Sample records for inconsistent research findings

  1. The Impact of Extent of Telecommuting on Job Satisfaction: Resolving Inconsistent Findings

    Microsoft Academic Search

    Timothy D. Golden; John F. Veiga

    2005-01-01

    Although popular management wisdom has suggested that telecommuting enhances job satisfaction, research has found both positive and negative relationships. In this study, the authors attempt to resolve these inconsistent findings by hypothesizing a curvilinear, inverted U-shaped relationship between the extent of telecommuting and job satisfaction. Using hierarchical regression analysis on a sample of 321 professional-level employees, their findings suggest a

  2. Implicit memory functioning in schizophrenia: Explaining inconsistent findings of word stem completion tasks.

    PubMed

    Soler, María José; Ruiz, Juan Carlos; Dasí, Carmen; Fuentes-Durá, Inma

    2015-03-30

    The definitive implicit memory profile of schizophrenia is yet to be clarified. Methodological differences between studies could be the reason for the inconsistent findings reported. In this study, we have examined implicit memory functioning using a word stem completion task. In addition, we have addressed methodological issues related with lexical and perceptual stimuli characteristics, and with the strategy used to calculate priming scores. Our data show similar performance values in schizophrenic patients and healthy controls. Furthermore, we have not detected significant differences in priming between the two groups, even when this parameter was calculated using three different procedures. These results are in line with those we have reported previously using the same stimuli in a word fragment completion task. Considered as a whole, our research suggests that implicit memory functioning in schizophrenia is unimpaired when assessed using word fragment or stem completion tasks. In light of this, future studies should follow standardized criteria to assess implicit memory when the sensitivity of the task employed is essential for identifying potential memory deficits in schizophrenia. PMID:25667118

  3. Inconsistency Management in Software Engineering: Survey and Open Research Issues

    Microsoft Academic Search

    George Spanoudakis; Andrea Zisman

    2001-01-01

    The development of complex software systems is a complex and lengthy activity that involves the participation and collaboration of many stakeholders (e.g. customers, users, analysts, designers, and developers). This results in many partial models of the developing system. These models can be inconsistent with each other since they describe the system from different perspectives and reflects the views of the

  4. Inconsistent findings for the eyes closed effect in children: the implications for interviewing child witnesses

    PubMed Central

    Kyriakidou, Marilena; Blades, Mark; Carroll, Dan

    2014-01-01

    A child who alleges that they have been the victim of a crime will be interviewed by police officers. During a police interview it is important that the interviewer obtains the most accurate testimony possible from the child. Previous studies have shown that if children have their eyes closed during an interview they sometimes report more correct information. This paper includes two studies. In Experiment 1 156 children experienced an event and were then questioned about it. Half the children answered with their eyes open and half with their eyes closed. The participants with eyes closed provided more correct information. In Experiment 2 152 children answered questions in different conditions including eyes open and eyes closed conditions. In contrast to Experiment 1 there was no beneficial effect for the eyes closed condition. These inconsistent results are discussed with reference to actual police interviews. It is suggested that until there has been more research into eyes closed procedures caution should be taken in recommending such procedures for police interviews with children. PMID:24999333

  5. RESEARCH FINDINGS BASIC NEUROSCIENCES RESEARCH

    E-print Network

    Bandettini, Peter A.

    RESEARCH FINDINGS BASIC NEUROSCIENCES RESEARCH Cocaine Dynamically Regulates Heterochromatin and Repetitive Element Unsilencing In Nucleus Accumbens Repeated cocaine exposure induces persistent alterations on drug-mediated effects occurring throughout active euchromatic regions of the genome, with very little

  6. RESEARCH FINDINGS BASIC NEUROSCIENCE RESEARCH

    E-print Network

    Bandettini, Peter A.

    1 RESEARCH FINDINGS BASIC NEUROSCIENCE RESEARCH MR Imaging in Conscious Monkeys Functional magnetic, both in human and nonhuman subjects. Preclinical fMRI studies have several advantages; for example disadvantage of preclinical fMRI to date has been the necessity to conduct the scanning in anesthetized animals

  7. Breast Cancer Research Finding Answers. Finding Cures.

    E-print Network

    Kowalczykowski, Stephen C.

    Breast Cancer Research Finding Answers. Finding Cures. Thanks to improvements in treatment and early detection, more and more women are surviving breast cancer. In fact, the five-year survival rate for women with breast cancer today is 90%, up from only 63% in the 1960s. While progress has clearly been

  8. Inconsistency in the strength testing of dental resin-based composites among researchers

    PubMed Central

    Kumar, Naresh

    2013-01-01

    The aims of this paper were to review the current strength testing methods of the dental resin-based composites (RBCs) and to explore the inconsistencies with regard to strength testing among researchers. Data selection/extraction: An outline of the most relevant aspects of RBCs was created, and a subsequent literature search for articles published during last four decades (1970-2010) was conducted using the databases, namely PubMed, Science Direct and ISI Web of Knowledge. Conclusion: The literature review highlighted a lack of consensus among researchers regarding the reliability of ISO recommended three-point flexure strength testing method. Several investigators have used Weibull statistics for the analysis of RBCs strength data, however their applicability might be questioned as many RBCs contain greater resin content and may exhibit sufficient viscous deformation prior to brittle failure. In addition, variability in the selection of cross-head speed and mould material for strength testing was evident which may lead to variation in the strength data and render the interpretation difficult among researchers. PMID:24353541

  9. Inconsistencies in Quality of Life Data Collection in Clinical Trials: A Potential Source of Bias? Interviews with Research Nurses and Trialists

    PubMed Central

    Kyte, Derek; Ives, Jonathan; Draper, Heather; Keeley, Thomas; Calvert, Melanie

    2013-01-01

    Background Patient-reported outcomes (PROs), such as health-related quality of life (HRQL) are increasingly used to evaluate treatment effectiveness in clinical trials, are valued by patients, and may inform important decisions in the clinical setting. It is of concern, therefore, that preliminary evidence, gained from group discussions at UK-wide Medical Research Council (MRC) quality of life training days, suggests there are inconsistent standards of HRQL data collection in trials and appropriate training and education is often lacking. Our objective was to investigate these reports, to determine if they represented isolated experiences, or were indicative of a potentially wider problem. Methods And Findings We undertook a qualitative study, conducting 26 semi-structured interviews with research nurses, data managers, trial coordinators and research facilitators involved in the collection and entry of HRQL data in clinical trials, across one primary care NHS trust, two secondary care NHS trusts and two clinical trials units in the UK. We used conventional content analysis to analyze and interpret our data. Our study participants reported (1) inconsistent standards in HRQL measurement, both between, and within, trials, which appeared to risk the introduction of bias; (2), difficulties in dealing with HRQL data that raised concern for the well-being of the trial participant, which in some instances led to the delivery of non-protocol driven co-interventions, (3), a frequent lack of HRQL protocol content and appropriate training and education of trial staff, and (4) that HRQL data collection could be associated with emotional and/or ethical burden. Conclusions Our findings suggest there are inconsistencies in the standards of HRQL data collection in some trials resulting from a general lack of HRQL-specific protocol content, training and education. These inconsistencies could lead to biased HRQL trial results. Future research should aim to develop HRQL guidelines and training programmes aimed at supporting researchers to carry out high quality data collection. PMID:24124580

  10. Teacher Retirement Systems: Research Findings. Research Brief

    ERIC Educational Resources Information Center

    Hansen, Janet S.; Podgursky, Michael J.; Costrell, Robert M.

    2009-01-01

    This policy brief summarizes findings presented at a February 2009 research conference on teacher retirement systems hosted by the National Center on Performance Incentives (NCPI) at Vanderbilt University's Peabody College. The 2009 conference was the second in a series of NCPI events focusing on findings from recent research on issues related to…

  11. RESEARCH GIVES EDGE TO FINDING

    E-print Network

    Angenent, Lars T.

    home revisited. COVER STORY Séamus Davis and the path to faculty renewal BY BILL STEELE A look at what the Nano' explores a revolution in design and transportation BY DANIEL ALOI RESEARCH SPOTLIGHT $80 million the publisher Cornell's Ithaca campus is about to experience a tectonic shift. In the coming decade, as the baby

  12. Finding Fault? Exploring Legal Duties to Return Incidental Findings in Genomic Research

    PubMed Central

    Pike, Elizabeth R.; Rothenberg, Karen H.; Berkman, Benjamin E.

    2014-01-01

    The use of whole-genome sequencing in biomedical research is expected to produce dramatic advances in human health. The increasing use of this powerful, data-rich new technology in research, however, will inevitably give rise to incidental findings (IFs)—findings with individual health or reproductive significance that are beyond the aims of the particular research—and the related questions of whether and to what extent researchers have an ethical obligation to return IFs. Many have concluded that researchers have an ethical obligation to return some findings in some circumstances but have provided vague or context-dependent approaches to determining which IFs must be returned and when. As a result, researchers have started returning IFs inconsistently, giving rise to concerns about legal liability in circumstances in which notification could have potentially prevented injury. Although it is clear that ethical guidance should not be automatically codified as law and that crafting ethical obligations around legal duties can be inappropriate, the ethical debate should not proceed unaware of the potential legal ramifications of advancing and implementing an ethical obligation to return IFs. This Article assesses the legal claims that could be brought for a researcher’s failure to return IFs. The potential for researchers to be held liable in tort is still uncertain and turns largely on a number of factors—including customary practice and guidance documents—that are still in flux. Unlike medical care, which has a well-defined duty into which evolving scientific knowledge about genetics and genomics can readily be incorporated, a researcher’s duty to return IFs is less well defined, making it difficult to determine at the outset whether and when legal liability will attach. This Article advocates for a clearer, ethically sound standard of requiring that researchers disclose in the informed consent document which approach to offering IFs will be taken. This approach enables participants to know at the outset which findings, if any, will be returned, allows researchers to ascertain when their failure to appropriately return incidental findings will give rise to liability, and enables courts to make determinations that will produce more consistent legal guidance. PMID:25346543

  13. Finding Fault? Exploring Legal Duties to Return Incidental Findings in Genomic Research.

    PubMed

    Pike, Elizabeth R; Rothenberg, Karen H; Berkman, Benjamin E

    2014-01-01

    The use of whole-genome sequencing in biomedical research is expected to produce dramatic advances in human health. The increasing use of this powerful, data-rich new technology in research, however, will inevitably give rise to incidental findings (IFs)-findings with individual health or reproductive significance that are beyond the aims of the particular research-and the related questions of whether and to what extent researchers have an ethical obligation to return IFs. Many have concluded that researchers have an ethical obligation to return some findings in some circumstances but have provided vague or context-dependent approaches to determining which IFs must be returned and when. As a result, researchers have started returning IFs inconsistently, giving rise to concerns about legal liability in circumstances in which notification could have potentially prevented injury. Although it is clear that ethical guidance should not be automatically codified as law and that crafting ethical obligations around legal duties can be inappropriate, the ethical debate should not proceed unaware of the potential legal ramifications of advancing and implementing an ethical obligation to return IFs. This Article assesses the legal claims that could be brought for a researcher's failure to return IFs. The potential for researchers to be held liable in tort is still uncertain and turns largely on a number of factors-including customary practice and guidance documents-that are still in flux. Unlike medical care, which has a well-defined duty into which evolving scientific knowledge about genetics and genomics can readily be incorporated, a researcher's duty to return IFs is less well defined, making it difficult to determine at the outset whether and when legal liability will attach. This Article advocates for a clearer, ethically sound standard of requiring that researchers disclose in the informed consent document which approach to offering IFs will be taken. This approach enables participants to know at the outset which findings, if any, will be returned, allows researchers to ascertain when their failure to appropriately return incidental findings will give rise to liability, and enables courts to make determinations that will produce more consistent legal guidance. PMID:25346543

  14. Graphic organizers in reading instruction: Research findings and issues

    Microsoft Academic Search

    Xiangying Jiang; William Grabe

    2007-01-01

    As an instructional tool, graphic organizers (GOs) have been highly recommended and used in contemporary classrooms. Over the past decade, a number of concerns have been raised about claims for the effectiveness of GOs. These concerns involve the inconsistent research results on student improvements, the limitation in generalizability from research studies, and the need for research studies with second language

  15. Learning from Inconsistency

    NASA Technical Reports Server (NTRS)

    Easterbrook, Steve

    1996-01-01

    This position paper argues that inconsistencies that occur during the development of a software specification offer an excellent way of learning more about the development process. We base this argument on our work on inconsistency management. Much attention has been devoted recently to the need to allow inconsistencies to occur during software development, to facilitate flexible development strategies, especially for collaborative work. Recent work has concentrated on reasoning in the presence of inconsistency, tracing inconsistencies with 'pollution markers' and supporting resolution. We argue here that one of the most important aspects of inconsistency is the learning opportunity it provides. We are therefore concerned with how to capture this learning outcome so that its significance is not lost. We present a small example of how apprentice software engineers learn from their mistakes, and outline how an inconsistency management tool could support this learning. We then argue that the approach can be used more generally as part of continuous process improvement.

  16. Prejudice Reduction and the Findings of Research.

    ERIC Educational Resources Information Center

    Pate, Glenn S.

    Research studies that have investigated the effects of interventions aimed at reducing prejudice are reviewed, and a synthesis of their findings is presented. Some generalizations are offered that have the potential to lead towards a less prejudiced society. Research is summarized according to the intervention approaches used in the following…

  17. Women in Mixed Groups: Some Research Findings.

    ERIC Educational Resources Information Center

    Mamola, Claire

    1979-01-01

    Reviews the research dealing with women in leadership roles within groups of both sexes. Some research indicates a reluctance of women to assume leadership roles. Other findings indicate women are more likely to be strong leaders when the task solution is given. (LPG)

  18. Prisons Research Centre Annual Report and Research Findings 2009

    E-print Network

    Travis, Adrian

    Prisons Research Centre Annual Report and Research Findings 2009 The Prisons Research Centre is now from the Prison Service, the Nuffield Foundation, the Leverhulme Trust, the ESRC, The KPMG Foundation by previous research by both investigators, and drew upon their expertise in the analysis of prison life

  19. Tools for Finding Indexed Accounting Research

    NSDL National Science Digital Library

    The American Accounting Association (AAA) lists the print resources and electronic databases where AAA journals are indexed and abstracted at this Tools for Finding Indexed Accounting Research page. The detailed list includes indexing and abstracting devices for a number of journals -- Accounting Horizons, The Accounting Review, Auditing: A Journal of Practice & Theory, Behavioral Research in Accounting, Issues in Accounting Education, Journal of the American Taxation Association, Journal of Information Systems, and the Journal of Management Accounting Research -- with date coverage and full-text information included for each.

  20. Space Situational Awareness (SSA) research findings

    Microsoft Academic Search

    David Richmond; Valley Forge PA

    2008-01-01

    Space Situational Awareness (SSA) is the foundation for space superiority and has become a national priority. Providing full SSA requires knowledge of space and ground assets along with communication links between these assets. It also requires an understanding of potential events and threats that may affect these assets. This paper summarizes the findings resulting from a research environment established to

  1. Americans' Gut Bacteria Lack Diversity, Researchers Find

    MedlinePLUS

    ... person due to better sanitation and cleaner drinking water in the United States, the researchers reported in the journal Cell Reports . "These findings suggest that lifestyle practices that reduce bacterial dispersal ... and drinking-water treatment -- might be an important cause of microbiome ...

  2. Prisons Research Centre Annual Report on Research Findings 2010

    E-print Network

    Travis, Adrian

    Prisons Research Centre Annual Report on Research Findings 2010 The Prisons Research Centre is now from the Prison Service, the Nuffield Foundation, the Leverhulme Trust, the ESRC, The KPMG Foundation study of four matched public and private sector prisons (and three additional establishments). The main

  3. Graphic Organizers in Reading Instruction: Research Findings and Issues

    ERIC Educational Resources Information Center

    Jiang, Xiangying; Grabe, William

    2007-01-01

    As an instructional tool, graphic organizers (GOs) have been highly recommended and used in contemporary classrooms. Over the past decade, a number of concerns have been raised about claims for the effectiveness of GOs. These concerns involve the inconsistent research results on student improvements, the limitation in generalizability from…

  4. Researcher as Instrument: Understanding "Shifting" Findings in Constructivist Research

    ERIC Educational Resources Information Center

    Stewart, Dafina Lazarus

    2010-01-01

    Two studies investigating the meaning and articulation of multiple identities among Black college students revealed shifts in the findings from the 2001 study to the 2005 study. This theoretical review explores the role of the researcher as instrument within the constructivist research paradigm as a possible explanation for some of these apparent…

  5. Researchers Find Japanese Submarine at Pearl Harbor

    NSDL National Science Digital Library

    Green, Marcia.

    2002-01-01

    Earlier this week, researchers from the University of Hawaii and the Hawaii Underwater Research Lab located the remains of a Japanese midget submarine. Found in 1200 feet of water, the submarine was sunk by the USS Ward just an hour before the aerial attack on Pearl Harbor on December 7, 1941. Most important, the discovery of the midget submarine offers concrete physical evidence that the United States did fire the first shot against the Japanese. Previous expeditions to locate the sub, including an effort made in 2000 by the National Geographic Society, had been unsuccessful, largely due to the fact that the area is a military "junkyard" with tons of debris on the ocean floor.For more in-depth information on this story, readers may find the first four news links particularly helpful. The fifth link leads to the Hawaii Underwater Research Lab's Web site that features photographs of the midget sub from the expedition earlier this week. The sixth link is to a Web site dealing with the history and missions of the USS Ward. The final link contains detailed information about the 2000 expedition led by Robert Ballard, with support from the National Geographic Society, to find the midget submarine.

  6. Symptoms of Eating Disorders Among Female Distance Runners: Can the Inconsistencies Be Unraveled?

    Microsoft Academic Search

    Donald H. Ryujin; Cynthia Breaux; Amanda D. Marks

    2000-01-01

    Research on eating disorders among female distance runners has produced a modest, but inconsistent body of findings. To unravel the confusion, we hypothesized a model whereby studies finding greater symptomatology have involved obligatory runners or elite national\\/international competitors. Studies not finding greater symptomatology have involved a more typical group of athletes. To test our hypothesis, we used the Eating Disorders

  7. Space Situational Awareness (SSA) research findings

    NASA Astrophysics Data System (ADS)

    Richmond, D.

    Space Situational Awareness (SSA) is the foundation for space superiority and has become a national priority. Providing full SSA requires knowledge of space and ground assets along with communication links between these assets. It also requires an understanding of potential events and threats that may affect these assets. This paper summarizes the findings resulting from a research environment established to explore SSA issues. Non-traditional data sources available on the internet are identified along with methods to mine relevant data. Algorithms to augment this data with value added processing were evaluated and key features are presented. These include all-on-all conjunction analysis utilizing analytical distributed processing approaches and maneuver detection utilizing an approach described in the AMOS 2007 paper "Satellite Maneuver Detection Using Two-line Elements". Data fusion techniques are presented which were utilized to evaluate space launches, enhance maneuver detection capabilities, characterize events and determine possible intent. Several visualization approaches were explored and the key features/limitations are discussed to include performance consideration, event models between visualization components, and data needs at the tactical, operational, and strategic levels. Data dissemination approaches utilizing a Service Oriented Architecture (SOA) are highlighted along with challenges such as Multiple Levels of Security associated with the data. Dependencies between visualization and dissemination that impact the system's performance are discussed. Alternatives to balance system performance and application of a User Defined Operational Picture (UDOP) are explored.

  8. Animal Research: Finding Cures, Saving Lives

    NSDL National Science Digital Library

    2010-06-24

    This website provides an online and a printable brochure that provides information on why researchers study animals, how research animals are cared for, the ethics of animal research, cosmetic testing on animals, and how animal research helps people in the context of a diabetes patient.

  9. Russian research capabilities: Findings of site visits

    SciTech Connect

    Wester, D.W.

    1994-02-01

    In June 1993, a proposal was presented to the International Environmental Institute (IEI) in Kennewick, Washington, to establish cooperation and coordination to further pursue the interests of the United States of America and the Republic of Russia in the application and promotion of environmental technology; characterization, treatment, handling, isolation, and disposal of hazardous and radioactive materials; conversion of defense sites to other purposes; and technology transfer, cooperative programs, joint technology development and contractual research. In response to this proposal, IEI and Pacific Northwest Laboratory (PNL) jointly provided funding to send Dr. Dennis W. Wester on a fact-finding mission to Novosibirsk, Moscow, and St. Petersburg, Russia. The trip covered a period of eight weeks, six of which were spent in Novosibirsk and adjoining or related cities and one of which was spent in each of Moscow and St. Petersburg. The general objectives of the trip were to establish a basis for cooperation between IEI and the Russian Academy of Sciences (RAS) for future coordination of mutual interests and objectives such as technology acquisition, development, demonstration, application, and commercialization; use of capabilities and assets developed by the U.S. Department of Energy (DOE) and the RAS; and expediting of cooperative agreements, personnel exchanges, joint ventures and other contractual relationships. The particular objectives of this trip were to evaluate the capabilities of the RAS to satisfy the technology needs associated with the cleanup of the Hanford Site and similar sites in the U.S. and to evaluate the expediency of establishing an IEI presence in Russia.

  10. 75 FR 18837 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ...former senior scientist, Discovery Research, Women's Health, Wyeth Pharmaceuticals, engaged in research misconduct...phosphorylation cascades) that is of importance to women's health. Dr. Cheskis' team identified an adapter...

  11. 76 FR 61361 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ...research misconduct by (1) plagiarizing text and falsifying data from two publications...significant portions of that plagiarized text in two grant applications to the National...in research misconduct by plagiarizing text, falsifying data and references,...

  12. 78 FR 67363 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ...analysis, ORI found that Dr. Hao Wang, former Associate Professor of Surgery and Pathology, Schulich School of Medicine and Dentistry, WU, engaged in research misconduct in research supported by National Institute of Allergy and Infectious Diseases...

  13. 78 FR 72892 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-04

    ...Respondent engaged in research misconduct by fabricating...referred to as the ``CEBP paper''). Specifically...in Table 1 of the CEBP paper and falsely reported...conclusions of the CEBP paper are based on fabricated...2013: (1) To have his research supervised;...

  14. 77 FR 124 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-03

    ...similar experiments in four laboratory meeting presentations. The purpose of the falsifications...PHS funds, or report, manuscript, or abstract involving PHS supported research in which...application, report, manuscript, or abstract; and (3) to exclude herself from...

  15. 75 FR 39530 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ...dogs with X-linked progressive retinal atrophy in abstracts and poster presentations for the 2006 \\1\\ and 2007...Association for Research in Vision and Ophthalmology (ARVO) meetings and in an unsubmitted manuscript...

  16. 77 FR 11538 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ...setting forth the committee meeting dates, Respondent's compliance...submitted for publication, and abstracts; the review will include a...or report, manuscript, or abstract involving PHS-supported research...report, manuscript, or abstract; and (4) To exclude...

  17. Tobacco Smoke Strengthens 'Superbug,' Lab Research Finds

    MedlinePLUS

    ... the infection, researchers from the University of California, San Diego School of Medicine found. "We already know ... an assistant clinical professor of medicine at UC San Diego, said in a university news release. However, ...

  18. 77 FR 125 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-03

    ...Assistant Professor in the K- INBRE \\1\\ Bioinformatics Core Facility, KU, engaged in research...International Joint Conference on Bioinformatics, Systems, Biology and Intelligent...the IEEE International Conference on Bioinformatics and Biomedicine Workshop,...

  19. 77 FR 52034 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

    ...Department of Developmental and Stem Cell Biology, Joslin, engaged in research...ageing and rejuventation of blood stem cell niches.'' Nature 463:495-500...niche cells initiate hemotopoietic stem cell mobilization.'' Blood...

  20. 75 FR 18836 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ...figures identified below in specific grant applications and published papers are false and that these falsifications rise to the level of research misconduct: Respondent admitted to falsifying Figures 6B, 18, 22, 23B, and 24 in NCCAM,...

  1. Writing and Publishing Your Research Findings

    PubMed Central

    Quinn, Charles T.; Rush, A. John

    2014-01-01

    Writing clearly is critical to the success of your scientific career. Unfortunately, this skill is not taught in medical school or postgraduate training. This article summarizes our approach to the writing and publication of your research. Here we focus on empirical or experimental reports of translational and clinically oriented research. We review the process of choosing what to write, how to write it clearly, and how to navigate the process of submission and publication. PMID:19491626

  2. 79 FR 22973 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2014-04-25

    ...falsified experimental data for LacZ stained liver sections and for hematoxylin and eosin (H&E) stained liver sections. Specifically, ORI finds by...phenylalanine after PKU gene therapy and to show liver levels of BH 4 when the Respondent...

  3. Educational Research: Biologists Finding Their Voice

    ERIC Educational Resources Information Center

    Orsmond, Paul

    2007-01-01

    Since the publication of the Dearing report (1997) there has been an increasing emphasis on the quality of teaching and learning provision within higher education institutions (HEIs). This focus on provision has in turn generated much educational research into "approaches" to both teaching practice and student learning within higher education…

  4. 75 FR 77641 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ...thus, I could not be certain of the exact identity of the plasmids in question.'' ORI found that Dr. Mungekar engaged in research...Mungekar also claimed to have constructed 53 different reporter plasmids with RNase E mutants, when sequencing data did not exist...

  5. Inconsistency in large pharmacogenomic studies

    PubMed Central

    El-Hachem, Nehme; Birkbak, Nicolai Juul; Jin, Andrew C.; Beck, Andrew H.; Aerts, Hugo J.W.L.; Quackenbush, John

    2014-01-01

    Cancer cell line studies have long been used to test efficacy of therapeutic agents and to explore genomic factors predictive of response1,2. Two large-scale pharmacogenomic studies were published recently3,4; each assayed a panel of several hundred cancer cell lines for gene expression, copy number, genome sequence, and pharmacological response to multiple anti-cancer drugs. The resulting datasets present a unique opportunity to characterize mechanisms associated with drug response, with 471 cell lines and 15 drugs assayed in both. However, while gene expression is well correlated between studies, the measured pharmacologic drugs response is highly discordant. This poor correspondence is surprising as both studies assessed drug response using common estimators: the IC50 (concentration at which the drug inhibited 50% of the maximal cellular growth), and the AUC (area under the activity curve measuring dose response)5. For drugs screened in both studies, only one had a Spearman correlation coefficient in measured response greater than 0.6. Importantly these results are also reflected in inconsistent associations between genomic features and drug response. Although the source of inconsistencies in drug response measures between these two well-controlled studies remains uncertain, it makes drawing firm conclusions about response very difficult and has potential implications for using these outcome measures to assess gene-drug relationships or select potential anti-cancer drugs based on their reported results. Our findings suggest standardization of response measurement protocols in pharmacogenomic studies is essential before such studies can live up to their promise. PMID:24284626

  6. Managing incidental findings in human subjects research: analysis and recommendations.

    PubMed

    Wolf, Susan M; Lawrenz, Frances P; Nelson, Charles A; Kahn, Jeffrey P; Cho, Mildred K; Clayton, Ellen Wright; Fletcher, Joel G; Georgieff, Michael K; Hammerschmidt, Dale; Hudson, Kathy; Illes, Judy; Kapur, Vivek; Keane, Moira A; Koenig, Barbara A; Leroy, Bonnie S; McFarland, Elizabeth G; Paradise, Jordan; Parker, Lisa S; Terry, Sharon F; Van Ness, Brian; Wilfond, Benjamin S

    2008-01-01

    No consensus yet exists on how to handle incidental findings (IFs) in human subjects research. Yet empirical studies document IFs in a wide range of research studies, where IFs are findings beyond the aims of the study that are of potential health or reproductive importance to the individual research participant. This paper reports recommendations of a two-year project group funded by NIH to study how to manage IFs in genetic and genomic research, as well as imaging research. We conclude that researchers have an obligation to address the possibility of discovering IFs in their protocol and communications with the IRB, and in their consent forms and communications with research participants. Researchers should establish a pathway for handling IFs and communicate that to the IRB and research participants. We recommend a pathway and categorize IFs into those that must be disclosed to research participants, those that may be disclosed, and those that should not be disclosed. PMID:18547191

  7. Editorial Decisions May Perpetuate Belief in Invalid Research Findings

    PubMed Central

    Eriksson, Kimmo; Simpson, Brent

    2013-01-01

    Social psychology and related disciplines are seeing a resurgence of interest in replication, as well as actual replication efforts. But prior work suggests that even a clear demonstration that a finding is invalid often fails to shake acceptance of the finding. This threatens the full impact of these replication efforts. Here we show that the actions of two key players – journal editors and the authors of original (invalidated) research findings – are critical to the broader public’s continued belief in an invalidated research conclusion. Across three experiments, we show that belief in an invalidated finding falls sharply when a critical failed replication is published in the same – versus different – journal as the original finding, and when the authors of the original finding acknowledge that the new findings invalidate their conclusions. We conclude by discussing policy implications of our key findings. PMID:24023863

  8. Finding our Future: A Research Agenda for the Research Enterprise

    Microsoft Academic Search

    Theresa A. Pardo; Sharon S. Dawes; Anthony M. Cresswell; Fiona Thompson; Giri Kumar Tayi

    2003-01-01

    Abstract The NSF Digital Government research program helps to develop new research themes by sponsoring preliminary explorations and workshops to outline emerging areas of inquiry One area which was recently explored in this way is the grants making and grants management process by which the federal government distributes more than $100 billion each year The project included focus groups and

  9. Researchers Find Essential Brain Circuit in Visual Development

    MedlinePLUS

    ... 2013 Researchers find essential brain circuit in visual development NIH-funded study could lead to new treatments ... adulthood. “Our study identifies a mechanism for visual development in the young brain and shows that it’s ...

  10. Smoking Linked to Damage in the Brain, Researchers Find

    MedlinePLUS

    ... sharing features on this page, please enable JavaScript. Smoking Linked to Damage in the Brain, Researchers Find ... February 13, 2015 Related MedlinePlus Pages Brain Diseases Smoking FRIDAY, Feb. 13, 2015 (HealthDay News) -- Smoking may ...

  11. Findings

    NSDL National Science Digital Library

    Starting in February 2001, the National Institute of General Medical Sciences (NIGMS) began publishing "Findings" magazine. The publication features research and findings from scholars doing work with funding from the NIGMS. Visitors can browse the archive of the publication by topic or date, and they can also check out the sample articles from the latest edition on the homepage. Recent pieces have included "Drugs from Deep Down", "Mesmerized by Metals", and "Just Found", which talks about potential sunburn treatments. The site also has the "Find More" area, which contains an image gallery, school resources, free slide kits, and interactive games. Also, the "Watch" area contains interviews with scientists like Dr. Kevin Tracey talking about his investigations into sepsis. Finally, visitors can also sign up to receive Findings via email.

  12. Multiple Perpetrator Rape: Naming an Offence and Initial Research Findings

    ERIC Educational Resources Information Center

    Horvath, Miranda Angel Helena; Kelly, Liz

    2009-01-01

    Multiple perpetrator rape presents a significant problem nationally and internationally. However, previous research is limited and findings are often contradictory. The details of 101 rape allegations recorded in a six-month period in a large police force in England were analysed. Findings are presented about case classification, victim and…

  13. Delinquent-Oriented Attitudes Mediate the Relation Between Parental Inconsistent Discipline and Early Adolescent Behavior

    PubMed Central

    Halgunseth, Linda C.; Perkins, Daniel F.; Lippold, Melissa A.; Nix, Robert L.

    2013-01-01

    Although substantial research supports the association between parental inconsistent discipline and early adolescent behaviors, less is understood on mechanisms underlying this relation. This study examined the mediating influence of delinquent-oriented attitudes in early adolescence. Using a longitudinal sample of 324 rural adolescents and their parents, findings revealed that inconsistent discipline in 6th grade predicted an increase in adolescent delinquent-oriented attitudes by 7th grade which, in turn, predicted both an increase in early adolescent antisocial behaviors and a decrease in socially competent behaviors by 8th grade. Therefore, it appears that accepting attitudes toward delinquency may in part develop from experiencing inconsistent discipline at home and may offer a possible explanation as to why early adolescents later engage in more antisocial and less socially competent behaviors. Findings may inform family-based preventive intervention programs that seek to decrease behavior problems and promote social competence in early adolescents. PMID:23544924

  14. Case Western researchers present new findings for glioblastoma

    Cancer.gov

    Physician-scientists from University Hospitals (UH), Case Medical Center's Seidman Cancer Center and Case Western Reserve University School of Medicine presented new research findings this week at the Annual Meeting of the American Association for Cancer Research (AACR) in Chicago. One study sought to identify protein biomarkers that can help physicians determine which patients may benefit from standard treatment for GBM.

  15. Science Teachers' Awareness of Findings from Education Research.

    ERIC Educational Resources Information Center

    Costa, Nilza; Marques, Luis; Kempa, Richard

    2000-01-01

    Reports on a small-scale study designed to estimate science teachers' awareness of findings derived from research in science education and other branches of educational research. Focuses on experienced science teachers in Portugal who were following advanced professional training programs that usually lead to Masters' degrees in science education.…

  16. Yale researchers find genes behind aggressive endometrial cancer

    Cancer.gov

    Yale and Yale Cancer Center researchers have defined the genetic landscape of uterine serous carcinoma (USC) tumors, a chemo-resistant, aggressive form of endometrial cancer, findings that point to new treatment opportunities. The collaborative team—which included researchers with expertise in gynecological cancer, genomics, and computational biology— identified a number of new genes that are frequently mutated in USC.

  17. Environmentally Mediated Risks for Psychopathology: Research Strategies and Findings

    ERIC Educational Resources Information Center

    Rutter, Michael

    2005-01-01

    Objective: To consider the research design requirements needed to provide a rigorous test of environmental mediation hypotheses and to summarize the main findings from research using such designs. Method: Selective review of empirical evidence dealing with psychopathology. Results: There is robust evidence of environmentally mediated risks for…

  18. The Role of Inconsistent Ideas in Learning Mathematics.

    ERIC Educational Resources Information Center

    Georgia Univ., Athens. Dept. of Mathematics Education.

    This document presents four research papers related to the role of inconsistent ideas in learning mathematics and a discussion paper related to the same issue. The titles of the papers are: (1) "Cognitive Conflict in Procedure Applications" (Merlyn Behr and Guershon Harel); (2) "Inconsistencies in Preservice Elementary Teachers' Beliefs and about…

  19. Inconsistencies in Autism-Specific Emotion Interventions: Cause for Concern

    ERIC Educational Resources Information Center

    Caldeira, Monica; Edmunds, Alan

    2012-01-01

    Precise educational interventions are the sine qua non of services for students with exceptionalities. Applying interventions riddled with inconsistencies, therefore, interferes with the growth and learning potential of students who need these interventions. This research synthesis documents the inconsistencies revealed during a critical analysis…

  20. Recruiting Underserved Mothers to Medical Research: Findings from North Carolina

    PubMed Central

    Spears, Chaya R.; Sandberg, Joanne C.; O’Neill, Jenna L.; Grzywacz, Joseph G.; Howard, Timothy D.; Feldman, Steven R.; Arcury, Thomas A.

    2014-01-01

    Representative samples are required for ethical, valid, and useful health research. Yet, recruiting participants, especially from historically underserved communities, can be challenging. This paper presents findings from in-depth interviews with 40 mothers about factors that might influence their willingness to participate or allow their children to participate in medical research. Saliency analysis organizes the findings. Frequent and important salient themes about research participation included concerns that it might cause participants harm, hope that participants might gain a health benefit, and recognition that time and transportation resources could limit participation. Ultimately, we propose that a theoretical model, such as the Theory of Planned Behavior (TPB), will facilitate more systematic evaluation of effective methods for recruitment and retention of participants in medical research. Future research should explore the utility of such a model for development of effective recruitment and retention strategies. PMID:24185171

  1. In Search of New Ideas, Research Findings, and Emerging Technologies? Here's Where To Find Them.

    ERIC Educational Resources Information Center

    Powell, Gary C.

    There are many avenues available to computer-assisted instruction (CAI) practitioners and developers in search of access to new ideas, research findings, and emerging technologies that will assist them in developing CAI products. Seven such avenues are described in detail: (1) graduate student interns, who bring unique insights, theory, and…

  2. September 17, 2010 LSUHSC research finds cause & remedy for learning &

    E-print Network

    of medical marijuana LSUHSC research finds combo of plant nutrients kills breast cancer cells Chancellor a study that identified the cause of learning and memory deficits associated with medical marijuana use that inhibit COX-2 prevented these debilitating side effects. The results suggest the use of medical marijuana

  3. Recreation ecology research findings: Implications for wilderness and park managers

    USGS Publications Warehouse

    Marion, J.L.

    1998-01-01

    Recreationists unintentionally trample vegetation, erode soil, and disturb wildlife. Such human-related impacts present a dilemma for managers charged with the dual objectives of providing recreational opportunities and preserving natural environments. This paper presents some of the principal findings and management implications from research on visitor impacts to protected areas, termed recreation ecology research. This field of study seeks to identify the type and extent of resource impacts and to evaluate relationships between use-related, environmental, and managerial factors. The capabilities and managerial utility of recreation impact monitoring are also described.

  4. Research Infusion Collaboration: Finding Defect Patterns in Reused Code

    NASA Technical Reports Server (NTRS)

    Lutz, Robyn R.; Morgan, Scott; Do, Tuan; Mikulski, Carmen; Berg Strain, Martha; Rockwell, Steve; Wilkinson, Belinda

    2004-01-01

    The 'Finding Defect Patterns in Reused Code' Research Infusion Collaboration was performed by Jet Propulsion Laboratory/Caltech under Contract 104-07-02.679 102 197 08.14.4. This final report describes the collaboration and documents the findings, including lessons learned.The research infusion collaboration characterized, using Orthogonal Defect Classification, defect reports for code that will be reused in mission-critical software on Deep Space Network Antenna controllers. Code reuse is estimated to be 90%, so it is important to identify systemic defects, or patterns, prior to reuse of this code. The work also identified ways to avoid certain types of defects and to test more efficiently.The primary objectives of the project were:to analyze defect patterns of the code to be reused based on the defects'Orthogonal Defect Classification (ODC)and to achieve a successful infusion of ODC to a project.

  5. Vanderbilt researchers find a protein family key to aging, cancer:

    Cancer.gov

    The list of aging-associated proteins known to be involved in cancer is growing longer, according to research by investigators at Vanderbilt-Ingram Cancer Center and the National Institutes of Health. The new study, published Oct. 17 in Cancer Cell, identifies the protein SIRT2 as a tumor suppressor linked to gender-specific tumor development in mice. Along with two other "sirtuin" proteins previously linked to cancer, the new finding suggests the existence of a rare "family" of tumor suppressors.

  6. Research findings can change attitudes about corporal punishment.

    PubMed

    Holden, George W; Brown, Alan S; Baldwin, Austin S; Croft Caderao, Kathryn

    2014-05-01

    Positive attitudes toward the use of corporal punishment (CP) predict subsequent spanking behavior. Given that CP has frequently been associated with behavior problems in children and child maltreatment, this prevention work was designed to test whether adults' attitudes could be changed by informing participants about the research findings on problematic behaviors associated with CP. Two random assignment studies are reported. In Study 1, we tested whether an active reading condition would result in more attitude change than a passive condition. With a sample of 118 non-parent adults, we found that after reading very brief research summaries on the problems associated with CP, there was a significant decrease in favorable attitudes toward CP. Contrary to expectations, the magnitude of the change was comparable for active and passive processing conditions. In Study 2, we extended our approach to a sample of 520 parents and included a control group. A significant decrease in positive attitudes toward spanking was observed in the intervention group, but no change for the control group. Parents who were unaware of the research showed more change after reading the summaries. Thus, these studies demonstrate that a brief and cost-effective approach to raise awareness of research findings can reduce positive attitudes toward CP. Implications for prevention and intervention are discussed. PMID:24246718

  7. Children's contact with their incarcerated parents: research findings and recommendations.

    PubMed

    Poehlmann, Julie; Dallaire, Danielle; Loper, Ann Booker; Shear, Leslie D

    2010-09-01

    Approximately 1.7 million children have parents who are incarcerated in prison in the United States, and possibly millions of additional children have a parent incarcerated in jail. Many affected children experience increased risk for developing behavior problems, academic failure, and substance abuse. For a growing number of children, incarcerated parents, caregivers, and professionals, parent-child contact during the imprisonment period is a key issue. In this article, we present a conceptual model to provide a framework within which to interpret findings about parent-child contact when parents are incarcerated. We then summarize recent research examining parent-child contact in context. On the basis of the research reviewed, we present initial recommendations for children's contact with incarcerated parents and also suggest areas for future intervention and research with this vulnerable population. PMID:20822198

  8. Managing incidental findings and research results in genomic research involving biobanks and archived data sets.

    PubMed

    Wolf, Susan M; Crock, Brittney N; Van Ness, Brian; Lawrenz, Frances; Kahn, Jeffrey P; Beskow, Laura M; Cho, Mildred K; Christman, Michael F; Green, Robert C; Hall, Ralph; Illes, Judy; Keane, Moira; Knoppers, Bartha M; Koenig, Barbara A; Kohane, Isaac S; Leroy, Bonnie; Maschke, Karen J; McGeveran, William; Ossorio, Pilar; Parker, Lisa S; Petersen, Gloria M; Richardson, Henry S; Scott, Joan A; Terry, Sharon F; Wilfond, Benjamin S; Wolf, Wendy A

    2012-04-01

    Biobanks and archived data sets collecting samples and data have become crucial engines of genetic and genomic research. Unresolved, however, is what responsibilities biobanks should shoulder to manage incidental findings and individual research results of potential health, reproductive, or personal importance to individual contributors (using "biobank" here to refer both to collections of samples and collections of data). This article reports recommendations from a 2-year project funded by the National Institutes of Health. We analyze the responsibilities involved in managing the return of incidental findings and individual research results in a biobank research system (primary research or collection sites, the biobank itself, and secondary research sites). We suggest that biobanks shoulder significant responsibility for seeing that the biobank research system addresses the return question explicitly. When reidentification of individual contributors is possible, the biobank should work to enable the biobank research system to discharge four core responsibilities to (1) clarify the criteria for evaluating findings and the roster of returnable findings, (2) analyze a particular finding in relation to this, (3) reidentify the individual contributor, and (4) recontact the contributor to offer the finding. We suggest that findings that are analytically valid, reveal an established and substantial risk of a serious health condition, and are clinically actionable should generally be offered to consenting contributors. This article specifies 10 concrete recommendations, addressing new biobanks as well as those already in existence. PMID:22436882

  9. Maternal health and safe motherhood: findings from concluded research studies.

    PubMed

    1995-01-01

    The research component of the World Health Organization's Maternal Health and Safe Motherhood Program was established to provide new knowledge on scientifically valid and socially and economically acceptable ways of reducing high levels of maternal mortality and severe morbidity in order to achieve the global goal of reducing the level of maternal mortality by 50% by the year 2000. From the start of the program, more than 300 applications for support were received; 223 were submitted to the steering committee, of which 84 received funding. Not all of the studies have been completed. Among those studies which have been completed, however, several have been published in national and international journals, and some have been presented in a format generally inaccessible to those working in maternal health and safe motherhood. This paper introduces a special issue of World Health Statistics Quarterly which has brought together unpublished research results in the attempt to more widely disseminate research findings. A great deal of information has been obtained on levels of maternal mortality and morbidity in developing countries. Examples of health service and community interventions to improve maternal health have been identified, while information has accumulated on the main causes of maternal morbidity and mortality, hemorrhage, anemia, hypertensive disorders in pregnancy, sepsis, obstructed labor, and abortion. This valuable methodological and practical data have been collected despite constraints upon the scope and nature of the research and upon the methodologies used. PMID:7571705

  10. Managing Incidental Findings and Research Results in Genomic Research Involving Biobanks & Archived Datasets

    PubMed Central

    Wolf, Susan M.; Crock, Brittney N.; Van Ness, Brian; Lawrenz, Frances; Kahn, Jeffrey P.; Beskow, Laura M.; Cho, Mildred K.; Christman, Michael F.; Green, Robert C.; Hall, Ralph; Illes, Judy; Keane, Moira; Knoppers, Bartha M.; Koenig, Barbara A.; Kohane, Isaac S.; LeRoy, Bonnie; Maschke, Karen J.; McGeveran, William; Ossorio, Pilar; Parker, Lisa S.; Petersen, Gloria M.; Richardson, Henry S.; Scott, Joan A.; Terry, Sharon F.; Wilfond, Benjamin S.; Wolf, Wendy A.

