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Sample records for instrument voor het

  1. The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility

    PubMed Central

    Seuring, Carolin; Greenwald, Jason; Wasmer, Christian; Wepf, Roger; Saupe, Sven J.; Meier, Beat H.; Riek, Roland

    2012-01-01

    The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a cell death reaction termed heterokaryon incompatibility. This reaction is observed at the point of contact between two genetically distinct strains when one harbors a HET-s prion (in the form of amyloid aggregates) and the other expresses a soluble HET-S protein (96% identical to HET-s). How the HET-s prion interaction with HET-S brings about cell death remains unknown; however, it was recently shown that this interaction leads to a relocalization of HET-S from the cytoplasm to the cell periphery and that this change is associated with cell death. Here, we present detailed insights into this mechanism in which a non-toxic HET-s prion converts a soluble HET-S protein into an integral membrane protein that destabilizes membranes. We observed liposomal membrane defects of approximately 10 up to 60 nm in size in transmission electron microscopy images of freeze-fractured proteoliposomes that were formed in mixtures of HET-S and HET-s amyloids. In liposome leakage assays, HET-S has an innate ability to associate with and disrupt lipid membranes and that this activity is greatly enhanced when HET-S is exposed to HET-s amyloids. Solid-state nuclear magnetic resonance (NMR) analyses revealed that HET-s induces the prion-forming domain of HET-S to adopt the β-solenoid fold (previously observed in HET-s) and this change disrupts the globular HeLo domain. These data indicate that upon interaction with a HET-s prion, the HET-S HeLo domain partially unfolds, thereby exposing a previously buried ∼34-residue N-terminal transmembrane segment. The liberation of this segment targets HET-S to the membrane where it further oligomerizes, leading to a loss of membrane integrity. HET-S thus appears to display features that are reminiscent of pore-forming toxins. PMID:23300377

  2. HET Spectroscopy of Extragalactic Novae

    NASA Astrophysics Data System (ADS)

    Shafter, Allen W.; Coelho, E. A.; Misselt, K. A.; Bode, M. F.; Darnley, M. J.

    2006-12-01

    We are currently involved in a multifaceted campaign to study extragalactic novae in the optical and IR using a variety of instruments: The Mount Laguna 1m, the Steward 2.3m, and the Liverpool 2m telescopes for optical imaging, the Hobbey-Eberly Telescope (HET) for optical spectroscopy, and the Spitzer Space Telescope for IR photometry and spectroscopy. Here, we report the initial results from our program of spectroscopic observations obtained with the LRS on the HET. Thus far, we have obtained spectra of three novae: Nova M31-2006#9 (ATEL 887), Nova M32-2006#1 (CBET 591), and Nova M33-2006#1 (CBET 655), which were taken on 24-Sep-2006 UT, 30-Sep-2006 UT, and 02-Oct-2006 UT, approximately 6, 65, and 4 days post discovery, for the three novae respectively. The spectra of Nova M31-2006#9 and Nova M33-2006#1 revealed prominent Balmer (FWHM 1600 km/s) and Fe II emission lines typical of the "Fe II" class in the classification system of Williams (1992 AJ, 104, 725). The spectrum of Nova M32-2006#1, which was obtained much longer after eruption, showed strong H-alpha (FWHM 1300 km/s), along with weaker H-beta, Fe II, and [N II] 5755, indicating that this nova is also a member of the Fe II class, and that it had entered the nebular phase at the time of our observations. In addition to these three novae, we also attempted to obtain a spectrum of Nova M31-2006#7 (CBET 615) on 23-Sep-2006 UT, approximately three weeks after discovery. However, by the time of our observations, the nova had faded to invisibility. An 1800s integration at the reported position reveled no trace of the nova. It is likely that this optical transient was an unusually fast nova, possibly of the "He/N" class. This work is being supported in part by NSF grant AST-0607682.

  3. Interacting with the HET Queue

    NASA Astrophysics Data System (ADS)

    Gaffney, N. I.; Cornell, M. E.

    1998-12-01

    The Hobby*Eberly telescope (HET) is a 9.2m effective aperture telescope located at McDonald Observatory in West Texas. The HET is operated by McDonald Observatory on behalf of the University of Texas, Pennsylvania State University, Stanford University, Ludsiwg--Maximilians--Universitat Muchen, and Georg-August-Universitat Gotingen. The fixed elevation of the HET restricts its sky coverage. Because the HET cannot point to all objects above the horizon at a given time, it is usually inefficient to schedule observations by awarding entire nights to a single PI. To maximize scientific output, we have developed a queued observing system to allow PIs to instruct resident astronomers at the HET how, when, and what to observe. Our system uses the now familiar Phase I/II architecture for requesting and submitting remote observations with a real time scheduling system for scheduling and executing observations. During Phase I, the PI uses simple planning tools to determine if and how a project may be done. Once projects are approved by a TAC at a partner institution, the PI creates a detailed plan for their observations. Plans are submitted electronically to the HET operations staff. Upon receipt, the plans are integrated into the HET's observing database. Resident astronomers use this database and the current and forecasted conditions to schedule observations. PIs are informed of new data by e-mail and may retrieve data to verify its quality in semi-realtime. PIs may make changes to their plans based on this data. In this poster we will discuss the flow of information from the initial proposal phase through the delivery of data and plan revision. We will talk about some of the details of the planning and scheduling software developed for this project. We will also discuss the results of our initial experience with our system in the Fall and Winter of 1998.

  4. Theme and variations: evolutionary diversification of the HET-s functional amyloid motif

    PubMed Central

    Daskalov, Asen; Dyrka, Witold; Saupe, Sven J.

    2015-01-01

    In mammals and fungi, Nod-like receptors (NLR) activate downstream cell death execution proteins by a prion-like mechanism. In Podospora anserina, the NWD2 NLR activates the HET-S Helo-domain pore-forming protein by converting its prion-forming domain into a characteristic β-solenoid amyloid fold. The amyloid forming region of HET-S/s comprises two repetitions of a 21 amino acid motif. Herein, we systematically analyze the sequences of C-terminal regions of fungal HeLo and HeLo-like domain proteins to identify HET-s-related amyloid motifs (HRAM). We now identify four novel HRAM subfamilies in addition to the canonical HET-S/s subfamily. These novel motifs share the pseudo-repeat structure of HET-S/s and a specific pattern of distribution of hydrophobic and polar residues. Sequence co-variance analyses predict parallel in-register β-stacking of the two repeats and residue-residue interactions compatible with the β-solenoid fold. As described for HET-S, most genes encoding the HeLo proteins are adjacent to genes encoding NLRs also displaying HRAMs. The motifs of the NLRs are similar to those of their cognate HeLo-domain protein, indicating concerted evolution between repeats. This study shows that HET-s-related amyloid motifs are more common than anticipated and that they have diversified into discrete subfamilies that apparently share a common overall fold. PMID:26219477

  5. Op weg naar een didactiek voor natuurkunde-experimenten op afstand : Ontwerp en evaluatie van een via internet uitvoerbaar experiment voor leerlingen uit het voortgezet onderwijs

    NASA Astrophysics Data System (ADS)

    Engelbarts, M. B. A.

    2009-02-01

    The subject of this thesis is a developmental study on “remote experimenting” in education. It concerns the development of a remote experiment that enables pre-university students to carry out a physics experiment at a distance via the internet. Remote experiments can offer several (practical) benefits when compared to conventional experiments but the desire to exploit these benefits put special demands on the design of the experiment, since the students might be conducting the experiment without a teacher in the vicinity. As a consequence of these demands it was decided to focus on exploring the possibilities and problems of remote experiments conducted in the absence of a teacher. The research was carried out in two cycles and focused on the development of a remote experiment that could be conducted autonomously by pre-university students to measure the speed of light in several media. This should answer the global question: What should a technically, as well as didactically, well-functioning remote experiment look like? The first cycle had an explorative character. It showed that technically the experiment already functioned quite well. However, many problems were observed concerning the content, and the way the students were tackling it. This led to two categories of recommendations. Concerning the content, the material should aim at making the students more aware of what they are doing and why they are doing it and several content related problems needed to be avoided. The second category of recommendations concerned the format of the material: the design and the working method. Special attention should be paid to designing a clear structure for the website and adding interaction and control, (feedback- and reflection facilities) to activate the students and guide them through the material. In the second research cycle these recommendations were followed by designing the material within the theoretical framework of the problem posing theory. A didactical structure was designed before writing the actual lesson material for the website describing the inter-related conceptual and content-related motivational pathway of the intended teaching-learning process. The lesson material was set up in such a way that the students are repeatedly confronted with a practical problem to solve and they play an active role in developing the method of measurement. Secondly, in an attempt to compensate for the absence of the teacher and support the teaching-learning process some format elements were developed and deployed like an automated question-, and feedback system that supported the students, activated them and gave them insight into their learning process and a ‘Where-am-I’-window that showed their current position within the material. This all had led to a technically as well as didactically well functioning remote experiment in which, at a global level, the line of reasoning was made explicit and recognizable for the students, and ad a local level was build up out of well connected successive activities and required the students to adopt an active attitude.

  6. Origins and Evolution of the HET-s Prion-Forming Protein: Searching for Other Amyloid-Forming Solenoids

    PubMed Central

    Gendoo, Deena M. A.; Harrison, Paul M.

    2011-01-01

    The HET-s prion-forming domain from the filamentous fungus Podospora anserina is gaining considerable interest since it yielded the first well-defined atomic structure of a functional amyloid fibril. This structure has been identified as a left-handed beta solenoid with a triangular hydrophobic core. To delineate the origins of the HET-s prion-forming protein and to discover other amyloid-forming proteins, we searched for all homologs of the HET-s protein in a database of protein domains and fungal genomes, using a combined application of HMM, psi-blast and pGenThreader techniques, and performed a comparative evolutionary analysis of the N-terminal alpha-helical domain and the C-terminal prion-forming domain of HET-s. By assessing the tandem evolution of both domains, we observed that the prion-forming domain is restricted to Sordariomycetes, with a marginal additional sequence homolog in Arthroderma otae as a likely case of horizontal transfer. This suggests innovation and rapid evolution of the solenoid fold in the Sordariomycetes clade. In contrast, the N-terminal domain evolves at a slower rate (in Sordariomycetes) and spans many diverse clades of fungi. We performed a full three-dimensional protein threading analysis on all identified HET-s homologs against the HET-s solenoid fold, and present detailed structural annotations for identified structural homologs to the prion-forming domain. An analysis of the physicochemical characteristics in our set of structural models indicates that the HET-s solenoid shape can be readily adopted in these homologs, but that they are all less optimized for fibril formation than the P. anserina HET-s sequence itself, due chiefly to the presence of fewer asparagine ladders and salt bridges. Our combined structural and evolutionary analysis suggests that the HET-s shape has “limited scope” for amyloidosis across the wider protein universe, compared to the ‘generic’ left-handed beta helix. We discuss the implications of

  7. HET Spectra of Three Recent Extragalactic Novae

    NASA Astrophysics Data System (ADS)

    Shafter, A. W.; Coelho, E. A.; Misselt, K. A.; Bode, M. F.; Darnley, M. J.; Quimby, R.

    2006-10-01

    We report optical spectroscopic observations (4280Å - 7280Å) obtained with the HET of three extragalactic novae: Nova M31 2006 No. 9 (ATEL #887), Nova M32 2006 No. 1 (CBET #591), and Nova M33 2006 No. 1 (CBET #655). The spectra were obtained on 24 Sep 2006 UT, 30 Sep 2006 UT, and 02 Oct 2006 UT, corresponding to approximately 6, 65, and 4 days post discovery, for the three novae respectively.

  8. A yeast toxic mutant of HET-s amyloid disrupts membrane integrity.

    PubMed

    Ta, Ha Phuong; Berthelot, Karine; Coulary-Salin, Bénédicte; Castano, Sabine; Desbat, Bernard; Bonnafous, Pierre; Lambert, Olivier; Alves, Isabel; Cullin, Christophe; Lecomte, Sophie

    2012-09-01

    Many studies have pointed out the interaction between amyloids and membranes, and their potential involvement in amyloid toxicity. Previously, we generated a yeast toxic amyloid mutant (M8) from the harmless amyloid protein by changing a few residues of the Prion Forming Domain of HET-s (PFD HET-s(218-289)) and clearly demonstrated the complete different behaviors of the non-toxic Wild Type (WT) and toxic amyloid (called M8) in terms of fiber morphology, aggregation kinetics and secondary structure. In this study, we compared the interaction of both proteins (WT and M8) with membrane models, as liposomes or supported bilayers. We first demonstrated that the toxic protein (M8) induces a significant leakage of liposomes formed with negatively charged lipids and promotes the formation of microdomains inside the lipid bilayer (as potential "amyloid raft"), whereas the non-toxic amyloid (WT) only binds to the membrane without further perturbations. The secondary structure of both amyloids interacting with membrane is preserved, but the anti-symmetric PO(2)(-) vibration is strongly shifted in the presence of M8. Secondly, we established that the presence of membrane models catalyzes the amyloidogenesis of both proteins. Cryo-TEM (cryo-transmission electron microscopy) images show the formation of long HET-s fibers attached to liposomes, whereas a large aggregation of the toxic M8 seems to promote a membrane disruption. This study allows us to conclude that the toxicity of the M8 mutant could be due to its high propensity to interact and disrupt lipid membranes. PMID:22562024

  9. Natural Variation of Heterokaryon Incompatibility Gene het-c in Podospora anserina Reveals Diversifying Selection

    PubMed Central

    Bastiaans, Eric; Debets, Alfons J.M.; Aanen, Duur K.; van Diepeningen, Anne D.; Saupe, Sven J.; Paoletti, Mathieu

    2014-01-01

    In filamentous fungi, allorecognition takes the form of heterokaryon incompatibility, a cell death reaction triggered when genetically distinct hyphae fuse. Heterokaryon incompatibility is controlled by specific loci termed het-loci. In this article, we analyzed the natural variation in one such fungal allorecognition determinant, the het-c heterokaryon incompatibility locus of the filamentous ascomycete Podospora anserina. The het-c locus determines an allogenic incompatibility reaction together with two unlinked loci termed het-d and het-e. Each het-c allele is incompatible with a specific subset of the het-d and het-e alleles. We analyzed variability at the het-c locus in a population of 110 individuals, and in additional isolates from various localities. We identified a total of 11 het-c alleles, which define 7 distinct incompatibility specificity classes in combination with the known het-d and het-e alleles. We found that the het-c allorecognition gene of P. anserina is under diversifying selection. We find a highly unequal allele distribution of het-c in the population, which contrasts with the more balanced distribution of functional groups of het-c based on their allorecognition function. One explanation for the observed het-c diversity in the population is its function in allorecognition. However, alleles that are most efficient in allorecognition are rare. An alternative and not exclusive explanation for the observed diversity is that het-c is involved in pathogen recognition. In Arabidopsis thaliana, a homolog of het-c is a pathogen effector target, supporting this hypothesis. We hypothesize that the het-c diversity in P. anserina results from both its functions in pathogen-defense, and allorecognition. PMID:24448643

  10. Natural variation of heterokaryon incompatibility gene het-c in Podospora anserina reveals diversifying selection.

    PubMed

    Bastiaans, Eric; Debets, Alfons J M; Aanen, Duur K; van Diepeningen, Anne D; Saupe, Sven J; Paoletti, Mathieu

    2014-04-01

    In filamentous fungi, allorecognition takes the form of heterokaryon incompatibility, a cell death reaction triggered when genetically distinct hyphae fuse. Heterokaryon incompatibility is controlled by specific loci termed het-loci. In this article, we analyzed the natural variation in one such fungal allorecognition determinant, the het-c heterokaryon incompatibility locus of the filamentous ascomycete Podospora anserina. The het-c locus determines an allogenic incompatibility reaction together with two unlinked loci termed het-d and het-e. Each het-c allele is incompatible with a specific subset of the het-d and het-e alleles. We analyzed variability at the het-c locus in a population of 110 individuals, and in additional isolates from various localities. We identified a total of 11 het-c alleles, which define 7 distinct incompatibility specificity classes in combination with the known het-d and het-e alleles. We found that the het-c allorecognition gene of P. anserina is under diversifying selection. We find a highly unequal allele distribution of het-c in the population, which contrasts with the more balanced distribution of functional groups of het-c based on their allorecognition function. One explanation for the observed het-c diversity in the population is its function in allorecognition. However, alleles that are most efficient in allorecognition are rare. An alternative and not exclusive explanation for the observed diversity is that het-c is involved in pathogen recognition. In Arabidopsis thaliana, a homolog of het-c is a pathogen effector target, supporting this hypothesis. We hypothesize that the het-c diversity in P. anserina results from both its functions in pathogen-defense, and allorecognition. PMID:24448643

  11. Performance verification testing for HET wide-field upgrade tracker in the laboratory

    NASA Astrophysics Data System (ADS)

    Good, John; Hayes, Richard; Beno, Joseph; Booth, John; Cornell, Mark E.; Hill, Gary J.; Lee, Hanshin; Mock, Jason; Rafal, Marc; Savage, Richard; Soukup, Ian

    2010-07-01

    To enable the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX), the McDonald Observatory (MDO) and the Center for Electro-mechanics (CEM) at the University of Texas at Austin are developing a new HET tracker in support of the Wide-Field Upgrade (WFU) and the Visible Integral-Field Replicable Unit Spectrograph (VIRUS). The precision tracker is required to maintain the position of a 3,100 kg payload within ten microns of its desired position relative to the telescope's primary mirror. The hardware system to accomplish this has ten precision controlled actuators. Prior to installation on the telescope, full performance verification is required of the completed tracker in CEM's lab, without a primary mirror or the telescope's final instrument package. This requires the development of a laboratory test stand capable of supporting the completed tracker over its full range of motion, as well as means of measurement and methodology that can verify the accuracy of the tracker motion over full travel (4m diameter circle, 400 mm deep, with 9 degrees of tip and tilt) at a cost and schedule in keeping with the HET WFU requirements. Several techniques have been evaluated to complete this series of tests including: photogrammetry, laser tracker, autocollimator, and a distance measuring interferometer, with the laser tracker ultimately being identified as the most viable method. The design of the proposed system and its implementation in the lab is presented along with the test processes, predicted accuracy, and the basis for using the chosen method*.

  12. Design, testing, and performance of the Hobby Eberly Telescope prime focus instrument package

    NASA Astrophysics Data System (ADS)

    Vattiat, Brian; Hill, Gary J.; Lee, Hanshin; Perry, Dave M.; Rafal, Marc D.; Rafferty, Tom; Savage, Richard; Taylor, Charles A.; Moreira, Walter; Smith, Michael

    2012-09-01

    The Hobby-Eberly Telescope (HET) is undergoing an upgrade to increase the field of view to 22 arc-minutes with the dark energy survey HETDEX the initial science goal [1]. Here we report on the engineering development of a suite of instruments located at prime focus of the upgraded HET. The Prime Focus Instrument Package (PFIP) contains acquisition, guiding, and wave front sensing instrumentation [2], the fiber feeds for the facility spectrographs (VIRUS, HRS, MRS, LRS2), and ancillary hardware. This paper reviews the design and functions of the PFIP and presents details of the mechanical design, integration and testing.

  13. A Yeast Toxic Mutant of HET-s(218-289) Prion Displays Alternative Intermediates of Amyloidogenesis

    PubMed Central

    Berthelot, Karine; Lecomte, Sophie; Géan, Julie; Immel, Françoise; Cullin, Christophe

    2010-01-01

    Amyloids are thought to be involved in various types of neurodegenerative disorders. Several kinds of intermediates, differing in morphology, size, and toxicity, have been identified in the multistep amyloidogenesis process. However, the mechanisms explaining amyloid toxicity remain unclear. We previously generated a toxic mutant of the nontoxic HET-s(218-289) amyloid in yeast. Here we report that toxic and nontoxic amyloids differ not only in their structures but also in their assembling process. We used multiple and complementary methods to investigate the intermediates formed by these two amyloids. With the methods used, no intermediates were observed for the nontoxic amyloid; however, under the same experimental conditions, the toxic mutant displayed visible oligomeric and fibrillar intermediates. PMID:20713008

  14. LRS2: A New Integral Field Spectrograph for the HET

    NASA Astrophysics Data System (ADS)

    Tuttle, Sarah E.; Hill, Gary J.; Chonis, Taylor S.; Tonnesen, Stephanie

    2016-01-01

    Here we present LRS2 (Low Resolution Spectrograph) and highlight early science opportunities with the newly upgraded Hobby Eberly telescope (HET). LRS2 is a four-channel optical wavelength (370nm - 1micron) spectrograph based on two VIRUS unit spectrographs. This fiber-fed integral field spectrograph covers a 12" x 6" field of view, switched between the two units (one blue, and one red) at R~2000. We highlight design elements, including the fundamental modification to grisms (from VPH gratings in VIRUS) to access the higher resolution. We discuss early science opportunities, including investigating nearby "blue-bulge" spiral galaxies and their anomalous star formation distribution.

  15. Fiber Diffraction of the Prion-Forming Domain HET-s(218-289) Shows Dehydration-Induced Deformation of a Complex Amyloid Structure

    SciTech Connect

    Wan, William; Stubbs, Gerald

    2014-05-01

    Amyloids are filamentous protein aggregates that can be formed by many different proteins and are associated with both disease and biological functions. The pathogenicities or biological functions of amyloids are determined by their particular molecular structures, making accurate structural models a requirement for understanding their biological effects. One potential factor that can affect amyloid structures is hydration. Previous studies of simple stacked β-sheet amyloids have suggested that dehydration does not impact structure, but other studies indicated dehydration-related structural changes of a putative water-filled nanotube. Our results show that dehydration significantly affects the molecular structure of the fungal prion-forming domain HET-s(218–289), which forms a β-solenoid with no internal solvent-accessible regions. The dehydration-related structural deformation of HET-s(218–289) indicates that water can play a significant role in complex amyloid structures, even when no obvious water-accessible cavities are present.

  16. Identification of the het-r vegetative incompatibility gene of Podospora anserina as a member of the fast evolving HNWD gene family.

    PubMed

    Chevanne, Damien; Bastiaans, Eric; Debets, Alfons; Saupe, Sven J; Clavé, Corinne; Paoletti, Mathieu

    2009-02-01

    In fungi, vegetative incompatibility is a conspecific non-self recognition mechanism that restricts formation of viable heterokaryons when incompatible alleles of specific het loci interact. In Podospora anserina, three non-allelic incompatibility systems have been genetically defined involving interactions between het-c and het-d, het-c and het-e, het-r and het-v. het-d and het-e are paralogues belonging to the HNWD gene family that encode proteins of the STAND class. HET-D and HET-E proteins comprise an N-terminal HET effector domain, a central GTP binding site and a C-terminal WD repeat domain constituted of tandem repeats of highly conserved WD40 repeat units that define the specificity of alleles during incompatibility. The WD40 repeat units of the members of this HNWD family are undergoing concerted evolution. By combining genetic analysis and gain of function experiments, we demonstrate that an additional member of this family, HNWD2, corresponds to the het-r non-allelic incompatibility gene. As for het-d and het-e, allele specificity at the het-r locus is determined by the WD repeat domain. Natural isolates show allelic variation for het-r. PMID:19137300

  17. Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria.

    SciTech Connect

    Kim, Y.; Joachimiak, G.; Ye, Z.; Binkowski, T; Zhang, R.; Gornicki, P.; Callahan, S.; Hess, W.; Haselkorn, R.; Joachimiak, A.

    2011-06-21

    HetR is an essential regulator of heterocyst development in cyanobacteria. HetR binds to a DNA palindrome upstream of the hetP gene. We report the crystal structure of HetR from Fischerella at 3.0 {angstrom}. The protein is a dimer comprised of a central DNA-binding unit containing the N-terminal regions of the two subunits organized with two helix-turn-helix motifs; two globular flaps extending in opposite directions; and a hood over the central core formed from the C-terminal subdomains. The flaps and hood have no structural precedent in the protein database, therefore representing new folds. The structural assignments are supported by site-directed mutagenesis and DNA-binding studies. We suggest that HetR serves as a scaffold for assembly of transcription components critical for heterocyst development.

  18. Heterogeneous Seeding of a Prion Structure by a Generic Amyloid Form of the Fungal Prion-forming Domain HET-s(218-289)

    SciTech Connect

    Wan, William; Bian, Wen; McDonald, Michele; Kijac, Aleksandra; Wemmer, David E.; Stubbs, Gerald

    2013-11-13

    The fungal prion-forming domain HET-s(218–289) forms infectious amyloid fibrils at physiological pH that were shown by solid-state NMR to be assemblies of a two-rung β-solenoid structure. Under acidic conditions, HET-s(218–289) has been shown to form amyloid fibrils that have very low infectivity in vivo, but structural information about these fibrils has been very limited. We show by x-ray fiber diffraction that the HET-s(218–289) fibrils formed under acidic conditions have a stacked β-sheet architecture commonly found in short amyloidogenic peptides and denatured protein aggregates. At physiological pH, stacked β-sheet fibrils nucleate the formation of the infectious β-solenoid prions in a process of heterogeneous seeding, but do so with kinetic profiles distinct from those of spontaneous or homogeneous (seeded with infectious β-solenoid fibrils) fibrillization. Several serial passages of stacked β-sheet-seeded solutions lead to fibrillization kinetics similar to homogeneously seeded solutions. Our results directly show that structural mutation can occur between substantially different amyloid architectures, lending credence to the suggestion that the processes of strain adaptation and crossing species barriers are facilitated by structural mutation.

  19. Vestibular responses to linear acceleration are absent in otoconia-deficient C57BL/6JEi-het mice

    NASA Technical Reports Server (NTRS)

    Jones, S. M.; Erway, L. C.; Bergstrom, R. A.; Schimenti, J. C.; Jones, T. A.

    1999-01-01

    Vestibular evoked potentials (VsEPs) were measured in normal mice and in mice homozygous for the head tilt mutation (het/het, abbr. het). The het mice lack otoconia, the inertial mass critical for natural stimulation of inner ear gravity receptors. Our findings demonstrate that vestibular neural responses to pulsed linear acceleration are absent in het mice. The results: (1) confirm that adequate sensory stimuli fail to activate gravity receptors in the het model; and (2) serve as definitive evidence that far-field vestibular responses to pulsed linear acceleration depend critically on otolith end organs. The C57BL/6JEi-het mouse may be an excellent model of gravity receptor sensory deprivation.

  20. Expanding the Direct HetR Regulon in Anabaena sp. Strain PCC 7120

    PubMed Central

    Videau, Patrick; Ni, Shuisong; Rivers, Orion S.; Ushijima, Blake; Feldmann, Erik A.; Cozy, Loralyn M.; Kennedy, Michael A.

    2014-01-01

    In response to a lack of environmental combined nitrogen, the filamentous cyanobacterium Anabaena sp. strain PCC 7120 differentiates nitrogen-fixing heterocyst cells in a periodic pattern. HetR is a transcription factor that coordinates the regulation of this developmental program. An inverted repeat-containing sequence in the hepA promoter required for proheterocyst-specific transcription was identified based on sequence similarity to a previously characterized binding site for HetR in the promoter of hetP. The binding affinity of HetR for the hepA site is roughly an order of magnitude lower than that for the hetP binding site. A BLAST search of the Anabaena genome identified 166 hepA-like sites that occur as single or tandem sites (two binding sites separated by 13 bp). The vast majority of these sites are present in predicted intergenic regions. HetR bound five representative single binding sites in vitro, and binding was abrogated by transversions in the binding sites that conserved the inverted repeat nature of the sites. Binding to four representative tandem sites was not observed. Transcriptional fusions of the green fluorescent protein gene gfp with putative promoter regions associated with the representative binding sites indicated that HetR could function as either an activator or repressor and that activation was cell-type specific. Taken together, we have expanded the direct HetR regulon and propose a model in which three categories of HetR binding sites, based on binding affinity and nucleotide sequence, contribute to three of the four phases of differentiation. PMID:24375104

  1. SALT/HET cooperation in education and public outreach

    NASA Astrophysics Data System (ADS)

    Hemenway, Mary Kay; Preston, Sandra

    The "Science with SALT" meeting in March 1998 opened avenues of cooperation between SAAO and the University of Texas at Austin in education and public outreach. This paper will review past interactions and future plans. SAAO personnel have visited the HET and McDonald Observatory and have taken part in planning meetings for the Texas Astronomy Education Center museum area and educational programming. Discussions concerning the extension of the daily radio show StarDate (English), Universo (Spanish) and Sternzeit (German) versions to a southern hemisphere version are underway. In addition, we are cooperatively planning a workshop to discuss an international collaborative for educational outreach for state-of-the-art telescopes for which a regional collaborative in southwestern U.S. (SCOPE) serves as a model. The towns of Sutherland and Fort Davis are discussing forming a "twin-town" relationship. Projects and plans that link cutting-edge astronomical research to classrooms and the public will be reviewed.

  2. Escape from Het-6 Incompatibility in Neurospora Crassa Partial Diploids Involves Preferential Deletion within the Ectopic Segment

    PubMed Central

    Smith, M. L.; Yang, C. J.; Metzenberg, R. L.; Glass, N. L.

    1996-01-01

    Self-incompatible het-6(OR)/het-6(PA) partial diploids of Neurospora crassa were selected from a cross involving the translocation strain, T(IIL -> IIIR)AR18, and a normal sequence strain. About 25% of the partial diploids exhibited a marked increase in growth rate after 2 weeks, indicating that ``escape'' from het-6 incompatibility had occurred. Near isogenic tester strains with different alleles (het-6(OR) and het-6(PA)) were constructed and used to determine that 80 of 96 escape strains tested were het-6(PA), retaining the het-6 allele found in the normal-sequence LGII position; 16 were het-6(OR), retaining the allele in the translocated position. Restriction fragment length polymorphisms in 45 escape strains were examined with probes made from cosmids that spanned the translocated region. Along with electrophoretic analysis of chromosomes from three escape strains, RFLPs showed that escape is associated with deletion of part of one or the other of the duplicated DNA segments. Deletions ranged in size from ~70 kbp up to putatively the entire 270-kbp translocated region but always included a 35-kbp region wherein we hypothesize het-6 is located. The deletion spectrum at het-6 thus resembles other cases where mitotic deletions occur such as of tumor suppressor genes and of the hprt gene (coding for hypoxanthine-guanine phosphoribosyl-transferase) in humans. PMID:8889517

  3. [Manic episode in a patient with Beçhet's disease].

