes of investigation in mathematics teaching. However, we find that the teacher as well as students adheres to the exercise paradigm when mathematics is involved in the activity. Two illustrating episodes from the project are examined and presented in detail in this paper. The findings illustrate that the conceptions teachers and students hold of what mathematics teaching means can act as an obstacle in attempts to realize mathematics teaching in creative and meaningful contexts for young students. We suggest that making the various purposes of a project more explicit may help overcome this obstacle, and that the mathematics involved might be taught in separate sessions in order to form a constructive part of a cross-curricular project.

  17. Subcritical crack growth in a chemically reactive environment-implications for caprock integrity for CO2 storage

    NASA Astrophysics Data System (ADS)

    Fan, Z.; Eichhubl, P.; Callahan, O. A.; Major, J. R.; Chen, X.

    2015-12-01

    Seal integrity of cap-rock is a critical constraint on the long term performance of CO2 containment site. During fluid migration, the coupled geochemical reaction of minerals and geomechanical deformation of rock matrix may affect the seal integrity. The potential leakage of injected CO2 from cap-rock through preexisting fractures/faults represents a major concern associated with geological storage of CO2. To address the fundamental question of CO2 leakage through subcritical growth of fractures driven by chemically reactive fluid across caprocks, we build a Dugdale cohesive model. Ahead of the physical crack tip, a narrow band of cohesive zone is assumed to exist with the upper and lower cohesive surfaces held by the cohesive traction. In the vicinity of the crack tip, minerals dissolve due to the acidic environment and migrate from the physical crack tip into the cohesive zone causing damage of rock matrix in the form of a reduction of cohesive traction.Focusing on the dissolution of calcite and following the stress corrosion theory, we assume the degradation of cohesive traction is linearly proportional to the concentration of Ca2+whose evolution follows the reactive diffusion equation. Using a critical crack opening displacement criterion, the subcritical propagation behavior of crack due to stress corrosion is captured and the rate-limiting effects including the chemical reactions to produce the Ca2+ and the transport of minerals along the newly generated fracture cohesive zone are incorporated. Subcritical crack growth rate under different chemical environment conditions is examined and compared with the experimental fracture mechanics testing.

  18. Integrated wastewater management reporting at tourist areas for recycling purposes, including the case study of Hersonissos, Greece.

    PubMed

    Borboudaki, K E; Paranychianakis, N V; Tsagarakis, K P

    2005-10-01

    Wastewater treatment facilities in tourist areas, in comparison to other municipal facilities, require specific configurations and additional management actions in order to achieve a reliable and cost-effective treatment. For example, the same facility operates during winter with minimum flows and in summer with peak flows. Moreover, careful effluent management is required to minimize environmental impact and health effects on tourists. In this study, effluent management data, including quantitative and qualitative effluent characteristics, reuse, and economic aspects of the Hersonissos Wastewater Treatment Plant (WTP) in Greece, are discussed. It has been designed to treat both municipal wastewater from the Hersonissos Municipality and septage from the wider area. Analysis of effluent quantitative data showed two flow peaks in the summer period and only one in winter. The WTP was found to provide a reliable level of treatment in terms of biochemical oxygen demand (95.9%), total suspended solids (97.2%), and total nitrogen (87.7%) removal, but increased numbers of fecal coliforms were measured at some peak flow periods, suggesting the need for additional management strategies. Effluent is reused mainly for agricultural irrigation; secondary uses include fire protection and landscape irrigation. Economic analysis showed that for each cubic meter treated, the total annual economic cost for treatment, filtration, and reuse infrastructure was 1.07 euro, 0.05 euro, and 0.08 euro, respectively. PMID:16222463

  19. Including the urban heat island in spatial heat health risk assessment strategies: a case study for Birmingham, UK

    PubMed Central

    2011-01-01

    Background Heatwaves present a significant health risk and the hazard is likely to escalate with the increased future temperatures presently predicted by climate change models. The impact of heatwaves is often felt strongest in towns and cities where populations are concentrated and where the climate is often unintentionally modified to produce an urban heat island effect; where urban areas can be significantly warmer than surrounding rural areas. The purpose of this interdisciplinary study is to integrate remotely sensed urban heat island data alongside commercial social segmentation data via a spatial risk assessment methodology in order to highlight potential heat health risk areas and build the foundations for a climate change risk assessment. This paper uses the city of Birmingham, UK as a case study area. Results When looking at vulnerable sections of the population, the analysis identifies a concentration of "very high" risk areas within the city centre, and a number of pockets of "high risk" areas scattered throughout the conurbation. Further analysis looks at household level data which yields a complicated picture with a considerable range of vulnerabilities at a neighbourhood scale. Conclusions The results illustrate that a concentration of "very high" risk people live within the urban heat island, and this should be taken into account by urban planners and city centre environmental managers when considering climate change adaptation strategies or heatwave alert schemes. The methodology has been designed to be transparent and to make use of powerful and readily available datasets so that it can be easily replicated in other urban areas. PMID:21682872

  20. Comparing methods for estimating R0 from the size distribution of subcritical transmission chains

    PubMed Central

    Blumberg, S.; Lloyd-Smith, J.O.

    2013-01-01

    Many diseases exhibit subcritical transmission (i.e. 0 < R0 < 1) so that infections occur as self-limited ‘stuttering chains’. Given an ensemble of stuttering chains, information about the number of cases in each chain can be used to infer R0, which is of crucial importance for monitoring the risk that a disease will emerge to establish endemic circulation. However, the challenge of imperfect case detection has led authors to adopt a variety of work-around measures when inferring R0, such as discarding data on isolated cases or aggregating intermediate-sized chains together. Each of these methods has the potential to introduce bias, but a quantitative comparison of these approaches has not been reported. By adapting a model based on a negative binomial offspring distribution that permits a variable degree of transmission heterogeneity, we present a unified analysis of existing R0 estimation methods. Simulation studies show that the degree of transmission heterogeneity, when improperly modeled, can significantly impact the bias of R0 estimation methods designed for imperfect observation. These studies also highlight the importance of isolated cases in assessing whether an estimation technique is consistent with observed data. Analysis of data from measles outbreaks shows that likelihood scores are highest for models that allow a flexible degree of transmission heterogeneity. Aggregating intermediate sized chains often has similar performance to analyzing a complete chain size distribution. However, truncating isolated cases is beneficial only when surveillance systems clearly favor full observation of large chains but not small chains. Meanwhile, if data on the type and proportion of cases that are unobserved were known, we demonstrate that maximum likelihood inference of R0 could be adjusted accordingly. This motivates the need for future empirical and theoretical work to quantify observation error and incorporate relevant mechanisms into stuttering chain

  1. Endodontic Management of Maxillary First Molar with Five Root Canals, Including Two Distobuccal Root Canals: A Case Report.

    PubMed

    Sinha, Dakshita Joy; Sinha, Ashish Amit; Prakash, Prem; Jaiswal, Natasha

    2016-01-01

    Multiple canals in the root are part of the normal morphology of the tooth. A canal may sometimes be overlooked, however, and this may lead to failure of treatment. The first step in successful endodontic treatment, therefore, is gaining access to the pulp chamber and locating all the canals. In order to achieve this goal, practitioners need to be familiar with all possible variations in root canal morphology, and should thoroughly explore roots to ensure that all canals are identified, debrided, and obturated. Here, we report the diagnosis, treatment planning, and endodontic management of a maxillary first molar with five root canals, including two distobuccal root canals, in a 22-year-old woman. PMID:26961335

  2. Development of a computer algorithm for the analysis of variable-frequency AC drives: Case studies included

    NASA Technical Reports Server (NTRS)

    Kankam, M. David; Benjamin, Owen

    1991-01-01

    The development of computer software for performance prediction and analysis of voltage-fed, variable-frequency AC drives for space power applications is discussed. The AC drives discussed include the pulse width modulated inverter (PWMI), a six-step inverter and the pulse density modulated inverter (PDMI), each individually connected to a wound-rotor induction motor. Various d-q transformation models of the induction motor are incorporated for user-selection of the most applicable model for the intended purpose. Simulation results of selected AC drives correlate satisfactorily with published results. Future additions to the algorithm are indicated. These improvements should enhance the applicability of the computer program to the design and analysis of space power systems.

  3. Burnup calculations for KIPT accelerator driven subcritical facility using Monte Carlo computer codes-MCB and MCNPX.

    SciTech Connect

    Gohar, Y.; Zhong, Z.; Talamo, A.; Nuclear Engineering Division

    2009-06-09

    Argonne National Laboratory (ANL) of USA and Kharkov Institute of Physics and Technology (KIPT) of Ukraine have been collaborating on the conceptual design development of an electron accelerator driven subcritical (ADS) facility, using the KIPT electron accelerator. The neutron source of the subcritical assembly is generated from the interaction of 100 KW electron beam with a natural uranium target. The electron beam has a uniform spatial distribution and electron energy in the range of 100 to 200 MeV. The main functions of the subcritical assembly are the production of medical isotopes and the support of the Ukraine nuclear power industry. Neutron physics experiments and material structure analyses are planned using this facility. With the 100 KW electron beam power, the total thermal power of the facility is {approx}375 kW including the fission power of {approx}260 kW. The burnup of the fissile materials and the buildup of fission products reduce continuously the reactivity during the operation, which reduces the neutron flux level and consequently the facility performance. To preserve the neutron flux level during the operation, fuel assemblies should be added after long operating periods to compensate for the lost reactivity. This process requires accurate prediction of the fuel burnup, the decay behavior of the fission produces, and the introduced reactivity from adding fresh fuel assemblies. The recent developments of the Monte Carlo computer codes, the high speed capability of the computer processors, and the parallel computation techniques made it possible to perform three-dimensional detailed burnup simulations. A full detailed three-dimensional geometrical model is used for the burnup simulations with continuous energy nuclear data libraries for the transport calculations and 63-multigroup or one group cross sections libraries for the depletion calculations. Monte Carlo Computer code MCNPX and MCB are utilized for this study. MCNPX transports the

  4. A streamline curvature method for design of supercritical and subcritical airfoils

    NASA Technical Reports Server (NTRS)

    Barger, R. L.; Brooks, C. W., Jr.

    1974-01-01

    An airfoil design procedure, applicable to both subcritical and supercritical airfoils, is described. The method is based on the streamline curvature velocity equation. Several examples illustrating this method are presented and discussed.

  5. SELECTIVE EXTRACTION OF OXYGENATES FROM SAVORY AND PEPPERMINT USING SUBCRITICAL WATER. (R825394)

    EPA Science Inventory

    The yields of oxygenated and non-oxygenated flavour and fragrance compounds from savory (Satureja hortensis) and peppermint (Mentha piperita) were compared using subcritical water extraction, supercritical carbon dioxide extraction (SFE) and hydrodistillation. Extraction rates wi...

  6. Supercritical (and Subcritical) Fluid Behavior and Modeling: Drops, Streams, Shear and Mixing Layers, Jets and Sprays

    NASA Technical Reports Server (NTRS)

    Bellan, J.

    1999-01-01

    A critical review of recent investigations in the real of supercritical (and subcritical) fluid behavior is presented with the goal of obtaining a perspective on the peculiarities of high pressure observations.

  7. Including impacts of particulate emissions on marine ecosystems in life cycle assessment: the case of offshore oil and gas production.

    PubMed

    Veltman, Karin; Huijbregts, Mark A J; Rye, Henrik; Hertwich, Edgar G

    2011-10-01

    Life cycle assessment is increasingly used to assess the environmental performance of fossil energy systems. Two of the dominant emissions of offshore oil and gas production to the marine environment are the discharge of produced water and drilling waste. Although environmental impacts of produced water are predominantly due to chemical stressors, a major concern regarding drilling waste discharge is the potential physical impact due to particles. At present, impact indicators for particulate emissions are not yet available in life cycle assessment. Here, we develop characterization factors for 2 distinct impacts of particulate emissions: an increased turbidity zone in the water column and physical burial of benthic communities. The characterization factor for turbidity is developed analogous to characterization factors for toxic impacts, and ranges from 1.4 PAF (potentially affected fraction) · m(3) /d/kg(p) (kilogram particulate) to 7.0 x 10³ [corrected] for drilling mud particles discharged from the rig. The characterization factor for burial describes the volume of sediment that is impacted by particle deposition on the seafloor and equals 2.0 × 10(-1) PAF · m(3) /d/kg(p) for cutting particles. This characterization factor is quantified on the basis of initial deposition layer characteristics, such as height and surface area, the initial benthic response, and the recovery rate. We assessed the relevance of including particulate emissions in an impact assessment of offshore oil and gas production. Accordingly, the total impact on the water column and on the sediment was quantified based on emission data of produced water and drilling waste for all oil and gas fields on the Norwegian continental shelf in 2008. Our results show that cutting particles contribute substantially to the total impact of offshore oil and gas production on marine sediments, with a relative contribution of 55% and 31% on the regional and global scale, respectively. In contrast, the

  8. Super- and sub-critical regions in shocks driven by radio-loud and radio-quiet CMEs

    NASA Astrophysics Data System (ADS)

    Bemporad, Alessandro; Mancuso, Salvatore

    2013-05-01

    White-light coronagraphic images of Coronal Mass Ejections (CMEs) observed by SOHO/LASCO C2 have been used to estimate the density jump along the whole front of two CME-driven shocks. The two events are different in that the first one was a "radio-loud" fast CME, while the second one was a "radio quiet" slow CME. From the compression ratios inferred along the shock fronts, we estimated the Alfvén Mach numbers for the general case of an oblique shock. It turns out that the "radio-loud" CME shock is initially super-critical around the shock center, while later on the whole shock becomes sub-critical. On the contrary, the shock associated with the "radio-quiet" CME is sub-critical at all times. This suggests that CME-driven shocks could be efficient particle accelerators at the shock nose only at the initiation phases of the event, if and when the shock is super-critical, while at later times they lose their energy and the capability to accelerate high energetic particles.

  9. Target normal sheath acceleration of foil ions by laser-trapped hot electrons from a long subcritical-density preplasma

    SciTech Connect

    Luan, S. X.; Yu, Wei; Shen, B. F.; Xu, Z. Z.; Yu, M. Y.; Zhuo, H. B.; Xu, Han; Wong, A. Y.; Wang, J. W.

