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Sample records for integral hybrid monte

  1. Testing and tuning symplectic integrators for the hybrid Monte Carlo algorithm in lattice QCD

    SciTech Connect

    Takaishi, Tetsuya; Forcrand, Philippe de

    2006-03-15

    We examine a new second-order integrator recently found by Omelyan et al. The integration error of the new integrator measured in the root mean square of the energy difference, <{delta}H{sup 2}>{sup 1/2}, is about 10 times smaller than that of the standard second-order leapfrog (2LF) integrator. As a result, the step size of the new integrator can be made about three times larger. Taking into account a factor 2 increase in cost, the new integrator is about 50% more efficient than the 2LF integrator. Integrating over positions first, then momenta, is slightly more advantageous than the reverse. Further parameter tuning is possible. We find that the optimal parameter for the new integrator is slightly different from the value obtained by Omelyan et al., and depends on the simulation parameters. This integrator could also be advantageous for the Trotter-Suzuki decomposition in quantum Monte Carlo.

  2. Efficient ab initio path integral hybrid Monte Carlo based on the fourth-order Trotter expansion: Application to fluoride ion-water cluster.

    PubMed

    Suzuki, Kimichi; Tachikawa, Masanori; Shiga, Motoyuki

    2010-04-14

    We propose an efficient path integral hybrid Monte Carlo (PIHMC) method based on fourth-order Trotter expansion. Here, the second-order effective force is employed to generate short trial trajectories to avoid computationally expensive Hessian matrix, while the final acceptance is judged based on fourth-order effective potential. The computational performance of our PIHMC scheme is compared with that of conventional PIHMC and PIMD methods based on second- and fourth-order Trotter expansions. Our method is applied to on-the-fly ab initio PIHMC calculation of fluoride ion-water complexes, F(-)(H(2)O) and F(-)(D(2)O), at ambient temperature, particularly focusing on the geometrical isotope effect. PMID:20405986

  3. The Rational Hybrid Monte Carlo algorithm

    NASA Astrophysics Data System (ADS)

    Clark, Michael

    2006-12-01

    The past few years have seen considerable progress in algorithmic development for the generation of gauge fields including the effects of dynamical fermions. The Rational Hybrid Monte Carlo (RHMC) algorithm, where Hybrid Monte Carlo is performed using a rational approximation in place the usual inverse quark matrix kernel is one of these developments. This algorithm has been found to be extremely beneficial in many areas of lattice QCD (chiral fermions, finite temperature, Wilson fermions etc.). We review the algorithm and some of these benefits, and we compare against other recent algorithm developements. We conclude with an update of the Berlin wall plot comparing costs of all popular fermion formulations.

  4. A separable shadow Hamiltonian hybrid Monte Carlo method

    NASA Astrophysics Data System (ADS)

    Sweet, Christopher R.; Hampton, Scott S.; Skeel, Robert D.; Izaguirre, Jesús A.

    2009-11-01

    Hybrid Monte Carlo (HMC) is a rigorous sampling method that uses molecular dynamics (MD) as a global Monte Carlo move. The acceptance rate of HMC decays exponentially with system size. The shadow hybrid Monte Carlo (SHMC) was previously introduced to reduce this performance degradation by sampling instead from the shadow Hamiltonian defined for MD when using a symplectic integrator. SHMC's performance is limited by the need to generate momenta for the MD step from a nonseparable shadow Hamiltonian. We introduce the separable shadow Hamiltonian hybrid Monte Carlo (S2HMC) method based on a formulation of the leapfrog/Verlet integrator that corresponds to a separable shadow Hamiltonian, which allows efficient generation of momenta. S2HMC gives the acceptance rate of a fourth order integrator at the cost of a second-order integrator. Through numerical experiments we show that S2HMC consistently gives a speedup greater than two over HMC for systems with more than 4000 atoms for the same variance. By comparison, SHMC gave a maximum speedup of only 1.6 over HMC. S2HMC has the additional advantage of not requiring any user parameters beyond those of HMC. S2HMC is available in the program PROTOMOL 2.1. A Python version, adequate for didactic purposes, is also in MDL (http://mdlab.sourceforge.net/s2hmc).

  5. Multiple-time-stepping generalized hybrid Monte Carlo methods

    NASA Astrophysics Data System (ADS)

    Escribano, Bruno; Akhmatskaya, Elena; Reich, Sebastian; Azpiroz, Jon M.

    2015-01-01

    Performance of the generalized shadow hybrid Monte Carlo (GSHMC) method [1], which proved to be superior in sampling efficiency over its predecessors [2-4], molecular dynamics and hybrid Monte Carlo, can be further improved by combining it with multi-time-stepping (MTS) and mollification of slow forces. We demonstrate that the comparatively simple modifications of the method not only lead to better performance of GSHMC itself but also allow for beating the best performed methods, which use the similar force splitting schemes. In addition we show that the same ideas can be successfully applied to the conventional generalized hybrid Monte Carlo method (GHMC). The resulting methods, MTS-GHMC and MTS-GSHMC, provide accurate reproduction of thermodynamic and dynamical properties, exact temperature control during simulation and computational robustness and efficiency. MTS-GHMC uses a generalized momentum update to achieve weak stochastic stabilization to the molecular dynamics (MD) integrator. MTS-GSHMC adds the use of a shadow (modified) Hamiltonian to filter the MD trajectories in the HMC scheme. We introduce a new shadow Hamiltonian formulation adapted to force-splitting methods. The use of such Hamiltonians improves the acceptance rate of trajectories and has a strong impact on the sampling efficiency of the method. Both methods were implemented in the open-source MD package ProtoMol and were tested on a water and a protein systems. Results were compared to those obtained using a Langevin Molly (LM) method [5] on the same systems. The test results demonstrate the superiority of the new methods over LM in terms of stability, accuracy and sampling efficiency. This suggests that putting the MTS approach in the framework of hybrid Monte Carlo and using the natural stochasticity offered by the generalized hybrid Monte Carlo lead to improving stability of MTS and allow for achieving larger step sizes in the simulation of complex systems.

  6. Multiple-time-stepping generalized hybrid Monte Carlo methods

    SciTech Connect

    Escribano, Bruno; Akhmatskaya, Elena; Reich, Sebastian; Azpiroz, Jon M.

    2015-01-01

    Performance of the generalized shadow hybrid Monte Carlo (GSHMC) method [1], which proved to be superior in sampling efficiency over its predecessors [2–4], molecular dynamics and hybrid Monte Carlo, can be further improved by combining it with multi-time-stepping (MTS) and mollification of slow forces. We demonstrate that the comparatively simple modifications of the method not only lead to better performance of GSHMC itself but also allow for beating the best performed methods, which use the similar force splitting schemes. In addition we show that the same ideas can be successfully applied to the conventional generalized hybrid Monte Carlo method (GHMC). The resulting methods, MTS-GHMC and MTS-GSHMC, provide accurate reproduction of thermodynamic and dynamical properties, exact temperature control during simulation and computational robustness and efficiency. MTS-GHMC uses a generalized momentum update to achieve weak stochastic stabilization to the molecular dynamics (MD) integrator. MTS-GSHMC adds the use of a shadow (modified) Hamiltonian to filter the MD trajectories in the HMC scheme. We introduce a new shadow Hamiltonian formulation adapted to force-splitting methods. The use of such Hamiltonians improves the acceptance rate of trajectories and has a strong impact on the sampling efficiency of the method. Both methods were implemented in the open-source MD package ProtoMol and were tested on a water and a protein systems. Results were compared to those obtained using a Langevin Molly (LM) method [5] on the same systems. The test results demonstrate the superiority of the new methods over LM in terms of stability, accuracy and sampling efficiency. This suggests that putting the MTS approach in the framework of hybrid Monte Carlo and using the natural stochasticity offered by the generalized hybrid Monte Carlo lead to improving stability of MTS and allow for achieving larger step sizes in the simulation of complex systems.

  7. GATE Monte Carlo simulations for variations of an integrated PET/MR hybrid imaging system based on the Biograph mMR model

    NASA Astrophysics Data System (ADS)

    Aklan, B.; Jakoby, B. W.; Watson, C. C.; Braun, H.; Ritt, P.; Quick, H. H.

    2015-06-01

    A simulation toolkit, GATE (Geant4 Application for Tomographic Emission), was used to develop an accurate Monte Carlo (MC) simulation of a fully integrated 3T PET/MR hybrid imaging system (Siemens Biograph mMR). The PET/MR components of the Biograph mMR were simulated in order to allow a detailed study of variations of the system design on the PET performance, which are not easy to access and measure on a real PET/MR system. The 3T static magnetic field of the MR system was taken into account in all Monte Carlo simulations. The validation of the MC model was carried out against actual measurements performed on the PET/MR system by following the NEMA (National Electrical Manufacturers Association) NU 2-2007 standard. The comparison of simulated and experimental performance measurements included spatial resolution, sensitivity, scatter fraction, and count rate capability. The validated system model was then used for two different applications. The first application focused on investigating the effect of an extension of the PET field-of-view on the PET performance of the PET/MR system. The second application deals with simulating a modified system timing resolution and coincidence time window of the PET detector electronics in order to simulate time-of-flight (TOF) PET detection. A dedicated phantom was modeled to investigate the impact of TOF on overall PET image quality. Simulation results showed that the overall divergence between simulated and measured data was found to be less than 10%. Varying the detector geometry showed that the system sensitivity and noise equivalent count rate of the PET/MR system increased progressively with an increasing number of axial detector block rings, as to be expected. TOF-based PET reconstructions of the modeled phantom showed an improvement in signal-to-noise ratio and image contrast to the conventional non-TOF PET reconstructions. In conclusion, the validated MC simulation model of an integrated PET/MR system with an overall accuracy error of less than 10% can now be used for further MC simulation applications such as development of hardware components as well as for testing of new PET/MR software algorithms, such as assessment of point-spread function-based reconstruction algorithms.

  8. GATE Monte Carlo simulations for variations of an integrated PET/MR hybrid imaging system based on the Biograph mMR model.

    PubMed

    Aklan, B; Jakoby, B W; Watson, C C; Braun, H; Ritt, P; Quick, H H

    2015-06-21

    A simulation toolkit, GATE (Geant4 Application for Tomographic Emission), was used to develop an accurate Monte Carlo (MC) simulation of a fully integrated 3T PET/MR hybrid imaging system (Siemens Biograph mMR). The PET/MR components of the Biograph mMR were simulated in order to allow a detailed study of variations of the system design on the PET performance, which are not easy to access and measure on a real PET/MR system. The 3T static magnetic field of the MR system was taken into account in all Monte Carlo simulations. The validation of the MC model was carried out against actual measurements performed on the PET/MR system by following the NEMA (National Electrical Manufacturers Association) NU 2-2007 standard. The comparison of simulated and experimental performance measurements included spatial resolution, sensitivity, scatter fraction, and count rate capability. The validated system model was then used for two different applications. The first application focused on investigating the effect of an extension of the PET field-of-view on the PET performance of the PET/MR system. The second application deals with simulating a modified system timing resolution and coincidence time window of the PET detector electronics in order to simulate time-of-flight (TOF) PET detection. A dedicated phantom was modeled to investigate the impact of TOF on overall PET image quality. Simulation results showed that the overall divergence between simulated and measured data was found to be less than 10%. Varying the detector geometry showed that the system sensitivity and noise equivalent count rate of the PET/MR system increased progressively with an increasing number of axial detector block rings, as to be expected. TOF-based PET reconstructions of the modeled phantom showed an improvement in signal-to-noise ratio and image contrast to the conventional non-TOF PET reconstructions. In conclusion, the validated MC simulation model of an integrated PET/MR system with an overall accuracy error of less than 10% can now be used for further MC simulation applications such as development of hardware components as well as for testing of new PET/MR software algorithms, such as assessment of point-spread function-based reconstruction algorithms. PMID:26040657

  9. Hybrid optofluidic integration

    PubMed Central

    Parks, Joshua W.; Cai, Hong; Zempoaltecatl, Lynnell; Yuzvinsky, Thomas D.; Leake, Kaelyn; Hawkins, Aaron R.

    2013-01-01

    Complete integration of microfluidic and optical functions in a single lab-on-chip device is one goal of optofluidics. Here, we demonstrate the hybrid integration of a PDMS-based fluid handling layer with a silicon-based optical detection layer in a single optofluidic system. The optical layer consists of a liquid-core antiresonant reflecting optical waveguide (ARROW) chip that is capable of single particle detection and interfacing with optical fiber. Integrated devices are reconfigurable and able to sustain high pressures despite the small dimensions of the liquid-core waveguide channels. We show the combination of salient sample preparation capabilities—particle mixing, distribution, and filtering—with single particle fluorescence detection. Specifically, we demonstrate fluorescent labelling of λ-DNA, followed by flow-based single-molecule detection on a single device. This points the way towards amplification-free detection of nucleic acids with low-complexity biological sample preparation on a chip. PMID:23969694

  10. Hybrid optofluidic integration.

    PubMed

    Parks, Joshua W; Cai, Hong; Zempoaltecatl, Lynnell; Yuzvinsky, Thomas D; Leake, Kaelyn; Hawkins, Aaron R; Schmidt, Holger

    2013-10-21

    Complete integration of microfluidic and optical functions in a single lab-on-chip device is one goal of optofluidics. Here, we demonstrate the hybrid integration of a PDMS-based fluid handling layer with a silicon-based optical detection layer in a single optofluidic system. The optical layer consists of a liquid-core antiresonant reflecting optical waveguide (ARROW) chip that is capable of single particle detection and interfacing with optical fiber. Integrated devices are reconfigurable and able to sustain high pressures despite the small dimensions of the liquid-core waveguide channels. We show the combination of salient sample preparation capabilities-particle mixing, distribution, and filtering-with single particle fluorescence detection. Specifically, we demonstrate fluorescent labelling of λ-DNA, followed by flow-based single-molecule detection on a single device. This points the way towards amplification-free detection of nucleic acids with low-complexity biological sample preparation on a chip. PMID:23969694

  11. The Hybrid Monte Carlo Algorithm and the chiral transition

    NASA Astrophysics Data System (ADS)

    Gupta, Rajan

    1988-04-01

    In this talk I describe tests of the Hybrid Monte Carlo Algorithm for QCD done in collaboration with Greg Kilcup and Stephen Sharpe. We find that the acceptance in the global Metropolis step for Staggered fermions can be tuned and kept large without having to make the step-size prohibitively small. We present results for the finite temperature transition on 4 4 and 4 × 6 3 lattices using this algorithm.

  12. Hybrid optoelectronic integrated circuit.

    PubMed

    Macdonald, R I; Lam, D K; Syrett, B A

    1987-03-01

    The distribution of optical signals to a monolithic array of GaAs photoconductors by means of ion-exchanged glass optical waveguides is demonstrated. In this hybrid technique both optical and electronic interconnections of semiconductor elements are achieved through the use of a metallic interconnect layer deposited on the surface of a glass substrate which has a mating waveguide pattern. The low optical loss, ease of fabrication, and low material cost of diffused glass waveguides with such layers permit relatively large optoelectronic circuit boards to be made, in which numerous semiconductor active optoelectronic devices can be included. The device reported here serves as the signal distribution and cross-point switching section of an optoelectronic switch matrix. PMID:20454231

  13. Bayesian estimation of realized stochastic volatility model by Hybrid Monte Carlo algorithm

    NASA Astrophysics Data System (ADS)

    Takaishi, Tetsuya

    2014-03-01

    The hybrid Monte Carlo algorithm (HMCA) is applied for Bayesian parameter estimation of the realized stochastic volatility (RSV) model. Using the 2nd order minimum norm integrator (2MNI) for the molecular dynamics (MD) simulation in the HMCA, we find that the 2MNI is more efficient than the conventional leapfrog integrator. We also find that the autocorrelation time of the volatility variables sampled by the HMCA is very short. Thus it is concluded that the HMCA with the 2MNI is an efficient algorithm for parameter estimations of the RSV model.

  14. A Primer in Monte Carlo Integration Using Mathcad

    ERIC Educational Resources Information Center

    Hoyer, Chad E.; Kegerreis, Jeb S.

    2013-01-01

    The essentials of Monte Carlo integration are presented for use in an upper-level physical chemistry setting. A Mathcad document that aids in the dissemination and utilization of this information is described and is available in the Supporting Information. A brief outline of Monte Carlo integration is given, along with ideas and pedagogy for

  15. A Primer in Monte Carlo Integration Using Mathcad

    ERIC Educational Resources Information Center

    Hoyer, Chad E.; Kegerreis, Jeb S.

    2013-01-01

    The essentials of Monte Carlo integration are presented for use in an upper-level physical chemistry setting. A Mathcad document that aids in the dissemination and utilization of this information is described and is available in the Supporting Information. A brief outline of Monte Carlo integration is given, along with ideas and pedagogy for…

  16. A hybrid Monte Carlo and response matrix Monte Carlo method in criticality calculation

    SciTech Connect

    Li, Z.; Wang, K.

    2012-07-01

    Full core calculations are very useful and important in reactor physics analysis, especially in computing the full core power distributions, optimizing the refueling strategies and analyzing the depletion of fuels. To reduce the computing time and accelerate the convergence, a method named Response Matrix Monte Carlo (RMMC) method based on analog Monte Carlo simulation was used to calculate the fixed source neutron transport problems in repeated structures. To make more accurate calculations, we put forward the RMMC method based on non-analog Monte Carlo simulation and investigate the way to use RMMC method in criticality calculations. Then a new hybrid RMMC and MC (RMMC+MC) method is put forward to solve the criticality problems with combined repeated and flexible geometries. This new RMMC+MC method, having the advantages of both MC method and RMMC method, can not only increase the efficiency of calculations, also simulate more complex geometries rather than repeated structures. Several 1-D numerical problems are constructed to test the new RMMC and RMMC+MC method. The results show that RMMC method and RMMC+MC method can efficiently reduce the computing time and variations in the calculations. Finally, the future research directions are mentioned and discussed at the end of this paper to make RMMC method and RMMC+MC method more powerful. (authors)

  17. Quantum photonics hybrid integration platform

    NASA Astrophysics Data System (ADS)

    Murray, E.; Ellis, D. J. P.; Meany, T.; Floether, F. F.; Lee, J. P.; Griffiths, J. P.; Jones, G. A. C.; Farrer, I.; Ritchie, D. A.; Bennett, A. J.; Shields, A. J.

    2015-10-01

    Fundamental to integrated photonic quantum computing is an on-chip method for routing and modulating quantum light emission. We demonstrate a hybrid integration platform consisting of arbitrarily designed waveguide circuits and single-photon sources. InAs quantum dots (QD) embedded in GaAs are bonded to a SiON waveguide chip such that the QD emission is coupled to the waveguide mode. The waveguides are SiON core embedded in a SiO2 cladding. A tuneable Mach Zehnder interferometer (MZI) modulates the emission between two output ports and can act as a path-encoded qubit preparation device. The single-photon nature of the emission was verified using the on-chip MZI as a beamsplitter in a Hanbury Brown and Twiss measurement.

  18. Monte Carlo Hybrid Applied to Binary Stochastic Mixtures

    SciTech Connect

    Keady, K. P.

    2008-08-11

    The purpose of this set of codes isto use an inexpensive, approximate deterministic flux distribution to generate weight windows, wihich will then be used to bound particle weights for the Monte Carlo code run. The process is not automated; the user must run the deterministic code and use the output file as a command-line argument for the Monte Carlo code. Two sets of text input files are included as test problems/templates.

  19. Path integral Monte Carlo and the electron gas

    NASA Astrophysics Data System (ADS)

    Brown, Ethan W.

    Path integral Monte Carlo is a proven method for accurately simulating quantum mechanical systems at finite-temperature. By stochastically sampling Feynman's path integral representation of the quantum many-body density matrix, path integral Monte Carlo includes non-perturbative effects like thermal fluctuations and particle correlations in a natural way. Over the past 30 years, path integral Monte Carlo has been successfully employed to study the low density electron gas, high-pressure hydrogen, and superfluid helium. For systems where the role of Fermi statistics is important, however, traditional path integral Monte Carlo simulations have an exponentially decreasing efficiency with decreased temperature and increased system size. In this thesis, we work towards improving this efficiency, both through approximate and exact methods, as specifically applied to the homogeneous electron gas. We begin with a brief overview of the current state of atomic simulations at finite-temperature before we delve into a pedagogical review of the path integral Monte Carlo method. We then spend some time discussing the one major issue preventing exact simulation of Fermi systems, the sign problem. Afterwards, we introduce a way to circumvent the sign problem in PIMC simulations through a fixed-node constraint. We then apply this method to the homogeneous electron gas at a large swatch of densities and temperatures in order to map out the warm-dense matter regime. The electron gas can be a representative model for a host of real systems, from simple medals to stellar interiors. However, its most common use is as input into density functional theory. To this end, we aim to build an accurate representation of the electron gas from the ground state to the classical limit and examine its use in finite-temperature density functional formulations. The latter half of this thesis focuses on possible routes beyond the fixed-node approximation. As a first step, we utilize the variational principle inherent in the path integral Monte Carlo method to optimize the nodal surface. By using a ansatz resembling a free particle density matrix, we make a unique connection between a nodal effective mass and the traditional effective mass of many-body quantum theory. We then propose and test several alternate nodal ansatzes and apply them to single atomic systems. Finally, we propose a method to tackle the sign problem head on, by leveraging the relatively simple structure of permutation space. Using this method, we find we can perform exact simulations this of the electron gas and 3He that were previously impossible.

  20. Multiple Time-Step Dual-Hamiltonian Hybrid Molecular Dynamics - Monte Carlo Canonical Propagation Algorithm.

    PubMed

    Chen, Yunjie; Kale, Seyit; Weare, Jonathan; Dinner, Aaron R; Roux, Benoît

    2016-04-12

    A multiple time-step integrator based on a dual Hamiltonian and a hybrid method combining molecular dynamics (MD) and Monte Carlo (MC) is proposed to sample systems in the canonical ensemble. The Dual Hamiltonian Multiple Time-Step (DHMTS) algorithm is based on two similar Hamiltonians: a computationally expensive one that serves as a reference and a computationally inexpensive one to which the workload is shifted. The central assumption is that the difference between the two Hamiltonians is slowly varying. Earlier work has shown that such dual Hamiltonian multiple time-step schemes effectively precondition nonlinear differential equations for dynamics by reformulating them into a recursive root finding problem that can be solved by propagating a correction term through an internal loop, analogous to RESPA. Of special interest in the present context, a hybrid MD-MC version of the DHMTS algorithm is introduced to enforce detailed balance via a Metropolis acceptance criterion and ensure consistency with the Boltzmann distribution. The Metropolis criterion suppresses the discretization errors normally associated with the propagation according to the computationally inexpensive Hamiltonian, treating the discretization error as an external work. Illustrative tests are carried out to demonstrate the effectiveness of the method. PMID:26918826

  1. Path integral Monte Carlo on a lattice: Extended states

    NASA Astrophysics Data System (ADS)

    O'Callaghan, Mark; Miller, Bruce N.

    2014-04-01

    The equilibrium properties of a single quantum particle (qp) interacting with a classical gas for a wide range of temperatures that explore the system's behavior in the classical as well as in the quantum regime is investigated. Both the qp and atoms are restricted to the sites of a one-dimensional lattice. A path integral formalism is developed within the context of the canonical ensemble in which the qp is represented by a closed, variable-step random walk on the lattice. Monte Carlo methods are employed to determine the system's properties. For the case of a free particle, analytical expressions for the energy, its fluctuations, and the qp-qp correlation function are derived and compared with the Monte Carlo simulations. To test the usefulness of the path integral formalism, the Metropolis algorithm is employed to determine the equilibrium properties of the qp for a periodic interaction potential, forcing the qp to occupy extended states. We consider a striped potential in one dimension, where every other lattice site is occupied by an atom with potential ɛ, and every other lattice site is empty. This potential serves as a stress test for the path integral formalism because of its rapid site-to-site variation. An analytical solution was determined in this case by utilizing Bloch's theorem due to the periodicity of the potential. Comparisons of the potential energy, the total energy, the energy fluctuations, and the correlation function are made between the results of the Monte Carlo simulations and the analytical calculations.

  2. Path integral Monte Carlo on a lattice: extended states.

    PubMed

    O'Callaghan, Mark; Miller, Bruce N

    2014-04-01

    The equilibrium properties of a single quantum particle (qp) interacting with a classical gas for a wide range of temperatures that explore the system's behavior in the classical as well as in the quantum regime is investigated. Both the qp and atoms are restricted to the sites of a one-dimensional lattice. A path integral formalism is developed within the context of the canonical ensemble in which the qp is represented by a closed, variable-step random walk on the lattice. Monte Carlo methods are employed to determine the system's properties. For the case of a free particle, analytical expressions for the energy, its fluctuations, and the qp-qp correlation function are derived and compared with the Monte Carlo simulations. To test the usefulness of the path integral formalism, the Metropolis algorithm is employed to determine the equilibrium properties of the qp for a periodic interaction potential, forcing the qp to occupy extended states. We consider a striped potential in one dimension, where every other lattice site is occupied by an atom with potential ε, and every other lattice site is empty. This potential serves as a stress test for the path integral formalism because of its rapid site-to-site variation. An analytical solution was determined in this case by utilizing Bloch's theorem due to the periodicity of the potential. Comparisons of the potential energy, the total energy, the energy fluctuations, and the correlation function are made between the results of the Monte Carlo simulations and the analytical calculations. PMID:24827210

  3. Monte Carlo Integration Using Spatial Structure of Markov Random Field

    NASA Astrophysics Data System (ADS)

    Yasuda, Muneki

    2015-03-01

    Monte Carlo integration (MCI) techniques are important in various fields. In this study, a new MCI technique for Markov random fields (MRFs) is proposed. MCI consists of two successive parts: the first involves sampling using a technique such as the Markov chain Monte Carlo method, and the second involves an averaging operation using the obtained sample points. In the averaging operation, a simple sample averaging technique is often employed. The method proposed in this paper improves the averaging operation by addressing the spatial structure of the MRF and is mathematically guaranteed to statistically outperform standard MCI using the simple sample averaging operation. Moreover, the proposed method can be improved in a systematic manner and is numerically verified by numerical simulations using planar Ising models. In the latter part of this paper, the proposed method is applied to the inverse Ising problem and we observe that it outperforms the maximum pseudo-likelihood estimation.

  4. Hybrid manufacturing : integrating direct write and sterolithography.

    SciTech Connect

    Davis, Donald W.; Inamdar, Asim; Lopes, Amit; Chavez, Bart D.; Gallegos, Phillip L.; Palmer, Jeremy Andrew; Wicker, Ryan B.; Medina, Francisco; Hennessey, Robert E.

    2005-07-01

    A commercial stereolithography (SL) machine was modified to integrate fluid dispensing or direct-write (DW) technology with SL in an integrated manufacturing environment for automated and efficient hybrid manufacturing of complex electrical devices, combining three-dimensional (3D) electrical circuitry with SL-manufactured parts. The modified SL system operates similarly to a commercially available machine, although build interrupts were used to stop and start the SL build while depositing fluid using the DW system. An additional linear encoder was attached to the SL platform z-stage and used to maintain accurate part registration during the SL and DW build processes. Individual STL files were required as part of the manufacturing process plan. The DW system employed a three-axis translation mechanism that was integrated with the commercial SL machine. Registration between the SL part, SL laser and the DW nozzle was maintained through the use of 0.025-inch diameter cylindrical reference holes manufactured in the part during SL. After depositing conductive ink using DW, the SL laser was commanded to trace the profile until the ink was cured. The current system allows for easy exchange between SL and DW in order to manufacture fully functional 3D electrical circuits and structures in a semi-automated environment. To demonstrate the manufacturing capabilities, the hybrid SL/DW setup was used to make a simple multi-layer SL part with embedded circuitry. This hybrid system is not intended to function as a commercial system, it is intended for experimental demonstration only. This hybrid SL/DW system has the potential for manufacturing fully functional electromechanical devices that are more compact, less expensive, and more reliable than their conventional predecessors, and work is ongoing in order to fully automate the current system.

  5. Monte Carlo modeling of an integrating sphere reflectometer.

    PubMed

    Prokhorov, Alexander V; Mekhontsev, Sergey N; Hanssen, Leonard M

    2003-07-01

    The Monte Carlo method has been applied to numerical modeling of an integrating sphere designed for hemispherical-directional reflectance factor measurements. It is shown that a conventional algorithm of backward ray tracing used for estimation of characteristics of the radiation field at a given point has slow convergence for small source-to-sphere-diameter ratios. A newly developed algorithm that substantially improves the convergence by calculation of direct source-induced irradiation for every point of diffuse reflection of rays traced is described. The method developed is applied to an integrating sphere reflectometer for the visible and infrared spectral ranges. Parametric studies of hemispherical radiance distributions for radiation incident onto the sample center were performed. The deviations of measured sample reflectance from the actual reflectance as a result of various factors were computed. The accuracy of the results, adequacy of the reflectance model, and other important aspects of the algorithm implementation are discussed. PMID:12868822

  6. Monte Carlo Simulations of Background Spectra in Integral Imager Detectors

    NASA Technical Reports Server (NTRS)

    Armstrong, T. W.; Colborn, B. L.; Dietz, K. L.; Ramsey, B. D.; Weisskopf, M. C.

    1998-01-01

    Predictions of the expected gamma-ray backgrounds in the ISGRI (CdTe) and PiCsIT (Csl) detectors on INTEGRAL due to cosmic-ray interactions and the diffuse gamma-ray background have been made using a coupled set of Monte Carlo radiation transport codes (HETC, FLUKA, EGS4, and MORSE) and a detailed, 3-D mass model of the spacecraft and detector assemblies. The simulations include both the prompt background component from induced hadronic and electromagnetic cascades and the delayed component due to emissions from induced radioactivity. Background spectra have been obtained with and without the use of active (BGO) shielding and charged particle rejection to evaluate the effectiveness of anticoincidence counting on background rejection.

  7. Path-Integral Monte Carlo Methods for Ultrasmall Device Modeling

    NASA Astrophysics Data System (ADS)

    Register, Leonard Franklin, II

    Monte Carlo methods based on the Feynman path -integral (FPI) formulation of quantum mechanics are developed for modeling ultrasmall device structures. A brief introduction to pertinent aspects of the FPI formalism is given. A practical "path-integral Monte Carlo" (PIMC) method for modeling equilibrium properties in ultrasmall devices is described and used to perform representative calculations of equilibrium properties of carrier confined in ultrasmall device structures, absent carrier-phonon coupling. As a spinoff of the PIMC research but without employing the FPI formalism, calculations of carrier-localized-phonon scattering rates for single and double optical-phonon-mode alloy semiconductors are performed, without assuming any specific functional form or degree of phonon localization. With the help of insights gained in the analysis of alloys semiconductors, the influence functional (the mathematical device for including carrier-phonon coupling effects in the FPI formalism) for carrier-polar-optical-phonon coupling is reexamined and generalized for heterostructures. An improved numerical method for evaluating the influence functional is developed. As a representative example of PIMC analysis of carrier-phonon coupling effects, calculations of carrier self-energies (the energy shift of carriers that results from coupling to phonons) in single crystals and quantum wires as a function of temperature are performed, though using the less general form of the influence functional for convenience and to allow comparison to previous results. A PIMC method appropriate for studying short-time transient behavior of carriers in ultrasmall devices is developed, examples given and the method compared to other transient-time PIMC methods. Based on this work, recommendations for future research are made.

  8. A Hybrid Monte Carlo-Deterministic Method for Global Binary Stochastic Medium Transport Problems

    SciTech Connect

    Keady, K P; Brantley, P

    2010-03-04

    Global deep-penetration transport problems are difficult to solve using traditional Monte Carlo techniques. In these problems, the scalar flux distribution is desired at all points in the spatial domain (global nature), and the scalar flux typically drops by several orders of magnitude across the problem (deep-penetration nature). As a result, few particle histories may reach certain regions of the domain, producing a relatively large variance in tallies in those regions. Implicit capture (also known as survival biasing or absorption suppression) can be used to increase the efficiency of the Monte Carlo transport algorithm to some degree. A hybrid Monte Carlo-deterministic technique has previously been developed by Cooper and Larsen to reduce variance in global problems by distributing particles more evenly throughout the spatial domain. This hybrid method uses an approximate deterministic estimate of the forward scalar flux distribution to automatically generate weight windows for the Monte Carlo transport simulation, avoiding the necessity for the code user to specify the weight window parameters. In a binary stochastic medium, the material properties at a given spatial location are known only statistically. The most common approach to solving particle transport problems involving binary stochastic media is to use the atomic mix (AM) approximation in which the transport problem is solved using ensemble-averaged material properties. The most ubiquitous deterministic model developed specifically for solving binary stochastic media transport problems is the Levermore-Pomraning (L-P) model. Zimmerman and Adams proposed a Monte Carlo algorithm (Algorithm A) that solves the Levermore-Pomraning equations and another Monte Carlo algorithm (Algorithm B) that is more accurate as a result of improved local material realization modeling. Recent benchmark studies have shown that Algorithm B is often significantly more accurate than Algorithm A (and therefore the L-P model) for deep penetration problems such as examined in this paper. In this research, we investigate the application of a variant of the hybrid Monte Carlo-deterministic method proposed by Cooper and Larsen to global deep penetration problems involving binary stochastic media. To our knowledge, hybrid Monte Carlo-deterministic methods have not previously been applied to problems involving a stochastic medium. We investigate two approaches for computing the approximate deterministic estimate of the forward scalar flux distribution used to automatically generate the weight windows. The first approach uses the atomic mix approximation to the binary stochastic medium transport problem and a low-order discrete ordinates angular approximation. The second approach uses the Levermore-Pomraning model for the binary stochastic medium transport problem and a low-order discrete ordinates angular approximation. In both cases, we use Monte Carlo Algorithm B with weight windows automatically generated from the approximate forward scalar flux distribution to obtain the solution of the transport problem.

  9. A comparison of generalized hybrid Monte Carlo methods with and without momentum flip

    SciTech Connect

    Akhmatskaya, Elena; Bou-Rabee, Nawaf; Reich, Sebastian

    2009-04-01

    The generalized hybrid Monte Carlo (GHMC) method combines Metropolis corrected constant energy simulations with a partial random refreshment step in the particle momenta. The standard detailed balance condition requires that momenta are negated upon rejection of a molecular dynamics proposal step. The implication is a trajectory reversal upon rejection, which is undesirable when interpreting GHMC as thermostated molecular dynamics. We show that a modified detailed balance condition can be used to implement GHMC without momentum flips. The same modification can be applied to the generalized shadow hybrid Monte Carlo (GSHMC) method. Numerical results indicate that GHMC/GSHMC implementations with momentum flip display a favorable behavior in terms of sampling efficiency, i.e., the traditional GHMC/GSHMC implementations with momentum flip got the advantage of a higher acceptance rate and faster decorrelation of Monte Carlo samples. The difference is more pronounced for GHMC. We also numerically investigate the behavior of the GHMC method as a Langevin-type thermostat. We find that the GHMC method without momentum flip interferes less with the underlying stochastic molecular dynamics in terms of autocorrelation functions and it to be preferred over the GHMC method with momentum flip. The same finding applies to GSHMC.

  10. Rational hybrid Monte Carlo algorithm for theories with unknown spectral bounds

    SciTech Connect

    Kogut, J. B.; Sinclair, D. K.

    2006-12-01

    The Rational Hybrid Monte Carlo (RHMC) algorithm extends the Hybrid Monte Carlo algorithm for lattice QCD simulations to situations involving fractional powers of the determinant of the quadratic Dirac operator. This avoids the updating increment (dt) dependence of observables which plagues the Hybrid Molecular-dynamics (HMD) method. The RHMC algorithm uses rational approximations to fractional powers of the quadratic Dirac operator. Such approximations are only available when positive upper and lower bounds to the operator's spectrum are known. We apply the RHMC algorithm to simulations of 2 theories for which a positive lower spectral bound is unknown: lattice QCD with staggered quarks at finite isospin chemical potential and lattice QCD with massless staggered quarks and chiral 4-fermion interactions ({chi}QCD). A choice of lower bound is made in each case, and the properties of the RHMC simulations these define are studied. Justification of our choices of lower bounds is made by comparing measurements with those from HMD simulations, and by comparing different choices of lower bounds.

  11. Rational hybrid Monte Carlo algorithm for theories with unknown spectral bounds.

    SciTech Connect

    Sinclair, D. K.; Kogut, J. B.; High Energy Physics; Univ. of Maryland

    2006-12-01

    The Rational Hybrid Monte Carlo (RHMC) algorithm extends the Hybrid Monte Carlo algorithm for lattice QCD simulations to situations involving fractional powers of the determinant of the quadratic Dirac operator. This avoids the updating increment (dt) dependence of observables which plagues the Hybrid Molecular-dynamics (HMD) method. The RHMC algorithm uses rational approximations to fractional powers of the quadratic Dirac operator. Such approximations are only available when positive upper and lower bounds to the operator's spectrum are known. We apply the RHMC algorithm to simulations of 2 theories for which a positive lower spectral bound is unknown: lattice QCD with staggered quarks at finite isospin chemical potential and lattice QCD with massless staggered quarks and chiral 4-fermion interactions (chiQCD). A choice of lower bound is made in each case, and the properties of the RHMC simulations these define are studied. Justification of our choices of lower bounds is made by comparing measurements with those from HMD simulations, and by comparing different choices of lower bounds.

  12. Hybrid two-dimensional Monte-Carlo electron transport in self-consistent electromagnetic fields

    SciTech Connect

    Mason, R.J.; Cranfill, C.W.

    1985-01-01

    The physics and numerics of the hybrid electron transport code ANTHEM are described. The need for the hybrid modeling of laser generated electron transport is outlined, and a general overview of the hybrid implementation in ANTHEM is provided. ANTHEM treats the background ions and electrons in a laser target as coupled fluid components moving relative to a fixed Eulerian mesh. The laser converts cold electrons to an additional hot electron component which evolves on the mesh as either a third coupled fluid or as a set of Monte Carlo PIC particles. The fluids and particles move in two-dimensions through electric and magnetic fields calculated via the Implicit Moment method. The hot electrons are coupled to the background thermal electrons by Coulomb drag, and both the hot and cold electrons undergo Rutherford scattering against the ion background. Subtleties of the implicit E- and B-field solutions, the coupled hydrodynamics, and large time step Monte Carlo particle scattering are discussed. Sample applications are presented.

  13. Rational hybrid MonteCarlo algorithm for theories with unknown spectral bounds

    NASA Astrophysics Data System (ADS)

    Kogut, J. B.; Sinclair, D. K.

    2006-12-01

    The Rational Hybrid Monte Carlo (RHMC) algorithm extends the Hybrid Monte Carlo algorithm for lattice QCD simulations to situations involving fractional powers of the determinant of the quadratic Dirac operator. This avoids the updating increment (dt) dependence of observables which plagues the Hybrid Molecular-dynamics (HMD) method. The RHMC algorithm uses rational approximations to fractional powers of the quadratic Dirac operator. Such approximations are only available when positive upper and lower bounds to the operator’s spectrum are known. We apply the RHMC algorithm to simulations of 2 theories for which a positive lower spectral bound is unknown: lattice QCD with staggered quarks at finite isospin chemical potential and lattice QCD with massless staggered quarks and chiral 4-fermion interactions (χQCD). A choice of lower bound is made in each case, and the properties of the RHMC simulations these define are studied. Justification of our choices of lower bounds is made by comparing measurements with those from HMD simulations, and by comparing different choices of lower bounds.

  14. CAD-based Monte Carlo Program for Integrated Simulation of Nuclear System SuperMC

    NASA Astrophysics Data System (ADS)

    Wu, Yican; Song, Jing; Zheng, Huaqing; Sun, Guangyao; Hao, Lijuan; Long, Pengcheng; Hu, Liqin

    2014-06-01

    Monte Carlo (MC) method has distinct advantages to simulate complicated nuclear systems and is envisioned as routine method for nuclear design and analysis in the future. High fidelity simulation with MC method coupled with multi-physical phenomenon simulation has significant impact on safety, economy and sustainability of nuclear systems. However, great challenges to current MC methods and codes prevent its application in real engineering project. SuperMC is a CAD-based Monte Carlo program for integrated simulation of nuclear system developed by FDS Team, China, making use of hybrid MC-deterministic method and advanced computer technologies. The design aim, architecture and main methodology of SuperMC were presented in this paper. SuperMC2.1, the latest version for neutron, photon and coupled neutron and photon transport calculation, has been developed and validated by using a series of benchmarking cases such as the fusion reactor ITER model and the fast reactor BN-600 model. SuperMC is still in its evolution process toward a general and routine tool for nuclear system. Warning, no authors found for 2014snam.conf06023.

  15. Empirical Analysis of Stochastic Volatility Model by Hybrid Monte Carlo Algorithm

    NASA Astrophysics Data System (ADS)

    Takaishi, Tetsuya

    2013-04-01

    The stochastic volatility model is one of volatility models which infer latent volatility of asset returns. The Bayesian inference of the stochastic volatility (SV) model is performed by the hybrid Monte Carlo (HMC) algorithm which is superior to other Markov Chain Monte Carlo methods in sampling volatility variables. We perform the HMC simulations of the SV model for two liquid stock returns traded on the Tokyo Stock Exchange and measure the volatilities of those stock returns. Then we calculate the accuracy of the volatility measurement using the realized volatility as a proxy of the true volatility and compare the SV model with the GARCH model which is one of other volatility models. Using the accuracy calculated with the realized volatility we find that empirically the SV model performs better than the GARCH model.

  16. A hybrid transport-diffusion method for Monte Carlo radiative-transfer simulations

    SciTech Connect

    Densmore, Jeffery D. . E-mail: jdd@lanl.gov; Urbatsch, Todd J. . E-mail: tmonster@lanl.gov; Evans, Thomas M. . E-mail: tme@lanl.gov; Buksas, Michael W. . E-mail: mwbuksas@lanl.gov

    2007-03-20

    Discrete Diffusion Monte Carlo (DDMC) is a technique for increasing the efficiency of Monte Carlo particle-transport simulations in diffusive media. If standard Monte Carlo is used in such media, particle histories will consist of many small steps, resulting in a computationally expensive calculation. In DDMC, particles take discrete steps between spatial cells according to a discretized diffusion equation. Each discrete step replaces many small Monte Carlo steps, thus increasing the efficiency of the simulation. In addition, given that DDMC is based on a diffusion equation, it should produce accurate solutions if used judiciously. In practice, DDMC is combined with standard Monte Carlo to form a hybrid transport-diffusion method that can accurately simulate problems with both diffusive and non-diffusive regions. In this paper, we extend previously developed DDMC techniques in several ways that improve the accuracy and utility of DDMC for nonlinear, time-dependent, radiative-transfer calculations. The use of DDMC in these types of problems is advantageous since, due to the underlying linearizations, optically thick regions appear to be diffusive. First, we employ a diffusion equation that is discretized in space but is continuous in time. Not only is this methodology theoretically more accurate than temporally discretized DDMC techniques, but it also has the benefit that a particle's time is always known. Thus, there is no ambiguity regarding what time to assign a particle that leaves an optically thick region (where DDMC is used) and begins transporting by standard Monte Carlo in an optically thin region. Also, we treat the interface between optically thick and optically thin regions with an improved method, based on the asymptotic diffusion-limit boundary condition, that can produce accurate results regardless of the angular distribution of the incident Monte Carlo particles. Finally, we develop a technique for estimating radiation momentum deposition during the DDMC simulation, a quantity that is required to calculate correct fluid motion in coupled radiation-hydrodynamics problems. With a set of numerical examples, we demonstrate that our improved DDMC method is accurate and can provide efficiency gains of several orders of magnitude over standard Monte Carlo.

  17. High order Chin actions in path integral Monte Carlo

    SciTech Connect

    Sakkos, K.; Casulleras, J.; Boronat, J.

    2009-05-28

    High order actions proposed by Chin have been used for the first time in path integral Monte Carlo simulations. Contrary to the Takahashi-Imada action, which is accurate to the fourth order only for the trace, the Chin action is fully fourth order, with the additional advantage that the leading fourth-order error coefficients are finely tunable. By optimizing two free parameters entering in the new action, we show that the time step error dependence achieved is best fitted with a sixth order law. The computational effort per bead is increased but the total number of beads is greatly reduced and the efficiency improvement with respect to the primitive approximation is approximately a factor of 10. The Chin action is tested in a one-dimensional harmonic oscillator, a H{sub 2} drop, and bulk liquid {sup 4}He. In all cases a sixth-order law is obtained with values of the number of beads that compare well with the pair action approximation in the stringent test of superfluid {sup 4}He.

  18. Hybrid laser integration for silicon photonics platform

    NASA Astrophysics Data System (ADS)

    Yang, Shuyu

    Silicon photonics has attracted extensive attention in both academia and industry in recent years, as an enabling technology to address the exponentially increasing demands for communication bandwidth. It brings state-of-the-art complementary metal-oxide-semiconductor (CMOS) processing technology to the field of photonic integration. The high yield and uniformity of silicon devices make it possible to build complex photonic systems-on-chip in large production volumes. Cutting-edge device performance has been demonstrated on this platform, including high-speed modulators, photodetectors, and passive devices such as the Y-junction, waveguide crossing, and arrayed waveguide gratings. As the device library quickly matures, an integrated laser source for a transmitter remains missing from the design kit. I demonstrated hybrid external cavity lasers by integrating reflective optical semiconductor amplifiers and silicon photonics chips. The gain chip and silicon chip can be designed and optimized independently, which is a significant advantage compared to bonding an III-V film on top of the silicon chip. Advanced optoelectronics packaging processes can be leveraged for chip alignment. Tunable C-Band (near 1550 nm) lasers with 10 mW on-chip power and less than 220 kHz bandwidth are demonstrated. O-Band lasers (operating near 1310 nm) as well as successful data transmission at 10 Gb/s and 40 Gb/s using the hybrid laser as the light source are also demonstrated. I designed a single cavity, multi wavelength laser by utilizing a quantum dot SOA, Sagnac loop and micro-ring based silicon photonics half cavity. Four lasing peaks with less than 3 dB power non-uniformity were measured, as well as 4 x 10 Gb/s error free data transmission. In addition to my main focus on RSOA/Silicon external cavity lasers, I propose and demonstrate a novel germanium-assisted grating coupler with low loss on-and-off chip fiber coupling. A coupling efficiency of 76% at 1.55 microm and 40 nm 1 dB optical bandwidth is achieved using FDTD simulation.

  19. A hybrid phase-space and histogram source model for GPU-based Monte Carlo radiotherapy dose calculation

    NASA Astrophysics Data System (ADS)

    Townson, Reid W.; Zavgorodni, Sergei

    2014-12-01

    In GPU-based Monte Carlo simulations for radiotherapy dose calculation, source modelling from a phase-space source can be an efficiency bottleneck. Previously, this has been addressed using phase-space-let (PSL) sources, which provided significant efficiency enhancement. We propose that additional speed-up can be achieved through the use of a hybrid primary photon point source model combined with a secondary PSL source. A novel phase-space derived and histogram-based implementation of this model has been integrated into gDPM v3.0. Additionally, a simple method for approximately deriving target photon source characteristics from a phase-space that does not contain inheritable particle history variables (LATCH) has been demonstrated to succeed in selecting over 99% of the true target photons with only ~0.3% contamination (for a Varian 21EX 18?MV machine). The hybrid source model was tested using an array of open fields for various Varian 21EX and TrueBeam energies, and all cases achieved greater than 97% chi-test agreement (the mean was 99%) above the 2% isodose with 1% / 1?mm criteria. The root mean square deviations (RMSDs) were less than 1%, with a mean of 0.5%, and the source generation time was 4-5 times faster. A seven-field intensity modulated radiation therapy patient treatment achieved 95% chi-test agreement above the 10% isodose with 1% / 1?mm criteria, 99.8% for 2% / 2?mm, a RMSD of 0.8%, and source generation speed-up factor of 2.5. Presented as part of the International Workshop on Monte Carlo Techniques in Medical Physics

  20. Using hybrid implicit Monte Carlo diffusion to simulate gray radiation hydrodynamics

    NASA Astrophysics Data System (ADS)

    Cleveland, Mathew A.; Gentile, Nick

    2015-06-01

    This work describes how to couple a hybrid Implicit Monte Carlo Diffusion (HIMCD) method with a Lagrangian hydrodynamics code to evaluate the coupled radiation hydrodynamics equations. This HIMCD method dynamically applies Implicit Monte Carlo Diffusion (IMD) [1] to regions of a problem that are opaque and diffusive while applying standard Implicit Monte Carlo (IMC) [2] to regions where the diffusion approximation is invalid. We show that this method significantly improves the computational efficiency as compared to a standard IMC/Hydrodynamics solver, when optically thick diffusive material is present, while maintaining accuracy. Two test cases are used to demonstrate the accuracy and performance of HIMCD as compared to IMC and IMD. The first is the Lowrie semi-analytic diffusive shock [3]. The second is a simple test case where the source radiation streams through optically thin material and heats a thick diffusive region of material causing it to rapidly expand. We found that HIMCD proves to be accurate, robust, and computationally efficient for these test problems.

  1. Using hybrid implicit Monte Carlo diffusion to simulate gray radiation hydrodynamics

    SciTech Connect

    Cleveland, Mathew A. Gentile, Nick

    2015-06-15

    This work describes how to couple a hybrid Implicit Monte Carlo Diffusion (HIMCD) method with a Lagrangian hydrodynamics code to evaluate the coupled radiation hydrodynamics equations. This HIMCD method dynamically applies Implicit Monte Carlo Diffusion (IMD) [1] to regions of a problem that are opaque and diffusive while applying standard Implicit Monte Carlo (IMC) [2] to regions where the diffusion approximation is invalid. We show that this method significantly improves the computational efficiency as compared to a standard IMC/Hydrodynamics solver, when optically thick diffusive material is present, while maintaining accuracy. Two test cases are used to demonstrate the accuracy and performance of HIMCD as compared to IMC and IMD. The first is the Lowrie semi-analytic diffusive shock [3]. The second is a simple test case where the source radiation streams through optically thin material and heats a thick diffusive region of material causing it to rapidly expand. We found that HIMCD proves to be accurate, robust, and computationally efficient for these test problems.

  2. Automatic mesh adaptivity for hybrid Monte Carlo/deterministic neutronics modeling of difficult shielding problems

    DOE PAGESBeta

    Ibrahim, Ahmad M.; Wilson, Paul P.H.; Sawan, Mohamed E.; Mosher, Scott W.; Peplow, Douglas E.; Wagner, John C.; Evans, Thomas M.; Grove, Robert E.

    2015-06-30

    The CADIS and FW-CADIS hybrid Monte Carlo/deterministic techniques dramatically increase the efficiency of neutronics modeling, but their use in the accurate design analysis of very large and geometrically complex nuclear systems has been limited by the large number of processors and memory requirements for their preliminary deterministic calculations and final Monte Carlo calculation. Three mesh adaptivity algorithms were developed to reduce the memory requirements of CADIS and FW-CADIS without sacrificing their efficiency improvement. First, a macromaterial approach enhances the fidelity of the deterministic models without changing the mesh. Second, a deterministic mesh refinement algorithm generates meshes that capture as muchmore » geometric detail as possible without exceeding a specified maximum number of mesh elements. Finally, a weight window coarsening algorithm decouples the weight window mesh and energy bins from the mesh and energy group structure of the deterministic calculations in order to remove the memory constraint of the weight window map from the deterministic mesh resolution. The three algorithms were used to enhance an FW-CADIS calculation of the prompt dose rate throughout the ITER experimental facility. Using these algorithms resulted in a 23.3% increase in the number of mesh tally elements in which the dose rates were calculated in a 10-day Monte Carlo calculation and, additionally, increased the efficiency of the Monte Carlo simulation by a factor of at least 3.4. The three algorithms enabled this difficult calculation to be accurately solved using an FW-CADIS simulation on a regular computer cluster, eliminating the need for a world-class super computer.« less

  3. Automatic mesh adaptivity for hybrid Monte Carlo/deterministic neutronics modeling of difficult shielding problems

    SciTech Connect

    Ibrahim, Ahmad M.; Wilson, Paul P.H.; Sawan, Mohamed E.; Mosher, Scott W.; Peplow, Douglas E.; Wagner, John C.; Evans, Thomas M.; Grove, Robert E.

    2015-06-30

    The CADIS and FW-CADIS hybrid Monte Carlo/deterministic techniques dramatically increase the efficiency of neutronics modeling, but their use in the accurate design analysis of very large and geometrically complex nuclear systems has been limited by the large number of processors and memory requirements for their preliminary deterministic calculations and final Monte Carlo calculation. Three mesh adaptivity algorithms were developed to reduce the memory requirements of CADIS and FW-CADIS without sacrificing their efficiency improvement. First, a macromaterial approach enhances the fidelity of the deterministic models without changing the mesh. Second, a deterministic mesh refinement algorithm generates meshes that capture as much geometric detail as possible without exceeding a specified maximum number of mesh elements. Finally, a weight window coarsening algorithm decouples the weight window mesh and energy bins from the mesh and energy group structure of the deterministic calculations in order to remove the memory constraint of the weight window map from the deterministic mesh resolution. The three algorithms were used to enhance an FW-CADIS calculation of the prompt dose rate throughout the ITER experimental facility. Using these algorithms resulted in a 23.3% increase in the number of mesh tally elements in which the dose rates were calculated in a 10-day Monte Carlo calculation and, additionally, increased the efficiency of the Monte Carlo simulation by a factor of at least 3.4. The three algorithms enabled this difficult calculation to be accurately solved using an FW-CADIS simulation on a regular computer cluster, eliminating the need for a world-class super computer.

  4. Hybrid Monte Carlo/Deterministic Methods for Accelerating Active Interrogation Modeling

    SciTech Connect

    Peplow, Douglas E.; Miller, Thomas Martin; Patton, Bruce W; Wagner, John C

    2013-01-01

    The potential for smuggling special nuclear material (SNM) into the United States is a major concern to homeland security, so federal agencies are investigating a variety of preventive measures, including detection and interdiction of SNM during transport. One approach for SNM detection, called active interrogation, uses a radiation source, such as a beam of neutrons or photons, to scan cargo containers and detect the products of induced fissions. In realistic cargo transport scenarios, the process of inducing and detecting fissions in SNM is difficult due to the presence of various and potentially thick materials between the radiation source and the SNM, and the practical limitations on radiation source strength and detection capabilities. Therefore, computer simulations are being used, along with experimental measurements, in efforts to design effective active interrogation detection systems. The computer simulations mostly consist of simulating radiation transport from the source to the detector region(s). Although the Monte Carlo method is predominantly used for these simulations, difficulties persist related to calculating statistically meaningful detector responses in practical computing times, thereby limiting their usefulness for design and evaluation of practical active interrogation systems. In previous work, the benefits of hybrid methods that use the results of approximate deterministic transport calculations to accelerate high-fidelity Monte Carlo simulations have been demonstrated for source-detector type problems. In this work, the hybrid methods are applied and evaluated for three example active interrogation problems. Additionally, a new approach is presented that uses multiple goal-based importance functions depending on a particle s relevance to the ultimate goal of the simulation. Results from the examples demonstrate that the application of hybrid methods to active interrogation problems dramatically increases their calculational efficiency.

  5. Generalized Metropolis acceptance criterion for hybrid non-equilibrium molecular dynamics—Monte Carlo simulations

    SciTech Connect

    Chen, Yunjie; Roux, Benoît

    2015-01-14

    A family of hybrid simulation methods that combines the advantages of Monte Carlo (MC) with the strengths of classical molecular dynamics (MD) consists in carrying out short non-equilibrium MD (neMD) trajectories to generate new configurations that are subsequently accepted or rejected via an MC process. In the simplest case where a deterministic dynamic propagator is used to generate the neMD trajectories, the familiar Metropolis acceptance criterion based on the change in the total energy ΔE, min[1,  exp( − βΔE)], guarantees that the hybrid algorithm will yield the equilibrium Boltzmann distribution. However, the functional form of the acceptance probability is more complex when the non-equilibrium switching process is generated via a non-deterministic stochastic dissipative propagator coupled to a heat bath. Here, we clarify the conditions under which the Metropolis criterion remains valid to rigorously yield a proper equilibrium Boltzmann distribution within hybrid neMD-MC algorithm.

  6. Lazy skip-lists: An algorithm for fast hybridization-expansion quantum Monte Carlo

    NASA Astrophysics Data System (ADS)

    Sémon, P.; Yee, Chuck-Hou; Haule, Kristjan; Tremblay, A.-M. S.

    2014-08-01

    The solution of a generalized impurity model lies at the heart of electronic structure calculations with dynamical mean field theory. In the strongly correlated regime, the method of choice for solving the impurity model is the hybridization-expansion continuous-time quantum Monte Carlo (CT-HYB). Enhancements to the CT-HYB algorithm are critical for bringing new physical regimes within reach of current computational power. Taking advantage of the fact that the bottleneck in the algorithm is a product of hundreds of matrices, we present optimizations based on the introduction and combination of two concepts of more general applicability: (a) skip lists and (b) fast rejection of proposed configurations based on matrix bounds. Considering two very different test cases with d electrons, we find speedups of ˜25 up to ˜500 compared to the direct evaluation of the matrix product. Even larger speedups are likely with f electron systems and with clusters of correlated atoms.

  7. HRMC: Hybrid Reverse Monte Carlo method with silicon and carbon potentials

    NASA Astrophysics Data System (ADS)

    Opletal, G.; Petersen, T. C.; O'Malley, B.; Snook, I. K.; McCulloch, D. G.; Yarovsky, I.

    2008-05-01

    Fortran 77 code is presented for a hybrid method of the Metropolis Monte Carlo (MMC) and Reverse Monte Carlo (RMC) for the simulation of amorphous silicon and carbon structures. In additional to the usual constraints of the pair correlation functions and average coordination, the code also incorporates an optional energy constraint. This energy constraint is in the form of either the Environment Dependent Interatomic Potential (applicable to silicon and carbon) and the original and modified Stillinger-Weber potentials (applicable to silicon). The code also allows porous systems to be modeled via a constraint on porosity and internal surface area using a novel restriction on the available simulation volume. Program summaryProgram title: HRMC version 1.0 Catalogue identifier: AEAO_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEAO_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 200 894 No. of bytes in distributed program, including test data, etc.: 907 557 Distribution format: tar.gz Programming language: FORTRAN 77 Computer: Any computer capable of running executables produced by the g77 Fortran compiler Operating system: Unix, Windows RAM: Depends on the type of empirical potential use, number of atoms and which constraints are employed Classification: 7.7 Nature of problem: Atomic modeling using empirical potentials and experimental data Solution method: Monte Carlo Additional comments: The code is not standard FORTRAN 77 but includes some additional features and therefore generates errors when compiled using the Nag95 compiler. It does compile successfully with the GNU g77 compiler ( http://www.gnu.org/software/fortran/fortran.html). Running time: Depends on the type of empirical potential use, number of atoms and which constraints are employed. The test included in the distribution took 37 minutes on a DEC Alpha PC.

  8. Hybrid Monte Carlo approach to the entanglement entropy of interacting fermions

    NASA Astrophysics Data System (ADS)

    Drut, Joaquín E.; Porter, William J.

    2015-09-01

    The Monte Carlo calculation of Rényi entanglement entropies Sn of interacting fermions suffers from a well-known signal-to-noise problem, even for a large number of situations in which the infamous sign problem is absent. A few methods have been proposed to overcome this issue, such as ensemble switching and the use of auxiliary partition-function ratios. Here, we present an approach that builds on the recently proposed free-fermion decomposition method; it incorporates entanglement in the probability measure in a natural way; it takes advantage of the hybrid Monte Carlo algorithm (an essential tool in lattice quantum chromodynamics and other gauge theories with dynamical fermions); and it does not suffer from noise problems. This method displays no sign problem for the same cases as other approaches and is therefore useful for a wide variety of systems. As a proof of principle, we calculate S2 for the one-dimensional, half-filled Hubbard model and compare with results from exact diagonalization and the free-fermion decomposition method.

  9. Feasibility of a Monte Carlo-deterministic hybrid method for fast reactor analysis

    SciTech Connect

    Heo, W.; Kim, W.; Kim, Y.; Yun, S.

    2013-07-01

    A Monte Carlo and deterministic hybrid method is investigated for the analysis of fast reactors in this paper. Effective multi-group cross sections data are generated using a collision estimator in the MCNP5. A high order Legendre scattering cross section data generation module was added into the MCNP5 code. Both cross section data generated from MCNP5 and TRANSX/TWODANT using the homogeneous core model were compared, and were applied to DIF3D code for fast reactor core analysis of a 300 MWe SFR TRU burner core. For this analysis, 9 groups macroscopic-wise data was used. In this paper, a hybrid calculation MCNP5/DIF3D was used to analyze the core model. The cross section data was generated using MCNP5. The k{sub eff} and core power distribution were calculated using the 54 triangle FDM code DIF3D. A whole core calculation of the heterogeneous core model using the MCNP5 was selected as a reference. In terms of the k{sub eff}, 9-group MCNP5/DIF3D has a discrepancy of -154 pcm from the reference solution, 9-group TRANSX/TWODANT/DIF3D analysis gives -1070 pcm discrepancy. (authors)

  10. Kinetic-MHD hybrid equilibrium model using a Monte-Carlo calculation of runaway electron distribution function

    NASA Astrophysics Data System (ADS)

    Matsuyama, Akinobu; Aiba, Nobuyuki; Yagi, Masatoshi

    2015-11-01

    An axisymmetric MHD equilibrium model is studied to allow the inclusion of both beam inertia and energy spectrum for runaway electron beam. Following kinetic-MHD hybrid approach, we evaluate the RE beam current from the integrals of the RE distribution function. The distribution function is here evaluated by a relativistic guiding-center trace code ETC-Rel, where we have implemented the effects of collisions, radiations, and exponential growth into the code. Because to directly treat the Dreicer mechanism in particle simulations is time consuming, the primary RE source is modeled by a Monte-Carlo weighing scheme taking into account the instantaneous generation rate. This paper applies ETC-Rel to the parametric study of the MHD equilibrium with different RE beam parameters. Kinetic effects on the MHD equilibrium appears, e.g., as enhanced Shafranov shifts due to the inertia of highly relativistic electrons. A kinetic modification to the equilibrium becomes significant if the contribution of the beam inertia - being increased with the total electron mass of multi-MeV RE populations - becomes large enough to affect the radial force balance. This work was supported in part by MEXT KAKENHI Grant No. 23561009 and 26820404.

  11. The integration of improved Monte Carlo compton scattering algorithms into the Integrated TIGER Series.

    SciTech Connect

    Quirk, Thomas, J., IV

    2004-08-01

    The Integrated TIGER Series (ITS) is a software package that solves coupled electron-photon transport problems. ITS performs analog photon tracking for energies between 1 keV and 1 GeV. Unlike its deterministic counterpart, the Monte Carlo calculations of ITS do not require a memory-intensive meshing of phase space; however, its solutions carry statistical variations. Reducing these variations is heavily dependent on runtime. Monte Carlo simulations must therefore be both physically accurate and computationally efficient. Compton scattering is the dominant photon interaction above 100 keV and below 5-10 MeV, with higher cutoffs occurring in lighter atoms. In its current model of Compton scattering, ITS corrects the differential Klein-Nishina cross sections (which assumes a stationary, free electron) with the incoherent scattering function, a function dependent on both the momentum transfer and the atomic number of the scattering medium. While this technique accounts for binding effects on the scattering angle, it excludes the Doppler broadening the Compton line undergoes because of the momentum distribution in each bound state. To correct for these effects, Ribbefor's relativistic impulse approximation (IA) will be employed to create scattering cross section differential in both energy and angle for each element. Using the parameterizations suggested by Brusa et al., scattered photon energies and angle can be accurately sampled at a high efficiency with minimal physical data. Two-body kinematics then dictates the electron's scattered direction and energy. Finally, the atomic ionization is relaxed via Auger emission or fluorescence. Future work will extend these improvements in incoherent scattering to compounds and to adjoint calculations.

  12. High-order path-integral Monte Carlo methods for solving quantum dot problems

    NASA Astrophysics Data System (ADS)

    Chin, Siu A.

    2015-03-01

    The conventional second-order path-integral Monte Carlo method is plagued with the sign problem in solving many-fermion systems. This is due to the large number of antisymmetric free-fermion propagators that are needed to extract the ground state wave function at large imaginary time. In this work we show that optimized fourth-order path-integral Monte Carlo methods, which use no more than five free-fermion propagators, can yield accurate quantum dot energies for up to 20 polarized electrons with the use of the Hamiltonian energy estimator.

  13. New hybrid voxelized/analytical primitive in Monte Carlo simulations for medical applications.

    PubMed

    Bert, Julien; Lemaréchal, Yannick; Visvikis, Dimitris

    2016-05-01

    Monte Carlo simulations (MCS) applied in particle physics play a key role in medical imaging and particle therapy. In such simulations, particles are transported through voxelized phantoms derived from predominantly patient CT images. However, such voxelized object representation limits the incorporation of fine elements, such as artificial implants from CAD modeling or anatomical and functional details extracted from other imaging modalities. In this work we propose a new hYbrid Voxelized/ANalytical primitive (YVAN) that combines both voxelized and analytical object descriptions within the same MCS, without the need to simultaneously run two parallel simulations, which is the current gold standard methodology. Given that YVAN is simply a new primitive object, it does not require any modifications on the underlying MC navigation code. The new proposed primitive was assessed through a first simple MCS. Results from the YVAN primitive were compared against an MCS using a pure analytical geometry and the layer mass geometry concept. A perfect agreement was found between these simulations, leading to the conclusion that the new hybrid primitive is able to accurately and efficiently handle phantoms defined by a mixture of voxelized and analytical objects. In addition, two application-based evaluation studies in coronary angiography and intra-operative radiotherapy showed that the use of YVAN was 6.5% and 12.2% faster than the layered mass geometry method, respectively, without any associated loss of accuracy. However, the simplification advantages and differences in computational time improvements obtained with YVAN depend on the relative proportion of the analytical and voxelized structures used in the simulation as well as the size and number of triangles used in the description of the analytical object meshes. PMID:27032813

  14. New hybrid voxelized/analytical primitive in Monte Carlo simulations for medical applications

    NASA Astrophysics Data System (ADS)

    Bert, Julien; Lemaréchal, Yannick; Visvikis, Dimitris

    2016-05-01

    Monte Carlo simulations (MCS) applied in particle physics play a key role in medical imaging and particle therapy. In such simulations, particles are transported through voxelized phantoms derived from predominantly patient CT images. However, such voxelized object representation limits the incorporation of fine elements, such as artificial implants from CAD modeling or anatomical and functional details extracted from other imaging modalities. In this work we propose a new hYbrid Voxelized/ANalytical primitive (YVAN) that combines both voxelized and analytical object descriptions within the same MCS, without the need to simultaneously run two parallel simulations, which is the current gold standard methodology. Given that YVAN is simply a new primitive object, it does not require any modifications on the underlying MC navigation code. The new proposed primitive was assessed through a first simple MCS. Results from the YVAN primitive were compared against an MCS using a pure analytical geometry and the layer mass geometry concept. A perfect agreement was found between these simulations, leading to the conclusion that the new hybrid primitive is able to accurately and efficiently handle phantoms defined by a mixture of voxelized and analytical objects. In addition, two application-based evaluation studies in coronary angiography and intra-operative radiotherapy showed that the use of YVAN was 6.5% and 12.2% faster than the layered mass geometry method, respectively, without any associated loss of accuracy. However, the simplification advantages and differences in computational time improvements obtained with YVAN depend on the relative proportion of the analytical and voxelized structures used in the simulation as well as the size and number of triangles used in the description of the analytical object meshes.

  15. Optimized molecular reconstruction procedure combining hybrid reverse Monte Carlo and molecular dynamics

    SciTech Connect

    Bousige, Colin; Boţan, Alexandru; Coasne, Benoît; Ulm, Franz-Josef; Pellenq, Roland J.-M.

    2015-03-21

    We report an efficient atom-scale reconstruction method that consists of combining the Hybrid Reverse Monte Carlo algorithm (HRMC) with Molecular Dynamics (MD) in the framework of a simulated annealing technique. In the spirit of the experimentally constrained molecular relaxation technique [Biswas et al., Phys. Rev. B 69, 195207 (2004)], this modified procedure offers a refined strategy in the field of reconstruction techniques, with special interest for heterogeneous and disordered solids such as amorphous porous materials. While the HRMC method generates physical structures, thanks to the use of energy penalties, the combination with MD makes the method at least one order of magnitude faster than HRMC simulations to obtain structures of similar quality. Furthermore, in order to ensure the transferability of this technique, we provide rational arguments to select the various input parameters such as the relative weight ω of the energy penalty with respect to the structure optimization. By applying the method to disordered porous carbons, we show that adsorption properties provide data to test the global texture of the reconstructed sample but are only weakly sensitive to the presence of defects. In contrast, the vibrational properties such as the phonon density of states are found to be very sensitive to the local structure of the sample.

  16. Development of Subspace-based Hybrid Monte Carlo-Deterministric Algorithms for Reactor Physics Calculations

    SciTech Connect

    Abdel-Khalik, Hany S.; Zhang, Qiong

    2014-05-20

    The development of hybrid Monte-Carlo-Deterministic (MC-DT) approaches, taking place over the past few decades, have primarily focused on shielding and detection applications where the analysis requires a small number of responses, i.e. at the detector locations(s). This work further develops a recently introduced global variance reduction approach, denoted by the SUBSPACE approach is designed to allow the use of MC simulation, currently limited to benchmarking calculations, for routine engineering calculations. By way of demonstration, the SUBSPACE approach is applied to assembly level calculations used to generate the few-group homogenized cross-sections. These models are typically expensive and need to be executed in the order of 103 - 105 times to properly characterize the few-group cross-sections for downstream core-wide calculations. Applicability to k-eigenvalue core-wide models is also demonstrated in this work. Given the favorable results obtained in this work, we believe the applicability of the MC method for reactor analysis calculations could be realized in the near future.

  17. Neutral depletion in inductively coupled plasmas using hybrid-type direct simulation Monte Carlo

    SciTech Connect

    Shimada, Masashi; Tynan, George R.; Cattolica, Robert

    2008-02-01

    Neutral and ion transport phenomena were simulated by a hybrid-type direct simulation Monte Carlo (DSMC) method for a one-dimensional (1D) electrostatic plasma in Ar/N{sub 2} mixtures to identify the mechanism of neutral depletion. The results show that gas heating and pressure balance are the main mechanisms of neutral depletion in an inductively coupled plasma. When plasma pressure becomes comparable to neutral pressure in high density plasma sources (T{sub e}{approx}2-5 eV, n{sub e}{approx}10{sup 11}-10{sup 12} cm{sup -3}), the total pressure (neutral pressure and plasma pressure) is conserved. Therefore, the finite plasma pressure (mainly electron pressure) reduces the neutral pressure. Neutrals collide with ions that have been accelerated by the ambipolar electric field and with Franck-Condon dissociated atoms, resulting in gas heating. Significant neutral depletion (up to 90%) is found at the typical condition of inductively coupled plasma process reactors. The resulting neutral depletion enhances the plasma transport to the surrounding wall, increases the particle loss, and decreases the plasma density.

  18. HRMC_2.1: Hybrid Reverse Monte Carlo method with silicon, carbon, germanium and silicon carbide potentials

    NASA Astrophysics Data System (ADS)

    Opletal, G.; Petersen, T. C.; Russo, S. P.

    2014-06-01

    The Hybrid Reverse Monte Carlo (HRMC) code models the atomic structure of materials via the use of a combination of constraints including experimental diffraction data and an empirical energy potential. In this version 2.1 update, an empirical potential for silicon-carbide has been added to the code along with an experimentally motivated constraint on the bond type fraction applicable to systems containing multiple elements.

  19. Hybrid III-V/silicon SOA for photonic integrated circuits

    NASA Astrophysics Data System (ADS)

    Kaspar, P.; Brenot, R.; Le Liepvre, A.; Accard, A.; Make, D.; Levaufre, G.; Girard, N.; Lelarge, F.; Duan, G.-H.; Olivier, S.; Jany, Christophe; Kopp, C.; Menezo, S.

    2014-11-01

    Silicon photonics has reached a considerable level of maturity, and the complexity of photonic integrated circuits (PIC) is steadily increasing. As the number of components in a PIC grows, loss management becomes more and more important. Integrated semiconductor optical amplifiers (SOA) will be crucial components in future photonic systems for loss compensation. In addition, there are specific applications, where SOAs can play a key role beyond mere loss compensation, such as modulated reflective SOAs in carrier distributed passive optical networks or optical gates in packet switching. It is, therefore, highly desirable to find a generic integration platform that includes the possibility of integrating SOAs on silicon. Various methods are currently being developed to integrate light emitters on silicon-on-insulator (SOI) waveguide circuits. Many of them use III-V materials for the hybrid integration on SOI. Various types of lasers have been demonstrated by several groups around the globe. In some of the integration approaches, SOAs can be implemented using essentially the same technology as for lasers. In this paper we will focus on SOA devices based on a hybrid integration approach where III-V material is bonded on SOI and a vertical optical mode transfer is used to couple light between SOI waveguides and guides formed in bonded III-V semiconductor layers. In contrast to evanescent coupling schemes, this mode transfer allows for a higher confinement factor in the gain material and thus for efficient light amplification over short propagation distances. We will outline the fabrication process of our hybrid components and present some of the most interesting results from a fabricated and packaged hybrid SOA.

  20. Fully integrated hybrid silicon two dimensional beam scanner.

    PubMed

    Hulme, J C; Doylend, J K; Heck, M J R; Peters, J D; Davenport, M L; Bovington, J T; Coldren, L A; Bowers, J E

    2015-03-01

    In this work we present the first fully-integrated free-space beam-steering chip using the hybrid silicon platform. The photonic integrated circuit (PIC) consists of 164 optical components including lasers, amplifiers, photodiodes, phase tuners, grating couplers, splitters, and a photonic crystal lens. The PIC exhibited steering over 23° x 3.6° with beam widths of 1° x 0.6°. PMID:25836813

  1. HRMC_1.1: Hybrid Reverse Monte Carlo method with silicon and carbon potentials

    NASA Astrophysics Data System (ADS)

    Opletal, G.; Petersen, T. C.; O'Malley, B.; Snook, I. K.; McCulloch, D. G.; Yarovsky, I.

    2011-02-01

    The Hybrid Reverse Monte Carlo (HRMC) code models the atomic structure of materials via the use of a combination of constraints including experimental diffraction data and an empirical energy potential. This energy constraint is in the form of either the Environment Dependent Interatomic Potential (EDIP) for carbon and silicon and the original and modified Stillinger-Weber potentials applicable to silicon. In this version, an update is made to correct an error in the EDIP carbon energy calculation routine. New version program summaryProgram title: HRMC version 1.1 Catalogue identifier: AEAO_v1_1 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEAO_v1_1.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 36 991 No. of bytes in distributed program, including test data, etc.: 907 800 Distribution format: tar.gz Programming language: FORTRAN 77 Computer: Any computer capable of running executables produced by the g77 Fortran compiler. Operating system: Unix, Windows RAM: Depends on the type of empirical potential use, number of atoms and which constraints are employed. Classification: 7.7 Catalogue identifier of previous version: AEAO_v1_0 Journal reference of previous version: Comput. Phys. Comm. 178 (2008) 777 Does the new version supersede the previous version?: Yes Nature of problem: Atomic modelling using empirical potentials and experimental data. Solution method: Monte Carlo Reasons for new version: An error in a term associated with the calculation of energies using the EDIP carbon potential which results in incorrect energies. Summary of revisions: Fix to correct brackets in the two body part of the EDIP carbon potential routine. Additional comments: The code is not standard FORTRAN 77 but includes some additional features and therefore generates errors when compiled using the Nag95 compiler. It does compile successfully with the GNU g77 compiler ( http://www.gnu.org/software/fortran/fortran.html). Running time: Depends on the type of empirical potential use, number of atoms and which constraints are employed. The test included in the distribution took 37 minutes on a DEC Alpha PC.

  2. Integrated Hybrid System Architecture for Risk Analysis

    NASA Technical Reports Server (NTRS)

    Moynihan, Gary P.; Fonseca, Daniel J.; Ray, Paul S.

    2010-01-01

    A conceptual design has been announced of an expert-system computer program, and the development of a prototype of the program, intended for use as a project-management tool. The program integrates schedule and risk data for the purpose of determining the schedule applications of safety risks and, somewhat conversely, the effects of changes in schedules on changes on safety. It is noted that the design has been delivered to a NASA client and that it is planned to disclose the design in a conference presentation.

  3. An Integrated Hybrid Transportation Architecture for Human Mars Expeditions

    NASA Technical Reports Server (NTRS)

    Merrill, Raymond G.; Chai, Patrick R.; Qu, Min

    2015-01-01

    NASA's Human Spaceflight Architecture Team is developing a reusable hybrid transportation architecture that uses both chemical and electric propulsion systems on the same vehicle to send crew and cargo to Mars destinations such as Phobos, Deimos, the surface of Mars, and other orbits around Mars. By applying chemical and electrical propulsion where each is most effective, the hybrid architecture enables a series of Mars trajectories that are more fuel-efficient than an all chemical architecture without significant increases in flight times. This paper presents an integrated Hybrid in-space transportation architecture for piloted missions and delivery of cargo. A concept for a Mars campaign including orbital and Mars surface missions is described in detail including a system concept of operations and conceptual design. Specific constraints, margin, and pinch points are identified for the architecture and opportunities for critical path commercial and international collaboration are discussed.

  4. A two-dimensional simulation of the GEC RF reference cell using a hybrid fluid-Monte Carlo method

    SciTech Connect

    Pak, H.; Riley, M.E.

    1992-12-01

    A two-dimensional fluid-Monte Carlo hybrid model is used to simulate the GEC reference cell. The 2-D model assumes azimuthal symmetry and accounts for the ground shield about the electrodes as well as the grounded chamber walls. The hybrid model consists of a Monte Carlo method for generating rates and a fluid model for transporting electrons and ions. In the fluid model, the electrons are transported using the continuity equation; and the electric fields are solved self-consistently using Poisson`s equation. The Monte Carlo model transports electrons using the fluid-generated periodic electric field. The ionization rates are then obtained using the electron energy distribution function. An averaging method is used to speed the solution by transporting the ions in a time-averaged electric field with a corrected ambipolar-type diffusion. The simulation switches between the conventional and the averaging fluid model. Typically, the simulation runs from 10`s to 100`s of averaging fluid cycles before reentering the conventional fluid model for 10`s of cycles. Speed increases of a factor of 100 are possible.