    PubMed

    Bozikas, V; Ramnalis, A; Dittopoulos, J; Iakovou, J; Garyfallos, G; Fokas, K

    2015-01-01

    Beçhet's disease (BD) is a chronic, heterogeneous, multisystem disease that affects young males and females around the Mediterranean region, as well as from Far and Middle East. Its etiology is vague with vasculitis being its main pathological feature. International diagnostic criteria have been established and they require the presence of recurrent oral ulcerations plus two of the following: Recurrent genital ulceration, eye lesions, skin lesions and positive pathergy test. A significant number of patients with Beçhet's disease suffers from symptoms from the central nervous system (CNS), while the most common clinical symptoms are pyramidal signs, mental-behavioral changes, hemiparesis and brain stem syndrome. The existence of mental-behavioral changes seems to be one of the most common findings in patients with Neuro-Beçhet (N-BD). These changes seem to be related with memory and attention deficits, and the process of deterioration continues even in attack-free periods, suggesting a continuously active disease process in the CNS. The prevalence of anxiety, depression and general psychiatric symptoms is higher among patients with BD compared to healthy individuals. However, the association between psychiatric symptoms and BD is not clearly understood. On the other hand, syndromes like psychosis or bipolar disorder appear to be less frequent, especially in attack-free periods. We describe the case of a 52-year old woman with Beçhet's disease who developed a single manic episode 13 years after the onset of Beçhet's disease. A 52-year old woman, suffering from Beçhet's disease since the age of 39, developed manic symptoms, namely elevated mood, pressured speech, flight of ideas, distractibility and decreased need for sleep. The above symptoms developed during a period that no other symptoms of Beçhet's disease were present. Moreover there was no other manifestation from the nervous system. A brain MRI was unremarkable, while a brain SPECT study revealed severe

  4. Structural insights into HetR−PatS interaction involved in cyanobacterial pattern formation

    PubMed Central

    Hu, Hai-Xi; Jiang, Yong-Liang; Zhao, Meng-Xi; Cai, Kun; Liu, Sanling; Wen, Bin; Lv, Pei; Zhang, Yonghui; Peng, Junhui; Zhong, Hui; Yu, Hong-Mei; Ren, Yan-Min; Zhang, Zhiyong; Tian, Changlin; Wu, Qingfa; Oliveberg, Mikael; Zhang, Cheng-Cai; Chen, Yuxing; Zhou, Cong-Zhao

    2015-01-01

    The one-dimensional pattern of heterocyst in the model cyanobacterium Anabaena sp. PCC 7120 is coordinated by the transcription factor HetR and PatS peptide. Here we report the complex structures of HetR binding to DNA, and its hood domain (HetRHood) binding to a PatS-derived hexapeptide (PatS6) at 2.80 and 2.10 Å, respectively. The intertwined HetR dimer possesses a couple of novel HTH motifs, each of which consists of two canonical α-helices in the DNA-binding domain and an auxiliary α-helix from the flap domain of the neighboring subunit. Two PatS6 peptides bind to the lateral clefts of HetRHood, and trigger significant conformational changes of the flap domain, resulting in dissociation of the auxiliary α-helix and eventually release of HetR from the DNA major grove. These findings provide the structural insights into a prokaryotic example of Turing model. PMID:26576507

  5. Gyroscopic Instruments for Instrument Flying

    NASA Technical Reports Server (NTRS)

    Brombacher, W G; Trent, W C

    1938-01-01

    The gyroscopic instruments commonly used in instrument flying in the United States are the turn indicator, the directional gyro, the gyromagnetic compass, the gyroscopic horizon, and the automatic pilot. These instruments are described. Performance data and the method of testing in the laboratory are given for the turn indicator, the directional gyro, and the gyroscopic horizon. Apparatus for driving the instruments is discussed.

  6. Analyzing the birth and propagation of two distinct prions, [PSI+] and [Het-s](y), in yeast.

    PubMed

    Mathur, Vidhu; Taneja, Vibha; Sun, Yidi; Liebman, Susan W

    2010-05-01

    Various proteins, like the infectious yeast prions and the noninfectious human Huntingtin protein (with expanded polyQ), depend on a Gln or Asn (QN)-rich region for amyloid formation. Other prions, e.g., mammalian PrP and the [Het-s] prion of Podospora anserina, although still able to form infectious amyloid aggregates, do not have QN-rich regions. Furthermore, [Het-s] and yeast prions appear to differ dramatically in their amyloid conformation. Despite these differences, a fusion of the Het-s prion domain to GFP (Het-sPrD-GFP) can propagate in yeast as a prion called [Het-s](y). We analyzed the properties of two divergent prions in yeast: [Het-s](y) and the native yeast prion [PSI(+)] (prion form of translational termination factor Sup35). Curiously, the induced appearance and transmission of [PSI(+)] and [Het-s](y) aggregates is remarkably similar. Overexpression of tagged prion protein (Sup35-GFP or Het-sPrD-GFP) in nonprion cells gives rise to peripheral, and later internal, ring/mesh-like aggregates. The cells with these ring-like aggregates give rise to daughters with one (perivacuolar) or two (perivacuolar and juxtanuclear) dot-like aggregates per cell. These line, ring, mesh, and dot aggregates are not really the transmissible prion species and should only be regarded as phenotypic markers of the presence of the prions. Both [PSI(+)] and [Het-s](y) first appear in daughters as numerous tiny dot-like aggregates, and both require the endocytic protein, Sla2, for ring formation, but not propagation. PMID:20219972

  7. Relationships between the ABC-Exporter HetC and Peptides that Regulate the Spatiotemporal Pattern of Heterocyst Distribution in Anabaena

    PubMed Central

    Corrales-Guerrero, Laura; Flores, Enrique; Herrero, Antonia

    2014-01-01

    In the model cyanobacterium Anabaena sp. PCC 7120, cells called heterocysts that are specialized in the fixation of atmospheric nitrogen differentiate from vegetative cells of the filament in the absence of combined nitrogen. Heterocysts follow a specific distribution pattern along the filament, and a number of regulators have been identified that influence the heterocyst pattern. PatS and HetN, expressed in the differentiating cells, inhibit the differentiation of neighboring cells. At least PatS appears to be processed and transferred from cell to cell. HetC is similar to ABC exporters and is required for differentiation. We present an epistasis analysis of these regulatory genes and of genes, hetP and asr2819, successively downstream from hetC, and we have studied the localization of HetC and HetP by use of GFP fusions. Inactivation of patS, but not of hetN, allowed differentiation to proceed in a hetC background, whereas inactivation of hetC in patS or patS hetN backgrounds decreased the frequency of contiguous proheterocysts. A HetC-GFP protein is localized to the heterocysts and especially near their cell poles, and a putative HetC peptidase domain was required for heterocyst differentiation but not for HetC-GFP localization. hetP is also required for heterocyst differentiation. A HetP-GFP protein localized mostly near the heterocyst poles. ORF asr2819, which we denote patC, encodes an 84-residue peptide and is induced upon nitrogen step-down. Inactivation of patC led to a late spreading of the heterocyst pattern. Whereas HetC and HetP appear to have linked functions that allow heterocyst differentiation to progress, PatC may have a role in selecting sites of differentiation, suggesting that these closely positioned genes may be functionally related. PMID:25121608

  8. Relationships between the ABC-exporter HetC and peptides that regulate the spatiotemporal pattern of heterocyst distribution in Anabaena.

    PubMed

    Corrales-Guerrero, Laura; Flores, Enrique; Herrero, Antonia

    2014-01-01

    In the model cyanobacterium Anabaena sp. PCC 7120, cells called heterocysts that are specialized in the fixation of atmospheric nitrogen differentiate from vegetative cells of the filament in the absence of combined nitrogen. Heterocysts follow a specific distribution pattern along the filament, and a number of regulators have been identified that influence the heterocyst pattern. PatS and HetN, expressed in the differentiating cells, inhibit the differentiation of neighboring cells. At least PatS appears to be processed and transferred from cell to cell. HetC is similar to ABC exporters and is required for differentiation. We present an epistasis analysis of these regulatory genes and of genes, hetP and asr2819, successively downstream from hetC, and we have studied the localization of HetC and HetP by use of GFP fusions. Inactivation of patS, but not of hetN, allowed differentiation to proceed in a hetC background, whereas inactivation of hetC in patS or patS hetN backgrounds decreased the frequency of contiguous proheterocysts. A HetC-GFP protein is localized to the heterocysts and especially near their cell poles, and a putative HetC peptidase domain was required for heterocyst differentiation but not for HetC-GFP localization. hetP is also required for heterocyst differentiation. A HetP-GFP protein localized mostly near the heterocyst poles. ORF asr2819, which we denote patC, encodes an 84-residue peptide and is induced upon nitrogen step-down. Inactivation of patC led to a late spreading of the heterocyst pattern. Whereas HetC and HetP appear to have linked functions that allow heterocyst differentiation to progress, PatC may have a role in selecting sites of differentiation, suggesting that these closely positioned genes may be functionally related. PMID:25121608

  9. Spatial fluctuations in expression of the heterocyst differentiation regulatory gene hetR in Anabaena filaments.

    PubMed

    Corrales-Guerrero, Laura; Tal, Asaf; Arbel-Goren, Rinat; Mariscal, Vicente; Flores, Enrique; Herrero, Antonia; Stavans, Joel

    2015-04-01

    Under nitrogen deprivation, filaments of the cyanobacterium Anabaena undergo a process of development, resulting in a one-dimensional pattern of nitrogen-fixing heterocysts separated by about ten photosynthetic vegetative cells. Many aspects of gene expression before nitrogen deprivation and during the developmental process remain to be elucidated. Furthermore, the coupling of gene expression fluctuations between cells along a multicellular filament is unknown. We studied the statistics of fluctuations of gene expression of HetR, a transcription factor essential for heterocyst differentiation, both under steady-state growth in nitrogen-rich conditions and at different times following nitrogen deprivation, using a chromosomally-encoded translational hetR-gfp fusion. Statistical analysis of fluorescence at the individual cell level in wild-type and mutant filaments demonstrates that expression fluctuations of hetR in nearby cells are coupled, with a characteristic spatial range of circa two to three cells, setting the scale for cellular interactions along a filament. Correlations between cells predominantly arise from intercellular molecular transfer and less from cell division. Fluctuations after nitrogen step-down can build up on those under nitrogen-replete conditions. We found that under nitrogen-rich conditions, basal, steady-state expression of the HetR inhibitor PatS, cell-cell communication influenced by the septal protein SepJ and positive HetR auto-regulation are essential determinants of fluctuations in hetR expression and its distribution along filaments. A comparison between the expression of hetR-gfp under nitrogen-rich and nitrogen-poor conditions highlights the differences between the two HetR inhibitors PatS and HetN, as well as the differences in specificity between the septal proteins SepJ and FraC/FraD. Activation, inhibition and cell-cell communication lie at the heart of developmental processes. Our results show that proteins involved in these

  10. Spatial Fluctuations in Expression of the Heterocyst Differentiation Regulatory Gene hetR in Anabaena Filaments

    PubMed Central

    Corrales-Guerrero, Laura; Tal, Asaf; Arbel-Goren, Rinat; Mariscal, Vicente; Flores, Enrique; Herrero, Antonia; Stavans, Joel

    2015-01-01

    Under nitrogen deprivation, filaments of the cyanobacterium Anabaena undergo a process of development, resulting in a one-dimensional pattern of nitrogen-fixing heterocysts separated by about ten photosynthetic vegetative cells. Many aspects of gene expression before nitrogen deprivation and during the developmental process remain to be elucidated. Furthermore, the coupling of gene expression fluctuations between cells along a multicellular filament is unknown. We studied the statistics of fluctuations of gene expression of HetR, a transcription factor essential for heterocyst differentiation, both under steady-state growth in nitrogen-rich conditions and at different times following nitrogen deprivation, using a chromosomally-encoded translational hetR-gfp fusion. Statistical analysis of fluorescence at the individual cell level in wild-type and mutant filaments demonstrates that expression fluctuations of hetR in nearby cells are coupled, with a characteristic spatial range of circa two to three cells, setting the scale for cellular interactions along a filament. Correlations between cells predominantly arise from intercellular molecular transfer and less from cell division. Fluctuations after nitrogen step-down can build up on those under nitrogen-replete conditions. We found that under nitrogen-rich conditions, basal, steady-state expression of the HetR inhibitor PatS, cell-cell communication influenced by the septal protein SepJ and positive HetR auto-regulation are essential determinants of fluctuations in hetR expression and its distribution along filaments. A comparison between the expression of hetR-gfp under nitrogen-rich and nitrogen-poor conditions highlights the differences between the two HetR inhibitors PatS and HetN, as well as the differences in specificity between the septal proteins SepJ and FraC/FraD. Activation, inhibition and cell-cell communication lie at the heart of developmental processes. Our results show that proteins involved in these

  11. Monitoring Instruments

    ERIC Educational Resources Information Center

    Environmental Science and Technology (Environmental Control Issue), 1977

    1977-01-01

    This section contains a listing of the manufacturers of environmental monitoring instruments. The manufacturers are listed alphabetically under product headings. Addresses are included in a different section. (MA)

  12. Cordless Instruments

    NASA Astrophysics Data System (ADS)

    1981-01-01

    Black & Decker's new cordless lightweight battery powered precision instruments, adapted from NASA's Apollo Lunar Landing program, have been designed to give surgeons optimum freedom and versatility in the operating room. Orthopedic instrument line includes a drill, a driver/reamer and a sagittal saw. All provide up to 20 minutes on a single charge. Power pack is the instrument's handle which is removable for recharging. Microprocessor controlled recharging unit can recharge two power packs together in 30 minutes. Instruments can be gas sterilized, steam-sterilized in an autoclave or immersed for easy cleaning.

  13. SURVEY INSTRUMENT

    DOEpatents

    Borkowski, C J

    1954-01-19

    This pulse-type survey instrument is suitable for readily detecting {alpha} particles in the presence of high {beta} and {gamma} backgrounds. The instruments may also be used to survey for neutrons, {beta} particles and {gamma} rays by employing suitably designed interchangeable probes and selecting an operating potential to correspond to the particular probe.

  14. Measuring space radiation with ADIS instruments

    NASA Astrophysics Data System (ADS)

    Connell, J. J.; Lopate, C.; McKibben, R. B.; Merk, J.

    2010-09-01

    Measurements of radiation in space, cosmic rays and Solar energetic particles, date back to the dawn of space flight. Solid state detectors, the basis of most modern high energy charged particle instruments, first flew in space in the 1960's. Modern particle spectrometers, such as ACE/CRIS, ACE/SIS and Ulysses/HET, can measure the elemental and isotopic composition of ions through the iron peak. This is achieved by using position sensing detectors (PSD's) arranged into hodoscopes to measure particle trajectories through the instrument, allowing for pathlength corrections to energy loss measurements. The Angle Detecting Inclined Sensor (ADIS) technique measures particle angle of incidence using a simple system of detectors inclined to the instrument axis. It achieves elemental resolution well beyond iron, and isotopic resolution for moderate mass elements without the complexity of position sensing detectors. An ADIS instrument was selected to fly as the High Energy Particle Sensor (HEPS) on NPOESS, but was de-scoped with the rest of the space weather suite. Another ADIS instrument, the Energetic Heavy Ion Sensor (EHIS), is being developed for GOES-R. UNH has built and tested a engineering unit of the EHIS. Applications for manned dosimetery on the Crew Exploration Vehicle (CEV) are also being explored. The basic ADIS technique is explained and accelerator data for heavy ions shown.

  15. Inactivation of the Podospora anserina vegetative incompatibility locus het-c, whose product resembles a glycolipid transfer protein, drastically impairs ascospore production.

    PubMed Central

    Saupe, S; Descamps, C; Turcq, B; Bégueret, J

    1994-01-01

    The het-c locus contains different alleles that elicit nonallelic vegetative incompatibility through specific interactions with alleles of the unlinked loci het-e and het-d. The het-c2 allele has been cloned. It encodes a 208-amino acid polypeptide that is similar to a glycolipid transfer protein purified from pig brain. Disruption of this gene drastically impairs ascospore production in homozygous crosses, and some mutants exhibit abnormal branching of apical hyphae. The protein encoded by het-c2 is essential in the biology of the fungus and may be involved in cell-wall biosynthesis. Images PMID:8016091

  16. Instrumentation '79.

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1979

    1979-01-01

    Surveys the state of commerical development of analytical instrumentation as reflected by the Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy. Includes optical spectroscopy, liquid chromatography, magnetic spectrometers, and x-ray. (Author/MA)

  17. Astronomical instruments.

    NASA Astrophysics Data System (ADS)

    Rai, R. N.

    Indian astronomers have devised a number of instruments and the most important of these is the armillary sphere. The earliest armillary spheres were very simple instruments. Ptolemy in his Almagest enumerates at least three. The simplest of all was the equinoctial armilla. They had also the solstitial armilla which was a double ring, erected in the plane of the meridian with a rotating inner circle. This was used to measure the solar altitude.

  18. Oceanographic Instrument

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Developed under NASA contract, the Fast Repetition Rate (FRR) fluorometer is a computer-controlled instrument for measuring the fluorescence of phytoplankton, microscopic plant forms that provide sustenance for animal life in the oceans. The fluorometer sensor is towed by ship through the water and the resulting printouts are compared with satellite data. The instrument is non-destructive and can be used in situ, providing scientific information on ocean activity and productivity.

  19. Characterization of flow in the HET enclosure following ventilation and application of low-emissive coatings

    NASA Astrophysics Data System (ADS)

    Good, John M.

    2004-10-01

    In 2002 the method of thermal control within the HET enclosure was dramatically changed by the installation of 300 square meters of ventilated area to the stationary walls below the rotating dome. During the month of July 2003 a nightly study of the airflow was undertaken at the HET. While dome seeing has shown substantial improvement, this study revealed a number of counter intuitive flow modes which indicate that additional seeing improvements can be achieved by selective ventilation of the HET dome above the ring-wall. Additional study of dome seeing revealed substantial sub-cooling of the dome skin. Measurements of the skin temperature of the un-insulated dome revealed night-time cooling of local ambient air by as much as 3.6° C. An investigation of coating alternatives resulted in the application of aluminum foil tape, which reduced the temperature drop to 0.3° C. Presently, the performance of the HET (as low as EE50=0.8 arc-seconds) is not thought to be limited by dome seeing.

  20. The heterocyst differentiation transcriptional regulator HetR of the filamentous cyanobacterium Anabaena forms tetramers and can be regulated by phosphorylation.

    PubMed

    Valladares, Ana; Flores, Enrique; Herrero, Antonia

    2016-02-01

    Many filamentous cyanobacteria respond to the external cue of nitrogen scarcity by the differentiation of heterocysts, cells specialized in the fixation of atmospheric nitrogen in oxic environments. Heterocysts follow a spatial pattern along the filament of two heterocysts separated by ca. 10-15 vegetative cells performing oxygenic photosynthesis. HetR is a transcriptional regulator that directs heterocyst differentiation. In the model strain Anabaena sp. PCC 7120, the HetR protein was observed in various oligomeric forms in vivo, including a tetramer that peaked with maximal hetR expression during differentiation. Tetramers were not detected in a hetR point mutant incapable of differentiation, but were conspicuous in an over-differentiating strain lacking the PatS inhibitor. In differentiated filaments the HetR tetramer was restricted to heterocysts, being undetectable in vegetative cells. HetR co-purified with RNA polymerase from Anabaena mainly as a tetramer. In vitro, purified recombinant HetR was distributed between monomers, dimers, trimers and tetramers, and it was phosphorylated when incubated with (γ-(32)P)ATP. Phosphorylation and PatS hampered the accumulation of HetR tetramers and impaired HetR binding to DNA. In summary, tetrameric HetR appears to represent a functionally relevant form of HetR, whose abundance in the Anabaena filament could be negatively regulated by phosphorylation and by PatS. PMID:26552991

  1. Instrumented SSH

    SciTech Connect

    Campbell, Scott; Campbell, Scott

    2009-05-27

    NERSC recently undertook a project to access and analyze Secure Shell (SSH) related data. This includes authentication data such as user names and key fingerprints, interactive session data such as keystrokes and responses, and information about noninteractive sessions such as commands executed and files transferred. Historically, this data has been inaccessible with traditional network monitoring techniques, but with a modification to the SSH daemon, this data can be passed directly to intrusion detection systems for analysis. The instrumented version of SSH is now running on all NERSC production systems. This paper describes the project, details about how SSH was instrumented, and the initial results of putting this in production.

  2. Research Instruments

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The GENETI-SCANNER, newest product of Perceptive Scientific Instruments, Inc. (PSI), rapidly scans slides, locates, digitizes, measures and classifies specific objects and events in research and diagnostic applications. Founded by former NASA employees, PSI's primary product line is based on NASA image processing technology. The instruments karyotype - a process employed in analysis and classification of chromosomes - using a video camera mounted on a microscope. Images are digitized, enabling chromosome image enhancement. The system enables karyotyping to be done significantly faster, increasing productivity and lowering costs. Product is no longer being manufactured.

  3. Geoscience instrumentation

    NASA Technical Reports Server (NTRS)

    Wolff, E. A. (Editor); Mercanti, E. P.

    1974-01-01

    Geoscience instrumentation systems are considered along with questions of geoscience environment, signal processing, data processing, and design problems. Instrument platforms are examined, taking into account ground platforms, airborne platforms, ocean platforms, and space platforms. In situ and laboratory sensors described include acoustic wave sensors, age sensors, atmospheric constituent sensors, biological sensors, cloud particle sensors, electric field sensors, electromagnetic field sensors, precision geodetic sensors, gravity sensors, ground constituent sensors, horizon sensors, humidity sensors, ion and electron sensors, magnetic field sensors, tide sensors, and wind sensors. Remote sensors are discussed, giving attention to sensing techniques, acoustic echo-sounders, gamma ray sensors, optical sensors, radar sensors, and microwave radiometric sensors.

  4. Weather Instruments.

    ERIC Educational Resources Information Center

    Brantley, L. Reed, Sr.; Demanche, Edna L.; Klemm, E. Barbara; Kyselka, Will; Phillips, Edwin A.; Pottenger, Francis M.; Yamamoto, Karen N.; Young, Donald B.

    This booklet presents some activities to measure various weather phenomena. Directions for constructing a weather station are included. Instruments including rain gauges, thermometers, wind vanes, wind speed devices, humidity devices, barometers, atmospheric observations, a dustfall jar, sticky-tape can, detection of gases in the air, and pH of…

  5. RHIC instrumentation

    SciTech Connect

    Shea, T. J.; Witkover, R. L.

    1998-12-10

    The Relativistic Heavy Ion Collider (RHIC) consists of two 3.8 km circumference rings utilizing 396 superconducting dipoles and 492 superconducting quadrupoles. Each ring will accelerate approximately 60 bunches of 10{sup 11} protons to 250 GeV, or 10{sup 9} fully stripped gold ions to 100 GeV/nucleon. Commissioning is scheduled for early 1999 with detectors for some of the 6 intersection regions scheduled for initial operation later in the year. The injection line instrumentation includes: 52 beam position monitor (BPM) channels, 56 beam loss monitor (BLM) channels, 5 fast integrating current transformers and 12 video beam profile monitors. The collider ring instrumentation includes: 667 BPM channels, 400 BLM channels, wall current monitors, DC current transformers, ionization profile monitors (IPMs), transverse feedback systems, and resonant Schottky monitors. The use of superconducting magnets affected the beam instrumentation design. The BPM electrodes must function in a cryogenic environment and the BLM system must prevent magnet quenches from either fast or slow losses with widely different rates. RHIC is the first superconducting accelerator to cross transition, requiring close monitoring of beam parameters at this time. High space-charge due to the fully stripped gold ions required the IPM to collect magnetically guided electrons rather than the conventional ions. Since polarized beams will also be accelerated in RHIC, additional constraints were put on the instrumentation. The orbit must be well controlled to minimize depolarizing resonance strengths. Also, the position monitors must accommodate large orbit displacements within the Siberian snakes and spin rotators. The design of the instrumentation will be presented along with results obtained during bench tests, the injection line commissioning, and the first sextant test.

  6. RHIC instrumentation

    NASA Astrophysics Data System (ADS)

    Shea, T. J.; Witkover, R. L.

    1998-12-01

    The Relativistic Heavy Ion Collider (RHIC) consists of two 3.8 km circumference rings utilizing 396 superconducting dipoles and 492 superconducting quadrupoles. Each ring will accelerate approximately 60 bunches of 1011 protons to 250 GeV, or 109 fully stripped gold ions to 100 GeV/nucleon. Commissioning is scheduled for early 1999 with detectors for some of the 6 intersection regions scheduled for initial operation later in the year. The injection line instrumentation includes: 52 beam position monitor (BPM) channels, 56 beam loss monitor (BLM) channels, 5 fast integrating current transformers and 12 video beam profile monitors. The collider ring instrumentation includes: 667 BPM channels, 400 BLM channels, wall current monitors, DC current transformers, ionization profile monitors (IPMs), transverse feedback systems, and resonant Schottky monitors. The use of superconducting magnets affected the beam instrumentation design. The BPM electrodes must function in a cryogenic environment and the BLM system must prevent magnet quenches from either fast or slow losses with widely different rates. RHIC is the first superconducting accelerator to cross transition, requiring close monitoring of beam parameters at this time. High space-charge due to the fully stripped gold ions required the IPM to collect magnetically guided electrons rather than the conventional ions. Since polarized beams will also be accelerated in RHIC, additional constraints were put on the instrumentation. The orbit must be well controlled to minimize depolarizing resonance strengths. Also, the position monitors must accommodate large orbit displacements within the Siberian snakes and spin rotators. The design of the instrumentation will be presented along with results obtained during bench tests, the injection line commissioning, and the first sextant test.

  7. RHIC instrumentation

    SciTech Connect

    Shea, T.J.; Witkover, R.L.

    1998-12-01

    The Relativistic Heavy Ion Collider (RHIC) consists of two 3.8 km circumference rings utilizing 396 superconducting dipoles and 492 superconducting quadrupoles. Each ring will accelerate approximately 60 bunches of 10{sup 11} protons to 250 GeV, or 10{sup 9} fully stripped gold ions to 100 GeV/nucleon. Commissioning is scheduled for early 1999 with detectors for some of the 6 intersection regions scheduled for initial operation later in the year. The injection line instrumentation includes: 52 beam position monitor (BPM) channels, 56 beam loss monitor (BLM) channels, 5 fast integrating current transformers and 12 video beam profile monitors. The collider ring instrumentation includes: 667 BPM channels, 400 BLM channels, wall current monitors, DC current transformers, ionization profile monitors (IPMs), transverse feedback systems, and resonant Schottky monitors. The use of superconducting magnets affected the beam instrumentation design. The BPM electrodes must function in a cryogenic environment and the BLM system must prevent magnet quenches from either fast or slow losses with widely different rates. RHIC is the first superconducting accelerator to cross transition, requiring close monitoring of beam parameters at this time. High space-charge due to the fully stripped gold ions required the IPM to collect magnetically guided electrons rather than the conventional ions. Since polarized beams will also be accelerated in RHIC, additional constraints were put on the instrumentation. The orbit must be well controlled to minimize depolarizing resonance strengths. Also, the position monitors must accommodate large orbit displacements within the Siberian snakes and spin rotators. The design of the instrumentation will be presented along with results obtained during bench tests, the injection line commissioning, and the first sextant test. {copyright} {ital 1998 American Institute of Physics.}

  8. VIRUS: a massively replicated integral-field spectrograph for HET

    NASA Astrophysics Data System (ADS)

    Hill, Gary J.; MacQueen, Phillip J.; Tufts, Joseph R.; Kelz, Andreas; Roth, Martin M.; Altmann, Werner; Segura, Pedro; Gebhardt, Karl; Palunas, Povilas

    2006-06-01

    We present the design of, and the science drivers for, the Visible Integral-field Replicable Unit Spectrograph (VIRUS). This instrument is made up of 145 individually small and simple spectrographs, each fed by a fiber integral field unit. The total VIRUS-145 instrument covers ~30 sq. arcminutes per observation, providing integral field spectroscopy from 340 to 570 nm, simultaneously, of 35,670 spatial elements, each 1 sq. arcsecond on the sky. This corresponds to 15 million resolution elements per exposure. VIRUS-145 will be mounted on the Hobby-Eberly Telescope and fed by a new wide-field corrector with 22 arcminutes diameter field of view. VIRUS represents a new approach to spectrograph design, offering the science multiplex advantage of huge sky coverage for an integral field spectrograph, coupled with the engineering multiplex advantage of >100 spectrographs making up a whole. VIRUS is designed for the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX) which will use baryonic acoustic oscillations imprinted on the large-scale distribution of Lyman-α emitting galaxies to provide unique constraints on the expansion history of the universe that can constrain the properties of dark energy.

  9. OMEGACAM and Gravitational Lensing

    NASA Astrophysics Data System (ADS)

    Christen, Fabrice Frédéric Thiébaut

    2007-04-01

    Het proefschrift van Fabrice Christen gaat over de ontwikkeling van nieuwe methoden voor het corrigeren van (digitale) foto's van melkwegstelsels. Met deze methoden kunnen de beelden uit het heelal beter worden geanalyseerd. Het eerste gedeelte is gewijd aan het werk dat bij ESO is uitgevoerd aan de CCD's van de OmegaCAM camera, het enige instrument van de VST. OmegaCAM is een optische groothoekcamera met een beeldveld van een vierkante graad, opgebouwd uit een mozaiek van 8 bij 4 CCD's. Van elk onderdeel moeten alle kenmerken volledig bekend zijn voordat het in het CCD mozaiek geplaatst kan worden. In het tweede deel van dit proefschrift wordt de ontwikkeling van een nieuwe methode voor het corrigeren van de ``point-spread function'' (PSF) en schatten van de ellipticiteit van de melkwegstelsels besproken. De nieuwe techniek wordt getest en vergeleken met een door sterrenkundigen algemeen gebruikte methode in het veld van zwaartekrachtslenzen, de Kaiser, Squire en Broadhurst (KSB) methode. De nieuwe methode, gebaseerd op shapelet ontleding (vergelijkbaar met wavelet ontleding), gaat verder, en is sneller en theoretisch preciezer dan de KSB methode. Door gebruik te maken van de gecorrigeerde ellipticiteit, kunnen we een statistische analyse uitvoeren om er een kosmisch vervormingssignaal uit te halen. De licht vervormde beelden van de melkwegstelsels bewij zen dat de niet-homogene massaverdeling op megaparsec-schaal voornamelijk bestaat uit grote hoeveelheden donkere materie. Verder vergelijken we de schattingen van de ellipticiteit van de shapelet en KSB methode. Bovendien voeren we ook nog een melkwegstelsel-melkwegstelsel lens analyse uit op de 50 VLT Fors1 afbeeldingen en slagen we erin de belangrijkste eigenschappen van de halo's van de stelsels, die zich op een afstand van een- tot tweeduizend megaparsec (1 parsec = 3,26 lichtjaar = 3,085 x 10^16 meter) bevinden, te bepalen door gebruik te maken van twee modellen van melkwegstelselhalo's. Vergeleken met andere

  10. Optical Instruments

    NASA Astrophysics Data System (ADS)

    1990-01-01

    Precision Lapping and Optical Co. has developed a wide variety of hollow retroreflector systems for applications involving the entire optical spectrum; they are, according to company literature, cheaper, more accurate, lighter and capable of greater size than solid prisms. Precision Lapping's major customers are aerospace and defense companies, government organizations, R&D and commercial instrument companies. For example, Precision Lapping supplies hollow retroreflectors for the laser fire control system of the Army's Abrams tank, and retroreflectors have been and are being used in a number of space tests relative to the Air Force's Strategic Defense Initiative research program. An example of a customer/user is Chesapeake Laser Systems, producer of the Laser Tracker System CMS-2000, which has applications in SDI research and industrial robotics. Another customer is MDA Scientific, Inc., manufacturer of a line of toxic gas detection systems used to monitor hazardous gases present in oil fields, refineries, offshore platforms, chemical plants, waste storage sites and other locations where gases are released into the environment.