    2014-12-15

    In a long subcritical density plasma, an ultrashort ultraintense laser pulse can self-organize into a fast but sub-relativistic propagating structure consisting of the modulated laser light and a large number of trapped electrons from the plasma. Upon impact of the structure with a solid foil target placed in the latter, the remaining laser light is reflected, but the dense and hot trapped electrons pass through the foil, together with the impact-generated target-frontsurface electrons to form a dense hot electron cloud at the back of the target suitable for enhancing target normal sheath acceleration of the target-backsurface ions. The accelerated ions are well collimated and of high charge and energy densities, with peak energies a full order of magnitude higher than that from target normal sheath acceleration without the subcritical density plasma. In the latter case, the space-charge field accelerating the ions is limited since they are formed only by the target-frontsurface electrons during the very short instant of laser reflection.

  10. Super- and subcritical turbidity currents and their deposits - a synthesis

    NASA Astrophysics Data System (ADS)

    Postma, George; Cartigny, Matthieu

    2014-05-01

    Popular facies schemes of turbidite deposits presently in use are based on an idealized sequence of turbidite units, such as those erected by Bouma (1962) and Lowe (1982). We discuss here that such approach is flawed, because these idealized sequences do not reveal the spectrum of bedforms produced by supercritical turbidity currents (TCs) that are now found to be common on slopes steeper than 0.6 degrees, i.e. on slopes of deepwater deltas, in canyons, and in confinement of supra-lobe channels. This paper shows and discusses how 'problematic' thick successions comprising structureless and crudely stratified deposits (top-cut out Bouma sequences) in conjunction with scours filled with backset stratification and Bouma Ta are specifically related to bedforms formed by high density super critical flows. It will also be shown that thick tabular and straight beds with Bouma Tb3-1, Tc, Tde, which are possibly linked with debrites (hybrid flows) and often traceable over long km distances (see Haugthon et al. 2009 and Tjalling et al. 2012) can be related to high-density subcritical flows. The ability to infer large-scale dynamics of turbidity currents from deposits allows rough estimates of slope on a basinal scale, and allows better differentiation and prediction of facies in sub-environments such as channel - lobe transitions, where supercritical confined flow transforms into subcritical flows. It will also aid modellers to better relate turbidite deposits with flow dynamics. The linking of turbidite units to large-scale flow dynamics resolves process-facies links that were hitherto unresolved in the Bouma sequence. References: Bouma, A.H. (1962) Sedimentology of Some Flysch Deposits: a Graphic Approach to Facies Interpretation. Elsevier, Amsterdam. 168 pp. Haughton, P.D.W., Davis, C., McCaffrey, W. and Barker, S.P. (2009) Hybrid sediment gravity flow deposits - classification, origin and significance. In: Hybrid and Transitional Submarine Flows (Eds. L.A. Amy, W.B. Mc

  11. Stability and activity of lipase in subcritical 1,1,1,2-tetrafluoroethane (R134a).

    PubMed

    Yu, Gang; Xue, Yong; Xu, Wei; Zhang, Jing; Xue, Chang Hu

    2007-12-01

    The stability and activity of commercial immobilized lipase from Candida antarctica (Novozym 435) in subcritical 1,1,1,2-tetrafluoroethane (R134a) was investigated. The esterification of oleic acid with glycerol was studied as a model reaction in subcritical R134a and in solvent-free conditions. The results indicated that subcritical R134a treatment led to significant increase of activity of Novozym 435, and a maximum residual activity of 300% was measured at 4 MPa, 30 degrees C after 7 h incubation. No deactivation of Novozym 435 treated with subcritical R134a under different operation factors (pressure 2-8 MPa, temperature 30-60 degrees C, incubation time 1-12 h, water content 1:1, 1:2, 1:5 enzyme/water, depressurization rate 4 MPa/1 min, 4 MPa/30 min, 4 MPa/90 min) was observed. While the initial reaction rate was high in subcritical R134a, higher conversion was obtained in solvent-free conditions. Though the apparent conversion of the reaction is lower in subcritical R134a, it is more practicable, especially at low enzyme concentrations desired at commercial scales. PMID:17909872

  12. Subcritical Noise Analysis Measurements with Fresh and Spent Research Reactor Fuels Elements

    SciTech Connect

    Valentine, T.E.; Mihalczo, J.T.; Kryter, R.C.; Miller, V.C.

    1999-02-01

    The verification of the subcriticality is of utmost importance for the safe transportation and storage of nuclear reactor fuels. Transportation containers and storage facilities are designed such that nuclear fuels remain in a subcritical state. Such designs often involve excess conservatism because of the lack of relevant experimental data to verify the accuracy of Monte Carlo codes used in nuclear criticality safety analyses. A joint experimental research program between Oak Ridge National Laboratory, Westinghouse Safety Management Solutions, Inc., and the University of Missouri was initiated to obtain measured quantities that could be directly related to the subcriticality of simple arrays of Missouri University Research Reactor (MURR) fuel elements. A series of measurement were performed to assess the reactivity of materials such as BORAL, stainless steel, aluminum, and lead that are typically used in the construction of shipping casks. These materials were positioned between the fuel elements. In addition, a limited number of measurements were performed with configurations of fresh and spent (irradiated) fuel elements to ascertain the reactivity of the spent fuel elements. In these experiments, fresh fuel elements were replaced by spent fuel elements such that the subcritical reactivity change could be measured. The results of these measurements were used by Westinghouse Safety Management Solutions to determine the subcriticality of MURR fuel elements isolated by absorbing materials. The measurements were interpreted using the MCNP-DSP Monte Carlo code to obtain the subcritical neutron multiplication factor k(sub eff), and the bias in K(sub eff) that are used in criticality safety analyses.

  13. Experimental subcritical facility driven by D-D/D-T neutron generator at BARC, India

    NASA Astrophysics Data System (ADS)

    Sinha, Amar; Roy, Tushar; Kashyap, Yogesh; Ray, Nirmal; Shukla, Mayank; Patel, Tarun; Bajpai, Shefali; Sarkar, P. S.; Bishnoi, Saroj

    2015-05-01

    The paper presents design of an experimental subcritical assembly driven by D-D/D-T neutron and preliminary experimental measurements. The system has been developed for investigating the static and dynamic neutronic properties of accelerator driven sub-critical systems. This system is modular in design and it is first in the series of subcritical assemblies being designed. The subcritical core consists of natural uranium fuel with high density polyethylene as moderator and beryllium oxide as reflector. The fuel is embedded in high density polyethylene moderator matrix. Estimated keff of the system is ∼0.89. One of the unique features of subcritical core is the use of Beryllium oxide (BeO) as reflector and HDPE as moderator making the assembly a compact modular system. The subcritical core is coupled to Purnima Neutron Generator which works in D-D and D-T mode with both DC and pulsed operation. It has facility for online source strength monitoring using neutron tagging and programmable source modulation. Preliminary experiments have been carried out for spatial flux measurement and reactivity estimation using pulsed neutron source (PNS) techniques with D-D neutrons. Further experiments are being planned to measure the reactivity and other kinetic parameters using noise methods. This facility would also be used for carrying out studies on effect of source importance and measurement of source multiplication factor ks and external neutron source efficiency φ∗ in great details. Experiments with D-T neutrons are also underway.

  14. Life cycle assessment of biodiesel production from algal bio-crude oils extracted under subcritical water conditions.

    PubMed

    Ponnusamy, Sundaravadivelnathan; Reddy, Harvind Kumar; Muppaneni, Tapaswy; Downes, Cara Meghan; Deng, Shuguang

    2014-10-01

    A life cycle assessment study is performed for the energy requirements and greenhouse gas emissions in an algal biodiesel production system. Subcritical water (SCW) extraction was applied for extracting bio-crude oil from algae, and conventional transesterification method was used for converting the algal oil to biodiesel. 58MJ of energy is required to produce 1kg of biodiesel without any co-products management, of which 36% was spent on cultivation and 56% on lipid extraction. SCW extraction with thermal energy recovery reduces the energy consumption by 3-5 folds when compared to the traditional solvent extraction. It is estimated that 1kg of algal biodiesel fixes about 0.6kg of CO2. An optimized case considering the energy credits from co-products could further reduce the total energy demand. The energy demand for producing 1kg of biodiesel in the optimized case is 28.23MJ. PMID:25164337

  15. Droplet-turbulence interactions in subcritical and supercritical evaporating sprays

    NASA Technical Reports Server (NTRS)

    Santavicca, Domenic A.; Coy, Edward; Greenfield, Stuart; Song, Young-Hoon

    1991-01-01

    The objective of this research is to obtain an improved understanding of droplet turbulence interactions in vaporizing liquid sprays under conditions typical of those encountered in liquid fueled rocket engines. The interaction between liquid droplets and the surrounding turbulent gas flow affects droplet dispersion, droplet collisions, droplet vaporization and gas-phase, fuel-oxidant mixing, and therefore has a significant effect on the engine's combustion characteristics. An example of this is the role which droplet-turbulence interactions are believed to play in combustion instabilities. Despite their importance, droplet-turbulence interactions and their effect on liquid fueled rocket engine performance are not well understood. This is particularly true under supercritical conditions, where many conventional concepts, such as surface tension, no longer apply. Our limited understanding of droplet-turbulence interactions, under both subcritical conditions, represents a major limitation in our ability to design improved liquid previously unavailable information and valuable new insights which will directly impact the design of future liquid fueled rocket engines, as well as, allow for the development of significantly improved spray combustion models, making such models useful design tools.

  16. Hydrolysis of bamboo biomass by subcritical water treatment.

    PubMed

    Mohan, Mood; Banerjee, Tamal; Goud, Vaibhav V

    2015-09-01

    The aim of present study was to obtain total reducing sugars (TRS) from bamboo under subcritical water (SCW) treatment in a batch reactor at the temperature ranging from 170 °C to 220 °C and 40 min hydrolysis time. Experiments were performed to investigate the effects of temperature and time on TRS yield. The maximum TRS yield (42.21%) was obtained at lower temperature (180 °C), however longer reaction time (25 min). X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM) analysis were used to characterise treated and untreated bamboo samples. The XRD profile revealed that crystallinity of bamboo increased to 71.90% with increase in temperature up to 210 °C and decreased thereafter to 70.92%. The first-order reaction kinetic model was used to fit the experimental data to obtain rate constants. From the Arrhenius plot, activation energy and pre-exponential factor at 25 min time were found to be 17.97 kJ mol(-1) and 0.154 min(-1), respectively. PMID:26000834

  17. Evaporation of LOX under supercritical and subcritical conditions

    NASA Technical Reports Server (NTRS)

    Yang, A. S.; Hsieh, W. H.; Kuo, K. K.; Brown, J. J.

    1993-01-01

    The evaporation of LOX under supercritical and subcritical conditions was studied experimentally and theoretically. In experiments, the evaporation rate and surface temperature were measured for LOX strand vaporizing in helium environments at pressures ranging from 5 to 68 atmospheres. Gas sampling and chromatography analysis were also employed to profile the gas composition above the LOX surface for the purpose of model validation. A comprehensive theoretical model was formulated and solved numerically to simulate the evaporation process of LOX at high pressures. The model was based on the conservation equations of mass, momentum, energy, and species concentrations for a multicomponent system, with consideration of gravitational body force, solubility of ambient gases in liquid, and variable thermophysical properties. Good agreement between predictions and measured oxygen mole fraction profiles was obtained. The effect of pressure on the distribution of the Lewis number, as well as the effect of variable diffusion coefficient, were further examined to elucidate the high-pressure transport behavior exhibited in the LOX vaporization process.

  18. Subcritical and supercritical water oxidation of CELSS model wastes

    NASA Astrophysics Data System (ADS)

    Takahashi, Y.; Wydeven, T.; Koo, C.

    Controlled-Ecological-Life-Support-System (CELSS) model wastes were wet-oxidized at temperatures from 250 to 500°C, i.e., below and above the critical point of water (374°C and 218 kg/cm2 or 21.4 MPa). A solution of ammonium hydroxide and acetic acid and a slurry of human urine, feces, and wipes were used as model wastes. Almost all of the organic matter in the model wastes was oxidized in the temperature range from 400 to 500°C, i.e., above the critical conditions for water. In contrast, only a small portion of the organic matter was oxidized at subcritical conditions. Although the extent of nitrogen oxidation to nitrous oxide (N2O) and/or nitrogen gas (N2) increased with reaction temperature, most of the nitrogen was retained in solution as ammonia near 400°C. This important finding suggests that most of the nitrogen in the waste feed can be retained in solution as ammonia during oxidation at low supercritical temperatures and be subsequently used as a nitrogen source for plants in a CELSS while at the same time organic matter is almost completely oxidized to carbon dioxide and water. It was also found in this study the Hastelloy C-276 alloy reactor corroded during waste oxidation. The rate of corrosion was lower above than below the critical temperature for water.

  19. Effect of fluid salinity on subcritical crack propagation in calcite

    NASA Astrophysics Data System (ADS)

    Rostom, Fatma; Røyne, Anja; Dysthe, Dag Kristian; Renard, François

    2013-01-01

    The slow propagation of cracks, also called subcritical crack growth, is a mechanism of fracturing responsible for a ductile deformation of rocks under crustal conditions. In the present study, the double-torsion technique was used to measure the effect of fluid chemistry on the slow propagation of cracks in calcite single crystals at room temperature. Time-lapse images and measurements of force and load-point displacement allowed accurate characterization of crack velocities in a range of 10- 8 to 10- 4 m/s. Velocity curves as a function of energy-release rates were obtained for different fluid compositions, varying NH4Cl and NaCl concentrations. Our results show the presence of a threshold in fluid composition, separating two regimes: weakening conditions where the crack propagation is favored, and strengthening conditions where crack propagation slows down. We suggest that electrostatic surface forces that modify the repulsion forces between the two surfaces of the crack may be responsible for this behavior.

  20. Pati-Salam version of subcritical hybrid inflation

    NASA Astrophysics Data System (ADS)

    Bryant, B. Charles; Raby, Stuart

    2016-05-01

    In this paper we present a model of subcritical hybrid inflation with a Pati-Salam (PS) symmetry group. Both the inflaton and waterfall fields contribute to the necessary e -foldings of inflation, while only the waterfall field spontaneously breaks PS hence monopoles produced during inflation are diluted during the inflationary epoch. The model is able to produce a tensor-to-scalar ratio, r <0.09 consistent with the latest BICEP2/Keck and Planck data, as well as scalar density perturbations and spectral index, ns, consistent with Planck data. For particular values of the parameters, we find r =0.084 and ns=0.0963 . The energy density during inflation is directly related to the PS breaking scale, vPS. The model also incorporates a Z4R symmetry which can resolve the μ problem and suppress dimension 5 operators for proton decay, leaving over an exact R parity. Finally the model allows for a complete three-family extension with a D4 family symmetry which reproduces low energy precision electroweak and LHC data.