  5. Polymer waveguide based hybrid opto-electric integration technology

    NASA Astrophysics Data System (ADS)

    Mao, Jinbin; Deng, Lingling; Jiang, Xiyan; Ren, Rong; Zhai, Yumeng; Wang, Jin

    2014-10-01

    While monolithic integration especially based on InP appears to be quite an expensive solution for optical devices, hybrid integration solutions using cheaper material platforms are considered powerful competitors because of the high freedom of design, yield optimization and relative cost-efficiency. Among them, the polymer planar-lightwave circuit (PLC) technology is regarded attractive as polymer offers the potential of fairly simple and low-cost fabrication, and of low-cost packaging. In our work, polymer PLC was fabricated by using the standard reactive ion etching (RIE) technique, while other active and passive devices can be integrated on the polymer PLC platform. Exemplary polymer waveguide devices was a 13-channel arrayed waveguide grating (AWG) chip, where the central channel cross-talk was below -30dB and the polarization dependent frequency shift was mitigated by inserting a half wave plate. An optical 900 hybrid was also realized with one 2×4 multi-mode interferometer (MMI). The excess insertion losses are below 4dB for the C-band, while the transmission imbalance is below 1.2dB. When such an optical hybrid was integrated vertically with mesa-type photodiodes, the responsivity of the individual PD was around 0.06 A/W, while the 3 dB bandwidth reaches 24 ~ 27 GHz, which is sufficient for 100Gbit/s receivers. Another example of the hybrid integration was to couple the polymer waveguides to fiber by applying fiber grooves, whose typical loss value was 0.2 dB per-facet over a broad spectral range from 1200-1600 nm.

  6. SU-E-T-117: Dose to Organs Outside of CT Scan Range- Monte Carlo and Hybrid Phantom Approach

    SciTech Connect

    Pelletier, C; Jung, J; Lee, C; Kim, J; Lee, C

    2014-06-01

    Purpose: Epidemiological study of second cancer risk for cancer survivors often requires the dose to normal tissues located outside the anatomy covered by radiological imaging, which is usually limited to tumor and organs at risk. We have investigated the feasibility of using whole body computational human phantoms for estimating out-of-field organ doses for patients treated by Intensity Modulated Radiation Therapy (IMRT). Methods: Identical 7-field IMRT prostate plans were performed using X-ray Voxel Monte Carlo (XVMC), a radiotherapy-specific Monte Carlo transport code, on the computed tomography (CT) images of the torso of an adult male patient (175 cm height, 66 kg weight) and an adult male hybrid computational phantom with the equivalent body size. Dose to the liver, right lung, and left lung were calculated and compared. Results: Considerable differences are seen between the doses calculated by XVMC for the patient CT and the hybrid phantom. One major contributing factor is the treatment method, deep inspiration breath hold (DIBH), used for this patient. This leads to significant differences in the organ position relative to the treatment isocenter. The transverse distances from the treatment isocenter to the inferior border of the liver, left lung, and right lung are 19.5cm, 29.5cm, and 30.0cm, respectively for the patient CT, compared with 24.3cm, 36.6cm, and 39.1cm, respectively, for the hybrid phantom. When corrected for the distance, the mean doses calculated using the hybrid phantom are within 28% of those calculated using the patient CT. Conclusion: This study showed that mean dose to the organs located in the missing CT coverage can be reconstructed by using whole body computational human phantoms within reasonable dosimetric uncertainty, however appropriate corrections may be necessary if the patient is treated with a technique that will significantly deform the size or location of the organs relative to the hybrid phantom.

  7. ACCELERATING FUSION REACTOR NEUTRONICS MODELING BY AUTOMATIC COUPLING OF HYBRID MONTE CARLO/DETERMINISTIC TRANSPORT ON CAD GEOMETRY

    SciTech Connect

    Biondo, Elliott D; Ibrahim, Ahmad M; Mosher, Scott W; Grove, Robert E

    2015-01-01

    Detailed radiation transport calculations are necessary for many aspects of the design of fusion energy systems (FES) such as ensuring occupational safety, assessing the activation of system components for waste disposal, and maintaining cryogenic temperatures within superconducting magnets. Hybrid Monte Carlo (MC)/deterministic techniques are necessary for this analysis because FES are large, heavily shielded, and contain streaming paths that can only be resolved with MC. The tremendous complexity of FES necessitates the use of CAD geometry for design and analysis. Previous ITER analysis has required the translation of CAD geometry to MCNP5 form in order to use the AutomateD VAriaNce reducTion Generator (ADVANTG) for hybrid MC/deterministic transport. In this work, ADVANTG was modified to support CAD geometry, allowing hybrid (MC)/deterministic transport to be done automatically and eliminating the need for this translation step. This was done by adding a new ray tracing routine to ADVANTG for CAD geometries using the Direct Accelerated Geometry Monte Carlo (DAGMC) software library. This new capability is demonstrated with a prompt dose rate calculation for an ITER computational benchmark problem using both the Consistent Adjoint Driven Importance Sampling (CADIS) method an the Forward Weighted (FW)-CADIS method. The variance reduction parameters produced by ADVANTG are shown to be the same using CAD geometry and standard MCNP5 geometry. Significant speedups were observed for both neutrons (as high as a factor of 7.1) and photons (as high as a factor of 59.6).

  8. The importance of hybrid PV-building integration

    SciTech Connect

    Posnansky, M.; Gnos, S.; Coonen, S.

    1994-12-31

    An extensive utilization of photovoltaics for future electricity generation and for hybrid generation of electricity and thermal energy is possible, when PV-panels are designed to become a part of the building envelope itself. Large areas are available, since roofs and facades are perfectly suited for solar energy conversion. Atlantis Energy Ltd. has developed special PV-generators which fulfill at the same time the functions and requirements of conventional building elements. In the context of different R and D projects funded by the Swiss government to implement a series of typical building integrated photovoltaic systems, Atlantis Energy Ltd was entrusted to design and build various hybrid building integrated PV-power plants, four of which are described in this paper.

  9. High-order Path Integral Monte Carlo methods for solving strongly correlated fermion problems

    NASA Astrophysics Data System (ADS)

    Chin, Siu A.

    2015-03-01

    In solving for the ground state of a strongly correlated many-fermion system, the conventional second-order Path Integral Monte Carlo method is plagued with the sign problem. This is due to the large number of anti-symmetric free fermion propagators that are needed to extract the square of the ground state wave function at large imaginary time. In this work, I show that optimized fourth-order Path Integral Monte Carlo methods, which uses no more than 5 free-fermion propagators, in conjunction with the use of the Hamiltonian energy estimator, can yield accurate ground state energies for quantum dots with up to 20 polarized electrons. The correlations are directly built-in and no explicit wave functions are needed. This work is supported by the Qatar National Research Fund NPRP GRANT #5-674-1-114.

  10. Worm Algorithm for Continuous-Space Path Integral Monte Carlo Simulations

    SciTech Connect

    Boninsegni, Massimo; Prokof'ev, Nikolay; Svistunov, Boris

    2006-02-24

    We present a new approach to path integral Monte Carlo (PIMC) simulations based on the worm algorithm, originally developed for lattice models and extended here to continuous-space many-body systems. The scheme allows for efficient computation of thermodynamic properties, including winding numbers and off-diagonal correlations, for systems of much greater size than that accessible to conventional PIMC simulations. As an illustrative application of the method, we simulate the superfluid transition of {sup 4}He in two dimensions.

  11. Graphene/Si CMOS hybrid hall integrated circuits.

    PubMed

    Huang, Le; Xu, Huilong; Zhang, Zhiyong; Chen, Chengying; Jiang, Jianhua; Ma, Xiaomeng; Chen, Bingyan; Li, Zishen; Zhong, Hua; Peng, Lian-Mao

    2014-01-01

    Graphene/silicon CMOS hybrid integrated circuits (ICs) should provide powerful functions which combines the ultra-high carrier mobility of graphene and the sophisticated functions of silicon CMOS ICs. But it is difficult to integrate these two kinds of heterogeneous devices on a single chip. In this work a low temperature process is developed for integrating graphene devices onto silicon CMOS ICs for the first time, and a high performance graphene/CMOS hybrid Hall IC is demonstrated. Signal amplifying/process ICs are manufactured via commercial 0.18 um silicon CMOS technology, and graphene Hall elements (GHEs) are fabricated on top of the passivation layer of the CMOS chip via a low-temperature micro-fabrication process. The sensitivity of the GHE on CMOS chip is further improved by integrating the GHE with the CMOS amplifier on the Si chip. This work not only paves the way to fabricate graphene/Si CMOS Hall ICs with much higher performance than that of conventional Hall ICs, but also provides a general method for scalable integration of graphene devices with silicon CMOS ICs via a low-temperature process. PMID:24998222

  12. Graphene/Si CMOS Hybrid Hall Integrated Circuits

    NASA Astrophysics Data System (ADS)

    Huang, Le; Xu, Huilong; Zhang, Zhiyong; Chen, Chengying; Jiang, Jianhua; Ma, Xiaomeng; Chen, Bingyan; Li, Zishen; Zhong, Hua; Peng, Lian-Mao

    2014-07-01

    Graphene/silicon CMOS hybrid integrated circuits (ICs) should provide powerful functions which combines the ultra-high carrier mobility of graphene and the sophisticated functions of silicon CMOS ICs. But it is difficult to integrate these two kinds of heterogeneous devices on a single chip. In this work a low temperature process is developed for integrating graphene devices onto silicon CMOS ICs for the first time, and a high performance graphene/CMOS hybrid Hall IC is demonstrated. Signal amplifying/process ICs are manufactured via commercial 0.18 um silicon CMOS technology, and graphene Hall elements (GHEs) are fabricated on top of the passivation layer of the CMOS chip via a low-temperature micro-fabrication process. The sensitivity of the GHE on CMOS chip is further improved by integrating the GHE with the CMOS amplifier on the Si chip. This work not only paves the way to fabricate graphene/Si CMOS Hall ICs with much higher performance than that of conventional Hall ICs, but also provides a general method for scalable integration of graphene devices with silicon CMOS ICs via a low-temperature process.

  13. Graphene/Si CMOS Hybrid Hall Integrated Circuits

    PubMed Central

    Huang, Le; Xu, Huilong; Zhang, Zhiyong; Chen, Chengying; Jiang, Jianhua; Ma, Xiaomeng; Chen, Bingyan; Li, Zishen; Zhong, Hua; Peng, Lian-Mao

    2014-01-01

    Graphene/silicon CMOS hybrid integrated circuits (ICs) should provide powerful functions which combines the ultra-high carrier mobility of graphene and the sophisticated functions of silicon CMOS ICs. But it is difficult to integrate these two kinds of heterogeneous devices on a single chip. In this work a low temperature process is developed for integrating graphene devices onto silicon CMOS ICs for the first time, and a high performance graphene/CMOS hybrid Hall IC is demonstrated. Signal amplifying/process ICs are manufactured via commercial 0.18 um silicon CMOS technology, and graphene Hall elements (GHEs) are fabricated on top of the passivation layer of the CMOS chip via a low-temperature micro-fabrication process. The sensitivity of the GHE on CMOS chip is further improved by integrating the GHE with the CMOS amplifier on the Si chip. This work not only paves the way to fabricate graphene/Si CMOS Hall ICs with much higher performance than that of conventional Hall ICs, but also provides a general method for scalable integration of graphene devices with silicon CMOS ICs via a low-temperature process. PMID:24998222

  14. Novel integration technique for silicon/III-V hybrid laser.

    PubMed

    Dong, Po; Hu, Ting-Chen; Liow, Tsung-Yang; Chen, Young-Kai; Xie, Chongjin; Luo, Xianshu; Lo, Guo-Qiang; Kopf, Rose; Tate, Alaric

    2014-11-01

    Integrated semiconductor lasers on silicon are one of the most crucial devices to enable low-cost silicon photonic integrated circuits for high-bandwidth optic communications and interconnects. While optical amplifiers and lasers are typically realized in III-V waveguide structures, it is beneficial to have an integration approach which allows flexible and efficient coupling of light between III-V gain media and silicon waveguides. In this paper, we propose and demonstrate a novel fabrication technique and associated transition structure to realize integrated lasers without the constraints of other critical processing parameters such as the starting silicon layer thicknesses. This technique employs epitaxial growth of silicon in a pre-defined trench with taper structures. We fabricate and demonstrate a long-cavity hybrid laser with a narrow linewidth of 130 kHz and an output power of 1.5 mW using the proposed technique. PMID:25401832

  15. Worm algorithm and diagrammatic Monte Carlo: A new approach to continuous-space path integral Monte Carlo simulations

    SciTech Connect

    Boninsegni, M.; Prokof'ev, N. V.; Svistunov, B. V.

    2006-09-15

    A detailed description is provided of a new worm algorithm, enabling the accurate computation of thermodynamic properties of quantum many-body systems in continuous space, at finite temperature. The algorithm is formulated within the general path integral Monte Carlo (PIMC) scheme, but also allows one to perform quantum simulations in the grand canonical ensemble, as well as to compute off-diagonal imaginary-time correlation functions, such as the Matsubara Green function, simultaneously with diagonal observables. Another important innovation consists of the expansion of the attractive part of the pairwise potential energy into elementary (diagrammatic) contributions, which are then statistically sampled. This affords a complete microscopic account of the long-range part of the potential energy, while keeping the computational complexity of all updates independent of the size of the simulated system. The computational scheme allows for efficient calculations of the superfluid fraction and off-diagonal correlations in space-time, for system sizes which are orders of magnitude larger than those accessible to conventional PIMC. We present illustrative results for the superfluid transition in bulk liquid {sup 4}He in two and three dimensions, as well as the calculation of the chemical potential of hcp {sup 4}He.

  16. Permutation blocking path integral Monte Carlo approach to the uniform electron gas at finite temperature

    NASA Astrophysics Data System (ADS)

    Dornheim, Tobias; Schoof, Tim; Groth, Simon; Filinov, Alexey; Bonitz, Michael

    2015-11-01

    The uniform electron gas (UEG) at finite temperature is of high current interest due to its key relevance for many applications including dense plasmas and laser excited solids. In particular, density functional theory heavily relies on accurate thermodynamic data for the UEG. Until recently, the only existing first-principle results had been obtained for N = 33 electrons with restricted path integral Monte Carlo (RPIMC), for low to moderate density, r s = r ¯ / a B ≳ 1 . These data have been complemented by configuration path integral Monte Carlo (CPIMC) simulations for rs ≤ 1 that substantially deviate from RPIMC towards smaller rs and low temperature. In this work, we present results from an independent third method—the recently developed permutation blocking path integral Monte Carlo (PB-PIMC) approach [T. Dornheim et al., New J. Phys. 17, 073017 (2015)] which we extend to the UEG. Interestingly, PB-PIMC allows us to perform simulations over the entire density range down to half the Fermi temperature (θ = kBT/EF = 0.5) and, therefore, to compare our results to both aforementioned methods. While we find excellent agreement with CPIMC, where results are available, we observe deviations from RPIMC that are beyond the statistical errors and increase with density.

  17. Permutation blocking path integral Monte Carlo approach to the uniform electron gas at finite temperature.

    PubMed

    Dornheim, Tobias; Schoof, Tim; Groth, Simon; Filinov, Alexey; Bonitz, Michael

    2015-11-28

    The uniform electron gas (UEG) at finite temperature is of high current interest due to its key relevance for many applications including dense plasmas and laser excited solids. In particular, density functional theory heavily relies on accurate thermodynamic data for the UEG. Until recently, the only existing first-principle results had been obtained for N = 33 electrons with restricted path integral Monte Carlo (RPIMC), for low to moderate density, rs=r¯/aB≳1. These data have been complemented by configuration path integral Monte Carlo (CPIMC) simulations for rs ≤ 1 that substantially deviate from RPIMC towards smaller rs and low temperature. In this work, we present results from an independent third method-the recently developed permutation blocking path integral Monte Carlo (PB-PIMC) approach [T. Dornheim et al., New J. Phys. 17, 073017 (2015)] which we extend to the UEG. Interestingly, PB-PIMC allows us to perform simulations over the entire density range down to half the Fermi temperature (θ = kBT/EF = 0.5) and, therefore, to compare our results to both aforementioned methods. While we find excellent agreement with CPIMC, where results are available, we observe deviations from RPIMC that are beyond the statistical errors and increase with density. PMID:26627944

  18. First Results From GLAST-LAT Integrated Towers Cosmic Ray Data Taking And Monte Carlo Comparison

    SciTech Connect

    Brigida, M.; Caliandro, A.; Favuzzi, C.; Fusco, P.; Gargano, F.; Giordano, F.; Giglietto, N.; Loparco, F.; Marangelli, B.; Mazziotta, M.N.; Mirizzi, N.; Raino, S.; Spinelli, P.; /Bari U. /INFN, Bari

    2007-02-15

    GLAST Large Area Telescope (LAT) is a gamma ray telescope instrumented with silicon-strip detector planes and sheets of converter, followed by a calorimeter (CAL) and surrounded by an anticoincidence system (ACD). This instrument is sensitive to gamma rays in the energy range between 20 MeV and 300 GeV. At present, the first towers have been integrated and pre-launch data taking with cosmic ray muons is being performed. The results from the data analysis carried out during LAT integration will be discussed and a comparison with the predictions from the Monte Carlo simulation will be shown.

  19. Path integrals and large deviations in stochastic hybrid systems

    NASA Astrophysics Data System (ADS)

    Bressloff, Paul C.; Newby, Jay M.

    2014-04-01

    We construct a path-integral representation of solutions to a stochastic hybrid system, consisting of one or more continuous variables evolving according to a piecewise-deterministic dynamics. The differential equations for the continuous variables are coupled to a set of discrete variables that satisfy a continuous-time Markov process, which means that the differential equations are only valid between jumps in the discrete variables. Examples of stochastic hybrid systems arise in biophysical models of stochastic ion channels, motor-driven intracellular transport, gene networks, and stochastic neural networks. We use the path-integral representation to derive a large deviation action principle for a stochastic hybrid system. Minimizing the associated action functional with respect to the set of all trajectories emanating from a metastable state (assuming that such a minimization scheme exists) then determines the most probable paths of escape. Moreover, evaluating the action functional along a most probable path generates the so-called quasipotential used in the calculation of mean first passage times. We illustrate the theory by considering the optimal paths of escape from a metastable state in a bistable neural network.

  20. Hybrid silicon free-space source with integrated beam steering

    NASA Astrophysics Data System (ADS)

    Doylend, J. K.; Heck, M. J. R.; Bovington, J. T.; Peters, J. D.; Davenport, M. L.; Coldren, L. A.; Bowers, J. E.

    2013-02-01

    Free-space beam steering using optical phase arrays are desirable as a means of implementing Light Detection and Ranging (LIDAR) and free-space communication links without the need for moving parts, thus alleviating vulnerabilities due to vibrations and inertial forces. Implementing such an approach in silicon photonic integrated circuits is particularly desirable in order to take advantage of established CMOS processing techniques while reducing both device size and packaging complexity. In this work we demonstrate a free-space diode laser together with beam steering implemented on-chip in a silicon photonic circuit. A waveguide phased array, surface gratings, a hybrid III-V/silicon laser and an array of hybrid III/V silicon amplifiers were fabricated on-chip in order to achieve a fully integrated steerable free-space optical source with no external optical inputs, thus eliminating the need for fiber coupling altogether. The chip was fabricated using a modified version of the hybrid silicon process developed at UCSB, with modifications in order to incorporate diodes within the waveguide layer as well as within the III-V gain layer. Beam steering across a 12° field of view with +/-0.3° accuracy and 1.8°x0.6° beam width was achieved, with background peaks suppressed 7 dB relative to the main lobe within the field of view for arbitrarily chosen beam directions.

  1. Scalable Software for Multivariate Integration on Hybrid Platforms

    NASA Astrophysics Data System (ADS)

    de Doncker, E.; Yuasa, F.; Kapenga, J.; Olagbemi, O.

    2015-09-01

    The paper describes the software infrastructure of the PARINT package for multivariate numerical integration, layered over a hybrid parallel environment with distributed memory computations (on MPI). The parallel problem distribution is typically performed on the region level in the adaptive partitioning procedure. Our objective has been to provide the end-user with state of the art problem solving power packaged as portable software. We will give test results of the multivariate ParInt engine, with significant speedups for a set of 3-loop Feynman integrals. An extrapolation with respect to the dimensional regularization parameter (ε) is applied to sequences of multivariate ParInt results Q(ε) to obtain the leading asymptotic expansion coefficients as ε → 0. This paper further introduces a novel method for a parallel computation of the Q(ε) sequence as the components of the integral of a vector function.

  2. Two-dimensional hybrid Monte Carlo–fluid modelling of dc glow discharges: Comparison with fluid models, reliability, and accuracy

    SciTech Connect

    Eylenceoğlu, E.; Rafatov, I.; Kudryavtsev, A. A.

    2015-01-15

    Two-dimensional hybrid Monte Carlo–fluid numerical code is developed and applied to model the dc glow discharge. The model is based on the separation of electrons into two parts: the low energetic (slow) and high energetic (fast) electron groups. Ions and slow electrons are described within the fluid model using the drift-diffusion approximation for particle fluxes. Fast electrons, represented by suitable number of super particles emitted from the cathode, are responsible for ionization processes in the discharge volume, which are simulated by the Monte Carlo collision method. Electrostatic field is obtained from the solution of Poisson equation. The test calculations were carried out for an argon plasma. Main properties of the glow discharge are considered. Current-voltage curves, electric field reversal phenomenon, and the vortex current formation are developed and discussed. The results are compared to those obtained from the simple and extended fluid models. Contrary to reports in the literature, the analysis does not reveal significant advantages of existing hybrid methods over the extended fluid model.

  3. Quantum Mechanical Single Molecule Partition Function from PathIntegral Monte Carlo Simulations

    SciTech Connect

    Chempath, Shaji; Bell, Alexis T.; Predescu, Cristian

    2006-10-01

    An algorithm for calculating the partition function of a molecule with the path integral Monte Carlo method is presented. Staged thermodynamic perturbation with respect to a reference harmonic potential is utilized to evaluate the ratio of partition functions. Parallel tempering and a new Monte Carlo estimator for the ratio of partition functions are implemented here to achieve well converged simulations that give an accuracy of 0.04 kcal/mol in the reported free energies. The method is applied to various test systems, including a catalytic system composed of 18 atoms. Absolute free energies calculated by this method lead to corrections as large as 2.6 kcal/mol at 300 K for some of the examples presented.

  4. High Voltage Dielectrophoretic and Magnetophoretic Hybrid Integrated Circuit / Microfluidic Chip

    PubMed Central

    Issadore, David; Franke, Thomas; Brown, Keith A.; Hunt, Thomas P.; Westervelt, Robert M.

    2010-01-01

    A hybrid integrated circuit (IC) / microfluidic chip is presented that independently and simultaneously traps and moves microscopic objects suspended in fluid using both electric and magnetic fields. This hybrid chip controls the location of dielectric objects, such as living cells and drops of fluid, on a 60 × 61 array of pixels that are 30 × 38 μm2 in size, each of which can be individually addressed with a 50 V peak-to-peak, DC to 10 MHz radio frequency voltage. These high voltage pixels produce electric fields above the chip’s surface with a magnitude , resulting in strong dielectrophoresis (DEP) forces . Underneath the array of DEP pixels there is a magnetic matrix that consists of two perpendicular sets of 60 metal wires running across the chip. Each wire can be sourced with 120 mA to trap and move magnetically susceptible objects using magnetophoresis (MP). The DEP pixel array and magnetic matrix can be used simultaneously to apply forces to microscopic objects, such as living cells or lipid vesicles, that are tagged with magnetic nanoparticles. The capabilities of the hybrid IC / microfluidic chip demonstrated in this paper provide important building blocks for a platform for biological and chemical applications. PMID:20625468

  5. Hybrid two-chain simulation and integral equation theory : application to polyethylene liquids.

    SciTech Connect

    Huimin Li, David T. Wu; Curro, John G.; McCoy, John Dwane

    2006-02-01

    We present results from a hybrid simulation and integral equation approach to the calculation of polymer melt properties. The simulation consists of explicit Monte Carlo (MC) sampling of two polymer molecules, where the effect of the surrounding chains is accounted for by an HNC solvation potential. The solvation potential is determined from the Polymer Reference Interaction Site Model (PRISM) as a functional of the pair correlation function from simulation. This hybrid two-chain MC-PRISM approach was carried out on liquids of polyethylene chains of 24 and 66 CH{sub 2} units. The results are compared with MD simulation and self-consistent PRISM-PY theory under the same conditions, revealing that the two-chain calculation is close to MD, and able to overcome the defects of the PRISM-PY closure and predict more accurate structures of the liquid at both short and long range. The direct correlation function, for instance, has a tail at longer range which is consistent with MD simulation and avoids the short-range assumptions in PRISM-PY theory. As a result, the self-consistent two-chain MC-PRISM calculation predicts an isothermal compressibility closer to the MD results.

  6. Novel hybrid GPU-CPU implementation of parallelized Monte Carlo parametric expectation maximization estimation method for population pharmacokinetic data analysis.

    PubMed

    Ng, C M

    2013-10-01

    The development of a population PK/PD model, an essential component for model-based drug development, is both time- and labor-intensive. A graphical-processing unit (GPU) computing technology has been proposed and used to accelerate many scientific computations. The objective of this study was to develop a hybrid GPU-CPU implementation of parallelized Monte Carlo parametric expectation maximization (MCPEM) estimation algorithm for population PK data analysis. A hybrid GPU-CPU implementation of the MCPEM algorithm (MCPEMGPU) and identical algorithm that is designed for the single CPU (MCPEMCPU) were developed using MATLAB in a single computer equipped with dual Xeon 6-Core E5690 CPU and a NVIDIA Tesla C2070 GPU parallel computing card that contained 448 stream processors. Two different PK models with rich/sparse sampling design schemes were used to simulate population data in assessing the performance of MCPEMCPU and MCPEMGPU. Results were analyzed by comparing the parameter estimation and model computation times. Speedup factor was used to assess the relative benefit of parallelized MCPEMGPU over MCPEMCPU in shortening model computation time. The MCPEMGPU consistently achieved shorter computation time than the MCPEMCPU and can offer more than 48-fold speedup using a single GPU card. The novel hybrid GPU-CPU implementation of parallelized MCPEM algorithm developed in this study holds a great promise in serving as the core for the next-generation of modeling software for population PK/PD analysis. PMID:24002801

  7. The performance of a hybrid analytical-Monte Carlo system response matrix in pinhole SPECT reconstruction.

    PubMed

    El Bitar, Z; Pino, F; Candela, C; Ros, D; Pavía, J; Rannou, F R; Ruibal, A; Aguiar, P

    2014-12-21

    It is well-known that in pinhole SPECT (single-photon-emission computed tomography), iterative reconstruction methods including accurate estimations of the system response matrix can lead to submillimeter spatial resolution. There are two different methods for obtaining the system response matrix: those that model the system analytically using an approach including an experimental characterization of the detector response, and those that make use of Monte Carlo simulations. Methods based on analytical approaches are faster and handle the statistical noise better than those based on Monte Carlo simulations, but they require tedious experimental measurements of the detector response. One suggested approach for avoiding an experimental characterization, circumventing the problem of statistical noise introduced by Monte Carlo simulations, is to perform an analytical computation of the system response matrix combined with a Monte Carlo characterization of the detector response. Our findings showed that this approach can achieve high spatial resolution similar to that obtained when the system response matrix computation includes an experimental characterization. Furthermore, we have shown that using simulated detector responses has the advantage of yielding a precise estimate of the shift between the point of entry of the photon beam into the detector and the point of interaction inside the detector. Considering this, it was possible to slightly improve the spatial resolution in the edge of the field of view. PMID:25415206

  8. The performance of a hybrid analytical-Monte Carlo system response matrix in pinhole SPECT reconstruction

    NASA Astrophysics Data System (ADS)

    El Bitar, Z.; Pino, F.; Candela, C.; Ros, D.; Pavía, J.; Rannou, F. R.; Ruibal, A.; Aguiar, P.

    2014-12-01

    It is well-known that in pinhole SPECT (single-photon-emission computed tomography), iterative reconstruction methods including accurate estimations of the system response matrix can lead to submillimeter spatial resolution. There are two different methods for obtaining the system response matrix: those that model the system analytically using an approach including an experimental characterization of the detector response, and those that make use of Monte Carlo simulations. Methods based on analytical approaches are faster and handle the statistical noise better than those based on Monte Carlo simulations, but they require tedious experimental measurements of the detector response. One suggested approach for avoiding an experimental characterization, circumventing the problem of statistical noise introduced by Monte Carlo simulations, is to perform an analytical computation of the system response matrix combined with a Monte Carlo characterization of the detector response. Our findings showed that this approach can achieve high spatial resolution similar to that obtained when the system response matrix computation includes an experimental characterization. Furthermore, we have shown that using simulated detector responses has the advantage of yielding a precise estimate of the shift between the point of entry of the photon beam into the detector and the point of interaction inside the detector. Considering this, it was possible to slightly improve the spatial resolution in the edge of the field of view.

  9. Hybrid polymer photonic crystal fiber with integrated chalcogenide glass nanofilms.

    PubMed

    Markos, Christos; Kubat, Irnis; Bang, Ole

    2014-01-01

    The combination of chalcogenide glasses with polymer photonic crystal fibers (PCFs) is a difficult and challenging task due to their different thermo-mechanical material properties. Here we report the first experimental realization of a hybrid polymer-chalcogenide PCF with integrated As2S3 glass nanofilms at the inner surface of the air-channels of a poly-methyl-methacrylate (PMMA) PCF. The integrated high refractive index glass films introduce distinct antiresonant transmission bands in the 480-900 nm wavelength region. We demonstrate that the ultra-high Kerr nonlinearity of the chalcogenide glass makes the polymer PCF nonlinear and provides a possibility to shift the transmission band edges as much as 17 nm by changing the intensity. The proposed fabrication technique constitutes a new highway towards all-fiber nonlinear tunable devices based on polymer PCFs, which at the moment is not possible with any other fabrication method. PMID:25317501

  10. Golden Ratio Versus Pi as Random Sequence Sources for Monte Carlo Integration

    NASA Technical Reports Server (NTRS)

    Sen, S. K.; Agarwal, Ravi P.; Shaykhian, Gholam Ali

    2007-01-01

    We discuss here the relative merits of these numbers as possible random sequence sources. The quality of these sequences is not judged directly based on the outcome of all known tests for the randomness of a sequence. Instead, it is determined implicitly by the accuracy of the Monte Carlo integration in a statistical sense. Since our main motive of using a random sequence is to solve real world problems, it is more desirable if we compare the quality of the sequences based on their performances for these problems in terms of quality/accuracy of the output. We also compare these sources against those generated by a popular pseudo-random generator, viz., the Matlab rand and the quasi-random generator ha/ton both in terms of error and time complexity. Our study demonstrates that consecutive blocks of digits of each of these numbers produce a good random sequence source. It is observed that randomly chosen blocks of digits do not have any remarkable advantage over consecutive blocks for the accuracy of the Monte Carlo integration. Also, it reveals that pi is a better source of a random sequence than theta when the accuracy of the integration is concerned.

  11. Development of Path Integral Monte Carlo Simulations with Localized Nodal Surfaces for Second-Row Elements

    NASA Astrophysics Data System (ADS)

    Militzer, Burkhard; Driver, Kevin P.

    2015-10-01

    We extend the applicability range of fermionic path integral Monte Carlo simulations to heavier elements and lower temperatures by introducing various localized nodal surfaces. Hartree-Fock nodes yield the most accurate prediction for pressure and internal energy, which we combine with the results from density functional molecular dynamics simulations to obtain a consistent equation of state for hot, dense silicon under plasma conditions and in the regime of warm dense matter (2.3 - 18.6 g cm-3 , 5.0 ×1 05-1.3 ×1 08 K ). The shock Hugoniot curve is derived and the structure of the fluid is characterized with various pair correlation functions.

  12. Hybrid integrated optic modules for real-time signal processing

    NASA Technical Reports Server (NTRS)

    Tsai, C. S.

    1984-01-01

    The most recent progress on four relatively new hybrid integrated optic device modules in LiNbO3 waveguides and one in YIG/GGG waveguide that are currently being studied are discussed. The five hybrid modules include a time-integrating acoustooptic correlator, a channel waveguide acoustooptic frequency shifter/modulator, an electrooptic channel waveguide total internal reflection moculator/switch, an electrooptic analog-to-digital converter using a Fabry-Perot modulator array, and a noncollinear magnetooptic modulator using magnetostatic surface waves. All of these devices possess the desirable characteristics of very large bandwidth (GHz or higher), very small substrate size along the optical path (typically 1.5 cm or less), single-mode optical propagation, and low drive power requirement. The devices utilize either acoustooptic, electrooptic or magnetooptic effects in planar or channel waveguides and, therefore, act as efficient interface devices between a light wave and temporal signals. Major areas of application lie in wideband multichannel optical real-time signal processing and communications. Some of the specific applications include spectral analysis and correlation of radio frequency (RF) signals, fiber-optic sensing, optical computing and multiport switching/routing, and analog-to-digital conversion of wide RF signals.

  13. Modeling the first stages of Cu precipitation in α-Fe using a hybrid atomistic kinetic Monte Carlo approach

    NASA Astrophysics Data System (ADS)

    Castin, N.; Pascuet, M. I.; Malerba, L.

    2011-08-01

    We simulate the coherent stage of Cu precipitation in α-Fe with an atomistic kinetic Monte Carlo (AKMC) model. The vacancy migration energy as a function of the local chemical environment is provided on-the-fly by a neural network, trained with high precision on values calculated with the nudged elastic band method, using a suitable interatomic potential. To speed up the simulation, however, we modify the standard AKMC algorithm by treating large Cu clusters as objects, similarly to object kinetic Monte Carlo approaches. Seamless matching between the fully atomistic and the coarse-grained approach is achieved again by using a neural network, that provides all stability and mobility parameters for large Cu clusters, after training on atomistically informed results. The resulting hybrid algorithm allows long thermal annealing experiments to be simulated, within a reasonable CPU time. The results obtained are in very good agreement with several series of experimental data available from the literature, spanning over different conditions of temperature and alloy composition. We deduce from these results and relevant parametric studies that the mobility of Cu clusters containing one vacancy plays a central role in the precipitation mechanism.

  14. Modeling the first stages of Cu precipitation in α-Fe using a hybrid atomistic kinetic Monte Carlo approach.

    PubMed

    Castin, N; Pascuet, M I; Malerba, L

    2011-08-14

    We simulate the coherent stage of Cu precipitation in α-Fe with an atomistic kinetic Monte Carlo (AKMC) model. The vacancy migration energy as a function of the local chemical environment is provided on-the-fly by a neural network, trained with high precision on values calculated with the nudged elastic band method, using a suitable interatomic potential. To speed up the simulation, however, we modify the standard AKMC algorithm by treating large Cu clusters as objects, similarly to object kinetic Monte Carlo approaches. Seamless matching between the fully atomistic and the coarse-grained approach is achieved again by using a neural network, that provides all stability and mobility parameters for large Cu clusters, after training on atomistically informed results. The resulting hybrid algorithm allows long thermal annealing experiments to be simulated, within a reasonable CPU time. The results obtained are in very good agreement with several series of experimental data available from the literature, spanning over different conditions of temperature and alloy composition. We deduce from these results and relevant parametric studies that the mobility of Cu clusters containing one vacancy plays a central role in the precipitation mechanism. PMID:21842938

  15. A hybrid Markov chain Monte Carlo method for generating permeability fields conditioned to multiwell pressure data and prior information

    SciTech Connect

    Bonet-Cunha, L.; Oliver, D.S.; Redner, R.A.

    1996-12-31

    In order to properly evaluate the uncertainty in reservoir performance predictions, it is necessary to construct and sample the a posteriori probability density functions for the rock property fields. In this work, the a posteriori probability density function is constructed based on prior means and variograms (covariance function) for log-permeability and multiwell pressure data. Within the context of sampling the probability density function, we argue that the notion of equally probable realizations is the wrong paradigm for reservoir characterization. If the simulation of Gaussian random fields with a known variogram is the objective, it is shown that the variogram should not be incorporated directly into the objective function if simulated annealing is applied either to sample the a posteriori probability density function or to estimate a global minimum of the associated objective function. It is shown that the hybrid Markov chain Monte Carlo method provides a way to explore more fully the set of plausible log-permeability fields and does not suffer from the high rejection rates of more standard Markov chain Monte Carlo methods.

  16. Silicon-integrated short-wavelength hybrid-cavity VCSEL.

    PubMed

    Haglund, Emanuel P; Kumari, Sulakshna; Westbergh, Petter; Gustavsson, Johan S; Roelkens, Gunther; Baets, Roel; Larsson, Anders

    2015-12-28

    We demonstrate a short-wavelength hybrid-cavity vertical-cavity surface-emitting laser (VCSEL) heterogeneously integrated on silicon. A GaAs-based "half-VCSEL" has been attached to a dielectric distributed Bragg reflector (DBR) on a silicon wafer using ultra-thin divinylsiloxane-bis-benzocyclobutene (DVS-BCB) adhesive bonding, thereby creating a cavity with the standing-wave optical field extending over the silicon- and GaAs-based parts of the cavity. A 9 µm oxide aperture diameter VCSEL with a threshold current of 1.2 mA produces 1.6 mW optical output power at 6.0 mA bias current with a wavelength of ~845 nm. PMID:26832027

  17. An integrated Monte Carlo dosimetric verification system for radiotherapy treatment planning

    NASA Astrophysics Data System (ADS)

    Yamamoto, T.; Mizowaki, T.; Miyabe, Y.; Takegawa, H.; Narita, Y.; Yano, S.; Nagata, Y.; Teshima, T.; Hiraoka, M.

    2007-04-01

    An integrated Monte Carlo (MC) dose calculation system, MCRTV (Monte Carlo for radiotherapy treatment plan verification), has been developed for clinical treatment plan verification, especially for routine quality assurance (QA) of intensity-modulated radiotherapy (IMRT) plans. The MCRTV system consists of the EGS4/PRESTA MC codes originally written for particle transport through the accelerator, the multileaf collimator (MLC), and the patient/phantom, which run on a 28-CPU Linux cluster, and the associated software developed for the clinical implementation. MCRTV has an interface with a commercial treatment planning system (TPS) (Eclipse, Varian Medical Systems, Palo Alto, CA, USA) and reads the information needed for MC computation transferred in DICOM-RT format. The key features of MCRTV have been presented in detail in this paper. The phase-space data of our 15 MV photon beam from a Varian Clinac 2300C/D have been developed and several benchmarks have been performed under homogeneous and several inhomogeneous conditions (including water, aluminium, lung and bone media). The MC results agreed with the ionization chamber measurements to within 1% and 2% for homogeneous and inhomogeneous conditions, respectively. The MC calculation for a clinical prostate IMRT treatment plan validated the implementation of the beams and the patient/phantom configuration in MCRTV.

  18. Hybrid automated reliability predictor integrated work station (HiREL)

    NASA Technical Reports Server (NTRS)

    Bavuso, Salvatore J.

    1991-01-01

    The Hybrid Automated Reliability Predictor (HARP) integrated reliability (HiREL) workstation tool system marks another step toward the goal of producing a totally integrated computer aided design (CAD) workstation design capability. Since a reliability engineer must generally graphically represent a reliability model before he can solve it, the use of a graphical input description language increases productivity and decreases the incidence of error. The captured image displayed on a cathode ray tube (CRT) screen serves as a documented copy of the model and provides the data for automatic input to the HARP reliability model solver. The introduction of dependency gates to a fault tree notation allows the modeling of very large fault tolerant system models using a concise and visually recognizable and familiar graphical language. In addition to aiding in the validation of the reliability model, the concise graphical representation presents company management, regulatory agencies, and company customers a means of expressing a complex model that is readily understandable. The graphical postprocessor computer program HARPO (HARP Output) makes it possible for reliability engineers to quickly analyze huge amounts of reliability/availability data to observe trends due to exploratory design changes.

  19. Integration of conflict into integrative taxonomy: fitting hybridization in species delimitation of Mesocarabus (Coleoptera: Carabidae).

    PubMed

    Andjar, C; Arribas, P; Ruiz, C; Serrano, J; Gmez-Zurita, J

    2014-09-01

    In species differentiation, characters may not diverge synchronously, and there are also processes that shuffle character states in lineages descendant from a common ancestor. Species are thus expected to show some degree of incongruence among characters; therefore, taxonomic delimitation can benefit from integrative approaches and objective strategies that account for character conflict. We illustrate the potential of exploiting conflict for species delimitation in a study case of ground beetles of the subgenus Carabus (Mesocarabus), where traditional taxonomy does not accurately delimit species. The molecular phylogenies of four mitochondrial and three nuclear genes, cladistic analysis of the aedeagus, ecological niche divergence and morphometry of pronotal shape in more than 500 specimens of Mesocarabus show that these characters are not fully congruent. For these data, a three-step operational strategy is proposed for species delimitation by (i) delineating candidate species based on the integration of incongruence among conclusive lines of evidence, (ii) corroborating candidate species with inconclusive lines of evidence and (iii) refining a final species proposal based on an integrated characterization of candidate species based on the evolutionary analysis of incongruence. This procedure provided a general understanding of the reticulate process of hybridization and introgression acting on Mesocarabus and generated the hypothesis of seven Mesocarabus species, including two putative hybrid lineages. Our work emphasizes the importance of incorporating critical analyses of character and phylogenetic conflict to infer both the evolutionary history and species boundaries through an integrative taxonomic approach. PMID:24828576

  20. Radiation Transport for Explosive Outflows: A Multigroup Hybrid Monte Carlo Method

    NASA Astrophysics Data System (ADS)

    Wollaeger, Ryan T.; van Rossum, Daniel R.; Graziani, Carlo; Couch, Sean M.; Jordan, George C., IV; Lamb, Donald Q.; Moses, Gregory A.

    2013-12-01

    We explore Implicit Monte Carlo (IMC) and discrete diffusion Monte Carlo (DDMC) for radiation transport in high-velocity outflows with structured opacity. The IMC method is a stochastic computational technique for nonlinear radiation transport. IMC is partially implicit in time and may suffer in efficiency when tracking MC particles through optically thick materials. DDMC accelerates IMC in diffusive domains. Abdikamalov extended IMC and DDMC to multigroup, velocity-dependent transport with the intent of modeling neutrino dynamics in core-collapse supernovae. Densmore has also formulated a multifrequency extension to the originally gray DDMC method. We rigorously formulate IMC and DDMC over a high-velocity Lagrangian grid for possible application to photon transport in the post-explosion phase of Type Ia supernovae. This formulation includes an analysis that yields an additional factor in the standard IMC-to-DDMC spatial interface condition. To our knowledge the new boundary condition is distinct from others presented in prior DDMC literature. The method is suitable for a variety of opacity distributions and may be applied to semi-relativistic radiation transport in simple fluids and geometries. Additionally, we test the code, called SuperNu, using an analytic solution having static material, as well as with a manufactured solution for moving material with structured opacities. Finally, we demonstrate with a simple source and 10 group logarithmic wavelength grid that IMC-DDMC performs better than pure IMC in terms of accuracy and speed when there are large disparities between the magnitudes of opacities in adjacent groups. We also present and test our implementation of the new boundary condition.

  1. Torsional path integral Monte Carlo method for the quantum simulation of large molecules

    NASA Astrophysics Data System (ADS)

    Miller, Thomas F.; Clary, David C.

    2002-05-01

    A molecular application is introduced for calculating quantum statistical mechanical expectation values of large molecules at nonzero temperatures. The Torsional Path Integral Monte Carlo (TPIMC) technique applies an uncoupled winding number formalism to the torsional degrees of freedom in molecular systems. The internal energy of the molecules ethane, n-butane, n-octane, and enkephalin are calculated at standard temperature using the TPIMC technique and compared to the expectation values obtained using the harmonic oscillator approximation and a variational technique. All studied molecules exhibited significant quantum mechanical contributions to their internal energy expectation values according to the TPIMC technique. The harmonic oscillator approximation approach to calculating the internal energy performs well for the molecules presented in this study but is limited by its neglect of both anharmonicity effects and the potential coupling of intramolecular torsions.

  2. Accelerating execution of the integrated TIGER series Monte Carlo radiation transport codes

    SciTech Connect

    Smith, L.M.; Hochstedler, R.D.

    1997-02-01

    Execution of the integrated TIGER series (ITS) of coupled electron/photon Monte Carlo radiation transport codes has been accelerated by modifying the FORTRAN source code for more efficient computation. Each member code of ITS was benchmarked and profiled with a specific test case that directed the acceleration effort toward the most computationally intensive subroutines. Techniques for accelerating these subroutines included replacing linear search algorithms with binary versions, replacing the pseudo-random number generator, reducing program memory allocation, and proofing the input files for geometrical redundancies. All techniques produced identical or statistically similar results to the original code. Final benchmark timing of the accelerated code resulted in speed-up factors of 2.00 for TIGER (the one-dimensional slab geometry code), 1.74 for CYLTRAN (the two-dimensional cylindrical geometry code), and 1.90 for ACCEPT (the arbitrary three-dimensional geometry code).

  3. A reverse Monte Carlo and RISM integral equation study of liquid nitrogen

    NASA Astrophysics Data System (ADS)

    Radnai, Tams; Bak, Imre; Jedlovszky, Pl; Plinks, Gbor

    The orientational correlations between molecules of liquid nitrogen are studied on the basis of a series expansion of the pair correlation function as a sum of spherical harmonics. The molecular pair correlation function is calculated using the reference interaction site model theory, and the reverse Monte Carlo (RMC) method is applied to derive a set of molecular configurations consistent with the results of the integral equation theory. The results of this new application of the RMC method are discussed in detail. The orientational correlation functions are in good agreement with the results of M. A. Howe (1990, Molec. Phys., 69, 161), who used experimental functions for the RMC fitting procedure. Examination of the uniqueness of the RMC method revealed that the physical reliability of the configurations produced by RMC modelling cannot be decided solely on the basis of the results of the fitting procedure.

  4. Excitonic effects in two-dimensional semiconductors: Path integral Monte Carlo approach

    SciTech Connect

    Velizhanin, Kirill A.; Saxena, Avadh

    2015-11-11

    The most striking features of novel two-dimensional semiconductors (e.g., transition metal dichalcogenide monolayers or phosphorene) is a strong Coulomb interaction between charge carriers resulting in large excitonic effects. In particular, this leads to the formation of multicarrier bound states upon photoexcitation (e.g., excitons, trions, and biexcitons), which could remain stable at near-room temperatures and contribute significantly to the optical properties of such materials. In our work we have used the path integral Monte Carlo methodology to numerically study properties of multicarrier bound states in two-dimensional semiconductors. Specifically, we have accurately investigated and tabulated the dependence of single-exciton, trion, and biexciton binding energies on the strength of dielectric screening, including the limiting cases of very strong and very weak screening. Our results of this work are potentially useful in the analysis of experimental data and benchmarking of theoretical and computational models.

  5. Excitonic effects in two-dimensional semiconductors: Path integral Monte Carlo approach

    DOE PAGESBeta

    Velizhanin, Kirill A.; Saxena, Avadh

    2015-11-11

    The most striking features of novel two-dimensional semiconductors (e.g., transition metal dichalcogenide monolayers or phosphorene) is a strong Coulomb interaction between charge carriers resulting in large excitonic effects. In particular, this leads to the formation of multicarrier bound states upon photoexcitation (e.g., excitons, trions, and biexcitons), which could remain stable at near-room temperatures and contribute significantly to the optical properties of such materials. In our work we have used the path integral Monte Carlo methodology to numerically study properties of multicarrier bound states in two-dimensional semiconductors. Specifically, we have accurately investigated and tabulated the dependence of single-exciton, trion, and biexcitonmore » binding energies on the strength of dielectric screening, including the limiting cases of very strong and very weak screening. Our results of this work are potentially useful in the analysis of experimental data and benchmarking of theoretical and computational models.« less

  6. Fermionic path-integral Monte Carlo results for the uniform electron gas at finite temperature

    NASA Astrophysics Data System (ADS)

    Filinov, V. S.; Fortov, V. E.; Bonitz, M.; Moldabekov, Zh.

    2015-03-01

    The uniform electron gas (UEG) at finite temperature has recently attracted substantial interest due to the experimental progress in the field of warm dense matter. To explain the experimental data, accurate theoretical models for high-density plasmas are needed that depend crucially on the quality of the thermodynamic properties of the quantum degenerate nonideal electrons and of the treatment of their interaction with the positive background. Recent fixed-node path-integral Monte Carlo (RPIMC) data are believed to be the most accurate for the UEG at finite temperature, but they become questionable at high degeneracy when the Brueckner parameter rs=a /aB —the ratio of the mean interparticle distance to the Bohr radius—approaches 1. The validity range of these simulations and their predictive capabilities for the UEG are presently unknown. This is due to the unknown quality of the used fixed nodes and of the finite-size scaling from N =33 simulated particles (per spin projection) to the macroscopic limit. To analyze these questions, we present alternative direct fermionic path integral Monte Carlo (DPIMC) simulations that are independent from RPIMC. Our simulations take into account quantum effects not only in the electron system but also in their interaction with the uniform positive background. Also, we use substantially larger particle numbers (up to three times more) and perform an extrapolation to the macroscopic limit. We observe very good agreement with RPIMC, for the polarized electron gas, up to moderate densities around rs=4 , and larger deviations for the unpolarized case, for low temperatures. For higher densities (high electron degeneracy), rs≲1.5 , both RPIMC and DPIMC are problematic due to the increased fermion sign problem.

  7. An Event-Driven Hybrid Molecular Dynamics and Direct Simulation Monte Carlo Algorithm

    SciTech Connect

    Donev, A; Garcia, A L; Alder, B J

    2007-07-30

    A novel algorithm is developed for the simulation of polymer chains suspended in a solvent. The polymers are represented as chains of hard spheres tethered by square wells and interact with the solvent particles with hard core potentials. The algorithm uses event-driven molecular dynamics (MD) for the simulation of the polymer chain and the interactions between the chain beads and the surrounding solvent particles. The interactions between the solvent particles themselves are not treated deterministically as in event-driven algorithms, rather, the momentum and energy exchange in the solvent is determined stochastically using the Direct Simulation Monte Carlo (DSMC) method. The coupling between the solvent and the solute is consistently represented at the particle level, however, unlike full MD simulations of both the solvent and the solute, the spatial structure of the solvent is ignored. The algorithm is described in detail and applied to the study of the dynamics of a polymer chain tethered to a hard wall subjected to uniform shear. The algorithm closely reproduces full MD simulations with two orders of magnitude greater efficiency. Results do not confirm the existence of periodic (cycling) motion of the polymer chain.

  8. A Monte Carlo Application to Approximate the Integral from a to b of e Raised to the x Squared.

    ERIC Educational Resources Information Center

    Easterday, Kenneth; Smith, Tommy

    1992-01-01

    Proposes an alternative means of approximating the value of complex integrals, the Monte Carlo procedure. Incorporating a discrete approach and probability, an approximation is obtained from the ratio of computer-generated points falling under the curve to the number of points generated in a predetermined rectangle. (MDH)

  9. Extension of the Integrated Tiger Series (ITS) of electron-photon Monte Carlo codes to 100 GeV

    SciTech Connect

    Miller, S.G.

    1988-08-01

    Version 2.1 of the Integrated Tiger Series (ITS) of electron-photon Monte Carlo codes was modified to extend their ability to model interactions up to 100 GeV. Benchmarks against experimental results conducted at 10 and 15 GeV confirm the accuracy of the extended codes. 12 refs., 2 figs., 2 tabs.

  10. Design of a hybrid-integrated MEMS scanning grating spectrometer

    NASA Astrophysics Data System (ADS)

    Pügner, Tino; Knobbe, Jens; Grüger, Heinrich; Schenk, Harald

    2011-10-01

    Optical MEMS (micro electro mechanical systems) have been used to reduce size, weight and costs of any kind of optical systems very successfully starting in the last decades. Scientists at Fraunhofer IPMS invented a resonant drive for 1-d and 2-d MEMS scanning mirror devices. Besides mirrors also scanning gratings have been realized. Now, rapidly growing new applications demand for enhanced functions and further miniaturization. This task cannot be solved by simply putting more functionality into the MEMS chip, for example grating and slit structures, but by three dimensional hybrid integration of the complete optical system into a stack of several functional substrates. Here we present the optical system design and realization strategy for a scanning grating spectrometer for the near infrared (NIR) range. First samples will be mounted from single components by a bonder tool (Finetech Fineplacer Femto) but the option of wafer assembly will be kept open for future developments. Extremely miniaturized NIR spectrometer could serve a wide variety of applications for handheld devices from food quality analysis to medical services or materials identification.

  11. The Monte Carlo Integration Computer as an Instructional Model for the Simulation of Equilibrium and Kinetic Chemical Processes: The Development and Evaluation of a Teaching Aid.

    ERIC Educational Resources Information Center

    Wood, Dean Arthur

    A special purpose digital computer which utilizes the Monte Carlo integration method of obtaining simulations of chemical processes was developed and constructed. The computer, designated as the Monte Carlo Integration Computer (MCIC), was designed as an instructional model for the illustration of kinetic and equilibrium processes, and was…

  12. Kinetic isotope effect in malonaldehyde determined from path integral Monte Carlo simulations.

    PubMed

    Huang, Jing; Buchowiecki, Marcin; Nagy, Tibor; Vaníček, Jiří; Meuwly, Markus

    2014-01-01

    The primary H/D kinetic isotope effect on the intramolecular proton transfer in malonaldehyde is determined from quantum instanton path integral Monte Carlo simulations on a fully dimensional and validated potential energy surface for temperatures between 250 and 1500 K. Our calculations, based on thermodynamic integration with respect to the mass of the transferring particle, are significantly accelerated by the direct evaluation of the kinetic isotope effect instead of computing it as a ratio of two rate constants. At room temperature, the KIE from the present simulations is 5.2 ± 0.4. The KIE is found to vary considerably as a function of temperature and the low-T behaviour is dominated by the fact that the free energy derivative in the reactant state increases more rapidly than in the transition state. Detailed analysis of the various contributions to the quantum rate constant together with estimates for rates from conventional transition state theory and from periodic orbit theory suggest that the KIE in malonaldehyde is dominated by zero point energy effects and that tunneling plays a minor role at room temperature. PMID:24233185

  13. Fractional volume integration in two-dimensional NMR spectra: CAKE, a Monte Carlo approach.

    PubMed

    Romano, Rocco; Paris, Debora; Acernese, Fausto; Barone, Fabrizio; Motta, Andrea

    2008-06-01

    Quantitative information from multi-dimensional NMR experiments can be obtained by peak volume integration. The standard procedure (selection of a region around the chosen peak and addition of all values) is often biased by poor peak definition because of peak overlap. Here we describe a simple method, called CAKE, for volume integration of (partially) overlapping peaks. Assuming the axial symmetry of two-dimensional NMR peaks, as it occurs in NOESY and TOCSY when Lorentz-Gauss transformation of the signals is carried out, CAKE estimates the peak volume by multiplying a volume fraction by a factor R. It represents a proportionality ratio between the total and the fractional volume, which is identified as a slice in an exposed region of the overlapping peaks. The volume fraction is obtained via Monte Carlo Hit-or-Miss technique, which proved to be the most efficient because of the small region and the limited number of points within the selected area. Tests on simulated and experimental peaks, with different degrees of overlap and signal-to-noise ratios, show that CAKE results in improved volume estimates. A main advantage of CAKE is that the volume fraction can be flexibly chosen so as to minimize the effect of overlap, frequently observed in two-dimensional spectra. PMID:18396078

  14. Monte Carlo simulation of small electron fields collimated by the integrated photon MLC

    NASA Astrophysics Data System (ADS)

    Mihaljevic, Josip; Soukup, Martin; Dohm, Oliver; Alber, Markus

    2011-02-01

    In this study, a Monte Carlo (MC)-based beam model for an ELEKTA linear accelerator was established. The beam model is based on the EGSnrc Monte Carlo code, whereby electron beams with nominal energies of 10, 12 and 15 MeV were considered. For collimation of the electron beam, only the integrated photon multi-leaf-collimators (MLCs) were used. No additional secondary or tertiary add-ons like applicators, cutouts or dedicated electron MLCs were included. The source parameters of the initial electron beam were derived semi-automatically from measurements of depth-dose curves and lateral profiles in a water phantom. A routine to determine the initial electron energy spectra was developed which fits a Gaussian spectrum to the most prominent features of depth-dose curves. The comparisons of calculated and measured depth-dose curves demonstrated agreement within 1%/1 mm. The source divergence angle of initial electrons was fitted to lateral dose profiles beyond the range of electrons, where the imparted dose is mainly due to bremsstrahlung produced in the scattering foils. For accurate modelling of narrow beam segments, the influence of air density on dose calculation was studied. The air density for simulations was adjusted to local values (433 m above sea level) and compared with the standard air supplied by the ICRU data set. The results indicate that the air density is an influential parameter for dose calculations. Furthermore, the default value of the BEAMnrc parameter 'skin depth' for the boundary crossing algorithm was found to be inadequate for the modelling of small electron fields. A higher value for this parameter eliminated discrepancies in too broad dose profiles and an increased dose along the central axis. The beam model was validated with measurements, whereby an agreement mostly within 3%/3 mm was found.

  15. Monte Carlo simulation of small electron fields collimated by the integrated photon MLC.

    PubMed

    Mihaljevic, Josip; Soukup, Martin; Dohm, Oliver; Alber, Markus

    2011-02-01

    In this study, a Monte Carlo (MC)-based beam model for an ELEKTA linear accelerator was established. The beam model is based on the EGSnrc Monte Carlo code, whereby electron beams with nominal energies of 10, 12 and 15 MeV were considered. For collimation of the electron beam, only the integrated photon multi-leaf-collimators (MLCs) were used. No additional secondary or tertiary add-ons like applicators, cutouts or dedicated electron MLCs were included. The source parameters of the initial electron beam were derived semi-automatically from measurements of depth-dose curves and lateral profiles in a water phantom. A routine to determine the initial electron energy spectra was developed which fits a Gaussian spectrum to the most prominent features of depth-dose curves. The comparisons of calculated and measured depth-dose curves demonstrated agreement within 1%/1 mm. The source divergence angle of initial electrons was fitted to lateral dose profiles beyond the range of electrons, where the imparted dose is mainly due to bremsstrahlung produced in the scattering foils. For accurate modelling of narrow beam segments, the influence of air density on dose calculation was studied. The air density for simulations was adjusted to local values (433 m above sea level) and compared with the standard air supplied by the ICRU data set. The results indicate that the air density is an influential parameter for dose calculations. Furthermore, the default value of the BEAMnrc parameter 'skin depth' for the boundary crossing algorithm was found to be inadequate for the modelling of small electron fields. A higher value for this parameter eliminated discrepancies in too broad dose profiles and an increased dose along the central axis. The beam model was validated with measurements, whereby an agreement mostly within 3%/3 mm was found. PMID:21242628

  16. Hybrid Monte Carlo method for off-lattice simulation of processes involving steps with widely varying rates

    SciTech Connect

    Clark, M.M.; Raff, L.M.; Scott, H.L.

    1996-11-01

    A hybrid Monte Carlo simulation method consisting of kinetic and equilibrium moves is presented. The method is applicable to any system involving {ital N} different processes whose rates may vary by orders of magnitude. We show that the method easily permits the propagation of the system through macroscopic time scales by application to a study of chemical vapor deposition diamond-film growth. The application is an off-lattice simulation utilizing CH{sub 3} as the growth species on a diamond [111] surface, and incorporating a computationally expensive, many-body potential surface. We show that, by using our method, it is possible to simulate a continuous system of several thousand atoms, with no underlying grid and with a realistic potential for times on the order of milliseconds. The growth rate of the simulated surface is consistent with experimental growth rates, and the simulation sheds light on possible morphologies during the early stages of diamond film formation. {copyright} {ital 1996 American Institute of Physics.}

  17. Effect of small amounts of hydrogen added to argon glow discharges: hybrid Monte Carlo-fluid model.

    PubMed

    Bogaerts, Annemie; Gijbels, Renaat

    2002-05-01

    A hybrid Monte Carlo-fluid modeling network is developed for an argon-hydrogen mixture, to predict the effect of small amounts of hydrogen added to a dc argon glow discharge. The species considered in the model include the Ar gas atoms, electrons, Ar(+) ions and fast Ar atoms, ArH(+), H(+), H(2)(+) and H(3)(+) ions, and H atoms and H(2) molecules, as well as Ar metastable atoms, sputtered Cu atoms, and the corresponding Cu(+) ions. Sixty-five reactions between these species are incorporated in the model. The effect of hydrogen on various calculation results is investigated, such as the species densities, the relative role of different production and loss processes for the various species, the cathode sputtering rate and contributions by different bombarding species, and the dissociation degree of H(2) and the ionization degree of Ar and Cu. The calculation results are presented and discussed for 1% H(2) addition, and comparison is also made with a pure argon discharge and with only 0.1% H(2) addition. PMID:12059710

  18. Improved measurement scheme of the self energy in the worm-sampled hybridization-expansion quantum Monte Carlo

    NASA Astrophysics Data System (ADS)

    Han, Mancheon; Lee, Choong-Ki; Choi, Hyoung Joon

    Hybridization-expansion continuous-time quantum Monte Carlo (CT-HYB) is a popular approach in real material researches because it allows to deal with non-density-density-type interaction. In the conventional CT-HYB, we measure Green's function and find the self energy from the Dyson equation. Because one needs to compute the inverse of the statistical data in this approach, obtained self energy is very sensitive to statistical noise. For that reason, the measurement is not reliable except for low frequencies. Such an error can be suppressed by measuring a special type of higher-order correlation function and is implemented for density-density-type interaction. With the help of the recently reported worm-sampling measurement, we developed an improved self energy measurement scheme which can be applied to any type of interactions. As an illustration, we calculated the self energy for the 3-orbital Hubbard-Kanamori-type Hamiltonian with our newly developed method. This work was supported by NRF of Korea (Grant No. 2011-0018306) and KISTI supercomputing center (Project No. KSC-2015-C3-039)

  19. Equation of state of an interacting Bose gas at finite temperature: A path-integral Monte Carlo study

    SciTech Connect

    Pilati, S.; Giorgini, S.; Sakkos, K.; Boronat, J.; Casulleras, J.

    2006-10-15

    By using exact path-integral Monte Carlo methods we calculate the equation of state of an interacting Bose gas as a function of temperature both below and above the superfluid transition. The universal character of the equation of state for dilute systems and low temperatures is investigated by modeling the interatomic interactions using different repulsive potentials corresponding to the same s-wave scattering length. The results obtained for the energy and the pressure are compared to the virial expansion for temperatures larger than the critical temperature. At very low temperatures we find agreement with the ground-state energy calculated using the diffusion Monte Carlo method.

  20. Dynamical estimation of neuron and network properties II: Path integral Monte Carlo methods.

    PubMed

    Kostuk, Mark; Toth, Bryan A; Meliza, C Daniel; Margoliash, Daniel; Abarbanel, Henry D I

    2012-03-01

    Hodgkin-Huxley (HH) models of neuronal membrane dynamics consist of a set of nonlinear differential equations that describe the time-varying conductance of various ion channels. Using observations of voltage alone we show how to estimate the unknown parameters and unobserved state variables of an HH model in the expected circumstance that the measurements are noisy, the model has errors, and the state of the neuron is not known when observations commence. The joint probability distribution of the observed membrane voltage and the unobserved state variables and parameters of these models is a path integral through the model state space. The solution to this integral allows estimation of the parameters and thus a characterization of many biological properties of interest, including channel complement and density, that give rise to a neuron's electrophysiological behavior. This paper describes a method for directly evaluating the path integral using a Monte Carlo numerical approach. This provides estimates not only of the expected values of model parameters but also of their posterior uncertainty. Using test data simulated from neuronal models comprising several common channels, we show that short (<50 ms) intracellular recordings from neurons stimulated with a complex time-varying current yield accurate and precise estimates of the model parameters as well as accurate predictions of the future behavior of the neuron. We also show that this method is robust to errors in model specification, supporting model development for biological preparations in which the channel expression and other biophysical properties of the neurons are not fully known. PMID:22526358

  1. Monte Carlo solution of the volume-integral equation of electromagnetic scattering

    NASA Astrophysics Data System (ADS)

    Peltoniemi, J.; Muinonen, K.

    2014-07-01

    Electromagnetic scattering is often the main physical process to be understood when interpreting the observations of asteroids, comets, and meteors. Modeling the scattering faces still many problems, and one needs to assess several different cases: multiple scattering and shadowing by the rough surface, multiple scattering inside a surface element, and single scattering by a small object. Our specific goal is to extend the electromagnetic techniques to larger and more complicated objects, and derive approximations taking into account the most important effects of waves. Here we experiment with Monte Carlo techniques: can they provide something new to solving the scattering problems? The electromagnetic wave equation in the presence of a scatterer of volume V and refractive index m, with an incident wave EE_0, including boundary conditions and the scattering condition at infinity, can be presented in the form of an integral equation EE(rr)(1+suski(rr) Q(ρ))-int_{V-V_ρ}ddrr' GG(rr-rr')suski(rr')EE(rr') =EE_0, where suski(rr)=m(rr)^2-1, Q(ρ)=-1/3+{cal O}(ρ^2)+{O'}(m^2ρ^2), {O}, and {O'} are some second- and higher-order corrections for the finite-size volume V_ρ of radius ρ around the singularity and GG is the dyadic Green's function of the form GG(RR)={exp(im kR)}/{4π R}[unittensor(1+{im}/{R}-{1}/{R^2})-RRRR(1+{3im}/{R}-{3}/{R^2})]. In general, this is solved by extending the internal field in terms of some simple basis functions, e.g., plane or spherical waves or a cubic grid, approximating the integrals in a clever way, and determining the goodness of the solution somehow, e.g., moments or least square. Whatever the choice, the solution usually converges nicely towards a correct enough solution when the scatterer is small and simple, and diverges when the scatterer becomes too complicated. With certain methods, one can reach larger scatterers faster, but the memory and CPU needs can be huge. Until today, all successful solutions are based on more or less regular quadratures. Because of the oscillating singularity of the Green's function, the quadrature must match exactly the canceling patterns of the integrand, and any improper quadrature leads to large errors. Monte Carlo based integration appears thus a very bad choice, but we take the challenge, and formulate the integration applying a three-finger rule to catch the singularity. Our other selections are the least-squares technique and plane-wave basis, though both can be freely and easily changed. The singularity is treated fully numerically, and the radius ρ is assumed so small that the correction terms do not contribute. Any other choice only worsens the accuracy, without a significant gain in speed. As with any other technique, we can solve small spheres of size x<5/|m| within an hour of processor time with about 1% accuracy for a large range of refractive indices. In speed, this technique does not compete with faster techniques such as ADDA, but in some random cases the accuracy can be even better (probably due to sub-optimal singularity formula in ADDA -- applying numerical integration also there could probably make ADDA winner in all the cases). We continue towards more complicated cases and multiple scattering to see, if some further improvements can be made.

  2. Hybrid diagnostic system: beacon-based exception analysis for multimissions - Livingstone integration

    NASA Technical Reports Server (NTRS)

    Park, Han G.; Cannon, Howard; Bajwa, Anupa; Mackey, Ryan; James, Mark; Maul, William

    2004-01-01

    This paper describes the initial integration of a hybrid reasoning system utilizing a continuous domain feature-based detector, Beacon-based Exceptions Analysis for Multimissions (BEAM), and a discrete domain model-based reasoner, Livingstone.

  3. Integrated graphene/nanoparticle hybrids for biological and electronic applications

    NASA Astrophysics Data System (ADS)

    Nguyen, Kim Truc; Zhao, Yanli

    2014-05-01

    The development of novel graphene/nanoparticle hybrid materials is currently the subject of tremendous research interest. The intrinsic exceptional assets of both graphene (including graphene oxide and reduced graphene oxide) and nanoparticles render their hybrid materials synergic properties that can be useful in various applications. In this feature review, we highlight recent developments in graphene/nanoparticle hybrids and their promising potential in electronic and biological applications. First, the latest advances in synthetic methods for the preparation of the graphene/nanoparticle hybrids are introduced, with the emphasis on approaches to (1) decorate nanoparticles onto two-dimensional graphene and (2) wrap nanoparticles with graphene sheets. The pros and cons of large-scale synthesis are also discussed. Then, the state-of-the-art of graphene/nanoparticle hybrids in electronic and biological applications is reviewed. For electronic applications, we focus on the advantages of using these hybrids in transparent conducting films, as well as energy harvesting and storage. Biological applications, electrochemical biosensing, bioimaging, and drug delivery using the hybrids are showcased. Finally, the future research prospects and challenges in this rapidly developing area are discussed.

  4. Excitonic effects in 2D semiconductors: Path Integral Monte Carlo approach

    NASA Astrophysics Data System (ADS)

    Velizhanin, Kirill; Saxena, Avadh

    One of the most striking features of novel 2D semiconductors (e.g., transition metal dichalcogenide monolayers or phosphorene) is a strong Coulomb interaction between charge carriers resulting in large excitonic effects. In particular, this leads to the formation of multi-carrier bound states (e.g., excitons, trions and biexcitons), which could remain stable at near-room temperatures and contribute significantly to optical properties of such materials. In my talk, I will report on our recent progress in using the Path Integral Monte Carlo methodology to numerically study properties of multi-carrier bound states in 2D semiconductors. Incorporating the effect of the dielectric confinement (via Keldysh potential), we have investigated and tabulated the dependence of single exciton, trion and biexciton binding energies on the strength of dielectric screening, including the limiting cases of very strong and very weak screening. The implications of the obtained results and the possible limitations of the used model will be discussed. The results of this work are potentially useful in the analysis of experimental data and benchmarking of theoretical and computational models.

  5. Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution?

    PubMed Central

    Müther, Nadine; Noske, Nadja; Ehrhardt, Anja

    2009-01-01

    The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based on these findings major improvements in vector design including the development of viral hybrid vectors for somatic integration have been achieved. This review provides a state-of-the-art overview of available hybrid vectors utilizing viruses for high transduction efficiencies in concert with various integration machineries for random and targeted integration patterns. It discusses advantages but also limitations of each vector system. PMID:21994594

  6. Streamline Integration using MPI-Hybrid Parallelism on a Large Multi-Core Architecture

    SciTech Connect

    Camp, David; Garth, Christoph; Childs, Hank; Pugmire, Dave; Joy, Kenneth I.

    2010-11-01

    Streamline computation in a very large vector field data set represents a significant challenge due to the non-local and datadependentnature of streamline integration. In this paper, we conduct a study of the performance characteristics of hybrid parallel programmingand execution as applied to streamline integration on a large, multicore platform. With multi-core processors now prevalent in clustersand supercomputers, there is a need to understand the impact of these hybrid systems in order to make the best implementation choice.We use two MPI-based distribution approaches based on established parallelization paradigms, parallelize-over-seeds and parallelize-overblocks,and present a novel MPI-hybrid algorithm for each approach to compute streamlines. Our findings indicate that the work sharing betweencores in the proposed MPI-hybrid parallel implementation results in much improved performance and consumes less communication andI/O bandwidth than a traditional, non-hybrid distributed implementation.

  7. The Integration of Psychomotor Skills in a Hybrid-PBL Dental Curriculum: The Clinical Clerkships.

    ERIC Educational Resources Information Center

    Walton, Joanne N.; MacNeil, M. A. J.; Harrison, Rosamund L.; Clark, D. Christopher

    1998-01-01

    Describes the restructuring of clinical clerkships at the University of British Columbia (Canada) dental school as part of a new, hybrid, problem-based learning (PBL) curriculum, focusing on strategies for integrating development of psychomotor skills. Methods of achieving both horizontal and vertical integration of competencies through grouping…

  8. Streamline Integration Using MPI-Hybrid Parallelism on a Large Multicore Architecture

    SciTech Connect

    Garth, Christoph

    2011-01-01

    Streamline computation in a very large vector field data set represents a significant challenge due to the nonlocal and data-dependent nature of streamline integration. In this paper, we conduct a study of the performance characteristics of hybrid parallel programming and execution as applied to streamline integration on a large, multicore platform. With multicore processors now prevalent in clusters and supercomputers, there is a need to understand the impact of these hybrid systems in order to make the best implementation choice. We use two MPI-based distribution approaches based on established parallelization paradigms, parallelize over seeds and parallelize over blocks, and present a novel MPI-hybrid algorithm for each approach to compute streamlines. Our findings indicate that the work sharing between cores in the proposed MPI-hybrid parallel implementation results in much improved performance and consumes less communication and I/O bandwidth than a traditional, nonhybrid distributed implementation.

  9. Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration

    PubMed Central

    Zhang, Wenli; Muck-Hausl, Martin; Wang, Jichang; Sun, Chuanbo; Gebbing, Maren; Miskey, Csaba; Ivics, Zoltan; Izsvak, Zsuzsanna; Ehrhardt, Anja

    2013-01-01

    We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyperactive Sleeping Beauty (SB) transposase HSB5 for somatic integration and we could show stabilized transgene expression in mice and a canine model for hemophilia B. However, the safety profile of these hybrid-vectors with respect to vector dose and genotoxicity remains to be investigated. Herein, we evaluated this hybrid-vector system in C57Bl/6 mice with escalating vector dose settings. We found that in all mice which received the hyperactive SB transposase, transgene expression levels were stabilized in a dose-dependent manner and that the highest vector dose was accompanied by fatalities in mice. To analyze potential genotoxic side-effects due to somatic integration into host chromosomes, we performed a genome-wide integration site analysis using linker-mediated PCR (LM-PCR) and linear amplification-mediated PCR (LAM-PCR). Analysis of genomic DNA samples obtained from HSB5 treated female and male mice revealed a total of 1327 unique transposition events. Overall the chromosomal distribution pattern was close-to-random and we observed a random integration profile with respect to integration into gene and non-gene areas. Notably, when using the LM-PCR protocol, 27 extra-chromosomal integration events were identified, most likely caused by transposon excision and subsequent transposition into the delivered adenoviral vector genome. In total, this study provides a careful evaluation of the safety profile of adenovirus/Sleeping Beauty transposase hybrid-vectors. The obtained information will be useful when designing future preclinical studies utilizing hybrid-vectors in small and large animal models. PMID:24124483

  10. Evaluation of Monte Carlo Electron-Transport Algorithms in the Integrated Tiger Series Codes for Stochastic-Media Simulations

    NASA Astrophysics Data System (ADS)

    Franke, Brian C.; Kensek, Ronald P.; Prinja, Anil K.

    2014-06-01

    Stochastic-media simulations require numerous boundary crossings. We consider two Monte Carlo electron transport approaches and evaluate accuracy with numerous material boundaries. In the condensed-history method, approximations are made based on infinite-medium solutions for multiple scattering over some track length. Typically, further approximations are employed for material-boundary crossings where infinite-medium solutions become invalid. We have previously explored an alternative "condensed transport" formulation, a Generalized Boltzmann-Fokker-Planck GBFP method, which requires no special boundary treatment but instead uses approximations to the electron-scattering cross sections. Some limited capabilities for analog transport and a GBFP method have been implemented in the Integrated Tiger Series (ITS) codes. Improvements have been made to the condensed history algorithm. The performance of the ITS condensed-history and condensed-transport algorithms are assessed for material-boundary crossings. These assessments are made both by introducing artificial material boundaries and by comparison to analog Monte Carlo simulations.

  11. Integrated Cost and Schedule using Monte Carlo Simulation of a CPM Model - 12419

    SciTech Connect

    Hulett, David T.; Nosbisch, Michael R.

    2012-07-01

    This discussion of the recommended practice (RP) 57R-09 of AACE International defines the integrated analysis of schedule and cost risk to estimate the appropriate level of cost and schedule contingency reserve on projects. The main contribution of this RP is to include the impact of schedule risk on cost risk and hence on the need for cost contingency reserves. Additional benefits include the prioritizing of the risks to cost, some of which are risks to schedule, so that risk mitigation may be conducted in a cost-effective way, scatter diagrams of time-cost pairs for developing joint targets of time and cost, and probabilistic cash flow which shows cash flow at different levels of certainty. Integrating cost and schedule risk into one analysis based on the project schedule loaded with costed resources from the cost estimate provides both: (1) more accurate cost estimates than if the schedule risk were ignored or incorporated only partially, and (2) illustrates the importance of schedule risk to cost risk when the durations of activities using labor-type (time-dependent) resources are risky. Many activities such as detailed engineering, construction or software development are mainly conducted by people who need to be paid even if their work takes longer than scheduled. Level-of-effort resources, such as the project management team, are extreme examples of time-dependent resources, since if the project duration exceeds its planned duration the cost of these resources will increase over their budgeted amount. The integrated cost-schedule risk analysis is based on: - A high quality CPM schedule with logic tight enough so that it will provide the correct dates and critical paths during simulation automatically without manual intervention. - A contingency-free estimate of project costs that is loaded on the activities of the schedule. - Resolves inconsistencies between cost estimate and schedule that often creep into those documents as project execution proceeds. - Good-quality risk data that are usually collected in risk interviews of the project team, management and others knowledgeable in the risk of the project. The risks from the risk register are used as the basis of the risk data in the risk driver method. The risk driver method is based in the fundamental principle that identifiable risks drive overall cost and schedule risk. - A Monte Carlo simulation software program that can simulate schedule risk, burn WM2012 rate risk and time-independent resource risk. The results include the standard histograms and cumulative distributions of possible cost and time results for the project. However, by simulating both cost and time simultaneously we can collect the cost-time pairs of results and hence show the scatter diagram ('football chart') that indicates the joint probability of finishing on time and on budget. Also, we can derive the probabilistic cash flow for comparison with the time-phased project budget. Finally the risks to schedule completion and to cost can be prioritized, say at the P-80 level of confidence, to help focus the risk mitigation efforts. If the cost and schedule estimates including contingency reserves are not acceptable to the project stakeholders the project team should conduct risk mitigation workshops and studies, deciding which risk mitigation actions to take, and re-run the Monte Carlo simulation to determine the possible improvement to the project's objectives. Finally, it is recommended that the contingency reserves of cost and of time, calculated at a level that represents an acceptable degree of certainty and uncertainty for the project stakeholders, be added as a resource-loaded activity to the project schedule for strategic planning purposes. The risk analysis described in this paper is correct only for the current plan, represented by the schedule. The project contingency reserve of time and cost that are the main results of this analysis apply if that plan is to be followed. Of course project managers have the option of re-planning and re-scheduling in the face of new facts, in part by mitigating risk. This analysis identifies the high-priority risks to cost and to schedule, which assist the project manager in planning further risk mitigation. Some project managers reject the results and argue that they cannot possibly be so late or so overrun. Those project managers may be wasting an opportunity to mitigate risk and get a more favorable outcome. (authors)

  12. Method of Moments Modeling of Single Layer Microstrip Patch Antennas using GPU Acceleration and Quasi-Monte Carlo Integration

    NASA Astrophysics Data System (ADS)

    Cerjanic, Alexander M.