  11. The Homologue of het-c of Neurospora crassa Lacks Vegetative Compatibility Function in Fusarium proliferatum†

    PubMed Central

    Kerényi, Zoltán; Oláh, Brigitta; Jeney, Apor; Hornok, László; Leslie, John F.

    2006-01-01

    For two fungal strains to be vegetatively compatible and capable of forming a stable vegetative heterokaryon they must carry matching alleles at a series of loci variously termed het or vic genes. Cloned het/vic genes from Neurospora crassa and Podospora anserina have no obvious functional similarity and have various cellular functions. Our objective was to identify the homologue of the Neurospora het-c gene in Fusarium proliferatum and to determine if this gene has a vegetative compatibility function in this economically important and widely dispersed fungal pathogen. In F. proliferatum and five other closely related Fusarium species we found a few differences in the DNA sequence, but the changes were silent and did not alter the amino acid sequence of the resulting protein. Deleting the gene altered sexual fertility as the female parent, but it did not alter male fertility or existing vegetative compatibility interactions. Replacement of the allele-specific portion of the coding sequence with the sequence of an alternate allele in N. crassa did not result in a vegetative incompatibility response in transformed strains of F. proliferatum. Thus, the fphch gene in Fusarium appears unlikely to have the vegetative compatibility function associated with its homologue in N. crassa. These results suggest that the vegetative compatibility phenotype may result from convergent evolution. Thus, the genes involved in this process may need to be identified at the species level or at the level of a group of species and could prove to be attractive targets for the development of antifungal agents. PMID:17021201

  12. Different functions of HetR, a master regulator of heterocyst differentiation in Anabaena sp. PCC 7120, can be separated by mutation

    PubMed Central

    Khudyakov, Ivan Y.; Golden, James W.

    2004-01-01

    The HetR protein has long been recognized as a key player in the regulation of heterocyst development. HetR is known to possess autoproteolytic and DNA-binding activities. During a search for mutants of Anabaena sp. PCC 7120 that can overcome heterocyst suppression caused by overexpression of the patS gene, which encodes a negative regulator of differentiation, a bypass mutant strain, S2-45, was isolated that produced a defective pattern (Pat phenotype) of irregularly spaced single and multiple contiguous heterocysts (Mch phenotype) in combined nitrogen-free medium. Analysis of the S2-45 mutant revealed a R223W mutation in HetR, and reconstruction in the wild-type background showed that this mutation was responsible for the Mch phenotype and resistance not only to overexpressed patS, but also to overexpressed hetN, another negative regulator of differentiation. Ectopic overexpression of the hetRR223W allele in the hetRR223W background resulted in a conditionally lethal (complete differentiation) phenotype. Analysis of the heterocyst pattern in the hetRR223W mutant revealed that heterocysts differentiate essentially randomly along filaments, indicating that this mutation results in an active protein that is insensitive to the major signals governing heterocyst pattern formation. These data provide genetic evidence that, apart from being an essential activator of differentiation, HetR plays a central role in the signaling pathway that controls the heterocyst pattern. PMID:15520378

  13. Delta excitations in heavy nuclei induced by (3He,t) and (p,n) reactions

    NASA Astrophysics Data System (ADS)

    Esbensen, H.; Lee, T.-S. H.

    1985-12-01

    Delta excitations in heavy nuclei, induced by charge exchange reactions, are studied using the surface response model. The residual pion-exchange interaction and the self-energy of the delta in a nuclear medium is included in the random-phase-approximation response. The peak position observed in (3He,t) reactions can be explained by the self-energy of the delta extracted from pion-nucleus scattering, and the magnitude of the cross section is consistent with Glauber theory. The comparison to (p,n) data is reasonable; contributions from neutron decay of the delta, which are left out in the calculations, constitute a substantial experimental background.

  14. Radiological instrument

    SciTech Connect

    Kronenberg, S.; McLaughlin, W.L.; Seibentritt, C.R. Jr.

    1986-12-23

    An instrument is described for measuring radiation, particularly nuclear radiation, comprising: a radiation sensitive structure pivoted toward one end and including a pair of elongated solid members contiguously joined together along their length dimensions and having a common planar interface therebetween. One of the pairs of members is comprised of radiochromic material whose index of refraction changes due to anomolous dispersion as a result of being exposed to nuclear radiation. The pair of members further has mutually different indices of refraction with the member having the larger index of refraction further being transparent for the passage of light and of energy therethrough; means located toward the other end of the structure for varying the angle of longitudinal elevation of the pair of members; means for generating and projecting a beam of light into one end of the member having the larger index of refraction. The beam of light is projected toward the planar interface where it is reflected out of the other end of the same member as a first output beam; means projecting a portion of the beam of light into one end of the member having the larger index of refraction where it traverses therethrough without reflection and out of the other end of the same member as a second output beam; and means adjacent the structure for receiving the first and second output beams, whereby a calibrated change in the angle of elevation of the structure between positions of equal intensity of the first and second output beams prior to and following exposure provides a measure of the radiation sensed due to a change of refraction of the radiochromic material.

  15. Spectroscopic Instruments

    NASA Astrophysics Data System (ADS)

    Kunze, Hans-Joachim

    The selection of a spectrographic system including the detector is governed by several aspects: - Wavelength region of interest - Low or high-resolution studies, survey spectra, line intensities only or detailed line profiles - Weak or strong emitter, which usually is equivalent to having a plasma of low or high density - Low or high time resolution, which basically determines the detector and only to a lesser degree the throughput of the system - Stigmatic or astigmatic image of the plasma in the exit plane Spectrometers with the exception of instruments for the X-ray region typically consist of: - An entrance slit (width w en, area A E) - A dispersive element - An optical system, which forms a spectrally dispersed image of the entrance slit in the exit plane - A detector in the exit plane Figure 3.1 illustrates a schematic layout. Dispersing elements are prisms, gratings, interferometers, and crystals. The imaging system consists usually of a lens L1 (or mirror M1) collimating the radiation from the entrance slit, and a lens L2 (or mirror M2) focusing the radiation in the exit (image) plane. Mirrors have the advantage of no chromatic aberration and can also be used at shorter wavelengths where glasses, quartz, and crystals absorb the radiation. Unfortunately, their reflectivity decreases at short wavelengths; this can be remedied to some degree by reducing the number of reflecting surfaces and employing spherical or even toroidal gratings which combine focusing and dispersing properties. The optical system (L1, L2) or (M1, M2) becomes unnecessary.

  16. Improving the RV Precision of HET/HRS - The Tale of Two Iodine Atlases

    NASA Astrophysics Data System (ADS)

    Wang, Sharon Xuesong, Sharon; Wright, J.; Zhao, M.

    2014-01-01

    The absorption spectrum of an Iodine cell provided by a Fourier Transform Spectrometer (FTS) is considered the 'ground' truth in precise radial velocity (RV) work. Modeling the observed Iodine lines with the FTS scan spectrum anchors the absolute wavelength solution and spectrograph response function when extracting RVs from the stellar spectrum. As we continue our efforts in improving the RV precision of the Hobby-Eberly Telescope (HET) High Resolution Spectrograph (HRS), we discovered that errors and uncertainties associated with the FTS scan may comprise the RV precision. We have two FTS scans for the HET/HRS cell from two different FTS machines - from KPNO and NIST. The two scans differ in terms of absolute wavelength solution, wavelength dispersion scale, line depth, and line depth ratio. These two FTS scans provide us with an unusual and valuable opportunity to diagnose the effect on RV precision brought in by the Iodine FTS scan uncertainties. Furthermore, to diagnose the KPNO FTS scan quality, we obtained a 400,000 echelle spectrum (at a comparable resolution with the FTS scan) of the McDonald 2.7m telescope Iodine cell using the Tull Spectrograph, and compared it against the FTS scan of this cell. There are clear differences between the two spectra, which reveals the difficulties in obtaining the 'ground truth' Iodine spectrum in the precise RV work.

  17. Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

    PubMed

    Lamming, Dudley W; Ye, Lan; Astle, Clinton M; Baur, Joseph A; Sabatini, David M; Harrison, David E

    2013-08-01

    Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR) signaling pathway, extends the life span of yeast, worms, flies, and mice. Interventions that promote longevity are often correlated with increased insulin sensitivity, and it therefore is surprising that chronic rapamycin treatment of mice, rats, and humans is associated with insulin resistance (J Am Soc Nephrol., 19, 2008, 1411; Diabetes, 00, 2010, 00; Science, 335, 2012, 1638). We examined the effect of dietary rapamycin treatment on glucose homeostasis and insulin resistance in the genetically heterogeneous HET3 mouse strain, a strain in which dietary rapamycin robustly extends mean and maximum life span. We find that rapamycin treatment leads to glucose intolerance in both young and old HET3 mice, but in contrast to the previously reported effect of injected rapamycin in C57BL/6 mice, HET3 mice treated with dietary rapamycin responded normally in an insulin tolerance test. To gauge the overall consequences of rapamycin treatment on average blood glucose levels, we measured HBA1c. Dietary rapamycin increased HBA1c over the first 3 weeks of treatment in young animals, but the effect was lost by 3 months, and no effect was detected in older animals. Our results demonstrate that the extended life span of HET3 mice on a rapamycin diet occurs in the absence of major changes in insulin sensitivity and highlight the importance of strain background and delivery method in testing effects of longevity interventions. PMID:23648089

  18. Harvesting the noncirculating pool of polymorphonuclear leukocytes in rats by hetastarch exchange transfusion (HET): yield and functional assessment

    SciTech Connect

    Williams, J.H. Jr.; Moser, K.M.; Ulich, T.; Cairo, M.S.

    1987-11-01

    Isolation of polymorphonuclear leukocytes (PMN) provides an opportunity to study PMN activity in vitro and to label PMN for study of in vivo kinetics. However, simple phlebotomy (SP) of a small animal frequently yields too few PMN for in vitro handling, while PMN harvested from an induced-peritonitis may not accurately reflect PMN in a less stimulated state. We report a novel method of harvesting PMN from the circulation of rats, using hetastarch exchange transfusion (HET), which is both time and animal sparing. HET harvested 8-fold more PMN than SP. In vitro cell function was examined with assays of adherence, chemotaxis, bacterial killing, and superoxide generation. No significant (p less than 0.05) difference was found between PMN obtained by HET and pooled-PMN obtained by SP. In vivo function was examined following labeling with indium 111-oxine. The kinetics pattern described suggested normal migratory activity when compared to previous reports. The data demonstrate that rats possess a relatively large, noncirculating pool of PMN which is readily accessible by HET.

  19. Low activated incore instrument

    DOEpatents

    Ekeroth, D.E.

    1994-04-19

    Instrumentation is described for nuclear reactor head-mounted incore instrumentation systems fabricated of low nuclear cross section materials (i.e., zirconium or titanium). The instrumentation emits less radiation than that fabricated of conventional materials. 9 figures.

  20. Evaluating musical instruments

    SciTech Connect

    Campbell, D. Murray

    2014-04-01

    Scientific measurements of sound generation and radiation by musical instruments are surprisingly hard to correlate with the subtle and complex judgments of instrumental quality made by expert musicians.

  1. High Efficiency Thermionics (HET-IV) and Converter Advancement (CAP) programs. Final reports

    SciTech Connect

    Geller, C.B.; Murray, C.S.; Riley, D.R.; Desplat, J.L.; Hansen, L.K.; Hatch, G.L.; McVey, J.B.; Rasor, N.S.

    1996-04-01

    This report contains the final report of the High Efficiency Thermionics (HET-IV) Program, Attachment A, performed at Rasor Associates, Inc. (RAI); and the final report of the Converter Advancement Program (CAP), performed at the Bettis Atomic Power Laboratory, Attachment B. The phenomenology of cesium-oxygen thermionic converters was elucidated in these programs, and the factors that had prevented the achievement of stable, enhanced cesium-oxygen converter performance for the previous thirty years were identified. Based on these discoveries, cesium-oxygen vapor sources were developed that achieved stable performance with factor-of-two improvements in power density and thermal efficiency, relative to conventional, cesium-only ignited mode thermionic converters. Key achievements of the HET-IV/CAP programs are as follows: a new technique for measuring minute traces of oxygen in cesium atmospheres; the determination of the proper range of oxygen partial pressures for optimum converter performance--10{sup {minus}7} to 10{sup {minus}9} torr; the discovery, and analysis of the cesium-oxygen liquid migration and compositional segregation phenomena; the successful use of capillary forces to contain the migration phenomenon; the use of differential heating to control compositional segregation, and induce vapor circulation; the development of mechanically and chemically stable, porous reservoir structures; the development of precise, in situ oxygen charging methods; stable improvements in emitter performance, up to effective emitter bare work functions of 5.4 eV; stable improvements in barrier index, to value below 1.8 Volts; the development of detailed microscopic models for cesium-oxygen reservoir dynamics and collector work function behavior; and the discovery of new relationships between electrode geometry and Schock Instability.

  2. IOT Overview: IR Instruments

    NASA Astrophysics Data System (ADS)

    Mason, E.

    In this instrument review chapter the calibration plans of ESO IR instruments are presented and briefly reviewed focusing, in particular, on the case of ISAAC, which has been the first IR instrument at VLT and whose calibration plan served as prototype for the coming instruments.

  3. Astronomical Instruments in India

    NASA Astrophysics Data System (ADS)

    Sarma, Sreeramula Rajeswara

    The earliest astronomical instruments used in India were the gnomon and the water clock. In the early seventh century, Brahmagupta described ten types of instruments, which were adopted by all subsequent writers with minor modifications. Contact with Islamic astronomy in the second millennium AD led to a radical change. Sanskrit texts began to lay emphasis on the importance of observational instruments. Exclusive texts on instruments were composed. Islamic instruments like the astrolabe were adopted and some new types of instruments were developed. Production and use of these traditional instruments continued, along with the cultivation of traditional astronomy, up to the end of the nineteenth century.

  4. Subcellular Localization and Clues for the Function of the HetN Factor Influencing Heterocyst Distribution in Anabaena sp. Strain PCC 7120

    PubMed Central

    Corrales-Guerrero, Laura; Mariscal, Vicente; Nürnberg, Dennis J.; Elhai, Jeff; Mullineaux, Conrad W.; Flores, Enrique

    2014-01-01

    In the filamentous cyanobacterium Anabaena sp. strain PCC 7120, heterocysts are formed in the absence of combined nitrogen, following a specific distribution pattern along the filament. The PatS and HetN factors contribute to the heterocyst pattern by inhibiting the formation of consecutive heterocysts. Thus, inactivation of any of these factors produces the multiple contiguous heterocyst (Mch) phenotype. Upon N stepdown, a HetN protein with its C terminus fused to a superfolder version of green fluorescent protein (sf-GFP) or to GFP-mut2 was observed, localized first throughout the whole area of differentiating cells and later specifically on the peripheries and in the polar regions of mature heterocysts, coinciding with the location of the thylakoids. Polar localization required an N-terminal stretch comprising residues 2 to 27 that may represent an unconventional signal peptide. Anabaena strains expressing a version of HetN lacking this fragment from a mutant gene placed at the native hetN locus exhibited a mild Mch phenotype. In agreement with previous results, deletion of an internal ERGSGR sequence, which is identical to the C-terminal sequence of PatS, also led to the Mch phenotype. The subcellular localization in heterocysts of fluorescence resulting from the fusion of GFP to the C terminus of HetN suggests that a full HetN protein is present in these cells. Furthermore, the full HetN protein is more conserved among cyanobacteria than the internal ERGSGR sequence. These observations suggest that HetN anchored to thylakoid membranes in heterocysts may serve a function besides that of generating a regulatory (ERGSGR) peptide. PMID:25049089

  5. Subcellular localization and clues for the function of the HetN factor influencing heterocyst distribution in Anabaena sp. strain PCC 7120.

    PubMed

    Corrales-Guerrero, Laura; Mariscal, Vicente; Nürnberg, Dennis J; Elhai, Jeff; Mullineaux, Conrad W; Flores, Enrique; Herrero, Antonia

    2014-10-01

    In the filamentous cyanobacterium Anabaena sp. strain PCC 7120, heterocysts are formed in the absence of combined nitrogen, following a specific distribution pattern along the filament. The PatS and HetN factors contribute to the heterocyst pattern by inhibiting the formation of consecutive heterocysts. Thus, inactivation of any of these factors produces the multiple contiguous heterocyst (Mch) phenotype. Upon N stepdown, a HetN protein with its C terminus fused to a superfolder version of green fluorescent protein (sf-GFP) or to GFP-mut2 was observed, localized first throughout the whole area of differentiating cells and later specifically on the peripheries and in the polar regions of mature heterocysts, coinciding with the location of the thylakoids. Polar localization required an N-terminal stretch comprising residues 2 to 27 that may represent an unconventional signal peptide. Anabaena strains expressing a version of HetN lacking this fragment from a mutant gene placed at the native hetN locus exhibited a mild Mch phenotype. In agreement with previous results, deletion of an internal ERGSGR sequence, which is identical to the C-terminal sequence of PatS, also led to the Mch phenotype. The subcellular localization in heterocysts of fluorescence resulting from the fusion of GFP to the C terminus of HetN suggests that a full HetN protein is present in these cells. Furthermore, the full HetN protein is more conserved among cyanobacteria than the internal ERGSGR sequence. These observations suggest that HetN anchored to thylakoid membranes in heterocysts may serve a function besides that of generating a regulatory (ERGSGR) peptide. PMID:25049089

  6. Mars Miniature Science Instruments

    NASA Technical Reports Server (NTRS)

    Kim, Soon Sam; Hayati, Samad; Lavery, David; McBrid, Karen

    2006-01-01

    For robotic Mars missions, all the science information is gathered through on-board miniature instruments that have been developed through many years of R&D. Compared to laboratory counterparts, the rover instruments require miniaturization, such as low mass (1-2 kg), low power (> 10 W) and compact (1-2 liter), yet with comparable sensitivity. Since early 1990's, NASA recognized the need for the miniature instruments and launched several instrument R&D programs, e.g., PIDDP (Planetary Instrument Definition and Development). However, until 1998, most of the instrument R&D programs supported only up to a breadboard level (TRL 3, 4) and there is a need to carry such instruments to flight qualifiable status (TU 5, 6) to respond to flight AOs (Announcement of Opportunity). Most of flight AOs have only limited time and financial resources, and can not afford such instrument development processes. To bridge the gap between instrument R&D programs and the flight instrument needs, NASA's Mars Technology Program (MTP) created advanced instrumentation program, Mars Instrument Development Project (MIDP). MIDP candidate instruments are selected through NASA Research Announcement (NRA) process [l]. For example, MIDP 161998-2000) selected and developed 10 instruments, MIDP II (2003-2005) 16 instruments, and MIDP III (2004-2006) II instruments.Working with PIs, JPL has been managing the MIDP tasks since September 1998. All the instruments being developed under MIDP have been selected through a highly competitive NRA process, and employ state-of-the-art technology. So far, four MIDP funded instruments have been selected by two Mars missions (these instruments have further been discussed in this paper).

  7. Afterword: Instruments as media, media as instruments.

    PubMed

    Rheinberger, Hans-Jörg

    2016-06-01

    The collection of essays comes under the heading of two catchwords: instruments and media. This Afterword looks at their interaction and roles in exploring the characteristics of living beings throughout history, especially their melding and gliding into each other. Before turning to the papers, I will make some more general remarks on instruments and media in scientific, and in particular, biological research. PMID:27053536

  8. Characterization of diatom-cyanobacteria symbioses on the basis of nifH, hetR and 16S rRNA sequences.

    PubMed

    Foster, Rachel A; Zehr, Jonathan P

    2006-11-01

    Richelia intracellularis is a symbiotic heterocystous cyanobacterium that is capable of forming associations with several genera of diatoms. nifH, 16S rRNA and hetR sequences were amplified and cloned from field populations of Richelia associated with Hemiaulus hauckii (N. Atlantic), with Rhizosolenia clevei (N. Pacific), and from a cultivated isolate of Calothrix associated with Chaetoceros from station ALOHA (N. Pacific). Sequence identity was highest (98.2%) among the 16S rRNA sequences, and more divergent for the hetR (83.8%) and nifH (91.1%) sequences. The hetR and nifH DNA and amino acid sequences obtained from the symbionts associated with the three different diatom genera diverged into three separate lineages supported by high bootstrap values. The data indicate that symbionts in the different hosts are distinct species or strains. Furthermore, three previously unidentified heterocystous-like nifH sequence groups recently reported from station ALOHA in the subtropical Pacific, het-1, het-2 and het-3, were linked to Richelia associated with R. clevei, H. hauckii and the Calothrix symbiont of Chaetoceros sp. respectively. PMID:17014491

  9. Piping inspection instrument carriage

    SciTech Connect

    Zollinger, W.T.; Treanor, R.C.

    1993-09-20

    This invention is comprised of a pipe inspection instrument carriage for use with a pipe crawler or other locomotion means for performing internal inspections of piping surfaces. The carriage has a front leg assembly, a rear leg assembly and a central support connecting the two assemblies and for mounting an instrument arm having inspection instruments. The instrument arm has means mounted distally thereon for axially aligning the inspection instrumentation and means for extending the inspection instruments radially outward to operably position the inspection instruments on the piping interior. Also, the carriage has means for rotating the central support and the front leg assembly with respect to the rear leg assembly so that the inspection instruments azimuthally scan the piping interior. The instrument carriage allows performance of all piping inspection operations with a minimum of moving parts, thus decreasing the likelihood of performance failure.

  10. Regional Instrumentation Centers.

    ERIC Educational Resources Information Center

    Cromie, William J.

    1980-01-01

    Focuses on the activities of regional instrumentation centers that utilize the state-of-the-art instruments and methodology in basic scientific research. The emphasis is on the centers involved in mass spectroscopy, magnetic resonance spectroscopy, lasers, and accelerators. (SA)

  11. Woodwind Instrument Maintenance.

    ERIC Educational Resources Information Center

    Sperl, Gary

    1980-01-01

    The author presents a simple maintenance program for woodwind instruments which includes the care of tendon corks, the need for oiling keys, and methods of preventing cracks in woodwind instruments. (KC)

  12. A new control system hardware architecture for the Hobby-Eberly Telescope prime focus instrument package

    NASA Astrophysics Data System (ADS)

    Ramiller, Chuck; Taylor, Trey; Rafferty, Tom H.; Cornell, Mark E.; Rafal, Marc; Savage, Richard

    2010-07-01

    The Hobby-Eberly Telescope (HET) will be undergoing a major upgrade as a precursor to the HET Dark Energy Experiment (HETDEX‡). As part of this upgrade, the Prime Focus Instrument Package (PFIP) will be replaced with a new design that supports the HETDEX requirements along with the existing suite of instruments and anticipated future additions. This paper describes the new PFIP control system hardware plus the physical constraints and other considerations driving its design. Because of its location at the top end of the telescope, the new PFIP is essentially a stand-alone remote automation island containing over a dozen subsystems. Within the PFIP, motion controllers and modular IO systems are interconnected using a local Controller Area Network (CAN) bus and the CANOpen messaging protocol. CCD cameras that are equipped only with USB 2.0 interfaces are connected to a local Ethernet network via small microcontroller boards running embedded Linux. Links to ground-level systems pass through a 100 m cable bundle and use Ethernet over fiber optic cable exclusively; communications are either direct or through Ethernet/CAN gateways that pass CANOpen messages transparently. All of the control system hardware components are commercially available, designed for rugged industrial applications, and rated for extended temperature operation down to -10 °C.

  13. Instrument Modeling and Synthesis

    NASA Astrophysics Data System (ADS)

    Horner, Andrew B.; Beauchamp, James W.

    During the 1970s and 1980s, before synthesizers based on direct sampling of musical sounds became popular, replicating musical instruments using frequency modulation (FM) or wavetable synthesis was one of the “holy grails” of music synthesis. Synthesizers such as the Yamaha DX7 allowed users great flexibility in mixing and matching sounds, but were notoriously difficult to coerce into producing sounds like those of a given instrument. Instrument design wizards practiced the mysteries of FM instrument design.

  14. The Instrumental Model

    ERIC Educational Resources Information Center

    Yeates, Devin Rodney

    2011-01-01

    The goal of this dissertation is to enable better predictive models by engaging raw experimental data through the Instrumental Model. The Instrumental Model captures the protocols and procedures of experimental data analysis. The approach is formalized by encoding the Instrumental Model in an XML record. Decoupling the raw experimental data from…

  15. Heterozygous Mapping Strategy (HetMappS) for High Resolution Genotyping-By-Sequencing Markers: A Case Study in Grapevine

    PubMed Central

    Wang, Minghui; Londo, Jason P.; Acharya, Charlotte B.; Mitchell, Sharon E.; Sun, Qi; Reisch, Bruce; Cadle-Davidson, Lance

    2015-01-01

    Genotyping by sequencing (GBS) provides opportunities to generate high-resolution genetic maps at a low genotyping cost, but for highly heterozygous species, missing data and heterozygote undercalling complicate the creation of GBS genetic maps. To overcome these issues, we developed a publicly available, modular approach called HetMappS, which functions independently of parental genotypes and corrects for genotyping errors associated with heterozygosity. For linkage group formation, HetMappS includes both a reference-guided synteny pipeline and a reference-independent de novo pipeline. The de novo pipeline can be utilized for under-characterized or high diversity families that lack an appropriate reference. We applied both HetMappS pipelines in five half-sib F1 families involving genetically diverse Vitis spp. Starting with at least 116,466 putative SNPs per family, the HetMappS pipelines identified 10,440 to 17,267 phased pseudo-testcross (Pt) markers and generated high-confidence maps. Pt marker density exceeded crossover resolution in all cases; up to 5,560 non-redundant markers were used to generate parental maps ranging from 1,047 cM to 1,696 cM. The number of markers used was strongly correlated with family size in both de novo and synteny maps (r = 0.92 and 0.91, respectively). Comparisons between allele and tag frequencies suggested that many markers were in tandem repeats and mapped as single loci, while markers in regions of more than two repeats were removed during map curation. Both pipelines generated similar genetic maps, and genetic order was strongly correlated with the reference genome physical order in all cases. Independently created genetic maps from shared parents exhibited nearly identical results. Flower sex was mapped in three families and correctly localized to the known sex locus in all cases. The HetMappS pipeline could have wide application for genetic mapping in highly heterozygous species, and its modularity provides opportunities to

  16. The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components

    PubMed Central

    Borroto-Escuela, Dasiel O.; Brito, Ismel; Romero-Fernandez, Wilber; Di Palma, Michael; Oflijan, Julia; Skieterska, Kamila; Duchou, Jolien; Van Craenenbroeck, Kathleen; Suárez-Boomgaard, Diana; Rivera, Alicia; Guidolin, Diego; Agnati, Luigi F.; Fuxe, Kjell

    2014-01-01

    G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner. However, despite the current development of experimental techniques for large-scale detection of GPCR heteromers, in order to understand their connectivity it is necessary to develop novel tools to study the global heteroreceptor networks. To provide insight into the overall topology of the GPCR heteromers and identify key players, a collective interaction network was constructed. Experimental interaction data for each of the individual human GPCR protomers was obtained manually from the STRING and SCOPUS databases. The interaction data were used to build and analyze the network using Cytoscape software. The network was treated as undirected throughout the study. It is comprised of 156 nodes, 260 edges and has a scale-free topology. Connectivity analysis reveals a significant dominance of intrafamily versus interfamily connections. Most of the receptors within the network are linked to each other by a small number of edges. DRD2, OPRM, ADRB2, AA2AR, AA1R, OPRK, OPRD and GHSR are identified as hubs. In a network representation 10 modules/clusters also appear as a highly interconnected group of nodes. Information on this GPCR network can improve our understanding of molecular integration. GPCR-HetNet has been implemented in Java and is freely available at http://www.iiia.csic.es/~ismel/GPCR-Nets/index.html. PMID:24830558

  17. Present status of aircraft instruments

    NASA Technical Reports Server (NTRS)

    1932-01-01

    This report gives a brief description of the present state of development and of the performance characteristics of instruments included in the following group: speed instruments, altitude instruments, navigation instruments, power-plant instruments, oxygen instruments, instruments for aerial photography, fog-flying instruments, general problems, summary of instrument and research problems. The items considered under performance include sensitivity, scale errors, effects of temperature and pressure, effects of acceleration and vibration, time lag, damping, leaks, elastic defects, and friction.

  18. Status of the Instrument Control Unit for EPD on-board Solar Orbiter

    NASA Astrophysics Data System (ADS)

    Sánchez Prieto, Sebastián; Da Silva, Antonio; Rodriguez Polo, Oscar; Parra Espada, Pablo; Gutierrez Molina, Oscar; Fernandez Salgado, Javier

    Solar Orbiter is the next heliospheric mission sponsored by ESA. The launch is planned for 2017 and it will be as close as 0.28 AU from the Sun. One of the instruments for Solar Orbiter is the Energetic Particle Detector (EPD) responsible for measuring energies from 2 keV to 200 MeV/n. EPD consists of four detectors, Electron Proton Telescope (EPT), High Energy Telescope (HET), SupraThermal Electrons, Ions, & Neutrals (STEIN), and Suprathermal Ion Spectrograph (SIS), plus the Instrument Control Unit called ICU. The Space Research Group of the University of Alcalá in Spain is the responsible for developing the ICU. In this work we present the development status of the ICU after the Critical Design Review. We also address the planned activities for the next year including the development of the Engineering and Qualification Model (EQM) and Flight Model (PM). Special focus is paid to the software and verification & validation activities.

  19. Review of Instrumented Indentation

    PubMed Central

    VanLandingham, Mark R.

    2003-01-01

    Instrumented indentation, also known as depth-sensing indentation or nanoindentation, is increasingly being used to probe the mechanical response of materials from metals and ceramics to polymeric and biological materials. The additional levels of control, sensitivity, and data acquisition offered by instrumented indentation systems have resulted in numerous advances in materials science, particularly regarding fundamental mechanisms of mechanical behavior at micrometer and even sub-micrometer length scales. Continued improvements of instrumented indentation testing towards absolute quantification of a wide range of material properties and behavior will require advances in instrument calibration, measurement protocols, and analysis tools and techniques. In this paper, an overview of instrumented indentation is given with regard to current instrument technology and analysis methods. Research efforts at the National Institute of Standards and Technology (NIST) aimed at improving the related measurement science are discussed.

