Sample records for interbody fusion alif

  1. Failed anterior lumbar interbody fusion due to incomplete foraminal decompression

    Microsoft Academic Search

    Kyung-Chul Choi; Yong Ahn; Byung-Uk Kang; Joo-Hee Jang; Kyeong-Ki Kim; Yong Hwan Shin; Jong-Oh Choi; Sang-Ho Lee

    2011-01-01

    Background  Anterior lumbar interbody fusion (ALIF) has gained widespread popularity for spinal disorders requiring fusion. The purpose\\u000a of this study was to analyze ALIF failures.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  The medical records of 223 patients treated with ALIF between January 2007 and June 2008 were retrospectively reviewed. Patients\\u000a with unfavorable outcomes, including subsequent posterior decompression at the index level or poor outcomes after ALIF were

  2. A case report of a rare complication of bowel perforation in extreme lateral interbody fusion.

    PubMed

    Balsano, Massimo; Carlucci, Stefano; Ose, Marija; Boriani, Luca

    2015-04-01

    Over the past decade, extreme lateral interbody fusion (XLIF) has gained in popularity as a minimally invasive alternative to direct anterior lumbar interbody fusion (ALIF), and ALIF's associated morbidity. Most notably, XLIF largely avoids vascular and visceral structures that are required to be mobilized in ALIF. In this case report, the authors describe a rare complication of a bowel injury in a 70-year-old male who underwent an L3-4 and L4-5 lateral transpsoas approach for interbody fusion. PMID:25906377

  3. CT navigated lateral interbody fusion.

    PubMed

    Drazin, Doniel; Liu, John C; Acosta, Frank L

    2013-10-01

    Lateral interbody fusion techniques are heavily reliant on fluoroscopy for retractor docking and graft placement, which expose both the patient and surgeon to high doses of radiation. Use of image-guided technologies with CT-based images, however, can eliminate this radiation exposure for the surgeon. We describe the surgical technique of performing lateral lumbar interbody fusion using CT navigation. PMID:23931938

  4. Mini-Open Anterior Retroperitoneal Lumbar Interbody Fusion: Oblique Lateral Interbody Fusion for Lumbar Spinal Degeneration Disease

    PubMed Central

    Orita, Sumihisa; Yamauchi, Kazuyo; Eguchi, Yawara; Ochiai, Nobuyasu; Kishida, Shunji; Kuniyoshi, Kazuki; Aoki, Yasuchika; Nakamura, Junichi; Ishikawa, Tetsuhiro; Miyagi, Masayuki; Kamoda, Hiroto; Suzuki, Miyako; Kubota, Gou; Sakuma, Yoshihiro; Oikawa, Yasuhiro; Inage, Kazuhide; Sainoh, Takeshi; Sato, Jun; Fujimoto, Kazuki; Shiga, Yasuhiro; Abe, Koki; Toyone, Tomoaki; Inoue, Gen; Takahashi, Kazuhisa

    2015-01-01

    Purpose Surgery for lumbar spinal degeneration disease is widely performed. While posterior decompression and fusion are popular, anterior lumbar interbody fusion (ALIF) is also used for treatment. Extreme lateral interbody fusion (XLIF) is commonly used for noninvasive ALIF; however, several complications, such as spinal nerve and psoas muscle injury, have been reported. In the current study, we examined the clinical efficacy and complications of oblique lateral interbody fusion (OLIF) for lumbar spinal degeneration disease. Materials and Methods Thirty-five patients with degenerated spondylolisthesis, discogenic pain, and kyphoscoliosis were examined. All patients underwent OLIF surgery (using a cage and bone graft from the iliac crest) with or without posterior decompression, without real-time electromyography monitoring. Posterior screws were used in all patients. Visual analog scale (VAS) score and Oswestry Disability Index (ODI) were evaluated before and 6 months after surgery. Surgical complications were also evaluated. Results Pain scores significantly improved after surgery, compared to those before surgery (p<0.05). There was no patient who underwent revision surgery. There was no spinal nerve, major vessel, peritoneal, or urinary injury. Few patients showed symptoms from psoas invasion. Conclusion OLIF surgery produced good surgical results without any major complication. PMID:26069130

  5. Radiographic Comparison of Lateral Lumbar Interbody Fusion Versus Traditional Fusion Approaches: Analysis of Sagittal Contour Change

    PubMed Central

    Sembrano, Jonathan N.; Horazdovsky, Ryan D.; Santos, Edward Rainier G.; Polly, David W.

    2015-01-01

    Background Lateral approach to lumbar fusion has been gaining popularity in recent years. With increasing awareness of the significance of sagittal balance restoration in spinal surgery, it is important to investigate the potential of this relatively new approach in correcting sagittal deformities in comparison to conventional approaches. The aim of this study was to evaluate sagittal contour changes seen in lateral lumbar interbody fusion and compare them with radiographic changes in traditional approaches to lumbar fusion. Methods Lumbar fusion procedures from January 2008 to December 2009 were reviewed. Four approaches were compared: anterior lumbar interbody fusion (ALIF), lateral lumbar interbody fusion (LLIF), transforaminal interbody fusion (TLIF) and posterior spinal fusion (PSF). Standing pre-operative and 6-week post-operative radiographs were measured in terms of operative level, suprajacent and subjacent level, and regional lumbar lordosis (L1-S1) as well as operative level anterior (ADH) and posterior disc heights (PDH). T-test was used to analyze differences between and within different approaches (?=0.05). Results A total of 147 patients underwent lumbar fusion at 212 levels. Mean operative level segmental lordosis change after each procedure is as follows: ALIF 3.8 ± 6.6° (p < 0.01); LLIF 3.2 ± 3.6° (p<0.01); TLIF 1.9 ± 3.9° (p<0.01); and PSF 0.7 ± 2.9° (p =0.13). Overall lumbar lordosis change after each procedure is as follows: ALIF 4.2 ± 5.8° (p < 0.01); LLIF 2.5 ± 4.1° (p<0.01); TLIF 2.1 ± 6.0 (p = 0.02); PSF -0.5 ± 6.2° (p = 0.66). There were no significant changes in the supradjcent and subjacent level lordosis in all approaches except in ALIF where a significant decrease in supradjecent level lordosis was seen. Mean ADH and PDH significantly increased for all approaches except in PSF where PDH decreased post-operatively. Conclusion LLIF has the ability to improve sagittal contour as well as other interbody approaches and is superior to posterioronly approach in disc height restoration. However, ALIF provides the greatest amount of segmental and overall lumbar lordosis correction. Level of Evidence This is a Level III study. Clinical Relevance Regional lordosis correction may be effectively achieved with LLIF. This approach is a good addition to a surgeon's armamentarium in maintenance or restoration of normal lumbar sagittal alignment. PMID:26114085

  6. Mini-Open Approach for Direct Lateral Lumbar Interbody Fusion

    PubMed Central

    Chung, Sung-Soo; Pae, Young-Ryeol; Park, Se-Jun

    2014-01-01

    Study Design Retrospective analysis. Purposes To introduce the mini-open lateral approach for the anterior lumbar interbody fusion (ALIF), and to investigate the advantages, technical pitfalls and complications by providing basic knowledge on extreme lateral interbody fusion (XLIF) or direct lumbar interbody fusion (DLIF). Overview of Literature Recently, minimally invasive lateral approach for the lumbar spine is revived and receiving popularity under the name of XLIF or DLIF by modification of mini-open method when using the sequential tubular dilator and special expandable retractor system. Methods Seventy-four patients who underwent surgery by the mini-open lateral approach from September 2000 to April 2008 with various disease entities were included. Blood losses, operation times, incision sizes, postoperative time to mobilization, length of hospital stays, technical problems and complications were all analyzed. Results The blood losses and operation times of patients who underwent simple ALIF were 61.2 mL and 86 minutes for one level, 107 mL and 106 minutes for two levels, 250 mL and 142.8 minutes for three levels, and 400 mL and 190 minutes for four levels of fusion. The incision sizes were on average 4.5 cm for one level, 6.3 cm for two levels, 8.5 cm for three levels and 10.0 cm for four levels of fusion. The complications were retroperitoneal hematoma (2 cases), pneumonia (1 case) and transient lumbosacral plexus palsy (3 cases). Conclusions Trials of mini-open lateral approach would be helpful before the trial of XLIF or DLIF. However, special attention is required for complications such as transient lumbosacral plexus palsy. PMID:25187867

  7. Miniopen oblique lateral L5-s1 interbody fusion: a report of 2 cases.

    PubMed

    Kanno, Keijiro; Ohtori, Seiji; Orita, Sumihisa; Yamauchi, Kazuyo; Eguchi, Yawara; Aoki, Yasuchika; Nakamura, Junichi; Miyagi, Masayuki; Suzuki, Miyako; Kubota, Gou; Inage, Kazuhide; Sainoh, Takeshi; Sato, Jun; Shiga, Yasuhiro; Abe, Koki; Fujimoto, Kazuki; Kanamoto, Hiroto; Toyone, Tomoaki; Inoue, Gen; Hanaoka, Eiji; Takahashi, Kazuhisa

    2014-01-01

    Extreme lateral interbody fusion (XLIF) has been widely used for minimally invasive anterior lumbar interbody fusion (ALIF), but an approach to L5-S1 is difficult because of the iliac crest. In the current study, we present 2 cases using minimally invasive oblique lateral interbody fusion (OLIF) of L5-S1. The patients showed foraminal stenosis between L5 and S1 and severe low back and leg pain. The patients were placed in a lateral decubitus position and underwent OLIF surgery (using a cage and bone graft from the iliac crest) without posterior decompression. Posterior screws were used in the patients. Pain scores significantly improved after surgery. There was no spinal nerve, major vessel, peritoneal, or urinary injury. OLIF surgery was minimally invasive and produced good surgical results without complications. PMID:25400963

  8. Miniopen Oblique Lateral L5-S1 Interbody Fusion: A Report of 2 Cases

    PubMed Central

    Kanno, Keijiro; Orita, Sumihisa; Yamauchi, Kazuyo; Eguchi, Yawara; Aoki, Yasuchika; Nakamura, Junichi; Suzuki, Miyako; Kubota, Gou; Inage, Kazuhide; Sainoh, Takeshi; Sato, Jun; Abe, Koki; Kanamoto, Hiroto; Toyone, Tomoaki; Takahashi, Kazuhisa

    2014-01-01

    Extreme lateral interbody fusion (XLIF) has been widely used for minimally invasive anterior lumbar interbody fusion (ALIF), but an approach to L5-S1 is difficult because of the iliac crest. In the current study, we present 2 cases using minimally invasive oblique lateral interbody fusion (OLIF) of L5-S1. The patients showed foraminal stenosis between L5 and S1 and severe low back and leg pain. The patients were placed in a lateral decubitus position and underwent OLIF surgery (using a cage and bone graft from the iliac crest) without posterior decompression. Posterior screws were used in the patients. Pain scores significantly improved after surgery. There was no spinal nerve, major vessel, peritoneal, or urinary injury. OLIF surgery was minimally invasive and produced good surgical results without complications. PMID:25400963

  9. L5-S1 Laparoscopic Anterior Interbody Fusion

    PubMed Central

    Zeni, Tallal M.; Phillips, Frank M.; Mathur, Sameer; Zografakis, John G.; Moore, Ronald M.; Laguna, Luis E.

    2006-01-01

    Objective: We evaluated our experience with laparoscopic L5-S1 anterior lumbar interbody fusion (ALIF). Methods: This represents a retrospective analysis of consecutive patients who underwent L5-S1 laparoscopic ALIF between February 1998 and August 2003. Results: Twenty-eight patients underwent L5-S1 LAIF (15 males and 13 females). The mean age was 43 years (range, 26 to 67). Mean operative time was 225 minutes (range, 137 to 309 minutes). No conversions to an open procedure were necessary. Twenty-four (85.7%) patients underwent successful bilateral cage placement. Four patients (14.3%) in whom only a single cage could be placed underwent supplementary posterior pedicle screw placement. Mean length of stay (LOS) was 4.1 days (range, 2 to 15). Two patients underwent reoperation subacutely secondary to symptomatic lateral displacement of the cage. One patient developed radiculopathy 6 months postoperatively and required reoperation. One patient developed a small bowel obstruction secondary to adhesions to the cage requiring laparoscopic reoperation. Fusion was achieved in all patients. Visual analogue scale scores for back pain were significantly improved from 8.6±0.8 to 2.8±0.8 (P<0.0001) at 1 year. Conclusion: L5-S1 LAIF is feasible and safe with all the advantages of minimally invasive surgery. Fusion rates and pain improvement were comparable to those with an open repair. PMID:17575763

  10. Fusion after minimally disruptive anterior lumbar interbody fusion: Analysis of extreme lateral interbody fusion by computed tomography

    Microsoft Academic Search

    W. B. Rodgers; Edward J. Gerber; Jamie R. Patterson

    2010-01-01

    BackgroundLess invasive fusion approaches, such as extreme lateral interbody fusion (XLIF), have proliferated, but few reports have critically assessed fusion rates. To date, no studies have reported computed tomography (CT) documented fusion rates following XLIF.

  11. Vertebral body fracture after anterolateral instrumentation and interbody fusion in two osteoporotic patients

    Microsoft Academic Search

    Karan Dua; Christopher K. Kepler; Russel C. Huang; Anna Marchenko

    2010-01-01

    Background contextThe XLP plate is an anterolateral instrumentation system developed as a part of the eXtreme Lateral Interbody Fusion (XLIF) system for lateral transpsoas interbody fusion, an alternative to anterior interbody fusion.

  12. Presacral retroperitoneal approach to axial lumbar interbody fusion: a new, minimally invasive technique at L5-S1: Clinical outcomes, complications, and fusion rates in 50 patients at 1-year follow-up

    PubMed Central

    Bohinski, Robert J.; Jain, Viral V.; Tobler, William D.

    2010-01-01

    Background The presacral retroperitoneal approach to an axial lumbar interbody fusion (ALIF) is a percutaneous, minimally invasive technique for interbody fusion at L5-S1 that has not been extensively studied, particularly with respect to long-term outcomes. Objective The authors describe clinical and radiographic outcomes at 1-year follow-up for 50 consecutive patients who underwent the presacral ALIF. Methods Our patients included 24 males and 26 females who underwent the presacral ALIF procedure for interbody fusion at L5-S1. Indications included mechanical back pain and radiculopathy. Thirty-seven patients had disc degeneration at L5-S1, 7 had previously undergone a discectomy, and 6 had spondylolisthesis. A 2-level L4-S1 fusion was performed with a transforaminal lumbar interbody fusion at L4-5 in 15 patients. AxiaLIF was performed as a stand-alone procedure in 5 patients and supplemented with pedicle screws in 45 patients. Pre- and postoperative visual analog scale (VAS) and Oswestry Disability Index (ODI) scores were evaluated and complications were tracked. Fusion was evaluated by an independent neuro-radiologist. Results At 1-year follow-up, VAS and ODI scores had significantly improved by 49% and 50%, respectively, versus preoperative scores. By high-resolution computer tomography (CT) scans, fusion was achieved in 44 (88%) patients, developing bone occurred in 5 (10%), and 1 (2%) patient had pseudoarthrosis. One patient suffered a major operative complication–a bowel perforation with a pre-sacral abscess that resolved with treatment. Conclusion Our initial 50 patients who underwent presacral ALIF showed clinical improvement and fusion rates comparable with other interbody fusion techniques; its safety was reflected by low complication rates. Its efficacy in future patients will continue to be monitored, and will be reported in a 2-year follow-up study of fusion. PMID:25802650

  13. A comparison of perioperative charges and outcome between open and mini-open approaches for anterior lumbar discectomy and fusion

    Microsoft Academic Search

    William D. Smith; Ginger Christian; Sherrie Serrano; Kyle T. Malone

    The objectives of this study were to examine charge data and long-term outcomes of two approaches for anterior lumbar interbody fusion (IF) through retrospective chart review: a mini-open lateral interbody fusion (“XLIF”) and an Open anterior interbody fusion (ALIF). Of 202 patients who underwent one-level or two-level surgery, 87 underwent ALIF and 115 underwent XLIF, all with transpedicular fixation. Complications

  14. Endoscopic Foraminal Decompression Preceding Oblique Lateral Lumbar Interbody Fusion To Decrease The Incidence Of Post Operative Dysaesthesia

    PubMed Central

    Katzell, Jeffrey

    2014-01-01

    Background Lumbar interbody fusion has become a well established method to diminish axial back pain as well as radiculopathy in patients with degenerative disc disease, stenosis, and instability. The concept of indirect decompression of the neural foramen and spinal canal while performing fusion became popular in the mid 1990’s with description of ALIF techniques. Morphometric analysis confirmed the extent of decompression of posterior elements with interbody height restoration. In an attempt to diminish potential complications associated with anterior or posterior approaches to the spine for interbody fusion, and with the hope of accomplishing fusion in a less invasive manner, lateral lumbar interbody fusion has become quite popular. This transpsoas approach to the disc space has been associated with a high incidence of neurologic complications. Even though this is the first technique to routinely recommend EMG monitoring to increase safety in the approach, neurologic injuries still occur. A newer oblique lateral lumbar interbody (OLLIF) approach has recently been described to lessen the incidence of neurologic injury. This technique also advocates use of EMG testing to lessen neurologic trauma. In spite of this precaution, neurologic insult has not been eliminated. In fact, even in patients whose electrical stimulation thresholds suggested a safe entry space into the disc, transient dysaesthesia continues to occur in 20-25 percent of cases. Purpose This pilot study reflects data and observations of a subset of patients treated with endoscopic foraminotomy preceding oblique lateral lumbar interbody fusion (OLLIF) to assess specifically potential improvements in dysaesthesia rates. Methods A select subset of patients undergoing OLLIF failed to meet electrodiagnostic criteria for safe disc access through Kambin’s triangle. These patients underwent an endoscopic foraminotomy and exiting nerve decompression prior to discectomy, endplate preparation and cage insertion. Results Dysaesthesia did not occur in these patients whom otherwise would have likely been at risk for neurologic deficit. Conclusions These findings suggest that patients at risk for neurologic insult during oblique lateral lumbar interbody fusion can be protected by foraminoplasty. PMID:25694923

  15. Extreme Lateral Interbody Fusion (XLIF): a novel surgical technique for anterior lumbar interbody fusion

    Microsoft Academic Search

    Burak M. Ozgur; Henry E. Aryan; Luiz Pimenta; William R. Taylor

    2006-01-01

    BackgroundMinimally disruptive approaches to the anterior lumbar spine continue to evolve in a quest to reduce approach-related morbidity. A lateral retroperitoneal, trans-psoas approach to the anterior disc space allows for complete discectomy, distraction, and interbody fusion without the need for an approach surgeon.

  16. The VariLift® Interbody Fusion System: expandable, standalone interbody fusion

    PubMed Central

    Emstad, Erik; del Monaco, Diana Cardenas; Fielding, Louis C; Block, Jon E

    2015-01-01

    Intervertebral fusion cages have been in clinical use since the 1990s. Cages offer the benefits of bone graft containment, restored intervertebral and foraminal height, and a more repeatable, stable procedure compared to interbody fusion with graft material alone. Due to concerns regarding postoperative stability, loss of lordosis, and subsidence or migration of the implant, interbody cages are commonly used with supplemental fixation such as pedicle screw systems or anterior plates. While providing additional stability, supplemental fixation techniques increase operative time, exposure, cost, and morbidity. The VariLift® Interbody Fusion System (VariLift® system) has been developed as a standalone solution to provide the benefits of intervertebral fusion cages without the requirement of supplemental fixation. The VariLift® system, FDA-cleared for standalone use in both the cervical and lumbar spine, is implanted in a minimal profile and then expanded in situ to provide segmental stability, restored lordosis, and a large graft chamber. Preclinical testing and analyses have found that the VariLift® System is durable, and reduces stresses that may contribute to subsidence and migration of other standalone interbody cages. Fifteen years of clinical development with the VariLift® system have demonstrated positive clinical outcomes, continued patient maintenance of segmental stability and lordosis, and no evidence of implant migration. The purpose of this report is to describe the VariLift® system, including implant characteristics, principles of operation, indications for use, patient selection criteria, surgical technique, postoperative care, preclinical testing, and clinical experience. The VariLift® System represents an improved surgical option for a stable interbody fusion without requiring supplemental fixation.

  17. Minimally invasive transforaminal lumbar interbody fusion

    PubMed Central

    Jhala, Amit; Singh, Damandeep; Mistry, MS

    2014-01-01

    Background: The use of minimally invasive surgical (MIS) techniques represents the most recent modification of methods used to achieve lumbar interbody fusion. The advantages of minimally invasive spinal instrumentation techniques are less soft tissue injury, reduced blood loss, less postoperative pain and shorter hospital stay while achieving clinical outcomes comparable with equivalent open procedure. The aim was to study the clinicoradiological outcome of minimally invasive transforaminal lumbar interbody fusion. Materials and Methods: This prospective study was conducted on 23 patients, 17 females and 6 males, who underwent MIS-transforaminal lumbar interbody fusion (TLIF) followed up for a mean 15 months. The subjects were evaluated for clinical and radiological outcome who were manifested by back pain alone (n = 4) or back pain with leg pain (n = 19) associated with a primary diagnosis of degenerative spondylolisthesis, massive disc herniation, lumbar stenosis, recurrent disc herniation or degenerative disc disease. Paraspinal approach was used in all patients. The clinical outcome was assessed using the revised Oswestry disability index and Macnab criteria. Results: The mean age of subjects was 55.45 years. L4-L5 level was operated in 14 subjects, L5-S1 in 7 subjects; L3-L4 and double level was fixed in 1 patient each. L4-L5 degenerative listhesis was the most common indication (n = 12). Average operative time was 3 h. Fourteen patients had excellent results, a good result in 5 subjects, 2 subjects had fair results and 2 had poor results. Three patients had persistent back pain, 4 patients had residual numbness or radiculopathy. All patients had a radiological union except for 1 patient. Conclusion: The study demonstrates a good clinicoradiological outcome of minimally invasive TLIF. It is also superior in terms of postoperative back pain, blood loss, hospital stay, recovery time as well as medication use. PMID:25404767

  18. Analysis of spinal lumbar interbody fusion cage subsidence using Taguchi method, finite element analysis, and artificial neural network

    NASA Astrophysics Data System (ADS)

    Nassau, Christopher John; Litofsky, N. Scott; Lin, Yuyi

    2012-09-01

    Subsidence, when implant penetration induces failure of the vertebral body, occurs commonly after spinal reconstruction. Anterior lumbar interbody fusion (ALIF) cages may subside into the vertebral body and lead to kyphotic deformity. No previous studies have utilized an artificial neural network (ANN) for the design of a spinal interbody fusion cage. In this study, the neural network was applied after initiation from a Taguchi L 18 orthogonal design array. Three-dimensional finite element analysis (FEA) was performed to address the resistance to subsidence based on the design changes of the material and cage contact region, including design of the ridges and size of the graft area. The calculated subsidence is derived from the ANN objective function which is defined as the resulting maximum von Mises stress (VMS) on the surface of a simulated bone body after axial compressive loading. The ANN was found to have minimized the bone surface VMS, thereby optimizing the ALIF cage given the design space. Therefore, the Taguchi-FEA-ANN approach can serve as an effective procedure for designing a spinal fusion cage and improving the biomechanical properties.