    2013-01-01

    Biobanks and archived datasets collecting samples and data have become crucial engines of genetic and genomic research. Unresolved, however, is what responsibilities biobanks should shoulder to manage incidental findings (IFs) and individual research results (IRRs) of potential health, reproductive, or personal importance to individual contributors (using “biobank” here to refer to both collections of samples and collections of data). This paper reports recommendations from a 2-year, NIH-funded project. The authors analyze responsibilities to manage return of IFs and IRRs in a biobank research system (primary research or collection sites, the biobank itself, and secondary research sites). They suggest that biobanks shoulder significant responsibility for seeing that the biobank research system addresses the return question explicitly. When re-identification of individual contributors is possible, the biobank should work to enable the biobank research system to discharge four core responsibilities: to (1) clarify the criteria for evaluating findings and roster of returnable findings, (2) analyze a particular finding in relation to this, (3) re-identify the individual contributor, and (4) recontact the contributor to offer the finding. The authors suggest that findings that are analytically valid, reveal an established and substantial risk of a serious health condition, and that are clinically actionable should generally be offered to consenting contributors. The paper specifies 10 concrete recommendations, addressing new biobanks and biobanks already in existence. PMID:22436882

  11. Nonsymmetric Gravity Theories: Inconsistencies and a Cure

    E-print Network

    T. Damour; S. Deser; J. McCarthy

    1992-07-22

    Motivated by the apparent dependence of string $\\sigma$--models on the sum of spacetime metric and antisymmetric tensor fields, we reconsider gravity theories constructed from a nonsymmetric metric. We first show that all such "geometrical" theories homogeneous in second derivatives violate standard physical requirements: ghost-freedom, absence of algebraic inconsistencies or continuity of degree-of-freedom content. This no-go result applies in particular to the old unified theory of Einstein and its recent avatars. However, we find that the addition of nonderivative, ``cosmological'' terms formally restores consistency by giving a mass to the antisymmetric tensor field, thereby transmuting it into a fifth-force-like massive vector but with novel possible matter couplings. The resulting macroscopic models also exhibit ``van der Waals''-type gravitational effects, and may provide useful phenomenological foils to general relativity.

  12. 48 CFR 335.071 - Special determinations and findings affecting research and development contracting.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...determinations and findings affecting research and development contracting. 335.071...CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 335.071...and findings affecting research and development contracting. OPDIV...

  13. 48 CFR 335.071 - Special determinations and findings affecting research and development contracting.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...determinations and findings affecting research and development contracting. 335.071...CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 335.071...and findings affecting research and development contracting. OPDIV...

  14. Columbia University Medical Center researchers find that a new computational approach finds gene that drives aggressive brain cancer

    Cancer.gov

    Columbia University Medical Center researchers have combined existing computational tools with a new algorithm called DIGGIT, which 'walks' backward from the master regulators to find the genetic events that drive brain cancer.

  15. Detecting Digital Image Forgeries by Measuring Inconsistencies of Blocking Artifact

    Microsoft Academic Search

    Shuiming Ye; Qibin Sun; Ee-chien Chang

    2007-01-01

    Digital images can be forged easily with today's widely available image processing software. In this paper, we describe a passive approach to detect digital forgeries by checking inconsistencies of blocking artifact. Given a digital image, we find that the blocking artifacts introduced during JPEG compression could be used as a \\

  16. 1998 National Gun Policy Survey of the National Opinion Research Center: Research Findings

    NSDL National Science Digital Library

    Smith, Tom W.

    The National Opinion Research Center (NORC) at the University of Chicago in collaboration with the Johns Hopkins Center for Gun Policy and Research in 1999 released a final report based on the research findings of a national survey on gun policies. The 64-page study reports on topics such as the regulation of firearms, gun ownership and use, knowledge and attitudes toward guns, gun violence, and safety issues. The report includes thirteen statistical tables and concludes that the American public strongly supports "legislation to regulate firearms, make guns safer, and reduce the accessibility of firearms to criminals and children."

  17. Finding the ‘action’ in feminist participatory action research

    Microsoft Academic Search

    Colleen Reid; Allison Tom; Wendy Frisby

    2006-01-01

    Although feminist researchers have increasingly called for participatory and action-oriented research, there have been few analyses of the diverse actions that can occur. We theorized the actions considered and implemented in a feminist participatory action research project (FPAR). For three years we collaborated intensively with a group of diverse women on low income who were involved in a FPAR project

  18. 42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...Contest ORI Findings of Research Misconduct and HHS Administrative Actions General Information...contest ORI findings of research misconduct and HHS administrative actions, including any... (2) Accept or challenge each proposed HHS administrative action; (3)...

  19. USC researchers find new target for prostate cancer treatment

    Cancer.gov

    Scientists have found a promising new therapeutic target for prostate cancer. The findings offer evidence that a newly discovered member of a family of cell surface proteins called G-protein coupled receptors (GPCRs) promotes prostate cancer cell growth.

  20. Action Research Project: Prof 190-191 Finding Journal Articles

    E-print Network

    Abolmaesumi, Purang

    education databases. PPhhrraasseess "attention deficit hyperactivity disorder" BBoooolleeaann OOppeerraattoorrss:: OORR,, NNOOTT ((ddeeffaauulltt iiss AANNDD)) adhd OR "attention deficit" "differentiated by Queen's. use the Cited by feature to find related articles. PPhhrraasseess "attention deficit

  1. The Sponsored Research Lifecycle Part I: Finding a Sponsor

    E-print Network

    Bieber, Michael

    Elements ­ Research Experience vitalizes Instructional Activities ­ Research Accomplishment informs our Accomplishments Drive Public Recognition ­ Smart Gun ­ Mall & School Security ­ Stem Cell ­ Traffic Congestion of Education (ED) Department of Energy (DOE) Department of Health and Human Services (HHS) Department

  2. Seeking Renewal, Finding Community: Participatory Action Research in Teacher Education

    ERIC Educational Resources Information Center

    Draper, Roni Jo; Adair, Marta; Broomhead, Paul; Gray, Sharon; Grierson, Sirpa; Hendrickson, Scott; Jensen, Amy P.; Nokes, Jeffery D.; Shumway, Steven; Siebert, Daniel; Wright, Geoffrey

    2011-01-01

    This narrative study describes the experiences of a group of teacher educators as they worked together in a collaborative research activity investigating theories of literacy and the preparation of secondary teachers. The collaboration was organized around the precepts associated with participatory action research (PAR). After four years of…

  3. "Response to Comments": Finding the Narrative in Narrative Research

    ERIC Educational Resources Information Center

    Coulter, Cathy A.

    2009-01-01

    The author responds to comments by Barone (2009), Clandinin and Murphy (2009), and M. W. Smith (2009) on "The Construction Zone: Literary Elements in Narrative Research" (Coulter & M. L. Smith, 2009). She clarifies issues regarding point of view, authorial surplus, narrative coherence, and the relational qualities of narrative research. She…

  4. Researchers find nanodiamonds could improve effectiveness of breast cancer treatment

    Cancer.gov

    UCLA researchers and collaborators have developed a potentially more effective treatment for "triple-negative" breast cancer that uses nanoscale, diamond-like particles called nanodiamonds. Nanodiamonds are between 4 and 6 nanometers in diameter and are shaped like tiny soccer balls. Byproducts of conventional mining and refining operations, the particles can form clusters following drug binding and have the ability to precisely deliver cancer drugs to tumors, significantly improving the drugs' desired effect. UCLA is home to the Jonsson Comprehensive Cancer Center. The research team included contributors from the NanoCarbon Research Institute in Nagano, Japan and UC San Francisco, home of the Helen Diller Family Comprehensive Cancer Center.

  5. MD Anderson researchers find that yoga regulates stress hormones

    Cancer.gov

    Through a grant from the National Cancer Institute, researchers are now conducting a Phase III clinical trial in women with breast cancer to further determine the mechanisms of yoga that lead to improvement in physical functioning and quality of life.

  6. Roswell Park researchers find prognostic biomarker candidates for ovarian cancer

    Cancer.gov

    Cancer researchers at Roswell Park Cancer Institute have identified two independent classes of novel candidate prognostic markers for ovarian cancer, advancing efforts to develop targeted therapies for the disease.

  7. MIT researchers find new technology may enable earlier cancer diagnosis

    Cancer.gov

    A new technology developed at MIT may help to make biomarker detection much easier. The researchers, led by Sangeeta Bhatia, have developed nanoparticles that can home to a tumor and interact with cancer proteins to produce thousands of biomarkers.

  8. Research Finds Link Between Statin Use and Progressive Muscle Disease

    MedlinePLUS

    ... necrotizing myopathy, a progressive muscle wasting disease of unknown cause. Further investigation revealed that as many as three-fourths of these patients had previously used statins, leading the researchers to suspect from ...

  9. Find the Expert at the Agricultural Research Service

    NSDL National Science Digital Library

    The United States Department of Agriculture's Agricultural Research Service now offers a feature where users can directly ask questions of Agricultural experts. Searching is possible in three ways: Keyword, Broad Subject Area, or Research Area. Typical search results include lists of experts with contact addresses, including email. With subject areas ranging from Air Quality and Mitigation to Weeds, this service adds a nice notch in the measuring stick of improved scientific communication.

  10. Trade and Employment: Stylized Facts and Research Findings

    Microsoft Academic Search

    Bernard Hoekman; Alan L. Winters; L. Alan Winters

    2005-01-01

    The substantial literature investigating the links between trade, trade policy, and labour market outcomes has generated a number of stylized facts, but many open questions remain. A common finding is that much of the shorter-run impacts of trade and reforms involve reallocation of labour or wage impacts within sectors. Wage responses to trade and trade reforms are generally greater than

  11. SUMMARY OF RESEARCH FINDINGS IN OFF-FARM AGRICULTURAL OCCUPATIONS.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Center for Vocational and Technical Education.

    AS A RESULT OF TWO CONFERENCES HELD IN 1963-64, INTERVIEW-TYPE SURVEYS OF EMPLOYMENT NEEDS IN OFF-FARM AGRICULTURAL BUSINESSES WERE CONDUCTED IN 26 STATES IN 1964. THE ANALYSIS OF THE FINDINGS RESULTED IN THIS SYNTHESIS. INFORMATION IS GIVEN ON -- (1) NUMBERS OF PEOPLE EMPLOYED, (2) PRESENT NUMBER, ESTIMATED INCREASE, OCCUPATIONAL GROUP AND LEVEL…

  12. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...HHS action with settlement or finding of research misconduct. 93.411 Section 93...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.411...

  13. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...HHS action with settlement or finding of research misconduct. 93.411 Section 93...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.411...

  14. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...HHS action with settlement or finding of research misconduct. 93.411 Section 93...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.411...

  15. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 2012-10-01 false Findings of research misconduct and proposed administrative...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.404...

  16. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 2013-10-01 false Findings of research misconduct and proposed administrative...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.404...

  17. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...HHS action with settlement or finding of research misconduct. 93.411 Section 93...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.411...

  18. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 2010-10-01 false Findings of research misconduct and proposed administrative...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.404...

  19. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...HHS action with settlement or finding of research misconduct. 93.411 Section 93...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.411...

  20. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 2011-10-01 false Findings of research misconduct and proposed administrative...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.404...

  1. Incorporating Research Findings into Standards and Requirements for Space Medicine

    NASA Technical Reports Server (NTRS)

    Duncan, J. Michael

    2006-01-01

    The Vision for Exploration has been the catalyst for NASA to refocus its life sciences research. In the future, life sciences research funded by NASA will be focused on answering questions that directly impact setting physiological standards and developing effective countermeasures to the undesirable physiological and psychological effects of spaceflight for maintaining the health of the human system. This, in turn, will contribute to the success of exploration class missions. We will show how research will impact setting physiologic standards, such as exposure limits, outcome limits, and accepted performance ranges. We will give examples of how a physiologic standard can eventually be translated into an operational requirement, then a functional requirement, and eventually spaceflight hardware or procedures. This knowledge will be important to the space medicine community as well as to vehicle contractors who, for the first time, must now consider the human system in developing and constructing a vehicle that can achieve the goal of success.

  2. Finding Collaborators: Toward Interactive Discovery Tools for Research Network Systems

    PubMed Central

    Schleyer, Titus K; Becich, Michael J; Hochheiser, Harry

    2014-01-01

    Background Research networking systems hold great promise for helping biomedical scientists identify collaborators with the expertise needed to build interdisciplinary teams. Although efforts to date have focused primarily on collecting and aggregating information, less attention has been paid to the design of end-user tools for using these collections to identify collaborators. To be effective, collaborator search tools must provide researchers with easy access to information relevant to their collaboration needs. Objective The aim was to study user requirements and preferences for research networking system collaborator search tools and to design and evaluate a functional prototype. Methods Paper prototypes exploring possible interface designs were presented to 18 participants in semistructured interviews aimed at eliciting collaborator search needs. Interview data were coded and analyzed to identify recurrent themes and related software requirements. Analysis results and elements from paper prototypes were used to design a Web-based prototype using the D3 JavaScript library and VIVO data. Preliminary usability studies asked 20 participants to use the tool and to provide feedback through semistructured interviews and completion of the System Usability Scale (SUS). Results Initial interviews identified consensus regarding several novel requirements for collaborator search tools, including chronological display of publication and research funding information, the need for conjunctive keyword searches, and tools for tracking candidate collaborators. Participant responses were positive (SUS score: mean 76.4%, SD 13.9). Opportunities for improving the interface design were identified. Conclusions Interactive, timeline-based displays that support comparison of researcher productivity in funding and publication have the potential to effectively support searching for collaborators. Further refinement and longitudinal studies may be needed to better understand the implications of collaborator search tools for researcher workflows. PMID:25370463

  3. Most Colleges Chase Prestige on a Treadmill, Researchers Find

    ERIC Educational Resources Information Center

    Schmidt, Peter

    2008-01-01

    The pursuit of institutional prestige has done little to improve the reputations of most colleges, and it may be causing many of them to become less distinguishable from their competitors, new research shows. In one study presented at the annual conference of the Association for the Study of Higher Education, Kyle V. Sweitzer, a data-resource…

  4. Journals Find Many Images in Research Are Faked

    ERIC Educational Resources Information Center

    Young, Jeffrey R.

    2008-01-01

    Kristin Roovers was a postdoctoral fellow at the University of Pennsylvania with a bright career ahead of her--a trusted member of a research laboratory at the medical school studying the role of cell growth in diabetes. When an editor of "The Journal of Clinical Investigation" did a spot-check on one of her images for an article in 2005, Roovers'…

  5. Urban Delinquency and Substance Abuse. Initial Findings. Research Summary.

    ERIC Educational Resources Information Center

    Huizinga, David; Loeber, Rolf; Thornberry, Terence P.

    In collaborative efforts three research teams have investigated the problems of urban delinquency and substance abuse in longitudinal studies that have gone on since 1986. The Denver Youth Study is a longitudinal survey that involves annual interviews with probability samples of five different birth cohorts and their parents from areas of Denver…

  6. Employee Retention at ABC & Co. Northwest Arkansas. Research Findings.

    ERIC Educational Resources Information Center

    Hatcher, Timothy; And Others

    A 7-month research project was conducted by graduate students at a garment manufacturing plant in Fayetteville, Arkansas, to gain information about high employee turnover. Information also was gathered about the employment situation in northwest Arkansas in general, union-labor relationships, and how other companies handled turnover. Data were…

  7. Management Communication Ethics Research: Finding the Bull's-Eye.

    ERIC Educational Resources Information Center

    Reinsch, N. Lamar, Jr.

    1996-01-01

    Argues that scholars who wish to produce substantive research in management communication ethics would be helped by a clear vision of what the term designates. States that management communication ethics should designate concerns that lie at the intersection of management, communication, and ethics. Concludes that this approach could help to…

  8. Treatment of methamphetamine abuse: research findings and clinical directions

    Microsoft Academic Search

    Margaret Cretzmeyer; Mary Vaughan Sarrazin; Diane L. Huber; Robert I. Block; James A. Hall

    2003-01-01

    Over the past few years, methamphetamine has appeared in mass quantities, in part, because of the ease and cost efficiency of manufacturing. With this increase in availability, the use of methamphetamine has increased significantly. The purpose of this article is to describe the existing treatment options for methamphetamine abuse and provide recommendations for practitioners and researchers. Methamphetamine abuse adversely impacts

  9. Electrical Distribution. Project Report Phase I with Research Findings.

    ERIC Educational Resources Information Center

    Sappe', Hoyt; Kirkpatrick, Thomas

    This report provides results of Phase I of a project that researched the occupational area of electrical distribution, established appropriate committees, and conducted task verification. These results are intended to guide development of a program designed to train apprentice line workers. Section 1 contains general information: purpose of Phase…

  10. Pain, Nicotine, and Smoking: Research Findings and Mechanistic Considerations

    Microsoft Academic Search

    Joseph W. Ditre; Thomas H. Brandon; Emily L. Zale; Mary M. Meagher

    2011-01-01

    Tobacco addiction and chronic pain represent 2 highly prevalent and comorbid conditions that engender substantial burdens upon individuals and systems. Interrelations between pain and smoking have been of clinical and empirical interest for decades, and research in this area has increased dramatically over the past 5 years. We conceptualize the interaction of pain and smoking as a prototypical example of

  11. UT Southwestern researchers find new gene mutations for Wilms Tumor

    Cancer.gov

    Researchers at UT Southwestern Medical Center and the Gill Center for Cancer and Blood Disorders at Children’s Medical Center, Dallas, have made significant progress in defining new genetic causes of Wilms tumor, a type of kidney cancer found only in children.

  12. Emerging Answers: Research Findings on Programs To Reduce Teen Pregnancy.

    ERIC Educational Resources Information Center

    Kirby, Douglas

    This report summarizes three bodies of research on teenage pregnancy and programs to reduce the risk of teenage pregnancy. Studies included in this report were completed in 1980 or later, conducted in the United States or Canada, targeted adolescents, employed an experimental or quasi-experimental design, had a sample size of at least 100 in the…

  13. Reconciling (Seemingly) Discrepant Findings: Implications for Practice and Future Research

    ERIC Educational Resources Information Center

    Bowman, Nicholas A.; Herzog, Serge

    2011-01-01

    Decades of research in survey methodology and psychology have yielded important insights about how to create effective and valid survey instruments. As Porter (in press) has argued convincingly, college student surveys often fall well short of these standards by placing unrealistic demands on students' memory and by assuming that students readily…

  14. "UWA research will continue to find real solutions

    E-print Network

    Tobar, Michael

    capacity of the state, helping to keep Australian agriculture profitable and sustainable well of Agriculture Chair, and Director, The UWA Institute of Agriculture uwa is one of the top universities in the world for research and teaching in dryland agriculture and food production systems. the reputation

  15. Women Who Experienced Childhood Incest: Research Findings and Therapeutic Strategies.

    ERIC Educational Resources Information Center

    Courtois, Christine A.; Watts, Deborah

    Recognition of the gravity of the social problem of incest in the United States, coupled with increasing demands for psychological treatment and assistance from social service agencies by incest victims and their families, has demonstrated the need for controlled research in this area. Knowledge of the effects of incest is critical to the…

  16. FINDING THE BALANCE - QUALITY ASSURANCE REQUIREMENTS VS. RESEARCH NEEDS

    EPA Science Inventory

    Investigators often misapply quality assurance (QA) procedures and may consider QA as a hindrance to developing test plans for sampling and analysis. If used properly, however, QA is the driving force for collecting the right kind and proper amount of data. Researchers must use Q...

  17. FINDING THE BALANCE - QUALITY ASSURANCE REQUIREMENTS VS. RESEARCH NEEDS

    EPA Science Inventory

    Investigators often misapply quality assurance (QA) procedures and may consider QA as a hindrance to developing test plans for sampling and analysis. If used properly, however, QA is the driving force for collecting the right kind and proper amount of data. Researchers must...

  18. Vanderbilt researchers find that an enzyme affects tumor metastasis

    Cancer.gov

    Researchers have established a role for MMP2 in the development of lung metastases from primary breast cancer. Using mice without the Mmp2 gene, the team found that metastatic tumors in the lung proliferate less in the absence of fibroblast MMP2.

  19. Pain, Nicotine, and Smoking: Research Findings and Mechanistic Considerations

    ERIC Educational Resources Information Center

    Ditre, Joseph W.; Brandon, Thomas H.; Zale, Emily L.; Meagher, Mary M.

    2011-01-01

    Tobacco addiction and chronic pain represent 2 highly prevalent and comorbid conditions that engender substantial burdens upon individuals and systems. Interrelations between pain and smoking have been of clinical and empirical interest for decades, and research in this area has increased dramatically over the past 5 years. We conceptualize the…

  20. Bargaining and Faculty Reward Systems: Current Research Findings.

    ERIC Educational Resources Information Center

    Begin, James P.

    Empirical research literature on the relationship between faculty bargaining and faculty reward systems was reviewed. The emphasis was on five areas that may be affected by bargaining: the rationalization of institutional policies and practicies, particularly those related to personnel issues; a rationalization of grievance procedures, with a…

  1. Aligning Economic and Workforce Development Activities in Baltimore. Research Findings.

    ERIC Educational Resources Information Center

    Hicks, Lisa; Olins, Alexandra; Prince, Heath

    Recent efforts to build economic and work force development systems in seven leading cities were reviewed to inform similar efforts undertaken in Baltimore, Maryland. Research examining efforts to establish work force development systems in the following cities were analyzed: Austin, Texas; Berkeley, California; Boston, Massachusetts; Cleveland,…

  2. Research on Interest in Science: Theories, Methods, and Findings

    ERIC Educational Resources Information Center

    Krapp, Andreas; Prenzel, Manfred

    2011-01-01

    This article presents an overview of interest research and describes the theoretical and methodological background for the assessment of interest in science in large-scale assessments like the "Programme for International Student Assessment" (PISA). The paper starts with a short retrospective on the history of interest, bringing out theoretical…

  3. Finding a Place for Genomics in Health Disparities Research

    PubMed Central

    Fullerton, S.M.; Knerr, S.; Burke, W.

    2012-01-01

    The existence of pronounced differences in health outcomes between US populations is a problem of moral significance and public health urgency. Pursuing research on genetic contributors to such disparities, despite striking data on the fundamental role of social factors, has been controversial. Still, advances in genomic science are providing an understanding of disease biology at a level of precision not previously possible. The potential for genomic strategies to help in addressing population-level disparities therefore needs to be carefully evaluated. Using 3 examples from current research, we argue that the best way to maximize the benefits of population-based genomic investigations, and mitigate potential harms, is to direct research away from the identification of genetic causes of disparities and instead focus on applying genomic methodologies to the development of clinical and public health tools with the potential to ameliorate healthcare inequities, direct population-level health interventions or inform public policy. Such a transformation will require close collaboration between transdisciplinary teams and community members as well as a reorientation of current research objectives to better align genomic discovery efforts with public health priorities and well-recognized barriers to fair health care delivery. PMID:22488458

  4. Nyholm Lecture: Chemical Education Research: Facts, Findings, and Consequences.

    ERIC Educational Resources Information Center

    Johnstone, A. H.

    1983-01-01

    Discusses research indicating that presenting students with large amounts of information while their concepts are primitive prevents them from grouping/handling the very information they need to make concepts develop. Reducing the load or providing strategies to help students group/sequence the load are recommended. (JN)

  5. Current Mathematics Appears to Be Inconsistent

    E-print Network

    Guang-Liang Li; Victor O. K. Li

    2007-08-15

    We show that some mathematical results and their negations are both deducible. The derived contradictions indicate the inconsistency of current mathematics. This paper is an updated version of arXiv:math/0606635v3 with additional results and proofs.

  6. Clustering and Inconsistent Information: A Kernelization Approach

    E-print Network

    Cao, Yixin

    2012-07-16

    , the most widely studied formulations, correlation clustering and hierarchical clustering, are both NP-hard. In the graph representation of data, inconsistencies also frequently present themselves as cycles, also called deadlocks, and to break cycles...

  7. Inconsistency of Measure-Theoretic Probability

    E-print Network

    Guang-Liang Li; Victor O. K. Li

    2014-12-06

    We reveal a contradiction in measure-theoretic probability. The contradiction is an "equation" $1/2 = 0$ with its two sides representing probabilities. Unlike known paradoxes in mathematics, the revealed contradiction cannot be explained away and actually indicates that measure-theoretic probability is inconsistent. Appearing only in the theory, the contradiction does not exist in the physical world. So practical applications of measure-theoretic probability will not be affected by the inconsistency as long as "ideal events" in the theory (which will never occur physically) are not mistaken for real events in the physical world. Nevertheless, the inconsistency must be resolved. Constructive mathematics can avoid such inconsistency. There is no contradiction reported in constructive mathematics.

  8. Inconsistencies in the Formation of Cometary Matter

    NASA Astrophysics Data System (ADS)

    Keller, Horst Uwe; Huebner, Walter F.

    We will summarize the papers of the Joint Discussion 14 following the scheme of the introduction (W.F. Huebner and H.U. Keller) and highlight where inconsistencies have been solved confirmed or established by the presented contributions.

  9. Research Findings on Radiation Hormesis and Radon Therapy

    SciTech Connect

    Hattori, Sadao

    1999-06-06

    Radiation hormesis research in Japan to determine the validity of Luckey's claims has revealed information on the health effects of low-level radiation. The scientific data of animal tests we obtained and successful results actually brought by radon therapy on human patients show us a clearer understanding of the health effects of low-level radiation. We obtained many animal test results and epidemiological survey data through our research activities cooperating with more than ten universities in Japan, categorized as follows: 1. suppression of cancer by enhancement of the immune system based on gene activation; 2. rejuvenation and suppression of aging by increasing cell membrane permeability and enzyme syntheses; 3. adaptive response by activation of gene expression on DNA repair and cell apoptosis; 4. pain relief and stress moderation by hormone formation in the brain and central nervous system; 5. avoidance and therapy of obstinate diseases by enhancing damage control systems and form one formation.

  10. Migraine genetics: current findings and future lines of research.

    PubMed

    Persico, A M; Verdecchia, M; Pinzone, V; Guidetti, V

    2015-04-01

    In the last two decades, migraine research has greatly advanced our current knowledge of the genetic contributions and the pathophysiology of this common and debilitating disorder. Nonetheless, this knowledge still needs to grow further and to translate into more effective treatments. To date, several genes involved in syndromic and monogenic forms of migraine have been identified, allowing the generation of animal models which have significantly contributed to current knowledge of the mechanisms underlying these rare forms of migraine. Common forms of migraine are instead posing a greater challenge, as they may most often stem from complex interactions between multiple common genetic variants, with environmental triggers. This paper reviews our current understanding of migraine genetics, moving from syndromic and monogenic forms to oligogenic/polygenic migraines most recently addressed with some success through genome-wide association studies. Methodological issues in study design and future perspectives opened by biomarker research will also be briefly addressed. PMID:25501253

  11. Cancer researchers translate new laboratory findings to enhance melanoma treatment

    Cancer.gov

    Translational researchers from UCLA’s Jonsson Comprehensive Cancer Center (JCCC) have published results of two back-to-back studies in the journal Cancer Discovery that provide critical insights into two key areas of how tumors resist BRAF inhibitors: the key cell-signaling pathways BRAF-mutant melanoma cells use to learn how to become resistant to inhibitor drugs, and how the limited focus of BRAF inhibitors allows melanoma cells to evolve and develop drug resistance.

  12. Europlanet-RI/IDIS: Finding information for planetary research

    NASA Astrophysics Data System (ADS)

    Schmidt, Walter; Capria, Maria Teresa; Chanteur, Gerard

    The "Europlanet Research Infrastructure -Europlanet RI", supported by the European Com-mission's Framework Program 7, aims at integrating major parts of the distributed European Planetary Research infrastructure with as diverse components as space exploration, ground-based observations, laboratory experiments and numerical modelling teams. A central part of Europlanet RI is the "Integrated and Distributed Information Service" (IDIS), a network of data and information access facilities in Europe via which information relevant for planetary research can be easily found and retrieved. If a scientist is looking for possible collaborating colleagues or institutes in preparation of a new space project, for addresses of possible test facilities and their capabilities or for supporting data from other missions, laboratory measurements or modeling teams in analyzing own data, Europlanet/IDIS will give fast access to this information. While still under development, the infrastructure will develop during the following three years into a virtual observatory with the possibility of combining data from different science fields, observatories and missions. IDIS presents also an efficient way to publish the information about own activities or own laboratory's capabilities to possible future partners. For more information visit http://www.idis.europlanet-ri.eu/

  13. Gate valve and motor-operator research findings

    SciTech Connect

    Steele, R. Jr.; DeWall, K.G.; Watkins, J.C.; Russell, M.J.; Bramwell, D.

    1995-09-01

    This report provides an update on the valve research being sponsored by the US Nuclear Regulatory Commission (NRC) and conducted at the Idaho National Engineering Laboratory (INEL). The research addresses the need to provide assurance that motor-operated valves can perform their intended safety function, usually to open or close against specified (design basis) flow and pressure loads. This report describes several important developments: Two methods for estimating or bounding the design basis stem factor (in rising-stem valves), using data from tests less severe than design basis tests; a new correlation for evaluating the opening responses of gate valves and for predicting opening requirements; an extrapolation method that uses the results of a best effort flow test to estimate the design basis closing requirements of a gate valve that exhibits atypical responses (peak force occurs before flow isolation); and the extension of the original INEL closing correlation to include low- flow and low-pressure loads. The report also includes a general approach, presented in step-by-step format, for determining operating margins for rising-stem valves (gate valves and globe valves) as well as quarter-turn valves (ball valves and butterfly valves).

  14. Bioethanol from Lignocellulosic Biomass: Current Findings Determine Research Priorities

    PubMed Central

    Kang, Qian; Appels, Lise; Tan, Tianwei

    2014-01-01

    “Second generation” bioethanol, with lignocellulose material as feedstock, is a promising alternative for first generation bioethanol. This paper provides an overview of the current status and reveals the bottlenecks that hamper its implementation. The current literature specifies a conversion of biomass to bioethanol of 30 to ~50% only. Novel processes increase the conversion yield to about 92% of the theoretical yield. New combined processes reduce both the number of operational steps and the production of inhibitors. Recent advances in genetically engineered microorganisms are promising for higher alcohol tolerance and conversion efficiency. By combining advanced systems and by intensive additional research to eliminate current bottlenecks, second generation bioethanol could surpass the traditional first generation processes. PMID:25614881

  15. Discovery research: the scientific challenge of finding new antibiotics.

    PubMed

    Livermore, David M

    2011-09-01

    The dwindling supply of new antibiotics largely reflects regulatory and commercial challenges, but also a failure of discovery. In the 1990s the pharmaceutical industry abandoned its classical ways of seeking antibiotics and instead adopted a strategy that combined genomics with high-throughput screening of existing compound libraries. Too much emphasis was placed on identifying targets and molecules that bound to them, and too little emphasis was placed on the ability of these molecules to permeate bacteria, evade efflux and avoid mutational resistance; moreover, the compound libraries were systematically biased against antibiotics. The sorry result is that no antibiotic found by this strategy has yet entered clinical use and many major pharmaceutical companies have abandoned antibiotic discovery. Although a raft of start-up companies-variously financed by venture capital, charity or public money--are now finding new antibiotic compounds (some of them very promising in vitro or in early trials), their development through Phase III depends on financial commitments from large pharmaceutical companies, where the discouraging regulatory environment and the poor likely return on investment remain paramount issues. PMID:21700626

  16. Exploiting multimedia in reproductive science education: research findings.

    PubMed

    Senger, P L; Oki, A C; Trevisan, M S; McLean, D J

    2012-08-01

    Education in reproductive science is operating from an outdated paradigm of teaching and learning. Traditionally, reproductive education follows the pattern where students read a textbook, listen to instructor presentations, re-read the textbook and class notes and then complete a test. This paradigm is inefficient, costly and has not incorporated the potential that technology can offer with respect to increases in student learning. Further, teachers of reproductive science (and all of science for that matter) have little training in the use of documented methods of instructional design and cognitive psychology. Thus, most of us have learned to teach by repeating the approaches our mentors used (both good and bad). The technology now exists to explain complex topics using multimedia presentations in which digital animation and three-dimensional anatomical reconstructions greatly reduce time required for delivery while at the same time improving student understanding. With funding from the Small Business Innovation Research program through the U.S. Department of Education, we have developed and tested a multimedia approach to teaching complex concepts in reproductive physiology. The results of five separate experiments involving 1058 university students and 122 patients in an OB/GYN clinic indicate that students and patients learned as much or more in less time when viewing the multimedia presentations when compared to traditional teaching methodologies. PMID:22827348

  17. Researching the meaning of life: finding new sources of hope.

    PubMed

    Alon, Shirly

    2010-01-01

    The purpose of the paper is to discuss means of assisting terminally ill patients in seeking for sources of meaning and hope, alongside the acknowledgment that their lifespan is short.Psycho-spiritual aspects make a substantial component patients suffering from incurable illness have to deal with. Evaluating and mapping the causes and expressions of psychological--spiritual suffering may assist in tailoring appropriate strategies of distress relief. Therefore, interventions should be given in accordance with their specific focus of difficulties, as well as with wishes and needs. Appropriate interventions in palliative psychotherapeutic rapport are inspired by identifying new sources for meaning in current life (sometimes, aided by past experiences or future visions). Reinforcing sources for meaning may attempt in providing patients amongst:--equilibrium, between suffering and sorrow (which sometimes take over the patient's world), and on the other hand, new experiences, sense of satisfaction and fulfillment. Individual's acknowledgment that he is not completely withdrawn from the circle of life, and yet significance and fulfillment in life still exists. For a holistic meaning ? centered intervention it is advisable to simultaneously integrate two central axes: the existential analysis, inspired by concepts driven from Frenkl's Logotherapy, such as freedom of choice, personal responsibility, inner truth, hope and transcendentalism; the operative axis, enhancing meaning and hope by assisting patient's wishes come true. Patients are aware, many times, that those wishes may be their last one, therefore perceive their fulfillment as crucial for their sense of meaning. Moreover, those wishes may elevate patient and family's spirit and reduce risk of demoralization. Whereas existential--spiritual interventions are recommended to be given by qualified professional therapists, the operation of fulfilling wishes is feasible by everyone, from family members to multi-disciplinary staff. Case illustrations for meaning--centered interventions will be discussed in the course of the paper. Cultural and traditional differences within the Israeli society, expressed in themes of work with patients, will lead to the conclusion, that there are many creative ways for researching meaning of life and sources for hope. PMID:20590354

  18. Do HealthCare Decision Makers Find Economic Evaluations Useful? The Findings of Focus Group Research in UK Health Authorities

    Microsoft Academic Search

    Christiane Hoffmann; Boyka A. Stoykova; John Nixon; Julie M. Glanville; Kate Misso; Michael F. Drummond

    2002-01-01

    ObjectivesThe impact of economic evaluation studies on health-care decision makers has been shown to be rather limited. However, there is an increasing requirement for the cost-effectiveness of health-care interventions to be considered in formulating and implementing guidelines for clinical practice. This paper reports the findings of recent focus group research among UK health authorities, which examined the usefulness of published

  19. Social Science Research Findings and Educational Policy Dilemmas: Some Additional Distinctions.

    ERIC Educational Resources Information Center

    Miller, Steven I.; Fredericks, Marcel

    2000-01-01

    Explores the relationship of social science research to social policy making, stressing that social science models and research findings are largely irrelevant to the actual concerns of policymakers and noting the ways in which ideological factors mediate the process. (SLD)

  20. Incidental Computer Tomography Radiologic Findings through Research Participation in the North Texas Healthy Heart Study

    PubMed Central

    Espinoza, Anna; Malone, Kendra; Balyakina, Elizabeth; Fulda, Kimberly G.; Cardarelli, Roberto

    2014-01-01

    Background Although variation exists in the classification and practice of managing clinical findings in research, emerging views suggest that researchers bear some responsibility in the management of incidental findings. This study contributes to the documentation of the population characteristics and prevalence of medical findings incidental to research participation, specifically findings related to coronary calcium scores and computed tomography (CT) scans that investigated cardiovascular disparities in an asymptomatic population. Methods A total of 571 asymptomatic adult participants were recruited in the North Texas Healthy Heart Study. Participants completed a 16-slice CT scan of the heart and abdomen. Findings of radiology reports and 3 years of follow-up documentation were reviewed. Results A total of 246 clinically apparent findings were identified in 169 asymptomatic participants (32.9% of participants who completed a CT scan). Another 245 participants (48%) had findings of unknown significance, a total of 307 findings. At least 4 cases in this study led to a clinically significant intervention. Conclusion Although CT scans were completed for research purposes, study procedures resulted in the diagnosis and treatment of individuals who were previously asymptomatic. Potential clinical benefits in imaging research are moderated by considerations regarding possible harm and costs resulting from uncertain findings and the use of CT scans for nonclinical purposes. The continued development of protocols for the handling of incidental findings in research and the establishment of guidelines are needed to ensure that research procedures mirror the best interests of participants. PMID:24808109

  1. Heterogeneity in Choice Inconsistencies among the Elderly: Evidence from Prescription Drug Plan Choice

    E-print Network

    Abaluck, Jason

    This paper investigates the degree to which choice inconsistencies documented in the context of Medicare Part D plan choice vary across consumers and geographic regions. Our main finding is that there is surprisingly little ...

  2. Optimal identification using inconsistent modal data

    NASA Technical Reports Server (NTRS)

    Smith, Suzanne Weaver; Beattie, Christopher A.

    1991-01-01

    This work examines techniques under the general approach of optimal-update identification which produce optimally adjusted, or updated, property matrices (i.e., mass, stiffness and damping matrices) to more closely match the structure modal response. For practical applications, the techniques must perform when the modal response is inconsistent with other constraints on the desired model. An alternate view of the optimal-update problem is presented that leads to new techniques for addressing inconsistent data. Viewpoints used for previously published techniques are also examined to explore issues in optimal-update identification.

  3. Recent research related to juvenile sex offending: findings and directions for further research.

    PubMed

    Malin, H Martin; Saleh, Fabian M; Grudzinskas, Albert J

    2014-04-01

    Serious scholarly inquiry into juvenile sex offending represents a relatively new field, dating from the mid 1940s. During the next 4 decades, a mere handful of articles exploring aspects of juvenile sex offending were added to the available literature. By the 1980s, however, the literature began to increase rapidly, a trend that continues today. The purpose of this article is a focused review of the juvenile sex offender literature cited in PubMed over the last 5 years (2009-2013). The authors have chosen studies that will bring readers up to date on research they believe impacts our current understanding of best practices in the management of juvenile sex offending. For convenience, our review is organized into topical categories including research into characteristics and typologies of juvenile sex offenders, risk assessment and recidivism, assessment and treatment, the ongoing debate about mandatory registration of sex offenders as it applies to juveniles, and other thought provoking studies that do not fit neatly into the aforementioned categories. The studies included contain findings that both reinforce and challenge currently held notions about best practices concerning treatment and public policy, suggesting that our knowledge of the field continues to evolve in important ways. PMID:24562765

  4. Integrating findings of traditional medicine with modern pharmaceutical research: the potential role of linked open data

    Microsoft Academic Search

    Matthias Samwald; Michel Dumontier; Jun Zhao; Joanne S Luciano; Michael Scott Marshall; Kei Cheung

    2010-01-01

    One of the biggest obstacles to progress in modern pharmaceutical research is the difficulty of integrating all available research findings into effective therapies for humans. Studies of traditionally used pharmacologically active plants and other substances in traditional medicines may be valuable sources of previously unknown compounds with therapeutic actions. However, the integration of findings from traditional medicines can be fraught

  5. Humor Scholarship and TESOL: Applying Findings and Establishing a Research Agenda

    ERIC Educational Resources Information Center

    Bell, Nancy D.