    The development of a spectral domain method of moments code for the modeling of single layer microstrip patch antennas is presented in this thesis. The mixed potential integral equation formulation of Maxwell's equations is used as the theoretical basis for the work, and is solved via the method of moments. General-purpose graphics processing units are used for the computation of the impedance matrix by incorporation of quasi-Monte Carlo integration. The development of the various components of the code, including Green's function, impedance matrix, and excitation vector modules are discussed with individual test cases for the major code modules. The integrated code was tested by modeling a suite of four coaxially probe fed circularly polarized single layer microstrip patch antennas and the computed results are compared to those obtained by measurement. Finally, a study examining the relationship between design parameters and S11 performance was undertaken using the code.

  13. Hybrid Integrated Label-Free Chemical and Biological Sensors

    PubMed Central

    Mehrabani, Simin; Maker, Ashley J.; Armani, Andrea M.

    2014-01-01

    Label-free sensors based on electrical, mechanical and optical transduction methods have potential applications in numerous areas of society, ranging from healthcare to environmental monitoring. Initial research in the field focused on the development and optimization of various sensor platforms fabricated from a single material system, such as fiber-based optical sensors and silicon nanowire-based electrical sensors. However, more recent research efforts have explored designing sensors fabricated from multiple materials. For example, synthetic materials and/or biomaterials can also be added to the sensor to improve its response toward analytes of interest. By leveraging the properties of the different material systems, these hybrid sensing devices can have significantly improved performance over their single-material counterparts (better sensitivity, specificity, signal to noise, and/or detection limits). This review will briefly discuss some of the methods for creating these multi-material sensor platforms and the advances enabled by this design approach. PMID:24675757

  14. Comparison of Groundstate Quantum Monte Carlo, Finite Temperature Path Integral Monte Carlo with Density Functional Theory and GW Calculations and Application to Helium at High Pressure

    NASA Astrophysics Data System (ADS)

    Militzer, B.; Khairallah, S. A.

    2008-12-01

    In this talk, four different computational methods will be compared, their advantages and disadvantages discussed, and their application to solid and fluid helium described. Helium was chosen because it is a major component of giant gas planets, was studied recently with shock wave experiments [1], and is comparatively simple to treat computationally that allowed us to apply all these different techniques. First we studied the insulator-to-metal transition in solid helium at high pressure. Density functional theory (DFT) was used to optimize the c/a ratio in the h.c.p. solid. Applying groundstate quantum Monte Carlo (QMC) [3], one finds that DFT predicts band gaps that are 4 eV too small. This inaccuracy means that DFT underestimates the metallization density by 20% and the metallization pressure by 40%. The band gaps computed with QMC are in very good agreement with GW calculations. However, GW cannot be used to correct the total energies and the equation of state (EOS). QMC yields the energy directly, and the correlation energy that is missing in DFT can be determined. To study fluids, DFT can also be combined with molecular dynamics for the nuclei by treating the electrons either in the instantaneous groundstate or by including thermal electronic excitations. At temperature above 20000K, electronic excitations affect the EOS significantly and make the material more compressible in shock wave experiments [1,2]. Despite the band gap problem in DFT, one would expect this method describe electronic excitations qualitatively. But it has not yet been demonstrated whether it is quantitatively accurate to determine correction to the EOS due to thermally excited electrons. By comparing with path integral Monte Carlo (PIMC) [4], we demonstrate DFT-MD EOS is surprising accurate but the method eventually becomes impractical because too many electronic orbital must be considered. PIMC, on the other hand, becomes more efficient at high temperature. In [4], we show that PIMC and DFT-MD can be combined to obtain one coherent EOS over several orders of magnitude in temperature. Finally, we compare our computed EOS with recent shock wave experiments [1]. We find good agreement between first-principles simulations and those experiments where the sample has been precompressed statically before the shock is launched. For the experiments without precompression, one finds that our first- principles EOS predicts a lower compressibility than was measured. This work was supported by NSF and NASA. A part of the computational resources were provided by NERSC. [1] J. Eggert et al., Phys. Rev. Lett. 100 (2008) 124503 [2] B. Militzer, Phys. Rev. Lett. 97 (2006) 175501. [3] S. Khairrallah and B. Militzer, Phys. Rev. Lett. 101 (2008) 106407. [4] B. Militzer, cond-mat/08050317.

  15. Hybrid symplectic integrators for relativistic particles in electric and magnetic fields

    NASA Astrophysics Data System (ADS)

    Channell, Paul J.

    2014-01-01

    We develop a new implicit symplectic integrator and derive the first and second order integration algorithms for it. We combine this integrator with a Yoshida composition and with a Suzuki composition to get third order hybrid symplectic integrators. We test the algorithms on an exactly solvable example from McMillan (1950 Phys. Rev. 79 498) of a particle in an electromagnetic wave and find very good results, including long term stability and exact preservation of constants associated with symmetries. We discuss the circumstances in which the new algorithms may be useful.

  16. Path-integral Monte Carlo method for the local Z2 Berry phase.

    PubMed

    Motoyama, Yuichi; Todo, Synge

    2013-02-01

    We present a loop cluster algorithm Monte Carlo method for calculating the local Z(2) Berry phase of the quantum spin models. The Berry connection, which is given as the inner product of two ground states with different local twist angles, is expressed as a Monte Carlo average on the worldlines with fixed spin configurations at the imaginary-time boundaries. The "complex weight problem" caused by the local twist is solved by adopting the meron cluster algorithm. We present the results of simulation on the antiferromagnetic Heisenberg model on an out-of-phase bond-alternating ladder to demonstrate that our method successfully detects the change in the valence bond pattern at the quantum phase transition point. We also propose that the gauge-fixed local Berry connection can be an effective tool to estimate precisely the quantum critical point. PMID:23496453

  17. Efficient ethanol recovery from fermentation broths with integrated distillation-vapor permeation hybrid process

    EPA Science Inventory

    The energy demand of distillation-molecular sieve systems for ethanol recovery/dehydration can be significant, particularly for dilute solutions. An alternative hybrid process integrating vapor stripping (like a beer still) with vapor compression and a vapor permeation membrane s...

  18. Integrated nanophotonic frequency shifter on the silicon-organic hybrid (SOH) platform for laser vibrometry

    SciTech Connect

    Lauermann, M.; Weimann, C.; Palmer, R.; Schindler, P. C.; Koeber, S.; Freude, W. Koos, C.; Rembe, C.

    2014-05-27

    We demonstrate a waveguide-based frequency shifter on the silicon photonic platform, enabling frequency shifts up to 10 GHz. The device is realized by silicon-organic hybrid (SOH) integration. Temporal shaping of the drive signal allows the suppression of spurious side-modes by more than 23 dB.

  19. Conceptual Integration of Hybridization by Algerian Students Intending to Teach Physical Sciences

    ERIC Educational Resources Information Center

    Salah, Hazzi; Dumon, Alain

    2011-01-01

    This work aims to assess the difficulties encountered by students of the Ecole Normale Superieure of Kouba (Algeria) intending to teach physical science in the integration of the hybridization of atomic orbitals. It is a concept that they should use in describing the formation of molecular orbitals ([sigma] and [pi]) in organic chemistry and gaps…

  20. noloco: An efficient implementation of van der Waals density functionals based on a Monte-Carlo integration technique

    PubMed Central

    Nabok, Dmitrii; Puschnig, Peter; Ambrosch-Draxl, Claudia

    2011-01-01

    The treatment of van der Waals interactions in density functional theory is an important field of ongoing research. Among different approaches developed recently to capture these non-local interactions, the van der Waals density functional (vdW-DF) developed in the groups of Langreth and Lundqvist is becoming increasingly popular. It does not rely on empirical parameters, and has been successfully applied to molecules, surface systems, and weakly-bound solids. As the vdW-DF requires the evaluation of a six-dimensional integral, it scales, however, unfavorably with system size. In this work, we present a numerically efficient implementation based on the Monte-Carlo technique for multi-dimensional integration. It can handle different versions of vdW-DF. Applications range from simple dimers to complex structures such as molecular crystals and organic molecules physisorbed on metal surfaces. PMID:21822326

  1. Engineering three-dimensional hybrid supercapacitors and microsupercapacitors for high-performance integrated energy storage.

    PubMed

    El-Kady, Maher F; Ihns, Melanie; Li, Mengping; Hwang, Jee Youn; Mousavi, Mir F; Chaney, Lindsay; Lech, Andrew T; Kaner, Richard B

    2015-04-01

    Supercapacitors now play an important role in the progress of hybrid and electric vehicles, consumer electronics, and military and space applications. There is a growing demand in developing hybrid supercapacitor systems to overcome the energy density limitations of the current generation of carbon-based supercapacitors. Here, we demonstrate 3D high-performance hybrid supercapacitors and microsupercapacitors based on graphene and MnO2 by rationally designing the electrode microstructure and combining active materials with electrolytes that operate at high voltages. This results in hybrid electrodes with ultrahigh volumetric capacitance of over 1,100 F/cm(3). This corresponds to a specific capacitance of the constituent MnO2 of 1,145 F/g, which is close to the theoretical value of 1,380 F/g. The energy density of the full device varies between 22 and 42 Wh/l depending on the device configuration, which is superior to those of commercially available double-layer supercapacitors, pseudocapacitors, lithium-ion capacitors, and hybrid supercapacitors tested under the same conditions and is comparable to that of lead acid batteries. These hybrid supercapacitors use aqueous electrolytes and are assembled in air without the need for expensive "dry rooms" required for building today's supercapacitors. Furthermore, we demonstrate a simple technique for the fabrication of supercapacitor arrays for high-voltage applications. These arrays can be integrated with solar cells for efficient energy harvesting and storage systems. PMID:25831542

  2. Engineering three-dimensional hybrid supercapacitors and microsupercapacitors for high-performance integrated energy storage

    PubMed Central

    El-Kady, Maher F.; Ihns, Melanie; Li, Mengping; Hwang, Jee Youn; Mousavi, Mir F.; Chaney, Lindsay; Lech, Andrew T.; Kaner, Richard B.

    2015-01-01

    Supercapacitors now play an important role in the progress of hybrid and electric vehicles, consumer electronics, and military and space applications. There is a growing demand in developing hybrid supercapacitor systems to overcome the energy density limitations of the current generation of carbon-based supercapacitors. Here, we demonstrate 3D high-performance hybrid supercapacitors and microsupercapacitors based on graphene and MnO2 by rationally designing the electrode microstructure and combining active materials with electrolytes that operate at high voltages. This results in hybrid electrodes with ultrahigh volumetric capacitance of over 1,100 F/cm3. This corresponds to a specific capacitance of the constituent MnO2 of 1,145 F/g, which is close to the theoretical value of 1,380 F/g. The energy density of the full device varies between 22 and 42 Wh/l depending on the device configuration, which is superior to those of commercially available double-layer supercapacitors, pseudocapacitors, lithium-ion capacitors, and hybrid supercapacitors tested under the same conditions and is comparable to that of lead acid batteries. These hybrid supercapacitors use aqueous electrolytes and are assembled in air without the need for expensive “dry rooms” required for building today’s supercapacitors. Furthermore, we demonstrate a simple technique for the fabrication of supercapacitor arrays for high-voltage applications. These arrays can be integrated with solar cells for efficient energy harvesting and storage systems. PMID:25831542

  3. Mercedes–Benz water molecules near hydrophobic wall: Integral equation theories vs Monte Carlo simulations

    PubMed Central

    Urbic, T.; Holovko, M. F.

    2011-01-01

    Associative version of Henderson-Abraham-Barker theory is applied for the study of Mercedes–Benz model of water near hydrophobic surface. We calculated density profiles and adsorption coefficients using Percus-Yevick and soft mean spherical associative approximations. The results are compared with Monte Carlo simulation data. It is shown that at higher temperatures both approximations satisfactory reproduce the simulation data. For lower temperatures, soft mean spherical approximation gives good agreement at low and at high densities while in at mid range densities, the prediction is only qualitative. The formation of a depletion layer between water and hydrophobic surface was also demonstrated and studied. PMID:21992334

  4. Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop.

    PubMed

    Sali, Andrej; Berman, Helen M; Schwede, Torsten; Trewhella, Jill; Kleywegt, Gerard; Burley, Stephen K; Markley, John; Nakamura, Haruki; Adams, Paul; Bonvin, Alexandre M J J; Chiu, Wah; Peraro, Matteo Dal; Di Maio, Frank; Ferrin, Thomas E; Grünewald, Kay; Gutmanas, Aleksandras; Henderson, Richard; Hummer, Gerhard; Iwasaki, Kenji; Johnson, Graham; Lawson, Catherine L; Meiler, Jens; Marti-Renom, Marc A; Montelione, Gaetano T; Nilges, Michael; Nussinov, Ruth; Patwardhan, Ardan; Rappsilber, Juri; Read, Randy J; Saibil, Helen; Schröder, Gunnar F; Schwieters, Charles D; Seidel, Claus A M; Svergun, Dmitri; Topf, Maya; Ulrich, Eldon L; Velankar, Sameer; Westbrook, John D

    2015-07-01

    Structures of biomolecular systems are increasingly computed by integrative modeling that relies on varied types of experimental data and theoretical information. We describe here the proceedings and conclusions from the first wwPDB Hybrid/Integrative Methods Task Force Workshop held at the European Bioinformatics Institute in Hinxton, UK, on October 6 and 7, 2014. At the workshop, experts in various experimental fields of structural biology, experts in integrative modeling and visualization, and experts in data archiving addressed a series of questions central to the future of structural biology. How should integrative models be represented? How should the data and integrative models be validated? What data should be archived? How should the data and models be archived? What information should accompany the publication of integrative models? PMID:26095030

  5. Hybrid III-V on silicon lasers for photonic integrated circuits on silicon

    NASA Astrophysics Data System (ADS)

    Duan, Guang-Hua; Jany, Christophe; Le Liepvre, Alban; Accard, Alain; Lamponi, Marco; Make, Dalila; Kaspar, Peter; Levaufre, Guillaume; Girard, Nils; Lelarge, François; Fedeli, Jean-Marc; Messaoudene, Sonia; Bordel, Damien; Olivier, Segolene

    2014-02-01

    Silicon photonics is attracting large attention due to the promise of fabricating low-cost, compact circuits that integrate photonic and microelectronic elements. It can address a wide range of applications from short distance data communication to long haul optical transmission. Today, practical Si-based light sources are still missing, despite the recent demonstration of an optically pumped germanium laser. This situation has driven research to the heterogeneous integration of III-V semiconductors on silicon through wafer bonding techniques. This paper reports on recent advances on integrated hybrid InP/SOI lasers and transmitters using a wafer bonding technique made in particular at III-V Lab, France.

  6. Draft of M2 Report on Integration of the Hybrid Hydride Model into INL's MBM Framework for Review

    SciTech Connect

    Tikare, Veena; Weck, Philippe F.; Schultz, Peter A.; Clark, Blythe; Glazoff, Michael; Homer, Eric

    2014-07-01

    This report documents the development, demonstration and validation of a mesoscale, microstructural evolution model for simulation of zirconium hydride {delta}-ZrH{sub 1.5} precipitation in the cladding of used nuclear fuels that may occur during long-term dry storage. While the Zr-based claddings are manufactured free of any hydrogen, they absorb hydrogen during service, in the reactor by a process commonly termed ‘hydrogen pick-up’. The precipitation and growth of zirconium hydrides during dry storage is one of the most likely fuel rod integrity failure mechanisms either by embrittlement or delayed hydride cracking of the cladding. While the phenomenon is well documented and identified as a potential key failure mechanism during long-term dry storage (NUREG/CR-7116), the ability to actually predict the formation of hydrides is poor. The model being documented in this work is a computational capability for the prediction of hydride formation in different claddings of used nuclear fuels. This work supports the Used Fuel Disposition Research and Development Campaign in assessing the structural engineering performance of the cladding during and after long-term dry storage. This document demonstrates a basic hydride precipitation model that is built on a recently developed hybrid Potts-phase field model that combines elements of Potts-Monte Carlo and the phase-field models. The model capabilities are demonstrated along with the incorporation of the starting microstructure, thermodynamics of the Zr-H system and the hydride formation mechanism.

  7. Integration of gene amplification and capillary gel electrophoresis on a polydimethylsiloxane-glass hybrid microchip.

    PubMed

    Hong, J W; Fujii, T; Seki, M; Yamamoto, T; Endo, I

    2001-01-01

    We report on the development of a hybrid polydimethylsiloxane (PDMS)-glass microchip for genetic analysis by functional integration of polymerase chain reaction (PCR) and capillary gel electrophoresis (CGE), and on related temperature control systems for PCR on a PDMS-glass hybrid microchip. The microchip was produced by molding PDMS against a microfabricated master with comparatively simple and inexpensive methods. PCR was successfully carried out on the PDMS-glass hybrid microchip with 500 bp target of lambdaDNA and the amplified gene was subsequently analyzed by CGE on the same PDMS-glass microchip. The chip could be considered as an inexpensive single-use apparatus compared to glass or silicon-made microchips for the same purpose. PMID:11288901

  8. Mercury + VisIt: Integration of a Real-Time Graphical Analysis Capability into a Monte Carlo Transport Code

    SciTech Connect

    O'Brien, M J; Procassini, R J; Joy, K I

    2009-03-09

    Validation of the problem definition and analysis of the results (tallies) produced during a Monte Carlo particle transport calculation can be a complicated, time-intensive processes. The time required for a person to create an accurate, validated combinatorial geometry (CG) or mesh-based representation of a complex problem, free of common errors such as gaps and overlapping cells, can range from days to weeks. The ability to interrogate the internal structure of a complex, three-dimensional (3-D) geometry, prior to running the transport calculation, can improve the user's confidence in the validity of the problem definition. With regard to the analysis of results, the process of extracting tally data from printed tables within a file is laborious and not an intuitive approach to understanding the results. The ability to display tally information overlaid on top of the problem geometry can decrease the time required for analysis and increase the user's understanding of the results. To this end, our team has integrated VisIt, a parallel, production-quality visualization and data analysis tool into Mercury, a massively-parallel Monte Carlo particle transport code. VisIt provides an API for real time visualization of a simulation as it is running. The user may select which plots to display from the VisIt GUI, or by sending VisIt a Python script from Mercury. The frequency at which plots are updated can be set and the user can visualize the simulation results as it is running.

  9. Quantum effects in a free-standing graphene lattice: Path-integral against classical Monte Carlo simulations

    NASA Astrophysics Data System (ADS)

    Brito, B. G. A.; Cândido, Ladir; Hai, G.-Q.; Peeters, F. M.

    2015-11-01

    In order to study quantum effects in a two-dimensional crystal lattice of a free-standing monolayer graphene, we have performed both path-integral Monte Carlo (PIMC) and classical Monte Carlo (MC) simulations for temperatures up to 2000 K. The REBO potential is used for the interatomic interaction. The total energy, interatomic distance, root-mean-square displacement of the atom vibrations, and the free energy of the graphene layer are calculated. The obtained lattice vibrational energy per atom from the classical MC simulation is very close to the energy of a three-dimensional harmonic oscillator 3 kBT . The PIMC simulation shows that quantum effects due to zero-point vibrations are significant for temperatures T <1000 K. The quantum contribution to the lattice vibrational energy becomes larger than that of the classical lattice for T <400 K. The lattice expansion due to the zero-point motion causes an increase of 0.53% in the lattice parameter. A minimum in the lattice parameter appears at T ≃500 K. Quantum effects on the atomic vibration amplitude of the graphene lattice and its free energy are investigated.

  10. Integrated Plasma Simulation of Lower Hybrid Current Drive in Tokamaks

    NASA Astrophysics Data System (ADS)

    Bonoli, P. T.; Wright, J. C.; Harvey, R. W.; Batchelor, D. B.; Berry, L. A.; Kessel, C. E.; Jardin, S. C.

    2012-03-01

    It has been shown in Alcator C-Mod that the onset time for sawteeth can be delayed significantly (up to 0.5 s) relative to ohmically heated plasmas, through the injection of off-axis LH current drive power [1]. We are simulating these experiments using the Integrated Plasma Simulator (IPS) [2], where the driven LH current density profiles are computed using a ray tracing component (GENRAY) and Fokker Planck code (CQL3D) [3] that are run in a tightly coupled time advance. The background plasma is evolved using the TSC transport code with the Porcelli sawtooth model [4]. Predictions of the driven LH current profiles will be compared with simpler ``reduced'' models for LHCD such as the LSC code which is implemented in TSC and which is also invoked within the IPS. [4pt] [1] C. E. Kessel et al, Bull. of the Am. Phys. Soc. 53, Poster PP6.00074 (2008). [0pt] [2] D. Batchelor et al, Journal of Physics: Conf. Series 125, 012039 (2008). [0pt] [3] R. W. Harvey and M. G. McCoy, Proc. of the IAEA Tech. Comm. Meeting on Simulation and Modeling of Therm. Plasmas, Montreal, Canada (1992). [0pt] [4] S. C. Jardin et al, J. Comp. Phys. 66, 481 (1986).

  11. Optimization of hybrid antireflection structure integrating surface texturing and multi-layer interference coating

    NASA Astrophysics Data System (ADS)

    Kubota, Shigeru; Kanomata, Kensaku; Suzuki, Takahiko; Hirose, Fumihiko

    2014-10-01

    The antireflection structure (ARS) for solar cells is categorized to mainly two different techniques, i.e., the surface texturing and the single or multi-layer antireflection interference coating. In this study, we propose a novel hybrid ARS, which integrates moth eye texturing and multi-layer coat, for application to organic photovoltaics (OPVs). Using optical simulations based on the finite-difference time-domain (FDTD) method, we conduct nearly global optimization of the geometric parameters characterizing the hybrid ARS. The proposed optimization algorithm consists of two steps: in the first step, we optimize the period and height of moth eye array, in the absence of multi-layer coating. In the second step, we optimize the whole structure of hybrid ARS by using the solution obtained by the first step as the starting search point. The methods of the simple grid search and the Hooke and Jeeves pattern search are used for global and local searches, respectively. In addition, we study the effects of deviations in the geometric parameters of hybrid ARS from their optimized values. The design concept of hybrid ARS is highly beneficial for broadband light trapping in OPVs.

  12. Development of Path Integral Monte Carlo Simulations with Localized Nodal Surfaces for Second-Row Elements.

    PubMed

    Militzer, Burkhard; Driver, Kevin P

    2015-10-23

    We extend the applicability range of fermionic path integral Monte Carlo simulations to heavier elements and lower temperatures by introducing various localized nodal surfaces. Hartree-Fock nodes yield the most accurate prediction for pressure and internal energy, which we combine with the results from density functional molecular dynamics simulations to obtain a consistent equation of state for hot, dense silicon under plasma conditions and in the regime of warm dense matter (2.3-18.6  g cm(-3), 5.0×10(5)-1.3×10(8)  K). The shock Hugoniot curve is derived and the structure of the fluid is characterized with various pair correlation functions. PMID:26551129

  13. Path-Integral Monte Carlo Study on a Droplet of a Dipolar Bose–Einstein Condensate Stabilized by Quantum Fluctuation

    NASA Astrophysics Data System (ADS)

    Saito, Hiroki

    2016-05-01

    Motivated by recent experiments [H. Kadau et al., Nature (London) 530, 194 (2016); I. Ferrier-Barbut et al., arXiv:1601.03318] and theoretical prediction (F. Wächtler and L. Santos, arXiv:1601.04501), the ground state of a dysprosium Bose–Einstein condensate with strong dipole–dipole interaction is studied by the path-integral Monte Carlo method. It is shown that quantum fluctuation can stabilize the condensate against dipolar collapse.

  14. Rapid microarray processing using a disposable hybridization chamber with an integrated micropump.

    PubMed

    Rupp, Jochen; Schmidt, Manuela; Münch, Susanne; Cavalar, Markus; Steller, Ulf; Steigert, Jürgen; Stumber, Michael; Dorrer, Christian; Rothacher, Peter; Zengerle, Roland; Daub, Martina

    2012-04-01

    We present a disposable microarray hybridization chamber with an integrated micropump to speed up diffusion based reaction kinetics by generating convective flow. The time-to-result for the hybridization reaction was reduced from 60 min (standard protocol) down to 15 min for a commercially available microarray. The integrated displacement micropump is pneumatically actuated. It includes two active microvalves and is designed for low-cost, high volume manufacturing. The setup is made out of two microstructured polymer parts realized in polycarbonate (PC) separated by a 25 μm thermoplastic elastomer (TPE) membrane. Pump rate can be controlled between 0.3 μl s(-1) and 5.7 μl s(-1) at actuation frequencies between 0.2 Hz and 8.0 Hz, respectively. PMID:22361890

  15. The hybrid photonic planar integrated receiver with a polymer optical waveguide

    NASA Astrophysics Data System (ADS)

    Busek, Karel; Jerbek, Vitezslav; Armas Arciniega, Julio; Prajzler, Vclav

    2008-11-01

    This article describes design of the photonic receiver composed of the system polymer planar waveguides, InGaAs p-i-n photodiode and integrated HBT amplifier on a low loss composite substrate. The photonic receiver was the main part of the hybrid integrated microwave optoelectronic transceiver TRx (transciever TRx) for the optical networks PON (passive optical networks) with FTTH (fiber-to-the-home) topology. In this article are presented the research results of threedimensional field between output facet of a optical waveguide and p-i-n photodiode. In terms of our research, there was optimized the optical coupling among the facet waveguide and pi-n photodiode and the electrical coupling among p-i-n photodiode and input of HBT amplifier. The hybrid planar lightwave circuit (PLC) of the transceiver TRx will be composed from a two parts - polymer optical waveguide including VHGT filter section and a optoelectronic microwave section.

  16. hybrid\\scriptsize{{MANTIS}}: a CPU-GPU Monte Carlo method for modeling indirect x-ray detectors with columnar scintillators

    NASA Astrophysics Data System (ADS)

    Sharma, Diksha; Badal, Andreu; Badano, Aldo

    2012-04-01

    The computational modeling of medical imaging systems often requires obtaining a large number of simulated images with low statistical uncertainty which translates into prohibitive computing times. We describe a novel hybrid approach for Monte Carlo simulations that maximizes utilization of CPUs and GPUs in modern workstations. We apply the method to the modeling of indirect x-ray detectors using a new and improved version of the code \\scriptsize{{MANTIS}}, an open source software tool used for the Monte Carlo simulations of indirect x-ray imagers. We first describe a GPU implementation of the physics and geometry models in fast\\scriptsize{{DETECT}}2 (the optical transport model) and a serial CPU version of the same code. We discuss its new features like on-the-fly column geometry and columnar crosstalk in relation to the \\scriptsize{{MANTIS}} code, and point out areas where our model provides more flexibility for the modeling of realistic columnar structures in large area detectors. Second, we modify \\scriptsize{{PENELOPE}} (the open source software package that handles the x-ray and electron transport in \\scriptsize{{MANTIS}}) to allow direct output of location and energy deposited during x-ray and electron interactions occurring within the scintillator. This information is then handled by optical transport routines in fast\\scriptsize{{DETECT}}2. A load balancer dynamically allocates optical transport showers to the GPU and CPU computing cores. Our hybrid\\scriptsize{{MANTIS}} approach achieves a significant speed-up factor of 627 when compared to \\scriptsize{{MANTIS}} and of 35 when compared to the same code running only in a CPU instead of a GPU. Using hybrid\\scriptsize{{MANTIS}}, we successfully hide hours of optical transport time by running it in parallel with the x-ray and electron transport, thus shifting the computational bottleneck from optical to x-ray transport. The new code requires much less memory than \\scriptsize{{MANTIS}} and, as a result, allows us to efficiently simulate large area detectors.

  17. Effects of relative positioning of energy sources on weld integrity for hybrid laser arc welding

    NASA Astrophysics Data System (ADS)

    Liu, Shuangyu; Li, Yanqing; Liu, Fengde; Zhang, Hong; Ding, Hongtao

    2016-06-01

    This study is concerned with the effects of laser and arc arrangement on weld integrity for the hybrid laser arc welding processes. Experiments were conducted for a high-strength steel using a 4 kW Nd: YAG laser and a metal active gas (MAG) welding facility under two configurations of arc-laser hybrid welding (ALHW) and laser-arc hybrid welding (LAHW). Metallographic analysis and mechanical testing were performed to evaluate the weld integrity in terms of weld bead geometry, microstructure and mechanical properties. The morphology of the weld bead cross-section was studied and the typical macrostructure of the weld beads appeared to be cone-shaped and cocktail cup-shaped under ALHW and LAHW configurations, respectively. The weld integrity attributes of microstructure, phase constituents and microhardness were analyzed for different weld regions. The tensile and impact tests were performed and fracture surface morphology was analyzed by scanning electron microscope. The study showed that ALHW produced joints with a better weld shape and a more uniform microstructure of lath martensite, while LAHW weld had a heterogeneous structure of lath martensite and austenite.

  18. Broadband silicon optical modulator using a graphene-integrated hybrid plasmonic waveguide.

    PubMed

    Shin, Jin-Soo; Kim, Jin Tae

    2015-09-11

    Graphene is an excellent electronic and photonic material for developing electronic-photonic integrated circuits in Si-based semiconductor devices with ultra wide operational bandwidth. As an extended application, here we propose a broadband silicon optical modulator using a graphene-integrated hybrid plasmonic waveguide, and investigate the optical characteristics numerically at a wavelength of 1.55 μm. The optical device is based on the surface plasmon polariton absorption of graphene. By electrically tuning the graphene's refractive index as low as that of a noble metal, the hybrid plasmonic waveguide supports a strongly confined highly lossy hybrid long-range surface plasmon polariton strip mode, and hence light coupled from an input waveguide experiences significant power attenuation as it propagates along the waveguide. Over the entire C-band from 1.530 to 1.565 μm wavelengths, the on/off extinction ratio is larger than 13.7 dB. This modulator has the potential to play a key role in realizing graphene-Si waveguide-based integrated photonic devices. PMID:26293975

  19. Broadband silicon optical modulator using a graphene-integrated hybrid plasmonic waveguide

    NASA Astrophysics Data System (ADS)

    Shin, Jin-Soo; Kim, Jin Tae

    2015-09-01

    Graphene is an excellent electronic and photonic material for developing electronic-photonic integrated circuits in Si-based semiconductor devices with ultra wide operational bandwidth. As an extended application, here we propose a broadband silicon optical modulator using a graphene-integrated hybrid plasmonic waveguide, and investigate the optical characteristics numerically at a wavelength of 1.55 μm. The optical device is based on the surface plasmon polariton absorption of graphene. By electrically tuning the graphene’s refractive index as low as that of a noble metal, the hybrid plasmonic waveguide supports a strongly confined highly lossy hybrid long-range surface plasmon polariton strip mode, and hence light coupled from an input waveguide experiences significant power attenuation as it propagates along the waveguide. Over the entire C-band from 1.530 to 1.565 μm wavelengths, the on/off extinction ratio is larger than 13.7 dB. This modulator has the potential to play a key role in realizing graphene-Si waveguide-based integrated photonic devices.

  20. An integrated hybrid system for genetic analysis combining EWOD sample preparation and magnetic detection

    NASA Astrophysics Data System (ADS)

    Brennan, Des; Jary, Dorothee; Peponnet, Christine; Cardosa, Filipe; Freitas, Paolo; Dinca, Mihai; Aherne, Margaret; Galvin, Paul

    2011-08-01

    Over the last decade microelectronic technologies have delivered significant advances in devices for point of care diagnostics. Complex microfluidic systems integrate components such as valves, pumps etc. to manipulate liquids. In recent years, the drive is to combine biochemical protocols in a single system, delivering "sample in answer out". An Electrowetting on Dielectric (EWOD) device offers the possibility to move and manipulate 64nl volumes implementing biochemical processes, while the magnetic sensor facilitates hybridisation detection. We outline an injection molding approach where EWOD and magnetic devices are integrated into a hybrid microfluidic system with the potential to implement "sample in answer out" biological protocols.

  1. Monte Carlo ray-tracing simulations of luminescent solar concentrators for building integrated photovoltaics

    NASA Astrophysics Data System (ADS)

    Leow, Shin Woei; Corrado, Carley; Osborn, Melissa; Carter, Sue A.

    2013-09-01

    Luminescent solar concentrators (LSCs) have the ability to receive light from a wide range of angles, concentrating the captured light onto small photo active areas. This enables greater incorporation of LSCs into building designs as windows, skylights and wall claddings in addition to rooftop installations of current solar panels. Using relatively cheap luminescent dyes and acrylic waveguides to effect light concentration onto lesser photovoltaic (PV) cells, there is potential for this technology to approach grid price parity. We employ a panel design in which the front facing PV cells collect both direct and concentrated light ensuring a gain factor greater than one. This also allows for flexibility in determining the placement and percentage coverage of PV cells during the design process to balance reabsorption losses against the power output and level of light concentration desired. To aid in design optimization, a Monte-Carlo ray tracing program was developed to study the transport of photons and loss mechanisms in LSC panels. The program imports measured absorption/emission spectra and transmission coefficients as simulation parameters with interactions of photons in the panel determined by comparing calculated probabilities with random number generators. LSC panels with multiple dyes or layers can also be simulated. Analysis of the results reveals optimal panel dimensions and PV cell layouts for maximum power output for a given dye concentration, absorbtion/emission spectrum and quantum efficiency.

  2. ITS Version 6 : the integrated TIGER series of coupled electron/photon Monte Carlo transport codes.

    SciTech Connect

    Franke, Brian Claude; Kensek, Ronald Patrick; Laub, Thomas William

    2008-04-01

    ITS is a powerful and user-friendly software package permitting state-of-the-art Monte Carlo solution of lineartime-independent coupled electron/photon radiation transport problems, with or without the presence of macroscopic electric and magnetic fields of arbitrary spatial dependence. Our goal has been to simultaneously maximize operational simplicity and physical accuracy. Through a set of preprocessor directives, the user selects one of the many ITS codes. The ease with which the makefile system is applied combines with an input scheme based on order-independent descriptive keywords that makes maximum use of defaults and internal error checking to provide experimentalists and theorists alike with a method for the routine but rigorous solution of sophisticated radiation transport problems. Physical rigor is provided by employing accurate cross sections, sampling distributions, and physical models for describing the production and transport of the electron/photon cascade from 1.0 GeV down to 1.0 keV. The availability of source code permits the more sophisticated user to tailor the codes to specific applications and to extend the capabilities of the codes to more complex applications. Version 6, the latest version of ITS, contains (1) improvements to the ITS 5.0 codes, and (2) conversion to Fortran 90. The general user friendliness of the software has been enhanced through memory allocation to reduce the need for users to modify and recompile the code.

  3. Advances in hybrid finite element - boundary integral - multilevel fast multipole - uniform geometrical theory of diffraction method

    NASA Astrophysics Data System (ADS)

    Tzoulis, A.; Eibert, T. F.

    2007-06-01

    Numerical modeling of problems including composite metallic/dielectric objects with arbitrary shapes and electrically large conducting objects within a common environment is performed in an optimum way with the recently developed powerful hybrid numerical method, which combines the Finite Element Boundary Integral (FEBI) method and the Multilevel Fast Multipole Method (MLFMM) with the Uniform Geometrical Theory of Diffraction (UTD), giving full electromagnetic coupling between all involved objects. In this contribution, the hybrid FEBI-MLFMM-UTD method is extended to double diffracted fields on pairs of straight metallic edges, formulated with the hard and soft scalar diffraction coefficients of UTD. The diffraction points on each pair of edges are determined by an iterative three-dimensional parametric realization of the generalized Fermat's principle. The divergence factor of the double diffracted field is computed by multiplying the appropriate divergence factors of the single diffracted UTD fields on each edge for the particular case. Thereby, the ray caustic distance of the diffracted field at the second edge is determined by linear interpolation between the radii of curvature in the two principal planes of the incident astigmatic ray tube. Further, fast near-field computation in the postprocessing stage of the hybrid method is extended in each translation domain to ray optical contributions due to the presence of electrically large objects, according to the hybridization of MLFMM with UTD. Formulations and numerical results will be presented.

  4. Quantum partition functions of composite particles in a hydrogen-helium plasma via path integral Monte Carlo

    SciTech Connect

    Wendland, D.; Ballenegger, V.; Alastuey, A.

    2014-11-14

    We compute two- and three-body cluster functions that describe contributions of composite entities, like hydrogen atoms, ions H{sup −}, H{sub 2}{sup +}, and helium atoms, and also charge-charge and atom-charge interactions, to the equation of state of a hydrogen-helium mixture at low density. A cluster function has the structure of a truncated virial coefficient and behaves, at low temperatures, like a usual partition function for the composite entity. Our path integral Monte Carlo calculations use importance sampling to sample efficiently the cluster partition functions even at low temperatures where bound state contributions dominate. We also employ a new and efficient adaptive discretization scheme that allows one not only to eliminate Coulomb divergencies in discretized path integrals, but also to direct the computational effort where particles are close and thus strongly interacting. The numerical results for the two-body function agree with the analytically known quantum second virial coefficient. The three-body cluster functions are compared at low temperatures with familiar partition functions for composite entities.

  5. Extraction of diffuse correlation spectroscopy flow index by integration of Nth-order linear model with Monte Carlo simulation

    NASA Astrophysics Data System (ADS)

    Shang, Yu; Li, Ting; Chen, Lei; Lin, Yu; Toborek, Michal; Yu, Guoqiang

    2014-05-01

    Conventional semi-infinite solution for extracting blood flow index (BFI) from diffuse correlation spectroscopy (DCS) measurements may cause errors in estimation of BFI (αDB) in tissues with small volume and large curvature. We proposed an algorithm integrating Nth-order linear model of autocorrelation function with the Monte Carlo simulation of photon migrations in tissue for the extraction of αDB. The volume and geometry of the measured tissue were incorporated in the Monte Carlo simulation, which overcome the semi-infinite restrictions. The algorithm was tested using computer simulations on four tissue models with varied volumes/geometries and applied on an in vivo stroke model of mouse. Computer simulations shows that the high-order (N ≥ 5) linear algorithm was more accurate in extracting αDB (errors < ±2%) from the noise-free DCS data than the semi-infinite solution (errors: -5.3% to -18.0%) for different tissue models. Although adding random noises to DCS data resulted in αDB variations, the mean values of errors in extracting αDB were similar to those reconstructed from the noise-free DCS data. In addition, the errors in extracting the relative changes of αDB using both linear algorithm and semi-infinite solution were fairly small (errors < ±2.0%) and did not rely on the tissue volume/geometry. The experimental results from the in vivo stroke mice agreed with those in simulations, demonstrating the robustness of the linear algorithm. DCS with the high-order linear algorithm shows the potential for the inter-subject comparison and longitudinal monitoring of absolute BFI in a variety of tissues/organs with different volumes/geometries.

  6. Extraction of diffuse correlation spectroscopy flow index by integration of Nth-order linear model with Monte Carlo simulation

    SciTech Connect

    Shang, Yu; Lin, Yu; Yu, Guoqiang; Li, Ting; Chen, Lei; Toborek, Michal

    2014-05-12

    Conventional semi-infinite solution for extracting blood flow index (BFI) from diffuse correlation spectroscopy (DCS) measurements may cause errors in estimation of BFI (αD{sub B}) in tissues with small volume and large curvature. We proposed an algorithm integrating Nth-order linear model of autocorrelation function with the Monte Carlo simulation of photon migrations in tissue for the extraction of αD{sub B}. The volume and geometry of the measured tissue were incorporated in the Monte Carlo simulation, which overcome the semi-infinite restrictions. The algorithm was tested using computer simulations on four tissue models with varied volumes/geometries and applied on an in vivo stroke model of mouse. Computer simulations shows that the high-order (N ≥ 5) linear algorithm was more accurate in extracting αD{sub B} (errors < ±2%) from the noise-free DCS data than the semi-infinite solution (errors: −5.3% to −18.0%) for different tissue models. Although adding random noises to DCS data resulted in αD{sub B} variations, the mean values of errors in extracting αD{sub B} were similar to those reconstructed from the noise-free DCS data. In addition, the errors in extracting the relative changes of αD{sub B} using both linear algorithm and semi-infinite solution were fairly small (errors < ±2.0%) and did not rely on the tissue volume/geometry. The experimental results from the in vivo stroke mice agreed with those in simulations, demonstrating the robustness of the linear algorithm. DCS with the high-order linear algorithm shows the potential for the inter-subject comparison and longitudinal monitoring of absolute BFI in a variety of tissues/organs with different volumes/geometries.

  7. A hybrid method for solving time-domain integral equations in transient scattering

    NASA Astrophysics Data System (ADS)

    Tijhuis, A. G.; Wiemans, R.; Kuester, E. F.

    A new hybrid method is proposed for the numerical solution of integral equations describing transient scattering problems. The basic idea behind the method is to first discretize in space, and then solve the resulting system of linear time-domain equations by carrying out a temporal Laplace transformation. This approach combines the efficiency of the marching-on-in-time method with the stability and the accuracy of frequency-domain techniques. Numerical results are presented for the scattering of E-polarized, pulsed waves by a one-dimensionally inhomogeneous, lossy dielectric slab located in between two homogeneous, lossless dielectric half-spaces, and by a radially inhomogeneous, lossy dielectric circular cylinder embedded in vacuum. For these problems, the hybrid method turns out to be more powerful than existing solution techniques.

  8. Performance analysis of an OTEC plant and a desalination plant using an integrated hybrid cycle

    SciTech Connect

    Uehara, Haruo; Miyara, Akio; Ikegami, Yasuyuki; Nakaoka, Tsutomu

    1996-05-01

    A performance analysis of an OTEC plant using an integrated hybrid cycle (I-H OTEC Cycle) has been conducted. The I-H OTEC cycle is a combination of a closed-cycle OTEC plant and a spray flash desalination plant. In an I-H OTEC cycle, warm sea water evaporates the liquid ammonia in the OTEC evaporator, then enters the flash chamber and evaporates itself. The evaporated steam enters the desalination condenser and is condensed by the cold sea water passed through the OTEC condenser. The optimization of the I-H OTEC cycle is analyzed by the method of steepest descent. The total heat transfer area of heat exchangers per net power is used as an objective function. Numerical results are reported for a 10 MW I-H OTEC cycle with plate-type heat exchangers and ammonia as working fluid. The results are compared with those of a joint hybrid OTEC cycle (J-H OTEC Cycle).

  9. A hybrid kinetic Monte Carlo method for simulating silicon films grown by plasma-enhanced chemical vapor deposition

    NASA Astrophysics Data System (ADS)

    Tsalikis, D. G.; Baig, C.; Mavrantzas, V. G.; Amanatides, E.; Mataras, D.

    2013-11-01

    We present a powerful kinetic Monte Carlo (KMC) algorithm that allows one to simulate the growth of nanocrystalline silicon by plasma enhanced chemical vapor deposition (PECVD) for film thicknesses as large as several hundreds of monolayers. Our method combines a standard n-fold KMC algorithm with an efficient Markovian random walk scheme accounting for the surface diffusive processes of the species involved in PECVD. These processes are extremely fast compared to chemical reactions, thus in a brute application of the KMC method more than 99% of the computational time is spent in monitoring them. Our method decouples the treatment of these events from the rest of the reactions in a systematic way, thereby dramatically increasing the efficiency of the corresponding KMC algorithm. It is also making use of a very rich kinetic model which includes 5 species (H, SiH3, SiH2, SiH, and Si2H5) that participate in 29 reactions. We have applied the new method in simulations of silicon growth under several conditions (in particular, silane fraction in the gas mixture), including those usually realized in actual PECVD technologies. This has allowed us to directly compare against available experimental data for the growth rate, the mesoscale morphology, and the chemical composition of the deposited film as a function of dilution ratio.

  10. A hybrid kinetic Monte Carlo method for simulating silicon films grown by plasma-enhanced chemical vapor deposition.

    PubMed

    Tsalikis, D G; Baig, C; Mavrantzas, V G; Amanatides, E; Mataras, D

    2013-11-28

    We present a powerful kinetic Monte Carlo (KMC) algorithm that allows one to simulate the growth of nanocrystalline silicon by plasma enhanced chemical vapor deposition (PECVD) for film thicknesses as large as several hundreds of monolayers. Our method combines a standard n-fold KMC algorithm with an efficient Markovian random walk scheme accounting for the surface diffusive processes of the species involved in PECVD. These processes are extremely fast compared to chemical reactions, thus in a brute application of the KMC method more than 99% of the computational time is spent in monitoring them. Our method decouples the treatment of these events from the rest of the reactions in a systematic way, thereby dramatically increasing the efficiency of the corresponding KMC algorithm. It is also making use of a very rich kinetic model which includes 5 species (H, SiH3, SiH2, SiH, and Si2H5) that participate in 29 reactions. We have applied the new method in simulations of silicon growth under several conditions (in particular, silane fraction in the gas mixture), including those usually realized in actual PECVD technologies. This has allowed us to directly compare against available experimental data for the growth rate, the mesoscale morphology, and the chemical composition of the deposited film as a function of dilution ratio. PMID:24289368

  11. Heterogeneous Biomedical Database Integration Using a Hybrid Strategy: A p53 Cantcer Research Database

    PubMed Central

    Bichutskiy, Vadim Y.; Colman, Richard; Brachmann, Rainer K.; Lathrop, Richard H.

    2006-01-01

    Complex problems in life science research give rise to multidisciplinary collaboration, and hence, to the need for heterogeneous database integration. The tumor suppressor p53 is mutated in close to 50% of human cancers, and a small drug-like molecule with the ability to restore native function to cancerous p53 mutants is a long-held medical goal of cancer treatment. The Cancer Research DataBase (CRDB) was designed in support of a project to find such small molecules. As a cancer informatics project, the CRDB involved small molecule data, computational docking results, functional assays, and protein structure data. As an example of the hybrid strategy for data integration, it combined the mediation and data warehousing approaches. This paper uses the CRDB to illustrate the hybrid strategy as a viable approach to heterogeneous data integration in biomedicine, and provides a design method for those considering similar systems. More efficient data sharing implies increased productivity, and, hopefully, improved chances of success in cancer research. (Code and database schemas are freely downloadable, http://www.igb.uci.edu/research/research.html.) PMID:19458771

  12. Sole means navigation and integrity through hybrid Loran-C and NAVSTAR GPS

    NASA Technical Reports Server (NTRS)

    Vangraas, Frank

    1990-01-01

    A sole means navigation system does not only call for integrity, but also for coverage, reliability, availability and accuracy. Even though ground monitored GPS will provide integrity, availability is still not sufficient. One satellite outage can affect a large service area for several hours per day. The same holds for differential GPS; a total satellite outage cannot be corrected for. To obtain sufficient coverage, extra measurements are needed, either in the form of extra GPS satellites (expensive) or through redundant measurements from other systems. LORAN-C is available and will, hybridized with GPS, result in a system that has the potential to satisfy the requirements for a sole means navigation system for use in the continental United States. Assumptions are made about the qualification sole means, mainly based on current sole means systems such as VOR/DME. In order to allow for system design that will satisfy sole means requirements, it is recommended that a definition of a sole means navigation system be established. This definition must include requirements for availability, reliability, and integrity currently not specified. In addition to the definition of a sole means navigation system, certification requirements must be established for hybrid navigation systems. This will allow for design and production of a new generation of airborne navigation systems that will reduce overall system costs and simplify training procedures.

  13. Integrated hybrid polystyrene-polydimethylsiloxane device for monitoring cellular release with microchip electrophoresis and electrochemical detection

    PubMed Central

    Johnson, Alicia S.; Mehl, Benjamin T.; Martin, R. Scott

    2015-01-01

    In this work, a polystyrene (PS)-polydimethylsiloxane (PDMS) hybrid device was developed to enable the integration of cell culture with analysis by microchip electrophoresis and electrochemical detection. It is shown that this approach combines the fundamental advantages of PDMS devices (the ability to integrate pumps and valves) and PS devices (the ability to permanently embed fluidic tubing and electrodes). The embedded fused-silica capillary enables high temporal resolution measurements from off-chip cell culture dishes and the embedded electrodes provide close to real-time analysis of small molecule neurotransmitters. A novel surface treatment for improved (reversible) adhesion between PS and PDMS is described using a chlorotrimethylsilane stamping method. It is demonstrated that a Pd decoupler is efficient at handling the high current (and cathodic hydrogen production) resulting from use of high ionic strength buffers needed for cellular analysis; thus allowing an electrophoretic separation and in-channel detection. The separation of norepinephrine (NE) and dopamine (DA) in highly conductive biological buffers was optimized using a mixed surfactant system. This PS-PDMS hybrid device integrates multiple processes including continuous sampling from a cell culture dish, on-chip pump and valving technologies, microchip electrophoresis, and electrochemical detection to monitor neurotransmitter release from PC 12 cells. PMID:25663849

  14. Integration of Multisensor Hybrid Reasoners to Support Personal Autonomy in the Smart Home

    PubMed Central

    Valero, Miguel Ángel; Bravo, José; Chamizo, Juan Manuel García; López-de-Ipiña, Diego

    2014-01-01

    The deployment of the Ambient Intelligence (AmI) paradigm requires designing and integrating user-centered smart environments to assist people in their daily life activities. This research paper details an integration and validation of multiple heterogeneous sensors with hybrid reasoners that support decision making in order to monitor personal and environmental data at a smart home in a private way. The results innovate on knowledge-based platforms, distributed sensors, connected objects, accessibility and authentication methods to promote independent living for elderly people. TALISMAN+, the AmI framework deployed, integrates four subsystems in the smart home: (i) a mobile biomedical telemonitoring platform to provide elderly patients with continuous disease management; (ii) an integration middleware that allows context capture from heterogeneous sensors to program environment's reaction; (iii) a vision system for intelligent monitoring of daily activities in the home; and (iv) an ontologies-based integrated reasoning platform to trigger local actions and manage private information in the smart home. The framework was integrated in two real running environments, the UPM Accessible Digital Home and MetalTIC house, and successfully validated by five experts in home care, elderly people and personal autonomy. PMID:25232910

  15. Integration of multisensor hybrid reasoners to support personal autonomy in the smart home.

    PubMed

    Valero, Miguel Ángel; Bravo, José; Chamizo, Juan Manuel García; López-de-Ipiña, Diego

    2014-01-01

    The deployment of the Ambient Intelligence (AmI) paradigm requires designing and integrating user-centered smart environments to assist people in their daily life activities. This research paper details an integration and validation of multiple heterogeneous sensors with hybrid reasoners that support decision making in order to monitor personal and environmental data at a smart home in a private way. The results innovate on knowledge-based platforms, distributed sensors, connected objects, accessibility and authentication methods to promote independent living for elderly people. TALISMAN+, the AmI framework deployed, integrates four subsystems in the smart home: (i) a mobile biomedical telemonitoring platform to provide elderly patients with continuous disease management; (ii) an integration middleware that allows context capture from heterogeneous sensors to program environment's reaction; (iii) a vision system for intelligent monitoring of daily activities in the home; and (iv) an ontologies-based integrated reasoning platform to trigger local actions and manage private information in the smart home. The framework was integrated in two real running environments, the UPM Accessible Digital Home and MetalTIC house, and successfully validated by five experts in home care, elderly people and personal autonomy. PMID:25232910

  16. lordif: An R Package for Detecting Differential Item Functioning Using Iterative Hybrid Ordinal Logistic Regression/Item Response Theory and Monte Carlo Simulations

    PubMed Central

    Choi, Seung W.; Gibbons, Laura E.; Crane, Paul K.

    2011-01-01

    Logistic regression provides a flexible framework for detecting various types of differential item functioning (DIF). Previous efforts extended the framework by using item response theory (IRT) based trait scores, and by employing an iterative process using group–specific item parameters to account for DIF in the trait scores, analogous to purification approaches used in other DIF detection frameworks. The current investigation advances the technique by developing a computational platform integrating both statistical and IRT procedures into a single program. Furthermore, a Monte Carlo simulation approach was incorporated to derive empirical criteria for various DIF statistics and effect size measures. For purposes of illustration, the procedure was applied to data from a questionnaire of anxiety symptoms for detecting DIF associated with age from the Patient–Reported Outcomes Measurement Information System. PMID:21572908

  17. Calculations of S values and effective dose for the radioiodine carrier and surrounding individuals based on Chinese hybrid reference phantoms using the Monte Carlo technique.

    PubMed

    Geng, Changran; Tang, Xiaobin; Qian, Wei; Guan, Fada; Johns, Jesse; Yu, Haiyan; Gong, Chunhui; Shu, Diyun; Chen, Da

    2015-09-01

    The S values for the thyroid as the radioiodine source organ to other target organs were investigated using Chinese hybrid reference phantoms and the Monte Carlo code MCNP5. Two radioiodine isotopes (125)I and (131)I uniformly distributed in the thyroid were investigated separately. We compared our S values for (131)I in Chinese phantoms with previous studies using other types of phantoms: Oak Ridge National Laboratory (ORNL) stylized phantoms, International Commission on Radiological Protection (ICRP) voxel phantoms, and University of Florida (UF) phantoms. Our results are much closer to the UF phantoms. For each specific target organ, the S value for (131)I is larger than for (125)I in both male and female phantoms. In addition, the S values and effective dose to surrounding face-to-face exposed individuals, including different genders and ages (10- and 15-year-old juniors, and adults) from an adult male radioiodine carrier were also investigated. The target organ S values and effective dose for surrounding individuals obey the inverse square law with the distance between source and target phantoms. The obtained effective dose data in Chinese phantoms are comparable to the results in a previous study using the UF phantoms. The data generated in this study can serve as the reference to make recommendations for radiation protection of the Chinese patients or nuclear workers. PMID:26344387

  18. Structural characterization of an immunoenhancing heteroglycan of a hybrid mushroom (pfls1h) of Pleurotus florida and Lentinus squarrosulus (Mont.) Singer.

    PubMed

    Sen, Ipsita K; Maji, Praloy K; Behera, Birendra; Mallick, Pijush; Maiti, Tapas K; Sikdar, Samir R; Islam, Syed S

    2013-04-19

    An immunostimulating water-soluble heteroglycan (PS-II) was isolated from an aqueous extract of the fruit bodies of a hybrid mushroom, pfls1h produced by intergeneric protoplast fusion between Pleurotus florida and Lentinus squarrosulus (Mont.) Singer. Structural characterization of PS-II was carried out using sugar analysis, methylation experiment, periodate oxidation and 1D/2D NMR studies. Sugar analysis indicated the presence of glucose, mannose and galactose in a molar ratio of 1:1:2. Methylation analysis revealed that PS-II was composed of (1→6)- and (1→2,4,6)-α-D-galactopyranosyl, terminal β-D-mannopyranosyl and terminal β-D-glucopyranosyl residues in a relative proportion of approximately 1:1:1:1. On the basis of chemical analysis and NMR studies, the structure of the repeating unit of the heteroglycan was established to consist of a backbone chain of two (1→6)-α-D-galactopyranosyl residues, one of which is branched at O-2 with terminal β-D-Manp and at O-4 with terminal β-D-Glcp. This heteroglycan (PS-II) showed in vitro splenocyte, thymocyte and macrophage activations. PMID:23500959

  19. SU-E-CAMPUS-I-02: Estimation of the Dosimetric Error Caused by the Voxelization of Hybrid Computational Phantoms Using Triangle Mesh-Based Monte Carlo Transport

    SciTech Connect

    Lee, C; Badal, A

    2014-06-15

    Purpose: Computational voxel phantom provides realistic anatomy but the voxel structure may result in dosimetric error compared to real anatomy composed of perfect surface. We analyzed the dosimetric error caused from the voxel structure in hybrid computational phantoms by comparing the voxel-based doses at different resolutions with triangle mesh-based doses. Methods: We incorporated the existing adult male UF/NCI hybrid phantom in mesh format into a Monte Carlo transport code, penMesh that supports triangle meshes. We calculated energy deposition to selected organs of interest for parallel photon beams with three mono energies (0.1, 1, and 10 MeV) in antero-posterior geometry. We also calculated organ energy deposition using three voxel phantoms with different voxel resolutions (1, 5, and 10 mm) using MCNPX2.7. Results: Comparison of organ energy deposition between the two methods showed that agreement overall improved for higher voxel resolution, but for many organs the differences were small. Difference in the energy deposition for 1 MeV, for example, decreased from 11.5% to 1.7% in muscle but only from 0.6% to 0.3% in liver as voxel resolution increased from 10 mm to 1 mm. The differences were smaller at higher energies. The number of photon histories processed per second in voxels were 6.4×10{sup 4}, 3.3×10{sup 4}, and 1.3×10{sup 4}, for 10, 5, and 1 mm resolutions at 10 MeV, respectively, while meshes ran at 4.0×10{sup 4} histories/sec. Conclusion: The combination of hybrid mesh phantom and penMesh was proved to be accurate and of similar speed compared to the voxel phantom and MCNPX. The lowest voxel resolution caused a maximum dosimetric error of 12.6% at 0.1 MeV and 6.8% at 10 MeV but the error was insignificant in some organs. We will apply the tool to calculate dose to very thin layer tissues (e.g., radiosensitive layer in gastro intestines) which cannot be modeled by voxel phantoms.

  20. Laser direct writing of inorganic-organic hybrid polymeric channel waveguide for optical integrated circuits

    NASA Astrophysics Data System (ADS)

    Wang, Shuping; Borden, Brad; Li, Ye; Goel, Prakhar

    2006-10-01

    A focused 375 nm laser diode module is used to fabricate optical channel waveguides on Si wafers using commercially available inorganic-organic hybrid polymers. The fabrication process eliminates all the complex steps associated with the definition of structures using photolithographic techniques, making rapid prototyping of integrated optic devices possible. Channel waveguides with smooth side-walls are fabricated and characterized. The losses, measured using cutback loss measurement method, are typically less than 1dB/cm, making them especially applicable to Si based optical interconnects applications.

  1. Progress of Integral Experiments in Benchmark Fission Assemblies for a Blanket of Hybrid Reactor

    NASA Astrophysics Data System (ADS)

    Liu, R.; Zhu, T. H.; Yan, X. S.; Lu, X. X.; Jiang, L.; Wang, M.; Han, Z. J.; Wen, Z. W.; Lin, J. F.; Yang, Y. W.

    2014-04-01

    This article describes recent progress in integral neutronics experiments in benchmark fission assemblies for the blanket design in a hybrid reactor. The spherical assemblies consist of three layers of depleted uranium shells and several layers of polyethylene shells, separately. In the assemblies with centralizing the D-T neutron source, the plutonium production rates, uranium fission rates and leakage neutron spectra are measured. The measured results are compared to the calculated ones with the MCNP-4B code and ENDF/B-VI library data, available.

  2. Accurate determination of the Gibbs energy of Cu-Zr melts using the thermodynamic integration method in Monte Carlo simulations.

    PubMed

    Harvey, J-P; Gheribi, A E; Chartrand, P

    2011-08-28

    The design of multicomponent alloys used in different applications based on specific thermo-physical properties determined experimentally or predicted from theoretical calculations is of major importance in many engineering applications. A procedure based on Monte Carlo simulations (MCS) and the thermodynamic integration (TI) method to improve the quality of the predicted thermodynamic properties calculated from classical thermodynamic calculations is presented in this study. The Gibbs energy function of the liquid phase of the Cu-Zr system at 1800 K has been determined based on this approach. The internal structure of Cu-Zr melts and amorphous alloys at different temperatures, as well as other physical properties were also obtained from MCS in which the phase trajectory was modeled by the modified embedded atom model formalism. A rigorous comparison between available experimental data and simulated thermo-physical properties obtained from our MCS is presented in this work. The modified quasichemical model in the pair approximation was parameterized using the internal structure data obtained from our MCS and the precise Gibbs energy function calculated at 1800 K from the TI method. The predicted activity of copper in Cu-Zr melts at 1499 K obtained from our thermodynamic optimization was corroborated by experimental data found in the literature. The validity of the amplitude of the entropy of mixing obtained from the in silico procedure presented in this work was analyzed based on the thermodynamic description of hard sphere mixtures. PMID:21895194

  3. Permutation blocking path integral Monte Carlo: a highly efficient approach to the simulation of strongly degenerate non-ideal fermions

    NASA Astrophysics Data System (ADS)

    Dornheim, Tobias; Groth, Simon; Filinov, Alexey; Bonitz, Michael

    2015-07-01

    Correlated fermions are of high interest in condensed matter (Fermi liquids, Wigner molecules), cold atomic gases and dense plasmas. Here we propose a novel approach to path integral Monte Carlo (PIMC) simulations of strongly degenerate non-ideal fermions at finite temperature by combining a fourth-order factorization of the density matrix with antisymmetric propagators, i.e., determinants, between all imaginary time slices. To efficiently run through the modified configuration space, we introduce a modification of the widely used continuous space worm algorithm, which allows for an efficient sampling at arbitrary system parameters. We demonstrate how the application of determinants achieves an effective blocking of permutations with opposite signs, leading to a significant relieve of the fermion sign problem. To benchmark the capability of our method regarding the simulation of degenerate fermions, we consider multiple electrons in a quantum dot and compare our results with other ab initio techniques, where they are available. The present permutation blocking PIMC approach allows us to obtain accurate results even for N = 20 electrons at low temperature and arbitrary coupling, where no other ab initio results have been reported, so far.

  4. Monte Carlo Simulations of Luminescent Solar Concentrators with Front-Facing Photovoltaic Cells for Building Integrated Photovoltaics

    NASA Astrophysics Data System (ADS)

    Leow, Shin; Corrado, Carley; Osborn, Melissa; Carter, Sue

    2013-03-01

    Luminescent solar concentrators (LSCs) have the ability to receive light from a wide range of angles and concentrate the captured light on to small photo active areas. This enables LSCs to be integrated more extensively into buildings as windows and wall claddings on top of roof installations. LSCs with front facing PV cells collect both direct and concentrated light ensuring a gain factor greater than one. It also allows for flexibility in determining the placement and percentage coverage of PV cells when designing panels to balance reabsorption losses, power output and the level of concentration desired. A Monte-Carlo ray tracing program was developed to study the transport of photons and loss mechanisms in LSC panels and aid in design optimization. The program imports measured absorption/emission spectra and transmission coefficients as simulation parameters. Interactions of photons with the LSC panel are determined by comparing calculated probabilities with random number generators. Simulation results reveal optimal panel dimensions and PV cell layouts to achieve maximum power output.

  5. Characterization and Monte Carlo simulation of single ion Geiger mode avalanche diodes integrated with a quantum dot nanostructure

    NASA Astrophysics Data System (ADS)

    Sharma, Peter; Abraham, J. B. S.; Ten Eyck, G.; Childs, K. D.; Bielejec, E.; Carroll, M. S.

    Detection of single ion implantation within a nanostructure is necessary for the high yield fabrication of implanted donor-based quantum computing architectures. Single ion Geiger mode avalanche (SIGMA) diodes with a laterally integrated nanostructure capable of forming a quantum dot were fabricated and characterized using photon pulses. The detection efficiency of this design was measured as a function of wavelength, lateral position, and for varying delay times between the photon pulse and the overbias detection window. Monte Carlo simulations based only on the random diffusion of photo-generated carriers and the geometrical placement of the avalanche region agrees qualitatively with device characterization. Based on these results, SIGMA detection efficiency appears to be determined solely by the diffusion of photo-generated electron-hole pairs into a buried avalanche region. Device performance is then highly dependent on the uniformity of the underlying silicon substrate and the proximity of photo-generated carriers to the silicon-silicon dioxide interface, which are the most important limiting factors for reaching the single ion detection limit with SIGMA detectors. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under Contract DE-AC04-94AL85000.

  6. Extrapolation to infinite Trotter number in path-integral Monte Carlo simulations of solid-state systems

    NASA Astrophysics Data System (ADS)

    Cuccoli, Alessandro; Macchi, Alessandro; Pedrolli, Gaia; Tognetti, Valerio; Vaia, Ruggero

    1995-05-01

    We consider the problem of the extrapolation of path-integral Monte Carlo (PIMC) data to infinite Trotter number P. Finite-P data, being even functions of P, have high-P dependence that is generally well described by a quadratic fit, a0+a1P-2, where a0 is the exact quantum value. However, in order to get convergence it is often necessary to run PIMC codes with rather high P values, which implies long computer times and larger statistical errors of the data. It is well known that also for harmonic systems the finite-P data are not exact; nevertheless, they can be easily calculated by Gaussian quadrature. Starting from this observation, we suggest an easy way to correct PIMC data for anharmonic systems in order to take into account the harmonic part exactly, with strong improvement of the extrapolation to P=∞. Lower Trotter numbers are thus required, with the advantages of computer-time saving and much better accuracy of the extrapolated values, without any change in the PIMC code. In order to demonstrate the effectiveness of the approach, we report finite-P data processing for a single anharmonic particle, whose finite-P data are obtained by the matrix-squaring method, and for a chain of atoms with Morse interaction.

  7. Is there a stable commensurate solid phase in the second 4He layer on graphite? - path integral Monte Carlo study

    NASA Astrophysics Data System (ADS)

    Ahn, Jeonghwan; Lee, Hoonkyung; Kwon, Yongkyung

    2015-03-01

    Existence of a stable commensurate structure in the second 4He layer on graphite has been a subject of intensive experimental and theoretical studies because of its implication in the possible realization of two-dimensional supersolidity. Earlier path-integral Monte Carlo (PIMC) calculations of Pierce and Manousakis predicted a stable C4/7 commensurate structure above the first-layer 4He atoms fixed at triangular lattice sites, but Corboz et al. later showed that no commensurate phase was stable when quantum dynamics of the first-layer 4He atoms was incorporated in the PIMC calculations. On the other hand, recent heat capacity measurements of Nakamura et al. provided a strong evidence for a commensurate solid in the second 4He layer over an extended density range. Motivated by this, we have performed new PIMC calculations for the second helium layer on graphite. Unlike previous PIMC calculations where a laterally-averaged one-dimensional substrate potential was used, we here employ an anisotropic 4He-graphite potential described by a sum of the 4He-C pair potentials. With this fully-corrugated substrate potential we make more accurate description of quantum dynamics of the first-layer 4He atoms and analyze its effects on the phase diagram of the second layer.

  8. Sensing and actuating capabilities of a shape memory polymer composite integrated with hybrid filler

    NASA Astrophysics Data System (ADS)

    Lu, Haibao; Yu, Kai; Liu, Yanju; Leng, Jinsong

    2010-06-01

    In this paper, hybrid fillers, including carbon black (CB) and chopped short carbon fibers (SCF), are integrated into a styrene-based shape memory polymer (SMP) with sensing and actuating capabilities. The hybrid filler is expected to transform insulating SMP into conducting. Static mechanical properties of the SMP composites containing various filler concentrations of hybrid filler reinforcement are studied first, and it is theoretically and experimentally confirmed that the mechanical properties are significantly improved by a factor of filler content of SCF. The excellent electrical properties of this novel type of SMP composite are determined by a four-point-probe method. As a consequence, the sensing properties of SMP composite filled with 5 wt% CB and 2 wt% SCF are characterized by functions of temperature and strain. These two experimental results both aid the use of SMP composites as sensors that respond to changes in temperature or mechanical loads. On the other hand, the actuating capability of SMP composites is also validated and demonstrated. The dynamic mechanical analysis result reveals that the output strength of SMP composites is improved with an increase in filler content of SCF. The actuating capability of SMP composites is subsequently demonstrated in a series of photographs.

  9. Using a hybrid Monte Carlo/Genetic Algorithm Slip Estimator to produce high resolution models of paleoearthquakes from geodetic data

    NASA Astrophysics Data System (ADS)

    Lindsay, A.; McCloskey, J.; Nalbant, S. S.; Simao, N.; Murphy, S.; NicBhloscaidh, M.; Steacy, S.

    2013-12-01

    Identifying fault sections where slip deficits have accumulated may provide a means for understanding sequences of large megathrust earthquakes. Stress accumulated during the interseismic period on locked sections of an active fault is stored as potential slip. Where this potential slip remains unreleased during earthquakes, a slip deficit can be said to have accrued. Analysis of the spatial distribution of slip during antecedent events along the fault will show where the locked plate has spent its stored slip and indicate where the potential for large events remains. The location of recent earthquakes and their distribution of slip can be estimated instrumentally. To develop the idea of long-term slip-deficit modelling it is necessary to constrain the size and distribution of slip for pre-instrumental events dating back hundreds of years covering more than one ';seismic cycle'. This requires the exploitation of proxy sources of data. Coral microatolls, growing in the intertidal zone of the outer island arc of the Sunda trench, present the possibility of producing high resolution reconstructions of slip for a number of pre-instrumental earthquakes. Their growth is influenced by tectonic flexing of the continental plate beneath them allows them to act as long term geodetic recorders. However, the sparse distribution of data available using coral geodesy results in a under determined problem with non-unique solutions. Instead of producing one definite model satisfying the observed corals displacements, a Monte Carlo Slip Estimator based on a Genetic Algorithm (MCSE-GA) accelerating the rate of convergence is used to identify a suite of models consistent with the data. Successive iterations of the MCSE-GA sample different displacements at each coral location, from within the spread of associated uncertainties, producing a catalog of models from the full range of possibilities. The suite of best slip distributions are weighted according to their fitness and stacked to produce a final estimate of the distribution of slip for a particular earthquake. Examination of the slip values in the stacked models allows areas of high confidence to be identified where the standard deviation is low. Similarly, areas of low confidence will be found where standard deviations are high. These high resolution models can be used to reconstruct a history of slip along the fault, both identifying and quantifying of slip deficits and constraining confidence in the accuracy of the modelled information. This presentation will demonstrate the ability of the MCSE-GA to produce accurate models of slip for instrumentally recorded earthquakes and show estimates for slip during paleoearthquakes along the Sunda Megathrust.

  10. Solution of the Nonlinear Mixed Volterra-Fredholm Integral Equations by Hybrid of Block-Pulse Functions and Bernoulli Polynomials

    PubMed Central

    Mashayekhi, S.; Razzaghi, M.; Tripak, O.

    2014-01-01

    A new numerical method for solving the nonlinear mixed Volterra-Fredholm integral equations is presented. This method is based upon hybrid functions approximation. The properties of hybrid functions consisting of block-pulse functions and Bernoulli polynomials are presented. The operational matrices of integration and product are given. These matrices are then utilized to reduce the nonlinear mixed Volterra-Fredholm integral equations to the solution of algebraic equations. Illustrative examples are included to demonstrate the validity and applicability of the technique. PMID:24523638

  11. Validation of columnar CsI x-ray detector responses obtained with hybridMANTIS, a CPU-GPU Monte Carlo code for coupled x-ray, electron, and optical transport

    SciTech Connect

    Sharma, Diksha; Badano, Aldo

    2013-03-15

    Purpose: hybridMANTIS is a Monte Carlo package for modeling indirect x-ray imagers using columnar geometry based on a hybrid concept that maximizes the utilization of available CPU and graphics processing unit processors in a workstation. Methods: The authors compare hybridMANTIS x-ray response simulations to previously published MANTIS and experimental data for four cesium iodide scintillator screens. These screens have a variety of reflective and absorptive surfaces with different thicknesses. The authors analyze hybridMANTIS results in terms of modulation transfer function and calculate the root mean square difference and Swank factors from simulated and experimental results. Results: The comparison suggests that hybridMANTIS better matches the experimental data as compared to MANTIS, especially at high spatial frequencies and for the thicker screens. hybridMANTIS simulations are much faster than MANTIS with speed-ups up to 5260. Conclusions: hybridMANTIS is a useful tool for improved description and optimization of image acquisition stages in medical imaging systems and for modeling the forward problem in iterative reconstruction algorithms.

  12. Towards integration of PET/MR hybrid imaging into radiation therapy treatment planning

    SciTech Connect

    Paulus, Daniel H.; Thorwath, Daniela; Schmidt, Holger; Quick, Harald H.

    2014-07-15

    Purpose: Multimodality imaging has become an important adjunct of state-of-the-art radiation therapy (RT) treatment planning. Recently, simultaneous PET/MR hybrid imaging has become clinically available and may also contribute to target volume delineation and biological individualization in RT planning. For integration of PET/MR hybrid imaging into RT treatment planning, compatible dedicated RT devices are required for accurate patient positioning. In this study, prototype RT positioning devices intended for PET/MR hybrid imaging are introduced and tested toward PET/MR compatibility and image quality. Methods: A prototype flat RT table overlay and two radiofrequency (RF) coil holders that each fix one flexible body matrix RF coil for RT head/neck imaging have been evaluated within this study. MR image quality with the RT head setup was compared to the actual PET/MR setup with a dedicated head RF coil. PET photon attenuation and CT-based attenuation correction (AC) of the hardware components has been quantitatively evaluated by phantom scans. Clinical application of the new RT setup in PET/MR imaging was evaluated in anin vivo study. Results: The RT table overlay and RF coil holders are fully PET/MR compatible. MR phantom and volunteer imaging with the RT head setup revealed high image quality, comparable to images acquired with the dedicated PET/MR head RF coil, albeit with 25% reduced SNR. Repositioning accuracy of the RF coil holders was below 1 mm. PET photon attenuation of the RT table overlay was calculated to be 3.8% and 13.8% for the RF coil holders. With CT-based AC of the devices, the underestimation error was reduced to 0.6% and 0.8%, respectively. Comparable results were found within the patient study. Conclusions: The newly designed RT devices for hybrid PET/MR imaging are PET and MR compatible. The mechanically rigid design and the reproducible positioning allow for straightforward CT-based AC. The systematic evaluation within this study provides the technical basis for the clinical integration of PET/MR hybrid imaging into RT treatment planning.

  13. A Massively Parallel Hybrid Dusty-Gasdynamics and Kinetic Direct Simulation Monte Carlo Model for Planetary Applications

    NASA Technical Reports Server (NTRS)

    Combi, Michael R.

    2004-01-01

    In order to understand the global structure, dynamics, and physical and chemical processes occurring in the upper atmospheres, exospheres, and ionospheres of the Earth, the other planets, comets and planetary satellites and their interactions with their outer particles and fields environs, it is often necessary to address the fundamentally non-equilibrium aspects of the physical environment. These are regions where complex chemistry, energetics, and electromagnetic field influences are important. Traditional approaches are based largely on hydrodynamic or magnetohydrodynamic (MHD) formulations and are very important and highly useful. However, these methods often have limitations in rarefied physical regimes where the molecular collision rates and ion gyrofrequencies are small and where interactions with ionospheres and upper neutral atmospheres are important. At the University of Michigan we have an established base of experience and expertise in numerical simulations based on particle codes which address these physical regimes. The Principal Investigator, Dr. Michael Combi, has over 20 years of experience in the development of particle-kinetic and hybrid kinetichydrodynamics models and their direct use in data analysis. He has also worked in ground-based and space-based remote observational work and on spacecraft instrument teams. His research has involved studies of cometary atmospheres and ionospheres and their interaction with the solar wind, the neutral gas clouds escaping from Jupiter s moon Io, the interaction of the atmospheres/ionospheres of Io and Europa with Jupiter s corotating magnetosphere, as well as Earth s ionosphere. This report describes our progress during the year. The contained in section 2 of this report will serve as the basis of a paper describing the method and its application to the cometary coma that will be continued under a research and analysis grant that supports various applications of theoretical comet models to understanding the inner comae of comets (grant NAGS- 13239 from the Planetary Atmospheres program).

  14. Hybrid extended particle filter (HEPF) for integrated inertial navigation and global positioning systems

    NASA Astrophysics Data System (ADS)

    Aggarwal, Priyanka; Syed, Zainab; El-Sheimy, Naser

    2009-05-01

    Navigation includes the integration of methodologies and systems for estimating time-varying position, velocity and attitude of moving objects. Navigation incorporating the integrated inertial navigation system (INS) and global positioning system (GPS) generally requires extensive evaluations of nonlinear equations involving double integration. Currently, integrated navigation systems are commonly implemented using the extended Kalman filter (EKF). The EKF assumes a linearized process, measurement models and Gaussian noise distributions. These assumptions are unrealistic for highly nonlinear systems like land vehicle navigation and may cause filter divergence. A particle filter (PF) is developed to enhance integrated INS/GPS system performance as it can easily deal with nonlinearity and non-Gaussian noises. In this paper, a hybrid extended particle filter (HEPF) is developed as an alternative to the well-known EKF to achieve better navigation data accuracy for low-cost microelectromechanical system sensors. The results show that the HEPF performs better than the EKF during GPS outages, especially when simulated outages are located in periods with high vehicle dynamics.

  15. The ObjECTS: Framework for Integrated Assessment: Hybrid Modeling of Transportation

    SciTech Connect

    Kim, Son H.; Edmonds, James A.; Lurz, Joshua; Smith, Steven J.; Wise, Marshall A.

    2006-09-01

    Technology is a central issue for the global climate change problem, requiring analysis tools that can examine the impact of specific technologies with a long-term, global context. This paper describes the architecture of the ObjECTS-MiniCAM integrated assessment model, which implements a long-term, global model of energy, economy, agriculture, land-use, atmosphere, and climate change in a framework that allows the flexible incorporation of explicit technology detail. We describe the implementation of a ''bottom-up'' representation of the transportation sector as an illustration of this approach, in which the resulting hybrid model is fully integrated, internally consistent and theoretically compatible with the regional and global modeling framework. The analysis of the transportation sector presented here supports and clarifies the need for a comprehensive strategy promoting advanced vehicle technologies and an economy-wide carbon policy to cost-effectively reduce carbon emissions from the transportation sector in the long-term.

  16. Integration of plug-in hybrid electric vehicles (PHEV) with grid connected residential photovoltaic energy systems

    NASA Astrophysics Data System (ADS)

    Nagarajan, Adarsh; Shireen, Wajiha

    2013-06-01

    This paper proposes an approach for integrating Plug-In Hybrid Electric Vehicles (PHEV) to an existing residential photovoltaic system, to control and optimize the power consumption of residential load. Control involves determining the source from which residential load will be catered, where as optimization of power flow reduces the stress on the grid. The system built to achieve the goal is a combination of the existing residential photovoltaic system, PHEV, Power Conditioning Unit (PCU), and a controller. The PCU involves two DC-DC Boost Converters and an inverter. This paper emphasizes on developing the controller logic and its implementation in order to accommodate the flexibility and benefits of the proposed integrated system. The proposed controller logic has been simulated using MATLAB SIMULINK and further implemented using Digital Signal Processor (DSP) microcontroller, TMS320F28035, from Texas Instruments

  17. Integration Issues of Cells into Battery Packs for Plug-in and Hybrid Electric Vehicles: Preprint

    SciTech Connect

    Pesaran, A. A.; Kim, G. H.; Keyser, M.