  19. Instrumented Posterior Lumbar Interbody Fusion in Adult Spondylolisthesis

    PubMed Central

    Yu, Ching-Hsiao; Wang, Chen-Ti

    2008-01-01

    It is unclear whether using artificial cages increases fusion rates compared with use of bone chips alone in posterior lumbar interbody fusion for patients with lumbar spondylolisthesis. We hypothesized artificial cages for posterior lumbar interbody fusion would provide better clinical and radiographic outcomes than bone chips alone. We assumed solid fusion would provide good clinical outcomes. We clinically and radiographically followed 34 patients with spondylolisthesis having posterior lumbar interbody fusion with mixed autogenous and allogeneic bone chips alone and 42 patients having posterior lumbar interbody fusion with implantation of artificial cages packed with morselized bone graft. Patients with the artificial cage had better functional improvement in the Oswestry disability index than those with bone chips alone, whereas pain score, patient satisfaction, and fusion rate were similar in the two groups. Postoperative disc height ratio, slip ratio, and segmental lordosis all decreased at final followup in the patients with bone chips alone but remained unchanged in the artificial cage group. The functional outcome correlated with radiographic fusion status. We conclude artificial cages provide better functional outcomes and radiographic improvement than bone chips alone in posterior lumbar interbody fusion for lumbar spondylolisthesis, although both techniques achieved comparable fusion rates. Level of Evidence: Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence. PMID:18846411

  20. Oral Extrusion of Screw after Anterior Cervical Interbody Fusion

    PubMed Central

    Lee, Jin Soo; Hwang, Soo Hyun; Han, Jong Woo

    2008-01-01

    We present a case of delayed oral extrusion of a screw after anterior cervical interbody fusion in a 68-year-old man with osteoporosis. Fifteen months earlier, he had undergone C5 corpectomy and anterior cervical interbody fusion at C4-6 for multiple spinal stenoses. The patient was nearly asymptomatic, except for a foreign body sensation in his throat. We conclude that the use of a mesh graft or other instrument in elderly patients and those with osteoporosis or problematic bone quality should be considered carefully and that if surgery were to be performed, periodic postoperative follow-up evaluations are mandatory. PMID:19096688

  1. Comparison of Transforaminal Lumbar Interbody Fusion with Direct Lumbar Interbody Fusion: Clinical and Radiological Results

    PubMed Central

    Lee, Young Seok; Park, Seung Won; Chung, Chan

    2014-01-01

    Objective The use of direct lumbar interbody fusion (DLIF) has gradually increased; however, no studies have directly compared DLIF and transforaminal lumbar interbody fusion (TLIF). We compared DLIF and TLIF on the basis of clinical and radiological outcomes. Methods A retrospective review was performed on the medical records and radiographs of 98 and 81 patients who underwent TLIF and DLIF between January 2011 and December 2012. Clinical outcomes were compared with a visual analog scale (VAS) and the Oswestry disability index (ODI). The preoperative and postoperative disc heights, segmental sagittal/coronal angles, and lumbar lordosis were measured on radiographs. Fusion rates, operative time, estimated blood loss (EBL), length of hospital stay, and complications were assessed. Results DLIF was superior to TLIF regarding its ability to restore disc height, foraminal height, and coronal balance (p<0.001). As the extent of surgical level increased, DLIF displayed significant advantages over TLIF considering the operative time and EBL. However, fusion rates at 12 months post-operation were lower for DLIF (87.8%) than for TLIF (98.1%) (p=0.007). The changes of VAS and ODI between the TLIF and DLIF were not significantly different (p>0.05). Conclusion Both DLIF and TLIF are less invasive and thus good surgical options for treating degenerative lumber diseases. DLIF has higher potential in increasing neural foramina and correcting coronal balance, and involves a shorter operative time and reduced EBL, in comparison with TLIF. However, DLIF displayed a lower fusion rate than TLIF, and caused complications related to the transpsoas approach. PMID:25628805

  2. Posterior interbody fusion using laminectomy bone and transpedicular screw fixation in the treatment of lumbar spondylolisthesis

    Microsoft Academic Search

    György I Csécsei; Álmos P Klekner; József Dobai; Attila Lajgut; Judit Sikula

    2000-01-01

    BACKGROUNDLaminectomy bone is used widely in posterolateral lumbar fusion, but not interbody fusion. No prospective evaluation of interbody fusion using bone grafts from the posterior neural arch in spondylolisthesis has been found in the literature. We prospectively studied series of patients operated on for lumbar spondylolisthesis to evaluate clinical improvement and bony fusion.METHODSForty-six patients were operated on for lumbar spondylolisthesis

  3. Clinical outcome of stand-alone ALIF compared to posterior instrumentation for degenerative disc disease: A pilot study and a literature review.

    PubMed

    Udby, Peter M; Bech-Azeddine, Rachid

    2015-06-01

    The objective of the article was to: a) present results from a case cohort pilot study comparing stand-alone ALIF and TLIF and, b) review the literature on studies comparing the clinical outcome of stand-alone ALIF with posterior instrumentation including TLIF or PLIF, in patients with disabling low back pain resulting from degenerative disc disease. ALIF surgery has previously been linked with certain high risk complications and unfavorable long term fusion results. Newer studies suggest that stand-alone ALIF can possibly be advantageous compared to other types of posterior instrumented interbody fusion for a selected group of DDD patients. The methods and material consisted of a cohort pilot study of patients, with DDD treated with stand-alone ALIF or TLIF followed by a literature review conducted through a comprehensive PubMed database search of the English literature. Studies comparing stand-alone ALIF with posterior instrumented interbody fusion were selected and reviewed. Results from the pilot study, n = 21, showed a reduced perioperative blood loss, shorter operative time and a trend towards better pain reduction and decreased use of opioid analgesics in patients undergoing stand-alone ALIF compared to posterior instrumented fusion with TLIF. The literature review included three studies, n = 630. All three studies were retrospective cohort studies. The average patient follow-up was 2-years but with heterogeneous selected outcomes. Two of three articles documented significant advantages when using stand-alone ALIF on outcomes such as ODI, VAS, surgical time, blood loss and patient satisfaction. No study found stand-alone ALIF inferior in chosen outcomes including fusion. In conclusion the pilot study and the literature review, finds similar clinical outcomes and fusion rates after stand-alone ALIF and posterior interbody fusion. Stand-alone ALIF was associated with a shorter duration of surgery, less perioperative blood loss and a faster improvement post-operatively. Therefore stand-alone ALIF is a viable and important surgical option, which could be considered first choice as surgical treatment. PMID:25855474

  4. Subsidence of metal interbody cage after posterior lumbar interbody fusion with pedicle screw fixation.

    PubMed

    Tokuhashi, Yasuaki; Ajiro, Yasumitsu; Umezawa, Natsuki

    2009-04-01

    Posterior lumbar interbody fusion is considered to be an excellent fusion procedure to stabilize anterior support, correct alignment in the sagittal and coronal plane, and achieve foraminal decompression by lifting the disk height. The metal interbody cage in posterior lumbar interbody fusion is thought to be useful to prevent collapse of the graft bone and to correct and maintain disk height; however, some studies have noted a gradual decrease of disk height due to cage subsidence. Therefore, to investigate the significance of cage subsidence, 86 disk levels radiographically confirmed to have good union in 66 patients with posterior lumbar interbody fusion combined with pedicle screw fixation and a single metal cage for degenerative lumbar disease were retrospectively evaluated. The follow-up period ranged from 3 years to 10 years 3 months, with a mean of 7 years 9 months. Cage subsidence often showed a gradual increase over time. At final follow-up, subsidence averaged 4.0 mm on the cranial surface and 2.7 mm on the caudal surface. Although the average increase of disk height was 3.2 mm immediately postoperatively, the final disk height decreased by 4.2 mm on average from that time. The degree of cage subsidence and decrease of disk height were not correlated with the final clinical results. Subsidence was not correlated with bone mineral density in the vertebral body, body weight, or site of the insertion. On the other hand, the wedge shape of the cage and the thickness of the resected endplate had a significant influence on cage subsidence. PMID:19388615

  5. Biomechanical comparison of two different concepts for stand alone anterior lumbar interbody fusion.

    PubMed

    Schleicher, Philipp; Gerlach, R; Schär, B; Cain, C M J; Achatz, W; Pflugmacher, R; Haas, N P; Kandziora, F

    2008-12-01

    Segmental instability in degenerative disc disease is often treated with anterior lumbar interbody fusion (ALIF). Current techniques require an additional posterior approach to achieve sufficient stability. The test device is an implant which consists of a PEEK-body and an integrated anterior titanium plate hosting four diverging locking screws. The test device avoids posterior fixation by enhancing stability via the locking screws. The test device was compared to an already established stand alone interbody implant in a human cadaveric three-dimensional stiffness test. In the biomechanical test, the L4/5 motion segment of 16 human cadaveric lumbar spines were isolated and divided into two test groups. Tests were performed in flexion, extension, right and left lateral bending, right and left axial rotation. Each specimen was tested in native state first, then a discectomy was performed and either of the test implants was applied. Finite element analysis (FE) was also performed to investigate load and stress distribution within the implant in several loading conditions. The FE models simulated two load cases. These were flexion and extension with a moment of 5 Nm. The biomechanical testing revealed a greater stiffness in lateral bending for the SynFix-LR compared to the established implant. Both implants showed a significantly higher stiffness in all loading directions compared to the native segment. In flexion loading, the PEEK component takes on most of the load, whereas the majority of the extension load is put on the screws and the screw-plate junction. Clinical investigation of the test device seems reasonable based on the good results reported here. PMID:18841399

  6. Biomechanical comparison of two different concepts for stand alone anterior lumbar interbody fusion

    PubMed Central

    Gerlach, R.; Schär, B.; Cain, C. M. J.; Achatz, W.; Pflugmacher, R.; Haas, N. P.; Kandziora, F.

    2008-01-01

    Segmental instability in degenerative disc disease is often treated with anterior lumbar interbody fusion (ALIF). Current techniques require an additional posterior approach to achieve sufficient stability. The test device is an implant which consists of a PEEK-body and an integrated anterior titanium plate hosting four diverging locking screws. The test device avoids posterior fixation by enhancing stability via the locking screws. The test device was compared to an already established stand alone interbody implant in a human cadaveric three-dimensional stiffness test. In the biomechanical test, the L4/5 motion segment of 16 human cadaveric lumbar spines were isolated and divided into two test groups. Tests were performed in flexion, extension, right and left lateral bending, right and left axial rotation. Each specimen was tested in native state first, then a discectomy was performed and either of the test implants was applied. Finite element analysis (FE) was also performed to investigate load and stress distribution within the implant in several loading conditions. The FE models simulated two load cases. These were flexion and extension with a moment of 5 Nm. The biomechanical testing revealed a greater stiffness in lateral bending for the SynFix-LR™ compared to the established implant. Both implants showed a significantly higher stiffness in all loading directions compared to the native segment. In flexion loading, the PEEK component takes on most of the load, whereas the majority of the extension load is put on the screws and the screw–plate junction. Clinical investigation of the test device seems reasonable based on the good results reported here. PMID:18841399

  7. Biomechanical Characteristics of an Integrated Lumbar Interbody Fusion Device

    PubMed Central

    Voronov, Leonard I.; Vastardis, Georgios; Zelenakova, Julia; Carandang, Gerard; Havey, Robert M.; Waldorff, Erik I.; Zindrick, Michael R.

    2014-01-01

    Introduction We hypothesized that an Integrated Lumbar Interbody Fusion Device (PILLAR SA, Orthofix, Lewisville, TX) will function biomechanically similar to a traditional anterior interbody spacer (PILLAR AL, Orthofix, Lewisville, TX) plus posterior instrumentation (FIREBIRD, Orthofix, Lewisville, TX). Purpose of this study was to determine if an Integrated Interbody Fusion Device (PILLAR SA) can stabilize single motion segments as well as an anterior interbody spacer (PILLAR AL) + pedicle screw construct (FIREBIRD). Methods Eight cadaveric lumbar spines (age: 43.9±4.3 years) were used. Each specimen's range of motion was tested in flexion-extension (FE), lateral bending (LB), and axial rotation (AR) under intact condition, after L4-L5 PILLAR SA with intervertebral screws and after L4-L5 360° fusion (PILLAR AL + Pedicle Screws and rods (FIREBIRD). Each specimen was tested in flexion (8Nm) and extension (6Nm) without preload (0 N) and under 400N of preload, in lateral bending (±6 Nm) and axial rotation (±5 Nm) without preload. Results Integrated fusion using the PILLAR SA device demonstrated statistically significant reductions in range of motion of the L4-L5 motion segment as compared to the intact condition for each test direction. PILLAR SA reduced ROM from 8.9±1.9 to 2.9±1.1° in FE with 400N follower preload (67.4%), 8.0±1.7 to 2.5±1.1° in LB, and 2.2±1.2 to 0.7±0.3° in AR. A comparison between the PILLAR SA integrated fusion device versus 360° fusion construct with spacer and bilateral pedicle screws was statistically significant in FE and LB. The 360° fusion yielded motion of 1.0±0.5° in FE, 1.0±0.8° in LB (p0.05). Conclusions The PILLAR SA resulted in motions of less than 3° in all modes of motion and was not as motion restricting as the traditional 360° using bilateral pedicle screws. The residual segmental motions compare very favorably with published biomechanical studies of other interbody integrated fusion devices. PMID:25694931

  8. Anterior discectomy without interbody fusion for cervical disc herniation

    Microsoft Academic Search

    V. Pointillart; A. Cernier; J. M. Vital; J. Senegas

    1995-01-01

    Between 1985 and 1990, 68 patients with cervical radiculopathy due to soft disc herniation were treated by anterior cervical discectomy without interbody fusion. Eleven patients were unavailable for follow-up examination. The mean follow-up was 23 months (range 12–54 months). Both clinical and radiographic follow-ups were done, and 92% of the patients was found to have excellent or good clinical results.

  9. Lateral transpsoas lumbar interbody fusion: outcomes and deformity correction.

    PubMed

    Dahdaleh, Nader S; Smith, Zachary A; Snyder, Laura A; Graham, Randall B; Fessler, Richard G; Koski, Tyler R

    2014-04-01

    The lateral transpsoas approach for interbody fusion is a minimally invasive technique that has been gaining increasing popularity in the management of a variety of spinal degenerative disorders. Recently, there has been increasing utilization of this technique in the management of adult deformity. The authors present a review of the current evidence of using the lateral lumbar transpsoas approach in the correction of adult degenerative scoliosis. PMID:24703453

  10. Large volume inside the cage leading incomplete interbody bone fusion and residual back pain after posterior lumbar interbody fusion.

    PubMed

    Takeuchi, Mikinobu; Kamiya, Mitsuhiro; Wakao, Norimitsu; Hirasawa, Atsuhiko; Kawanami, Katsuhisa; Osuka, Koji; Takayasu, Masakazu

    2015-07-01

    The purpose of this study is to compare intervertebral bone fusion and clinical outcomes in L4-5 posterior lumbar interbody fusion (PLIF) using the same posterior instrumentation with four combinations of one of three types of interbody cage with one of two bone grafts, iliac and local or only local. In 67 patients who underwent L4-5 PLIF, 19 patients had the Brantigan cage and iliac and local bone graft, 18 with the TELAMON C cage and iliac and local bone graft, 16 with the TELAMON C cage and local bone graft (TL), and 14 with the OIC PEEK cage and local bone graft. Clinical assessments were based on Japanese Orthopaedic Association (JOA) scores and on the visual analogue scale (VAS). The bone fusion assessments were based on radiography and CT scans according to the Brantigan, Steffee, and Fraser criteria. More than 2 years after surgery, these assessments were made. In the results, the fusion outcome for the group receiving TL was significantly less than those for the other three groups. In TL, multivariate logistic regression analysis showed that the inside volume of the cage of ?2.0 mL was the only significant factor for incomplete fusion. Moreover, the VAS (low back pain) score was significantly higher for TL than for the other three groups. In conclusions, we believe that the large volume inside the cage (?2.0 mL) with local bone graft may lead incomplete interbody bone fusion and residual postsurgical low back pain after PLIF. PMID:25666390

  11. Interobserver agreement using computed tomography to assess radiographic fusion criteria with a unique titanium interbody device.

    PubMed

    Slosar, Paul J; Kaiser, Jay; Marrero, Luis; Sacco, Damon

    2015-02-01

    The accuracy of using computed tomography (CT) to assess interbody fusion in patients with titanium implants has been questioned in the past. Radiologists have reported difficulty assessing fusion bone quality because of metal artifact and small graft windows. A new titanium interbody implant with a large footprint and a wide graft aperture has been developed. We conducted a study to determine the interobserver reliability of using CT to assess radiographic fusion variables with the new titanium interbody device. Patients underwent anterior lumbar interbody fusion with the same titanium interbody implant. Reconstructed CT images were obtained randomly at 6, 9, or 12 months. Two independent radiologists reviewed the scans. Interobserver reliability was calculated using the ? statistic. Fifty-six spinal fusion levels (33 patients) were analyzed. The radiologists agreed on 345 of the 392 fusion data points reviewed (? = .88). Agreement for solid fusion formation was 0.77. This interbody device demonstrated minimal artifact and minimal subsidence, and trabecular bone was easily identified throughout the implant in the vast majority of cases reviewed. High interobserver agreement was noted across all radiographic variables assessed. PMID:25658078

  12. Posterior lumbar interbody fusion using one diagonal fusion cage with transpedicular screw\\/rod fixation

    Microsoft Academic Search

    Jie Zhao; Tiesheng Hou; Xinwei Wang; Shengzhong Ma

    2003-01-01

    Posterior lumbar interbody fusion (PLIF) using threaded cages has gained wide popularity for lumbosacral spinal disease. Our biomechanical tests showed that PLIF using a single diagonal cage with unilateral facetectomy does add a little to spinal stability and provides equal or even higher postoperative stability than PLIF using two posterior cages with bilateral facetectomy. Studies also demonstrated that cages placed

  13. Does anterior lumbar interbody fusion promote adjacent degeneration in degenerative disc disease? A finite element study

    Microsoft Academic Search

    Shujie Tang; Brandon J. Rebholz

    2011-01-01

    Background  The increase in the number of anterior lumbar interbody fusions being performed carries with it the potential for the long-term\\u000a complication of adjacent segmental degeneration. While its exact mechanism remains uncertain, adjacent segment degeneration\\u000a has become much more widespread. Using a nonlinear, three-dimensional finite element model to analyze and compare the biomechanical\\u000a influence of anterior lumbar interbody fusion and lumbar

  14. [Biomechanical research of transforaminal lumbar interbody fusion model].

    PubMed

    Yan, Wentoa; Zhao, Gaiping; Fang, Xinguo; Guo, Haoxiang; Ma, Tong; Tu, Yihui

    2015-02-01

    Based on the surgical model using transforaminal lumbar interbody fusion (TLIF) to treat lumbar spondylolisthesis, this paper presents the investigations of the biomechanical characteristics of cage and pedicle screw in lumbar spinal fusion implant fixed system under different combinations with finite element method. Firstly, combining the CT images with finite element pretreatment software, we established three dimensional nonlinear finite element model of human lumbar L4-L5 segmental slight slippage and implant under different fixed combinations. We then made a comparison analysis between the biomechanical characteristics of lumbar motion range, stress distribution of cage and pedicle screw under six status of each model which were flexion, extension, left lateral bending, right lateral bending, left axial rotation and right axial rotation. The results showed that the motion ranges of this model under different operations were reduced above 84% compared with those of the intact model, and the stability of the former was improved significantly. The stress values of cage and pedicle screw were relatively larger when they were fixed by single fusion device additional unilateral pedicle screw, but there was no statistically significant difference. The above research results would provide reference and confirmation for further biomechanics research of TLIF extracorporal specimens, and finally provide biomechanical basis for the feasibility of unilateral internal fixed diagonal intervertebral fusion TLIF surgery. PMID:25997268

  15. Biological performance of a polycaprolactone-based scaffold used as fusion cage device in a large animal model of spinal reconstructive surgery

    Microsoft Academic Search

    Sunny A. Abbah; Christopher X. L. Lam; Dietmar W. Hutmacher; James C. H. Goh; Hee-Kit Wong

    2009-01-01

    A bioactive and bioresorbable scaffold fabricated from medical grade poly (epsilon-caprolactone) and incorporating 20% beta-tricalcium phosphate (mPCL–TCP) was recently developed for bone regeneration at load bearing sites. In the present study, we aimed to evaluate bone ingrowth into mPCL–TCP in a large animal model of lumbar interbody fusion. Six pigs underwent a 2-level (L3\\/4; L5\\/6) anterior lumbar interbody fusion (ALIF)

  16. Subsidence of stand-alone cervical cages in anterior interbody fusion: warning

    Microsoft Academic Search

    Erol Gercek; Vincent Arlet; Josee Delisle; Dante Marchesi

    2003-01-01

    Anterior cervical decompression and fusion with anterior plating of the cervical spine is a well-accepted treatment for cervical radiculopathy. Recently, to minimise the extent of surgery, anterior interbody fusion with cages has become more common. While there are numerous reports on the primary stabilising effects of the different cervical cages, little is known about the subsidence behaviour of such cages

  17. Direct Lateral Lumbar Interbody Fusion: Clinical and Radiological Outcomes

    PubMed Central

    Lee, Young Seok; Kim, Young Baeg

    2014-01-01

    Objective According to the recent development of minimally invasive spinal surgery, direct lumbar interbody fusion (DLIF) was introduced as an effective option to treat lumbar degenerative diseases. However, comprehensive results of DLIF have not been reported in Korea yet. The object of this study is to summarize radiological and clinical outcomes of our DLIF experience. Methods We performed DLIF for 130 patients from May 2011 to June 2013. Among them, 90 patients, who could be followed up for more than 6 months, were analyzed retrospectively. Clinical outcomes were compared using visual analog scale (VAS) score and Oswestry Disability Index (ODI). Bilateral foramen areas, disc height, segmental coronal and sagittal angle, and regional sagittal angle were measured. Additionally, fusion rate was assessed. Results A total of 90 patients, 116 levels, were underwent DLIF. The VAS and ODI improved statistically significant after surgery. All the approaches for DLIF were done on the left side. The left and right side foramen area changed from 99.5 mm2 and 102.9 mm2 to 159.2 mm2 and 151.2 mm2 postoperatively (p<0.001). Pre- and postoperative segmental coronal and sagittal angles changed statistically significant from 4.1° and 9.9° to 1.1° and 11.1°. Fusion rates of 6 and 12 months were 60.9% and 87.8%. Complications occurred in 17 patients (18.9%). However, most of the complications were resolved within 2 months. Conclusion DLIF is not only effective for indirect decompression and deformity correction but also shows satisfactory mechanical stability and fusion rate. PMID:25132930