  20. VIRUS instrument enclosures

    NASA Astrophysics Data System (ADS)

    Prochaska, T.; Allen, R.; Mondrik, N.; Rheault, J. P.; Sauseda, M.; Boster, E.; James, M.; Rodriguez-Patino, M.; Torres, G.; Ham, J.; Cook, E.; Baker, D.; DePoy, Darren L.; Marshall, Jennifer L.; Hill, G. J.; Perry, D.; Savage, R. D.; Good, J. M.; Vattiat, Brian L.

    2014-08-01

    The Visible Integral-Field Replicable Unit Spectrograph (VIRUS) instrument will be installed at the Hobby-Eberly Telescope† in the near future. The instrument will be housed in two enclosures that are mounted adjacent to the telescope, via the VIRUS Support Structure (VSS). We have designed the enclosures to support and protect the instrument, to enable servicing of the instrument, and to cool the instrument appropriately while not adversely affecting the dome environment. The system uses simple HVAC air handling techniques in conjunction with thermoelectric and standard glycol heat exchangers to provide efficient heat removal. The enclosures also provide power and data transfer to and from each VIRUS unit, liquid nitrogen cooling to the detectors, and environmental monitoring of the instrument and dome environments. In this paper, we describe the design and fabrication of the VIRUS enclosures and their subsystems.

  1. Wet chemistry instrument prototype

    NASA Technical Reports Server (NTRS)

    1974-01-01

    A wet chemistry instrument prototype for detecting amino acids in planetary soil samples was developed. The importance of amino acids and their condensation products to the development of life forms is explained. The characteristics of the instrument and the tests which were conducted to determine the materials compatibility are described. Diagrams are provided to show the construction of the instrument. Data obtained from the performance tests are reported.

  2. Instrument performance evaluation

    SciTech Connect

    Swinth, K.L.

    1993-03-01

    Deficiencies exist in both the performance and the quality of health physics instruments. Recognizing the implications of such deficiencies for the protection of workers and the public, in the early 1980s the DOE and the NRC encouraged the development of a performance standard and established a program to test a series of instruments against criteria in the standard. The purpose of the testing was to establish the practicality of the criteria in the standard, to determine the performance of a cross section of available instruments, and to establish a testing capability. Over 100 instruments were tested, resulting in a practical standard and an understanding of the deficiencies in available instruments. In parallel with the instrument testing, a value-impact study clearly established the benefits of implementing a formal testing program. An ad hoc committee also met several times to establish recommendations for the voluntary implementation of a testing program based on the studies and the performance standard. For several reasons, a formal program did not materialize. Ongoing tests and studies have supported the development of specific instruments and have helped specific clients understand the performance of their instruments. The purpose of this presentation is to trace the history of instrument testing to date and suggest the benefits of a centralized formal program.

  3. Satellite oceanography - The instruments

    NASA Technical Reports Server (NTRS)

    Stewart, R. H.

    1981-01-01

    It is pointed out that no instrument is sensitive to only one oceanographic variable; rather, each responds to a combination of atmospheric and oceanic phenomena. This complicates data interpretation and usually requires that a number of observations, each sensitive to somewhat different phenomena, be combined to provide unambiguous information. The distinction between active and passive instruments is described. A block diagram illustrating the steps necessary to convert data from satellite instruments into oceanographic information is included, as is a diagram illustrating the operation of a radio-frequency radiometer. Attention is also given to the satellites that carry the various oceanographic instruments.

  4. Instrument validation project

    SciTech Connect

    Reynolds, B.A.; Daymo, E.A.; Geeting, J.G.H.; Zhang, J.

    1996-06-01

    Westinghouse Hanford Company Project W-211 is responsible for providing the system capabilities to remove radioactive waste from ten double-shell tanks used to store radioactive wastes on the Hanford Site in Richland, Washington. The project is also responsible for measuring tank waste slurry properties prior to injection into pipeline systems, including the Replacement of Cross-Site Transfer System. This report summarizes studies of the appropriateness of the instrumentation specified for use in Project W-211. The instruments were evaluated in a test loop with simulated slurries that covered the range of properties specified in the functional design criteria. The results of the study indicate that the compact nature of the baseline Project W-211 loop does not result in reduced instrumental accuracy resulting from poor flow profile development. Of the baseline instrumentation, the Micromotion densimeter, the Moore Industries thermocouple, the Fischer and Porter magnetic flow meter, and the Red Valve Pressure transducer meet the desired instrumental accuracy. An alternate magnetic flow meter (Yokagawa) gave nearly identical results as the baseline fischer and Porter. The Micromotion flow meter did not meet the desired instrument accuracy but could potentially be calibrated so that it would meet the criteria. The Nametre on-line viscometer did not meet the desired instrumental accuracy and is not recommended as a quantitative instrument although it does provide qualitative information. The recommended minimum set of instrumentation necessary to ensure the slurry meets the Project W-058 acceptance criteria is the Micromotion mass flow meter and delta pressure cells.

  5. Space applications instrumentation systems

    NASA Technical Reports Server (NTRS)

    Minzner, R. A.; Oberholtzer, J. D.

    1972-01-01

    A compendium of resumes of 158 instrument systems or experiments, of particular interest to space applications, is presented. Each resume exists in a standardized format, permitting entries for 26 administrative items and 39 scientific or engineering items. The resumes are organized into forty groups determined by the forty spacecraft with which the instruments are associated. The resumes are followed by six different cross indexes, each organized alphabetically according to one of the following catagories: instrument name, acronym, name of principal investigator, name of organization employing the principal investigator, assigned experiment number, and spacecraft name. The resumes are associated with a computerized instrument resume search and retrieval system.

  6. Inclusion Practice Priorities Instrument.

    ERIC Educational Resources Information Center

    Montie, Jo; And Others

    This instrument was developed to assist individuals or teams to review best practice indicators regarding the development of inclusive school communities and to establish priority targets for improvement. The instrument covers three areas: (1) school community issues, (2) team issues, and (3) classroom issues. For each area, there is a review…

  7. Affective Involvement Instrument.

    ERIC Educational Resources Information Center

    Lemlech, Johanna K.

    1970-01-01

    The Affective Involvement Instrument (AII) describes and classifies affective involvement in the process of decision-making as it occurs during classroom activities such as role-playing or group discussions. The thirty-celled instrument behaviorizes the six processes involved in decision-making and combines them with the taxonomic levels of the…

  8. Developments in Electrochemical Instrumentation.

    ERIC Educational Resources Information Center

    Osteryoung, Janet

    1982-01-01

    Discusses developments in electrochemical instrumentation, including the role of computers, measurement/control instruments, present needs and future prospects. Indicates that microprocessors are used primarily for data processing, and that progress depends on noninstrumental factors such as electrode materials. (Author/JN)

  9. Thermally isolated well instruments

    SciTech Connect

    Engelder, P.D.

    1984-04-03

    A well instrument is isolated from the high temperatures of a surrounding earth formation by enclosing the instrument within a heat insulative jacket structure, preferably a dewar having spaced walls with a vacuum therebetween, with a heat sink contained in the jacket above the instrument assembly, and with a heat pipe extending upwardly from the instrument assembly to the heat sink and containing a fluid which by evaporation at a lower point and condensation at a higher point will conduct heat upwardly from the instrument assembly to the heat sink but not downwardly therebetween. The heat pipe preferably projects upwardly beyond a top portion of the insulating jacket to the location of a convector element which is exposed to the temperature of fluid or air at the outside of the insulating jacket to transmit heat from within the jacket to its exterior but not in a reverse direction.

  10. Aeronautic Instruments. Section II : Altitude Instruments

    NASA Technical Reports Server (NTRS)

    Mears, A H; Henrickson, H B; Brombacher, W G

    1923-01-01

    This report is Section two of a series of reports on aeronautic instruments (Technical Report nos. 125 to 132, inclusive). This section discusses briefly barometric altitude determinations, and describes in detail the principal types of altimeters and barographs used in aeronautics during the recent war. This is followed by a discussion of performance requirements for such instruments and an account of the methods of testing developed by the Bureau of Standards. The report concludes with a brief account of the results of recent investigations. For accurate measurements of altitude, reference must also be made to thermometer readings of atmospheric temperature, since the altitude is not fixed by atmospheric pressure alone. This matter is discussed in connection with barometric altitude determination.

  11. The DKIST Instrumentation Suite

    NASA Astrophysics Data System (ADS)

    Woeger, Friedrich

    2016-05-01

    The Daniel K. Inouye Solar Telescope with its four meter diameter aperture will be the largest telescope in the world for solar observations when it is commissioned in the year 2019. In order to harness its scientific potential immediately, DKIST will integrate five instruments that each will provide unique functionality to measure properties of the solar atmosphere at unprecedented spatial resolution.In this paper we discuss the unique capabilities in the DKIST instrument suite that consists of the Visible Broadband Imager (VBI), the Visible Spectro-Polarimeter (ViSP), the Visible Tunable Filter (VTF), the Diffraction-Limited Near-Infrared Spectro-Polarimeter (DL-NIRSP), and the Cryogenic Near-Infrared Spectro-Polarimeter (Cryo-NIRSP).In addition, we will explain the facility's approach to supporting high spatial resolution data acquisition with multiple instruments simultaneously by means of the Facility Instrument Distribution Optics. This system of wavelength separating and interchangeable beamsplitters will enable a variety of different ways to optically configure the light beam to the instruments. This approach ensures that the DKIST instruments can use their individual advantages in a multitude of different observing scenarios. The DKIST instrumentation suite will enable crucial new insights into complex physical processes that occur on spatial scales that are smaller than any solar structure observed in the past.

  12. Instrument Attitude Precision Control

    NASA Technical Reports Server (NTRS)

    Juang, Jer-Nan

    2004-01-01

    A novel approach is presented in this paper to analyze attitude precision and control for an instrument gimbaled to a spacecraft subject to an internal disturbance caused by a moving component inside the instrument. Nonlinear differential equations of motion for some sample cases are derived and solved analytically to gain insight into the influence of the disturbance on the attitude pointing error. A simple control law is developed to eliminate the instrument pointing error caused by the internal disturbance. Several cases are presented to demonstrate and verify the concept presented in this paper.

  13. Aircraft Speed Instruments

    NASA Technical Reports Server (NTRS)

    Beij, K Hilding

    1933-01-01

    This report presents a concise survey of the measurement of air speed and ground speed on board aircraft. Special attention is paid to the pitot-static air-speed meter which is the standard in the United States for airplanes. Air-speed meters of the rotating vane type are also discussed in considerable detail on account of their value as flight test instruments and as service instruments for airships. Methods of ground-speed measurement are treated briefly, with reference to the more important instruments. A bibliography on air-speed measurement concludes the report.

  14. Mass spectrometers: instrumentation

    NASA Astrophysics Data System (ADS)

    Cooks, R. G.; Hoke, S. H., II; Morand, K. L.; Lammert, S. A.

    1992-09-01

    Developments in mass spectrometry instrumentation over the past three years are reviewed. The subject is characterized by an enormous diversity of designs, a high degree of competition between different laboratories working with either different or similar techniques and by extremely rapid progress in improving analytical performance. Instruments can be grouped into genealogical charts based on their physical and conceptual interrelationships. This is illustrated using mass analyzers of different types. The time course of development of particular instrumental concepts is illustrated in terms of the s-curves typical of cell growth. Examples are given of instruments which are at the exponential, linear and mature growth stages. The prime examples used are respectively: (i) hybrid instruments designed to study reactive collisions of ions with surfaces: (ii) the Paul ion trap; and (iii) the triple quadrupole mass spectrometer. In the area of ion/surface collisions, reactive collisions such as hydrogen radical abstraction from the surface by the impinging ion are studied. They are shown to depend upon the chemical nature of the surface through the use of experiments which utilize self-assembled monolayers as surfaces. The internal energy deposited during surface-induced dissociation upon collision with different surfaces in a BEEQ instrument is also discussed. Attention is also given to a second area of emerging instrumentation, namely technology which allows mass spectrometers to be used for on-line monitoring of fluid streams. A summary of recent improvements in the performance of the rapidly developing quadrupole ion trap instrument illustrates this stage of instrument development. Improvements in resolution and mass range and their application to the characterization of biomolecules are described. The interaction of theory with experiment is illustrated through the role of simulations of ion motion in the ion trap. It is emphasized that mature instruments play a

  15. Instrument intercomparisons and assessments

    NASA Astrophysics Data System (ADS)

    Albritton, D. L.; Zander, R. J.; Farmer, C. B.; Hilsenrath, E.; Mankin, W. G.; Murcray, D. G.; Pollitt, S.; Robbins, D. E.; Roscoe, H.

    Over the past few years, several field campaigns were devoted to the goal of assessing instrument reliability, as opposed to solely obtaining data to answer a geophysical question. Some examples of the formal instrument intercomparisons that have occurred in the past decade and those that are planned for the very near future are listed chronologically. Balloon-borne techniques and instruments that address the height profiles of the trace species in the lower stratosphere are emphasized. Beginning with the most extensively studied trace constituent, the approach taken and the results obtained, are described. The current status of the measurement capabilities are summarized, and the needs for future intercomparisons and assessments are listed.

  16. Writing Instrument Profiles for Mastery of Instrumental Analysis

    ERIC Educational Resources Information Center

    King, Daniel; Fernandez, Jorge; Nalliah, Ruth

    2012-01-01

    Because of the rapidly changing nature of chemical instrumentation, students must be trained in how to learn and understand new instruments. Toward this end, students are asked to create small instrument manuals, or instrument profiles, for the major pieces of equipment studied during an instrumental analysis course. This writing-intensive process…

  17. AIR Instrument Array

    NASA Technical Reports Server (NTRS)

    Jones, I. W.; Wilson, J. W.; Maiden, D. L.; Goldhagen, P.; Shinn, J. L.

    2003-01-01

    The large number of radiation types composing the atmospheric radiation requires a complicated combination of instrument types to fully characterize the environment. A completely satisfactory combination has not as yet been flown and would require a large capital outlay to develop. In that the funds of the current project were limited to essential integration costs, an international collaboration was formed with partners from six countries and fourteen different institutions with their own financial support for their participation. Instruments were chosen to cover sensitivity to all radiation types with enough differential sensitivity to separate individual components. Some instruments were chosen as important to specify the physical field component and other instruments were chosen on the basis that they could be useful in dosimetric evaluation. In the present paper we will discuss the final experimental flight package for the ER-2 flight campaign.

  18. CALIPSO Instrument Operational

    Atmospheric Science Data Center

    2014-09-18

    CALIPSO Instrument Operational Thursday, September 11, 2014 The CALIPSO payload is back in data acquisition mode as of Wednesday, September 17, 2014.  CALIPSO data processing has returned to a nominal state, and...

  19. Low cost instrumentation amplifier

    NASA Technical Reports Server (NTRS)

    Sturman, J. C.

    1974-01-01

    Amplifier can be used for many applications requiring high input impedance and common mode rejection, low drift, and gain accuracy on order of one percent. Performance of inexpensive amplifier approaches that of some commercial instrumentation amplifiers in many specifications.

  20. NPP: The Five Instruments

    NASA Video Gallery

    The NPP satellite has 5 instruments on board: VIIRS, CERES, CrIS, ATMS, and OMPS. Each one will deliver a specific set of data helping weather prediction and climate studies. This video is a quick ...

  1. Fiber Optics Instrumentation Development

    NASA Technical Reports Server (NTRS)

    Chan, Patrick Hon Man; Parker, Allen R., Jr.; Richards, W. Lance

    2010-01-01

    This is a general presentation of fiber optics instrumentation development work being conducted at NASA Dryden for the past 10 years and recent achievements in the field of fiber optics strain sensors.

  2. Cardiovascular instrumentation for spaceflight

    NASA Technical Reports Server (NTRS)

    Schappell, R. T.; Polhemus, J. T.; Ganiaris, N. J.

    1976-01-01

    The observation mechanisms dealing with pressure, flow, morphology, temperature, etc. are discussed. The approach taken in the performance of this study was to (1) review ground and space-flight data on cardiovascular function, including earlier related ground-based and space-flight animal studies, Mercury, Gemini, Apollo, Skylab, and recent bed-rest studies, (2) review cardiovascular measurement parameters required to assess individual performance and physiological alternations during space flight, (3) perform an instrumentation survey including a literature search as well as personal contact with the applicable investigators, (4) assess instrumentation applicability with respect to the established criteria, and (5) recommend future research and development activity. It is concluded that, for the most part, the required instrumentation technology is available but that mission-peculiar criteria will require modifications to adapt the applicable instrumentation to a space-flight configuration.

  3. Aeronautic Instruments. Section III : Aircraft Speed Instruments

    NASA Technical Reports Server (NTRS)

    Hunt, Franklin L; Stearns, H O

    1923-01-01

    Part 1 contains a discussion and description of the various types of air speed measuring instruments. The authors then give general specifications and performance requirements with the results of tests on air speed indicators at the Bureau of Standards. Part 2 reports methods and laboratory apparatus used at the Bureau of Standards to make static tests. Methods are also given of combining wind tunnel tests with static tests. Consideration is also given to free flight tests. Part 3 discusses the problem of finding suitable methods for the purpose of measuring the speed of aircraft relative to the ground.

  4. Instrumentation in Arthroscopy.

    PubMed

    Barp, Eric A; Erickson, John G; Reese, Eric R

    2016-10-01

    In recent years, arthroscopic procedures of the foot and ankle have seen a significant increase in both indications and popularity. Furthermore, technological advances in video quality, fluid management, and other arthroscopy-specific instruments continue to make arthroscopic procedures more effective with reproducible outcomes. As surgeons continue to use this approach, it is important that they have a complete understanding of the instrumentation available to them, including their indications and limitations. PMID:27599434

  5. Experimenting with woodwind instruments

    NASA Astrophysics Data System (ADS)

    Lo Presto, Michael C.

    2007-05-01

    Simple experiments involving musical instruments of the woodwind family can be used to demonstrate the basic physics of vibrating air columns in resonance tubes using nothing more than straightforward measurements and data collection hardware and software. More involved experimentation with the same equipment can provide insight into the effects of holes in the tubing and other factors that make simple tubes useful as musical instruments.

  6. Modeling of Musical Instruments

    NASA Astrophysics Data System (ADS)

    Bader, Rolf; Hansen, Uwe

    Signal processing techniques in acoustics address many concerns. Included are such things as wave propagation variables, amplitude considerations, spectral content, wavelength, and phase. Phase is primarily of concern when waves interact with each other, as well as with a medium, and the imposition of boundary conditions leads to normal mode vibrations. Such conditions are prevalent in all musical instruments, and thus relevant signal processing techniques are essential to both understanding and modeling the structure of musical instruments and the sound radiated.

  7. Advanced optical instruments technology

    NASA Technical Reports Server (NTRS)

    Shao, Mike; Chrisp, Michael; Cheng, Li-Jen; Eng, Sverre; Glavich, Thomas; Goad, Larry; Jones, Bill; Kaarat, Philip; Nein, Max; Robinson, William

    1992-01-01

    The science objectives for proposed NASA missions for the next decades push the state of the art in sensitivity and spatial resolution over a wide range of wavelengths, including the x-ray to the submillimeter. While some of the proposed missions are larger and more sensitive versions of familiar concepts, such as the next generation space telescope, others use concepts, common on the Earth, but new to space, such as optical interferometry, in order to provide spatial resolutions impossible with other concepts. However, despite their architecture, the performance of all of the proposed missions depends critically on the back-end instruments that process the collected energy to produce scientifically interesting outputs. The Advanced Optical Instruments Technology panel was chartered with defining technology development plans that would best improve optical instrument performance for future astrophysics missions. At this workshop the optical instrument was defined as the set of optical components that reimage the light from the telescope onto the detectors to provide information about the spatial, spectral, and polarization properties of the light. This definition was used to distinguish the optical instrument technology issues from those associated with the telescope, which were covered by a separate panel. The panel identified several areas for optical component technology development: diffraction gratings; tunable filters; interferometric beam combiners; optical materials; and fiber optics. The panel also determined that stray light suppression instruments, such as coronagraphs and nulling interferometers, were in need of general development to support future astrophysics needs.

  8. [The instrument for thermography].

    PubMed

    Hamaguchi, Shinsuke

    2014-07-01

    Thermography is an imaging method using the instrument to detect infrared rays emitted from the body surface, and to plot them as a distribution diagram of the temperature information. Therefore, a thermographic instrument can be assumed to measure the skin temperature of the diseased region. Such an instrument is a useful device for noninvasive and objective assessment of various diseases. Examination using a thermographic instrument can assess the autonomic dysfunction by measuring the skin blood flow involved with the sympathetic innervation. Thermography is useful in assisting the determination of the therapeutic effect. However, autonomic dysfunction should be confirmed correctly with the assessment of thermatome that shows abnormal thermal distribution in the region of the disease. Thermography should make noticeable the difference between the body temperature of abnormal and normal sites, and show the alteration of temperature. Monitoring using thermography is useful to determine the effect of sympathetic nerve block. If a thermographic instrument is used, it is important that examiners should understand the function of the instrument, as well as its advantages and disadvantages. PMID:25098130

  9. HETDEX: Developing the HET's Second Generation Low Resolution Spectrograph for Probing Lyman-alpha Emitting Galaxies

    NASA Astrophysics Data System (ADS)

    Chonis, Taylor S.; Hill, G. J.; Lee, H.; Tuttle, S. E.; Vattiat, B. L.; Gebhardt, K.; Finkelstein, S. L.; Adams, J. J.; HETDEX Collaboration

    2012-01-01

    HETDEX will map the power spectrum of 0.8 million blindly discovered Lyman-alpha Emitting Galaxies (LAE) using a revolutionary new array of massively replicated fiber-fed spectrographs dubbed the Visible Integral-Field Replicable Unit Spectrograph (VIRUS). In the era of the Hobby-Eberly Telescope wide-field upgrade and VIRUS, the current Low Resolution Spectrograph (LRS) must be replaced with a fiber instrument. We discuss the development of the second generation LRS (LRS2), which is a multi-channel instrument based on the VIRUS design. In its current design phase, it is fed by a 287 fiber microlens coupled integral field unit that covers 7” x 12” with 0.62” resolution. The instrument covers 3720 Å to 4700 Å at R ≈ 1900 and 4600 Å to 7000 Å at R ≈1200. With the purpose of making the instrument ideal for follow-up observations of LAE in the HETDEX survey, we discuss the science drivers for selecting the instrument's spectral resolution. We test the utility of the instrument and pilot a future study with LRS2 by presenting R ≈ 2000 spectra taken with the VIRUS prototype spectrograph (VIRUS-P) in a high-resolution mode at the McDonald Observatory Harlan J. Smith 2.7 m telescope. These LAE were originally discovered in the HETDEX Pilot Survey and their Lyman-alpha line profiles are constrained by near-infrared observations of rest-frame optical emission lines that set the systemic redshift of the galaxies. We discuss the velocity offsets of the Lyman-alpha line from the systemic line center and compare the line profiles to theoretical predictions and to similar observations for Lyman-break galaxies. Our observations provide an example of how LRS2 can be used to probe Lyman-alpha emission in 2 < z < 3 star forming galaxies.

  10. Aeronautic Instruments. Section V : Power Plant Instruments

    NASA Technical Reports Server (NTRS)

    Washburn, G E; Sylvander, R C; Mueller, E F; Wilhelm, R M; Eaton, H N; Warner, John A C

    1923-01-01

    Part 1 gives a general discussion of the uses, principles, construction, and operation of airplane tachometers. Detailed description of all available instruments, both foreign and domestic, are given. Part 2 describes methods of tests and effect of various conditions encountered in airplane flight such as change of temperature, vibration, tilting, and reduced air pressure. Part 3 describes the principal types of distance reading thermometers for aircraft engines, including an explanation of the physical principles involved in the functioning of the instruments and proper filling of the bulbs. Performance requirements and testing methods are given and a discussion of the source of error and results of tests. Part 4 gives methods of tests and calibration, also requirements of gauges of this type for the pressure measurement of the air pressure in gasoline tanks and the engine oil pressure on airplanes. Part 5 describes two types of gasoline gauges, the float type and the pressure type. Methods of testing and calibrating gasoline depth gauges are given. The Schroeder, R. A. E., and the Mark II flowmeters are described.

  11. The keyboard instruments.

    PubMed

    Manchester, Ralph A

    2014-06-01

    Now that the field of performing arts medicine has been in existence for over three decades, we are approaching a key point: we should start to see more articles that bring together the data that have been collected from several studies in order to draw more robust conclusions. Review articles and their more structured relative, the meta-analysis, can help to improve our understanding of a particular topic, comparing and synthesizing the results of previous research that has been done on that subject area. One way this could be done would be to review the research that has been carried out on the performance-related problems associated with playing a particular instrument or group of instruments. While I am not going to do that myself, I hope that others will. In this editorial, I will do a very selective review of the playing-related musculoskeletal disorders (PRMDs) associated with one instrument group (the keyboard instruments), focusing on the most played instrument in that group (the piano;). PMID:24925170

  12. Issues in Shuttle System Instrumentation

    NASA Technical Reports Server (NTRS)

    James, George

    2004-01-01

    The purose: a) Customer's perspective on Space Shuttle Return to Flight instrumentation; b) Focus on the difficult instrumentation issues; and c) Enable a discussion of new technologies (i.e.- NANO/MEMS/Small Tech) that could enhance Shuttle instrumentation posture. The T-10 Umbilical allows the vehicle instruments to be monitored and recorded prior to each launch and retract during launch.Launch Complex Instrumentation are instruments needed for assessment of Launch Commit Criteria (LCC) Salt-air and launch environments are issues. Instrumentation (Drag-On Instrumentation) can be added as needed to the vehicle for non-flight use. The current Roll-out Fatigue Testing is a primary example.

  13. Volume phase holographic grating performance on the VIRUS-P instrument

    NASA Astrophysics Data System (ADS)

    Adams, Joshua J.; Hill, Gary J.; MacQueen, Phillip J.

    2008-07-01

    The Visible Integral-field Replicable Unit Spectrograph Prototype (VIRUS-P) has been in operation on the Harlan J Smith 2.7m Telescope at McDonald Observatory since October of 2006. The prototype was created to test the design and science capabilities of the full VIRUS instrument, wherein 150 copies of the spectrograph will be installed on the Hobby Eberly Telescope (HET). We here discuss the specialized test bench built to assess the blue optimized Volume Phase Holographic (VPH) grating performance. We also give lab and on-telescope efficiency measurements for three such gratings in the wavelength range 3400-6800Å. Two sources of stray light relevant to most spectrograph designs are also discussed.

  14. Eigenvalues and musical instruments

    NASA Astrophysics Data System (ADS)

    Howle, V. E.; Trefethen, Lloyd N.

    2001-10-01

    Most musical instruments are built from physical systems that oscillate at certain natural frequencies. The frequencies are the imaginary parts of the eigenvalues of a linear operator, and the decay rates are the negatives of the real parts, so it ought to be possible to give an approximate idea of the sound of a musical instrument by a single plot of points in the complex plane. Nevertheless, the authors are unaware of any such picture that has ever appeared in print. This paper attempts to fill that gap by plotting eigenvalues for simple models of a guitar string, a flute, a clarinet, a kettledrum, and a musical bell. For the drum and the bell, simple idealized models have eigenvalues that are irrationally related, but as the actual instruments have evolved over the generations, the leading five or six eigenvalues have moved around the complex plane so that their relative positions are musically pleasing.

  15. Nonmetallic Diaphragms for Instruments

    NASA Technical Reports Server (NTRS)

    Eaton, H N; Buckingham, C T

    1925-01-01

    This report, the second of a series of reports relating to the general subject of instrument diaphragms. The first report of the series was published as Technical Report no. 165, "diaphragms for aeronautic instruments," and comprised an outline of historical developments and theoretical principles. The present report relates entirely to nonmetallic diaphragms, the use of which in certain types of pressure elements has been increasing for some time. Little, if any, information has been available to aid the designer of instruments using this form of pressure element. It was to attempt to meet the need for such information that the investigation reported in this paper was undertaken. The report describes the various materials which have been used as nonmetallic diaphragms, discusses the factors which affect the performance of the diaphragms and gives the results of tests made for the purpose of investigating the effect produced by these factors.

  16. Ozone Monitoring Instrument

    NASA Astrophysics Data System (ADS)

    de Vries, Johan

    The Ozone Monitoring Instrument is a trace gas monitoring instrument in the line of GOME (ERS-2) and Sciamachy (ENVISAT). Following these instruments, OMI provides UV-visible spectroscopy with a resolution sufficient to separate out the various absorbing trace gases (using DOAS or `Full' retrieval), but shaped as an imaging spectrometer. This means that a two dimensional detector is used where one dimension records the spectrum and the other images the swath. The scanning mechanism from the GOME and Sciamachy is not required anymore and there are considerable advantages with respect to simultaneous measurement of swath pixels, polarisation and obtainable swath width. The OMI consortium for a phase B is formed by Fokker Space & Systems and TPD in the Netherlands and VTT in Finland. In the presentation UV-visible atmospheric remote sensing will be placed in perspective and the OMI will be explaned.

  17. Virtual Sensor Test Instrumentation

    NASA Technical Reports Server (NTRS)

    Wang, Roy

    2011-01-01

    Virtual Sensor Test Instrumentation is based on the concept of smart sensor technology for testing with intelligence needed to perform sell-diagnosis of health, and to participate in a hierarchy of health determination at sensor, process, and system levels. A virtual sensor test instrumentation consists of five elements: (1) a common sensor interface, (2) microprocessor, (3) wireless interface, (4) signal conditioning and ADC/DAC (analog-to-digital conversion/ digital-to-analog conversion), and (5) onboard EEPROM (electrically erasable programmable read-only memory) for metadata storage and executable software to create powerful, scalable, reconfigurable, and reliable embedded and distributed test instruments. In order to maximize the efficient data conversion through the smart sensor node, plug-and-play functionality is required to interface with traditional sensors to enhance their identity and capabilities for data processing and communications. Virtual sensor test instrumentation can be accessible wirelessly via a Network Capable Application Processor (NCAP) or a Smart Transducer Interlace Module (STIM) that may be managed under real-time rule engines for mission-critical applications. The transducer senses the physical quantity being measured and converts it into an electrical signal. The signal is fed to an A/D converter, and is ready for use by the processor to execute functional transformation based on the sensor characteristics stored in a Transducer Electronic Data Sheet (TEDS). Virtual sensor test instrumentation is built upon an open-system architecture with standardized protocol modules/stacks to interface with industry standards and commonly used software. One major benefit for deploying the virtual sensor test instrumentation is the ability, through a plug-and-play common interface, to convert raw sensor data in either analog or digital form, to an IEEE 1451 standard-based smart sensor, which has instructions to program sensors for a wide variety of

  18. Inspector-instrument interface in portable NDA instrumentation

    SciTech Connect

    Halbig, J.K.; Klosterbuer, S.F.