    2009-05-01

    The main barriers to increased market share of hybrid electric vehicles (HEVs) and commercialization of plug-in HEVs are the cost, safety, and life of lithium ion batteries. Significant effort is being directed to address these issues for lithium ion cells. However, even the best cells may not perform as well when integrated into packs for vehicles because of the environment in which vehicles operate. This paper discusses mechanical, electrical, and thermal integration issues and vehicle interface issues that could impact the cost, life, and safety of the system. It also compares the advantages and disadvantages of using many small cells versus a few large cells and using prismatic cells versus cylindrical cells.

  18. Integrating Hybrid Life Cycle Assessment with Multiobjective Optimization: A Modeling Framework.

    PubMed

    Yue, Dajun; Pandya, Shyama; You, Fengqi

    2016-02-01

    By combining life cycle assessment (LCA) with multiobjective optimization (MOO), the life cycle optimization (LCO) framework holds the promise not only to evaluate the environmental impacts for a given product but also to compare different alternatives and identify both ecologically and economically better decisions. Despite the recent methodological developments in LCA, most LCO applications are developed upon process-based LCA, which results in system boundary truncation and underestimation of the true impact. In this study, we propose a comprehensive LCO framework that seamlessly integrates MOO with integrated hybrid LCA. It quantifies both direct and indirect environmental impacts and incorporates them into the decision making process in addition to the more traditional economic criteria. The proposed LCO framework is demonstrated through an application on sustainable design of a potential bioethanol supply chain in the UK. Results indicate that the proposed hybrid LCO framework identifies a considerable amount of indirect greenhouse gas emissions (up to 58.4%) that are essentially ignored in process-based LCO. Among the biomass feedstock options considered, using woody biomass for bioethanol production would be the most preferable choice from a climate perspective, while the mixed use of wheat and wheat straw as feedstocks would be the most cost-effective one. PMID:26752618

  19. Fully integrated hybrid silicon free-space beam steering source with 32-channel phased array

    NASA Astrophysics Data System (ADS)

    Hulme, J. C.; Doylend, J. K.; Heck, M. J. R.; Peters, J. D.; Davenport, M. L.; Bovington, J. T.; Coldren, L. A.; Bowers, J. E.

    2014-03-01

    Free-space beam steering using optical phased arrays is a promising method for implementing free-space communication links and Light Detection and Ranging (LIDAR) without the sensitivity to inertial forces and long latencies which characterize moving parts. Implementing this approach on a silicon-based photonic integrated circuit adds the additional advantage of working with highly developed CMOS processing techniques. In this work we discuss our progress in the development of a fully integrated 32 channel PIC with a widely tunable diode laser, a waveguide phased array, an array of fast phase modulators, an array of hybrid III-V/silicon amplifiers, surface gratings, and a graded index lens (GRIN) feeding an array of photodiodes for feedback control. The PIC has been designed to provide beam steering across a 15°x5° field of view with 0.6°x0.6° beam width and background peaks suppressed 15 dB relative to the main lobe within the field of view for arbitrarily chosen beam directions. Fabrication follows the hybrid silicon process developed at UCSB with modifications to incorporate silicon diodes and a GRIN lens.

  20. Hybrid integrated biological-solid-state system powered with adenosine triphosphate

    NASA Astrophysics Data System (ADS)

    Roseman, Jared M.; Lin, Jianxun; Ramakrishnan, Siddharth; Rosenstein, Jacob K.; Shepard, Kenneth L.

    2015-12-01

    There is enormous potential in combining the capabilities of the biological and the solid state to create hybrid engineered systems. While there have been recent efforts to harness power from naturally occurring potentials in living systems in plants and animals to power complementary metal-oxide-semiconductor integrated circuits, here we report the first successful effort to isolate the energetics of an electrogenic ion pump in an engineered in vitro environment to power such an artificial system. An integrated circuit is powered by adenosine triphosphate through the action of Na+/K+ adenosine triphosphatases in an integrated in vitro lipid bilayer membrane. The ion pumps (active in the membrane at numbers exceeding 2 × 106 mm-2) are able to sustain a short-circuit current of 32.6 pA mm-2 and an open-circuit voltage of 78 mV, providing for a maximum power transfer of 1.27 pW mm-2 from a single bilayer. Two series-stacked bilayers provide a voltage sufficient to operate an integrated circuit with a conversion efficiency of chemical to electrical energy of 14.9%.

  1. Hybrid integrated biological–solid-state system powered with adenosine triphosphate

    PubMed Central

    Roseman, Jared M.; Lin, Jianxun; Ramakrishnan, Siddharth; Rosenstein, Jacob K.; Shepard, Kenneth L.

    2015-01-01

    There is enormous potential in combining the capabilities of the biological and the solid state to create hybrid engineered systems. While there have been recent efforts to harness power from naturally occurring potentials in living systems in plants and animals to power complementary metal-oxide-semiconductor integrated circuits, here we report the first successful effort to isolate the energetics of an electrogenic ion pump in an engineered in vitro environment to power such an artificial system. An integrated circuit is powered by adenosine triphosphate through the action of Na+/K+ adenosine triphosphatases in an integrated in vitro lipid bilayer membrane. The ion pumps (active in the membrane at numbers exceeding 2 × 106 mm−2) are able to sustain a short-circuit current of 32.6 pA mm−2 and an open-circuit voltage of 78 mV, providing for a maximum power transfer of 1.27 pW mm−2 from a single bilayer. Two series-stacked bilayers provide a voltage sufficient to operate an integrated circuit with a conversion efficiency of chemical to electrical energy of 14.9%. PMID:26638983

  2. Hybrid integrated biological-solid-state system powered with adenosine triphosphate.

    PubMed

    Roseman, Jared M; Lin, Jianxun; Ramakrishnan, Siddharth; Rosenstein, Jacob K; Shepard, Kenneth L

    2015-01-01

    There is enormous potential in combining the capabilities of the biological and the solid state to create hybrid engineered systems. While there have been recent efforts to harness power from naturally occurring potentials in living systems in plants and animals to power complementary metal-oxide-semiconductor integrated circuits, here we report the first successful effort to isolate the energetics of an electrogenic ion pump in an engineered in vitro environment to power such an artificial system. An integrated circuit is powered by adenosine triphosphate through the action of Na(+)/K(+) adenosine triphosphatases in an integrated in vitro lipid bilayer membrane. The ion pumps (active in the membrane at numbers exceeding 2 × 10(6) mm(-2)) are able to sustain a short-circuit current of 32.6 pA mm(-2) and an open-circuit voltage of 78 mV, providing for a maximum power transfer of 1.27 pW mm(-2) from a single bilayer. Two series-stacked bilayers provide a voltage sufficient to operate an integrated circuit with a conversion efficiency of chemical to electrical energy of 14.9%. PMID:26638983

  3. Path integral Monte Carlo simulations of H2 adsorbed to lithium-doped benzene: A model for hydrogen storage materials.

    PubMed

    Lindoy, Lachlan P; Kolmann, Stephen J; D'Arcy, Jordan H; Crittenden, Deborah L; Jordan, Meredith J T

    2015-11-21

    Finite temperature quantum and anharmonic effects are studied in H2-Li(+)-benzene, a model hydrogen storage material, using path integral Monte Carlo (PIMC) simulations on an interpolated potential energy surface refined over the eight intermolecular degrees of freedom based upon M05-2X/6-311+G(2df,p) density functional theory calculations. Rigid-body PIMC simulations are performed at temperatures ranging from 77 K to 150 K, producing both quantum and classical probability density histograms describing the adsorbed H2. Quantum effects broaden the histograms with respect to their classical analogues and increase the expectation values of the radial and angular polar coordinates describing the location of the center-of-mass of the H2 molecule. The rigid-body PIMC simulations also provide estimates of the change in internal energy, ΔUads, and enthalpy, ΔHads, for H2 adsorption onto Li(+)-benzene, as a function of temperature. These estimates indicate that quantum effects are important even at room temperature and classical results should be interpreted with caution. Our results also show that anharmonicity is more important in the calculation of U and H than coupling-coupling between the intermolecular degrees of freedom becomes less important as temperature increases whereas anharmonicity becomes more important. The most anharmonic motions in H2-Li(+)-benzene are the "helicopter" and "ferris wheel" H2 rotations. Treating these motions as one-dimensional free and hindered rotors, respectively, provides simple corrections to standard harmonic oscillator, rigid rotor thermochemical expressions for internal energy and enthalpy that encapsulate the majority of the anharmonicity. At 150 K, our best rigid-body PIMC estimates for ΔUads and ΔHads are -13.3 ± 0.1 and -14.5 ± 0.1 kJ mol(-1), respectively. PMID:26590532

  4. Path integral Monte Carlo simulations of H2 adsorbed to lithium-doped benzene: A model for hydrogen storage materials

    NASA Astrophysics Data System (ADS)

    Lindoy, Lachlan P.; Kolmann, Stephen J.; D'Arcy, Jordan H.; Crittenden, Deborah L.; Jordan, Meredith J. T.

    2015-11-01

    Finite temperature quantum and anharmonic effects are studied in H2-Li+-benzene, a model hydrogen storage material, using path integral Monte Carlo (PIMC) simulations on an interpolated potential energy surface refined over the eight intermolecular degrees of freedom based upon M05-2X/6-311+G(2df,p) density functional theory calculations. Rigid-body PIMC simulations are performed at temperatures ranging from 77 K to 150 K, producing both quantum and classical probability density histograms describing the adsorbed H2. Quantum effects broaden the histograms with respect to their classical analogues and increase the expectation values of the radial and angular polar coordinates describing the location of the center-of-mass of the H2 molecule. The rigid-body PIMC simulations also provide estimates of the change in internal energy, ΔUads, and enthalpy, ΔHads, for H2 adsorption onto Li+-benzene, as a function of temperature. These estimates indicate that quantum effects are important even at room temperature and classical results should be interpreted with caution. Our results also show that anharmonicity is more important in the calculation of U and H than coupling—coupling between the intermolecular degrees of freedom becomes less important as temperature increases whereas anharmonicity becomes more important. The most anharmonic motions in H2-Li+-benzene are the "helicopter" and "ferris wheel" H2 rotations. Treating these motions as one-dimensional free and hindered rotors, respectively, provides simple corrections to standard harmonic oscillator, rigid rotor thermochemical expressions for internal energy and enthalpy that encapsulate the majority of the anharmonicity. At 150 K, our best rigid-body PIMC estimates for ΔUads and ΔHads are -13.3 ± 0.1 and -14.5 ± 0.1 kJ mol-1, respectively.

  5. Hybrid integration of synthesized dielectric image waveguides in substrate integrated circuit technology and its millimeter wave applications

    NASA Astrophysics Data System (ADS)

    Patrovsky, Andreas

    This thesis deals with a novel type of integrated dielectric waveguide which is synthesized on a planar grounded substrate by perforation of the zones adjacent to a guiding channel in the center. The resulting Substrate Integrated Image Guide (SIIG) not only allows for low-loss guidance of electromagnetic waves in a similar way as the standard image guide, but also meets the requirements of low cost and ease of integration. A first objective was the detailed analysis of the propagation properties of fundamental and higher order modes in this waveguide structure, regarding attenuation, dispersion behavior, bandwidth, leakage effects, and the impact of fabrication tolerances. For this purpose, specifically adapted techniques of analysis are presented, since established methods for the conventional image guide can not be applied to the more complex periodic SIIG. Commercial electromagnetic full-wave software is used along with a dual-line approach involving a subsequent extraction of the propagation constant from simulated S-parameters. Alternatively, the solution of the eigenmode problem of a single SIIG unit cell also performs the task. Both techniques are in good agreement and provide accurate results, which is supported by measurements on laser-fabricated prototypes. It is shown that the achievable attenuation is much lower than in the standard integrated technologies and that losses mainly depend on the chosen dielectric material. As a consequence, the SIIG also is an attractive technology for applications beyond the mmW band, i. e. in the terahertz range. Design recommendations for the geometric parameters of the SIIG are discussed and a simplified equivalent model with homogeneous dielectric regions is introduced to speed up the design of passive components. Low-loss transitions between dissimilar waveguide structures are indispensable key components for a hybrid integrated platform. In order to enable the connection of standard measurement equipment in the W-band (75 GHz to 110 GHz), a transition from rectangular waveguide to SIIG was developed. Another transition to either microstrip or CPW is essential to enable coplanar probe measurements and to achieve compatibility with monolithic millimeter wave integrated circuits (MMICs). Microstrip and image guide have very different requirements for the substrate thickness, for which reason efforts were concentrated on a wideband transition between the SIIG and CPW. The designed transition shows good broadband performance and minimal radiation loss. Other transitions from the SIIG to the Substrate Integrated Waveguide (SIW) are also presented in the context of substrate integrated circuits (SICs). The latter technology combines planar transmission lines and originally non-planar waveguide structures that are synthesized in planar form on a common substrate. High alignment precision is a direct consequence, which eliminates the necessity for additional tuning. As an open dielectric waveguide technology with very small transmission loss, the SIIG is particularly suitable for antennas and corresponding feed lines. The similarity of the SIIG with other dielectric waveguides and especially with the image guide suggests a knowledge transfer from known dielectric antennas. A planar SIIG rod antenna was designed and fabricated, as a derivative of the established polyrod antenna. The structural shape is simple and compact, and it provides a medium gain in the range of 10 dBi to 15 dBi. A second developed type, an SIIG traveling-wave linear array antenna, is frequency-steerable through broadside due to special radiation elements. The novel design of a slab-mode antenna forms an endfire beam by a planar lens configuration. In addition, all of those dielectric-based antennas are highly efficient. Being synthesized on a planar substrate, the SIIG can be combined in a hybrid way with other waveguide structures on the same substrate in so-called substrate integrated circuits (SICs). It joins the SIW and the Substrate Integrated Non-Radiative Dielectric guide (SINRD) and adds unique features like even lower loss and more tolerant, eased fabrication, since only non-metallized air holes are needed. In this context, the SIW is modified for fabrication on electrically thick substrates to achieve compatibility with the SIIG at exceedingly high frequencies. Based on a novel topology, hybrid SIW-CPW forward couplers were designed and the provided theory accurately predicts the coupling behavior. Finally, an SIIG antenna was integrated together with an MMIC low-noise amplifier at 60 GHz to prove the concept of active SICs. (Abstract shortened by UMI.)

  6. Analysis of dpa Rates in the HFIR Reactor Vessel using a Hybrid Monte Carlo/Deterministic Method

    NASA Astrophysics Data System (ADS)

    Risner, J. M.; Blakeman, E. D.

    2016-02-01

    The Oak Ridge High Flux Isotope Reactor (HFIR), which began full-power operation in 1966, provides one of the highest steady-state neutron flux levels of any research reactor in the world. An ongoing vessel integrity analysis program to assess radiation-induced embrittlement of the HFIR reactor vessel requires the calculation of neutron and gamma displacements per atom (dpa), particularly at locations near the beam tube nozzles, where radiation streaming effects are most pronounced. In this study we apply the Forward-Weighted Consistent Adjoint Driven Importance Sampling (FW-CADIS) technique in the ADVANTG code to develop variance reduction parameters for use in the MCNP radiation transport code. We initially evaluated dpa rates for dosimetry capsule locations, regions in the vicinity of the HB-2 beamline, and the vessel beltline region. We then extended the study to provide dpa rate maps using three-dimensional cylindrical mesh tallies that extend from approximately 12 in. below to approximately 12 in. above the height of the core. The mesh tally structures contain over 15,000 mesh cells, providing a detailed spatial map of neutron and photon dpa rates at all locations of interest. Relative errors in the mesh tally cells are typically less than 1%. Notice: This manuscript has been authored by UT-Battelle, LLC, under Contract No. DE-AC0500OR22725 with the US Department of Energy. The US Government retains and the publisher, by accepting the article for publication, acknowledges that the US Government retains a nonexclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for the US Government purposes.

  7. Transcap: A new integrated hybrid supercapacitor and electrolyte-gated transistor device (Presentation Recording)

    NASA Astrophysics Data System (ADS)

    Santato, Clara

    2015-10-01

    The boom in multifunctional, flexible, and portable electronics and the increasing need of low-energy cost and autonomy for applications ranging from wireless sensor networks for smart environments to biomedical applications are triggering research efforts towards the development of self-powered sustainable electronic devices. Within this context, the coupling of electronic devices (e.g. sensors, transistors) with small size energy storage systems (e.g. micro-batteries or micro-supercapacitors) is actively pursued. Micro-electrochemical supercapacitors are attracting much attention in electronics for their capability of delivering short power pulses with high stability over repeated charge/discharge cycling. For their high specific pseudocapacitance, electronically conducting polymers are well known as positive materials for hybrid supercapacitors featuring high surface carbon negative electrodes. The processability of both polymer and carbon is of great relevance for the development of flexible miniaturised devices. Electronically conducting polymers are even well known to feature an electronic conductivity that depends on their oxidation (p-doped state) and that it is modulated by the polymer potential. This property and the related pseudocapacitive response make polymer very attracting channel materials for electrolyte-gated (EG) transistors. Here, we propose a novel concept of "Trans-capacitor", an integrated device that exhibits the storage properties of a polymer/carbon hybrid supercapacitor and the low-voltage operation of an electrolyte-gated transistor.

  8. Automatic on-chip RNA-DNA hybridization assay with integrated phase change microvalves

    NASA Astrophysics Data System (ADS)

    Weng, Xuan; Jiang, Hai; Wang, Junsheng; Chen, Shu; Cao, Honghe; Li, Dongqing

    2012-07-01

    An RNA-DNA hybridization assay microfluidic chip integrated with electrothermally actuated phase change microvalves for detecting pathogenic bacteria is presented in this paper. In order to realize the sequential loading and washing processes required in such an assay, gravity-based pressure-driven flow and phase-change microvalves were used in the microfluidic chip. Paraffin wax was used as the phase change material in the valves and thin film heaters were used to electrothermally actuate microvalves. Light absorption measured by a photodetector to determine the concentrations of the samples. The automatic control of the complete assay was implemented by a self-coded LabVIEW program. To examine the performance of this chip, Salmonella was used as a sample pathogen. Significantly, reduction in reagent/sample consumption (up to 20 folds) was achieved by this on-chip assay, compared with using the commercial test kit following the same protocol in conventional labs. The experimental results show that the quantitative detection can be obtained in approximately 26 min, and the detection limit is as low as 103 CFU ml-1. This RNA-DNA hybridization assay microfluidic chip shows an excellent potential in the development of a portable device for point-of-testing applications.

  9. Hybrid surgical guidance based on the integration of radionuclear and optical technologies.

    PubMed

    van Leeuwen, Fijs W B; Valdés-Olmos, Renato; Buckle, Tessa; Vidal-Sicart, Sergi

    2016-06-01

    With the evolution of imaging technologies and tracers, the applications for nuclear molecular imaging are growing rapidly. For example, nuclear medicine is increasingly being used to guide surgical resections in complex anatomical locations. Here, a future workflow is envisioned that uses a combination of pre-operative diagnostics, navigation and intraoperative guidance. Radioguidance can provide means for pre-operative and intraoperative identification of "hot" lesions, forming the basis of a virtual data set that can be used for navigation. Luminescence guidance has shown great potential in the intraoperative setting by providing optical feedback, in some cases even in real time. Both of these techniques have distinct drawbacks, which include inaccuracy in areas that contain a background signal (radioactivity) or a limited degree of signal penetration (luminescence). We, and others, have reasoned that hybrid/multimodal approaches that integrate the use of these complementary modalities may help overcome their individual weaknesses. Ultimately, this will lead to advancement of the field of interventional molecular imaging/image-guided surgery. In this review, an overview of clinically applied hybrid surgical guidance technologies is given, whereby the focus is placed on tracers and hardware. PMID:26943463

  10. Large arrays of spatial light modulators hybridized to silicon integrated circuits.

    PubMed

    Worchesky, T L; Ritter, K J; Martin, R; Lane, B

    1996-03-10

    Large, high-frame-rate spatial light modulators are key components required for the realization of real-time optical processors. We report a 128 × 128 array of GaAs-based optical modulators that we hybridized to a Si integrated circuit by using In bump bonds to form a spatial light modulator. These optical modulators are composed of a series of quantum wells within an asymmetric Fabry-Perot cavity to control the optical properties. The resulting 128 × 128 element array operates in an intensity-only reflection mode at greater than 100,000 frames per second. This array interfaces to a 486-based personal computer through a standard industry standard architecture bus. PMID:21085230

  11. Electrocoagulation-integrated hybrid membrane processes for the treatment of tannery wastewater.

    PubMed

    Keerthi; Vinduja, V; Balasubramanian, N

    2013-10-01

    Three different combinations of treatment techniques, i.e. electrocoagulation combined with microfiltration (EMR), membrane bioreactor (MBR) and electrocoagulation integrated with membrane bioreactor (hybrid MBR, (HMBR)), were analysed and compared for the treatment of tannery wastewater operated for 7 days under the constant trans-membrane pressure of 5 kPa. HMBR was found to be most suitable in performance as well as fouling reduction, with 94 % of chemical oxygen demand (COD) removal, 100 % chromium removal and 8 % improvement in percentage reduction in permeate flux compared to MBR with only 90 % COD removal and 67 % chromium removal. The effect of mixed liquor suspended solids on fouling was also investigated and was found to be insignificant. EMR was capable of elevating the flux but was not as efficient as HMBR and MBR in COD removal. Fouling reduction by HMBR was further confirmed by SEM-EDX and particle size analysis. PMID:23653316

  12. A hybrid design methodology for structuring an Integrated Environmental Management System (IEMS) for shipping business.

    PubMed

    Celik, Metin

    2009-03-01

    The International Safety Management (ISM) Code defines a broad framework for the safe management and operation of merchant ships, maintaining high standards of safety and environmental protection. On the other hand, ISO 14001:2004 provides a generic, worldwide environmental management standard that has been utilized by several industries. Both the ISM Code and ISO 14001:2004 have the practical goal of establishing a sustainable Integrated Environmental Management System (IEMS) for shipping businesses. This paper presents a hybrid design methodology that shows how requirements from both standards can be combined into a single execution scheme. Specifically, the Analytic Hierarchy Process (AHP) and Fuzzy Axiomatic Design (FAD) are used to structure an IEMS for ship management companies. This research provides decision aid to maritime executives in order to enhance the environmental performance in the shipping industry. PMID:19038488

  13. MC21 v.6.0 - A Continuous-Energy Monte Carlo Particle Transport Code with Integrated Reactor Feedback Capabilities

    NASA Astrophysics Data System (ADS)

    Griesheimer, D. P.; Gill, D. F.; Nease, B. R.; Sutton, T. M.; Stedry, M. H.; Dobreff, P. S.; Carpenter, D. C.; Trumbull, T. H.; Caro, E.; Joo, H.; Millman, D. L.

    2014-06-01

    MC21 is a continuous-energy Monte Carlo radiation transport code for the calculation of the steady-state spatial distributions of reaction rates in three-dimensional models. The code supports neutron and photon transport in fixed source problems, as well as iterated-fission-source (eigenvalue) neutron transport problems. MC21 has been designed and optimized to support large-scale problems in reactor physics, shielding, and criticality analysis applications. The code also supports many in-line reactor feedback effects, including depletion, thermal feedback, xenon feedback, eigenvalue search, and neutron and photon heating. MC21 uses continuous-energy neutron/nucleus interaction physics over the range from 10-5 eV to 20 MeV. The code treats all common neutron scattering mechanisms, including fast-range elastic and non-elastic scattering, and thermal- and epithermal-range scattering from molecules and crystalline materials. For photon transport, MC21 uses continuous-energy interaction physics over the energy range from 1 keV to 100 GeV. The code treats all common photon interaction mechanisms, including Compton scattering, pair production, and photoelectric interactions. All of the nuclear data required by MC21 is provided by the NDEX system of codes, which extracts and processes data from EPDL-, ENDF-, and ACE-formatted source files. For geometry representation, MC21 employs a flexible constructive solid geometry system that allows users to create spatial cells from first- and second-order surfaces. The system also allows models to be built up as hierarchical collections of previously defined spatial cells, with interior detail provided by grids and template overlays. Results are collected by a generalized tally capability which allows users to edit integral flux and reaction rate information. Results can be collected over the entire problem or within specific regions of interest through the use of phase filters that control which particles are allowed to score each tally. The tally system has been optimized to maintain a high level of efficiency, even as the number of edit regions becomes very large.

  14. How safe is control banding? Integrated evaluation by comparing OELs with measurement data and using monte carlo simulation.

    PubMed

    Tischer, Martin; Bredendiek-Kmper, Susanne; Poppek, Ulrich; Packroff, Rolf

    2009-07-01

    The present study aims to explore the protection level that can be achieved by the German control banding (CB) tool Einfaches Massnahmenkonzept Gefahrstoffe, 'Easy-to-use workplace control scheme for hazardous substances'. The rationale of our integrated approach is based on the Bewertungsindex (BWI), which is the quotient of the exposure level and the occupational exposure limit (OEL), with BWI <1 indicating compliance. The frequency distributions of the BWI were calculated in order to reflect statistically the variability of workplace conditions. The corresponding statistical values of the frequency distributions (percentiles etc.) are interpreted as an indicator of the level of protection that is achieved. The occupational exposure data sets used in the calculation of the BWI frequency distribution were mainly collected from Bundesanstalt fr Arbeitsschutz und Arbeitsmedizin field studies. The data sets taken into account were selected according to the criteria 'hazard band, exposure potential, control approach'. Such a combination is called the 'control banding scenario' (CBS). Measurement data are only available for two CBS: in the case of the CBS 'hazard band A, EPL3, CS1' the only data that are available (n = 220) relate to propane-2-ol as used in the area of offset printing. Only 0.4 % of the BWI are above 1, this indicating a high level of compliance. In the case of the CBS 'Hazard band B, EPL2, CS1', exposure data are available from screen-printing firms (n = 50), optician workshops (n = 49), and from the area of furniture production (n = 13). The frequency distributions of the BWI reveal almost no instances of values being exceeded in the three branches. In a subsequent step, a Monte Carlo Simulation was employed to explore whether the BWI frequency distributions can be generalized using a probabilistic model. The frequency distributions of the exposure levels and the OELs were used as the input data for the model. The simulation results show that the model distribution, called Modellierter Bewertungsindex distribution, can reproduce the BWI distribution if the data basis is homogeneous (data from one branch) and less correlated. In case of a heterogeneous data set (pooled data from different branches), the simulation results can be interpreted as generic statements about the attainable protection level. It was found that CB does not (at least potentially) guarantee compliance in either case. On the other hand, the generic simulation showed that compliance was high for volatile liquids used in closed systems (CBS: 'hazard band C, EPL3, CS3') and for solids in the presence of local exhaust ventilation (CBS: 'hazard band B, EPS3, CS2'). PMID:19531808

  15. Novel Hybrid of LS-SVM and Kalman Filter for GPS/INS Integration

    NASA Astrophysics Data System (ADS)

    Xu, Zhenkai; Li, Yong; Rizos, Chris; Xu, Xiaosu

    Integration of Global Positioning System (GPS) and Inertial Navigation System (INS) technologies can overcome the drawbacks of the individual systems. One of the advantages is that the integrated solution can provide continuous navigation capability even during GPS outages. However, bridging the GPS outages is still a challenge when Micro-Electro-Mechanical System (MEMS) inertial sensors are used. Methods being currently explored by the research community include applying vehicle motion constraints, optimal smoother, and artificial intelligence (AI) techniques. In the research area of AI, the neural network (NN) approach has been extensively utilised up to the present. In an NN-based integrated system, a Kalman filter (KF) estimates position, velocity and attitude errors, as well as the inertial sensor errors, to output navigation solutions while GPS signals are available. At the same time, an NN is trained to map the vehicle dynamics with corresponding KF states, and to correct INS measurements when GPS measurements are unavailable. To achieve good performance it is critical to select suitable quality and an optimal number of samples for the NN. This is sometimes too rigorous a requirement which limits real world application of NN-based methods.The support vector machine (SVM) approach is based on the structural risk minimisation principle, instead of the minimised empirical error principle that is commonly implemented in an NN. The SVM can avoid local minimisation and over-fitting problems in an NN, and therefore potentially can achieve a higher level of global performance. This paper focuses on the least squares support vector machine (LS-SVM), which can solve highly nonlinear and noisy black-box modelling problems. This paper explores the application of the LS-SVM to aid the GPS/INS integrated system, especially during GPS outages. The paper describes the principles of the LS-SVM and of the KF hybrid method, and introduces the LS-SVM regression algorithm. Field test data is processed to evaluate the performance of the proposed approach.

  16. High-performance hybrid complementary logic inverter through monolithic integration of a MEMS switch and an oxide TFT.

    PubMed

    Song, Yong-Ha; Ahn, Sang-Joon Kenny; Kim, Min-Wu; Lee, Jeong-Oen; Hwang, Chi-Sun; Pi, Jae-Eun; Ko, Seung-Deok; Choi, Kwang-Wook; Park, Sang-Hee Ko; Yoon, Jun-Bo

    2015-03-25

    A hybrid complementary logic inverter consisting of a microelectromechanical system switch as a promising alternative for the p-type oxide thin film transistor (TFT) and an n-type oxide TFT is presented for ultralow power integrated circuits. These heterogeneous microdevices are monolithically integrated. The resulting logic device shows a distinctive voltage transfer characteristic curve, very low static leakage, zero-short circuit current, and exceedingly high voltage gain. PMID:25418881

  17. New integrated Monte Carlo code for the simulation of high-resolution scanning electron microscopy images for metrology in microlithography

    NASA Astrophysics Data System (ADS)

    Ilgüsatiroglu, Emre; Illarionov, Alexey Yu.; Ciappa, Mauro; Pfäffli, Paul; Bomholt, Lars

    2014-04-01

    A new Monte Carlo code is presented that includes among others definition of arbitrary geometries with sub-nanometer resolution, high performance parallel computing capabilities, trapped charge, electric field calculation, electron tracking in electrostatic field, and calculation of 3D dose distributions. These functionalities are efficiently implemented thanks to the coupling of the Monte Carlo simulator with a TCAD environment. Applications shown are the synthesis of SEM linescans and images that focus on the evaluation of the impact of proximity effects and self charging on the quantitative extraction of critical dimensions in dense photoresist structures.

  18. Electric-drive tractability indicator integrated in hybrid electric vehicle tachometer

    DOEpatents

    Tamai, Goro; Zhou, Jing; Weslati, Feisel

    2014-09-02

    An indicator, system and method of indicating electric drive usability in a hybrid electric vehicle. A tachometer is used that includes a display having an all-electric drive portion and a hybrid drive portion. The all-electric drive portion and the hybrid drive portion share a first boundary which indicates a minimum electric drive usability and a beginning of hybrid drive operation of the vehicle. The indicated level of electric drive usability is derived from at least one of a percent battery discharge, a percent maximum torque provided by the electric drive, and a percent electric drive to hybrid drive operating cost for the hybrid electric vehicle.

  19. First application close measurements applying the new hybrid integrated MEMS spectrometer

    NASA Astrophysics Data System (ADS)

    Grüger, Heinrich; Pügner, Tino; Knobbe, Jens; Schenk, Harald

    2013-05-01

    Grating spectrometers have been designed in many different configurations. Now potential high volume applications ask for extremely miniaturized and low cost systems. By the use of integrated MEMS (micro electro mechanical systems) scanning grating devices a less expensive single detector can be used in the NIR instead of the array detectors required for fixed grating systems. Meanwhile the design of a hybrid integrated MEMS scanning grating spectrometer has been drawn. The MEMS device was fabricated in the Fraunhofer IPMS own clean room facility. This chip is mounted on a small circuit board together with the detector and then stacked with spacer and mirror substrate. The spectrometer has been realized by stacking several planar substrates by sophisticated mounting technologies. The spectrometer has been designed for the 950nm - 1900nm spectral range and 9nm spectral resolution with organic matter analysis in mind. First applications are considered in the food quality analysis and food processing technology. As example for the use of a spectrometer with this performance the grill process of steak was analyzed. Similar measurement would be possible on dairy products, vegetables or fruit. The idea is a mobile spectrometer for in situ and on site analysis applications in or attached to a host system providing processing, data access and input-output capabilities, disregarding this would be a laptop, tablet, smart phone or embedded platform.

  20. Cultivating Curiosity: Integrating Hybrid Teaching in Courses in Human Behavior in the Social Environment

    ERIC Educational Resources Information Center

    Rodriguez-Keyes, Elizabeth; Schneider, Dana A.

    2013-01-01

    This study illustrates an experience of implementing a hybrid model for teaching human behavior in the social environment in an urban university setting. Developing a hybrid model in a BSW program arose out of a desire to reach students in a different way. Designed to promote curiosity and active learning, this particular hybrid model has students…

  1. Advanced Hybrid Spacesuit Concept Featuring Integrated Open Loop and Closed Loop Ventilation Systems

    NASA Technical Reports Server (NTRS)

    Daniel, Brian A.; Fitzpatrick, Garret R.; Gohmert, Dustin M.; Ybarra, Rick M.; Dub, Mark O.

    2013-01-01

    A document discusses the design and prototype of an advanced spacesuit concept that integrates the capability to function seamlessly with multiple ventilation system approaches. Traditionally, spacesuits are designed to operate both dependently and independently of a host vehicle environment control and life support system (ECLSS). Spacesuits that operate independent of vehicle-provided ECLSS services must do so with equipment selfcontained within or on the spacesuit. Suits that are dependent on vehicle-provided consumables must remain physically connected to and integrated with the vehicle to operate properly. This innovation is the design and prototype of a hybrid spacesuit approach that configures the spacesuit to seamlessly interface and integrate with either type of vehicular systems, while still maintaining the ability to function completely independent of the vehicle. An existing Advanced Crew Escape Suit (ACES) was utilized as the platform from which to develop the innovation. The ACES was retrofitted with selected components and one-off items to achieve the objective. The ventilation system concept was developed and prototyped/retrofitted to an existing ACES. Components were selected to provide suit connectors, hoses/umbilicals, internal breathing system ducting/ conduits, etc. The concept utilizes a lowpressure- drop, high-flow ventilation system that serves as a conduit from the vehicle supply into the suit, up through a neck seal, into the breathing helmet cavity, back down through the neck seal, out of the suit, and returned to the vehicle. The concept also utilizes a modified demand-based breathing system configured to function seamlessly with the low-pressure-drop closed-loop ventilation system.

  2. Monte Carlo analysis of a time-dependent neutron and secondary gamma-ray integral experiment on a thick concrete and steel shield

    NASA Astrophysics Data System (ADS)

    Cramer, S. N.; Roussin, R. W.

    1981-11-01

    A Monte Carlo analysis of a time-dependent neutron and secondary gamma-ray integral experiment on a thick concrete and steel shield is presented. The energy range covered in the analysis is 15-2 MeV for neutron source energies. The multigroup MORSE code was used with the VITAMIN C 171-36 neutron-gamma-ray cross-section data set. Both neutron and gamma-ray count rates and unfolded energy spectra are presented and compared, with good general agreement, with experimental results.

  3. A hybrid lightwave transmission system based on light injection/optoelectronic feedback techniques and fiber-VLLC integration

    NASA Astrophysics Data System (ADS)

    Tsai, Wen-Shing; Lu, Hai-Han; Li, Chung-Yi; Chen, Bo-Rui; Lin, Hung-Hsien; Lin, Dai-Hua

    2016-04-01

    A hybrid lightwave transmission system based on light injection/optoelectronic feedback techniques and fiber-visible laser light communication (VLLC) integration is proposed and experimentally demonstrated. To be the first one of its kind in employing light injection and optoelectronic feedback techniques in a fiber-VLLC integration lightwave transmission system, the light is successfully directly modulated with Community Access Television (CATV), 16-QAM, and 16-QAM-OFDM signals. Over a 40 km SMF and a 10 m free-space VLLC transport, good performances of carrier-to-noise ratio (CNR)/composite second-order (CSO)/composite triple-beat (CTB)/bit error rate (BER) are achieved for CATV/16-QAM/16-QAM-OFDM signals transmission. Such a hybrid lightwave transmission system would be very useful since it can provide broadband integrated services including CATV, Internet, and telecommunication services over both distribute fiber and in-building networks.

  4. Design and construction of a VHGT-attached WDM-type triplex transceiver module using polymer PLC hybrid integration technology

    NASA Astrophysics Data System (ADS)

    Jerbek, Vitezslav; Httel, Ivan; Prajzler, Vclav; Busek, K.; Seliger, P.

    2008-11-01

    We report about design and construction of the bidirectional transceiver TRx module for subscriber part of the passive optical network PON for a fiber to the home FTTH topology. The TRx module consists of a epoxy novolak resin polymer planar lightwave circuit (PLC) hybrid integration technology with volume holographic grating triplex filter VHGT, surface-illuminated photodetectors and spot-size converted Fabry-Prot laser diode in SMD package. The hybrid PLC has composed from a two parts-polymer optical waveguide including VHGT filter section and a optoelectronic microwave section. The both parts are placed on the composite substrate.

  5. Antenna-coupled silicon-organic hybrid integrated photonic crystal modulator for broadband electromagnetic wave detection

    NASA Astrophysics Data System (ADS)

    Zhang, Xingyu; Hosseini, Amir; Subbaraman, Harish; Wang, Shiyi; Zhan, Qiwen; Luo, Jingdong; Jen, Alex K.; Chung, Chi-jui; Yan, Hai; Pan, Zeyu; Nelson, Robert L.; Lee, Charles Y.; Chen, Ray T.

    2015-03-01

    The detection and measurement of electromagnetic fields have attracted significant amounts of attention in recent years. Traditional electronic electromagnetic field sensors use large active conductive probes which perturb the field to be measured and also make the devices bulky. In order to address these problems, integrated photonic electromagnetic field sensors have been developed, in which an optical signal is modulated by an RF signal collected by a miniaturized antenna. In this work, we design, fabricate and characterize a compact, broadband and highly sensitive integrated photonic electromagnetic field sensor based on a silicon-organic hybrid modulator driven by a bowtie antenna. The large electro-optic (EO) coefficient of organic polymer, the slow-light effects in the silicon slot photonic crystal waveguide (PCW), and the broadband field enhancement provided by the bowtie antenna, are all combined to enhance the interaction of microwaves and optical waves, enabling a high EO modulation efficiency and thus a high sensitivity. The modulator is experimentally demonstrated with a record-high effective in-device EO modulation efficiency of r33=1230pm/V. Modulation response up to 40GHz is measured, with a 3-dB bandwidth of 11GHz. The slot PCW has an interaction length of 300μm, and the bowtie antenna has an area smaller than 1cm2. The bowtie antenna in the device is experimentally demonstrated to have a broadband characteristics with a central resonance frequency of 10GHz, as well as a large beam width which enables the detection of electromagnetic waves from a large range of incident angles. The sensor is experimentally demonstrated with a minimum detectable electromagnetic power density of 8.4mW/m2 at 8.4GHz, corresponding to a minimum detectable electric field of 2.5V/m and an ultra-high sensitivity of 0.000027V/m Hz-1/2 ever demonstrated. To the best of our knowledge, this is the first silicon-organic hybrid device and also the first PCW device used for the photonic detection of electromagnetic waves. Finally, we propose some future work, including a Teraherz wave sensor based on antenna-coupled electrooptic polymer filled plasmonic slot waveguide, as well as a fully packaged and tailgated device.

  6. Diffusion-controlled evolution of core-shell nanowire arrays into integrated hybrid nanotube arrays for Li-ion batteries

    NASA Astrophysics Data System (ADS)

    Jiang, Jian; Luo, Jingshan; Zhu, Jianhui; Huang, Xintang; Liu, Jinping; Yu, Ting

    2013-08-01

    Controlled integration of multiple semiconducting oxides into each single unit of ordered nanotube arrays is highly desired in scientific research for the realization of more attractive applications. We herein report a diffusion-controlled solid-solid route to evolve simplex Co(CO3)0.5(OH)0.11H2O@TiO2 core-shell nanowire arrays (NWs) into CoO-CoTiO3 integrated hybrid nanotube arrays (NTs) with preserved morphology. During the evolution procedure, the decomposition of Co(CO3)0.5(OH)0.11H2O NWs into chains of CoCO3 nanoparticles initiates the diffusion process and promotes the interfacial solid-solid diffusion reaction even at a low temperature of 450 °C. The resulting CoO-CoTiO3 NTs possess well-defined sealed tubular geometries and a special ``inner-outer'' hybrid nature, which is suitable for application in Li-ion batteries (LIBs). As a proof-of-concept demonstration of the functions of such hybrid NTs in LIBs, CoO-CoTiO3 NTs are directly tested as LIB anodes, exhibiting both a high capacity (~600 mA h g-1 still remaining after 250 continuous cycles) and a much better cycling performance (no capacity fading within 250 total cycles) than CoO NWs. Our work presents not only a diffusion route for the formation of integrated hybrid NTs but also a new concept that can be employed as a general strategy to fabricate other oxide-based hybrid NTs for energy storage devices.Controlled integration of multiple semiconducting oxides into each single unit of ordered nanotube arrays is highly desired in scientific research for the realization of more attractive applications. We herein report a diffusion-controlled solid-solid route to evolve simplex Co(CO3)0.5(OH)0.11H2O@TiO2 core-shell nanowire arrays (NWs) into CoO-CoTiO3 integrated hybrid nanotube arrays (NTs) with preserved morphology. During the evolution procedure, the decomposition of Co(CO3)0.5(OH)0.11H2O NWs into chains of CoCO3 nanoparticles initiates the diffusion process and promotes the interfacial solid-solid diffusion reaction even at a low temperature of 450 °C. The resulting CoO-CoTiO3 NTs possess well-defined sealed tubular geometries and a special ``inner-outer'' hybrid nature, which is suitable for application in Li-ion batteries (LIBs). As a proof-of-concept demonstration of the functions of such hybrid NTs in LIBs, CoO-CoTiO3 NTs are directly tested as LIB anodes, exhibiting both a high capacity (~600 mA h g-1 still remaining after 250 continuous cycles) and a much better cycling performance (no capacity fading within 250 total cycles) than CoO NWs. Our work presents not only a diffusion route for the formation of integrated hybrid NTs but also a new concept that can be employed as a general strategy to fabricate other oxide-based hybrid NTs for energy storage devices. Electronic supplementary information (ESI) available: SEM images of Co(CO3)0.5(OH)0.11H2O NWs, SEM/TEM images of CoO-CoTiO3 hybrid nanotubes and the calculation of CoTiO3 theoretical capacity. See DOI: 10.1039/c3nr01786a

  7. Acceleration of Monte Carlo simulation of photon migration in complex heterogeneous media using Intel many-integrated core architecture.

    PubMed

    Gorshkov, Anton V; Kirillin, Mikhail Yu

    2015-08-01

    Over two decades, the Monte Carlo technique has become a gold standard in simulation of light propagation in turbid media, including biotissues. Technological solutions provide further advances of this technique. The Intel Xeon Phi coprocessor is a new type of accelerator for highly parallel general purpose computing, which allows execution of a wide range of applications without substantial code modification. We present a technical approach of porting our previously developed Monte Carlo (MC) code for simulation of light transport in tissues to the Intel Xeon Phi coprocessor. We show that employing the accelerator allows reducing computational time of MC simulation and obtaining simulation speed-up comparable to GPU. We demonstrate the performance of the developed code for simulation of light transport in the human head and determination of the measurement volume in near-infrared spectroscopy brain sensing. PMID:26249663

  8. 1-D EQUILIBRIUM DISCRETE DIFFUSION MONTE CARLO

    SciTech Connect

    T. EVANS; ET AL

    2000-08-01

    We present a new hybrid Monte Carlo method for 1-D equilibrium diffusion problems in which the radiation field coexists with matter in local thermodynamic equilibrium. This method, the Equilibrium Discrete Diffusion Monte Carlo (EqDDMC) method, combines Monte Carlo particles with spatially discrete diffusion solutions. We verify the EqDDMC method with computational results from three slab problems. The EqDDMC method represents an incremental step toward applying this hybrid methodology to non-equilibrium diffusion, where it could be simultaneously coupled to Monte Carlo transport.

  9. Misalignment tolerant couplers for hybrid integration of semiconductor lasers with silicon photonics parallel transmitters

    NASA Astrophysics Data System (ADS)

    Romero-García, S.; Marzban, B.; Sharif Azadeh, S.; Merget, F.; Shen, B.; Witzens, J.

    2014-05-01

    Hybrid integration of prefabricated III-V laser diodes with sub-micrometric silicon photonic waveguides suffers from a tradeoff between alignment tolerance and coupling efficiency. In this work, we demonstrate integrated coupling devices that substantially alleviate this problem by means of a balanced distribution of the laser power between two on-chip single mode SOI waveguides. With the reported coupling devices, a horizontal misalignment of the laser is converted in a variation of the relative phase of the light coupled into the two waveguides, allowing to satisfy the reciprocity principle while maintaining a high total coupling efficiency and a balanced power splitting. The relaxed alignment tolerances facilitate passive assembly of the lasers with pick-and-place tools. The balanced splitting of the power between waveguides is particularly well suited for optical interconnects with parallel transmitters. Here, the device design is discussed for both edge couplers and grating couplers relying on similar design principles. Furthermore, experimental characterization of edge-coupling structures with a lensed fiber and a Fabry-Pérot laser is presented. These devices have been fabricated with 193nm DUV optical lithography and are compatible with mainstream CMOS technology. The edge couplers with the best horizontal misalignment exhibits an excellent 1 dB loss horizontal misalignment range of 3.8 μm with excess insertion losses below 3.1 dB (in addition to the 3dB splitting). The back-reflection induced by the device has been assessed to be below -20 dB and measured relative intensity noise is better than measured from the same laser coupled to a lensed fiber.

  10. Hybrid Finite Element-Fast Spectral Domain Multilayer Boundary Integral Modeling of Doubly Periodic Structures

    SciTech Connect

    T.F. Eibert; J.L. Volakis; Y.E. Erdemli

    2002-03-03

    Hybrid finite element (FE)--boundary integral (BI) analysis of infinite periodic arrays is extended to include planar multilayered Green's functions. In this manner, a portion of the volumetric dielectric region can be modeled via the finite element method whereas uniform multilayered regions can be modeled using a multilayered Green's function. As such, thick uniform substrates can be modeled without loss of efficiency and accuracy. The multilayered Green's function is analytically computed in the spectral domain and the resulting BI matrix-vector products are evaluated via the fast spectral domain algorithm (FSDA). As a result, the computational cost of the matrix-vector products is kept at O(N). Furthermore, the number of Floquet modes in the expansion are kept very few by placing the BI surfaces within the computational unit cell. Examples of frequency selective surface (FSS) arrays are analyzed with this method to demonstrate the accuracy and capability of the approach. One example involves complicated multilayered substrates above and below an inhomogeneous filter element and the other is an optical ring-slot array on a substrate several hundred wavelengths in thickness. Comparisons with measurements are included.

  11. Integrating molecular, phenotypic and environmental data to elucidate patterns of crocodile hybridization in Belize.

    PubMed

    Hekkala, Evon R; Platt, Steven G; Thorbjarnarson, John B; Rainwater, Thomas R; Tessler, Michael; Cunningham, Seth W; Twomey, Christopher; Amato, George

    2015-09-01

    The genus Crocodylus comprises 12 currently recognized species, many of which can be difficult to differentiate phenotypically. Interspecific hybridization among crocodiles is known to occur in captivity and has been documented between some species in the wild. The identification of hybrid individuals is of importance for management and monitoring of crocodilians, many of which are Convention on International Trade in Endangered Species (CITES) listed. In this study, both mitochondrial and nuclear DNA markers were evaluated for their use in confirming a suspected hybrid zone between American crocodile (Crocodylus acutus) and Morelet's crocodile (Crocodylus moreletii) populations in southern Belize where individuals and nests exhibiting atypical phenotypic features had previously been observed. Patterns observed in both phenotypic and molecular data indicate possible behavioural and ecological characteristics associated with hybridization events. The results of the combined analyses found that the majority of suspected hybrid samples represent crosses between female C. acutus and male C. moreletii. Phenotypic data could statistically identify hybrids, although morphological overlap between hybrids and C. moreletii reduced reliability of identification based solely on field characters. Ecologically, C. acutus was exclusively found in saline waters, whereas hybrids and C. moreletii were largely absent in these conditions. A hypothesized correlation between unidirectional hybridization and destruction of C. acutus breeding habitats warrants additional research. PMID:26473062

  12. Integrating molecular, phenotypic and environmental data to elucidate patterns of crocodile hybridization in Belize

    PubMed Central

    Hekkala, Evon R.; Platt, Steven G.; Thorbjarnarson, John B.; Rainwater, Thomas R.; Tessler, Michael; Cunningham, Seth W.; Twomey, Christopher; Amato, George

    2015-01-01

    The genus Crocodylus comprises 12 currently recognized species, many of which can be difficult to differentiate phenotypically. Interspecific hybridization among crocodiles is known to occur in captivity and has been documented between some species in the wild. The identification of hybrid individuals is of importance for management and monitoring of crocodilians, many of which are Convention on International Trade in Endangered Species (CITES) listed. In this study, both mitochondrial and nuclear DNA markers were evaluated for their use in confirming a suspected hybrid zone between American crocodile (Crocodylus acutus) and Morelet’s crocodile (Crocodylus moreletii) populations in southern Belize where individuals and nests exhibiting atypical phenotypic features had previously been observed. Patterns observed in both phenotypic and molecular data indicate possible behavioural and ecological characteristics associated with hybridization events. The results of the combined analyses found that the majority of suspected hybrid samples represent crosses between female C. acutus and male C. moreletii. Phenotypic data could statistically identify hybrids, although morphological overlap between hybrids and C. moreletii reduced reliability of identification based solely on field characters. Ecologically, C. acutus was exclusively found in saline waters, whereas hybrids and C. moreletii were largely absent in these conditions. A hypothesized correlation between unidirectional hybridization and destruction of C. acutus breeding habitats warrants additional research. PMID:26473062

  13. HiRel: Hybrid Automated Reliability Predictor (HARP) integrated reliability tool system, (version 7.0). Volume 2: HARP tutorial

    NASA Technical Reports Server (NTRS)

    Rothmann, Elizabeth; Dugan, Joanne Bechta; Trivedi, Kishor S.; Mittal, Nitin; Bavuso, Salvatore J.

    1994-01-01

    The Hybrid Automated Reliability Predictor (HARP) integrated Reliability (HiRel) tool system for reliability/availability prediction offers a toolbox of integrated reliability/availability programs that can be used to customize the user's application in a workstation or nonworkstation environment. The Hybrid Automated Reliability Predictor (HARP) tutorial provides insight into HARP modeling techniques and the interactive textual prompting input language via a step-by-step explanation and demonstration of HARP's fault occurrence/repair model and the fault/error handling models. Example applications are worked in their entirety and the HARP tabular output data are presented for each. Simple models are presented at first with each succeeding example demonstrating greater modeling power and complexity. This document is not intended to present the theoretical and mathematical basis for HARP.

  14. ITS Version 3.0: The Integrated TIGER Series of coupled electron/photon Monte Carlo transport codes

    SciTech Connect

    Halbleib, J.A.; Kensek, R.P.; Valdez, G.D.; Mehlhorn, T.A.; Seltzer, S.M.; Berger, M.J.

    1993-06-01

    ITS is a powerful and user-friendly software package permitting state-of-the-art Monte Carlo solution of linear time-independent coupled electron/photon radiation transport problems, with or without the presence of macroscopic electric and magnetic fields. It combines operational simplicity and physical accuracy in order to provide experimentalists and theorists alike with a method for the routine but rigorous solution of sophisticated radiation transport problems. Flexibility of construction permits tailoring of the codes to specific applications and extension of code capabilities to more complex applications through simple update procedures.

  15. Optical, mechanical and electronic design and integration of POMM, a polarimeter for the Observatoire du mont Mégantic

    NASA Astrophysics Data System (ADS)

    Leclerc, Melanie R.; Côté, Patrice; Duchesne, François; Bastien, Pierre; Hernandez, Olivier; Colonna d'Istria, Pierre; Demers, Mathieu; Girard, Marc; Savard, Maxime; Lemieux, Dany; Thibault, Simon; Brousseau, Denis

    2014-08-01

    A polarimeter, to observe exoplanets in the visible and infrared, was built for the "Observatoire du Mont Mégantic" (OMM) to replace an existing instrument and reach 10-6 precision, a factor 100 improvement. The optical and mechanical designs are presented, with techniques used to precisely align the optical components and rotation axes to achieve the targeted precision. A photo-elastic modulator (PEM) and a lock-in amplifier are used to measure the polarization. The typical signal is a high DC superimposed to a very faint sinusoidal oscillation. Custom electronics was developed to measure the AC and DC amplitudes, and characterization results are presented.

  16. Project Integration Office for the electric and hybrid vehicle R and D program. Eighth progress report, March 1982

    SciTech Connect

    Not Available

    1982-04-19

    The Project Integration Office (PIO) was established to assist the US DOE with the direction and coordination of its multiple electric vehicle and hybrid electric vehicle research programs in order to get the maximum payoff from these research efforts. In addition, the PIO performs objective independent technical and economic studies, analyses and modeling, and maintains a technical information liaison service to facilitate information exchange between the program participants and industry. Progress in each of these activities is reported. (LCL)

  17. Hybrid materials science: a promised land for the integrative design of multifunctional materials

    NASA Astrophysics Data System (ADS)

    Nicole, Lionel; Laberty-Robert, Christel; Rozes, Laurence; Sanchez, Clément

    2014-05-01

    For more than 5000 years, organic-inorganic composite materials created by men via skill and serendipity have been part of human culture and customs. The concept of ``hybrid organic-inorganic'' nanocomposites exploded in the second half of the 20th century with the expansion of the so-called ``chimie douce'' which led to many collaborations between a large set of chemists, physicists and biologists. Consequently, the scientific melting pot of these very different scientific communities created a new pluridisciplinary school of thought. Today, the tremendous effort of basic research performed in the last twenty years allows tailor-made multifunctional hybrid materials with perfect control over composition, structure and shape. Some of these hybrid materials have already entered the industrial market. Many tailor-made multiscale hybrids are increasingly impacting numerous fields of applications: optics, catalysis, energy, environment, nanomedicine, etc. In the present feature article, we emphasize several fundamental and applied aspects of the hybrid materials field: bioreplication, mesostructured thin films, Lego-like chemistry designed hybrid nanocomposites, and advanced hybrid materials for energy. Finally, a few commercial applications of hybrid materials will be presented.

  18. Integrating Quality Matters into Hybrid Course Design: A Principles of Marketing Case Study

    ERIC Educational Resources Information Center

    Young, Mark R.

    2014-01-01

    Previous research supports the idea that the success of hybrid or online delivery modes is more a function of course design than delivery media. This article describes a case study of a hybrid Principles of Marketing course that implemented a comprehensive redesign based on design principles espoused by the Quality Matters Program, a center for

  19. Integrating Quality Matters into Hybrid Course Design: A Principles of Marketing Case Study

    ERIC Educational Resources Information Center

    Young, Mark R.

    2014-01-01

    Previous research supports the idea that the success of hybrid or online delivery modes is more a function of course design than delivery media. This article describes a case study of a hybrid Principles of Marketing course that implemented a comprehensive redesign based on design principles espoused by the Quality Matters Program, a center for…

  20. High-Throughput Multiple Dies-to-Wafer Bonding Technology and III/V-on-Si Hybrid Lasers for Heterogeneous Integration of Optoelectronic Integrated Circuits

    NASA Astrophysics Data System (ADS)

    Luo, Xianshu; Cao, Yulian; Song, Junfeng; Hu, Xiaonan; Cheng, Yungbing; Li, Chengming; Liu, Chongyang; Liow, Tsung-Yang; Yu, Mingbin; Wang, Hong; Wang, Qijie; Lo, Patrick Guo-Qiang

    2015-04-01

    Integrated optical light source on silicon is one of the key building blocks for optical interconnect technology. Great research efforts have been devoting worldwide to explore various approaches to integrate optical light source onto the silicon substrate. The achievements so far include the successful demonstration of III/V-on-Si hybrid lasers through III/V-gain material to silicon wafer bonding technology. However, for potential large-scale integration, leveraging on mature silicon complementary metal oxide semiconductor (CMOS) fabrication technology and infrastructure, more effective bonding scheme with high bonding yield is in great demand considering manufacturing needs. In this paper, we propose and demonstrate a high-throughput multiple dies-to-wafer (D2W) bonding technology which is then applied for the demonstration of hybrid silicon lasers. By temporarily bonding III/V dies to a handle silicon wafer for simultaneous batch processing, it is expected to bond unlimited III/V dies to silicon device wafer with high yield. As proof-of-concept, more than 100 III/V dies bonding to 200 mm silicon wafer is demonstrated. The high performance of the bonding interface is examined with various characterization techniques. Repeatable demonstrations of 16-III/V-die bonding to pre-patterned 200 mm silicon wafers have been performed for various hybrid silicon lasers, in which device library including Fabry-Perot (FP) laser, lateral-coupled distributed feedback (LC-DFB) laser with side wall grating, and mode-locked laser (MLL). From these results, the presented multiple D2W bonding technology can be a key enabler towards the large-scale heterogeneous integration of optoelectronic integrated circuits (H-OEIC).

  1. Assessment of radiation shield integrity of DD/DT fusion neutron generator facilities by Monte Carlo and experimental methods

    NASA Astrophysics Data System (ADS)

    Srinivasan, P.; Priya, S.; Patel, Tarun; Gopalakrishnan, R. K.; Sharma, D. N.

    2015-01-01

    DD/DT fusion neutron generators are used as sources of 2.5 MeV/14.1 MeV neutrons in experimental laboratories for various applications. Detailed knowledge of the radiation dose rates around the neutron generators are essential for ensuring radiological protection of the personnel involved with the operation. This work describes the experimental and Monte Carlo studies carried out in the Purnima Neutron Generator facility of the Bhabha Atomic Research Center (BARC), Mumbai. Verification and validation of the shielding adequacy was carried out by measuring the neutron and gamma dose-rates at various locations inside and outside the neutron generator hall during different operational conditions both for 2.5-MeV and 14.1-MeV neutrons and comparing with theoretical simulations. The calculated and experimental dose rates were found to agree with a maximum deviation of 20% at certain locations. This study has served in benchmarking the Monte Carlo simulation methods adopted for shield design of such facilities. This has also helped in augmenting the existing shield thickness to reduce the neutron and associated gamma dose rates for radiological protection of personnel during operation of the generators at higher source neutron yields up to 1 × 1010 n/s.

  2. Hybrid Environmental Control System Integrated Modeling Trade Study Analysis for Commercial Aviation

    NASA Astrophysics Data System (ADS)

    Parrilla, Javier

    Current industry trends demonstrate aircraft electrification will be part of future platforms in order to achieve higher levels of efficiency in various vehicle level sub-systems. However electrification requires a substantial change in aircraft design that is not suitable for re-winged or re-engined applications as some aircraft manufacturers are opting for today. Thermal limits arise as engine cores progressively get smaller and hotter to improve overall engine efficiency, while legacy systems still demand a substantial amount of pneumatic, hydraulic and electric power extraction. The environmental control system (ECS) provides pressurization, ventilation and air conditioning in commercial aircraft, making it the main heat sink for all aircraft loads with exception of the engine. To mitigate the architecture thermal limits in an efficient manner, the form in which the ECS interacts with the engine will have to be enhanced as to reduce the overall energy consumed and achieve an energy optimized solution. This study examines a tradeoff analysis of an electric ECS by use of a fully integrated Numerical Propulsion Simulation System (NPSS) model that is capable of studying the interaction between the ECS and the engine cycle deck. It was found that a peak solution lays in a hybrid ECS where it utilizes the correct balance between a traditional pneumatic and a fully electric system. This intermediate architecture offers a substantial improvement in aircraft fuel consumptions due to a reduced amount of waste heat and customer bleed in exchange for partial electrification of the air-conditions pack which is a viable option for re-winged applications.

  3. An integrated hybrid microfluidic device for oviposition-based chemical screening of adult Drosophila melanogaster.

    PubMed

    Leung, Jacob C K; Hilliker, Arthur J; Rezai, Pouya

    2016-02-21

    Chemical screening using Drosophila melanogaster (the fruit fly) is vital in drug discovery, agricultural, and toxicological applications. Oviposition (egg laying) on chemically-doped agar plates is an important read-out metric used to quantitatively assess the biological fitness and behavioral responses of Drosophila. Current oviposition-based chemical screening studies are inaccurate, labor-intensive, time-consuming, and inflexible due to the manual chemical doping of agar. In this paper, we have developed a novel hybrid agar-polydimethylsiloxane (PDMS) microfluidic device for single- and multi-concentration chemical dosing and on-chip oviposition screening of free-flying adult stage Drosophila. To achieve this, we have devised a novel technique to integrate agar with PDMS channels using ice as a sacrificial layer. Subsequently, we have conducted single-chemical toxicity and multiple choice chemical preference assays on adult Drosophila melanogaster using zinc and acetic acid at various concentrations. Our device has enabled us to 1) demonstrate that Drosophila is capable of sensing the concentration of different chemicals on a PDMS-agar microfluidic device, which plays significant roles in determining oviposition site selection and 2) investigate whether oviposition preference differs between single- and multi-concentration chemical environments. This device may be used to study fundamental and applied biological questions in Drosophila and other egg laying insects. It can also be extended in design to develop sophisticated and dynamic chemical dosing and high-throughput screening platforms in the future that are not easily achievable with the existing oviposition screening techniques. PMID:26768402

  4. An Improved Solution for Integrated Array Optics in Quasi-Optical mm and Submm Receivers: the Hybrid Antenna

    NASA Technical Reports Server (NTRS)

    Buttgenbach, Thomas H.

    1993-01-01

    The hybrid antenna discussed here is defined as a dielectric lens-antenna as a special case of an extended hemi-spherical dielectric lens that is operated in the diffraction limited regime. It is a modified version of the planar antenna on a lens scheme developed by Rutledge. The dielectric lens-antenna is fed by a planar-structure antenna, which is mounted on the flat side of the dielectric lens-antenna using it as a substrate, and the combination is termed a hybrid antenna. Beam pattern and aperture efficiency measurements were made at millimeter and submillimeter wavelengths as a function of extension of the hemi- spherical lens and different lens sizes. An optimum extension distance is found experimentally and numerically for which excellent beam patterns and simultaneously high aperture efficiencies can be achieved. At 115 GHz the aperture efficiency was measured to be (76 4 +/- 6) % for a diffraction limited beam with sidelobes below -17 dB. Results of a single hybrid antenna with an integrated Superconductor-Insulator-Superconductor (SIS) detector and a broad-band matching structure at submillimeter wavelengths are presented. The hybrid antenna is diffraction limited, space efficient in an array due to its high aperture efficiency, and is easily mass produced, thus being well suited for focal plane heterodyne receiver arrays.

  5. INS/GPS/LiDAR Integrated Navigation System for Urban and Indoor Environments Using Hybrid Scan Matching Algorithm

    PubMed Central

    Gao, Yanbin; Liu, Shifei; Atia, Mohamed M.; Noureldin, Aboelmagd

    2015-01-01

    This paper takes advantage of the complementary characteristics of Global Positioning System (GPS) and Light Detection and Ranging (LiDAR) to provide periodic corrections to Inertial Navigation System (INS) alternatively in different environmental conditions. In open sky, where GPS signals are available and LiDAR measurements are sparse, GPS is integrated with INS. Meanwhile, in confined outdoor environments and indoors, where GPS is unreliable or unavailable and LiDAR measurements are rich, LiDAR replaces GPS to integrate with INS. This paper also proposes an innovative hybrid scan matching algorithm that combines the feature-based scan matching method and Iterative Closest Point (ICP) based scan matching method. The algorithm can work and transit between two modes depending on the number of matched line features over two scans, thus achieving efficiency and robustness concurrently. Two integration schemes of INS and LiDAR with hybrid scan matching algorithm are implemented and compared. Real experiments are performed on an Unmanned Ground Vehicle (UGV) for both outdoor and indoor environments. Experimental results show that the multi-sensor integrated system can remain sub-meter navigation accuracy during the whole trajectory. PMID:26389906

  6. INS/GPS/LiDAR Integrated Navigation System for Urban and Indoor Environments Using Hybrid Scan Matching Algorithm.

    PubMed

    Gao, Yanbin; Liu, Shifei; Atia, Mohamed M; Noureldin, Aboelmagd

    2015-01-01

    This paper takes advantage of the complementary characteristics of Global Positioning System (GPS) and Light Detection and Ranging (LiDAR) to provide periodic corrections to Inertial Navigation System (INS) alternatively in different environmental conditions. In open sky, where GPS signals are available and LiDAR measurements are sparse, GPS is integrated with INS. Meanwhile, in confined outdoor environments and indoors, where GPS is unreliable or unavailable and LiDAR measurements are rich, LiDAR replaces GPS to integrate with INS. This paper also proposes an innovative hybrid scan matching algorithm that combines the feature-based scan matching method and Iterative Closest Point (ICP) based scan matching method. The algorithm can work and transit between two modes depending on the number of matched line features over two scans, thus achieving efficiency and robustness concurrently. Two integration schemes of INS and LiDAR with hybrid scan matching algorithm are implemented and compared. Real experiments are performed on an Unmanned Ground Vehicle (UGV) for both outdoor and indoor environments. Experimental results show that the multi-sensor integrated system can remain sub-meter navigation accuracy during the whole trajectory. PMID:26389906

  7. Integration of a particle-particle-particle-mesh algorithm with the ensemble Monte Carlo method for the simulation of ultra-small semiconductor devices

    SciTech Connect

    Wordelman, C.J.; Ravaioli, U.

    2000-02-01

    A particle-particle-particle-mesh (P{sup 3}M) algorithm is integrated with the ensemble Monte Carlo (EMC) method for the treatment of carrier-impurity (c-i) and carrier-carrier (c-c) effects in semiconductor device simulation. Ionized impurities and charge carriers are treated granularly as opposed to the normal continuum methods and c-i and c-c interactions are calculated in three dimensions. The combined P{sup 3}M-EMC method follows the approach of Hockney, but is modified to treat nonuniform rectilinear meshes with arbitrary boundary conditions. Bulk mobility results are obtained for a three-dimensional (3-D) resistor and are compared with previously reported experimental and numerical results.

  8. Grand canonical Monte Carlo and modified singlet integral equations for the density profile of a Yukawa fluid near a planar wall

    NASA Astrophysics Data System (ADS)

    Olivares-Rivas, Wilmer; Degrève, Léo; Henderson, Douglas; Quintana, Jacqueline

    1997-05-01

    Results for the density profile for Yukawa molecules near a hard wall and an exponential attractive wall are presented for Grand Canonical Monte Carlo (GCMC) simulations, for the singlet hypernetted chain (HNC) integral equation and for a modified version of the Lovett-Mou-Buff-Wertheim (LMBW-1) which uses the exact contact value theorem. The results of the standard singlet HNC are quite poor. If the LMBW equation is modified (but still using the bulk direct correlation function) the results at high temperature become reasonable. However, the results at low temperatures, close to the bulk coexistence curve, are only a partial improvement. The contact value of the density profile is now quite good but the profile has the incorrect oscillatory behavior predicted by the unmodified approximate equation. The GCMC simulation results show a clear effect of drying at low temperatures.

  9. Novel Monte Carlo approach quantifies data assemblage utility and reveals power of integrating molecular and clinical information for cancer prognosis

    PubMed Central

    Verleyen, Wim; Langdon, Simon P.; Faratian, Dana; Harrison, David J.; Smith, V. Anne

    2015-01-01

    Current clinical practice in cancer stratifies patients based on tumour histology to determine prognosis. Molecular profiling has been hailed as the path towards personalised care, but molecular data are still typically analysed independently of known clinical information. Conventional clinical and histopathological data, if used, are added only to improve a molecular prediction, placing a high burden upon molecular data to be informative in isolation. Here, we develop a novel Monte Carlo analysis to evaluate the usefulness of data assemblages. We applied our analysis to varying assemblages of clinical data and molecular data in an ovarian cancer dataset, evaluating their ability to discriminate one-year progression-free survival (PFS) and three-year overall survival (OS). We found that Cox proportional hazard regression models based on both data types together provided greater discriminative ability than either alone. In particular, we show that proteomics data assemblages that alone were uninformative (p?=?0.245 for PFS, p?=?0.526 for OS) became informative when combined with clinical information (p?=?0.022 for PFS, p?=?0.048 for OS). Thus, concurrent analysis of clinical and molecular data enables exploitation of prognosis-relevant information that may not be accessible from independent analysis of these data types. PMID:26503707

  10. ITS version 5.0 : the integrated TIGER series of coupled electron/photon Monte Carlo transport codes.

    SciTech Connect

    Franke, Brian Claude; Kensek, Ronald Patrick; Laub, Thomas William

    2004-06-01

    ITS is a powerful and user-friendly software package permitting state of the art Monte Carlo solution of linear time-independent couple electron/photon radiation transport problems, with or without the presence of macroscopic electric and magnetic fields of arbitrary spatial dependence. Our goal has been to simultaneously maximize operational simplicity and physical accuracy. Through a set of preprocessor directives, the user selects one of the many ITS codes. The ease with which the makefile system is applied combines with an input scheme based on order-independent descriptive keywords that makes maximum use of defaults and internal error checking to provide experimentalists and theorists alike with a method for the routine but rigorous solution of sophisticated radiation transport problems. Physical rigor is provided by employing accurate cross sections, sampling distributions, and physical models for describing the production and transport of the electron/photon cascade from 1.0 GeV down to 1.0 keV. The availability of source code permits the more sophisticated user to tailor the codes to specific applications and to extend the capabilities of the codes to more complex applications. Version 5.0, the latest version of ITS, contains (1) improvements to the ITS 3.0 continuous-energy codes, (2)multigroup codes with adjoint transport capabilities, and (3) parallel implementations of all ITS codes. Moreover the general user friendliness of the software has been enhanced through increased internal error checking and improved code portability.

  11. Assessment of the dynamics of Asian and European option on the hybrid system

    NASA Astrophysics Data System (ADS)

    Bogdanov, A. V.; Stepanov, E. A.; Khmel, D. S.

    2016-02-01

    In this article the problem of performance optimization for estimation of European and Asian options pricing is discussed. The main goal is to substantially improve the performance in solving the problems on the hybrid system. The authors optimized the algorithms of the Monte Carlo method for solving stochastic differential equations and path integral derived from Black-Scholes model for pricing options.

  12. A hybrid approach to survival model building using integration of clinical and molecular information in censored data.

    PubMed

    Choi, Ickwon; Kattan, Michael W; Wells, Brian J; Yu, Changhong

    2012-01-01

    In medical society, the prognostic models, which use clinicopathologic features and predict prognosis after a certain treatment, have been externally validated and used in practice. In recent years, most research has focused on high dimensional genomic data and small sample sizes. Since clinically similar but molecularly heterogeneous tumors may produce different clinical outcomes, the combination of clinical and genomic information, which may be complementary, is crucial to improve the quality of prognostic predictions. However, there is a lack of an integrating scheme for clinic-genomic models due to the P ? N problem, in particular, for a parsimonious model. We propose a methodology to build a reduced yet accurate integrative model using a hybrid approach based on the Cox regression model, which uses several dimension reduction techniques, L? penalized maximum likelihood estimation (PMLE), and resampling methods to tackle the problem. The predictive accuracy of the modeling approach is assessed by several metrics via an independent and thorough scheme to compare competing methods. In breast cancer data studies on a metastasis and death event, we show that the proposed methodology can improve prediction accuracy and build a final model with a hybrid signature that is parsimonious when integrating both types of variables. PMID:22350208

  13. Hybrid CATV/MMW/BB lightwave transmission system based on fiber-wired/fiber-wireless/fiber-VLLC integrations.

    PubMed

    Li, Chung-Yi; Lu, Hai-Han; Lu, Ting-Chieh; Chu, Chien-An; Chen, Bo-Rui; Lin, Chun-Yu; Peng, Peng-Chun

    2015-12-14

    A hybrid lightwave transmission system for cable television (CATV)/millimeter-wave (MMW)/baseband (BB) signal transmission based on fiber-wired/fiber-wireless/fiber-visible laser light communication (VLLC) integrations is proposed and demonstrated. For down-link transmission, the light is intensity-modulated with 50-550 MHz CATV signal and optically promoted from 25 GHz radio frequency (RF) signal to 10 Gbps/50 GHz and 20 Gbps/100 GHz MMW data signals based on fiber-wired and fiber-wireless integrations. Good performances of carrier-to-noise ratio (CNR), composite second-order (CSO), composite triple-beat (CTB), and bit error rate (BER) are obtained over a 40-km single-mode fiber (SMF) and a 10-m RF wireless transport. For up-link transmission, the light is successfully intensity-remodulated with 5-Gbps BB data stream based on fiber-VLLC integration. Good BER performance is achieved over a 40-km SMF and a 10-m free-space VLLC transport. Such a hybrid CATV/MMW/BB lightwave transmission system is an attractive alternative, it gives the benefits of a communication link for broader bandwidth and higher transmission rate. PMID:26698972

  14. Integration and evaluation of automated Monte Carlo simulations in the clinical practice of scanned proton and carbon ion beam therapy

    NASA Astrophysics Data System (ADS)

    Bauer, J.; Sommerer, F.; Mairani, A.; Unholtz, D.; Farook, R.; Handrack, J.; Frey, K.; Marcelos, T.; Tessonnier, T.; Ecker, S.; Ackermann, B.; Ellerbrock, M.; Debus, J.; Parodi, K.

    2014-08-01

    Monte Carlo (MC) simulations of beam interaction and transport in matter are increasingly considered as essential tools to support several aspects of radiation therapy. Despite the vast application of MC to photon therapy and scattered proton therapy, clinical experience in scanned ion beam therapy is still scarce. This is especially the case for ions heavier than protons, which pose additional issues like nuclear fragmentation and varying biological effectiveness. In this work, we present the evaluation of a dedicated framework which has been developed at the Heidelberg Ion Beam Therapy Center to provide automated FLUKA MC simulations of clinical patient treatments with scanned proton and carbon ion beams. Investigations on the number of transported primaries and the dimension of the geometry and scoring grids have been performed for a representative class of patient cases in order to provide recommendations on the simulation settings, showing that recommendations derived from the experience in proton therapy cannot be directly translated to the case of carbon ion beams. The MC results with the optimized settings have been compared to the calculations of the analytical treatment planning system (TPS), showing that regardless of the consistency of the two systems (in terms of beam model in water and range calculation in different materials) relevant differences can be found in dosimetric quantities and range, especially in the case of heterogeneous and deep seated treatment sites depending on the ion beam species and energies, homogeneity of the traversed tissue and size of the treated volume. The analysis of typical TPS speed-up approximations highlighted effects which deserve accurate treatment, in contrast to adequate beam model simplifications for scanned ion beam therapy. In terms of biological dose calculations, the investigation of the mixed field components in realistic anatomical situations confirmed the findings of previous groups so far reported only in homogenous water targets. This work can thus be useful to other centers commencing clinical experience in scanned ion beam therapy.

  15. An integrated Markov chain Monte Carlo algorithm for upscaling hydrological and geochemical parameters from column to field scale.

    PubMed

    Arora, Bhavna; Mohanty, Binayak P; McGuire, Jennifer T

    2015-04-15

    Predicting and controlling the concentrations of redox-sensitive elements are primary concerns for environmental remediation of contaminated sites. These predictions are complicated by dynamic flow processes as hydrologic variability is a governing control on conservative and reactive chemical concentrations. Subsurface heterogeneity in the form of layers and lenses further complicates the flow dynamics of the system impacting chemical concentrations including redox-sensitive elements. In response to these complexities, this study investigates the role of heterogeneity and hydrologic processes in an effective parameter upscaling scheme from the column to the landfill scale. We used a Markov chain Monte Carlo (MCMC) algorithm to derive upscaling coefficients for hydrological and geochemical parameters, which were tested for variations across heterogeneous systems (layers and lenses) and interaction of flow processes based on the output uncertainty of dominant biogeochemical concentrations at the Norman Landfill site, a closed municipal landfill with prevalent organic and trace metal contamination. The results from MCMC analysis indicated that geochemical upscaling coefficients based on effective concentration ratios incorporating local heterogeneity across layered and lensed systems produced better estimates of redox-sensitive biogeochemistry at the field scale. MCMC analysis also suggested that inclusion of hydrological parameters in the upscaling scheme reduced the output uncertainty of effective mean geochemical concentrations by orders of magnitude at the Norman Landfill site. This was further confirmed by posterior density plots of the scaling coefficients that revealed unimodal characteristics when only geochemical processes were involved, but produced multimodal distributions when hydrological parameters were included. The multimodality again suggests the effect of heterogeneity and lithologic variability on the distribution of redox-sensitive elements at the Norman Landfill site. PMID:25644839

  16. A hybrid model for low pressure inductively coupled plasmas combining a fluid model for electrons with a plasma-potential-dependent energy distribution and a fluid-Monte Carlo model for ions

    NASA Astrophysics Data System (ADS)

    Mouchtouris, S.; Kokkoris, G.

    2016-04-01

    A hybrid plasma model is utilized for the simulation of inductively coupled plasmas (ICPs). It consists of a plasma fluid model coupling fluid with Maxwell’s equations and a Monte Carlo (MC) particle tracing model utilized for the calculation of the ion mobility in high electrostatic fields (sheaths). The model is applied to low pressure Argon plasma in the gaseous electronics conference (GEC) reference cell. Following measurements of electron energy distribution function (EEDF) in low pressure ICPs, a three-temperature EEDF is considered; it is formulated with a generalized equation and depends on the local plasma potential. The use of a predefined formula for the EEDF entails a low computational cost: All parameters affected by the EEDF are calculated as functions of the plasma potential and the mean electron energy once and before the solution of the model. The model results are validated by a comparison with spatially resolved (on axial and radial distance) measurements of electron density, electron temperature, and plasma potential. Both the calculation of the ion mobility by the MC model and the consideration of the three-temperature EEDF are critical for the accuracy of the model results. The very good agreement of the model results with the measurements and the low computational cost in combination with the flexibility of the code utilized for the numerical solution manifest the potential of the hybrid plasma model for the simulation of low pressure ICPs.