  18. Minimally invasive versus open transforaminal lumbar interbody fusion

    PubMed Central

    Villavicencio, Alan T.; Roeca, Cassandra M.; Nelson, E. Lee; Mason, Alexander

    2010-01-01

    Background Available clinical data are insufficient for comparing minimally invasive (MI) and open approaches for transforaminal lumbar interbody fusion (TLIF). To date, a paucity of literature exists directly comparing minimally invasive (MI) and open approaches for transforaminal lumbar interbody fusion (TLIF). The purpose of this study was to directly compare safety and effectiveness for these two surgical approaches. Materials and Methods Open or minimally invasive TLIF was performed in 63 and 76 patients, respectively. All consecutive minimally invasive TLIF cases were matched with a comparable cohort of open TLIF cases using three variables: diagnosis, number of spinal levels, and history of previous lumbar surgery. Patients were treated for painful degenerative disc disease with or without disc herniation, spondylolisthesis, and/or stenosis at one or two spinal levels. Clinical outcome (self-report measures, e.g., visual analog scale (VAS), patient satisfaction, and MacNab's criteria), operative data (operative time, estimated blood loss), length of hospitalization, and complications were assessed. Average follow-up for patients was 37.5 months. Results: The mean change in VAS scores postoperatively was greater (5.2 vs. 4.1) in theopen TLIF patient group (P = 0.3). MacNab's criteria score was excellent/good in 67% and 70% (P = 0.8) of patients in open and minimally invasive TLIF groups, respectively. The overall patient satisfaction was 72.1% and 64.5% (P = 0.4) in open and minimally invasive TLIF groups, respectively. The total mean operative time was 214.9 min for open and 222.5 min for minimally invasive TLIF procedures (P = 0.5). The mean estimated blood loss for minimally invasive TLIF (163.0 ml) was significantly lower (P < 0.0001) than the open approach (366.8 ml). The mean duration of hospitalization in the minimally invasive TLIF (3 days) was significantly shorter (P = 0.02) than the open group (4.2 days). The total rate of neurological deficit was 10.5% in the minimally invasive TLIF group compared to 1.6% in the open group (P = 0.02). Conclusions: Minimally invasive TLIF technique may provide equivalent long-term clinical outcomes compared to open TLIF approach in select population of patients. The potential benefit of minimized tissue disruption, reduced blood loss, and length of hospitalization must be weighted against the increased rate of neural injury-related complications associated with a learning curve. PMID:20657693

  19. Viscoelastic Disc Arthroplasty Provides Superior Back and Leg Pain Relief in Patients with Lumbar Disc Degeneration Compared to Anterior Lumbar Interbody Fusion

    PubMed Central

    Rischke, Burkhard; Smith, Eric

    2015-01-01

    Background Lumbar disc degeneration (LDD) is one of the most frequently diagnosed spinal diseases. The symptoms these disorders cause are anticipated to increase as the population in Western countries ages. Purpose Compare back and leg pain alleviation in patients with LDD and a viscoelastic disc prosthesis documented in the SWISSspine registry versus patients with anterior lumbar interbody fusion documented in the Spine Tango registry. Study Design Prospectively collected clinical and outcome data in two independent spine registries. Outcome Measures were back and leg pain relief on 0 to 10 numerical rating scales. Materials and Methods The analysis included a single surgeon series of 48 patients with viscoelastic total disc replacement (VTDR) from the SWISSspine registry which were compared to 131 patients with anterior lumbar interbody fusion (ALIF) from the Spine Tango registry. Two linear multivariate regression models were built to assess the associations of patient characteristics with back and leg pain relief. The following covariates were included in the models: patient age and sex, disc herniation as additional diagnosis, number of treated segments, level of treated segment, treatment type (VTDR, ALIF), preoperative back and leg pain levels and follow-up interval. Results Both models showed VTDR to be associated with significantly higher back (2.76 points; 95% confidence interval (CI) 1.78 - 3.73; p < 0.001) and leg pain (2.12 points; 95% CI 1.12 to 3.13; p < 0.001) relief than ALIF. Other influential factors for higher back pain relief were female sex compared with male sex (1.03 additional points; 95% CI 0.27 to 1.78; p = 0.008), monosegmental surgery compared with bisegmental surgery (1.02 additional points; 95% CI 0.21 to 1.83; p = 0.014), and higher back pain at baseline (0.87 points additional pain relief per level of preoperative back pain; 95% CI 0.70 to 1.03; p < 0.001). Other influential factors for leg pain relief were monosegmental surgery (0.93 additional points; 95% CI 0.10 to 1.77; p = 0.029) and higher leg pain at baseline (0.83 points additional pain relief per level of preoperative leg pain; 95% CI 0.70 to 0.96). In both models the L3/4 segment showed 2.36 points (95% CI -4.27 to -0.45; p = 0.016) and 3.69 points (95% CI -5.66 to -1.71; p < 0.001) less pain relief than L5/S1. Discussion Significantly higher back and leg pain relief were observed after viscoelastic total disc replacement in comparison with anterior lumbar interbody fusion. The new less rigid materials used in the second generation total disc replacements (TDRs) may make artificial disc replacement an increasingly attractive option for patients with degenerative lumbar disc disease. Further controlled and long-term follow-up studies are required for more detailed comparisons of the outcomes of these types of disc implants. The Freedom Lumbar Disc is limited by U.S. federal law to investigational use only. PMID:26196033

  20. Endovascular embolization of iatrogenic lumbar artery pseudoaneurysm following extreme lateral interbody fusion (XLIF).

    PubMed

    Santillan, Alejandro; Patsalides, Athos; Gobin, Y Pierre

    2010-10-01

    Iatrogenic lumbar artery pseudoaneurysm is a very rare complication of spinal surgery. To the best of our knowledge, this is the first report of a lumbar artery pseudoaneurysm after extreme lateral interbody fusion (XLIF). The lesion was diagnosed by catheter spinal angiography and was effectively treated with embolization. PMID:20675335

  1. Allograft Cellular Bone Matrix in Extreme Lateral Interbody Fusion: Preliminary Radiographic and Clinical Outcomes

    PubMed Central

    Tohmeh, Antoine G.; Watson, Blake; Tohmeh, Mirna; Zielinski, Xavier J.

    2012-01-01

    Introduction. Extreme lateral interbody fusion (XLIF) is a minimally disruptive alternative for anterior lumbar interbody fusion. Recently, synthetic and allograft materials have been increasingly used to eliminate donor-site pain and complications secondary to autogenous bone graft harvesting. The clinical use of allograft cellular bone graft has potential advantages over autograft by eliminating the need to harvest autograft while mimicking autograft's biologic function. The objective of this study was to examine 12-month radiographic and clinical outcomes in patients who underwent XLIF with Osteocel Plus, one such allograft cellular bone matrix. Methods. Forty (40) patients were treated at 61 levels with XLIF and Osteocel Plus and included in the analysis. Results. No complications were observed. From preoperative to 12-month postoperative followup, ODI improved 41%, LBP improved 55%, leg pain improved 43.3%, and QOL (SF-36) improved 56%. At 12 months, 92% reported being “very” or “somewhat” satisfied with their outcome and 86% being either “very” or “somewhat likely” to choose to undergo the procedure again. Complete fusion was observed in 90.2% (55/61) of XLIF levels. Conclusions. Complete interbody fusion with Osteocel Plus was shown in 90.2% of XLIF levels, with the remaining 9.8% being partially consolidated and progressing towards fusion at 12 months. PMID:23251099

  2. Lateral Interbody Fusion for Treatment of Discogenic Low Back Pain: Minimally Invasive Surgical Techniques

    PubMed Central

    Marchi, Luis; Oliveira, Leonardo; Amaral, Rodrigo; Castro, Carlos; Coutinho, Thiago; Coutinho, Etevaldo; Pimenta, Luiz

    2012-01-01

    Low back pain is one of the most common ailments in the general population, which tends to increase in severity along with aging. While few patients have severe enough symptoms or underlying pathology to warrant surgical intervention, in those select cases treatment choices remain controversial and reimbursement is a substancial barrier to surgery. The object of this study was to examine outcomes of discogenic back pain without radiculopathy following minimally-invasive lateral interbody fusion. Twenty-two patients were treated at either one or two levels (28 total) between L2 and 5. Discectomy and interbody fusion were performed using a minimallyinvasive retroperitoneal lateral transpsoas approach. Clinical and radiographic parameters were analyzed at standard pre- and postoperative intervals up to 24 months. Mean surgical duration was 72.1 minutes. Three patients underwent supplemental percutaneous pedicle screw instrumentation. Four (14.3%) stand-alone levels experienced cage subsidence. Pain (VAS) and disability (ODI) improved markedly postoperatively and were maintained through 24 months. Segmental lordosis increased significantly and fusion was achieved in 93% of levels. In this series, isolated axial low back pain arising from degenerative disc disease was treated with minimally-invasive lateral interbody fusion in significant radiographic and clinical improvements, which were maintained through 24 months. PMID:22548181

  3. Contralateral femoral nerve compression: An unrecognized complication after extreme lateral interbody fusion (XLIF)

    Microsoft Academic Search

    Ioannis D. Papanastassiou; Mohammad Eleraky; Frank D. Vrionis

    2011-01-01

    Extreme lateral interbody fusion (XLIF) is a relatively new procedure for the treatment of degenerative disc disease avoiding the morbidity of anterior approaches. Ipsilateral L2–5 nerve root irritation and injury are well-described complications. We describe two patients with contralateral extremity symptoms, not reported so far. In the first patient the injury was caused by a displaced endplate fragment compressing the

  4. Anterior Interbody Fusion with the BAK-Cage in Cervical Spondylosis

    Microsoft Academic Search

    G. Matge

    1998-01-01

    Summary   BAK-C is a new autostabilizing interbody cage which is implanted during an anterior cervical procedure to provide stability\\u000a to the motion segment and allow fusion to occur. Special intrumentation is provided with a bone collecting reamer. The system\\u000a utilizes surgical site bone graft as the osteo-inductive material within the implant.\\u000a \\u000a Biomechanical testing indicates improved stability and animal studies show

  5. Clinical Outcome and Fusion Rates after the First 30 Extreme Lateral Interbody Fusions

    PubMed Central

    Malham, Gregory M.; Ellis, Ngaire J.; Parker, Rhiannon M.; Seex, Kevin A.

    2012-01-01

    Introduction. The lateral transpsoas approach for lumbar interbody fusion (XLIF) is gaining popularity. Studies examining a surgeon's early experience are rare. We aim to report treatment, complication, clinical, and radiographic outcomes in an early series of patients. Methods. Prospective data from the first thirty patients treated with XLIF by a single surgeon was reviewed. Outcome measures included pain, disability, and quality of life assessment. Radiographic assessment of fusion was performed by computed tomography. Results. Average follow-up was 11.5 months, operative time was 60 minutes per level and blood loss was 50?mL. Complications were observed: clinical subsidence, cage breakage upon insertion, new postoperative motor deficit and bowel injury. Approach side-effects were radiographic subsidence and anterior thigh sensory changes. Two patients required reoperation; microforaminotomy and pedicle screw fixation respectively. VAS back and leg pain decreased 63% and 56%, respectively. ODI improved 41.2% with 51.3% and 8.1% improvements in PCS and MCS. Complete fusion (last follow-up) was observed in 85%. Conclusion. The XLIF approach provides superior treatment, clinical outcomes and fusion rates compared to conventional surgical approaches with lowered complication rates. Mentor supervision for early cases and strict adherence to the surgical technique including neuromonitoring is essential. PMID:23213282

  6. Contralateral femoral nerve compression: An unrecognized complication after extreme lateral interbody fusion (XLIF).

    PubMed

    Papanastassiou, Ioannis D; Eleraky, Mohammad; Vrionis, Frank D

    2011-01-01

    Extreme lateral interbody fusion (XLIF) is a relatively new procedure for the treatment of degenerative disc disease avoiding the morbidity of anterior approaches. Ipsilateral L2-5 nerve root irritation and injury are well-described complications. We describe two patients with contralateral extremity symptoms, not reported so far. In the first patient the injury was caused by a displaced endplate fragment compressing the contralateral nerve root; in the second patient, the injury resulted from a far-lateral herniation after the XLIF procedure. Both patients experienced resolution of their symptoms after being reoperated. Overall, this complication was encountered in 2/32 levels treated during the study period. Overzealous endplate removal and breaking of the osteophytes in the opposite corner of the intervertebral disc, although desirable for maximal coronal deformity correction, may lead to irritation of the contralateral nerve roots. Attention is needed especially where the interbody cage is placed posteriorly or diagonally towards the neuralforamen. PMID:20965732

  7. Caudal Vertebral Body Fractures Following Lateral Interbody Fusion in Nonosteoporotic Patients

    PubMed Central

    Tender, Gabriel C.

    2014-01-01

    Background The minimally invasive lateral transpsoas approach for lumbar fusions has become increasingly popular. However, vertebral body fractures have been reported after this procedure, particularly in patients with osteoporosis and patients undergoing multilevel fusions. We evaluated the risk factors for caudal vertebral body fractures in 2 nonosteoporotic patients with single-level disease. Case Reports Two patients presented with several years' history of incapacitating chronic low back pain and intermittent radicular pain. Diagnostic imaging in both cases demonstrated grade 1 degenerative spondylolisthesis. The patients underwent a lateral transpsoas interbody fusion, with lateral plate fixation in 1 patient and standalone lateral fusion in the other. The operations were performed without any incidents and both patients experienced immediate symptom relief. Both patients returned several weeks later with excruciating low back pain, without any postoperative history of trauma or heavy lifting. Diagnostic imaging in both patients showed a coronal fracture of the inferior vertebral body. The patients underwent urgent revision surgery involving posterior supplementation with pedicle screw and rod constructs and posterolateral fusion. Conclusion Caudal vertebral body fracture in patients with normal bone quality is a major potential complication after the minimally invasive lateral approach for lumbar fusions. Risk factors may include placement of a lateral plate, the size of the smaller anteroposterior cage, endplate violation, and oblique placement of the interbody cage. PMID:24688345

  8. Complete cage migration/subsidence into the adjacent vertebral body after posterior lumbar interbody fusion.

    PubMed

    Corniola, Marco V; Jägersberg, Max; Stienen, Martin N; Gautschi, Oliver P

    2015-03-01

    A variety of implant-related short and long-term complications after lumbar fusion surgery are recognized. Mid to long-term complications due to cage migration and/or cage subsidence are less frequently reported. Here, we report a patient with a complete cage migration into the superior adjacent vertebral body almost 20 years after the initial posterior lumbar interbody fusion procedure. In this patient, the cage migration/subsidence was clinically silent, but a selective decompression for adjacent segment degenerative lumbar spinal stenosis was performed. We discuss the risk factors for cage migration/subsidence in view of the current literature. PMID:25455736

  9. Clinical and Radiological Outcomes of Anterior Cervical Interbody Fusion Using Hydroxyapatite Spacer

    PubMed Central

    Kim, Sung Chul; Kang, Sung Won; Kim, Se Hyuk; Cho, Ki Hong

    2009-01-01

    Objective This is retrospective study of clinical and radiological outcomes of anterior cervical fusion using Bongros-HA™ (BioAlpha, Seongnam, Korea) which is a type of synthetic hydroxyapatite (HA) spacer to evaluate the efficacy in its clinical application and usefulness as a reliable alternative to autograft bone. Methods Twenty-nine patients were enrolled in this study and 40 segments were involved. All patients were performed anterior cervical interbody fusion using HA spacer and plating system. Indications for surgery were radiculopathy caused by soft-disc herniation or spondylosis in 18 patients, spondylotic myelopathy in 1 patient, and spinal trauma in 10 patients. Cervical spine radiographs were obtained on postoperative 1day, 1week, and then at 1, 2, 6, and 12 months in all patients to evaluate intervertebral disc height, and the degrees of lordosis. Cervical computed tomography was done at postoperative 12 month in all patients to confirm the fusion status. The mean period of clinical follow-up was 17 months. Results Complete interbody fusion was achieved in 100% of patients. Preoperative kyphotic deformities were corrected in all cases after surgery. Intervertebral disc height was well maintained during follow up period. There were no cases of graft extrusion, graft deterioration and graft fracture. Conclusion HA spacer is very efficient in achieving cervical fusion, maintaining intervertebral disc height, and restoring lordosis. When combined with the placement of a cervical plate, immediate stability can be achieved and graft related complication can be prevented. PMID:19893716

  10. Does Transforaminal Lumbar Interbody Fusion Have Advantages over Posterolateral Lumbar Fusion for Degenerative Spondylolisthesis?

    PubMed

    Fujimori, Takahito; Le, Hai; Schairer, William W; Berven, Sigurd H; Qamirani, Erion; Hu, Serena S

    2015-04-01

    Study Design?Retrospective cohort study. Objective?To compare the clinical and radiographic outcomes of transforaminal lumbar interbody fusion (TLIF) and posterolateral lumbar fusion (PLF) in the treatment of degenerative spondylolisthesis. Methods?This study compared 24 patients undergoing TLIF and 32 patients undergoing PLF with instrumentation. The clinical outcomes were assessed by visual analog scale (VAS) for low back pain and leg pain, physical component summary (PCS) of the 12-item Short-Form Health Survey, and the Oswestry Disability Index (ODI). Radiographic parameters included slippage of the vertebra, local disk lordosis, the anterior and posterior disk height, lumbar lordosis, and pelvic parameters. Results?The improvement of VAS of leg pain was significantly greater in TLIF than in PLF unilaterally (3.4 versus 1.0; p?=?0.02). The improvement of VAS of low back pain was significantly greater in TLIF than in PLF (3.8 versus 2.2; p?=?0.02). However, there was no significant difference in improvement of ODI or PCS between TLIF and PLF. Reduction of slippage and the postoperative disk height was significantly greater in TLIF than in PLF. There was no significant difference in local disk lordosis, lumbar lordosis, or pelvic parameters. The fusion rate was 96% in TLIF and 84% in PLF (p?=?0.3). There was no significant difference in fusion rate, estimated blood loss, adjacent segmental degeneration, or complication rate. Conclusions?TLIF was superior to PLF in reduction of slippage and restoring disk height and might provide better improvement of leg pain. However, the health-related outcomes were not significantly different between the two procedures. PMID:25844282

  11. Stand-Alone Lateral Interbody Fusion for the Treatment of Low-Grade Degenerative Spondylolisthesis

    PubMed Central

    Marchi, Luis; Abdala, Nitamar; Oliveira, Leonardo; Amaral, Rodrigo; Coutinho, Etevaldo; Pimenta, Luiz

    2012-01-01

    The purpose of this paper was to investigate the stand-alone lateral interbody fusion as a minimally invasive option for the treatment of low-grade degenerative spondylolisthesis with a minimum 24-month followup. Prospective nonrandomized observational single-center study. 52 consecutive patients (67.6 ± 10?y/o; 73.1% female; 27.4 ± 3.4?BMI) with single-level grade I/II single-level degenerative spondylolisthesis without significant spine instability were included. Fusion procedures were performed as retroperitoneal lateral transpsoas interbody fusions without screw supplementation. The procedures were performed in average 73.2 minutes and with less than 50cc blood loss. VAS and Oswestry scores showed lasting improvements in clinical outcomes (60% and 54.5% change, resp.). The vertebral slippage was reduced in 90.4% of cases from mean values of 15.1% preoperatively to 7.4% at 6-week followup (P < 0.001) and was maintained through 24 months (7.1%, P < 0.001). Segmental lordosis (P < 0.001) and disc height (P < 0.001) were improved in postop evaluations. Cage subsidence occurred in 9/52 cases (17%) and 7/52 cases (13%) spine levels needed revision surgery. At the 24-month evaluation, solid fusion was observed in 86.5% of the levels treated. The minimally invasive lateral approach has been shown to be a safe and reproducible technique to treat low-grade degenerative spondylolisthesis. PMID:22545019

  12. Complications and perioperative factors associated with learning the technique of minimally invasive transforaminal lumbar interbody fusion (TLIF)

    Microsoft Academic Search

    Darryl Lau; Jasmine G. Lee; Seunggu J. Han; Daniel C. Lu; Dean Chou

    2011-01-01

    Before the advent of minimally invasive spine surgery (MIS), open transforaminal lumbar interbody fusion (TLIF) was performed to treat spondylosis, spondylolisthesis, and spondylolysis. Minimally invasive TLIF has recently become more popular based upon the premise that a smaller, less traumatic incision should afford better recovery and outcomes. However, the learning curve associated with this technique must be considered. To analyze

  13. Evaluation of autologous bone marrow mesenchymal stem cell-calcium phosphate ceramic composite for lumbar fusion in rhesus monkey interbody fusion model.

    PubMed

    Wang, Tao; Dang, Gengting; Guo, Zhaoqing; Yang, Min

    2005-01-01

    Autologous bone marrow mesenchymal stem cell (BMSC)-calcium phosphate ceramic composites were constructed in vitro and implanted as a bone graft substitute for lumbar anterior interbody fusion in rhesus monkeys to determine the osteogenic capacity of the composites. Nine adult rhesus monkeys underwent lumbar L3-L4 and L5-L6 diskectomy and interbody fusion via an anterior retroperitoneal approach. Two fusion sites in each animal were randomly assigned to two of three treatments: autogenous tricortical iliac crest bone graft (autograft group), cell-free ceramic graft (ceramic group), or BMSC-ceramic composite graft (BMSC group). Autologous BMSCs were expanded in culture and stimulated with osteogenic supplement. The spinal fusion segments were evaluated by radiography, biomechanical testing, histologic analysis, and histomorphometric analysis 3 months postsurgery. The BMSC group achieved lumbar interbody fusion superior to that of the ceramic group, both biomechanically and histologically. The BMSC group and the autograft group showed equivalent biomechanical stiffness. Ceramic residues were significantly greater in the ceramic group versus the BMSC group. The results indicate that BMSC-ceramic composites can enhance bone regeneration and achieve osseous spinal fusion 3 months after implantation in the rhesus monkey interbody fusion model. PMID:16144452

  14. Lumbar Lateral Interbody Fusion (LLIF): Comparative Effectiveness and Safety versus PLIF/TLIF and Predictive Factors Affecting LLIF Outcome

    PubMed Central

    Barbagallo, Giuseppe M. V.; Albanese, Vincenzo; Raich, Annie L.; Dettori, Joseph R.; Sherry, Ned; Balsano, Massimo

    2014-01-01

    Study Design?Systematic review. Study Rationale?The surgical treatment of adult degenerative lumbar conditions remains controversial. Conventional techniques include posterior lumbar interbody fusion (PLIF) or transforaminal lumbar interbody fusion (TLIF). A new direct approach known as lumbar lateral interbody fusion (LLIF), or extreme lateral interbody fusion (XLIF®) or direct lateral interbody fusion (DLIF), has been introduced. Objectives?The objective of this article is to determine the comparative effectiveness and safety of LLIF, at one or more levels with or without instrumentation, versus PLIF or TLIF surgery in adults with lumbar degenerative conditions, and to determine which preoperative factors affect patient outcomes following LLIF surgery. Materials and Methods?A systematic review of the literature was performed using PubMed and bibliographies of key articles. Articles were reviewed by two independent reviewers based on predetermined inclusion and exclusion criteria. Each article was evaluated using a predefined quality rating scheme. Results?The search yielded 258 citations and the following met our inclusion criteria: three retrospective cohort studies (all using historical cohorts) (class of evidence [CoE] III) examining the comparative effectiveness and safety of LLIF/XLIF®/DLIF versus PLIF or TLIF surgery, and one prospective cohort study (CoE II) and two retrospective cohort studies (CoE III) assessing factors affecting patient outcome following LLIF. Patients in the LLIF group experienced less estimated blood loss and a lower mortality risk compared with the PLIF group. The number of levels treated and the preoperative diagnosis were significant predictors of perioperative or early complications in two studies. Conclusion?There is insufficient evidence of the comparative effectiveness of LLIF versus PLIF/TLIF surgery. There is low-quality evidence suggesting that LLIF surgery results in fewer complications or reoperations than PLIF/TLIF surgery. And there is insufficient evidence that any preoperative factors exist that predict patient outcome after LLIF surgery. PMID:24715870

  15. Clinical Outcomes of Extreme Lateral Interbody Fusion in the Treatment of Adult Degenerative Scoliosis

    PubMed Central

    Caputo, Adam M.; Michael, Keith W.; Chapman, Todd M.; Massey, Gene M.; Howes, Cameron R.; Isaacs, Robert E.; Brown, Christopher R.