    1981-01-01

    Recent electronics technology advances make it possible to design sophisticated instruments in small packages for convenient field implementation. This report describes an inspector-instrument interface design which allows communication of procedures, responses, and results between the instrument and user. The interface has been incorporated into new spent-fuel instrumentation and a battery-powered multichannel analyzer.

  19. Inspector-instrument interface in portable NDA instrumentation

    SciTech Connect

    Halbig, J.K.; Klosterbuer, S.F.

    1981-01-01

    Recent electronics technology advances make it possible to design sophisticated instruments in small packages for convenient field implementation. An inspector-instrument interface design that allows communication of procedures, responses, and results between the instrument and user is presented. This capability has been incorporated into new spent-fuel instrumentation and a battery-powered multichannel analyzer.

  20. [Hardening of dental instruments].

    PubMed

    Gerasev, G P

    1981-01-01

    The possibility of prolonging the service life of stomatological instruments by the local hardening of their working parts is discussed. Such hardening should be achieved by using hard and wear-resistant materials. The examples of hardening dental elevators and hard-alloy dental drills are given. New trends in the local hardening of instruments are the treatment of their working parts with laser beams, the application of coating on their surface by the gas-detonation method. The results of research work and trials are presented. PMID:7300627

  1. Advanced sensors and instrumentation

    NASA Technical Reports Server (NTRS)

    Calloway, Raymond S.; Zimmerman, Joe E.; Douglas, Kevin R.; Morrison, Rusty

    1990-01-01

    NASA is currently investigating the readiness of Advanced Sensors and Instrumentation to meet the requirements of new initiatives in space. The following technical objectives and technologies are briefly discussed: smart and nonintrusive sensors; onboard signal and data processing; high capacity and rate adaptive data acquisition systems; onboard computing; high capacity and rate onboard storage; efficient onboard data distribution; high capacity telemetry; ground and flight test support instrumentation; power distribution; and workstations, video/lighting. The requirements for high fidelity data (accuracy, frequency, quantity, spatial resolution) in hostile environments will continue to push the technology developers and users to extend the performance of their products and to develop new generations.

  2. Instrumentation in medical systems

    SciTech Connect

    Chu, W.T.

    1995-05-01

    The demand for clinical use of accelerated heavy charged-particle (proton and light-ion) beams for cancer treatment is now burgeoning worldwide. Clinical trials are underway at more than a dozen accelerators. Several hospital-based accelerator facilities dedicated to radiation treatment of human cancer have been constructed, and their number is growing. Many instruments in medical systems have been developed for modifying extracted particle beams for clinical application, monitoring the delivery of the treatment beams, and controlling the treatment processes to ensure patient safety. These in turn demand new developments of instruments in controlling beam extraction, beam tuning, and beam transportation at the medical systems.

  3. Lightning Instrumentation at KSC

    NASA Technical Reports Server (NTRS)

    Colon, Jose L.; Eng, D.

    2003-01-01

    This report summarizes lightning phenomena with a brief explanation of lightning generation and lightning activity as related to KSC. An analysis of the instrumentation used at launching Pads 39 A&B for measurements of lightning effects is included with alternatives and recommendations to improve the protection system and upgrade the actual instrumentation system. An architecture for a new data collection system to replace the present one is also included. A novel architecture to obtain lightning current information from several sensors using only one high speed recording channel while monitoring all sensors to replace the actual manual lightning current recorders and a novel device for the protection system are described.

  4. Ocean Observation Instrument

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Airborne Ocean Color Imager (AOCI) was developed by Daedalus Enterprises, Inc. for Ames Research Center under a Small Business Innovation Research (SBIR) contract as a simulator for an advanced oceanographic satellite instrument. The instrument measures water temperature and detects water color in nine wavelengths. Water color indicates chlorophyll content or phytoplankton. After EOCAP assistance and technical improvements, the AOCI was successfully commercialized by Daedalus Enterprises, Inc. One version provides commercial fishing fleets with information about fish locations, and the other is used for oceanographic research.

  5. Interfacing to accelerator instrumentation

    SciTech Connect

    Shea, T.J.

    1995-12-31

    As the sensory system for an accelerator, the beam instrumentation provides a tremendous amount of diagnostic information. Access to this information can vary from periodic spot checks by operators to high bandwidth data acquisition during studies. In this paper, example applications will illustrate the requirements on interfaces between the control system and the instrumentation hardware. A survey of the major accelerator facilities will identify the most popular interface standards. The impact of developments such as isochronous protocols and embedded digital signal processing will also be discussed.

  6. Microtechnology for instrumentation

    SciTech Connect

    Mariella, R.

    1998-01-01

    For the last two decades, the majority of research and development at LLNL in microtechnology has focused on photonics devices and bulk micromachining, including miccroelectro-mechanical systems and associated areas. For the last ten years, we have used these capabilities to address our analytical instrumentation needs. Just as the miniature photonics have enable the fabrication of analytical instruments that are either higher performance, smaller, more portable, or are combinations of these. Examples of these are our portable thermal cyclers for DNA analysis, our hand-held gas chromatograph, our flow-stream-waveguide-based flow cytometer, and our etched-microchannel electrophoresis systems. This presentation will describe these and related developments.

  7. Spectroelectrochemical Instrument Measures TOC

    NASA Technical Reports Server (NTRS)

    Kounaves, Sam

    2011-01-01

    A spectroelectrochemical instrument has been developed for measuring the total organic carbon (TOC) content of an aqueous solution. Measurements of TOC are frequently performed in environmental, clinical, and industrial settings. Until now, techniques for performing such measurements have included, various ly, the use of hazardous reagents, ultraviolet light, or ovens, to promote reactions in which the carbon contents are oxidized. The instrument now being developed is intended to be a safer, more economical means of oxidizing organic carbon and determining the TOC levels of aqueous solutions and for providing a low power/mass unit for use in planetary missions.

  8. Instrumentation in wind tunnels

    NASA Technical Reports Server (NTRS)

    Takashima, K.

    1986-01-01

    Requirements in designing instrumentation systems and measurements of various physical quantities in wind tunnels are surveyed. Emphasis is given to sensors used for measuring pressure, temperature, and angle, and the measurements of air turbulence and boundary layers. Instrumentation in wind tunnels require accuracy, fast response, diversity and operational simplicity. Measurements of force, pressure, attitude angle, free flow, pressure distribution, and temperature are illustrated by a table, and a block diagram. The LDV (laser Doppler velocimeter) method for measuring air turbulence and flow velocity and measurement of skin friction and flow fields using laser holograms are discussed. The future potential of these techniques is studied.

  9. Standard NIM instrumentation system

    SciTech Connect

    Not Available

    1990-05-01

    NIM is a standard modular instrumentation system that is in wide use throughout the world. As the NIM system developed and accommodations were made to a dynamic instrumentation field and a rapidly advancing technology, additions, revisions and clarifications were made. These were incorporated into the standard in the form of addenda and errata. This standard is a revision of the NIM document, AEC Report TID-20893 (Rev. 4) dated July 1974. It includes all the addenda and errata items that were previously issued as well as numerous additional items to make the standard current with modern technology and manufacturing practice.

  10. Comparison of the antiinflammatory effects of Drosera rotundifolia and Drosera madagascariensis in the HET-CAM assay.

    PubMed

    Paper, Dietrich H; Karall, Elisabeth; Kremser, Michaela; Krenn, Liselotte

    2005-04-01

    The antiinflammatory effects of ethanol and aqueous extracts from Drosera rotundifolia and from Drosera madagascariensis were compared in vivo in the HET-CAM assay. Both extracts from D. rotundifolia and the ethanol extract from D. madagascariensis showed remarkable efficacy at doses of 500 microg/pellet. The inhibition of the inflammation by the extracts was stronger than that by 50 microg hydrocortisone/pellet. In contrast, there was only a very weak effect observed at a dose of 500 microg/pellet of the water extract from D. madagascariensis. The chemical analyses of the extracts showed that the effect cannot be attributed to naphthoquinones, but might be due to flavonoids. Ellagic acid obviously plays an important role in the antiangiogenic effect of the Drosera extracts. PMID:16041727

  11. Synthesis and anticancer activity evaluation of 3,4-mono- and bicyclosubstituted N-(het)aryl trifluoromethyl succinimides

    PubMed Central

    Luzina, Elena L.; Popov, Anatoliy V.

    2014-01-01

    Novel trifluoromethylated mono- and bicyclic succinimides derived from trifluoromethylmaleic anhydride were synthesized using cyclopentadiene or 2,3-dimethylbutadiene and (het)arylamines. The biological activity of these compounds was evaluated using prediction methods and experimental studies. This series of new trifluoromethyl succinimides (3a,b and 6a–c) were tested by the National Cancer Institute (NCI, Bethesda, USA) by Program NCI-60 DTP Human Tumor Cell Line Screen at a single high dose (10−5 M). Imides revealed activity on Leukemia cell lines (RPMI-8226 - myeloma cell line), Non-Small Cell Lung Cancer cell lines (A549/ATCC - lung carcinoma epithelial cells) and Renal cancer cell lines (A498 and SN12C). PMID:25400294

  12. Flaws of drug instrumentalization.

    PubMed

    Swendsen, Joel; Le Moal, Michel

    2011-12-01

    The adaptive use of drugs, or "drug instrumentalization," is presented as a reality that the scientific literature has largely ignored. In this commentary, we demonstrate why this concept has limited value from the standpoint of nosology, why it should not be viewed as "adaptive," and why it has dangerous implications for policy and public health efforts. PMID:22074977

  13. Rain radar instrument definition

    NASA Astrophysics Data System (ADS)

    Vincent, Nicolas; Chenebault, J.; Suinot, Noel; Mancini, Paolo L.

    1996-12-01

    As a result of a pre-phase a study, founded by ESA, this paper presents the definition of a spaceborne Rain Radar, candidate instrument for earth explorer precipitation mission. Based upon the description of user requirements for such a dedicated mission, a mission analysis defines the most suitable space segment. At system level, a parametric analysis compares pros and cons of instrument concepts associated with rain rate retrieval algorithms in order to select the most performing one. Several trade-off analysis at subsystem level leads then to the definition of the proposed design. In particular, as pulse compression is implemented in order to increase the radar sensitivity, the selected method to achieve a pulse response with a side-lobe level below--60 dB is presented. Antenna is another critical rain radar subsystem and several designs are com pared: direct radiating array, single or dual reflector illuminated by single or dual feed arrays. At least, feasibility of centralized amplification using TWTA is compared with criticality of Tx/Rx modules for distributed amplification. Mass and power budgets of the designed instrument are summarized as well as standard deviations and bias of simulated rain rate retrieval profiles. The feasibility of a compliant rain radar instrument is therefore demonstrated.

  14. Instrument Measures Ocular Counterrolling

    NASA Technical Reports Server (NTRS)

    Levitan, Barry M.; Reschke, Millard F.; Spector, Lawrence N.

    1991-01-01

    Compact, battery-powered, noninvasive unit replaces several pieces of equipment and operator. Instrument that looks like pair of goggles with small extension box measures ocular counterrotation. Called "otolith tilt-translation reinterpretation" (OTTR) goggles, used in studies of space motion sickness. Also adapted to use on Earth and determine extent of impairment in patients who have impaired otolith functions.

  15. Elementary Instrumental Music Program.

    ERIC Educational Resources Information Center

    Smith, Dolores A.

    THE FOLLOWING IS THE FULL TEXT OF THIS DOCUMENT: Our former Elementary Instrumental Music Program for 4th-6th graders was costly and ineffective. Students were bused to a high school in the middle of the instructional day--costs (time and transportation) were not compensatory with the program, which was experiencing a significant drop-out rate.…

  16. HARMONI instrument control electronics

    NASA Astrophysics Data System (ADS)

    Gigante, José V.; Rodríguez Ramos, Luis F.; Zins, Gerard; Schnetler, Hermine; Pecontal, Arlette; Herreros, José Miguel; Clarke, Fraser; Bryson, Ian; Thatte, Niranjan

    2014-07-01

    HARMONI is an integral field spectrograph working at visible and near-infrared wavelengths over a range of spatial scales from ground layer corrected to fully diffraction-limited. The instrument has been chosen to be part of the first-light complement at the European Extremely Large Telescope (E-ELT). This paper describes the instrument control electronics to be developed at IAC. The large size of the HARMONI instrument, its cryogenic operation, and the fact that it must operate with enhanced reliability is a challenge from the point of view of the control electronics design. The present paper describes a design proposal based on the current instrument requirements and intended to be fully compliant with the ESO E-ELT standards, as well as with the European EMC and safety standards. The modularity of the design and the use of COTS standard hardware will benefit the project in several aspects, as reduced costs, shorter schedule by the use of commercially available components, and improved quality by the use of well proven solutions.

  17. Analytical Instrument Obsolescence Examined.

    ERIC Educational Resources Information Center

    Haggin, Joseph

    1982-01-01

    The threat of instrument obsolescence and tight federal budgets have conspired to threaten the existence of research analytical laboratories. Despite these and other handicaps most existing laboratories expect to keep operating in support of basic research, though there may be serious penalties in the future unless funds are forthcoming. (Author)

  18. Neutron instrumentation for biology

    SciTech Connect

    Mason, S.A.

    1994-12-31

    In the October 1994 round of proposals at the ILL, the external biology review sub- committee was asked to allocate neutron beam time to a wide range of experiments, on almost half the total number of scheduled neutron instruments: on 3 diffractometers, on 3 small angle scattering instruments, and on some 6 inelastic scattering spectrometers. In the 3.5 years since the temporary reactor shutdown, the ILL`s management structure has been optimized, budgets and staff have been trimmed, the ILL reactor has been re-built, and many of the instruments up-graded, many powerful (mainly Unix) workstations have been introduced, and the neighboring European Synchrotron Radiation Facility has established itself as the leading synchrotron radiation source and has started its official user program. The ILL reactor remains the world`s most intense dedicated neutron source. In this challenging context, it is of interest to review briefly the park of ILL instruments used to study the structure and energetics of small and large biological systems. A brief summary will be made of each class of experiments actually proposed in the latest ILL proposal round.

  19. Instrument for Textbook Assessment.

    ERIC Educational Resources Information Center

    Huetteman, Julie Doidge

    An instrument to assist in assessing textbooks was created to provide a concise format for comparison and evaluation. Textbook characteristics were selected to illustrate content and proportion of characteristics of textbooks. Nine textbook characteristics were selected for quantifying the content areas of textbooks: (1) number of pages in the…

  20. Music: Instrumental Techniques, Percussion.

    ERIC Educational Resources Information Center

    Pearl, Jesse

    A course in introduction to music emphasizing harmony is presented. The approach used is a laboratory approach in which pupils will develop skill in playing percussion instruments, sing, listen to, read and compose music with emphasis on elementary concepts of harmony. Course objectives include: (1) The student will recognize duple, triple,…

  1. Music: Instrumental Techniques, Strings.

    ERIC Educational Resources Information Center

    Ryan, Philip

    A course in music which emphasizes harmony is presented. The approach used is a laboratory one in which pupils will develop skill in playing orchestral string instruments, sing, listen to, read and compose music with emphasis on elementary concepts of harmony. Course objectives include: (1) The student will select the title of a familiar melody…

  2. Portable dynamic fundus instrument

    NASA Technical Reports Server (NTRS)

    Taylor, Gerald R. (Inventor); Meehan, Richard T. (Inventor); Hunter, Norwood R. (Inventor); Caputo, Michael P. (Inventor); Gibson, C. Robert (Inventor)

    1992-01-01

    A portable diagnostic image analysis instrument is disclosed for retinal funduscopy in which an eye fundus image is optically processed by a lens system to a charge coupled device (CCD) which produces recordable and viewable output data and is simultaneously viewable on an electronic view finder. The fundus image is processed to develop a representation of the vessel or vessels from the output data.

  3. Instrument for assaying radiation

    DOEpatents

    Coleman, Jody Rustyn; Farfan, Eduardo B.

    2016-03-22

    An instrument for assaying radiation includes a flat panel detector having a first side opposed to a second side. A collimated aperture covers at least a portion of the first side of the flat panel detector. At least one of a display screen or a radiation shield may cover at least a portion of the second side of the flat panel detector.

  4. AC resistance measuring instrument

    DOEpatents

    Hof, P.J.

    1983-10-04

    An auto-ranging AC resistance measuring instrument for remote measurement of the resistance of an electrical device or circuit connected to the instrument includes a signal generator which generates an AC excitation signal for application to a load, including the device and the transmission line, a monitoring circuit which provides a digitally encoded signal representing the voltage across the load, and a microprocessor which operates under program control to provide an auto-ranging function by which range resistance is connected in circuit with the load to limit the load voltage to an acceptable range for the instrument, and an auto-compensating function by which compensating capacitance is connected in shunt with the range resistance to compensate for the effects of line capacitance. After the auto-ranging and auto-compensation functions are complete, the microprocessor calculates the resistance of the load from the selected range resistance, the excitation signal, and the load voltage signal, and displays of the measured resistance on a digital display of the instrument. 8 figs.

  5. AC Resistance measuring instrument

    DOEpatents

    Hof, Peter J.

    1983-01-01

    An auto-ranging AC resistance measuring instrument for remote measurement of the resistance of an electrical device or circuit connected to the instrument includes a signal generator which generates an AC excitation signal for application to a load, including the device and the transmission line, a monitoring circuit which provides a digitally encoded signal representing the voltage across the load, and a microprocessor which operates under program control to provide an auto-ranging function by which range resistance is connected in circuit with the load to limit the load voltage to an acceptable range for the instrument, and an auto-compensating function by which compensating capacitance is connected in shunt with the range resistance to compensate for the effects of line capacitance. After the auto-ranging and auto-compensation functions are complete, the microprocessor calculates the resistance of the load from the selected range resistance, the excitation signal, and the load voltage signal, and displays of the measured resistance on a digital display of the instrument.

  6. Experimenting with Woodwind Instruments

    ERIC Educational Resources Information Center

    LoPresto, Michael C.

    2007-01-01

    Simple experiments involving musical instruments of the woodwind family can be used to demonstrate the basic physics of vibrating air columns in resonance tubes using nothing more than straightforward measurements and data collection hardware and software. More involved experimentation with the same equipment can provide insight into the effects…

  7. University Reactor Instrumentation Program

    SciTech Connect

    Vernetson, W.G.

    1992-11-01

    Recognizing that the University Reactor Instrumentation Program was developed in response to widespread needs in the academic community for modernization and improvement of research and training reactors at institutions such as the University of Florida, the items proposed to be supported by this grant over its two year period have been selected as those most likely to reduce foreed outages, to meet regulatory concerns that had been expressed in recent years by Nuclear Regulatory Commission inspectors or to correct other facility problems and limitations. Department of Energy Grant Number DE-FG07-90ER129969 was provided to the University of Florida Training Reactor(UFTR) facility through the US Department of Energy's University Reactor Instrumentation Program. The original proposal submitted in February, 1990 requested support for UFTR facility instrumentation and equipment upgrades for seven items in the amount of $107,530 with $13,800 of this amount to be the subject of cost sharing by the University of Florida and $93,730 requested as support from the Department of Energy. A breakdown of the items requested and total cost for the proposed UFTR facility instrumentation and equipment improvements is presented.

  8. Instrument measures cloud cover

    NASA Technical Reports Server (NTRS)

    Laue, E. G.

    1981-01-01

    Eight solar sensing cells comprise inexpensive monitoring instrument. Four cells always track Sun while other four face sky and clouds. On overcast day, cloud-irradiance sensors generate as much short-circuit current as Sun sensor cells. As clouds disappear, output of cloud sensors decreases. Ratio of two sensor type outputs determines fractional cloud cover.

  9. Process Instrumentation. Teacher Edition.

    ERIC Educational Resources Information Center

    Brown, A. O., III; Fowler, Malcolm

    This module provides instructional materials that are designed to help teachers train students in job skills for entry-level jobs as instrumentation technicians. This text addresses the basics of troubleshooting control loops, and the transducers, transmitters, signal conditioners, control valves, and controllers that enable process systems to…

  10. Music: Instrumental Techniques, Woodwinds.

    ERIC Educational Resources Information Center

    Baker, Melvin

    A course in introduction to music emphasizing modes and forms is presented. The approach used is a laboratory approach in which pupils will develop skill in playing wood-wind instruments, sing, listen to, read and compose music with emphasis on identification of elementary concepts of mode and form. Course objectives include: (1) pupil will select…

  11. University Reactor Instrumentation Grant

    SciTech Connect

    S. M. Bajorek

    2000-02-01

    A noble gas air monitoring system was purchased through the University Reactor Instrumentation Grant Program. This monitor was installed in the Kansas State TRIGA reactor bay at a location near the top surface of the reactor pool according to recommendation by the supplier. This system is now functional and has been incorporated into the facility license.

  12. Designing Intelligent Instruments

    NASA Astrophysics Data System (ADS)

    Knuth, Kevin H.; Erner, Philip M.; Frasso, Scott

    2007-11-01

    Remote science operations require automated systems that can both act and react with minimal human intervention. One such vision is that of an intelligent instrument that collects data in an automated fashion, and based on what it learns, decides which new measurements to take. This innovation implements experimental design and unites it with data analysis in such a way that it completes the cycle of learning. This cycle is the basis of the Scientific Method. The three basic steps of this cycle are hypothesis generation, inquiry, and inference. Hypothesis generation is implemented by artificially supplying the instrument with a parameterized set of possible hypotheses that might be used to describe the physical system. The act of inquiry is handled by an inquiry engine that relies on Bayesian adaptive exploration where the optimal experiment is chosen as the one which maximizes the expected information gain. The inference engine is implemented using the nested sampling algorithm, which provides the inquiry engine with a set of posterior samples from which the expected information gain can be estimated. With these computational structures in place, the instrument will refine its hypotheses, and repeat the learning cycle by taking measurements until the system under study is described within a pre-specified tolerance. We will demonstrate our first attempts toward achieving this goal with an intelligent instrument constructed using the LEGO MINDSTORMS NXT robotics platform.

  13. Instrumentation for interstellar exploration

    NASA Astrophysics Data System (ADS)

    Gruntman, M.

    The time has arrived for designing, building, and instrumenting a spacecraft for a dedicated foray into interstellar space surrounding our star, the Sun. This region was probed in the past by remote techniques and it will be explored in situ by the Interstellar Probe mission. The mission will significantly advance our understanding of the nature of the local interstellar medium and explore the distant frontier of the solar system by revealing the details of the interaction between the Sun and Galaxy. This mission will also be an important practical step toward interstellar flight of the future. Reaching interstellar space in reasonable time requires high escape velocities and will likely be enabled by non-chemical propulsion such as nuclear-powered electric propulsion or solar sailing. Unusually high spacecraft velocities, enormous distances from the Sun, and non-chemical propulsion will significantly influence the design of the mission, spacecraft and scientific instrumentation. We will review measurement objectives of the first mission into interstellar space and outline constrains on the instrumentation. Measurement of particles, fields, and dust in the interstellar medium will be complemented by search for complex molecules and remote sensing capabilities in various spectral bands. A "look" back at our solar system will also be a glimpse of wh at a flyby mission of the distant future would encounter in approaching another star. The instrumentation for interstellar exploration presents numerous challenges. Mass, telemetry, and power constraints would place a premium on miniaturization and autonom . There are, however,y physical limits on how small the sensors could be. New instrument concepts may be required to achieve the desired measurement capabilities under the stringent constraints of a realistic interstellar mission.

  14. Instrumentation for interstellar exploration

    NASA Astrophysics Data System (ADS)

    Gruntman, Mike

    2004-01-01

    The time has arrived for designing, building, and instrumenting a spacecraft for a dedicated foray into the galactic environment surrounding our star, the sun. This region was probed in the past by remote techniques and it will be explored in situ by the NASA's planned Interstellar Probe mission. The mission will significantly advance our understanding of the nature of the local interstellar medium and explore the distant frontier of the solar system by revealing the details of the interaction between the sun and the Galaxy. This mission will also be an important practical step toward interstellar flight of the future. Reaching interstellar space in reasonable time requires high escape velocities and will likely be enabled by non-chemical propulsion such as nuclear-powered electric propulsion or solar sailing. Unusually high spacecraft velocities, enormous distances from the Sun, and non-chemical propulsion will significantly influence design of the mission, spacecraft, and scientific instrumentation. We will review measurement objectives of the first dedicated mission into interstellar space and outline constraints on the instrumentation. Measurement of particles, fields, and dust in the interstellar medium will be complemented by search for complex organic molecules and remote sensing capabilities in various spectral bands. A "look" back at our solar system will also be a glimpse of what a truly-interstellar mission of the distant future would encounter in approaching a target star. The instrumentation for interstellar exploration presents numerous challenges. Mass, telemetry, and power constraints would place a premium on miniaturization and autonomy. There are, however, physical limits on how small the sensors could be. New instrument concepts may be required to achieve the desired measurement capabilities under the stringent constraints of a realistic interstellar mission.

  15. Instrument Control Unit for the EPD on board Solar Orbiter

    NASA Astrophysics Data System (ADS)

    Sánchez Prieto, S.; Prieto Mateo, M.; Rodríguez Polo; Gutiérrez Molina; Parra Espada, P.; da Silva Fariña, A.

    2013-05-01

    Undoubtedly, Solar Orbiter is the leading mission of the European Space Agency for studying the Sun in the current decade. Its elliptical orbit around the Sun, with a perihelion as low as 0.28 AU and with an increasing inclination of up to more than 25° with respect to the solar equator, makes it ideal for an in-situ environmental study. This study will provide the key to determine how does the Sun create and control the heliosphere, which is the main objective of this mission. One of the ten instruments that are part of the Solar Orbiter's payload is the Energetic Particle Detector (EPD). Its main objective is to measure the composition, timing and distribution functions of suprathermal and energetic particles. Scientific topics to be addressed include the sources, acceleration mechanisms, and transport processes of these particles. EPD is composed of four sensors (STEIN, EPT, HET and SIS), distributed along the spacecraft, and an Instrument Control Unit or ICU. The sensors are able to measure electrons in the energy range from 0.002 to 20 MeV, protons from 0.003 to 100 MeV and nucleons of He to Fe in the range of 0.008 to 200 MeV/n. The ICU is the sole interface with the spacecraft, providing control, communication and data processing to the sensors. Due to the strong reliability requirements associated to the ICU, special care has been taken in the hardware, software and mechanical designs. In this work the development status of the ICU, together with its hardware and software architectures, design decisions and tools are presented.

  16. Data acquisition instruments: Psychopharmacology

    SciTech Connect

    Hartley, D.S. III

    1998-01-01

    This report contains the results of a Direct Assistance Project performed by Lockheed Martin Energy Systems, Inc., for Dr. K. O. Jobson. The purpose of the project was to perform preliminary analysis of the data acquisition instruments used in the field of psychiatry, with the goal of identifying commonalities of data and strategies for handling and using the data in the most advantageous fashion. Data acquisition instruments from 12 sources were provided by Dr. Jobson. Several commonalities were identified and a potentially useful data strategy is reported here. Analysis of the information collected for utility in performing diagnoses is recommended. In addition, further work is recommended to refine the commonalities into a directly useful computer systems structure.

  17. THE ARCADE 2 INSTRUMENT

    SciTech Connect

    Singal, J.; Fixsen, D. J.; Kogut, A.; Mirel, P.; Wollack, E.; Levin, S.; Seiffert, M.; Limon, M.; Lubin, P.; Villela, T.; Wuensche, C. A.

    2011-04-01

    The second generation Absolute Radiometer for Cosmology, Astrophysics, and Diffuse Emission (ARCADE 2) instrument is a balloon-borne experiment to measure the radiometric temperature of the cosmic microwave background and Galactic and extragalactic emission at six frequencies from 3 to 90 GHz. ARCADE 2 utilizes a double-nulled design where emission from the sky is compared to that from an external cryogenic full-aperture blackbody calibrator by cryogenic switching radiometers containing internal blackbody reference loads. In order to further minimize sources of systematic error, ARCADE 2 features a cold fully open aperture with all radiometrically active components maintained at near 2.7 K without windows or other warm objects, achieved through a novel thermal design. We discuss the design and performance of the ARCADE 2 instrument in its 2005 and 2006 flights.

  18. SABER instrument design update

    NASA Astrophysics Data System (ADS)

    Esplin, Roy W.; Zollinger, Lorin; Batty, J. Clair; Folkman, Steve; Roosta, Mehrdad; Tansock, Joseph J.; Jensen, Mark; Stauder, John; Miller, Jim; Vanek, Michael; Robinson, Don

    1995-09-01

    This paper describes the design of a 10-channel infrared (1.27 to 16.9 micrometers ) radiometer instrument known as SABER (sounding of the atmosphere using broadband emission radiometry) that will measure earth-limb emissions from the TIMED (thermosphere- ionosphere-mesosphere energetics and dynamics) satellite. The instrument telescope, designed to reject stray light from the earth and the atmosphere, is an on-axis Cassegrain design with a clam shell reimager and a one-axis scan mirror. The telescope is cooled below 210 K by a dedicated radiator. The focal plane assembly (consisting of a filter array, a detector array, a Lyot stop, and a window) is cooled to 75 K by a miniature cryogenic refrigerator. The conductive heat load on the refrigerator is minimized by a Kevlar support system that thermally isolates the focal plane assembly from the telescope. Kevlar is also used to thermally isolate the telescope from the spacecraft. Instrument responsivity drifts due to changes in telescope and focal plane temperatures as well as other causes are neutralized by an in-flight calibration system. The detector array consists of discrete HgCdTe, InSb, and InGaAs detectors. Two InGaAs detectors are a new long wavelength type, made by EG&G, that have a long wavelength cutoff of 2.33 micrometers at 77 K.

  19. Mandolin Family Instruments

    NASA Astrophysics Data System (ADS)

    Cohen, David J.; Rossing, Thomas D.

    The mandolin family of instruments consists of plucked chordophones, each having eight strings in four double courses. With the exception of the mandobass, the courses are tuned in intervals of fifths, as are the strings in violin family instruments. The soprano member of the family is the mandolin, tuned G3-D4-A4-E5. The alto member of the family is the mandola, tuned C3-G3-D4-A4. The mandola is usually referred to simply as the mandola in the USA, but is called the tenor mandola in Europe. The tenor member of the family is the octave mandolin, tuned G2-D3-A3-E4. It is referred to as the octave mandolin in the USA, and as the octave mandola in Europe. The baritone member of the family is the mandocello, or mandoloncello, tuned C2-G2-D3-A3. A variant of the mandocello not common in the USA is the five-course liuto moderno, or simply liuto, designed for solo repertoire. Its courses are tuned C2-G2-D3-A3-E4. A mandobass was also made by more than one manufacturer during the early twentieth century, though none are manufactured today. They were fretted instruments with single string courses tuned E1-A1-D2-G2. There are currently a few luthiers making piccolo mandolins, tuned C4-G4-D5-A5.