  17. Hybrid adeno-associated viral vectors utilizing transposase-mediated somatic integration for stable transgene expression in human cells.

    PubMed

    Zhang, Wenli; Solanki, Manish; Müther, Nadine; Ebel, Melanie; Wang, Jichang; Sun, Chuanbo; Izsvak, Zsuzsanna; Ehrhardt, Anja

    2013-01-01

    Recombinant adeno-associated viral (AAV) vectors have been shown to be one of the most promising vectors for therapeutic gene delivery because they can induce efficient and long-term transduction in non-dividing cells with negligible side-effects. However, as AAV vectors mostly remain episomal, vector genomes and transgene expression are lost in dividing cells. Therefore, to stably transduce cells, we developed a novel AAV/transposase hybrid-vector. To facilitate SB-mediated transposition from the rAAV genome, we established a system in which one AAV vector contains the transposon with the gene of interest and the second vector delivers the hyperactive Sleeping Beauty (SB) transposase SB100X. Human cells were infected with the AAV-transposon vector and the transposase was provided in trans either by transient and stable plasmid transfection or by AAV vector transduction. We found that groups which received the hyperactive transposase SB100X showed significantly increased colony forming numbers indicating enhanced integration efficiencies. Furthermore, we found that transgene copy numbers in transduced cells were dose-dependent and that predominantly SB transposase-mediated transposition contributed to stabilization of the transgene. Based on a plasmid rescue strategy and a linear-amplification mediated PCR (LAM-PCR) protocol we analysed the SB100X-mediated integration profile after transposition from the AAV vector. A total of 1840 integration events were identified which revealed a close to random integration profile. In summary, we show for the first time that AAV vectors can serve as template for SB transposase mediated somatic integration. We developed the first prototype of this hybrid-vector system which with further improvements may be explored for treatment of diseases which originate from rapidly dividing cells. PMID:24116154

  18. A Monte Carlo Approach to Modeling the Breakup of the Space Launch System EM-1 Core Stage with an Integrated Blast and Fragment Catalogue

    NASA Technical Reports Server (NTRS)

    Richardson, Erin; Hays, M. J.; Blackwood, J. M.; Skinner, T.

    2014-01-01

    The Liquid Propellant Fragment Overpressure Acceleration Model (L-FOAM) is a tool developed by Bangham Engineering Incorporated (BEi) that produces a representative debris cloud from an exploding liquid-propellant launch vehicle. Here it is applied to the Core Stage (CS) of the National Aeronautics and Space Administration (NASA) Space Launch System (SLS launch vehicle). A combination of Probability Density Functions (PDF) based on empirical data from rocket accidents and applicable tests, as well as SLS specific geometry are combined in a MATLAB script to create unique fragment catalogues each time L-FOAM is run-tailored for a Monte Carlo approach for risk analysis. By accelerating the debris catalogue with the BEi blast model for liquid hydrogen / liquid oxygen explosions, the result is a fully integrated code that models the destruction of the CS at a given point in its trajectory and generates hundreds of individual fragment catalogues with initial imparted velocities. The BEi blast model provides the blast size (radius) and strength (overpressure) as probabilities based on empirical data and anchored with analytical work. The coupling of the L-FOAM catalogue with the BEi blast model is validated with a simulation of the Project PYRO S-IV destruct test. When running a Monte Carlo simulation, L-FOAM can accelerate all catalogues with the same blast (mean blast, 2 s blast, etc.), or vary the blast size and strength based on their respective probabilities. L-FOAM then propagates these fragments until impact with the earth. Results from L-FOAM include a description of each fragment (dimensions, weight, ballistic coefficient, type and initial location on the rocket), imparted velocity from the blast, and impact data depending on user desired application. LFOAM application is for both near-field (fragment impact to escaping crew capsule) and far-field (fragment ground impact footprint) safety considerations. The user is thus able to use statistics from a Monte Carlo set of L-FOAM catalogues to quantify risk for a multitude of potential CS destruct scenarios. Examples include the effect of warning time on the survivability of an escaping crew capsule or the maximum fragment velocities generated by the ignition of leaking propellants in internal cavities.

  19. A high-resolution cat radiation hybrid and integrated FISH mapping resource for phylogenomic studies across Felidae.

    PubMed

    Davis, Brian W; Raudsepp, Terje; Pearks Wilkerson, Alison J; Agarwala, Richa; Schffer, Alejandro A; Houck, Marlys; Chowdhary, Bhanu P; Murphy, William J

    2009-04-01

    We describe the construction of a high-resolution radiation hybrid (RH) map of the domestic cat genome, which includes 2662 markers, translating to an estimated average intermarker distance of 939 kilobases (kb). Targeted marker selection utilized the recent feline 1.9x genome assembly, concentrating on regions of low marker density on feline autosomes and the X chromosome, in addition to regions flanking interspecies chromosomal breakpoints. Average gap (breakpoint) size between cat-human ordered conserved segments is less than 900 kb. The map was used for a fine-scale comparison of conserved syntenic blocks with the human and canine genomes. Corroborative fluorescence in situ hybridization (FISH) data were generated using 129 domestic cat BAC clones as probes, providing independent confirmation of the long-range correctness of the map. Cross-species hybridization of BAC probes on divergent felids from the genera Profelis (serval) and Panthera (snow leopard) provides further evidence for karyotypic conservation within felids, and demonstrates the utility of such probes for future studies of chromosome evolution within the cat family and in related carnivores. The integrated map constitutes a comprehensive framework for identifying genes controlling feline phenotypes of interest, and to aid in assembly of a higher coverage feline genome sequence. PMID:18951970

  20. Embodied energy of construction materials: integrating human and capital energy into an IO-based hybrid model.

    PubMed

    Dixit, Manish K; Culp, Charles H; Fernandez-Solis, Jose L

    2015-02-01

    Buildings alone consume approximately 40% of the annual global energy and contribute indirectly to the increasing concentration of atmospheric carbon. The total life cycle energy use of a building is composed of embodied and operating energy. Embodied energy includes all energy required to manufacture and transport building materials, and construct, maintain, and demolish a building. For a systemic energy and carbon assessment of buildings, it is critical to use a whole life cycle approach, which takes into account the embodied as well as operating energy. Whereas the calculation of a building's operating energy is straightforward, there is a lack of a complete embodied energy calculation method. Although an input-output-based (IO-based) hybrid method could provide a complete and consistent embodied energy calculation, there are unresolved issues, such as an overdependence on price data and exclusion of the energy of human labor and capital inputs. This paper proposes a method for calculating and integrating the energy of labor and capital input into an IO-based hybrid method. The results demonstrate that the IO-based hybrid method can provide relatively complete results. Also, to avoid errors, the total amount of human and capital energy should not be excluded from the calculation. PMID:25561008

  1. Hierarchy of hybrid unsteady-flow simulations integrating time-resolved PTV with DNS and their data-assimilation capabilities

    NASA Astrophysics Data System (ADS)

    Suzuki, Takao; Yamamoto, Fujio

    2015-10-01

    Data-assimilation capabilities of hybrid-type simulations integrating time-resolved particle image velocimetry with unsteady computational fluid dynamics (CFD) are characterized, and a series of algorithms developed previously are evaluated in terms of four criteria: (i) compatibility with the governing equations; (ii) completeness of a set of flow quantities; (iii) temporal and spatial filtering functions; and (iv) spatial resolution. This study specifically introduces a hierarchy of three hybrid simulations combining time-resolved particle tracking velocimetry (PTV) and direct numerical simulation (DNS) from low to high fidelities: the proper orthogonal decomposition-Galerkin-projection approach with proportional feedback of PTV data, the DNS solver with similar feedback, and the DNS solver with the extended Kalman filter. By solving a planar-jet problem at {Re}≈ 2000, we demonstrate that the resultant hybrid flow fields essentially (i) satisfy the governing equations spatially and approximately temporally, and (ii) can provide instantaneous pressure fields (iii) with the noise levels substantially lower than those of the original PTV data and (iv) the resolution comparable to CFD. The results show that increasing the feedback gain improves replicability, i.e. the agreement between the simulation and the data; however, it degrades temporal compatibility and filtering functions. On the other hand, the fidelity enhances both replicability and spatial filtering, but increases computational cost.

  2. INTEGRATION OF GENETIC AND RADIATION HYBRID MAPS OF THE PIG: THE SECOND GENERATION IMPRH MAPS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    More than 4500 markers, ESTs and genes have been mapped on IMpRH radiation hybrid panel and submitted to IMpRH Server before 30 March 2002, whereas 757 markers only were mapped on the first generation map (Hawken et al, 1999). To take advantage of the different resolutions observed on the genetic an...

  3. Hybrid MCDA Methods to Integrate Multiple Ecosystem Services in Forest Management Planning: A Critical Review.

    PubMed

    Uhde, Britta; Hahn, W Andreas; Griess, Verena C; Knoke, Thomas

    2015-08-01

    Multi-criteria decision analysis (MCDA) is a decision aid frequently used in the field of forest management planning. It includes the evaluation of multiple criteria such as the production of timber and non-timber forest products and tangible as well as intangible values of ecosystem services (ES). Hence, it is beneficial compared to those methods that take a purely financial perspective. Accordingly, MCDA methods are increasingly popular in the wide field of sustainability assessment. Hybrid approaches allow aggregating MCDA and, potentially, other decision-making techniques to make use of their individual benefits and leading to a more holistic view of the actual consequences that come with certain decisions. This review is providing a comprehensive overview of hybrid approaches that are used in forest management planning. Today, the scientific world is facing increasing challenges regarding the evaluation of ES and the trade-offs between them, for example between provisioning and regulating services. As the preferences of multiple stakeholders are essential to improve the decision process in multi-purpose forestry, participatory and hybrid approaches turn out to be of particular importance. Accordingly, hybrid methods show great potential for becoming most relevant in future decision making. Based on the review presented here, the development of models for the use in planning processes should focus on participatory modeling and the consideration of uncertainty regarding available information. PMID:25896820

  4. Hybrid MCDA Methods to Integrate Multiple Ecosystem Services in Forest Management Planning: A Critical Review

    NASA Astrophysics Data System (ADS)

    Uhde, Britta; Andreas Hahn, W.; Griess, Verena C.; Knoke, Thomas

    2015-08-01

    Multi-criteria decision analysis (MCDA) is a decision aid frequently used in the field of forest management planning. It includes the evaluation of multiple criteria such as the production of timber and non-timber forest products and tangible as well as intangible values of ecosystem services (ES). Hence, it is beneficial compared to those methods that take a purely financial perspective. Accordingly, MCDA methods are increasingly popular in the wide field of sustainability assessment. Hybrid approaches allow aggregating MCDA and, potentially, other decision-making techniques to make use of their individual benefits and leading to a more holistic view of the actual consequences that come with certain decisions. This review is providing a comprehensive overview of hybrid approaches that are used in forest management planning. Today, the scientific world is facing increasing challenges regarding the evaluation of ES and the trade-offs between them, for example between provisioning and regulating services. As the preferences of multiple stakeholders are essential to improve the decision process in multi-purpose forestry, participatory and hybrid approaches turn out to be of particular importance. Accordingly, hybrid methods show great potential for becoming most relevant in future decision making. Based on the review presented here, the development of models for the use in planning processes should focus on participatory modeling and the consideration of uncertainty regarding available information.

  5. Are hybrid models integrated with data preprocessing techniques suitable for monthly streamflow forecasting? Some experiment evidences

    NASA Astrophysics Data System (ADS)

    Zhang, Xiaoli; Peng, Yong; Zhang, Chi; Wang, Bende

    2015-11-01

    A number of hydrological studies have proven the superior prediction performance of hybrid models coupled with data preprocessing techniques. However, many studies first decompose the entire data series into components and later divide each component into calibration and validation datasets to establish models, which sends some amount of future information into the decomposition and reconstruction processes. As a consequence, the resulting components used to forecast the value of a particular moment are computed using information from future values, which are not available at that particular moment in a forecasting exercise. Since most papers don't present their model framework in detail, it is difficult to identify whether they are performing a real forecast or not. Even though several other papers have explicitly stated which experiment they are performing, a comparison between results in the hindcast and forecast experiments is still missing. Therefore, it is necessary to investigate and compare the performance of these hybrid models in the two experiments in order to estimate whether they are suitable for real forecasting. With the combination of three preprocessing techniques, such as wavelet analysis (WA), empirical mode decomposition (EMD) and singular spectrum analysis (SSA), and two modeling methods (i.e. ANN model and ARMA model), six hybrid models are developed in this study, including WA-ANN, WA-ARMA, EMD-ANN, EMD-ARMA, SSA-ANN and SSA-ARMA. Preprocessing techniques are used to decompose the data series into sub-series, and then these sub-series are modeled using ANN and ARMA models. These models are examined in hindcasting and forecasting of the monthly streamflow of two sites in the Yangtze River of China. The results of this study indicate that the six hybrid models perform better in the hindcast experiment compared with the original ANN and ARMA models, while the hybrid models in the forecast experiment perform worse than the original models and the performances of WA-based and EMD-based models vary largely across different extension methods. It can be concluded that the hybrid models are not suitable for monthly streamflow forecasting in this study. New extension methods and modified preprocessing techniques can improve the prediction performance of these hybrid models in forecast experiments.

  6. 12.5 pm/V hybrid silicon and lithium niobate optical microring resonator with integrated electrodes.

    PubMed

    Chen, Li; Wood, Michael G; Reano, Ronald M

    2013-11-01

    We present a silicon microring resonator with a lithium niobate top cladding and integrated tuning electrodes. Submicrometer thin films of z-cut lithium niobate are bonded to silicon microring resonators via benzocyclobutene. Integrated electrodes are incorporated to confine voltage controlled electric fields within the lithium niobate thin film. The electrode design utilizes thin film metal electrodes and an optically transparent electrode wherein the silicon waveguide core serves as both an optical waveguide medium and as a conductive electrode medium. The hybrid material system combines the electro-optic functionality of lithium niobate with the high index contrast of silicon waveguides, enabling compact low tuning voltage microring resonators. Optical characterization of fabricated devices results in a measured loaded quality factor of 11,500 and a free spectral range of 7.15 nm in the infrared. The demonstrated tunability is 12.5 pm/V, which is over an order of magnitude greater than electrode-free designs. PMID:24216923

  7. Integrated Solid/Nanoporous Copper/Oxide Hybrid Bulk Electrodes for High-performance Lithium-Ion Batteries

    PubMed Central

    Hou, Chao; Lang, Xing-You; Han, Gao-Feng; Li, Ying-Qi; Zhao, Lei; Wen, Zi; Zhu, Yong-Fu; Zhao, Ming; Li, Jian-Chen; Lian, Jian-She; Jiang, Qing

    2013-01-01

    Nanoarchitectured electroactive materials can boost rates of Li insertion/extraction, showing genuine potential to increase power output of Li-ion batteries. However, electrodes assembled with low-dimensional nanostructured transition metal oxides by conventional approach suffer from dramatic reductions in energy capacities owing to sluggish ion and electron transport kinetics. Here we report that flexible bulk electrodes, made of three-dimensional bicontinuous nanoporous Cu/MnO2 hybrid and seamlessly integrated with Cu solid current collector, substantially optimizes Li storage behavior of the constituent MnO2. As a result of the unique integration of solid/nanoporous hybrid architecture that simultaneously enhances the electron transport of MnO2, facilitates fast ion diffusion and accommodates large volume changes on Li insertion/extraction of MnO2, the supported MnO2 exhibits a stable capacity of as high as ~1100 mA h g−1 for 1000 cycles, and ultrahigh charge/discharge rates. It makes the environmentally friendly and low-cost electrode as a promising anode for high-performance Li-ion battery applications. PMID:24096928

  8. Hybrid calculation of electron--polar-molecule scattering: Integrated andmomentum-transfer cross sections for LiF

    SciTech Connect

    Siegel, J.; Dehmer, J.L.; Dill, D.

    1981-02-01

    We describe in detail a hybrid method for calculation of electron--polar-molecule scattering in which (1) low-l S-matrix elements are calculated in the body frame using a potential which incorporates a realistic representation of the molecular core; (2) intermediate-l elements are calculated in the body frame using an exact method with a point-dipole potential; and (3) high-l elements are calculated in the laboratory frame using the first Born approximation with a point-dipole potential. By taking into account the dominant interactions of each l range when choosing the coordinate frame, potential, and calculational method, this hybrid framework achieves an exceptionally high level of efficiency and economy of calculation without sacrifice of accuracy. Using this method, we have calculated integrated and momentum-transfer cross sections for e-LiF scattering from 1 to 20 eV (differential cross sections have been reported elsewhere). The integrated cross section is dominated (>99%) by the j=0..-->..j'=1 rotational transition, whereas the momentum-transfer cross section is composed of comparable contributions from transitions to final j'=0 through 3, owing to its deemphasis of small-angle scattering. Eigenphase sums show no sign of resonant activity in this energy range.

  9. Large-scale complementary macroelectronics using hybrid integration of carbon nanotubes and IGZO thin-film transistors

    NASA Astrophysics Data System (ADS)

    Chen, Haitian; Cao, Yu; Zhang, Jialu; Zhou, Chongwu

    2014-06-01

    Carbon nanotubes and metal oxide semiconductors have emerged as important materials for p-type and n-type thin-film transistors, respectively; however, realizing sophisticated macroelectronics operating in complementary mode has been challenging due to the difficulty in making n-type carbon nanotube transistors and p-type metal oxide transistors. Here we report a hybrid integration of p-type carbon nanotube and n-type indium-gallium-zinc-oxide thin-film transistors to achieve large-scale (>1,000 transistors for 501-stage ring oscillators) complementary macroelectronic circuits on both rigid and flexible substrates. This approach of hybrid integration allows us to combine the strength of p-type carbon nanotube and n-type indium-gallium-zinc-oxide thin-film transistors, and offers high device yield and low device variation. Based on this approach, we report the successful demonstration of various logic gates (inverter, NAND and NOR gates), ring oscillators (from 51 stages to 501 stages) and dynamic logic circuits (dynamic inverter, NAND and NOR gates).

  10. Precision measurement of the top quark mass in the lepton + jets channel using a matrix element method with Quasi-Monte Carlo integration

    SciTech Connect

    Lujan, Paul Joseph; /UC, Berkeley /LBL, Berkeley

    2009-12-01

    This thesis presents a measurement of the top quark mass obtained from p{bar p} collisions at {radical}s = 1.96 TeV at the Fermilab Tevatron using the CDF II detector. The measurement uses a matrix element integration method to calculate a t{bar t} likelihood, employing a Quasi-Monte Carlo integration, which enables us to take into account effects due to finite detector angular resolution and quark mass effects. We calculate a t{bar t} likelihood as a 2-D function of the top pole mass m{sub t} and {Delta}{sub JES}, where {Delta}{sub JES} parameterizes the uncertainty in our knowledge of the jet energy scale; it is a shift applied to all jet energies in units of the jet-dependent systematic error. By introducing {Delta}{sub JES} into the likelihood, we can use the information contained in W boson decays to constrain {Delta}{sub JES} and reduce error due to this uncertainty. We use a neural network discriminant to identify events likely to be background, and apply a cut on the peak value of individual event likelihoods to reduce the effect of badly reconstructed events. This measurement uses a total of 4.3 fb{sup -1} of integrated luminosity, requiring events with a lepton, large E{sub T}, and exactly four high-energy jets in the pseudorapidity range |{eta}| < 2.0, of which at least one must be tagged as coming from a b quark. In total, we observe 738 events before and 630 events after applying the likelihood cut, and measure m{sub t} = 172.6 {+-} 0.9 (stat.) {+-} 0.7 (JES) {+-} 1.1 (syst.) GeV/c{sup 2}, or m{sub t} = 172.6 {+-} 1.6 (tot.) GeV/c{sup 2}.

  11. A practical hybrid model of application, integration, and competencies at interactive table conferences in histology (ITCH).

    PubMed

    Ettarh, Rajunor

    2016-05-01

    Significant changes have been implemented in the way undergraduate medical education is structured. One of the challenges for component courses such as histology in medical and dental curricula is to restructure and deliver training within new frameworks. This article describes the process of aligning the purpose and experience in histology laboratory to the goal of applying knowledge gained to team-based medical practice at Tulane University School of Medicine. Between 2011 and 2015, 711 medical students took either a traditional laboratory-based histology course (353 students) or a team-based hybrid histology course with active learning in laboratory (358 students). The key difference was in the laboratory component of the hybrid course - interactive table conferences in histology-during which students developed new competencies by working in teams, reviewing images, solving problems by applying histology concepts, and sharing learning. Content, faculty and online resources for microscopy were the same in both courses. More student-student and student-faculty interactions were evident during the hybrid course but student evaluation ratings and grades showed reductions following introduction of table conferences when compared to previous ratings. However, outcomes at National Board of Medical Examiners(®) (NBME(®) ) Subject Examination in Histology and Cell Biology showed significant improvement (72.4 ± 9.04 and 76.44 ± 9.36 for percent correct answers, traditional and hybrid courses, respectively, P < 0.0001). This model of table conferences to augment the traditional histology laboratory experience exemplifies the extent that restructuring enhancements can be used in currently taught courses in the undergraduate medical curriculum. Anat Sci Educ 9: 286-294. © 2016 American Association of Anatomists. PMID:26749245

  12. Fluorescent In Situ Hybridization to Detect Transgene Integration into Plant Genomes

    NASA Astrophysics Data System (ADS)

    Schwarzacher, Trude

    Fluorescent chromosome analysis technologies have advanced our understanding of genome organization during the last 30 years and have enabled the investigation of DNA organization and structure as well as the evolution of chromosomes. Fluorescent chromosome staining allows even small chromosomes to be visualized, characterized by their composition and morphology, and counted. Aneuploidies and polyploidies can be established for species, breeding lines, and individuals, including changes occurring during hybridization or tissue culture and transformation protocols. Fluorescent in situ hybridization correlates molecular information of a DNA sequence with its physical location on chromosomes and genomes. It thus allows determination of the physical position of sequences and often is the only means to determine the abundance and distribution of DNA sequences that are difficult to map with any other molecular method or would require segregation analysis, in particular multicopy or repetitive DNA. Equally, it is often the best way to establish the incorporation of transgenes, their numbers, and physical organization along chromosomes. This chapter presents protocols for probe and chromosome preparation, fluorescent in situ hybridization, chromosome staining, and the analysis of results.

  13. Method for producing a hybridization of detector array and integrated circuit for readout

    NASA Technical Reports Server (NTRS)

    Fossum, Eric R. (Inventor); Grunthaner, Frank J. (Inventor)

    1993-01-01

    A process is explained for fabricating a detector array in a layer of semiconductor material on one substrate and an integrated readout circuit in a layer of semiconductor material on a separate substrate in order to select semiconductor material for optimum performance of each structure, such as GaAs for the detector array and Si for the integrated readout circuit. The detector array layer is lifted off its substrate, laminated on the metallized surface on the integrated surface, etched with reticulating channels to the surface of the integrated circuit, and provided with interconnections between the detector array pixels and the integrated readout circuit through the channels. The adhesive material for the lamination is selected to be chemically stable to provide electrical and thermal insulation and to provide stress release between the two structures fabricated in semiconductor materials that may have different coefficients of thermal expansion.

  14. Monte Carlo simulation of the dose response of a novel 2D silicon diode array for use in hybrid MRI–LINAC systems

    SciTech Connect

    Gargett, Maegan Rosenfeld, Anatoly; Oborn, Brad; Metcalfe, Peter

    2015-02-15

    Purpose: MRI-guided radiation therapy systems (MRIgRT) are being developed to improve online imaging during treatment delivery. At present, the operation of single point dosimeters and an ionization chamber array have been characterized in such systems. This work investigates a novel 2D diode array, named “magic plate,” for both single point calibration and 2D positional performance, the latter being a key element of modern radiotherapy techniques that will be delivered by these systems. Methods: GEANT4 Monte Carlo methods have been employed to study the dose response of a silicon diode array to 6 MV photon beams, in the presence of in-line and perpendicularly aligned uniform magnetic fields. The array consists of 121 silicon diodes (dimensions 1.5 × 1.5 × 0.38 mm{sup 3}) embedded in kapton substrate with 1 cm pitch, spanning a 10 × 10 cm{sup 2} area in total. A geometrically identical, water equivalent volume was simulated concurrently for comparison. The dose response of the silicon diode array was assessed for various photon beam field shapes and sizes, including an IMRT field, at 1 T. The dose response was further investigated at larger magnetic field strengths (1.5 and 3 T) for a 4 × 4 cm{sup 2} photon field size. Results: The magic plate diode array shows excellent correspondence (< ± 1%) to water dose in the in-line orientation, for all beam arrangements and magnetic field strengths investigated. The perpendicular orientation, however, exhibits a dose shift with respect to water at the high-dose-gradient beam edge of jaw-defined fields [maximum (4.3 ± 0.8)% over-response, maximum (1.8 ± 0.8)% under-response on opposing side for 1 T, uncertainty 1σ]. The trend is not evident in areas with in-field dose gradients typical of IMRT dose maps. Conclusions: A novel 121 pixel silicon diode array detector has been characterized by Monte Carlo simulation for its performance inside magnetic fields representative of current prototype and proposed MRI–linear accelerator systems. In the in-line orientation, the silicon dose is directly proportional to the water dose. In the perpendicular orientation, there is a shift in dose response relative to water in the highest dose gradient regions, at the edge of jaw-defined and single-segment MLC fields. The trend was not observed in-field for an IMRT beam. The array is expected to be a valuable tool in MRIgRT dosimetry.

  15. Electronic integration of fuel cell and battery system in novel hybrid vehicle

    NASA Astrophysics Data System (ADS)

    Fisher, Peter; Jostins, John; Hilmansen, Stuart; Kendall, Kevin

    2012-12-01

    The objective of this work was to integrate a lithium ion battery pack, together with its management system, into a hydrogen fuel cell drive train contained in a lightweight city car. Electronic units were designed to link the drive train components using conventional circuitry. These were built, tested and shown to perform according to the design. These circuits allowed start-up of battery management system, motor controller, fuel cell warm-up and torque monitoring. After assembling the fuel cell and battery in the vehicle, full system tests were performed. Analysis of results from vehicle demonstrations showed operation was satisfactory. The conclusion was that the electronic integration was successful, but the design needed optimisation and fine tuning. Eight vehicles were then fitted with the electronically integrated fuel cell-battery power pack. Trials were then started to test the integration more fully, with a duration of 12 months from 2011 to 2012 in the CABLED project.

  16. An efficient hybrid MLFMA FFT solver for the volume integral equation in case of sparse 3D inhomogeneous dielectric scatterers

    NASA Astrophysics Data System (ADS)

    De Zaeytijd, J.; Bogaert, I.; Franchois, A.

    2008-07-01

    Electromagnetic scattering problems involving inhomogeneous objects can be numerically solved by applying a Method of Moments discretization to the volume integral equation. For electrically large problems, the iterative solution of the resulting linear system is expensive, both computationally and in memory use. In this paper, a hybrid MLFMA-FFT method is presented, which combines the fast Fourier transform (FFT) method and the High Frequency Multilevel Fast Multipole Algorithm (MLFMA) in order to reduce the cost of the matrix-vector multiplications needed in the iterative solver. The method represents the scatterers within a set of possibly disjoint identical cubic subdomains, which are meshed using a uniform cubic grid. This specific mesh allows for the application of FFTs to calculate the near interactions in the MLFMA and reduces the memory cost considerably, since the aggregation and disaggregation matrices of the MLFMA can be reused. Additional improvements to the general MLFMA framework, such as an extention of the FFT interpolation scheme of Sarvas et al. from the scalar to the vectorial case in combination with a more economical representation of the radiation patterns on the lowest level in vector spherical harmonics, are proposed and the choice of the subdomain size is discussed. The hybrid method performs better in terms of speed and memory use on large sparse configurations than both the FFT method and the HF MLFMA separately and it has lower memory requirements on general large problems. This is illustrated on a number of representative numerical test cases.

  17. Spectral CT modeling and reconstruction with hybrid detectors in dynamic-threshold-based counting and integrating modes.

    PubMed

    Li, Liang; Chen, Zhiqiang; Cong, Wenxiang; Wang, Ge

    2015-03-01

    Spectral CT with photon counting detectors can significantly improve CT performance by reducing image noise and dose, increasing contrast resolution and material specificity, as well as enabling functional and molecular imaging with existing and emerging probes. However, the current photon counting detector architecture is difficult to balance the number of energy bins and the statistical noise in each energy bin. Moreover, the hardware support for multi-energy bins demands a complex circuit which is expensive. In this paper, we promote a new scheme known as hybrid detectors that combine the dynamic-threshold-based counting and integrating modes. In this scheme, an energy threshold can be dynamically changed during a spectral CT scan, which can be considered as compressive sensing along the spectral dimension. By doing so, the number of energy bins can be retrospectively specified, even in a spatially varying fashion. To establish the feasibility and merits of such hybrid detectors, we develop a tensor-based PRISM algorithm to reconstruct a spectral CT image from dynamic dual-energy data, and perform experiments with simulated and real data, producing very promising results. PMID:25252279

  18. New integration scheme of GPS-INS hybrid navigation system for maneuvering spacecraft

    NASA Astrophysics Data System (ADS)

    Tanabe, T.; Harigae, M.; Koyama, H.

    Integration schemes of the GPS with INS are considered. In the conventional navigation scheme, information from INS is usually used in the form of velocity-aiding signal to the receiver-tracking loops. In this paper, a new integration scheme is proposed which performs more effective information exchange so that it is more tolerant to RF interferences and unmodeled INS errors than the conventional scheme. These results are obtained from theoretical analyses and confirmed by computer simulations including GPS receiver dynamics.

  19. A nanoelectronic nose: a hybrid nanowire/carbon nanotube sensor array with integrated micromachined hotplates for sensitive gas discrimination

    NASA Astrophysics Data System (ADS)

    Chen, Po-Chiang; Ishikawa, Fumiaki N.; Chang, Hsiao-Kang; Ryu, Koungmin; Zhou, Chongwu

    2009-03-01

    A novel hybrid chemical sensor array composed of individual In2O3 nanowires, SnO2 nanowires, ZnO nanowires, and single-walled carbon nanotubes with integrated micromachined hotplates for sensitive gas discrimination was demonstrated. Key features of our approach include the integration of nanowire and carbon nanotube sensors, precise control of the sensor temperature using the micromachined hotplates, and the use of principal component analysis for pattern recognition. This sensor array was exposed to important industrial gases such as hydrogen, ethanol and nitrogen dioxide at different concentrations and sensing temperatures, and an excellent selectivity was obtained to build up an interesting 'smell-print' library of these gases. Principal component analysis of the sensing results showed great discrimination of those three tested chemicals, and in-depth analysis revealed clear improvement of selectivity by the integration of carbon nanotube sensors. This nanoelectronic nose approach has great potential for detecting and discriminating between a wide variety of gases, including explosive ones and nerve agents.

  20. A nanoelectronic nose: a hybrid nanowire/carbon nanotube sensor array with integrated micromachined hotplates for sensitive gas discrimination.

    PubMed

    Chen, Po-Chiang; Ishikawa, Fumiaki N; Chang, Hsiao-Kang; Ryu, Koungmin; Zhou, Chongwu

    2009-03-25

    A novel hybrid chemical sensor array composed of individual In(2)O(3) nanowires, SnO(2) nanowires, ZnO nanowires, and single-walled carbon nanotubes with integrated micromachined hotplates for sensitive gas discrimination was demonstrated. Key features of our approach include the integration of nanowire and carbon nanotube sensors, precise control of the sensor temperature using the micromachined hotplates, and the use of principal component analysis for pattern recognition. This sensor array was exposed to important industrial gases such as hydrogen, ethanol and nitrogen dioxide at different concentrations and sensing temperatures, and an excellent selectivity was obtained to build up an interesting 'smell-print' library of these gases. Principal component analysis of the sensing results showed great discrimination of those three tested chemicals, and in-depth analysis revealed clear improvement of selectivity by the integration of carbon nanotube sensors. This nanoelectronic nose approach has great potential for detecting and discriminating between a wide variety of gases, including explosive ones and nerve agents. PMID:19420469

  1. Ship-in-a-bottle integration by hybrid femtosecond laser technology for fabrication of true 3D biochips

    NASA Astrophysics Data System (ADS)

    Sima, Felix; Wu, Dong; Xu, Jian; Midorikawa, Katsumi; Sugioka, Koji

    2015-03-01

    We propose herein the "ship-in-a-bottle" integration of three-dimensional (3D) polymeric sinusoidal ridges inside photosensitive glass microfluidic channel by a hybrid subtractive - additive femtosecond laser processing method. It consists of Femtosecond Laser Assisted Wet Etching (FLAE) of a photosensitive Foturan glass followed by Two-Photon Polymerization (TPP) of a SU-8 negative epoxy-resin. Both subtractive and additive processes are carried out using the same set-up with the change of laser focusing objective only. A 522 nm wavelength of the second harmonic generation from an amplified femtosecond Yb-fiber laser (FCPA µJewel D-400, IMRA America, 1045 nm; pulse width 360 fs, repetition rate 200 kHz) was employed for irradiation. The new method allows lowering the size limit of 3D objects created inside channels to smaller details down to the dimensions of a cell, and improve the structure stability. Sinusoidal periodic patterns and ridges are of great use as base scaffolds for building up new structures on their top or for modulating cell migration, guidance and orientation while created interspaces can be exploited for microfluidic applications. The glass microchannel offers robustness and appropriate dynamic flow conditions for cellular studies while the integrated patterns are reducing the size of structure to the level of cells responsiveness. Taking advantage of the ability to directly fabricate 3D complex shapes, both glass channels and polymeric integrated patterns enable us to 3D spatially design biochips for specific applications.

  2. Measuring volatility persistence on rainfall records with the hybrid of autoregressive fractional integrated moving average (ARFIMA) - hidden Markov model (HMM)

    NASA Astrophysics Data System (ADS)

    Yusof, Fadhilah; Kane, Ibrahim Lawal; Yusop, Zulkifli

    2015-02-01

    Precarious circumstances related to rainfall events can be due to very intense or persistence of rainfall over a long period of time. Such events may give rise to an exceedence of the capacity of sewer systems resulting to landslides or flooding. One of the conventional ways of measuring such risk associated with persistence in rain is done through studies of long term persistence and volatility persistence. This work investigates the persistence level of Kuantan daily rainfall using the hybrid of autoregressive fractional integrated moving average (ARFIMA) and hidden Markov model (HMM). The result shows that the rainfall variability period returns quickly to its usual variability level which may not have a lasting period of extreme wet, hence relatively stable rainfall behavior is observed in Kuantan rainfall. This will enhance the understanding of the process for the successful development and implementation of water resource tools to assess engineering and environmental problems such as flood control.

  3. Improving integration of high-Q silicon nitride membrane resonators into electro-opto-mechanical devices for hybrid quantum systems

    NASA Astrophysics Data System (ADS)

    Cicak, K.; Andrews, R. W.; Yu, P.-L.; Peterson, R. W.; Purdy, T. P.; Burns, P. S.; Regal, C. A.; Lehnert, K. W.; Simmonds, R. W.

    2015-03-01

    Macroscopic high-stress silicon nitride membranes can be implemented as ultra-high-quality-factor mechanical resonators operating in the quantum regime with average phonon occupancy below one quantum. Mechanical motion of these resonators can be engineered to simultaneously couple both to (THz) light in free-space optical cavities and to microwave (GHz) fields in superconducting circuits. Exploiting this parametric coupling to realize quantum information transfer between these domains entails construction of devices with challenging requirements. These devices must integrate the membranes with superconducting circuits operating at cryogenic temperatures in proximity of free space optical photons while meeting demands for various quantum and coupling requirements. Here we show how to construct such ``hybrid quantum devices'' by microfabricating and assembling chip-based structures that can be inserted into high-finesse optical cavities compatible with low temperatures. We include an overview of recent fabrication improvements of membranes mechanically isolated from environment by phononic band-gap crystals.

  4. Test of Integrated Professional Skills: Objective Structured Clinical Examination/Simulation Hybrid Assessment of Obstetrics-Gynecology Residents' Skill Integration

    PubMed Central

    Winkel, Abigail Ford; Gillespie, Colleen; Hiruma, Marissa T.; Goepfert, Alice R.; Zabar, Sondra; Szyld, Demian

    2014-01-01

    Background Assessment of obstetrics-gynecology residents' ability to integrate clinical judgment, interpersonal skills, and technical ability in a uniform fashion is required to document achievement of benchmarks of competency. An observed structured clinical examination that incorporates simulation and bench models uses direct observation of performance to generate formative feedback and standardized evaluation. Methods The Test of Integrated Professional Skills (TIPS) is a 5-station performance-based assessment that uses standardized patients and complex scenarios involving ultrasonography, procedural skills, and evidence-based medicine. Standardized patients and faculty rated residents by using behaviorally anchored checklists. Mean scores reflecting performance in TIPS were compared across competency domains and by developmental level (using analysis of variance) and then compared to standard faculty clinical evaluations (using Spearman ρ). Participating faculty and residents were also asked to evaluate the usefulness of the TIPS. Results Twenty-four residents participated in the TIPS. Checklist items used to assess competency were sufficiently reliable, with Cronbach α estimates from 0.69 to 0.82. Performance improved with level of training, with wide variation in performance. Standard faculty evaluations did not correlate with TIPS performance. Several residents who were rated as average or above average by faculty performed poorly on the TIPS (> 1 SD below the mean). Both faculty and residents found the TIPS format useful, providing meaningful evaluation and opportunity for feedback. Conclusions A simulation-based observed structured clinical examination facilitates observation of a range of skills, including competencies that are difficult to observe and measure in a standardized way. Debriefing with faculty provides an important interface for identification of performance gaps and individualization of learning plans. PMID:24701321

  5. Using a hybrid Monte Carlo/ Slip Estimator-Genetic Algorithm (MCSE-GA) to produce high resolution estimates of paleoearthquakes from geodetic data

    NASA Astrophysics Data System (ADS)

    Lindsay, Anthony; McCloskey, John; Simão, Nuno; Murphy, Shane; Bhloscaidh, Mairead Nic

    2014-05-01

    Identifying fault sections where slip deficits have accumulated may provide a means for understanding sequences of large megathrust earthquakes. Stress accumulated during the interseismic period on an active megathrust is stored as potential slip, referred to as slip deficit, along locked sections of the fault. Analysis of the spatial distribution of slip during antecedent events along the fault will show where the locked plate has spent its stored slip. Areas of unreleased slip indicate where the potential for large events remain. The location of recent earthquakes and their distribution of slip can be estimated from instrumentally recorded seismic and geodetic data. However, long-term slip-deficit modelling requires detailed information on the size and distribution of slip for pre-instrumental events over hundreds of years covering more than one 'seismic cycle'. This requires the exploitation of proxy sources of data. Coral microatolls, growing in the intertidal zone of the outer island arc of the Sunda trench, present the possibility of reconstructing slip for a number of pre-instrumental earthquakes. Their growth is influenced by tectonic flexing of the continental plate beneath them; they act as long term recorders of the vertical component of deformation. However, the sparse distribution of data available using coral geodesy results in a under determined problem with non-unique solutions. Rather than accepting any one realisation as the definite model satisfying the coral displacement data, a Monte Carlo approach identifies a suite of models consistent with the observations. Using a Genetic Algorithm to accelerate the identification of desirable models, we have developed a Monte Carlo Slip Estimator- Genetic Algorithm (MCSE-GA) which exploits the full range of uncertainty associated with the displacements. Each iteration of the MCSE-GA samples different values from within the spread of uncertainties associated with each coral displacement. The Genetic Algorithm element of the MCSE-GA allows it to recombine the information stored in a population of randomly generated models to rapidly converge on a possible solution. These solutions are evaluated and those satisfying a threshold number of observations join an ensemble of models contributing to a final Weighted Average Model (WAM). The WAM represents a high resolution estimate of the slip distribution responsible for any given set of displacements. Analysis of the slip values of the ensemble models allows areas of high confidence to be identified where the standard deviation is low. Similarly, areas of low confidence will be found where standard deviations are high. This presentation will demonstrate the ability of the MCSE-GA to produce both accurate models of slip for a number of recent instrumentally recorded earthquakes along the Sunda Trench and estimates of slip during 1797 and 1833 paleoearthquakes that are consistent with those produced from other techniques.

  6. Integration of Ecogpt and SV40 early region sequences into human chromosome 17: a dominant selection system in whole cell and microcell human-mouse hybrids.

    PubMed Central

    Tunnacliffe, A; Parkar, M; Povey, S; Bengtsson, B O; Stanley, K; Solomon, E; Goodfellow, P

    1983-01-01

    The dominant selectable gene, Ecogpt, has been introduced, by the calcium phosphate precipitation technique, into normal human fibroblasts, along with the SV40 early region genes. In one transfectant clone, integration of these sequences into human chromosome 17 was demonstrated by the construction of human-mouse somatic cell hybrids, selected for by growth in medium containing mycophenolic acid and xanthine. A whole cell hybrid, made between the human transfectant and a mouse L cell, was used as donor of the Ecogpt-carrying human chromosome 17 to 'tribrids' growing in suspension, made by whole cell fusion between a mouse thymoma cell line, and to microcell hybrids made with a mouse teratocarcinoma cell line. Two tribrids contained karyotypically normal human chromosomes 17 and a small number of other human chromosomes, while a third tribrid had a portion of the long arm of chromosome 17 translocated to mouse as its only human genetic material. Two independent microcell hybrids contained a normal chromosome 17 and no other human chromosome on a mouse teratocarcinoma background. These experiments demonstrate the ability to construct human-mouse somatic cell hybrids using a dominant selection system. By applying this approach it should be possible to select for a wide range of different human chromosomes in whole cell and microcell hybrids. In particular, transfer of single human chromosomes to mouse teratocarcinoma cells will allow examination of developmentally regulated human gene sequences after differentiation of such hybrids. Images Fig. 1. Fig. 2. Fig. 3. Fig. 4. Fig. 5. Fig. 6. Fig. 7. PMID:11892815

  7. Excitation functions of heavy residues produced in the 14N+103Rh reaction up to 400 MeV: Analysis of the pre-equilibrium mechanism with the hybrid Monte Carlo simulation model

    NASA Astrophysics Data System (ADS)

    Acharya, J.; Mukherjee, S.; Steyn, G. F.; Singh, N. L.; Chatterjee, A.

    2016-02-01

    The excitation functions of heavy residues, produced in the interaction of 14N with 103Rh, have been measured over the projectile energy region from a threshold up to 400 MeV by means of the activation method in conjunction with γ-ray spectroscopy. Cross sections for 15 reaction residues are presented, namely, 104Cd, Ag-105103, Pd-10199, 97,99,101Rh, Ru,9795, and Tc-9694. The experimental data are compared with theoretical model predictions using the hybrid Monte Carlo simulation model as implemented in the recently released alice2014 code. The theory assumes that the dominant pre-equilibrium mechanism includes multinucleon and cluster emissions in the initial stages of the interaction between the projectile and the target nucleus. Overall, the theoretical predictions provide a satisfactory agreement with the trend of the present experimental results for most of the observed reaction residues. This provides strong evidence that the underlying reaction mechanisms in the code are appropriately described. Overall, the Obninsk level densities give the best results in the present study.

  8. Imidazo[1,2-a]pyrazine inhibitors of phosphoinositide 3-kinase alpha (PI3K?): 3D-QSAR analysis utilizing the Hybrid Monte Carlo algorithm to refine receptor-ligand complexes for molecular alignment.

    PubMed

    Chadha, N; Jasuja, H; Kaur, M; Singh Bahia, M; Silakari, O

    2014-01-01

    Phosphoinositide 3-kinase alpha (PI3K?) is a lipid kinase involved in several cellular functions such as cell growth, proliferation, differentiation and survival, and its anomalous regulation leads to cancerous conditions. PI3K? inhibition completely blocks the cancer signalling pathway, hence it can be explored as an important therapeutic target for cancer treatment. In the present study, docking analysis of 49 selective imidazo[1,2-a]pyrazine inhibitors of PI3K? was carried out using the QM-Polarized ligand docking (QPLD) program of the Schrdinger software, followed by the refinement of receptor-ligand conformations using the Hybrid Monte Carlo algorithm in the Liaison program, and alignment of refined conformations of inhibitors was utilized for the development of an atom-based 3D-QSAR model in the PHASE program. Among the five generated models, the best model was selected corresponding to PLS factor 2, displaying the highest value of Q(2)test (0.650). The selected model also displayed high values of r(2)train (0.917), F-value (166.5) and Pearson-r (0.877) and a low value of SD (0.265). The contour plots generated for the selected 3D-QSAR model were correlated with the results of docking simulations. Finally, this combined information generated from 3D-QSAR and docking analysis was used to design new congeners. PMID:24601789

  9. A hybrid approach for integrated healthcare cooperative purchasing and supply chain configuration.

    PubMed

    Rego, Nazaré; Claro, João; Pinho de Sousa, Jorge

    2014-12-01

    This paper presents an innovative and flexible approach for recommending the number, size and composition of purchasing groups, for a set of hospitals willing to cooperate, while minimising their shared supply chain costs. This approach makes the financial impact of the various cooperation alternatives transparent to the group and the individual participants, opening way to a negotiation process concerning the allocation of the cooperation costs and gains. The approach was developed around a hybrid Variable Neighbourhood Search (VNS)/Tabu Search metaheuristic, resulting in a flexible tool that can be applied to purchasing groups with different characteristics, namely different operative and market circumstances, and to supply chains with different topologies and atypical cost characteristics. Preliminary computational results show the potential of the approach in solving a broad range of problems. PMID:24370921

  10. The prescribing clinical health psychologist: a hybrid skill set in the new era of integrated healthcare.

    PubMed

    McGuinness, Kevin M

    2012-12-01

    The prescribing clinical health psychologist brings together in one individual a combination of skills to create a hybrid profession that can add value to any healthcare organization. This article addresses the high demand for mental health services and the inequitable distribution of mental health practitioners across the nation. The close link between physical and mental health and evidence that individuals in psychological distress often enter the mental health system via primary care medical clinics is offered as background to a discussion of the author's work as a commissioned officer of the U.S. Public Health Service assigned to the Chaparral Medical Center of La Clinica de Familia, Inc. near the U.S.-Mexico border. The prescribing clinical health psychologist in primary care medical settings is described as a valuable asset to the future of professional psychology. PMID:23179075

  11. Monte Carlo Transport for Electron Thermal Transport

    NASA Astrophysics Data System (ADS)

    Chenhall, Jeffrey; Cao, Duc; Moses, Gregory

    2015-11-01

    The iSNB (implicit Schurtz Nicolai Busquet multigroup electron thermal transport method of Cao et al. is adapted into a Monte Carlo transport method in order to better model the effects of non-local behavior. The end goal is a hybrid transport-diffusion method that combines Monte Carlo Transport with a discrete diffusion Monte Carlo (DDMC). The hybrid method will combine the efficiency of a diffusion method in short mean free path regions with the accuracy of a transport method in long mean free path regions. The Monte Carlo nature of the approach allows the algorithm to be massively parallelized. Work to date on the method will be presented. This work was supported by Sandia National Laboratory - Albuquerque and the University of Rochester Laboratory for Laser Energetics.

  12. Whole-body hybrid imaging concept for the integration of PET/MR into radiation therapy treatment planning

    NASA Astrophysics Data System (ADS)

    Paulus, Daniel H.; Oehmigen, Mark; Grueneisen, Johannes; Umutlu, Lale; Quick, Harald H.

    2016-05-01

    Modern radiation therapy (RT) treatment planning is based on multimodality imaging. With the recent availability of whole-body PET/MR hybrid imaging new opportunities arise to improve target volume delineation in RT treatment planning. This, however, requires dedicated RT equipment for reproducible patient positioning on the PET/MR system, which has to be compatible with MR and PET imaging. A prototype flat RT table overlay, radiofrequency (RF) coil holders for head imaging, and RF body bridges for body imaging were developed and tested towards PET/MR system integration. Attenuation correction (AC) of all individual RT components was performed by generating 3D CT-based template models. A custom-built program for μ-map generation assembles all AC templates depending on the presence and position of each RT component. All RT devices were evaluated in phantom experiments with regards to MR and PET imaging compatibility, attenuation correction, PET quantification, and position accuracy. The entire RT setup was then evaluated in a first PET/MR patient study on five patients at different body regions. All tested devices are PET/MR compatible and do not produce visible artifacts or disturb image quality. The RT components showed a repositioning accuracy of better than 2 mm. Photon attenuation of  ‑11.8% in the top part of the phantom was observable, which was reduced to  ‑1.7% with AC using the μ-map generator. Active lesions of 3 subjects were evaluated in terms of SUVmean and an underestimation of  ‑10.0% and  ‑2.4% was calculated without and with AC of the RF body bridges, respectively. The new dedicated RT equipment for hybrid PET/MR imaging enables acquisitions in all body regions. It is compatible with PET/MR imaging and all hardware components can be corrected in hardware AC by using the suggested μ-map generator. These developments provide the technical and methodological basis for integration of PET/MR hybrid imaging into RT planning.

  13. Whole-body hybrid imaging concept for the integration of PET/MR into radiation therapy treatment planning.

    PubMed

    Paulus, Daniel H; Oehmigen, Mark; Grüneisen, Johannes; Umutlu, Lale; Quick, Harald H

    2016-05-01

    Modern radiation therapy (RT) treatment planning is based on multimodality imaging. With the recent availability of whole-body PET/MR hybrid imaging new opportunities arise to improve target volume delineation in RT treatment planning. This, however, requires dedicated RT equipment for reproducible patient positioning on the PET/MR system, which has to be compatible with MR and PET imaging. A prototype flat RT table overlay, radiofrequency (RF) coil holders for head imaging, and RF body bridges for body imaging were developed and tested towards PET/MR system integration. Attenuation correction (AC) of all individual RT components was performed by generating 3D CT-based template models. A custom-built program for μ-map generation assembles all AC templates depending on the presence and position of each RT component. All RT devices were evaluated in phantom experiments with regards to MR and PET imaging compatibility, attenuation correction, PET quantification, and position accuracy. The entire RT setup was then evaluated in a first PET/MR patient study on five patients at different body regions. All tested devices are PET/MR compatible and do not produce visible artifacts or disturb image quality. The RT components showed a repositioning accuracy of better than 2 mm. Photon attenuation of  -11.8% in the top part of the phantom was observable, which was reduced to  -1.7% with AC using the μ-map generator. Active lesions of 3 subjects were evaluated in terms of SUVmean and an underestimation of  -10.0% and  -2.4% was calculated without and with AC of the RF body bridges, respectively. The new dedicated RT equipment for hybrid PET/MR imaging enables acquisitions in all body regions. It is compatible with PET/MR imaging and all hardware components can be corrected in hardware AC by using the suggested μ-map generator. These developments provide the technical and methodological basis for integration of PET/MR hybrid imaging into RT planning. PMID:27055014

  14. Radiation hardness assessment of the charge-integrating hybrid pixel detector JUNGFRAU 1.0 for photon science

    SciTech Connect

    Jungmann-Smith, J. H. Bergamaschi, A.; Brückner, M.; Dinapoli, R.; Greiffenberg, D.; Jaggi, A.; Maliakal, D.; Mayilyan, D.; Mezza, D.; Mozzanica, A.; Ramilli, M.; Ruder, Ch.; Schädler, L.; Schmitt, B.; Shi, X.; Tinti, G.; Cartier, S.; Medjoubi, K.

    2015-12-15

    JUNGFRAU (adJUstiNg Gain detector FoR the Aramis User station) is a two-dimensional hybrid pixel detector for photon science applications in free electron lasers, particularly SwissFEL, and synchrotron light sources. JUNGFRAU is an automatic gain switching, charge-integrating detector which covers a dynamic range of more than 10{sup 4} photons of an energy of 12 keV with a good linearity, uniformity of response, and spatial resolving power. The JUNGFRAU 1.0 application-specific integrated circuit (ASIC) features a 256 × 256 pixel matrix of 75 × 75 μm{sup 2} pixels and is bump-bonded to a 320 μm thick Si sensor. Modules of 2 × 4 chips cover an area of about 4 × 8 cm{sup 2}. Readout rates in excess of 2 kHz enable linear count rate capabilities of 20 MHz (at 12 keV) and 50 MHz (at 5 keV). The tolerance of JUNGFRAU to radiation is a key issue to guarantee several years of operation at free electron lasers and synchrotrons. The radiation hardness of JUNGFRAU 1.0 is tested with synchrotron radiation up to 10 MGy of delivered dose. The effect of radiation-induced changes on the noise, baseline, gain, and gain switching is evaluated post-irradiation for both the ASIC and the hybridized assembly. The bare JUNGFRAU 1.0 chip can withstand doses as high as 10 MGy with minor changes to its noise and a reduction in the preamplifier gain. The hybridized assembly, in particular the sensor, is affected by the photon irradiation which mainly shows as an increase in the leakage current. Self-healing of the system is investigated during a period of 11 weeks after the delivery of the radiation dose. Annealing radiation-induced changes by bake-out at 100 °C is investigated. It is concluded that the JUNGFRAU 1.0 pixel is sufficiently radiation-hard for its envisioned applications at SwissFEL and synchrotron beam lines.

  15. Radiation hardness assessment of the charge-integrating hybrid pixel detector JUNGFRAU 1.0 for photon science

    NASA Astrophysics Data System (ADS)

    Jungmann-Smith, J. H.; Bergamaschi, A.; Brückner, M.; Cartier, S.; Dinapoli, R.; Greiffenberg, D.; Jaggi, A.; Maliakal, D.; Mayilyan, D.; Medjoubi, K.; Mezza, D.; Mozzanica, A.; Ramilli, M.; Ruder, Ch.; Schädler, L.; Schmitt, B.; Shi, X.; Tinti, G.

    2015-12-01

    JUNGFRAU (adJUstiNg Gain detector FoR the Aramis User station) is a two-dimensional hybrid pixel detector for photon science applications in free electron lasers, particularly SwissFEL, and synchrotron light sources. JUNGFRAU is an automatic gain switching, charge-integrating detector which covers a dynamic range of more than 104 photons of an energy of 12 keV with a good linearity, uniformity of response, and spatial resolving power. The JUNGFRAU 1.0 application-specific integrated circuit (ASIC) features a 256 × 256 pixel matrix of 75 × 75 μm2 pixels and is bump-bonded to a 320 μm thick Si sensor. Modules of 2 × 4 chips cover an area of about 4 × 8 cm2. Readout rates in excess of 2 kHz enable linear count rate capabilities of 20 MHz (at 12 keV) and 50 MHz (at 5 keV). The tolerance of JUNGFRAU to radiation is a key issue to guarantee several years of operation at free electron lasers and synchrotrons. The radiation hardness of JUNGFRAU 1.0 is tested with synchrotron radiation up to 10 MGy of delivered dose. The effect of radiation-induced changes on the noise, baseline, gain, and gain switching is evaluated post-irradiation for both the ASIC and the hybridized assembly. The bare JUNGFRAU 1.0 chip can withstand doses as high as 10 MGy with minor changes to its noise and a reduction in the preamplifier gain. The hybridized assembly, in particular the sensor, is affected by the photon irradiation which mainly shows as an increase in the leakage current. Self-healing of the system is investigated during a period of 11 weeks after the delivery of the radiation dose. Annealing radiation-induced changes by bake-out at 100 °C is investigated. It is concluded that the JUNGFRAU 1.0 pixel is sufficiently radiation-hard for its envisioned applications at SwissFEL and synchrotron beam lines.

  16. Radiation hardness assessment of the charge-integrating hybrid pixel detector JUNGFRAU 1.0 for photon science.

    PubMed

    Jungmann-Smith, J H; Bergamaschi, A; Brückner, M; Cartier, S; Dinapoli, R; Greiffenberg, D; Jaggi, A; Maliakal, D; Mayilyan, D; Medjoubi, K; Mezza, D; Mozzanica, A; Ramilli, M; Ruder, Ch; Schädler, L; Schmitt, B; Shi, X; Tinti, G

    2015-12-01

    JUNGFRAU (adJUstiNg Gain detector FoR the Aramis User station) is a two-dimensional hybrid pixel detector for photon science applications in free electron lasers, particularly SwissFEL, and synchrotron light sources. JUNGFRAU is an automatic gain switching, charge-integrating detector which covers a dynamic range of more than 10(4) photons of an energy of 12 keV with a good linearity, uniformity of response, and spatial resolving power. The JUNGFRAU 1.0 application-specific integrated circuit (ASIC) features a 256 × 256 pixel matrix of 75 × 75 μm(2) pixels and is bump-bonded to a 320 μm thick Si sensor. Modules of 2 × 4 chips cover an area of about 4 × 8 cm(2). Readout rates in excess of 2 kHz enable linear count rate capabilities of 20 MHz (at 12 keV) and 50 MHz (at 5 keV). The tolerance of JUNGFRAU to radiation is a key issue to guarantee several years of operation at free electron lasers and synchrotrons. The radiation hardness of JUNGFRAU 1.0 is tested with synchrotron radiation up to 10 MGy of delivered dose. The effect of radiation-induced changes on the noise, baseline, gain, and gain switching is evaluated post-irradiation for both the ASIC and the hybridized assembly. The bare JUNGFRAU 1.0 chip can withstand doses as high as 10 MGy with minor changes to its noise and a reduction in the preamplifier gain. The hybridized assembly, in particular the sensor, is affected by the photon irradiation which mainly shows as an increase in the leakage current. Self-healing of the system is investigated during a period of 11 weeks after the delivery of the radiation dose. Annealing radiation-induced changes by bake-out at 100 °C is investigated. It is concluded that the JUNGFRAU 1.0 pixel is sufficiently radiation-hard for its envisioned applications at SwissFEL and synchrotron beam lines. PMID:26724009

  17. Hybrid graphene/silicon integrated optical isolators with photonic spin-orbit interaction

    NASA Astrophysics Data System (ADS)

    Ma, Jingwen; Xi, Xiang; Yu, Zejie; Sun, Xiankai

    2016-04-01

    Optical isolators are an important building block in photonic computation and communication. In traditional optics, isolators are realized with magneto-optical garnets. However, it remains challenging to incorporate such materials on an integrated platform because of the difficulty in material growth and bulky device footprint. Here, we propose an ultracompact integrated isolator by exploiting graphene's magneto-optical property on a silicon-on-insulator platform. The photonic nonreciprocity is achieved because the cyclotrons in graphene experiencing different optical spins exhibit different responses to counterpropagating light. Taking advantage of cavity resonance effects, we have numerically optimized a device design, which shows excellent isolation performance with the extinction ratio over 45 dB and the insertion loss around 12 dB at a wavelength near 1.55 μm. Featuring graphene's CMOS compatibility and substantially reduced device footprint, our proposal sheds light on monolithic integration of nonreciprocal photonic devices.

  18. Using Integrated Course Design to Build Student Communities of Practice in a Hybrid Course

    ERIC Educational Resources Information Center

    Fayne, Harriet R.

    2009-01-01

    In this article, the author describes how she used integrated course design to design a course that would help special education teachers satisfy the "Highly Qualified Teacher" (HQT) requirement established by No Child Left Behind (NCLB) in the area of English/language arts. The approach she chose was based on principles advanced by Fink in

  19. Development of an Integrated GIS and Land Use Planning Course: Impacts of Hybrid Instructional Methods

    ERIC Educational Resources Information Center

    Kamruzzaman, M.

    2014-01-01

    This study reports an action research undertaken at Queensland University of Technology. It evaluates the effectiveness of the integration of geographic information systems (GIS) within the substantive domains of an existing land use planning course in 2011. Using student performance, learning experience survey, and questionnaire survey data, it…

  20. Development of an Integrated GIS and Land Use Planning Course: Impacts of Hybrid Instructional Methods

    ERIC Educational Resources Information Center

    Kamruzzaman, M.

    2014-01-01

    This study reports an action research undertaken at Queensland University of Technology. It evaluates the effectiveness of the integration of geographic information systems (GIS) within the substantive domains of an existing land use planning course in 2011. Using student performance, learning experience survey, and questionnaire survey data, it

  1. HORIZONTAL HYBRID SOLAR LIGHT PIPE: AN INTEGRATED SYSTEM OF DAYLIGHT AND ELECTRIC LIGHT

    EPA Science Inventory

    This project will test the feasibility of an advanced energy efficient perimeter lighting system that integrates daylighting, electric lighting, and lighting controls to reduce electricity consumption. The system is designed to provide adequate illuminance levels in deep-floor...

  2. Surface integral and finite element hybrid method for three-dimensional analysis of arbitrarily shaped surface cracks

    SciTech Connect

    Keat, W.D.; Maybury, D.M.; Annigeri, B.S.

    1996-04-01

    A three-dimensional surface integral and finite element hybrid method has been developed for modeling arbitrarily shaped surface cracks in complex structural components. Accurate stress intensity factors were obtained by decomposing the problem into a surface integral model of the fracture in a domain of infinite extent and a finite element model of the uncracked domain. Boundary conditions were enforced by applying corrective traction to the surfaces of both constituent models. Coupling between the two formulations was minimized by implementing the fundamental solution for a force multipole near a planar free surface. Surface cracks intersecting nonplanar free surfaces were modeled in a piecewise linear fashion by deploying multiple sets of these functions. The effectiveness of this approach was demonstrated for well-documented cases, including a corner crack in a thick plate and a three-dimensional edge crack. The results of these benchmark studies will be used to develop a set of heuristics for assuring suitable finite element mesh densities in the vicinity of the fracture.

  3. Integrated thermal and energy management of plug-in hybrid electric vehicles

    NASA Astrophysics Data System (ADS)

    Shams-Zahraei, Mojtaba; Kouzani, Abbas Z.; Kutter, Steffen; Bäker, Bernard

    2012-10-01

    In plug-in hybrid electric vehicles (PHEVs), the engine temperature declines due to reduced engine load and extended engine off period. It is proven that the engine efficiency and emissions depend on the engine temperature. Also, temperature influences the vehicle air-conditioner and the cabin heater loads. Particularly, while the engine is cold, the power demand of the cabin heater needs to be provided by the batteries instead of the waste heat of engine coolant. The existing energy management strategies (EMS) of PHEVs focus on the improvement of fuel efficiency based on hot engine characteristics neglecting the effect of temperature on the engine performance and the vehicle power demand. This paper presents a new EMS incorporating an engine thermal management method which derives the global optimal battery charge depletion trajectories. A dynamic programming-based algorithm is developed to enforce the charge depletion boundaries, while optimizing a fuel consumption cost function by controlling the engine power. The optimal control problem formulates the cost function based on two state variables: battery charge and engine internal temperature. Simulation results demonstrate that temperature and the cabin heater/air-conditioner power demand can significantly influence the optimal solution for the EMS, and accordingly fuel efficiency and emissions of PHEVs.

  4. Integration of organic LEDs with inorganic LEDs for a hybrid lighting system

    NASA Astrophysics Data System (ADS)

    Kong, H. J.; Park, J. W.; Kim, Y. M.

    2013-01-01

    We demonstrate that a surface-emitting hybrid light source can be realized by a combination of organic and inorganic light-emitting devices (LEDs). To this end, a blue inorganic LED bar is deployed at one side of a transparent light guide plate (LGP), and a yellow organic LED (OLED) is in contact with the rear surface of the LGP. In such a configuration, it is found that the overall luminance is almost equivalent to the sum of the luminances measured from each light source, and the overall luminance uniformity is determined mainly by the luminance uniformity of the OLED panel at high luminances. We have achieved a white color showing the Commission Internationale d'Eclairage (CIE) chromaticity coordinates of (x = 0.34, y = 0.33), the power efficiency of 9.3 lm/W, the luminance uniformity of 63% at the luminance of 3100 cd m-2, the color rendering index as high as 89.3, and the correlated color temperature finely tunable within the range between 3000 and 8000 K. Such a system facilitates color tuning by adjusting their luminous intensities and hence the implementation of the emotional lighting system.

  5. Cubic PdNP-based air-breathing cathodes integrated in glucose hybrid biofuel cells.

    PubMed

    Faggion Junior, D; Haddad, R; Giroud, F; Holzinger, M; Maduro de Campos, C E; Acuña, J J S; Domingos, J B; Cosnier, S

    2016-05-21

    Cubic Pd nanoparticles (PdNPs) were synthesized using ascorbic acid as a reducing agent and were evaluated for the catalytic oxygen reduction reaction. PdNPs were confined with multiwalled carbon nanotube (MWCNT) dispersions to form black suspensions and these inks were dropcast onto glassy carbon electrodes. Different nanoparticle sizes were synthesized and investigated upon oxygen reduction capacities (onset potential and electrocatalytic current densities) under O2 saturated conditions at varying pH values. Strong evidence of O2 diffusion limitation was demonstrated. In order to overcome oxygen concentration and diffusion limitations in solution, we used a gas diffusion layer to create a PdNP-based air-breathing cathode, which delivered -1.5 mA cm(-2) at 0.0 V with an onset potential of 0.4 V. This air-breathing cathode was combined with a specially designed phenanthrolinequinone/glucose dehydrogenase-based anode to form a complete glucose/O2 hybrid bio-fuel cell providing an open circuit voltage of 0.554 V and delivering a maximal power output of 184 ± 21 μW cm(-2) at 0.19 V and pH 7.0. PMID:27142300

  6. Integrating climate change criteria in reforestation projects using a hybrid decision-support system

    NASA Astrophysics Data System (ADS)

    Curiel-Esparza, Jorge; Gonzalez-Utrillas, Nuria; Canto-Perello, Julian; Martin-Utrillas, Manuel

    2015-09-01

    The selection of appropriate species in a reforestation project has always been a complex decision-making problem in which, due mostly to government policies and other stakeholders, not only economic criteria but also other environmental issues interact. Climate change has not usually been taken into account in traditional reforestation decision-making strategies and management procedures. Moreover, there is a lack of agreement on the percentage of each one of the species in reforestation planning, which is usually calculated in a discretionary way. In this context, an effective multicriteria technique has been developed in order to improve the process of selecting species for reforestation in the Mediterranean region of Spain. A hybrid Delphi-AHP methodology is proposed, which includes a consistency analysis in order to reduce random choices. As a result, this technique provides an optimal percentage distribution of the appropriate species to be used in reforestation planning. The highest values of the weight given for each subcriteria corresponded to FR (fire forest response) and PR (pests and diseases risk), because of the increasing importance of the impact of climate change in the forest. However, CB (conservation of biodiversitiy) was in the third position in line with the aim of reforestation. Therefore, the most suitable species were Quercus faginea (19.75%) and Quercus ilex (19.35%), which offer a good balance between all the factors affecting the success and viability of reforestation.

  7. Inefficiency of orientation averaging: Evidence for hybrid serial/parallel temporal integration.

    PubMed

    Solomon, Joshua A; May, Keith A; Tyler, Christopher W

    2016-01-01

    Intuition suggests that increased viewing time should allow for the accumulation of more visual information, but scant support for this idea has been found in studies of voluntary averaging, where observers are asked to make decisions based on perceived average size. In this paper we examine the dynamics of information accrual in an orientation-averaging task. With orientation (unlike intensive dimensions such as size), it is relatively safe to use an item's physical value as an approximation for its average perceived value. We displayed arrays containing eight iso-eccentric Gabor patterns, and asked six trained psychophysical observers to compare their average orientation with that of probe stimuli that were visible before, during, or only after the presentation of the Gabor array. From the relationship between orientation variance and human performance, we obtained estimates of effective set size, i.e., the number of items that an ideal observer would need to assess in order to estimate average orientation as well as our human observers did. We found that display duration had only a modest influence on effective set size. It rose from an average of ∼2 for 0.1-s displays to an average of ∼3 for 3.3-s displays. These results suggest that the visual computation is neither purely serial nor purely parallel. Computations of this nature can be made with a hybrid process that takes a series of subsamples of a few elements at a time. PMID:26790845

  8. Hybrid information privacy system: integration of chaotic neural network and RSA coding

    NASA Astrophysics Data System (ADS)

    Hsu, Ming-Kai; Willey, Jeff; Lee, Ting N.; Szu, Harold H.

    2005-03-01

    Electronic mails are adopted worldwide; most are easily hacked by hackers. In this paper, we purposed a free, fast and convenient hybrid privacy system to protect email communication. The privacy system is implemented by combining private security RSA algorithm with specific chaos neural network encryption process. The receiver can decrypt received email as long as it can reproduce the specified chaos neural network series, so called spatial-temporal keys. The chaotic typing and initial seed value of chaos neural network series, encrypted by the RSA algorithm, can reproduce spatial-temporal keys. The encrypted chaotic typing and initial seed value are hidden in watermark mixed nonlinearly with message media, wrapped with convolution error correction codes for wireless 3rd generation cellular phones. The message media can be an arbitrary image. The pattern noise has to be considered during transmission and it could affect/change the spatial-temporal keys. Since any change/modification on chaotic typing or initial seed value of chaos neural network series is not acceptable, the RSA codec system must be robust and fault-tolerant via wireless channel. The robust and fault-tolerant properties of chaos neural networks (CNN) were proved by a field theory of Associative Memory by Szu in 1997. The 1-D chaos generating nodes from the logistic map having arbitrarily negative slope a = p/q generating the N-shaped sigmoid was given first by Szu in 1992. In this paper, we simulated the robust and fault-tolerance properties of CNN under additive noise and pattern noise. We also implement a private version of RSA coding and chaos encryption process on messages.

  9. Monte Carlo methods on advanced computer architectures

    SciTech Connect

    Martin, W.R.

    1991-12-31

    Monte Carlo methods describe a wide class of computational methods that utilize random numbers to perform a statistical simulation of a physical problem, which itself need not be a stochastic process. For example, Monte Carlo can be used to evaluate definite integrals, which are not stochastic processes, or may be used to simulate the transport of electrons in a space vehicle, which is a stochastic process. The name Monte Carlo came about during the Manhattan Project to describe the new mathematical methods being developed which had some similarity to the games of chance played in the casinos of Monte Carlo. Particle transport Monte Carlo is just one application of Monte Carlo methods, and will be the subject of this review paper. Other applications of Monte Carlo, such as reliability studies, classical queueing theory, molecular structure, the study of phase transitions, or quantum chromodynamics calculations for basic research in particle physics, are not included in this review. The reference by Kalos is an introduction to general Monte Carlo methods and references to other applications of Monte Carlo can be found in this excellent book. For the remainder of this paper, the term Monte Carlo will be synonymous to particle transport Monte Carlo, unless otherwise noted. 60 refs., 14 figs., 4 tabs.

  10. Chromosome-Specific Single-Locus FISH Probes Allow Anchorage of an 1800-Marker Integrated Radiation-Hybrid/Linkage Map of the Domestic Dog Genome to All Chromosomes

    PubMed Central

    Breen, Matthew; Jouquand, Sophie; Renier, Corinne; Mellersh, Cathryn S.; Hitte, Christophe; Holmes, Nigel G.; Chéron, Angélique; Suter, Nicola; Vignaux, Françoise; Bristow, Anna E.; Priat, Catherine; McCann, E.; André, Catherine; Boundy, Sam; Gitsham, Paul; Thomas, Rachael; Bridge, Wendy L.; Spriggs, Helen F.; Ryder, Ed J.; Curson, Alistair; Sampson, Jeff; Ostrander, Elaine A.; Binns, Matthew M.; Galibert, Francis

    2001-01-01

    We present here the first fully integrated, comprehensive map of the canine genome, incorporating detailed cytogenetic, radiation hybrid (RH), and meiotic information. We have mapped a collection of 266 chromosome-specific cosmid clones, each containing a microsatellite marker, to all 38 canine autosomes by fluorescence in situ hybridization (FISH). A 1500-marker RH map, comprising 1078 microsatellites, 320 dog gene markers, and 102 chromosome-specific markers, has been constructed using the RHDF5000-2 whole-genome radiation hybrid panel. Meiotic linkage analysis was performed, with at least one microsatellite marker from each dog autosome on a panel of reference families, allowing one meiotic linkage group to be anchored to all 38 dog autosomes. We present a karyotype in which each chromosome is identified by one meiotic linkage group and one or more RH groups. This updated integrated map, containing a total of 1800 markers, covers >90% of the dog genome. Positional selection of anchor clones enabled us, for the first time, to orientate nearly all of the integrated groups on each chromosome and to evaluate the extent of individual chromosome coverage in the integrated genome map. Finally, the inclusion of 320 dog genes into this integrated map enhances existing comparative mapping data between human and dog, and the 1000 mapped microsatellite markers constitute an invaluable tool with which to perform genome scanning studies on pedigrees of interest. PMID:11591656

  11. Dynamic modeling, experimental evaluation, optimal design and control of integrated fuel cell system and hybrid energy systems for building demands

    NASA Astrophysics Data System (ADS)

    Nguyen, Gia Luong Huu

    Fuel cells can produce electricity with high efficiency, low pollutants, and low noise. With the advent of fuel cell technologies, fuel cell systems have since been demonstrated as reliable power generators with power outputs from a few watts to a few megawatts. With proper equipment, fuel cell systems can produce heating and cooling, thus increased its overall efficiency. To increase the acceptance from electrical utilities and building owners, fuel cell systems must operate more dynamically and integrate well with renewable energy resources. This research studies the dynamic performance of fuel cells and the integration of fuel cells with other equipment in three levels: (i) the fuel cell stack operating on hydrogen and reformate gases, (ii) the fuel cell system consisting of a fuel reformer, a fuel cell stack, and a heat recovery unit, and (iii) the hybrid energy system consisting of photovoltaic panels, fuel cell system, and energy storage. In the first part, this research studied the steady-state and dynamic performance of a high temperature PEM fuel cell stack. Collaborators at Aalborg University (Aalborg, Denmark) conducted experiments on a high temperature PEM fuel cell short stack at steady-state and transients. Along with the experimental activities, this research developed a first-principles dynamic model of a fuel cell stack. The dynamic model developed in this research was compared to the experimental results when operating on different reformate concentrations. Finally, the dynamic performance of the fuel cell stack for a rapid increase and rapid decrease in power was evaluated. The dynamic model well predicted the performance of the well-performing cells in the experimental fuel cell stack. The second part of the research studied the dynamic response of a high temperature PEM fuel cell system consisting of a fuel reformer, a fuel cell stack, and a heat recovery unit with high thermal integration. After verifying the model performance with the obtained experimental data, the research studied the control of airflow to regulate the temperature of reactors within the fuel processor. The dynamic model provided a platform to test the dynamic response for different control gains. With sufficient sensing and appropriate control, a rapid response to maintain the temperature of the reactor despite an increase in power was possible. The third part of the research studied the use of a fuel cell in conjunction with photovoltaic panels, and energy storage to provide electricity for buildings. This research developed an optimization framework to determine the size of each device in the hybrid energy system to satisfy the electrical demands of buildings and yield the lowest cost. The advantage of having the fuel cell with photovoltaic and energy storage was the ability to operate the fuel cell at baseload at night, thus reducing the need for large battery systems to shift the solar power produced in the day to the night. In addition, the dispatchability of the fuel cell provided an extra degree of freedom necessary for unforeseen disturbances. An operation framework based on model predictive control showed that the method is suitable for optimizing the dispatch of the hybrid energy system.

  12. Free-space coherent optical communication with orbital angular, momentum multiplexing/demultiplexing using a hybrid 3D photonic integrated circuit.

    PubMed

    Guan, Binbin; Scott, Ryan P; Qin, Chuan; Fontaine, Nicolas K; Su, Tiehui; Ferrari, Carlo; Cappuzzo, Mark; Klemens, Fred; Keller, Bob; Earnshaw, Mark; Yoo, S J B

    2014-01-13

    We demonstrate free-space space-division-multiplexing (SDM) with 15 orbital angular momentum (OAM) states using a three-dimensional (3D) photonic integrated circuit (PIC). The hybrid device consists of a silica planar lightwave circuit (PLC) coupled to a 3D waveguide circuit to multiplex/demultiplex OAM states. The low excess loss hybrid device is used in individual and two simultaneous OAM states multiplexing and demultiplexing link experiments with a 20 Gb/s, 1.67 b/s/Hz quadrature phase shift keyed (QPSK) signal, which shows error-free performance for 379,960 tested bits for all OAM states. PMID:24514976

  13. Investigation of the effects of laser non-linearity and RIN in direct modulation hybrid wired/wireless PON systems employing an integrated two section laser

    NASA Astrophysics Data System (ADS)

    Saljoghei, Arsalan; Browning, Colm; Smyth, Frank; Barry, Liam P.

    2015-03-01

    In this paper the transmission of OFDM based wired/wireless services for hybrid PONs using direct laser modulation is studied. To overcome the limitations imposed by direct modulation of cost effective low bandwidth laser transmitters, we make use of novel monolithically integrated Discrete Mode lasers and optical injection. The system includes a wired OFDM signal, operating at 12.5 Gb/s and three wireless signals delivering Long Term Evolution (LTE) services encoded with 16 QAM. The system's performance is evaluated for various relative power ratios of the wired/wireless signals. Additionally, the impact of Relative Intensity Noise (RIN) on such a hybrid system is studied through computer simulations.

  14. Hybrid Pixel-Based Method for Cardiac Ultrasound Fusion Based on Integration of PCA and DWT

    PubMed Central

    Sulaiman, Puteri Suhaiza; Wirza, Rahmita; Dimon, Mohd Zamrin; Khalid, Fatimah; Moosavi Tayebi, Rohollah

    2015-01-01

    Medical image fusion is the procedure of combining several images from one or multiple imaging modalities. In spite of numerous attempts in direction of automation ventricle segmentation and tracking in echocardiography, due to low quality images with missing anatomical details or speckle noises and restricted field of view, this problem is a challenging task. This paper presents a fusion method which particularly intends to increase the segment-ability of echocardiography features such as endocardial and improving the image contrast. In addition, it tries to expand the field of view, decreasing impact of noise and artifacts and enhancing the signal to noise ratio of the echo images. The proposed algorithm weights the image information regarding an integration feature between all the overlapping images, by using a combination of principal component analysis and discrete wavelet transform. For evaluation, a comparison has been done between results of some well-known techniques and the proposed method. Also, different metrics are implemented to evaluate the performance of proposed algorithm. It has been concluded that the presented pixel-based method based on the integration of PCA and DWT has the best result for the segment-ability of cardiac ultrasound images and better performance in all metrics. PMID:26089965

  15. A critical evaluation of secondary cancer risk models applied to Monte Carlo dose distributions of 2-dimensional, 3-dimensional conformal and hybrid intensity-modulated radiation therapy for breast cancer.