    2012-01-01

    Introduction. The use of extreme lateral interbody fusion (XLIF) and other lateral access surgery is rapidly increasing in popularity. However, limited data is available regarding its use in scoliosis surgery. The objective of this study was to evaluate the clinical outcomes of adults with degenerative lumbar scoliosis treated with XLIF. Methods. Thirty consecutive patients with adult degenerative scoliosis treated by a single surgeon at a major academic institution were followed for an average of 14.3 months. Interbody fusion was completed using the XLIF technique with supplemental posterior instrumentation. Validated clinical outcome scores were obtained on patients preoperatively and at most recent follow-up. Complications were recorded. Results. The study group demonstrated improvement in multiple clinical outcome scores. Oswestry Disability Index scores improved from 24.8 to 19.0 (P?

  16. Protecting the genitofemoral nerve during direct/extreme lateral interbody fusion (DLIF/XLIF) procedures.

    PubMed

    Jahangiri, Faisal R; Sherman, Jonathan H; Holmberg, Andrea; Louis, Robert; Elias, Jeff; Vega-Bermudez, Francisco

    2010-12-01

    A 77-year-old male presented with a history of severe lower back pain for 10 years with radiculopathy, positive claudication type symptoms in his calf with walking, and severe "burning" in his legs bilaterally with walking. Magnetic resonance imaging (MRI) revealed lumbar stenosis at the L3-L4 and L4-L5 levels. During the direct or extreme lateral interbody fusion (DLIF/XLIF) procedure, bilateral posterior tibial, femoral, and ulnar nerve somatosensory evoked potentials (SSEPs) were recorded with good morphology of waveforms observed. Spontaneous electromyography (S-EMG) and triggered electromyography (T-EMG) were recorded from cremaster and ipsilateral leg muscles. A left lateral retroperitoneal transpsoas approach was used to access the anterior disc space for complete discectomy, distraction, and interbody fusion. T-EMG ranging from 0.05 to 55.0 mA with duration of 200 microsec was used for identification of the genitofemoral nerve using a monopolar stimulator during the approach. The genitofemoral nerve (L1-L2) was identified, and the guidewire was redirected away from the nerve. Post-operatively, the patient reported complete pain relief and displayed no complications from the procedure. Intraoperative SSEPs, S-EMG, and T-EMG were utilized effectively to guide the surgeon's approach in this DLIF thereby preventing any post-operative neurological deficits such as damage to the genitofemoral nerve that could lead to groin pain. PMID:21313792

  17. Stand-alone minimally invasive lateral lumbar interbody fusion: multicenter clinical outcomes.

    PubMed

    Ahmadian, Amir; Bach, Konrad; Bolinger, Bryan; Malham, Gregory M; Okonkwo, David O; Kanter, Adam S; Uribe, Juan S

    2015-04-01

    Stand-alone minimally invasive lateral transpsoas interbody fusion (MIS-LIF), without posterior instrumentation, is feasible because the technique does not necessitate the disruption of the stabilizing elements. The objectives of this study are to evaluate the efficacy and clinical outcomes of patients who underwent stand-alone lateral interbody fusion. A multicenter chart review was conducted to identify patients who underwent stand-alone MIS-LIF between 2008 and 2012. Patients were classified by spinal pathology (degenerative disc disease [DDD], spondylolisthesis [SL] and adult degenerative scoliosis [ADS]). Routine clinical follow-up was scheduled at 3, 6, and12 months. Outcome measures included hospital length of stay, fusion rates, neurologic complications, integrity of construct and clinical outcome questionnaires (Visual Analog Scale [VAS] and Oswestry Disability Index [ODI]). A total of 59 patients met the inclusion criteria. The average age was 60 years (range 31-86 years). Spinal pathologies treated were DDD in 37 (63%), SL in four (7%) and ADS in 18 (30%) patients. Fusion rate was 93% of patients (95% of levels) at 12 months. Two patients required re-operation. Mean hospital stay and follow-up were 3.3days (range 1-10) and 14.6 months, respectively. The mean preoperative VAS and ODI were 69.1 and 51.8, respectively. VAS improved to 37.8 (p<0.0005). ODI improved to 31.8 (p<0.0005). Seventy percent of patients had grade 0 subsidence while 30% had grade I and grade II subsidence. Stand-alone MIS-LIF is viable option in a carefully selected patient population for both single and multilevel disease and shows significant improvement in health related quality of life. PMID:25684343

  18. Anterior column realignment following lateral interbody fusion for sagittal deformity correction.

    PubMed

    Pimenta, Luiz; Fortti, Fernanda; Oliveira, Leonardo; Marchi, Luis; Jensen, Rubens; Coutinho, Etevaldo; Amaral, Rodrigo

    2015-07-01

    Degenerative and iatrogenic diseases may lead to loss of lordosis or even kyphotic thoracolumbar deformity and sagittal misalignment. Traditional surgery with three-column osteotomies is associated with important neurologic risks and postoperative morbidity. In a novel technique, the lateral transpsoas interbody fusion (LTIF) is complemented with the sacrifice of the anterior longitudinal ligament and anterior portion of the annulus followed by the insertion of a hyperlordotic interbody cage. This is a less invasive lateral technique named anterior column realignment (ACR) and aims to correct sagittal misalignment in adult spinal deformity (ASD), with or without the addition of minor posterior osteotomies. In this article, we provide an account of the evolution to the ACR technique, the literature, and the Brazilian experience in the treatment of adult spinal deformity with this novel advanced application of LTIF. In the presence of ASD, the risk-to-benefit ratio of a surgical correction must be evaluated. Less invasive surgical strategies can be alternatives to treat the deformity and provide better quality of life to the patient. ACR is an advanced application of lateral transpsoas approach, up to date has shown to be reliable and effective when used for ASD, and may minimize complications and morbidity from traditional surgical procedures. Long-term follow-up and comparative studies are needed to evaluate real benefit. PMID:25971442

  19. Hybrid Biosynthetic Autograft Extender for Use in Posterior Lumbar Interbody Fusion: Safety and Clinical Effectiveness

    PubMed Central

    Chedid, Mokbel K; Tundo, Kelly M; Block, Jon E; Muir, Jeffrey M

    2015-01-01

    Autologous iliac crest bone graft is the preferred option for spinal fusion, but the morbidity associated with bone harvest and the need for graft augmentation in more demanding cases necessitates combining local bone with bone substitutes. The purpose of this study was to document the clinical effectiveness and safety of a novel hybrid biosynthetic scaffold material consisting of poly(D,L-lactide-co-glycolide) (PLGA, 75:25) combined by lyophilization with unmodified high molecular weight hyaluronic acid (10-12% wt:wt) as an extender for a broad range of spinal fusion procedures. We retrospectively evaluated all patients undergoing single- and multi-level posterior lumbar interbody fusion at an academic medical center over a 3-year period. A total of 108 patients underwent 109 procedures (245 individual vertebral levels). Patient-related outcomes included pain measured on a Visual Analog Scale. Radiographic outcomes were assessed at 6 weeks, 3-6 months, and 1 year postoperatively. Radiographic fusion or progression of fusion was documented in 221 of 236 index levels (93.6%) at a mean (±SD) time to fusion of 10.2+4.1 months. Single and multi-level fusions were not associated with significantly different success rates. Mean pain scores (+SD) for all patients improved from 6.8+2.5 at baseline to 3.6+2.9 at approximately 12 months. Improvements in VAS were greatest in patients undergoing one- or two-level fusion, with patients undergoing multi-level fusion demonstrating lesser but still statistically significant improvements. Overall, stable fusion was observed in 64.8% of vertebral levels; partial fusion was demonstrated in 28.8% of vertebral levels. Only 15 of 236 levels (6.4%) were non-fused at final follow-up

  20. Multilevel extreme lateral interbody fusion (XLIF) and osteotomies for 3-dimensional severe deformity: 25 consecutive cases

    PubMed Central

    McAfee, Paul C.; Shucosky, Erin; Chotikul, Liana; Salari, Ben; Chen, Lun; Jerrems, Dan

    2013-01-01

    Background This is a retrospective review of 25 patients with severe lumbar nerve root compression undergoing multilevel anterior retroperitoneal lumbar interbody fusion and posterior instrumentation for deformity. The objective is to analyze the outcomes and clinical results from anterior interbody fusions performed through a lateral approach and compare these with traditional surgical procedures. Methods A consecutive series of 25 patients (78 extreme lateral interbody fusion [XLIF] levels) was identified to illustrate the primary advantages of XLIF in correcting the most extreme of the 3-dimensional deformities that fulfilled the following criteria: (1) a minimum of 40° of scoliosis; (2) 2 or more levels of translation, anterior spondylolisthesis, and lateral subluxation (subluxation in 2 planes), causing symptomatic neurogenic claudication and severe spinal stenosis; and (3) lumbar hypokyphosis or flat-back syndrome. In addition, the majority had trunks that were out of balance (central sacral vertical line ?2 cm from vertical plumb line) or had sagittal imbalance, defined by a distance between the sagittal vertical line and S1 of greater than 3 cm. There were 25 patients who had severe enough deformities fulfilling these criteria that required supplementation of the lateral XLIF with posterior osteotomies and pedicle screw instrumentation. Results In our database, with a mean follow-up of 24 months, 85% of patients showed evidence of solid arthrodesis and no subsidence on computed tomography and flexion/extension radiographs. The complication rate remained low, with a perioperative rate of 2.4% and postoperative rate of 12.2%. The lateral listhesis and anterior spondylolisthetic subluxation were anatomically reduced with minimally invasive XLIF. The main finding in these 25 cases was our isolation of the major indication for supplemental posterior surgery: truncal decompensation in patients who are out of balance by 2 cm or more, in whom posterior spinal osteotomies and segmental pedicle screw instrumentation were required at follow up. No patients were out of sagittal balance (sagittal vertical line <3 cm from S1) postoperatively. Segmental instrumentation with osteotomies was also more effective for restoration of physiologic lumbar lordosis compared with anterior stand-alone procedures. Conclusions This retrospective study supports the finding that clinical outcomes (coronal/sagittal alignment) improve postoperatively after minimally invasive surgery with multilevel XLIF procedures and are improved compared with larger extensile thoracoabdominal anterior scoliosis procedures. PMID:25694908

  1. Postoperative Flat Back: Contribution of Posterior Accessed Lumbar Interbody Fusion and Spinopelvic Parameters

    PubMed Central

    Kim, Jin Kwon; Kim, Deok Ryeng; Kim, Joo Seung

    2014-01-01

    Objective Posterior accessed lumbar interbody fusion (PALIF) has a clear objective to restore disc height and spinal alignment but surgeons may occasionally face the converse situation and lose lumbar lordosis. We analyzed retrospective data for factors contributing to a postoperative flat back. Methods A total of 105 patients who underwent PALIF for spondylolisthesis and stenosis were enrolled. The patients were divided according to surgical type [posterior lumbar inter body fusion (PLIF) vs. unilateral transforaminal lumbar interbody fusion (TLIF)], number of levels (single vs. multiple), and diagnosis (spondylolisthesis vs. stenosis). We measured perioperative index level lordosis, lumbar lordosis, pelvic tilt, sacral slope, pelvic incidence, and disc height in standing lateral radiographs. The change and variance in each parameter and comparative group were analyzed with the paired and Student t-test (p<0.05), correlation coefficient, and regression analysis. Results A significant perioperative reduction was observed in index-level lordosis following TLIF at the single level and in patients with spondylolisthesis (p=0.002, p=0.005). Pelvic tilt and sacral slope were significantly restored following PLIF multilevel surgery (p=0.009, p=0.003). Sacral slope variance was highly sensitive to perioperative variance of index level lordosis in high sacral sloped pelvis. Perioperative variance of index level lordosis was positively correlated with disc height variance (R2=0.286, p=0.0005). Conclusion Unilateral TLIF has the potential to cause postoperative flat back. PLIF is more reliable than unilateral TLIF to restore spinopelvic parameters following multilevel surgery and spondylolisthesis. A high sacral sloped pelvis is more vulnerable to PALIF in terms of a postoperative flat back. PMID:25371781

  2. Extreme lateral interbody fusion for the treatment of adult degenerative scoliosis.

    PubMed

    Caputo, Adam M; Michael, Keith W; Chapman, Todd M; Jennings, Jason M; Hubbard, Elizabeth W; Isaacs, Robert E; Brown, Christopher R

    2013-11-01

    Extreme lateral interbody fusion (XLIF; NuVasive Inc., San Diego, CA, USA) is a minimally invasive lateral transpsoas approach to the thoracolumbar spine. Though the procedure is rapidly increasing in popularity, limited data is available regarding its use in deformity surgery. We aimed to evaluate radiographic correction using XLIF in adults with degenerative lumbar scoliosis. Thirty consecutive patients were followed for an average of 14.3 months. Interbody fusion was completed using the XLIF technique with supplemental posterior instrumentation. Plain radiographs were obtained on all patients preoperatively, postoperatively, and at most recent follow-up. Plain radiographic measurements of coronal Cobb angle, apical vertebral translation, segmental lordosis, global lordosis, disc height, neuroforaminal height and neuroforaminal width were made at each time point. CT scans were obtained for all patients 1 year after surgery to evaluate for fusion. There was significant improvement in multiple radiographic parameters from preoperative to postoperative. Cobb angle corrected 72.3%, apical vertebral translation corrected 59.7%, neuroforaminal height increased 80.3%, neuroforaminal width increased 7.4%, and disc height increased 116.7%. Segmental lordosis at L4-L5 increased 14.1% and global lordosis increased 11.5%. There was no significant loss of correction from postoperative to most recent follow-up. There was an 11.8% pseudoarthrosis rate at levels treated with XLIF. Complications included lateral incisional hernia (n=1), rupture of anterior longitudinal ligament (n=2), wound breakdown (n=2), cardiac instability (n=1), pedicle fracture (n=1), and nonunion requiring revision (n=1). XLIF significantly improves coronal plane deformity in patients with adult degenerative scoliosis. XLIF has the ability to correct sagittal plane deformity, although it is most effective at lower lumbar levels. PMID:23906522

  3. 9:34 Comparison of impacted femoral ring allografts, threaded cortical bone dowels and titanium cages in lumbar fusion

    Microsoft Academic Search

    Kenneth Burkus; John Dorchak

    2002-01-01

    Purpose of study: To test the efficacy of recombinant human bone morphogenic protein (rhBMP-2), we compared clinical and radiographic outcomes in patients who underwent a single-level anterior lumbar interbody fusion (ALIF) and were treated with impacted femoral rings and autogenous bone graft, threaded cortical allograft dowels or titanium cages. Patients who received dowels or titanium cages were randomized to receive

  4. Endoscopic transforaminal decompression, interbody fusion, and percutaneous pedicle screw implantation of the lumbar spine: A case series report

    PubMed Central

    Osman, Said G.

    2012-01-01

    Background On the basis of the experiences gained from conventional open spinal procedures, a long list of desirable objectives have emerged with the evolution of the lesser invasive spinal procedures. At the top of that list is the desire to minimize the trauma of surgery. The rest of the objectives, which include reductions of operating time, surgical blood loss, hospital stay, postoperative narcotic medication, convalescence, complication rates, and escalating health care costs, as well as the desire of elderly patients to continue rigorous physical activities, largely depend on the ability to minimize the trauma of surgery. The purpose of this study was to investigate the feasibility of the least invasive lumbar decompression, interbody fusion and percutaneous pedicle screw implantation, to minimize surgical trauma without compromising the quality of the treatment outcome, as well as to minimize risk of complications. Methods In this case series, 60 patients with diagnoses of degenerative disc disease, degenerative motion segments with stenosis, and spondylolisthesis, in whom nonoperative treatments failed, were treated with endoscopic transforaminal decompression and interbody fusion by 1 surgeon in 2 centers. The outcome measures were as follows: operating time, intraoperative blood loss, hospital stay, Visual Analogue Scale (VAS) scores for back and leg pain, scores on the Roland-Morris Disability Questionnaire, and postoperative imaging studies. A consecutive series of patients who met the treatment criteria completed VAS forms and Roland-Morris questionnaires preoperatively. Surgical procedures included arthroscopic decompression of the foramina and the discs; endplate preparation and implantation of allograft bone chips and bone morphogenetic protein 2 on absorbable collagen sponge into the disc space; and percutaneous implantation of pedicle screws. Postoperatively, the patients again completed the VAS forms and Roland-Morris questionnaires. Their charts were reviewed for office notes, operative notes, hospital stay, medications, and imaging studies. The latest X-ray and computed tomography scan films were reviewed and analyzed. Patients were followed up for a minimum of 6 months. The literature was reviewed for comparison of outcomes. Results Sixty patients met the inclusion criteria. The mean age was 52.8 years. The duration of illness averaged 5 years. Follow-up ranged from 6 to 25 months, with a mean of 12 months. Preoperative diagnoses included degenerative disc disease, degenerative motion segments with stenosis, and spondylolisthesis. The mean time in the operating room was 2 hours 54 minutes. Estimated blood loss averaged 57.6 mL. The duration of the hospital stay averaged 2.6 days. Preoperative back pain and leg pain were significantly reduced (P < .005). Forty-seven imaging studies obtained at the last visit, including X-ray and computed tomography scans, showed solid fusion in 28 patients (59.6%), stable fixation in 17 (36.2%), and osteolysis around the pedicle screws in 2 (4.2%). All patients had improvement of motor function, whereas 2 patients complained of residual numbness. In addition, 8 patients (13%) complained of residual discomfort on extension of the lumbar spine. Two patients had pedicle screw–related complications requiring surgery. A review of the literature showed that endoscopic transforaminal decompression and interbody fusion performed better than open transforaminal lumbar interbody fusion/posterior lumbar interbody fusion, minimally invasive transforaminal lumbar interbody fusion, and extreme lateral lumbar interbody fusion, with regard to most parameters studied. Conclusions The endoscopic transforaminal lumbar decompression, interbody fusion, and percutaneous pedicle screw instrumentation consistently produced satisfactory results in all demographics. It performed better than the alternative procedures for most parameters studied. PMID:25694885

  5. Navigation-assisted fluoroscopy in minimally invasive direct lateral interbody fusion: a cadaveric study

    PubMed Central

    Webb, Jonathan E.; Regev, Gilad J.; Garfin, Steven R.; Kim, Choll W.

    2010-01-01

    Background Minimally invasive surgery (MIS) is dependent on intraoperative fluoroscopic imaging for visualization, which significantly increases exposure to radiation. Navigation-assisted fluoroscopy (NAV) can potentially decrease radiation exposure and improve the operating room environment by reducing the need for real-time fluoroscopy. The direct lateral interbody fusion (DLIF) procedure is a technique for MIS intervertebral lumbar and thoracic interbody fusions. This study assesses the use of navigation for the DLIF procedure in comparison to standard fluoroscopy (FLUORO), as well as the accuracy of the NAV MIS DLIF procedure. Methods Three fresh whole-body cadavers underwent multiple DLIF procedures at the T10-L5 levels via either NAV or FLUORO. Radiation exposure and surgical times were recorded and compared between groups. An additional cadaver was used to evaluate the accuracy of the NAV system for the DLIF procedure by measuring the deviation error as the surgeon worked further from the anterior superior iliac spine tracker. Results Approach, discectomy, and total fluoroscopy times for FLUORO were longer than NAV (P < .05). In contrast, the setup time was longer in NAV (P = .005). Cage insertion and total operating times were similar for both. Radiation exposure to the surgeon for NAV was significantly less than FLUORO (P < .05). Accuracy of the NAV system was within 1 mm for L2-5. Conclusion Navigation for the DLIF procedure is feasible. Accuracy for this procedure over the most common levels (L2-5) is likely sufficient for safe clinical application. Although initial setup times were longer with NAV, simultaneous anteroposterior and lateral imaging with the NAV system resulted in overall surgery times similar to FLUORO. Navigation minimizes fluoroscopic radiation exposure. Clinical significance Navigation for the DLIF procedure is accurate and decreases radiation exposure without increasing the overall surgical time. PMID:25802659

  6. Minimally invasive presacral approach for revision of an Axial Lumbar Interbody Fusion rod due to fall-related lumbosacral instability: a case report

    PubMed Central

    2011-01-01

    Introduction The purpose of this study was to describe procedural details of a minimally invasive presacral approach for revision of an L5-S1 Axial Lumbar Interbody Fusion rod. Case presentation A 70-year-old Caucasian man presented to our facility with marked thoracolumbar scoliosis, osteoarthritic changes characterized by high-grade osteophytes, and significant intervertebral disc collapse and calcification. Our patient required crutches during ambulation and reported intractable axial and radicular pain. Multi-level reconstruction of L1-4 was accomplished with extreme lateral interbody fusion, although focal lumbosacral symptoms persisted due to disc space collapse at L5-S1. Lumbosacral interbody distraction and stabilization was achieved four weeks later with the Axial Lumbar Interbody Fusion System (TranS1 Inc., Wilmington, NC, USA) and rod implantation via an axial presacral approach. Despite symptom resolution following this procedure, our patient suffered a fall six weeks postoperatively with direct sacral impaction resulting in symptom recurrence and loss of L5-S1 distraction. Following seven months of unsuccessful conservative care, a revision of the Axial Lumbar Interbody Fusion rod was performed that utilized the same presacral approach and used a larger diameter implant. Minimal adhesions were encountered upon presacral re-entry. A precise operative trajectory to the base of the previously implanted rod was achieved using fluoroscopic guidance. Surgical removal of the implant was successful with minimal bone resection required. A larger diameter Axial Lumbar Interbody Fusion rod was then implanted and joint distraction was re-established. The radicular symptoms resolved following revision surgery and our patient was ambulating without assistance on post-operative day one. No adverse events were reported. Conclusions The Axial Lumbar Interbody Fusion distraction rod may be revised and replaced with a larger diameter rod using the same presacral approach. PMID:21959081

  7. Posterior lumbar interbody fusion and posterolateral fusion: Analogous procedures in decreasing the index of disability in patients with spondylolisthesis

    PubMed Central

    Alijani, Babak; Emamhadi, Mohamahreza; Behzadnia, Hamid; Aramnia, Ali; Chabok, Shahrokh Yousefzadeh; Ramtinfar, Sara; Leili, Ehsan Kazemnejad; Golmohamadi, Shabnam

    2015-01-01

    Objective: The purpose of this study was to evaluate the disability in patients with spondylolisthesis who assigned either to posterolateral fusion (PLF) or posterior lumbar interbody fusion (PLIF) and to compare it between two groups. Methods: In a prospective observational study, 102 surgical candidates with low-grade degenerative and isthmic spondylolisthesis enrolled from 2012 to 2014, and randomly assigned into two groups: PLF and PLIF. Evaluation of disability has been done by a questionnaire using Oswestry Disability Index (ODI). The questionnaire was completed by all patients before the surgery, the day after surgery, after 6 months and after 1-year. Results: There were no statistically significant differences in terms of age and sex distribution and pre-operation ODI between groups (P > 0.05). Comparison of the mean ODI scores of two groups over the whole study period showed no significant statistical difference (P = 0.074). ODIs also showed no significant differences between two groups the day after surgery, 6th months and 1-year after surgery (P = 0.385, P = 0.093, P = 0.122 and P = 433) respectively. Analyzing the course of ODI over the study period, showed a significant descending pattern for either of groups (P < 0.0001). Conclusion: Both surgical fusion techniques (PLF and PLIF) were efficient to lessen the disability of patients with spondylolisthesis, and none of the fusion techniques were related to a better outcome in terms of disability. PMID:25767584

  8. Accidental Durotomy in Minimally Invasive Transforaminal Lumbar Interbody Fusion: Frequency, Risk Factors, and Management

    PubMed Central

    Volz, Florian; Krüger, Marie T.; Kogias, Evangelos; Rölz, Roland; Sircar, Ronen; Hubbe, Ulrich

    2015-01-01

    Purpose. To assess the frequency, risk factors, and management of accidental durotomy in minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). Methods. This single-center study retrospectively investigates 372 patients who underwent MIS TLIF and were mobilized within 24 hours after surgery. The frequency of accidental durotomies, intraoperative closure technique, body mass index, and history of previous surgery was recorded. Results. We identified 32 accidental durotomies in 514 MIS TLIF levels (6.2%). Analysis showed a statistically significant relation of accidental durotomies to overweight patients (body mass index ?25?kg/m2; P = 0.0493). Patient age older than 65 years tended to be a positive predictor for accidental durotomies (P = 0.0657). Mobilizing patients on the first postoperative day, we observed no durotomy-associated complications. Conclusions. The frequency of accidental durotomies in MIS TLIF is low, with overweight being a risk factor for accidental durotomies. The minimally invasive approach seems to minimize durotomy-associated complications (CSF leakage, pseudomeningocele) because of the limited dead space in the soft tissue. Patients with accidental durotomy can usually be mobilized within 24 hours after MIS TLIF without increased risk. The minimally invasive TLIF technique might thus be beneficial in the prevention of postoperative immobilization-associated complications such as venous thromboembolism. This trial is registered with DRKS00006135.