  20. Embedded instrumentation systems architecture

    NASA Astrophysics Data System (ADS)

    Visnevski, Nikita A.

    2007-04-01

    This paper describes the operational concept of the Embedded Instrumentation Systems Architecture (EISA) that is being developed for Test and Evaluation (T&E) applications. The architecture addresses such future T&E requirements as interoperability, flexibility, and non-intrusiveness. These are the ultimate requirements that support continuous T&E objectives. In this paper, we demonstrate that these objectives can be met by decoupling the Embedded Instrumentation (EI) system into an on-board and an off-board component. An on-board component is responsible for sampling, pre-processing, buffering, and transmitting data to the off-board component. The latter is responsible for aggregating, post-processing, and storing test data as well as providing access to the data via a clearly defined interface including such aspects as security, user authentication and access control. The power of the EISA architecture approach is in its inherent ability to support virtual instrumentation as well as enabling interoperability with such important T&E systems as Integrated Network-Enhanced Telemetry (iNET), Test and Training Enabling Architecture (TENA) and other relevant Department of Defense initiatives.

  1. An ice lithography instrument

    NASA Astrophysics Data System (ADS)

    Han, Anpan; Chervinsky, John; Branton, Daniel; Golovchenko, J. A.

    2011-06-01

    We describe the design of an instrument that can fully implement a new nanopatterning method called ice lithography, where ice is used as the resist. Water vapor is introduced into a scanning electron microscope (SEM) vacuum chamber above a sample cooled down to 110 K. The vapor condenses, covering the sample with an amorphous layer of ice. To form a lift-off mask, ice is removed by the SEM electron beam (e-beam) guided by an e-beam lithography system. Without breaking vacuum, the sample with the ice mask is then transferred into a metal deposition chamber where metals are deposited by sputtering. The cold sample is then unloaded from the vacuum system and immersed in isopropanol at room temperature. As the ice melts, metal deposited on the ice disperses while the metals deposited on the sample where the ice had been removed by the e-beam remains. The instrument combines a high beam-current thermal field emission SEM fitted with an e-beam lithography system, cryogenic systems, and a high vacuum metal deposition system in a design that optimizes ice lithography for high throughput nanodevice fabrication. The nanoscale capability of the instrument is demonstrated with the fabrication of nanoscale metal lines.

  2. Impact dynamics instrumentation

    NASA Astrophysics Data System (ADS)

    McCormck, R. F.

    1986-01-01

    One of the tasks specified in the NASA Langley controlled impact demonstration (CID) work package was to furnish dynamic instrumentation sensors. The types of instrumentation sensors required were accelerometers for aircraft structural loads measurements, seat belt load cells to measure anthropomorphic dummy responses to the aircraft impact, and strain gage bending bridges to measure the aircraft fuselage and wing bending during impact. The objective in the selection of dynamic instrumentation for the CID was to provide 352 of the highest quality transducers and remain within budget allocation. The transducers that were selected for the CID evaluation process were each subjected to rigorous laboratory acceptance tests and to aircraft fuselage section drop tests at the LaRC Impact Dynamics Research Facility. Data compiled from this series of tests showed the selected transducers to be best suited for the CID mission requirement. The transducers installation technique on the airframe proved successful. The transducer quality assurance was guaranteed through rigorous acceptance testing. Data acquired was 97.0%.

  3. Borehole survey instrument

    SciTech Connect

    Sharp, H.E.; Lin, J.W. III; Macha, E.S.; Smither, M.A.

    1984-12-04

    A borehole survey instrument is provided having a meniscus type floating compass member with indicia thereon for indicating azimuth and inclination. A light source is disposed below the indicia for illuminating the indicia upward through the liquid through which the meniscus type floating compass member floats. A lens system is provided for focusing the image of the illuminated compass member upon a film disposed below the compass member. This arrangement permits the centering post for the compass member to be of minimum diameter consistent with rigidity requirements and permits a high angle compass member to indicate angles of inclination approaching ninety degrees. A multiple light bulb light source is utilized and each light bulb is mounted in a manner which permits a single light bulb to illuminate the entire compass member. A hand-held programming and diagnostic unit is provided which may be momentarily electrically mated with the borehole survey tool to input a programmed timed delay and diagnostically test both the condition of the light bulbs utilized as the illumination source and the state of the batteries within the instrument. This hand-held programmable unit eliminates all the mechanical programming switches and permits the instrument to be completely sealed from the pressure, fluids and contaminants normally found in a well bore.

  4. An ice lithography instrument

    PubMed Central

    Han, Anpan; Chervinsky, John; Branton, Daniel; Golovchenko, J. A.

    2011-01-01

    We describe the design of an instrument that can fully implement a new nanopatterning method called ice lithography, where ice is used as the resist. Water vapor is introduced into a scanning electron microscope (SEM) vacuum chamber above a sample cooled down to 110 K. The vapor condenses, covering the sample with an amorphous layer of ice. To form a lift-off mask, ice is removed by the SEM electron beam (e-beam) guided by an e-beam lithography system. Without breaking vacuum, the sample with the ice mask is then transferred into a metal deposition chamber where metals are deposited by sputtering. The cold sample is then unloaded from the vacuum system and immersed in isopropanol at room temperature. As the ice melts, metal deposited on the ice disperses while the metals deposited on the sample where the ice had been removed by the e-beam remains. The instrument combines a high beam-current thermal field emission SEM fitted with an e-beam lithography system, cryogenic systems, and a high vacuum metal deposition system in a design that optimizes ice lithography for high throughput nanodevice fabrication. The nanoscale capability of the instrument is demonstrated with the fabrication of nanoscale metal lines. PMID:21721733

  5. Instrumentation and diagnostics

    SciTech Connect

    Nakaishi, C.V.; Bedick, R.C.

    1990-12-01

    This Technology Status Report describes research and accomplishments for the Instrumentation and Diagnostics (I D) Projects within the Advanced Research and Technology Development (AR TD) Program of the United States Department of Energy (DOE) Office of Fossil Energy (FE). Process understanding and control can be improved through the development of advanced instrumentation and diagnostics. The thrust of the I D Projects is to further develop existing measurement and control techniques for application to advanced coal-based technologies. Project highlights are: an inductively coupled plasma (ICP) instrument has been developed to analyze trace elements in gasification and combustion process streams. An in situ two-color Mie scattering technique with LSS can simultaneously measure the size, velocity, and elemental composition of coal particles during combustion. A high-temperature, fluorescence thermometry technique has accurately measured gas temperatures during field testing in combustion and gasification environments. Expert systems have been developed to improve the control of advanced coal-based processes. Capacitance flowmeters were developed to determine the mass flowrate, solid volume fraction, and particle velocities of coal slurries. 32 refs., 9 figs.

  6. An ice lithography instrument

    SciTech Connect

    Han, Anpan; Chervinsky, John; Branton, Daniel; Golovchenko, J. A.

    2011-06-15

    We describe the design of an instrument that can fully implement a new nanopatterning method called ice lithography, where ice is used as the resist. Water vapor is introduced into a scanning electron microscope (SEM) vacuum chamber above a sample cooled down to 110 K. The vapor condenses, covering the sample with an amorphous layer of ice. To form a lift-off mask, ice is removed by the SEM electron beam (e-beam) guided by an e-beam lithography system. Without breaking vacuum, the sample with the ice mask is then transferred into a metal deposition chamber where metals are deposited by sputtering. The cold sample is then unloaded from the vacuum system and immersed in isopropanol at room temperature. As the ice melts, metal deposited on the ice disperses while the metals deposited on the sample where the ice had been removed by the e-beam remains. The instrument combines a high beam-current thermal field emission SEM fitted with an e-beam lithography system, cryogenic systems, and a high vacuum metal deposition system in a design that optimizes ice lithography for high throughput nanodevice fabrication. The nanoscale capability of the instrument is demonstrated with the fabrication of nanoscale metal lines.

  7. An ice lithography instrument.

    PubMed

    Han, Anpan; Chervinsky, John; Branton, Daniel; Golovchenko, J A

    2011-06-01

    We describe the design of an instrument that can fully implement a new nanopatterning method called ice lithography, where ice is used as the resist. Water vapor is introduced into a scanning electron microscope (SEM) vacuum chamber above a sample cooled down to 110 K. The vapor condenses, covering the sample with an amorphous layer of ice. To form a lift-off mask, ice is removed by the SEM electron beam (e-beam) guided by an e-beam lithography system. Without breaking vacuum, the sample with the ice mask is then transferred into a metal deposition chamber where metals are deposited by sputtering. The cold sample is then unloaded from the vacuum system and immersed in isopropanol at room temperature. As the ice melts, metal deposited on the ice disperses while the metals deposited on the sample where the ice had been removed by the e-beam remains. The instrument combines a high beam-current thermal field emission SEM fitted with an e-beam lithography system, cryogenic systems, and a high vacuum metal deposition system in a design that optimizes ice lithography for high throughput nanodevice fabrication. The nanoscale capability of the instrument is demonstrated with the fabrication of nanoscale metal lines. PMID:21721733

  8. Simulation visualization through dynamic instrumentation

    SciTech Connect

    Bisset, K.R.

    1998-09-01

    The goal of the instrument composition system is to allow a simulation user to dynamically create instruments as a simulation executes. Instruments can include graphical displays, data collectors, and debugging aides. Instruments are made up of small building blocks which can be easily combined into larger, more complex instruments. Through the sue of an Attribute Server (a distributed publication/subscription mechanism), the actors and instruments in a simulation can interact without direct knowledge of each other. Instead, each actor publishes the attributes which it has available. An instrument subscribes to the attributes in which it is interested, and is notified whenever the value of one of these attribute changes. An instrument can also publish attributes for use by other instruments. Since the Attribute Server is distributed, the publisher of an attribute need not execute on the same machine as the subscriber. This allows CPU intensive data visualization to execute on separate machines from the simulation, minimizing the impact on the simulation.

  9. FHR Process Instruments

    SciTech Connect

    Holcomb, David Eugene

    2015-01-01

    Fluoride salt-cooled High temperature Reactors (FHRs) are entering into early phase engineering development. Initial candidate technologies have been identified to measure all of the required process variables. The purpose of this paper is to describe the proposed measurement techniques in sufficient detail to enable assessment of the proposed instrumentation suite and to support development of the component technologies. This paper builds upon the instrumentation chapter of the recently published FHR technology development roadmap. Locating instruments outside of the intense core radiation and high-temperature fluoride salt environment significantly decreases their environmental tolerance requirements. Under operating conditions, FHR primary coolant salt is a transparent, low-vapor-pressure liquid. Consequently, FHRs can employ standoff optical measurements from above the salt pool to assess in-vessel conditions. For example, the core outlet temperature can be measured by observing the fuel s blackbody emission. Similarly, the intensity of the core s Cerenkov glow indicates the fission power level. Short-lived activation of the primary coolant provides another means for standoff measurements of process variables. The primary coolant flow and neutron flux can be measured using gamma spectroscopy along the primary coolant piping. FHR operation entails a number of process measurements. Reactor thermal power and core reactivity are the most significant variables for process control. Thermal power can be determined by measuring the primary coolant mass flow rate and temperature rise across the core. The leading candidate technologies for primary coolant temperature measurement are Au-Pt thermocouples and Johnson noise thermometry. Clamp-on ultrasonic flow measurement, that includes high-temperature tolerant standoffs, is a potential coolant flow measurement technique. Also, the salt redox condition will be monitored as an indicator of its corrosiveness. Both

  10. Topics in Chemical Instrumentation, Cl. Thermoluminescence: Part II. Instrumentation.

    ERIC Educational Resources Information Center

    Manche, Emanuel P.

    1979-01-01

    Presents part two on the use of the detection of thermoluminescence as an analytical tool for the chemistry laboratory and allied science. This part discusses instrumentation used and investigates recent developments in instrumentation for thermoluminescence. (HM)

  11. CARMENES instrument overview

    NASA Astrophysics Data System (ADS)

    Quirrenbach, A.; Amado, P. J.; Caballero, J. A.; Mundt, R.; Reiners, A.; Ribas, I.; Seifert, W.; Abril, M.; Aceituno, J.; Alonso-Floriano, F. J.; Ammler-von Eiff, M.; Antona Jiménez, R.; Anwand-Heerwart, H.; Azzaro, M.; Bauer, F.; Barrado, D.; Becerril, S.; Béjar, V. J. S.; Benítez, D.; Berdiñas, Z. M.; Cárdenas, M. C.; Casal, E.; Claret, A.; Colomé, J.; Cortés-Contreras, M.; Czesla, S.; Doellinger, M.; Dreizler, S.; Feiz, C.; Fernández, M.; Galadí, D.; Gálvez-Ortiz, M. C.; García-Piquer, A.; García-Vargas, M. L.; Garrido, R.; Gesa, L.; Gómez Galera, V.; González Álvarez, E.; González Hernández, J. I.; Grözinger, U.; Guàrdia, J.; Guenther, E. W.; de Guindos, E.; Gutiérrez-Soto, J.; Hagen, H.-J.; Hatzes, A. P.; Hauschildt, P. H.; Helmling, J.; Henning, T.; Hermann, D.; Hernández Castaño, L.; Herrero, E.; Hidalgo, D.; Holgado, G.; Huber, A.; Huber, K. F.; Jeffers, S.; Joergens, V.; de Juan, E.; Kehr, M.; Klein, R.; Kürster, M.; Lamert, A.; Lalitha, S.; Laun, W.; Lemke, U.; Lenzen, R.; López del Fresno, Mauro; López Martí, B.; López-Santiago, J.; Mall, U.; Mandel, H.; Martín, E. L.; Martín-Ruiz, S.; Martínez-Rodríguez, H.; Marvin, C. J.; Mathar, R. J.; Mirabet, E.; Montes, D.; Morales Muñoz, R.; Moya, A.; Naranjo, V.; Ofir, A.; Oreiro, R.; Pallé, E.; Panduro, J.; Passegger, V.-M.; Pérez-Calpena, A.; Pérez Medialdea, D.; Perger, M.; Pluto, M.; Ramón, A.; Rebolo, R.; Redondo, P.; Reffert, S.; Reinhardt, S.; Rhode, P.; Rix, H.-W.; Rodler, F.; Rodríguez, E.; Rodríguez-López, C.; Rodríguez-Pérez, E.; Rohloff, R.-R.; Rosich, A.; Sánchez-Blanco, E.; Sánchez Carrasco, M. A.; Sanz-Forcada, J.; Sarmiento, L. F.; Schäfer, S.; Schiller, J.; Schmidt, C.; Schmitt, J. H. M. M.; Solano, E.; Stahl, O.; Storz, C.; Stürmer, J.; Suárez, J. C.; Ulbrich, R. G.; Veredas, G.; Wagner, K.; Winkler, J.; Zapatero Osorio, M. R.; Zechmeister, M.; Abellán de Paco, F. J.; Anglada-Escudé, G.; del Burgo, C.; Klutsch, A.; Lizon, J. L.; López-Morales, M.; Morales, J. C.; Perryman, M. A. C.; Tulloch, S. M.; Xu, W.

    2014-07-01

    This paper gives an overview of the CARMENES instrument and of the survey that will be carried out with it during the first years of operation. CARMENES (Calar Alto high-Resolution search for M dwarfs with Exoearths with Near-infrared and optical Echelle Spectrographs) is a next-generation radial-velocity instrument under construction for the 3.5m telescope at the Calar Alto Observatory by a consortium of eleven Spanish and German institutions. The scientific goal of the project is conducting a 600-night exoplanet survey targeting ~ 300 M dwarfs with the completed instrument. The CARMENES instrument consists of two separate echelle spectrographs covering the wavelength range from 0.55 to 1.7 μm at a spectral resolution of R = 82,000, fed by fibers from the Cassegrain focus of the telescope. The spectrographs are housed in vacuum tanks providing the temperature-stabilized environments necessary to enable a 1 m/s radial velocity precision employing a simultaneous calibration with an emission-line lamp or with a Fabry-Perot etalon. For mid-M to late-M spectral types, the wavelength range around 1.0 μm (Y band) is the most important wavelength region for radial velocity work. Therefore, the efficiency of CARMENES has been optimized in this range. The CARMENES instrument consists of two spectrographs, one equipped with a 4k x 4k pixel CCD for the range 0.55 - 1.05 μm, and one with two 2k x 2k pixel HgCdTe detectors for the range from 0.95 - 1.7μm. Each spectrograph will be coupled to the 3.5m telescope with two optical fibers, one for the target, and one for calibration light. The front end contains a dichroic beam splitter and an atmospheric dispersion corrector, to feed the light into the fibers leading to the spectrographs. Guiding is performed with a separate camera; on-axis as well as off-axis guiding modes are implemented. Fibers with octagonal cross-section are employed to ensure good stability of the output in the presence of residual guiding errors. The

  12. Instrumentation: Software-Driven Instrumentation: The New Wave.

    ERIC Educational Resources Information Center

    Salit, M. L.; Parsons, M. L.

    1985-01-01

    Software-driven instrumentation makes measurements that demand a computer as an integral part of either control, data acquisition, or data reduction. The structure of such instrumentation, hardware requirements, and software requirements are discussed. Examples of software-driven instrumentation (such as wavelength-modulated continuum source…

  13. Instruments for Water Quality Monitoring

    ERIC Educational Resources Information Center

    Ballinger, Dwight G.

    1972-01-01

    Presents information regarding available instruments for industries and agencies who must monitor numerous aquatic parameters. Charts denote examples of parameters sampled, testing methods, range and accuracy of test methods, cost analysis, and reliability of instruments. (BL)

  14. LBL's Pollution Instrumentation Comparability Program.

    ERIC Educational Resources Information Center

    McLaughlin, R. D.; And Others

    1979-01-01

    Contained are condensed excerpts from the Lawrence Berkeley Laboratory Survey of Instrumentation for Environmental Monitoring. The survey describes instrumentation used to analyze air and water quality, radiation emissions, and biomedical impacts. (BB)

  15. Instrument Synthesis and Analysis Laboratory

    NASA Technical Reports Server (NTRS)

    Wood, H. John

    2004-01-01

    The topics addressed in this viewgraph presentation include information on 1) Historic instruments at Goddard; 2) Integrated Design Capability at Goddard; 3) The Instrument Synthesis and Analysis Laboratory (ISAL).

  16. Precision Instrument and Equipment Repairers.

    ERIC Educational Resources Information Center

    Wyatt, Ian

    2001-01-01

    Explains the job of precision instrument and equipment repairers, who work on cameras, medical equipment, musical instruments, watches and clocks, and industrial measuring devices. Discusses duties, working conditions, employment and earnings, job outlook, and skills and training. (JOW)

  17. ZBLAN Viscosity Instrumentation

    NASA Technical Reports Server (NTRS)

    Kaukler, William

    2001-01-01

    The past year's contribution from Dr. Kaukler's experimental effort consists of these 5 parts: a) Construction and proof-of-concept testing of a novel shearing plate viscometer designed to produce small shear rates and operate at elevated temperatures; b) Preparing nonlinear polymeric materials to serve as standards of nonlinear Theological behavior; c) Measurements and evaluation of above materials for nonlinear rheometric behavior at room temperature using commercial spinning cone and plate viscometers available in the lab; d) Preparing specimens from various forms of pitch for quantitative comparative testing in a Dynamic Mechanical Analyzer, Thermal Mechanical Analyzer; and Archeological Analyzer; e) Arranging to have sets of pitch specimens tested using the various instruments listed above, from different manufacturers, to form a baseline of the viscosity variation with temperature using the different test modes offered by these instruments by compiling the data collected from the various test results. Our focus in this project is the shear thinning behavior of ZBLAN glass over a wide range of temperature. Experimentally, there are no standard techniques to perform such measurements on glasses, particularly at elevated temperatures. Literature reviews to date have shown that shear thinning in certain glasses appears to occur, but no data is available for ZBLAN glass. The best techniques to find shear thinning behavior require the application of very low rates of shear. In addition, because the onset of the thinning behavior occurs at an unknown elevated temperature, the instruments used in this study must provide controlled low rates of shear and do so for temperatures approaching 600 C. In this regard, a novel shearing parallel plate viscometer was designed and a prototype built and tested.

  18. Diamonds for beam instrumentation

    SciTech Connect

    Griesmayer, Erich

    2013-04-19

    Diamond is perhaps the most versatile, efficient and radiation tolerant material available for use in beam detectors with a correspondingly wide range of applications in beam instrumentation. Numerous practical applications have demonstrated and exploited the sensitivity of diamond to charged particles, photons and neutrons. In this paper, a brief description of a generic diamond detector is given and the interaction of the CVD diamond detector material with protons, electrons, photons and neutrons is presented. Latest results of the interaction of sCVD diamond with 14 MeV mono-energetic neutrons are shown.

  19. Instrumental musicians' hazards.

    PubMed

    Hoppmann, R A

    2001-01-01

    In the last two decades, injuries to instrumental musicians have been well documented. Major categories of performance-related injuries include musculoskeletal overuse, nerve entrapment/thoracic outlet syndrome, and focal dystonia. Other areas of concern to instrumentalists include hypermobility, osteoarthritis, fibromyalgia, and hearing loss. This chapter reviews the epidemiology, risk factors, physical exam, treatment, and prevention of common problems of instrumentalists. Emphasis is placed on the team approach of treatment and prevention and the need for close collaboration of the various health professionals, music educators, and performers. Additional resources are presented for those interested in pursuing performing arts medicine in greater detail. PMID:11567922

  20. Biomagnetic instrumentation and measurement

    NASA Technical Reports Server (NTRS)

    Iufer, E. J.

    1978-01-01

    The instruments and techniques of biomagnetic measurement have progressed greatly in the past 15 years and are now of a quality appropriate to clinical applications. The paper reports on recent developments in the design and application of SQUID (Superconducting Quantum Interference Device) magnetometers to biomagnetic measurement. The discussion covers biomagnetic field levels, magnetocardiography, magnetic susceptibility plethysmography, ambient noise and sensor types, principles of operation of a SQUID magnetometer, and laboratory techniques. Of the many promising applications of noninvasive biomagnetic measurement, magnetocardiography is the most advanced and the most likely to find clinical application in the near future.

  1. Instrument Quality Control.

    PubMed

    Jayakody, Chatura; Hull-Ryde, Emily A

    2016-01-01

    Well-defined quality control (QC) processes are used to determine whether a certain procedure or action conforms to a widely accepted standard and/or set of guidelines, and are important components of any laboratory quality assurance program (Popa-Burke et al., J Biomol Screen 14: 1017-1030, 2009). In this chapter, we describe QC procedures useful for monitoring the accuracy and precision of laboratory instrumentation, most notably automated liquid dispensers. Two techniques, gravimetric QC and photometric QC, are highlighted in this chapter. When used together, these simple techniques provide a robust process for evaluating liquid handler accuracy and precision, and critically underpin high-quality research programs. PMID:27316990

  2. Diaphragms for Aeronautic Instruments

    NASA Technical Reports Server (NTRS)

    Hersey, M D

    1924-01-01

    This investigation was carried out at the request of the National Advisory Committee for Aeronautics and comprises an outline of historical developments and theoretical principles, together with a discussion of expedients for making the most effective use of existing diaphragms actuated by the hydrostatic pressure form an essential element of a great variety instruments for aeronautic and other technical purposes. The various physical data needed as a foundation for rational methods of diaphragm design have not, however, been available hitherto except in the most fragmentary form.

  3. Keyboard Emulation For Computerized Instrumentation

    NASA Technical Reports Server (NTRS)

    Wiegand, P. M.; Crouch, S. R.

    1989-01-01

    Keyboard emulator has interface at same level as manual keyboard entry. Since communication and control take place at high intelligence level in instrument, all instrument circuitry fully utilized. Little knowledge of instrument circuitry necessary, since only task interface performs is key closure. All existing logic and error checking still performed by instrument, minimizing workload of laboratory microcomputer. Timing constraints for interface operation minimal at keyboard entry level.

  4. Surface composition mapping radiometer instrument

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The design, development, and fabrication of a three-channel scanning radiometer are discussed. The instrument was flown on Nimbus 5 satellite and measured infrared energy in the 8.3 to 9.3, 10.2 to 11.2, and 0.8 to 1.1 micron spectral regions. The instrument parameters are presented. Theoretical discussions of the instrument subassemblies are provided. Operational details of the mechanical and electrical portions of the instrument are included.

  5. A new innovative instrument for space plasma instrumentation

    NASA Technical Reports Server (NTRS)

    Torbert, Roy B.

    1993-01-01

    The Faraday Ring Ammeter was the subject of this grant for a new innovative instrument for space plasma instrumentation. This report summarizes our progress in this work. Briefly, we have conducted an intensive series of experiments and trials over three years, testing some five configurations of the instrument to measure currents, resulting in two Ph.D. theses, supported by this grant, and two flight configurations of the instrument. The first flight would have been on a NASA-Air Force collaborative sounding rocket, but was not flown because of instrumental difficulties. The second has been successfully integrated on the NASA Auroral Turbulence payload which is to be launched in February, 1994.

  6. Instruments for Water Quality Measurements

    ERIC Educational Resources Information Center

    Phillips, Sidney L.; Mack, Dick A.

    1975-01-01

    This discussion gives a general picture of the instrumentation available or being developed for measuring the four major categories of water pollutants: metals, nutrients, pesticides and oxygen demand. The instruments are classified as follows: manually operated laboratory analyzers, automated laboratory instrumentation, manual field monitors, and…

  7. Spacecraft instrument calibration and stability

    NASA Technical Reports Server (NTRS)

    Gille, J. C.; Feldman, P.; Hudson, R.; Lean, J.; Madden, R.; Mcmaster, L.; Mount, G.; Rottman, G.; Simon, P. C.

    1989-01-01

    The following topics are covered: instrument degradation; the Solar Backscatter Ultraviolet (SBUV) Experiment; the Total Ozone Mapping Spectrometer (TOMS); the Stratospheric Aerosol and Gas Experiment 1 (SAGE-1) and SAGE-2 instruments; the Solar Mesosphere Explorer (SME) UV ozone and near infrared airglow instruments; and the Limb Infrared Monitor of the Stratosphere (LIMS).

  8. Instrument Remote Control via the Astronomical Instrument Markup Language

    NASA Technical Reports Server (NTRS)

    Sall, Ken; Ames, Troy; Warsaw, Craig; Koons, Lisa; Shafer, Richard

    1998-01-01

    The Instrument Remote Control (IRC) project ongoing at NASA's Goddard Space Flight Center's (GSFC) Information Systems Center (ISC) supports NASA's mission by defining an adaptive intranet-based framework that provides robust interactive and distributed control and monitoring of remote instruments. An astronomical IRC architecture that combines the platform-independent processing capabilities of Java with the power of Extensible Markup Language (XML) to express hierarchical data in an equally platform-independent, as well as human readable manner, has been developed. This architecture is implemented using a variety of XML support tools and Application Programming Interfaces (API) written in Java. IRC will enable trusted astronomers from around the world to easily access infrared instruments (e.g., telescopes, cameras, and spectrometers) located in remote, inhospitable environments, such as the South Pole, a high Chilean mountaintop, or an airborne observatory aboard a Boeing 747. Using IRC's frameworks, an astronomer or other scientist can easily define the type of onboard instrument, control the instrument remotely, and return monitoring data all through the intranet. The Astronomical Instrument Markup Language (AIML) is the first implementation of the more general Instrument Markup Language (IML). The key aspects of our approach to instrument description and control applies to many domains, from medical instruments to machine assembly lines. The concepts behind AIML apply equally well to the description and control of instruments in general. IRC enables us to apply our techniques to several instruments, preferably from different observatories.

  9. An Instrumental Innovation

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Think of guitars and you think of rock and country music, or the vigorous rhythms of the gypsy flamenco, or perhaps the classical strumming of a Segovia. About the last thing you would associate with guitars is aerospace technology. Yet there is a connection. A whole family of quality guitars is an outgrowth of helicopter rotor research conducted for the military services and NASA by an aerospace contractor. These musical spinoffs, commercially available and rapidly gaining in popularity, are the Ovation guitar line, manufactured by Ovation Instruments, Inc., Bloomfield, Connecticut. Ovation Instruments is a subsidiary of Kaman Corporation, a diversified company originally formed to develop and build helicopters. A helicopter's rotor system, with thousands of moving parts, is highly susceptible to vibration. For rotor efficiency, vibration must be "dampened," or reduced. Like other helicopter builders, Kaman Corporation spent years of research toward that end. The technology thus developed, together with the availability of staff experts in vibration engineering, sparked an idea in the mind of the company's president and founder, Charles H. Karnan. A guitarist of professional caliber, Kaman reasoned that vibration-dampening technology could be turned around to enhance vibration and thereby produce a guitar with superior sound.

  10. The QUIET Instrument

    NASA Technical Reports Server (NTRS)

    Gaier, T.; Kangaslahti, P.; Lawrence, C. R.; Leitch, E. M.; Wollack, E. J.

    2012-01-01

    The Q/U Imaging ExperimenT (QUIET) is designed to measure polarization in the Cosmic Microwave Background, targeting the imprint of inflationary gravitational waves at large angular scales ( approx 1 deg.) . Between 2008 October and 2010 December, two independent receiver arrays were deployed sequentially on a 1.4 m side-fed Dragonian telescope. The polarimeters which form the focal planes use a highly compact design based on High Electron Mobility Transistors (HEMTs) that provides simultaneous measurements of the Stokes parameters Q, U, and I in a single module. The 17-element Q-band polarimeter array, with a central frequency of 43.1 GHz, has the best sensitivity (69 micro Ks(exp 1/2)) and the lowest instrumental systematic errors ever achieved in this band, contributing to the tensor-to-scalar ratio at r < 0.1. The 84-element W-band polarimeter array has a sensitivity of 87 micro Ks(exp 1/2) at a central frequency of 94.5 GHz. It has the lowest systematic errors to date, contributing at r < 0.01 (QUIET Collaboration 2012) The two arrays together cover multipoles in the range l approximately equals 25-975 . These are the largest HEMT-ba.sed arrays deployed to date. This article describes the design, calibration, performance of, and sources of systematic error for the instrument,

  11. Instrumentation for Submillimeter Polarimetry

    NASA Technical Reports Server (NTRS)

    Dragovan, M.; Novak, G.

    1984-01-01

    During the last two years three instruments were built and operated for detection of polarization in the submillimeter to millimeter wavelength bands. In principle, simply rotating a polarizing grid in front of the detector would be sufficient to determine the state of linear polarization. In practice severe systematic problems are found with this approach. Everything in the light path has potential for inducing polarization. The telescope, apertures in the lightpath, and the Winston light collectors all introduce systematic errors. (The polarization/depolarization induced by these devices is due to diffraction and the finite conductivity of the metals used). Two of the polarimeters are for use on the KAO; the third is for the IRTF on Mauna Kea. The airplane polarimeters, M1 and M2, were specifically designed to minimize the systematic errors. The ground based polarimeter uses our f/35 photometer with an external polarizing grid as the analyzer. With all three instruments the key to success is the data collector and analysis scheme.