    2011-01-01

    Research in the areas of second language (L2) pragmatics and of conversational humor has increased in recent decades, resulting in a strong base of knowledge from which applied linguists can draw information for teaching purposes and undertake future research. Yet, whereas empirical findings in L2 pragmatics are beginning to find their way into…

  6. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...2011-10-01 2011-10-01 false Final HHS action with no settlement or finding of...Research Misconduct Issues § 93.410 Final HHS action with no settlement or finding of research misconduct. When the final HHS action does not result in a...

  7. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...2014-10-01 2014-10-01 false Final HHS action with no settlement or finding of...Research Misconduct Issues § 93.410 Final HHS action with no settlement or finding of research misconduct. When the final HHS action does not result in a...

  8. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...2013-10-01 2013-10-01 false Final HHS action with no settlement or finding of...Research Misconduct Issues § 93.410 Final HHS action with no settlement or finding of research misconduct. When the final HHS action does not result in a...

  9. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...2012-10-01 2012-10-01 false Final HHS action with no settlement or finding of...Research Misconduct Issues § 93.410 Final HHS action with no settlement or finding of research misconduct. When the final HHS action does not result in a...

  10. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...2010-10-01 2010-10-01 false Final HHS action with no settlement or finding of...Research Misconduct Issues § 93.410 Final HHS action with no settlement or finding of research misconduct. When the final HHS action does not result in a...

  11. Fox Chase analysis finds more cutting-edge cancer research supported by industry

    Cancer.gov

    Nearly half of the research presented at ASCO’s annual meeting last year came from researchers with ties to companies, and the amount appears to be increasing every year, according to new findings from Fox Chase Cancer Center. The new findings will be presented this year at the 2012 American Society of Clinical Oncology Annual Meeting on Monday, June 4.

  12. Impact of problem finding on the quality of authentic open inquiry science research projects

    Microsoft Academic Search

    Frank Labanca

    2008-01-01

    Problem finding is a creative process whereby individuals develop original ideas for study. Secondary science students who successfully participate in authentic, novel, open inquiry studies must engage in problem finding to determine viable and suitable topics. This study examined problem finding strategies employed by students who successfully completed and presented the results of their open inquiry research at the 2007

  13. Practice-Based Research Networks, Part I: Clinical Laboratories to Generate and Translate Research Findings Into Effective Patient Care

    PubMed Central

    Sauers, Eric L.; McLeod, Tamara C. Valovich; Bay, R. Curtis

    2012-01-01

    Context To improve patient care, athletic training clinicians and researchers should work together to translate research findings into clinical practice. Problems with patient care observed in clinical practice should be translated into research frameworks, where they can be studied. Practice-based research networks (PBRNs) provide a compelling model for linking clinicians and researchers so they can conduct translational research to improve patient care. Objective To describe (1) the translational research model, (2) practice-based research as a mechanism for translating research findings into clinical practice, (3) the PBRN model and infrastructure, (4) the research potential using the PBRN model, and (5) protection of human participants in PBRN research. Description Translational research is the process of transforming research findings into health behavior that ultimately serves the public and attempts to bridge the gap between research and clinical practice. Practice-based research represents the final step in the translational research continuum and describes research conducted by providers in clinical practices. The PBRNs are characterized by an organizational framework that transcends a single site or study and serves as the clinical research “laboratory” for conducting comparative-effectiveness studies using patient-oriented measures. The PBRN approach to research has many benefits, including enhanced generalizability of results, pooling of resources, rapid patient recruitment, and collaborative opportunities. However, multisite research also brings challenges related to the protection of human participants and institutional review board oversight. Clinical and Research Advantages Athletic training studies frequently include relatively few participants and, consequently, are able to detect only large effects. The incidence of injury at a single site is sufficiently low that gathering enough data to adequately power a treatment study may take many years. Collaborative efforts across diverse clinical practice environments can yield larger patient samples to overcome the limitations inherent in single-site research efforts. PMID:23068593

  14. Applying Effective Instruction Research Findings in Teacher Education: Six Influencing Factors.

    ERIC Educational Resources Information Center

    Gee, Elsie W.

    This preliminary report provides an overview of the Applying Research to Teacher Education (ARTE) Research Utilization in Elementary Teacher Education (RUETE) study which began in 1982 and will continue through 1985. ARTE: RUETE explores specific processes for incorporating recent research findings of effective instruction into preservice…

  15. Enhancing the Interpretation of "Significant" Findings: The Role of Mixed Methods Research

    ERIC Educational Resources Information Center

    Onwuegbuzie, Anthony J.; Leech, Nancy L.

    2004-01-01

    The present essay outlines how mixed methods research can be used to enhance the interpretation of significant findings. First, we define what we mean by significance in educational evaluation research. With regard to quantitative-based research, we define the four types of significance: statistical significance, practical significance, clinical…

  16. Inconsistent Reports of Sexual Intercourse Among South African High School Students

    PubMed Central

    Palen, Lori-Ann; Smith, Edward A.; Caldwell, Linda L.; Flisher, Alan J.; Wegner, Lisa; Vergnani, Tania

    2008-01-01

    Purpose This study aims to describe patterns of inconsistent reports of sexual intercourse among a sample of South African adolescents. Methods Consistency of reported lifetime sexual intercourse was assessed using five semi-annual waves of data. Odds ratios related inconsistent reporting to demographic variables and potential indicators of general and risk-behavior-specific reliability problems. Results Of the sexually active participants in the sample, nearly 40% reported being a virgin after sexual activity had been reported at an earlier assessment. Inconsistent reporting could not be predicted by gender or race, nor by general indicators of poor reliability (inconsistent reporting of gender and birth year). However, those with inconsistent reports of sexual intercourse were more likely to be inconsistent reporters of substance use. Conclusions These results suggest that researchers need to undertake efforts to deal specifically with inconsistent risk behavior data. These may include the modification of data collection procedures and the use of statistical methodologies that can account for response inconsistencies. PMID:18295129

  17. Detection of Tampering Inconsistencies on Mobile Photos

    NASA Astrophysics Data System (ADS)

    Cao, Hong; Kot, Alex C.

    Fast proliferation of mobile cameras and the deteriorating trust on digital images have created needs in determining the integrity of photos captured by mobile devices. As tampering often creates some inconsistencies, we propose in this paper a novel framework to statistically detect the image tampering inconsistency using accurately detected demosaicing weights features. By first cropping four non-overlapping blocks, each from one of the four quadrants in the mobile photo, we extract a set of demosaicing weights features from each block based on a partial derivative correlation model. Through regularizing the eigenspectrum of the within-photo covariance matrix and performing eigenfeature transformation, we further derive a compact set of eigen demosaicing weights features, which are sensitive to image signal mixing from different photo sources. A metric is then proposed to quantify the inconsistency based on the eigen weights features among the blocks cropped from different regions of the mobile photo. Through comparison, we show our eigen weights features perform better than the eigen features extracted from several other conventional sets of statistical forensics features in detecting the presence of tampering. Experimentally, our method shows a good confidence in tampering detection especially when one of the four cropped blocks is from a different camera model or brand with different demosaicing process.

  18. Alcohol Use Disorders, Research Findings | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... of this page please turn Javascript on. Feature: Alcohol Use and Abuse Alcohol Use Research Findings Past Issues / Winter 2013 ... study supported by the NIH's National Institute on Alcohol Abuse and Alcoholism (NIAAA). The study is the first ...

  19. U of Pittsburgh researchers find stem cells in mice in the esophagus

    Cancer.gov

    In an animal study published online today in Cell Reports, researchers report findings from mice that could lead to new insights into the development and treatment of esophageal cancer and the precancerous condition known as Barrett's esophagus.

  20. U of Minnesota researchers find that microRNA is tied to colon cancer tumor growth

    Cancer.gov

    Researchers have identified microRNAs that may cause colon polyps from turning cancerous. The finding could help physicians provide more specialized, and earlier, treatment before colon cancer develops.

  1. Researcher Tales and Research Ethics: The Spaces in Which We Find Ourselves

    ERIC Educational Resources Information Center

    White, Julie; Fitzgerald, Tanya

    2010-01-01

    The tales we tell here focus on the ethical issues arising from our research practice with vulnerable young participants and those for whom research has been inextricably linked with European imperialism and colonialism. The importance of relational obligations, temporality and potential for a continuing narrative approach to ethical research

  2. Impact of problem finding on the quality of authentic open inquiry science research projects

    NASA Astrophysics Data System (ADS)

    Labanca, Frank

    2008-11-01

    Problem finding is a creative process whereby individuals develop original ideas for study. Secondary science students who successfully participate in authentic, novel, open inquiry studies must engage in problem finding to determine viable and suitable topics. This study examined problem finding strategies employed by students who successfully completed and presented the results of their open inquiry research at the 2007 Connecticut Science Fair and the 2007 International Science and Engineering Fair. A multicase qualitative study was framed through the lenses of creativity, inquiry strategies, and situated cognition learning theory. Data were triangulated by methods (interviews, document analysis, surveys) and sources (students, teachers, mentors, fair directors, documents). The data demonstrated that the quality of student projects was directly impacted by the quality of their problem finding. Effective problem finding was a result of students using resources from previous, specialized experiences. They had a positive self-concept and a temperament for both the creative and logical perspectives of science research. Successful problem finding was derived from an idiosyncratic, nonlinear, and flexible use and understanding of inquiry. Finally, problem finding was influenced and assisted by the community of practicing scientists, with whom the students had an exceptional ability to communicate effectively. As a result, there appears to be a juxtaposition of creative and logical/analytical thought for open inquiry that may not be present in other forms of inquiry. Instructional strategies are suggested for teachers of science research students to improve the quality of problem finding for their students and their subsequent research projects.

  3. School Effectiveness Research Findings in the Portuguese Speaking Countries: Brazil and Portugal

    ERIC Educational Resources Information Center

    Ferrão, Maria Eugénia

    2014-01-01

    This paper provides findings of research on school effectiveness and discusses implications for evaluation in Brazil and Portugal. Most findings reported over the last decade have been published in Brazilian or Portuguese refereed journals. Thus, a brief literature review of such studies enables that knowledge to reach international scholars and…

  4. Improving Student Achievement in Mathematics, Part 1: Research Findings. ERIC Digest.

    ERIC Educational Resources Information Center

    Grouws, Douglas A.; Cebulla, Kristin J.

    This digest summarizes research findings on best teacher practices in mathematics education. Among the findings are: students can learn both concepts and skills by solving problems; whole-class discussion following individual and group work improves student achievement; and using calculators in the learning of mathematics can result in increased…

  5. NIH Researchers Find Resveratrol Helps Protect Against Diabetes in Animal Study

    MedlinePLUS

    NIH researchers find resveratrol helps protect against diabetes in animal study August 8, 2013 Resveratrol, a compound in nuts, grapes, and wine, has ... of non-human primates, researchers have found that resveratrol counters some of the negative effects of a ...

  6. Disclosure of Incidental Findings From Next-Generation Sequencing in Pediatric Genomic Research

    PubMed Central

    Abdul-Karim, Ruqayyah; Berkman, Benjamin E.; Wendler, David; Rid, Annette; Khan, Javed; Badgett, Tom

    2013-01-01

    Next-generation sequencing technologies will likely be used with increasing frequency in pediatric research. One consequence will be the increased identification of individual genomic research findings that are incidental to the aims of the research. Although researchers and ethicists have raised theoretical concerns about incidental findings in the context of genetic research, next-generation sequencing will make this once largely hypothetical concern an increasing reality. Most commentators have begun to accept the notion that there is some duty to disclose individual genetic research results to research subjects; however, the scope of that duty remains unclear. These issues are especially complicated in the pediatric setting, where subjects cannot currently but typically will eventually be able to make their own medical decisions at the age of adulthood. This article discusses the management of incidental findings in the context of pediatric genomic research. We provide an overview of the current literature and propose a framework to manage incidental findings in this unique context, based on what we believe is a limited responsibility to disclose. We hope this will be a useful source of guidance for investigators, institutional review boards, and bioethicists that anticipates the complicated ethical issues raised by advances in genomic technology. PMID:23400601

  7. Young, Drunk, Dangerous and Driving: Underage Drinking and Driving Research Findings.

    ERIC Educational Resources Information Center

    Little, Robert; Clontz, Kenneth

    1994-01-01

    Summarizes major, recent research findings concerning illegal alcohol use and intoxicated driving among American youth. Examines what research revealed about the nature of underage drinking and driving; what health, social, and legal ramifications are associated with drinking and driving; and what characteristics and behavioral patterns are found…

  8. Rotation Checklist (from the IG handbook) You can find information on genetics faculty research

    E-print Network

    Mayfield, John

    Rotation Checklist (from the IG handbook) You can find information on genetics faculty research ______________________________________ Research talks given by faculty various faculty seminar series through IG and through the departments. Once. The IG program is willing to assist you in this as well. This will allow you to do at least 3 full- term

  9. THE TEN MOST SIGNIFICANT EDUCATIONAL RESEARCH FINDINGS IN THE PAST TEN YEARS.

    ERIC Educational Resources Information Center

    DAVIES, DANIEL R.; GRIFFITHS, DANIEL E.

    TO ASCERTAIN THE SIGNIFICANCE OF RESEARCH IN EDUCATION, THREE QUESTIONS MAY BE ASKED--(1) TO WHAT EXTENT HAS THE BEHAVIOR OF INDIVIDUALS IN EDUCATION BEEN CHANGED. (2) HOW MANY ARTICLES HAVE BEEN WRITTEN AS A RESULT OF THE FINDINGS. (3) TO WHAT EXTENT DO EDUCATORS TALK ABOUT OR USE THE CONCEPTS GENERATED BY THE RESEARCH IN DISCUSSING THEIR OWN…

  10. Technology to Support Writing by Students with Learning and Academic Disabilities: Recent Research Trends and Findings

    ERIC Educational Resources Information Center

    Peterson-Karlan, George R.

    2011-01-01

    The trends and findings from a descriptive analysis of 25 years of research studies examining the effectiveness of technology to support the compositional writing of students with learning and academic disabilities are presented. A corpus of 85 applied research studies of writing technology effectiveness was identified from among 249 items in the…

  11. User Research Findings for Purdue University Library Website Redesign Major themes from undergraduate focus group

    E-print Network

    Zhang, Tao

    ): Undergraduates: 1. Need a website design that shows school pride. 2. Will simply use article and catalog searchUser Research Findings for Purdue University Library Website Redesign Major themes from undergraduate focus group: 1. If undergraduates are assigned a research topic, they go to the library website

  12. Affirming our commitment to research: the Medical Library Association's research policy statement: the process and findings*

    PubMed Central

    Grefsheim, Suzanne F.; Rankin, Jocelyn A.; Perry, Gerald J.; McKibbon, K. Ann

    2008-01-01

    Purpose: Building on its 1995 research policy statement, the Medical Library Association (MLA) has issued a new research policy, The Research Imperative. This paper shares the background research that informed the new policy. Methods: Semi-structured interviews were conducted with fifty-one key informants representing various library types, functions, geographic locations, ages, and ethnicities. The grounded theory approach was used to analyze the resulting textual database. Additionally, to gather input from the membership as a whole, two open forums were held at MLA annual meetings. Results: Key informant data indicated that the policy should provide roles for MLA in leadership, advocacy, collaboration, services, education, publishing, and development of a research agenda. Evidence-based library and information practice was emphasized. Six themes emerged to center the new policy: creation of a research culture, challenges, domains of research, research skills set, roles of stakeholders, and measurement of progress. Conclusion: Reflecting the interests and beliefs of the membership, The Research Imperative challenges MLA members to build a supportive culture that values and contributes to a research base that is recognized as an essential tool for future practice. PMID:18379666

  13. Models of consent to return of incidental findings in genomic research.

    PubMed

    Appelbaum, Paul S; Parens, Erik; Waldman, Cameron R; Klitzman, Robert; Fyer, Abby; Martinez, Josue; Price, W Nicholson; Chung, Wendy K

    2014-01-01

    Genomic research-including whole genome sequencing and whole exome sequencing-has a growing presence in contemporary biomedical investigation. The capacity of sequencing techniques to generate results that go beyond the primary aims of the research-historically referred to as "incidental findings"-has generated considerable discussion as to how this information should be handled-that is, whether incidental results should be returned, and if so, which ones.Federal regulations governing most human subjects research in the United States require the disclosure of "the procedures to be followed" in the research as part of the informed consent process. It seems reasonable to assume-and indeed, many commentators have concluded-that genomic investigators will be expected to inform participants about, among other procedures, the prospect that incidental findings will become available and the mechanisms for dealing with them. Investigators, most of whom will not have dealt with these issues before, will face considerable challenges in framing meaningful disclosures for research participants.To help in this task, we undertook to identify the elements that should be included in the informed consent process related to incidental findings. We did this by surveying a large number of genomic researchers (n = 241) and by conducting in-depth interviews with a smaller number of researchers (n = 28) and genomic research participants (n = 20). Based on these findings, it seems clear to us that routine approaches to informed consent are not likely to be effective in genomic research in which the prospect of incidental findings exists. Ensuring that participants' decisions are informed and meaningful will require innovative approaches to dealing with the consent issue. We have identified four prototypical models of a consent process for return of incidental findings. PMID:24919982

  14. FRESHWATER FINDINGS, 1979-1982: RESEARCH PUBLICATIONS OF THE ENVIRONMENTAL RESEARCH LABORATORY, DULUTH, MINNESOTA

    EPA Science Inventory

    This report contains citations of publications for the years 1979-1982 on research conducted or supported by the Environmental Research Laboratory-Duluth. All published material has been organized into two major categories: (1) Journal Articles, Book Chapters, Proceedings, etc., ...

  15. From research to control: Translating research findings into health policies, operational guidelines and health products.

    PubMed

    Kilama, Wen

    2009-11-01

    Although Africa's health research capacity is still weak, African R&D institutions are contributing immensely to the development of health policies, guidelines and products essential for diagnosis, treatment, prevention and control of Africa's leading health problems. In order to increase Africa's contributions, all health research stakeholders should participate in setting health research priorities and agenda, followed by establishing health research networks and consortia, holistic capacity strengthening, and gathering of baseline data. The evaluation of candidate tools, and the research preceding it, must abide by international scientific and ethical standards, and must involve institutional and national regulatory authorities. The funding of product development and product availability in Africa benefits from national governments, bilateral, multilateral, and philanthropic agencies. When a trial is over poses many social and ethical issues, and not infrequently existing guidelines may not be adequate. Mechanisms for making products available in resource constrained countries are presented, as are problems relating to manufacturing, markets and procurement. So are obligations to trial and research communities. The paper concludes by outlining the obligations of each stakeholder, in order to make research products readily available in resource constrained settings. PMID:19686696

  16. Freshwater findings, 1979-1982: research publications of the Environmental Research Laboratory, Duluth, Minnesota

    SciTech Connect

    Highland, T.; Curtis, C.

    1983-10-01

    This report contains citations of publications for the years 1979-1982 on research conducted or supported by the Environmental Research Laboratory-Duluth. All published material has been organized into two major categories: (1) Journal Articles, Book Chapters, Proceedings, etc., and (2) EPA Research Reports. The report is organized by year with all journal articles, book chapters, proceedings, etc., for a given year appearing before the EPA research reports for the same year; within each category publications are listed alphabetically by author. Authors of the publications listed include ERL-Duluth laboratory staff members and scientists at universities, in industry, and at other facilities who received research funding under the auspices of the Environmental Research Laboratory-Duluth. Limited quantities of reprints are available for those articles identified by ERL-Duluth reprint number in parentheses following the citation. These can be obtained by writing to: Librarian, ERL-Duluth, U.S. EPA, 6201 Congdon Boulevard, Duluth, MN 55804. EPA research reports can be obtained by writing to: National Technical Information Service, 5285 Port Royal Road, Springfield, VA 22151. All other articles are not available from ERL-Duluth or NTIS, but can be found in most major libraries.

  17. Disseminating research findings: what should researchers do? A systematic scoping review of conceptual frameworks

    PubMed Central

    2010-01-01

    Background Addressing deficiencies in the dissemination and transfer of research-based knowledge into routine clinical practice is high on the policy agenda both in the UK and internationally. However, there is lack of clarity between funding agencies as to what represents dissemination. Moreover, the expectations and guidance provided to researchers vary from one agency to another. Against this background, we performed a systematic scoping to identify and describe any conceptual/organising frameworks that could be used by researchers to guide their dissemination activity. Methods We searched twelve electronic databases (including MEDLINE, EMBASE, CINAHL, and PsycINFO), the reference lists of included studies and of individual funding agency websites to identify potential studies for inclusion. To be included, papers had to present an explicit framework or plan either designed for use by researchers or that could be used to guide dissemination activity. Papers which mentioned dissemination (but did not provide any detail) in the context of a wider knowledge translation framework, were excluded. References were screened independently by at least two reviewers; disagreements were resolved by discussion. For each included paper, the source, the date of publication, a description of the main elements of the framework, and whether there was any implicit/explicit reference to theory were extracted. A narrative synthesis was undertaken. Results Thirty-three frameworks met our inclusion criteria, 20 of which were designed to be used by researchers to guide their dissemination activities. Twenty-eight included frameworks were underpinned at least in part by one or more of three different theoretical approaches, namely persuasive communication, diffusion of innovations theory, and social marketing. Conclusions There are currently a number of theoretically-informed frameworks available to researchers that can be used to help guide their dissemination planning and activity. Given the current emphasis on enhancing the uptake of knowledge about the effects of interventions into routine practice, funders could consider encouraging researchers to adopt a theoretically-informed approach to their research dissemination. PMID:21092164

  18. A Systematic Review on the Designs of Clinical Technology: Findings and Recommendations for Future Research

    PubMed Central

    PhD, Greg Alexander; Staggers, Nancy

    2010-01-01

    Human factors (HF) studies are increasingly important as technology infuses into clinical settings. No nursing research reviews exist in this area. The authors conducted a systematic review on designs of clinical technology, 34 articles with 50 studies met inclusion criteria. Findings were classified into three categories based on HF research goals. The majority of studies evaluated effectiveness of clinical design; efficiency was fewest. Current research ranges across many interface types examined with no apparent pattern or obvious rationale. Future research should expand types, settings, participants; integrate displays; and expand outcome variables. PMID:19707093

  19. Divergent hemispheric reasoning strategies: reducing uncertainty versus resolving inconsistency

    PubMed Central

    Marinsek, Nicole; Turner, Benjamin O.; Gazzaniga, Michael; Miller, Michael B.

    2014-01-01

    Converging lines of evidence from diverse research domains suggest that the left and right hemispheres play distinct, yet complementary, roles in inferential reasoning. Here, we review research on split-brain patients, brain-damaged patients, delusional patients, and healthy individuals that suggests that the left hemisphere tends to create explanations, make inferences, and bridge gaps in information, while the right hemisphere tends to detect conflict, update beliefs, support mental set-shifts, and monitor and inhibit behavior. Based on this evidence, we propose that the left hemisphere specializes in creating hypotheses and representing causality, while the right hemisphere specializes in evaluating hypotheses, and rejecting those that are implausible or inconsistent with other evidence. In sum, we suggest that, in the domain of inferential reasoning, the left hemisphere strives to reduce uncertainty while the right hemisphere strives to resolve inconsistency. The hemispheres’ divergent inferential reasoning strategies may contribute to flexible, complex reasoning in the healthy brain, and disruption in these systems may explain reasoning deficits in the unhealthy brain. PMID:25374526

  20. Research education: findings of a study of teaching-learning research using multiple analytical perspectives.

    PubMed

    Vandermause, Roxanne; Barbosa-Leiker, Celestina; Fritz, Roschelle

    2014-12-01

    This multimethod, qualitative study provides results for educators of nursing doctoral students to consider. Combining the expertise of an empirical analytical researcher (who uses statistical methods) and an interpretive phenomenological researcher (who uses hermeneutic methods), a course was designed that would place doctoral students in the midst of multiparadigmatic discussions while learning fundamental research methods. Field notes and iterative analytical discussions led to patterns and themes that highlight the value of this innovative pedagogical application. Using content analysis and interpretive phenomenological approaches, together with one of the students, data were analyzed from field notes recorded in real time over the period the course was offered. This article describes the course and the study analysis, and offers the pedagogical experience as transformative. A link to a sample syllabus is included in the article. The results encourage nurse educators of doctoral nursing students to focus educational practice on multiple methodological perspectives. PMID:25406843

  1. February 28, 2001 1 Managing Process Inconsistency using Viewpoints

    E-print Network

    Sommerville, Ian

    February 28, 2001 1 Managing Process Inconsistency using Viewpoints Managing Process Inconsistency on a software system specification to be managed, we have developed the notion of process viewpoints improvement #12;February 28, 2001 2 Managing Process Inconsistency using Viewpoints 1. Introduction Over

  2. Scalable and Systematic Detection of Buggy Inconsistencies in Source Code

    E-print Network

    Su, Zhendong

    inconsistently. This paper presents DejaVu, a highly scalable system for detecting these general syntactic inconsistency bugs. DejaVu operates in two phases. Given a target code base, a parallel inconsistent clone+ million line pre-production commercial code base, DejaVu executed in under five hours and produced

  3. Major Research Findings of The University of Kansas Institute for Research in Learning Disabilities

    E-print Network

    Clark, Frances L.

    1981-10-01

    -Vocabul ary_and Spelling t. and Ross Tests of Higher Co-9JJ) t-ive·· Prqce~ses-Rel_~va_n.t and Irrelevant Information).- -- - ·--- · ·- -·- - · ---- · · · · -- · MAJOR FINDINGS : 1. 2. 3. 4. 5. 6. Some behavioral ch'aracteri sti cs differentiate LD... the result of environmental influences. 4. Learning disabilities are unique to childhood rather than a handicap that persists into adolescence and adulthood. 5. Learning disabled individuals are as handicapped in adjusting to community living...

  4. Translating research findings to promote peace: moving from "field to forum" with verbatim theatre.

    PubMed

    Liehr, Patricia; Morris, Kate; Leavitt, Mary Ann; Takahashi, Ryutaro

    2013-01-01

    Peace, both personal and global, resides in understanding. Verbatim theatre is introduced as a vehicle for translating research findings to promote understanding and thereby, promote health. By shifting our translation lens from "bench to bedside" to "field to forum," new opportunities arise for moving nursing research-findings to an engaged audience. Stories from Pearl Harbor and Hiroshima survivors were woven into the verbatim performance, With Their Voices Raised. Analysis of audience members' reflections after the performance suggests that verbatim theatre created a connection based in openness, engagement, and trust that informed understanding and raised awareness about peace processes. PMID:23907299

  5. Nutrition and Growth: Recent Research Findings and Research Priorities. Matrix No. 3.

    ERIC Educational Resources Information Center

    Graham, George G.

    Recent research indicates that low income adults and infants in the United States are more likely to be overweight than undernourished. Very possibly, the assumptions upon which food supplement programs are based are ill-founded. While many of the currently operating broadly conceived supplemental food programs achieve desirable collateral…

  6. Research to practice: Using research findings to inform the first-year engineering experience

    Microsoft Academic Search

    H. Watson; O. Pierrakos; T. Newbold

    2010-01-01

    Meaningful experiences in the first year of an engineering curriculum are known to motivate students and help student retention in engineering. On-going research in the School of Engineering is aimed at understanding the formation of an engineering identity in students, as well as classifying and assessing problem-based learning practices embodied throughout the curriculum. Investigations were conducted with the inaugural freshman

  7. Social science research related to wildfire management: an overview of recent findings and future research needs

    E-print Network

    dimensions of wildland fire covering diverse topics including: attitudes towards pre-fire mitigation, social fire-mitigation efforts before a fire. Over time, social science research has continued to examine of natural-resource management, the approach to managing wildland fires has evolved over time as scientific

  8. Evaluating the Impact of Professional Development on Teaching Practice: Research Findings and Future Research Directions

    ERIC Educational Resources Information Center

    Doherty, Iain

    2011-01-01

    Continuing professional development for teaching is important for institutional renewal, teacher development and student learning improvement. However, our longitudinal research into provision of continuing professional development has shown that the majority of educators who attend professional development workshops do not put what they have…

  9. Research on Self-Determination in Physical Education: Key Findings and Proposals for Future Research

    ERIC Educational Resources Information Center

    Van den Berghe, Lynn; Vansteenkiste, Maarten; Cardon, Greet; Kirk, David; Haerens, Leen

    2014-01-01

    Background: During the last 30 years, several theories of motivation have generated insights into the motives underlying learners' behavior in physical education. Self-determination theory (SDT), a general theory on social development and motivation, has enjoyed increasing popularity in physical education research during the past decade. SDT…

  10. Findings of innovation research applied to quality management principles for health care.

    PubMed

    Gustafson, D H; Hundt, A S

    1995-01-01

    We asked health care professionals to identify and prioritize barriers to implementing TQM in their organizations. Lack of evidence of TQM success was a commonly listed barrier. In response, we drew from research in the innovation literature that identifies factors that distinguish successful from failed efforts to innovate and improve. Applied to TQM principles, innovation findings overwhelmingly support customer and quality mindedness. To a lesser degree other principles are upheld, suggesting future research in the area. PMID:7607882

  11. Myalgic encephalomyelitis: a review with emphasis on key findings in biomedical research

    PubMed Central

    Hooper, M

    2007-01-01

    This review examines research findings in patients with myalgic encephalomyelitis in light of the current debate about this chronic multiple?symptom, multiorgan, multisystem illness and the conflicting views in medicine. These issues cannot be separated from the political opinions and assertions that conflict with science and medicine, and will be part of this review as they have enormous consequences for scientific and medical research, patients, clinicians, carers and policy makers. PMID:16935967

  12. Positive Effects of Utilizing Relationships Between Inconsistencies for more Effective Inconsistency

    E-print Network

    Egyed, Alexander

    Inconsistency Resolution (NIER Track) Alexander Nöhrer Johannes Kepler University Linz, Austria alexander.noehrer@jku.at Alexander Reder Johannes Kepler University Linz, Austria alexander.reder@jku.at Alexander Egyed Johannes Kepler University Linz, Austria alexander.egyed@jku.at ABSTRACT State-of-the-art modeling tools can help

  13. Application of Research Findings and Summary of Research Needs: Bud Britton Memorial Symposium on Metabolic Disorders of Feedlot Cattle1

    Microsoft Academic Search

    M. L. Galyean; K. S. Eng

    Updated research findings with acido- sis, feedlot bloat, liver abscesses, and sudden death syndromes were presented at the Bud Britton Memorial Symposium on Metabolic Disorders of Feed- lot Cattle. Possible industry applications include the need to establish guidelines for use of clostridial vaccines in feedlot cattle, further assessment of the relationship between acidosis and polioen- cephalomalacia, examination of the effects

  14. RESEARCH ARTICLE Open Access Childhood adversity as a risk for cancer: findings

    E-print Network

    Paris-Sud XI, Université de

    ,6]. In humans, early life exposure to Adverse Childhood Experiences (ACE), like trauma, abuse or maltreatmentRESEARCH ARTICLE Open Access Childhood adversity as a risk for cancer: findings from the 1958,2,3 and Cyrille Delpierre1,2 Abstract Background: To analyse whether Adverse Childhood Experiences (ACE

  15. Trust in Leadership: Meta-Analytic Findings and Implications for Research and Practice

    Microsoft Academic Search

    Donald L. FERRIN; K. T. Dirks

    2002-01-01

    In this study, the authors examined the findings and implications of the research on trust in leadership that has been conducted during the past 4 decades. First, the study provides estimates of the primary relationships between trust in leadership and key outcomes, antecedents, and correlates (k = 106). Second, the study explores how specifying the construct with alternative leadership referents

  16. Student Engagement and Student Outcomes: Key Findings from "CCSSE" Validation Research

    ERIC Educational Resources Information Center

    McClenney, Kay; Marti, C. Nathan; Adkins, Courtney

    2012-01-01

    The findings from 20 years of research on undergraduate education have been unequivocal: The more actively engaged students are--with college faculty and staff, with other students, and with the subject matter they study--the more likely they are to learn, to stick with their studies, and to attain their academic goals. The existing literature,…

  17. Genetically Informative Research on Adolescent Substance Use: Methods, Findings, and Challenges

    ERIC Educational Resources Information Center

    Lynskey, Michael T.; Agrawal, Arpana; Heath, Andrew C.

    2010-01-01

    Objective: To provide an overview of the genetic epidemiology of substance use and misuse in adolescents. Method: A selective review of genetically informative research strategies, their limitations, and key findings examining issues related to the heritability of substance use and substance use disorders in children and adolescents is presented.…

  18. Revisiting the Research Findings on Heritage Language Learning: Three Interpretive Frames.

    ERIC Educational Resources Information Center

    Danesi, Marcel

    1991-01-01

    Proposes that heritage language education research findings in Canada fall within three interpretive frames, involving (1) interdependence, which posits that languages complement each other; (2) narrativity, which suggests that there is a narrative structure to the developing mind; and (3) cognitive enhancement, which posits that language and…

  19. Research on the caretaking of children of incarcerated parents: Findings and their service delivery implications

    Microsoft Academic Search

    Thomas E. Hanlon; Steven B. Carswell; Marc Rose

    2007-01-01

    This paper reviews research findings on caretaking-related problems associated with the absence of parents from the home following incarceration. It focuses on the impact of incarceration on the welfare and adjustment of urban African American children and on the assumption of caretaking responsibilities by other caretakers, principally maternal grandmothers. Noting the complex situational difficulties involved and the potential burdens associated

  20. Can Research Findings Help School Systems Obtain the Most Bang from the Construction Bucks?

    ERIC Educational Resources Information Center

    Earthman, Glen I.; Lemasters, Linda K.

    Research on educational facilities is important to help industry and school districts make decisions on funding and maintaining good educational environments for their students. This paper presents findings from three syntheses of 232 studies on educational facilities and funding decisions, followed by discussions of practical solutions designed…

  1. Managing innovation and change processes: Findings from the Minnesota innovation research program

    Microsoft Academic Search

    Roger Schroeder; Andrew Van de Ven; Gary Scudder; Douglas Polley

    1986-01-01

    This article describes how innovations develop over time based on findings emerging from seven innovations included in the Minnesota Innovation Research Program. These observations are very different from typical models in the literature of the innovation process. The actual process is fluid, and includes an initial shock to propel the innovation into being, proliferation of the original idea, setbacks and

  2. Translating Research Findings to PTSD Prevention: Results of a Randomized–Controlled Pilot Study

    Microsoft Academic Search

    Yori Gidron; Reuven Gal; Sara Freedman; Irit Twiser; Ari Lauden; Yoram Snir; Jonathan Benjamin

    2001-01-01

    Based on therapeutic studies revealing positive prognostic factors and on research findings revealing how trauma is processed, we developed the memory structuring intervention (MSI) in attempt to prevent posttraumatic stress disorder (PTSD). The MSI attempts to shift processing of traumatic memory from uncontrollable somatosensory and affective processes to more controlled linguistic and cognitive processes by providing patients organization, labeling, and

  3. Public Understanding of Cognitive Neuroscience Research Findings: Trying to Peer beyond Enchanted Glass

    ERIC Educational Resources Information Center

    Grotzer, Tina A.

    2011-01-01

    This article considers the appeal of cognitive neuroscience research to the general public within the context of the deep puzzles involved in using our minds to understand how our minds work. It offers a few promising examples of findings that illuminate the ways of the mind and reveal these workings to be counter-intuitive with our subjective…

  4. Indiana U researchers find that blood test could help to diagnose pancreatic cancer

    Cancer.gov

    Indiana U researchers find that a blood test could help to diagnose pancreatic cancer. The disease is difficult to diagnose in early stages because the pancreas is hidden behind other organs such as the stomach, small intestine, liver, gallbladder, spleen and bile ducts.

  5. Research-Doctorate Programs in the Biomedical Sciences: Selected Findings from the NRC Assessment

    ERIC Educational Resources Information Center

    Lorden, Joan F., Ed.; Kuh, Charlotte V., Ed.; Voytuk, James A., Ed.

    2011-01-01

    "Research Doctorate Programs in the Biomedical Sciences: Selected Findings from the NRC Assessment" examines data on the biomedical sciences programs to gather additional insight about the talent, training environment, outcomes, diversity, and international participation in the biomedical sciences workforce. This report supports an earlier…

  6. Undersea researchers find little oil spill damage so far By KRISTA KLAUS | News Channel 8

    E-print Network

    Belogay, Eugene A.

    Undersea researchers find little oil spill damage so far By KRISTA KLAUS | News Channel 8 Published of the Gulf of Mexico in the wake of BP's massive Deepwater Horizon oil spill made a brief stopover today life before and after the largest oil spill in the history of the Gulf of Mexico. #12;"This

  7. Violence in the night-time economy: key findings from the research

    Microsoft Academic Search

    Andrea Finney

    Violent behaviour in and around pubs and clubs on weekend nights presents a significant public health, criminal justice and urban management problem. Many people are injured in such violence, a significant minority of whom are permanently disfigured. In many of these incidents, alcohol has been consumed. The key findings from published UK and international research on violence in the night-time

  8. Finding links to cancer Masonic Cancer Center researchers work to identify carcinogens

    E-print Network

    Minnesota, University of

    Finding links to cancer Masonic Cancer Center researchers work to identify carcinogens in the world around us--as well as ways to avoid them When scientists talk about "environmental" causes of cancer are linked to as many as two out of every three cancers diagnosed. DeAnn Lazovich, Ph.D., M.P.H., is one

  9. Summary of Research Findings on the Military General Educational Development Program. Final Report.

    ERIC Educational Resources Information Center

    Waller, Earl A.

    This report summarizes and integrates the finding of research studies dealing with the military General Educational Development (GED) program. The major areas covered include (1) the field conduct of the GED program, (2) characteristics of GED program participants, (3) a comparison of the utility of the GED certificate with that of the high school…

  10. The Effective Elementary School Principal: Theoretical Bases, Research Findings and Practical Implications.

    ERIC Educational Resources Information Center

    Burnett, I. Emett, Jr.; Pankake, Anita M.

    Although much of the current school reform movement relies on the basic assumption of effective elementary school administration, insufficient effort has been made to synthesize key concepts found in organizational theory and management studies with relevant effective schools research findings. This paper attempts such a synthesis to help develop…

  11. [What happens to children and adolescents with mental disorders? Findings from long-term outcome research].

    PubMed

    Steinhausen, Hans-Christoph

    2013-11-01

    Research on the long-term outcome of mental disorders originating in childhood and adolescence is an important part of developmental psychopathology. After a brief sketch of relevant terms of outcome research, the first part of this review reports findings based on heterotypic cohort studies. The major second part of this review presents findings based on long-term outcome studies dealing with homotypic diagnostic groups. In particular, the review focuses on the course and prognosis of ADHD, anxiety disorders, depression, conduct disorders, eating disorders, autism spectrum disorders, schizophrenia, and selective mutism. Findings mainly support the vulnerability hypothesis regarding mental disorders with early manifestation in childhood and adolescence as frequent precursors of mental disorders in adulthood. The discussion focuses on the impact of early manifesting disorders in the frame of general mental morbidity and of the effect of interventions, which is not yet sufficiently discernible. PMID:24240498

  12. New research findings on emotionally focused therapy: introduction to special section.

    PubMed

    Johnson, Susan M; Wittenborn, Andrea K

    2012-06-01

    This article introduces the special section "New Research Findings on Emotionally Focused Therapy." Emotionally focused couple therapy researchers have a strong tradition of outcome and process research and this special section presents new findings from three recent studies. The first study furthers the goal of determining the kinds of clients for which EFT is effective (Denton, Wittenborn, & Golden, this issue) and the next two studies (Furrow, Edwards, Choi, & Bradley, this issue; Wittenborn, this issue) focus on the person of the therapist and provide some implications for EFT intervention and training. Together, these three studies provide valuable lessons on how to deepen our knowledge of the application of EFT for different populations and therapists. PMID:22765321

  13. HESS Opinions "On forecast (in)consistency in a hydro-meteorological chain: curse or blessing?"

    NASA Astrophysics Data System (ADS)

    Pappenberger, F.; Cloke, H. L.; Persson, A.; Demeritt, D.

    2011-01-01

    Flood forecasting increasingly relies on Numerical Weather Prediction (NWP) forecasts to achieve longer lead times (see Cloke et al., 2009; Cloke and Pappenberger, 2009). One of the key difficulties that is emerging in constructing a decision framework for these flood forecasts is when consecutive forecasts are different, leading to different conclusions regarding the issuing of forecasts, and hence inconsistent. In this opinion paper we explore some of the issues surrounding such forecast inconsistency (also known as "jumpiness", "turning points", "continuity" or number of "swings"; Zoster et al., 2009; Mills and Pepper, 1999; Lashley et al., 2008). We begin by defining what forecast inconsistency is; why forecasts might be inconsistent; how we should analyse it; what we should do about it; how we should communicate it and whether it is a totally undesirable property. The property of consistency is increasingly emerging as a hot topic in many forecasting environments (for a limited discussion on NWP inconsistency see Persson, 2011). However, in this opinion paper we restrict the discussion to a hydro-meteorological forecasting chain in which river discharge forecasts are produced using inputs from NWP. In this area of research (in)consistency is receiving recent interest and application (see e.g., Bartholmes et al., 2008; Pappenberger et al., 2011).