  9. Intraoperative reversal of neuromuscular block with sugammadex or neostigmine during extreme lateral interbody fusion, a novel technique for spine surgery

    Microsoft Academic Search

    Milan Adamus; Lumir Hrabalek; Tomas Wanek; Tomas Gabrhelik; Jana Zapletalova

    Purpose  Extreme lateral interbody fusion (XLIF) is a method for stabilization of the lumbar spine. Intraoperatively, the surgeon identifies\\u000a the lumbar nerve roots with a stimulator to prevent their injury. The objective of this study was to determine the extent\\u000a to which shallow rocuronium-induced neuromuscular block must be intraoperatively reversed for reliable identification of nerve\\u000a roots.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  General anesthesia (midazolam–propofol–sufentanil–oxygen\\/air\\/sevoflurane–rocuronium) was administered

  10. Anterior Dislodgement of a Fusion Cage after Transforaminal Lumbar Interbody Fusion for the Treatment of Isthmic Spondylolisthesis

    PubMed Central

    Oh, Hyeong Seok; Lee, Sang-Ho

    2013-01-01

    Transforaminal lumbar interbody fusion (TLIF) is commonly used procedure for spinal fusion. However, there are no reports describing anterior cage dislodgement after surgery. This report is a rare case of anterior dislodgement of fusion cage after TLIF for the treatment of isthmic spondylolisthesis with lumbosacral transitional vertebra (LSTV). A 51-year-old man underwent TLIF at L4-5 with posterior instrumentation for the treatment of grade 1 isthmic spondylolisthesis with LSTV. At 7 weeks postoperatively, imaging studies demonstrated that banana-shaped cage migrated anteriorly and anterolisthesis recurred at the index level with pseudoarthrosis. The cage was removed and exchanged by new cage through anterior approach, and screws were replaced with larger size ones and cement augmentation was added. At postoperative 2 days of revision surgery, computed tomography (CT) showed fracture on lateral pedicle and body wall of L5 vertebra. He underwent surgery again for paraspinal decompression at L4-5 and extension of instrumentation to S1 vertebra. His back and leg pains improved significantly after final revision surgery and symptom relief was maintained during follow-up period. At 6 months follow-up, CT images showed solid fusion at L4-5 level. Careful cage selection for TLIF must be done for treatment of spondylolisthesis accompanied with deformed LSTV, especially when reduction will be attempted. Banana-shaped cage should be positioned anteriorly, but anterior dislodgement of cage and reduction failure may occur in case of a highly unstable spine. Revision surgery for the treatment of an anteriorly dislodged cage may be effectively performed using an anterior approach. PMID:24175028

  11. BMP-2-induced Neuroforaminal Bone Growth in the Setting of a Minimally Invasive Transforaminal Lumbar Interbody Fusion.

    PubMed

    Ahn, Junyoung; Tabaraee, Ehsan; Singh, Kern

    2015-06-01

    Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) has become a popular alternative to traditional methods of lumbar decompression and fusion. When compared with the open technique, the minimally invasive approach can result in decreased pain and blood loss as well as a shorter length of hospitalization. However, the narrower working channel through the tubular retractor increases the difficulty of decortication and bone grafting. Therefore, recombinant human bone morphogenetic proteins (rhBMP-2) is often utilized (although this is off-label) to create a more favorable interbody fusion environment. Recently, the use of rhBMP-2 has been associated with excessive bone growth in an MIS-TLIF. If this bone growth compresses the neighboring neural structures, patients may present with either new or recurrent radicular pain. Computed tomographic (CT) imaging can demonstrate heterotopic bone growth extending from the disk space into either the ipsilateral neuroforamen or lateral recess, which may result in the compression of the exiting or traversing root, respectively. The purpose of this article and the accompanying video is to demonstrate a technique for defining and resecting rhBMP-2-induced heterotopic bone growth following a previous MIS-TLIF. PMID:25978140

  12. Allogeneic morphogenetic protein vs. recombinant human bone morphogenetic protein-2 in lumbar interbody fusion procedures: a radiographic and economic analysis

    PubMed Central

    2013-01-01

    Background Since the introduction of rhBMP-2 (Infuse®) in 2002, surgeons have had an alternative substitute to autograft and its related donor site morbidity. Recently, the prevalence of reported adverse events and complications related to the use of rhBMP-2 has raised many ethical and legal concerns for surgeons. Additionally, the cost and decreasing reimbursement landscape of rhBMP-2 use have required identification of a viable alternative. Osteo allogeneic morphogenetic protein (OsteoAMP®) is a commercially available allograft-derived growth factor rich in osteoinductive, angiogenic, and mitogenic proteins. This study compares the radiographic fusion outcomes between rhBMP-2 and OsteoAMP allogeneic morphogenetic protein in lumbar interbody fusion spine procedures. Methods Three hundred twenty-one (321) patients from three centers underwent a transforaminal lumbar interbody fusion (TLIF) or lateral lumbar interbody fusion (LLIF) procedure and were assessed by an independent radiologist for fusion and radiographically evident complications. The independent radiologist was blinded to the intervention, product, and surgeon information. Two hundred and twenty-six (226) patients received OsteoAMP with autologous local bone, while ninety-five (95) patients received Infuse with autologous local bone. Patients underwent radiographs (x-ray and/or CT) at standard postoperative follow-up intervals of approximately 1, 3, 6, 12, and 18 months. Fusion was defined as radiographic evidence of bridging across endplates, or bridging from endplates to interspace disc plugs. Osteobiologic surgical supply costs were also analyzed to ascertain cost differences between OsteoAMP and rhBMP-2. Results OsteoAMP produced higher rates of fusion at 6, 12, and 18 months (p???0.01). The time required for OsteoAMP to achieve fusion was approximately 40% less than rhBMP-2 with approximately 70% fewer complications. Osteobiologic supply costs were 80.5% lower for OsteoAMP patients (73.7% lower per level) than for rhBMP-2. Conclusions Results of this study indicate that OsteoAMP is a viable alternative to rhBMP-2 both clinically and economically when used in TLIF and LLIF spine procedures. PMID:24373225

  13. Clinical Results of a Single Central Interbody Fusion Cage and Transpedicle Screws Fixation for Recurrent Herniated Lumbar Disc and Low-Grade Spondylolisthesis

    Microsoft Academic Search

    Kuo-Feng Huang; Tzu-Yung Chen

    Background: The posterior lumbar interbody fusion (PLIF) procedure allows restoration of the weight-bearing capacity to a more physiological ventral position and maintenance of disc space height. However, the procedure can be technically difficult and may cause complications. It has always been performed bilater- ally with paired cages; a single central cage has not been commonly used. Methods: Twenty-eight patients who

  14. Correction of Coronal Imbalance in Degenerative Lumbar Spine Disease Following Direct Lateral Interbody Fusion (DLIF)

    PubMed Central

    Kim, Ju Seong; Lee, Hyo Sang; Shin, Dong Ah; Yoon, Do Heum

    2012-01-01

    Objective The authors have recently been using a surgical technique of minimally invasive direct lateral interbody fusion (DLIF) for correcting of coronal imbalance. The purpose of this study was to evaluate the surgical outcome and complication of DLIF. Methods We undertook retrospective analysis of a consecutive series of 8 DLIF procedures in Degenerative lumbar spine disease since May 2011. Four patients underwent DLIF only, and the others underwent combined DLIF and posterior fixation. Data on intra- and postoperative complications were collected. The pre- and postoperative X-rays were reviewed. We investigated coronal deformity, Cobb's angle, and apical vertebral translation (AVT). The mean follow-up period was months with a range of 2 to 8 months. Results A mean preoperative coronal Cobb's angle was 21.8° (range 11.5-32.4°). Following after DLIF, the mean Cobb's angle was decreased to 13.0° (range 2.9-21.5°). Following additional posterior screw fixation, mean Cobb's angle was further decreased to 7.4° (range 2.9-13.2°). A mean preoperative AVT was 2.0 cm(range 0.6-3.5 cm), and improved to 1.4 cm(range 0.3-2.4 cm) and 0.8 cm(range 0.2-1.8 cm) postoperatively (DLIF and, posterior fixation respectively). One patient (12.5%) showed cage migration during follow-up period. Two patients (25%) developed motor weakness, and 4 patients (50%) experienced postoperative thigh paresthesias or dysesthesias. During follow up period, motor weakness had resolved in 1 patient. Sensory symptoms were improved in all patients at the last follow-up. Conclusion Degenerative lumbar disease can be effectively corrected by DLIF with acceptable complications. PMID:25983811

  15. Clinical and Radiological Outcomes of a New Cage for Direct Lateral Lumbar Interbody Fusion

    PubMed Central

    Kim, Shin Jae; Lee, Young Seok; Kim, Young Baeg; Hung, Vo Tan

    2014-01-01

    Objective In Korea, direct lateral interbody fusion (DLIF) was started since 2011, using standard cage (6° lordotic angle, 18mm width). Recently, a new wider cage with higher lordotic angle (12°, 22mm) was introduced. The aim of our study is to compare the clinical and radiologic outcomes of the two cage types. Methods We selected patients underwent DLIF, 125 cases used standard cages (standard group) and 38 cases used new cages (wide group). We followed them up for more than 6 months, and their radiological and clinical outcomes were analyzed retrospectively. For radiologic outcomes, lumbar lordotic angle (LLA), segmental lordoic angle (SLA), disc angle (DA), foraminal height change (FH), subsidence and intraoperative endplate destruction (iED) were checked. Clinical outcomes were compared using visual analog scale (VAS) score, Oswestry disability index (ODI) score and complications. Results LLA and SLA showed no significant changes postoperatively in both groups. DA showed significant increase after surgery in the wide group (p<0.05), but not in the standard group. Subsidence was significantly lower in the wide group (p<0.05). There was no difference in clinical outcomes between the two groups. Additional posterior decompression was done more frequently in the wide group. Postoperative change of foraminal height was significantly lower in the wide group (p<0.05). The iED was observed more frequently in the wide group (p<0.05) especially at the anterior edge of cage. Conclusion The new type of cage seems to result in more DA and less subsidence. But indirect foraminal decompression seems to be less effective than standard cage. Intraoperative endplate destruction occurs more frequently due to a steeper lordotic angle of the new cage. PMID:25346760

  16. Pelvic parameters of sagittal balance in extreme lateral interbody fusion for degenerative lumbar disc disease.

    PubMed

    Johnson, R D; Valore, A; Villaminar, A; Comisso, M; Balsano, M

    2013-04-01

    There is increasing interest in the use of pelvic indices to evaluate sagittal balance and predict outcomes in patients with spinal disease. Conventional posterior lumbar fusion techniques may adversely affect lumbar lordosis and spinal balance. Minimally invasive fusion of the lumbar spine is rapidly becoming a mainstay of treatment of lumbar degenerative disc disease. To our knowledge there are no studies evaluating the effect of extreme lateral interbody fusion (XLIF) on pelvic indices. Hence, our aim was to study the effect of XLIF on pelvic indices related to sagittal balance, and report the results of a prospective longitudinal clinical study and retrospective radiographic analyses of patients undergoing XLIF in a single centre between January 2009 and July 2011. Clinical outcomes are reported for 30 patients and the retrospective analyses of radiographic data is reported for 22 of these patients to assess global and segmental lumbar lordosis and pelvic indices. Effect of XLIF on the correction of scoliotic deformity was assessed in 15 patients in this series. A significant improvement was seen in the visual analogue scale score, the Oswestry Disability Index and the Short Form-36 at 2months and 6months (p<0.0001). The mean pelvic index was 48.6°±11.9° (± standard deviation, SD) with corresponding mean sacral slopes and pelvic tilt of 32.0°±10.6° (SD) and 18.0°±9.5 (SD), respectively. XLIF did not significantly affect sacral slope or pelvic tilt (p>0.2). Global lumbar lordosis was not affected by XLIF (p>0.4). XLIF significantly increased segmental lumbar lordosis by 3.3° (p<0.0001) and significantly decreased the scoliotic Cobb angle by 5.9° (p=0.01). We found that XLIF improved scoliosis and segmental lordosis and was associated with significant clinical improvement in patients with lumbar degenerative disc disease. However, XLIF did not change overall lumbar lordosis or significantly alter pelvic indices associated with sagittal balance. Long-term follow-up with a larger cohort will be required to further evaluate the effects of XLIF on sagittal balance. PMID:23375396

  17. En Bloc Partial Laminectomy and Posterior Lumbar Interbody Fusion in Foraminal Spinal Stenosis

    PubMed Central

    Kim, Hyung-Tae

    2009-01-01

    Study Design A retrospective study. Purpose An en bloc partial laminectomy and posterior lumbar interbody fusion (PLIF) in spinal stenosis patients with severe foraminal narrowing has a shorter operation time, less neural manipulation and allows indirect decompression by restoring the interforaminal height compared to other procedures. This study investigated the efficacy of the procedure. Overview of Literature PLIF is one of the most popular surgery for degenerative spine such as foraminal spinal stenosis, instability spondylolisthesis and discogenic pain. Various techniques for PLIF have their own advantages and disadvantages. But in some severe cases, we need an efficient method of PLIF for decompression and fusion. Methods This study examined 61 patients, who had 85 levels treated with PLIF using an en bloc partial laminectomy and facetectomy, and could be followed up for more than 2 years. The mean age of the patients and mean follow up period was 66 years and 39 months, respectively. The clinical results were evaluated using the MacNab's criteria, Visual Analogue Scale (VAS) score, and Korea Version Oswestry Disability Index (KODI). The union of the intervertebral space was evaluated using Lenke's criteria. The intervertebral angle and height of the posterior intervertebral disc were also measured. Results Excellent and good results were obtained in 54 cases (89%) according to MacNab's criteria. The VAS and KODI scores were 8.1 and 34.6, preoperatively, and 3.4, and 14.1, postoperatively. Bone union was A and B grades according to Lenke's criteria in 57 cases. The mean segmental angle and mean height of the posterior disc were respectively, 7.4° and 6.5 mm preoperatively, 9.1° and 10.6 mm postoperatively, and 8.0° and 9.7 mm in the last follow-up. There were 5 cases of postoperative infection, 4 cases of junctional problems and 1 case of screw malposition. Conclusions En bloc partial laminectomy and PLIF is an effective method for treating severe spinal stenosis with foraminal narrowing. PMID:20404950

  18. A comparison of perioperative charges and outcome between open and mini-open approaches for anterior lumbar discectomy and fusion.

    PubMed

    Smith, William D; Christian, Ginger; Serrano, Sherrie; Malone, Kyle T

    2012-05-01

    The objectives of this study were to examine charge data and long-term outcomes of two approaches for anterior lumbar interbody fusion: a mini-open lateral approach (extreme lateral interbody fusion, XLIF) and an open anterior approach (anterior lumbar interbody fusion, ALIF) through retrospective chart review. A total of 202 patients underwent surgery: 87 with ALIF (Open) and 115 with XLIF (Mini-open) procedures, all with transpedicular fixation. Complications occurred in 16.7% of Open, and 8.2% of Mini-open, procedures (p = 0.041). The mean charges ($US) for one-level Mini-open and Open procedures were $91,995 and $102,146, and for two-level procedures were $124,540 and $144,183, respectively. All differences were statistically significant (p < 0.05). This represents a 10% cost-savings, based on charges, for one-level and 13.6% for two-level Mini-open compared to Open procedures. Functional outcomes improved significantly at two years for both cohorts, although the difference between groups was not statistically significant. In conclusion, the Mini-open approach, compared to the Open, resulted in clinical as well as cost benefits with similar long-term outcomes. PMID:22236486

  19. Lateral Lumbar Interbody Fusion for the Correction of Spondylolisthesis and Adult Degenerative Scoliosis in High-Risk Patients: Early Radiographic Results and Complications

    PubMed Central

    Waddell, Brad; Briski, David; Qadir, Rabah; Godoy, Gustavo; Houston, Allison Howard; Rudman, Ernest; Zavatsky, Joseph

    2014-01-01

    Background Lateral lumbar interbody fusion (LLIF) is not associated with many of the complications seen in other interbody fusion techniques. This study used computed tomography (CT) scans, the radiographic gold standard, to assess interbody fusion rates achieved utilizing the LLIF technique in high-risk patients. Methods We performed a retrospective review of patients who underwent LLIF between January 2008 and July 2013. Forty-nine patients underwent nonstaged or staged LLIF on 119 levels with posterior correction and augmentation. Per protocol, patients received CT scans at their 1-year follow-up. Of the 49 patients, 21 patients with LLIF intervention on 54 levels met inclusion criteria. Two board-certified musculoskeletal radiologists and the senior surgeon (JZ) assessed fusion. Results Of the 21 patients, 6 patients had had previous lumbar surgery, and the cohort's comorbidities included osteoporosis, diabetes, obesity, and smoking, among others. Postoperative complications occurred in 12 (57.1%) patients and included anterior thigh pain and weakness in 6 patients, all of which resolved by 6 months. Two cases of proximal junctional kyphosis occurred, along with 1 case of hardware pullout. Two cases of abdominal atonia occurred. By CT scan assessment, each radiologist found fusion was achieved in 53 of 54 levels (98%). The radiologists' findings were in agreement with the senior surgeon. Conclusion Several studies have evaluated LLIF fusion and reported fusion rates between 88%-96%. Our results demonstrate high fusion rates using this technique, despite multiple comorbidities in the patient population. Spanning the ring apophysis with large LLIF cages along with supplemental posterior pedicle screw augmentation can enhance stability of the fusion segment and increase fusion rates. PMID:24688329

  20. TranS1 VEO system: a novel psoas-sparing device for transpsoas lumbar interbody fusion

    PubMed Central

    Hardenbrook, Mitchell A; Miller, Larry E; Block, Jon E

    2013-01-01

    Minimally invasive approaches for lumbar interbody fusion have been popularized in recent years. The retroperitoneal transpsoas approach to the lumbar spine is a technique that allows direct lateral access to the intervertebral disc space while mitigating the complications associated with traditional anterior or posterior approaches. However, a common complication of this procedure is iatrogenic injury to the psoas muscle and surrounding nerves, resulting in postsurgical motor and sensory deficits. The TranS1 VEO system (TranS1 Inc, Raleigh, NC, USA) utilizes a novel, minimally invasive transpsoas approach to the lumbar spine that allows direct visualization of the psoas and proximal nerves, potentially minimizing iatrogenic injury risk and resulting clinical morbidity. This paper describes the clinical uses, procedural details, and indications for use of the TranS1 VEO system. PMID:23766663

  1. Clinical and radiographic outcomes of extreme lateral approach to interbody fusion with ?-tricalcium phosphate and hydroxyapatite composite for lumbar degenerative conditions

    PubMed Central

    Rodgers, W. Blake; Gerber, Edward J.; Rodgers, Jody A.