  12. The QUIET Instrument

    SciTech Connect

    Bischoff, C.; et al.

    2012-07-01

    The Q/U Imaging ExperimenT (QUIET) is designed to measure polarization in the Cosmic Microwave Background, targeting the imprint of inflationary gravitational waves at large angular scales ({approx}1{sup o}). Between 2008 October and 2010 December, two independent receiver arrays were deployed sequentially on a 1.4m side-fed Dragonian telescope. The polarimeters which form the focal planes use a highly compact design based on High Electron Mobility Transistors (HEMTs) that provides simultaneous measurements of the Stokes parameters Q, U, and I in a single module. The 17-element Q-band polarimeter array, with a central frequency of 43.1 GHz, has the best sensitivity (69 {mu}Ks{sup 1/2}) and the lowest instrumental systematic errors ever achieved in this band, contributing to the tensor-to-scalar ratio at r < 0:1. The 84-element W-band polarimeter array has a sensitivity of 87 {mu}Ks{sup 1/2} at a central frequency of 94.5 GHz. It has the lowest systematic errors to date, contributing at r < 0:01. The two arrays together cover multipoles in the range {ell} {approx} 25 -- 975. These are the largest HEMT-based arrays deployed to date. This article describes the design, calibration, performance of, and sources of systematic error for the instrument.

  13. HETDEX: Overview of the Hobby-Eberly Telescope Dark Energy Experiment and Instrumentation

    NASA Astrophysics Data System (ADS)

    Hill, Gary J.; Gebhardt, K.; Drory, N.; DePoy, D.; Komatsu, E.; Bender, R.; Schneider, D.; Fabricius, M.; Lee, H.; Tuttle, S.; Marshall, J.; Kelz, A.; Roth, M.; Cornell, M.; HETDEX Collaboration

    2012-01-01

    The Hobby-Eberly Telescope Dark Energy Experiment (HETDEX) is a blind spectroscopic survey to map the evolution of dark energy using Lyman-alpha emitting galaxies as tracers. HETDEX comprises a major upgrade of the HET, deployment of the massively replicated integral field spectrograph, VIRUS, and the execution of a multi-year blind spectroscopic survey. VIRUS, consists of 75 IFUs distributed across the 22-arcmin field of the upgraded 9.2-m HET. Each 50x50 sq. arcsec IFU is made up of 448 1.5-arcsec fibers, and feeds a pair of spectrographs with a fixed bandpass of 350-550 nm and resolving power R 700. Each exposure gathers 33,600 spectra. Observing 20 minutes per field, we reach a line flux limit of 3.5e-17 ergs-sec-1-cm-2 and mAB 22. The baseline survey will deliver spectra of 0.8M LAEs in a 9 cubic Gpc volume with 1.9 < z < 3.5, and 1M [OII] emitters with z < 0.48. In addition, the survey will cover 0.4M other galaxies, 0.25M stars, 2000 galaxy clusters, 7000 QSOs with z < 3.5, and 20,000 NVSS radio sources. The main survey area of 42x7 sq. deg. is centered at 13hr, +53deg. Within that 300 sq. deg. region we cover 1/4.5 with fibers; thus 60 sq. deg. of sky have spectra. Initial observations will be conducted from Spring 2013 through Spring 2015. We present an overview of the project, including instrumentation and details of the planned surveys.

  14. XEUS mission and instruments

    NASA Astrophysics Data System (ADS)

    Bavdaz, Marcos; Peacock, Anthony J.; Parmar, Arvind N.; Beijersbergen, Marco W.

    2002-01-01

    The X-ray Evolving Universe Spectroscopy mission (XEUS) is an ambitious project under study by the European Space Agency (ESA), which aims to probe the distant hot universe with comparable sensitivity to NGST and ALMA. The effective optical area and angular resolution required to perform this task is 30 m2 effective area and <5 inch angular resolution respectively at 1 keV. The single Wolter-I X-ray telescope having these characteristics will be equipped with large area semiconductor detectors and high-resolution cryogenic imaging spectrometers with 2 eV resolution at 1 keV. A novel approach to mission design has been developed, placing the detector instruments on one dedicated spacecraft and the optics on another. The International Space Station (ISS) with the best ever-available infrastructure in space will be used to expand the mirror diameter from 4.5 m to 10 m, by using the European Robotic Arm on the ISS. The detector spacecraft (DSC) uses solar-electric propulsion to maintain its position while flying in formation with the mirror spacecraft. The detector instruments are protected from straylight and contamination by sophisticated baffles and filters, and employing the Earth as a shield to make the most sensitive low energy X-ray observations of the heavily red-shifted universe. After completion of an initial observation phase lasting 5 years, the mirror spacecraft will be upgraded (basically expanded to a full 10 m diameter mirror) at the ISS, while the DSC is replaced by a new spacecraft with a new suite of detector instruments optimised to the full area XEUS mirror. An industrial feasibility study was successfully completed and identified no major problem area. Current activities focus on a full system level study and the necessary technology developments. XEUS is likely to become a truly global mission, involving many of the partners that have teamed up to build the ISS. Japan is already a major partner int the study of XEUS, with ISAS having its main

  15. Robotic servicing of EOS instruments

    NASA Technical Reports Server (NTRS)

    Razzaghi, Andrea I.; Juberts, Maris

    1990-01-01

    This paper addresses robotic servicing of the Earth Observing Satellite (EOS) instruments. The goals of implementing a robotic servicing system on EOS would be to maintain the instruments throughout the required mission life and minimize life-cycle costs. To address robot servicing, an initial design concept has been developed which will be applied to a representative EOS instrument. This instrument will be used as a model for determining the most practical level of servicing of its parts, and how to design these parts for robot servicing. Using this representative EOS instrument as a model, a generic design scheme will be developed that can be applied to all EOS instruments. The first task is to determine how to identify which parts must be designed for robot servicing. Next, the requirements imposed on the instruments and the servicing robot when designing for robot serviceability must be examined.

  16. Well surveying instrument sensor

    SciTech Connect

    Poquette, R.S.

    1981-01-20

    A surveying instrument sensor which includes a gimbal supported for rotation within a casing, a torquer coupled to rotate the gimbal with a first two-axis flexure suspended gyro supported on the gimbal with its spin axis perpendicular to the axis of the gimbal and one of its sensitive axes aligned with the axis of the gimbal, a second two-axis flexure suspended gyro disposed on the gimbal with its spin axis alinged with the axis of the gimbal and having two sensitive axes outputs orthogonal thereto. The output of the first gyro is coupled to the torquer to form a gimbal stabilized loop and the outputs and torquing inputs of the second gimbal coupled into rate capture loops with output signals obtained from the rate captured loops permitting fast and accurate surveying of a well pipe.

  17. NEUTRONIC REACTOR CORE INSTRUMENT

    DOEpatents

    Mims, L.S.

    1961-08-22

    A multi-purpose instrument for measuring neutron flux, coolant flow rate, and coolant temperature in a nuclear reactor is described. The device consists essentially of a hollow thimble containing a heat conducting element protruding from the inner wall, the element containing on its innermost end an amount of fissionsble materinl to function as a heat source when subjected to neutron flux irradiation. Thermocouple type temperature sensing means are placed on the heat conducting element adjacent the fissionable material and at a point spaced therefrom, and at a point on the thimble which is in contact with the coolant fluid. The temperature differentials measured between the thermocouples are determinative of the neutron flux, coolant flow, and temperature being measured. The device may be utilized as a probe or may be incorporated in a reactor core. (AE C)

  18. Portable musical instrument amplifier

    DOEpatents

    Christian, David E.

    1990-07-24

    The present invention relates to a musical instrument amplifier which is particularly useful for electric guitars. The amplifier has a rigid body for housing both the electronic system for amplifying and processing signals from the guitar and the system's power supply. An input plug connected to and projecting from the body is electrically coupled to the signal amplifying and processing system. When the plug is inserted into an output jack for an electric guitar, the body is rigidly carried by the guitar, and the guitar is operatively connected to the electrical amplifying and signal processing system without use of a loose interconnection cable. The amplifier is provided with an output jack, into which headphones are plugged to receive amplified signals from the guitar. By eliminating the conventional interconnection cable, the amplifier of the present invention can be used by musicians with increased flexibility and greater freedom of movement.

  19. Instrumentation Working Group Summary

    NASA Technical Reports Server (NTRS)

    Zaller, Michelle; Miake-Lye, Richard

    1999-01-01

    The Instrumentation Working Group compiled a summary of measurement techniques applicable to gas turbine engine aerosol precursors and particulates. An assessment was made of the limits, accuracy, applicability, and technology readiness of the various techniques. Despite advances made in emissions characterization of aircraft engines, uncertainties still exist in the mechanisms by which aerosols and particulates are produced in the near-field engine exhaust. To adequately assess current understanding of the formation of sulfuric acid aerosols in the exhaust plumes of gas turbine engines, measurements are required to determine the degree and importance of sulfur oxidation in the turbine and at the engine exit. Ideally, concentrations of all sulfur species would be acquired, with emphasis on SO2 and SO3. Numerous options exist for extractive and non-extractive measurement of SO2 at the engine exit, most of which are well developed. SO2 measurements should be performed first to place an upper bound on the percentage of SO2 oxidation. If extractive and non-extractive techniques indicate that a large amount of the fuel sulfur is not detected as SO2, then efforts are needed to improve techniques for SO3 measurements. Additional work will be required to account for the fuel sulfur in the engine exhaust. Chemical Ionization Mass Spectrometry (CI-MS) measurements need to be pursued, although a careful assessment needs to be made of the sampling line impact on the extracted sample composition. Efforts should also be placed on implementing non-intrusive techniques and extending their capabilities by maximizing exhaust coverage for line-of-sight measurements, as well as development of 2-D techniques, where feasible. Recommendations were made to continue engine exit and combustor measurements of particulates. Particulate measurements should include particle size distribution, mass fraction, hydration properties, and volatile fraction. However, methods to ensure that unaltered

  20. Instrumented Pipeline Initiative

    SciTech Connect

    Thomas Piro; Michael Ream

    2010-07-31

    This report summarizes technical progress achieved during the cooperative agreement between Concurrent Technologies Corporation (CTC) and U.S. Department of Energy to address the need for a for low-cost monitoring and inspection sensor system as identified in the Department of Energy (DOE) National Gas Infrastructure Research & Development (R&D) Delivery Reliability Program Roadmap.. The Instrumented Pipeline Initiative (IPI) achieved the objective by researching technologies for the monitoring of pipeline delivery integrity, through a ubiquitous network of sensors and controllers to detect and diagnose incipient defects, leaks, and failures. This report is organized by tasks as detailed in the Statement of Project Objectives (SOPO). The sections all state the objective and approach before detailing results of work.

  1. Sentinel-1 Instrument Overview

    NASA Astrophysics Data System (ADS)

    Snoeij, Paul; Torres, Ramon; Geudtner, Dirk; Brown, Michael; Deghaye, Patrick; Navas-Traver, Ignacio; Ostergaard, Allan; Rommen, Bjorn; Floury, Nicolas; Davidson, Malcolm

    2013-03-01

    The forthcoming European Space Agency (ESA) Sentinel-1 (S-1) C-band SAR constellation will provide continuous all-weather day/night global coverage, with six days exact repetition time (near daily coverage over Europe and Canada) and with radar data delivery within 3 to 24 hours. These features open new possibilities for operational maritime services. The Sentinel-1 space segment has been designed and is being built by an industrial consortium with Thales Alenia Space Italia as prime contractor and EADS Astrium GmbH as C-SAR instrument responsible. It is expected that Sentinel-1A be launched in 2013. This paper will provide an overview of the Sentinel-1 system, the status and characteristics of the technical implementation. The key elements of the system supporting the maritime user community will be highlighted.

  2. Instrumentation and radiopharmaceutical validation.

    PubMed

    Zigler, S S

    2009-08-01

    Although the promise of new positron emission tomography (PET) imaging agents is great, the process of bringing these agents to commercialization remains in its infancy. There are no PET products today that have gone through the full clinical and chemistry development process required to gain marketing approval by the US Food and Drug Administration (FDA). The purpose of this paper was to review validation from the perspective of the chemistry, manufacturing and controls (CMC) section of an FDA filing, as well as the validation requirements described in FDA good manufacturing practice (GMP) regulations, guidance documents and general chapters of the US Pharmacopeia (USP). The review includes discussion of validation from development to commercial production of PET radiopharmaceuticals with a special emphasis on equipment and instrumentation used in production and testing. The goal is to stimulate a dialog that leads to the standardization of industry practices and regulatory requirements for validation practices in PET. PMID:19834450

  3. Instrumented Architectural Simulation System

    NASA Technical Reports Server (NTRS)

    Delagi, B. A.; Saraiya, N.; Nishimura, S.; Byrd, G.

    1987-01-01

    Simulation of systems at an architectural level can offer an effective way to study critical design choices if (1) the performance of the simulator is adequate to examine designs executing significant code bodies, not just toy problems or small application fragements, (2) the details of the simulation include the critical details of the design, (3) the view of the design presented by the simulator instrumentation leads to useful insights on the problems with the design, and (4) there is enough flexibility in the simulation system so that the asking of unplanned questions is not suppressed by the weight of the mechanics involved in making changes either in the design or its measurement. A simulation system with these goals is described together with the approach to its implementation. Its application to the study of a particular class of multiprocessor hardware system architectures is illustrated.

  4. LANDSAT instruments characterization

    NASA Technical Reports Server (NTRS)

    Lee, Y. (Principal Investigator)

    1984-01-01

    Work performed for the LANDSAT instrument characterization task in the areas of absolute radiometry, coherent noise analysis, and between-date smoothing is reported. Absolute radiometric calibration for LANDSAT-5 TM under ambient conditions was performed. The TM Radiometric Algorithms and Performance Program (TRAPP) was modified to create optional midscan data files and to match the TM Image Processing System (TIPS) algorithm for pulse determination. Several data reduction programs were developed, including a linear regression and its plotted result. A fast Fourier transformation study was conducted on the resequenced TM data. Subscenes of homogeneous water within scenes over Pensacola, Florida were used for testing the FFT on the resequenced data. Finally, a gain and pulse height stability study of LANDSAT 5 TM spectral bands was performed.

  5. Ideology as instrument.

    PubMed

    Glassman, Michael; Karno, Donna

    2007-12-01

    Comments on the article by J. T. Jost, which argued that the end-of-ideology claims that emerged in the aftermath of World War II were both incorrect and detrimental to the field of political psychology. M. Glassman and D. Karno make three critical points. First, Jost objectified ideology as a grand strategy implemented at the individual level, rather than as an instrument used for a specific purpose in activity. In doing so, he set ideology up as an "object" that guides human behavior rather than as a rational part of human experience. Second, they take issue with the idea that, because somebody acts in a manner that can be categorized as ideological, there actually is such a thing as ideology separate from that event and/or political experience and that psychologists ought to understand the meaning of ideology in order to understand future human activities as outside observers. Third, Jost seems to see this objective ideology as a unidirectional, causal mechanism for activity, a mechanism that assumes individuals act according to ideology, which eclipses the possibility that immediate ideological positions are the residue of purposeful activity. Glassman and Karno suggest that it may be better to take a pluralistic view of ideology in human action. Where ideology does exist, it is as a purposeful instrument--part of a logically based action to meet some ends-in-view--a mixture of immediate goals tied to secondary belief systems (which have been integrated to serve the material purposes of the purveyors of these ideologies). So if we are to understand ideology, we can only understand it through its use in human activity. PMID:18085858

  6. Instrumentation and control systems, equipment location; instrumentation and control building, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Instrumentation and control systems, equipment location; instrumentation and control building, instrumentation room, bays and console plan. Specifications No. Eng-04-353-55-72; drawing no. 60-09-12; sheet 110 of 148; file no. 1321/61. Stamped: Record drawing - as constructed. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Control Center, Test Area 1-115, near Altair & Saturn Boulevards, Boron, Kern County, CA

  7. Virtual instrument simulator for CERES

    NASA Astrophysics Data System (ADS)

    Chapman, John J.

    1997-12-01

    A benchtop virtual instrument simulator for CERES (clouds and the Earth's radiant energy system) has been built at NASA, Langley Research Center in Hampton, Virginia. The CERES instruments will fly on several earth orbiting platforms notably NASDA's tropical rainfall measurement mission (TRMM) and NASA's Earth observing system (EOS) satellites. CERES measures top of the atmosphere radiative fluxes using microprocessor controlled scanning radiometers. The CERES virtual instrument simulator consists of electronic circuitry identical to the flight unit's twin microprocessors and telemetry interface to the supporting spacecraft electronics and two personal computers (PC) connected to the I/O ports that control azimuth and elevation gimbals. Software consists of the unmodified TRW developed flight code and ground support software which serves as the instrument monitor and NASA/TRW developed engineering models of the scanners. The CERES instrument simulator will serve as a testbed for testing of custom instrument commands intended to solve in-flight anomalies of the instruments which could arise during the CERES mission. One of the supporting computers supports the telemetry display which monitors the simulator microprocessors during the development and testing of custom instrument commands. The CERES engineering development software models have been modified to provide a virtual instrument running on a second supporting computer linked in real time to the instrument flight microprocessor control ports. The CERES instrument simulator will be used to verify memory uploads by the CERES flight operations TEAM at NASA. Plots of the virtual scanner models match the actual instrument scan plots. A high speed logic analyzer has been used to track the performance of the flight microprocessor. The concept of using an identical but non-flight qualified microprocessor and electronics ensemble linked to a virtual instrument with identical system software affords a relatively

  8. Virtual Instrument Simulator for CERES

    NASA Technical Reports Server (NTRS)

    Chapman, John J.

    1997-01-01

    A benchtop virtual instrument simulator for CERES (Clouds and the Earth's Radiant Energy System) has been built at NASA, Langley Research Center in Hampton, VA. The CERES instruments will fly on several earth orbiting platforms notably NASDA's Tropical Rainfall Measurement Mission (TRMM) and NASA's Earth Observing System (EOS) satellites. CERES measures top of the atmosphere radiative fluxes using microprocessor controlled scanning radiometers. The CERES Virtual Instrument Simulator consists of electronic circuitry identical to the flight unit's twin microprocessors and telemetry interface to the supporting spacecraft electronics and two personal computers (PC) connected to the I/O ports that control azimuth and elevation gimbals. Software consists of the unmodified TRW developed Flight Code and Ground Support Software which serves as the instrument monitor and NASA/TRW developed engineering models of the scanners. The CERES Instrument Simulator will serve as a testbed for testing of custom instrument commands intended to solve in-flight anomalies of the instruments which could arise during the CERES mission. One of the supporting computers supports the telemetry display which monitors the simulator microprocessors during the development and testing of custom instrument commands. The CERES engineering development software models have been modified to provide a virtual instrument running on a second supporting computer linked in real time to the instrument flight microprocessor control ports. The CERES Instrument Simulator will be used to verify memory uploads by the CERES Flight Operations TEAM at NASA. Plots of the virtual scanner models match the actual instrument scan plots. A high speed logic analyzer has been used to track the performance of the flight microprocessor. The concept of using an identical but non-flight qualified microprocessor and electronics ensemble linked to a virtual instrument with identical system software affords a relatively inexpensive

  9. Pancreatitis Quality of Life Instrument: Development of a new instrument

    PubMed Central

    Bova, Carol; Barton, Bruce; Hartigan, Celia

    2014-01-01

    Objectives: The goal of this project was to develop the first disease-specific instrument for the evaluation of quality of life in chronic pancreatitis. Methods: Focus groups and interview sessions were conducted, with chronic pancreatitis patients, to identify items felt to impact quality of life which were subsequently formatted into a paper-and-pencil instrument. This instrument was used to conduct an online survey by an expert panel of pancreatologists to evaluate its content validity. Finally, the modified instrument was presented to patients during precognitive testing interviews to evaluate its clarity and appropriateness. Results: In total, 10 patients were enrolled in the focus groups and interview sessions where they identified 50 items. Once redundant items were removed, the 40 remaining items were made into a paper-and-pencil instrument referred to as the Pancreatitis Quality of Life Instrument. Through the processes of content validation and precognitive testing, the number of items in the instrument was reduced to 24. Conclusions: This marks the development of the first disease-specific instrument to evaluate quality of life in chronic pancreatitis. It includes unique features not found in generic instruments (economic factors, stigma, and spiritual factors). Although this marks a giant step forward, psychometric evaluation is still needed prior to its clinical use. PMID:26770703

  10. Experimenting with string musical instruments

    NASA Astrophysics Data System (ADS)

    LoPresto, Michael C.

    2012-03-01

    What follows are several investigations involving string musical instruments developed for and used in a Science of Sound & Light course. The experiments make use of a guitar, orchestral string instruments and data collection and graphing software. They are designed to provide students with concrete examples of how mathematical formulae, when used in physics, represent reality that can actually be observed, in this case, the operation of string musical instruments.

  11. Two Radiative/Thermochemical Instruments

    NASA Technical Reports Server (NTRS)

    Tapphorn, Ralph M.; Janoff, Dwight D.; Shelley, Richard M.

    1990-01-01

    Measurements of absorption and emission complement thermal measurements. Two laboratory instruments for research in combustion and pyrolysis equipped for radiative as well as thermal measurements. One instrument essentially differential scanning calorimeter (DSC) modified to detect radiation emitted by flames. Provides means to evaluate limits of flammability of materials exhibiting exothermic reactions in DSC's. Other instrument used to determine pyrolysis properties of specimens exposed to various gases by measurement of infrared absorption spectra of pyrolysis products.

  12. Instrumentation in Frontal Sinus Surgery.

    PubMed

    Tajudeen, Bobby A; Adappa, Nithin D

    2016-08-01

    Frontal recess dissection proposes many challenges to the surgeon. These challenges stem from its highly variable nature, small caliber, difficult visualization, and proximity to vital structures such as the skull base and orbit. As such, delicate mucosal-sparing dissection of the frontal recess with proper instrumentation is paramount to minimize scar formation and ensure patency. Here, the article explores key instrumentation in frontal recess surgery with an emphasis on hand instruments and adjunctive technologies. PMID:27329980

  13. Radiological instrument. Patent Application

    SciTech Connect

    Kronenberg, S.; McLaughlin, W.L.; Siebentritt, C.R.

    1985-10-10

    This patent application discloses a radiological measuring instrument including an angularly variable radiation-sensitive structure comprised of two blocks of material having a different index of refraction with one of the materials comprising a radiochromic substance whose refractive index changes through anomolous dispersion as a result of being exposed to radiation. The ratio of the two indices of refraction is selected to be close to unity, with the radiation-sensitive structure being pivotally adjusted so that light is directed into one end of the block comprising the material having the greater index of refraction. This element, moreover, is selected to be clear and transparent with the incident angle being close to the critical angle where total reflection of all incident light occurs. A portion of the incident light is furthermore projected through the clear transparent block without reflection, with the two beams emerging from the other end of the block, where they are detected. Exposure to radiation changes the index of refraction of the radiochromic block and accordingly the reflected energy emerging therefrom. Calibrated readjustment of the angle of incidence provides a measure of the sensed radiation.

  14. Instrumentation Working Group Summary

    NASA Technical Reports Server (NTRS)

    Zaller, Michelle; Miake-Lye, Richard

    1999-01-01

    The Instrumentation Working Group compiled a summary of measurement techniques applicable to gas turbine engine aerosol precursors and particulates. An assessment was made of the limits, accuracy, applicability, and technology readiness of the various techniques. Despite advances made in emissions characterization of aircraft engines, uncertainties still exist in the mechanisms by which aerosols and particulates are produced in the near-field engine exhaust. To adequately assess current understanding of the formation of sulfuric acid aerosols in the exhaust plumes of gas turbine engines, measurements are required to determine the degree and importance of sulfur oxidation in the turbine and at the engine exit. Ideally, concentrations of all sulfur species would be acquired, with emphasis on SO2 and SO3. Numerous options exist for extractive and non-extractive measurement of SO2 at the engine exit, most of which are well developed. SO2 measurements should be performed first to place an upper bound on the percentage of SO2 oxidation. If extractive and non-extractive techniques indicate that a large amount of the fuel sulfur is not detected as SO2, then efforts are needed to improve techniques for SO3 measurements. Additional work will be required to account for the fuel sulfur in the engine exhaust. Chemical Ionization Mass Spectrometry (CI-MS) measurements need to be pursued, although a careful assessment needs to be made of the sampling line impact on the extracted sample composition. Efforts should also be placed on implementing non-intrusive techniques and extending their capabilities by maximizing exhaust coverage for line-of-sight measurements, as well as development of 2-D techniques, where feasible. Recommendations were made to continue engine exit and combustor measurements of particulates. Particulate measurements should include particle size distribution, mass fraction, hydration properties, and volatile fraction. However, methods to ensure that unaltered

  15. Halo vest instrumentation

    NASA Astrophysics Data System (ADS)

    Huston, Dryver R.; Krag, Martin

    1996-05-01

    The halo vest is a head and neck immobilization system that is often used on patients that are recovering from cervical trauma or surgery. The halo vest system consists of a rigid halo that is firmly attached to the skull, an upright support structure for stabilization and immobilization, and a torso-enveloping vest. The main purpose of this study was to measure the forces that are carried by the halo-vest structure as the subject undergoes various activities of daily living and external loading for different vest designs. A tethered strain gage load cell based instrumentation system was used to take these load measurements on ten different subjects. Three different halo-vest systems were evaluated. The primary difference between the vests was the amount of torso coverage and the use of shoulder straps. The loads were measured, analyzed and used to compare the vests and to create a model of halo-vest-neck mechanics. Future applications of this technology to standalone data logging, pin-load measuring and biofeedback applications are discussed.

  16. The Clementine instrument complement

    NASA Technical Reports Server (NTRS)

    Lucey, Paul G.

    1993-01-01

    The recent successes of the Galileo solid-state imaging (SSI) experiment at the Moon and Gaspra show the utility of multispectral imaging of planetary objects. 'Clementine' is the planetary community's 'code name' for the SDIO (Space Defense Initiative Organization), mission to the Moon and the asteroid Geographos. This mission is designed as a long term stressing test on sensors and space systems developed for SDIO. In the course of this test Clementine will obtain science data using a varied and powerful array of remote sensing instruments which were developed by or for Lawrence Livermore National Laboratory in Livermore, California. Clementine carries five cameras, one for navigation and four for science experiments. In addition, a laser ranger is included which will serve as a laser altimeter. The Clementine cameras cover a wider range of spatial resolutions and wavelength range than did Galileo and are almost ideally suited to mapping of mafic rock types as are present on the Moon and expected at Geographos. Calibration of the cameras will occur at the sensor calibration laboratory at LLNL. In flight calibrations, using standard stars and other standards should improve the stated accuracies. Signal-to-noise ratios (SNRs) include the following noise sources: shot noise, calibration error, digitization noise, readout noise, and frame transfer noise (where applicable). The achieved SNRs are a balance between detector saturation and acceptable image smear. The 'worst' case uses the longest possible integration times.

  17. The tissue diagnostic instrument

    PubMed Central

    Hansma, Paul; Yu, Hongmei; Schultz, David; Rodriguez, Azucena; Yurtsev, Eugene A.; Orr, Jessica; Tang, Simon; Miller, Jon; Wallace, Joseph; Zok, Frank; Li, Cheng; Souza, Richard; Proctor, Alexander; Brimer, Davis; Nogues-Solan, Xavier; Mellbovsky, Leonardo; Peña, M. Jesus; Diez-Ferrer, Oriol; Mathews, Phillip; Randall, Connor; Kuo, Alfred; Chen, Carol; Peters, Mathilde; Kohn, David; Buckley, Jenni; Li, Xiaojuan; Pruitt, Lisa; Diez-Perez, Adolfo; Alliston, Tamara; Weaver, Valerie; Lotz, Jeffrey

    2009-01-01

    Tissue mechanical properties reflect extracellular matrix composition and organization, and as such, their changes can be a signature of disease. Examples of such diseases include intervertebral disk degeneration, cancer, atherosclerosis, osteoarthritis, osteoporosis, and tooth decay. Here we introduce the tissue diagnostic instrument (TDI), a device designed to probe the mechanical properties of normal and diseased soft and hard tissues not only in the laboratory but also in patients. The TDI can distinguish between the nucleus and the annulus of spinal disks, between young and degenerated cartilage, and between normal and cancerous mammary glands. It can quantify the elastic modulus and hardness of the wet dentin left in a cavity after excavation. It can perform an indentation test of bone tissue, quantifying the indentation depth increase and other mechanical parameters. With local anesthesia and disposable, sterile, probe assemblies, there has been neither pain nor complications in tests on patients. We anticipate that this unique device will facilitate research on many tissue systems in living organisms, including plants, leading to new insights into disease mechanisms and methods for their early detection. PMID:19485522

  18. Detectors for Tomorrow's Instruments

    NASA Technical Reports Server (NTRS)

    Moseley, Harvey

    2009-01-01

    Cryogenically cooled superconducting detectors have become essential tools for a wide range of measurement applications, ranging from quantum limited heterodyne detection in the millimeter range to direct searches for dark matter with superconducting phonon detectors operating at 20 mK. Superconducting detectors have several fundamental and practical advantages which have resulted in their rapid adoption by experimenters. Their excellent performance arises in part from reductions in noise resulting from their low operating temperatures, but unique superconducting properties provide a wide range of mechanisms for detection. For example, the steep dependence of resistance with temperature on the superconductor/normal transition provides a sensitive thermometer for calorimetric and bolometric applications. Parametric changes in the properties of superconducting resonators provides a mechanism for high sensitivity detection of submillimeter photons. From a practical point of view, the use of superconducting detectors has grown rapidly because many of these devices couple well to SQUID amplifiers, which are easily integrated with the detectors. These SQUID-based amplifiers and multiplexers have matured with the detectors; they are convenient to use, and have excellent noise performance. The first generation of fully integrated large scale superconducting detection systems are now being deployed. I will discuss the prospects for a new generation of instruments designed to take full advantage of the revolution in detector technology.

  19. Optical distance measuring instrument

    NASA Technical Reports Server (NTRS)

    Abshire, J. B. (Inventor)

    1986-01-01

    An optical instrument, such as a stability monitor or a target range finder, uses an unstabilized laser to project a composite optical signal of coherent light having two naturally occurring longitudinal mode components. A beamsplitter divides the signal into a reference beam which is directed toward one photodetector and a transmitted beam which illuminates and is reflected from a distant target onto a second photodetector optically isolated from the first photodetector. Both photodetectors are operated on the square law principle to provide electrical signals modulated at a frequency equal to the separation between the frequencies of the two longitudinal mode components of the optical signal projected by the laser. Slight movement of the target may be detected and measured by electrically monitoring the phase difference between the two signals provided by the photodetectors and the range of the target measured with the aid of a microprocessor by changing the separation between the longitudinal modes by shifting the length of the resonator cavity in an iterative series of increments.