  14. Addressing inconsistencies in black carbon literature

    NASA Astrophysics Data System (ADS)

    Shonkoff, S. B.; Chafe, Z.; Smith, K. R.

    2010-12-01

    The literature describing black carbon (BC) emissions, and their effect on Earth’s climate, is growing rapidly. Unfortunately, inconsistencies in definitions; data collection and characterization; system boundaries; and time horizons have led to confusion about the relative importance of BC compared to other climate-active pollutant (CAPs). We discuss three sources of confusion: 1) Currently available BC inventories are not directly comparable to those used by the IPCC to track the greenhouse gases (GHGs) considered in the Kyoto Protocol (CO2, CH4, N2O). In particular, BC inventories often include all emissions: natural and anthropogenic in origin, controllable and non-controllable. IPCC inventories include only anthropogenic emissions. This BC accounting is appropriate for atmospheric science deliberations, but risks being interpreted as an overstatement against official Kyoto GHG inventories in a policy or control context. The IPCC convention of using 1750 as the starting year for emission inventories further complicates matters: significant BC emissions were emitted previous to that date by both human and natural sources. Though none of the pre-1750 BC emissions remain in the atmosphere today, their legacy presents challenges in assigning historical responsibility for associated global warming among sectors and regional populations. 2) Inconsistencies exist in the specific emissions sources considered in atmospheric models used to predict net BC forcing often lead to widely varying climate forcing estimates. For example, while some analyses consider only fossil fuel 1, others include both open biomass burning and fossil fuel combustion 2, and yet others include sources beyond biomass and fossil fuel burning 3. 3) Inconsistencies exist in how analyses incorporate the relationship between BC emissions and the associated cooling aerosols and processes, such as organic carbon (OC), and aerosol indirect effects (AIE). Unlike Kyoto GHGs, BC is rarely emitted in pure form and always with significant emissions of OC aerosols. The OC/BC ratio, however, is quite variable by emission source and often poorly characterized both in its current state and under intervention scenarios. In contrast, sulfur emissions, which become cooling sulfate (SO4) aerosols, are less intrinsically linked to other emissions, i.e., they can be controlled separately. Comparisons often ignore the substantial differences in uncertainties across the CAPs. These sources of confusion operate in a landscape of shifting scientific understanding of the RF from BC, including the work by Ramanathan and Carmichael (2008) indicating a BC RF that is roughly double the IPCC AR4 1 value for BC without organic carbon (OC). Doubling the impact of BC has a major impact on the relative importance of sectors for interventions. An approach is to consider post-AR4 estimates for BC, methane, etc. as part of sensitivity analyses, until a full new assessment becomes available. 1. Solomon S, Qin D, Manning M, et al. Working Group I Report: "The Physical Science Basis". Cambridge, UK and New York, NY, US: IPCC; 2007. 2. Jacobson MZ. Strong radiative heating due to the mixing state of black carbon in atmospheric aerosols. Nature 2001;409:695-7. 3. Ramanathan V, Carmichael G. Global and regional climate changes due to black carbon. Nature Geoscience 2008;1:221-7.

  15. U-M researchers find driver of breast cancer stem cell metastasis

    Cancer.gov

    Researchers at the University of Michigan Comprehensive Cancer Center have found that a cancer gene linked to aggressive spread of the disease promotes breast cancer stem cells. The finding implies a new way to target the behavior of these lethal cells. The finding involves the cancer gene RhoC, which has previously been shown to promote metastasis of many types of cancer. RhoC levels increase as breast cancer progresses and high levels of RhoC are associated with worse patient survival.

  16. A dynamical inconsistency of Horava gravity

    SciTech Connect

    Henneaux, Marc [Universite Libre de Bruxelles and International Solvay Institutes, ULB-Campus Plaine CP231, 1050 Brussels (Belgium); Centro de Estudios Cientificos (CECS), Casilla 1469, Valdivia (Chile); Kleinschmidt, Axel; Lucena Gomez, Gustavo [Universite Libre de Bruxelles and International Solvay Institutes, ULB-Campus Plaine CP231, 1050 Brussels (Belgium)

    2010-03-15

    The dynamical consistency of the nonprojectable version of Horava gravity is investigated by focusing on the asymptotically flat case. It is argued that for generic solutions of the constraint equations the lapse must vanish asymptotically. We then consider particular values of the coupling constants for which the equations are tractable and in that case we prove that the lapse must vanish everywhere--and not only at infinity. Put differently, the Hamiltonian constraints are generically all second-class. We then argue that the same feature holds for generic values of the couplings, thus revealing a physical inconsistency of the theory. In order to cure this pathology, one might want to introduce further constraints but the resulting theory would then lose much of the appeal of the original proposal by Horava. We also show that there is no contradiction with the time-reparametrization invariance of the action, as this invariance is shown to be a so-called 'trivial gauge symmetry' in Horava gravity, hence with no associated first-class constraints.

  17. What clinicians want: Findings from a psychotherapy practice research network survey.

    PubMed

    Tasca, Giorgio A; Sylvestre, John; Balfour, Louise; Chyurlia, Livia; Evans, Jane; Fortin-Langelier, Benjamin; Francis, Kylie; Gandhi, Jasmine; Huehn, Linda; Hunsley, John; Joyce, Anthony S; Kinley, Jackie; Koszycki, Diana; Leszcz, Molyn; Lybanon-Daigle, Vanessa; Mercer, Deanna; Ogrodniczuk, John S; Presniak, Michelle; Ravitz, Paula; Ritchie, Kerri; Talbot, Jeanne; Wilson, Brian

    2015-03-01

    Practice research networks may be one way of advancing knowledge translation and exchange (KTE) in psychotherapy. In this study, we document this process by first asking clinicians what they want from psychotherapy research. Eighty-two psychotherapists in 10 focus groups identified and discussed psychotherapy research topics relevant to their practices. An analysis of these discussions led to the development of 41 survey items. In an online survey, 1,019 participants, mostly practicing clinicians, rated the importance to their clinical work of these 41 psychotherapy research topics. Ratings were reduced using a principal components analysis in which 9 psychotherapy research themes emerged, accounting for 60.66% of the variance. Two postsurvey focus groups of clinicians (N = 22) aided in interpreting the findings. The ranking of research themes from most to least important were-Therapeutic Relationship/Mechanisms of Change, Therapist Factors, Training and Professional Development, Client Factors, Barriers and Stigma, Technology and Adjunctive Interventions, Progress Monitoring, Matching Clients to Therapist or Therapy, and Treatment Manuals. Few differences were noted in rankings based on participant age or primary therapeutic orientation. Postsurvey focus group participants were not surprised by the top-rated items, as they were considered most proximal and relevant to therapists and their work with clients during therapy sessions. Lower ranked items may be perceived as externally imposed agendas on the therapist and therapy. We discuss practice research networks as a means of creating new collaborations consistent with KTE goals. Findings of this study can help to direct practitioner-researcher collaborations. (PsycINFO Database Record (c) 2015 APA, all rights reserved). PMID:25528356

  18. Integrating findings of traditional medicine with modern pharmaceutical research: the potential role of linked open data

    PubMed Central

    2010-01-01

    One of the biggest obstacles to progress in modern pharmaceutical research is the difficulty of integrating all available research findings into effective therapies for humans. Studies of traditionally used pharmacologically active plants and other substances in traditional medicines may be valuable sources of previously unknown compounds with therapeutic actions. However, the integration of findings from traditional medicines can be fraught with difficulties and misunderstandings. This article proposes an approach to use linked open data and Semantic Web technologies to address the heterogeneous data integration problem. The approach is based on our initial experiences with implementing an integrated web of data for a selected use-case, i.e., the identification of plant species used in Chinese medicine that indicate potential antidepressant activities. PMID:21167050

  19. Repackaging prostate cancer support group research findings: an e-KT case study.

    PubMed

    Oliffe, John L; Han, Christina S; Lohan, Maria; Bottorff, Joan L

    2015-01-01

    In the context of psychosocial oncology research, disseminating study findings to a range of knowledge "end-users" can advance the well-being of diverse patient subgroups and their families. This article details how findings drawn from a study of prostate cancer support groups were repackaged in a knowledge translation website--www.prostatecancerhelpyourself.ubc.ca--using Web 2.0 features. Detailed are five lessons learned from developing the website: the importance of pitching a winning but feasible idea, keeping a focus on interactivity and minimizing text, negotiating with the supplier, building in formal pretests or a pilot test with end-users, and completing formative evaluations based on data collected through Google™ and YouTube™ Analytics. The details are shared to guide the e-knowledge translation efforts of other psychosocial oncology researchers and clinicians. PMID:24713522

  20. UNC researchers find new genetic target for a different kind of cancer drug

    Cancer.gov

    Researchers from the UNC School of Medicine have discovered that the protein RBM4, a molecule crucial to the process of gene splicing, is drastically decreased in multiple forms of human cancer, including lung and breast cancers. The finding, published in the journal Cancer Cell, offers a new route toward therapies that can thwart the altered genetic pathways that allow cancer cells to proliferate and spread.

  1. UCSD researchers find enzyme accelerates malignant stem cell cloning in chronic myeloid leukemia

    Cancer.gov

    An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia (CML), a cancer of the blood and marrow that experts say is increasing in prevalence. The findings are published in the Dec. 24 online early edition of the Proceedings of the National Academy of Sciences (PNAS). UCSD is home to the Moores Comprehensive Cancer Center.

  2. Return of individual research results and incidental findings in the clinical trials cooperative group setting.

    PubMed

    Ferriere, Michael; Van Ness, Brian

    2012-04-01

    The National Cancer Institute (NCI)-funded cooperative group cancer clinical trial system develops experimental therapies and often collects samples from patients for correlative research. The cooperative group bank (CGB) system maintains biobanks with a current policy not to return research results to individuals. An online survey was created, and 10 directors of CGBs completed the surveys asking about understanding and attitudes in changing policies to consider return of incidental findings (IFs) and individual research results (IRRs) of health significance. The potential impact of the 10 consensus recommendations of Wolf et al. presented in this issue are examined. Reidentification of samples is often not problematic; however, changes to the current banking and clinical trial systems would require significant effort to fulfill an obligation of recontact of subjects. Additional resources, as well as a national advisory board would be required to standardize implementation. PMID:22382800

  3. Inconsistencies and open questions regarding low-dose health effects of ionizing radiation.

    PubMed Central

    Nussbaum, R H; Köhnlein, W

    1994-01-01

    The effects on human health of exposures to ionizing radiation at low doses have long been the subject of dispute. In this paper we focus on open questions regarding the health effects of low-dose exposures that require further investigations. Seemingly contradictory findings of radiation health effects have been reported for the same exposed populations, or inconsistent estimates of radiation risks were found when different populations and exposure conditions were compared. Such discrepancies may be indicative of differences in sensitivities among the applied methods of epidemiological analysis or indicative of significant discrepancies in health consequences after comparable total exposures of different populations under varying conditions. We focus first on inconsistencies and contradictions in presentations of the state of knowledge by different authoritative experts. We then review studies that found positive associations between exposure and risks in dose ranges where traditional notions (generalized primarily from high-dose studies of A-bomb survivors or exposed animals) would have predicted negligible effects. One persistent notion in many reviews of low-dose effects is the hypothesis of reduced biological effectiveness of fractionated low-dose exposures, compared to that of the same acute dose. This assumption is not supported by data on human populations. From studies of populations that live in contaminated areas, more and more evidence is accumulating on unusual rates of various diseases other than radiation-induced malignancies, health effects that are suspected to be associated with relatively low levels of internal exposures originating from radioactive fallout. Such effects include congenital defects, neonatal mortality, stillbirths, and possibly genetically transmitted disease. A range of open questions challenges scientists to test imaginative hypotheses about induction of disease by radiation with novel research strategies. Images Figure 1. PMID:7895705

  4. Research on the Caretaking of Children of Incarcerated Parents: Findings and Their Service Delivery Implications.

    PubMed

    Hanlon, Thomas E; Carswell, Steven B; Rose, Marc

    2007-03-01

    This paper reviews research findings on caretaking-related problems associated with the absence of parents from the home following incarceration. It focuses on the impact of incarceration on the welfare and adjustment of urban African American children and on the assumption of caretaking responsibilities by other caretakers, principally maternal grandmothers. Noting the complex situational difficulties involved and the potential burdens associated with surrogate parenting in general, and with this population in particular, the service-provider implications of this parenting arrangement are considered in this review. Findings indicate that problems associated with incarceration of parents tend to be intergenerational and vary considerably in complexity and severity. To the extent that they impact the children involved, these issues should be addressed in coordinated service delivery focusing on prevention. PMID:18311320

  5. Research on the Caretaking of Children of Incarcerated Parents: Findings and Their Service Delivery Implications

    PubMed Central

    Hanlon, Thomas E.; Carswell, Steven B.; Rose, Marc

    2007-01-01

    This paper reviews research findings on caretaking-related problems associated with the absence of parents from the home following incarceration. It focuses on the impact of incarceration on the welfare and adjustment of urban African American children and on the assumption of caretaking responsibilities by other caretakers, principally maternal grandmothers. Noting the complex situational difficulties involved and the potential burdens associated with surrogate parenting in general, and with this population in particular, the service-provider implications of this parenting arrangement are considered in this review. Findings indicate that problems associated with incarceration of parents tend to be intergenerational and vary considerably in complexity and severity. To the extent that they impact the children involved, these issues should be addressed in coordinated service delivery focusing on prevention. PMID:18311320

  6. Inconsistency of classical logic in type theory Herman Geuvers

    E-print Network

    Geuvers, Herman

    present the Lego code of the Hurkens inconsistency proof in #U - . 2 Hurkens' proof of the inconsistency seen the proof of Hurkens, Randy Pollack and the author wanted to formalize the proof in Lego, also and the Lego code is presented below. Of course, this proof development cannot be done in standard Lego (or Coq

  7. Inconsistency Management and Prioritized Syntax-Based Entailment

    Microsoft Academic Search

    Salem Benferhat; Claudette Cayrol; Didier Dubois; Jérôme Lang; Henri Prade

    1993-01-01

    The idea of ordering plays a basic role in commonsense reasoning for addressing three inter­ related tasks: inconsistency handling, belief revi­ sion and plausible inference. We study the behavior of non-monotonic inferences induced by various methods for priority-based handling of inconsistent sets of classical formulas. One of them is based on a lexicographic ordering of maximal consistent subsets, and refines

  8. Differentiating Normal Variability from Inconsistency in Children's Speech: Normative Data

    ERIC Educational Resources Information Center

    Holm, Alison; Crosbie, Sharon; Dodd, Barbara

    2007-01-01

    Background: In young, typically developing children, some word production variability is expected, but highly inconsistent speech is considered a clinical marker for disorder. Speech-language pathologists need to identify variability versus inconsistency, yet these terms are not clearly differentiated. Not only is it important to identify…

  9. SUPPORTING TRACEABILITY AND INCONSISTENCY MANAGEMENT BETWEEN SOFTWARE ARTEFACTS

    E-print Network

    Grundy, John

    a conceptual architecture and prototype for supporting traceability and inconsistency management between: traceability, inconsistency management, requirements encoding, use case models, test plans 1 Introduction As software systems continue to grow larger and more complex the software developer is faced with managing

  10. DETECTING DIGITAL IMAGE FORGERIES BY MEASURING INCONSISTENCIES OF BLOCKING ARTIFACT

    E-print Network

    Sun, Qibin

    in the blocking artifact inconsistencies in the whole images, such as block mismatching and object retouchingDETECTING DIGITAL IMAGE FORGERIES BY MEASURING INCONSISTENCIES OF BLOCKING ARTIFACT Shuiming Ye 1.a-star.edu.sg, changec@comp.nus.edu.sg ABSTRACT Digital images can be forged easily with today's widely available image

  11. Using Semantic Distances for Reasoning with Inconsistent Ontologies

    Microsoft Academic Search

    Zhisheng Huang; Frank Van Harmelen

    2008-01-01

    Re-using and combining multiple ontologies on the Web is bound to lead to inconsistencies between the combined vocabularies. Even many of the ontologies that are in use today turn out to be incon- sistent once some of their implicit knowledge is made explicit. However, robust and ecient methods to deal with inconsistencies are lacking from current Semantic Web reasoning systems,

  12. Feminism, status inconsistency, and women's intimate partner victimization in heterosexual relationships.

    PubMed

    Franklin, Cortney A; Menaker, Tasha A

    2014-07-01

    This study used a random community sample of 303 women in romantic relationships to investigate the role of educational and employment status inconsistency and patriarchal family ideology as risk factors for intimate partner violence (IPV) victimization, while considering demographic factors and relationship context variables. Sequential multivariate logistic regression models demonstrated a decrease in the odds of IPV victimization for Hispanic women and women who were older as compared with their counterparts. In addition, increased relationship distress, family-of-origin violence, and employment status inconsistency significantly increased the odds of IPV. Clinical intervention strategies and future research directions are discussed. PMID:25031363

  13. Do people value being fair or not being unfair? Behavior inconsistent with \\

    Microsoft Academic Search

    Jason Dana; Roberto A. Weber

    2003-01-01

    Abstract Subjects in economic experiments regularly appear to reveal concern for the payoffs of others. Current economic,models incorporate this behavioral regularity as a stable preference for others’ welfare or for equal or fair outcomes. The present research demonstrates allocation choices among,selves and others that are inconsistent with such a stable preference. Our experiments reveal that eliminating the direct link between

  14. When Learners Surpass Their Models: The Acquisition of American Sign Language from Inconsistent Input

    ERIC Educational Resources Information Center

    Singleton, Jenny L.; Newport, Elissa L.

    2004-01-01

    The present study examines the impact of highly inconsistent input on language acquisition. The American deaf community provides a unique opportunity to observe children exposed to nonnative language models as their only linguistic input. This research is a detailed case study of one child acquiring his native language in such circumstances. It…

  15. Stanford researchers find antibody hinders growth of Gleevec-resistant gastrointestinal tumors in lab tests

    Cancer.gov

    An antibody that binds to a molecule on the surface of a rare but deadly tumor of the gastrointestinal tract inhibits the growth of the cancer cells in mice, according to researchers at the Stanford University School of Medicine (home of the Stanford Cancer Institute). The effect remains even when the cancer cells have become resistant to other treatments, and the findings may one day provide a glimmer of hope for people with the cancer, known as gastrointestinal stromal tumor, or GIST. The scientists hope to move into human clinical trials of the antibody within two years.

  16. Dana-Farber researchers find new culprit in castration-resistant prostate cancer

    Cancer.gov

    Scientists at Dana-Farber Cancer Institute have discovered a molecular switch that enables advanced prostate cancers to spread without stimulation by male hormones, which normally are needed to spur the cancer's growth. They say the finding could lead to a new treatment for prostate cancers that are no longer controlled by hormone-blocking drugs. The researchers report in the Dec. 14 issue of Science that the molecular switch occurs in a protein, EZH2, which is increased in these tumors, termed castration-resistant prostate cancers (CRPC).

  17. Detecting and Characterizing Semantic Inconsistencies in Ported Code

    NASA Technical Reports Server (NTRS)

    Ray, Baishakhi; Kim, Miryung; Person,Suzette; Rungta, Neha

    2013-01-01

    Adding similar features and bug fixes often requires porting program patches from reference implementations and adapting them to target implementations. Porting errors may result from faulty adaptations or inconsistent updates. This paper investigates (1) the types of porting errors found in practice, and (2) how to detect and characterize potential porting errors. Analyzing version histories, we define five categories of porting errors, including incorrect control- and data-flow, code redundancy, inconsistent identifier renamings, etc. Leveraging this categorization, we design a static control- and data-dependence analysis technique, SPA, to detect and characterize porting inconsistencies. Our evaluation on code from four open-source projects shows that SPA can detect porting inconsistencies with 65% to 73% precision and 90% recall, and identify inconsistency types with 58% to 63% precision and 92% to 100% recall. In a comparison with two existing error detection tools, SPA improves precision by 14 to 17 percentage points.

  18. Detecting and Characterizing Semantic Inconsistencies in Ported Code

    NASA Technical Reports Server (NTRS)

    Ray, Baishakhi; Kim, Miryung; Person, Suzette J.; Rungta, Neha

    2013-01-01

    Adding similar features and bug fixes often requires porting program patches from reference implementations and adapting them to target implementations. Porting errors may result from faulty adaptations or inconsistent updates. This paper investigates (I) the types of porting errors found in practice, and (2) how to detect and characterize potential porting errors. Analyzing version histories, we define five categories of porting errors, including incorrect control- and data-flow, code redundancy, inconsistent identifier renamings, etc. Leveraging this categorization, we design a static control- and data-dependence analysis technique, SPA, to detect and characterize porting inconsistencies. Our evaluation on code from four open-source projects shows thai SPA can dell-oct porting inconsistencies with 65% to 73% precision and 90% recall, and identify inconsistency types with 58% to 63% precision and 92% to 100% recall. In a comparison with two existing error detection tools, SPA improves precision by 14 to 17 percentage points

  19. Recent findings on biosolids cake odor reduction--results of WERF phase 3 biosolids odor research.

    PubMed

    Erdal, Zeynep K; Forbes, Robert H; Witherspoon, Jay; Adams, Greg; Hargreaves, Ron; Morton, Rob; Novak, John; Higgins, Matthew

    2008-11-01

    The Water Environment Research Foundation (WERF) has sponsored three phases of a long-term project entitled "Identifying and Controlling Odors in the Municipal Wastewater Environment." The current (third) phase focuses on reduction of odors from dewatered biosolids cakes, and is entitled "Biosolids Processing Modifications for Cake Odor Reduction." This phase encompasses nine research agenda items developed from the results of the prior phase of research (Phase 2), which was completed in December 2003 as WERF Report No. 00-HHE-5T and was entitled "Impacts of In-Plant Parameters on Biosolids Odor Quality." The current phase (Phase 3) was a 2.5-year project, the first half of which was dedicated to testing several of the more promising hypotheses from Phase 2 in the laboratory to help determine the cause-effect relationships of odor generation from biosolids, and to develop odor reduction techniques. It is important to note that this research project covers the reduction or prevention of odorous emissions from dewatered biosolids cake, not odor control by means of containment or adsorption or absorption of malodorous emissions. In the remainder of the Phase 3 project, promising laboratory findings are being applied to biosolids handling processes at one or more wastewater treatment plants (WWTPs), with the goal of achieving significant cake odor reduction in a realistic, full-scale setting. The Phase 3 laboratory results were used to identify the relative effectiveness of methods for reducing biosolids cake odors, using techniques and measurements of biosolids cake odor production potential that have been developed by the WERF Project Team. Plans to demonstrate the most promising research findings at full-scale biosolids digestion and dewatering facilities constitute the final, fourth phase of the project. Contacts have been made with wastewater treatment facilities that have an interest or need to reduce their biosolids cake odors. The main goal of the next phase of the project will be to match wastewater or biosolids facilities that need to reduce biosolids odors with specific technologies, chemicals, or biological agents, in order to demonstrate the efficacy of promising laboratory findings full scale at a real WWTP. PMID:18821247

  20. Science in the Eyes of Preschool Children: Findings from an Innovative Research Tool

    NASA Astrophysics Data System (ADS)

    Dubosarsky, Mia D.

    How do young children view science? Do these views reflect cultural stereotypes? When do these views develop? These fundamental questions in the field of science education have rarely been studied with the population of preschool children. One main reason is the lack of an appropriate research instrument that addresses preschool children's developmental competencies. Extensive body of research has pointed at the significance of early childhood experiences in developing positive attitudes and interests toward learning in general and the learning of science in particular. Theoretical and empirical research suggests that stereotypical views of science may be replaced by authentic views following inquiry science experience. However, no preschool science intervention program could be designed without a reliable instrument that provides baseline information about preschool children's current views of science. The current study presents preschool children's views of science as gathered from a pioneering research tool. This tool, in the form of a computer "game," does not require reading, writing, or expressive language skills and is operated by the children. The program engages children in several simple tasks involving picture recognition and yes/no answers in order to reveal their views about science. The study was conducted with 120 preschool children in two phases and found that by the age of 4 years, participants possess an emergent concept of science. Gender and school differences were detected. Findings from this interdisciplinary study will contribute to the fields of early childhood, science education, learning technologies, program evaluation, and early childhood curriculum development.

  1. Judging Social Issues: Difficulties, Inconsistencies, and Consistencies.

    ERIC Educational Resources Information Center

    Turiel, Elliot; And Others

    1991-01-01

    Three studies examined high school and college students' reasoning about issues of abortion, homosexuality, pornography, and incest. In the first study, groups differed in judgments about these issues but not about moral issues in general. Findings of second study paralleled those of first. Third study showed that assumptions associated with…

  2. Judges' views of child sexual abuse: evaluating beliefs against research findings in a Finnish sample.

    PubMed

    Korkman, Julia; Svanbäck, Jatta; Finnilä, Katarina; Santtila, Pekka

    2014-10-01

    Beliefs impact our decision-making and different professionals have been shown to have beliefs about child sexual abuse (CSA) that do not coincide with scientific findings. In the present study, judges' beliefs regarding CSA were explored. Finnish judges (N = 104) answered a questionnaire about CSA related issues as well as questions regarding their professional experience of CSA cases. The judges held both correct and incorrect beliefs; while their CSA prevalence estimates were rather well in line with research findings, half of the participants estimated that no professionals use suggestive methods when interviewing children and more than 40% thought suggestive methods can be useful when trying to get a child to tell about real events. Judges correctly assumed symptoms cannot be used to assess a CSA case, however, the majority thought play observations were appropriate means for evaluating such suspicions. Experience seemed to lead to more confidence in their own expertise but not in an actual increase in knowledge, namely, judges thought themselves more expert when more experienced although their expertise as measured by the questionnaire did not improve. Overall, the judges had both correct and erroneous beliefs but while experience did not improve the situation, gaining information about CSA did. More research about the beliefs of judges and how such beliefs impact legal decision-making is needed. PMID:25040839

  3. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...respondent of findings of research misconduct and HHS administrative actions. 93.405 Section...respondent of findings of research misconduct and HHS administrative actions. (a) When the...misconduct or seeks to impose or enforce HHS administrative actions, other than...

  4. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...respondent of findings of research misconduct and HHS administrative actions. 93.405 Section...respondent of findings of research misconduct and HHS administrative actions. (a) When the...misconduct or seeks to impose or enforce HHS administrative actions, other than...

  5. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...respondent of findings of research misconduct and HHS administrative actions. 93.405 Section...respondent of findings of research misconduct and HHS administrative actions. (a) When the...misconduct or seeks to impose or enforce HHS administrative actions, other than...

  6. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...respondent of findings of research misconduct and HHS administrative actions. 93.405 Section...respondent of findings of research misconduct and HHS administrative actions. (a) When the...misconduct or seeks to impose or enforce HHS administrative actions, other than...

  7. Digital animation as a method to disseminate research findings to the community using a community-based participatory approach.

    PubMed

    Vaughn, Nicole A; Jacoby, Sara F; Williams, Thalia; Guerra, Terry; Thomas, Nicole A; Richmond, Therese S

    2013-03-01

    Community-based participatory research (CBPR) has garnered increasing interest over the previous two decades as researchers have tackled increasingly complex health problems. In academia, professional presentations and articles are major ways that research is disseminated. However, dissemination of research findings to the people and communities who participated in the research is many times forgotten. In addition, little scholarly literature is focused on creative dissemination of research findings to the community using CBPR methods. We seek to fill this gap in the literature by providing an exemplar of research dissemination and partnership strategies that were used to complete this project. In this paper, we present a novel approach to the dissemination of research findings to our targeted communities through digital animation. We also provide the foundational thinking and specific steps that were taken to select this specific dissemination product development and distribution strategy. PMID:22395365

  8. Application of research findings and summary of research needs: Bud Britton Memorial Symposium on Metabolic Disorders of Feedlot Cattle.

    PubMed

    Galyean, M L; Eng, K S

    1998-01-01

    Updated research findings with acidosis, feedlot bloat, liver abscesses, and sudden death syndromes were presented at the Bud Britton Memorial Symposium on Metabolic Disorders of Feedlot Cattle. Possible industry applications include the need to establish guidelines for use of clostridial vaccines in feedlot cattle, further assessment of the relationship between acidosis and polioencephalomalacia, examination of the effects of various ionophores on the incidence of metabolic disorders, and evaluation of the effects of feed bunk management and limit- and restricted-feeding programs on the incidence of metabolic disorders. A multidisciplinary approach among researchers, consulting nutritionists and veterinarians, and feedlot managers will be required for effective progress in research and in the application of research findings. Areas suggested for further research include 1) assessment of feed consumption patterns and social behavior of cattle in large-pen, feedlot settings; 2) evaluation of the relationship between feed intake management systems (feed bunk management programs, limit- and programmed-feeding) and the incidence of metabolic disorders, including delineation of the role of variability in feed intake in the etiology of such disorders; 3) efforts to improve antemortem and postmortem diagnosis, and to establish standardized regional or national epidemiological databases for various metabolic disorders; 4) ascertaining the accuracy of diagnosis of metabolic disorders and determining the relationship of previous health history of animals to the incidence of metabolic disorders; 5) further defining ruminal and intestinal microbiology as it relates to metabolic disorders and deeper evaluation of metabolic changes that occur with such disorders; 6) continued appraisal of the effects of grain processing and specific feed ingredients and nutrients on metabolic disorders, and development of new feed additives to control or prevent these disorders; and 7) application of biotechnology to develop grain varieties with altered nutrient degradation profiles that decrease the propensity for disastrous acid loads in the rumen, feed-grade enzymes and probiotics that modify nutrient digestion or microbial profiles in the rumen and intestine, and specific strains of ruminal bacteria and protozoa that alter ruminal and metabolic conditions that may precipitate metabolic disorders. PMID:9464915

  9. Findings of the US Research Needs Workshop on the Topic of Fusion Power

    SciTech Connect

    Meier, W R; Raffray, A R; Kurtz, R J; Morley, N B; Reiersen, W T; Sharpe, P; Willms, S

    2009-09-16

    The US Department of Energy, Office of Fusion Energy Sciences (OFES) conducted a Research Needs Workshop, referred to as ReNeW, in June 2009. The information developed at this workshop will help OFES develop a plan for US fusion research during the ITER era, roughly the next two decades. The workshop was organized in five Themes, one of which was Harnessing Fusion Power (or Fusion Power for short). The top level goal of the Fusion Power Theme was to identify the research needed to develop the knowledge to design and build, with high confidence, robust and reliable systems that can convert fusion products to useful forms of energy in a reactor environment, including a self-sufficient supply of tritium fuel. Each Theme was subsequently subdivided into Panels to address specific topics. The Fusion Power Panel topics were: fusion fuel cycle; power extraction; materials science; safety and environment; and reliability, availability, maintainability and inspectability (RAMI). Here we present the key findings of the Fusion Power Theme.

  10. Exome Sequencing and Unrelated Findings in the Context of Complex Disease Research: Ethical and Clinical Implications

    PubMed Central

    Lyon, Gholson J.; Jiang, Tao; Van Wijk, Richard; Wang, Wei; Bodily, Paul Mark; Xing, Jinchuan; Tian, Lifeng; Robison, Reid J.; Clement, Mark; Lin, Yang; Zhang, Peng; Liu, Ying; Moore, Barry; Glessner, Joseph T.; Elia, Josephine; Reimherr, Fred; van Solinge, Wouter W.; Yandell, Mark; Hakonarson, Hakon; Wang, Jun; Johnson, William Evan; Wei, Zhi; Wang, Kai

    2012-01-01

    Exome sequencing has identified the causes of several Mendelian diseases, although it has rarely been used in a clinical setting to diagnose the genetic cause of an idiopathic disorder in a single patient. We performed exome sequencing on a pedigree with several members affected with attention deficit/hyperactivity disorder (ADHD), in an effort to identify candidate variants predisposing to this complex disease. While we did identify some rare variants that might predispose to ADHD, we have not yet proven the causality for any of them. However, over the course of the study, one subject was discovered to have idiopathic hemolytic anemia (IHA), which was suspected to be genetic in origin. Analysis of this subject’s exome readily identified two rare non-synonymous mutations in PKLR gene as the most likely cause of the IHA, although these two mutations had not been documented before in a single individual. We further confirmed the deficiency by functional biochemical testing, consistent with a diagnosis of red blood cell pyruvate kinase deficiency. Our study implies that exome and genome sequencing will certainly reveal additional rare variation causative for even well-studied classical Mendelian diseases, while also revealing variants that might play a role in complex diseases. Furthermore, our study has clinical and ethical implications for exome and genome sequencing in a research setting; how to handle unrelated findings of clinical significance, in the context of originally planned complex disease research, remains a largely uncharted area for clinicians and researchers. PMID:21794208

  11. Small parts aspiration, ingestion, and choking in small children: findings of the small parts research project.

    PubMed

    Rider, G; Wilson, C L

    1996-06-01

    Obtaining information on current child injury trends and their associated issues is an important factor in developing products that meet or surpass acceptable toy safety boundaries. Understanding these boundaries helps determine safe product design characteristics that reduce the risk of product-related injury. Inchcape Testing Services developed a Small Parts Aspiration, Ingestion, and Choking Hazards Research Project, independent of an ongoing consumer Product Safety Commission (CPSC) project. The project's purpose was to determine, independent of CPSC, whether a more stringent small parts regulatory standard was necessary and, if so, to ensure that the standard was determined objectively. This article reports on the project's findings relating to critical characteristics (size, shape, and consistency) relative to the victim's age, of objects responsible for child choking injuries and fatalities. PMID:8693159

  12. Unanticipated findings in pediatric neuroimaging research: Prevalence of abnormalities and process for reporting and clinical follow-up.

    PubMed

    Kaiser, Drew; Leach, James; Vannest, Jennifer; Schapiro, Mark; Holland, Scott

    2015-03-01

    MRI is a powerful tool to evaluate brain anatomy and function in normal children and its use in research applications has steadily increased. As imaging technology improves, and sensitivity to brain pathology increases, unanticipated (and potentially clinically important) findings on research neuroimaging studies will also increase. We evaluated the prevalence and type of unanticipated and potentially clinically significant imaging findings in a group of 114 normal children enrolled in an ongoing MRI imaging study of normal brain development for the Pediatric Functional Neuroimaging Research Network. Brain imaging findings were classified using standardized scales developed for the Network and findings were reported to participants and their primary healthcare provider according to a standard reporting pathway. Classification scales, reporting processes, and illustrated examples of findings are included and discussed. Unanticipated imaging findings were identified in approximately 12.5 % of children participating in this study. PMID:25403715

  13. Assessing the acceptability of NORPLANT implants in four countries: findings from focus group research.

    PubMed

    Zimmerman, M; Haffey, J; Crane, E; Szumowski, D; Alvarez, F; Bhiromrut, P; Brache, V; Lubis, F; Salah, M; Shaaban, M

    1990-01-01

    In 1986-87, a qualitative research project was conducted in the Dominican Republic, Egypt, Indonesia, and Thailand to expand understanding of the acceptability of NORPLANT contraceptive implants beyond inferences made on the basis of continuation rates. In each of the four study sites, focus group discussions or in-depth interviews were held with potential acceptors, current NORPLANT users, discontinuers, husbands of women in these three groups, and service providers. Nonclinical participants generally had little formal education and lived primarily in urban or semi-urban areas where NORPLANT has been available for at least five years. The study focused on attitudes, perceptions, and experiences of each group regarding NORPLANT implants. Results suggest that factors having an impact on the acceptability of NORPLANT implants fall into three general categories: medical/technical, cultural/religious, and informational/educational. This article discusses each of these categories, including programmatic implications of the findings, and puts forward recommendations for enhancing NORPLANT introduction efforts on the basis of these findings. PMID:2112794

  14. Specific language impairment in children: research findings and their therapeutic implications.

    PubMed

    van der Lely, H K

    1993-01-01

    This paper reports the findings from a research project investigating a subgroup of specifically language-impaired (SLI) children. The subgroup of SLI children consists of those characterised by persisting grammatical deficits in comprehension and expression of language. The paper summarises the findings in order to highlight the therapeutic implications from the investigations. The main focus of the investigations was to characterise the SLI children's grammatical knowledge of sentence comprehension, specifically their ability to learn the semantic and syntactic properties of verbs. In addition, an investigation of verbal short-term memory (STM) was carried out, and an analysis was undertaken of the expressive morpho-grammatical characteristics of the children. The investigations revealed that the SLI children did not differ in their STM abilities from children carefully matched on language abilities. Thus, the data do not provide support for therapy directed at increasing auditory memory with an aim of improving expression or comprehension of sentences. It is hypothesised that the SLI children have a deficit in syntactic representations and are unable to specify the structural relationships between constituents in syntax. The implications of the study are that this subgroup of SLI children may be unable to use syntactic cues to help learn semantic properties of verbs, but semantic cues may facilitate learning the syntactic properties of verbs. PMID:8241580

  15. Clique-Finding for Heterogeneity and Multidimensionality in Biomarker Epidemiology Research: The CHAMBER Algorithm

    PubMed Central

    Mushlin, Richard A.; Gallagher, Stephen; Kershenbaum, Aaron; Rebbeck, Timothy R.

    2009-01-01

    Background Commonly-occurring disease etiology may involve complex combinations of genes and exposures resulting in etiologic heterogeneity. We present a computational algorithm that employs clique-finding for heterogeneity and multidimensionality in biomedical and epidemiological research (the “CHAMBER” algorithm). Methodology/Principal Findings This algorithm uses graph-building to (1) identify genetic variants that influence disease risk and (2) predict individuals at risk for disease based on inherited genotype. We use a set-covering algorithm to identify optimal cliques and a Boolean function that identifies etiologically heterogeneous groups of individuals. We evaluated this approach using simulated case-control genotype-disease associations involving two- and four-gene patterns. The CHAMBER algorithm correctly identified these simulated etiologies. We also used two population-based case-control studies of breast and endometrial cancer in African American and Caucasian women considering data on genotypes involved in steroid hormone metabolism. We identified novel patterns in both cancer sites that involved genes that sulfate or glucuronidate estrogens or catecholestrogens. These associations were consistent with the hypothesized biological functions of these genes. We also identified cliques representing the joint effect of multiple candidate genes in all groups, suggesting the existence of biologically plausible combinations of hormone metabolism genes in both breast and endometrial cancer in both races. Conclusions The CHAMBER algorithm may have utility in exploring the multifactorial etiology and etiologic heterogeneity in complex disease. PMID:19287484

  16. Apparent Inconsistencies in the Formation of Cometary Matter

    NASA Astrophysics Data System (ADS)

    Huebner, W. F.; Keller, H. U.

    2005-01-01

    We will summarize the papers of the Joint Discussion 14 following the scheme of the introduction (W.F. Huebner and H.U. Keller) and highlight where inconsistencies have been solved confirmed or established by the presented contributions.

  17. Rape treatment outcome research: empirical findings and state of the literature.

    PubMed

    Vickerman, Katrina A; Margolin, Gayla

    2009-07-01

    This article reviews empirical support for treatments targeting women sexually assaulted during adolescence or adulthood. Thirty-two articles were located using data from 20 separate samples. Of the 20 samples, 12 targeted victims with chronic symptoms, three focused on the acute period post-assault, two included women with chronic and acute symptoms, and three were secondary prevention programs. The majority of studies focus on posttraumatic stress disorder (PTSD), depression, and/or anxiety as treatment targets. Cognitive Processing Therapy and Prolonged Exposure have garnered the most support with this population. Stress Inoculation Training and Eye Movement Desensitization and Reprocessing also show some efficacy. Of the four studies that compared active treatments, few differences were found. Overall, cognitive behavioral interventions lead to better PTSD outcomes than supportive counseling does. However, even in the strongest treatments more than one-third of women retain a PTSD diagnosis at post-treatment or drop out of treatment. Discussion highlights the paucity of research in this area, methodological limitations of examined studies, generalizability of findings, and important directions for future research at various stages of trauma recovery. PMID:19442425

  18. Preprocessing Inconsistent Linear System for a Meaningful Least Squares Solution

    NASA Technical Reports Server (NTRS)

    Sen, Syamal K.; Shaykhian, Gholam Ali

    2011-01-01

    Mathematical models of many physical/statistical problems are systems of linear equations. Due to measurement and possible human errors/mistakes in modeling/data, as well as due to certain assumptions to reduce complexity, inconsistency (contradiction) is injected into the model, viz. the linear system. While any inconsistent system irrespective of the degree of inconsistency has always a least-squares solution, one needs to check whether an equation is too much inconsistent or, equivalently too much contradictory. Such an equation will affect/distort the least-squares solution to such an extent that renders it unacceptable/unfit to be used in a real-world application. We propose an algorithm which (i) prunes numerically redundant linear equations from the system as these do not add any new information to the model, (ii) detects contradictory linear equations along with their degree of contradiction (inconsistency index), (iii) removes those equations presumed to be too contradictory, and then (iv) obtain the minimum norm least-squares solution of the acceptably inconsistent reduced linear system. The algorithm presented in Matlab reduces the computational and storage complexities and also improves the accuracy of the solution. It also provides the necessary warning about the existence of too much contradiction in the model. In addition, we suggest a thorough relook into the mathematical modeling to determine the reason why unacceptable contradiction has occurred thus prompting us to make necessary corrections/modifications to the models - both mathematical and, if necessary, physical.

  19. St. Jude researchers find that unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors

    Cancer.gov

    St. Jude Children’s Research Hospital study finds that few adult survivors of childhood cancer follow a heart-healthy lifestyle that protects against heart disease, diabetes and other health problems.