    2012-01-01

    Background Historically, iliac crest bone graft has been used as the graft of choice for lumbar spine fusion procedures. Because fusion techniques have become less invasive, the demand for minimally disruptive grafting options has increased. This prospective study was performed to assess clinical and radiographic outcomes of patients treated with an iliac crest bone graft alternative and lateral lumbar interbody fusion. Methods Fifty degenerative lumbar patients were treated with the extreme lateral approach to interbody fusion and a ?-tricalcium phosphate–hydroxyapatite graft with bone marrow aspirate (BMA) at 1 or 2 adjacent levels. BMA was collected from the iliac crest with a bone aspiration needle and applied to the FormaGraft (NuVasive, Inc., San Diego, California) in a 1:1 ratio. Radiolucent cages were filled with FormaGraft strips, granules, or blocks and implanted in a standard fashion. Clinical data were collected at baseline, 6 weeks, and 3, 6, and 12 months and included visual analog scale, Oswestry Disability Index, and Short Form 36 patient-reported assessments. Fusion assessments were made from neutral anteroposterior/lateral radiographs, lateral flexion/extension radiographs, and computed tomography images taken at least 12 months after surgery. Results Forty-four patients treated at 49 levels completed follow-up. The mean patient age was 54.7 ± 10.8 years, and mean body mass index was 30.8 ± 7.7 kg/m2. Radiographic fusion was observed in 41 of 44 assessed levels (93.2%). Blood loss was less than 100 mL in 95.5% of patients. Of the patients, 93.2% spent 1 night or less in the hospital. By the 6-week follow-up, all clinical outcomes were significantly improved (P < .05). Improvements were maintained or increased throughout the course of follow-up. Conclusions This report shows that the technique of extreme lateral approach to interbody fusion in combination with FormaGraft and BMA in the interbody space is a safe and effective treatment option for interbody fusion of the lumbar spine when compared with other approaches and biologic options. PMID:25694867

  2. Technical note: Resolution of spontaneous electromyographic discharge following disk-space distraction during lateral transpsoas interbody fusion

    PubMed Central

    Woodall, Michael Neil; Shakir, Basheer; Smitherman, Adam; Choudhri, Haroon

    2013-01-01

    Purpose The lateral transpsoas interbody fusion (LTIF) is an increasingly popular minimally invasive technique for lumbar interbody fusion. Although a posterior approach to the lumbar spine has traditionally been favored for the treatment of canal stenosis and neural foraminal stenosis, a growing body of evidence suggests that indirect decompression of the spinal canal and neural foramen can be achieved using a lateral transpsoas approach to the lumbar spine. We present 2 cases that may suggest a role for spontaneous electromyography (s-EMG) monitoring in assessing the adequacy of decompression during LTIF. Methods The 2 cases presented in this technical note illustrate resolution of s-EMG firing during LTIF, following distraction across the disk space. Removal of the distracting device produced the return of s-EMG firing. Both of these cases were operated at the L2-3 level. Results In the first case, s-EMG firing was noted in the bilateral tibialis anterior leads. Resolution of EMG firing may suggest indirect decompression of the canal via ligamentotaxis as the L5 root traverses the L2-3 disk space. In the second case, s-EMG firing was noted in the left abductor hallucis and resolved with distraction of the L2-3 disk space. Again, this may be explained by canal decompression via ligamentotaxis as the S1 root traverses the L2-3 disk space. Conclusion In both cases, distraction across the disk space resulted in resolution of s-EMG discharges—this correlated with an improvement in symptoms. These findings may suggest a role for s-EMG as a marker for adequacy of decompression in a select subset of patients undergoing LTIF. Further study is needed to determine if resolution of s-EMG is a useful measure of indirect decompression during LTIF. PMID:25694902

  3. Minimally invasive trans-sacral approach to L5-S1 interbody fusion: Preliminary results from 1 center and review of the literature

    PubMed Central

    Bradley, W. Daniel; Hisey, Michael S.; Verma-Kurvari, Sunita; Ohnmeiss, Donna D.

    2012-01-01

    Background Lumbar interbody fusion has long been used for the treatment of painful degenerative spinal conditions. The anterior approach is not feasible in some patients, and the posterior approach is associated with a risk of neural complications and possibly muscle injury. A trans-sacral technique was developed that allows access to the L5-S1 disc space. The purposes of this study were to investigate the clinical outcome of trans-sacral interbody fusion in a consecutive series of patients from 1 center and to perform a comprehensive review of the literature on this procedure. Methods A literature search using PubMed was performed to identify articles published on trans-sacral axial lumbar interbody fusion (AxiaLIF). Articles reviewed included biomechanical testing, feasibility of the technique, and clinical results. The data from our center were collected retrospectively from charts for the consecutive series, beginning with the first case, of all patients undergoing fusion using the AxiaLIF technique. In most cases, posterior instrumentation was also used. A total of 41 patients with at least 6 months’ follow-up were included (mean follow-up, 22.2 months). The primary clinical outcome measures were visual analog scales separately assessing back and leg pain and the Oswestry Disability Index. Radiographic assessment of fusion was also performed. Results In the group of 28 patients undergoing single-level AxiaLIF combined with posterior fusion, the visual analog scale scores assessing back and leg pain and mean Oswestry Disability Index scores improved significantly (P < .01). In the remaining 13 patients, back pain improved significantly with a trend for improvement in leg pain. Reoperation occurred in 19.5% of patients; in half of these, reoperation was not related to the anterior procedure. Conclusions A review of the literature found that the AxiaLIF technique was similar to other fusion techniques with respect to biomechanical properties and produced acceptable clinical outcomes, although results varied among studies. Clinical relevance The AxiaLIF approach allows access to the L5-S1 interspace without violating the annulus or longitudinal ligaments and with minimal risk to dorsal neural elements. It may be a viable alternative to other approaches to interbody fusion at the L5-S1 level. It is important that the patients be selected carefully and surgeons are familiar with the presacral anatomy and the surgical approach. PMID:25694879

  4. Structural and mechanical evaluations of a topology optimized titanium interbody fusion cage fabricated by selective laser melting process.

    PubMed

    Lin, Chia-Ying; Wirtz, Tobias; LaMarca, Frank; Hollister, Scott J

    2007-11-01

    A topology optimized lumbar interbody fusion cage was made of Ti-Al6-V4 alloy by the rapid prototyping process of selective laser melting (SLM) to reproduce designed microstructure features. Radiographic characterizations and the mechanical properties were investigated to determine how the structural characteristics of the fabricated cage were reproduced from design characteristics using micro-computed tomography scanning. The mechanical modulus of the designed cage was also measured to compare with tantalum, a widely used porous metal. The designed microstructures can be clearly seen in the micrographs of the micro-CT and scanning electron microscopy examinations, showing the SLM process can reproduce intricate microscopic features from the original designs. No imaging artifacts from micro-CT were found. The average compressive modulus of the tested caged was 2.97+/-0.90 GPa, which is comparable with the reported porous tantalum modulus of 3 GPa and falls between that of cortical bone (15 GPa) and trabecular bone (0.1-0.5 GPa). The new porous Ti-6Al-4V optimal-structure cage fabricated by SLM process gave consistent mechanical properties without artifactual distortion in the imaging modalities and thus it can be a promising alternative as a porous implant for spine fusion. PMID:17415762

  5. Screw Placement Accuracy for Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery: A Study on 3-D Neuronavigation-Guided Surgery

    PubMed Central

    Torres, Jorge; James, Andrew R.; Alimi, Marjan; Tsiouris, Apostolos John; Geannette, Christian; Härtl, Roger

    2012-01-01

    Purpose?The aim of this study was to assess the impact of 3-D navigation for pedicle screw placement accuracy in minimally invasive transverse lumbar interbody fusion (MIS-TLIF). Methods?A retrospective review of 52 patients who had MIS-TLIF assisted with 3D navigation is presented. Clinical outcomes were assessed with the Oswestry Disability Index (ODI), Visual Analog Scales (VAS), and MacNab scores. Radiographic outcomes were assessed using X-rays and thin-slice computed tomography. Result?The mean age was 56.5 years, and 172 screws were implanted with 16 pedicle breaches (91.0% accuracy rate). Radiographic fusion rate at a mean follow-up of 15.6 months was 87.23%. No revision surgeries were required. The mean improvement in the VAS back pain, VAS leg pain, and ODI at 11.3 months follow-up was 4.3, 4.5, and 26.8 points, respectively. At last follow-up the mean postoperative disc height gain was 4.92?mm and the mean postoperative disc angle gain was 2.79 degrees. At L5–S1 level, there was a significant correlation between a greater disc space height gain and a lower VAS leg score. Conclusion?Our data support that application of 3-D navigation in MIS-TLIF is associated with a high level of accuracy in the pedicle screw placement. PMID:24353961

  6. Minimally invasive lateral transpsoas interbody fusion using a stand-alone construct for the treatment of adjacent segment disease of the lumbar spine: review of the literature and report of three cases.

    PubMed

    Palejwala, Sheri K; Sheen, Whitney A; Walter, Christina M; Dunn, Jack H; Baaj, Ali A

    2014-09-01

    We describe 3 patients who presented with radiographic signs and clinical symptoms of adjacent segment disease several years after undergoing L4-S1 posterior pedicle screw fusion. All patients underwent successful lateral lumbar interbody fusion (LLIF) at 1-2 levels above their previous constructs, using stand-alone cages, with complete resolution of radiculopathy and a significant improvement in low-back pain. In addition to a thorough analysis of these cases, we review the pertinent literature regarding treatment options for adjacent segment disease and the applications of the lateral lumbar interbody technique. PMID:25019458

  7. The Effect of the Retroperitoneal Transpsoas Minimally Invasive Lateral Interbody Fusion on Segmental and Regional Lumbar Lordosis

    PubMed Central

    Le, Tien V.; Vivas, Andrew C.; Dakwar, Elias; Baaj, Ali A.; Uribe, Juan S.

    2012-01-01

    Background. The minimally invasive lateral interbody fusion (MIS LIF) in the lumbar spine can correct coronal Cobb angles, but the effect on sagittal plane correction is unclear. Methods. A retrospective review of thirty-five patients with lumbar degenerative disease who underwent MIS LIF without supplemental posterior instrumentation was undertaken to study the radiographic effect on the restoration of segmental and regional lumbar lordosis using the Cobb angles on pre- and postoperative radiographs. Mean disc height changes were also measured. Results. The mean follow-up period was 13.3 months. Fifty total levels were fused with a mean of 1.42 levels fused per patient. Mean segmental Cobb angle increased from 11.10° to 13.61° (P < 0.001) or 22.6%. L2-3 had the greatest proportional increase in segmental lordosis. Mean regional Cobb angle increased from 52.47° to 53.45° (P = 0.392). Mean disc height increased from 6.50?mm to 10.04?mm (P < 0.001) or 54.5%. Conclusions. The MIS LIF improves segmental lordosis and disc height in the lumbar spine but not regional lumbar lordosis. Anterior longitudinal ligament sectioning and/or the addition of a more lordotic implant may be necessary in cases where significant increases in regional lumbar lordosis are desired. PMID:22919332

  8. Prospective Randomized Controlled Trial of The Stabilis Stand Alone Cage (SAC) Versus Bagby and Kuslich (BAK) Implants for Anterior Lumbar Interbody Fusion

    PubMed Central

    Lavelle, William; McLain, Robert F.; Rufo-Smith, Candace; Gurd, David P.

    2014-01-01

    Background Degenerative disc disease is common and debilitating for many patients. If conservative extensive care fails, anterior lumbar interbody fusion has proven to be an alternative form of surgical management. The Stabilis Stand Alone Cage(SAC) was introduced as a method to obtain stability and fusion. The purpose of this study was to determine whether the Stabilis Stand Alone Cage (SAC) is comparable in safety and efficacy to the Bagby and Kuslich (BAK) device. Methods As part of a prospective, randomized, controlled FDA trial, 73 patients underwent anterior interbody fusion using either the SAC(56%) or the BAK device (44%). Results Background characteristics were similar between the two groups. There was no significant difference between the SAC and BAK groups in mean operative time or mean blood loss during surgery. Adverse event rates did not differ between the groups. Assessment of plain radiographs could not confirm solid fusion in 63% of control and 71% of study patients. Functional scores from Owestry and SF-36 improved in both groups by the two-year follow-up. There were no significant differences between the SAC and BAK patients with respect to outcome. Conclusions Both the Stabilis Stand Alone Cage and the BAK Cage provided satisfactory improvement in function and pain relief, despite less than expected radiographic fusion rates. The apparent incongruency between fusion rates and functional outcomes suggests that either radiographs underestimate the true incidence of fusion, or that patients are obtaining good pain relief and improved function despite a lower rate of fusion than previously reported. This was a Level III study. PMID:25694930

  9. Initial Clinical Outcomes of Minimally Invasive Lateral Lumbar Interbody Fusion in Degenerative Lumbar Disease: A Preliminary Report on the Experience of a Single Institution with 30 Cases

    PubMed Central

    Na, Young Cheol; Lee, Hyo Sang; Shin, Dong Ah; Ha, Yoon; Yoon, Do Heum

    2012-01-01

    Objective The object of this study was to evaluate the clinical and radiological outcomes of minimally invasive lateral lumbar interbody fusion. Methods This study included 30 patients who underwent minimally invasive lateral lumbar interbody fusion at our hospital between May 2011 and February 2012 for the following diagnoses: degenerative disc disease, adjacent-segment degeneration, degenerative spondylolisthesis and lumbar degenerative scoliosis. Pain assessment was reported from 0 to 10 using a subjective visual analog scale (VAS) upon admission and at every follow-up day. Lumbar X-rays were obtained in the standing position upon admission and the 1st and 5th postoperative day, and at every follow-up day after the operation. The heights of the intervertebral disc space and neural foramen were measured using an electronic caliper with the PACS software. The surgical outcome was assessed as excellent, good, fair or poor using the Odom scale at the last follow-up. Results The mean VAS for low back pain were 4.93±1.47 on admission and 2.01±1.35 at last follow-up, respectively, and for leg pain, the scores were 4.87±2.16 on admission and 1.58±1.52 at last follow-up. The mean height of intervertebral disc space increased by 34% (7.93±2.33 preoperatively, and 11.09±4.33 immediately after surgery, p<0.01). The mean height of neural foramen also increased by 6.4% without any statistical significance (19.17±2.84 preoperatively, and 20.49±4.50 immediately after the surgery). Minimally invasive lateral lumbar interbody fusion was successful in 27 patients (90%) at last follow-up. Surgical complications were reported as transient postoperative thigh sensory changes (5 patients, 16.7%), transient psoas muscle weakness (3 patients, 10%), cage migration (2 patients, 6.7%), lumbar plexus injury (1 patient, 3.3%), and pain aggravation (1 patient, 3.3%). Conclusion The minimally invasive lateral lumbar interbody fusion is a safe and effective procedure for treating degenerative lumbar disease with good outcomes and moderate complications. Further follow-up is necessary to establish its safety and efficacy. PMID:25983813

  10. Short-Term Results of Transforaminal Lumbar Interbody Fusion Using Pedicle Screw with Cortical Bone Trajectory Compared with Conventional Trajectory

    PubMed Central

    Miyakoshi, Naohisa; Hongo, Michio; Ishikawa, Yoshinori; Kudo, Daisuke; Shimada, Yoichi

    2015-01-01

    Study Design Case-control study. Purpose To evaluate clinical and radiological results of transforaminal lumbar interbody fusion (TLIF) performed with cortical bone trajectory (CBT) pedicle screw insertion with those of TLIF using 'conventional' or percutaneous pedicle screw insertion. Overview of Literature CBT is a new trajectory for pedicle screw insertion in the lumbar spine; clinical and radiological results of TLIF using pedicle screws inserted with CBT are unclear. Methods In total, 26 patients (11 males, 15 females) were enrolled in this retrospective study and divided into three groups: TLIF with pedicle screw insertion by conventional minimally invasive methods via the Wiltse approach (M-TLIF, n=10), TLIF with percutaneous pedicle screw insertion (P-TLIF, n=6), and TLIF with pedicle screw insertion with CBT (CBT-TLIF, n=10). Surgical results and preand postoperative radiological findings were evaluated and compared. Results Intraoperative blood loss was significantly less with CBT-TLIF (p=0.03) than with M-TLIF. Postoperative lordotic angles did not differ significantly among the three groups. Complete fusions were obtained in 10 of 12 levels (83%) with M-TLIF, in seven levels (100%) with P-TLIF, and in 10 of 11 levels (91%) with CBT-TLIF. On postoperative computed tomography, correct positioning was seen in 84.1% of M-TLIF screws, 88.5% of P-TLIF screws, and 90% of CBT-TLIF screws. Conclusions CBT-TLIF resulted in less blood loss and a shorter operative duration than M-TLIF or P-TLIF. Postoperative rates of bone union, maintenance of lordotic angles, and accuracy of pedicle screw positions were similar among the three groups. PMID:26097661

  11. Biomechanical Analysis of a Newly Developed Shape Memory Alloy Hook in a Transforaminal Lumbar Interbody Fusion (TLIF) In Vitro Model

    PubMed Central

    Wang, Xi; Xu, Jing; Zhu, Yuexing; Li, Jiukun; Zhou, Si; Tian, Shunliang; Xiang, Yucheng; Liu, Xingmo; Zheng, Ying; Pan, Tao

    2014-01-01

    Objective The objective of this biomechanical study was to evaluate the stability provided by a newly developed shape memory alloy hook (SMAH) in a cadaveric transforaminal lumbar interbody fusion (TLIF) model. Methods Six human cadaveric spines (L1-S2) were tested in an in vitro flexibility experiment by applying pure moments of ±8 Nm in flexion/extension, left/right lateral bending, and left/right axial rotation. After intact testing, a TLIF was performed at L4-5. Each specimen was tested for the following constructs: unilateral SMAH (USMAH); bilateral SMAH (BSMAH); unilateral pedicle screws and rods (UPS); and bilateral pedicle screws and rods (BPS). The L3–L4, L4–L5, and L5-S1 range of motion (ROM) were recorded by a Motion Analysis System. Results Compared to the other constructs, the BPS provided the most stability. The UPS significantly reduced the ROM in extension/flexion and lateral bending; the BSMAH significantly reduced the ROM in extension/flexion, lateral bending, and axial rotation; and the USMAH significantly reduced the ROM in flexion and left lateral bending compared with the intact spine (p<0.05). The USMAH slightly reduced the ROM in extension, right lateral bending and axial rotation (p>0.05). Stability provided by the USMAH compared with the UPS was not significantly different. ROMs of adjacent segments increased in all fixed constructs (p>0.05). Conclusions Bilateral SMAH fixation can achieve immediate stability after L4–5 TLIF in vitro. Further studies are required to determine whether the SMAH can achieve fusion in vivo and alleviate adjacent segment degeneration. PMID:25474112

  12. A Systematic Review and Meta-Analysis of Unilateral versus Bilateral Pedicle Screw Fixation in Transforaminal Lumbar Interbody Fusion

    PubMed Central

    Hu, Xu-Qi; Wu, Xin-Lei; Xu, Cong; Zheng, Xu-Hao; Jin, Yong-Long; Wu, Li-Jun; Wang, Xiang-Yang; Xu, Hua-Zi; Tian, Nai-Feng

    2014-01-01

    Background Transforaminal lumbar interbody fusion (TLIF) has become one of the most widely used procedures for lumbar spinal disorders. However, it is still unclear whether TLIF with unilateral pedicle screw (PS) fixation is as effective as that with bilateral PS fixation. We performed a meta-analysis of the literatures and aimed to gain a better understanding of whether TLIF with unilateral PS fixation was safe and effective for lumbar diseases. Methodology/Principal Findings We systematically searched Ovid, Springer, and Medline databases for relevant randomized controlled trials (RCTs) that compared the clinical and radiological outcomes of unilateral versus bilateral PS fixation in TLIF. Risk of bias in included studies was assessed using the Cochrane Risk of Bias tool. We generated pooled risk ratios or weighted mean differences across studies. According to our predefined inclusion criteria, seven RCTs with a total of 441 patients were included in this study. Baseline characteristics were similar between the unilateral and bilateral groups. Our meta-analysis showed that no significant difference was detected between the two groups in terms of postoperative clinical function, fusion status, reoperation rate, complication rate, and hospital stay (p>0.05). Pooled estimates revealed that the unilateral group was associated with significantly reduced implant cost, operative time and blood loss (p<0.05). Conclusions/Significances Our meta-analysis suggested TLIF with unilateral PS fixation was as safe and effective as that with bilateral PS fixation for lumbar diseases in selected patients. Despite these findings, our meta-analysis was based on studies with small sample size and different study characteristics that might lead to the inconsistent results such as various functional outcomes among the included studies. Therefore, high-quality randomized controlled trials with larger sample size are also needed to further clarify these issues and to provide the long-term outcomes. PMID:24489929

  13. Transforaminal lumbar interbody fusion using unilateral pedicle screw fixation plus contralateral translaminar facet screw fixation in lumbar degenerative diseases

    PubMed Central

    Liu, Fubing; Jiang, Chun; Cao, Yuanwu; Jiang, Xiaoxing; Feng, Zhenzhou

    2014-01-01

    Background: Transforaminal lumbar interbody fusion (TLIF) has been used in lumbar degenerative diseases. Some researchers have applied unilateral fixation in TLIF to reduce operational trauma without compromising the clinical outcome, but it is always suspected biomechanically unstable. The supplementary contralateral translaminar facet screw (cTLFS) seemed to be able to overcome the inherent drawbacks of unilateral pedicle screw (uPS) fixation theoretically. This study evaluates the safety, feasibility and efficacy of TLIF using uPS with cTLFS fixation in the treatment of lumbar degenerative diseases (LDD). Materials and Methods: 50 patients (29 male) underwent the aforementioned surgical technique for their LDD between December 2009 and April 2012. The results were evaluated based on visual analogue scale (VAS) of the leg and back, Japanese Orthopedic Association (JOA) score and Oswestry Disability Index (ODI) were recorded. The radiographic examinations in form of X-ray, computed tomography (CT) or magnetic resonance imaging was done preoperatively and 1 week, 3 months, 6 months, 12 months and 24 months postoperatively. The student t-test was used for comparison between the preoperative values and postoperative counterparts. P < 0.05 was considered to be statistically significant. Results: Among 50 patients, 22 received one level fusion and 28 two level's, with corresponding operation time and estimated blood loss being approximately 90 min, 150 ml and 120 min, 200 ml, respectively. No severe complications happened perioperatively. The mean VAS (back, leg) scores dropped from (7.6, 7.5) preoperatively to (2.1, 0.6) at 12 months’ followup, ODI from 49.1 preoperatively to 5.6 and JOA score raised from 10.6 preoperatively to 28.5, all P < 0.001, suggesting of good clinical outcome. From the three-dimensional reconstructed CT, 62 out of 70 segments displayed solid fusion with fusion rate of 88.6% at 12 months postoperatively. Conclusions: TLIF using uPS fixation plus cTLFS fixation is a safe, feasible and effective technique in the treatment of one or two level lumbar degenerative diseases short termly. PMID:25143640

  14. Treatment of multilevel degenerative lumbar spinal stenosis with spondylolisthesis using a combination of microendoscopic discectomy and minimally invasive transforaminal lumbar interbody fusion

    PubMed Central

    WU, HAN; YU, WEI-DONG; JIANG, RUI; GAO, ZHONG-LI

    2013-01-01

    Degenerative lumbar spinal stenosis (DLSS) has become increasingly common and is characterized by multilevel disc herniation and lumbar spondylolisthesis, which are difficult to treat. The current study aimed to evaluate the short-term clinical outcomes and value of the combined use of microendoscopic discectomy (MED) and minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) for the treatment of multilevel DLSS with spondylolisthesis, and to compare the combination with traditional posterior lumbar interbody fusion (PLIF). A total of 26 patients with multilevel DLSS and spondylolisthesis underwent combined MED and MI-TLIF surgery using a single cage and pedicle rod-screw system. These cases were compared with 27 patients who underwent traditional PLIF surgery during the same period. Data concerning incision length, surgery time, blood loss, time of bed rest and Oswestry Disability Index (ODI) score prior to and following surgery were analyzed statistically. Statistical significance was reached in terms of incision length, blood loss and the time of bed rest following surgery (P<0.05), but there was no significant difference between the surgery time and ODI scores of the two groups. The combined use of MED and MI-TLIF has the advantages of reduced blood loss, less damage to the paraspinal soft tissue, shorter length of incision, shorter bed rest time, improved outcomes and shorter recovery times and has similar short-term clinical outcomes to traditional PLIF. PMID:23403827

  15. Surgeons' exposure to radiation in single- and multi-level minimally invasive transforaminal lumbar interbody fusion; a prospective study.