  1. Catalytic upgrading of duckweed biocrude in subcritical water.

    PubMed

    Zhang, Caicai; Duan, Peigao; Xu, Yuping; Wang, Bing; Wang, Feng; Zhang, Lei

    2014-08-01

    Herein, a duckweed biocrude produced from the hydrothermal liquefaction of Lemna minor was treated in subcritical water with added H₂. Effects of several different commercially available materials such as Ru/C, Pd/C, Pt/C, Pt/γ-Al₂O₃, Pt/C-sulfide, Rh/γ-Al₂O₃, activated carbon, MoS₂, Mo₂C, Co-Mo/γ-Al₂O₃, and zeolite on the yields of product fractions and the deoxygenation, denitrogenation, and desulfurization of biocrude at 350°C were examined, respectively. All the materials showed catalytic activity for deoxygenation and desulfurization of the biocrude and only Ru/C showed activity for denitrogenation. Of those catalysts examined, Pt/C showed the best performance for deoxygenation. Among all the upgraded oils, the oil produced with Ru/C shows the lowest sulfur, the highest hydrocarbon content (25.6%), the highest energy recovery (85.5%), and the highest higher heating value (42.6 MJ/kg). The gaseous products were mainly unreacted H₂, CH₄, CO₂, and C₂H6. PMID:24880811

  2. The Physics Design for a Fusion Driven Sub-critical System

    NASA Astrophysics Data System (ADS)

    Bin, Wu

    2002-11-01

    The Fusion Driven Sub-critical System (FDS) is a sub-critical nuclear energy system drive by fusion neutron source, which provides a feasible, safe, economic and highly efficient potential of disposing High Level Waste (HLW) and produce fission nuclear fuel as a early application of fusion technology. This paper reviews the past physics reactor design of fusion-fission hybrid reactor in China, and a low aspect ratio tokamak energy system that has been proposed, which aims at high β, good confinement, and steady-state operation in a compact configuration at modest field. The system includes a low aspect ratio tokamak as fusion neutron driver, a radioactivity clean nuclear power system as blanket and novel concept of liquid metal conductor as centre conductor post. Parameters of such kind reactor are the following. Major radius 1.4m, Minor radius 1m, plasma current 9.2MA, Toroidal field 2.5T, Plasma edge q=5, Average density 1.6 10^20m^3, Average temperature 10keV, Plasma volume 50m^3, Bootstrap current fraction 0.72, Fusion power 100MW, Drive power 28MW, Neutron wall loading 1.0MW/m-2. The plasma configuration is an important part in the low-A tokamak. The Eq code has been used to get a equilibrium. From this calculation, we have found a simple set of PF coils that satisfies the requirements of the large elongation plasma configuration and a vertical field with less curve field lines in the low-A tokamak. The natural elongation can be attributed mostly to differences in the current density profile. In order to determine the feasibility of the low-A tokamak operation, a transient simulation has been made which includes the equilibrium, transport and plasma position shape control in the low-A tokamak. A 1-1/2 equilibrium evolution code has been used to make this simulation. The code is two-dimensional time dependent free boundary simulation code that advances the MHD equations describing the transport time-scale evolution of a axisymmetric tokamak plasma.

  3. A Procedure to Predict the Subcritical Turbulent Onset Criterion Applied to a Modified Hasegawa-Wakatani Model

    NASA Astrophysics Data System (ADS)

    Friedman, Brett; Carter, Troy

    2014-10-01

    Linear eigenmode analysis is often used to predict whether a plasma or fluid system will be turbulent, but it fails for systems which have highly non-orthogonal linear eigenvectors. In fact, such systems may become turbulent despite having no unstable linear eigenvectors at all (subcritical turbulence). For about a century, researchers have attempted to predict critical parameters that mark the onset of subcritical turbulence with little success. Using recently-developed intuition regarding the role of non-orthogonal linear eigenvectors in subcritical turbulent sustainment, we have developed a method to calculate turbulent growth rates, which can be used to predict the onset of subcritical turbulence. We apply our procedure to 2D and 3D versions of the Hasegawa-Wakatani (HW) model, showing good agreement with nonlinear simulation results. We also use a modified version of the 3D HW model, which is subject to subcritical turbulence, in order to test our method in predicting the subcritical turbulent onset.

  4. Conceptual design of thorium-fuelled Mitrailleuse accelerator-driven subcritical reactor using D-Be neutron source

    SciTech Connect

    Kokubo, Y.; Kamei, T.

    2012-07-01

    A distributed accelerator is a charged-particle accelerator that uses a new acceleration method based on repeated electrostatic acceleration. This method offers outstanding benefits not possible with the conventional radio-frequency acceleration method, including: (1) high acceleration efficiency, (2) large acceleration current, and (3) lower failure rate made possible by a fully solid-state acceleration field generation circuit. A 'Mitrailleuse Accelerator' is a product we have conceived to optimize this distributed accelerator technology for use with a high-strength neutron source. We have completed the conceptual design of a Mitrailleuse Accelerator and of a thorium-fuelled subcritical reactor driven by a Mitrailleuse Accelerator. This paper presents the conceptual design details and approach to implementing the subcritical reactor core. We will spend the next year or so on detailed design work, and then will start work on developing a prototype for demonstration. If there are no obstacles in setting up a development organization, we expect to finish verifying the prototype's performance by the third quarter of 2015. (authors)

  5. Subcritical bifurcation from planar to cellular interface in Al-0.5 wt% Cu directionally solidified

    SciTech Connect

    Fornaro, O.; Palacio, H.; Biloni, H.

    1998-12-31

    Samples of the Al-0.5 wt% Cu system were directionally grown under controlled conditions, to study the role played by the instabilities in the process relatives to the microstructure selection for a given value of interface velocity, and thermal gradient. Using an interface quenching technique and metallographic analysis in longitudinal and transversal cuts of the samples, the authors determine the transition mechanism between the different stages of the growth, and associate them to the stability of the solidification front. They study the planar to a cellular transition in different conditions, and although the solidification parameters are in good agreement with the perturbation theory, when analyzing the amplitude of the perturbations during the planar to a cellular transition, the same theory is not able to predict certainly the critical wavelength in this case., Also, they found a subcritical behavior during the transition from a planar to a cellular interface for the diluted Al-Cu system, detecting a hysteresis behavior for the amplitude of the perturbations when it is increasing and then decreasing the interface velocity, through the threshold.

  6. Identification of Super- and Subcritical Regions in Shocks Driven by Coronal Mass Ejections

    NASA Astrophysics Data System (ADS)

    Bemporad, A.; Mancuso, S.

    2011-10-01

    In this work, we focus on the analysis of a coronal mass ejection (CME) driven shock observed by the Solar and Heliospheric Observatory/Large Angle and Spectrometric Coronagraph Experiment. We show that white-light coronagraphic images can be employed to estimate the compression ratio X = ρ d /ρ u all along the front of CME-driven shocks. X increases from the shock flanks (where X ~= 1.2) to the shock center (where X ~= 3.0 is maximum). From the estimated X values, we infer the Alfvén Mach number for the general case of an oblique shock. It turns out that only a small region around the shock center is supercritical at earlier times, while higher up in the corona the whole shock becomes subcritical. This suggests that CME-driven shocks could be efficient particle accelerators at the initiation phases of the event, while at later times they progressively loose energy, also losing their capability to accelerate high-energy particles. This result has important implications on the localization of particle acceleration sites and in the context of predictive space weather studies.

  7. Beyond the ponderomotive limit: Direct laser acceleration of relativistic electrons in sub-critical plasmas

    NASA Astrophysics Data System (ADS)

    Arefiev, A. V.; Khudik, V. N.; Robinson, A. P. L.; Shvets, G.; Willingale, L.; Schollmeier, M.

    2016-05-01

    We examine a regime in which a linearly polarized laser pulse with relativistic intensity irradiates a sub-critical plasma for much longer than the characteristic electron response time. A steady-state channel is formed in the plasma in this case with quasi-static transverse and longitudinal electric fields. These relatively weak fields significantly alter the electron dynamics. The longitudinal electric field reduces the longitudinal dephasing between the electron and the wave, leading to an enhancement of the electron energy gain from the pulse. The energy gain in this regime is ultimately limited by the superluminosity of the wave fronts induced by the plasma in the channel. The transverse electric field alters the oscillations of the transverse electron velocity, allowing it to remain anti-parallel to laser electric field and leading to a significant energy gain. The energy enhancement is accompanied by the development of significant oscillations perpendicular to the plane of the driven motion, making trajectories of energetic electrons three-dimensional. Proper electron injection into the laser beam can further boost the electron energy gain.

  8. Target design optimization for an electron accelerator driven subcritical facility with circular and square beam profiles.

    SciTech Connect

    Gohar, M. Y. A; Sofu, T.; Zhong, Z.; Belch, H.; Naberezhnev, D.; Nuclear Engineering Division

    2008-10-30

    A subcritical facility driven by an electron accelerator is planned at the Kharkov Institute of Physics and Technology (KIPT) in Ukraine for medical isotope production, materials research, training, and education. The conceptual design of the facility is being pursued through collaborations between ANL and KIPT. As part of the design effort, the high-fidelity analyses of various target options are performed with formulations to reflect the realistic configuration and the three dimensional geometry of each design. This report summarizes the results of target design optimization studies for electron beams with two different beam profiles. The target design optimization is performed via the sequential neutronic, thermal-hydraulic, and structural analyses for a comprehensive assessment of each configuration. First, a target CAD model is developed with proper emphasis on manufacturability to provide a basis for separate but consistent models for subsequent neutronic, thermal-hydraulic, and structural analyses. The optimizations are pursued for maximizing the neutron yield, streamlining the flow field to avoid hotspots, and minimizing the thermal stresses to increase the durability. In addition to general geometric modifications, the inlet/outlet channel configurations, target plate partitioning schemes, flow manipulations and rates, electron beam diameter/width options, and cladding material choices are included in the design optimizations. The electron beam interactions with the target assembly and the neutronic response of the subcritical facility are evaluated using the MCNPX code. the results for the electron beam energy deposition, neutron generation, and utilization in the subcritical pile are then used to characterize the axisymmetric heat generation profiles in the target assembly with explicit simulations of the beam tube, the coolant, the clad, and the target materials. Both tungsten and uranium are considered as target materials. Neutron spectra from tungsten

  9. Evaporation and combustion of LOX under supercritical and subcritical conditions

    NASA Technical Reports Server (NTRS)

    Yang, A. S.; Hsieh, W. H.; Kuo, K. K.

    1993-01-01

    The objective is to study the evaporation and combustion of LOX under supercritical and subcritical conditions both experimentally and theoretically. In the evaporation studies, evaporation rate and surface temperature were measured when LOX vaporizing in helium environments at pressures ranging from 5 to 68 atm. A Varian 3700 gas chromatograph was employed to measure the oxygen concentration above the LOX surface. For the combustion tests, high-magnification video photography was used to record direct images of the flame shape of a LOX/H2/He laminar diffusion flame. The gas composition in the post-flame region is also being measured with the gas sampling and chromatography analysis. These data are being used to validate the theoretical model. A comprehensive theoretical model with the consideration of the solubility of ambient gases as well as variable thermophysical properties was formulated and solved numerically to study the gasification and burning of LOX at elevated pressures. The calculated flame shape agreed reasonably well with the edge of the observed luminous flame surface. The effect of gravity on the flame structure of laminar diffusion flames was found to be significant. In addition, the predicted results using the flame-sheet model were compared with those based upon full equilibrium calculations (which considered the formation of intermediate species) at supercritical pressures. Except at the flame front where temperature exceeded 2,800 K, the flame-sheet and equilibrium solutions in terms of temperature distributions were in very close agreement. The temperature deviation in the neighborhood of the flame front is caused by the effect of high-temperature dissociation.

  10. Characteristics and Clinical Management of a Cluster of 3 Patients With Ebola Virus Disease, Including the First Domestically Acquired Cases in the United States

    PubMed Central

    Liddell, Allison M.; Davey, Richard T.; Mehta, Aneesh K.; Varkey, Jay B.; Kraft, Colleen S.; Tseggay, Gebre K.; Badidi, Oghenetega; Faust, Andrew C.; Brown, Katia V.; Suffredini, Anthony F.; Barrett, Kevin; Wolcott, Mark J.; Marconi, Vincent C.; Lyon, G. Marshall; Weinstein, Gary L.; Weinmeister, Kenney; Sutton, Shelby; Hazbun, Munir; Albariño, César G.; Reed, Zachary; Cannon, Debi; Ströher, Ute; Feldman, Mark; Ribner, Bruce S.; Lane, H. Clifford; Fauci, Anthony S.; Uyeki, Timothy M.

    2015-01-01

    Background More than 26 000 cases of Ebola virus disease (EVD) have been reported in western Africa, with high mortality. Several patients have been medically evacuated to hospitals in the United States and Europe. Detailed clinical data are limited on the clinical course and management of patients with EVD outside western Africa. Objective To describe the clinical characteristics and management of a cluster of patients with EVD, including the first cases of Ebola virus (EBOV) infection acquired in the United States. Design Retrospective clinical case series. Setting Three U.S. hospitals in September and October 2014. Patients First imported EVD case identified in the United States and 2 secondary EVD cases acquired in the United States in critical care nurses who cared for the index case patient. Measurements Clinical recovery, EBOV RNA level, resolution of Ebola viremia, survival with discharge from hospital, or death. Results The index patient had high EBOV RNA levels, developed respiratory and renal failure requiring critical care support, and died. Both patients with secondary EBOV infection had nonspecific signs and symptoms and developed moderate illness; EBOV RNA levels were moderate, and both patients recovered. Limitation Both surviving patients received uncontrolled treatment with multiple investigational agents, including convalescent plasma, which limits generalizability of the results. Conclusion Early diagnosis, prompt initiation of supportive medical care, and moderate clinical illness likely contributed to successful outcomes in both survivors. The inability to determine the potential benefit of investigational therapies and the effect of patient-specific factors that may have contributed to less severe illness highlight the need for controlled clinical studies of these interventions, especially in the setting of a high level of supportive medical care. Primary Funding Source None. PMID:25961438

  11. Subcritical water extraction of flavoring and phenolic compounds from cinnamon bark (Cinnamomum zeylanicum).

    PubMed

    Khuwijitjaru, Pramote; Sayputikasikorn, Nucha; Samuhasaneetoo, Suched; Penroj, Parinda; Siriwongwilaichat, Prasong; Adachi, Shuji

    2012-01-01

    Cinnamon bark (Cinnamomum zeylanicum) powder was treated with subcritical water at 150 and 200°C in a semi-continuous system at a constant flow rate (3 mL/min) and pressure (6 MPa). Major flavoring compounds, i.e., cinnamaldehyde, cinnamic acid, cinnamyl alcohol and coumarin, were extracted at lower recoveries than the extraction using methanol, suggesting that degradation of these components might occur during the subcritical water treatment. Caffeic, ferulic, p-coumaric, protocatechuic and vanillic acids were identified from the subcritical water treatment. Extraction using subcritical water was more effective to obtain these acids than methanol (50% v/v) in both number of components and recovery, especially at 200°C. Subcritical water treatment at 200°C also resulted in a higher total phenolic content and DPPH radical scavenging activity than the methanol extraction. The DPPH radical scavenging activity and total phenolic content linearly correlated but the results suggested that the extraction at 200°C might result in other products that possessed a free radical scavenging activity other than the phenolic compounds. PMID:22687781

  12. Recurrent intestinal mucinous borderline tumors of the ovary: a report of 5 cases causing problems in diagnosis, including distinction from mucinous carcinoma.