    PubMed

    Joosten, A; Bochud, F; Moeckli, R

    2014-08-21

    The comparison of radiotherapy techniques regarding secondary cancer risk has yielded contradictory results possibly stemming from the many different approaches used to estimate risk. The purpose of this study was to make a comprehensive evaluation of different available risk models applied to detailed whole-body dose distributions computed by Monte Carlo for various breast radiotherapy techniques including conventional open tangents, 3D conformal wedged tangents and hybrid intensity modulated radiation therapy (IMRT). First, organ-specific linear risk models developed by the International Commission on Radiological Protection (ICRP) and the Biological Effects of Ionizing Radiation (BEIR) VII committee were applied to mean doses for remote organs only and all solid organs. Then, different general non-linear risk models were applied to the whole body dose distribution. Finally, organ-specific non-linear risk models for the lung and breast were used to assess the secondary cancer risk for these two specific organs. A total of 32 different calculated absolute risks resulted in a broad range of values (between 0.1% and 48.5%) underlying the large uncertainties in absolute risk calculation. The ratio of risk between two techniques has often been proposed as a more robust assessment of risk than the absolute risk. We found that the ratio of risk between two techniques could also vary substantially considering the different approaches to risk estimation. Sometimes the ratio of risk between two techniques would range between values smaller and larger than one, which then translates into inconsistent results on the potential higher risk of one technique compared to another. We found however that the hybrid IMRT technique resulted in a systematic reduction of risk compared to the other techniques investigated even though the magnitude of this reduction varied substantially with the different approaches investigated. Based on the epidemiological data available, a reasonable approach to risk estimation would be to use organ-specific non-linear risk models applied to the dose distributions of organs within or near the treatment fields (lungs and contralateral breast in the case of breast radiotherapy) as the majority of radiation-induced secondary cancers are found in the beam-bordering regions. PMID:25082795

  16. A critical evaluation of secondary cancer risk models applied to Monte Carlo dose distributions of 2-dimensional, 3-dimensional conformal and hybrid intensity-modulated radiation therapy for breast cancer

    NASA Astrophysics Data System (ADS)

    Joosten, A.; Bochud, F.; Moeckli, R.

    2014-08-01

    The comparison of radiotherapy techniques regarding secondary cancer risk has yielded contradictory results possibly stemming from the many different approaches used to estimate risk. The purpose of this study was to make a comprehensive evaluation of different available risk models applied to detailed whole-body dose distributions computed by Monte Carlo for various breast radiotherapy techniques including conventional open tangents, 3D conformal wedged tangents and hybrid intensity modulated radiation therapy (IMRT). First, organ-specific linear risk models developed by the International Commission on Radiological Protection (ICRP) and the Biological Effects of Ionizing Radiation (BEIR) VII committee were applied to mean doses for remote organs only and all solid organs. Then, different general non-linear risk models were applied to the whole body dose distribution. Finally, organ-specific non-linear risk models for the lung and breast were used to assess the secondary cancer risk for these two specific organs. A total of 32 different calculated absolute risks resulted in a broad range of values (between 0.1% and 48.5%) underlying the large uncertainties in absolute risk calculation. The ratio of risk between two techniques has often been proposed as a more robust assessment of risk than the absolute risk. We found that the ratio of risk between two techniques could also vary substantially considering the different approaches to risk estimation. Sometimes the ratio of risk between two techniques would range between values smaller and larger than one, which then translates into inconsistent results on the potential higher risk of one technique compared to another. We found however that the hybrid IMRT technique resulted in a systematic reduction of risk compared to the other techniques investigated even though the magnitude of this reduction varied substantially with the different approaches investigated. Based on the epidemiological data available, a reasonable approach to risk estimation would be to use organ-specific non-linear risk models applied to the dose distributions of organs within or near the treatment fields (lungs and contralateral breast in the case of breast radiotherapy) as the majority of radiation-induced secondary cancers are found in the beam-bordering regions.

  17. Propulsion Airframe Aeroacoustic Integration Effects for a Hybrid Wing Body Aircraft Configuration

    NASA Technical Reports Server (NTRS)

    Czech, Michael J.; Thomas, Russell H.; Elkoby, Ronen

    2010-01-01

    An extensive experimental investigation was performed to study the propulsion airframe aeroacoustic effects of a high bypass ratio engine for a hybrid wing body aircraft configuration where the engine is installed above the wing. The objective was to provide an understanding of the jet noise shielding effectiveness as a function of engine gas condition and location as well as nozzle configuration. A 4.7% scale nozzle of a bypass ratio seven engine was run at characteristic cycle points under static and forward flight conditions. The effect of the pylon and its orientation on jet noise was also studied as a function of bypass ratio and cycle condition. The addition of a pylon yielded significant spectral changes lowering jet noise by up to 4dB at high polar angles and increasing it by 2 to 3dB at forward angles. In order to assess jet noise shielding, a planform representation of the airframe model, also at 4.7% scale was traversed relative to the jet nozzle from downstream to several diameters upstream of the wing trailing edge. Installations at two fan diameters upstream of the wing trailing edge provided only limited shielding in the forward arc at high frequencies for both the axisymmetric and a conventional round nozzle with pylon. This was consistent with phased array measurements suggesting that the high frequency sources are predominantly located near the nozzle exit and, consequently, are amenable to shielding. The mid to low frequencies sources were observed further downstream and shielding was insignificant. Chevrons were designed and used to impact the distribution of sources with the more aggressive design showing a significant upstream migration of the sources in the mid frequency range. Furthermore, the chevrons reduced the low frequency source levels and the typical high frequency increase due to the application of chevron nozzles was successfully shielded. The pylon was further modified with a technology that injects air through the shelf of the pylon which was effective in reducing low frequency noise and moving jet noise sources closer to the nozzle exit. In general, shielding effectiveness varied as a function of cycle condition with the cutback condition producing higher shielding compared to sideline power. The configuration with a more strongly immersed chevron and a pylon oriented opposite to the microphones produced the largest reduction in jet noise. In addition to the jet noise source, the shielding of a broadband point noise source was documented with up to 20 dB of noise reduction at directivity angles directly under the shielding surface.

  18. Propulsion Airframe Aeroacoustic Integration Effects for a Hybrid Wing Body Aircraft Configuration

    NASA Technical Reports Server (NTRS)

    Czech, Michael J.; Thomas, Russell H; Elkoby, Ronen

    2012-01-01

    An extensive experimental investigation was performed to study the propulsion airframe aeroacoustic effects of a high bypass ratio engine for a hybrid wing body aircraft configuration where the engine is installed above the wing. The objective was to provide an understanding of the jet noise shielding effectiveness as a function of engine gas condition and location as well as nozzle configuration. A 4.7% scale nozzle of a bypass ratio seven engine was run at characteristic cycle points under static and forward flight conditions. The effect of the pylon and its orientation on jet noise was also studied as a function of bypass ratio and cycle condition. The addition of a pylon yielded significant spectral changes lowering jet noise by up to 4 dB at high polar angles and increasing it by 2 to 3 dB at forward angles. In order to assess jet noise shielding, a planform representation of the airframe model, also at 4.7% scale was traversed such that the jet nozzle was positioned from downstream of to several diameters upstream of the airframe model trailing edge. Installations at two fan diameters upstream of the wing trailing edge provided only limited shielding in the forward arc at high frequencies for both the axisymmetric and a conventional round nozzle with pylon. This was consistent with phased array measurements suggesting that the high frequency sources are predominantly located near the nozzle exit and, consequently, are amenable to shielding. The mid to low frequency sources were observed further downstream and shielding was insignificant. Chevrons were designed and used to impact the distribution of sources with the more aggressive design showing a significant upstream migration of the sources in the mid frequency range. Furthermore, the chevrons reduced the low frequency source levels and the typical high frequency increase due to the application of chevron nozzles was successfully shielded. The pylon was further modified with a technology that injects air through the shelf of the pylon which was effective in reducing low frequency noise and moving jet noise sources closer to the nozzle exit. In general, shielding effectiveness varied as a function of cycle condition with the cutback condition producing higher shielding compared to sideline power. The configuration with a more strongly immersed chevron and a pylon oriented opposite to the microphones produced the largest reduction in jet noise. In addition to the jet noise source, the shielding of a broadband point noise source was documented with up to 20 dB of noise reduction at directivity angles directly under the shielding surface.

  19. A 10Gb/s transimpedance amplifier for hybrid integration of a Ge PIN waveguide photodiode

    NASA Astrophysics Data System (ADS)

    Polzer, A.; Gaberl, W.; Swoboda, R.; Zimmermann, H.; Fedeli, J.-M.; Vivien, L.

    2010-05-01

    The presented paper describes a 10 Gbps optical receiver. The transimpedance amplifier (TIA) is realized in standard 0.35 μm SiGe BiCMOS technology. The main novelty of the presented design - investigated in the European Community project HELIOS - is the hybrid connection of the optical detector. The used Germanium photodetector will be directly mounted onto the receiver. A model of the relevant parasitics of the photodetector itself and the novel connection elements (micropads, metal vias and metal lines) is described. Based on this photodetector model an optical receiver circuit was optimized for maximum sensitivity at data rates in the range of 10 Gbps. The design combines a TIA and two limiting amplifier stages followed by a 50 Ω CML-style logic-level output driver. To minimize power supply noise and substrate noise, a fully differential design is used. A dummy TIA provides a symmetrical input signal reference and a control loop is used to compensate the offset levels. The TIA is built around a common-emitter stage and features a feedback resistor of 4.2 Ω. The total transimpedance of the complete receiver chain is in the range of 275 kΩ. The value of the active feedback resistor can be reduced via an external control voltage to adapt the design to different overall gain requirements. The two limiting amplifier stages are realized as differential amplifiers with voltage followers. The output buffer is implemented with cascode differential amplifiers. The output buffer is capable of driving a differential 50Ω output with a calculated output swing of 800mVp-p. Simulations show an overall bandwidth of 7.2 GHz. The lower cutoff frequency is below 60 kHz. The equivalent input noise current is 408 nA. With an estimated total photodiode responsivity of 0.5 A/W this allows a sensitivity of around - 23.1 dBm (BER = 10-9). The device operates from a single 3.3 V power supply and the TIAs and the limiting amplifier consume 32 mA.

  20. Field Test and Performance Verification: Integrated Active Desiccant Rooftop Hybrid System Installed in a School - Final Report: Phase 4A

    SciTech Connect

    Fischer, J

    2005-12-21

    This report summarizes the results of a field verification pilot site investigation that involved the installation of a hybrid integrated active desiccant/vapor-compression rooftop heating, ventilation, and air-conditioning (HVAC) unit at an elementary school in the Atlanta Georgia area. For years, the school had experienced serious humidity and indoor air quality (IAQ) problems that had resulted in occupant complaints and microbial (mold) remediation. The outdoor air louvers of the original HVAC units had been closed in an attempt to improve humidity control within the space. The existing vapor compression variable air volume system was replaced by the integrated active desiccant rooftop (IADR) system that was described in detail in an Oak Ridge National Laboratory (ORNL) report published in 2004 (Fischer and Sand 2004). The IADR system and all space conditions have been monitored remotely for more than a year. The hybrid system was able to maintain both the space temperature and humidity as desired while delivering the outdoor air ventilation rate required by American Society of Heating, Refrigerating and Air-Conditioning Engineers Standard 62. The performance level of the IADR unit and the overall system energy efficiency was measured and found to be very high. A comprehensive IAQ investigation was completed by the Georgia Tech Research Institute before and after the system retrofit. Before-and-after data resulting from this investigation confirmed a significant improvement in IAQ, humidity control, and occupant comfort. These observations were reported by building occupants and are echoed in a letter to ORNL from the school district energy manager. The IADR system was easily retrofitted in place of the original rooftop system using a custom curb adapter. All work was completed in-house by the school's maintenance staff over one weekend. A subsequent cost analysis completed for the school district by the design engineer of record concluded that the IADR system being investigated was actually less expensive to install than other less-efficient options, most of which were unable to deliver the required ventilation while maintaining the desired space humidity levels.

  1. Design and characterization of a hybrid-integrated MEMS scanning grating spectrometer

    NASA Astrophysics Data System (ADS)

    Grüger, Heinrich; Knobbe, Jens; Pügner, Tino; Schenk, Harald

    2013-03-01

    Grating spectrometer, like the well-established Czerny-Turner, are based on an optical design consisting of several components. Typically at least two slits, two mirrors, the grating stage and a detector are required. There has been much work to reduce this effort, setups using only one mirror (Ebert - Fastie) or the replacement of the entrance slit through the use of thin optical fibers as well as integrated electronic detector arrays instead of a moving grating and an exit slit and single detector device have been applied. Reduced effort comes along with performance limitations: Either the optical resolution or throughput is affected or the use of the system is limited to the availability of detectors arrays with reasonable price. Components in micro opto electro mechanical systems (MOEMS-) technology and spectroscopic systems based thereon have been developed to improve this situation. Miniaturized scanning gratings fabricated on bonded silicon on insulator (BSOI-) wafers were used to design grating spectrometer for the near infrared requiring single detectors only. Discrete components offer flexibility but also need for adjustment of two mirrors, grating stage, fiber mount and the detector with its slit and optionally a second slit in the entrance area. Further development leads towards the integration of the slits into the MOEMS chip, thus less effort for adjustment. Flexibility might be reduced as adjustments of the optical design or grating spacing would require a new chip with own set of masks. Nevertheless if extreme miniaturization is desired this approach seems to be promising. Besides this, high volume production might be able for a comparable low price. A new chip was developed offering grating, two slits and a cavity for the detector chip. The optical design was adjusted to a planar arrangement of grating and slits. A detector buried in a chip cavity required a new mounting strategy. Other optical components were optimized and fabricated then the systems was assembled with electronics and software adjusted to the new design including some new features like integrated position sensors. A first test of systems to grant function of all components is presented. Further work will be aimed at improved performance like higher resolution and lower SNR.

  2. Summarizing Monte Carlo Results in Methodological Research.

    ERIC Educational Resources Information Center

    Harwell, Michael R.

    1992-01-01

    A methodological framework is provided for quantitatively integrating Type I error rates and power values for Monte Carlo studies. An example is given using Monte Carlo studies of a test of equality of variances, and the importance of relating metanalytic results to exact statistical theory is emphasized. (SLD)

  3. Integrated design and analysis of smart actuators for hybrid assistive knee bracese-fla

    NASA Astrophysics Data System (ADS)

    Guo, H. T.; Liao, W. H.

    2009-03-01

    The objective of this paper is to develop smart actuators for knee braces as assistive devices for helping disabled people to recover their mobility. The actuator functions as motor, clutch, and brake. In the design, magnetorheological (MR) fluids are utilized to generate controllable torque. To decrease the size of the actuator, motor and MR fluids are integrated. MR fluids are filled inside the DC motor based actuator. Additional design factors of smart actuators including influence of permanent magnet on MR fluids and dynamic sealing are also considered. Finite element model of the smart actuator is built and analyzed. A prototype of the smart actuator with two different inner armatures is fabricated and their characteristics are investigated. Torques are compared between simulation and experiments. The results show that the developed smart actuator with multiple functions is promising for assistive knee braces.

  4. Numerical simulation of Stokes flow around particles via a hybrid Finite Difference-Boundary Integral scheme

    NASA Astrophysics Data System (ADS)

    Bhattacharya, Amitabh

    2013-11-01

    An efficient algorithm for simulating Stokes flow around particles is presented here, in which a second order Finite Difference method (FDM) is coupled to a Boundary Integral method (BIM). This method utilizes the strong points of FDM (i.e. localized stencil) and BIM (i.e. accurate representation of particle surface). Specifically, in each iteration, the flow field away from the particles is solved on a Cartesian FDM grid, while the traction on the particle surface (given the the velocity of the particle) is solved using BIM. The two schemes are coupled by matching the solution in an intermediate region between the particle and surrounding fluid. We validate this method by solving for flow around an array of cylinders, and find good agreement with Hasimoto's (J. Fluid Mech. 1959) analytical results.

  5. Integrating heuristic evaluation with cognitive walkthrough: development of a hybrid usability inspection method.

    PubMed

    Kushniruk, Andre W; Monkman, Helen; Tuden, Danica; Bellwood, Paule; Borycki, Elizabeth M

    2015-01-01

    Developing more usable healthcare information systems has become an important goal in health informatics. Although methods from usability engineering have appeared and been effectively applied in the design and evaluation of healthcare systems, there continues to be reports of deployment of unusable systems and issues with adoption of healthcare IT worldwide. In this paper we propose a new cost-effective usability engineering approach for healthcare IT that integrates two of the major usability inspection approaches (heuristic evaluation and cognitive walkthrough) into one combined approach that leverages the advantages of both heuristic evaluation and cognitive walkthrough. The approach will be described as will a pilot application of the method in evaluating the usability of a well-known electronic health record system. Implications and future work will also be described. PMID:25676977

  6. Improving dynamical lattice QCD simulations through integrator tuning using Poisson brackets and a force-gradient integrator

    SciTech Connect

    Clark, M. A.; Joo, Balint; Kennedy, A. D.; Silva, P. J.

    2011-10-01

    We show how the integrators used for the molecular dynamics step of the Hybrid Monte Carlo algorithm can be further improved. These integrators not only approximately conserve some Hamiltonian H but conserve exactly a nearby shadow Hamiltonian H-tilde. This property allows for a new tuning method of the molecular dynamics integrator and also allows for a new class of integrators (force-gradient integrators) which is expected to reduce significantly the computational cost of future large-scale gauge field ensemble generation.

  7. RUN DMC: An Efficient, Parallel Code for Analyzing Radial Velocity Observations Using N-body Integrations and Differential Evolution Markov Chain Monte Carlo

    NASA Astrophysics Data System (ADS)

    Nelson, Benjamin; Ford, Eric B.; Payne, Matthew J.

    2014-01-01

    In the 20+ years of Doppler observations of stars, scientists have uncovered a diverse population of extrasolar multi-planet systems. A common technique for characterizing the orbital elements of these planets is the Markov Chain Monte Carlo (MCMC), using a Keplerian model with random walk proposals and paired with the Metropolis-Hastings algorithm. For approximately a couple of dozen planetary systems with Doppler observations, there are strong planet-planet interactions due to the system being in or near a mean-motion resonance (MMR). An N-body model is often required to accurately describe these systems. Further computational difficulties arise from exploring a high-dimensional parameter space (~7 × number of planets) that can have complex parameter correlations, particularly for systems near a MMR. To surmount these challenges, we introduce a differential evolution MCMC (DEMCMC) algorithm applied to radial velocity data while incorporating self-consistent N-body integrations. Our Radial velocity Using N-body DEMCMC (RUN DMC) algorithm improves upon the random walk proposal distribution of the traditional MCMC by using an ensemble of Markov chains to adaptively improve the proposal distribution. RUN DMC can sample more efficiently from high-dimensional parameter spaces that have strong correlations between model parameters. We describe the methodology behind the algorithm, along with results of tests for accuracy and performance. We find that most algorithm parameters have a modest effect on the rate of convergence. However, the size of the ensemble can have a strong effect on performance. We show that the optimal choice depends on the number of planets in a system, as well as the computer architecture used and the resulting extent of parallelization. While the exact choices of optimal algorithm parameters will inevitably vary due to the details of individual planetary systems (e.g., number of planets, number of observations, orbital periods, and signal-to-noise of each planet), we offer recommendations for choosing the DEMCMC algorithm's algorithmic parameters that result in excellent performance for a wide variety of planetary systems.

  8. Improving the Out-Coupling of a Metal-Metal Terahertz Frequency Quantum Cascade Laser Through Integration of a Hybrid Mode Section into the Waveguide

    NASA Astrophysics Data System (ADS)

    Fobbe, Tobias; Nong, Hanond; Schott, Rüdiger; Pal, Shovon; Markmann, Sergej; Hekmat, Negar; Zhu, Jingxuan; Han, Yingjun; Li, Lianhe; Dean, Paul; Linfield, Edmund H.; Davies, A. Giles; Wieck, Andreas D.; Jukam, Nathan

    2016-05-01

    A hybrid mode section is integrated into the end of the metal-metal waveguide of a terahertz (THz) frequency quantum cascade laser (QCL) by removing sub-wavelength portions of the top metal layer. This allows a hybrid mode to penetrate into the air, which reduces the effective index of the mode and improves the out-coupling performance at the facet. The transmission of the hybrid section is further increased by ensuring its length fulfills the criterion for constructive interference. These simple modifications to a 2.5-THz metal-metal QCL waveguide result in a significant increase in the output emission power. In addition, simulations show that further improvements in out-coupling efficiency can be achieved for lower frequencies with effective refractive indices close to the geometric mean of the indices of the metal-metal waveguide and air.

  9. A hybrid optical switch architecture to integrate IP into optical networks to provide flexible and intelligent bandwidth on demand for cloud computing

    NASA Astrophysics Data System (ADS)

    Yang, Wei; Hall, Trevor J.

    2013-12-01

    The Internet is entering an era of cloud computing to provide more cost effective, eco-friendly and reliable services to consumer and business users. As a consequence, the nature of the Internet traffic has been fundamentally transformed from a pure packet-based pattern to today's predominantly flow-based pattern. Cloud computing has also brought about an unprecedented growth in the Internet traffic. In this paper, a hybrid optical switch architecture is presented to deal with the flow-based Internet traffic, aiming to offer flexible and intelligent bandwidth on demand to improve fiber capacity utilization. The hybrid optical switch is capable of integrating IP into optical networks for cloud-based traffic with predictable performance, for which the delay performance of the electronic module in the hybrid optical switch architecture is evaluated through simulation.

  10. Improving the Out-Coupling of a Metal-Metal Terahertz Frequency Quantum Cascade Laser Through Integration of a Hybrid Mode Section into the Waveguide

    NASA Astrophysics Data System (ADS)

    Fobbe, Tobias; Nong, Hanond; Schott, Rüdiger; Pal, Shovon; Markmann, Sergej; Hekmat, Negar; Zhu, Jingxuan; Han, Yingjun; Li, Lianhe; Dean, Paul; Linfield, Edmund H.; Davies, A. Giles; Wieck, Andreas D.; Jukam, Nathan

    2016-01-01

    A hybrid mode section is integrated into the end of the metal-metal waveguide of a terahertz (THz) frequency quantum cascade laser (QCL) by removing sub-wavelength portions of the top metal layer. This allows a hybrid mode to penetrate into the air, which reduces the effective index of the mode and improves the out-coupling performance at the facet. The transmission of the hybrid section is further increased by ensuring its length fulfills the criterion for constructive interference. These simple modifications to a 2.5-THz metal-metal QCL waveguide result in a significant increase in the output emission power. In addition, simulations show that further improvements in out-coupling efficiency can be achieved for lower frequencies with effective refractive indices close to the geometric mean of the indices of the metal-metal waveguide and air.

  11. Integrating Remote Sensing Data, Hybrid-Cloud Computing, and Event Notifications for Advanced Rapid Imaging & Analysis (Invited)

    NASA Astrophysics Data System (ADS)

    Hua, H.; Owen, S. E.; Yun, S.; Lundgren, P.; Fielding, E. J.; Agram, P.; Manipon, G.; Stough, T. M.; Simons, M.; Rosen, P. A.; Wilson, B. D.; Poland, M. P.; Cervelli, P. F.; Cruz, J.

    2013-12-01

    Space-based geodetic measurement techniques such as Interferometric Synthetic Aperture Radar (InSAR) and Continuous Global Positioning System (CGPS) are now important elements in our toolset for monitoring earthquake-generating faults, volcanic eruptions, hurricane damage, landslides, reservoir subsidence, and other natural and man-made hazards. Geodetic imaging's unique ability to capture surface deformation with high spatial and temporal resolution has revolutionized both earthquake science and volcanology. Continuous monitoring of surface deformation and surface change before, during, and after natural hazards improves decision-making from better forecasts, increased situational awareness, and more informed recovery. However, analyses of InSAR and GPS data sets are currently handcrafted following events and are not generated rapidly and reliably enough for use in operational response to natural disasters. Additionally, the sheer data volumes needed to handle a continuous stream of InSAR data sets also presents a bottleneck. It has been estimated that continuous processing of InSAR coverage of California alone over 3-years would reach PB-scale data volumes. Our Advanced Rapid Imaging and Analysis for Monitoring Hazards (ARIA-MH) science data system enables both science and decision-making communities to monitor areas of interest with derived geodetic data products via seamless data preparation, processing, discovery, and access. We will present our findings on the use of hybrid-cloud computing to improve the timely processing and delivery of geodetic data products, integrating event notifications from USGS to improve the timely processing for response, as well as providing browse results for quick looks with other tools for integrative analysis.

  12. Fabrication of a TFF-Attached WDM-Type Triplex Transceiver Module Using Silica PLC Hybrid Integration Technology

    NASA Astrophysics Data System (ADS)

    Han, Young-Tak; Park, Yoon-Jung; Park, Sang-Ho; Shin, Jang-Uk; Lee, Chul-Wook; Ko, Hyunsung; Baek, Yongsoon; Park, Chul-Hee; Kwon, Yoon-Koo; Hwang, Wol-Yon; Oh, Kwang-Ryong; Sung, Heekyung

    2006-12-01

    An optical triplex transceiver (TRx) module, which consists of thin-film filter (TFF)-attached wavelength-division multiplexer (WDM) and photodiode (PD) carriers, has been fabricated using a silica planar lightwave circuit (PLC) hybrid integration technology. Two types of TFFs were attached to a diced sidewall of a silica-terraced PLC platform to realize the TFF-attached WDM. The PD carriers with a 45 mirror, on which receiving surface-illuminated PDs were bonded, were assembled with the PLC platform to form receiver (Rx) parts. As the main performances of the packaged TRx module, a very clear transmitter (Tx) eye pattern and minimum Rx sensitivity of -25.7 dBm were obtained under a 1.25-Gb/s Tx Rx operation for digital applications. For an analog Rx application, a module responsivity of about 0.8 A/W was achieved, and a second-order intermodulation distortion value of less than -70 dBc at an optical modulation index of 40% was obtained under a two-tone test of 400 and 450 MHz.

  13. A compact frequency-domain photon migration system for integration into commercial hybrid small animal imaging scanners for fluorescence tomography

    PubMed Central

    Darne, Chinmay D.; Lu, Yujie; Tan, I-Chih; Zhu, Banghe; Rasmussen, John C.; Smith, Anne M.; Yan, Shikui; Sevick-Muraca, Eva M

    2012-01-01

    The work presented herein describes system design and performance evaluation of a miniaturized near-infrared fluorescence (NIRF) frequency-domain photon migration (FDPM) system with non-contact excitation and homodyne detection capability for small animal fluorescence tomography. The FDPM system was developed specifically for incorporation into a Siemens microPET/CT commercial scanner for hybrid small animal imaging, but could be adapted to other systems. Operating at 100 MHz, the system noise was minimized and the associated amplitude and phase errors were characterized to be ±0.7% and ±0.3°, respectively. To demonstrate the tomographic ability, a commercial mouse-shaped phantom with 50 μM IRDye800CW and 68Ga containing inclusion was used to associate PET and NIRF tomography. 3-D mesh generation and anatomical referencing was accomplished through CT. A simplified spherical harmonics approximation (SP3) algorithm, for efficient prediction of light propagation in small animals, was tailored to incorporate FDPM approach. Finally, PET-NIRF target co-localization accuracy was analyzed in vivo with a dual-labeled imaging agent targeting orthotopic growth of human prostate cancer. The results obtained validate the integration of time-dependent fluorescence tomography system within a commercial microPET/CT scanner for multimodality small animal imaging. PMID:23171509

  14. Detection of pulmonary nodules in CT images based on fuzzy integrated active contour model and hybrid parametric mixture model.

    PubMed

    Li, Bin; Chen, Kan; Tian, Lianfang; Yeboah, Yao; Ou, Shanxing

    2013-01-01

    The segmentation and detection of various types of nodules in a Computer-aided detection (CAD) system present various challenges, especially when (1) the nodule is connected to a vessel and they have very similar intensities; (2) the nodule with ground-glass opacity (GGO) characteristic possesses typical weak edges and intensity inhomogeneity, and hence it is difficult to define the boundaries. Traditional segmentation methods may cause problems of boundary leakage and "weak" local minima. This paper deals with the above mentioned problems. An improved detection method which combines a fuzzy integrated active contour model (FIACM)-based segmentation method, a segmentation refinement method based on Parametric Mixture Model (PMM) of juxta-vascular nodules, and a knowledge-based C-SVM (Cost-sensitive Support Vector Machines) classifier, is proposed for detecting various types of pulmonary nodules in computerized tomography (CT) images. Our approach has several novel aspects: (1) In the proposed FIACM model, edge and local region information is incorporated. The fuzzy energy is used as the motivation power for the evolution of the active contour. (2) A hybrid PMM Model of juxta-vascular nodules combining appearance and geometric information is constructed for segmentation refinement of juxta-vascular nodules. Experimental results of detection for pulmonary nodules show desirable performances of the proposed method. PMID:23690876

  15. A compact frequency-domain photon migration system for integration into commercial hybrid small animal imaging scanners for fluorescence tomography

    NASA Astrophysics Data System (ADS)

    Darne, Chinmay D.; Lu, Yujie; Tan, I.-Chih; Zhu, Banghe; Rasmussen, John C.; Smith, Anne M.; Yan, Shikui; Sevick-Muraca, Eva M.

    2012-12-01

    The work presented herein describes the system design and performance evaluation of a miniaturized near-infrared fluorescence (NIRF) frequency-domain photon migration (FDPM) system with non-contact excitation and homodyne detection capability for small animal fluorescence tomography. The FDPM system was developed specifically for incorporation into a Siemens micro positron emission tomography/computed tomography (microPET/CT) commercial scanner for hybrid small animal imaging, but could be adapted to other systems. Operating at 100 MHz, the system noise was minimized and the associated amplitude and phase errors were characterized to be ±0.7% and ±0.3°, respectively. To demonstrate the tomographic ability, a commercial mouse-shaped phantom with 50 µM IRDye800CW and 68Ga containing inclusion was used to associate PET and NIRF tomography. Three-dimensional mesh generation and anatomical referencing was accomplished through CT. A third-order simplified spherical harmonics approximation (SP3) algorithm, for efficient prediction of light propagation in small animals, was tailored to incorporate the FDPM approach. Finally, the PET-NIRF target co-localization accuracy was analyzed in vivo with a dual-labeled imaging agent targeting orthotopic growth of human prostate cancer. The obtained results validate the integration of time-dependent fluorescence tomography system within a commercial microPET/CT scanner for multimodality small animal imaging.

  16. A Monte Carlo primer for health physicists.

    PubMed

    Turner, J E; Wright, H A; Hamm, R N

    1985-06-01

    The basic ideas and principles of Monte Carlo calculations are presented in the form of a "primer" for health physicists. A simple integral with a known answer is evaluated by two different Monte Carlo approaches. Random numbers, which underlie Monte Carlo work, are discussed, and a sample table of random numbers generated by a hand calculator is presented. Monte Carlo calculations of dose and linear energy transfer (LET) from 100-keV neutrons incident on a tissue slab are discussed. The random-number table is used in a hand calculation of the initial sequence of events for a 100-keV neutron entering the slab. Some pitfalls in Monte Carlo work are described. While this primer addresses mainly the "bare bones" of Monte Carlo, a final section briefly describes some of the more sophisticated techniques used in practice to reduce variance and computing time. PMID:3997524

  17. Monte Carlo primer for health physicists

    SciTech Connect

    Turner, J.E.; Wright, H.A.; Hamm, R.N.

    1985-06-01

    The basic ideas and principles of Monte Carlo calculations are presented in the form of a primer for health physicists. A simple integral with a known answer is evaluated by two different Monte Carlo approaches. Random number, which underlie Monte Carlo work, are discussed, and a sample table of random numbers generated by a hand calculator is presented. Monte Carlo calculations of dose and linear energy transfer (LET) from 100-keV neutrons incident on a tissue slab are discussed. The random-number table is used in a hand calculation of the initial sequence of events for a 100-keV neutron entering the slab. Some pitfalls in Monte Carlo work are described. While this primer addresses mainly the bare bones of Monte Carlo, a final section briefly describes some of the more sophisticated techniques used in practice to reduce variance and computing time.

  18. A Monte Carlo primer for health physicists.

    TOXLINE Toxicology Bibliographic Information

    Turner JE; Wright HA; Hamm RN

    1985-06-01

    The basic ideas and principles of Monte Carlo calculations are presented in the form of a "primer" for health physicists. A simple integral with a known answer is evaluated by two different Monte Carlo approaches. Random numbers, which underlie Monte Carlo work, are discussed, and a sample table of random numbers generated by a hand calculator is presented. Monte Carlo calculations of dose and linear energy transfer (LET) from 100-keV neutrons incident on a tissue slab are discussed. The random-number table is used in a hand calculation of the initial sequence of events for a 100-keV neutron entering the slab. Some pitfalls in Monte Carlo work are described. While this primer addresses mainly the "bare bones" of Monte Carlo, a final section briefly describes some of the more sophisticated techniques used in practice to reduce variance and computing time.

  19. A Multi-Level Grid Interactive Bi-directional AC/DC-DC/AC Converter and a Hybrid Battery/Ultra-capacitor Energy Storage System with Integrated Magnetics for Plug-in Hybrid Electric Vehicles

    SciTech Connect

    Onar, Omer C

    2011-01-01

    This study presents a bi-directional multi-level power electronic interface for the grid interactions of plug-in hybrid electric vehicles (PHEVs) as well as a novel bi-directional power electronic converter for the combined operation of battery/ultracapacitor hybrid energy storage systems (ESS). The grid interface converter enables beneficial vehicle-to-grid (V2G) interactions in a high power quality and grid friendly manner; i.e, the grid interface converter ensures that all power delivered to/from grid has unity power factor and almost zero current harmonics. The power electronic converter that provides the combined operation of battery/ultra-capacitor system reduces the size and cost of the conventional ESS hybridization topologies while reducing the stress on the battery, prolonging the battery lifetime, and increasing the overall vehicle performance and efficiency. The combination of hybrid ESS is provided through an integrated magnetic structure that reduces the size and cost of the inductors of the ESS converters. Simulation and experimental results are included as prove of the concept presenting the different operation modes of the proposed converters.

  20. An integrated closed-tube 2-plex PCR amplification and hybridization assay with switchable lanthanide luminescence based spatial detection.

    PubMed

    Lahdenper, Susanne; Spangar, Anni; Lempainen, Anna-Maija; Joki, Laura; Soukka, Tero

    2015-06-21

    Switchable lanthanide luminescence is a binary probe technology that inherently enables a high signal modulation in separation-free detection of DNA targets. A luminescent lanthanide complex is formed only when the two probes hybridize adjacently to their target DNA. We have now further adapted this technology for the first time in the integration of a 2-plex polymerase chain reaction (PCR) amplification and hybridization-based solid-phase detection of the amplification products of the Staphylococcus aureus gyrB gene and an internal amplification control (IAC). The assay was performed in a sealed polypropylene PCR chip containing a flat-bottom reaction chamber with two immobilized capture probe spots. The surface of the reaction chamber was functionalized with NHS-PEG-azide and alkyne-modified capture probes for each amplicon, labeled with a light harvesting antenna ligand, and covalently attached as spots to the azide-modified reaction chamber using a copper(i)-catalyzed azide-alkyne cycloaddition. Asymmetric duplex-PCR was then performed with no template, one template or both templates present and with a europium ion carrier chelate labeled probe for each amplicon in the reaction. After amplification europium fluorescence was measured by scanning the reaction chamber as a 10 10 raster with 0.6 mm resolution in time-resolved mode. With this assay we were able to co-amplify and detect the amplification products of the gyrB target from 100, 1000 and 10,000 copies of isolated S. aureus DNA together with the amplification products from the initial 5000 copies of the synthetic IAC template in the same sealed reaction chamber. The addition of 10,000 copies of isolated non-target Escherichia coli DNA in the same reaction with 5000 copies of the synthetic IAC template did not interfere with the amplification or detection of the IAC. The dynamic range of the assay for the synthetic S. aureus gyrB target was three orders of magnitude and the limit of detection of 8 pM was obtained. This proof-of-concept study shows that the switchable lanthanide luminescent probes enable separation-free array-based multiplexed detection of the amplification products in a closed-tube PCR which can enable a higher degree of multiplexing than is currently feasible by using different spectrally separated fluorescent probes. PMID:25882638

  1. Monte Carlo Benchmark

    Energy Science and Technology Software Center (ESTSC)

    2010-10-20

    The "Monte Carlo Benchmark" (MCB) is intended to model the computatiional performance of Monte Carlo algorithms on parallel architectures. It models the solution of a simple heuristic transport equation using a Monte Carlo technique. The MCB employs typical features of Monte Carlo algorithms such as particle creation, particle tracking, tallying particle information, and particle destruction. Particles are also traded among processors using MPI calls.

  2. Discrete Diffusion Monte Carlo for Electron Thermal Transport

    NASA Astrophysics Data System (ADS)

    Chenhall, Jeffrey; Cao, Duc; Wollaeger, Ryan; Moses, Gregory

    2014-10-01

    The iSNB (implicit Schurtz Nicolai Busquet electron thermal transport method of Cao et al. is adapted to a Discrete Diffusion Monte Carlo (DDMC) solution method for eventual inclusion in a hybrid IMC-DDMC (Implicit Monte Carlo) method. The hybrid method will combine the efficiency of a diffusion method in short mean free path regions with the accuracy of a transport method in long mean free path regions. The Monte Carlo nature of the approach allows the algorithm to be massively parallelized. Work to date on the iSNB-DDMC method will be presented. This work was supported by Sandia National Laboratory - Albuquerque.

  3. Modelling personal exposure to particulate air pollution: an assessment of time-integrated activity modelling, Monte Carlo simulation & artificial neural network approaches.

    PubMed

    McCreddin, A; Alam, M S; McNabola, A

    2015-01-01

    An experimental assessment of personal exposure to PM10 in 59 office workers was carried out in Dublin, Ireland. 255 samples of 24-h personal exposure were collected in real time over a 28 month period. A series of modelling techniques were subsequently assessed for their ability to predict 24-h personal exposure to PM10. Artificial neural network modelling, Monte Carlo simulation and time-activity based models were developed and compared. The results of the investigation showed that using the Monte Carlo technique to randomly select concentrations from statistical distributions of exposure concentrations in typical microenvironments encountered by office workers produced the most accurate results, based on 3 statistical measures of model performance. The Monte Carlo simulation technique was also shown to have the greatest potential utility over the other techniques, in terms of predicting personal exposure without the need for further monitoring data. Over the 28 month period only a very weak correlation was found between background air quality and personal exposure measurements, highlighting the need for accurate models of personal exposure in epidemiological studies. PMID:25260856

  4. Desiccant-Based Combined Systems: Integrated Active Desiccant Rooftop Hybrid System Development and Testing Final Report- Phase 4

    SciTech Connect

    Fischer, J

    2005-05-06

    This report summarizes the results of a research and development (R&D) program to design and optimize an active desiccant-vapor compression hybrid rooftop system. The primary objective was to combine the strengths of both technologies to produce a compact, high-performing, energy-efficient system that could accommodate any percentage of outdoor air and deliver essentially any required combination of temperature and humidity, or sensible heat ratio (SHR). In doing so, such a product would address the significant challenges imposed on the performance capabilities of conventional packaged rooftop equipment by standards 62 and 90.1 of the American Society of Heating, Refrigerating and Air-Conditioning Engineers. The body of work completed as part of this program built upon previous R&D efforts supported by the U.S. Department of Energy and summarized by the Phase 3b report ''Active Desiccant Dehumidification Module Integration with Rooftop Packaged HVAC Units'' (Fischer and Sand 2002), in addition to Fischer, Hallstrom, and Sand 2000; Fischer 2000; and Fischer and Sand 2004. All initial design objectives established for this development program were successfully achieved. The performance flexibility desired was accomplished by a down-sized active desiccant wheel that processes only a portion of the supply airflow, which is pre-conditioned by a novel vapor compression cycle. Variable-speed compressors are used to deliver the capacity control required by a system handling a high percentage of outdoor air. An integrated direct digital control system allows for control capabilities not generally offered by conventional packaged rooftop systems. A 3000-cfm prototype system was constructed and tested in the SEMCO engineering test laboratory in Columbia, MO, and was found to operate in an energy-efficient fashion relative to more conventional systems. Most important, the system offered the capability to independently control the supply air temperature and humidity content to provide individual sensible and latent loads required by an occupied space without over-cooling and reheating air. The product was developed using a housing construction similar to that of a conventional packaged rooftop unit. The resulting integrated active desiccant rooftop (IADR) is similar in size to a currently available conventional rooftop unit sized to provide an equivalent total cooling capacity. Unlike a conventional rooftop unit, the IADR can be operated as a dedicated outdoor air system processing 100% outdoor air, as well as a total conditioning system capable of handling any ratio of return air to outdoor air. As part of this R&D program, a detailed investigation compared the first cost and operating cost of the IADR with costs for a conventional packaged approach for an office building located in Jefferson City, MO. The results of this comparison suggest that the IADR approach, once commercialized, could be cost-competitive with existing technology--exhibiting a one-year to two-year payback period--while simultaneously offering improved humidity control, indoor air quality, and energy efficiency.

  5. Monte Carlo Example Programs

    Energy Science and Technology Software Center (ESTSC)

    2006-05-09

    The Monte Carlo example programs VARHATOM and DMCATOM are two small, simple FORTRAN programs that illustrate the use of the Monte Carlo Mathematical technique for calculating the ground state energy of the hydrogen atom.

  6. Integrating Actionable User-defined Faceted Rules into the Hybrid Science Data System for Advanced Rapid Imaging & Analysis

    NASA Astrophysics Data System (ADS)

    Manipon, G. J. M.; Hua, H.; Owen, S. E.; Sacco, G. F.; Agram, P. S.; Moore, A. W.; Yun, S. H.; Fielding, E. J.; Lundgren, P.; Rosen, P. A.; Webb, F.; Liu, Z.; Smith, A. T.; Wilson, B. D.; Simons, M.; Poland, M. P.; Cervelli, P. F.

    2014-12-01

    The Hybrid Science Data System (HySDS) scalably powers the ingestion, metadata extraction, cataloging, high-volume data processing, and publication of the geodetic data products for the Advanced Rapid Imaging & Analysis for Monitoring Hazard (ARIA-MH) project at JPL. HySDS uses a heterogeneous set of worker nodes from private & public clouds as well as virtual & bare-metal machines to perform every aspect of the traditional science data system. For our science data users, the forefront of HySDS is the facet search interface, FacetView, which allows them to browse, filter, and access the published products. Users are able to explore the collection of product metadata information and apply multiple filters to constrain the result set down to their particular interests. It allows them to download these faceted products for further analysis and generation of derived products. However, we have also employed a novel approach to faceting where it is also used to apply constraints for custom monitoring of products, system resources, and triggers for automated data processing. The power of the facet search interface is well documented across various domains and its usefulness is rooted in the current state of existence of metadata. However, user needs usually extend beyond what is currently present in the data system. A user interested in synthetic aperture radar (SAR) data over Kilauea will download them from FacetView but would also want email notification of future incoming scenes. The user may even want that data pushed to a remote workstation for automated processing. Better still, these future products could trigger HySDS to run the user's analysis on its array of worker nodes, on behalf of the user, and ingest the resulting derived products. We will present our findings in integrating an ancillary, user-defined, system-driven processing system for HySDS that allows users to define faceted rules based on facet constraints and triggers actions when new SAR data products arrive that match the constraints. We will discuss use cases where users have defined rules for the automated generation of InSAR derived products: interferograms for California and Kilauea, time-series analyses, and damage proxy maps. These findings are relevant for science data system development of the proposed NASA-ISRO SAR mission.

  7. Dual-facet coupling of SOA array on 4-μm silicon-on-insulator implementing a hybrid integrated SOA-MZI wavelength converter

    NASA Astrophysics Data System (ADS)

    Alexoudi, T.; Fitsios, D.; Kanellos, G. T.; Pleros, N.; Tekin, T.; Cherchi, M.; Ylinen, S.; Harjanne, M.; Kapulainen, M.; Aalto, T.

    2014-03-01

    Hybrid integration on Silicon-on-Insulator (SOI) has emerged as a practical solution for compact and high-performance Photonic Integrated Circuits (PICs). It aims at combining the cost-effectiveness and CMOS-compatibility benefits of the low-loss SOI waveguide platform with the versatile active optical functions that can be realized by III-V photonic materials. The utilization of SOI, as an integration board, with μm-scale dimensions allows for an excellent optical mode matching between silicon rib waveguides and active chips, allowing for minimal-loss coupling of the pre-fabricated IIIV components. While dual-facet coupling as well as III-V multi-element array bonding should be employed to enable enhanced active on-chip functions, so far only single side SOA bonding has been reported. In the present communication, we present a novel integration scheme that flip-chip bonds a 6-SOA array on 4-μm thick SOI technology by coupling both lateral SOA facets to the waveguides, and report on the experimental results of wavelength conversion operation of a dual-element Semiconductor Optical Amplifier - Mach Zehnder Interferometer (SOA-MZI) circuit. Thermocompression bonding was applied to integrate the pre-fabricated SOAs on SOI, with vertical and horizontal alignment performed successfully at both SOA facets. The demonstrated device has a footprint of 8.2mm x 0.3mm and experimental evaluation revealed a 12Gb/s wavelength conversion operation capability with only 0.8dB power penalty for the first SOA-MZI-on-SOI circuit and a 10Gb/s wavelength conversion operation capability with 2 dB power penalty for the second SOA-MZI circuit. Our experiments show how dual facet integration can significantly increase the level of optical functionalities achievable by flip-chip hybrid technology and pave the way for more advanced and more densely PICs.

  8. Hybrid integrated InGaAsP-Si laser using selective area metal bonding method for optical interconnection

    NASA Astrophysics Data System (ADS)

    Yu, Hong-Yan; Yuan, Li-Jun; Tao, Li; Wang, Bao-Jun; Chen, Wei-Xi; Liang, Song; Li, Yan-Ping; Ran, Guang-Zhao; Pan, Jiao-Qing; Wang, Wei

    2014-03-01

    An evanescently-coupled, hybrid InGaAsP-Si laser operating at 1.55 μm is presented by selective area metal bonding (SAMB). The III-V laser, fabricated on a p-InP substrate with a semi-insulating InP:Fe buried heterostructure (BH), serves to provide optical gain. On the SOI wafer, a 3-μm wide and 500-nm high Si waveguide is formed and the bonding metal (AuSn alloy) is selectively deposited in the regions 6 μm away from the Si waveguide on each side. The InGaAsP gain structure is flip-chip bonded onto the patterned SOI wafer using SAMB method which separates laterally the optical coupling area and the metal bonding area to avoid strong light absorption by the bonding metal. The hybrid laser runs with a maximum single-sided output power of 9 mw at room temperature. The slope efficiency of the hybrid laser is about 0.04 W/A, 4 times that of the laser before bonding which indicates that the light confinement is improved after the bonding. The hybrid laser has achieved 10 °C contimuous wave (CW) lasing. A near-field image of the hybrid laser is studied. As the inject current increases, the light spot markedly shifts down to the Si waveguide and covers the Si waveguide region, which demonstrates that the light generated in the III-V active region is coupled into the Si waveguide. This method allows for different III-V devices to be bonded onto any desired places on a SOI substrate. The simplicity and flexibility of the fabrication process and high yield make the hybrid laser a promising light source.

  9. Iterative acceleration methods for Monte Carlo and deterministic criticality calculations

    SciTech Connect

    Urbatsch, T.J.

    1995-11-01

    If you have ever given up on a nuclear criticality calculation and terminated it because it took so long to converge, you might find this thesis of interest. The author develops three methods for improving the fission source convergence in nuclear criticality calculations for physical systems with high dominance ratios for which convergence is slow. The Fission Matrix Acceleration Method and the Fission Diffusion Synthetic Acceleration (FDSA) Method are acceleration methods that speed fission source convergence for both Monte Carlo and deterministic methods. The third method is a hybrid Monte Carlo method that also converges for difficult problems where the unaccelerated Monte Carlo method fails. The author tested the feasibility of all three methods in a test bed consisting of idealized problems. He has successfully accelerated fission source convergence in both deterministic and Monte Carlo criticality calculations. By filtering statistical noise, he has incorporated deterministic attributes into the Monte Carlo calculations in order to speed their source convergence. He has used both the fission matrix and a diffusion approximation to perform unbiased accelerations. The Fission Matrix Acceleration method has been implemented in the production code MCNP and successfully applied to a real problem. When the unaccelerated calculations are unable to converge to the correct solution, they cannot be accelerated in an unbiased fashion. A Hybrid Monte Carlo method weds Monte Carlo and a modified diffusion calculation to overcome these deficiencies. The Hybrid method additionally possesses reduced statistical errors.

  10. Integrated Markov Chain Monte Carlo (MCMC) analysis of primordial non-Gaussianity (f{sub NL}) in the recent CMB data

    SciTech Connect

    Kim, Jaiseung

    2011-04-01

    We have made a Markov Chain Monte Carlo (MCMC) analysis of primordial non-Gaussianity (f{sub NL}) using the WMAP bispectrum and power spectrum. In our analysis, we have simultaneously constrained f{sub NL} and cosmological parameters so that the uncertainties of cosmological parameters can properly propagate into the f{sub NL} estimation. Investigating the parameter likelihoods deduced from MCMC samples, we find slight deviation from Gaussian shape, which makes a Fisher matrix estimation less accurate. Therefore, we have estimated the confidence interval of f{sub NL} by exploring the parameter likelihood without using the Fisher matrix. We find that the best-fit values of our analysis make a good agreement with other results, but the confidence interval is slightly different.

  11. Core-shell hybrid nanogels for integration of optical temperature-sensing, targeted tumor cell imaging, and combined chemo-photothermal treatment.

    PubMed

    Wu, Weitai; Shen, Jing; Banerjee, Probal; Zhou, Shuiqin

    2010-10-01

    We report a class of core-shell structured hybrid nanogels to demonstrate the conception of integrating the functional building blocks into a single nanoparticle system for simultaneously optical temperature-sensing, cancer cell targeting, fluorescence imaging, and combined chemo-photothermal treatment. The hybrid nanogels were constructed by coating the Ag-Au bimetallic NP core with a thermo-responsive nonlinear poly(ethylene glycol) (PEG)-based hydrogel as shell, and semi-interpenetrating the targeting ligands of hyaluronic acid chains into the surface networks of gel shell. The Ag-Au NP core can emit strong visible fluorescence for imaging of mouse melanoma B16F10 cells. The reversible thermo-responsive volume phase transition of the nonlinear PEG-based gel shell cannot only modify the physicochemical environment of the Ag-Au NP core to manipulate the fluorescence intensity for sensing the environmental temperature change, but also provide a high loading capacity for a model anticancer drug temozolomide and offer a thermo-triggered drug release. The drug release can be induced by both the heat generated by external NIR irradiation and the temperature increase of local environmental media. The ability of the hybrid nanogels to combine the local specific chemotherapy with external NIR photothermal treatment significantly improves the therapeutic efficacy due to a synergistic effect. PMID:20643481

  12. A Monte Carlo simulation of ion transport at finite temperatures

    NASA Astrophysics Data System (ADS)

    Ristivojevic, Zoran; Petrović, Zoran Lj

    2012-06-01

    We have developed a Monte Carlo simulation for ion transport in hot background gases, which is an alternative way of solving the corresponding Boltzmann equation that determines the distribution function of ions. We consider the limit of low ion densities when the distribution function of the background gas remains unchanged due to collision with ions. Special attention has been paid to properly treating the thermal motion of the host gas particles and their influence on ions, which is very important at low electric fields, when the mean ion energy is comparable to the thermal energy of the host gas. We found the conditional probability distribution of gas velocities that correspond to an ion of specific velocity which collides with a gas particle. Also, we have derived exact analytical formulae for piecewise calculation of the collision frequency integrals. We address the cases when the background gas is monocomponent and when it is a mixture of different gases. The techniques described here are required for Monte Carlo simulations of ion transport and for hybrid models of non-equilibrium plasmas. The range of energies where it is necessary to apply the technique has been defined. The results we obtained are in excellent agreement with the existing ones obtained by complementary methods. Having verified our algorithm, we were able to produce calculations for Ar+ ions in Ar and propose them as a new benchmark for thermal effects. The developed method is widely applicable for solving the Boltzmann equation that appears in many different contexts in physics.

  13. Kinetic Monte Carlo with fields: diffusion in heterogeneous systems

    NASA Astrophysics Data System (ADS)

    Caro, Jose Alfredo

    2011-03-01

    It is commonly perceived that to achieve breakthrough scientific discoveries in the 21st century an integration of world leading experimental capabilities with theory, computational modeling and high performance computer simulations is necessary. Lying between the atomic and the macro scales, the meso scale is crucial for advancing materials research. Deterministic methods result computationally too heavy to cover length and time scales relevant for this scale. Therefore, stochastic approaches are one of the options of choice. In this talk I will describe recent progress in efficient parallelization schemes for Metropolis and kinetic Monte Carlo [1-2], and the combination of these ideas into a new hybrid Molecular Dynamics-kinetic Monte Carlo algorithm developed to study the basic mechanisms taking place in diffusion in concentrated alloys under the action of chemical and stress fields, incorporating in this way the actual driving force emerging from chemical potential gradients. Applications are shown on precipitation and segregation in nanostructured materials. Work in collaboration with E. Martinez, LANL, and with B. Sadigh, P. Erhart and A. Stukowsky, LLNL. Supported by the Center for Materials at Irradiation and Mechanical Extremes, an Energy Frontier Research Center funded by the U.S. Department of Energy (Award # 2008LANL1026) at Los Alamos National Laboratory

  14. Fiber-wireless integrated mobile backhaul network based on a hybrid millimeter-wave and free-space-optics architecture with an adaptive diversity combining technique.

    PubMed

    Zhang, Junwen; Wang, Jing; Xu, Yuming; Xu, Mu; Lu, Feng; Cheng, Lin; Yu, Jianjun; Chang, Gee-Kung

    2016-05-01

    We propose and experimentally demonstrate a novel fiber-wireless integrated mobile backhaul network based on a hybrid millimeter-wave (MMW) and free-space-optics (FSO) architecture using an adaptive combining technique. Both 60 GHz MMW and FSO links are demonstrated and fully integrated with optical fibers in a scalable and cost-effective backhaul system setup. Joint signal processing with an adaptive diversity combining technique (ADCT) is utilized at the receiver side based on a maximum ratio combining algorithm. Mobile backhaul transportation of 4-Gb/s 16 quadrature amplitude modulation frequency-division multiplexing (QAM-OFDM) data is experimentally demonstrated and tested under various weather conditions synthesized in the lab. Performance improvement in terms of reduced error vector magnitude (EVM) and enhanced link reliability are validated under fog, rain, and turbulence conditions. PMID:27128036

  15. HiRel: Hybrid Automated Reliability Predictor (HARP) integrated reliability tool system, (version 7.0). Volume 1: HARP introduction and user's guide

    NASA Technical Reports Server (NTRS)

    Bavuso, Salvatore J.; Rothmann, Elizabeth; Dugan, Joanne Bechta; Trivedi, Kishor S.; Mittal, Nitin; Boyd, Mark A.; Geist, Robert M.; Smotherman, Mark D.

    1994-01-01

    The Hybrid Automated Reliability Predictor (HARP) integrated Reliability (HiRel) tool system for reliability/availability prediction offers a toolbox of integrated reliability/availability programs that can be used to customize the user's application in a workstation or nonworkstation environment. HiRel consists of interactive graphical input/output programs and four reliability/availability modeling engines that provide analytical and simulative solutions to a wide host of reliable fault-tolerant system architectures and is also applicable to electronic systems in general. The tool system was designed to be compatible with most computing platforms and operating systems, and some programs have been beta tested, within the aerospace community for over 8 years. Volume 1 provides an introduction to the HARP program. Comprehensive information on HARP mathematical models can be found in the references.

  16. Efficient methods for including quantum effects in Monte Carlo calculations of large systems: Extension of the displaced points path integral method and other effective potential methods to calculate properties and distributions

    NASA Astrophysics Data System (ADS)

    Mielke, Steven L.; Dinpajooh, Mohammadhasan; Siepmann, J. Ilja; Truhlar, Donald G.

    2013-01-01

    We present a procedure to calculate ensemble averages, thermodynamic derivatives, and coordinate distributions by effective classical potential methods. In particular, we consider the displaced-points path integral (DPPI) method, which yields exact quantal partition functions and ensemble averages for a harmonic potential and approximate quantal ones for general potentials, and we discuss the implementation of the new procedure in two Monte Carlo simulation codes, one that uses uncorrelated samples to calculate absolute free energies, and another that employs Metropolis sampling to calculate relative free energies. The results of the new DPPI method are compared to those from accurate path integral calculations as well as to results of two other effective classical potential schemes for the case of an isolated water molecule. In addition to the partition function, we consider the heat capacity and expectation values of the energy, the potential energy, the bond angle, and the OH distance. We also consider coordinate distributions. The DPPI scheme performs best among the three effective potential schemes considered and achieves very good accuracy for all of the properties considered. A key advantage of the effective potential schemes is that they display much lower statistical sampling variances than those for accurate path integral calculations. The method presented here shows great promise for including quantum effects in calculations on large systems.

  17. Integration and validation of the physical map of chromosome 21 using a high resolution somatic cell hybrid panel, STS mapping, and rare cleavage

    SciTech Connect

    Patterson, D.; Graw, S.; Gardiner, K.

    1994-09-01

    We are constructing a minimal tiling path of chromosome 21 based on the 810 YAC set described by Chumakov et al., the YACs isolated by the Chromosome 21 Joint YAC Screening Effort, and several additional YAC, cosmid, and P1 libraries. We are integrating the STS and YAC contig data with the high resolution somatic cell hybrid map of chromosome 21 to validate that the YACs chosen as part of the tilling path accurately represent the chromosomal region from which they are derived, to resolve problems of homology between chromosome 21 and other acrocentric chromosomes, to help resolve STS order, to integrate additional markers, especially genes, into the map, and to help in registration of the STS and YAC maps with the cytogenetic and genetic linkage maps. The physical boundaries of 23 different somatic cell hybrids have been determined. This appears to require reordering of some of the STSs on chromosome 21 and suggests the necessity of isolation of additional DNA markers and clones. A remarkable clustering of chromosome 21 breakpoints is observed. Rec-A Assisted Restriction Endonuclease (RARE) cleavage is being used to assess whether YACs accurately reflect this genomic region of origin and to assess the extent of overlap of YACs. This information will aid in the most efficient generation of high quality reagents for sequencing chromosome 21.

  18. Mineralogy of Libya Montes, Mars

    NASA Astrophysics Data System (ADS)

    Perry, K. A.; Bishop, J. L.; McKeown, N. K.

    2009-12-01

    Observations by CRISM (Compact Reconnaissance Imaging Spectrometer for Mars) have revealed a range of minerals in Libya Montes including olivine, pyroxene, and phyllosilicate [1]. Here we extend our spectral analyses of CRISM images in Libya Montes to identify carbonates. We have also performed detailed characterization of the spectral signature of the phyllosilicate- and carbonate-bearing outcrops in order to constrain the types of phyllosilicates and carbonates present. Phyllosilicate-bearing rocks in Libya Montes have spectral bands at 1.42, 2.30 and 2.39 µm, consistent with Fe- and Mg- bearing smectites. The mixture of Fe and Mg in Libya Montes may be within the clay mineral structure or within the CRISM pixel. Because the pixels have 18 meter/pixel spatial resolution, it is possible that the bands observed are due to the mixing of nontronite and saponite rather than a smectite with both Fe and Mg. Carbonates found in Libya Montes are similar to those found in Nili Fossae [2]. The carbonates have bands centered at 2.30 and 2.52 µm. Libya Montes carbonates most closely resemble the Mg-carbonate, magnesite. Olivine spectra are seen throughout Libya Montes, characterized by a positive slope from 1.2-1.8 µm. Large outcrops of olivine are relatively rare on Mars [3]. This implies that fresh bedrock has been recently exposed because olivine weathers readily compared to pyroxene and feldspar. Pyroxene in Libya Montes resembles an Fe-bearing orthopyroxene with a broad band centered at 1.82 µm. The lowermost unit identified in Libya Montes is a clay-bearing unit. Overlying this is a carbonate-bearing unit with a clear unit division visible in at least one CRISM image. An olivine-bearing unit unconformably overlies these two units and may represent a drape related to the Isidis impact, as suggested for Nili Fossae [2]. However, it appears that the carbonate in Libya Montes is an integral portion of the rock underlying the olivine-bearing unit rather than an alteration product, contrasting with proposed stratigraphy for Nili Fossae. The uppermost unit identified is a pyroxene-bearing unit. Some spectra of clays and carbonates in this region present a slope from 1.2 to 1.8 µm similar to olivine. Laboratory experiments were conducted in attempt to understand the relationship of mixtures including olivine, nontronite, and magnesite. The characteristic olivine slope is evident in the spectra in any mixture, even with as little as 10% olivine. In ternary mixtures, the magnesite is almost completely overshadowed by the nontronite and olivine characteristics. The discovery of clays and carbonates in Libya Montes indicates that there was an aqueous environment with neutral pH in the past. In addition, water needs to be relatively still and deep for the small particles to precipitate out and form into the minerals. On Earth, this would be a still lake or deep ocean, and perhaps a similar environment may have been present here in Mars’ past. References [1] Bishop, J. L., et al. (2007) 7th Int'l Mars Conf. [2] Ehlmann, B. L., et al. (2008) Science, 322, 1828. [3] Mustard, J. F., et al. (2008) Nature, 454, 07305.

  19. Direct Comparisons among Fast Off-Lattice Monte Carlo Simulations, Integral Equation Theories, and Gaussian Fluctuation Theory for Disordered Symmetric Diblock Copolymers

    NASA Astrophysics Data System (ADS)

    Yang, Delian; Zong, Jing; Wang, Qiang

    2012-02-01

    Based on the same model system of symmetric diblock copolymers as discrete Gaussian chains with soft, finite-range repulsions as commonly used in dissipative-particle dynamics simulations, we directly compare, without any parameter-fitting, the thermodynamic and structural properties of the disordered phase obtained from fast off-lattice Monte Carlo (FOMC) simulations^1, reference interaction site model (RISM) and polymer reference interaction site model (PRISM) theories, and Gaussian fluctuation theory. The disordered phase ranges from homopolymer melts (i.e., where the Flory-Huggins parameter χ=0) all the way to the order-disorder transition point determined in FOMC simulations, and the compared quantities include the internal energy, entropy, Helmholtz free energy, excess pressure, constant-volume heat capacity, chain/block dimensions, and various structure factors and correlation functions in the system. Our comparisons unambiguously and quantitatively reveal the consequences of various theoretical approximations and the validity of these theories in describing the fluctuations/correlations in disordered diblock copolymers. [1] Q. Wang and Y. Yin, J. Chem. Phys., 130, 104903 (2009).

  20. Shell model Monte Carlo methods

    SciTech Connect

    Koonin, S.E.; Dean, D.J.

    1996-10-01

    We review quantum Monte Carlo methods for dealing with large shell model problems. These methods reduce the imaginary-time many-body evolution operator to a coherent superposition of one-body evolutions in fluctuating one-body fields; resultant path integral is evaluated stochastically. We first discuss the motivation, formalism, and implementation of such Shell Model Monte Carlo methods. There then follows a sampler of results and insights obtained from a number of applications. These include the ground state and thermal properties of pf-shell nuclei, thermal behavior of {gamma}-soft nuclei, and calculation of double beta-decay matrix elements. Finally, prospects for further progress in such calculations are discussed. 87 refs.

  1. Monte Carlo fundamentals

    SciTech Connect

    Brown, F.B.; Sutton, T.M.

    1996-02-01

    This report is composed of the lecture notes from the first half of a 32-hour graduate-level course on Monte Carlo methods offered at KAPL. These notes, prepared by two of the principle developers of KAPL`s RACER Monte Carlo code, cover the fundamental theory, concepts, and practices for Monte Carlo analysis. In particular, a thorough grounding in the basic fundamentals of Monte Carlo methods is presented, including random number generation, random sampling, the Monte Carlo approach to solving transport problems, computational geometry, collision physics, tallies, and eigenvalue calculations. Furthermore, modern computational algorithms for vector and parallel approaches to Monte Carlo calculations are covered in detail, including fundamental parallel and vector concepts, the event-based algorithm, master/slave schemes, parallel scaling laws, and portability issues.

  2. Two in one: switchable ion conductivity and white light emission integrated in an iodoplumbate-based twin chain hybrid crystal.

    PubMed

    Duan, Hai-Bao; Yu, Shan-Shan; Tong, Yuan-Bo; Zhou, Hong; Ren, Xiao-Ming

    2016-03-21

    An iodoplumbate-based hybrid, [C7-Apy][PbI3] (1), where C7-Apy(+) = 1-heptyl-4-aminopyridinium, was prepared using a simple solution process. Three sequential phase transitions occur in the range of 402-443 K. In both the lowest and highest temperature phases, hybrid crystal 1 is composed of discrete [Pb2I6]∞ twin chains surrounded by C7-Apy(+) cations. The connectivity between PbI6 octahedra within a [Pb2I6]∞ twin chain and the arrangement of cations are quite difference between the lowest and highest temperature phases. Hybrid crystal 1 shows switchable ion conductivity due to the structural phase transition and white light emission attributed to the broad band semiconductor emission of the twin chain. The former functionality has potential application in ion conductor devices; the single-phase white light emitter is a useful material in low-cost, easily-made, high-efficiency white light-emitting diodes. PMID:26869454

  3. Multiscale MonteCarlo equilibration: Pure Yang-Mills theory

    SciTech Connect

    Endres, Michael G.; Brower, Richard C.; Orginos, Kostas; Detmold, William; Pochinsky, Andrew V.

    2015-12-29

    In this study, we present a multiscale thermalization algorithm for lattice gauge theory, which enables efficient parallel generation of uncorrelated gauge field configurations. The algorithm combines standard Monte Carlo techniques with ideas drawn from real space renormalization group and multigrid methods. We demonstrate the viability of the algorithm for pure Yang-Mills gauge theory for both heat bath and hybrid Monte Carlo evolution, and show that it ameliorates the problem of topological freezing up to controllable lattice spacing artifacts.

  4. ITS version 5.0 :the integrated TIGER series of coupled electron/Photon monte carlo transport codes with CAD geometry.

    SciTech Connect

    Franke, Brian Claude; Kensek, Ronald Patrick; Laub, Thomas William

    2005-09-01

    ITS is a powerful and user-friendly software package permitting state-of-the-art Monte Carlo solution of linear time-independent coupled electron/photon radiation transport problems, with or without the presence of macroscopic electric and magnetic fields of arbitrary spatial dependence. Our goal has been to simultaneously maximize operational simplicity and physical accuracy. Through a set of preprocessor directives, the user selects one of the many ITS codes. The ease with which the makefile system is applied combines with an input scheme based on order-independent descriptive keywords that makes maximum use of defaults and internal error checking to provide experimentalists and theorists alike with a method for the routine but rigorous solution of sophisticated radiation transport problems. Physical rigor is provided by employing accurate cross sections, sampling distributions, and physical models for describing the production and transport of the electron/photon cascade from 1.0 GeV down to 1.0 keV. The availability of source code permits the more sophisticated user to tailor the codes to specific applications and to extend the capabilities of the codes to more complex applications. Version 5.0, the latest version of ITS, contains (1) improvements to the ITS 3.0 continuous-energy codes, (2) multigroup codes with adjoint transport capabilities, (3) parallel implementations of all ITS codes, (4) a general purpose geometry engine for linking with CAD or other geometry formats, and (5) the Cholla facet geometry library. Moreover, the general user friendliness of the software has been enhanced through increased internal error checking and improved code portability.

  5. Discrete diffusion Monte Carlo for frequency-dependent radiative transfer

    SciTech Connect

    Densmore, Jeffrey D; Kelly, Thompson G; Urbatish, Todd J

    2010-11-17

    Discrete Diffusion Monte Carlo (DDMC) is a technique for increasing the efficiency of Implicit Monte Carlo radiative-transfer simulations. In this paper, we develop an extension of DDMC for frequency-dependent radiative transfer. We base our new DDMC method on a frequency-integrated diffusion equation for frequencies below a specified threshold. Above this threshold we employ standard Monte Carlo. With a frequency-dependent test problem, we confirm the increased efficiency of our new DDMC technique.

  6. MonteCUBES

    SciTech Connect

    Blennow, Mattias

    2010-03-30

    We introduce the software package MonteCUBES, which is designed to easily and effectively perform Markov Chain Monte Carlo simulations for analyzing neutrino oscillation experiments. We discuss the methods used in the software as well as why we believe that it is particularly useful for simulating new physics effects.

  7. Comparison of internal dose estimates obtained using organ-level, voxel S value, and Monte Carlo techniques

    SciTech Connect

    Grimes, Joshua; Celler, Anna

    2014-09-15

    Purpose: The authors’ objective was to compare internal dose estimates obtained using the Organ Level Dose Assessment with Exponential Modeling (OLINDA/EXM) software, the voxel S value technique, and Monte Carlo simulation. Monte Carlo dose estimates were used as the reference standard to assess the impact of patient-specific anatomy on the final dose estimate. Methods: Six patients injected with{sup 99m}Tc-hydrazinonicotinamide-Tyr{sup 3}-octreotide were included in this study. A hybrid planar/SPECT imaging protocol was used to estimate {sup 99m}Tc time-integrated activity coefficients (TIACs) for kidneys, liver, spleen, and tumors. Additionally, TIACs were predicted for {sup 131}I, {sup 177}Lu, and {sup 90}Y assuming the same biological half-lives as the {sup 99m}Tc labeled tracer. The TIACs were used as input for OLINDA/EXM for organ-level dose calculation and voxel level dosimetry was performed using the voxel S value method and Monte Carlo simulation. Dose estimates for {sup 99m}Tc, {sup 131}I, {sup 177}Lu, and {sup 90}Y distributions were evaluated by comparing (i) organ-level S values corresponding to each method, (ii) total tumor and organ doses, (iii) differences in right and left kidney doses, and (iv) voxelized dose distributions calculated by Monte Carlo and the voxel S value technique. Results: The S values for all investigated radionuclides used by OLINDA/EXM and the corresponding patient-specific S values calculated by Monte Carlo agreed within 2.3% on average for self-irradiation, and differed by as much as 105% for cross-organ irradiation. Total organ doses calculated by OLINDA/EXM and the voxel S value technique agreed with Monte Carlo results within approximately ±7%. Differences between right and left kidney doses determined by Monte Carlo were as high as 73%. Comparison of the Monte Carlo and voxel S value dose distributions showed that each method produced similar dose volume histograms with a minimum dose covering 90% of the volume (D90) agreeing within ±3%, on average. Conclusions: Several aspects of OLINDA/EXM dose calculation were compared with patient-specific dose estimates obtained using Monte Carlo. Differences in patient anatomy led to large differences in cross-organ doses. However, total organ doses were still in good agreement since most of the deposited dose is due to self-irradiation. Comparison of voxelized doses calculated by Monte Carlo and the voxel S value technique showed that the 3D dose distributions produced by the respective methods are nearly identical.

  8. Design of energy-efficient MRF-based clutches with defined fail-safe behavior for integration in hybrid powertrains

    NASA Astrophysics Data System (ADS)

    Erbis, Vadim; Hegger, Christian; Güth, Dirk; Maas, Jürgen

    2015-04-01

    Drag losses in the powertrain are a serious deficiency for any energy-efficient application, especially for hybrid electrical vehicles. A promising approach for fulfilling requirements like efficiency, wear, safety and dynamics is the use of an innovative MRF-based clutch design for the transmission of power that is based on magnetorheological fluids (MRF). MRF are smart fluids with the particular characteristics of changing their apparent viscosity significantly under influence of the magnetic field. Their characteristics are fast switching times and a smooth torque control in the powertrain. In this paper, a novel clutch concept is investigated that facilitates the controlled movement of the MRF from an active torque-transmitting region into an inactive region of the shear gap. This concept enables a complete disengagement of the fluid engaging surfaces in a way that viscous drag torque can be eliminated. Therefore, a simulation based design for such MRF-based clutches is used to design the required magnetic excitation systems for enabling a well-defined safety behavior by the fluid control. Based on this approach, an MRF-based clutch is developed in detail which provides a loss-reduced alternative to conventional disengagement devices in the powertrain. The presented MRF-based clutch enables a investigation of different systems in one design by changing the magnetic excitation. Especially, different possibilities for the fail-safe behavior of the MRF-based clutch are considered to ensure a well-defined condition in electrical or hybrid powertrains in case of a system failure.

  9. Rapid screening, in vitro study of metal oxide and polymer hybrids as delivery coatings for improved soft-tissue integration of implants.

    PubMed

    Jarrell, John D; Dolly, Brandon; Morgan, Jeffrey R

    2010-03-01

    Metal-organic chemistry allows for molecular mixing and creation of a range of submicron phase-separated structures from normally brittle metal oxides and flexible polymers with improved bioactivity and delivery properties. In this study, we used a high throughput platform to investigate the influence of organic metal oxide doping of polydimethylsiloxane (PDMS) coatings on cellular bioactivity and controlled release of vanadium compared with titanium oxide coatings without additional PDMS. Metal-organic-derived titanium and or vanadium was doped into PDMS and used to form a coating on the bottom of cell culture microplates in the absence of added water, acids, or bases. These hybrid coatings were rapidly screened to establish how titanium and vanadium concentration influences cell proliferation, adhesion, and morphology. We demonstrate that titanium doping of PDMS can be used to improve cell proliferation and adhesion, and that vanadium doping caused a biphasic dose response in proliferation. A 28-day vanadium and titanium elution study indicated that titanium was not released, but the presence of PDMS in coatings increased delivery rates of vanadium compared with titania coatings without polymer. Hybrid coatings of titanium-doped polymers have potential for improving wound healing dynamics, soft-tissue integration of medical implants, and use as controlled delivery vehicles. PMID:19301265

  10. Novel multifunction-integrated molecular beacon for the amplification detection of DNA hybridization based on primer/template-free isothermal polymerization.

    PubMed

    Dong, Haiyan; Wu, Zai-Sheng; Xu, Jianguo; Ma, Ji; Zhang, Huijuan; Wang, Jie; Shen, Weiyu; Xie, Jingjing; Jia, Lee

    2015-10-15

    Molecular beacon (MB) is widely explored as a signaling probe in powerful biosensing systems, for example, enzyme-assisted strand displacement amplification (SDA)-based system. The existing polymerization-based amplification system is often composed of recognition element, primer, template and fluorescence reporter. To develop a new MB sensing system and simply the signal amplification design, we herein attempted to propose a multifunctional integrated MB (MI-MB) for the polymerization amplification detection of target DNA via introducing a G-rich fragment into the loop of MB without using any exogenous auxiliary oligonucleotide probe. Utilizing only one MI-MB probe, the p53 target gene could trigger the cycles of hybridization/polymerization/displacement, resulting in amplification of the target hybridization event. Thus, the p53 gene can be detected down to 5 10(-10)M with the linear response range from 5 10(-10)M to 4 10(-7)M. Using the MI-MB, we could readily discriminate the point mutation-contained p53 from the wild-type one. As a proof-of-concept study, owing to its simplicity and multifunction, including recognition, replication, amplification and signaling, the MI-MB exhibits the great potential for the development of different biosensors for various biomedical applications, especially, for early cancer diagnosis. PMID:25982726

  11. Hybridization of the Vector Finite Element Method with the Boundary Integral Method for the Solution of Finite Arrays of Cavity-Backed Slot Antennas

    NASA Astrophysics Data System (ADS)

    Polycarpou, A. C.

    2009-10-01

    The vector finite element method (FEM) is hybridized with the boundary integral (BI) method to solve for the radiation characteristics of a cavity-backed slot (CBS) antenna. The hybridization of the two methods is made possible at the aperture of the antenna separating the cavity interior and the half-space exterior region above an infinite conducting ground plane. Having to solve for a finite array of CBS antennas requires an excessive amount of memory, in order to store the system matrix, and considerable CPU time for the solution of the resulting linear system of equations. Increasing the number of array elements results in a non-linear increase in the number of unknowns, thus making the solution of the linear system impossible. In this paper, we adopt array domain decomposition (ADD) and by taking advantage of the repetitive features of the array, we can reduce the memory requirements to a minimum. In addition, we introduce stationary and non-stationary iteration techniques, with or without preconditioning, to solve the system of linear equations in an efficient manner. Singular value decomposition (SVD) is also used in order to further reduce memory requirements and speed-up matrix-vector multiplications that are inherent in either type of iterative techniques. Computational statistics and comparisons between stationary and non-stationary techniques are presented and discussed.

  12. Constructing one-dimensional silver nanowire-doped reduced graphene oxide integrated with CdS nanowire network hybrid structures toward artificial photosynthesis.

    PubMed

    Liu, Siqi; Weng, Bo; Tang, Zi-Rong; Xu, Yi-Jun

    2015-01-21

    A ternary hybrid structure of one-dimensional (1D) silver nanowire-doped reduced graphene oxide (RGO) integrated with a CdS nanowire (NW) network has been fabricated via a simple electrostatic self-assembly method followed by a hydrothermal reduction process. The electrical conductivity of RGO can be significantly enhanced by opening up new conduction channels by bridging the high resistance grain-boundaries (HGBs) with 1D Ag nanowires, which results in a prolonged lifetime of photo-generated charge carriers excited from the CdS NW network, thus making Ag NW-RGO an efficient co-catalyst with the CdS NW network toward artificial photosynthesis. PMID:25273001

  13. Evaluation of /320×240 pixel LEC GaAs Schottky barrier X-ray imaging arrays, hybridized to CMOS readout circuit based on charge integration

    NASA Astrophysics Data System (ADS)

    Irsigler, R.; Andersson, J.; Alverbro, J.; Borglind, J.; Fröjdh, C.; Helander, P.; Manolopoulos, S.; O'Shea, V.; Smith, K.

    1999-09-01

    320×240 pixels GaAs Schottky barrier detector arrays were fabricated, hybridized to silicon readout circuits, and subsequently evaluated. The detector chip was based on semi-insulating LEC GaAs material. The square shaped pixel detector elements were of the Schottky barrier type and had a pitch of 38 μm. The GaAs wafers were thinned down prior to the fabrication of the ohmic back contact. After dicing, the chips were indium bump, flip-chip bonded to CMOS readout circuits based on charge integration, and finally evaluated. A bias voltage between 50 and 100 V was sufficient to operate the detector. Results on I- V characteristics, noise behaviour and response to X-ray radiation are presented. Images of various objects and slit patterns were acquired by using a standard dental imaging X-ray source. The work done was a part of the XIMAGE project financed by the European Community (Brite-Euram).