    PubMed

    Funao, Haruki; Ishii, Ken; Momoshima, Suketaka; Iwanami, Akio; Hosogane, Naobumi; Watanabe, Kota; Nakamura, Masaya; Toyama, Yoshiaki; Matsumoto, Morio

    2014-01-01

    Although minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) has widely been developed in patients with lumbar diseases, surgeons risk exposure to fluoroscopic radiation. However, to date, there is no studies quantifying the effective dose during MIS-TLIF procedure, and the radiation dose distribution is still unclear. In this study, the surgeons' radiation doses at 5 places on the bodies were measured and the effective doses were assessed during 31 consecutive 1- to 3-level MIS-TLIF surgeries. The operating surgeon, assisting surgeon, and radiological technologist wore thermoluminescent dosimeter on the unshielded thyroid, chest, genitals, right middle finger, and on the chest beneath a lead apron. The doses at the lens and the effective doses were also calculated. Mean fluoroscopy times were 38.7, 53.1, and 58.5 seconds for 1, 2, or 3 fusion levels, respectively. The operating surgeon's mean exposures at the lens, thyroid, chest, genitals, finger, and the chest beneath the shield, respectively, were 0.07, 0.07, 0.09, 0.14, 0.32, and 0.05 mSv in 1-level MIS-TLIF; 0.07, 0.08, 0.09, 0.18, 0.34, and 0.05 mSv in 2-level; 0.08, 0.09, 0.14, 0.15, 0.36, and 0.06 mSv in 3-level; and 0.07, 0.08, 0.10, 0.15, 0.33, and 0.05 mSv in all cases. Mean dose at the operating surgeon's right finger was significantly higher than other measurements parts (P<0.001). The operating surgeon's effective doses (0.06, 0.06, and 0.07 mSv for 1, 2, and 3 fusion levels) were low, and didn't differ significantly from those of the assisting surgeon or radiological technologist. Revision MIS-TLIF was not associated with higher surgeons' radiation doses compared to primary MIS-TLIF. There were significantly higher surgeons' radiation doses in over-weight than in normal-weight patients. The surgeons' radiation exposure during MIS-TLIF was within the safe level by the International Commission on Radiological Protection's guidelines. The accumulated radiation exposure, especially to surgeon's hands, should be carefully monitored. PMID:24736321

  16. Interbody Fusion Using VITOSS ® Bone Graft Substitute with Autogenous Bone Marrow Aspirate - One Year Interim Results

    Microsoft Academic Search

    Peter F. Ullrich

    Autologous cancellous bone is generally considered the gold standard for promoting spinal fusion. However, harvesting the autograft is associated with increased length of surgery and blood loss, as well as significant morbidity at the donor site and other complications. In addition, the availability of quality autologous graft may be limited. Synthetic calcium-based bone void fillers have been used successfully in

  17. The NEtherlands Cervical Kinematics (NECK) Trial. Cost-effectiveness of anterior cervical discectomy with or without interbody fusion and arthroplasty in the treatment of cervical disc herniation; a double-blind randomised multicenter study

    PubMed Central

    2010-01-01

    Background Patients with cervical radicular syndrome due to disc herniation refractory to conservative treatment are offered surgical treatment. Anterior cervical discectomy is the standard procedure, often in combination with interbody fusion. Accelerated adjacent disc degeneration is a known entity on the long term. Recently, cervical disc prostheses are developed to maintain motion and possibly reduce the incidence of adjacent disc degeneration. A comparative cost-effectiveness study focused on adjacent segment degeneration and functional outcome has not been performed yet. We present the design of the NECK trial, a randomised study on cost-effectiveness of anterior cervical discectomy with or without interbody fusion and arthroplasty in patients with cervical disc herniation. Methods/Design Patients (age 18-65 years) presenting with radicular signs due to single level cervical disc herniation lasting more than 8 weeks are included. Patients will be randomised into 3 groups: anterior discectomy only, anterior discectomy with interbody fusion, and anterior discectomy with disc prosthesis. The primary outcome measure is symptomatic adjacent disc degeneration at 2 and 5 years after surgery. Other outcome parameters will be the Neck Disability Index, perceived recovery, arm and neck pain, complications, re-operations, quality of life, job satisfaction, anxiety and depression assessment, medical consumption, absenteeism, and costs. The study is a randomised prospective multicenter trial, in which 3 surgical techniques are compared in a parallel group design. Patients and research nurses will be kept blinded of the allocated treatment for 2 years. The follow-up period is 5 years. Discussion Currently, anterior cervical discectomy with fusion is the golden standard in the surgical treatment of cervical disc herniation. Whether additional interbody fusion or disc prothesis is necessary and cost-effective will be determined by this trial. Trial Registration Netherlands Trial Register NTR1289 PMID:20553591

  18. Complications in patients undergoing combined transforaminal lumbar interbody fusion and posterior instrumentation with deformity correction for degenerative scoliosis and spinal stenosis

    PubMed Central

    Burneikiene, Sigita; Nelson, E. Lee; Mason, Alexander; Rajpal, Sharad; Serxner, Benjamin; Villavicencio, Alan T.

    2012-01-01

    Background: Utilization of the transforaminal lumbar interbody fusion (TLIF) approach for scoliosis offers the patients deformity correction and interbody fusion without the additional morbidity associated with more invasive reconstructive techniques. Published reports on complications associated with these surgical procedures are limited. The purpose of this study was to quantify the intra- and postoperative complications associated with the TLIF surgical approach in patients undergoing surgery for spinal stenosis and degenerative scoliosis correction. Methods: This study included patients undergoing TLIF for degenerative scoliosis with neurogenic claudication and painful lumbar degenerative disc disease. The TLIF technique was performed along with posterior pedicle screw instrumentation. The average follow-up time was 30 months (range, 15–47). Results: A total of 29 patients with an average age of 65.9 years (range, 49–83) were evaluated. TLIFs were performed at 2.2 levels on average (range, 1–4) in addition to 6.0 (range, 4–9) levels of posterolateral instrumented fusion. The preoperative mean lumbar lordosis was 37.6° (range, 16°–55°) compared to 40.5° (range, 26°–59.2°) postoperatively. The preoperative mean coronal Cobb angle was 32.3° (range, 15°–55°) compared to 15.4° (range, 1°–49°) postoperatively. The mean operative time was 528 min (range, 276–906), estimated blood loss was 1091.7 mL (range, 150–2500), and hospitalization time was 8.0 days (range, 3–28). A baseline mean Visual Analog Scale (VAS) score of 7.6 (range, 4–10) decreased to 3.6 (range, 0–8) postoperatively. There were a total of 14 (49%) hardware and/or surgical technique related complications, and 8 (28%) patients required additional surgeries. Five (17%) patients developed pseudoarthrosis. The systemic complications (31%) included death (1), cardiopulmonary arrest with resuscitation (1), myocardial infarction (1), pneumonia (5), and pulmonary embolism (1). Conclusion: This study suggests that although the TLIF approach is a feasible and effective method to treat degenerative adult scoliosis, it is associated with a high rate of intra- and postoperative complications and a long recovery process. PMID:22439116

  19. Surgical Data and Early Postoperative Outcomes after Minimally Invasive Lumbar Interbody Fusion: Results of a Prospective, Multicenter, Observational Data-Monitored Study

    PubMed Central

    Pereira, Paulo; Buzek, David; Franke, Jörg; Senker, Wolfgang; Kosmala, Arkadiusz; Hubbe, Ulrich; Manson, Neil; Rosenberg, Wout; Assietti, Roberto; Martens, Frederic; Barbanti Brodano, Giovanni; Scheufler, Kai-Michael

    2015-01-01

    Minimally invasive lumbar interbody fusion (MILIF) offers potential for reduced operative morbidity and earlier recovery compared with open procedures for patients with degenerative lumbar disorders (DLD). Firm conclusions about advantages of MILIF over open procedures cannot be made because of limited number of large studies of MILIF in a real-world setting. Clinical effectiveness of MILIF in a large, unselected real-world patient population was assessed in this Prospective, monitored, international, multicenter, observational study. Objective: To observe and document short-term recovery after minimally invasive interbody fusion for DLD. Materials and Methods: In a predefined 4-week analysis from this study, experienced surgeons (?30 MILIF surgeries pre-study) treated patients with DLD by one- or two-level MILIF. The primary study objective was to document patients’ short-term post-interventional recovery (primary objective) including back/leg pain (visual analog scale [VAS]), disability (Oswestry Disability Index [ODI]), health status (EQ-5D) and Patient satisfaction. Results: At 4 weeks, 249 of 252 patients were remaining in the study; the majority received one-level MILIF (83%) and TLIF was the preferred approach (94.8%). For one-level (and two-level) procedures, surgery duration was 128 (182) min, fluoroscopy time 115 (154) sec, and blood-loss 164 (233) mL. Time to first ambulation was 1.3 days and time to study-defined surgery recovery was 3.2 days. Patients reported significantly (P < 0.0001) reduced back pain (VAS: 2.9 vs 6.2), leg pain (VAS: 2.5 vs 5.9), and disability (ODI: 34.5% vs 45.5%), and a significantly (P < 0.0001) improved health status (EQ-5D index: 0.61 vs 0.34; EQ VAS: 65.4 vs 52.9) 4 weeks postoperatively. One adverse event was classified as related to the minimally invasive surgical approach. No deep site infections or deaths were reported. Conclusions: For experienced surgeons, MILIF for DLD demonstrated early benefits (short time to first ambulation, early recovery, high patient satisfaction and improved patient-reported outcomes) and low major perioperative morbidity at 4 weeks postoperatively. PMID:25811615

  20. Effects of Lordotic Angle of a Cage on Sagittal Alignment and Clinical Outcome in One Level Posterior Lumbar Interbody Fusion with Pedicle Screw Fixation

    PubMed Central

    Lee, Ji-Ho; Lee, Dong-Oh; Lee, Jae Hyup; Shim, Hee Jong

    2015-01-01

    This study aims to assess the differences in the radiological and clinical results depending on the lordotic angles of the cage in posterior lumbar interbody fusion (PLIF). We reviewed 185 segments which underwent PLIF using two different lordotic angles of 4° and 8° of a polyetheretherketone (PEEK) cage. The segmental lordosis and total lumbar lordosis of the 4° and 8° cage groups were compared preoperatively, as well as on the first postoperative day, 6th and 12th months postoperatively. Clinical assessment was performed using the ODI and the VAS of low back pain. The pre- and immediate postoperative segmental lordosis angles were 12.9° and 12.6° in the 4° group and 12° and 12.0° in the 8° group. Both groups exhibited no significant different segmental lordosis angle and total lumbar lordosis over period and time. However, the total lumbar lordosis significantly increased from six months postoperatively compared with the immediate postoperative day in the 8° group. The ODI and the VAS in both groups had no differences. Cages with different lordotic angles of 4° and 8° showed insignificant results clinically and radiologically in short-level PLIF surgery. Clinical improvements and sagittal alignment recovery were significantly observed in both groups. PMID:25685795

  1. Art Embodies ALife: The VIDA Competition

    Microsoft Academic Search

    Nell Tenhaaf

    2008-01-01

    Artificial Life artworks hold a unique place in the art world, one that has been largely mapped by the VIDA international competition through its annual recognition of outstanding works based on A-Life. Works that have received awards since the VIDA competition began in 1999 (25 prize-winning artworks and 56 honorary mentions) have gained viewer appreciation and popularity at the same

  2. A unique modular implant system enhances load sharing in anterior cervical interbody fusion: a finite element study

    PubMed Central

    2014-01-01

    Background The efficacy of dynamic anterior cervical plates is somewhat controversial. Screws in static-plate designs have a smaller diameter and can cut through bone under load. While not ideal, this unintended loosening can help mitigate stress shielding. Stand-alone interbody devices with integral fixation have large endplate contact areas that may inhibit or prevent loosening of the fixation. This study investigates the load sharing ability of a novel dynamic plate design in preventing the stress shielding of the graft material compared to the non-dynamic devices. Methods An experimentally validated intact C5-C6 finite element model was modified to simulate discectomy and accommodate implant-graft assembly. Four implant iterations were modeled; InterPlate titanium device with dynamic surface features (springs), InterPlate titanium non-dynamic device, InterPlate titanium design having a fully enclosed graft chamber, and the InterPlate design in unfilled PEEK having a fully enclosed graft chamber. All the models were fixed at the inferior-most surface of C6 and the axial displacement required to completely embed the dynamic surface features was applied to the model. Results InterPlate device with dynamic surface features induced higher graft stresses compared to the other design iterations resulting in uniform load sharing. The distribution of these graft stresses were more uniform for the InterPlate dynamic design. Conclusions These results indicate that the dynamic design decreases the stress shielding by increasing and more uniformly distributing the graft stress. Fully enclosed graft chambers increase stress shielding. Lower implant material modulus of elasticity does not reduce stress shielding significantly. PMID:24618205

  3. K-Wire fracture during minimally invasive transforaminal lumbar interbody fusion: Report of six cases and recommendations for avoidance and management

    PubMed Central

    Scheer, Justin K.; Harvey, Michael J.; Dahdaleh, Nader S.; Smith, Zachary A.; Fessler, Richard G.

    2014-01-01

    Background: Although rare, minimally invasive spine techniques do have the risk of intraoperative device failure. Kirschner wire (K-wire) fractures during minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) have not been previously reported. This report focuses on the incidence of k-wire fractures following MI-TLIF and describes techniques to help avoid and treat these fractures when they occur. Methods: Inclusion criteria: (i) patients underwent 1, 2, or 3 level MI-TLIF over a 10-year period and (ii) had a k-wire fracture leading to a retained fragment. Exclusion criteria included: >10° coronal curves, significant sagittal malalignment, infection, and preoperative instrumentation failure. Results: Of 513 patients undergoing MI-TLIF, 6 (1.2%) sustained k-wire fracture (3 males, 3 females, mean age 43 ± 13 years). Complications included k-wire fracture alone (4 patients), cerebrospinal fluid (CSF) leak (1 patient), and both ileus and revision for hardware removal (1 patient). All six patients went home postoperatively. The mean follow-up duration was 27.7 ± 37.4 months. All retained k-wire fragments were located in the vertebral bodies at the tip of the pedicle screws; none breached the anterior cortex of the vertebral bodies. None of the k-wires migrated at final follow-up 7.8 years (93.7 months) postoperatively. Furthermore, no complications were attributed to retained k-wires. Conclusions: K-wire fractures during MI-TLIF are rare (incidence of 1.2%) and retained k-wire segments led to no postoperative complications (e.g. no migration). PMID:25593770

  4. The Significance of Removing Ruptured Intervertebral Discs for Interbody Fusion in Treating Thoracic or Lumbar Type B and C Spinal Injuries through a One-Stage Posterior Approach

    PubMed Central

    Zhang, Qian-Shi; Lü, Guo-Hua; Wang, Xiao-Bin; Li, Jing

    2014-01-01

    Objectives To identify the negative effect on treatment results of reserving damaged intervertebral discs when treating type B and type C spinal fracture-dislocations through a one-stage posterior approach. Methods This is a retrospective review of 53 consecutive patients who were treated in our spine surgery center from January 2005 to May 2012 due to severe thoracolumbar spinal fracture-dislocation. The patients in Group A (24 patients) underwent long-segment instrumentation laminectomy with pedicle screw-rod fixators for neural decompression. In Group B (29 patients), the patients underwent long-segment instrumentation laminectomy with pedicle screw-rod fixators for neural decompression evacuating of the ruptured disc and inserting of a bone graft into the evacuated disc space for interbody fusion. The mean time between injury and operation was 4.1 days (range 2–15 days). The clinical, radiologic and complication outcomes were analyzed retrospectively. Results Periodic follow-ups were carried out until an affirmative union or treatment failure took place. A progressive kyphosis angle larger than 10°, loss of disc height, pseudoarthrosis, recurrence of dislocation or subluxation, or instrument failure before fusion were considered treatment failures. Treatment failures were detected in 13 cases in Group A (failure rate was 54.2%). In Group B, there were 28 cases in which definitive bone fusion was demonstrated on CT scans, and CT scans of the other cases demonstrated undefined pseudoarthrosis without hardware failure. There were statistically significant differences between the two groups (p<0.001 chi-square test). The neurologic recoveries, assessed by the ASIA scoring system, were not satisfactory for the neural deficit patients in either group, indicating there was no significant difference with regard to neurologic recovery between the two groups (p>0.05 Fisher's exact test). Conclusion Intervertebral disc damage is a common characteristic in type B and C spinal fracture-dislocation injuries. The damaged intervertebral disc should be removed and substituted with a bone graft because reserving the damaged disc in situ increases the risk of treatment failure. PMID:24827733

  5. The CASCADE trial: effectiveness of ceramic versus PEEK cages for anterior cervical discectomy with interbody fusion; protocol of a blinded randomized controlled trial

    PubMed Central

    2013-01-01

    Background Anterior cervical discectomy with interbody fusion cages is considered the standard surgical procedure in patients with cervical disc herniation. However, PEEK or metal cages have some undesirable imaging characteristics, leading to a search for alternative materials not creating artifacts on images; silicon nitride ceramic. Whether patients treated with silicon nitride ceramic cages have similar functional outcome as patients treated with PEEK cages is not known. We present the design of the CASCADE trial on effectiveness of ceramic cages versus PEEK cages in patients with cervical disc herniation and/or osteophytes. Methods/Design Patients (age 18–75 years) with monoradicular symptoms in one or both arms lasting more than 8 weeks, due to disc herniation and/or osteophytes, are eligible for the trial. The study is designed as a randomized controlled equivalence trial in which patients are blinded to the type of cage for 1 year. The total follow-up period is 2 years. The primary outcome measure is improvement in the Neck and Disability Index (NDI). Secondary outcomes measures include improvement in arm pain and neck pain (VAS), SF-36 and patients' perceived recovery. The final elements of comparison are perioperative statistics including operating time, blood loss, length of hospital stay, and adverse events. Lateral plane films at each follow-up visit and CT scan (at 6 months) will be used to judge fusion and the incidence of subsidence. Based on a power of 90% and assuming 8% loss to follow-up, 100 patients will be randomized into the 2 groups. The first analysis will be conducted when all patients have 1 year of follow-up, and the groups will be followed for 1 additional year to judge stability of outcomes. Discussion While the new ceramic cage has received the CE Mark based on standard compliance and animal studies, a randomized comparative study with the golden standard product will provide more conclusive information for clinicians. Implementation of any new device should only be done after completion of randomized controlled effectiveness trials. PMID:23947902

  6. Static and dynamic fatigue behavior of topology designed and conventional 3D printed bioresorbable PCL cervical interbody fusion devices.

    PubMed

    Knutsen, Ashleen R; Borkowski, Sean L; Ebramzadeh, Edward; Flanagan, Colleen L; Hollister, Scott J; Sangiorgio, Sophia N

    2015-09-01

    Recently, as an alternative to metal spinal fusion cages, 3D printed bioresorbable materials have been explored; however, the static and fatigue properties of these novel cages are not well known. Unfortunately, current ASTM testing standards used to determine these properties were designed prior to the advent of bioresorbable materials for cages. Therefore, the applicability of these standards for bioresorbable materials is unknown. In this study, an image-based topology and a conventional 3D printed bioresorbable poly(?)-caprolactone (PCL) cervical cage design were tested in compression, compression-shear, and torsion, to establish their static and fatigue properties. Difficulties were in fact identified in establishing failure criteria and in particular determining compressive failure load. Given these limitations, under static loads, both designs withstood loads of over 650N in compression, 395N in compression-shear, and 0.25Nm in torsion, prior to yielding. Under dynamic testing, both designs withstood 5 million (5M) cycles of compression at 125% of their respective yield forces. Geometry significantly affected both the static and fatigue properties of the cages. The measured compressive yield loads fall within the reported physiological ranges; consequently, these PCL bioresorbable cages would likely require supplemental fixation. Most importantly, supplemental testing methods may be necessary beyond the current ASTM standards, to provide more accurate and reliable results, ultimately improving preclinical evaluation of these devices. PMID:26072198

  7. Biomechanics of Lateral Interbody Spacers: Going Wider for Going Stiffer

    PubMed Central

    Pimenta, Luiz; Turner, Alexander W. L.; Dooley, Zachary A.; Parikh, Rachit D.; Peterson, Mark D.

    2012-01-01

    This study investigates the biomechanical stability of a large interbody spacer inserted by a lateral approach and compares the biomechanical differences with the more conventional transforaminal interbody fusion (TLIF), with and without supplemental pedicle screw (PS) fixation. Twenty-four L2-L3 functional spinal units (FSUs) were tested with three interbody cage options: (i) 18?mm XLIF cage, (ii) 26?mm XLIF cage, and (iii) 11?mm TLIF cage. Each spacer was tested without supplemental fixation, and with unilateral and bilateral PS fixation. Specimens were subjected to multidirectional nondestructive flexibility tests to 7.5?N·m. The range of motion (ROM) differences were first examined within the same group (per cage) using repeated-measures ANOVA, and then compared between cage groups. The 26?mm XLIF cage provided greater stability than the 18?mm XLIF cage with unilateral PS and 11?mm TLIF cage with bilateral PS. The 18?mm XLIF cage with unilateral PS provided greater stability than the 11?mm TLIF cage with bilateral PS. This study suggests that wider lateral spacers are biomechanically stable and offer the option to be used with less or even no supplemental fixation for interbody lumbar fusion. PMID:23213284

  8. Biomechanics of lateral interbody spacers: going wider for going stiffer.

    PubMed

    Pimenta, Luiz; Turner, Alexander W L; Dooley, Zachary A; Parikh, Rachit D; Peterson, Mark D

    2012-01-01

    This study investigates the biomechanical stability of a large interbody spacer inserted by a lateral approach and compares the biomechanical differences with the more conventional transforaminal interbody fusion (TLIF), with and without supplemental pedicle screw (PS) fixation. Twenty-four L2-L3 functional spinal units (FSUs) were tested with three interbody cage options: (i) 18?mm XLIF cage, (ii) 26?mm XLIF cage, and (iii) 11?mm TLIF cage. Each spacer was tested without supplemental fixation, and with unilateral and bilateral PS fixation. Specimens were subjected to multidirectional nondestructive flexibility tests to 7.5?N·m. The range of motion (ROM) differences were first examined within the same group (per cage) using repeated-measures ANOVA, and then compared between cage groups. The 26?mm XLIF cage provided greater stability than the 18?mm XLIF cage with unilateral PS and 11?mm TLIF cage with bilateral PS. The 18?mm XLIF cage with unilateral PS provided greater stability than the 11?mm TLIF cage with bilateral PS. This study suggests that wider lateral spacers are biomechanically stable and offer the option to be used with less or even no supplemental fixation for interbody lumbar fusion. PMID:23213284

  9. Extreme Lateral Interbody Fusion Procedure

    MedlinePLUS Videos and Cool Tools

    ... perform this operation. Of course, everything requires a learning curve. This is something that is done many ... cameras don't have -- we cannot get them deep enough to look at the disc space, but ...