    PubMed

    Irving, Julie A; Clement, Philip B

    2014-03-01

    Intestinal mucinous borderline tumors (IMBTs) of the ovary are generally associated with a highly favorable outcome and rarely recur. We describe 5 cases of IMBT initially treated by cystectomy or by salpingo-oophorectomy that was likely incomplete, with subsequent recurrences. Three cases were received in consultation, and in each of these, the clinical and intraoperative findings were worrisome for mucinous carcinoma, and diagnostic difficulty was encountered by the referring pathologist. The patient age ranged from 28 to 69 (median 53) yrs. All tumors were clinically Stage I at presentation; in at least 3 cases, extensive adhesiolysis was required during their removal. A pathologic diagnosis of IMBT was made in 4 cases; the remaining tumor was inadequately sampled (3 blocks from a 7.5-cm tumor showed predominantly benign to focally borderline mucinous epithelium). A total of 8 recurrences, all as IMBT, developed at mean follow-up of 26 (range, 6-102) mo; 6 of these occurred within ≤2 yr. In 4 cases, removal of recurrent tumor required an extensive operation because of bowel and/or vaginal involvement. Residual ovarian stroma was identified in all recurrences. There was no evidence of invasive mucinous carcinoma, pseudomyxoma peritonei, or a primary tumor elsewhere (including appendix) in any of the cases. Our findings indicate that patients with IMBTs who undergo cystectomy or oophorectomy requiring adhesiolysis are at increased risk of recurrence, which may occur early, be multiple, and potentially require extensive resection if sites such as bowel or vagina are involved. Recurrences of IMBT that develop in this setting likely represent regrowth of incompletely resected IMBT, or arise within residual ovarian tissue. This is the first detailed clinicopathologic study of such cases. PMID:24487471

  13. Subcritical co-solvents extraction of lipid from wet microalgae pastes of Nannochloropsis sp

    PubMed Central

    Chen, Min; Liu, Tianzhong; Chen, Xiaolin; Chen, Lin; Zhang, Wei; Wang, Junfeng; Gao, Lili; Chen, Yu; Peng, Xiaowei

    2012-01-01

    In this paper subcritical co-solvents extraction (SCE) of algal lipid from wet pastes of Nannochloropsis sp. is examined. The influences of five operating parameters including the ratio between ethanol to hexane, the ratio of mixed solvents to algal biomass (dry weight), extraction temperature, pressure, and time were investigated. The determined optimum extraction conditions were 3:1 (hexane to ethanol ratio), 10:1 ratio (co-solvents to microalgae (dry weight) ratio), 90°C, 1.4 MPa, and 50 min, which could produce 88% recovery rate of the total lipids. In addition, electron micrographs of transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were conducted to show that the algal cell presented shrunken, collapsed with some wrinkles and microholes after SCE extraction. The main composition of total lipids extracted under the optimum conditions was TAG which represented more than 80%. And the fatty acid profile of triglycerides revealed that C16:0 (35.67 ± 0.2%), C18:1 (26.84 ± 0.044%) and C16:1 (25.96 ± 0.011%) were dominant. Practical applications: The reported method could save energy consumption significantly through avoiding deep dewatering (for example drying). The composition of the extracted lipid is suitable for the production of high quality biodiesel. PMID:22745570

  14. Green Chromatographic Separation of Coumarin and Vanillins Using Subcritical Water as the Mobile Phase.

    PubMed

    Kayan, Berkant; Akay, Sema; Yang, Yu

    2016-08-01

    Pure water was used as the eluent for separation of coumarin, vanillin and ethyl vanillin at temperatures ranging from 100 to 200°C using a homemade subcritical water chromatography (SBWC) system. Chromatographic separations were performed on five commercial columns including XTerra MS C18, XBridge C18, Zorbax RRHD Eclipse Plus, Zorbax SB-Phenyl and Zorbax SB-C18 columns. The retention time of all three solutes decreased with increasing water temperature. The shortest retention time among all acceptable separations, less than 4 min, was achieved on the Zorbax SB-C18 column at 200°C. While separations on the XTerra MS C18 column resulted in fronting peaks and a degradation peak from ethyl vanillin on the Zorbax RRHD Eclipse Plus column was observed, all three other columns yielded reasonable separations under SBWC conditions. In addition to separation of the standard test mixture, separation of coumarin contained in a skincare cream sample was also carried out using SBWC. PMID:27060112

  15. Energy conversion of biomass with supercritical and subcritical water using large-scale plants.

    PubMed

    Okajima, Idzumi; Sako, Takeshi

    2014-01-01

    Exploiting unused or waste biomass as an alternative fuel is currently receiving much attention because of the potential reductions in CO2 emissions and the lower cost in comparison to expensive fossil fuels. If we are to use biomass domestically or industrially, we must be able to convert biomass to high-quality and easy-to-use liquid, gas, or solid fuels that have high-calorific values, low moisture and ash contents, uniform composition, and suitable for stored over long periods. In biomass treatment, hot and high-pressure water including supercritical and subcritical water is an excellent solvent, as it is clean and safe and its action on biomass can be optimized by varying the temperature and pressure. In this article, the conversion of waste biomass to fuel using hot and high-pressure water is reviewed, and the following examples are presented: the production of large amounts of hydrogen from waste biomass, the production of cheap bioethanol from non-food raw materials, and the production of composite powder fuel from refractory waste biomass in the rubble from the Great East Japan Earthquake. Several promising techniques for the conversion of biomass have been demonstrated in large-scale plants and commercial deployment is expected in the near future. PMID:23867098

  16. Optimization of subcritical water extraction of polysaccharides from Grifola frondosa using response surface methodology

    PubMed Central

    Yang, Liuqing; Qu, Hongyuan; Mao, Guanghua; Zhao, Ting; Li, Fang; Zhu, Bole; Zhang, Bingtao; Wu, Xiangyang

    2013-01-01

    Background: This research is among the few that has been conducted on the feasibility of subcritical water extraction (SWE) as a rapid and efficient extraction tool for polysaccharides. Objective: The aim of the study was to extractand optimize the parameter conditions of SWE of polysaccharides from Grifola frondosa using response surface methodology. Materials and Methods: In the study, SWEwas applied to extractbioactive compounds from G. frondosa. A preliminary analysis was made on the physical properties and content determination of extracts using SWE and hot water extraction (HWE). Analysis of the sample residues and antioxidant activities of the polysaccharides extracted by SWE and HWE were then evaluated. Results: The optimal extraction conditions include: extraction temperature of 210°C, extraction time of 43.65 min and the ratio of water to raw material of 26.15:1. Under these optimal conditions, the experimental yield of the polysaccharides (25.1 ± 0.3%) corresponded with the mean value predicted by the model and two times more than the mean value obtained by the traditional HWE. The antioxidant activities of polysaccharides extracted by SWE were generally higher than those extracted by HWE. From the study, the SWE technology could be a time-saving, high yield, and bioactive technique for production of polysaccharides. PMID:23772107

  17. Complete degradation of Orange G by electrolysis in sub-critical water.

    PubMed

    Yuksel, Asli; Sasaki, Mitsuru; Goto, Motonobu

    2011-06-15

    Complete degradation of azo dye Orange G was studied using a 500 mL continuous flow reactor made of SUS 316 stainless steel. In this system, a titanium reactor wall acted as a cathode and a titanium plate-type electrode was used as an anode in a subcritical reaction medium. This hydrothermal electrolysis process provides an environmentally friendly route that does not use any organic solvents or catalysts to remove organic pollutants from wastewater. Reactions were carried out from 30 to 90 min residence times at a pressure of 7 MPa, and at different temperatures of 180-250°C by applying various direct currents ranging from 0.5 to 1A. Removal of dye from the product solution and conversion of TOC increased with increasing current value. Moreover, the effect of salt addition on degradation of Orange G and TOC conversion was investigated, because in real textile wastewater, many salts are also included together with dye. Addition of Na(2)CO(3) resulted in a massive degradation of the dye itself and complete mineralization of TOC, while NaCl and Na(2)SO(4) obstructed the removal of Orange G. Greater than 99% of Orange G was successfully removed from the product solution with a 98% TOC conversion. PMID:21440367

  18. Subcritical measurements of the WINCO slab tank experiment using the source-jerk technique

    SciTech Connect

    Spriggs, G.D.; Hansen, G.E.; Martin, E.R.; Plassmann, E.A.; Pederson, R.A.; Schlesser, J.A.; Krawczyk, T.L.; Tanner, J.E.; Smolen, G.R.; Martin Marietta Energy Systems, Inc., Oak Ridge, TN; Westinghouse Idaho Nuclear Co., Inc., Idaho Falls, ID; Martin Marietta Energy Systems, Inc., Oak Ridge, TN )

    1989-01-01

    Subcritical measurements of the WINCO slab tank using the source-jerk technique are presented. This technique determines subcriticality by analyzing the transient response produced by the sudden removal of an extraneous neutron source (i.e., a source jerk). We have found that the technique can provide an accurate means of measuring k in configurations that are close to critical (i.e., 0.90 < k < 1.0). As the system becomes more subcritical (i.e., k < 0.90), spatial effects introduce significant biases depending on the source and detector positions. A comparison between the measurements and Monte Carlo code calculations is also presented. 15 refs., 6 figs., 2 tabs.

  19. A Photo-neutron Source for a Sub-Critical Nuclear Reactor Program

    SciTech Connect

    Reda, M.A.; Harmon, J.F.; Sadineni, S.B.

    2003-08-26

    Experiments to benchmark photo-neutron production calculations for an Accelerator Driven Sub-Critical System (ADS) are described. A photo-nuclear based neutron source with output > 1013 n/sec has been proposed as a driver for a program using the sub-critical assembly at Idaho State University. The program is intended to study ADS control issues arising from coupling an accelerator neutron source with a sub-critical assembly. The experiments were performed using the 20 MeV electron linear accelerator at the Idaho Accelerator Center (IAC). Results of calculations, that were made using ACCEPT, PINP, MCNP, and MCNPX codes to optimize photo-nuclear based neutron conversion targets, are compared to experimental data for a single energy measurement.

  20. Incubation time for sub-critical crack propagation in SiC-SiC composites

    SciTech Connect

    El-Azab, A.; Ghoniem, N.M.

    1995-04-01

    The objective of this work is to investigate the time for sub-critical crack propagation is SiC-SiC composites at high temperatures. The effects of fiber thermal creep on the relaxation of crack bridging tractions in SiC-SiC ceramic matrix composites (CMCs) is considered in the present work, with the objective of studying the time-to propagation of sub-critical matrix cracks in this material at high temperatures. Under the condition of fiber stress relaxation in the bridiging zone, it is found that the crack opening and the stress intensity factor increase with time for sub-critical matrix cracks. The time elapsed before the stress intensity reaches the critical value for crack propagation is calculated as a function of the initial crack length, applied stress and temperature. Stability domains for matrix cracks are defined, which provide guidelines for conducting high-temperature crack propagation experiments.

  1. An alternative experimental approach for subcritical configurations of the IPEN/MB-01 nuclear reactor

    NASA Astrophysics Data System (ADS)

    Gonnelli, E.; Lee, S. M.; Pinto, L. N.; Landim, H. R.; Diniz, R.; Jerez, R.; dos Santos, A.

    2015-07-01

    This work presents an alternative approach for the reactivity worth experiments analysis in the IPEN/MB-01 reactor considering highly subcritical arrays. In order to reach the subcritical levels, the removal of a specific number of fuel rods is proposed. Twenty three configurations were carried out for this purpose. The control bank insertion experiment was used only as reference for the fuel rod experiment and, in addition, the control banks were maintained completely withdrawn during all the fuel rods experiment. The theoretical simulation results using the MCNP5 code and the ENDF/B-VII.0 library neutron data are in a very good agreement to experimental results.

  2. Anisotropic etching of monocrystalline silicon under subcritical conditions

    NASA Astrophysics Data System (ADS)

    Gonzalez-Pereyra, Nestor Gabriel

    Sub- and supercritical fluids remain an underexploited resource for materials processing. Around its critical point a common compound such as water behaves like a different substance exhibiting changes in its properties that modify its behavior as a solvent and unlock reaction paths not viable in other conditions. In the subcritical region water's properties can be directed by controlling temperature and pressure. Water and silicon are two of the most abundant, versatile, environmentally non-harmful, and simplest substances on Earth. They are among the most researched and best-known substances. Both are ubiquitous and essential for present-day world. Silicon is fundamental in semiconductor fabrication, microelectromechanical systems, and photovoltaic cells. Wet etching of silicon is a fabrication strategy shared by these three applications. Processing of silicon requires large amounts of water, often involving dangerous and environmentally hazardous chemicals. Yet, minimal knowledge is available on the ways high temperature water interacts with crystalline silicon. The purpose of this project is to identify and implement a method for the modification of monocrystalline silicon surfaces with three important characteristics: 1) requires minimal amounts of added chemicals, 2) controllability of morphological features formed, 3) reduced processing time. This will be accomplished by subjecting crystalline silicon to diluted alkaline solutions working in the subcritical region of water. This approach allows for variations on surface morphologies and etching rates by adapting the reactions conditions, with focus on composition and temperature of the solutions used. The work reported discusses the techniques used for producing surfaces with a variety of morphologies that ultimately allowed to create patterns and textures on silicon wafers, using highly diluted alkaline solutions that can be used for photovoltaic applications. These morphologies were created with a

  3. Recycling high-performance carbon fiber reinforced polymer composites using sub-critical and supercritical water

    NASA Astrophysics Data System (ADS)

    Knight, Chase C.