  20. Can I be sued for that? Liability risk and the disclosure of clinically significant genetic research findings

    PubMed Central

    McGuire, Amy L.; Knoppers, Bartha Maria; Zawati, Ma’n H.; Clayton, Ellen Wright

    2014-01-01

    Genomic researchers increasingly are faced with difficult decisions about whether, under what circumstances, and how to return research results and significant incidental findings to study participants. Many have argued that there is an ethical—maybe even a legal—obligation to disclose significant findings under some circumstances. At the international level, over the last decade there has begun to emerge a clear legal obligation to return significant findings discovered during the course of research. However, there is no explicit legal duty to disclose in the United States. This creates legal uncertainty that may lead to unmanaged variation in practice and poor quality care. This article discusses liability risks associated with the disclosure of significant research findings for investigators in the United States. PMID:24676095

  1. Summaries of Conference Papers, Theme 1, Research Findings. International Conference on Evaluation and Research in Educational Television and Radio (Milton Keynes, England, April 9-13, 1976).

    ERIC Educational Resources Information Center

    Open Univ., Walton, Bletchley, Bucks (England).

    Educational television and radio research and evaluation findings are the subject of 25 papers summarized in this document. Seven papers deal with evaluation of research projects in educational television and radio. Four papers on adult education and two on educational technology in teacher training are also summarized. Research in teaching with…

  2. Problems Teachers Face When Doing Action Research and Finding Possible Solutions: Three Cases

    ERIC Educational Resources Information Center

    Zhou, Jun

    2012-01-01

    Through case studies, this paper explores problems teachers face when doing action research: for instance, teachers may misunderstand the research, mistrust university researchers, lack the time or adequate library resources to conduct research, lack theoretical guidance or knowledge of research methodology, and feel pressure or frustration during…

  3. Determinants of nursing home costs in Florida: policy implications and support in national research findings.

    PubMed Central

    Traxler, H G

    1982-01-01

    Descriptive and econometric analysis of the major nonquality determinants of nursing home costs for Florida shows that mean costs, size, and occupancy rate increased between 1971 and 1976, that per diem costs and occupancy rate were inversely related, and that the per diem cost was lower in rural than in urban areas. Regression of the data shows that--next to inflation, as expressed by the Consumer Price Index--the occupancy rate accounts for most of the variation in per diem costs, followed by size, urban-rural location, and by type of control. The hypothetical "optimal," defined as lowest cost-size range, was calculated to be more than 350 beds. Recent research substantiates most of these findings. Medicaid Cost Reports from Florida's nursing homes were the source of the information analyzed; by 1976, the sixth year of the study, the data base covered nearly 9 of 10 licensed beds in the State. Some policy implications can be drawn from the analysis. Reductions in per diem costs could be achieved by higher occupancy rates, especially in the larger nursing homes, and a reduction in the rate of inflation would reduce the rate of increase in nursing home costs. PMID:6815706

  4. Research on the effect of noise at different times of day: Models, methods and findings

    NASA Technical Reports Server (NTRS)

    Fields, J. M.

    1985-01-01

    Social surveys of residents' responses to noise at different times of day are reviewed. Some of the discrepancies in published reports about the importance of noise at different times of day are reduced when the research findings are classified according to the type of time of day reaction model, the type of time of day weight calculated and the method which is used to estimate the weight. When the estimates of nighttime weights from 12 studies are normalized, it is found that they still disagree, but do not support stronger nighttime weights than those used in existing noise indices. Challenges to common assumptions in nighttime response models are evaluated. Two of these challenges receive enough support to warrant further investigation: the impact of changes in numbers of noise events may be less at night than in the day and nighttime annoyance may be affected by noise levels in other periods. All existing social survey results in which averages of nighttime responses were plotted by nighttime noise levels are reproduced.

  5. Thomas Jefferson University researchers find new biomarker to identify hepatitis B-infected patients at risk for liver cancer

    Cancer.gov

    Hepatitis B-infected patients with significantly longer telomeres—the caps on the end of chromosomes that protect our genetic data— were found to have an increased risk of getting liver cancer compared to those with shorter ones, according to findings presented by researchers at Jefferson’s Kimmel Cancer Center at the American Association for Cancer Research (AACR) Annual Meeting 2012.

  6. Changing the behavior of healthcare professionals: the use of theory in promoting the uptake of research findings

    Microsoft Academic Search

    Martin Eccles; Jeremy Grimshaw; Anne Walker; Marie Johnston; Nigel Pitts

    Abstract Objective: The uptake of research findings into routine health care is a haphazard and unpredictable process. The usefulness of the results of implementation studies is limited, due in part to the lack of an underlying framework of the important dimensions of research studies in this area and the healthcare settings within which they are conducted,and may,subsequently be used. Study

  7. Impact of Problem Finding on the Quality of Authentic Open Inquiry Science Research Projects

    ERIC Educational Resources Information Center

    LaBanca, Frank

    2008-01-01

    Problem finding is a creative process whereby individuals develop original ideas for study. Secondary science students who successfully participate in authentic, novel, open inquiry studies must engage in problem finding to determine viable and suitable topics. This study examined problem finding strategies employed by students who successfully…

  8. 48 CFR 52.225-14 - Inconsistency between English Version and Translation of Contract.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...2010-10-01 false Inconsistency between English Version and Translation of Contract... 52.225-14 Inconsistency between English Version and Translation of Contract...following clause: Inconsistency Between English Version and Translation of...

  9. 26 CFR 1.1311(b)-1 - Maintenance of an inconsistent position.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...false Maintenance of an inconsistent position. 1.1311(b)-1 Section 1...1 Maintenance of an inconsistent position. (a) In general. Under the circumstances...1312-7, the maintenance of an inconsistent position is a condition necessary for...

  10. 26 CFR 1.1311(b)-1 - Maintenance of an inconsistent position.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...false Maintenance of an inconsistent position. 1.1311(b)-1 Section 1...1 Maintenance of an inconsistent position. (a) In general. Under the circumstances...1312-7, the maintenance of an inconsistent position is a condition necessary for...

  11. 26 CFR 1.1311(b)-1 - Maintenance of an inconsistent position.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...true Maintenance of an inconsistent position. 1.1311(b)-1 Section 1...1 Maintenance of an inconsistent position. (a) In general. Under the circumstances...1312-7, the maintenance of an inconsistent position is a condition necessary for...

  12. 26 CFR 1.1311(b)-1 - Maintenance of an inconsistent position.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...false Maintenance of an inconsistent position. 1.1311(b)-1 Section 1...1 Maintenance of an inconsistent position. (a) In general. Under the circumstances...1312-7, the maintenance of an inconsistent position is a condition necessary for...

  13. 26 CFR 1.1311(b)-1 - Maintenance of an inconsistent position.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...false Maintenance of an inconsistent position. 1.1311(b)-1 Section 1...1 Maintenance of an inconsistent position. (a) In general. Under the circumstances...1312-7, the maintenance of an inconsistent position is a condition necessary for...

  14. Belief, its inconsistency, and the implications for the teaching faculty

    PubMed Central

    Fraley, Lawrence E.

    1984-01-01

    The traditional concept of belief is analyzed and compared with a behavior analytic concept of belief. Beliefs and belief statements are differentiated and relationships between them are examined. The often troublesome inconsistencies in people's beliefs are examined in general and explained, including the phenomena of compartmentalization and repression. Social implications are pursued relative to both punishment for inconsistency in belief and counter-controls thwarting such punishment. The role of teachers in shaping beliefs is analyzed, and appropriate teaching strategies are reviewed. PMID:22478593

  15. Directions for future research in project management: The main findings of a UK government-funded research network

    Microsoft Academic Search

    Mark Winter; Charles Smith; Peter Morris; Svetlana Cicmil

    2006-01-01

    In 2003 the UK’s Engineering and Physical Sciences Research Council (EPSRC) agreed to fund a research network –Rethinking Project Management – to define a research agenda aimed at enriching and extending the subject of project management beyond its current conceptual foundations. The main argument for the proposed Network highlighted the growing critiques of project management theory and the need for

  16. Purdue study finds "label-free" imaging tool tracks nanotubes in cells, blood for biomedical research:

    Cancer.gov

    Purdue University researchers have demonstrated a new imaging tool for tracking structures called carbon nanotubes in living cells and the bloodstream, which could aid efforts to perfect their use in biomedical research and clinical medicine.

  17. Sanford-Burnham researchers find RNA molecules in urine, tissue that detect prostate cancer

    Cancer.gov

    Researchers at Sanford-Burnham Medical Research Institute have identified a set of RNA molecules that are detectable in tissue samples and urine of prostate cancer patients, but not in normal healthy individuals.

  18. Turning a negative into a positive: Researchers find promising use for excessive nitrate

    E-print Network

    Wythe, Kathy

    2009-01-01

    Dr. Cristine Morgan, Texas AgriLife Research soil scientist, takes soil cores for nitrate analysis before the drip irrigation system was installed. Story by Kathy Wythe Turning a negative into a positive Researchers fi nd promising use... for excessive nitrate For 30 years, farmers in northwest central Texas have known that high level of nitrates in irrigation water from the Seymour Aquifer is a problem. Now, with research conducted by Texas AgriLife Research scientists, that problem may...

  19. Teaching, Learning and Assessing HRD: Findings from a BMAF/UFHRD Research Project

    ERIC Educational Resources Information Center

    Sambrook, Sally; Stewart, Jim

    2010-01-01

    Purpose: This paper seeks to analyse and explore the results of a research project, which aimed to identify recent and current research on TLA within HRD programmes. From that base the project also intended to identify areas for future research and a basis for establishing a Special Interest Group. Design/methodology/approach: A comprehensive…

  20. Research in Online and Blended Learning in the Business Disciplines: Key Findings and Possible Future Directions

    ERIC Educational Resources Information Center

    Arbaugh, J. B.; Godfrey, Michael R.; Johnson, Marianne; Pollack, Birgit Leisen; Niendorf, Bruce; Wresch, William

    2009-01-01

    In this literature review, we examine and assess the state of research of online and blended learning in the business disciplines with the intent of assessing the state of the field and identifying opportunities for meaningful future research. We review research from business disciplines such as Accounting, Economics, Finance, Information Systems…

  1. ORI findings of scientific misconduct in clinical trials and publicly funded research, 1992–2002

    Microsoft Academic Search

    Sandra M Reynolds

    2004-01-01

    Background Since 1992 the Office of Research Integrity (ORI) had reviewed investigations of scientific misconduct in research funded by the US Public Health Service (PHS). ORI defined scientific misconduct as “fabrication, falsification, plagiarism, or other practices that seriously deviate from those that are commonly accepted within the scientific community for proposing, conducting, or reporting research”.Purpose The purpose of this study

  2. Formal Training, Personal Experience, and the Ability to Predict Research Findings in Social Psychology

    Microsoft Academic Search

    Carrie Quarterman

    2007-01-01

    Researchers in the past have found that personal experience and formal training lead to better accuracy when predicting research outcomes in areas of psychology. Personal experience and formal training were compared in this study on the ability of students to predict research outcomes in social psychology. Students completed questionnaires that measured their social engagement (a proxy to personal experience), their

  3. The Hermeneutic Dialogic: Finding Patterns midst the "Aporia" of the Artist/Researcher/Teacher.

    ERIC Educational Resources Information Center

    de Cosson, Alex

    This paper considers one researcher's challenge of marking his progress in reading/studying Jacques Derrida's "Aporias" (1993) by what he calls the continual hermeneutic of making meaning. The paper places the "Aporias" reading in the setting of a weekly research group whose research cycle was creating meaning in and out of the work being done and…

  4. Summary Report on Action Research: A Summary of Findings on a Series of Action Research Projects Conducted by Goshen Community Schools

    ERIC Educational Resources Information Center

    Haystead, Mark W.

    2009-01-01

    This report summarizes the findings of an analysis of a series of action research projects conducted by Goshen Community Schools at the elementary, middle, and high school levels. During the 2008-2009 school year, 40 teachers participated in independent action research studies regarding the extent to which a six step approach to direct vocabulary…

  5. Challenge: Reframing, communicating, and finding relevance. Solution: Teachers on the research team

    NASA Astrophysics Data System (ADS)

    Bartholow, S.; Warburton, J.

    2013-12-01

    PolarTREC (Teachers and Researchers Exploring and Collaborating) is a program in which K-12 teachers spend 2-6 weeks participating in hands-on field research experiences in the polar regions. The goal of PolarTREC is to invigorate polar science education and understanding by bringing K-12 educators and polar researchers together. Program data has illuminated a crucial dynamic that increases the potential for a successful climate change science campaign. We contend that the inclusion of a teacher into the field research campaign can tackle challenges such as reframing climate change science to better address the need for a particular campaign, as well as garnering the science project the necessary support through effective, authentic, and tangible communication efforts to policymakers, funders, students, and the public. The program evaluation queried researchers on a.) the teachers' primary roles in the field b.) the impact teachers on the team's field research, and c.) the teachers' role conducting outreach. Additionally, researchers identified the importance of the facilitator, the Arctic Research Consortium of the United States (ARCUS), as an integral component to the challenge of providing a meaningful broader impact statement to the science proposal. Researchers reported the value of explaining their science, in-situ, allowed them to reframe and rework the objectives of the science project to attain meaningful outcomes. More than half of the researchers specifically noted that one of the strengths of the PolarTREC project is its benefit to the scientific process. The researchers also viewed PolarTREC as an essential outreach activity for their research project. Other researchers said that the outreach provided by their teacher also improved the research project's public image and articulated complex ideas to the public at large. This presentation will speak to the practices within the PolarTREC program and how researchers can meet outreach expectations, impact the public, and refine their science with teachers in the field.

  6. The crystalline revolution :ISO's finding opens a new research field, "astro-mineralogy"

    NASA Astrophysics Data System (ADS)

    2000-02-01

    Silicate minerals were known to be a main component of dust in space, but detecting them in a crystallised state has been a surprise. It allows the identification of precise silicates in astronomical objects, which will open "a totally new field in astronomy: astro-mineralogy. This is the crystalline revolution", said the author, Dutch astronomer Rens Waters of Amsterdam university. "It's really fantastic, this possibility of identifying the silicates. Before ISO everybody thought that all silicates in space were amorphous, without a well-ordered internal structure; that means you cannot differentiate among the many different silicates existing. Now we can try to identify them and track their presence in different regions. A whole new research field is starting", said Rens Waters, who brought to the press conference samples of several terrestrial crystalline silicates: olivine and pyroxene, the most common silicates on Earth. Crystals give key clues about the physical conditions and evolutionary history of crystal-bearing objects. The precise mechanisms for crystal-making are now being researched now very actively in the laboratories, although some working-hypotheses are already being used. For instance, crystals can be made by heating the material to temperatures above 1 300 degrees Centigrade and then cooling it down slowly. Those found so far by ISO are at -170 degrees Centigrade, both in stellar envelopes and in protoplanetary discs. In the case of the old stars -red giant stars, where crystals are found to account for as much as 20% of all the surrounding dust, astronomers think that that the high temperatures near the star triggered the crystallisation of the silicates. In the protoplanetary discs some experts postulate that electric shocks - like lightning flashes - heated the dust, which cooled afterwards. "The crystals detected by ISO in these discs have a size of about a thousandth of a millimetre. They collide with each other, forming bigger and bigger bodies. Models predict that in about ten to one hundred million years they will make planets", Waters says. "In fact, crystalline silicates are very common in our own Solar System. You also have them in the comet Hale Bopp!". The reason why crystalline silicates had not been detected before in stars has to do with their low temperatures. Cold material emits mostly infrared light, which means an infrared space telescope like ESA's ISO was needed. The two high-resolution spectrometers on-board the satellite, able to detect the 'chemical fingerprint' of the crystals, did the rest. Astronomers are sure about the discovery because those chemical fingerprints, the spectra, can be compared in laboratories with spectra from crystalline silicates found on Earth. This method has demonstrated the crystalline structure and has even already allowed the identification of some of the crystals, such as forsterite and enstatite. However, crystalline silicates are a large family and their chemical signatures can be very similar; to enlarge the list of precise crystals more work will be needed, say experts in space chemistry. That is just one of the open questions requiring lab work. There's at least another one: crystalline silicates are found around old stars, in protoplanetary disks and in our own Solar System, but not in the space among the stars; astronomers can't explain it yet. "Crystalline silicates are synthesised around the stars; then that dust goes into the interstellar space, and enriches the raw material out of which more stars and planets will form. So you would expect crystals also to be in the interstellar medium! Crystals will certainly make us learn a lot...", says Waters. "This finding shows that ISO is really unveiling the chemistry of the Universe", says ESA astronomer Alberto Salama, chairman of the workshop about ISO results in spectroscopy held this week at ESA's Villafranca station in Madrid where the results were presented to the scientific community. "This is becoming more and more a 'hot

  7. Detecting and Characterizing Semantic Inconsistencies in Ported Code

    E-print Network

    Kim, Miryung

    BSD, NetBSD, and FreeBSD found that 11% to 16% code changes are ported from peer projects [18]. Also, when, unintentional inconsistent changes to clones lead to a fault" [10]. Li et al. identify errors in Linux and FreeBSD work backwards by first mining the version histories of Linux and FreeBSD to detect commit messages

  8. Redundancy and Inconsistency Detection in Large and Unstructured Case Bases

    E-print Network

    Zhang, Richard "Hao"

    and difficult to maintain. One of the contributing factors is that these case bases are often large and yet and inconsistency naturally and effortlessly. Empirical evaluations of the system prove the effective­ ness by storing entire cases for later analysis, rather than asking the domain experts to encode their knowledge

  9. Self-Reported Cognitive Inconsistency in Older Adults

    Microsoft Academic Search

    Susan Vanderhill; David F. Hultsch; Michael A. Hunter; Esther Strauss

    2010-01-01

    Insight into one's own cognitive abilities, or metacognition, has been widely studied in developmental psychology. Relevance to the clinician is high, as memory complaints in older adults show an association with impending dementia, even after controlling for likely confounds. Another candidate marker of impending dementia under study is inconsistency in cognitive performance over short time intervals. Although there has been

  10. Scaling Factor Inconsistencies in Neutrinoless Double Beta Decay

    E-print Network

    S. Cowell

    2005-12-05

    The modern theory of neutrinoless double beta decay includes a scaling factor that has often been treated inconsistently in the literature. The nuclear contribution to the decay half life can be suppressed by 15-20% when scaling factors are mismatched. Correspondingly, $$ is overestimated.

  11. Intra-word inconsistency in apraxic Hebrew-speaking children.

    PubMed

    Tubul-Lavy, Gila

    2012-06-01

    Intra-word inconsistency in a child is perceived as an indicator of speech impairment. Because the speech of typically developing children is highly variable, the extent and nature of the inconsistency must be defined when used as a diagnostic marker of speech impairment (McLeod, S., & Hewett, S. R. (2008). Variability in the production of words containing consonant clusters by typical 2- and 3-year-old children. Folia Phoniatrica et Logopaedica, 60(4), 163-172). In this paper, we study inconsistency with reference to the prosodic hierarchy (McCarthy, J. J., & Prince, A. S. (1996). Prosodic morphology 1986. Amherst, MA: University of Massachusetts. Retrieved April 15, 2010, from http://ruccs.rutgers.edu/pub/papers/pm86all.pdf), suggesting a new way to describe this phenomenon in childhood apraxia of speech (CAS). The prosodic hierarchy has been used in recent years to demonstrate the phonological development of typical and atypical populations. Sixteen children diagnosed with CAS (average age 3;11) participated in the study. The data, collected from each child in the course of eight weekly meetings, are drawn from naming single words. The results indicate that inconsistency is dominant for two prosodic levels, the segmental and the syllabic, while the prosodic word level was largely preserved. PMID:22540359

  12. Camera calibration correction in shape from inconsistent silhouette

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The use of shape from silhouette for reconstruction tasks is plagued by two types of real-world errors: camera calibration error and silhouette segmentation error. When either error is present, we call the problem the Shape from Inconsistent Silhouette (SfIS) problem. In this paper, we show how sm...

  13. Supporting Automatic Model Inconsistency Fixing Yingfei Xiong1

    E-print Network

    Czarnecki, Krzysztof

    Supporting Automatic Model Inconsistency Fixing Yingfei Xiong1 , Zhenjiang Hu2 , Haiyan Zhao3 , Hui Tokyo 113-8656, Japan xiong@ipl.t.u-tokyo.ac.jp takeichi@mist.i.u- tokyo.ac.jp 2 GRACE Center National

  14. Inconsistent Condom Use among Iranian Male Drug Injectors

    PubMed Central

    Assari, Shervin; Yarmohmmadi Vasel, Mosaieb; Tavakoli, Mahmood; Sehat, Mahmoud; Jafari, Firoozeh; Narenjiha, Hooman; Rafiey, Hassan; Ahmadi, Khodabakhsh

    2014-01-01

    Objectives: The aim of this study was to determine the prevalence and associated factors of inconsistent condom use among Iranian male injecting drug users (IDUs). Materials and Methods: Data came from the national Iranian behavioral survey of drug dependence, which sampled 7743 individuals with drug dependence, from medical centers, prisons, and streets in 29 provinces in Iran, in 2007. This study included all individuals who were male, IDUs, and were sexually active (n?=?1131). The main outcome was inconsistent condom use which was assessed using a single item. A logistic regression was used to determine the association between socio-economic data, drug use data, and high risk injection behaviors with inconsistent condom use. Result: 83.3% of sexually active IDUs (n?=?965) reported inconsistent condom use. Based on the logistic regression, likelihood of inconsistent condom use was higher among those with a history of syringe sharing [Odds Ratio (OR); 1.63, 95% Confidence Interval (CI); 1.13–2.34], but lower among those with higher education levels (OR; 0.34, 95% CI; 0.14–0.82), those who mostly inject at home (OR; 0.09, 95% CI; 0.02–0.47), and those with a history of treatment (OR; 0.54, 95% CI; 0.31–0.94). Conclusion: Because of the link between unsafe sex and risky injecting behaviors among Iranian IDUs, combined programs targeting both sexual and injection behavior may be more appropriate than programs that target sexual or injection behavior. The efficacy of combined programs should be, however, compared with traditional programs that only target sexual or injection behavior of IDUs. PMID:24772093

  15. Improving Hawaiian and Filipino Involvement in Clinical Research Opportunities: Qualitative Findings from Hawai'i

    PubMed Central

    Gollin, Lisa X.; Harrigan, Rosanne C.; Perez, John; Easa, David; Calderón, José L.

    2006-01-01

    Objective Investigate the barriers to participation in medical research that involves Asian and Pacific Islander (API) populations in Hawai'i. Participants Fifty people (27 Filipinos, 23 Hawaiian/Pacific Islanders) in five different communities on Oahu. Design Nine focus groups with an ethnically matched moderator were held to explore people's feelings, problems, and recommendations regarding medical research. Sessions were audiotaped, transcribed, and qualitatively analyzed with the constant comparison method. Results Only 12% of study participants said that they absolutely would not participate in a clinical study. Most agreed that research is vital. Filipino participants were more optimistic about the safety and value of joining in medical research. Hawaiian groups were more hesitant and fearful. Reasons for nonparticipation included negative feelings about the purpose and intent of clinical trials and language and cultural barriers. Suggestions on how to encourage API populations to participate in research investigations included improving peoples' understanding of the benefits to family and community. Hawaiian and Filipino groups differed only slightly in their assessments of the type of research needed in their communities. Conclusions Recruitment campaigns must improve people's awareness of the process of informed consent, research safeguards, and benefits to family and community. Attention should focus on K-12 health education to use members of the younger generations to access and educate elders, involving persons with medical research experience as a recruitment resource, returning results to study participants, and increasing the number of healthcare professionals and researchers that are culturally and linguistically matched to the community. PMID:16312944

  16. NIH Researchers Find Resveratrol Helps Protect against Cardiovascular Disease in Animal Study

    MedlinePLUS

    ... find Resveratrol helps protect against cardiovascular disease in animal study June 3, 2014 Resveratrol, a compound found ... translatable to humans. Multiple studies on resveratrol in animal models, however, have presented ample evidence to support ...

  17. Broad Claims from Slender Findings: Early Literacy Research and Educational Policy Recommendations.

    ERIC Educational Resources Information Center

    Allington, Richard L.

    A study of state educational policymaking revealed a number of instances where assertions have been made about what the "research says" in offering support for particular policies; however, in many of these instances the available research seems to have been distorted or exaggerated in order to better leverage particular policy proposals. The role…

  18. UC Irvine researchers find a cause of chemotherapy resistance in melanoma

    Cancer.gov

    Researchers with UC Irvine’s Chao Family Comprehensive Cancer Center have identified a major reason why melanoma is largely resistant to chemotherapy. The researchers found a genetic pathway in melanoma cells that inhibits the cellular mechanism for detecting DNA damage wrought by chemotherapy, thereby building up tolerance to cancer-killing drugs.

  19. A Comparative Study of International Cultural and Ethical Values: Preliminary Findings and Research Agenda

    Microsoft Academic Search

    Stephen J. J. McGuire; Angeles Lillian; Y. Fok; Kern Kwong

    This paper describes the preliminary results of an ongoing international research project to identify the cultural values and beliefs of business students and executives in several different countries and analyze the relationship between culture and reasons behind business decisions. First, we describe a research project to assess business decisions, based on established theories of ethics. Second, we describe a model

  20. Making Life Easier with Effort: Basic Findings and Applied Research on Response Effort.

    ERIC Educational Resources Information Center

    Friman, Patrick C.; Poling, Alan

    1995-01-01

    This paper summarizes basic research on response effort in diverse applied areas including deceleration of aberrant behavior, attention deficit-hyperactivity disorder, oral habits, littering, and problem solving. The paper concludes that response effort as an independent variable has potent effects, and research exploring the applied benefits of…

  1. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science

    Microsoft Academic Search

    Laura J Damschroder; David C Aron; Rosalind E Keith; Susan R Kirsh; Jeffery A Alexander; Julie C Lowery

    2009-01-01

    BACKGROUND: Many interventions found to be effective in health services research studies fail to translate into meaningful patient care outcomes across multiple contexts. Health services researchers recognize the need to evaluate not only summative outcomes but also formative outcomes to assess the extent to which implementation is effective in a specific setting, prolongs sustainability, and promotes dissemination into other settings.

  2. Concepts of School Effectiveness as Derived from Research Strategies: Differences in the Findings.

    ERIC Educational Resources Information Center

    Airasian, Peter W.; And Others

    The methodological parameters of evaluative research studies help to identify a conceptualization of the phenomenon under investigation. Holistic critiques that identify the conceptual models under which the research was conducted shed light on the validity of the disparate inferences made from a number of studies of schools and school…

  3. PRELIMINARY FINDINGS FROM THE NERL RESEARCH TRIANGLE PARK PARTICULATE MATTER PANEL STUDY

    EPA Science Inventory

    The U.S. Environmental Protection Agency is currently conducting the National Exposure Research Laboratory (NERL) Research Triangle Park (RTP) Particulate Matter (PM) Panel Study. This study represents a one year investigation of PM and related co-pollutants involving two dist...

  4. Finding the Rose Among the Thorns: Some Thoughts on Integrating Media Research.

    ERIC Educational Resources Information Center

    Angert, Jay F.; Clark, Francis E.

    A meta-analysis procedure was used to review research on pictorial effectiveness which focused on the use of static iconic visuals in instructional materials. The purpose of this exploratory study was to provide a means for forming future hypotheses based upon a quantitative aggregation of past research. The study was concerned with differential…

  5. A review of telework research: findings, new directions, and lessons for the study of modern work

    Microsoft Academic Search

    Diane E. Bailey; Nancy B. Kurland

    2002-01-01

    Summary Telework has inspired research in disciplines ranging from transportation and urban planning to ethics, law, sociology, and organizational studies. In our review of this literature, we seek answers to three questions: who participates in telework, why they do, and what happens when they do? Who teleworks remains elusive, but research suggests that male professionals and female clerical workers predominate.

  6. Cold Spring Harbor researchers find immunogenic mutations in tumor genomes correlate with increased patient survival

    Cancer.gov

    Developing immunotherapies for cancer is challenging because of significant variability among tumors and diversity in human immune types. In a study published online today in Genome Research , researchers examined the largest collection of tumor samples to date to predict patient-specific survival

  7. Research: Value-Added Assessment Findings--Poor Kids Get Poor Teachers

    ERIC Educational Resources Information Center

    Bracey, Gerald W.

    2004-01-01

    The Summer 2004 issue of Research Points, a four-page flier from the American Educational Research Association, opens with the fundamental case for value-added assessment: Today's accountability systems place the blame on schools for inadequate student academic achievement, which seems unfair to many people. They believe that family background and…

  8. Classroom Teaching Skills. The Research Findings of the Teacher Education Project.

    ERIC Educational Resources Information Center

    Wragg, E. C., Ed.

    This book describes some of the research undertaken during the Teacher Education Project, a four and one-half year research and development project undertaken by the Universities of Nottingham, Leicester, and Exeter (Great Britain) and funded by the Department of Education and Science. This project involved observation of over 1,000 lessons and…

  9. Roswell Park-led study finds most cancer research trials do not assess participants’ tobacco use

    Cancer.gov

    While tobacco use can significantly hamper cancer treatment, few cancer researchers are incorporating tobacco assessment into their clinical studies. That’s the conclusion a group of investigators led by researchers at Roswell Park Cancer Institute drew from a recent survey of cancer clinical trials.

  10. Statement Summarizing Research Findings on the Issue of the Relationship Between Food-Additive-Free Diets and Hyperkinesis in Children.

    ERIC Educational Resources Information Center

    Lipton, Morris; Wender, Esther

    The National Advisory Committee on Hyperkinesis and Food Additives paper summarized some research findings on the issue of the relationship between food-additive-free diets and hyperkinesis in children. Based on several challenge studies, it is concluded that the evidence generally refutes Dr. B. F. Feingold's claim that artificial colorings in…

  11. Research Interests: Outside of life (plants and animals) I find process plasmas to be the most complex and

    E-print Network

    Goeckner, Matthew

    of the processes. For example an inductively coupled etch plasma using Cl2 as the feed gas is clearly different. In addition, I have developed two novel plasma sources in which I can readily change plasma heating (sourceResearch Interests: Outside of life (plants and animals) I find process plasmas to be the most

  12. UTSW researchers find that inherited mutated gene raises lung cancer risk for women, those who never smoked

    Cancer.gov

    People who have an inherited mutation of a certain gene have a high chance of getting lung cancer — higher, even, than heavy smokers with or without the inherited mutation, according to new findings by cancer researchers at UT Southwestern Medical Center.

  13. The validity and utility of selection methods in personnel psychology: Practical and theoretical implications of 85 years of research findings

    Microsoft Academic Search

    Frank L. Schmidt; John E. Hunter

    1998-01-01

    This article summarizes the practical and theoretical implications of 85 years of research in personnel selection. On the basis of meta-analytic findings, this article presents the validity of 19 selection procedures for predicting job performance and training performance and the validity of paired combinations of general mental ability (GMA) and Ihe 18 other selection procedures. Overall, the 3 combinations with

  14. Finding Context: What Today's College Students Say about Conducting Research in the Digital Age. Project Information Literacy Progress Report

    ERIC Educational Resources Information Center

    Head, Alison J.; Eisenberg, Michael B.

    2009-01-01

    A report of preliminary findings and analysis from student discussion groups held on 7 U.S. campuses in Fall 2008, as part of Project Information Literacy. Qualitative data from discussions with higher education students across the country suggest that conducting research is particularly challenging. Students' greatest challenges are related to…

  15. Research settings in industrial and organizational psychology: Are findings in the field more generalizable than in the laboratory?

    Microsoft Academic Search

    Robert L. Dipboye; Michael F. Flanagan

    1979-01-01

    The authors analyzed for content all the empirical articles from the 1966, 1970, and 1974 volumes of the Journal of Applied Psychology, Organizational Behavior and Human Performance, and Personnel Psychology to determine the types of organizations, Ss, and dependent measures studied. Contrary to the common belief that field settings provide for more generalization of research findings than laboratory settings do,

  16. UC Davis researchers find oropharyngeal cancer patients with HPV have a more robust response to radiation therapy

    Cancer.gov

    UC Davis cancer researchers have discovered significant differences in radiation-therapy response among patients with oropharyngeal cancer depending on whether they carry the human papillomavirus (HPV), a common sexually transmitted virus. The findings, published online today in The Laryngoscope Journal, could lead to more individualized radiation treatment regimens, which for many patients with HPV could be shorter and potentially less toxic.

  17. Bonus Awards for Teachers in Texas' Performance Pay Program: Findings from the First Round of TEEG Schools. Research Brief

    ERIC Educational Resources Information Center

    National Center on Performance Incentives, 2009

    2009-01-01

    A recent report published by the National Center on Performance Incentives (NCPI) presents findings from the second-year of a multi-year evaluation of the Texas Educator Excellence Grant (TEEG) program, a statewide educator incentive program that operated in Texas. As part of this evaluation report, researchers examined how first-year TEEG schools…

  18. UCSF researchers find that a sugary coating on cells may drive aggressive cancers

    Cancer.gov

    A research team led by UC San Francisco scientists has shown that cancer-induced structural changes in a sugary coating ensheathing cells can promote mechanical interactions that fuel tumor growth and metastasis.

  19. UCLA researchers find that lens-free microscope can detect cancer at the cellular level

    Cancer.gov

    UCLA researchers have developed a lens-free microscope that can be used to detect the presence of cancer or other cell-level abnormalities with the same accuracy as larger and more expensive optical microscopes.

  20. U of Pittsburgh researchers potentially find a better way to track emerging cell therapies using MRIs

    Cancer.gov

    Researchers describe the first human tests of using a perfluorocarbon (PFC) tracer in combination with non-invasive magnetic resonance imaging (MRI) to track therapeutic immune cells injected into patients with colorectal cancer.

  1. Duke researchers find that combining treatments boosts some smokers’ ability to quit

    Cancer.gov

    Combining two smoking cessation therapies is more effective than using just one for male and highly nicotine-dependent smokers who weren't initially helped by the nicotine patch, according to researchers at Duke Medicine.

  2. MIT researchers find new evidence for how a rare form of liver cancer arises

    Cancer.gov

    Using new sequencing technology that enables large-scale analysis of DNA damage-associated mutations, MIT researchers have pinpointed the specific type of DNA damage that may be responsible for this mutation.

  3. Dana-Farber researchers find that marker may predict response to ipilimumab in advanced melanoma

    Cancer.gov

    Dana-Farber researchers found that in patients with advanced melanoma using the immunotherapy ipilimumab, presence of higher levels of the protein VEGF in the blood was associated with a poorer response.

  4. Duke researchers find that new immune therapy successfully treats brain tumors in mice

    Cancer.gov

    Using an artificial protein that stimulates the body's natural immune system to fight cancer, a research team at Duke Medicine has engineered a lethal weapon that kills brain tumors in mice while sparing other tissue.

  5. Duke researchers find that older breast cancer patients still get radiation despite limited benefit

    Cancer.gov

    Women over the age of 70 who have certain early-stage breast cancers overwhelmingly receive radiation therapy despite published evidence that the treatment has limited benefit, researchers at Duke Medicine report.

  6. UCLA researchers develop new screening system to find brain cancer stem cell killers:

    Cancer.gov

    Researchers with UCLA’s Jonsson Comprehensive Cancer Center have developed and used a high-throughput molecular screening approach that identifies and characterizes chemical compounds that can target the stem cells that are responsible for creating deadly brain tumors.

  7. Albert Einstein researchers find that a chemical stem cell signature predicts treatment response for AML

    Cancer.gov

    Researchers at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center have found a chemical “signature” in blood-forming stem cells that predicts whether patients with acute myeloid leukemia will respond to chemotherapy.

  8. Columbia University researchers find that Blacks and Hispanics are at higher risk for precancerous colorectal polyps

    Cancer.gov

    Blacks and Hispanics have a significantly higher risk of developing precancerous colorectal polyps compared with whites, according to a study by researchers at New York Presbyterian Hospital/Columbia University Medical Center.

  9. PRELIMINARY FINDINGS FROM THE DETROIT EXPOSURE AND AEROSOL RESEARCH STUDY (DEARS)

    EPA Science Inventory

    The Detroit Exposure and Aerosol Research Study (DEARS) has completed its first monitoring season (summer 2005) and is progressing toward initiation of its second season (February 2005). The assistance obtained from the Michigan Department of Environmental Quality has been instr...

  10. UC Davis research finds newer radiation therapy technology improves patients' quality of life:

    Cancer.gov

    Patients with head and neck cancers who have been treated with newer, more sophisticated radiation therapy technology enjoy a better quality of life than those treated with older radiation therapy equipment, a study by UC Davis researchers has found.

  11. Hopkins researchers find that a new cancer-fighting strategy would harden cells to prevent metastasis

    Cancer.gov

    Existing cancer therapies are geared toward massacring tumor cells, but Johns Hopkins researchers propose a different strategy: subtly hardening cancer cells to prevent them from invading new areas of the body.

  12. UTHSC researchers find that improved screening means new targets for pediatric neuroblastoma therapies

    Cancer.gov

    A researcher at the University of Texas Health Science Center at San Antonio unveils the important role of microRNAs in regulating neuroblastoma development, pointing to new therapeutic possibilities.

  13. Washington University researchers find key genetic error in family of blood cancers:

    Cancer.gov

    Researchers used whole-genome sequencing to identify a critical mutation in some patients with myelodysplastic syndromes that appears to increase the likelihood they will develop acute myeloid leukemia.

  14. UCLA researchers find intestinal bacteria are linked to white blood cell cancer

    Cancer.gov

    Researchers from UCLA's Jonsson Comprehensive Cancer Center have discovered that specific types of bacteria that live in the gut are major contributors to lymphoma, a cancer of the white blood cells that are part of the human immune system.

  15. Harvard and Baylor researchers find new target for aggressive cancer gene:

    Cancer.gov

    Researchers have found a way to kill human cells hijacked by a genetic accelerator that puts cancer cells into overdrive: the Myc oncogene. The discovery reveals new drug targets for Myc-driven cancers, which tend to be particularly aggressive.

  16. Moffitt researchers find potential new therapeutic target for treating non-small cell lung cancer

    Cancer.gov

    Researchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer. It is based on the newly identified oncogene IKBKE, which helps regulate immune response.

  17. Hopkins researchers find that injected bacteria can shrink tumors in rats, dogs and humans

    Cancer.gov

    A modified version of the Clostridium novyi bacterium can produce a strong and precisely targeted anti-tumor response in rats, dogs and now humans, according to a new report from Johns Hopkins Kimmel Cancer Center researchers.

  18. UNC researchers find that P Rex-1 protein is key to melanoma metastasis:

    Cancer.gov

    Researchers from UNC Lineberger Comprehensive Cancer Center are part of a team that has identified a protein, called P-Rex1, that is key to the movement of cells called melanoblasts. When these cells experience uncontrolled growth, melanoma develops.

  19. UPenn researchers find radiation plus hormone therapy prolongs survival for older men with prostate cancer

    Cancer.gov

    Adding radiation treatment to hormone therapy saves more lives among older men with locally advanced prostate therapy than hormone therapy alone, according to a new study in the Journal of Clinical Oncology this week from Penn Medicine researchers.

  20. Hunstman researchers find that a rare cancer exposes possible route to new treatments

    Cancer.gov

    Researchers from Huntsman Cancer Institute at the University of Utah discovered the unusual role of lactate in the metabolism of alveolar soft part sarcoma, a rare, aggressive cancer that primarily affects adolescents and young adults.

  1. Duke researchers find that prostate cancer’s penchant for copper may be a fatal flaw

    Cancer.gov

    Researchers at Duke Medicine have found a way to kill prostate cancer cells by delivering a trove of copper along with a drug that selectively destroys the diseased cells brimming with the mineral, leaving non-cancer cells healthy.

  2. Columbia U researchers find that generic medications boost adherence to breast cancer therapy

    Cancer.gov

    A study by Columbia University Medical Center researchers has found that the introduction of generic aromatase inhibitors, which are considerably less expensive than their brand-name counterparts, increased treatment adherence by 50 percent.

  3. UCSD researchers find that anti-psychotic medications offer new hope in the battle against glioblastoma

    Cancer.gov

    Researchers at the University of California, San Diego School of Medicine have discovered that FDA-approved anti-psychotic drugs possess tumor-killing activity against the most aggressive form of primary brain cancer, glioblastoma.

  4. Hopkins researchers find that a vaccine can reprogram pancreatic cancers to respond to immunotherapy

    Cancer.gov

    Researchers at the Johns Hopkins Kimmel Cancer Center have developed and tested a vaccine that triggered the growth of immune cell nodules within pancreatic tumors, essentially reprogramming these intractable cancers and potentially making them vulnerable to immune-based therapies.

  5. Emerging Answers: Research Findings on Programs to Reduce Teen Pregnancy (Summary)

    NSDL National Science Digital Library

    Kirby, Douglas

    2001-01-01

    Released on May 30, 2001, by the National Campaign to Prevent Teen Pregnancy, this new report by Dr. Douglas Kirby reviews some 250 studies on teen pregnancy programs. The review finds that long-term programs have made a genuine difference in teen pregnancy, abortion, and birth rates, the last of which is now at its lowest level recorded. Kirby's study also finds no evidence that "abstinence-only" programs are effective or that sex education that covers contraception increases sexual activity. At the site, visitors may download a 21-page summary of the report, the press release, a FAQ, and related information.