  14. a Hybrid Volume Integral-Finite Elements Approach for the Simulation of Eddy Current Inspection of Steam Generator Tubes in the Region of Quadrifoiled Support Plate

    NASA Astrophysics Data System (ADS)

    Skarlatos, A.; Gilles-Pascaud, C.; Pichenot, G.; Cattiaux, G.; Sollier, T.

    2010-02-01

    A hybrid Volume Integral Method (VIM)—Finite Elements Method (FEM) model for the numerical modeling of eddy current inspection of steam generator (SG) tubes near quadrifoiled tube support plates (TSP) is presented. The coupled approach combines the flexibility of the FEM in modeling complex geometries with the numerical efficiency of the VIM, reducing the computational time demanded for the solution of the problem. Material deposit in the TSP openings, responsible for clogging up effects, can also be taken into account with this approach and will be considered in a next stage. The present work is conducted in the context of the further development of the CIVA nondestructive evaluation simulation platform, notably within the undertaken developments concerning coupled FEM-VIM calculations.

  15. Constructing one-dimensional silver nanowire-doped reduced graphene oxide integrated with CdS nanowire network hybrid structures toward artificial photosynthesis

    NASA Astrophysics Data System (ADS)

    Liu, Siqi; Weng, Bo; Tang, Zi-Rong; Xu, Yi-Jun

    2014-12-01

    A ternary hybrid structure of one-dimensional (1D) silver nanowire-doped reduced graphene oxide (RGO) integrated with a CdS nanowire (NW) network has been fabricated via a simple electrostatic self-assembly method followed by a hydrothermal reduction process. The electrical conductivity of RGO can be significantly enhanced by opening up new conduction channels by bridging the high resistance grain-boundaries (HGBs) with 1D Ag nanowires, which results in a prolonged lifetime of photo-generated charge carriers excited from the CdS NW network, thus making Ag NW-RGO an efficient co-catalyst with the CdS NW network toward artificial photosynthesis.A ternary hybrid structure of one-dimensional (1D) silver nanowire-doped reduced graphene oxide (RGO) integrated with a CdS nanowire (NW) network has been fabricated via a simple electrostatic self-assembly method followed by a hydrothermal reduction process. The electrical conductivity of RGO can be significantly enhanced by opening up new conduction channels by bridging the high resistance grain-boundaries (HGBs) with 1D Ag nanowires, which results in a prolonged lifetime of photo-generated charge carriers excited from the CdS NW network, thus making Ag NW-RGO an efficient co-catalyst with the CdS NW network toward artificial photosynthesis. Electronic supplementary information (ESI) available: Experimental details, photographs of the experimental setups for photocatalytic activity testing, SEM images of Ag NWs and CdS NWs, Zeta potential, Raman spectra, DRS spectra, PL spectra and PL decay time evolution, and photocatalytic performances of samples for reduction of 4-NA and recycling test. See DOI: 10.1039/c4nr04229h

  16. Hybrid robust model based on an improved functional link neural network integrating with partial least square (IFLNN-PLS) and its application to predicting key process variables.

    PubMed

    He, Yan-Lin; Xu, Yuan; Geng, Zhi-Qiang; Zhu, Qun-Xiong

    2016-03-01

    In this paper, a hybrid robust model based on an improved functional link neural network integrating with partial least square (IFLNN-PLS) is proposed. Firstly, an improved functional link neural network with small norm of expanded weights and high input-output correlation (SNEWHIOC-FLNN) was proposed for enhancing the generalization performance of FLNN. Unlike the traditional FLNN, the expanded variables of the original inputs are not directly used as the inputs in the proposed SNEWHIOC-FLNN model. The original inputs are attached to some small norm of expanded weights. As a result, the correlation coefficient between some of the expanded variables and the outputs is enhanced. The larger the correlation coefficient is, the more relevant the expanded variables tend to be. In the end, the expanded variables with larger correlation coefficient are selected as the inputs to improve the performance of the traditional FLNN. In order to test the proposed SNEWHIOC-FLNN model, three UCI (University of California, Irvine) regression datasets named Housing, Concrete Compressive Strength (CCS), and Yacht Hydro Dynamics (YHD) are selected. Then a hybrid model based on the improved FLNN integrating with partial least square (IFLNN-PLS) was built. In IFLNN-PLS model, the connection weights are calculated using the partial least square method but not the error back propagation algorithm. Lastly, IFLNN-PLS was developed as an intelligent measurement model for accurately predicting the key variables in the Purified Terephthalic Acid (PTA) process and the High Density Polyethylene (HDPE) process. Simulation results illustrated that the IFLNN-PLS could significant improve the prediction performance. PMID:26685746

  17. Investigation of ion toroidal rotation induced by Lower Hybrid waves in Alcator C-Mod using integrated numerical codes

    NASA Astrophysics Data System (ADS)

    Lee, Jungpyo; Wright, John; Bonoli, Paul; Parker, Ron; Catto, Peter; Podpaly, Yuri; Rice, John; Reinke, Matt; Parra, Felix

    2010-11-01

    Ion toroidal rotation in the counter current direction has been measured in C-Mod during lower hybrid (LH) RF power injection. Toroidal momentum input from the LH waves determines the initial increase of the counter current ion toroidal rotation. Due to the fast build up time of the plateau (< 1msec), the electron distribution function is assumed to be in steady state. We calculate the toroidal momentum input of LH wave to electrons by iterating a full wave code (TORIC-LH) with a Fokker Plank code (CQL3D) to obtain a self consistent steady state electron distribution function. On the longer time scale, comparable to the transport time (˜100msec), ion rotation is changing due to the constant momentum transfer from electrons to ions and the radial flux of ion toroidal momentum by Reynolds stress and collisional viscosity. We suggest a way to evaluate the viscosity terms for the low flow level rotation bya modifielectrostatic gyrokinetic code.

  18. Architecture based on the integration of intermolecular G-quadruplex structure with sticky-end pairing and colorimetric detection of DNA hybridization

    NASA Astrophysics Data System (ADS)

    Li, Hongbo; Wu, Zai-Sheng; Shen, Zhifa; Shen, Guoli; Yu, Ruqin

    2014-01-01

    An interesting discovery is reported in that G-rich hairpin-based recognition probes can self-assemble into a nano-architecture based on the integration of an intermolecular G-quadruplex structure with the sticky-end pairing effect in the presence of target DNAs. Moreover, GNPs modified with partly complementary DNAs can intensively aggregate by hybridization-based intercalation between intermolecular G-quadruplexes, indicating an inspiring assembly mechanism and a powerful colorimetric DNA detection. The proposed intermolecular G-quadruplex-integrated sticky-end pairing assembly (called GISA)-based colorimetric system allows a specific and quantitative assay of p53 DNA with a linear range of more than two orders of magnitude and a detection limit of 0.2 nM, suggesting a considerably improved analytical performance. And more to the point, the discrimination of single-base mismatched target DNAs can be easily conducted via visual observation. The successful development of the present colorimetric system, especially the GISA-based aggregation mechanism of GNPs is different from traditional approaches, and offers a critical insight into the dependence of the GNP aggregation on the structural properties of oligonucleotides, opening a good way to design colorimetric sensing probes and DNA nanostructure. An interesting discovery is reported in that G-rich hairpin-based recognition probes can self-assemble into a nano-architecture based on the integration of an intermolecular G-quadruplex structure with the sticky-end pairing effect in the presence of target DNAs. Moreover, GNPs modified with partly complementary DNAs can intensively aggregate by hybridization-based intercalation between intermolecular G-quadruplexes, indicating an inspiring assembly mechanism and a powerful colorimetric DNA detection. The proposed intermolecular G-quadruplex-integrated sticky-end pairing assembly (called GISA)-based colorimetric system allows a specific and quantitative assay of p53 DNA with a linear range of more than two orders of magnitude and a detection limit of 0.2 nM, suggesting a considerably improved analytical performance. And more to the point, the discrimination of single-base mismatched target DNAs can be easily conducted via visual observation. The successful development of the present colorimetric system, especially the GISA-based aggregation mechanism of GNPs is different from traditional approaches, and offers a critical insight into the dependence of the GNP aggregation on the structural properties of oligonucleotides, opening a good way to design colorimetric sensing probes and DNA nanostructure. Electronic supplementary information (ESI) available: Experimental section, supplementary Figures and perspectives. See DOI: 10.1039/c3nr03547f

  19. MORSE Monte Carlo code

    SciTech Connect

    Cramer, S.N.

    1984-01-01

    The MORSE code is a large general-use multigroup Monte Carlo code system. Although no claims can be made regarding its superiority in either theoretical details or Monte Carlo techniques, MORSE has been, since its inception at ORNL in the late 1960s, the most widely used Monte Carlo radiation transport code. The principal reason for this popularity is that MORSE is relatively easy to use, independent of any installation or distribution center, and it can be easily customized to fit almost any specific need. Features of the MORSE code are described.

  20. Integrating Emerging Topics through Online Team Design in a Hybrid Communication Networks Course: Interaction Patterns and Impact of Prior Knowledge

    ERIC Educational Resources Information Center

    Reisslein, Jana; Seeling, Patrick; Reisslein, Martin

    2005-01-01

    An important challenge in the introductory communication networks course in electrical and computer engineering curricula is to integrate emerging topics, such as wireless Internet access and network security, into the already content-intensive course. At the same time it is essential to provide students with experiences in online collaboration,…

  1. Integrating Emerging Topics through Online Team Design in a Hybrid Communication Networks Course: Interaction Patterns and Impact of Prior Knowledge

    ERIC Educational Resources Information Center

    Reisslein, Jana; Seeling, Patrick; Reisslein, Martin

    2005-01-01

    An important challenge in the introductory communication networks course in electrical and computer engineering curricula is to integrate emerging topics, such as wireless Internet access and network security, into the already content-intensive course. At the same time it is essential to provide students with experiences in online collaboration,

  2. Correction: Fabrication of high performance flexible micro-supercapacitor arrays with hybrid electrodes of MWNT/V2O5 nanowires integrated with a SnO2 nanowire UV sensor

    NASA Astrophysics Data System (ADS)

    Kim, Daeil; Yun, Junyeong; Lee, Geumbee; Sook Ha, Jeong

    2014-11-01

    Correction for `Fabrication of high performance flexible micro-supercapacitor arrays with hybrid electrodes of MWNT/V2O5 nanowires integrated with a SnO2 nanowire UV sensor' by Daeil Kim et al., Nanoscale, 2014, 6, 12034-12041.

  3. Optical properties of tumor tissues grown on the chorioallantoic membrane of chicken eggs measured with a double integrating sphere and inverse Monte Carlo method in the wavelength range of 350-1000 nm

    NASA Astrophysics Data System (ADS)

    Honda, Norihiro; Kariyama, Yoichiro; Ishii, Takuya; Abe, Chiaki; Inoue, Katsushi; Ishizuka, Masahiro; Tanaka, Tohru; Hazama, Hisanao; Awazu, Kunio

    2013-02-01

    Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) is an attractive method because of the shorter decay time of photosensitivity compared with PDT using other drugs. However, the optimum conditions to perform ALA-PDT, e.g., drug dose, wavelength, and irradiation dose have never been clarified. To evaluate the effectiveness of PDT using ALA and its dependence on drug dose, wavelength, and irradiation dose in the treatment of tumors, the usefulness of a tumor model prepared with tumor cells grown on the chorioallantoic membrane of chicken eggs was studied by measuring the optical properties of the tumor model. The optical properties of tumor model were measured with a double integrating sphere optical setup and inverse Monte Carlo technique in the wavelength range from 350 to 1000 nm. The spectra of absorption and reduced scattering coefficients of the tumor model grown in the chicken eggs were compared with those of the other tumor model grown in mice. The measured optical properties of the tumor model using chicken eggs were similar to those of the tumor model using mice. These results indicate that the tumor model using chicken eggs is a suitable system to investigate the effectiveness of ALA-PDT. This in vivo assay system for tumors has advantages for evaluating antitumor effect of ALA-PDT because of its convenience, rapidity, and inexpensiveness.

  4. Fermentative production of poly (γ-glutamic acid) from renewable carbon source and downstream purification through a continuous membrane-integrated hybrid process.

    PubMed

    Kumar, Ramesh; Pal, Parimal

    2015-02-01

    Experimental investigations were carried out on continuous and direct production of poly-(γ-glutamic acid) in a hybrid reactor system that integrated conventional fermentative production step with membrane-based downstream separation and purification. Novelty of the integrated system lies in high degree of purity, conversion, yield and productivity of poly-(γ-glutamic acid) through elimination of substrate-product inhibitions of traditional batch production system. This new system is compact, flexible, eco-friendly and largely fouling-free ensuring steady and continuous production of poly-(γ-glutamic acid) directly from a renewable carbon source at the rate of 0.91 g/L/h. Cross-flow microfiltration membrane modules ensured almost complete separation and recycle of cells without much fouling problem. Well-screened ultrafiltration membrane module helped to concentrate poly-(γ-glutamic acid) while ensuring recovery and recycle of 96% unconverted carbon source resulting in yield of 0.6g/g along with high product purity. PMID:25484125

  5. HiRel: Hybrid Automated Reliability Predictor (HARP) integrated reliability tool system, (version 7.0). Volume 3: HARP Graphics Oriented (GO) input user's guide

    NASA Technical Reports Server (NTRS)

    Bavuso, Salvatore J.; Rothmann, Elizabeth; Mittal, Nitin; Koppen, Sandra Howell

    1994-01-01

    The Hybrid Automated Reliability Predictor (HARP) integrated Reliability (HiRel) tool system for reliability/availability prediction offers a toolbox of integrated reliability/availability programs that can be used to customize the user's application in a workstation or nonworkstation environment. HiRel consists of interactive graphical input/output programs and four reliability/availability modeling engines that provide analytical and simulative solutions to a wide host of highly reliable fault-tolerant system architectures and is also applicable to electronic systems in general. The tool system was designed at the outset to be compatible with most computing platforms and operating systems, and some programs have been beta tested within the aerospace community for over 8 years. This document is a user's guide for the HiRel graphical preprocessor Graphics Oriented (GO) program. GO is a graphical user interface for the HARP engine that enables the drawing of reliability/availability models on a monitor. A mouse is used to select fault tree gates or Markov graphical symbols from a menu for drawing.

  6. HiRel: Hybrid Automated Reliability Predictor (HARP) integrated reliability tool system, (version 7.0). Volume 4: HARP Output (HARPO) graphics display user's guide

    NASA Technical Reports Server (NTRS)

    Sproles, Darrell W.; Bavuso, Salvatore J.

    1994-01-01

    The Hybrid Automated Reliability Predictor (HARP) integrated Reliability (HiRel) tool system for reliability/availability prediction offers a toolbox of integrated reliability/availability programs that can be used to customize the user's application in a workstation or nonworkstation environment. HiRel consists of interactive graphical input/output programs and four reliability/availability modeling engines that provide analytical and simulative solutions to a wide host of highly reliable fault-tolerant system architectures and is also applicable to electronic systems in general. The tool system was designed at the outset to be compatible with most computing platforms and operating systems and some programs have been beta tested within the aerospace community for over 8 years. This document is a user's guide for the HiRel graphical postprocessor program HARPO (HARP Output). HARPO reads ASCII files generated by HARP. It provides an interactive plotting capability that can be used to display alternate model data for trade-off analyses. File data can also be imported to other commercial software programs.

  7. Hybrid polylingual object model: an efficient and seamless integration of Java and native components on the Dalvik virtual machine.

    PubMed

    Huang, Yukun; Chen, Rong; Wei, Jingbo; Pei, Xilong; Cao, Jing; Prakash Jayaraman, Prem; Ranjan, Rajiv

    2014-01-01

    JNI in the Android platform is often observed with low efficiency and high coding complexity. Although many researchers have investigated the JNI mechanism, few of them solve the efficiency and the complexity problems of JNI in the Android platform simultaneously. In this paper, a hybrid polylingual object (HPO) model is proposed to allow a CAR object being accessed as a Java object and as vice in the Dalvik virtual machine. It is an acceptable substitute for JNI to reuse the CAR-compliant components in Android applications in a seamless and efficient way. The metadata injection mechanism is designed to support the automatic mapping and reflection between CAR objects and Java objects. A prototype virtual machine, called HPO-Dalvik, is implemented by extending the Dalvik virtual machine to support the HPO model. Lifespan management, garbage collection, and data type transformation of HPO objects are also handled in the HPO-Dalvik virtual machine automatically. The experimental result shows that the HPO model outweighs the standard JNI in lower overhead on native side, better executing performance with no JNI bridging code being demanded. PMID:25110745

  8. Scalable integration of Li5FeO4 towards robust, high-performance lithium-ion hybrid capacitors.

    PubMed

    Park, Min-Sik; Lim, Young-Geun; Hwang, Soo Min; Kim, Jung Ho; Kim, Jeom-Soo; Dou, Shi Xue; Cho, Jaephil; Kim, Young-Jun

    2014-11-01

    Lithium-ion hybrid capacitors have attracted great interest due to their high specific energy relative to conventional electrical double-layer capacitors. Nevertheless, the safety issue still remains a drawback for lithium-ion capacitors in practical operational environments because of the use of metallic lithium. Herein, single-phase Li5FeO4 with an antifluorite structure that acts as an alternative lithium source (instead of metallic lithium) is employed and its potential use for lithium-ion capacitors is verified. Abundant Li(+) amounts can be extracted from Li5FeO4 incorporated in the positive electrode and efficiently doped into the negative electrode during the first electrochemical charging. After the first Li(+) extraction, Li(+) does not return to the Li5FeO4 host structure and is steadily involved in the electrochemical reactions of the negative electrode during subsequent cycling. Various electrochemical and structural analyses support its superior characteristics for use as a promising lithium source. This versatile approach can yield a sufficient Li(+)-doping efficiency of >90% and improved safety as a result of the removal of metallic lithium from the cell. PMID:25208971

  9. Hybrid Electrodes by In-Situ Integration of Graphene and Carbon-Nanotubes in Polypyrrole for Supercapacitors.

    PubMed

    Aphale, Ashish; Maisuria, Krushangi; Mahapatra, Manoj K; Santiago, Angela; Singh, Prabhakar; Patra, Prabir

    2015-01-01

    Supercapacitors also known as electrochemical capacitors, that store energy via either Faradaic or non-Faradaic processes, have recently grown popularity mainly because they complement, and can even replace, conventional energy storage systems in variety of applications. Supercapacitor performance can be improved significantly by developing new nanocomposite electrodes which utilizes both the energy storage processes simultaneously. Here we report, fabrication of the freestanding hybrid electrodes, by incorporating graphene and carbon nanotubes (CNT) in pyrrole monomer via its in-situ polymerization. At the scan rate of 5 mV s(-1), the specific capacitance of the polypyrrole-CNT-graphene (PCG) electrode film was 453 F g(-1) with ultrahigh energy and power density of 62.96 W h kg(-1) and 566.66 W kg(-1) respectively, as shown in the Ragone plot. A nanofibrous membrane was electrospun and effectively used as a separator in the supercapacitor. Four supercapacitors were assembled in series to demonstrate the device performance by lighting a 2.2 V LED. PMID:26395922

  10. Hybrid Electrodes by In-Situ Integration of Graphene and Carbon-Nanotubes in Polypyrrole for Supercapacitors

    PubMed Central

    Aphale, Ashish; Maisuria, Krushangi; Mahapatra, Manoj K.; Santiago, Angela; Singh, Prabhakar; Patra, Prabir

    2015-01-01

    Supercapacitors also known as electrochemical capacitors, that store energy via either Faradaic or non-Faradaic processes, have recently grown popularity mainly because they complement, and can even replace, conventional energy storage systems in variety of applications. Supercapacitor performance can be improved significantly by developing new nanocomposite electrodes which utilizes both the energy storage processes simultaneously. Here we report, fabrication of the freestanding hybrid electrodes, by incorporating graphene and carbon nanotubes (CNT) in pyrrole monomer via its in-situ polymerization. At the scan rate of 5 mV s−1, the specific capacitance of the polypyrrole-CNT-graphene (PCG) electrode film was 453 F g−1 with ultrahigh energy and power density of 62.96 W h kg−1 and 566.66 W kg−1 respectively, as shown in the Ragone plot. A nanofibrous membrane was electrospun and effectively used as a separator in the supercapacitor. Four supercapacitors were assembled in series to demonstrate the device performance by lighting a 2.2 V LED. PMID:26395922

  11. Electromagnetic scattering from cylindrical objects above a conductive surface using a hybrid finite-element-surface integral equation method.

    PubMed

    Alavikia, Babak; Ramahi, Omar M

    2011-12-01

    This work presents a novel finite-element solution to the problem of scattering from a finite and an infinite array of cylindrical objects with arbitrary shapes and materials over perfectly conducting ground planes. The formulation is based on using the surface integral equation with Green's function of the first or second kind as a boundary constraint. The solution region is divided into interior regions containing the cylindrical objects and the region exterior to all the objects. The finite-element formulation is applied inside the interior regions to derive a linear system of equations associated with nodal field values. Using two-boundary formulation, the surface integral equation is then applied at the truncation boundary as a boundary constraint to connect nodes on the boundaries to interior nodes. The technique presented here is highly efficient in terms of computing resources, versatile, and accurate in comparison with previously published methods. The near and far fields are generated for a finite and an infinite array of objects. While the surface integral equation in combination with the finite-element method was applied before to the problem of scattering from objects in free space, the application of the method to the important problem of scattering from objects above infinite flat ground planes is presented here for the first time, to our knowledge. PMID:22193264

  12. On-chip hybrid photonic-plasmonic light concentrator for nanofocusing in an integrated silicon photonics platform.

    PubMed

    Luo, Ye; Chamanzar, Maysamreza; Apuzzo, Aniello; Salas-Montiel, Rafael; Nguyen, Kim Ngoc; Blaize, Sylvain; Adibi, Ali

    2015-02-11

    The enhancement and confinement of electromagnetic radiation to nanometer scale have improved the performances and decreased the dimensions of optical sources and detectors for several applications including spectroscopy, medical applications, and quantum information. Realization of on-chip nanofocusing devices compatible with silicon photonics platform adds a key functionality and provides opportunities for sensing, trapping, on-chip signal processing, and communications. Here, we discuss the design, fabrication, and experimental demonstration of light nanofocusing in a hybrid plasmonic-photonic nanotaper structure. We discuss the physical mechanisms behind the operation of this device, the coupling mechanisms, and how to engineer the energy transfer from a propagating guided mode to a trapped plasmonic mode at the apex of the plasmonic nanotaper with minimal radiation loss. Optical near-field measurements and Fourier modal analysis carried out using a near-field scanning optical microscope (NSOM) show a tight nanofocusing of light in this structure to an extremely small spot of 0.00563(?/(2n(rmax)))(3) confined in 3D and an exquisite power input conversion of 92%. Our experiments also verify the mode selectivity of the device (low transmission of a TM-like input mode and high transmission of a TE-like input mode). A large field concentration factor (FCF) of about 4.9 is estimated from our NSOM measurement with a radius of curvature of about 20 nm at the apex of the nanotaper. The agreement between our theory and experimental results reveals helpful insights about the operation mechanism of the device, the interplay of the modes, and the gradual power transfer to the nanotaper apex. PMID:25562706

  13. Investigation of 40Gb/s WDM multi-casting using a hybrid integrated Mach-Zehnder interferometer

    NASA Astrophysics Data System (ADS)

    Reading-Picopoulos, Dimitri; Penty, Richard V.; White, Ian H.

    2006-10-01

    All-optical multi-casting permits the establishment of high-quality, high-bandwidth point-to-multipoint applications in metropolitan area networks by diffusing an incoming data carrying wavelength onto a number of outgoing wavelengths. With the proliferation of hybrid Wavelength Division Multiplex (WDM)/Optical Time Division Multiplex (OTDM) networks, the ability to perform high-speed broadcasting of OTDM signals at multiple wavelengths will prove an efficient method in the dissemination of information over WDM. Current approaches to WDM multi-casting involve the execution of multiple cycles of optical-electronic-optical conversion, thus necessitating the use of costly high-speed electronics and optoelectronics. All-optical multi-casting would therefore remove such constraints while concurrently providing for a higher level of network transparency thereby improving network management and performance. To date, the issue has most promisingly been addressed through the manipulation of nonlinear phenomena within semiconductor optical amplifiers (SOA). The demonstrations so far however, have exhibited either low conversion efficiency or operating speed constraint or a complicated setup. All-optical Mach-Zehnder interferometer (MZI) approaches are therefore particularly attractive as they are not limited by the aforementioned constraints, while still offering a low switching power requirement at high-speed and a high level of integratability. In this paper we present a detailed model replicating a 40Gb/s experimental setup in order to investigate the operational limit of the MZI when employed in WDM multi-casting. Through simulation we examine the factors determining the constraints imposed on the maximum number of output multi-cast channels that can be achieved using such a device and establish its suitability as a next-generation all-optical multi-caster.

  14. A hybrid feature selection algorithm integrating an extreme learning machine for landslide susceptibility modeling of Mt. Woomyeon, South Korea

    NASA Astrophysics Data System (ADS)

    Vasu, Nikhil N.; Lee, Seung-Rae

    2016-06-01

    An ever-increasing trend of extreme rainfall events in South Korea owing to climate change is causing shallow landslides and debris flows in mountains that cover 70% of the total land area of the nation. These catastrophic, gravity-driven processes cost the government several billion KRW (South Korean Won) in losses in addition to fatalities every year. The most common type of landslide observed is the shallow landslide, which occurs at 1-3 m depth, and may mobilize into more catastrophic flow-type landslides. Hence, to predict potential landslide areas, susceptibility maps are developed in a geographical information system (GIS) environment utilizing available morphological, hydrological, geotechnical, and geological data. Landslide susceptibility models were developed using 163 landslide points and an equal number of nonlandslide points in Mt. Woomyeon, Seoul, and 23 landslide conditioning factors. However, because not all of the factors contribute to the determination of the spatial probability for landslide initiation, and a simple filter or wrapper-based approach is not efficient in identifying all of the relevant features, a feedback-loop-based hybrid algorithm was implemented in conjunction with a learning scheme called an extreme learning machine, which is based on a single-layer, feed-forward network. Validation of the constructed susceptibility model was conducted using a testing set of landslide inventory data through a prediction rate curve. The model selected 13 relevant conditioning factors out of the initial 23; and the resulting susceptibility map shows a success rate of 85% and a prediction rate of 89.45%, indicating a good performance, in contrast to the low success and prediction rate of 69.19% and 56.19%, respectively, as obtained using a wrapper technique.

  15. Integrated Annotation and Analysis of In Situ Hybridization Images Using the ImAnno System: Application to the Ear and Sensory Organs of the Fetal Mouse

    PubMed Central

    Romand, Raymond; Ripp, Raymond; Poidevin, Laetitia; Boeglin, Marcel; Geffers, Lars; Dollé, Pascal; Poch, Olivier

    2015-01-01

    An in situ hybridization (ISH) study was performed on 2000 murine genes representing around 10% of the protein-coding genes present in the mouse genome using data generated by the EURExpress consortium. This study was carried out in 25 tissues of late gestation embryos (E14.5), with a special emphasis on the developing ear and on five distinct developing sensory organs, including the cochlea, the vestibular receptors, the sensory retina, the olfactory organ, and the vibrissae follicles. The results obtained from an analysis of more than 11,000 micrographs have been integrated in a newly developed knowledgebase, called ImAnno. In addition to managing the multilevel micrograph annotations performed by human experts, ImAnno provides public access to various integrated databases and tools. Thus, it facilitates the analysis of complex ISH gene expression patterns, as well as functional annotation and interaction of gene sets. It also provides direct links to human pathways and diseases. Hierarchical clustering of expression patterns in the 25 tissues revealed three main branches corresponding to tissues with common functions and/or embryonic origins. To illustrate the integrative power of ImAnno, we explored the expression, function and disease traits of the sensory epithelia of the five presumptive sensory organs. The study identified 623 genes (out of 2000) concomitantly expressed in the five embryonic epithelia, among which many (∼12%) were involved in human disorders. Finally, various multilevel interaction networks were characterized, highlighting differential functional enrichments of directly or indirectly interacting genes. These analyses exemplify an under-represention of "sensory" functions in the sensory gene set suggests that E14.5 is a pivotal stage between the developmental stage and the functional phase that will be fully reached only after birth. PMID:25706271

  16. Integrated annotation and analysis of in situ hybridization images using the ImAnno system: application to the ear and sensory organs of the fetal mouse.

    PubMed

    Romand, Raymond; Ripp, Raymond; Poidevin, Laetitia; Boeglin, Marcel; Geffers, Lars; Dollé, Pascal; Poch, Olivier

    2015-01-01

    An in situ hybridization (ISH) study was performed on 2000 murine genes representing around 10% of the protein-coding genes present in the mouse genome using data generated by the EURExpress consortium. This study was carried out in 25 tissues of late gestation embryos (E14.5), with a special emphasis on the developing ear and on five distinct developing sensory organs, including the cochlea, the vestibular receptors, the sensory retina, the olfactory organ, and the vibrissae follicles. The results obtained from an analysis of more than 11,000 micrographs have been integrated in a newly developed knowledgebase, called ImAnno. In addition to managing the multilevel micrograph annotations performed by human experts, ImAnno provides public access to various integrated databases and tools. Thus, it facilitates the analysis of complex ISH gene expression patterns, as well as functional annotation and interaction of gene sets. It also provides direct links to human pathways and diseases. Hierarchical clustering of expression patterns in the 25 tissues revealed three main branches corresponding to tissues with common functions and/or embryonic origins. To illustrate the integrative power of ImAnno, we explored the expression, function and disease traits of the sensory epithelia of the five presumptive sensory organs. The study identified 623 genes (out of 2000) concomitantly expressed in the five embryonic epithelia, among which many (∼12%) were involved in human disorders. Finally, various multilevel interaction networks were characterized, highlighting differential functional enrichments of directly or indirectly interacting genes. These analyses exemplify an under-represention of "sensory" functions in the sensory gene set suggests that E14.5 is a pivotal stage between the developmental stage and the functional phase that will be fully reached only after birth. PMID:25706271

  17. A hybrid electron and photon IMRT planning technique that lowers normal tissue integral patient dose using standard hardware

    SciTech Connect

    Rosca, Florin

    2012-06-15

    Purpose: To present a mixed electron and photon IMRT planning technique using electron beams with an energy range of 6-22 MeV and standard hardware that minimizes integral dose to patients for targets as deep as 7.5 cm. Methods: Ten brain cases, two lung, a thyroid, an abdominal, and a parotid case were planned using two planning techniques: a photon-only IMRT (IMRT) versus a mixed modality treatment (E + IMRT) that includes an enface electron beam and a photon IMRT portion that ensures a uniform target coverage. The electron beam is delivered using a regular cutout placed in an electron cone. The electron energy was chosen to provide a good trade-off between minimizing integral dose and generating a uniform, deliverable plan. The authors choose electron energies that cover the deepest part of PTV with the 65%-70% isodose line. The normal tissue integral dose, the dose for ring structures around the PTV, and the volumes of the 75%, 50%, and 25% isosurfaces were used to compare the dose distributions generated by the two planning techniques. Results: The normal tissue integral dose was lowered by about 20% by the E + IMRT plans compared to the photon-only IMRT ones for most studied cases. With the exception of lungs, the dose reduction associated to the E + IMRT plans was more pronounced further away from the target. The average dose ratio delivered to the 0-2 cm and the 2-4 cm ring structures for brain patients for the two planning techniques were 89.6% and 70.8%, respectively. The enhanced dose sparing away from the target for the brain patients can also be observed in the ratio of the 75%, 50%, and 25% isodose line volumes for the two techniques, which decreases from 85.5% to 72.6% and further to 65.1%, respectively. For lungs, the lateral electron beams used in the E + IMRT plans were perpendicular to the mostly anterior/posterior photon beams, generating much more conformal plans. Conclusions: The authors proved that even using the existing electron delivery hardware, a mixed electron/photon planning technique (E + IMRT) can decrease the normal tissue integral dose compared to a photon-only IMRT plan. Different planning approaches can be enabled by the use of an electron beam directed toward organs at risk distal to the target, which are still spared due the rapid dose fall-off of the electron beam. Examples of such cases are the lateral electron beams in the thoracic region that do not irradiate the heart and contralateral lung, electron beams pointed toward kidneys in the abdominal region, or beams treating brain lesions pointed toward the brainstem or optical apparatus. For brain, electron vertex beams can also be used without irradiating the whole body. Since radiation retreatments become more and more common, minimizing the normal tissue integral dose and the dose delivered to tissues surrounding the target, as enabled by E + IMRT type techniques, should receive more attention.

  18. Susceptibility of clinical isolates of Pseudomonas aeruginosa in the Northern Kyushu district of Japan to carbapenem antibiotics, determined by an integrated concentration method: evaluation of the method based on Monte Carlo simulation.

    PubMed

    Nagasawa, Zenzo; Kusaba, Koji; Aoki, Yosuke

    2008-06-01

    In empirical antibacterial therapy, regional surveillance is expected to yield important information for the determination of the class and dosage regimen of antibacterial agents to be used when dealing with infections with organisms such as Pseudomonas aeruginosa, in which strains resistant to antibacterial agents have been increasing. The minimal inhibitory concentrations (MICs) of five carbapenem antibiotics against P. aeruginosa strains isolated in the Northern Kyushu district of Japan between 2005 and 2006 were measured, and 100 strains for which carbapenem MICs were < or =0.5-32 microg/ml were selected. In this study, MIC was measured by two methods, i.e., the common serial twofold dilution method and an integrated concentration method, in which the concentration was changed, in increments of 2 microg/ml, from 2 to 16 microg/ml. The MIC(50)/MIC(90) values for imipenem, meropenem, biapenem, doripenem, and panipenem, respectively, with the former method were 8/16, 4/16, 4/16, 2/8, and 16/16 microg/ml; and the values were 6/10, 4/12, 4/10, 2/6, and 10/16 microg/ml with the latter method. The MIC data obtained with both methods were subjected to pharmacokinetic/pharmacodynamic (PK/PD) analysis with Monte Carlo simulation to calculate the probability of achieving the target of time above MIC (T>MIC) with each carbapenem. The probability of achieving 25% time above the MIC (T>MIC; % of T>MIC for dosing intervals) and 40% T>MIC against P. aeruginosa with any dosage regimen was higher with doripenem than with any other carbapenem tested. When the two sets of MIC data were subjected to PK/PD analysis, the difference between the two methods in the probability of achieving each % T>MIC was small, thus endorsing the validity of the serial twofold dilution method. PMID:18574662

  19. Analytical insights into the partially integrated transport modeling method for hybrid Reynolds averaged Navier-Stokes equations-large eddy simulations of turbulent flows

    NASA Astrophysics Data System (ADS)

    Chaouat, Bruno; Schiestel, Roland

    2012-08-01

    The basis of the partially integrated transport modeling (PITM) method was introduced by Schiestel and Dejoan ["Towards a new partially integrated transport model for coarse grid and unsteady turbulent flow simulations," Theor. Comput. Fluid Dyn. 18, 443 (2005)], 10.1007/s00162-004-0155-z and Chaouat and Schiestel ["A new partially integrated transport model for subgrid-scale stresses and dissipation rate for turbulent developing flows," Phys. Fluids 17, 065106 (2005)], 10.1063/1.1928607. This method provides a continuous approach for hybrid RANS-LES (Reynolds averaged Navier-Stokes equations-large eddy simulations) simulations with seamless coupling between RANS and LES regions. The main ingredient of the method is the new dissipation-rate equation that can be applied as a subfilter scale turbulence model. Then, it becomes easy to convert almost any usual RANS transport model into a subfilter scale model. In particular, the method can be applied to two equation models and to stress transport models as well. In the derivation of the method, the partial integration technique allows to keep a link between the spectral space and the physical space of the resulting model. The physical turbulent processes involving the production, dissipation, and flux transfer of the turbulent energy are introduced in the equations. The present work, after recalling the main building steps of the PITM method, brings further insight into the physical interpretation of the method, its underlying hypotheses and its internal acting mechanisms. In particular, the finiteness of the coefficients used in the dissipation-rate equation is discussed in detail from a theoretical point of view. Then, we consider the analytical example of self-similar turbulent flow for analyzing the dissipation-rate equation. From an analytical solution obtained by Taylor series expansions taking into account the Kovasznay hypothesis for evaluating the transfer term, we compute the functional coefficients c_{{ɛ }_2} and c_{sfs{ɛ }_2} used in RANS and LES methodologies, respectively, and we demonstrate that both coefficients take on finite values when the Reynolds number goes to infinity. Finally, after briefly mentioning some flow illustrations to get a real appraisal of the PITM method in its capabilities to simulate unsteady flows on relatively coarse grids with a sufficient accuracy for engineering computations, we study the coefficient c_{sfs{ɛ }_2} through one chosen example.

  20. TRISO Fuel Performance: Modeling, Integration into Mainstream Design Studies, and Application to a Thorium-fueled Fusion-Fission Hybrid Blanket

    SciTech Connect

    Powers, J J

    2011-11-28

    This study focused on creating a new tristructural isotropic (TRISO) coated particle fuel performance model and demonstrating the integration of this model into an existing system of neutronics and heat transfer codes, creating a user-friendly option for including fuel performance analysis within system design optimization and system-level trade-off studies. The end product enables both a deeper understanding and better overall system performance of nuclear energy systems limited or greatly impacted by TRISO fuel performance. A thorium-fueled hybrid fusion-fission Laser Inertial Fusion Energy (LIFE) blanket design was used for illustrating the application of this new capability and demonstrated both the importance of integrating fuel performance calculations into mainstream design studies and the impact that this new integrated analysis had on system-level design decisions. A new TRISO fuel performance model named TRIUNE was developed and verified and validated during this work with a novel methodology established for simulating the actual lifetime of a TRISO particle during repeated passes through a pebble bed. In addition, integrated self-consistent calculations were performed for neutronics depletion analysis, heat transfer calculations, and then fuel performance modeling for a full parametric study that encompassed over 80 different design options that went through all three phases of analysis. Lastly, side studies were performed that included a comparison of thorium and depleted uranium (DU) LIFE blankets as well as some uncertainty quantification work to help guide future experimental work by assessing what material properties in TRISO fuel performance modeling are most in need of improvement. A recommended thorium-fueled hybrid LIFE engine design was identified with an initial fuel load of 20MT of thorium, 15% TRISO packing within the graphite fuel pebbles, and a 20cm neutron multiplier layer with beryllium pebbles in flibe molten salt coolant. It operated at a system power level of 2000 MW{sub th}, took about 3.5 years to reach full plateau power, and was capable of an End of Plateau burnup of 38.7 %FIMA if considering just the neutronic constraints in the system design; however, fuel performance constraints led to a maximum credible burnup of 12.1 %FIMA due to a combination of internal gas pressure and irradiation effects on the TRISO materials (especially PyC) leading to SiC pressure vessel failures. The optimal neutron spectrum for the thorium-fueled blanket options evaluated seemed to favor a hard spectrum (low but non-zero neutron multiplier thicknesses and high TRISO packing fractions) in terms of neutronic performance but the fuel performance constraints demonstrated that a significantly softer spectrum would be needed to decrease the rate of accumulation of fast neutron fluence in order to improve the maximum credible burnup the system could achieve.

  1. Monte Carlo Methods

    NASA Astrophysics Data System (ADS)

    Kalos, M. H.

    2010-01-01

    Computation now plays an essential role in science, especially in theoretical physics. The greater depth of our understanding of physical phenomena and the need to predict the behavior of complex devices demands a level of analysis that purely mathematical methods cannot meet. Monte Carlo methods offer some of the most powerful approaches to computation. They permit a simple transcription of a random process into a computer code. Alternatively, they give the only accurate approach to the many-dimensional problems of theoretical physics. I will describe a number of complementary approaches for Monte Carlo methods in treating diverse systems.

  2. Hybrid flow system integrating a miniaturized optoelectronic detector for on-line dynamic fractionation and fluorometric determination of bioaccessible orthophosphate in soils.

    PubMed

    Fiedoruk, Marta; Cocovi-Solberg, David J; Tymecki, Łukasz; Koncki, Robert; Miró, Manuel

    2015-02-01

    An integrated Sequential Injection (SI)/Flow Injection (FI) system furnished with a miniaturized LED-based fluorometric detector is presented in this work for expedient bioaccessibility tests of orthophosphate in soils. Equipped with a microcolumn of conical shape containing 50 mg of soil, the hybrid flow system was resorted to on-line dynamic leaching and real-time quantification of pools of mobilizable orthophosphate using a bi-directional syringe pump and multiposition valve. The flexibility of the flow manifold was harnessed to explore both bi-directional and uni-directional flow extraction modes with the added degree of freedom of on-line dilution of extracts whenever needed. Bioaccessible orthophosphate was split in three fractions, the so-called NH4Cl fraction containing labile exchangeable phosphates, the alkaline fraction with Fe and Al-bound phosphates and the acidic fraction containing Ca-bound phosphates. The prevailing molybdenum blue photometric detection method is replaced by spectrofluorometric detection based on the ion pair formation between the phosphomolybdate heteropolyacid and rhodamine B with the subsequent quenching of the dye fluorescence. The dedicated optoelectronic detector was integrated in a secondary FI manifold and operated according to the fluorometric paired emitter-detector diode (FPEDD) principle involving two light emitting diodes as fluorescence inductors and one as detector of LED-induced fluorescence. Demonstrated with the analysis of a standard reference material (SRM 2711) and a real agricultural soil, the developed FI/SI fractionation system with FPEDD detection is proven reliable against the standard molybdenum blue method (p>0.05), and useful for investigation of the leaching kinetics of orthophosphate in bioaccessibility tests through in-line recording of the extraction profiles. PMID:25435227

  3. The Integrated Clinical Anatomy Program at Alfaisal University: an innovative model of teaching clinically applied functional anatomy in a hybrid curriculum.

    PubMed

    Yaqinuddin, Ahmed; Ikram, Muhammad Faisal; Zafar, Muhammad; Eldin, Nivin Sharaf; Mazhar, Muhammad Atif; Qazi, Sadia; Shaikh, Aftab Ahmed; Obeidat, Akef; Al-Kattan, Khaled; Ganguly, Paul

    2016-03-01

    Anatomy has historically been a cornerstone in medical education regardless of specialty. It is essential for physicians to be able to perform a variety of tasks, including performing invasive procedures, examining radiological images, performing a physical examination of a patient, etc. Medical students have to be prepared for such tasks, and we can assist this by changing the way that we educate students in medical schools. Thus, newer medical curricula need to be designed according to needs of future physicians. In this report, we describe a unique program called the Integrated Clinical Anatomy Program (ICAP). The ICAP was developed at the College of Medicine of Alfaisal University in the Kingdom of Saudi Arabia. Here, we describe the unique features of this program, including the structure and facilities of the Anatomy Resource Center. The Anatomy Resource Center plays a pivotal role in engaging the students for faculty-directed structured laboratory sessions as well as peer-assisted uniform student-centered learning. The ICAP has shown great promise, as reflected by early results from a nationwide progress test. Students from all years of the Alfaisal University medical school scored significantly higher than the national average on the anatomy and physiology component of the nationwide progress test examination, with P values of 0.0179 and 0.0015, respectively. We believe that the ICAP can be used as a model for teaching clinically applied functional anatomy to medical students in a hybrid curriculum around the world. PMID:26847258

  4. Structure of an E. coli integral membrane sulfurtransferase and its structural transition upon SCN− binding defined by EPR-based hybrid method

    PubMed Central

    Ling, Shenglong; Wang, Wei; Yu, Lu; Peng, Junhui; Cai, Xiaoying; Xiong, Ying; Hayati, Zahra; Zhang, Longhua; Zhang, Zhiyong; Song, Likai; Tian, Changlin

    2016-01-01

    Electron paramagnetic resonance (EPR)-based hybrid experimental and computational approaches were applied to determine the structure of a full-length E. coli integral membrane sulfurtransferase, dimeric YgaP, and its structural and dynamic changes upon ligand binding. The solution NMR structures of the YgaP transmembrane domain (TMD) and cytosolic catalytic rhodanese domain were reported recently, but the tertiary fold of full-length YgaP was not yet available. Here, systematic site-specific EPR analysis defined a helix-loop-helix secondary structure of the YagP-TMD monomers using mobility, accessibility and membrane immersion measurements. The tertiary folds of dimeric YgaP-TMD and full-length YgaP in detergent micelles were determined through inter- and intra-monomer distance mapping and rigid-body computation. Further EPR analysis demonstrated the tight packing of the two YgaP second transmembrane helices upon binding of the catalytic product SCN−, which provides insight into the thiocyanate exportation mechanism of YgaP in the E. coli membrane. PMID:26817826

  5. Mapping protein-protein interactions for the yeast ABC transporter Ycf1p by integrated split-ubiquitin membrane yeast two-hybrid analysis.

    PubMed

    Paumi, Christian M; Menendez, Javier; Arnoldo, Anthony; Engels, Kim; Iyer, Kavitha Ravee; Thaminy, Safia; Georgiev, Oleg; Barral, Yves; Michaelis, Susan; Stagljar, Igor

    2007-04-13

    The ATP binding cassette (ABC) transporters are important in human health and disease and represent the largest family of transmembrane proteins; however, their highly hydrophobic nature complicates the use of standard biochemical approaches to identify interacting proteins. Here, we report the development of a modified version of the split-ubiquitin membrane yeast two-hybrid (MYTH) technology using genomically integrated "bait" constructs, hence the designation iMYTH. We used iMYTH in a library-screening format and identified six potential interacting partners of the yeast ABC transporter Ycf1p. Strains deleted for several of these genes result in arsenite sensitivity similar to a Deltaycf1 strain. Transport assays show that one of these, Tus1p, a guanine nucleotide exchange factor (GEF) for the small GTPase Rho1p, is a Rho1p-dependent-positive regulator of Ycf1p. Our study provides proof of principle that iMYTH is an ideal methodology to identify physiological interactors and regulators of ABC transporters and other yeast transmembrane proteins. PMID:17434123

  6. Structure of an E. coli integral membrane sulfurtransferase and its structural transition upon SCN- binding defined by EPR-based hybrid method

    NASA Astrophysics Data System (ADS)

    Ling, Shenglong; Wang, Wei; Yu, Lu; Peng, Junhui; Cai, Xiaoying; Xiong, Ying; Hayati, Zahra; Zhang, Longhua; Zhang, Zhiyong; Song, Likai; Tian, Changlin

    2016-01-01

    Electron paramagnetic resonance (EPR)-based hybrid experimental and computational approaches were applied to determine the structure of a full-length E. coli integral membrane sulfurtransferase, dimeric YgaP, and its structural and dynamic changes upon ligand binding. The solution NMR structures of the YgaP transmembrane domain (TMD) and cytosolic catalytic rhodanese domain were reported recently, but the tertiary fold of full-length YgaP was not yet available. Here, systematic site-specific EPR analysis defined a helix-loop-helix secondary structure of the YagP-TMD monomers using mobility, accessibility and membrane immersion measurements. The tertiary folds of dimeric YgaP-TMD and full-length YgaP in detergent micelles were determined through inter- and intra-monomer distance mapping and rigid-body computation. Further EPR analysis demonstrated the tight packing of the two YgaP second transmembrane helices upon binding of the catalytic product SCN-, which provides insight into the thiocyanate exportation mechanism of YgaP in the E. coli membrane.

  7. Structure of an E. coli integral membrane sulfurtransferase and its structural transition upon SCN(-) binding defined by EPR-based hybrid method.

    PubMed

    Ling, Shenglong; Wang, Wei; Yu, Lu; Peng, Junhui; Cai, Xiaoying; Xiong, Ying; Hayati, Zahra; Zhang, Longhua; Zhang, Zhiyong; Song, Likai; Tian, Changlin

    2016-01-01

    Electron paramagnetic resonance (EPR)-based hybrid experimental and computational approaches were applied to determine the structure of a full-length E. coli integral membrane sulfurtransferase, dimeric YgaP, and its structural and dynamic changes upon ligand binding. The solution NMR structures of the YgaP transmembrane domain (TMD) and cytosolic catalytic rhodanese domain were reported recently, but the tertiary fold of full-length YgaP was not yet available. Here, systematic site-specific EPR analysis defined a helix-loop-helix secondary structure of the YagP-TMD monomers using mobility, accessibility and membrane immersion measurements. The tertiary folds of dimeric YgaP-TMD and full-length YgaP in detergent micelles were determined through inter- and intra-monomer distance mapping and rigid-body computation. Further EPR analysis demonstrated the tight packing of the two YgaP second transmembrane helices upon binding of the catalytic product SCN(-), which provides insight into the thiocyanate exportation mechanism of YgaP in the E. coli membrane. PMID:26817826

  8. Analytical finite element matrix elements and global matrix assembly for hierarchical 3-D vector basis functions within the hybrid finite element boundary integral method

    NASA Astrophysics Data System (ADS)

    Li, L.; Wang, K.; Li, H.; Eibert, T. F.

    2014-11-01

    A hybrid higher-order finite element boundary integral (FE-BI) technique is discussed where the higher-order FE matrix elements are computed by a fully analytical procedure and where the gobal matrix assembly is organized by a self-identifying procedure of the local to global transformation. This assembly procedure applys to both, the FE part as well as the BI part of the algorithm. The geometry is meshed into three-dimensional tetrahedra as finite elements and nearly orthogonal hierarchical basis functions are employed. The boundary conditions are implemented in a strong sense such that the boundary values of the volume basis functions are directly utilized within the BI, either for the tangential electric and magnetic fields or for the asssociated equivalent surface current densities by applying a cross product with the unit surface normals. The self-identified method for the global matrix assembly automatically discerns the global order of the basis functions for generating the matrix elements. Higher order basis functions do need more unknowns for each single FE, however, fewer FEs are needed to achieve the same satisfiable accuracy. This improvement provides a lot more flexibility for meshing and allows the mesh size to raise up to λ/3. The performance of the implemented system is evaluated in terms of computation time, accuracy and memory occupation, where excellent results with respect to precision and computation times of large scale simulations are found.

  9. 2.5-Gb/s hybridly-integrated tunable external cavity laser using a superluminescent diode and a polymer Bragg reflector.

    PubMed

    Yoon, Ki-Hong; Oh, Su Hwan; Kim, Ki Soo; Kwon, O-Kyun; Oh, Dae Kon; Noh, Young-Ouk; Lee, Hyung-Jong

    2010-03-15

    We presented a hybridly-integrated tunable external cavity laser with 0.8 nm mode spacing 16 channels operating in the direct modulation of 2.5-Gbps for a low-cost source of a WDM-PON system. The tunable laser was fabricated by using a superluminescent diode (SLD) and a polymer Bragg reflector. The maximum output power and the power slope efficiency of the tunable laser were 10.3 mW and 0.132 mW/mA, respectively, at the SLD current of 100 mA and the temperature of 25 degrees C. The directly-modulated tunable laser successfully provided 2.5-Gbps transmissions through 20-km standard single mode fiber. The power penalty of the tunable laser was less than 0.8 dB for 16 channels after a 20-km transmission. The power penalty variation was less than 1.4 dB during the blue-shifted wavelength tuning. PMID:20389571

  10. Molecular evidence for hybridization in Colias (Lepidoptera: Pieridae): are Colias hybrids really hybrids?

    PubMed Central

    Dwyer, Heather E; Jasieniuk, Marie; Okada, Miki; Shapiro, Arthur M

    2015-01-01

    Gene flow and hybridization among species dramatically affect our understanding of the species as a biological unit, species relationships, and species adaptations. In North American Colias eurytheme and Colias eriphyle, there has been historical debate over the extent of hybridization occurring and the identity of phenotypically intermediate individuals as genetic hybrids. This study assesses the population structure of these two species to measure the extent of hybridization and the genetic identity of phenotypic intermediates as hybrids. Amplified fragment length polymorphism (AFLP) marker analysis was performed on 378 specimens collected from northern California and Nevada. Population structure was inferred using a Bayesian/Markov chain Monte Carlo method, which probabilistically assigns individuals to genetic clusters. Three genetic clusters provided the best fit for the data. C. eurytheme individuals were primarily assigned to two closely related clusters, and C. eriphyle individuals were mostly assigned to a third, more distantly related cluster. There appeared to be significant hybridization between the two species. Individuals of intermediate phenotype (putative hybrids) were found to be genetically indistinguishable from C. eriphyle, indicating that previous work based on the assumption that these intermediate forms are hybrids may warrant reconsideration. PMID:26306172

  11. High-efficiency single-cell entrapment and fluorescence in situ hybridization analysis using a poly(dimethylsiloxane) microfluidic device integrated with a black poly(ethylene terephthalate) micromesh.

    PubMed

    Matsunaga, Tadashi; Hosokawa, Masahito; Arakaki, Atsushi; Taguchi, Tomoyuki; Mori, Tetsushi; Tanaka, Tsuyoshi; Takeyama, Haruko

    2008-07-01

    Here, we report a high-efficiency single-cell entrapment system with a poly(dimethylsiloxane) (PDMS) microfluidic device integrated with a micromesh, and its application to single-cell fluorescence in situ hybridization (FISH) analysis. A micromesh comprising of 10 x 10 microcavities was fabricated on a black poly(ethylene terephthalate) (PET) substrate by laser ablation. The cavity was approximately 2 microm in diameter. Mammalian cells were driven and trapped onto the microcavities by applying negative pressure. Trapped cells were uniformly arrayed on the micromesh, enabling high-throughput microscopic analysis. Furthermore, we developed a method of PDMS surface modification by using air plasma and the copolymer Pluronic F-127 to prevent nonspecific adsorption on the PDMS microchannel. This method decreased the nonspecific adsorption of cells onto the microchannel to less than 1%. When cells were introduced into the microfluidic device integrated with the black PET micromesh, approximately 70-80% of the introduced cells were successfully trapped. Moreover, for mRNA expression analysis, on-chip fluorescence in situ hybridization (e.g., membrane permeabilization, hybridization, washing) can be performed in a microfluidic assay on an integrated device. This microfluidic device has been employed for the detection of beta-actin mRNA expression in individual Raji cells. Differences in the levels of beta-actin mRNA expression were observed in serum-supplied or serum-starved cell populations. PMID:18537270

  12. Novel Interactome of Saccharomyces cerevisiae Myosin Type II Identified by a Modified Integrated Membrane Yeast Two-Hybrid (iMYTH) Screen

    PubMed Central

    Santiago, Ednalise; Akamine, Pearl; Snider, Jamie; Wong, Victoria; Jessulat, Matthew; Deineko, Viktor; Gagarinova, Alla; Aoki, Hiroyuki; Minic, Zoran; Phanse, Sadhna; San Antonio, Andrea; Cubano, Luis A.; Rymond, Brian C.; Babu, Mohan; Stagljar, Igor; Rodriguez-Medina, Jose R.

    2016-01-01

    Nonmuscle myosin type II (Myo1p) is required for cytokinesis in the budding yeast Saccharomyces cerevisiae. Loss of Myo1p activity has been associated with growth abnormalities and enhanced sensitivity to osmotic stress, making it an appealing antifungal therapeutic target. The Myo1p tail-only domain was previously reported to have functional activity equivalent to the full-length Myo1p whereas the head-only domain did not. Since Myo1p tail-only constructs are biologically active, the tail domain must have additional functions beyond its previously described role in myosin dimerization or trimerization. The identification of new Myo1p-interacting proteins may shed light on the other functions of the Myo1p tail domain. To identify novel Myo1p-interacting proteins, and determine if Myo1p can serve as a scaffold to recruit proteins to the bud neck during cytokinesis, we used the integrated split-ubiquitin membrane yeast two-hybrid (iMYTH) system. Myo1p was iMYTH-tagged at its C-terminus, and screened against both cDNA and genomic prey libraries to identify interacting proteins. Control experiments showed that the Myo1p-bait construct was appropriately expressed, and that the protein colocalized to the yeast bud neck. Thirty novel Myo1p-interacting proteins were identified by iMYTH. Eight proteins were confirmed by coprecipitation (Ape2, Bzz1, Fba1, Pdi1, Rpl5, Tah11, and Trx2) or mass spectrometry (AP-MS) (Abp1). The novel Myo1p-interacting proteins identified come from a range of different processes, including cellular organization and protein synthesis. Actin assembly/disassembly factors such as the SH3 domain protein Bzz1 and the actin-binding protein Abp1 represent likely Myo1p interactions during cytokinesis. PMID:26921299

  13. Novel Interactome of Saccharomyces cerevisiae Myosin Type II Identified by a Modified Integrated Membrane Yeast Two-Hybrid (iMYTH) Screen.

    PubMed

    Santiago, Ednalise; Akamine, Pearl; Snider, Jamie; Wong, Victoria; Jessulat, Matthew; Deineko, Viktor; Gagarinova, Alla; Aoki, Hiroyuki; Minic, Zoran; Phanse, Sadhna; San Antonio, Andrea; Cubano, Luis A; Rymond, Brian C; Babu, Mohan; Stagljar, Igor; Rodriguez-Medina, Jose R

    2016-01-01

    Nonmuscle myosin type II (Myo1p) is required for cytokinesis in the budding yeast Saccharomyces cerevisiae Loss of Myo1p activity has been associated with growth abnormalities and enhanced sensitivity to osmotic stress, making it an appealing antifungal therapeutic target. The Myo1p tail-only domain was previously reported to have functional activity equivalent to the full-length Myo1p whereas the head-only domain did not. Since Myo1p tail-only constructs are biologically active, the tail domain must have additional functions beyond its previously described role in myosin dimerization or trimerization. The identification of new Myo1p-interacting proteins may shed light on the other functions of the Myo1p tail domain. To identify novel Myo1p-interacting proteins, and determine if Myo1p can serve as a scaffold to recruit proteins to the bud neck during cytokinesis, we used the integrated split-ubiquitin membrane yeast two-hybrid (iMYTH) system. Myo1p was iMYTH-tagged at its C-terminus, and screened against both cDNA and genomic prey libraries to identify interacting proteins. Control experiments showed that the Myo1p-bait construct was appropriately expressed, and that the protein colocalized to the yeast bud neck. Thirty novel Myo1p-interacting proteins were identified by iMYTH. Eight proteins were confirmed by coprecipitation (Ape2, Bzz1, Fba1, Pdi1, Rpl5, Tah11, and Trx2) or mass spectrometry (AP-MS) (Abp1). The novel Myo1p-interacting proteins identified come from a range of different processes, including cellular organization and protein synthesis. Actin assembly/disassembly factors such as the SH3 domain protein Bzz1 and the actin-binding protein Abp1 represent likely Myo1p interactions during cytokinesis. PMID:26921299

  14. A robust hybrid model integrating enhanced inputs based extreme learning machine with PLSR (PLSR-EIELM) and its application to intelligent measurement.

    PubMed

    He, Yan-Lin; Geng, Zhi-Qiang; Xu, Yuan; Zhu, Qun-Xiong

    2015-09-01

    In this paper, a robust hybrid model integrating an enhanced inputs based extreme learning machine with the partial least square regression (PLSR-EIELM) was proposed. The proposed PLSR-EIELM model can overcome two main flaws in the extreme learning machine (ELM), i.e. the intractable problem in determining the optimal number of the hidden layer neurons and the over-fitting phenomenon. First, a traditional extreme learning machine (ELM) is selected. Second, a method of randomly assigning is applied to the weights between the input layer and the hidden layer, and then the nonlinear transformation for independent variables can be obtained from the output of the hidden layer neurons. Especially, the original input variables are regarded as enhanced inputs; then the enhanced inputs and the nonlinear transformed variables are tied together as the whole independent variables. In this way, the PLSR can be carried out to identify the PLS components not only from the nonlinear transformed variables but also from the original input variables, which can remove the correlation among the whole independent variables and the expected outputs. Finally, the optimal relationship model of the whole independent variables with the expected outputs can be achieved by using PLSR. Thus, the PLSR-EIELM model is developed. Then the PLSR-EIELM model served as an intelligent measurement tool for the key variables of the Purified Terephthalic Acid (PTA) process and the High Density Polyethylene (HDPE) process. The experimental results show that the predictive accuracy of PLSR-EIELM is stable, which indicate that PLSR-EIELM has good robust character. Moreover, compared with ELM, PLSR, hierarchical ELM (HELM), and PLSR-ELM, PLSR-EIELM can achieve much smaller predicted relative errors in these two applications. PMID:26112928

  15. Improved geometry representations for Monte Carlo radiation transport.

    SciTech Connect

    Martin, Matthew Ryan

    2004-08-01

    ITS (Integrated Tiger Series) permits a state-of-the-art Monte Carlo solution of linear time-integrated coupled electron/photon radiation transport problems with or without the presence of macroscopic electric and magnetic fields of arbitrary spatial dependence. ITS allows designers to predict product performance in radiation environments.

  16. A fully coupled Monte Carlo/discrete ordinates solution to the neutron transport equation. Final report

    SciTech Connect

    Filippone, W.L.; Baker, R.S.

    1990-12-31

    The neutron transport equation is solved by a hybrid method that iteratively couples regions where deterministic (S{sub N}) and stochastic (Monte Carlo) methods are applied. Unlike previous hybrid methods, the Monte Carlo and S{sub N} regions are fully coupled in the sense that no assumption is made about geometrical separation or decoupling. The hybrid method provides a new means of solving problems involving both optically thick and optically thin regions that neither Monte Carlo nor S{sub N} is well suited for by themselves. The fully coupled Monte Carlo/S{sub N} technique consists of defining spatial and/or energy regions of a problem in which either a Monte Carlo calculation or an S{sub N} calculation is to be performed. The Monte Carlo region may comprise the entire spatial region for selected energy groups, or may consist of a rectangular area that is either completely or partially embedded in an arbitrary S{sub N} region. The Monte Carlo and S{sub N} regions are then connected through the common angular boundary fluxes, which are determined iteratively using the response matrix technique, and volumetric sources. The hybrid method has been implemented in the S{sub N} code TWODANT by adding special-purpose Monte Carlo subroutines to calculate the response matrices and volumetric sources, and linkage subrountines to carry out the interface flux iterations. The common angular boundary fluxes are included in the S{sub N} code as interior boundary sources, leaving the logic for the solution of the transport flux unchanged, while, with minor modifications, the diffusion synthetic accelerator remains effective in accelerating S{sub N} calculations. The special-purpose Monte Carlo routines used are essentially analog, with few variance reduction techniques employed. However, the routines have been successfully vectorized, with approximately a factor of five increase in speed over the non-vectorized version.

  17. Nuclear hybrid energy infrastructure

    SciTech Connect

    Agarwal, Vivek; Tawfik, Magdy S.

    2015-02-01

    The nuclear hybrid energy concept is becoming a reality for the US energy infrastructure where combinations of the various potential energy sources (nuclear, wind, solar, biomass, and so on) are integrated in a hybrid energy system. This paper focuses on challenges facing a hybrid system with a Small Modular Reactor at its core. The core of the paper will discuss efforts required to develop supervisory control center that collects data, supports decision-making, and serves as an information hub for supervisory control center. Such a center will also be a model for integrating future technologies and controls. In addition, advanced operations research, thermal cycle analysis, energy conversion analysis, control engineering, and human factors engineering will be part of the supervisory control center. Nuclear hybrid energy infrastructure would allow operators to optimize the cost of energy production by providing appropriate means of integrating different energy sources. The data needs to be stored, processed, analyzed, trended, and projected at right time to right operator to integrate different energy sources.

  18. Dynamic Modeling and Plantwide Control of a Hybrid Power and Chemical Plant: An Integrated Gasification Combined Cycle Coupled with a Methanol Plant

    NASA Astrophysics Data System (ADS)

    Robinson, Patrick J.

    Gasification has been used in industry on a relatively limited scale for many years, but it is emerging as the premier unit operation in the energy and chemical industries. The switch from expensive and insecure petroleum to solid hydrocarbon sources (coal and biomass) is occurring due to the vast amount of domestic solid resources, national security and global warming issues. Gasification (or partial oxidation) is a vital component of "clean coal" technology. Sulfur and nitrogen emissions can be reduced, overall energy efficiency is increased and carbon dioxide recovery and sequestration are facilitated. Gasification units in an electric power generation plant produce a fuel gas for driving combustion turbines. Gasification units in a chemical plant generate synthesis gas, which can be used to produce a wide spectrum of chemical products. Future plants are predicted to be hybrid power/chemical plants with gasification as the key unit operation. The coupling of an Integrated Gasification Combined Cycle (IGCC) with a methanol plant can handle swings in power demand by diverting hydrogen gas from a combustion turbine and synthesis gas from the gasifier to a methanol plant for the production of an easily-stored, hydrogen-consuming liquid product. An additional control degree of freedom is provided with this hybrid plant, fundamentally improving the controllability of the process. The idea is to base-load the gasifier and use the more responsive gas-phase units to handle disturbances. During the summer days, power demand can fluctuate up to 50% over a 12-hour period. The winter provides a different problem where spikes of power demand can go up 15% within the hour. The following dissertation develops a hybrid IGCC / methanol plant model, validates the steady-state results with a National Energy Technical Laboratory study, and tests a proposed control structure to handle these significant disturbances. All modeling was performed in the widely used chemical process simulators Aspen Plus and Aspen Dynamics. This dissertation first presents a simple approximate method for achieving the objective of having a gasifier model that can be exported into Aspen Dynamics. Limitations in the software dealing with solids make this a necessary task. The basic idea is to use a high molecular weight hydrocarbon that is present in the Aspen library as a pseudo fuel. For many plantwide dynamic studies, a rigorous high-fidelity dynamic model of the gasifier is not needed because its dynamics are very fast and the gasifier gas volume is a relatively small fraction of the total volume of the entire plant. The proposed approximate model captures the essential macro-scale thermal, flow, composition and pressure dynamics. This paper does not attempt to optimize the design or control of gasifiers, but merely presents an idea of how to dynamically simulate coal gasification in an approximate way. This dissertation also presents models of the downstream units of a typical IGCC. Dynamic simulations of the H2S absorption/stripping unit, Water-gas Shift (WGS) reactors, and CO2 absorption/stripping unit are essential for the development of stable and agile plantwide control structures of this hybrid power/chemical plant. Due to the high pressure of the system, hydrogen sulfide is removed by means of physical absorption. SELEXOLRTM (a mixture of the dimethyl ethers of polyethylene glycol) is used to achieve a gas purity of less than 5 ppm H2S. This desulfurized synthesis gas is sent to two water gas shift reactors that convert a total of 99% of carbon monoxide to hydrogen. Physical absorption of carbon dioxide with Selexol produces a hydrogen rich stream (90 mol% H2) to be fed into combustion turbines or to a methanol plant. Steady-state economic designs and plantwide control structures are developed in this dissertation. A steady-state economic design, control structure, and successful turndown of the methanol plant are shown in this dissertation. The Plantwide control structure and interaction among units are also shown. The methanol plant was sized to handle a reductions of the power generation from an IGCC by 50%, producing a high purity methanol stream of 99.5 mol%. Advanced regulatory control structures were designed and play a significant role for the successful turndown of the methanol plant to 20% capacity. The cooled methanol reactor is controlled by the exit temperature instead of a peak temperature within the reactor. During times of low capacity and minimum vapor rate within the column, tray temperature is controlled by recycling some of the distillate and bottoms flow. The gasifier feed is held constant. The product hydrogen from the IGCC is fed to the combustion turbine as required by electric power demand. Synthesis gas fed into the methanol plant maintains pressure of the hydrogen stream. Make-up hydrogen is also fed to the methanol plant to maintain stoichiometry via a flow ratio. This ratio is adjusted to hold carbon monoxide composition of the recycle gas in the methanol plant. This dissertation also explores various methods on how to turn down distillation columns to very low capacity. Recycling flow back to the column was determined to be the best method. Inserting Langmuir-Hinshelwood-Hougen-Watson kinetics into Aspen was also demonstrated with an example.

  19. A hybrid fluorous monolithic capillary column with integrated nanoelectrospray ionization emitter for determination of perfluoroalkyl acids by nano-liquid chromatography-nanoelectrospray ionization-mass spectrometry/mass spectrometry.

    PubMed

    Zhang, Haiyang; Ou, Junjie; Wei, Yinmao; Wang, Hongwei; Liu, Zhongshan; Zou, Hanfa

    2016-04-01

    A hybrid fluorous monolithic column was simply prepared via photo-initiated free radical polymerization of an acrylopropyl polyhedral oligomeric silsesquioxane (acryl-POSS) and a perfluorous monomer (2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptyl acrylate) in UV-transparent fused-silica capillaries within 5min. The physical characterization of hybrid fluorous monolith, including scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, mercury intrusion porosimetry (MIP) and nitrogen adsorption/desorption measurement was performed. Chromatographic performance was also evaluated by capillary liquid chromatography (cLC). Due to the fluorous-fluorous interaction between fluorous monolith and analytes, fluorobenzenes could well be separated, and the column efficiencies reached 86,600-92,500plates/m at the velocity of 0.87mm/s for alkylbenzenes and 51,900-76,000plates/m at the velocity of 1.10mm/s for fluorobenzenes. Meanwhile, an approach to integrate nanoelectrospray ionization (ESI) emitter with hybrid fluorous monolithic column was developed for quantitative determination of perfluoroalkyl acids by nanoHPLC-ESI-MS/MS. The integration design could minimize extracolumn volume, thus excluding undesirable peak broadening and improving separation performance. PMID:26916593

  20. Digital simulation of hybrid loop operation in RFI backgrounds.

    NASA Technical Reports Server (NTRS)

    Ziemer, R. E.; Nelson, D. R.

    1972-01-01

    A digital computer model for Monte-Carlo simulation of an imperfect second-order hybrid phase-locked loop (PLL) operating in radio-frequency interference (RFI) and Gaussian noise backgrounds has been developed. Characterization of hybrid loop performance in terms of cycle slipping statistics and phase error variance, through computer simulation, indicates that the hybrid loop has desirable performance characteristics in RFI backgrounds over the conventional PLL or the costas loop.

  1. Flare Hybrids

    NASA Astrophysics Data System (ADS)

    Tomczak, M.; Dubieniecki, P.

    2015-12-01

    On the basis of the Solar Maximum Mission observations, Švestka ( Solar Phys. 121, 399, 1989) introduced a new class of flares, the so-called flare hybrids. When they start, they look like typical compact flares (phase 1), but later on, they look like flares with arcades of magnetic loops (phase 2). We summarize the characteristic features of flare hybrids in soft and hard X-rays as well as in the extreme ultraviolet; these features allow us to distinguish flare hybrids from other flares. In this article, additional energy release or long plasma cooling timescales are suggested as possible causes of phase 2. We estimate the frequency of flare hybrids, and study the magnetic configurations favorable for flare hybrid occurrence. Flare hybrids appear to be quite frequent, and the difference between the lengths of magnetic loops in the two interacting loop systems seem to be a crucial parameter for determining their characteristics.

  2. Three-dimensionally stacked flexible integrated circuit: Amorphous oxide/polymer hybrid complementary inverter using n-type a-In-Ga-Zn-O and p-type poly-(9,9-dioctylfluorene-co-bithiophene) thin-film transistors

    NASA Astrophysics Data System (ADS)

    Nomura, Kenji; Aoki, Takashi; Nakamura, Kiyoshi; Kamiya, Toshio; Nakanishi, Takashi; Hasegawa, Takayuki; Kimura, Mutsumi; Kawase, Takeo; Hirano, Masahiro; Hosono, Hideo

    2010-06-01

    A three-dimensional vertically-stacked flexible integrated circuit is demonstrated based on hybrid complementary inverters made of n-type In-Ga-Zn-O (a-IGZO) amorphous oxide thin-film transistors (TFTs) and p-type poly-(9,9-dioctylfluorene-co-bithiophene) (F8T2) polymer TFTs, where all the fabrication processes were performed at temperatures ≤120 °C. Saturation mobilities of the a-IGZO TFT and the F8T2 TFT are ˜3.2 and ˜1.7×10-3 cm2 V-1 s-1, respectively, from which we chose the appropriate dimensions of the TFTs so as to obtain a good balance for the inverter operation. The maximum voltage gain is ˜67, which is better than those reported for organic/oxide hybrid complementary inverters.

  3. Quantum Monte Carlo calculations for carbon nanotubes

    NASA Astrophysics Data System (ADS)

    Luu, Thomas; Lähde, Timo A.

    2016-04-01

    We show how lattice quantum Monte Carlo can be applied to the electronic properties of carbon nanotubes in the presence of strong electron-electron correlations. We employ the path-integral formalism and use methods developed within the lattice QCD community for our numerical work. Our lattice Hamiltonian is closely related to the hexagonal Hubbard model augmented by a long-range electron-electron interaction. We apply our method to the single-quasiparticle spectrum of the (3,3) armchair nanotube configuration, and consider the effects of strong electron-electron correlations. Our approach is equally applicable to other nanotubes, as well as to other carbon nanostructures. We benchmark our Monte Carlo calculations against the two- and four-site Hubbard models, where a direct numerical solution is feasible.

  4. Integrated, Geothermal-CO2 Storage: An Adaptable, Hybrid, Multi-Stage, Energy-Recovery Approach to Reduce Carbon Intensity and Environmental Risk

    NASA Astrophysics Data System (ADS)

    Buscheck, T. A.; Chen, M.; Lu, C.; Sun, Y.; Hao, Y.; Elliot, T. R.; Celia, M. A.; Bielicki, J. M.

    2012-12-01

    The challenges of mitigating climate change and generating sustainable renewable energy are inseparable and can be addressed by synergistic integration of geothermal energy production with secure geologic CO2 storage (GCS). Pressure buildup can be a limiting factor for GCS and geothermal reservoir operations, due to a number of concerns, including the potential for CO2 leakage and induced seismicity, while pressure depletion can limit geothermal energy recovery. Water-use demands can also be a limiting factor for GCS and geothermal operations, particularly where water resources are already scarce. Economic optimization of geothermal-GCS involves trade-offs of various benefits and risks, along with their associated costs: (1) heat extraction per ton of delivered CO2, (2) permanent CO2 storage, (3) energy recovery per unit well (and working-fluid recirculation) costs, and (4) economic lifetime of a project. We analyze a hybrid, multi-stage approach using both formation brine and injected CO2 as working fluids to attempt to optimize the benefits of sustainable energy production and permanent CO2 storage, while conserving water resources and minimizing environmental risks. We consider a range of well-field patterns and operational schemes. Initially, the fluid production is entirely brine. After CO2 breakthrough, the fraction of CO2 in production, which is called the CO2 "cut", increases with time. Thus, brine is the predominant working fluid for early time, with the contribution of CO2 to heat extraction increasing with CO2 cut (and time). We find that smaller well spacing between CO2 injectors and producers favors earlier CO2 breakthrough and a more rapid rise in CO2 cut, which increases the contribution of recirculated CO2, thereby improving the heat extraction per ton of delivered CO2. On the other hand, larger well spacing increases permanent CO2 storage, energy production per unit well cost, while reducing the thermal drawdown rate, which extends the economic lifetime of a project. For the range of cases considered, we were never able to eliminate the co-production of brine; thus, brine management is likely to be important for reservoir operations, whether or not brine is considered as a candidate working fluid. Future work will address site-specific reservoir conditions and infrastructure factors, such as proximity to potential CO2 sources. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  5. Multiscale Monte Carlo equilibration: Pure Yang-Mills theory

    DOE PAGESBeta

    Endres, Michael G.; Brower, Richard C.; Orginos, Kostas; Detmold, William; Pochinsky, Andrew V.

    2015-12-29

    In this study, we present a multiscale thermalization algorithm for lattice gauge theory, which enables efficient parallel generation of uncorrelated gauge field configurations. The algorithm combines standard Monte Carlo techniques with ideas drawn from real space renormalization group and multigrid methods. We demonstrate the viability of the algorithm for pure Yang-Mills gauge theory for both heat bath and hybrid Monte Carlo evolution, and show that it ameliorates the problem of topological freezing up to controllable lattice spacing artifacts.

  6. MCMini: Monte Carlo on GPGPU

    SciTech Connect

    Marcus, Ryan C.

    2012-07-25

    MCMini is a proof of concept that demonstrates the possibility for Monte Carlo neutron transport using OpenCL with a focus on performance. This implementation, written in C, shows that tracing particles and calculating reactions on a 3D mesh can be done in a highly scalable fashion. These results demonstrate a potential path forward for MCNP or other Monte Carlo codes.

  7. CA15-3 is a useful serum tumor marker for diagnostic integration of hybrid positron emission tomography with integrated computed tomography during follow-up of breast cancer patients

    PubMed Central

    2014-01-01

    Background The aim of this study was to evaluate the value of CA15-3 for the diagnostic integration of molecular imaging findings performed with hybrid positron emission tomography and computed tomography (PETCT) technology. Methods We retrospectively selected 45 patients with a median age of 60 years (range 39–85 years) and a previous history of breast cancer (BC) who had already been treated with surgery and other treatments. Three measurements of CA15-3 were collected within 1 year before PETCT examination, at 6–9 months 3–6 months and 0–3 months before PETCT. The prolonged clinical outcome or imaging follow-up was used to define disease relapse. An increase in tumor marker value was compared with PETCT findings and disease relapse. Sensitivity and specificity for both tests were calculated with respect to clinical outcome. Results Disease relapse was detected in 16 out of 45 BC patients. CA15-3 and PETCT showed 75% sensitivity with a specificity percentage of 76% for CA15-3 and 79% for PETCT. Serum CA15-3 expression levels were significantly higher in BC patients with multiple metastatic sites with hepatic involvement. Analysis of serial CA15-3 serum levels showed an increase in CA15-3 3–6 months before PETCT could identify BC patients at risk for relapse (AUC = 0.81). Moreover, patients receiving anti-hormonal or chemotherapy medications with negative PETCT and positive CA15-3 relapsed after a median time of 158 days compared to patients who were negative for both tests and who were free from disease for at least 1 year. Conclusions Our results showed that serial increases in CA15-3 can be used to predict positive PETCT results in BC patients during follow-up. Increased levels of CA15-3 may be considered an early warning sign in patients needing accurate molecular imaging investigations, as they are at higher risk of recurrence. In cases of elevated levels, multiple lesions or liver involvement may exist. Also, patients receiving chemotherapeutic or anti-hormonal treatment who have negative PETCT scans and increased CA15-3 serum levels should be considered at risk for relapse, because the CA15-3-linked biochemical signal of the presence of a tumor can predict positive metabolic imaging. PMID:24886519

  8. Frost in Charitum Montes

    NASA Technical Reports Server (NTRS)

    2003-01-01

    MGS MOC Release No. MOC2-387, 10 June 2003

    This is a Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) wide angle view of the Charitum Montes, south of Argyre Planitia, in early June 2003. The seasonal south polar frost cap, composed of carbon dioxide, has been retreating southward through this area since spring began a month ago. The bright features toward the bottom of this picture are surfaces covered by frost. The picture is located near 57oS, 43oW. North is at the top, south is at the bottom. Sunlight illuminates the scene from the upper left. The area shown is about 217 km (135 miles) wide.