    Carbon fiber reinforced plastics (CFRP) are composite materials that consist of carbon fibers embedded in a polymer matrix, a combination that yields materials with properties exceeding the individual properties of each component. CFRP have several advantages over metals: they offer superior strength to weight ratios and superior resistance to corrosion and chemical attack. These advantages, along with continuing improvement in manufacturing processes, have resulted in rapid growth in the number of CFRP products and applications especially in the aerospace/aviation, wind energy, automotive, and sporting goods industries. Due to theses well-documented benefits and advancements in manufacturing capabilities, CFRP will continue to replace traditional materials of construction throughout several industries. However, some of the same properties that make CFRP outstanding materials also pose a major problem once these materials reach the end of service life. They become difficult to recycle. With composite consumption in North America growing by almost 5 times the rate of the US GDP in 2012, this lack of recyclability is a growing concern. As consumption increases, more waste will inevitably be generated. Current composite recycling technologies include mechanical recycling, thermal processing, and chemical processing. The major challenge of CFRP recycling is the ability to recover materials of high-value and preserve their properties. To this end, the most suitable technology is chemical processing, where the polymer matrix can be broken down and removed from the fiber, with limited damage to the fibers. This can be achieved using high concentration acids, but such a process is undesirable due to the toxicity of such materials. A viable alternative to acid is water in the sub-critical and supercritical region. Under these conditions, the behavior of this abundant and most environmentally friendly solvent resembles that of an organic compound, facilitating the breakdown

  4. Restoration of Pigmentation by Follicular Unit Extraction Transplant in Three Cases of Focal Vitiligo Recalcitrant to Therapy including with Previous Nonculture Melanocyte-keratinocyte Transplant

    PubMed Central

    Menon, Shruti Mohankumar; Sharma, Yugal K; Bansal, Prakhar; Ghadgepatil, Shruti S

    2016-01-01

    Vitiligo is an acquired, idiopathic depigmentary disease resisting satisfactory repigmentation despite multimodal therapy. Based on the concept of activation of the existing undifferentiated stem cells in the outer root sheet of the hair follicles, follicular unit extraction (FUE) transplant is an interesting advancement in the field of minimally invasive surgery for vitiligo. We herein present three cases of vitiligo whose residual recalcitrant foci as well as poliosis – refractory to therapy including with previous nonculture melanocyte-keratinocyte transplant – repigmented satisfactorily after FUE transplant. PMID:27601864

  5. Restoration of Pigmentation by Follicular Unit Extraction Transplant in Three Cases of Focal Vitiligo Recalcitrant to Therapy including with Previous Nonculture Melanocyte-keratinocyte Transplant.

    PubMed

    Menon, Shruti Mohankumar; Sharma, Yugal K; Bansal, Prakhar; Ghadgepatil, Shruti S

    2016-01-01

    Vitiligo is an acquired, idiopathic depigmentary disease resisting satisfactory repigmentation despite multimodal therapy. Based on the concept of activation of the existing undifferentiated stem cells in the outer root sheet of the hair follicles, follicular unit extraction (FUE) transplant is an interesting advancement in the field of minimally invasive surgery for vitiligo. We herein present three cases of vitiligo whose residual recalcitrant foci as well as poliosis - refractory to therapy including with previous nonculture melanocyte-keratinocyte transplant - repigmented satisfactorily after FUE transplant. PMID:27601864

  6. Extracting organic matter on Mars: A comparison of methods involving subcritical water, surfactant solutions and organic solvents

    NASA Astrophysics Data System (ADS)

    Luong, Duy; Court, Richard W.; Sims, Mark R.; Cullen, David C.; Sephton, Mark A.

    2014-09-01

    The first step in many life detection protocols on Mars involves attempts to extract or isolate organic matter from its mineral matrix. A number of extraction options are available and include heat and solvent assisted methods. Recent operations on Mars indicate that heating samples can cause the loss or obfuscation of organic signals from target materials, raising the importance of solvent-based systems for future missions. Several solvent types are available (e.g. organic solvents, surfactant based solvents and subcritical water extraction) but a comparison of their efficiencies in Mars relevant materials is missing. We have spiked the well characterised Mars analogue material JSC Mars-1 with a number of representative organic standards. Extraction of the spiked JSC Mars-1 with the three solvent methods provides insights into the relative efficiency of these methods and indicates how they may be used on future Mars missions.

  7. The first familial case of inherited 2q37.3 interstitial deletion with isolated skeletal abnormalities including brachydactyly type E and short stature.

    PubMed

    Jean-Marçais, Nolwenn; Decamp, Matthieu; Gérard, Marion; Ribault, Virginie; Andrieux, Joris; Kottler, Marie-Laure; Plessis, Ghislaine

    2015-01-01

    Albright hereditary osteodystrophy (AHO)-like syndrome is also known as brachydactyly-mental retardation syndrome (BDMR; OMIM 60040). This disorder includes intellectual disability in all patients, skeletal abnormalities, including brachydactyly E (BDE) in approximately half, obesity, and facial dysmorphism. Patients with 2q37 microdeletion or HDAC4 mutation are defined as having an AHO-like phenotype with normal stimulatory G (Gs) function. HDAC4 is involved in neurological, cardiac, and skeletal function. This paper reports the first familial case of 2q37.3 interstitial deletion affecting two genes, HDAC4 and TWIST2. Patients presented with BDE and short stature without intellectual disability, showing that haploinsufficiency of the HDAC4 critical region may lead to a spectrum of phenotypes, ranging from isolated brachydactyly type E to BDMR. PMID:25402011

  8. Three case studies of three high school teachers' definitions, beliefs, and implementation practices of inquiry-based science method including barriers to and facilitators of successful implementation

    NASA Astrophysics Data System (ADS)

    Blackburn-Morrison, Kimberly D.

    This study involved three teachers in various stages of implementation of inquiry-based science method. The cases were chosen because one participant was a novice in using inquiry-based science method, one participant was in her second year of implementation, and the third participant was experienced with inquiry-based science method. The cases were set in a rural high school in three different science classrooms. One of the classrooms was a regular biology class. One of the classrooms was an honors oceanography class and another was an advanced placement environmental science classroom. Data sources included interviews, observations, and document collection. Interviews, observations, and document collection were used to triangulate data. Each classroom was observed five times. Interviews were conducted at the beginning of the semester with each participant and at the end of the semester. Follow-up interviews were conducted after each observation. Documents were collected such as each teacher's lesson plans, student work, and assignments. Data was initially organized according to the research areas of teacher's definition, teacher's beliefs, teacher's barriers to implementation, and teacher's enablers to implementation. Then, patterns emerging from each of these cases were organized. Lastly, patterns emerging across cases were compared in a cross-case analysis. Patterns shared between cases were: Participants related inquiry-based science method with hands-on learning activities. Participants saw students as the center of the learning process. Participants had positive beliefs about constructivist learning practices that were strengthened after implementation of inquiry-based teaching. Facilitators of successful implementation of inquiry-based science method were positive student motivation, students' retention of knowledge, and a positive experience for lower level students. Barriers to successful implementation were teachers not having complete control of the

  9. Time-delayed feedback control of coherence resonance near subcritical Hopf bifurcation: Theory versus experiment

    SciTech Connect

    Semenov, Vladimir; Feoktistov, Alexey; Vadivasova, Tatyana; Schöll, Eckehard Zakharova, Anna

    2015-03-15

    Using the model of a generalized Van der Pol oscillator in the regime of subcritical Hopf bifurcation, we investigate the influence of time delay on noise-induced oscillations. It is shown that for appropriate choices of time delay, either suppression or enhancement of coherence resonance can be achieved. Analytical calculations are combined with numerical simulations and experiments on an electronic circuit.

  10. Development of reactivity feedback effect measurement techniques under sub-critical condition in fast reactors

    SciTech Connect

    Kitano, A.; Nishi, H.; Suzuki, T.; Okajima, S.; Kanemoto, S.

    2012-07-01

    The first-of-a-kind reactor has been licensed by a safety examination of the plant design based on the measured data in precedent mock-up experiments. The validity of the safety design can be confirmed without a mock-up experiment, if the reactor feed-back characteristics can be measured before operation, with the constructed reactor itself. The 'Synthesis Method', a systematic and sophisticated method of sub-criticality measurement, is proposed in this work to ensure the safety margin before operation. The 'Synthesis Method' is based on the modified source multiplication method (MSM) combined with the noise analysis method to measure the reference sub-criticality level for MSM. A numerical simulation for the control-rod reactivity worth and the isothermal feed-back reactivity was conducted for typical fast reactors of 100 MWe-size, 300 MWe-size, 750 MWe-size, and 1500 MWe-size to investigate the applicability of Synthesis Method. The number of neutron detectors and their positions necessary for the measurement were investigated for both methods of MSM and the noise analysis by a series of parametric survey calculations. As a result, it was suggested that a neutron detector located above the core center and three or more neutron detectors located above the radial blanket region enable the measurement of sub-criticality within 10% uncertainty from -$0.5 to -$2 and within 15% uncertainty for the deeper sub-criticality. (authors)

  11. ELUTION OF ORGANIC SOLUTES FROM DIFFERENT POLARITY SORBENTS USING SUBCRITICAL WATER. (R825394)

    EPA Science Inventory

    The intermolecular interactions between organic solutes and sorbent matrices under subcritical water conditions have been investigated at a pressure of 50 bar and temperatures ranging from 50 to 250°C. Both polar and nonpolar organics (chlorophenols, amines, n-alkanes...

  12. Time-delayed feedback control of coherence resonance near subcritical Hopf bifurcation: theory versus experiment.

    PubMed

    Semenov, Vladimir; Feoktistov, Alexey; Vadivasova, Tatyana; Schöll, Eckehard; Zakharova, Anna

    2015-03-01

    Using the model of a generalized Van der Pol oscillator in the regime of subcritical Hopf bifurcation, we investigate the influence of time delay on noise-induced oscillations. It is shown that for appropriate choices of time delay, either suppression or enhancement of coherence resonance can be achieved. Analytical calculations are combined with numerical simulations and experiments on an electronic circuit. PMID:25833433

  13. Time-delayed feedback control of coherence resonance near subcritical Hopf bifurcation: Theory versus experiment

    NASA Astrophysics Data System (ADS)

    Semenov, Vladimir; Feoktistov, Alexey; Vadivasova, Tatyana; Schöll, Eckehard; Zakharova, Anna

    2015-03-01

    Using the model of a generalized Van der Pol oscillator in the regime of subcritical Hopf bifurcation, we investigate the influence of time delay on noise-induced oscillations. It is shown that for appropriate choices of time delay, either suppression or enhancement of coherence resonance can be achieved. Analytical calculations are combined with numerical simulations and experiments on an electronic circuit.

  14. Production of keto-disaccharides from aldo-disaccharides in subcritical aqueous ethanol.

    PubMed

    Gao, Da-Ming; Kobayashi, Takashi; Adachi, Shuji

    2016-05-01

    Isomerization of disaccharides (maltose, isomaltose, cellobiose, lactose, melibiose, palatinose, sucrose, and trehalose) was investigated in subcritical aqueous ethanol. A marked increase in the isomerization of aldo-disaccharides to keto-disaccharides was noted and their hydrolytic reactions were suppressed with increasing ethanol concentration. Under any study condition, the maximum yield of keto-disaccharides produced from aldo-disaccharides linked by β-glycosidic bond was higher than that produced from aldo-disaccharides linked by α-glycosidic bond. Palatinose, a keto-disaccharide, mainly underwent decomposition rather than isomerization in subcritical water and subcritical aqueous ethanol. No isomerization was noted for the non-reducing disaccharides trehalose and sucrose. The rate constant of maltose to maltulose isomerization almost doubled by changing solvent from subcritical water to 80 wt% aqueous ethanol at 220 °C. Increased maltose monohydrate concentration in feed decreased the conversion of maltose and the maximum yield of maltulose, but increased the productivity of maltulose. The maximum productivity of maltulose was ca. 41 g/(h kg-solution). PMID:26786171

  15. Reliable-linac design for accelerator-driven subcritical reactor systems.

    SciTech Connect

    Wangler, Thomas P.,

    2002-01-01

    Accelerator reliability corresponding to a very low frequency of beam interrupts is an important new accelerator requirement for accelerator-driven subcritical reactor systems. In this paper we review typical accelerator-reliability requirements and discuss possible methods for meeting these goals with superconducting proton-linac technology.

  16. K/sub infinity/-meter concept verified via subcritical-critical TRIGA experiments

    SciTech Connect

    Ocampo Mansilla, H.

    1983-01-01

    This work presents a technique for building a device to measure the k/sub infinity/ of a spent nuclear fuel assembly discharged from the core of a nuclear power plant. The device, called a k/sub infinity/-meter, consists of a cross-shaped subcritical assembly, two artificial neutron sources, and two separate neutron counting systems. The central position of the subcritical assembly is used to measure k/sub infinity/ of the spent fuel assembly. The initial subcritical assembly is calibrated to determine its k/sub eff/ and verify the assigned k/sub infinity/ of a selected fuel assembly placed in the central position. Count rates are taken with the fuel assembly of known k/sub infinity/'s placed in the central position and then repeated with a fuel assembly of unknown k/sub infinity/ placed in the central position. The count rate ratio of the unknown fuel assembly to the known fuel assembly is used to determine the k/sub infinity/ of the unknown fuel assembly. The k/sub infinity/ of the unknown fuel assembly is represented as a polynomial function of the count rate ratios. The coefficients of the polynomial equation are determined using the neutronic codes LEOPARD and EXTERMINATOR-II. The analytical approach has been validated by performing several subcritical/critical experiments, using the Penn State Breazeale TRIGA Reactor (PSBR), and comparing the experimental results with the calculations.