  6. Understanding the jigsaw of evidence-based dentistry. 3. Implementation of research findings in clinical practice

    Microsoft Academic Search

    Nigel Pitts

    2004-01-01

    Part one1 of this three-part series provided an overview of evidence-based dentistry (EBD), provided one definition of EBD and, having introduced the EBD matrix, concentrated on the research synthesis part of the jigsaw puzzle. Part two2 focused on the middle row of this puzzle, the dissemination of research results. This final article deals with perhaps the most vital but the

  7. Research-informed evidence and support for road safety legislation: findings from a national survey.

    PubMed

    Smith, Katherine Clegg; Debinski, Beata; Pollack, Keshia; Vernick, Jon; Bowman, Stephen; Samuels, Alicia; Gielen, Andrea

    2014-12-01

    Public opinion is influential in the policymaking process, making it important to understand the factors that influence popular support or opposition to public health policies. Researchers and policymakers tend to agree that scientific evidence can inform decision-making, but this influence has not been explored sufficiently, especially in the area of injury prevention. This paper considers the potential for the communication of evidence-based research and public health data to influence opinion about legislation that could reduce road-related injury. We conducted a nationally-representative online survey to assess public attitudes toward four road-safety laws; ignition interlock, school zone red-light cameras, restrictions on infotainment systems, and children's bicycle helmets. For each law, we assessed initial support and then provided a research-informed statistic on either the injury risk posed or the law's efficacy reducing risk and re-examined the law's support or opposition. The survey was completed by 2397 U.S. adults. Each law was initially supported by a majority of respondents, with greatest support for ignition interlock (74.4%) and children's bicycle helmets (74.8%). Exposure to research-informed statements increased legislative support for 20-30% of respondents. Paired analyses demonstrate significant increases toward supportive opinions when comparing responses to the initial and research-informed statements. The study demonstrates considerable public support for evidence-based road-related laws. Overall support was augmented by exposure to research data. Injury prevention practitioners can capitalize on this support in efforts to build support for legislation that would prevent injury. Researchers should be encouraged to expand their efforts to share research results with both the public and policymakers. PMID:25215926

  8. Overview of findings from the World Trade Center Disaster Outcome Study: recommendations for future research after exposure to psychological trauma.

    PubMed

    Boscarino, Joseph A; Adams, Richard E

    2008-01-01

    In this article we review findings from the World Trade Center Disaster (WTCD) Outcomes Study, a prospective cohort study of 2,368 New York City (NYC) adults funded by the National Institutes of Health after the September 11 attacks. The findings reported were based on a baseline survey conducted one year after the disaster and a follow-up conducted two years post-disaster. One of the goals of this research was to assess the effectiveness of post-disaster treatments received by NYC residents following the attacks. Among the major findings of this study were the relatively small increase in mental health service utilization and the fact that only brief worksite interventions seemed to be an effective post-disaster treatment intervention. Specifically, those who received more conventional post-disaster interventions, such as formal psychotherapy sessions and/or psychotropic medicines, seemed to have poorer outcomes. Since this study was designed to assess treatment outcomes, use advanced measurement techniques, and incorporate propensity score matching to control for bias, these treatment findings were unexpected and raised clinical questions. Additional findings were also discussed related to minority group members, alcohol abuse, the onset and course of posttraumatic stress disorder post-disaster and other findings. Future research is recommended to resolve the issues raised by this important study, especially as this relates to treatment outcomes. PMID:19278144

  9. Conclusions: Overview of Findings from the ERA Study, Inferences, and Research Implications

    ERIC Educational Resources Information Center

    Rutter, Michael; Sonuga-Barke, Edmund J.

    2010-01-01

    In this monograph, the authors have brought the findings of the English and Romanian Adoptee (ERA) study up to age 15 years and, in so doing, have focused especially on the question of whether there are deprivation-specific psychological patterns (DSPs) that differ meaningfully from other forms of psychopathology. For this purpose, their main…

  10. 76 FR 33763 - Findings of Misconduct in Science/Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-09

    ...by falsely labeling lane 5 to represent papain digestion of the [alpha]VBS peptide, and by falsely inserting a band in lane 3 to represent the [alpha]VBS peptide. ORI issued a charge letter enumerating the above findings of misconduct...

  11. Peer and neighbourhood influences on teenage pregnancy and fertility: Qualitative findings from research in English communities

    Microsoft Academic Search

    Lisa Arai

    Geographic variation in teenage pregnancy is attributable to social and cultural, as well as demographic, factors. In some communities and social networks early childbearing may be acceptable, or even normative. It is these places that are the focus of policy initiatives. This paper reports the findings of a qualitative study of neighbourhood and peer influences on the transition from pregnancy

  12. Fox Chase researchers find that most Medicare patients wait weeks before breast cancer surgery

    Cancer.gov

    Although patients may feel anxious waiting weeks from the time of their first doctor visit to evaluate their breast until they have breast cancer surgery, new findings from Fox Chase Cancer Center show that these waits are typical in the United States. Results were published on Monday, November 19 in the Journal of Clinical Oncology.

  13. The Contributions of Culture and Ethnicity To New Zealand Mental Health Research Findings

    Microsoft Academic Search

    Rees Tapsell; Graham Mellsop

    2007-01-01

    Background & material: In the last five years a number of studies have been conducted in specialist psychiatric and primary care populations in New Zealand which have allowed comparisons in terms of clinical phenomena and therapeutic experiences between Mâori (the indigenous people of New Zealand) and non-Mâori. These studies were reviewed in terms of the methodology used, their major findings

  14. Informed Consent for Exome Sequencing Research in Families with Genetic Disease: The Emerging Issue of Incidental Findings

    PubMed Central

    Bergner, Amanda L.; Bollinger, Juli; Raraigh, Karen S.; Tichnell, Crystal; Murray, Brittney; Blout, Carrie Lynn; Telegrafi, Aida Bytyci; James, Cynthia A.

    2015-01-01

    Genomic sequencing technology is increasingly used in genetic research. Studies of informed consent for exome and genome sequencing (ES/GS) research have largely involved hypothetical scenarios or healthy individuals enrolling in population-based studies. Studies have yet to explore the consent experiences of adults with inherited disease. We conducted a qualitative interview study of 15 adults recently enrolled in a large-scale ES/GS study (11 affected adults, four parents of affected children). Our study had two goals: (1) to explore three theoretical barriers to consent for ES/GS research (interpretive/technical complexity, possibility of incidental findings, and risks of loss of privacy); and (2) to explore how interviewees experienced the consent process. Interviewees could articulate study goals and processes, describe incidental findings, discuss risks of privacy loss, and reflect on their consent experience. Few expected the study would identify the genetic cause of their condition. All elected to receive incidental findings. Interviewees acknowledged paying little attention to potential implications of incidental findings in light of more pressing goals of supporting research regarding their own medical conditions. Interviewees suggested that experience living with a genetic condition prepared them to adjust to incidental findings. Interviewees also expressed little concern about loss of confidentiality of study data. Some experienced the consent process as very long. None desired reconsent prior to return of study results. Families with inherited disease likely would benefit from a consent process in which study risks and benefits were discussed in the context of prior experiences with genetic research and genetic disease. PMID:25251809

  15. Extraversion and Vigilance Performance: 30 Years of Inconsistencies

    Microsoft Academic Search

    Harry S. Koelega

    1992-01-01

    Deteriorating efficiency in detecting critical events is a pervasive phenomenon. It has been asserted that the personality dimension of extraversion–introversion (E-I) could serve as a selection device: Introverts would be superior in sustained attention. A meta-analysis revealed better performance of introverts, but the effect size was small because of a high incidence of inconsistencies. In a subset of the studies,

  16. Steps to Strengthen Ethics in Organizations: Research Findings, Ethics Placebos, and What Works

    PubMed Central

    Pope, Kenneth S.

    2015-01-01

    Research shows that many organizations overlook needs and opportunities to strengthen ethics. Barriers can make it hard to see the need for stronger ethics and even harder to take effective action. These barriers include the organization’s misleading use of language, misuse of an ethics code, culture of silence, strategies of justification, institutional betrayal, and ethical fallacies. Ethics placebos tend to take the place of steps to see, solve, and prevent problems. This article reviews relevant research and specific steps that create change. PMID:25602131

  17. Steps to strengthen ethics in organizations: research findings, ethics placebos, and what works.

    PubMed

    Pope, Kenneth S

    2015-01-01

    Research shows that many organizations overlook needs and opportunities to strengthen ethics. Barriers can make it hard to see the need for stronger ethics and even harder to take effective action. These barriers include the organization's misleading use of language, misuse of an ethics code, culture of silence, strategies of justification, institutional betrayal, and ethical fallacies. Ethics placebos tend to take the place of steps to see, solve, and prevent problems. This article reviews relevant research and specific steps that create change. PMID:25602131

  18. Finding Semantic Inconsistencies in UMLS using Answer Set Programming Halit Erdogan

    E-print Network

    Erdem, Esra

    - onymy, wrong categorization, ambiguity and so forth. For example, Capsule of adrenal gland, it is defined as a subclass of Capsule. Once integrated in the UMLS, Capsule of adrenal gland appears as a child

  19. What Teacher Characteristics Affect Student Achievement? Findings from Los Angeles Public Schools. Research Brief

    ERIC Educational Resources Information Center

    Giglio, Kate

    2010-01-01

    Teacher effectiveness is typically measured by traditional teacher qualification standards, such as experience, education, and scores on licensure examinations. RAND researchers found no evidence that these standards have a substantial effect on student achievement in Los Angeles public elementary, middle, and high schools. Alternative measures of…

  20. Better Together: Research Findings on the Relationship between Racial Justice Organizations and LGBT Communities. Report

    ERIC Educational Resources Information Center

    Sen, Rinku; Wessler, Seth; Apollon, Dominique

    2010-01-01

    In partnership with the Arcus Foundation, the Applied Research Center (ARC) has undertaken a study of the relationship between racial justice organizations and lesbian/gay/bisexual/transgender (LGBT) constituencies and issues, with the understanding that communities of color themselves, including their LGBT members, have a good deal at stake in…

  1. Linking Lessons learnt from the Classroom with Research Findings on Pedagogies with GIS

    Microsoft Academic Search

    Mary Fargher

    When used effectively, GIS are powerful purveyors of information where maps, photographs, satellite images and other spatial data can be generated together. However, this potential is yet to be fully recognised in geography education in UK schools. The associated challenges with implementing such technologies are not unique to GIS. In this paper, research evidence suggesting connections between successful implementation of

  2. Georgetown researchers find that landmark Medicare law had little impact on reducing chemotherapy cost

    Cancer.gov

    Legislation passed in 2003 to slow the spiraling costs of drugs paid for by the federal government to treat Medicare patients has had no meaningful impact on cancer chemotherapy drug costs, say a team of researchers in the Journal of Clinical Oncology published online today.

  3. Jefferson researchers find that cancer information on Wikipedia is accurate, but not very readable:

    Cancer.gov

    It is a commonly held that information on Wikipedia should not be trusted, since it is written and edited by non-experts without professional oversight. But researchers from the Kimmel Cancer Center at Jefferson have found differently, according to a study published online Sept. 15 in the Journal of Oncology Practice.

  4. Stress, Coping and Burnout in Mental Health Nurses: Findings From Three Research Studies

    Microsoft Academic Search

    Leonard Fagin; Jerome Carson; John Leary; Nicolette De Villiers; Heather Bartlett; Patty OMalley; Maria West; Stephen Mcelfatrick; Daniel Brown

    1996-01-01

    In this paper we present data from three research studies on stress, coping and burnout in mental health nurses. All three studies used a range of self report questionnaires. Measures included a demographic checklist, the General Health Questionnaire (GHQ-28), the Maslach Burnout Inventory, the DCL Stress Scale and the Cooper Coping Skills Scale. In all, 648 ward based mental health

  5. Standardization in EU Education and Training Policy: Findings from a European Research Network

    ERIC Educational Resources Information Center

    Ertl, Hubert; Phillips, David

    2006-01-01

    This paper describes an EU-funded project under the Training and Mobility of Researchers (TMR) Programme, with a particular emphasis on the Oxford-based part. Involving six European universities, the overarching investigation was concerned with the tensions between standardization and tradition in education. In Oxford the focus was on aspects of…

  6. Washington University researchers find that mass prostate cancer screenings don’t reduce death:

    Cancer.gov

    There’s new evidence that annual prostate cancer screening does not reduce deaths from the disease, even among men in their 50s and 60s and those with underlying health conditions, according to new research led by Washington University School of Medicine in St. Louis.

  7. Georgetown researchers examine nipple sparing mastectomy cases and find no recurrent or new cancers:

    Cancer.gov

    A new study suggests some women needing a lumpectomy or mastectomy to treat their breast cancer have another potential option that is safe and effective, say researchers at Georgetown. They say the procedure known as a nipple sparing mastectomy is also a viable surgical option for women who choose to have their breasts removed because of their increased risk of developing the disease.

  8. Requirements Engineering as Creative Problem Solving: A Research Agenda for Idea Finding

    Microsoft Academic Search

    Neil A. M. Maiden; Sara Jones; Inger Kristine Karlsen; Roger Neill; Konstantinos Zachos; Alastair Milne

    2010-01-01

    This vision paper frames requirements engineering as a creative problem solving process. Its purpose is to enable requirements researchers and practitioners to recruit relevant theories, models, techniques and tools from creative problem solving to understand and support requirements processes more effectively. It uses 4 drivers to motivate the case for requirements engineering as a creative problem solving process. It then

  9. A Visitor's Guide to Effect Sizes – Statistical Significance Versus Practical (Clinical) Importance of Research Findings

    Microsoft Academic Search

    Mohammadreza Hojat; Gang Xu

    2004-01-01

    Effect Sizes (ES) are an increasingly important index used toquantify the degree of practical significanceof study results. This paper gives anintroduction to the computation andinterpretation of effect sizes from theperspective of the consumer of the researchliterature. The key points made are:1. ES is a useful indicator of the practical(clinical) importance of research resultsthat can be operationally defined frombeing ``negligible'' to

  10. A Visitor's Guide to Effect Sizes--Statistical Significance versus Practical (Clinical) Importance of Research Findings

    ERIC Educational Resources Information Center

    Hojat, Mohammadreza; Xu, Gang

    2004-01-01

    Effect Sizes (ES) are an increasingly important index used to quantify the degree of practical significance of study results. This paper gives an introduction to the computation and interpretation of effect sizes from the perspective of the consumer of the research literature. The key points made are: (1) "ES" is a useful indicator of the…

  11. The ABCs of Keeping on Track to Graduation: Research Findings from Baltimore

    ERIC Educational Resources Information Center

    Mac Iver, Martha Abele; Messel, Matthew

    2013-01-01

    This study of graduation outcomes in Baltimore uses multivariate analysis of longitudinal student cohort data to examine the impact of factors identified in previous research as early warning indicators of a dropout outcome. Student cohort files were constructed from longitudinal administrative data (following all first-time 2004-2005 and…

  12. University of Washington researchers find community effort brings lasting drop in smoking, delinquency, drug use:

    Cancer.gov

    Tenth graders in towns using Communities That Care [a prevention system developed by University of Washington researchers] were less likely to have tried drinking or smoking compared with teens living in towns that had not adopted the system. Delinquent behavior, including stealing, vandalism and physical fights, decreased too.

  13. The Meaning of Work among Chinese University Students: Findings from Prototype Research Methodology

    ERIC Educational Resources Information Center

    Zhou, Sili; Leung, S. Alvin; Li, Xu

    2012-01-01

    This study examined Chinese university students' conceptualization of the meaning of work. One hundred and ninety students (93 male, 97 female) from Beijing, China, participated in the study. Prototype research methodology (J. Li, 2001) was used to explore the meaning of work and the associations among the identified meanings. Cluster analysis was…

  14. NASA Research Focuses on Yellowstone's Hot Springs and Compares Findings to Rocks from Mars

    NSDL National Science Digital Library

    Yellowstone Park Foundation

    This NASA Astrobiology Institute website features an article by the Yellowstone Park Foundation focusing on NASA's latest thermophile research and its contributions to outreach education in Yellowstone National Park. The site also provides a number of useful links through the NAI portal site including a teacher's page, student's page, and additional NAI articles and newsletters.

  15. Social and Emotional Distress among American Indian and Alaska Native Students: Research Findings. ERIC Digest.

    ERIC Educational Resources Information Center

    Clarke, Ardy SixKiller

    Many American Indian and Alaska Native (AI/AN) youth are repeatedly exposed to opportunities to participate in self-destructive and illegal behaviors. This digest examines risk factors associated with four contexts: peers, family, school, and community. Recent research has shown that, relative to national averages, AI/AN youth have higher rates of…

  16. University of Wisconsin researchers find a new form of cell division

    Cancer.gov

    Researchers at the University of Wisconsin Carbone Cancer Center have discovered a new form of cell division in human cells. They believe it serves as a natural back-up mechanism during faulty cell division, preventing some cells from going down a path that can lead to cancer.

  17. Northwestern researchers find lower dosage CT-guided lung biopsy protocol maintains quality, minimizes exposure

    Cancer.gov

    New guidelines for CT-guided biopsies of lung nodules significantly reduce radiation exposure allowing individuals the benefit of the procedure, which may cut down on overall lung cancer deaths. This research is being presented at the Society of Interventional Radiology's 37th Annual Scientific Meeting in San Francisco, Calif.

  18. Penn researchers find Epstein Barr-like virus infects and may cause cancer in dogs

    Cancer.gov

    ...A team of researchers from the University of Pennsylvania School of Veterinary Medicine and Penn's Perelman School of Medicine has the first evidence that an Epstein Barr-like virus can infect and may also be responsible for causing lymphomas in man's best friend.

  19. Penn researchers find genetically modified T cells cause sustained remissions in patients with chronic lymphocytic leukemia:

    Cancer.gov

    Researchers from the University of Pennsylvania's Abramson Cancer Center and Perelman School of Medicine have shown sustained remissions of up to a year among a small group of advanced chronic lymphocytic leukemia (CLL) patients treated with genetically engineered versions of their own T cells.

  20. Key Events and Lessons for Managers in a Diverse Workforce: A Report on Research and Findings.

    ERIC Educational Resources Information Center

    Douglas, Christina A.

    The research documented in this report builds on earlier work in the 1980s in the area of on-the-job experiences in developing effective leaders. The current study was designed to answer the following: (1) What are the significant events from which African American managers learn and develop? (2) Are the key events and lessons learned different…

  1. Published: 24 hours ago New research finds people and pigeons see eye to eye

    E-print Network

    Gosselin, Frédéric

    get a leg up from evolution, which has been developing "programs" for object recognition in animals studies animal behavior, details his latest research in the journal article, "Non-accidental properties advances, such as small visual prosthetics for the visually impaired, in the same way that understanding

  2. Respite care for Alzheimer's families: Research findings and their relevance to providers

    Microsoft Academic Search

    M. Powell Lawton; Elaine Brody; Avalie Saperstein

    1989-01-01

    A research project to evaluate a respite care program for caregivers of patients with Alzheimer's disease and related conditions provided information relevant to service providers of respite care. Providers must under-stand the psychological needs of caregivers that enter into their willingness to use respite care. Caregiving equity, caregiving modeling, the moral imperative of caregiving, caregiving as a challenge, caregiving as

  3. Fox Chase researchers find that targeted therapy extends progression-free survival for advanced ovarian cancer:

    Cancer.gov

    A new Phase 3 clinical trial conducted by the Gynecologic Oncology Group showed that a targeted therapy called bevacizumab (Avastin) effectively delayed the progression of advanced ovarian cancer. Patients with newly diagnosed advanced ovarian cancer now typically undergo surgery and chemotherapy, but the new research suggests an additional avenue of treatment.

  4. Designing for Dissemination Among Public Health Researchers: Findings From a National Survey in the United States

    PubMed Central

    Jacobs, Julie A.; Tabak, Rachel G.; Hoehner, Christine M.; Stamatakis, Katherine A.

    2013-01-01

    Objectives. We have described the practice of designing for dissemination among researchers in the United States with the intent of identifying gaps and areas for improvement. Methods. In 2012, we conducted a cross-sectional study of 266 researchers using a search of the top 12 public health journals in PubMed and lists available from government-sponsored research. The sample involved scientists at universities, the National Institutes of Health, and the Centers for Disease Control and Prevention in the United States. Results. In the pooled sample, 73% of respondents estimated they spent less than 10% of their time on dissemination. About half of respondents (53%) had a person or team in their unit dedicated to dissemination. Seventeen percent of all respondents used a framework or theory to plan their dissemination activities. One third of respondents (34%) always or usually involved stakeholders in the research process. Conclusions. The current data and the existing literature suggest considerable room for improvement in designing for dissemination. PMID:23865659

  5. Penn researchers find contralateral prophylactic mastectomy offers limited gains to life expectancy for breast cancer patients:

    Cancer.gov

    Contralateral prophylactic mastectomy (CPM), a procedure that removes the unaffected breast in patients with cancer in one breast, provides only a modest increase in life expectancy, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania.

  6. Socioeconomic Status and the Undergraduate Engineering Experience: Preliminary Findings from Four American Universities. Research Brief

    ERIC Educational Resources Information Center

    Donaldson, Krista; Lichtenstein, Gary; Sheppard, Sheri

    2008-01-01

    Students of lower socioeconomic status (SES) tend to be underrepresented in American higher education, particularly at four-year institutions and more selective universities. Education researchers have shown that in the four year period following high school, low SES students are less likely to persist to a bachelor's degree or have graduate…

  7. UCSD researchers find that tumor suppressor mutations alone don't explain deadly cancer

    Cancer.gov

    Although mutations in a gene dubbed 'the guardian of the genome' are widely recognized as being associated with more aggressive forms of cancer, researchers have found evidence suggesting that the deleterious health effects of the mutated gene may in large part be due to other genetic abnormalities, at least in squamous cell head and neck cancers.

  8. Hopkins researchers find that blood test for 'nicked' protein predicts prostate cancer treatment response

    Cancer.gov

    Prostate cancer patients whose tumors contain a shortened protein called AR-V7, which can be detected in the blood, are less likely to respond to two widely used drugs for metastatic prostate cancer, according to results of a study led by researchers at the Johns Hopkins Kimmel Cancer Center.

  9. Can We Find Solutions with People? Participatory Action Research with Small Organic Producers in Andalusia

    ERIC Educational Resources Information Center

    Cuellar-Padilla, Mamen; Calle-Collado, Angel

    2011-01-01

    This paper reports on an experiment linking science with people. Taking as a paradigm the holistic scientific approach fostered by agroecology, we present a methodological proposal for the implementation of participatory action research in rural areas. Our aims were various: to solve a specific problem, i.e. the exclusion of small- and…

  10. Understanding resistance to sex and race-based affirmative action: A review of research findings

    Microsoft Academic Search

    Kelli Cook

    1995-01-01

    The public discussion of affirmative action appears to be complicated by disagreements regarding definitions and by the lack of a theoretical framework from which to begin to understand this complex public policy. The present review attempts to synthesize the available research into a model from which resistance to affirmative action can be understood. Within the model, resistance to affirmative action

  11. UCSF researchers find that longer telomeres could be linked to risk of brain cancer

    Cancer.gov

    New genomic research led by UC San Francisco scientists reveals that two common gene variants that lead to longer telomeres, the caps on chromosome ends thought by many scientists to confer health by protecting cells from aging, also significantly increase the risk of developing the deadly brain cancers known as gliomas.

  12. MD Anderson researchers find that chemotherapy is as effective before breast cancer surgery as after

    Cancer.gov

    Whether chemotherapy is given before or after breast-conserving therapy does not have an impact on long-term local-regional outcomes, suggesting treatment success is due more to biologic factors than chemotherapy timing, according to a study by researchers at The University of Texas MD Anderson Cancer Center.

  13. The importance of the repressive coping style: findings from 30 years of research

    Microsoft Academic Search

    Lynn B. Myers

    2010-01-01

    During the last three decades there has been substantial research exploring the repressive coping style as defined by Weinberger, Schwartz, and Davidson. As “repressors,” who score low on trait anxiety and high on defensiveness, account for up to 50% of certain populations, they are an essential group for psychologists to study. However, there are methodological issues in identifying repressors as

  14. The Challenge of Finding Faculty Time for Applied Research Activities in Ontario Colleges

    ERIC Educational Resources Information Center

    Rosenkrantz, Otte

    2013-01-01

    The purpose of this study was to explore how the role of Ontario college faculty has evolved since the advent of the Post-Secondary Education Choice and Excellence Act of 2000 and the Colleges of Applied Arts and Technology Act of 2002 in terms of whether or not the decision to create a research culture at the colleges included making time…

  15. Georgetown researchers find higher estrogen production in the breast could confer greater cancer risk than thought:

    Cancer.gov

    Could some women who naturally produce excess aromatase in their breasts have an increased risk of developing breast cancer? Results of a new animal study suggests that may be the case, say researchers at Georgetown Lombardi Comprehensive Cancer Center, a part of Georgetown University Medical Center.

  16. U of Michigan researchers find that new sequencing technique reveals genetic clues to rare breast tumors

    Cancer.gov

    A new study from researchers at the University of Michigan Comprehensive Cancer Center characterizes the genetic underpinnings of a rare type of breast tumor called phyllodes tumors, offering the first comprehensive analysis of the molecular alterations at work in these tumors.

  17. Research Findings on Neurolinguistic Programming: Nonsupportive Data or an Untestable Theory?

    Microsoft Academic Search

    Christopher F. Sharpley

    1987-01-01

    In an earlier review of the experimental literature on neurolinguistic programming (NLP), Sharpley (1984) drew the conclusion that the effectiveness of this therapy was yet to be demonstrated. In their comment on that review, Einspruch and Forman (1985) agreed with this conclusion but suggested that it was due to the presence of methodological errors in the research on NLP to

  18. Finding the Right Path: Researching Your Way to Discovery. Professional Growth Series.

    ERIC Educational Resources Information Center

    Sutter, Lynne; Sutter, Herman

    Intended for use by teachers, librarians, parents, and elementary school students, this book provides 115 pathfinders to a variety of subjects to guide a student's research and broaden a child's interest base. Each pathfinder (i.e., collection of resources on a given topic) includes: a description of the subject; the Dewey Decimal numbers specific…

  19. Kimmel Cancer Center researchers find drugs targeting chromosomal instability may fight a particular breast cancer subtype

    Cancer.gov

    A team of researchers at Jefferson's Kimmel Cancer Center has shown in a study published online Feb. 6 in the Journal of Clinical Investigation that the oncogene cyclin D1 may promote a genetic breakdown known as chromosomal instability (CIN). CIN is a known, yet poorly understood culprit in tumor progression.

  20. Domestic Violence Between Same-Gender Partners: Recent Findings and Future Research

    ERIC Educational Resources Information Center

    McClennen, Joan C.

    2005-01-01

    Empirical literature about same-gender domestic violence was relatively nonexistent until the past 20 years, and conducting research with this population about a sensitive topic remains a daunting endeavor. Existing studies reveal similarities between opposite- and same-gender domestic violence in prevalence, types of abuse, and various dynamics,…

  1. Building the Future Students' Blended Learning Experiences from Current Research Findings

    ERIC Educational Resources Information Center

    Jefferies, Amanda; Hyde, Ruth

    2010-01-01

    Between March 2007 and February 2009, the Joint Information Systems Committee (JISC) funded a Learners Journeys project at the University of Hertfordshire. This was part of their second phase of investment in research into the Learners' Experiences through their E-Learning Programme and was known as LXP2. STROLL (STudent Reflections On Lifelong…

  2. Language of Instruction in Tanzania: Why Are Research Findings Not Heeded?

    ERIC Educational Resources Information Center

    Qorro, Martha A. S.

    2013-01-01

    The issue of language of instruction (LOI) and its effects on education in Tanzanian secondary education has been widely researched since the early 1980s. In 2009, the Ministry of Education and Vocational Training proposed a new education and training policy that allows English to be used as LOI from nursery school to tertiary education. The…

  3. UNC and other researchers find that gene expression improves the definition of a breast cancer subtype

    Cancer.gov

    A study conducted by the Vall d'Hebron Institute of Oncology in conjunction with the GEICAM cooperative group and other American and Canadian researchers, including UNC, has led to a change in the definition of hormone-sensitive breast tumors

  4. Moffitt research finds no survival advantage for stem cell versus bone marrow transplant

    Cancer.gov

    Researchers at Moffitt Cancer Center, and colleagues in the Blood and Marrow Transplant Clinical Trials Network conducted a two-year clinical trial comparing two-year survival probabilities for patients transplanted with peripheral blood stem cells or bone marrow stem cells from unrelated donors and found no survival advantage for one method over the other.

  5. Johns Hopkins researchers find that chronic inflammation is linked to high-grade prostate cancer

    Cancer.gov

    Men who show signs of chronic inflammation in non-cancerous prostate tissue may have nearly twice the risk of actually having prostate cancer than those with no inflammation, according to results of a new study led by researchers from the Johns Hopkins Kimmel Cancer Center.

  6. Implementation of Classroom Research Findings on the Early Language Development of Mentally Handicapped Children

    Microsoft Academic Search

    Roy McConkey; Mary OConnor

    1980-01-01

    Language intervention research with mentally handicapped children has identified techniques of proven effectiveness. However, this information has not been readily available to those professionals in the best position to help the children, namely teachers and their assistants.In an attempt to do this, a series of five video-programmes was made, illustrating assessment and teaching techniques suited to mentally handicapped children at

  7. Census of Institutional Repositories in the United States: MIRACLE Project Research Findings. CLIR Publication No. 140

    ERIC Educational Resources Information Center

    Markey, Karen; Rieh, Soo Young; St. Jean, Beth; Kim, Jihyun; Yakel, Elizabeth

    2007-01-01

    In this report, the authors describe results of a nationwide census of institutional repositories in U.S. academic institutions. The census is one of several activities of the MIRACLE Project, an Institute of Museum and Library Services (IMLS)-funded research program based at the University of Michigan. The acronym MIRACLE means "Making…

  8. Nanotoxicology and nanotechnology: new findings from the NIEHS and Superfund Research Program scientific community.

    PubMed

    Carlin, Danielle J

    2014-01-01

    Nanomaterials are characterized by their small size (i.e., nanometer scale) and can be engineered from nearly any chemical substance, creating materials that differ in composition, particle size, shape, and surface coatings. These materials are often seen as a "double-edged sword" by having properties that make them potentially beneficial in product development, drug delivery, and remediation of hazardous substances, but these same properties may result in interaction with biological systems and potential effects in the environment. The National Institute of Environmental Health Sciences (NIEHS) is interested in both the potential risks associated with exposure to these materials, while harnessing the power of engineered nanomaterials to improve public health. This presentation will consist of discussion of nanoparticle studies by NIEHS researchers and the extramural community and its efforts to develop cross-agency initiatives to solve the many vexing issues associated with nanomaterials. For example, researchers from the NIEHS National Toxicology Program (NTP) are evaluating a number of nanomaterial classes in comprehensive toxicology studies. NIEHS also has an extensive extramural research grant portfolio consisting of the Nano Grand Opportunities (Nano GO) Program and NIEHS Centers for Nanotechnology Health Implications Research (NCNHIR) Consortium consisting of U19 and U01 Cooperative Centers. Furthermore, the NIEHS Superfund Research Program (SRP), which supports a network of university (P42, R01), small business (SBIR/STTR), and training grants (R25), provides funding to grantees evaluating the toxicology of nanomaterials, developing new or improved nanotechnologies to monitor and remediate hazardous substances, and training professionals in the use of these of materials. The NIEHS's Worker Education Branch also offers educational materials for training workers on risks of nanotechnology in laboratories, manufacturing facilities, at hazardous waste cleanup sites, and during emergency responses. In conclusion, this presentation will stimulate dialogue regarding the need for more research on these complex materials and serve as a resource about the wide variety of ongoing studies on nanomaterials at NIEHS that will contribute to the determination of risk associated with this class of compounds. PMID:24695034

  9. Industry sponsorship bias in research findings: a network meta-analysis of LDL cholesterol reduction in randomised trials of statins

    PubMed Central

    Dias, Sofia; Ades, A E

    2014-01-01

    Objective To explore the risk of industry sponsorship bias in a systematically identified set of placebo controlled and active comparator trials of statins. Design Systematic review and network meta-analysis. Eligibility Open label and double blind randomised controlled trials comparing one statin with another at any dose or with control (placebo, diet, or usual care) for adults with, or at risk of developing, cardiovascular disease. Only trials that lasted longer than four weeks with more than 50 participants per trial arm were included. Two investigators assessed study eligibility. Data sources Bibliographic databases and reference lists of relevant articles published between 1 January 1985 and 10 March 2013. Data extraction One investigator extracted data and another confirmed accuracy. Main outcome measure Mean absolute change from baseline concentration of low density lipoprotein (LDL) cholesterol. Data synthesis Study level outcomes from randomised trials were combined using random effects network meta-analyses. Results We included 183 randomised controlled trials of statins, 103 of which were two-armed or multi-armed active comparator trials. When all of the existing randomised evidence was synthesised in network meta-analyses, there were clear differences in the LDL cholesterol lowering effects of individual statins at different doses. In general, higher doses resulted in higher reductions in baseline LDL cholesterol levels. Of a total of 146 industry sponsored trials, 64 were placebo controlled (43.8%). The corresponding number for the non-industry sponsored trials was 16 (43.2%). Of the 35 unique comparisons available in 37 non-industry sponsored trials, 31 were also available in industry sponsored trials. There were no systematic differences in magnitude between the LDL cholesterol lowering effects of individual statins observed in industry sponsored versus non-industry sponsored trials. In industry sponsored trials, the mean change from baseline LDL cholesterol level was on average 1.77 mg/dL (95% credible interval ?11.12 to 7.66) lower than the change observed in non-industry sponsored trials. There was no detectable inconsistency in the evidence network. Conclusions Our analysis shows that the findings obtained from industry sponsored statin trials seem similar in magnitude as those in non-industry sources. There are actual differences in the effectiveness of individual statins at various doses that explain previously observed discrepancies between industry and non-industry sponsored trials. PMID:25281681

  10. Making life easier with effort: Basic findings and applied research on response effort.

    PubMed

    Friman, P C

    1995-01-01

    Early basic research showed that increases in required response effort (or force) produced effects that resembled those produced by punishment. A recent study by Alling and Poling determined some subtle differences between the two behavior-change strategies, but also confirmed that increasing required effort is an effective response-reduction procedure with enduring effects. In this paper we summarize basic research on response effort and explore the role of effort in diverse applied areas including deceleration of aberrant behavior, attention deficit hyperactivity disorder, oral habits, health care appointment keeping, littering, indexes of functional disability, and problem solving. We conclude that renewed interest in response effort as an independent variable is justified because of its potent effects and because the political constraints imposed on punishment- and reinforcement-based procedures have yet to be imposed on procedures that entail manipulations of response effort. PMID:16795886

  11. New Study Finds Increasing Gender Equity at U.S. Research Institutions

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2009-06-01

    Women and men faculty in science, engineering, and mathematics for the most part have comparable opportunities within major U.S. research universities, according to a report released 2 June by the U.S. National Research Council (NRC). The report found that gender does not appear to have been a factor in a number of important career transitions and outcomes, including hiring for tenure track and tenure positions and promotions. “That is probably going to be surprising to many people. It was surprising to our own panel. And it may not have been the case if we had done the study in 1985 instead of 2005,” said Claude Canizares, cochair of the NRC committee that prepared the report, entitled Gender Differences at Critical Transitions in the Careers of Science, Engineering and Mathematics Faculty.

  12. Utility of Genome-Wide Association Study findings: prostate cancer as a translational research paradigm

    PubMed Central

    Turner, Aubrey R.; Kader, A. Karim; Xu, Jianfeng

    2013-01-01

    Genomewide Association Studies (GWAS) have identified thousands of consistently replicated associations between genetic markers and complex disease risk, including cancers. Alone, these markers have limited utility in risk prediction; however, when several of these markers are used in combination, the predictive performance appears to be similar to currently many available clinical predictors. Despite this, there are divergent views regarding the clinical validity and utility of these genetic markers in risk prediction. There are valid concerns, thus providing a direction for new lines of research. Herein, we outline the debate, and use the example of prostate cancer to highlight emerging evidence from studies that aim to address potential concerns. We also describe a translational framework which could be used to guide the development of a new generation of comprehensive research studies aimed at capitalizing on these exciting new discoveries. PMID:22272820

  13. The Impact of the Pill on Implantation Factors—New Research Findings

    Microsoft Academic Search

    John Wilks; B. Pharm; MPS MACPP

    For health consumers and health care professionals of an orthodox Judeo-Christian or Islamic tradition, as w ell as those authentically concerned with the universal respect of unqualified human rights, the asserted capacity of the pill to act as an abortifacient, both in its once-a-day and 'mo rning-after' permutations, is one of significant moral weight. The research on 'break-through' ovulation 1

  14. Stanford University researchers find that dual-action protein better restricts blood vessel formation:

    Cancer.gov

    In a paper published online Aug. 8 in the Proceedings of the National Academy of Sciences, researchers at Stanford University describe the creation of a new type of engineered protein that is significantly more effective at preventing the formation of blood vessels by targeting not one, but two of the chemical receptors that control the creation of new capillaries -- a process known as angiogenesis. The study shows that the new protein blocks both receptors.

  15. Emory University researchers find new pathway for regulation of blood vessel growth in cancer

    Cancer.gov

    Researchers at Winship Cancer Institute of Emory University have identified a new function for a gene that normally prevents the development of cancer. Scientists had known that the gene, which encodes a protein called p14 ARF, works inside the cell to control proliferation and division. The Winship team discovered that p14 ARF also regulates tumor-induced angiogenesis, the process by which growing cancers attract new blood vessels.

  16. UC San Diego researchers find an enzyme that offers new therapeutic target for cancer drugs

    Cancer.gov

    Researchers at the University of California, San Diego School of Medicine have uncovered a new signal transduction pathway specifically devoted to the regulation of alternative RNA splicing, a process that allows a single gene to produce or code multiple types of protein variants. The discovery, published in the June 27, 2012 issue of Molecular Cell, suggests the new pathway might be a fruitful target for new cancer drugs. The University of California, San Diego is home to the Moores Comprehensive Cancer Center.

  17. Hopkins researchers find that cancer cells feed on sugar-free diet:

    Cancer.gov

    Cancer cells have been long known to have a “sweet tooth,” using vast amounts of glucose for energy and for building blocks for cell replication.   Now, a study by a team of researchers at Johns Hopkins and elsewhere shows that lymph gland cancer cells called B cells can use glutamine in the absence of glucose for cell replication and survival, particularly under low-oxygen conditions, which are common in tumors.

  18. Johns Hopkins researchers find key to lymph node metastasis in mice

    Cancer.gov

    In a study reported Sept. 10 in the Proceedings of the National Academy of Sciences Online Early Edition, researchers at Johns Hopkins describe their discovery of how a protein responsible for cell survival in low oxygen can trigger the spread of cancer cells into the lymphatic system in a mouse model of breast cancer. Johns Hopkins is home to the Sidney Kimmel Comprehensive Cancer Center.

  19. UCBerkeleyNews: Cables Hold Promise in Protecting Existing Buildings from Bombs, Researchers Find

    NSDL National Science Digital Library

    Yang, Sarah.

    2003-01-01

    A civil engineering professor at the University of California at Berkeley is working on a novel way of maintaining a building's structural stability after an earthquake or terrorist bomb. The team of researchers working with the professor have designed and tested a system that uses cables for backup support in case main support beams failed. An overview of the system is provided in a February 20, 2003 news article.

  20. Regenerating the Academic Workforce: The Careers, Intentions and Motivations of Higher Degree Research Students in Australia. Findings of the National Research Student Survey (NRSS)

    ERIC Educational Resources Information Center

    Edwards, Daniel; Bexley, Emmaline; Richardson, Sarah

    2010-01-01

    This report is the culmination of a project carried out for the Australian Government Department of Education, Employment and Workplace Relations (DEEWR) by the Australian Council for Educational Research (ACER) in collaboration with the Centre for the Study of Higher Education (CSHE). The main findings of this report are based on the outcomes…

  1. Finding solutions to challenges faced in community-based participatory research between academic and community organizations.

    PubMed

    Shoultz, Jan; Oneha, Mary Frances; Magnussen, Lois; Hla, Mya Moe; Brees-Saunders, Zavi; Cruz, Marissa Dela; Douglas, Margaret

    2006-03-01

    Partnerships between communities and academic institutions have been vital in addressing complex health and psychosocial issues faced by culturally diverse and hard-to-reach populations. Community-based participatory research (CBPR) has been suggested as a strategy to develop trust and build on the strengths of partners from various settings to address significant health issues, particularly those persistent health issues that reveal disparities among minority populations. There have been many challenges to developing these partnerships in the United States. The purpose of this paper is to discuss approaches and solutions used by this research team in response to the challenges they have faced in using CBPR. The team uses CBPR to understand and support the process of disclosure of intimate partner violence (IPV) within the context of the community health centers that provide services for multicultural and multi-lingual populations. While CBPR provides a route to develop trust and build on the strengths of partners from various settings, there are multiple challenges that arise when partnering organizations present with different infrastructures, missions, resources and populations served. Examples of common challenges and solutions from the literature and from the team's experience will be discussed. Implications for partners, partnerships, practice and research will be explored. PMID:16608716

  2. Are LGBT Populations at a Higher Risk for Suicidal Behaviors in Australia? Research Findings and Implications.

    PubMed

    Skerrett, Delaney M; Kõlves, Kairi; De Leo, Diego

    2015-07-01

    The aim of this article is to review the Australian literature about suicidality in minority sexual identity and/or behavior groups in order to determine the evidence base for their reported higher vulnerability to suicidal behaviors than heterosexual and non-transgendered individuals in the Australian context, as well as to identify the factors that are predictive of suicidal behaviors in these groups in Australia. A literature search for all available years (until the end of 2012) was conducted using the databases Scopus, Medline, and Proquest for articles published in English in peer-reviewed academic journals. All peer-reviewed publications that provided empirical evidence for prevalence and predictive factors of suicidal behaviors among LGBT individuals (or a subset thereof) in Australia were included. Reference lists were also scrutinized to identify "gray" literature for inclusion. The results revealed that there is only limited research from Australia. Nevertheless, although no population-based studies have been published, research indicates that sexual minorities are indeed at a higher risk for suicidal behaviors. In order to further the understanding of suicidal behaviors and potential prevention among LGBT groups in the Australia, further research is needed, particularly on fatal suicidal behaviors. PMID:25569508

  3. New findings and setting the research agenda for soil and water conservation for sustainable land management

    NASA Astrophysics Data System (ADS)

    Keesstra, Saskia; Argaman, Eli; Gomez, Jose Alfonso; Quinton, John

    2014-05-01

    The session on soil and water conservation for sustainable land management provides insights into the current research producing viable measures for sustainable land management and enhancing the lands role as provider of ecosystem services. The insights into degradation processes are essential for designing and implementing feasible measures to mitigate against degradation of the land resource and adapt to the changing environment. Land degradation occurs due to multiple pressures on the land, such as population growth, land-use and land-cover changes, climate change and over exploitation of resources, often resulting in soil erosion due to water and wind, which occurs in many parts of the world. Understanding the processes of soil erosion by wind and water and the social and economic constraints faced by farmers forms an essential component of integrated land development projects. Soil and water conservation measures are only viable and sustainable if local environmental and socio-economic conditions are taken into account and proper enabling conditions and policies can be achieved. Land degradation increasingly occurs because land use, and farming systems are subject to rapid environmental and socio-economic changes without implementation of appropriate soil and water conservation technologies. Land use and its management are thus inextricably bound up with development; farmers must adapt in order to sustain the quality of their, and their families, lives. In broader perspective, soil and water conservation is needed as regulating ecosystem service and as a tool to enhance food security and biodiversity. Since land degradation occurs in many parts of the world and threatens food production and environmental stability it affects those countries with poorer soils and resilience in the agriculture sector first. Often these are the least developed countries. Therefore the work from researchers from developing countries together with knowledge from other disciplines and places is essential if we are to develop viable measures and approaches to soil and water conservation across the globe. In this paper we will provide an overview of the topics that are addressed in this session and give an overview of the current research in this field and using the insights we will aim to present a new research agenda oriented towards a significant impact in economic and environmental sustainability.