  9. Application of a New Hybrid Model with Seasonal Auto-Regressive Integrated Moving Average (ARIMA) and Nonlinear Auto-Regressive Neural Network (NARNN) in Forecasting Incidence Cases of HFMD in Shenzhen, China

    PubMed Central

    Tan, Li; Jiang, Hongbo; Wang, Ying; Wei, Sheng; Nie, Shaofa

    2014-01-01

    Background Outbreaks of hand-foot-mouth disease (HFMD) have been reported for many times in Asia during the last decades. This emerging disease has drawn worldwide attention and vigilance. Nowadays, the prevention and control of HFMD has become an imperative issue in China. Early detection and response will be helpful before it happening, using modern information technology during the epidemic. Method In this paper, a hybrid model combining seasonal auto-regressive integrated moving average (ARIMA) model and nonlinear auto-regressive neural network (NARNN) is proposed to predict the expected incidence cases from December 2012 to May 2013, using the retrospective observations obtained from China Information System for Disease Control and Prevention from January 2008 to November 2012. Results The best-fitted hybrid model was combined with seasonal ARIMA and NARNN with 15 hidden units and 5 delays. The hybrid model makes the good forecasting performance and estimates the expected incidence cases from December 2012 to May 2013, which are respectively −965.03, −1879.58, 4138.26, 1858.17, 4061.86 and 6163.16 with an obviously increasing trend. Conclusion The model proposed in this paper can predict the incidence trend of HFMD effectively, which could be helpful to policy makers. The usefulness of expected cases of HFMD perform not only in detecting outbreaks or providing probability statements, but also in providing decision makers with a probable trend of the variability of future observations that contains both historical and recent information. PMID:24893000

  10. Integration and Validation in Hybrid-Online Teacher Preparation: A Case Study of Persistence in a Native American Special Education Licensure Program

    ERIC Educational Resources Information Center

    Patterson, Donna Rose

    2013-01-01

    This study explored persistence through the experience of professional studies students in a special education licensure program. The context of the study was a graduate level teacher preparation program delivered in a hybrid format of face-to-face and online learning environments. The goal of the program was to prepare teachers from a Native…

  11. Quantum Monte Carlo simulations of tunneling in quantum adiabatic optimization

    NASA Astrophysics Data System (ADS)

    Brady, Lucas T.; van Dam, Wim

    2016-03-01

    We explore to what extent path-integral quantum Monte Carlo methods can efficiently simulate quantum adiabatic optimization algorithms during a quantum tunneling process. Specifically we look at symmetric cost functions defined over n bits with a single potential barrier that a successful quantum adiabatic optimization algorithm will have to tunnel through. The height and width of this barrier depend on n , and by tuning these dependencies, we can make the optimization algorithm succeed or fail in polynomial time. In this article we compare the strength of quantum adiabatic tunneling with that of path-integral quantum Monte Carlo methods. We find numerical evidence that quantum Monte Carlo algorithms will succeed in the same regimes where quantum adiabatic optimization succeeds.

  12. Hybrid mesons

    NASA Astrophysics Data System (ADS)

    Meyer, C. A.; Swanson, E. S.

    2015-05-01

    A review of the theoretical and experimental status of hybrid hadrons is presented. The states π1(1400) , π1(1600) , and π1(2015) are thoroughly reviewed, along with experimental results from GAMS, VES, Obelix, COMPASS, KEK, CLEO, Crystal Barrel, CLAS, and BNL. Theoretical lattice results on the gluelump spectrum, adiabatic potentials, heavy and light hybrids, and transition matrix elements are discussed. These are compared with bag, string, flux tube, and constituent gluon models. Strong and electromagnetic decay models are described and compared to lattice gauge theory results. We conclude that while good evidence for the existence of a light isovector exotic meson exists, its confirmation as a hybrid meson awaits discovery of its iso-partners. We also conclude that lattice gauge theory rules out a number of hybrid models and provides a reference to judge the success of others.

  13. Stellarator hybrids

    SciTech Connect

    Furth, H.P.; Ludescher, C.

    1984-08-01

    The present paper briefly reviews the subject of tokamak-stellarator and pinch-stellarator hybrids, and points to two interesting new possibilities: compact-torus-stellarators and mirror-stellarators.

  14. Quantum Monte Carlo simulation with a black hole

    NASA Astrophysics Data System (ADS)

    Benić, Sanjin; Yamamoto, Arata

    2016-05-01

    We perform quantum Monte Carlo simulations in the background of a classical black hole. The lattice discretized path integral is numerically calculated in the Schwarzschild metric and in its approximated metric. We study spontaneous symmetry breaking of a real scalar field theory. We observe inhomogeneous symmetry breaking induced by an inhomogeneous gravitational field.

  15. Monte-carlo calculations for some problems of quantum mechanics

    SciTech Connect

    Novoselov, A. A. Pavlovsky, O. V.; Ulybyshev, M. V.

    2012-09-15

    The Monte-Carlo technique for the calculations of functional integral in two one-dimensional quantum-mechanical problems had been applied. The energies of the bound states in some potential wells were obtained using this method. Also some peculiarities in the calculation of the kinetic energy in the ground state had been studied.

  16. Integrated approach for low-temperature synthesis of high-quality silicon nitride films in PECVD using RF–UHF hybrid plasmas

    NASA Astrophysics Data System (ADS)

    Sahu, B. B.; Shin, Kyung S.; Han, Jeon G.

    2016-02-01

    This study investigates low-temperature plasma nitriding of hydrogenated silicon (SiN x :H) film in radio frequency (RF) and RF–ultra-high frequency (UHF) hybrid plasmas. To study the optimized conditions for the deposition of SiN x :H film, this work adopts a systematic plasma diagnostic approach in the nitrogen–silane and nitrogen–silane–ammonia plasmas. This work also evaluates the capability of plasma and radical formation by utilizing different plasma sources in the PECVD process. For the plasma diagnostics, we have purposefully used the combination of optical emission spectroscopy (OES), intensified CCD (ICCD) camera, vacuum ultraviolet absorption spectroscopy (VUVAS), and RF compensated Langmuir probe (LP). Data reveal that there is significant enhancement in the atomic nitrogen radicals, plasma densities, and film properties using the hybrid plasmas. Measurements show that addition of a small amount of NH3 can significantly reduce the electron temperature, plasma, and radical density. Also, optical and chemical properties of the deposited films are investigated on the basis of plasma diagnostics. Good quality SiN x :H films, with atomic nitrogen to hydrogen ratio of 4:1, are fabricated. The plasma chemistry of the hybrid plasmas is also discussed for its utility for plasma applications.

  17. Wormhole Hamiltonian Monte Carlo

    PubMed Central

    Lan, Shiwei; Streets, Jeffrey; Shahbaba, Babak

    2015-01-01

    In machine learning and statistics, probabilistic inference involving multimodal distributions is quite difficult. This is especially true in high dimensional problems, where most existing algorithms cannot easily move from one mode to another. To address this issue, we propose a novel Bayesian inference approach based on Markov Chain Monte Carlo. Our method can effectively sample from multimodal distributions, especially when the dimension is high and the modes are isolated. To this end, it exploits and modifies the Riemannian geometric properties of the target distribution to create wormholes connecting modes in order to facilitate moving between them. Further, our proposed method uses the regeneration technique in order to adapt the algorithm by identifying new modes and updating the network of wormholes without affecting the stationary distribution. To find new modes, as opposed to redis-covering those previously identified, we employ a novel mode searching algorithm that explores a residual energy function obtained by subtracting an approximate Gaussian mixture density (based on previously discovered modes) from the target density function. PMID:25861551

  18. Reactive canonical Monte Carlo

    NASA Astrophysics Data System (ADS)

    Johnson, J. Karl; Panagiotopoulos, Athanassios Z.; Gubbins, Keith E.

    A new simulation technique is developed for calculating the properties of chemically reactive and associating (hydrogen bonding, charge transfer) systems. We call this new method reactive canonical Monte Carlo (RCMC). In contrast to previous methods for treating chemical reactions, this algorithm is applicable to reactions involving a change in mole number. Stoichiometrically balanced reactions are attempted in the forward and reverse directions to achieve chemical equilibrium. The transition probabilities do not depend on the chemical potentials or chemical potential differences of any of the components. We also extend RCMC to work in concert with the isothermal-isobaric ensemble for simulating chemical reactions at constant pressure, and with the Gibbs ensemble for simultaneous calculation of phase and chemical equilibria. Association is treated as a chemical reaction in the RCMC formalism. Results are presented for dimerization of simple model associating fluids. In contrast to previous methods, the reactive Gibbs ensemble can be used to calculate phase equilibrium for associating fluids with very strong bonding sites. RCMC simulations are performed for nitric oxide dimerization and results are compared with available experimental data in the liquid phase. Agreement with experiment is excellent. Results for a vapour phase simulation are also in remarkable agreement with estimates based on second virial coefficient data.

  19. Extension of the fully coupled Monte Carlo/S sub N response matrix method to problems including upscatter and fission

    SciTech Connect

    Baker, R.S.; Filippone, W.F. . Dept. of Nuclear and Energy Engineering); Alcouffe, R.E. )

    1991-01-01

    The neutron transport equation is solved by a hybrid method that iteratively couples regions where deterministic (S{sub N}) and stochastic (Monte Carlo) methods are applied. Unlike previous hybrid methods, the Monte Carlo and S{sub N} regions are fully coupled in the sense that no assumption is made about geometrical separation of decoupling. The fully coupled Monte Carlo/S{sub N} technique consists of defining spatial and/or energy regions of a problem in which either a Monte Carlo calculation or an S{sub N} calculation is to be performed. The Monte Carlo and S{sub N} regions are then connected through the common angular boundary fluxes, which are determined iteratively using the response matrix technique, and group sources. The hybrid method provides a new method of solving problems involving both optically thick and optically thin regions that neither Monte Carlo nor S{sub N} is well suited for by itself. The fully coupled Monte Carlo/S{sub N} method has been implemented in the S{sub N} code TWODANT by adding special-purpose Monte Carlo subroutines to calculate the response matrices and group sources, and linkage subroutines to carry out the interface flux iterations. The common angular boundary fluxes are included in the S{sub N} code as interior boundary sources, leaving the logic for the solution of the transport flux unchanged, while, with minor modifications, the diffusion synthetic accelerator remains effective in accelerating the S{sub N} calculations. The Monte Carlo routines have been successfully vectorized, with approximately a factor of five increases in speed over the nonvectorized version. The hybrid method is capable of solving forward, inhomogeneous source problems in X-Y and R-Z geometries. This capability now includes mulitigroup problems involving upscatter and fission in non-highly multiplying systems. 8 refs., 8 figs., 1 tab.

  20. Isotropic Monte Carlo Grain Growth

    Energy Science and Technology Software Center (ESTSC)

    2013-04-25

    IMCGG performs Monte Carlo simulations of normal grain growth in metals on a hexagonal grid in two dimensions with periodic boundary conditions. This may be performed with either an isotropic or a misorientation - and incliantion-dependent grain boundary energy.

  1. Monte Carlo Capabilities of the SCALE Code System

    NASA Astrophysics Data System (ADS)

    Rearden, B. T.; Petrie, L. M.; Peplow, D. E.; Bekar, K. B.; Wiarda, D.; Celik, C.; Perfetti, C. M.; Ibrahim, A. M.; Hart, S. W. D.; Dunn, M. E.

    2014-06-01

    SCALE is a widely used suite of tools for nuclear systems modeling and simulation that provides comprehensive, verified and validated, user-friendly capabilities for criticality safety, reactor physics, radiation shielding, and sensitivity and uncertainty analysis. For more than 30 years, regulators, licensees, and research institutions around the world have used SCALE for nuclear safety analysis and design. SCALE provides a "plug-and-play" framework that includes three deterministic and three Monte Carlo radiation transport solvers that can be selected based on the desired solution, including hybrid deterministic/Monte Carlo simulations. SCALE includes the latest nuclear data libraries for continuous-energy and multigroup radiation transport as well as activation, depletion, and decay calculations. SCALE's graphical user interfaces assist with accurate system modeling, visualization, and convenient access to desired results. SCALE 6.2, to be released in 2014, will provide several new capabilities and significant improvements in many existing features, especially with expanded continuous-energy Monte Carlo capabilities for criticality safety, shielding, depletion, and sensitivity and uncertainty analysis. An overview of the Monte Carlo capabilities of SCALE is provided here, with emphasis on new features for SCALE 6.2.

  2. Integrated fast assembly of free-standing lithium titanate/carbon nanotube/cellulose nanofiber hybrid network film as flexible paper-electrode for lithium-ion batteries.

    PubMed

    Cao, Shaomei; Feng, Xin; Song, Yuanyuan; Xue, Xin; Liu, Hongjiang; Miao, Miao; Fang, Jianhui; Shi, Liyi

    2015-05-27

    A free-standing lithium titanate (Li4Ti5O12)/carbon nanotube/cellulose nanofiber hybrid network film is successfully assembled by using a pressure-controlled aqueous extrusion process, which is highly efficient and easily to scale up from the perspective of disposable and recyclable device production. This hybrid network film used as a lithium-ion battery (LIB) electrode has a dual-layer structure consisting of Li4Ti5O12/carbon nanotube/cellulose nanofiber composites (hereinafter referred to as LTO/CNT/CNF), and carbon nanotube/cellulose nanofiber composites (hereinafter referred to as CNT/CNF). In the heterogeneous fibrous network of the hybrid film, CNF serves simultaneously as building skeleton and a biosourced binder, which substitutes traditional toxic solvents and synthetic polymer binders. Of importance here is that the CNT/CNF layer is used as a lightweight current collector to replace traditional heavy metal foils, which therefore reduces the total mass of the electrode while keeping the same areal loading of active materials. The free-standing network film with high flexibility is easy to handle, and has extremely good conductivity, up to 15.0 S cm(-1). The flexible paper-electrode for LIBs shows very good high rate cycling performance, and the specific charge/discharge capacity values are up to 142 mAh g(-1) even at a current rate of 10 C. On the basis of the mild condition and fast assembly process, a CNF template fulfills multiple functions in the fabrication of paper-electrode for LIBs, which would offer an ever increasing potential for high energy density, low cost, and environmentally friendly flexible electronics. PMID:25938940

  3. Hybrid nanoscale inorganic cages

    NASA Astrophysics Data System (ADS)

    MacDonald, Janet E.; Bar Sadan, Maya; Houben, Lothar; Popov, Inna; Banin, Uri

    2010-10-01

    Cage structures exhibit inherent high symmetry and beauty, and both naturally occurring and synthetic molecular-scale cages have been discovered. Their characteristic high surface area and voids have led to their use as catalysts and catalyst supports, filtration media and gas storage materials. Nanometre-scale cage structures have also been synthesized, notably noble-metal cube-shaped cages prepared by galvanic displacement with promising applications in drug delivery and catalysis. Further functionality for nanostructures in general is provided by the concept of hybrid nanoparticles combining two disparate materials on the same system to achieve synergistic properties stemming from unusual material combinations. We report the integration of the two powerful concepts of cages and hybrid nanoparticles. A previously unknown edge growth mechanism has led to a new type of cage-structured hybrid metal-semiconductor nanoparticle; a ruthenium cage was grown selectively on the edges of a faceted copper(I) sulphide nanocrystal, contrary to the more commonly observed facet and island growth modes of other hybrids. The cage motif was extended by exploiting the open frame to achieve empty cages and cages containing other semiconductors. Such previously unknown nano-inorganic cage structures with variable cores and metal frames manifest new chemical, optical and electronic properties and demonstrate possibilities for uses in electrocatalysis.

  4. Hybrid wide-band, low-phase-noise scheme for Raman lasers in atom interferometry by integrating an acousto-optic modulator and a feedback loop.

    PubMed

    Wang, Kai; Yao, Zhanwei; Li, Runbing; Lu, Sibin; Chen, Xi; Wang, Jin; Zhan, Mingsheng

    2016-02-10

    We report a hybrid scheme for phase-coherent Raman lasers with low phase noise in a wide frequency range. In this scheme, a pair of Raman lasers with a frequency difference of 3.04 GHz is generated by the ±1-order diffracted lights of an acousto-optic modulator (1.52 GHz), where a feedback loop is simultaneously applied for suppressing the phase noise. The beat width of the Raman lasers is narrower than 3 Hz. In the low-frequency range, the phase noise of the Raman lasers is suppressed by 35 dB with the feedback. The phase noise is less than -109  dBc/Hz in the high-frequency range. The sensitivity of an atom gyroscope employing the hybrid Raman lasers can be implicitly improved 10 times. Due to the better high-frequency response, the sensitivity is not limited by the durations of Raman pulses. This work is important for improving the performance of atom-interferometer-based measurements. PMID:26906364

  5. SPQR: a Monte Carlo reactor kinetics code. [LMFBR

    SciTech Connect

    Cramer, S.N.; Dodds, H.L.

    1980-02-01

    The SPQR Monte Carlo code has been developed to analyze fast reactor core accident problems where conventional methods are considered inadequate. The code is based on the adiabatic approximation of the quasi-static method. This initial version contains no automatic material motion or feedback. An existing Monte Carlo code is used to calculate the shape functions and the integral quantities needed in the kinetics module. Several sample problems have been devised and analyzed. Due to the large statistical uncertainty associated with the calculation of reactivity in accident simulations, the results, especially at later times, differ greatly from deterministic methods. It was also found that in large uncoupled systems, the Monte Carlo method has difficulty in handling asymmetric perturbations.

  6. Vectorizing and macrotasking Monte Carlo neutral particle algorithms

    SciTech Connect

    Heifetz, D.B.

    1987-04-01

    Monte Carlo algorithms for computing neutral particle transport in plasmas have been vectorized and macrotasked. The techniques used are directly applicable to Monte Carlo calculations of neutron and photon transport, and Monte Carlo integration schemes in general. A highly vectorized code was achieved by calculating test flight trajectories in loops over arrays of flight data, isolating the conditional branches to as few a number of loops as possible. A number of solutions are discussed to the problem of gaps appearing in the arrays due to completed flights, which impede vectorization. A simple and effective implementation of macrotasking is achieved by dividing the calculation of the test flight profile among several processors. A tree of random numbers is used to ensure reproducible results. The additional memory required for each task may preclude using a larger number of tasks. In future machines, the limit of macrotasking may be possible, with each test flight, and split test flight, being a separate task.

  7. Fabrication of high performance flexible micro-supercapacitor arrays with hybrid electrodes of MWNT/V2O5 nanowires integrated with a SnO2 nanowire UV sensor

    NASA Astrophysics Data System (ADS)

    Kim, Daeil; Yun, Junyeong; Lee, Geumbee; Ha, Jeong Sook

    2014-09-01

    We report on the on-chip fabrication of high performance flexible micro-supercapacitor (MSC) arrays with hybrid electrodes of multi-walled carbon nanotube (MWNT)/V2O5 nanowire (NW) composites and a solid electrolyte, which could power the SnO2 NW UV sensor integrated on the same flexible substrate. The patterned MSC using hybrid electrodes of MWNT/V2O5 NW composites with 10 vol% of V2O5 NWs exhibited excellent electrochemical performance with a high volume capacitance of 80 F cm-3 at a scan rate of 10 mV s-1 in a PVA-LiCl electrolyte and good cycle performance to maintain 82% of the capacitance after 10 000 cycles at a current density of 11.6 A cm-3. The patterned MSC also showed an excellent energy density of 6.8 mW h cm-3, comparable to that of a Li-thin film battery (1-10 mW h cm-3), and a power density of 80.8 W cm-3 comparable to that of state-of-the-art MSCs. In addition, the flexible MSC array on a PET substrate showed mechanical stability over bending with a bending radius down to 1.5 mm under both compressive and tensile stress. Even after 1000 bending cycles at a bending radius of 7 mm, 94% of the initial capacitance was maintained. Furthermore, we have shown the operation of a SnO2 NW UV sensor using such a fabricated MSC array integrated into the same circuit on the PET substrate.We report on the on-chip fabrication of high performance flexible micro-supercapacitor (MSC) arrays with hybrid electrodes of multi-walled carbon nanotube (MWNT)/V2O5 nanowire (NW) composites and a solid electrolyte, which could power the SnO2 NW UV sensor integrated on the same flexible substrate. The patterned MSC using hybrid electrodes of MWNT/V2O5 NW composites with 10 vol% of V2O5 NWs exhibited excellent electrochemical performance with a high volume capacitance of 80 F cm-3 at a scan rate of 10 mV s-1 in a PVA-LiCl electrolyte and good cycle performance to maintain 82% of the capacitance after 10 000 cycles at a current density of 11.6 A cm-3. The patterned MSC also showed an excellent energy density of 6.8 mW h cm-3, comparable to that of a Li-thin film battery (1-10 mW h cm-3), and a power density of 80.8 W cm-3 comparable to that of state-of-the-art MSCs. In addition, the flexible MSC array on a PET substrate showed mechanical stability over bending with a bending radius down to 1.5 mm under both compressive and tensile stress. Even after 1000 bending cycles at a bending radius of 7 mm, 94% of the initial capacitance was maintained. Furthermore, we have shown the operation of a SnO2 NW UV sensor using such a fabricated MSC array integrated into the same circuit on the PET substrate. Electronic supplementary information (ESI) available. See DOI: 10.1039/c4nr04138k

  8. Cooling/grounding mount for hybrid circuits

    NASA Technical Reports Server (NTRS)

    Bagstad, B.; Estrada, R.; Mandel, H.

    1981-01-01

    Extremely short input and output connections, adequate grounding, and efficient heat removal for hybrid integrated circuits are possible with mounting. Rectangular clamp holds hybrid on printed-circuit board, in contact with heat-conductive ground plate. Clamp is attached to ground plane by bolts.

  9. Hybrid electronic control unit

    SciTech Connect

    Carp, R.W.; Kudlaty, P.R.; Weissler, H.E.

    1981-12-22

    A hybrid electronic control unit for regulating the air/fuel ratio of an internal combustion engine is disclosed. The electronic control unit is divided into two functionally distinct parts including an analog function generator and a digital function generator. The analog function generator receives analog signals to process efficiently by analog scaling, amplification, multiplication, and division while the digital function generator receives digital and logic inputs to process efficiently by addition, subtraction, and comparison. The analog function generator interfaces with the digital function generator by an analog signal from a d/a converter and other unconverted digital output signals from the digital function generator. Preferably, the analog function generator provides an open loop air/fuel ratio calibration based upon a speed density calculation including special condition corrections to the base calibration. Primarily, the digital function generator is a microprocessor implemented closed loop integral controller providing a closed loop correction signal to the open loop scheduler. The closed loop correction signal is provided from the digital function generator by a pair of cascaded digital integrators having different authority levels and integration rates. The cascade is formed by combining an asymmetric primary integrator waveform which has one rpm dependent ramp rate with a symmetric secondary integrator waveform which has a time dependent ramp rate. The primary integrator has a smaller authority and a faster ramp rate than the secondary integrator.

  10. Fabrication of high performance flexible micro-supercapacitor arrays with hybrid electrodes of MWNT/V2O5 nanowires integrated with a SnO2 nanowire UV sensor.

    PubMed

    Kim, Daeil; Yun, Junyeong; Lee, Geumbee; Ha, Jeong Sook

    2014-10-21

    We report on the on-chip fabrication of high performance flexible micro-supercapacitor (MSC) arrays with hybrid electrodes of multi-walled carbon nanotube (MWNT)/V2O5 nanowire (NW) composites and a solid electrolyte, which could power the SnO2 NW UV sensor integrated on the same flexible substrate. The patterned MSC using hybrid electrodes of MWNT/V2O5 NW composites with 10 vol% of V2O5 NWs exhibited excellent electrochemical performance with a high volume capacitance of 80 F cm(-3) at a scan rate of 10 mV s(-1) in a PVA-LiCl electrolyte and good cycle performance to maintain 82% of the capacitance after 10,000 cycles at a current density of 11.6 A cm(-3). The patterned MSC also showed an excellent energy density of 6.8 mW h cm(-3), comparable to that of a Li-thin film battery (1-10 mW h cm(-3)), and a power density of 80.8 W cm(-3) comparable to that of state-of-the-art MSCs. In addition, the flexible MSC array on a PET substrate showed mechanical stability over bending with a bending radius down to 1.5 mm under both compressive and tensile stress. Even after 1000 bending cycles at a bending radius of 7 mm, 94% of the initial capacitance was maintained. Furthermore, we have shown the operation of a SnO2 NW UV sensor using such a fabricated MSC array integrated into the same circuit on the PET substrate. PMID:25184811

  11. An Integrated In Silico Method to Discover Novel Rock1 Inhibitors: Multi- Complex-Based Pharmacophore, Molecular Dynamics Simulation and Hybrid Protocol Virtual Screening.

    PubMed

    Chen, Haining; Li, Sijia; Hu, Yajiao; Chen, Guo; Jiang, Qinglin; Tong, Rongsheng; Zang, Zhihe; Cai, Lulu

    2016-01-01

    Rho-associated, coiled-coil containing protein kinase 1 (ROCK1) is an important regulator of focal adhesion, actomyosin contraction and cell motility. In this manuscript, a combination of the multi-complex-based pharmacophore (MCBP), molecular dynamics simulation and a hybrid protocol of a virtual screening method, comprised of multipharmacophore- based virtual screening (PBVS) and ensemble docking-based virtual screening (DBVS) methods were used for retrieving novel ROCK1 inhibitors from the natural products database embedded in the ZINC database. Ten hit compounds were selected from the hit compounds, and five compounds were tested experimentally. Thus, these results may provide valuable information for further discovery of more novel ROCK1 inhibitors. PMID:26632439

  12. QED multiphoton corrections to Bhabha scattering at low angels. Monte Carlo solution

    NASA Astrophysics Data System (ADS)

    Jadach, S.; Richter-Ws, E.; Ward, B. F. L.; Ws, Z.

    1991-10-01

    We calculate the QED-corrected integrated cross-section for small-angle Bhabha scattering with kinematical cuts very close to the real experimental cuts at the LEP/SLC experiments - no distinction between electrons and photons is made. We effectively compare up to four independent Monte Carlo calculations and one semi-analytical calculation. The aim of the exercise is to establish precision of the O (α) Monte Carlo calculation with the exclusive exponentiation of the Yennie-Frautschi-Suura type. It provides the integrated cross-section for the low-angle Bhabha scattering process (ϑ<10°), necessary for luminosity measurement, with an overall precision of 0.25%. The corresponding computer program BHLUMI 2.00 is in the form of a stand-alone Monte Carlo event generator. The complete and explicit definition of the multiphoton matrix element is given. Examples of numerical results from Monte Carlo phase space integration are demonstrated and discussed.

  13. Continuous-time quantum Monte Carlo using worm sampling

    NASA Astrophysics Data System (ADS)

    Gunacker, P.; Wallerberger, M.; Gull, E.; Hausoel, A.; Sangiovanni, G.; Held, K.

    2015-10-01

    We present a worm sampling method for calculating one- and two-particle Green's functions using continuous-time quantum Monte Carlo simulations in the hybridization expansion (CT-HYB). Instead of measuring Green's functions by removing hybridization lines from partition function configurations, as in conventional CT-HYB, the worm algorithm directly samples the Green's function. We show that worm sampling is necessary to obtain general two-particle Green's functions which are not of density-density type and that it improves the sampling efficiency when approaching the atomic limit. Such two-particle Green's functions are needed to compute off-diagonal elements of susceptibilities and occur in diagrammatic extensions of the dynamical mean-field theory and in efficient estimators for the single-particle self-energy.

  14. Proton Upset Monte Carlo Simulation

    NASA Technical Reports Server (NTRS)

    O'Neill, Patrick M.; Kouba, Coy K.; Foster, Charles C.

    2009-01-01

    The Proton Upset Monte Carlo Simulation (PROPSET) program calculates the frequency of on-orbit upsets in computer chips (for given orbits such as Low Earth Orbit, Lunar Orbit, and the like) from proton bombardment based on the results of heavy ion testing alone. The software simulates the bombardment of modern microelectronic components (computer chips) with high-energy (.200 MeV) protons. The nuclear interaction of the proton with the silicon of the chip is modeled and nuclear fragments from this interaction are tracked using Monte Carlo techniques to produce statistically accurate predictions.

  15. Semiconductor/High-Tc-Superconductor Hybrid ICs

    NASA Technical Reports Server (NTRS)

    Burns, Michael J.

    1995-01-01

    Hybrid integrated circuits (ICs) containing both Si-based semiconducting and YBa(2)Cu(3)O(7-x) superconducting circuit elements on sapphire substrates developed. Help to prevent diffusion of Cu from superconductors into semiconductors. These hybrid ICs combine superconducting and semiconducting features unavailable in superconducting or semiconducting circuitry alone. For example, complementary metal oxide/semiconductor (CMOS) readout and memory devices integrated with fast-switching Josephson-junction super-conducting logic devices and zero-resistance interconnections.

  16. Neutrino oscillation parameter sampling with MonteCUBES

    NASA Astrophysics Data System (ADS)

    Blennow, Mattias; Fernandez-Martinez, Enrique

    2010-01-01

    We present MonteCUBES ("Monte Carlo Utility Based Experiment Simulator"), a software package designed to sample the neutrino oscillation parameter space through Markov Chain Monte Carlo algorithms. MonteCUBES makes use of the GLoBES software so that the existing experiment definitions for GLoBES, describing long baseline and reactor experiments, can be used with MonteCUBES. MonteCUBES consists of two main parts: The first is a C library, written as a plug-in for GLoBES, implementing the Markov Chain Monte Carlo algorithm to sample the parameter space. The second part is a user-friendly graphical Matlab interface to easily read, analyze, plot and export the results of the parameter space sampling. Program summaryProgram title: MonteCUBES (Monte Carlo Utility Based Experiment Simulator) Catalogue identifier: AEFJ_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEFJ_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public Licence No. of lines in distributed program, including test data, etc.: 69 634 No. of bytes in distributed program, including test data, etc.: 3 980 776 Distribution format: tar.gz Programming language: C Computer: MonteCUBES builds and installs on 32 bit and 64 bit Linux systems where GLoBES is installed Operating system: 32 bit and 64 bit Linux RAM: Typically a few MBs Classification: 11.1 External routines: GLoBES [1,2] and routines/libraries used by GLoBES Subprograms used:Cat Id ADZI_v1_0, Title GLoBES, Reference CPC 177 (2007) 439 Nature of problem: Since neutrino masses do not appear in the standard model of particle physics, many models of neutrino masses also induce other types of new physics, which could affect the outcome of neutrino oscillation experiments. In general, these new physics imply high-dimensional parameter spaces that are difficult to explore using classical methods such as multi-dimensional projections and minimizations, such as those used in GLoBES [1,2]. Solution method: MonteCUBES is written as a plug-in to the GLoBES software [1,2] and provides the necessary methods to perform Markov Chain Monte Carlo sampling of the parameter space. This allows an efficient sampling of the parameter space and has a complexity which does not grow exponentially with the parameter space dimension. The integration of the MonteCUBES package with the GLoBES software makes sure that the experimental definitions already in use by the community can also be used with MonteCUBES, while also lowering the learning threshold for users who already know GLoBES. Additional comments: A Matlab GUI for interpretation of results is included in the distribution. Running time: The typical running time varies depending on the dimensionality of the parameter space, the complexity of the experiment, and how well the parameter space should be sampled. The running time for our simulations [3] with 15 free parameters at a Neutrino Factory with O(10) samples varied from a few hours to tens of hours. References:P. Huber, M. Lindner, W. Winter, Comput. Phys. Comm. 167 (2005) 195, hep-ph/0407333. P. Huber, J. Kopp, M. Lindner, M. Rolinec, W. Winter, Comput. Phys. Comm. 177 (2007) 432, hep-ph/0701187. S. Antusch, M. Blennow, E. Fernandez-Martinez, J. Lopez-Pavon, arXiv:0903.3986 [hep-ph].

  17. Integration of Monte Carlo simulations with PFGE experimental data yields constant RBE of 2.3 for DNA double-strand break induction by nitrogen ions between 125 and 225 keV/μm LET.

    PubMed

    Alloni, D; Campa, A; Friedland, W; Mariotti, L; Ottolenghi, A

    2013-06-01

    The number of small radiation-induced DNA fragments can be heavily underestimated when determined from measurements of DNA mass fractions by gel electrophoresis, leading to a consequent underestimation of the initial DNA damage induction. In this study we reanalyzed the experimental results for DNA fragmentation and DNA double-strand break (DSB) yields in human fibroblasts irradiated with γ rays and nitrogen ion beams with linear energy transfer (LET) equal to 80, 125, 175 and 225 keV/μm, originally measured by Höglund et al. (Radiat Res 155, 818-825, 2001 and Int J Radiat Biol 76, 539-547, 2000). In that study the authors converted the measured distributions of fragment masses into DNA fragment distributions using mid-range values of the measured fragment length intervals, in particular they assumed fragments with lengths in the interval of 0-48 kbp had the mid-range value of 24 kbp. However, our recent detailed simulations with the Monte Carlo code PARTRAC, while reasonably in agreement with the mass distributions, indicate significantly increased yields of very short fragments by high-LET radiation, so that the actual average fragment lengths, in the interval 0-48 kbp, 2.4 kbp for 225 keV/μm nitrogen ions were much shorter than the assumed mid-range value of 24 kbp. When the measured distributions of fragment masses are converted into fragment distributions using the average fragment lengths calculated by PARTRAC, significantly higher yields of DSB related to short fragments were obtained and resulted in a constant relative biological effectiveness (RBE) for DSB induction yield of 2.3 for nitrogen ions at 125-225 keV/μm LET. The previously reported downward trend of the RBE values over this LET range for DSB induction appears to be an artifact of an inadequate average fragment length in the smallest interval. PMID:23647004

  18. MontePython: Implementing Quantum Monte Carlo using Python

    NASA Astrophysics Data System (ADS)

    Nilsen, Jon Kristian

    2007-11-01

    We present a cross-language C++/Python program for simulations of quantum mechanical systems with the use of Quantum Monte Carlo (QMC) methods. We describe a system for which to apply QMC, the algorithms of variational Monte Carlo and diffusion Monte Carlo and we describe how to implement theses methods in pure C++ and C++/Python. Furthermore we check the efficiency of the implementations in serial and parallel cases to show that the overhead using Python can be negligible. Program summaryProgram title: MontePython Catalogue identifier: ADZP_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADZP_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 49 519 No. of bytes in distributed program, including test data, etc.: 114 484 Distribution format: tar.gz Programming language: C++, Python Computer: PC, IBM RS6000/320, HP, ALPHA Operating system: LINUX Has the code been vectorised or parallelized?: Yes, parallelized with MPI Number of processors used: 1-96 RAM: Depends on physical system to be simulated Classification: 7.6; 16.1 Nature of problem: Investigating ab initio quantum mechanical systems, specifically Bose-Einstein condensation in dilute gases of 87Rb Solution method: Quantum Monte Carlo Running time: 225 min with 20 particles (with 4800 walkers moved in 1750 time steps) on 1 AMD Opteron TM Processor 2218 processor; Production run for, e.g., 200 particles takes around 24 hours on 32 such processors.

  19. 0.6-1.0 V operation set/reset voltage (3 V) generator for three-dimensional integrated resistive random access memory and NAND flash hybrid solid-state drive

    NASA Astrophysics Data System (ADS)

    Tanaka, Masahiro; Hachiya, Shogo; Ishii, Tomoya; Ning, Sheyang; Tsurumi, Kota; Takeuchi, Ken

    2016-04-01

    A 0.6-1.0 V, 25.9 mm2 boost converter is proposed to generate resistive random access memory (ReRAM) write (set/reset) voltage for three-dimensional (3D) integrated ReRAM and NAND flash hybrid solid-state drive (SSD). The proposed boost converter uses an integrated area-efficient V BUF generation circuit to obtain short ReRAM sector write time, small circuit size, and small energy consumption simultaneously. In specific, the proposed boost converter reduces ReRAM sector write time by 65% compared with a conventional one-stage boost converter (Conventional 1) which uses 1.0 V operating voltage. On the other hand, by using the same ReRAM sector write time, the proposed boost converter reduces 49% circuit area and 46% energy consumption compared with a conventional two-stage boost converter (Conventional 2). In addition, by using the proposed boost converter, the operating voltage, V DD, can be reduced to 0.6 V. The lowest 159 nJ energy consumption can be obtained when V DD is 0.7 V.

  20. Hybrid PolyLingual Object Model: An Efficient and Seamless Integration of Java and Native Components on the Dalvik Virtual Machine

    PubMed Central

    Huang, Yukun; Chen, Rong; Wei, Jingbo; Pei, Xilong; Cao, Jing; Prakash Jayaraman, Prem; Ranjan, Rajiv

    2014-01-01

    JNI in the Android platform is often observed with low efficiency and high coding complexity. Although many researchers have investigated the JNI mechanism, few of them solve the efficiency and the complexity problems of JNI in the Android platform simultaneously. In this paper, a hybrid polylingual object (HPO) model is proposed to allow a CAR object being accessed as a Java object and as vice in the Dalvik virtual machine. It is an acceptable substitute for JNI to reuse the CAR-compliant components in Android applications in a seamless and efficient way. The metadata injection mechanism is designed to support the automatic mapping and reflection between CAR objects and Java objects. A prototype virtual machine, called HPO-Dalvik, is implemented by extending the Dalvik virtual machine to support the HPO model. Lifespan management, garbage collection, and data type transformation of HPO objects are also handled in the HPO-Dalvik virtual machine automatically. The experimental result shows that the HPO model outweighs the standard JNI in lower overhead on native side, better executing performance with no JNI bridging code being demanded. PMID:25110745

  1. An integrated strategy to quantitatively differentiate chemome between Cistanche deserticola and C. tubulosa using high performance liquid chromatography-hybrid triple quadrupole-linear ion trap mass spectrometry.

    PubMed

    Song, Yuelin; Song, Qingqing; Li, Jun; Zhang, Na; Zhao, Yunfang; Liu, Xiao; Jiang, Yong; Tu, Pengfei

    2016-01-15

    It is important to conduct large-scale detection, identification, and quantitation of metabolites in a given sample. Herein, a practical strategy was proposed to quantitatively compare the chemome between Cistanche deserticola (CD) and C. tubulosa (CT), which have been widely believed as the ideal edible and medicinal plants for conquering the deserts. The entire workflow was implemented on high performance liquid chromatography-hybrid triple quadrupole-linear ion trap mass spectrometer and consisted of three primary steps: (1) component detection and identification, various mass spectrometric approaches were applied to globally screen the chemical constituents, and structural elucidation was achieved by comparing with authentic compounds, analyzing MS(2) spectra, and referring to the literature along with accessible databases; (2) comprehensive relative quantitation, scheduled multiple reaction monitoring algorithm was introduced for relative quantitation of all detected ingredients; and (3) chemome comparison, the quantitative dataset was subjected for multivariate statistical analysis to carry out comparative study. A total of 513 metabolites were detected and relatively quantitated, and 379 ones were annotated. Betaine, Krebs cycle intermediates, phenylethanoid glycosides, and iridoids were picked out as the chemical markers being responsible for the discrimination of the chemical profiles between CD and CT. Above all, the quantitative chemome of CD and CT were exhaustively characterized and compared, which could advance their values concerning drug development, economics, and desertification control. The proposed strategy is expected as a reliable choice for widely targeted metabolomics of plants. PMID:26742897

  2. Microfluidic Integration of a Cloth-Based Hybridization Array System (CHAS) for Rapid, Colorimetric Detection of Enterohemorrhagic Escherichia coli (EHEC) Using an Articulated, Centrifugal Platform.

    PubMed

    Geissler, Matthias; Clime, Liviu; Hoa, Xuyen D; Morton, Keith J; Hébert, Harold; Poncelet, Lucas; Mounier, Maxence; Deschênes, Mylène; Gauthier, Martine E; Huszczynski, George; Corneau, Nathalie; Blais, Burton W; Veres, Teodor

    2015-10-20

    We describe the translation of a cloth-based hybridization array system (CHAS), a colorimetric DNA detection method that is used by food inspection laboratories for colony screening of pathogenic agents, onto a microfluidic chip format. We also introduce an articulated centrifugal platform with a novel fluid manipulation concept based on changes in the orientation of the chip with respect to the centrifugal force field to time the passage of multiple components required for the process. The platform features two movable and motorized carriers that can be reoriented on demand between 0 and 360° during stage rotation. Articulation of the chip can be used to trigger on-the-fly fluid dispensing through independently addressable siphon structures or to relocate solutions against the centrifugal force field, making them newly accessible for downstream transfer. With the microfluidic CHAS, we achieved significant reduction in the size of the cloth substrate as well as the volume of reagents and wash solutions. Both the chip design and the operational protocol were optimized to perform the entire process in a reliable, fully automated fashion. A demonstration with PCR-amplified genomic DNA confirms on-chip detection and identification of Escherichia coli O157:H7 from colony isolates in a colorimetric multiplex assay using rfbO157, fliCH7, vt1, and vt2 genes. PMID:26416260

  3. Monte Carlo calculations of nuclei

    SciTech Connect

    Pieper, S.C.

    1997-10-01

    Nuclear many-body calculations have the complication of strong spin- and isospin-dependent potentials. In these lectures the author discusses the variational and Green`s function Monte Carlo techniques that have been developed to address this complication, and presents a few results.

  4. Is Monte Carlo embarrassingly parallel?

    SciTech Connect

    Hoogenboom, J. E.

    2012-07-01

    Monte Carlo is often stated as being embarrassingly parallel. However, running a Monte Carlo calculation, especially a reactor criticality calculation, in parallel using tens of processors shows a serious limitation in speedup and the execution time may even increase beyond a certain number of processors. In this paper the main causes of the loss of efficiency when using many processors are analyzed using a simple Monte Carlo program for criticality. The basic mechanism for parallel execution is MPI. One of the bottlenecks turn out to be the rendez-vous points in the parallel calculation used for synchronization and exchange of data between processors. This happens at least at the end of each cycle for fission source generation in order to collect the full fission source distribution for the next cycle and to estimate the effective multiplication factor, which is not only part of the requested results, but also input to the next cycle for population control. Basic improvements to overcome this limitation are suggested and tested. Also other time losses in the parallel calculation are identified. Moreover, the threading mechanism, which allows the parallel execution of tasks based on shared memory using OpenMP, is analyzed in detail. Recommendations are given to get the maximum efficiency out of a parallel Monte Carlo calculation. (authors)

  5. A Residual Monte Carlo Method for Spatially Discrete, Angularly Continuous Radiation Transport

    SciTech Connect

    Wollaeger, Ryan T.; Densmore, Jeffery D.

    2012-06-19

    Residual Monte Carlo provides exponential convergence of statistical error with respect to the number of particle histories. In the past, residual Monte Carlo has been applied to a variety of angularly discrete radiation-transport problems. Here, we apply residual Monte Carlo to spatially discrete, angularly continuous transport. By maintaining angular continuity, our method avoids the deficiencies of angular discretizations, such as ray effects. For planar geometry and step differencing, we use the corresponding integral transport equation to calculate an angularly independent residual from the scalar flux in each stage of residual Monte Carlo. We then demonstrate that the resulting residual Monte Carlo method does indeed converge exponentially to within machine precision of the exact step differenced solution.

  6. Applications of Monte Carlo Methods in Calculus.

    ERIC Educational Resources Information Center

    Gordon, Sheldon P.; Gordon, Florence S.

    1990-01-01

    Discusses the application of probabilistic ideas, especially Monte Carlo simulation, to calculus. Describes some applications using the Monte Carlo method: Riemann sums; maximizing and minimizing a function; mean value theorems; and testing conjectures. (YP)

  7. Printed hybrid systems

    NASA Astrophysics Data System (ADS)

    Karioja, Pentti; Mäkinen, Jukka-Tapani; Keränen, Kimmo; Aikio, Janne; Alajoki, Teemu; Jaakola, Tuomo; Koponen, Matti; Keränen, Antti; Heikkinen, Mikko; Tuomikoski, Markus; Suhonen, Riikka; Hakalahti, Leena; Kopola, Pälvi; Hast, Jukka; Liedert, Ralf; Hiltunen, Jussi; Masuda, Noriyuki; Kemppainen, Antti; Rönkä, Kari; Korhonen, Raimo

    2012-04-01

    This paper presents research activities carried out at VTT Technical Research Centre of Finland in the field of hybrid integration of optics, electronics and mechanics. Main focus area in our research is the manufacturing of electronic modules and product structures with printed electronics, film-over-molding and polymer sheet lamination technologies and the goal is in the next generation of smart systems utilizing monolithic polymer packages. The combination of manufacturing technologies such as roll-to-roll -printing, injection molding and traditional component assembly is called Printed Hybrid Systems (PHS). Several demonstrator structures have been made, which show the potential of polymer packaging technology. One demonstrator example is a laminated structure with embedded LED chips. Element thickness is only 0.3mm and the flexible stack of foils can be bent in two directions after assembly process and was shaped curved using heat and pressure. The combination of printed flexible circuit boards and injection molding has also been demonstrated with several functional modules. The demonstrators illustrate the potential of origami electronics, which can be cut and folded to 3D shapes. It shows that several manufacturing process steps can be eliminated by Printed Hybrid Systems technology. The main benefits of this combination are small size, ruggedness and conformality. The devices are ideally suited for medical applications as the sensitive electronic components are well protected inside the plastic and the structures can be cleaned easily due to the fact that they have no joints or seams that can accumulate dirt or bacteria.

  8. Mission Analysis, Operations, and Navigation Toolkit Environment (Monte) Version 040

    NASA Technical Reports Server (NTRS)

    Sunseri, Richard F.; Wu, Hsi-Cheng; Evans, Scott E.; Evans, James R.; Drain, Theodore R.; Guevara, Michelle M.

    2012-01-01

    Monte is a software set designed for use in mission design and spacecraft navigation operations. The system can process measurement data, design optimal trajectories and maneuvers, and do orbit determination, all in one application. For the first time, a single software set can be used for mission design and navigation operations. This eliminates problems due to different models and fidelities used in legacy mission design and navigation software. The unique features of Monte 040 include a blowdown thruster model for GRAIL (Gravity Recovery and Interior Laboratory) with associated pressure models, as well as an updated, optimalsearch capability (COSMIC) that facilitated mission design for ARTEMIS. Existing legacy software lacked the capabilities necessary for these two missions. There is also a mean orbital element propagator and an osculating to mean element converter that allows long-term orbital stability analysis for the first time in compiled code. The optimized trajectory search tool COSMIC allows users to place constraints and controls on their searches without any restrictions. Constraints may be user-defined and depend on trajectory information either forward or backwards in time. In addition, a long-term orbit stability analysis tool (morbiter) existed previously as a set of scripts on top of Monte. Monte is becoming the primary tool for navigation operations, a core competency at JPL. The mission design capabilities in Monte are becoming mature enough for use in project proposals as well as post-phase A mission design. Monte has three distinct advantages over existing software. First, it is being developed in a modern paradigm: object- oriented C++ and Python. Second, the software has been developed as a toolkit, which allows users to customize their own applications and allows the development team to implement requirements quickly, efficiently, and with minimal bugs. Finally, the software is managed in accordance with the CMMI (Capability Maturity Model Integration), where it has been ap praised at maturity level 3.

  9. Calculations of pair production by Monte Carlo methods

    SciTech Connect

    Bottcher, C.; Strayer, M.R.

    1991-01-01

    We describe some of the technical design issues associated with the production of particle-antiparticle pairs in very large accelerators. To answer these questions requires extensive calculation of Feynman diagrams, in effect multi-dimensional integrals, which we evaluate by Monte Carlo methods on a variety of supercomputers. We present some portable algorithms for generating random numbers on vector and parallel architecture machines. 12 refs., 14 figs.

  10. Shell-model Monte Carlo calculations in nuclei

    SciTech Connect

    Dean, D.J. |

    1998-11-01

    The author`s research over the past few years has been in the area of the nuclear shell model solved not by diagonalization, but by integration. In what follows, the author describes the shell-model Monte Carlo (SMMC) method, and discusses two recent and interesting results obtained from theory. These include calculations of electron-capture rates in fp-shell nuclei, and pairing correlations in medium-mass nuclei near N = Z.

  11. Monte Carlo Methods and Applications for the Nuclear Shell Model

    SciTech Connect

    Dean, D.J.; White, J.A.

    1998-08-10

    The shell-model Monte Carlo (SMMC) technique transforms the traditional nuclear shell-model problem into a path-integral over auxiliary fields. We describe below the method and its applications to four physics issues: calculations of sd-pf-shell nuclei, a discussion of electron-capture rates in pf-shell nuclei, exploration of pairing correlations in unstable nuclei, and level densities in rare earth systems.

  12. Monte Carlo Simulation for Perusal and Practice.

    ERIC Educational Resources Information Center

    Brooks, Gordon P.; Barcikowski, Robert S.; Robey, Randall R.

    The meaningful investigation of many problems in statistics can be solved through Monte Carlo methods. Monte Carlo studies can help solve problems that are mathematically intractable through the analysis of random samples from populations whose characteristics are known to the researcher. Using Monte Carlo simulation, the values of a statistic are…

  13. Hybrid Models of Tumor Growth

    PubMed Central

    Rejniak, Katarzyna A.; Anderson, Alexander R. A.

    2010-01-01

    Cancer is a complex, multiscale process, in which genetic mutations occurring at a subcellular level manifest themselves as functional changes at the cellular and tissue scale. The multiscale nature of cancer requires mathematical modeling approaches that can handle multiple intra- and extracellular factors acting on different time and space scales. Hybrid models provide a way to integrate both discrete and continuous variables that are used to represent individual cells and concentration or density fields, respectively. Each discrete cell can also be equipped with sub-models that drive cell behavior in response to microenvironmental cues. Moreover, the individual cells can interact with one another to form and act as an integrated tissue. Hybrid models form part of a larger class of individual-based-models that can naturally connect with tumor cell biology and allow for the integration of multiple interacting variables both intrinsically and extrinsically and are therefore perfectly suited to a systems biology approach to tumor growth. PMID:21064037

  14. Novel Quantum Monte Carlo Approaches for Quantum Liquids

    NASA Astrophysics Data System (ADS)

    Rubenstein, Brenda M.

    Quantum Monte Carlo methods are a powerful suite of techniques for solving the quantum many-body problem. By using random numbers to stochastically sample quantum properties, QMC methods are capable of studying low-temperature quantum systems well beyond the reach of conventional deterministic techniques. QMC techniques have likewise been indispensible tools for augmenting our current knowledge of superfluidity and superconductivity. In this thesis, I present two new quantum Monte Carlo techniques, the Monte Carlo Power Method and Bose-Fermi Auxiliary-Field Quantum Monte Carlo, and apply previously developed Path Integral Monte Carlo methods to explore two new phases of quantum hard spheres and hydrogen. I lay the foundation for a subsequent description of my research by first reviewing the physics of quantum liquids in Chapter One and the mathematics behind Quantum Monte Carlo algorithms in Chapter Two. I then discuss the Monte Carlo Power Method, a stochastic way of computing the first several extremal eigenvalues of a matrix too memory-intensive to be stored and therefore diagonalized. As an illustration of the technique, I demonstrate how it can be used to determine the second eigenvalues of the transition matrices of several popular Monte Carlo algorithms. This information may be used to quantify how rapidly a Monte Carlo algorithm is converging to the equilibrium probability distribution it is sampling. I next present the Bose-Fermi Auxiliary-Field Quantum Monte Carlo algorithm. This algorithm generalizes the well-known Auxiliary-Field Quantum Monte Carlo algorithm for fermions to bosons and Bose-Fermi mixtures. Despite some shortcomings, the Bose-Fermi Auxiliary-Field Quantum Monte Carlo algorithm represents the first exact technique capable of studying Bose-Fermi mixtures of any size in any dimension. In Chapter Six, I describe a new Constant Stress Path Integral Monte Carlo algorithm for the study of quantum mechanical systems under high pressures. While the eventual hope is to apply this algorithm to the exploration of yet unidentified high-pressure, low-temperature phases of hydrogen, I employ this algorithm to determine whether or not quantum hard spheres can form a low-temperature bcc solid if exchange is not taken into account. In the final chapter of this thesis, I use Path Integral Monte Carlo once again to explore whether glassy para-hydrogen exhibits superfluidity. Physicists have long searched for ways to coax hydrogen into becoming a superfluid. I present evidence that, while glassy hydrogen does not crystallize at the temperatures at which hydrogen might become a superfluid, it nevertheless does not exhibit superfluidity. This is because the average binding energy per p-H2 molecule poses a severe barrier to exchange regardless of whether the system is crystalline. All in all, this work extends the reach of Quantum Monte Carlo methods to new systems and brings the power of existing methods to bear on new problems. Portions of this work have been published in Rubenstein, PRE (2010) and Rubenstein, PRA (2012) [167;169]. Other papers not discussed here published during my Ph.D. include Rubenstein, BPJ (2008) and Rubenstein, PRL (2012) [166;168]. The work in Chapters 6 and 7 is currently unpublished. [166] Brenda M. Rubenstein, Ivan Coluzza, and Mark A. Miller. Controlling the folding and substrate-binding of proteins using polymer brushes. Physical Review Letters, 108(20):208104, May 2012. [167] Brenda M. Rubenstein, J.E. Gubernatis, and J.D. Doll. Comparative monte carlo efficiency by monte carlo analysis. Physical Review E, 82(3):036701, September 2010. [168] Brenda M. Rubenstein and Laura J. Kaufman. The role of extracellular matrix in glioma invasion: A cellular potts model approach. Biophysical Journal, 95(12):5661-- 5680, December 2008. [169] Brenda M. Rubenstein, Shiwei Zhang, and David R. Reichman. Finite-temperature auxiliary-field quantum monte carlo for bose-fermi mixtures. Physical Review A, 86(5):053606, November 2012.

  15. Hybrid Gear

    NASA Technical Reports Server (NTRS)

    Handschuh, Robert F. (Inventor); Roberts, Gary D. (Inventor)

    2016-01-01

    A hybrid gear consisting of metallic outer rim with gear teeth and metallic hub in combination with a composite lay up between the shaft interface (hub) and gear tooth rim is described. The composite lay-up lightens the gear member while having similar torque carrying capability and it attenuates the impact loading driven noise/vibration that is typical in gear systems. The gear has the same operational capability with respect to shaft speed, torque, and temperature as an all-metallic gear as used in aerospace gear design.

  16. Fast fabrication of integrated surface-relief and particle-diffusing plastic diffuser by use of a hybrid extrusion roller embossing process.

    PubMed

    Huang, Tzu-Chien; Ciou, Jian-Ren; Huang, Po-Hsun; Hsieh, Kuo-Huang; Yang, Sen-Yeu

    2008-01-01

    Most plastic diffusers are either of surface-relief or particle-diffusing types, based on different principles and fabrication methods. This paper reports an innovative extrusion roller embossing process, which enables the fabrication of diffusers with both surface-relief and particle-diffusing functions. An extruder with die is employed to fabricate the thin film of PC/bead composite; the roller micro-embossing process is used to replicate the microstructure onto the surface of PC composite film. A metallic roller mold with microstructures is fabricated using turning process. During the extrusion rolling embossing process, the extruded film of PC with diffusion beads is immediately pressed against the surface of the roller mold. Under the proper processing parameters, the plastic diffusers integrating surface-relief and particle-diffusing functions have been successfully fabricated. The shape, uniformity, and optical properties of fabricated diffuser have been verified. This method shows the great potential for continuous fabrication of high-performance plastic diffusers integrating surface-relief and particle-diffusing functions with high throughput. PMID:18521176

  17. Hybrid Simulator

    Energy Science and Technology Software Center (ESTSC)

    2005-10-15

    HybSim (short for Hybrid Simulator) is a flexible, easy to use screening tool that allows the user to quanti the technical and economic benefits of installing a village hybrid generating system and simulates systems with any combination of —Diesel generator sets —Photovoltaic arrays -Wind Turbines and -Battery energy storage systems Most village systems (or small population sites such as villages, remote military bases, small communities, independent or isolated buildings or centers) depend on diesel generationmore » systems for their source of energy. HybSim allows the user to determine other "sources" of energy that can greatly reduce the dollar to kilo-watt hour ratio. Supported by the DOE, Energy Storage Program, HybSim was initially developed to help analyze the benefits of energy storage systems in Alaskan villages. Soon after its development, other sources of energy were added providing the user with a greater range of analysis opportunities and providing the village with potentially added savings. In addition to village systems, HybSim has generated interest for use from military institutions in energy provisions and USAID for international village analysis.« less

  18. Monte Carlo methods in ICF

    SciTech Connect

    Zimmerman, G.B.

    1997-06-24

    Monte Carlo methods appropriate to simulate the transport of x-rays, neutrons, ion and electrons in Inertial Confinement Fusion targets are described and analyzed. The Implicit Monte Carlo method of x-ray transport handles symmetry within indirect drive ICF hohlraums well, but can be improved 50X in efficiency by angular biasing the x-rays towards the fuel capsule. Accurate simulation of thermonuclear burns nd burn diagnostics involves detailed particle source spectra, charged particle ranges, inflight reaction kinematics, corrections for bulk and thermal Doppler effects and variance reduction to obtain adequate statistics for rare events. It is found that the effects of angular Coulomb scattering must be included in models of charged particle transport through heterogeneous materials.

  19. The D0 Monte Carlo

    SciTech Connect

    Womersley, J. . Dept. of Physics)

    1992-10-01

    The D0 detector at the Fermilab Tevatron began its first data taking run in May 1992. For analysis of the expected 25 pb[sup [minus]1] data sample, roughly half a million simulated events will be needed. The GEANT-based Monte Carlo program used to generate these events is described, together with comparisons to test beam data. Some novel techniques used to speed up execution and simplify geometrical input are described.

  20. Monte Carlo Simulations and Generation of the SPI Response

    NASA Technical Reports Server (NTRS)

    Sturner, S. J.; Shrader, C. R.; Weidenspointner, G.; Teegarden, B. J.; Attie, D.; Cordier, B.; Diehl, R.; Ferguson, C.; Jean, P.; vonKienlin, A.

    2003-01-01

    In this paper we discuss the methods developed for the production of the INTEGRAL/SPI instrument response. The response files were produced using a suite of Monte Carlo simulation software developed at NASA/GSFC based on the GEANT-3 package available from CERN. The production of the INTEGRAL/SPI instrument response also required the development of a detailed computer mass model for SPI. We discuss ow extensive investigations into methods to reduce both the computation time and storage requirements for the SPI response. We also discuss corrections to the simulated response based on our comparison of ground and infiight Calibration data with MGEANT simulations.

  1. Monte Carlo Simulations and Generation of the SPI Response

    NASA Technical Reports Server (NTRS)

    Sturner, S. J.; Shrader, C. R.; Weidenspointner, G.; Teegarden, B. J.; Attie, D.; Diehl, R.; Ferguson, C.; Jean, P.; vonKienlin, A.

    2003-01-01

    In this paper we discuss the methods developed for the production of the INTEGRAL/SPI instrument response. The response files were produced using a suite of Monte Carlo simulation software developed at NASA/GSFC based on the GEANT-3 package available from CERN. The production of the INTEGRAL/SPI instrument response also required the development of a detailed computer mass model for SPI. We discuss our extensive investigations into methods to reduce both the computation time and storage requirements for the SPI response. We also discuss corrections to the simulated response based on our comparison of ground and inflight calibration data with MGEANT simulation.

  2. Approximating Integrals Using Probability

    ERIC Educational Resources Information Center

    Maruszewski, Richard F., Jr.; Caudle, Kyle A.

    2005-01-01

    As part of a discussion on Monte Carlo methods, which outlines how to use probability expectations to approximate the value of a definite integral. The purpose of this paper is to elaborate on this technique and then to show several examples using visual basic as a programming tool. It is an interesting method because it combines two branches of…

  3. a Combination of Replica Exchange Monte Carlo and Energy Landscape Paving Algorithms to Increase the Effectiveness of Conformational Sampling

    NASA Astrophysics Data System (ADS)

    Arkin, Handan

    A combination of replica exchange Monte Carlo sampling techniques and energy landscape paving approach is presented. This hybrid algorithm combines the features of the energy landscape paving (ELP) and replica exchange methods (REM). I have tested its performance in studying the low-energy conformations of the benchmark peptide Met-enkephalin.

  4. Monte Carlo approaches to effective field theories

    SciTech Connect

    Carlson, J. ); Schmidt, K.E. . Dept. of Physics)

    1991-01-01

    In this paper, we explore the application of continuum Monte Carlo methods to effective field theory models. Effective field theories, in this context, are those in which a Fock space decomposition of the state is useful. These problems arise both in nuclear and condensed matter physica. In nuclear physics, much work has been done on effective field theories of mesons and baryons. While the theories are not fundamental, they should be able to describe nuclear properties at low energy and momentum scales. After describing the methods, we solve two simple scalar field theory problems; the polaron and two nucleons interacting through scalar meson exchange. The methods presented here are rather straightforward extensions of methods used to solve quantum mechanics problems. Monte Carlo methods are used to avoid the truncation inherent in a Tamm-Dancoff approach and its associated difficulties. Nevertheless, the methods will be most valuable when the Fock space decomposition of the states is useful. Hence, while they are not intended for ab initio studies of QCD, they may prove valuable in studies of light nuclei, or for systems of interacting electrons and phonons. In these problems a Fock space decomposition can be used to reduce the number of degrees of freedom and to retain the rotational symmetries exactly. The problems we address here are comparatively simple, but offer useful initial tests of the method. We present results for the polaron and two non-relativistic nucleons interacting through scalar meson exchange. In each case, it is possible to integrate out the boson degrees of freedom exactly, and obtain a retarded form of the action that depends only upon the fermion paths. Here we keep the explicit bosons, though, since we would like to retain information about the boson components of the states and it will be necessary to keep these components in order to treat non-scalar of interacting bosonic fields.

  5. Energy, contact, and density profiles of one-dimensional fermions in a harmonic trap via nonuniform-lattice Monte Carlo calculations

    NASA Astrophysics Data System (ADS)

    Berger, C. E.; Anderson, E. R.; Drut, J. E.

    2015-05-01

    We determine the ground-state energy and Tan's contact of attractively interacting few-fermion systems in a one-dimensional harmonic trap, for a range of couplings and particle numbers. Complementing those results, we show the corresponding density profiles. The calculations were performed with a lattice Monte Carlo approach based on a nonuniform discretization of space, defined via Gauss-Hermite quadrature points and weights. This particular coordinate basis is natural for systems in harmonic traps, and can be generalized to traps of other shapes. In all cases, it yields a position-dependent coupling and a corresponding nonuniform Hubbard-Stratonovich transformation. The resulting path integral is performed with hybrid Monte Carlo as a proof of principle for calculations at finite temperature and in higher dimensions. We present results for N =4 ,...,20 particles (although the method can be extended beyond that) to cover the range from few- to many-particle systems. This method is exact up to statistical and systematic uncertainties, which we account for—and thus also represents an ab initio calculation of this system, providing a benchmark for other methods and a prediction for ultracold-atom experiments.

  6. Efficient pseudo-random number generation for monte-carlo simulations using graphic processors

    NASA Astrophysics Data System (ADS)

    Mohanty, Siddhant; Mohanty, A. K.; Carminati, F.

    2012-06-01

    A hybrid approach based on the combination of three Tausworthe generators and one linear congruential generator for pseudo random number generation for GPU programing as suggested in NVIDIA-CUDA library has been used for MONTE-CARLO sampling. On each GPU thread, a random seed is generated on fly in a simple way using the quick and dirty algorithm where mod operation is not performed explicitly due to unsigned integer overflow. Using this hybrid generator, multivariate correlated sampling based on alias technique has been carried out using both CUDA and OpenCL languages.

  7. Monte Carlo simulations of the NJL model near the nonzero temperature phase transition

    NASA Astrophysics Data System (ADS)

    Strouthos, Costas; Christofi, Stavros

    2005-01-01

    We present results from numerical simulations of the Nambu-Jona-Lasinio model with an SU(2)otimesSU(2) chiral symmetry and Nc = 4,8, and 16 quark colors at nonzero temperature. We performed the simulations by utilizing the hybrid Monte Carlo and hybrid Molecular Dynamics algorithms. We show that the model undergoes a second order phase transition. The critical exponents measured are consistent with the classical 3d O(4) universality class and hence in accordance with the dimensional reduction scenario. We also show that the Ginzburg region is suppressed by a factor of 1/Nc in accordance with previous analytical predictions.

  8. Genomic Networks of Hybrid Sterility

    PubMed Central

    Turner, Leslie M.; White, Michael A.; Tautz, Diethard; Payseur, Bret A.

    2014-01-01

    Hybrid dysfunction, a common feature of reproductive barriers between species, is often caused by negative epistasis between loci (“Dobzhansky-Muller incompatibilities”). The nature and complexity of hybrid incompatibilities remain poorly understood because identifying interacting loci that affect complex phenotypes is difficult. With subspecies in the early stages of speciation, an array of genetic tools, and detailed knowledge of reproductive biology, house mice (Mus musculus) provide a model system for dissecting hybrid incompatibilities. Male hybrids between M. musculus subspecies often show reduced fertility. Previous studies identified loci and several X chromosome-autosome interactions that contribute to sterility. To characterize the genetic basis of hybrid sterility in detail, we used a systems genetics approach, integrating mapping of gene expression traits with sterility phenotypes and QTL. We measured genome-wide testis expression in 305 male F2s from a cross between wild-derived inbred strains of M. musculus musculus and M. m. domesticus. We identified several thousand cis- and trans-acting QTL contributing to expression variation (eQTL). Many trans eQTL cluster into eleven ‘hotspots,’ seven of which co-localize with QTL for sterility phenotypes identified in the cross. The number and clustering of trans eQTL—but not cis eQTL—were substantially lower when mapping was restricted to a ‘fertile’ subset of mice, providing evidence that trans eQTL hotspots are related to sterility. Functional annotation of transcripts with eQTL provides insights into the biological processes disrupted by sterility loci and guides prioritization of candidate genes. Using a conditional mapping approach, we identified eQTL dependent on interactions between loci, revealing a complex system of epistasis. Our results illuminate established patterns, including the role of the X chromosome in hybrid sterility. The integrated mapping approach we employed is applicable in a broad range of organisms and we advocate for widespread adoption of a network-centered approach in speciation genetics. PMID:24586194

  9. Characterization of the ePix100 prototype: a front-end ASIC for second-generation LCLS integrating hybrid pixel detectors

    NASA Astrophysics Data System (ADS)

    Caragiulo, P.; Dragone, A.; Markovic, B.; Herbst, R.; Nishimura, K.; Reese, B.; Herrmann, S.; Hart, P.; Blaj, G.; Segal, J.; Tomada, A.; Hasi, J.; Carini, G.; Kenney, C.; Haller, G.

    2014-09-01

    ePix100 is the first variant of a novel class of integrating pixel ASICs architectures optimized for the processing of signals in second generation LINAC Coherent Light Source (LCLS) X-Ray cameras. ePix100 is optimized for ultra-low noise application requiring high spatial resolution. ePix ASICs are based on a common platform composed of a random access analog matrix of pixel with global shutter, fast parallel column readout, and dedicated sigma-delta analog to digital converters per column. The ePix100 variant has 50μmx50μm pixels arranged in a 352x384 matrix, a resolution of 50e- r.m.s. and a signal range of 35fC (100 photons at 8keV). In its final version it will be able to sustain a frame rate of 1kHz. A first prototype has been fabricated and characterized and the measurement results are reported here.

  10. A hybrid framework of first principles molecular orbital calculations and a three-dimensional integral equation theory for molecular liquids: multi-center molecular Ornstein-Zernike self-consistent field approach.

    PubMed

    Kido, Kentaro; Kasahara, Kento; Yokogawa, Daisuke; Sato, Hirofumi

    2015-07-01

    In this study, we reported the development of a new quantum mechanics/molecular mechanics (QM/MM)-type framework to describe chemical processes in solution by combining standard molecular-orbital calculations with a three-dimensional formalism of integral equation theory for molecular liquids (multi-center molecular Ornstein-Zernike (MC-MOZ) method). The theoretical procedure is very similar to the 3D-reference interaction site model self-consistent field (RISM-SCF) approach. Since the MC-MOZ method is highly parallelized for computation, the present approach has the potential to be one of the most efficient procedures to treat chemical processes in solution. Benchmark tests to check the validity of this approach were performed for two solute (solute water and formaldehyde) systems and a simple SN2 reaction (Cl(-) + CH3Cl → ClCH3 + Cl(-)) in aqueous solution. The results for solute molecular properties and solvation structures obtained by the present approach were in reasonable agreement with those obtained by other hybrid frameworks and experiments. In particular, the results of the proposed approach are in excellent agreements with those of 3D-RISM-SCF. PMID:26156461

  11. Spatially branched hierarchical ZnO nanorod-TiO2 nanotube array heterostructures for versatile photocatalytic and photoelectrocatalytic applications: towards intimate integration of 1D-1D hybrid nanostructures.

    PubMed

    Xiao, Fang-Xing; Hung, Sung-Fu; Tao, Hua Bing; Miao, Jianwei; Yang, Hong Bin; Liu, Bin

    2014-12-21

    Hierarchically ordered ZnO nanorods (NRs) decorated nanoporous-layer-covered TiO2 nanotube array (ZnO NRs/NP-TNTAs) nanocomposites have been prepared by an efficient, two-step anodization route combined with an electrochemical deposition strategy, by which monodispersed one-dimensional (1D) ZnO NRs were uniformly grown on the framework of NP-TNTAs. The crystal phases, morphologies, optical properties, photocatalytic as well as photoelectrocatalytic performances of the well-defined ZnO NRs/NP-TNTAs heterostructures were systematically explored to clarify the structure-property correlation. It was found that the ZnO NRs/NP-TNTAs heterostructure exhibits significantly enhanced photocatalytic and photoelectrocatalytic performances, along with favorable photostability toward degradation of organic pollutants under UV light irradiation, as compared to the single component counterparts. The remarkably enhanced photoactivity of ZnO NRs/NP-TNTAs heterostructure is ascribed to the intimate interfacial integration between ZnO NRs and NP-TNTAs substrate imparted by the unique spatially branched hierarchical structure, thereby contributing to the efficient transfer and separation of photogenerated electron-hole charge carriers. Moreover, the specific active species during the photocatalytic process was unambiguously determined and photocatalytic mechanism was tentatively presented. It is anticipated that our work could provide new insights for the construction of various hierarchical 1D-1D hybrid nanocomposites for extensive photocatalytic applications. PMID:25363649

  12. A hybrid framework of first principles molecular orbital calculations and a three-dimensional integral equation theory for molecular liquids: Multi-center molecular Ornstein-Zernike self-consistent field approach

    NASA Astrophysics Data System (ADS)

    Kido, Kentaro; Kasahara, Kento; Yokogawa, Daisuke; Sato, Hirofumi

    2015-07-01

    In this study, we reported the development of a new quantum mechanics/molecular mechanics (QM/MM)-type framework to describe chemical processes in solution by combining standard molecular-orbital calculations with a three-dimensional formalism of integral equation theory for molecular liquids (multi-center molecular Ornstein-Zernike (MC-MOZ) method). The theoretical procedure is very similar to the 3D-reference interaction site model self-consistent field (RISM-SCF) approach. Since the MC-MOZ method is highly parallelized for computation, the present approach has the potential to be one of the most efficient procedures to treat chemical processes in solution. Benchmark tests to check the validity of this approach were performed for two solute (solute water and formaldehyde) systems and a simple SN2 reaction (Cl- + CH3Cl → ClCH3 + Cl-) in aqueous solution. The results for solute molecular properties and solvation structures obtained by the present approach were in reasonable agreement with those obtained by other hybrid frameworks and experiments. In particular, the results of the proposed approach are in excellent agreements with those of 3D-RISM-SCF.

  13. Charged vanadium-benzene multidecker clusters: DFT and quantum Monte Carlo study

    NASA Astrophysics Data System (ADS)

    Tokár, K.; Derian, R.; Mitas, L.; Štich, I.

    2016-02-01

    Using explicitly correlated fixed-node quantum Monte Carlo and density functional theory (DFT) methods, we study electronic properties, ground-state multiplets, ionization potentials, electron affinities, and low-energy fragmentation channels of charged half-sandwich and multidecker vanadium-benzene systems with up to 3 vanadium atoms, including both anions and cations. It is shown that, particularly in anions, electronic correlations play a crucial role; these effects are not systematically captured with any commonly used DFT functionals such as gradient corrected, hybrids, and range-separated hybrids. On the other hand, tightly bound cations can be described qualitatively by DFT. A comparison of DFT and quantum Monte Carlo provides an in-depth understanding of the electronic structure and properties of these correlated systems. The calculations also serve as a benchmark study of 3d molecular anions that require a balanced many-body description of correlations at both short- and long-range distances.

  14. Discovering complete pressure-temperature phase diagrams with Hamiltonian Monte Carlo nested sampling

    NASA Astrophysics Data System (ADS)

    Baldock, Robert; Bernstein, Noam; Bartók-Partáy, Livia; Csányi, Gábor

    Nested sampling is a Monte Carlo algorithm that can be used to efficiently calculate the complete configurational density of states in a material that undergoes multiple first-order phase transitions. From the density of states one can calculate the partition function as an explicit function of temperature and perform statistical mechanics from first principles. Indeed, we have shown how nested sampling can be used to automatically discover complete pressure-temperature phase diagrams with no prior knowledge of the locations of phase transitions or the structures of phases. In this talk I will present a new version of the nested sampling algorithm, based on a modified Hamiltonian (``Hybrid'') Monte Carlo scheme. This new scheme reduces the scaling of a general nested sampling calculation. In particular the new algorithm expedites the sampling of atomic configuration spaces in condensed phases, and permits one to perform nested sampling calculations at a fraction of the cost required by ordinary nested sampling with standard Monte Carlo.

  15. A hybrid electron cyclotron resonance metal ion source with integrated sputter magnetron for the production of an intense Al+ ion beam

    NASA Astrophysics Data System (ADS)

    Weichsel, T.; Hartung, U.; Kopte, T.; Zschornack, G.; Kreller, M.; Philipp, A.

    2015-09-01

    A metal ion source prototype has been developed: a combination of magnetron sputter technology with 2.45 GHz electron cyclotron resonance (ECR) ion source technology—a so called magnetron ECR ion source (MECRIS). An integrated ring-shaped sputter magnetron with an Al target is acting as a powerful metal atom supply in order to produce an intense current of singly charged metal ions. Preliminary experiments show that an Al+ ion current with a density of 167 μA/cm2 is extracted from the source at an acceleration voltage of 27 kV. Spatially resolved double Langmuir probe measurements and optical emission spectroscopy were used to study the plasma states of the ion source: sputter magnetron, ECR, and MECRIS plasma. Electron density and temperature as well as Al atom density were determined as a function of microwave and sputter magnetron power. The effect of ECR heating is strongly pronounced in the center of the source. There the electron density is increased by one order of magnitude from 6 × 109 cm-3 to 6 × 1010 cm-3 and the electron temperature is enhanced from about 5 eV to 12 eV, when the ECR plasma is ignited to the magnetron plasma. Operating the magnetron at constant power, it was observed that its discharge current is raised from 1.8 A to 4.8 A, when the ECR discharge was superimposed with a microwave power of 2 kW. At the same time, the discharge voltage decreased from about 560 V to 210 V, clearly indicating a higher plasma density of the MECRIS mode. The optical emission spectrum of the MECRIS plasma is dominated by lines of excited Al atoms and shows a significant contribution of lines arising from singly ionized Al. Plasma emission photography with a CCD camera was used to prove probe measurements and to identify separated plasma emission zones originating from the ECR and magnetron discharge.

  16. Photonic integrated circuits based on silica and polymer PLC

    NASA Astrophysics Data System (ADS)

    Izuhara, T.; Fujita, J.; Gerhardt, R.; Sui, B.; Lin, W.; Grek, B.

    2013-03-01

    Various methods of hybrid integration of photonic circuits are discussed focusing on merits and challenges. Material platforms discussed in this report are mainly polymer and silica. We categorize the hybridization methods using silica and polymer waveguides into two types, chip-to-chip and on-chip integration. General reviews of these hybridization technologies from the past works are reviewed. An example for each method is discussed in details. We also discuss current status of our silica PLC hybrid integration technology.

  17. General Monte Carlo reliability simulation code including common mode failures and HARP fault/error-handling

    NASA Technical Reports Server (NTRS)

    Platt, M. E.; Lewis, E. E.; Boehm, F.

    1991-01-01

    A Monte Carlo Fortran computer program was developed that uses two variance reduction techniques for computing system reliability applicable to solving very large highly reliable fault-tolerant systems. The program is consistent with the hybrid automated reliability predictor (HARP) code which employs behavioral decomposition and complex fault-error handling models. This new capability is called MC-HARP which efficiently solves reliability models with non-constant failures rates (Weibull). Common mode failure modeling is also a specialty.

  18. Integral Data Benchmark of HENDL2.0/MG Compared with Neutronics Shielding Experiments

    NASA Astrophysics Data System (ADS)

    Jiang, Jieqiong; Xu, Dezheng; Zheng, Shanliang; He, Zhaozhong; Hu, Yanglin; Li, Jingjing; Zou, Jun; Zeng, Qin; Chen, Mingliang; Wang, Minghuang

    2009-10-01

    HENDL2.0, the latest version of the hybrid evaluated nuclear data library, was developed based upon some evaluated data from FENDL2.1 and ENDF/B-VII. To qualify and validate the working library, an integral test for the neutron production data of HENDL2.0 was performed with a series of existing spherical shell benchmark experiments (such as V, Be, Fe, Pb, Cr, Mn, Cu, Al, Si, Co, Zr, Nb, Mo, W and Ti). These experiments were simulated numerically using HENDL2.0/MG and a home-developed code VisualBUS. Calculations were conducted with both FENDL2.1/MG and FENDL2.1/MC, which are based on a continuous-energy Monte Carlo Code MCNP/4C. By comparison and analysis of the neutron leakage spectra and the integral test, benchmark results of neutron production data are presented in this paper.