  17. Compact D-D Neutron Source-Driven Subcritical Multiplier and Beam-Shaping Assembly for Boron Neutron Capture Therapy

    SciTech Connect

    Francesco Ganda; Jasmina Vujic; Ehud Greenspan; Ka-Ngo Leung

    2010-12-01

    This work assesses the feasibility of using a small, safe, and inexpensive keff 0.98 subcritical fission assembly [subcritical neutron multiplier (SCM)] to amplify the treatment neutron beam intensity attainable from a compact deuterium-deuterium (D-D) fusion neutron source delivering [approximately]1012 n/s. The objective is to reduce the treatment time for deep-seated brain tumors to [approximately]1 h. The paper describes the optimal SCM design and two optimal beam-shaping assemblies (BSAs) - one designed to maximize the dose rate and the other designed to maximize the total dose that can be delivered to a deep-seated tumor. The neutron beam intensity amplification achieved with the optimized SCM and BSA results in an increase in the treatment dose rate by a factor of 18: from 0.56 Gy/h without the SCM to 10.1 Gy/h. The entire SCM is encased in an aluminum structure. The total amount of 20% enriched uranium required for the SCM is 8.5 kg, and the cost (not including fabrication) is estimated to be less than $60,000. The SCM power level is estimated at 400 W when driven by a 1012 n/s D-D neutron source. This translates into consumption of only [approximately]0.6% of the initially loaded 235U atoms during 50 years of continuous operation and implies that the SCM could operate continuously for the entire lifetime of the facility without refueling. Cooling the SCM does not pose a challenge; it may be accomplished by natural circulation as the maximum heat flux is only 0.034 W/cm2.

  18. Catalyst-free ethyl biodiesel production from rice bran under subcritical condition

    NASA Astrophysics Data System (ADS)

    Zullaikah, Siti; Afifudin, Riza; Amalia, Rizky

    2015-12-01

    In-situ ethyl biodiesel production from rice bran under subcritical water and ethanol with no catalyst was employed. This process is environmentally friendly and is very flexible in term of feedstock utilization since it can handle relatively high moisture and free fatty acids (FFAs) contents. In addition, the alcohol, i.e. bioethanol, is a non-toxic, biodegradable, and green raw material when produced from non-edible biomass residues, leading to a 100% renewable biodiesel. The fatty acid ethyl esters (FAEEs, ethyl biodiesel) are better than fatty acid methyl esters (FAMEs, methyl biodiesel) in terms of fuel properties, including cetane number, oxidation stability and cold flow properties. The influences of the operating variables such as reaction time (1 - 10 h), ethanol concentration (12.5 - 87.5%), and pressurizing gas (N2 and CO2) on the ethyl biodiesel yield and purity have been investigated systematically while the temperature and pressure were kept constant at 200 °C and 40 bar. The optimum results were obtained at 5 h reaction time and 75% ethanol concentration using CO2 as compressing gas. Ethyl biodiesel yield and purity of 58.78% and 61.35%, respectively, were obtained using rice bran with initial FFAs content of 37.64%. FFAs level was reduced to 14.22% with crude ethyl biodiesel recovery of 95.98%. Increasing the reaction time up to 10 h only increased the yield and purity by only about 3%. Under N2 atmosphere and at the same operating conditions (5h and 75% ethanol), ethyl biodiesel yield and purity decreased to 54.63% and 58.07%, respectively, while FFAs level was increased to 17.93% and crude ethyl biodiesel recovery decreased to 87.32%.

  19. Kinetic and Thermodynamics studies for Castor Oil Extraction Using Subcritical Water Technology.

    PubMed

    Abdelmoez, Wael; Ashour, Eman; Naguib, Shahenaz M; Hilal, Amr; Al Mahdy, Dalia A; Mahrous, Engy A; Abdel-Sattar, Essam

    2016-06-01

    In this work both kinetic and thermodynamics of castor oil extraction from its seeds using subcritical water technique were studied. It was found that the extraction process followed two consecutive steps. In these steps, the oil was firstly extracted from inside the powder by diffusion mechanism. Then the extracted oil, due to extending the extraction time under high temperature and pressure, was subjected to a decomposition reaction following first order mechanism. The experimental data correlated well with the irreversible consecutive unimolecular-type first order mechanism. The values of both oil extraction rate constants and decomposition rate constants were calculated through non-linear fitting using DataFit software. The extraction rate constants were found to be 0.0019, 0.024, 0.098, 0.1 and 0.117 min(-1), while the decomposition rate constants were 0.057, 0.059, 0.014, 0.019 and 0.17 min(-1) at extraction temperatures of 240, 250, 260, 270 and 280°C, respectively. The thermodynamic properties of the oil extraction process were investigated using Arrhenius equation. The values of the activation energy, Ea, and the frequency factor, A, were 73 kJ mol(-1) and 946, 002 min(-1), respectively. The physicochemical properties of the extracted castor oil including the specific gravity, viscosity, acid value, pH value and calorific value were found to be 0.947, 7.487, 1.094 mg KOH/g, 6.1, and 41.5 MJ/Kg, respectively. Gas chromatography analysis showed that ricinoleic acid (83.6%) appears as the predominant fatty acid in the extracted oil followed by oleic acid (5.5%) and linoleic acid (2.3%). PMID:27181250

  20. Recycling high-performance carbon fiber reinforced polymer composites using sub-critical and supercritical water

    NASA Astrophysics Data System (ADS)

    Knight, Chase C.

    Carbon fiber reinforced plastics (CFRP) are composite materials that consist of carbon fibers embedded in a polymer matrix, a combination that yields materials with properties exceeding the individual properties of each component. CFRP have several advantages over metals: they offer superior strength to weight ratios and superior resistance to corrosion and chemical attack. These advantages, along with continuing improvement in manufacturing processes, have resulted in rapid growth in the number of CFRP products and applications especially in the aerospace/aviation, wind energy, automotive, and sporting goods industries. Due to theses well-documented benefits and advancements in manufacturing capabilities, CFRP will continue to replace traditional materials of construction throughout several industries. However, some of the same properties that make CFRP outstanding materials also pose a major problem once these materials reach the end of service life. They become difficult to recycle. With composite consumption in North America growing by almost 5 times the rate of the US GDP in 2012, this lack of recyclability is a growing concern. As consumption increases, more waste will inevitably be generated. Current composite recycling technologies include mechanical recycling, thermal processing, and chemical processing. The major challenge of CFRP recycling is the ability to recover materials of high-value and preserve their properties. To this end, the most suitable technology is chemical processing, where the polymer matrix can be broken down and removed from the fiber, with limited damage to the fibers. This can be achieved using high concentration acids, but such a process is undesirable due to the toxicity of such materials. A viable alternative to acid is water in the sub-critical and supercritical region. Under these conditions, the behavior of this abundant and most environmentally friendly solvent resembles that of an organic compound, facilitating the breakdown

  1. Including screening in van der Waals corrected density functional theory calculations: The case of atoms and small molecules physisorbed on graphene

    SciTech Connect

    Silvestrelli, Pier Luigi; Ambrosetti, Alberto

    2014-03-28

    The Density Functional Theory (DFT)/van der Waals-Quantum Harmonic Oscillator-Wannier function (vdW-QHO-WF) method, recently developed to include the vdW interactions in approximated DFT by combining the quantum harmonic oscillator model with the maximally localized Wannier function technique, is applied to the cases of atoms and small molecules (X=Ar, CO, H{sub 2}, H{sub 2}O) weakly interacting with benzene and with the ideal planar graphene surface. Comparison is also presented with the results obtained by other DFT vdW-corrected schemes, including PBE+D, vdW-DF, vdW-DF2, rVV10, and by the simpler Local Density Approximation (LDA) and semilocal generalized gradient approximation approaches. While for the X-benzene systems all the considered vdW-corrected schemes perform reasonably well, it turns out that an accurate description of the X-graphene interaction requires a proper treatment of many-body contributions and of short-range screening effects, as demonstrated by adopting an improved version of the DFT/vdW-QHO-WF method. We also comment on the widespread attitude of relying on LDA to get a rough description of weakly interacting systems.

  2. Including screening in van der Waals corrected density functional theory calculations: the case of atoms and small molecules physisorbed on graphene.

    PubMed

    Silvestrelli, Pier Luigi; Ambrosetti, Alberto

    2014-03-28

    The Density Functional Theory (DFT)/van der Waals-Quantum Harmonic Oscillator-Wannier function (vdW-QHO-WF) method, recently developed to include the vdW interactions in approximated DFT by combining the quantum harmonic oscillator model with the maximally localized Wannier function technique, is applied to the cases of atoms and small molecules (X=Ar, CO, H2, H2O) weakly interacting with benzene and with the ideal planar graphene surface. Comparison is also presented with the results obtained by other DFT vdW-corrected schemes, including PBE+D, vdW-DF, vdW-DF2, rVV10, and by the simpler Local Density Approximation (LDA) and semilocal generalized gradient approximation approaches. While for the X-benzene systems all the considered vdW-corrected schemes perform reasonably well, it turns out that an accurate description of the X-graphene interaction requires a proper treatment of many-body contributions and of short-range screening effects, as demonstrated by adopting an improved version of the DFT/vdW-QHO-WF method. We also comment on the widespread attitude of relying on LDA to get a rough description of weakly interacting systems. PMID:24697424

  3. Evaluation of the predisposing factors and involved outcome of surgical treatment in bisphosphonate-related osteonecrosis of the jaw cases including bone biopsies

    PubMed Central

    2016-01-01

    Objectives This study examined the statistical relevance of whether the systemic predisposing factors affect the prognosis of surgical treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ). All cases had undergone bone biopsies to determine the characteristics of the mechanisms of BRONJ by optical microscopy. Materials and Methods The data included 54 BRONJ cases who underwent surgery and in whom bone biopsies were performed. The results of surgery were evaluated and the results were classified into 3 categories: normal recovery, delayed recovery, and recurrence after surgery. The medical history, such as diabetes mellitus, medication of steroids, malignancies on other sites was investigated for an evaluation of the systemic predisposing factors in relation to the prognosis. The three factors involved with the medication of bisphosphonate (BP) were the medication route, medication period, and drug holiday of BP before surgery. The serum C-terminal cross-linking telopeptide (CTX) value and presence of microorganism colony in bone biopsy specimens were also checked. Statistical analysis was then carried out to determine the relationship between these factors and the results of surgery. Results The group of patients suffering from diabetes and on steroids tended to show poorer results after surgery. Parenteral medication of BP made the patients have a poorer prognosis after surgery than oral medication. In contrast, the medication period and drug holiday of BP before surgery did not have significance with the results of surgery nor did the serum CTX value and presence of microorganism colony. Necrotic bone specimens in this study typically showed disappearing new bone formation around the osteocytic lacunae and destroyed Howship's lacunae. Conclusion Although many variables exist, this study could in part, predict the prognosis of surgical treatment of BRONJ by taking the patient's medical history. PMID:27595086

  4. Solvent tailoring in coal liquefaction. Quarterly report, May 1982-August 1982. [Comparison of subcritical and supercritical conditions

    SciTech Connect

    Tarrer, A.R.; Guin, J.A.; Curtis, C.W.; Williams, D.C.

    1982-01-01

    The initial objective of this work was to study the phase distribution of donor solvents and solvent mixtures during the liquefaction of coal, to investigate the effects of phase distribution on coal conversion, and to determine the advantages, if any, of operating at subcritical and/or supercritical conditions. Computer simulations were used to predict the phase distribution, for various binary systems, as a function of temperature. The FLASH program was used to theoretically predict phase distribution for various model systems. Due to limitations in the computer program, success was achieved only in a few cases. Even in these cases, the existence of two-phase regions was observed only at temperatures and pressures far below normal liquefaction conditions. An extensive review of the literature was carried out in order to survey methods of experimentally studying vapor-liquid equilibria. Finally, some preliminary laboratory studies were carried out with the use of benzothiophene-dodecane as the model reaction system. It was felt that the study of the effect of reactor configuration on conversion would provide insight into whether phase distribution or mass transfer was the limiting consideration for coal conversion. However, no conclusive results were obtained from these studies.

  5. Exponential speed of uniform convergence of the cell density toward equilibrium for subcritical mass in a Patlak-Keller-Segel model

    NASA Astrophysics Data System (ADS)

    Montaru, Alexandre

    2015-02-01

    This paper is concerned with a chemotaxis aggregation model for cells, more precisely with a parabolic-elliptic semilinear Patlak-Keller-Segel system in a ball of RN, exhibiting a critical mass phenomenon for N ≥ 2. The main result of this paper is the exponential speed of uniform convergence of radial solutions toward the unique steady state in the subcritical case. We stress that this covers in particular the classical Keller-Segel system with N = 2, well known for its critical mass 8π, and that the result improves on the known results even for this most studied problem. A key tool is an associated one-dimensional degenerate parabolic problem. The proof exploits its formal gradient flow structure ut = - ∇F [ u (t) ] on an "infinite dimensional Riemannian manifold". In particular, we show a new Hardy type inequality, equivalent to the strict convexity of F at any steady state of subcritical mass, which heuristically explains the exponential speed of convergence.

  6. Coupling MCNP-DSP and LAHET Monte Carlo Codes for Designing Subcriticality Monitors for Accelerator-Driven Systems

    SciTech Connect

    Valentine, T.E.; Rugama, Y. Munoz-Cobos, J.; Perez, R.

    2000-10-23

    The design of reactivity monitoring systems for accelerator-driven systems must be investigated to ensure that such systems remain subcritical during operation. The Monte Carlo codes LAHET and MCNP-DSP were combined together to facilitate the design of reactivity monitoring systems. The coupling of LAHET and MCNP-DSP provides a tool that can be used to simulate a variety of subcritical measurements such as the pulsed neutron, Rossi-{alpha}, or noise analysis measurements.

  7. The use of linear superconducting electron accelerator for subcritical reactor driving

    NASA Astrophysics Data System (ADS)

    Guk, I. S.; Dovbnya, A. N.; Kononenko, S. G.; Peev, F. A.; Tarasenko, A. S.; van der Wiel, M.; Botman, J. I. M.

    2008-12-01

    At the National Science Centre, Kharkiv Institute of Physics and Technology (NSC KIPT) the possibility of creating an installation with a subcritical reactor driven by an electron accelerator is examined. To obtain the maximal stream of neutrons from a neutron-producing target at a minimal density of energy emission, the electron energy should be in the range of 100-200 MeV and the size of the target should be as large as possible. Other important requirements are beam continuity with time and long-term stability of the accelerator parameters. The variants of using the superconducting linear accelerator on the basis of a TESLA accelerating structure as of subcritical reactor driver are considered. The basic design parameters and characteristics of this installation are presented.

  8. Temperature Profile of the Solution Vessel of an Accelerator-Driven Subcritical Fissile Solution System

    SciTech Connect

    Klein, Steven Karl; Determan, John C.