  20. The tissue diagnostic instrument

    NASA Astrophysics Data System (ADS)

    Hansma, Paul; Yu, Hongmei; Schultz, David; Rodriguez, Azucena; Yurtsev, Eugene A.; Orr, Jessica; Tang, Simon; Miller, Jon; Wallace, Joseph; Zok, Frank; Li, Cheng; Souza, Richard; Proctor, Alexander; Brimer, Davis; Nogues-Solan, Xavier; Mellbovsky, Leonardo; Peña, M. Jesus; Diez-Ferrer, Oriol; Mathews, Phillip; Randall, Connor; Kuo, Alfred; Chen, Carol; Peters, Mathilde; Kohn, David; Buckley, Jenni; Li, Xiaojuan; Pruitt, Lisa; Diez-Perez, Adolfo; Alliston, Tamara; Weaver, Valerie; Lotz, Jeffrey

    2009-05-01

    Tissue mechanical properties reflect extracellular matrix composition and organization, and as such, their changes can be a signature of disease. Examples of such diseases include intervertebral disk degeneration, cancer, atherosclerosis, osteoarthritis, osteoporosis, and tooth decay. Here we introduce the tissue diagnostic instrument (TDI), a device designed to probe the mechanical properties of normal and diseased soft and hard tissues not only in the laboratory but also in patients. The TDI can distinguish between the nucleus and the annulus of spinal disks, between young and degenerated cartilage, and between normal and cancerous mammary glands. It can quantify the elastic modulus and hardness of the wet dentin left in a cavity after excavation. It can perform an indentation test of bone tissue, quantifying the indentation depth increase and other mechanical parameters. With local anesthesia and disposable, sterile, probe assemblies, there has been neither pain nor complications in tests on patients. We anticipate that this unique device will facilitate research on many tissue systems in living organisms, including plants, leading to new insights into disease mechanisms and methods for their early detection.

  1. Ultrasonics and space instrumentation

    NASA Technical Reports Server (NTRS)

    1987-01-01

    The design topic selected was an outgrowth of the experimental design work done in the Fluid Behavior in Space experiment, which relies on the measurement of minute changes of the pressure and temperature to obtain reasonably accurate volume determinations. An alternative method of volume determination is the use of ultrasonic imaging. An ultrasonic wave system is generated by wall mounted transducer arrays. The interior liquid configuration causes reflection and refraction of the pattern so that analysis of the received wave system provides a description of the configuration and hence volume. Both continuous and chirp probe beams were used in a laboratory experiment simulating a surface wetting propellant. The hardware included a simulated tank with gaseous voids, transmitting and receiving transducers, transmitters, receivers, computer interface, and computer. Analysis software was developed for image generation and interpretation of results. Space instrumentation was pursued in support of a number of experiments under development for GAS flights. The program included thirty undergraduate students pursuing major qualifying project work under the guidance of eight faculty supported by a teaching assistant. Both mechanical and electrical engineering students designed and built several microprocessor systems to measure parameters such as temperature, acceleration, pressure, velocity, and circulation in order to determine combustion products, vortex formation, gas entrainment, EMR emissions from thunderstorms, and milli-g-accelerations due to crew motions.

  2. Instrumentation advances for transonic testing

    NASA Technical Reports Server (NTRS)

    Bobbitt, Percy J.

    1989-01-01

    New and improved instrumentation, like new and improved wind tunnels, provide capabilities which stimulate innovative research and discovery. During the past few years there have been a number of instrumentation developments which have aided and abetted the acquisition of more accurate aerodynamic data and have led to new physical insights as well. Some of these advances are reviewed, particularly in the area of thin film gages, hot wire anemometry, and laser instrumentation. A description is given of the instruments and/or techniques and some sample results are shown.

  3. Guideline implementation: surgical instrument cleaning.

    PubMed

    Cowperthwaite, Liz; Holm, Rebecca L

    2015-05-01

    Cleaning, decontaminating, and handling instructions for instruments vary widely based on the type of instrument and the manufacturer. Processing instruments in accordance with the manufacturer's instructions can help prevent damage and keep devices in good working order. Most importantly, proper cleaning and disinfection may prevent transmission of pathogenic organisms from a contaminated device to a patient or health care worker. The updated AORN "Guideline for cleaning and care of surgical instruments" provides guidance on cleaning, decontaminating, transporting, inspecting, and storing instruments. This article focuses on key points of the guideline to help perioperative personnel implement appropriate instrument care protocols in their practice settings. The key points address timely cleaning and decontamination of instruments after use; appropriate heating, ventilation, and air conditioning parameters for the decontamination area; processing of ophthalmic instruments and laryngoscopes; and precautions to take with instruments used in cases of suspected prion disease. Perioperative RNs should review the complete guideline for additional information and for guidance when writing and updating policies and procedures. PMID:25946180

  4. ({sup 3}He,t) reaction on the double {beta} decay nucleus {sup 48}Ca and the importance of nuclear matrix elements

    SciTech Connect

    Grewe, E.-W.; Frekers, D.; Rakers, S.; Baeumer, C.; Dohmann, H.; Thies, J.; Adachi, T.; Fujita, Y.; Shimbara, Y.; Botha, N. T.; Fujita, H.; Hatanaka, K.; Nakanishi, K.; Sakemi, Y.; Shimizu, Y.; Tameshige, Y.; Tamii, A.; Negret, A.; Popescu, L.; Neveling, R.

    2007-11-15

    High-resolution ({sup 3}He,t) measurements on the double {beta}-decay ({beta}{beta}) nucleus {sup 48}Ca have been performed at RCNP (Osaka, Japan) to determine Gamow-Teller (GT{sup -}) transitions to the nucleus {sup 48}Sc, which represents the intermediate nucleus in the second-order perturbative description of the {beta}{beta} decay. At a bombarding energy of E{sub {sup 3}He}=420 MeV an excitation energy resolution of 40 keV was achieved. The measurements were performed at two angle positions of the Grand Raiden Spectrometer (GRS): 0 deg. and 2.5 deg. The results of both settings were combined to achieve angular distributions, by which the character of single transitions could be determined. To characterize the different multipoles, theoretical angular distributions for states with J{sup {pi}}=1{sup +},2{sup +},2{sup -}, and 3{sup +} were calculated using the distorted-wave Born approximation (DWBA) Code DW81. The GT{sup -} strength was extracted up to E{sub x}=7 MeV and combined with corresponding GT{sup +} strength deduced from the {sup 48}Ti(d,{sup 2}He){sup 48}Sc data to calculate the low-energy part of the {beta}{beta}-decay matrix element for the {sup 48}Ca 2{nu}{beta}{beta} decay. We show that after applying trivial momentum corrections to the ({sup 3}He,t) spectrum, the two reaction probes (p,n) and ({sup 3}He,t) reveal a spectral response to an impressively high degree of similarity in the region of low momentum transfer.

  5. Interstellar Dust Instrumentation

    NASA Astrophysics Data System (ADS)

    Sternovsky, Zoltan; Gruen, E.; Horanyi, M.; Drake, K.; Collette, A.; Kempf, S.; Srama, R.; Postberg, F.; Krueger, H.; Auer, S.

    2010-10-01

    Interstellar grains traversing the inner planetary system have been identified by the Ulysses dust detector. Space dust detectors on other missions confirmed this finding. Analysis of the Stardust collectors is under way to search for and analyze such exotic grains. Interstellar dust particles can be detected and analyzed in the near-Earth space environment. New instrumentation has been developed to determine the origin of dust particles and their elemental composition. A Dust Telescope is a combination of a Dust Trajectory Sensor (DTS, Rev. Sci. Instrum. 79, 084501, 2008) together with a high mass resolution mass analyzer for the chemical composition of dust particles in space. Dust particles' trajectories are determined by the measurement of induced electric signals when a charged grain flies through a position sensitive electrode system. A modern DTS can measure dust particles as small as 0.2 micron in radius and dust speeds up to 100 km/s. Large area chemical analyzers of 0.1 m2 sensitive area have been tested at a dust accelerator and it was demonstrated that they have sufficient mass resolution to resolve ions with atomic mass number up to >100 (Earth, Moon and Planets, DOI: 10.1007/s11038-005-9040-z, 2005; Rev. Sci. Instrum. 78, 014501, 2007). The advanced Dust Telescope is capable of identifying interstellar and interplanetary grains, and measuring their mass, velocity vector, charge, elemental and isotopic compositions. An Active Dust Collector combines a DTS with an aerogel or other dust collector materials, e.g. like the ones used on the Stardust mission. The combination of a DTS with a dust collector provides not only individual trajectories of the collected particles but also their impact time and position on the collector which proves essential in finding collected sub-micron sized grains on the collector.

  6. MISR Instrument Data Visualization

    NASA Technical Reports Server (NTRS)

    Nelson, David; Garay, Michael; Diner, David; Thompson, Charles; Hall, Jeffrey; Rheingans, Brian; Mazzoni, Dominic

    2008-01-01

    The MISR Interactive eXplorer (MINX) software functions both as a general-purpose tool to visualize Multiangle Imaging SpectroRadiometer (MISR) instrument data, and as a specialized tool to analyze properties of smoke, dust, and volcanic plumes. It includes high-level options to create map views of MISR orbit locations; scrollable, single-camera RGB (red-greenblue) images of MISR level 1B2 (L1B2) radiance data; and animations of the nine MISR camera images that provide a 3D perspective of the scenes that MISR has acquired. NASA Tech Briefs, September 2008 55 The plume height capability provides an accurate estimate of the injection height of plumes that is needed by air quality and climate modelers. MISR provides global high-quality stereo height information, and this program uses that information to perform detailed height retrievals of aerosol plumes. Users can interactively digitize smoke, dust, or volcanic plumes and automatically retrieve heights and winds, and can also archive MISR albedos and aerosol properties, as well as fire power and brightness temperatures associated with smoke plumes derived from Moderate Resolution Imaging Spectroradiometer (MODIS) data. Some of the specialized options in MINX enable the user to do other tasks. Users can display plots of top-of-atmosphere bidirectional reflectance factors (BRFs) versus camera-angle for selected pixels. Images and animations can be saved to disk in various formats. Also, users can apply a geometric registration correction to warp camera images when the standard processing correction is inadequate. It is possible to difference the images of two MISR orbits that share a path (identical ground track), as well as to construct pseudo-color images by assigning different combinations of MISR channels (angle or spectral band) to the RGB display channels. This software is an interactive application written in IDL and compiled into an IDL Virtual Machine (VM) ".sav" file.

  7. Technician Program Uses Advanced Instruments.

    ERIC Educational Resources Information Center

    Stinson, Stephen

    1981-01-01

    Describes various aspects of a newly-developed computer-assisted drafting/computer-assisted manufacture (CAD/CAM) facility in the chemical engineering technology department at Broome Community College, Binghamton, New York. Stresses the use of new instruments such as microcomputers and microprocessor-equipped instruments. (CS)

  8. Rating Scale Instruments and Measurement

    ERIC Educational Resources Information Center

    Cavanagh, Robert F.; Romanoski, Joseph T.

    2006-01-01

    The article examines theoretical issues associated with measurement in the human sciences and ensuring data from rating scale instruments are measures. An argument is made that using raw scores from rating scale instruments for subsequent arithmetic operations and applying linear statistics is less preferable than using measures. These theoretical…

  9. Associations in Human Instrumental Conditioning

    ERIC Educational Resources Information Center

    Gamez, A. Matias; Rosas, Juan M.

    2007-01-01

    Four experiments were conducted to study the contents of human instrumental conditioning. Experiment 1 found positive transfer between a discriminative stimulus (S[superscript D] and an instrumental response (R) that shared the outcome (O) with the response that was originally trained with the S[superscript D], showing the formation of an…

  10. Zach's instruments and their characteristics

    NASA Astrophysics Data System (ADS)

    Wolfschmidt, Gudrun

    The astronomically interested Duke Ernst II von Sachsen-Gotha-Altenburg (1745-1804) hired Baron Franz Xaver von Zach (1754-1832) as court astronomer in 1786. Immediatedly Zach started to make plans for instrumentation for a new observatory. But first they travelled with their instruments (a 2-foot Ramsden transit instrument, the Sisson quadrant, three Hadley sextants, two achromatic refractors and chronometers) to southern France. In Hyàres a tower of the wall around the town was converted into an observatory in 1787. For the building of the new observatory Zach had chosen a place outside of Gotha on the top of the Seeberg. The three main instruments were an 8-foot transit instrument made by Ramsden, a northern and southern mural quadrant made by Sisson and a zenith sector made by Cary, in addition an 8-foot circle made by Ramsden. By analysing the whole instrumentation of Gotha observatory, we can see a change around 1800 in the kind of instruments, from quadrants and sextants to the full circles and from the transit instrument to the meridian circle. The decline of the Gotha observatory started with the early death of the Duke in 1804 and the subsequent departure of Zach in 1806.

  11. Introduction to Instrumentation. Teacher Edition.

    ERIC Educational Resources Information Center

    Brown, A. O., III

    This module contains instructional materials on instrumentation to help teachers train students in the job skills they will need as beginning instrumentation technicians. The module addresses the nature of accessing, measuring, and controlling phenomena such as level, flow, pressure, and temperature. Students are introduced to the devices and…

  12. Experimenting with String Musical Instruments

    ERIC Educational Resources Information Center

    LoPresto, Michael C.

    2012-01-01

    What follows are several investigations involving string musical instruments developed for and used in a "Science of Sound & Light" course. The experiments make use of a guitar, orchestral string instruments and data collection and graphing software. They are designed to provide students with concrete examples of how mathematical formulae, when…

  13. Instrument Remote Control Application Framework

    NASA Technical Reports Server (NTRS)

    Ames, Troy; Hostetter, Carl F.

    2006-01-01

    The Instrument Remote Control (IRC) architecture is a flexible, platform-independent application framework that is well suited for the control and monitoring of remote devices and sensors. IRC enables significant savings in development costs by utilizing extensible Markup Language (XML) descriptions to configure the framework for a specific application. The Instrument Markup Language (IML) is used to describe the commands used by an instrument, the data streams produced, the rules for formatting commands and parsing the data, and the method of communication. Often no custom code is needed to communicate with a new instrument or device. An IRC instance can advertise and publish a description about a device or subscribe to another device's description on a network. This simple capability of dynamically publishing and subscribing to interfaces enables a very flexible, self-adapting architecture for monitoring and control of complex instruments in diverse environments.

  14. Cervical Spine Instrumentation in Children.

    PubMed

    Hedequist, Daniel J; Emans, John B

    2016-06-01

    Instrumentation of the cervical spine enhances stability and improves arthrodesis rates in children undergoing surgery for deformity or instability. Various morphologic and clinical studies have been conducted in children, confirming the feasibility of anterior or posterior instrumentation of the cervical spine with modern implants. Knowledge of the relevant spine anatomy and preoperative imaging studies can aid the clinician in understanding the pitfalls of instrumentation for each patient. Preoperative planning, intraoperative positioning, and adherence to strict surgical techniques are required given the small size of children. Instrumentation options include anterior plating, occipital plating, and a variety of posterior screw techniques. Complications related to screw malposition include injury to the vertebral artery, neurologic injury, and instrumentation failure. PMID:27097300

  15. Instrument Concept for the Proposed DESDynI SAR instrument

    NASA Technical Reports Server (NTRS)

    Perkovic-Martin, Dragana; Hoffman, James P.; Veilleux, Louise

    2012-01-01

    The proposed DESDynI (Solid Earth Deformation, Ecosystems Structure and Dynamics of Ice) SAR (synthetic aperture radar) Instrument would expand the trade-space of radar instrument concepts and push the boundaries of high-level integration of digital and RF subsystems in order to achieve very precise assessments of system's behavior; DESDynI mission concept would provide continuous science measurements that would greatly enhance understanding of geophysical and anthropological effects in three science disciplines; Trades in instrument architecture implementations and partnership discussions are producing a set of options for science community and NASA to evaluate and consider implementing late in the decade.

  16. Instrumental variables and Mendelian randomization with invalid instruments

    NASA Astrophysics Data System (ADS)

    Kang, Hyunseung

    Instrumental variables (IV) methods have been widely used to determine the causal effect of a treatment, exposure, policy, or an intervention on an outcome of interest. The IV method relies on having a valid instrument, a variable that is (A1) associated with the exposure, (A2) has no direct effect on the outcome, and (A3) is unrelated to the unmeasured confounders associated with the exposure and the outcome. However, in practice, finding a valid instrument, especially those that satisfy (A2) and (A3), can be challenging. For example, in Mendelian randomization studies where genetic markers are used as instruments, complete knowledge about instruments' validity is equivalent to complete knowledge about the involved genes' functions. The dissertation explores the theory, methods, and application of IV methods when invalid instruments are present. First, when we have multiple candidate instruments, we establish a theoretical bound whereby causal effects are only identified as long as less than 50% of instruments are invalid, without knowing which of the instruments are invalid. We also propose a fast penalized method, called sisVIVE, to estimate the causal effect. We find that sisVIVE outperforms traditional IV methods when invalid instruments are present both in simulation studies as well as in real data analysis. Second, we propose a robust confidence interval under the multiple invalid IV setting. This work is an extension of our work on sisVIVE. However, unlike sisVIVE which is robust to violations of (A2) and (A3), our confidence interval procedure provides honest coverage even if all three assumptions, (A1)-(A3), are violated. Third, we study the single IV setting where the one IV we have may actually be invalid. We propose a nonparametric IV estimation method based on full matching, a technique popular in causal inference for observational data, that leverages observed covariates to make the instrument more valid. We propose an estimator along with

  17. Solid motor diagnostic instrumentation. [design of self-contained instrumentation

    NASA Technical Reports Server (NTRS)

    Nakamura, Y.; Arens, W. E.; Wuest, W. S.

    1973-01-01

    A review of typical surveillance and monitoring practices followed during the flight phases of representative solid-propellant upper stages and apogee motors was conducted to evaluate the need for improved flight diagnostic instrumentation on future spacecraft. The capabilities of the flight instrumentation package were limited to the detection of whether or not the solid motor was the cause of failure and to the identification of probable primary failure modes. Conceptual designs of self-contained flight instrumentation packages capable of meeting these reqirements were generated and their performance, typical cost, and unit characteristics determined. Comparisons of a continuous real time and a thresholded hybrid design were made on the basis of performance, mass, power, cost, and expected life. The results of this analysis substantiated the feasibility of a self-contained independent flight instrumentation module as well as the existence of performance margins by which to exploit growth option applications.

  18. GEO Sounding Using Microwave Instruments

    NASA Technical Reports Server (NTRS)

    Shiue, James; Krimchansky, Sergey; Susskind, Joel; Krimchansky, Alexander; Chu, Donald; Davis, Martin

    2004-01-01

    There are several microwave instruments in low Earth orbit (LEO) that are used for atmospheric temperature and humidity sounding in conjunction with companion IR sounders as well as by themselves. These instruments have achieved a certain degree of maturity and undergoing a redesign to minimize their size, mass, and power from the previous generation instruments. An example of these instruments is the AMSU-A series, now flying on POES and AQUA spacecraft with the IR sounders HIRS and AIRS. These older microwave instruments are going to be replaced by the ATMS instruments that will fly on NPP and NPOESS satellites with the CrIS sounder. A number of techniques learned from the ATMS project in instrument hardware design and data processing are directly applicable to a similar microwave sounder on a geosynchronous platform. These techniques can significantly simplify the design of a Geostationary orbit (GEO) microwave instrument, avoiding costly development and minimizing the risk of not being able to meet the scientific requirements. In fact, some of the 'enabling' technology, such as the use of MMIC microwave components (which is the basis for the ATMS' much reduced volume) can be directly applied to a GEO sounder. The benefits of microwave sounders are well known; for example, they penetrate non-precipitating cloud cover and allow for use of colocated IR observations in up to 80% cloud cover. The key advantages of a microwave instrument in GEO will be the ability to provide high temporal resolution as well as uniform spatial resolution and extend the utility of a colocated advanced IR sounder to cases in which partial cloud cover exists. A footprint of the order of 100 km by 100 km resolution with hemispherical coverage within one hour can be easily achieved for sounding channels in the 50 to 59 GHz range. A GEO microwave sounder will also allow mesoscale sampling of select regions.

  19. Validating GOES Instrument Thermal Deformations

    NASA Technical Reports Server (NTRS)

    Harter, Peter; Ghaffarian, Benny; Ng, Ray; Pugh, Brett; Wilkin, Paul; Sayal, Chetan; Chu, Don

    2001-01-01

    Comparison of the Geostationary Operational Environmental Satellite (GOES) instrument thermal model predictions with on-orbit data shows that the models capture the observed temperature and misalignment trends. Lack of precise knowledge as to spacecraft pointing precludes such comparison with instrument pointing predictions. Based on the models, thermally induced instrument attitude variation will dominate GOES N-Q Image Motion Compensation (IMC). Errors due to day-to-day changes in the attitude profiles are predicted to be under 10 microradians except for rapid scans where disturbances may reach 30 microradians.

  20. Adjustable extender for instrument module

    DOEpatents

    Sevec, J.B.; Stein, A.D.

    1975-11-01

    A blank extender module used to mount an instrument module in front of its console for repair or test purposes has been equipped with a rotatable mount and means for locking the mount at various angles of rotation for easy accessibility. The rotatable mount includes a horizontal conduit supported by bearings within the blank module. The conduit is spring-biased in a retracted position within the blank module and in this position a small gear mounted on the conduit periphery is locked by a fixed pawl. The conduit and instrument mount can be pulled into an extended position with the gear clearing the pawl to permit rotation and adjustment of the instrument.

  1. Foundations of measurement and instrumentation

    NASA Technical Reports Server (NTRS)

    Warshawsky, Isidore

    1990-01-01

    The user of instrumentation has provided an understanding of the factors that influence instrument performance, selection, and application, and of the methods of interpreting and presenting the results of measurements. Such understanding is prerequisite to the successful attainment of the best compromise among reliability, accuracy, speed, cost, and importance of the measurement operation in achieving the ultimate goal of a project. Some subjects covered are dimensions; units; sources of measurement error; methods of describing and estimating accuracy; deduction and presentation of results through empirical equations, including the method of least squares; experimental and analytical methods of determining the static and dynamic behavior of instrumentation systems, including the use of analogs.

  2. Commissioning Instrument for the GTC

    NASA Astrophysics Data System (ADS)

    Cuevas, S.; Sánchez, B.; Bringas, V.; Espejo, C.; Flores, R.; Chapa, O.; Lara, G.; Chavolla, A.; Anguiano, G.; Arciniega, S.; Dorantes, A.; González, J. L.; Montoya, J. M.; Toral, R.; Hernández, H.; Nava, R.; Devaney, N.; Castro, J.; Cavaller-Marqués, L.

    2005-12-01

    During the GTC integration phase, the Commissioning Instrument (CI) will be a diagnostic tool for performance verification. The CI features four operation modes: imaging, pupil imaging, Curvature WFS, and high resolution Shack-Hartmann WFS. This instrument was built by the Instituto de Astronomía UNAM and the Centro de Ingeniería y Desarrollo Industrial (CIDESI) under GRANTECAN contract after a public bid. In this paper we made a general instrument overview and we show some of the performance final results obtained when the Factory Acceptance tests previous to its transport to La Palma.

  3. Genetic markers as instrumental variables

    PubMed Central

    von Hinke, Stephanie; Davey Smith, George; Lawlor, Debbie A.; Propper, Carol; Windmeijer, Frank

    2016-01-01

    The use of genetic markers as instrumental variables (IV) is receiving increasing attention from economists, statisticians, epidemiologists and social scientists. Although IV is commonly used in economics, the appropriate conditions for the use of genetic variants as instruments have not been well defined. The increasing availability of biomedical data, however, makes understanding of these conditions crucial to the successful use of genotypes as instruments. We combine the econometric IV literature with that from genetic epidemiology, and discuss the biological conditions and IV assumptions within the statistical potential outcomes framework. We review this in the context of two illustrative applications. PMID:26614692

  4. Geo-conservation: an example of the application of its principles in the sanitation of the polluted Laarder Wasmeren area near Hilversum, het Gooi, The Netherlands.

    NASA Astrophysics Data System (ADS)

    Sevink, Jan; Khodabux, Eric; Landsmeer, Dick; Stoeten, Jan

    2013-04-01

    The Laarder Wasmeren area near Hilversum, a nature reserve under management of the Goois Natuurreservaat with extensive drift sands and several fens, was heavily polluted by heavy metals and toxic organic substances as a result of prolonged discharge of sewage water onto the fens. Already upon the start of its environmental restoration in 2004, it became clear that the area holds important geological phenomena, including LateGlacial paleosols and multiple Holocene drift sands with intercalated paleosols. This discovery induced the Province of Noord-Holland in 2006 to declare het Gooi, of which the Laarder Wasmeren area forms part, a geological monument and thus to set limits for future activities that might lead to disturbance of its superficial geology. Today het Gooi is one of the 17 geological monuments of the province. The basic principle of provincial geo-conservation - minimal disturbance of the superficial geology - was also applied in the further restoration of the LWM area that included its ecological restoration as a nature reserve. This restoration project was supervised by the author and belongs to the major operations of that kind in the Netherlands. Completed in 2010/2011, it resulted in the discovery and conservation of a complex of Holocene drift sands and paleosols that is unique for the Netherlands. The project forms an excellent example of the application of a provincial geo-conservation policy.

  5. Geo-conservation: an example of the application of its principles in the sanitation of the polluted Laarder Wasmeren area near Hilversum, het Gooi, The Netherlands

    NASA Astrophysics Data System (ADS)

    Sevink, J.; Khodabux, E. R.; Landsmeer, D.; Stoeten, G. J.

    2012-04-01

    The Laarder Wasmeren area near Hilversum, a nature reserve under management of the Goois Natuurreservaat with extensive drift sands and several fens, was heavily polluted by heavy metals and toxic organic substances as a result of prolonged discharge of sewage water onto the fens. Already upon the start of its environmental restoration in 2004, it became clear that the area holds important geological phenomena, including LateGlacial paleosols and multiple Holocene drift sands with intercalated paleosols. This discovery induced the Province of Noord-Holland in 2006 to declare het Gooi, of which the Laarder Wasmeren area forms part, a geological monument and thus to set limits for future activities that might lead to disturbance of its superficial geology. Today het Gooi is one of the 17 geological monuments of the province. The basic principle of provincial geo-conservation - minimal disturbance of the superficial geology - was also applied in the further restoration of the LWM area that included its ecological restoration as a nature reserve. This restoration project was supervised by the author and belongs to the major operations of that kind in the Netherlands. Completed in 2010/2011, it resulted in the discovery and conservation of a complex of Holocene drift sands and paleosols that is unique for the Netherlands. The project forms an excellent example of the application of a provincial geo-conservation policy.

  6. [Drug advertising as communication between the pharmaceutical industry and the physician: advertisements for psychotropic drugs in the Dutch medical journal, Nederlands Tijdschrift voor Geneeskunde, 1900-1940].

    PubMed

    van der Hoogte, Arjo Roersch; Pieters, Toine

    2010-01-01

    In this article we explore the historical development of drug advertisements for psychotropic drugs in the leading Dutch medical journal from 1900 to 1940. The advertisements for hypnotics and sedatives, in The Nederlands Tijdschrift voor Geneeskunde (Dutch medical journal) reflected the changes in the vocabulary and image promoted by the pharmaceutical companies. In the first two decades, the advertisements were sober and to the point, and included the trademark, company name, molecular formula and therapeutic properties of the medication. The emphasis was on creating a scientific image of reliable symptom control for the therapeutic drug. In doing so, the ethical drug companies tried (successfully) to distinguish themselves from the producers of patent medicines. Once scientific credibility was established, the form and content of the advertisements changed significantly. In the late 1920s and 1930s drug companies embraced modern advertising techniques, developing a figurative language to address the changing beliefs and practices of Dutch physicians. Instead of promoting therapeutic drugs as safe and scientific, the emphasis was on their effectiveness in comparison to similar drugs. In the process, scientific information was reduced to an indispensable standardized minimum, whereby therapeutic drugs were advertised according to the latest pharmacological taxonomy rather than molecular formulas. The image-making of 'ethical marketing' began during the interwar years when marketers applied modern advertising techniques and infotainment strategies. The scanty black and white informational bulletins transitioned into colourful advertisements. The pharmaceutical companies employed the same medical language as used by physicians, so that one word or image in an advertisement would suffice for the physician to recognize a drug and its therapeutic properties. These developments show the changing relationship between the modern ethical pharmaceutical industry and Dutch

  7. Aircraft Power-Plant Instruments

    NASA Technical Reports Server (NTRS)

    Sontag, Harcourt; Brombacher, W G

    1934-01-01

    This report supersedes NACA-TR-129 which is now obsolete. Aircraft power-plant instruments include tachometers, engine thermometers, pressure gages, fuel-quantity gages, fuel flow meters and indicators, and manifold pressure gages. The report includes a description of the commonly used types and some others, the underlying principle utilized in the design, and some design data. The inherent errors of the instrument, the methods of making laboratory tests, descriptions of the test apparatus, and data in considerable detail in the performance of commonly used instruments are presented. Standard instruments and, in cases where it appears to be of interest, those used as secondary standards are described. A bibliography of important articles is included.

  8. Modular Approach to Instrumental Analysis.

    ERIC Educational Resources Information Center

    Deming, Richard L.; And Others

    1982-01-01

    To remedy certain deficiencies, an instrument analysis course was reorganized into six one-unit modules: optical spectroscopy, magnetic resonance, separations, electrochemistry, radiochemistry, and computers and interfacing. Selected aspects of the course are discussed. (SK)

  9. Spacecraft instrument technology and cosmochemistry

    PubMed Central

    McSween, Harry Y.; McNutt, Ralph L.; Prettyman, Thomas H.

    2011-01-01

    Measurements by instruments on spacecraft have significantly advanced cosmochemistry. Spacecraft missions impose serious limitations on instrument volume, mass, and power, so adaptation of laboratory instruments drives technology. We describe three examples of flight instruments that collected cosmochemical data. Element analyses by Alpha Particle X-ray Spectrometers on the Mars Exploration Rovers have revealed the nature of volcanic rocks and sedimentary deposits on Mars. The Gamma Ray Spectrometer on the Lunar Prospector orbiter provided a global database of element abundances that resulted in a new understanding of the Moon’s crust. The Ion and Neutral Mass Spectrometer on Cassini has analyzed the chemical compositions of the atmosphere of Titan and active plumes on Enceladus. PMID:21402932

  10. ISIS Support for Dawn Instruments

    NASA Astrophysics Data System (ADS)

    Becker, K. J.; Anderson, J. A.; Barrett, J. M.; Sides, S. C.; Titus, T. N.

    2012-03-01

    The USGS ISIS system now includes support for the Dawn FC and VIR instruments with ingestion and camera/sensor model software. This provides the scientific community with the means to process Dawn image data into geologic maps.