  4. A decade of research using the CASP scale: key findings and future directions.

    PubMed

    Hyde, M; Higgs, P; Wiggins, R D; Blane, D

    2015-07-01

    Since the publication of A Measure of Quality of Life in Early Old Age: The Theory, Development and Properties of a Needs Satisfaction Model (CASP-19) just over 10 years ago, the scale has gone on to be used in a wide variety of studies in over 20 countries across the world and the original paper has become the most highly cited paper for Aging and Mental Health. Therefore it was felt that it was a good time to look back and reflect on the developments in the use of the scale as well as to look forward to what new research is being done and could be done with the measure. To this end we are extremely grateful for the editors for allowing us to bring together a collection of papers that represent cutting edge research using the CASP scale. These papers cover a wide variety of issues, from working conditions to religiosity, from a range of countries, covering Western and Eastern Europe as well as Africa. Each makes an important individual contribution to our understanding of the factors that influence quality of life in later life as well as pointing to the limitations of the measure and future work that can be done in this area. PMID:25847497

  5. PLUME-FEATHER, Referencing and Finding Software for Research and Education

    NASA Astrophysics Data System (ADS)

    Bénassy, O.; Caron, C.; Ferret-Canape, C.; Cheylus, A.; Courcelle, E.; Dantec, C.; Dayre, P.; Dostes, T.; Durand, A.; Facq, A.; Gambini, G.; Geahchan, E.; Helft, C.; Hoffmann, D.; Ingarao, M.; Joly, P.; Kieffer, J.; Larré, J.-M.; Libes, M.; Morris, F.; Parmentier, H.; Pérochon, L.; Porte, O.; Romier, G.; Rousse, D.; Tournoy, R.; Valeins, H.

    2014-06-01

    PLUME-FEATHER is a non-profit project created to Promote economicaL, Useful and Maintained softwarEFor theHigher Education And THE Research communities. The site references software, mainly Free/Libre Open Source Software (FLOSS) from French universities and national research organisations, (CNRS, INRA...), laboratories or departments as well as other FLOSS software used and evaluated by users within these institutions. Each software is represented by a reference card, which describes origin, aim, installation, cost (if applicable) and user experience from the point of view of an academic user for academic users. Presently over 1000 programs are referenced on PLUME by more than 900 contributors. Although the server is maintained by a French institution, it is open to international contributions in the academic domain. All contained and validated contents are visible to anonymous public, whereas (presently more than 2000) registered users can contribute, starting with comments on single software reference cards up to help with the organisation and presentation of the referenced software products. The project has been presented to the HEP community in 2012 for the first time [1]. This is an update of the status and a call for (further) contributions.

  6. The ethics of sharing preliminary research findings during public health emergencies: a case study from the 2009 influenza pandemic.

    PubMed

    Crowcroft, N S; Rosella, L C; Pakes, B N

    2014-01-01

    During the 2009 A(H1N1) influenza pandemic, a suite of studies conducted in Canada showed an unexpected finding, that patients with medically attended laboratory-confirmed pandemic influenza were more likely to have received seasonal influenza vaccination than test-negative control patients. Different bodies, including scientific journals and government scientific advisory committees, reviewed the evidence simultaneously to determine its scientific validity and implications. Decision-making was complicated when the findings made their way into the media. The normal trajectory of non-urgent research includes peer-review publication after which decision-makers can process the information taking into account other evidence and logistic considerations. In the situation that arose, however, the congruence of an unexpected finding and the simultaneous review of the evidence both within and outside the traditional peer-review sphere raised several interesting issues about how to deal with emerging evidence during a public health emergency. These events are used in this article to aid discussion of the complex interrelationship between researchers, public health decision-makers and scientific journals, the trade-offs between sharing information early and maintaining the peer-review quality assurance process, and to emphasise the need for critical reflection on the practical and ethical norms that govern the way in which research is evaluated, published and communicated in public health emergencies. PMID:24970372

  7. The 35% carbon dioxide test in stress and panic research: overview of effects and integration of findings.

    PubMed

    Vickers, Kristin; Jafarpour, Sepehr; Mofidi, Amirsalar; Rafat, Bijan; Woznica, Andrea

    2012-04-01

    The carbon dioxide test--a vital capacity breath of air containing 35% carbon dioxide (CO(2))--provokes panic attacks in many individuals with panic disorder (PD). It has thus been extensively used as an experimental model of panic and less frequently as a clinical method of provoking symptoms for interoceptive exposure treatment. Recently, stress researchers have suggested another use for the CO(2) test: that of an acute physiological stressor indexing the human stress response. The purpose of this review is to synthesize findings about the effects of the CO(2) test from both the panic and stress literatures in order to advance understanding about this increasingly popular test. Both panic and stress researchers have examined the fleeting effects of the CO(2) test, finding that the test engenders transient breathlessness, dizziness, and minor anxiety in most participants and panic attacks in those with or at risk for PD. Physiological measurements after the test indicate a brief homeostatic disruption in many bodily systems, including increased respiration, systolic blood pressure, and noradrenaline, and decreased heart rate. Most studies indicate increased cortisol. Possible benefits of integrating findings from the panic and stress research lines, given their common use of the CO(2) test, are discussed. PMID:22322014

  8. The impact of migration on gender roles: findings of field research in Turkey.

    PubMed

    Kadioglu, A

    1994-01-01

    "This article suggests an alternative approach to unravel the impact of migration experiences on gender roles of women [in Turkey].... Analysis of the pre-migration settings of women included in this study involves an attempt to delineate background characteristics, including types of marriage and family arrangements, levels of education and work experiences outside the household in order to assess relative impact on their post-migration characteristics.... Differences among the women in terms of their exposure to migration have also been taken into account as part of their migration experiences.... The main focus of the research is changing gender roles of women rather than their emancipation." (SUMMARY IN FRE AND SPA) PMID:12346405

  9. Disaster media coverage and psychological outcomes: descriptive findings in the extant research.

    PubMed

    Pfefferbaum, Betty; Newman, Elana; Nelson, Summer D; Nitiéma, Pascal; Pfefferbaum, Rose L; Rahman, Ambreen

    2014-09-01

    This review of the literature on disaster media coverage describes the events, samples, and forms of media coverage (television, newspapers, radio, internet) studied and examines the association between media consumption and psychological outcomes. A total of 36 studies representing both man-made and natural events met criteria for review in this analysis. Most studies examined disaster television viewing in the context of terrorism and explored a range of outcomes including posttraumatic stress disorder (PTSD) caseness and posttraumatic stress (PTS), depression, anxiety, stress reactions, and substance use. There is good evidence establishing a relationship between disaster television viewing and various psychological outcomes, especially PTSD caseness and PTS, but studies are too few to draw definitive conclusions about the other forms of media coverage that have been examined. As media technology continues to advance, future research is needed to investigate these additional media forms especially newer forms such as social media. PMID:25064691

  10. Measuring Masculinity in Research on Men of Color: Findings and Future Directions

    PubMed Central

    Gunter, Katie; Watkins, Daphne C.

    2012-01-01

    The purpose of this study was to examine the association between masculinity and the health of US men of color aged 18 years and older. We identified 22 population-based studies that included a measure of masculinity and a measure of health behavior, mental health, or physical health. The associations between masculinity and health were complex and varied by construct and health outcome, though they generally were significant in the hypothesized directions. Future research should explore the centrality of masculinity versus other identities and characteristics, how the relationship between masculinity and health varies by health outcome, and the identification of the conceptions and aspects of masculinity that are most relevant to and associated with specific health behaviors and health outcomes. PMID:22401519

  11. Dourine in Southern Africa 1981-1984: serological findings from the Veterinary Research Institute, Onderstepoort.

    PubMed

    Williamson, C C; Herr, S

    1986-09-01

    The distribution of positive dourine cases found on the complement fixation test at the Veterinary Research Institute, Onderstepoort from 1981 to 1984, is recorded. Within the Republic of South Africa, foci of infection occurred in the Johannesburg, Pretoria, Potchefstroom, Rustenburg, Upington, Lichtenburg, Kroonstad, Louis Trichardt, Middelburg (Cape) and Mossel Bay state veterinary districts. In Bophuthatswana, Transkei, Lesotho, South West Africa and Swaziland, positive cases were also recorded. Anti-complementary activity of horse sera does not present a problem. In donkey and mule sera, however, sera show anticomplementary activity in approximately 50% of cases. This can be reduced by diluting the sera 1/2 before inactivating at 63 degrees C for 1 h. PMID:3806561

  12. Inconsistency of scale-invariant curvature coupled to gravity

    NASA Astrophysics Data System (ADS)

    Zoller, D.

    1990-10-01

    We show that the scale-invariant curvature action for paths, the point-particle version of Polyakov's extrinsic-curvature action for surfaces, does not couple consistently to gravity. The curvature action for paths yields a massless representation of the Poincaré group with fixed helicity and so potentially provides a description of single photons and gravitons. We present a physical interpretation of the inconsistency in terms of the nonlocalizability of the photon and point out a conceptual kinship with the local supersymmetry of a spinning particle.

  13. Assessing the Health Needs of Chinese Older Adults: Findings from a Community-Based Participatory Research Study in Chicago's Chinatown

    PubMed Central

    Dong, XinQi; Chang, E-Shien; Wong, Esther; Wong, Bernarda; Skarupski, Kimberly A.; Simon, Melissa A.

    2010-01-01

    The objective of this study is to examine the cultural views of healthy aging, knowledge and barriers to services, and perception of health sciences research among community-dwelling Chinese older adults in Chicago's Chinatown. This qualitative study is guided by the Precede-Proceed conceptual model with community-based participatory research design. Data analysis is based on eight focus group interviews with Chinese older (age 60+) adults (n = 78). We used a grounded theory framework to systematically guide the thematic structure of our data. Findings show participants described cultural conception of health in terms of physical function, psychological well-being, social support, and cognitive function. The availability, affordability, and cultural barriers towards health care services were major negative enabling factors that inhibit participants from fulfilling health needs. Perception and knowledge of health sciences research were also discussed. This study has implications for the delivery of culturally appropriate health care services to the Chinese aging population. PMID:21253522

  14. Identifying trustworthy experts: how do policymakers find and assess public health researchers worth consulting or collaborating with?

    PubMed

    Haynes, Abby S; Derrick, Gemma E; Redman, Sally; Hall, Wayne D; Gillespie, James A; Chapman, Simon; Sturk, Heidi

    2012-01-01

    This paper reports data from semi-structured interviews on how 26 Australian civil servants, ministers and ministerial advisors find and evaluate researchers with whom they wish to consult or collaborate. Policymakers valued researchers who had credibility across the three attributes seen as contributing to trustworthiness: competence (an exemplary academic reputation complemented by pragmatism, understanding of government processes, and effective collaboration and communication skills); integrity (independence, "authenticity", and faithful reporting of research); and benevolence (commitment to the policy reform agenda). The emphases given to these assessment criteria appeared to be shaped in part by policymakers' roles and the type and phase of policy development in which they were engaged. Policymakers are encouraged to reassess their methods for engaging researchers and to maximise information flow and support in these relationships. Researchers who wish to influence policy are advised to develop relationships across the policy community, but also to engage in other complementary strategies for promoting research-informed policy, including the strategic use of mass media. PMID:22403693

  15. Identifying Trustworthy Experts: How Do Policymakers Find and Assess Public Health Researchers Worth Consulting or Collaborating With?

    PubMed Central

    Haynes, Abby S.; Derrick, Gemma E.; Redman, Sally; Hall, Wayne D.; Gillespie, James A.; Chapman, Simon; Sturk, Heidi

    2012-01-01

    This paper reports data from semi-structured interviews on how 26 Australian civil servants, ministers and ministerial advisors find and evaluate researchers with whom they wish to consult or collaborate. Policymakers valued researchers who had credibility across the three attributes seen as contributing to trustworthiness: competence (an exemplary academic reputation complemented by pragmatism, understanding of government processes, and effective collaboration and communication skills); integrity (independence, “authenticity”, and faithful reporting of research); and benevolence (commitment to the policy reform agenda). The emphases given to these assessment criteria appeared to be shaped in part by policymakers' roles and the type and phase of policy development in which they were engaged. Policymakers are encouraged to reassess their methods for engaging researchers and to maximise information flow and support in these relationships. Researchers who wish to influence policy are advised to develop relationships across the policy community, but also to engage in other complementary strategies for promoting research-informed policy, including the strategic use of mass media. PMID:22403693

  16. Enhancing the Participation of African Americans in Health-Related Genetic Research: Findings of a Collaborative Academic and Community-Based Research Study

    PubMed Central

    Millon Underwood, Sandra; Buseh, Aaron G.; Kelber, Sheryl T.; Stevens, Patricia E.; Townsend, Leolia

    2013-01-01

    The involvement of African Americans in research has long been expressed as a concern by the scientific community. While efforts have been undertaken to identify factors inhibiting the participation of African Americans in health-related research, few efforts have been undertaken to have highlight factors associated with their engagement of health-related research. An exploratory study of factors presumed to be associated with participation in health-related research was conducted among a nonprobability sample of African Americans (n = 212) from a large urban community in the Midwest. The study was guided by a framework that hypothesized the influence of knowledge, beliefs, and perceptions about genetics and the involvement of providers in decision-making on willingness to participate in health-related genetic research. The results revealed that knowledge, beliefs, and perceptions about genetics and the involvement of providers were associated with willingness to engage in health-related genetic research (P < .05). The most interesting, however, was that 88.7% of the participants who had not previously been involved in a health-related study who expressed a willingness to participate reported that they “had never been asked.” Study findings suggest the need for research that further examines factors associated with the involvement of African Americans in health-related genetic research. PMID:24369499

  17. On norms and bodies: findings from field research on cosmetic surgery in Rio de Janeiro, Brazil.

    PubMed

    Dorneles de Andrade, Daniela

    2010-05-01

    Brazil has the second highest rate of cosmetic surgery worldwide, provided in a large number of public and private clinics and hospitals, especially in the southeast. This qualitative field research in Rio de Janeiro included participant observation and in-depth interviews with 18 women cosmetic surgery patients, 10 key informants (e.g. psychologists and sociologists) and 12 plastic surgeons. Fifteen of the women were either pre- or post-operative; three had not decided whether to have surgery. When asked about their motivations and expectations of the surgery, the majority of the women said they wanted to be "normal". Most of the surgeons said they acted as empathic companions from decision-making through surgery and beyond. Many of the key informants were critical of what was happening to medical ethics in relation to cosmetic surgery. With the growth in a consumer culture, they saw ethics in medicine becoming more bendable and subject to the "law" of the market. The cult of the body has become a mass phenomenon and taken on an important social dimension in a society where norms and images are broadcast widely by the media. The trend towards body-modification by cosmetic surgery at an early age is increasing dramatically. What demands critical thinking and further investigation are the consequences of cosmetic surgery for physical and mental health. PMID:20541086

  18. Why public information works: Research findings on organizational and individual impact

    SciTech Connect

    Bisconti, A.S.

    1989-01-01

    Broad and growing public recognition of the importance of nuclear energy in the United States is evident in the public opinion polls, continued defeat of antinuclear referenda, positive Congressional actions, and open support by politicians-from the National Conference of State Legislatures to President Bush. At leadership levels, the need to address the looming electricity crisis without increasing dependence on foreign oil or greenhouse gas emissions is being voiced increasingly. Within this context, the industry is beginning to be successful in getting its message across to the American public through national advertising and media and public relations programs of the U.S. Council for Energy Awareness (USCEA). And the author knows that the American Nuclear Society (ANS) Public Information Committee is working hard in complementary kinds of public education. Research shows that the public's attitudes toward nuclear energy become more favorable when they are exposed to public information and that a more active scientific community could greatly increase public recognition of the benefits that nuclear energy provides.

  19. "The role of oxytocin in psychiatric disorders: A review of biological and therapeutic research findings"

    PubMed Central

    Cochran, David; Fallon, Daniel; Hill, Michael; Frazier, Jean A.

    2014-01-01

    Oxytocin is a peptide hormone integral in parturition, milk let-down, and maternal behaviors that has been demonstrated in animal studies to be important in the formation of pair bonds and in social behaviors. This hormone is increasingly recognized as an important regulator of human social behaviors, including social decision making, evaluating and responding to social stimuli, mediating social interactions, and forming social memories. In addition, oxytocin is intricately involved in a broad array of neuropsychiatric functions, and may be a common factor important in multiple psychiatric disorders such as autism, schizophrenia, mood and anxiety disorders. This review article examines the extant literature on the evidence for oxytocin dysfunction in a variety of psychiatric disorders and highlights the need for further research to understand the complex role of the oxytocin system in psychiatric disease to pave the way for developing new therapeutic modalities. Articles were selected that involved human participants with various psychiatric disorders, either comparing oxytocin biology to healthy controls or examining the effects of exogenous oxytocin administration. PMID:24651556

  20. Informationist programme in support of biomedical research: a programme description and preliminary findings of an evaluation

    PubMed Central

    Whitmore, Susan C.; Grefsheim, Suzanne F.; Rankin, Jocelyn A.

    2008-01-01

    Background The informationist programme at the Library of the National Institutes of Health (NIH) in Bethesda, MD, USA has grown to 14 informationists working with 40 clinical and basic science research teams. Purpose This case report, intended to contribute to the literature on informationist programmes, describes the NIH informationist programme including implementation experiences, the informationists' training programme, their job responsibilities and programme outcomes. Brief description The NIH informationist programme was designed to enhance the library's service capacity. Over time, the steps for introducing the service to new groups were formalized to ensure support by leadership, the team being served and the library. Job responsibilities also evolved from traditional library roles to a wide range of knowledge management activities. The commitment by the informationist, the team and the library to continuous learning is critical to the programme's success. Results/outcomes NIH scientists reported that informationists saved them time and contributed to teamwork with expert searching and point-of-need instruction. Process evaluation helped refine the programme. Evaluation method High-level, preliminary outcomes were identified from a survey of scientists receiving informationist services, along with key informant interviews. Process evaluation examined service implementation, informationists' training, and service components. Anecdotal evidence has also indicated a favorable response to the programme. PMID:18494648

  1. Understanding the findings of resilience-related research for fostering the development of African American adolescents.

    PubMed

    Barrow, Frederica H; Armstrong, Mary I; Vargo, Amy; Boothroyd, Roger A

    2007-04-01

    African American youth face a number of challenges to prosocial development that the majority of American youth never encounter. Despite this, the research clearly documents that African American youth often are resilient in the face of these challenges. This article explores various factors associated with resilience in African American children and their implications for practitioners. An ecologic framework described by Bronfenbrenner is used as an organizing framework for understanding interventions at the micro-, mezzo-, and exo-system levels. In this article, the importance of identity formation, maintenance of social networks, and exposure to safe and supportive environments is expressed in conjunction with recommendations for practitioners. Practitioners are encouraged to stress the promotion of ethnic and racial identity and self-efficacy with the youth and their family and the involvement of the youth and family in meaningful activities through local community centers, schools, churches, and other organizations serving youth. A case study of an African American girl, from age 16 into adulthood and motherhood, is presented to illustrate the interplay between protective and risk factors. PMID:17349515

  2. Do Students Eventually Get to Publish their Research Findings? The Case of Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Research in Cameroon

    PubMed Central

    Munung, NS; Vidal, L; Ouwe-Missi-Oukem-Boyer, O

    2014-01-01

    Background: Scientific publication is commonly used to communicate research findings and in most academic/research settings, to evaluate the potential of a researcher and for recruitment and promotion. It has also been said that researchers have the duty to make public, the findings of their research. As a result, researchers are encouraged to share their research findings with the scientific world through peer review publications. In this study, we looked at the characteristics and publication rate of theses that documented studies on human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome in Cameroon. Materials and Methods: To check if a thesis resulted in a publication, we searched: A database of publications on HIV in Cameroon, African Journals Online, PubMed and Google scholar. For each publication we recorded if the student was an author, the position of the student in the author listing, the journal and where the journal was indexed. We also looked at the impact factor of the journals. Results: One hundred and thirty theses/dissertations were included in the study, 74.6% (97/130) were written as part of a medical degree (MD), 23.8% (31/130) a postgraduate (PG) degree and 1.5% (2/130) for a Doctorate/PhD. On a whole, 13.9% (18/130) of the theses resulted in at least one publication in a scientific journal with a total of 22 journal articles, giving a mean publication rate of 0.17 article/thesis, 86.4% (11/22) were indexed on PubMed, 9.1% (2/22) on African Journals Online and 4.6% (1/22) on Google scholar. One PG thesis led to two book chapters. The student was the first author in 22.7% (5/22) of the articles and not an author in 9.1% (2/22) of the articles. Student supervisor was an author in all the articles. Conclusion: This study reveals that most students in Cameroon failed to transform their theses/dissertations to scientific publications. This indicates an urgent need to sensitize students on the importance of presenting their research findings in scientific meetings and peer reviewed journals. There is also a great necessity to build capacity in scientific writing among university students in Cameroon. PMID:24971222

  3. The effect of using inconsistent ocean tidal loading models on GPS coordinate solutions

    NASA Astrophysics Data System (ADS)

    Fu, Yuning; Freymueller, Jeffrey T.; van Dam, Tonie

    2012-06-01

    We use up to a 6-year span of GPS data from 85 globally distributed stations to compare solutions using ocean tidal loading (OTL) corrections computed in different reference frames: center of mass of the solid Earth (CE), and center of mass of the Earth system (CM). We compare solution sets that differ only in the frame used for the OTL model computations, for three types of GPS solutions. In global solutions with all parameters including orbits estimated simultaneously, we find coordinate differences of ~0.3 mm between solutions using OTL computed in CM and OTL computed in CE. When orbits or orbits and clocks are fixed, larger biases appear if the user applies an OTL model inconsistent with that used to derive the orbit and clock products. Network solutions (orbits fixed, satellite clocks estimated) show differences smaller than 0.5 mm due to model inconsistency, but PPP solutions show distortions at the ~1.3 mm level. The much larger effect on PPP solutions indicates that satellite clock estimates are sensitive to the OTL model applied. The time series of coordinate differences shows a strong spectral peak at a period of ~14 days when inconsistent OTL models are applied and smaller peaks at ~annual and ~semi-annual periods, for both ambiguity-free and ambiguity-fixed solutions. These spurious coordinate variations disappear in solutions using consistent OTL models. Users of orbit and clock products must ensure that they use OTL coefficients computed in the same reference frame as the OTL coefficients used by the analysis centers that produced the products they use; otherwise, systematic errors will be introduced into position solutions. All modern products should use loading models computed in the CM frame, but legacy products may require loading models computed in the CE frame. Analysts and authors need to document the frame used for all loading computations in product descriptions and papers.

  4. Increasing Capacity for Stewardship of Oceans and Coasts: Findings of the National Research Council Report

    NASA Astrophysics Data System (ADS)

    Roberts, S. J.; Feeley, M. H.

    2008-05-01

    With the increasing stress on ocean and coastal resources, ocean resource management will require greater capacity in terms of people, institutions, technology and tools. Successful capacity-building efforts address the needs of a specific locale or region and include plans to maintain and expand capacity after the project ends. In 2008, the US National Research Council published a report that assesses past and current capacity-building efforts to identify barriers to effective management of coastal and marine resources. The report recommends ways that governments and organizations can strengthen marine conservation and management capacity. Capacity building programs instill the tools, knowledge, skills, and attitudes that address: ecosystem function and change; processes of governance that influence societal and ecosystem change; and assembling and managing interdisciplinary teams. Programs require efforts beyond traditional sector-by-sector planning because marine ecosystems range from the open ocean to coastal waters and land use practices. Collaboration among sectors, scaling from local community-based management to international ocean policies, and ranging from inland to offshore areas, will be required to establish coordinated and efficient governance of ocean and coastal ecosystems. Barriers Most capacity building activities have been initiated to address particular issues such as overfishing or coral reef degradation, or they target a particular region or country facing threats to their marine resources. This fragmentation inhibits the sharing of information and experience and makes it more difficult to design and implement management approaches at appropriate scales. Additional barriers that have limited the effectiveness of capacity building programs include: lack of an adequate needs assessment prior to program design and implementation; exclusion of targeted populations in decision- making efforts; mismanagement, corruption, or both; incomplete or inappropriate evaluation procedures; and, lack of a coordinated and strategic approach among donors. A New Framework Improving ocean stewardship and ending the fragmentation of current capacity building programs will require a new, broadly adopted framework for capacity building that emphasizes cooperation, sustainability, and knowledge transfer within and among communities. The report identifies four specific features of capacity building that would increase the effectiveness and efficiency of future programs: 1. Regional action plans based on periodic program assessments to guide investments in capacity and set realistic milestones and performance measures. 2. Long-term support to establish self-sustaining programs. Sustained capacity building programs require a diversity of sources and coordinated investments from local, regional, and international donors. 3. Development of leadership and political will. One of the most commonly cited reasons for failure and lack of progress in ocean and coastal governance initiatives is lack of political will. One strategy for strengthening support is to identify, develop, mentor, and reward leaders. 4. Establishment of networks and mechanisms for regional collaboration. Networks bring together those working in the same or similar ecosystems with comparable management or governance challenges to share information, pool resources, and learn from one another. The report also recommends the establishment of regional centers to encourage and support collaboration among neighboring countries.

  5. Are prejudices against disabled persons determined by personality characteristics? Reviewing a theoretical approach on the basis of empirical research findings.

    PubMed

    Cloerkes, G

    1981-01-01

    Taking as point of departure the results obtained from research on prejudice, many authors believe that the quality of attitudes toward disabled persons is influenced by the personality structure of the nondisabled. In order to verify this assumption, a secondary analysis of 67 empirical studies was undertaken. These studies referred to different personality variables such as authoritarianism, ethnocentrism, dogmatism, rigidity, intolerance of ambiguity, cognitive simplicity, anxiety, ego-weakness, self-concept, body-concept, aggressiveness, empathy, intelligence, etc. The results can be summarized as follows: Statistical criteria show that single personality traits have relatively little influence on the attitudes towards disabled persons. An adequate evaluation of the research findings is complicated by, at times, considerable methodological problems which arise when applying the proper test instruments to non-clinical populations. Marked correlations are to be found in particular in the case of authoritarianism, ethnocentrism, intolerance of ambiguity, anxiety, and ego-weakness. The intercorrelations, however, between most of the personality variables are rather high, which by cumulation of "extreme" factors may, in fact, sometimes result in particularly unfavorable attitudes toward the disabled. Thus, personality-related research findings to provide certain valuable explanations. Special attention should be devoted to the multiple connections between personality structure and social structure. PMID:6452419

  6. St Jude researchers find that cancer diagnosis doesn’t increase a child’s risk of post-traumatic stress disorder

    Cancer.gov

    St. Jude Children’s Research Hospital study suggests previous research overestimated PTSD in young cancer patients; new findings highlight the ability of children to adjust and even thrive in response to challenges.

  7. Male abuse of a married or cohabiting female partner: the application of sociological theory to research findings.

    PubMed

    Ellis, D

    1989-01-01

    Does women abuse vary with marital status and, if so, why? The primary objectives of this article are to answer these two questions. A review of research findings indicates that men are more likely to beat women they live with than those they have married. The theoretical accounts of Goode and Gelles are used as a starting point for an explanation of this finding. Implicated in this explanation are social factors operating at the level of society (group memberships), a disjunction between patriarchal societal norms and their existential basis in households (employment patterns), relational norms (ambiguity and flexibility), and social and economic costs. These variables influence woman abuse differentials by either increasing the amount of strain/stress or decreasing the likelihood of effective social regulation. PMID:2487137

  8. Managing misaligned paternity findings in research including sickle cell disease screening in Kenya: ‘Consulting communities’ to inform policy?

    PubMed Central

    Marsh, Vicki; Kombe, Francis; Fitzpatrick, Ray; Molyneux, Sassy; Parker, Michael

    2013-01-01

    The management of misaligned paternity findings raises important controversy worldwide. It has mainly, however, been discussed in the context of high-income countries. Genetic and genomics research, with the potential to show misaligned paternity, are becoming increasingly common in Africa. During a genomics study in Kenya, a dilemma arose over testing and sharing information on paternal sickle cell disease status. This dilemma may be paradigmatic of challenges in sharing misaligned paternity findings in many research and health care settings. Using a deliberative approach to community consultation to inform research practice, we explored residents' views on paternal testing and sharing misaligned paternity information. Between December 2009 and November 2010, 63 residents in Kilifi County were engaged in informed deliberative small group discussions, structured to support normative reflection within the groups, with purposive selection to explore diversity. Analysis was based on a modified framework analysis approach, drawing on relevant social science and bioethics literature. The methods generated in-depth individual and group reflection on morally important issues and uncovered wide diversity in views and values. Fundamental and conflicting values emerged around the importance of family interests and openness, underpinned by disagreement on the moral implications of marital infidelity and withholding truth. Wider consideration of ethical issues emerging in these debates supports locally-held reasoning that paternal sickle cell testing should not be undertaken in this context, in contrast to views that testing should be done with or without the disclosure of misaligned paternity information. The findings highlight the importance of facilitating wider testing of family members of affected children, contingent on the development and implementation of national policies for the management of this inherited disorder. Their richness also illustrates the potential for the approach adopted in this study to strengthen community consultation. PMID:24034967

  9. Peer assessment of aviation performance: inconsistent for good reasons.

    PubMed

    Roth, Wolff-Michael; Mavin, Timothy J

    2015-03-01

    Research into expertise is relatively common in cognitive science concerning expertise existing across many domains. However, much less research has examined how experts within the same domain assess the performance of their peer experts. We report the results of a modified think-aloud study conducted with 18 pilots (6 first officers, 6 captains, and 6 flight examiners). Pairs of same-ranked pilots were asked to rate the performance of a captain flying in a critical pre-recorded simulator scenario. Findings reveal (a) considerable variance within performance categories, (b) differences in the process used as evidence in support of a performance rating, (c) different numbers and types of facts (cues) identified, and (d) differences in how specific performance events affect choice of performance category and gravity of performance assessment. Such variance is consistent with low inter-rater reliability. Because raters exhibited good, albeit imprecise, reasons and facts, a fuzzy mathematical model of performance rating was developed. The model provides good agreement with observed variations. PMID:25052893

  10. RESEARCH FINDINGS BASIC NEUROSCIENCES RESEARCH

    E-print Network

    Bandettini, Peter A.

    Receptor Subunits in the Ventral Tegmental Area Enhances Motivation for Cocaine Chronic cocaine use produces numerous biological changes in brain, but relatively few are functionally associated with cocaine reinforcement. Here the authors show that daily intravenous cocaine self-administration, but not passive cocaine

  11. The inconsistent mediating effects of psychosocial work characteristics on the education-health relationship.

    PubMed

    Qiu, Hanyao; Bures, Regina; Shehan, Constance L

    2012-10-01

    This study examined the relationship between psychosocial work characteristics and educational disparities in health. Informed by the evidence on the relationship between work pressure and higher education, we suggested reframing the distribution of psychosocial work characteristics in the context of education. We differentiated psychosocial work resources from demands and hypothesized that the inconsistent mediation effects of psychosocial resources and demands are associated with educational status. Using data from the 2008 National Study of Changing Workforce (NSCW), we found that psychosocial work resources and demands had inconsistent mediating effects on the education-health relationship. Higher educated employees were more likely to report autonomy, challenge and schedule control, but they were also more likely to experience overtime hours, job overload and work-family conflict. Work resources appeared to protect higher-educated workers from stress and health problems while work demands put them at risk of less favorable health outcomes. In addition we found that the 'costs' of psychosocial work demands were stronger among women, particularly those who were highly educated, suggesting that highly educated women did not reap the full health benefit of high educational attainment. Our findings illustrate that the observed positive associations between education and health mask important heterogeneity in the effects of psychosocial work characteristics. We discuss the implications of this study for health and family-based work policies. PMID:22800919

  12. All that glitters is not BOLD: inconsistencies in functional MRI

    NASA Astrophysics Data System (ADS)

    Renvall, Ville; Nangini, Cathy; Hari, Riitta

    2014-01-01

    The blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal is a widely-accepted marker of brain activity. The acquisition parameters (APs) of fMRI aim at maximizing the signals related to neuronal activity while minimizing unrelated signal fluctuations. Currently, a diverse set of APs is used to acquire BOLD fMRI data. Here we demonstrate that some fMRI responses are alarmingly inconsistent across APs, ranging from positive to negative, or disappearing entirely, under identical stimulus conditions. These discrepancies, resulting from non-BOLD effects masquerading as BOLD signals, have remained largely unnoticed because studies rarely employ more than one set of APs. We identified and characterized non-BOLD responses in several brain areas, including posterior cingulate cortex and precuneus, as well as AP-dependence of both the signal time courses and of seed-based functional networks, noticing that AP manipulation can inform about the origin of the measured signals.

  13. Employee Commitment and Well-Being: A Critical Review, Theoretical Framework and Research Agenda

    ERIC Educational Resources Information Center

    Meyer, John P.; Maltin, Elyse R.

    2010-01-01

    Although a great deal is known about the implications of employee commitment for organizations, less attention has been paid to its ramifications for employees themselves. Previous research has been unsystematic and the findings have sometimes been inconsistent. The most consistent findings pertain to the positive links between affective…

  14. Employee commitment and well-being: A critical review, theoretical framework and research agenda

    Microsoft Academic Search

    John P. Meyer; Elyse R. Maltin

    2010-01-01

    Although a great deal is known about the implications of employee commitment for organizations, less attention has been paid to its ramifications for employees themselves. Previous research has been unsystematic and the findings have sometimes been inconsistent. The most consistent findings pertain to the positive links between affective commitment and employee well-being. Relations between continuance commitment and well-being are more

  15. A Review of Humor in Educational Settings: Four Decades of Research

    ERIC Educational Resources Information Center

    Banas, John A.; Dunbar, Norah; Rodriguez, Dariela; Liu, Shr-Jie

    2011-01-01

    The primary goal of this project is to provide a summary of extant research regarding humor in the classroom, with an emphasis on identifying and explaining inconsistencies in research findings and offering new directions for future studies in this area. First, the definitions, functions, and main theories of humor are reviewed. Next, the paper…

  16. Finding Canadian Government Pubs.

    E-print Network

    Haykin, Simon

    Finding Canadian Government Pubs. Econ 773 Peggy Findlay Reference Librarian Mills Research Help 2 Objectives Finding print Canadian government publications Electronic Canadian government publications Census Information/ Survey Data #12;Finding Canadian Documents ­ Econ 773 Finding Print Canadian Government

  17. Estimating nonrigid motion from inconsistent intensity with robust shape features

    SciTech Connect

    Liu, Wenyang [Department of Bioengineering, University of California, Los Angeles, California 90095 (United States)] [Department of Bioengineering, University of California, Los Angeles, California 90095 (United States); Ruan, Dan, E-mail: druan@mednet.ucla.edu [Department of Bioengineering, University of California, Los Angeles, California 90095 (United States) [Department of Bioengineering, University of California, Los Angeles, California 90095 (United States); Department of Radiation Oncology, University of California, Los Angeles, California 90095 (United States); Department of Biomedical Physics, University of California, Los Angeles, California 90095 (United States)

    2013-12-15

    Purpose: To develop a nonrigid motion estimation method that is robust to heterogeneous intensity inconsistencies amongst the image pairs or image sequence. Methods: Intensity and contrast variations, as in dynamic contrast enhanced magnetic resonance imaging, present a considerable challenge to registration methods based on general discrepancy metrics. In this study, the authors propose and validate a novel method that is robust to such variations by utilizing shape features. The geometry of interest (GOI) is represented with a flexible zero level set, segmented via well-behaved regularized optimization. The optimization energy drives the zero level set to high image gradient regions, and regularizes it with area and curvature priors. The resulting shape exhibits high consistency even in the presence of intensity or contrast variations. Subsequently, a multiscale nonrigid registration is performed to seek a regular deformation field that minimizes shape discrepancy in the vicinity of GOIs. Results: To establish the working principle, realistic 2D and 3D images were subject to simulated nonrigid motion and synthetic intensity variations, so as to enable quantitative evaluation of registration performance. The proposed method was benchmarked against three alternative registration approaches, specifically, optical flow, B-spline based mutual information, and multimodality demons. When intensity consistency was satisfied, all methods had comparable registration accuracy for the GOIs. When intensities among registration pairs were inconsistent, however, the proposed method yielded pronounced improvement in registration accuracy, with an approximate fivefold reduction in mean absolute error (MAE = 2.25 mm, SD = 0.98 mm), compared to optical flow (MAE = 9.23 mm, SD = 5.36 mm), B-spline based mutual information (MAE = 9.57 mm, SD = 8.74 mm) and mutimodality demons (MAE = 10.07 mm, SD = 4.03 mm). Applying the proposed method on a real MR image sequence also provided qualitatively appealing results, demonstrating good feasibility and applicability of the proposed method. Conclusions: The authors have developed a novel method to estimate the nonrigid motion of GOIs in the presence of spatial intensity and contrast variations, taking advantage of robust shape features. Quantitative analysis and qualitative evaluation demonstrated good promise of the proposed method. Further clinical assessment and validation is being performed.

  18. Reducing Adverse Childhood Experiences (ACE) by Building Community Capacity: A Summary of Washington Family Policy Council Research Findings

    PubMed Central

    Hall, Judy; Porter, Laura; Longhi, Dario; Becker-Green, Jody; Dreyfus, Susan

    2012-01-01

    Community capacity for organization and collaboration has been shown to be a powerful tool for improving the health and well-being of communities. Since 1994 the Washington State Family Policy Council has supported the development of community capacity in 42 community public health and safety networks. Community networks bring local communities together to restructure natural supports and local resources to meet the needs of families and children, and increase cross-system coordination and flexible funding streams to improve local services and policy. In this study, researchers sought to demonstrate the strong impact of the community networks’ capacity to interrupt health and social problems. Findings suggest that community networks reduce health and safety problems for the entire community population. Further, community networks with high community capacity reduced adverse childhood experiences (ACE) in young adults ages 18–34. PMID:22970785

  19. Health effects of tropospheric ozone: Review of recent research findings and their implications to ambient air quality standards

    SciTech Connect

    Lippmann, M. (New York Univ. Medical Center, Tuxedo (United States))

    1993-01-01

    The US Environmental Protection Agency (EPA) Administrator proposed (on August 3, 1992) to retain the current National Ambient Air Quality Standard (NAAQS) for ozone (O3) on the basis of data assembled in a draft Criteria Document (1986) and its Addendum (1988) which, together with a draft Staff Paper (1988), received public comment and review comments by the EPA's Clean Air Scientific Advisory Committee (CASAC). This paper summarizes and discusses research findings presented since 1988 which, based on the author's experience as a Chairman of CASAC, are most relevant to the promulgation of a primary (health based) NAAQS for O3. These newer findings include substantial evidence from controlled chamber exposure studies and field studies in natural settings that the current NAAQS contains no margin of safety against short-term effects that the EPA has considered to be adverse. They also include evidence from epidemiologic studies that current ambient exposures are associated with reduced baseline lung function, exacerbation of asthma and premature mortality, as well as evidence from chronic animal exposure studies at concentrations within current ambient peak levels that indicate progressive and persistent lung function and structural abnormalities. The current NAAQS, if retained, may therefore also be inadequate to protect the public from effects resulting from chronic exposure to O3. 96 refs.

  20. Health effects of tropospheric ozone: review of recent research findings and their implications to ambient air quality standards.