    2015-09-14

    Dynamic System Simulation (DSS) models of fissile solution systems have been developed and verified against a variety of historical configurations. DSS techniques have been applied specifically to subcritical accelerator-driven systems using fissile solution fuels of uranium. Initial DSS models were developed in DESIRE, a specialized simulation scripting language. In order to tailor the DSS models to specifically meet needs of system designers they were converted to a Visual Studio implementation, and one of these subsequently to National Instrument’s LabVIEW for human factors engineering and operator training. Specific operational characteristics of subcritical accelerator-driven systems have been examined using a DSS model tailored to this particular class using fissile fuel.

  9. Research program for the 660 MeV proton accelerator driven MOX-plutonium subcritical assembly

    NASA Astrophysics Data System (ADS)

    Barashenkov, V. S.; Buttsev, V. S.; Buttseva, G. L.; Dudarev, S. Ju.; Polanski, A.; Puzynin, I. V.; Sissakian, A. N.

    2000-07-01

    This paper presents the research program of the Experimental Accelerator Driven System (ADS), which employs a subcritical assembly and a 660 MeV proton accelerator operating in the Laboratory of Nuclear Problems at the Joint Institute for Nuclear Research in Dubna. Mixed-oxide (MOX) fuel (25% PuO2+75% UO2) designed for the BN-600 reactor use will be adopted for the core of the assembly. The present conceptual design of the experimental subcritical assembly is based on a core nominal unit capacity of 15 kW (thermal). This corresponds to the multiplication coefficient keff=0.945, energetic gain G=30, and accelerator beam power of 0.5 kW.

  10. A fusion-driven subcritical system concept based on viable technologies

    NASA Astrophysics Data System (ADS)

    Wu, Y.; Jiang, J.; Wang, M.; Jin, M.; FDS Team

    2011-10-01

    A fusion-driven hybrid subcritical system (FDS) concept has been designed and proposed as spent fuel burner based on viable technologies. The plasma fusion driver can be designed based on relatively easily achieved plasma parameters extrapolated from the successful operation of existing fusion experimental devices such as the EAST tokamak in China and other tokamaks in the world, and the subcritical fission blanket can be designed based on the well-developed technologies of fission power plants. The simulation calculations and performance analyses of plasma physics, neutronics, thermal-hydraulics, thermomechanics and safety have shown that the proposed concept can meet the requirements of tritium self-sufficiency and sufficient energy gain as well as effective burning of nuclear waste from fission power plants and efficient breeding of nuclear fuel to feed fission power plants.

  11. Degradation of caffeic acid in subcritical water and online HPLC-DPPH assay of degradation products.

    PubMed

    Khuwijitjaru, Pramote; Suaylam, Boonyanuch; Adachi, Shuji

    2014-02-26

    Caffeic acid was subjected to degradation under subcritical water conditions within 160-240 °C and at a constant pressure of 5 MPa in a continuous tubular reactor. Caffeic acid degraded quickly at these temperatures; the main products identified by liquid chromatography-diode array detection/mass spectrometry were hydroxytyrosol, protocatechuic aldehyde, and 4-vinylcatechol. The reaction rates for the degradation of caffeic acid and the formation of products were evaluated. Online high-performance liquid chromatography/2,2-diphenyl-1-picryhydrazyl assay was used to determine the antioxidant activity of each product in the solution. It was found that the overall antioxidant activity of the treated solution did not change during the degradation process. This study showed a potential of formation of antioxidants from natural phenolic compounds under these subcritical water conditions, and this may lead to a discovering of novel antioxidants compounds during the extraction by this technique. PMID:24483598

  12. Accelerator driven system based on plutonium subcritical reactor and 660 MeV phasotron

    SciTech Connect

    Arkhipov, V. A.; Barashenkov, V. S.; Buttsev, V. S.; Chultem, D.; Furman, V. I.; Maltsev, A. A.; Onischenko, L. M.; Pogodajev, G. N.; Popov, Yu. P.; Puzynin, I. V.; Sissakian, A. N.; Dudarev, S. Yu.; Gudowski, W.; Janczyszyn, J.; Polanski, A.; Taczanowski, S.

    1999-11-16

    The proposal presents a PLUTONIUM BASED ENERGY AMPLIFIER TESTING CONCEPT which employs a plutonium subcritical assembly and a 660 MeV proton accelerator, operating in the the JINR (Dubna, Russia). To make the present conceptual design of the Plutonium Energy Amplifier we have chosen a nominal unit capacity of 20 kW (thermal). This corresponds to the multiplication coefficient keff between 0.94 and 0.95 and the energetic gain about 20.

  13. Accelerator Driven System Based on Plutonium Subcritical Reactor and 660 MeV Phasotron

    SciTech Connect

    Arkhipov, V.A.; Barashenkov, V.S.; Buttsev, V.S.; Chultem, D.; Dudarev, S.Yu.; Furman, V.I.; Gudowski, W.; Janczyszyn, J.; Maltsev, A.A.; Onischenko, L.M.; Pogodajev, G.N.; Polanski, A.; Popov, Yu.P.; Puzynin, I.V.; Sissakian, A.N.; Taczanowski, S.

    1999-12-31

    The proposal presents a PLUTONIUM BASED ENERGY AMPLIFIER TESTING CONCEPT which employs a plutonium subcritical assembly and a 660 MeV proton accelerator. operating in the JINR (Dubna, Russia). To make the present conceptual design of the Plutonium Energy Amplifier we have chosen a nominal unit capacity of 20 kW (thermal). This corresponds to a multiplication coefficient, keff, between 0.94 and 0.95 and an energy gain about 20.

  14. Extraction of polychlorinated biphenyl with supercritical carbon dioxide, sulfur hexafluoride and subcritical water.

    PubMed

    Pross, S; Gau, W; Wenclawiak, B W

    2000-05-01

    In the extraction of spiked PCB from soil, three extracting fluids were investigated: supercritical carbon dioxide (CO2), supercritical sulfur hexafluoride (SF6) and subcritical water. Among the tested fluids SF6 appeared to be appropriate especially for the extraction of low polar PCB. CO2 and water were found to be suitable for the quantitative extraction of all PCB. Water was judged as the best because of its low price, good availability and environmental safety. PMID:11227442

  15. YALINA-booster subcritical assembly pulsed-neutron experiments : data processing and spatial corrections.

    SciTech Connect

    Cao, Y.; Gohar, Y.; Nuclear Engineering Division

    2010-10-11

    The YALINA-Booster experiments and analyses are part of the collaboration between Argonne National Laboratory of USA and the Joint Institute for Power & Nuclear Research - SOSNY of Belarus for studying the physics of accelerator driven systems for nuclear energy applications using low enriched uranium. The YALINA-Booster subcritical assembly is utilized for studying the kinetics of accelerator driven systems with its highly intensive D-T or D-D pulsed neutron source. In particular, the pulsed neutron methods are used to determine the reactivity of the subcritical system. This report examines the pulsed-neutron experiments performed in the YALINA-Booster facility with different configurations for the subcritical assembly. The 1141 configuration with 90% U-235 fuel and the 1185 configuration with 36% or 21% U-235 fuel are examined. The Sjoestrand area-ratio method is utilized to determine the reactivities of the different configurations. The linear regression method is applied to obtain the prompt neutron decay constants from the pulsed-neutron experimental data. The reactivity values obtained from the experimental data are shown to be dependent on the detector locations inside the subcritical assembly and the types of detector used for the measurements. In this report, Bell's spatial correction factors are calculated based on a Monte Carlo model to remove the detector dependences. The large differences between the reactivity values given by the detectors in the fast neutron zone of the YALINA-Booster are reduced after applying the spatial corrections. In addition, the estimated reactivity values after the spatial corrections are much less spatially dependent.

  16. The effect of fluid composition, salinity, and acidity on subcritical crack growth in calcite crystals

    NASA Astrophysics Data System (ADS)

    Bergsaker, Anne Schad; Røyne, Anja; Ougier-Simonin, Audrey; Aubry, Jérôme; Renard, François

    2016-03-01

    Chemically activated processes of subcritical cracking in calcite control the time-dependent strength of this mineral, which is a major constituent of the Earth's brittle upper crust. Here experimental data on subcritical crack growth are acquired with a double torsion apparatus to characterize the influence of fluid pH (range 5-7.5) and ionic strength and species (Na2SO4, NaCl, MgSO4, and MgCl2) on the propagation of microcracks in calcite single crystals. The effect of different ions on crack healing has also been investigated by decreasing the load on the crack for durations up to 30 min and allowing it to relax and close. All solutions were saturated with CaCO3. The crack velocities reached during the experiments are in the range 10-9-10-2 m/s and cover the range of subcritical to close to dynamic rupture propagation velocities. Results show that for calcite saturated solutions, the energy necessary to fracture calcite is independent of pH. As a consequence, the effects of fluid salinity, measured through its ionic strength, or the variation of water activity have stronger effects on subcritical crack propagation in calcite than pH. Consequently, when considering the geological sequestration of CO2 into carbonate reservoirs, the decrease of pH within the range of 5-7.5 due to CO2 dissolution into water should not significantly alter the rate of fracturing of calcite. Increase in salinity caused by drying may lead to further reduction in cracking and consequently a decrease in brittle creep. The healing of cracks is found to vary with the specific ions present.

  17. Turbulence effect on crossflow around a circular cylinder at subcritical Reynolds numbers

    NASA Technical Reports Server (NTRS)

    Sadeh, W. Z.; Saharon, D. B.

    1982-01-01

    An investigation of the effect of freestream turbulence on the flow around a smooth circular cylinder at subcritical Reynolds numbers from 5.2 x 10 to the 4th power to 2.09 x 10 to the 5th power was conducted. Measurements show that the interaction of incident turbulence with the initial laminar boundary layer: (1) modifies the characteristics of the mean surface pressure distribution; (2) induces an aft shift in the separation point ranging from 5 to 50 beyond the laminar separation angle of 80 degrees; and, (3) reduces the mean drag coefficient to values between 97 and 46% of its nearly constant laminar counterpart. The extent of these changes depends on the particular Reynolds number background turbulence combination. These results demonstrate that a boundary-layer flow similar to that found in critical, supercritical and/or transcritical flow regimes is induced by turbulence at subcritical Reynolds numbers and, hence, the effect of turbulence is equivalent to an effective increase in the Reynolds number. The change in the nature and properties of the boundary layer in the subcritical regime, consequent upon the penetration of turbulence into it, is in agreement with the model proposed by the vorticity-amplification theory.

  18. Vortex-induced vibrations of pipes conveying fluid in the subcritical and supercritical regimes

    NASA Astrophysics Data System (ADS)

    Dai, H. L.; Wang, L.; Qian, Q.; Ni, Q.

    2013-05-01

    In this paper, the vortex-induced vibrations of a hinged-hinged pipe conveying fluid are examined, by considering the internal fluid velocities ranging from the subcritical to the supercritical regions. The nonlinear coupled equations of motion are discretized by employing a four-mode Galerkin method. Based on numerical simulations, diagrams of the displacement amplitude versus the external fluid reduced velocity are constructed for pipes transporting subcritical and supercritical fluid flows. It is shown that when the internal fluid velocity is in the subcritical region, the pipe is always vibrating periodically around the pre-buckling configuration and that with increasing external fluid reduced velocity the peak amplitude of the pipe increases first and then decreases, with jumping phenomenon between the upper and lower response branches. When the internal fluid velocity is in the supercritical region, however, the pipe displays various dynamical behaviors around the post-buckling configuration such as inverse period-doubling bifurcations, periodic and chaotic motions. Moreover, the bifurcation diagrams for vibration amplitude of the pipe with varying internal fluid velocities are constructed for each of the lowest four modes of the pipe in the lock-in conditions. The results show that there is a significant difference between the vibrations of the pipe around the pre-buckling configuration and those around the post-buckling configuration.

  19. Th and U fuel photofission study by NTD for AD-MSR subcritical assembly

    NASA Astrophysics Data System (ADS)

    Sajo-Bohus, Laszlo; Greaves, Eduardo D.; Davila, Jesus; Barros, Haydn; Pino, Felix; Barrera, Maria T.; Farina, Fulvio

    2015-07-01

    During the last decade a considerable effort has been devoted for developing energy generating systems based on advanced nuclear technology within the design concepts of GEN-IV. Thorium base fuel systems such as accelerator driven nuclear reactors are one of the often mentioned attractive and affordable options. Several radiotherapy linear accelerators are on the market and due to their reliability, they could be employed as drivers for subcritical liquid fuel assemblies. Bremsstrahlung photons with energies above 5.5MeV, induce (γ,n) and (e,e'n) reactions in the W-target. Resulting gamma radiation and photo or fission neutrons may be absorbed in target materials such as thorium and uranium isotopes to induce sustained fission or nuclear transmutation in waste radioactive materials. Relevant photo driven and photo-fission reaction cross sections are important for actinides 232Th, 238U and 237Np in the radiotherapy machines energy range of 10-20 MV. In this study we employ passive nuclear track detectors (NTD) to determine fission rates and neutron production rates with the aim to establish the feasibility for gamma and photo-neutron driven subcritical assemblies. To cope with these objectives a 20 MV radiotherapy machine has been employed with a mixed fuel target. Results will support further development for a subcritical assembly employing a thorium containing liquid fuel. It is expected that acquired technological knowledge will contribute to the Venezuelan nuclear energy program.

  20. Dead-Time Effects on Counting Statistics in Subcritical Nuclear Systems

    SciTech Connect

    Difilippo, Felix C.

    2002-10-15

    The analysis of the fluctuations of signals coming from detectors in the vicinity of a subcritical assembly of fissile materials is commonly used for the control and safeguard of nuclear materials and might be used for the surveillance of an accelerator driven system. One of the stochastic techniques is the measurement of the probability distributions of counts in time intervals {delta}t (gates); the departure of the ratio of the variance and the mean value with respect to 1 (the correlation) is directly related to the amount of fissile material and its subcriticality. The measurement of this correlation is affected by dead-time effects due to count losses because of the finite-time resolution of the detection system. We present a theory that allows (a) the calculation of the probability of losing n counts (P{sup (n)}) in gate {delta}t, (b) the definition of experimental conditions under which P{sup (2)} << P{sup (1)}, and (c) a methodology to correct the measured correlation because of losing one count in any gate. The theory is applied to the analysis of experiments performed in a highly enriched subcritical assembly.

  1. Feasibility study of noise analysis methods on virtual thermal reactor subcriticality monitoring

    SciTech Connect

    Kong, C.; Lee, D.; Lee, E.

    2013-07-01

    This paper presents the analysis results of Rossi-alpha, cross-correlation, Feynman-alpha, and Feynman difference methods applied to the subcriticality monitoring of nuclear reactors. A thermal spectrum Godiva model has been designed for the analysis of the four methods. This Godiva geometry consists of a spherical core containing the isotopes of H-l, U-235 and U-238, and the H{sub 2}O reflector outside the core. A Monte Carlo code, McCARD, is used in real time mode to generate virtual detector signals to analyze the feasibility of the four methods. The analysis results indicate that the four methods can be used with high accuracy for the continuous monitoring of subcriticality. In addition to that, in order to analyze the impact of the random noise contamination on the accuracy of the noise analysis, the McCARD-generated signals are contaminated with arbitrary noise. It is noticed that, even when the detector signals are contaminated, the four methods can predict the subcriticality with reasonable accuracy. Nonetheless, in order to reduce the adverse impact of the random noise, eight detector signals, rather than a single signal, are generated from the core, one signal from each equally divided eighth part of the core. The preliminary analysis with multiple virtual detector signals indicates that the approach of using many detectors is promising to improve the accuracy of criticality prediction and further study will be performed in this regard. (authors)

  2. Advanced Subcritical Assistance Radioisotope Thermoelectric Generator: An Imperative Solution for the Future of NASA Exploration

    NASA Astrophysics Data System (ADS)

    Arias, F. J.

    A new generation of radioisotope thermoelectrical generator is proposed for very long space exploration missions. The Advanced Subcritical Assistance Radioisotope Thermoelectric Generator (ASA-RTG) amplify the power from natural decay of pu-238 by a small subcritical multiplication produced from the small neutron background generated from (α, n) reactions between the α particles from Pu-238 and beryllium, lithium or other low-Z isotope, extracting the maximum advantage and performance from the precious α disintegration, and then of the very scarce pu-238. The process is self controlled by the natural decay of Pu-238 with the progressive reduction of the power output (RTG) and additionally and simultaneously compensate by the natural decay of a neutronic poisson which increase simultaneously the subcritical multiplication resulting in a contrary effect, i.e., causing an increase in the power. ASA-RTG is not in conflict with previous RTG, and could fit within the type of Radioisotope Thermoelectric Generator developed for NASA space missions as the Multi-Mission Radioisotope Thermoelectric Generator (MMRTG) and the Advanced Stirling Radioisotope Generator (ASRG).

  3. Measurements of the subcriticality using advanced technique of shooting source during operation of NPP reactors

    NASA Astrophysics Data System (ADS)

    Lebedev, G. V.; Petrov, V. V.; Bobylyov, V. T.; Butov, R. I.; Zhukov, A. M.; Sladkov, A. A.

    2014-12-01

    According to the rules of nuclear safety, the measurements of the subcriticality of reactors should be carried out in the process of performing nuclear hazardous operations. An advanced technique of shooting source of neutrons is proposed to meet this requirement. As such a source, a pulsed neutron source (PNS) is used. In order to realize this technique, it is recommended to enable a PNS with a frequency of 1-20 Hz. The PNS is stopped after achieving a steady-state (on average) number of neutrons in the reactor volume. The change in the number of neutrons in the reactor volume is measured in time with an interval of discreteness of ˜0.1 s. The results of these measurements with the application of a system of point-kinetics equations are used in order to calculate the sought subcriticality. The basic idea of the proposed technique used to measure the subcriticality is elaborated in a series of experiments on the Kvant assembly. The conditions which should be implemented in order to obtain a positive result of measurements are formulated. A block diagram of the basic version of the experimental setup is presented, whose main element is a pulsed neutron generator.

  4. Measurements of the subcriticality using advanced technique of shooting source during operation of NPP reactors

    SciTech Connect

    Lebedev, G. V. Petrov, V. V.; Bobylyov, V. T.; Butov, R. I.; Zhukov, A. M.; Sladkov, A. A.

    2014-12-15

    According to the rules of nuclear safety, the measurements of the subcriticality of reactors should be carried out in the process of performing nuclear hazardous operations. An advanced technique of shooting source of neutrons is proposed to meet this requirement. As such a source, a pulsed neutron source (PNS) is used. In order to realize this technique, it is recommended to enable a PNS with a frequency of 1–20 Hz. The PNS is stopped after achieving a steady-state (on average) number of neutrons in the reactor volume. The change in the number of neutrons in the reactor volume is measured in time with an interval of discreteness of ∼0.1 s. The results of these measurements with the application of a system of point-kinetics equations are used in order to calculate the sought subcriticality. The basic idea of the proposed technique used to measure the subcriticality is elaborated in a series of experiments on the Kvant assembly. The conditions which should be implemented in order to obtain a positive result of measurements are formulated. A block diagram of the basic version of the experimental setup is presented, whose main element is a pulsed neutron generator.

  5. Subcritical crack growth in soda-lime glass in combined mode I and mode II loading

    NASA Technical Reports Server (NTRS)

    Singh, Dileep; Shetty, Dinesh K.

    1990-01-01

    Subcritical crack growth under mixed-mode loading was studied in soda-lime glass. Pure mode I, combined mode I and mode II, and pure mode II loadings were achieved in precracked disk specimens by loading in diametral compression at selected angles with respect to the symmetric radial crack. Crack growth was monitored by measuring the resistance changes in a microcircuit grid consisting of parallel, electrically conducting grid lines deposited on the surface of the disk specimens by photolithography. Subcritical crack growth rates in pure mode I, pure mode II, and combined mode I and mode II loading could be described by an exponential relationship between crack growth rate and an effective crack driving force derived from a mode I-mode II fracture toughness envelope. The effective crack driving force was based on an empirical representation of the noncoplanar strain energy release rate. Stress intensities for kinked cracks were assessed using the method of caustics and an initial decrease and a subsequent increase in the subcritical crack growth rates of kinked cracks were shown to correlate with the variations of the mode I and the mode II stress intensities.

  6. Concept of an accelerator-driven subcritical research reactor within the TESLA accelerator installation

    NASA Astrophysics Data System (ADS)

    Pešić, Milan; Nešković, Nebojša

    2006-06-01

    Study of a small accelerator-driven subcritical research reactor in the Vinča Institute of Nuclear Sciences was initiated in 1999. The idea was to extract a beam of medium-energy protons or deuterons from the TESLA accelerator installation, and to transport and inject it into the reactor. The reactor core was to be composed of the highly enriched uranium fuel elements. The reactor was designated as ADSRR-H. Since the use of this type of fuel elements was not recommended any more, the study of a small accelerator-driven subcritical research reactor employing the low-enriched uranium fuel elements began in 2004. The reactor was designated as ADSRR-L. We compare here the results of the initial computer simulations of ADSRR-H and ADSRR-L. The results have confirmed that our concept could be the basis for designing and construction of a low neutron flux model of the proposed accelerator-driven subcritical power reactor to be moderated and cooled by lead. Our objective is to study the physics and technologies necessary to design and construct ADSRR-L. The reactor would be used for development of nuclear techniques and technologies, and for basic and applied research in neutron physics, metrology, radiation protection and radiobiology.

  7. Th and U fuel photofission study by NTD for AD-MSR subcritical assembly

    SciTech Connect

    Sajo-Bohus, Laszlo; Greaves, Eduardo D.; Barros, Haydn; Pino, Felix; Barrera, Maria T.; Farina, Fulvio; Davila, Jesus

    2015-07-23

    During the last decade a considerable effort has been devoted for developing energy generating systems based on advanced nuclear technology within the design concepts of GEN-IV. Thorium base fuel systems such as accelerator driven nuclear reactors are one of the often mentioned attractive and affordable options. Several radiotherapy linear accelerators are on the market and due to their reliability, they could be employed as drivers for subcritical liquid fuel assemblies. Bremsstrahlung photons with energies above 5.5MeV, induce (γ,n) and (e,e’n) reactions in the W-target. Resulting gamma radiation and photo or fission neutrons may be absorbed in target materials such as thorium and uranium isotopes to induce sustained fission or nuclear transmutation in waste radioactive materials. Relevant photo driven and photo-fission reaction cross sections are important for actinides {sup 232}Th, {sup 238}U and {sup 237}Np in the radiotherapy machines energy range of 10-20 MV. In this study we employ passive nuclear track detectors (NTD) to determine fission rates and neutron production rates with the aim to establish the feasibility for gamma and photo-neutron driven subcritical assemblies. To cope with these objectives a 20 MV radiotherapy machine has been employed with a mixed fuel target. Results will support further development for a subcritical assembly employing a thorium containing liquid fuel. It is expected that acquired technological knowledge will contribute to the Venezuelan nuclear energy program.

  8. Effects of Including Misidentified Sharks in Life History Analyses: A Case Study on the Grey Reef Shark Carcharhinus amblyrhynchos from Papua New Guinea.

    PubMed

    Smart, Jonathan J; Chin, Andrew; Baje, Leontine; Green, Madeline E; Appleyard, Sharon A; Tobin, Andrew J; Simpfendorfer, Colin A; White, William T

    2016-01-01

    Fisheries observer programs are used around the world to collect crucial information and samples that inform fisheries management. However, observer error may misidentify similar-looking shark species. This raises questions about the level of error that species misidentifications could introduce to estimates of species' life history parameters. This study addressed these questions using the Grey Reef Shark Carcharhinus amblyrhynchos as a case study. Observer misidentification rates were quantified by validating species identifications using diagnostic photographs taken on board supplemented with DNA barcoding. Length-at-age and maturity ogive analyses were then estimated and compared with and without the misidentified individuals. Vertebrae were retained from a total of 155 sharks identified by observers as C. amblyrhynchos. However, 22 (14%) of these were sharks were misidentified by the observers and were subsequently re-identified based on photographs and/or DNA barcoding. Of the 22 individuals misidentified as C. amblyrhynchos, 16 (73%) were detected using photographs and a further 6 via genetic validation. If misidentified individuals had been included, substantial error would have been introduced to both the length-at-age and the maturity estimates. Thus validating the species identification, increased the accuracy of estimated life history parameters for C. amblyrhynchos. From the corrected sample a multi-model inference approach was used to estimate growth for C. amblyrhynchos using three candidate models. The model averaged length-at-age parameters for C. amblyrhynchos with the sexes combined were L∞ = 159 cm TL and L0 = 72 cm TL. Females mature at a greater length (l50 = 136 cm TL) and older age (A50 = 9.1 years) than males (l50 = 123 cm TL; A50 = 5.9 years). The inclusion of techniques to reduce misidentification in observer programs will improve the results of life history studies and ultimately improve management through the use of more accurate data

  9. Effects of Including Misidentified Sharks in Life History Analyses: A Case Study on the Grey Reef Shark Carcharhinus amblyrhynchos from Papua New Guinea

    PubMed Central

    Smart, Jonathan J.; Chin, Andrew; Baje, Leontine; Green, Madeline E.; Appleyard, Sharon A.; Tobin, Andrew J.; Simpfendorfer, Colin A.; White, William T.

    2016-01-01

    Fisheries observer programs are used around the world to collect crucial information and samples that inform fisheries management. However, observer error may misidentify similar-looking shark species. This raises questions about the level of error that species misidentifications could introduce to estimates of species’ life history parameters. This study addressed these questions using the Grey Reef Shark Carcharhinus amblyrhynchos as a case study. Observer misidentification rates were quantified by validating species identifications using diagnostic photographs taken on board supplemented with DNA barcoding. Length-at-age and maturity ogive analyses were then estimated and compared with and without the misidentified individuals. Vertebrae were retained from a total of 155 sharks identified by observers as C. amblyrhynchos. However, 22 (14%) of these were sharks were misidentified by the observers and were subsequently re-identified based on photographs and/or DNA barcoding. Of the 22 individuals misidentified as C. amblyrhynchos, 16 (73%) were detected using photographs and a further 6 via genetic validation. If misidentified individuals had been included, substantial error would have been introduced to both the length-at-age and the maturity estimates. Thus validating the species identification, increased the accuracy of estimated life history parameters for C. amblyrhynchos. From the corrected sample a multi-model inference approach was used to estimate growth for C. amblyrhynchos using three candidate models. The model averaged length-at-age parameters for C. amblyrhynchos with the sexes combined were  L¯∞ = 159 cm TL and  L¯0 = 72 cm TL. Females mature at a greater length (l50 = 136 cm TL) and older age (A50 = 9.1 years) than males (l50 = 123 cm TL; A50 = 5.9 years). The inclusion of techniques to reduce misidentification in observer programs will improve the results of life history studies and ultimately improve management through the use of more

  10. Subcritical and supercritical water oxidation of organic, wet wastes for carbon cycling in regenerative life support systems

    NASA Astrophysics Data System (ADS)

    Ronsse, Frederik; Lasseur, Christophe; Rebeyre, Pierre; Clauwaert, Peter; Luther, Amanda; Rabaey, Korneel; Zhang, Dong Dong; López Barreiro, Diego; Prins, Wolter; Brilman, Wim

    2016-07-01

    For long-term human spaceflight missions, one of the major requirements is the regenerative life support system which has to be capable of recycling carbon, nutrients and water from both solid and liquid wastes generated by the crew and by the local production of food through living organisms (higher plants, fungi, algae, bacteria, …). The European Space Agency's Life Support System, envisioned by the MELiSSA project, consists of a 5 compartment artificial ecosystem, in which the waste receiving compartment (so-called compartment I or briefly 'CI') is based on thermophilic fermentation. However, as the waste generated by the crew compartment and food production compartment contain typical plant fibres (lignin, cellulose and hemicellulose), these recalcitrant fibres end up largely unaffected in the digestate (sludge) generated in the C-I compartment. Therefore, the C-I compartment has to be supplemented with a so-called fibre degradation unit (in short, FDU) for further oxidation or degradation of said plant fibres. A potential solution to degrading these plant fibres and other recalcitrant organics is their oxidation, by means of subcritical or supercritical water, into reusable CO2 while retaining the nutrients in an organic-free liquid effluent. By taking advantage of the altered physicochemical properties of water above or near its critical point (647 K, 22.1 MPa) - including increased solubility of non-polar compounds and oxygen, ion product and diffusivity - process conditions can be created for rapid oxidation of C into CO2. In this research, the oxidizer is provided as a hydrogen peroxide solution which, at elevated temperature, will dissociated into O2. The purpose of this study is to identify ideal process conditions which (a) ensure complete oxidation of carbon, (b) retaining the nutrients other than C in the liquid effluent and (c) require as little oxidizer as possible. Experiments were conducted on a continuous, tubular heated reactor and on batch