    PubMed

    Lippmann, M

    1993-01-01

    The U.S. Environmental Protection Agency (EPA) Administrator proposed (on August 3, 1992) to retain the current National Ambient Air Quality Standard (NAAQS) for ozone (O3) on the basis of data assembled in a draft Criteria Document (1986) and its Addendum (1988) which, together with a draft Staff Paper (1988), received public comment and review comments by the EPA's Clean Air Scientific Advisory Committee (CASAC). This paper summarizes and discusses research findings presented since 1988 which, based on the author's experience as a Chairman of CASAC, are most relevant to the promulgation of a primary (health based) NAAQS for O3. These newer findings include substantial evidence from controlled chamber exposure studies and field studies in natural settings that the current NAAQS contains no margin of safety against short-term effects that the EPA has considered to be adverse. They also include evidence from epidemiologic studies that current ambient exposures are associated with reduced baseline lung function, exacerbation of asthma and premature mortality, as well as evidence from chronic animal exposure studies at concentrations within current ambient peak levels that indicate progressive and persistent lung function and structural abnormalities. The current NAAQS, if retained, may therefore also be inadequate to protect the public from effects resulting from chronic exposure to O3. PMID:8518544

  1. On the adjustment of inconsistent data using the Birge ratio

    NASA Astrophysics Data System (ADS)

    Bodnar, Olha; Elster, Clemens

    2014-10-01

    The Birge ratio is applied in metrology to enlarge quoted uncertainties when combining inconsistent measurement results on the same measurand. We discuss the statistical model underlying such a procedure and argue that the resulting uncertainty associated with the adjusted value is underrated. We provide a simple modification of this uncertainty on the basis of an objective Bayesian inference. While the proposed uncertainty approaches that obtained by the conventional procedure for a large number n of combined measurement results, differences are significant for small n. For example, for n = 4 we get an increase of 73% in the standard uncertainty associated with the adjusted value, and for n = 10 the increase is still 13%. We derive the posterior distribution for the adjusted value in closed form, including a 95% credible interval. In addition, we show that our results do not only hold when the distribution of the measurement results is assumed to be Gaussian, but for a whole family of (elliptically contoured) location-scale distributions. We illustrate the modified Birge method by its application to data from the 2002 adjustment of the Newtonian constant of gravitation.

  2. Earth's Climate Sensitivity: Apparent Inconsistencies in Recent Assessments

    NASA Astrophysics Data System (ADS)

    Schwartz, Stephen E.; Charlson, Robert J.; Kahn, Ralph; Rodhe, Henning

    2014-12-01

    Earth's equilibrium climate sensitivity (ECS) and forcing of Earth's climate system over the industrial era have been re-examined in two new assessments: the Fifth Assessment Report (AR5) of the Intergovernmental Panel on Climate Change (IPCC), and a study by Otto et al. (2013). The ranges of these quantities given in these assessments and also in the Fourth (2007) IPCC Assessment are analyzed here within the framework of a planetary energy balance model, taking into account the observed increase in global mean surface temperature over the instrumental record together with best estimates of the rate of increase of planetary heat content. This analysis shows systematic differences among the several assessments and apparent inconsistencies within individual assessments. Importantly, the likely range of ECS to doubled CO2 given in AR5, 1.5-4.5 K/(3.7 W m-2) exceeds the range inferred from the assessed likely range of forcing, 1.2-2.9 K/(3.7 W m-2), where 3.7 W m-2 denotes the forcing for doubled CO2. Such differences underscore the need to identify their causes and reduce the underlying uncertainties. Explanations might involve underestimated negative aerosol forcing, overestimated total forcing, overestimated climate sensitivity, poorly constrained ocean heating, limitations of the energy balance model, or a combination of effects.

  3. An eight-year snapshot of geospatial cancer research (2002-2009): clinico-epidemiological and methodological findings and trends.

    PubMed

    Boulos, Dina N Kamel; Ghali, Ramy R; Ibrahim, Ezzeldin M; Boulos, Maged N Kamel; AbdelMalik, Philip

    2011-12-01

    Geographic information systems (GIS) offer a very rich toolbox of methods and technologies, and powerful research tools that extend far beyond the mere production of maps, making it possible to cross-link and study the complex interaction of disease data and factors originating from a wide range of disparate sources. Despite their potential indispensable role in cancer prevention and control programmes, GIS are underrepresented in specialised oncology literature. The latter has provided an impetus for the current review. The review provides an eight-year snapshot of geospatial cancer research in peer-reviewed literature (2002-2009), presenting the clinico-epidemiological and methodological findings and trends in the covered corpus (93 papers). The authors concluded that understanding the relationship between location and cancer/cancer care services can play a crucial role in disease control and prevention, and in better service planning, and appropriate resource utilisation. Nevertheless, there are still barriers that hinder the wide-scale adoption of GIS and related technologies in everyday oncology practice. PMID:20589539

  4. Finding people who will tell you their thoughts on genomics-recruitment strategies for social sciences research.

    PubMed

    Middleton, A; Bragin, E; Parker, M

    2014-10-01

    This paper offers a description of how social media, traditional media and direct invitation were used as tools for the recruitment of 6,944 research participants for a social sciences study on genomics. The remit was to gather the views of various stakeholders towards sharing incidental findings from whole genome studies. This involved recruiting members of the public, genetic health professionals, genomic researchers and non-genetic health professionals. A novel survey was designed that contained ten integrated films; this was made available online and open for completion by anyone worldwide. The recruitment methods are described together with the convenience and snowballing sampling framework. The most successful strategy involved the utilisation of social media; Facebook, Blogging, Twitter, LinkedIn and Google Ads led to the ascertainment of over 75 % of the final sample. We conclude that the strategies used were successful in recruiting in eclectic mix of appropriate participants. Design of the survey and results from the study are presented separately. PMID:24535681

  5. Knowledge, ignorance and priorities for research in key areas of cancer survivorship: findings from a scoping review

    PubMed Central

    Richardson, A; Addington-Hall, J; Amir, Z; Foster, C; Stark, D; Armes, J; Brearley, S G; Hodges, L; Hook, J; Jarrett, N; Stamataki, Z; Scott, I; Walker, J; Ziegler, L; Sharpe, M

    2011-01-01

    Background: Patients who have completed initial cancer treatment (cancer survivors) have been relatively neglected. We need data to help us better understand the needs of this group and to underpin evidence-based service development. Methods: Scoping reviews of research published in the last two decades focussing on the problems faced by cancer survivors, and the effectiveness of interventions for these problems were undertaken. The aim was to identify what we know, what we do not know and opportunities where research could provide new information. We searched for, retrieved and rapidly appraised systematic reviews sourced from the most common electronic databases supplemented by more recently published individual studies. Results: The research evidence is surprisingly limited. We have some knowledge of the prevalence and nature of depression, pain and fatigue in cancer survivors. We know much less about cognitive and physical impairment, employment, financial well-being and relationships. Even where we have evidence, it is mostly of only moderate quality, is most often only for breast cancer and focuses almost exclusively on the early phase of survivorship. We have good evidence for the effectiveness of drug treatments for pain and moderate evidence for fatigue and depression, but not for other symptoms. Interventions based on rehabilitative and self-management approaches remain in the early stages of evaluation. Interpretation: There has been a substantial amount of research describing many of the problems experienced by the cancer survivors. This is strongest in the area of symptoms in the period soon after treatment. However, the quality of the evidence is often poor, and some topics have been little examined. We urgently need data on the natural evolution and scale of the problems of cancer survivors obtained from well-designed, large-scale cohort studies and the robust testing of interventions in clinical trials. Given the current financially constrained research funding environment, we suggest areas in which strategic investment might give findings that have the potential to make a major impact on patient well-being in a 5-year time scale. PMID:22048036

  6. Inconsistencies in emergency instructions on common household product labels.

    PubMed

    Cantrell, F Lee; Nordt, Sean Patrick; Krauss, Jamey R

    2013-10-01

    Human exposures to non-pharmaceutical products often results in serious injury and death annually in the United States. Studies performed more than 25 years ago described inadequate first aid advice on the majority of household products. The current study evaluates contemporary non-pharmaceutical products with respect to location, uniformity and type of their first aid and emergency contact instructions. A random, convenience sample of commercial product label information was obtained from local retail stores over an 8 month period. Twelve common non-pharmaceutical product categories, with large numbers of annual human exposures, were identified from National Poison Data Systems data. A minimum of 10 unique products for each category utilized. The following information identified: product name and manufacturer, location on container, presence and type of route-specific treatment, medical assistance referral information. A total of 259 product labels were examined. First aid/contact information was located on container: rear 162 (63 %), side 28 (11 %), front 3 (1 %), bottom 2 (0.77 %), behind label 14 (5 %), missing entirely 50 (19 %). Fifty-five products (21 %) lacked any first aid instructions. Suggested contacts for accidental poisoning: none listed 75 (29 %), physician 144 (56 %), poison control centers 102 (39 %), manufacturer 44 (17 %), "Call 911" 10 (4 %). Suggested contacts for unintentional exposure and content of first aid instructions on household products were inconsistent, frequently incomplete and at times absent. Instruction locations similarly lacked uniformity. Household product labels need to provide concise, accurate first aid and emergency contact instructions in easy-to-understand language in a universal format on product labels. PMID:23584666

  7. An Analysis of Inconsistencies Between ITS-90 Interpolations Above 0.01 °C

    NASA Astrophysics Data System (ADS)

    Kang, Zhiru; Lan, Jingbo; Zhang, Jintao; Hill, K. D.; Sun, Jianping; Chen, Jin

    2011-01-01

    Inconsistencies in the ITS-90 interpolations above 0.01 °C have been investigated. Thirty-five standard platinum resistance thermometers are used to determine the magnitude of inconsistencies in this range with the exception of the overlap region of the water-zinc and water-aluminum sub-ranges. The results show inconsistencies that are less 4.1 mK. Simpler representations of ten of the fifteen inconsistency functions above 0.01 °C are presented by means of factoring and extremum analysis.

  8. More Research Questions: Rebuttal to Bornstein, Langer, and Stickney

    Microsoft Academic Search

    Lillian M. Range; Sharon Rae Jenkins

    2010-01-01

    Stickney (2010), Bornstein (2010), and Langer (2010) expand the research recommendations for experimental writing research\\u000a that Range and Jenkins (2010) generated from gender schema, gender role, and socialization theory. Stickney derives research\\u000a questions from communication and emotion theory. Bornstein and Langer focus on assessment in this paradigm. Bornstein’s multimodal\\u000a assessment strategy might improve understanding of apparently inconsistent findings, indicate unstudied

  9. CNS tumors and exposure to acrylonitrile: inconsistency between experimental and epidemiology studies.

    PubMed

    Collins, J J; Strother, D E

    1999-07-01

    Acrylonitrile is a potent CNS tumorigen in rats leading to concern that it may be a tumorigen in humans. There have been 12 epidemiology studies of 37,352 workers exposed to acrylonitrile which evaluate CNS cancers. We summarize and evaluate these epidemiology studies for CNS cancers using the methods of meta-analysis. Our analyses indicate that workers with acrylonitrile exposure have null findings for CNS cancer (relative risk = 1.1, 95% confidence interval 0.8-1.5), which are in stark contrast to the projected risk to humans using the rat findings (relative risk = 3.5, 95% confidence interval 3.0-4.0). We discuss several explanations for the inconsistency between animal and human findings, including the possibility that the acrylonitrile-induced rat CNS tumors may not be relevant to humans. Given the rarity of CNS tumors in humans and a lack of understanding of the causal mechanisms of these tumors in rats, however, a more definitive conclusion will have to await additional experimental and observational data. Nevertheless, the epidemiology evidence indicates that acrylonitrile is not a potent CNS tumorigen. PMID:11550315

  10. CNS tumors and exposure to acrylonitrile: inconsistency between experimental and epidemiology studies.

    PubMed Central

    Collins, J. J.; Strother, D. E.

    1999-01-01

    Acrylonitrile is a potent CNS tumorigen in rats leading to concern that it may be a tumorigen in humans. There have been 12 epidemiology studies of 37,352 workers exposed to acrylonitrile which evaluate CNS cancers. We summarize and evaluate these epidemiology studies for CNS cancers using the methods of meta-analysis. Our analyses indicate that workers with acrylonitrile exposure have null findings for CNS cancer (relative risk = 1.1, 95% confidence interval 0.8-1.5), which are in stark contrast to the projected risk to humans using the rat findings (relative risk = 3.5, 95% confidence interval 3.0-4.0). We discuss several explanations for the inconsistency between animal and human findings, including the possibility that the acrylonitrile-induced rat CNS tumors may not be relevant to humans. Given the rarity of CNS tumors in humans and a lack of understanding of the causal mechanisms of these tumors in rats, however, a more definitive conclusion will have to await additional experimental and observational data. Nevertheless, the epidemiology evidence indicates that acrylonitrile is not a potent CNS tumorigen. PMID:11550315

  11. Healthy Universities: current activity and future directions--findings and reflections from a national-level qualitative research study.

    PubMed

    Dooris, Mark; Doherty, Sharon

    2010-09-01

    This qualitative study used questionnaires to scope and explore 'healthy universities' activity taking place within English higher education institutions (HEIs). The findings revealed a wealth of health-related activity and confirmed growing interest in the healthy universities approach--reflecting an increasing recognition that investment for health within the sector will contribute not only to health targets but also to mainstream agendas such as staff and student recruitment, experience and retention; and institutional and societal productivity and sustainability. However, they also suggested that, while there is growing understanding of the need for a comprehensive whole system approach to improving health within higher education settings, there are a number of very real challenges--including a lack of rigorous evaluation, the difficulty of integrating health into a 'non-health' sector and the complexity of securing sustainable cultural change. Noting that health and well-being remain largely marginal to the core mission and organization of higher education, the article goes on to reflect on the wider implications for future research and policy at national and international levels. Within England, whereas there are Healthy Schools and Healthy Further Education Programmes, there is as yet no government-endorsed programme for universities. Similarly, at an international level, there has been no systematic investment in higher education mirroring the comprehensive and multifaceted Health Promoting Schools Programme. Key issues highlighted are: securing funding for evaluative research within and across HEIs to enable the development of a more robust evidence base for the approach; advocating for an English National Healthy Higher Education Programme that can help to build consistency across the entire spectrum of education; and exploring with the World Health Organization (WHO) and the International Union for Health Promotion and Education (IUHPE) the feasibility of developing an international programme. PMID:21495435

  12. Inconsistencies among European Union Pharmaceutical Regulator Safety Communications: A Cross-Country Comparison

    PubMed Central

    Zeitoun, Jean-David; Lefèvre, Jérémie H.; Downing, Nicholas; Bergeron, Henri; Ross, Joseph S.

    2014-01-01

    Background The European Medicines Agency (EMA) and national regulators share the responsibility to communicate to healthcare providers postmarketing safety events but little is known about the consistency of this process. We aimed to compare public availability of safety-related communications and drug withdrawals from the EMA and European Union member countries for novel medicines. Methods and Findings We performed a cross-sectional analysis using public Dear Healthcare Professional Communications (DHPCs) for all novel medicines authorized between 2001 and 2010 by the EMA and available for use in France, Netherlands, Spain, and the United Kingdom. Between 2001 and 2010, the EMA approved 185 novel medicines. DHPCs could not be ascertained for the EMA. Among the 4 national regulators, as of April 30, 2013, at least one safety DHPC or withdrawal occurred for 53 (28.6%) medicines, totaling 90 DHPCs and 5 withdrawals. Among these 53 medicines, all 4 national agencies issued at least one communication for 17 (32.1%), three of the four for 25 (47.2%), two of the four for 6 (11.3%), and one of the four for 5 (9.4%). Five drugs were reported to be withdrawn, three by all four countries, one by three and one by two. Among the 95 DHPCs and withdrawals, 20 (21.1%) were issued by all 4 national regulators, 37 (38.9%) by 3 of the 4, 22 (23.2%) by 2 of the 4, and 16 (16.8%) by one. Consistency of making publicly available all identified safety DHPC or withdrawal across regulator pairs varied from 33% to 73% agreement. Conclusions Safety communications were not made publicly available by the EMA. Among the 4 European member countries with national regulators that make DHPCs publicly available since at least 2001, there were substantial inconsistencies in safety communications for novel medicines. The impact of those inconsistencies in terms of public health remains to be determined. PMID:25333986

  13. Using Abductive Research Logic: "The Logic of Discovery", to Construct a Rigorous Explanation of Amorphous Evaluation Findings

    ERIC Educational Resources Information Center

    Levin-Rozalis, Miri

    2010-01-01

    Background: Two kinds of research logic prevail in scientific research: deductive research logic and inductive research logic. However, both fail in the field of evaluation, especially evaluation conducted in unfamiliar environments. Purpose: In this article I wish to suggest the application of a research logic--"abduction"--"the logic of…

  14. What if Indigenous Knowledge Contradicts Accepted Scientific Findings?--The Hidden Agenda: Respect, Caring and Passion towards Aboriginal Research in the Context of Applying Western Academic Rules

    ERIC Educational Resources Information Center

    Witt, Norbert

    2007-01-01

    The statement in the title, what if Indigenous Knowledge contradicts accepted scientific findings (Fowler, 2000), is an expression of the dilemma people who research Indigenous Knowledge think they find themselves in when they are confronted with different interpretations of what it means to be human, or, as I may summarize it, with different…

  15. Inconsistencies of the Evaluation of Home Advantage in Sports Competitions Under the Three Points Per Victory System

    PubMed Central

    García, Miguel Saavedra; Aguilar, Óscar Gutiérrez; Fernández Romero, Juan J.

    2014-01-01

    A recent letter sent to the Journal of Human Kinetics’ editor (Gómez & Pollard, 2014) warned about a supposed methodology error in the calculation of home advantage in football leagues used in Saavedra et al. (2013) and took the liberty of modifying the research’s data. The aim of this letter is to demonstrate that the evaluation system of the home advantage proposed by Pollard (1986) contains serious inconsistencies when applied to competitions which give three points for a win and one point for a draw, as it is the case of the UEFA football leagues in the 21th century. PMID:25414734

  16. DCCPS: Health Behavior Constructs: Theory, Measurement, & Research

    Cancer.gov

    In an effort to reduce the "literal inconsistency" problem (the inconsistency between what people say and what they do) and therefore increase the observed relation between proximal antecedents and behavior, researchers have explored other types of proximal measures.

  17. The Relationship between Everyday Problem Solving and Inconsistency in Reaction Time in Older Adults

    Microsoft Academic Search

    Catherine L. Burton; Esther Strauss; David F. Hultsch; Michael A. Hunter

    2009-01-01

    The purpose of the present study was to investigate whether inconsistency in reaction time (RT) is predictive of older adults' ability to solve everyday problems. A sample of 304 community dwelling non-demented older adults, ranging in age from 62 to 92, completed a measure of everyday problem solving, the Everyday Problems Test (EPT). Inconsistency in latencies across trials was assessed

  18. Inconsistencies within Attachment Teaching Practice in Zimbabwe: Call for a Participatory Model

    ERIC Educational Resources Information Center

    Chikunda, Charles

    2008-01-01

    This article raises some inconsistencies observed in attachment teaching practice in Zimbabwe. The argument made is that these inconsistencies are caused by the different philosophical approaches informing attachment teaching practice and its delivery, which is largely visible in teaching practice supervision. The discussion shows that while…

  19. Recall of Information Separating Two Inconsistent Propositions: An Experimental Test of the "Cognitive Dumping" Hypothesis.

    ERIC Educational Resources Information Center

    Clark, Henry T., III

    A study investigated free recall of information bounded by internally inconsistent sentences compared to the same information in consistent text versions. Data were elicited from 40 undergraduate students enrolled in classes in educational psychology. Subjects were instructed to read one consistent and one inconsistent (containing two propositions…

  20. Parents' Attitudes about Adolescents' Premarital Sexual Activity: The Role of Inter-Parent Consistency/Inconsistency in Sexual Outcomes

    ERIC Educational Resources Information Center

    Somers, Cheryl L.; Anagurthi, Claudia

    2014-01-01

    Objective: Parents' values about sexuality and about premarital sex play unique roles in the development of adolescents' sexual attitudes and behaviours. However, research is scarce on the role of consistent versus inconsistent values transmission. The purpose of the present study was to examine the association between parental…

  1. An Approach for Detecting Inconsistencies between Behavioral Models of the Software Architecture and the Code

    SciTech Connect

    Ciraci, Selim; Sozer, Hasan; Tekinerdogan, Bedir

    2012-07-16

    In practice, inconsistencies between architectural documentation and the code might arise due to improper implementation of the architecture or the separate, uncontrolled evolution of the code. Several approaches have been proposed to detect the inconsistencies between the architecture and the code but these tend to be limited for capturing inconsistencies that might occur at runtime. We present a runtime verification approach for detecting inconsistencies between the dynamic behavior of the architecture and the actual code. The approach is supported by a set of tools that implement the architecture and the code patterns in Prolog, and support the automatic generation of runtime monitors for detecting inconsistencies. We illustrate the approach and the toolset for a Crisis Management System case study.

  2. Factors influencing the utilization of research findings by health policy-makers in a developing country: the selection of Mali's essential medicines

    PubMed Central

    Albert, Michael A; Fretheim, Atle; Maïga, Diadié

    2007-01-01

    Background Research findings are increasingly being recognized as an important input in the formation of health policy. There is concern that research findings are not being utilized by health policy-makers to the extent that they could be. The factors influencing the utilization of various types of research by health policy-makers are beginning to emerge in the literature, however there is still little known about these factors in developing countries. The object of this study was to explore these factors by examining the policy-making process for a pharmaceutical policy common in developing countries; an essential medicines list. Methods A study of the selection and updating of Mali's national essential medicines list was undertaken using qualitative methods. In-depth semi-structured interviews and a natural group discussion were held with national policy-makers, most specifically members of the national commission that selects and updates the country's list. The resulting text was analyzed using a phenomenological approach. A document analysis was also performed. Results Several factors emerged from the textual data that appear to be influencing the utilization of health research findings for these policy-makers. These factors include: access to information, relevance of the research, use of research perceived as a time consuming process, trust in the research, authority of those who presented their view, competency in research methods, priority of research in the policy process, and accountability. Conclusion Improving the transfer of research to policy will require effort on the part of researchers, policy-makers, and third parties. This will include: collaboration between researchers and policy-makers, increased production and dissemination of relevant and useful research, and continued and improved technical support from networks and multi-national organizations. Policy-makers from developing countries will then be better equipped to make informed decisions concerning their health policy issues. PMID:17338810

  3. Processes and preliminary outputs for identification of actionable genes as incidental findings in genomic sequence data in the Clinical Sequencing Exploratory Research Consortium

    PubMed Central

    Berg, Jonathan S.; Amendola, Laura M.; Eng, Christine; Van Allen, Eliezer; Gray, Stacy W.; Wagle, Nikhil; Rehm, Heidi L.; DeChene, Elizabeth T.; Dulik, Matthew C.; Hisama, Fuki M.; Burke, Wylie; Spinner, Nancy B.; Garraway, Levi; Green, Robert C.; Plon, Sharon; Evans, James P.; Jarvik, Gail P.

    2014-01-01

    As genomic and exomic testing expands in both the research and clinical arenas, determining whether, how, and which incidental findings to return to the ordering clinician and patient becomes increasingly important. Although opinion is varied on what should be returned to consenting patients or research participants, most experts agree that return of medically actionable results should be considered. There is insufficient evidence to fully inform evidence-based clinical practice guidelines regarding return of results from genome-scale sequencing, and thus generation of such evidence is imperative, given the rapidity with which genome-scale diagnostic tests are being incorporated into clinical care. We present an overview of the approaches to incidental findings by members of the Clinical Sequencing Exploratory Research network, funded by the National Human Genome Research Institute, to generate discussion of these approaches by the clinical genomics community. We also report specific lists of “medically actionable” genes that have been generated by a subset of investigators in order to explore what types of findings have been included or excluded in various contexts. A discussion of the general principles regarding reporting of novel variants, challenging cases (genes for which consensus was difficult to achieve across Clinical Sequencing Exploratory Research network sites), solicitation of preferences from participants regarding return of incidental findings, and the timing and context of return of incidental findings are provided. PMID:24195999

  4. St. Jude researchers find that an inherited gene variation leaves young leukemia patients at risk for peripheral neuropathy

    Cancer.gov

    Research led by St. Jude Children’s Research Hospital investigators could help reduce side effects associated with the anti-cancer drug vincristine, which is widely used to treat cancer in children and adults.

  5. UK Full-Scale Non-Active vitrification development and implementation of research findings onto the waste vitrification plant

    SciTech Connect

    Bradshaw, K.; Gribble, N.R. [Nexia Solutions, Sellafield, Seascale, CA (United Kingdom); Hughes, D.O.; Riley, A.D. [British Nuclear Group, Sellafield, Seascale, CA (United Kingdom)

    2007-07-01

    This paper describes the historic and current status of inactive research in support of UK Highly Active (HA) waste vitrification. Experimental work performed to date on the UK's inactive vitrification research facility is summarised along with estimates of the potential impact of this research work on the reduction of HA Liquor (HAL) stocks stored in the UK at Sellafield. The current position regarding implementation of research learning onto the UK's operational vitrification plants is described. (authors)

  6. Ambient Particulate Matter during MILAGRO in Mexico City: Main Findings, Impacts (on AQ and Climate), and Future Research Needs

    NASA Astrophysics Data System (ADS)

    Jimenez, Jose-Luis; Schauer, James J.; Molina, Luisa T.; MILAGRO Pm Team

    2010-05-01

    The MILAGRO campaign was a large international field experiments conduced in Mexico City and Central Mexico during March 2006. We present an overview of the main findings related to particulate matter and aerosol radiative properties. PM levels inside Mexico City were similar or higher than those in the most polluted North American cities, but ~5 times lower than levels in the most polluted Asian megacities During the study, PM10 and PM2.5 concentrations in the urban area of were about double the concentrations in the rural areas surrounding Mexico City. PM2.5 made up about half of the PM10 concentrations, with small amounts of mass in the PM2.5-PM1.0 range. Mineral matter made up approximately 25% of the PM10 and on average 15% and 28% of the PM2.5 in the urban and rural areas, respectively. Approximately 25% of the PM2.5 was secondary inorganic ions with the remaining PM2.5 mass being comprised of largely carbonaceous aerosol. Except for surface measurements at the central sampling sites in Mexico city, the elemental carbon mass absorption efficiency was relatively constant for aircraft and surface measurements throughout the study, contrary to expectations. Although different organic aerosol (OA) source apportionment methods had some differences, there was agreement that the dominant sources of carbonaceous aerosol were secondary OA (SOA), biomass burning, and mobile sources. The impact of biomass burning to the aerosol outflow from the region was much larger than to the surface concentrations inside the city. SOA formation from primary semivolatile and intermediate volatility precursors has the potential to close the gap in predicted vs. measured SOA, while formation from glyoxal also makes an important contribution, especially to organic oxygen. Biogenic SOA advected from the coastal mountain ranges contributes about 1 ?g m-3 to concentrations in the MCMA. Primary OA from anthropogenic and biomass burning sources was found to be semivolatile, while secondary OA was less volatile than POA and aged SOA was essentially non-volatile, in contradiction with current models. Growth rates of new particle formation in Mexico City was very large and found to be impacted by nitrogen containing organic compounds, organic acids, and hydroxyl organic acids, with only a smaller fraction of sulfate aerosol. Some open research questions include the following: additional work is needed to fully quantify the sources of substantial (30-45%) modern carbon in organic aerosols during low biomass burning periods. Discrepancies between the two modern carbon datasets deserve further study. The impact of regional dust vs. road resuspension, as well as heterogeneous reactions of HNO3 with dust need to be quantified. The impact of some POA sources such as food cooking, biofuel use, and open trash burning may be important, but remains poorly characterized. Some differences in the apportionment of biomass burning PM between different approaches were observed and need further research, as these techniques together represent the state of the art for source apportionment. Anthropogenic SOA predictions are improving in terms of magnitude but are poorly constrained by the data. More specific precursor, intermediate, and tracer measurements are needed in future campaigns. SOA from biomass burning sources, although not dominant in the city, remains poorly characterized and appears to be underpredicted by traditional models.

  7. Landfill aeration worldwide: Concepts, indications and findings

    SciTech Connect

    Ritzkowski, M., E-mail: m.ritzkowski@tu-harburg.de [Institute of Environmental Technology and Energy Economics, Hamburg University of Technology, Harburger Schlossstr. 36, 21079 Hamburg (Germany); Stegmann, R., E-mail: info@ifas-hamburg.de [Consultants for Waste Management, Prof. R. Stegmann and Partner, Schellerdamm 19-21, 21079 Hamburg (Germany)

    2012-07-15

    Highlights: Black-Right-Pointing-Pointer Different landfill aeration concepts and accordant application areas are described. Black-Right-Pointing-Pointer Examples of full scale projects are provided for Europe, North-America and Asia. Black-Right-Pointing-Pointer Major project findings are summarised, including prospects and limitations. Black-Right-Pointing-Pointer Inconsistencies between laboratory and full scale results have been elaborated. Black-Right-Pointing-Pointer An explanatory approach in connection with the inconsistencies is provided. - Abstract: The creation of sustainable landfills is a fundamental goal in waste management worldwide. In this connection landfill aeration contributes towards an accelerated, controlled and sustainable conversion of conventional anaerobic landfills into a biological stabilized state associated with a minimised emission potential. The technology has been successfully applied to landfills in Europe, North America and Asia, following different strategies depending on the geographical region, the specific legislation and the available financial resources. Furthermore, methodologies for the incorporation of landfill aeration into the carbon trade mechanisms have been developed in recent years. This manuscript gives an overview on existing concepts for landfill aeration; their application ranges and specifications. For all of the described concepts examples from different countries worldwide are provided, including details regarding their potentials and limitations. Some of the most important findings from these aeration projects are summarised and future research needs have been identified. It becomes apparent that there is a great demand for a systematisation of the available results and implications in order to further develop and optimise this very promising technology. The IWWG (International Waste Working Group) Task Group 'Landfill Aeration' contributes towards the achievement of this goal.

  8. NCI: SBIR & STTR - Find Funding - Contracts - 249 System to Analyze and Support Biomarker Research and Development Strategies

    Cancer.gov

    Because of the rapid expansion of the worldwide biomarker research data in volume and breadth, there is a critical need for integrating all of these data within a knowledge management system that supports automated review and evaluation of current research and development efforts, particularly within the context of all cancer research and therapeutic and diagnostic product development. Such a system permits rapid identification and decision-making to allocate resources where they can most efficiently be used to enhance product development.

  9. Phage-Finding Using Mycobacteria: A Secondary School or Undergraduate Research Module with the Potential to Gain Scientific Authorship

    ERIC Educational Resources Information Center

    Schwebach, James Reid; Jacobs, William R., Jr.

    2006-01-01

    Mycobacteriophages are in the limelight of biomedical science (Pedulla et al., 2003), and new phage can be discovered and studied in a variety of high school and undergraduate educational settings. Simple methods for finding and studying new mycobacteriophage are described.

  10. Detection and correction of inconsistency-based errors in non-rigid registration

    NASA Astrophysics Data System (ADS)

    Gass, Tobias; Szekely, Gabor; Goksel, Orcun

    2014-03-01

    In this paper we present a novel post-processing technique to detect and correct inconsistency-based errors in non-rigid registration. While deformable registration is ubiquitous in medical image computing, assessing its quality has yet been an open problem. We propose a method that predicts local registration errors of existing pairwise registrations between a set of images, while simultaneously estimating corrected registrations. In the solution the error is constrained to be small in areas of high post-registration image similarity, while local registrations are constrained to be consistent between direct and indirect registration paths. The latter is a critical property of an ideal registration process, and has been frequently used to asses the performance of registration algorithms. In our work, the consistency is used as a target criterion, for which we efficiently find a solution using a linear least-squares model on a coarse grid of registration control points. We show experimentally that the local errors estimated by our algorithm correlate strongly with true registration errors in experiments with known, dense ground-truth deformations. Additionally, the estimated corrected registrations consistently improve over the initial registrations in terms of average deformation error or TRE for different registration algorithms on both simulated and clinical data, independent of modality (MRI/CT), dimensionality (2D/3D) and employed primary registration method (demons/Markov-randomfield).

  11. Breathtaking advances begin with outstanding people from researchers determined to find cures to healthcare providers who deliver extraordinary care to

    E-print Network

    Chapman, Michael S.

    experts to OHSU. These clinicians and researchers have helped OHSU earn a reputation as a world leader and technologies, hundreds of research studies and approximately 400 clinical trials, the OHSU Knight Cancer the more than 650 doctors, nurses, scientists and staff who work together at the Knight to reduce

  12. Learning and Organization in the Knowledge-Based Information Economy: Initial Findings from a Participatory Action Research Case Study

    Microsoft Academic Search

    Richard T. Harrison; Claire M. Leitch

    2000-01-01

    This paper reports on an ongoing, multiphase, project-based action learning and research project. In particular, it summarizes some aspects of the learning climate and outcomes for a case-study company in the software industry. Using a participatory action research approach, the learning company framework developed by Pedler et al. (1997) is used to initiate critical reflection in the company at three

  13. St. Jude researchers find that measuring treatment response proves to be a powerful tool for guiding leukemia treatment

    Cancer.gov

    Measuring the concentration of leukemia cells in patient bone marrow during the first 46 days of chemotherapy should help boost survival of young leukemia patients by better matching patients with the right intensity of chemotherapy. St. Jude Children's Research Hospital investigators led the research, which appears in the March 20 edition of the journal Lancet Oncology.

  14. Procedures of recruiting, obtaining informed consent, and compensating research participants in Qatar: findings from a qualitative investigation

    PubMed Central

    2014-01-01

    Background Very few researchers have reported on procedures of recruiting, obtaining informed consent, and compensating participants in health research in the Arabian Gulf Region. Empirical research can inform the debate about whether to adjust these procedures for culturally diverse settings. Our objective was to delineate procedures related to recruiting, obtaining informed consent, and compensating health research participants in the extremely high-density multicultural setting of Qatar. Methods During a multistage mixed methods project, field observations and qualitative interviews were conducted in a general medicine clinic of a major medical center in Qatar. Participants were chosen based on gender, age, literacy, and preferred language, i.e., Arabic, English, Hindi and Urdu. Qualitative analysis identified themes about recruitment, informed consent, compensation, and other research procedures. Results A total of 153 individuals were approached and 84 enrolled; the latter showed a diverse age range (18 to 75 years); varied language representation: Arabic (n?=?24), English (n?=?20), Hindi (n?=?20), and Urdu (n?=?20); and balanced gender distribution: women (n?=?43) and men (n?=?41). Primary reasons for 30 declinations included concern about interview length and recording. The study achieved a 74% participation rate. Qualitative analytics revealed key themes about hesitation to participate, decisions about participation with family members as well as discussions with them as “incidental research participants”, the informed consent process, privacy and gender rules of the interview environment, reactions to member checking and compensation, and motivation for participating. Vulnerability emerged as a recurring issue throughout the process among a minority of participants. Conclusions This study from Qatar is the first to provide empirical data on recruitment, informed consent, compensation and other research procedures in a general adult population in the Middle East and Arabian Gulf. This investigation illustrates how potential research participants perceive research participation. Fundamentally, Western ethical research principles were applicable, but required flexibility and culturally informed adaptations. PMID:24495499

  15. Research Trends and Findings From a Decade (1997–2007) of Research on Informal Science Education and Free-Choice Science Learning

    Microsoft Academic Search

    Molly Phipps

    2010-01-01

    The decade from 1997–2007 was transformative for research into science learning in out-of-school contexts. The field transitioned from being driven by individual programmatic needs into a field with a coherent conceptual framework to guide research. These changes are documented in the research published in International Journal of Science Education, Science Education, and Journal of Research in Science Teaching, 3 major

  16. Integration of Research and Practice in Substance Use Disorder Treatment: Findings from Focus Groups of Clinicians, Researchers, Educators, Administrators, and Policy Makers

    ERIC Educational Resources Information Center

    Campbell, Todd C.; Daood, Christopher; Catlin, Lynn; Abelson, Alissa

    2005-01-01

    Clinicians, researchers, educators, administrators, and policy makers, who represented stakeholders in the substance abuse treatment field, participated in 5 focus groups. Four general areas regarding integration of research and practice were investigated: definition of research, training/education, current integration, and future integration.…

  17. Consulting communities on feedback of genetic findings in international health research: sharing sickle cell disease and carrier information in coastal Kenya

    PubMed Central

    2013-01-01

    Background International health research in malaria-endemic settings may include screening for sickle cell disease, given the relationship between this important genetic condition and resistance to malaria, generating questions about whether and how findings should be disclosed. The literature on disclosing genetic findings in the context of research highlights the role of community consultation in understanding and balancing ethically important issues from participants’ perspectives, including social forms of benefit and harm, and the influence of access to care. To inform research practice locally, and contribute to policy more widely, this study aimed to explore the views of local residents in Kilifi County in coastal Kenya on how researchers should manage study-generated information on sickle cell disease and carrier status. Methods Between June 2010 and July 2011, we consulted 62 purposively selected Kilifi residents on how researchers should manage study-generated sickle cell disease findings. Methods drew on a series of deliberative informed small group discussions. Data were analysed thematically, using charts, to describe participants’ perceptions of the importance of disclosing findings, including reasoning, difference and underlying values. Themes were derived from the underlying research questions and from issues emerging from discussions. Data interpretation drew on relevant areas of social science and bioethics literature. Results Perceived health and social benefits generated strong support for disclosing findings on sickle cell disease, but the balance of social benefits and harms was less clear for sickle cell trait. Many forms of health and social benefits and harms of information-sharing were identified, with important underlying values related to family interests and the importance of openness. The influence of micro and macro level contextual features and prioritization of values led to marked diversity of opinion. Conclusions The approach demonstrates a high ethical importance in many malaria endemic low-to-middle income country settings of disclosing sickle cell disease findings generated during research, alongside provision of effective care and locally-informed counselling. Since these services are central to the benefits of disclosure, health researchers whose studies include screening for sickle cell disease should actively promote the development of health policy and services for this condition in situations of unmet need, including through the prior development of collaborative partnerships with government health managers and providers. Community consultation can importantly enrich ethical debate on research practice where in-depth exploration of informed views and the potential for difference are taken into account. PMID:24125465

  18. Who Has Used Internal Company Documents for Biomedical and Public Health Research and Where Did They Find Them?

    PubMed Central

    Wieland, L. Susan; Rutkow, Lainie; Vedula, S. Swaroop; Kaufmann, Christopher N.; Rosman, Lori M.; Twose, Claire; Mahendraratnam, Nirosha; Dickersin, Kay

    2014-01-01

    Objective To describe the sources of internal company documents used in public health and healthcare research. Methods We searched PubMed and Embase for articles using internal company documents to address a research question about a health-related topic. Our primary interest was where authors obtained internal company documents for their research. We also extracted information on type of company, type of research question, type of internal documents, and funding source. Results Our searches identified 9,305 citations of which 357 were eligible. Scanning of reference lists and consultation with colleagues identified 4 additional articles, resulting in 361 included articles. Most articles examined internal tobacco company documents (325/361; 90%). Articles using documents from pharmaceutical companies (20/361; 6%) were the next most common. Tobacco articles used documents from repositories; pharmaceutical documents were from a range of sources. Most included articles relied upon internal company documents obtained through litigation (350/361; 97%). The research questions posed were primarily about company strategies to promote or position the company and its products (326/361; 90%). Most articles (346/361; 96%) used information from miscellaneous documents such as memos or letters, or from unspecified types of documents. When explicit information about study funding was provided (290/361 articles), the most common source was the US-based National Cancer Institute. We developed an alternative and more sensitive search targeted at identifying additional research articles using internal pharmaceutical company documents, but the search retrieved an impractical number of citations for review. Conclusions Internal company documents provide an excellent source of information on health topics (e.g., corporate behavior, study data) exemplified by articles based on tobacco industry documents. Pharmaceutical and other industry documents appear to have been less used for research, indicating a need for funding for this type of research and well-indexed and curated repositories to provide researchers with ready access to the documents. PMID:24800999

  19. A training programme to build cancer research capacity in low- and middle-income countries: findings from Guatemala

    PubMed Central

    Barnoya, Joaquin; Gharzouzi, Eduardo N; Benson, Peter; Colditz, Graham A

    2014-01-01

    Abstract Problem Guatemala is experiencing an increasing burden of cancer but lacks capacity for cancer prevention, control and research. Approach In partnership with a medical school in the United States of America, a multidisciplinary Cancer Control Research Training Institute was developed at the Instituto de Cancerología (INCAN) in Guatemala City. This institute provided a year-long training programme for clinicians that focused on research methods in population health and sociocultural anthropology. The programme included didactic experiences in Guatemala and the United States as well as applied training in which participants developed research protocols responsive to Guatemala’s cancer needs. Local setting Although INCAN is the point of referral and service for Guatemala’s cancer patients, the institute’s administration is also interested in increasing cancer research – with a focus on population health. INCAN is thus a resource for capacity building within the context of cancer prevention and control. Relevant changes Trainees increased their self-efficacy for the design and conduct of research. Value-added benefits included establishment of an annual cancer seminar and workshops in cancer pathology and qualitative analysis. INCAN has recently incorporated some of the programme’s components into its residency training and established a research department. Lessons learnt A training programme for clinicians can build cancer research capacity in low- and middle-income countries. Training in population-based research methods will enable countries such as Guatemala to gather country-specific data. Once collected, such data can be used to assess the burden of cancer-related disease, guide policy for reducing it and identify priority areas for cancer prevention and treatment. PMID:24700998

  20. Biomimetics for NASA Langley Research Center: Year 2000 Report of Findings From a Six-Month Survey

    NASA Technical Reports Server (NTRS)

    Siochi, Emilie J.; Anders, John B., Jr.; Cox, David E.; Jegley, Dawn C.; Fox, Robert L.; Katzberg, Stephen J.

    2002-01-01

    This report represents an attempt to see if some of the techniques biological systems use to maximize their efficiency can be applied to the problems NASA faces in aeronautics and space exploration. It includes an internal survey of resources available at NASA Langley Research Center for biomimetics research efforts, an external survey of state of the art in biomimetics covering the Materials, Structures, Aerodynamics, Guidance and Controls areas. The Biomimetics Planning team also included ideas for potential research areas, as well as recommendations on how to implement this new program. This six-month survey was conducted in the second half of 1999.