  10. Compressive strength of interbody cages in the lumbar spine: the effect of cage shape, posterior instrumentation and bone density

    Microsoft Academic Search

    B. Jost; P. A. Cripton; T. Lund; T. R. Oxland; K. Lippuner; P. Jaeger; L.-P. Nolte

    1998-01-01

    One goal of interbody fusion is to increase the height of the degenerated disc space. Interbody cages in particular have\\u000a been promoted with the claim that they can maintain the disc space better than other methods. There are many factors that\\u000a can affect the disc height maintenance, including graft or cage design, the quality of the surrounding bone and the

  11. Extent of intraoperative muscle dissection does not affect long-term outcomes after minimally invasive surgery versus open-transforaminal lumbar interbody fusion surgery: A prospective longitudinal cohort study

    PubMed Central

    Adogwa, Owoicho; Johnson, Kwame; Min, Elliot T.; Issar, Neil; Carr, Kevin R.; Huang, Kevin; Cheng, Joseph

    2012-01-01

    Background: Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) versus open TLIF, addressing lumbar degenerative disc disease (DDD) or grade I spondylolisthesis (DS), are associated with shorter hospital stays, decreased blood loss, quicker return to work, and equivalent short- and long-term outcomes. However, no prospective study has assessed whether the extent of intraoperative muscle trauma utilizing creatinine phosphokinase levels (CPK) differently impacts long-term outcomes. Methods: Twenty-one patients underwent MIS-TLIF (n = 14) versus open-TLIF (n = 7) for DDD or DS. Serum CPK levels were measured at baseline, and postoperatively (days 1, 7, and 1.5, 3 and 6 months). The correlation between the extent of intraoperative muscle trauma and two-year improvement in functional disability was evaluated (multivariate regression analysis). Additionally, baseline and two-year changes in Visual Analog Scale (VAS)-leg pain (LP), VAS-back pain (BP), Oswestry Disability Index (ODI), Short-Form-36 (SF-36) Physical Component Score (PCS) and SF-36 Mental Component Score (MCS), and postoperative satisfaction with surgical care were assessed. Results: Although the mean change from baseline in the serum creatine phosphokinase level on POD 1 was greater for MIS-TLIF (628.07) versus open-TLF (291.42), this did not correlate with lesser two-year improvement in functional disability. Both cohorts also showed similar two-year improvement in VAS-LP, ODI, and SF-36 PCS/MCS. Conclusion: Increased intraoperative muscle trauma unexpectedly observed in higher postoperative CPK levels for MIS-TLIF versus open-TLIF did not correlate with any differences in two-year improvement in pain and functional disability. PMID:23248754

  12. Development of a 4-axis load cell used for lumbar interbody load measurements.

    PubMed

    Demetropoulos, Constantine K; Morgan, Craig R; Sengupta, Dilip K; Herkowitz, Harry N

    2009-09-01

    Numerous studies have assessed lumbar interbody fusion, but little data from direct interbody load measurements exists. This manuscript describes an interbody fusion cage with integrated 4-axis load cell that can simulate implant heights of 13, 15, 17, 19 and 21 mm. The calibrated load cell was accurate to within 7.9% for point compressive loads over the central 8 mm x 8 mm region, but up to 26.8% for eccentric loads on the outer 16 mm x 16 mm rim of the device (although typically errors were less than half). Anterior-posterior shear and lateral shear loads did not affect compressive load measurement (<1.0% and <3.5%, respectively). Moments calculated from 4 load sensing corner pillars demonstrated errors below 2.3% in lateral bending and 2.1% in flexion-extension. Although this device does not have the accuracy of other much larger corpectomy implants, it incorporates four channels of load and simulates multiple implant heights, making for a favorable comparison in this restricted space. This device has immediate use in cadaveric testing, providing data previously not attainable, and serves as a novel technological step towards an implantable interbody device with multi-axis load sensing capability. As per the authors' knowledge, no such device has previously been described. PMID:19447666

  13. Spine interbody implants: material selection and modification, functionalization and bioactivation of surfaces to improve osseointegration.

    PubMed

    Rao, Prashanth J; Pelletier, Matthew H; Walsh, William R; Mobbs, Ralph J

    2014-05-01

    The clinical outcome of lumbar spinal fusion is correlated with achievement of bony fusion. Improving interbody implant bone on-growth and in-growth may enhance fusion, limiting pseudoarthrosis, stress shielding, subsidence and implant failure. Polyetheretherketone (PEEK) and titanium (Ti) are commonly selected for interbody spacer construction. Although these materials have desirable biocompatibility and mechanical properties, they require further modification to support osseointegration. Reports of extensive research on this topic are available in biomaterial-centric published reports; however, there are few clinical studies concerning surface modification of interbody spinal implants. The current article focuses on surface modifications aimed at fostering osseointegration from a clinician's point of view. Surface modification of Ti by creating rougher surfaces, modifying its surface topography (macro and nano), physical and chemical treatment and creating a porous material with high interconnectivity can improve its osseointegrative potential and bioactivity. Coating the surface with osteoconductive materials like hydroxyapatite (HA) can improve osseointegration. Because PEEK spacers are relatively inert, creating a composite by adding Ti or osteoconductive materials like HA can improve osseointegration. In addition, PEEK may be coated with Ti, effectively bio-activating the coating. PMID:24890288

  14. Lateral Transpsoas Fusion: Indications and Outcomes

    PubMed Central

    Patel, Vishal C.; Park, Daniel K.; Herkowitz, Harry N.

    2012-01-01

    Spinal fusion historically has been used extensively, and, recently, the lateral transpsoas approach to the thoracic and lumbar spine has become an increasingly common method to achieve fusion. Recent literature on this approach has elucidated its advantage over more traditional anterior and posterior approaches, which include a smaller tissue dissection, potentially lower blood loss, no need for an access surgeon, and a shorter hospital stay. Indications for the procedure have now expanded to include degenerative disc disease, spinal stenosis, degenerative scoliosis, nonunion, trauma, infection, and low-grade spondylolisthesis. Lateral interbody fusion has a similar if not lower rate of complications compared to traditional anterior and posterior approaches to interbody fusion. However, lateral interbody fusion has unique complications that include transient neurologic symptoms, motor deficits, and neural injuries that range from 1 to 60% in the literature. Additional studies are required to further evaluate and monitor the short- and long-term safety, efficacy, outcomes, and complications of lateral transpsoas procedures. PMID:23213303

  15. Dissection of left iliac artery during anterior lumbar interspace fusion: Report of a case.

    PubMed

    Fischer, Uwe M; Davies, Mark G; Sayed, Hosam El

    2015-04-01

    Vascular injury is an uncommon complication of spine surgery. Among the different approaches, anterior lumbar interbody fusion has increased potential for vascular injuries, since the great vessels and their branches overly the disc spaces to be operated on, and retraction of these vessels is necessary to gain adequate surgical exposure. The reported incidence for anterior lumbar interbody fusion-associated vascular injuries ranges from 0% to 18.1%, with venous laceration as the most common type. We report a case of anterior lumbar interbody fusion-associated left common iliac artery dissection leading to delayed acute limb ischemia developing in early post-operative period. PMID:24848500

  16. Biomechanical stability of a bioabsorbable self-retaining polylactic acid/nano-sized ?-tricalcium phosphate cervical spine interbody fusion device in single-level anterior cervical discectomy and fusion sheep models

    PubMed Central

    Cao, Lu; Duan, Ping-Guo; Li, Xi-Lei; Yuan, Feng-Lai; Zhao, Ming-Dong; Che, Wu; Wang, Hui-Ren; Dong, Jian

    2012-01-01

    Purpose The aim of this study was to investigate the biomechanical stability provided by a novel, polylactic acid/nano-sized, ?-tricalcium phosphate, bioabsorbable, self-retaining cervical fusion cage (BCFC). Methods Quasistatic nonconstraining torques (maximum 1.5 NM) induced flexion, extension, lateral bending (±1.5 NM), and axial rotation (±1.5 NM) on 32 sheep cervical spines (C2–C5). The motion segment C3–C4 was first tested intact; the following groups were tested after complete discectomy: autologous tricortical iliac crest bone graft, Medtronic–Wego polyetheretherketone (PEEK) cage, Solis PEEK cage, and BCFC. The autologous bone graft group was tested with an anterior plate. The mean range of motion (ROM) was calculated from the load-displacement curves. Results BCFC significantly decreased ROM in lateral bending and axial rotation compared to other implants, and no significant difference in ROM between two types of PEEK cages and BCFC could be observed in flexion and extension. Anterior cervical plate (ACP) significantly decreased ROM in flexion and extension, but no significant difference in ROM between BCFC and bone graft plus ACP could be determined in lateral bending and axial rotation. Conclusion The BCFC device showed better stability to autologous tricortical iliac crest bone graft and PEEK cages in single-level anterior cervical discectomy and fusion models and thus may be a potential alternative to the current PEEK cages. PMID:23226018

  17. A-life, Organism and Body: the semiotics of emergent levels Claus Emmeche1

    E-print Network

    Emmeche, Claus

    117 A-life, Organism and Body: the semiotics of emergent levels Claus Emmeche1 1 Center This paper comments upon some of the open problems in ar- tificial life (cf. Bedeau et al 2000) from the emerging field of biosemio- tics, the study of life processes as sign processes. Semiotics, in the sense

  18. An Ecology of Text: Using Text Retrieval to Study Alife on the Net

    Microsoft Academic Search

    Michael L Best

    1998-01-01

    I introduce a new alife model, an ecology based on a corpus of text, and apply it to the analysis of posts to USENET News. In this corporal ecology posts are organisms, the newsgroups of NetNews define an environment, and human posters situated in their wider context make up a scarce resource. I apply latent semantic indexing (LSI), a text

  19. An Ecology of Text: Using Text Retrieval to Study Alife on the Net

    Microsoft Academic Search

    Michael L. Best

    1997-01-01

    I introduce a new alife model, an ecology based on a corpus of text, and apply it to the analysis of posts to USENET News. In this corporal ecology posts are organisms, the newsgroups of NetNews define an environment, and human posters situated in their wider context make up a scarce resource. I apply latent semantic indexing (LSI), a text

  20. Implementation Brief: Medical i2b2 NLP Smoking Challenge: The ALife System Architecture and Methodology

    Microsoft Academic Search

    Daniel T. Heinze; Mark L. Morsch; Brian C. Potter; Ronald E. Sheffer Jr.

    2008-01-01

    We describe the architecture of LifeCode® (A-Life Medical, Inc.), a natural language processing system for free-text clinical information extraction, our methodology in applying LifeCode® to the i2b2 smoking challenge, and statistical measures for performance evaluation. Due to the limited test size and the coefficient of variation in the test standard, it is difficult to draw conclusions regarding the relative efficacy

  1. Construct Rigidity after Fatigue Loading in Pedicle Subtraction Osteotomy with or without Adjacent Interbody Structural Cages.

    PubMed

    Deviren, Vedat; Tang, Jessica A; Scheer, Justin K; Buckley, Jenni M; Pekmezci, Murat; McClellan, R Trigg; Ames, Christopher P

    2012-12-01

    Introduction?Studies document rod fracture in pedicle subtraction osteotomy (PSO) settings where disk spaces were preserved above or adjacent to the PSO. This study compares the multidirectional bending rigidity and fatigue life of PSO segments with or without interbody support. Methods?Twelve specimens received bilateral T12-S1 posterior fixation and L3 PSO. Six received extreme lateral interbody fusion (XLIF) cages in addition to PSO at L2-L3 and L3-L4; six had PSO only. Flexion-extension, lateral bending, and axial rotation (AR) tests were conducted up to 7.5 Newton-meters (Nm) for groups: (1) posterior fixation, (2) L3 PSO, (3) addition of cages (six specimens). Relative motion across the osteotomy (L2-L4) and entire fixation site (T12-S1) was measured. All specimens were then fatigue tested for 35K cycles. Results?Regardingmultiaxial bending, there was a significant 25.7% reduction in AR range of motion across L2-L4 following addition of cages. Regarding fatigue bending, dynamic stiffness, though not significant (p?=?0.095), was 22.2% greater in the PSO?+?XLIF group than in the PSO-only group. Conclusions?Results suggest that placement of interbody cages in PSO settings has a potential stabilizing effect, which is modestly evident in the acute setting. Inserting cages in a second-stage surgery remains a viable option and may benefit patients in terms of recovery but additional clinical studies are necessary to confirm this. PMID:24353970

  2. Construct Rigidity after Fatigue Loading in Pedicle Subtraction Osteotomy with or without Adjacent Interbody Structural Cages

    PubMed Central

    Deviren, Vedat; Tang, Jessica A.; Scheer, Justin K.; Buckley, Jenni M.; Pekmezci, Murat; McClellan, R. Trigg; Ames, Christopher P.

    2012-01-01

    Introduction?Studies document rod fracture in pedicle subtraction osteotomy (PSO) settings where disk spaces were preserved above or adjacent to the PSO. This study compares the multidirectional bending rigidity and fatigue life of PSO segments with or without interbody support. Methods?Twelve specimens received bilateral T12–S1 posterior fixation and L3 PSO. Six received extreme lateral interbody fusion (XLIF) cages in addition to PSO at L2–L3 and L3–L4; six had PSO only. Flexion-extension, lateral bending, and axial rotation (AR) tests were conducted up to 7.5 Newton-meters (Nm) for groups: (1) posterior fixation, (2) L3 PSO, (3) addition of cages (six specimens). Relative motion across the osteotomy (L2–L4) and entire fixation site (T12–S1) was measured. All specimens were then fatigue tested for 35K cycles. Results?Regardingmultiaxial bending, there was a significant 25.7% reduction in AR range of motion across L2–L4 following addition of cages. Regarding fatigue bending, dynamic stiffness, though not significant (p?=?0.095), was 22.2% greater in the PSO?+?XLIF group than in the PSO-only group. Conclusions?Results suggest that placement of interbody cages in PSO settings has a potential stabilizing effect, which is modestly evident in the acute setting. Inserting cages in a second-stage surgery remains a viable option and may benefit patients in terms of recovery but additional clinical studies are necessary to confirm this. PMID:24353970

  3. Expandable Polyaryl-Ether-Ether-Ketone Spacers for Interbody Distraction in the Lumbar Spine

    PubMed Central

    Alimi, Marjan; Shin, Benjamin; Macielak, Michael; Hofstetter, Christoph P.; Njoku, Innocent; Tsiouris, Apostolos J.; Elowitz, Eric; Härtl, Roger

    2015-01-01

    Study Design?Retrospective case series. Objective?StaXx XD (Spine Wave, Inc., Shelton, CT, United States) is an expandable polyaryl-ether-ether-ketone (PEEK) wafer implant utilized in the treatment of lumbar degenerative disease. PEEK implants have been successfully used as interbody devices. Few studies have focused on expandable PEEK devices. The aim of the current study is to determine the radiographic and clinical outcome of expandable PEEK cages utilized for transforaminal lumbar interbody fusion in patients with lumbar degenerative diseases. Methods?Forty-nine patients who underwent lumbar interbody fusion with implantation of expandable PEEK cages and posterior instrumentation were included. The clinical outcome was evaluated using the visual analog scale (VAS) and the Oswestry Disability Index (ODI). Radiographic parameters including disk height, foraminal height, listhesis, local disk angle of the index level/levels, regional lumbar lordosis, and graft subsidence were measured preoperatively, postoperatively, and at latest follow-up. Results?At an average follow-up of 19.3 months, the minimum clinically important difference for the ODI and VAS back, buttock, and leg were achieved in 64, 52, 58, and 52% of the patients, respectively. There was statistically significant improvement in VAS back (6.42 versus 3.11, p?

  4. Fusion

    Microsoft Academic Search

    Robin Herman

    1990-01-01

    The book abounds with fascinating anecdotes about fusion's rocky path: the spurious claim by Argentine dictator Juan Peron in 1951 that his country had built a working fusion reactor, the rush by the United States to drop secrecy and publicize its fusion work as a propaganda offensive after the Russian success with Sputnik; the fortune Penthouse magazine publisher Bob Guccione

  5. Lateral Approach for Anterior Lumbar Interbody Fusion (XLIF and DLIF)

    Microsoft Academic Search

    Burak M. Ozgur; Lissa C. Baird

    \\u000a Since 1991, when Obenchain described the first laparoscopic lumbar discectomy [1], the field of minimally invasive spine surgery\\u000a has continued to evolve. Surgeon and patient alike have been attracted by the advantages of minimally invasive surgery, including\\u000a less tissue trauma during the surgical approach, less postoperative pain, shorter hospital stays, and faster return to activities\\u000a of daily living. These reported

  6. Fusion

    NASA Astrophysics Data System (ADS)

    Herman, Robin

    1990-10-01

    The book abounds with fascinating anecdotes about fusion's rocky path: the spurious claim by Argentine dictator Juan Peron in 1951 that his country had built a working fusion reactor, the rush by the United States to drop secrecy and publicize its fusion work as a propaganda offensive after the Russian success with Sputnik; the fortune Penthouse magazine publisher Bob Guccione sank into an unconventional fusion device, the skepticism that met an assertion by two University of Utah chemists in 1989 that they had created "cold fusion" in a bottle. Aimed at a general audience, the book describes the scientific basis of controlled fusion--the fusing of atomic nuclei, under conditions hotter than the sun, to release energy. Using personal recollections of scientists involved, it traces the history of this little-known international race that began during the Cold War in secret laboratories in the United States, Great Britain and the Soviet Union, and evolved into an astonishingly open collaboration between East and West.

  7. A prospective, randomised controlled trial of femoral ring allograft versus a titanium cage in circumferential lumbar spinal fusion with minimum 2-year clinical results

    Microsoft Academic Search

    Patrick J. McKenna; Brian J. C. Freeman; Robert C. Mulholland; Michael P. Grevitt; John K. Webb; S. H. Mehdian

    2005-01-01

    The literature reports on the safety and efficacy of titanium cages (TCs) with additional posterior fixation for anterior lumbar interbody fusion. However, these papers are limited to prospective cohort studies. The introduction of TCs for spinal fusion has resulted in increased costs, without evidence of superiority over the established practice. There are currently no prospective controlled trials comparing TCs to

  8. An ecology of text: using text retrieval to study alife on the net.

    PubMed

    Best, M L

    1997-01-01

    I introduce a new alife model, an ecology based on a corpus of text, and apply it to the analysis of posts to USENET News. In this corporal ecology posts are organisms, the newsgroups of NetNews define an environment, and human posters situated in their wider context make up a scarce resource. I apply latent semantic indexing (LSI), a text retrieval method based on principal component analysis, to distill from the corpus those replicating units of text. LSI arrives at suitable replicators because it discovers word co-occurrences that segregate and recombine with appreciable frequency. I argue that natural selection is necessarily in operation because sufficient conditions for its occurrence are met: replication, mutagenicity, and trait/fitness covariance. I describe a set of experiments performed on a static corpus of over 10,000 posts. In these experiments I study average population fitness, a fundamental element of population ecology. My study of fitness arrives at the unhappy discovery that a flame-war, centered around an overly prolific poster, is the king of the jungle. PMID:9654782

  9. Cost effectiveness of disc prosthesis versus lumbar fusion in patients with chronic low back pain: randomized controlled trial with 2-year follow-up

    Microsoft Academic Search

    Peter Fritzell; Svante Berg; Fredrik Borgström; Tycho Tullberg; Hans Tropp

    This randomized controlled health economic study assesses the cost-effectiveness of the concept of total disc replacement\\u000a (TDR) (Charité\\/Prodisc\\/Maverick) when compared with the concept of instrumented lumbar fusion (FUS) [posterior lumbar fusion\\u000a (PLF) \\/posterior lumbar interbody fusion (PLIF)]. Social and healthcare perspectives after 2 years are reported. In all, 152\\u000a patients were randomized to either TDR (n = 80) or lumbar FUS (n = 72). Cost

  10. Stability and Load Sharing Characteristics of a Posterior Dynamic Stabilization Device

    PubMed Central

    Cook, Daniel J.; Yeager, Matthew S.; Thampi, Shankar S.; Whiting, Donald M.

    2015-01-01

    Background Lumbar interbody fusion is a common treatment for a variety of spinal pathologies. It has been hypothesized that insufficient mechanical loading of the interbody graft can prevent proper fusion of the joint. The purpose of this study was to evaluate the mechanical stability and anterior column loading sharing characteristics of a posterior dynamic system compared to titanium rods in an anterior lumbar interbody fusion (ALIF) model. Methods Range of motion, interpedicular kinematics and interbody graft loading were measured in human cadaveric lumbar segments tested under a pure moment flexibility testing protocol. Results Both systems provided significant fixation compared to the intact condition and to an interbody spacer alone in flexion extension and lateral bending. No significant differences in fixation were detected between the devices. A significant decrease in graft loading was detected in flexion for the titanium rod treatment compared to spacer alone. No significant differences in graft loading were detected between the spacer alone and posterior dynamic system or between the posterior dynamic system and the titanium rod. Conclusions The results of this study indicate that the posterior dynamic system provides similar fixation compared to that of a titanium rod, however, studies designed to evaluate the efficacy of fixation in a cadaver model may not be sufficiently powered to establish differences in load sharing using the techniques described here.

  11. First report of major vascular injury due to lateral transpsoas approach leading to fatality.

    PubMed

    Assina, Rachid; Majmundar, Neil J; Herschman, Yehuda; Heary, Robert F

    2014-11-01

    Extreme lateral interbody fusion (XLIF) has gained popularity among spine surgeons for treating multiple conditions of the lumbar spine. In contrast to the anterior lumbar interbody fusion (ALIF) approach, the minimally invasive XLIF approach affords wide access to the lumbar disc space without an access surgeon and causes minimal tissue disruption. The XLIF approach offers many advantages over other lumbar spine approaches, with a reportedly low complication profile. The authors describe the first fatality reported in the literature following an XLIF approach. They describe the case of a 50-year-old woman who suffered a fatal intraoperative injury to the great vessels during a lateral transpsoas approach to the L4-5 disc space. PMID:25192374

  12. A Clinical Investigation of Contralateral Neurological Symptom after Transforaminal Lumbar Interbody Fusion (TLIF)

    PubMed Central

    Bai, Jiayue; Zhang, Wei; Zhang, Xin; Sun, Yapeng; Ding, Wenyuan; Shen, Yong

    2015-01-01

    Background The aim of this study was to analyze treatment outcomes and morbidity of contralateral neurological symptom in patients after TLIF surgery and to explore its possible causes. Material/Methods A retrospective study was conducted involving a total of 476 patients who underwent TILF from 2009 to 2012 in our hospital. These cases were divided into a symptomatic group (Group S) and a non-symptomatic group. The differences in contralateral foramen area and disc-height index(DHI) before and after surgery were compared between Group S and a random sample of 40 cases of non-symptomatic group patients (group N). In addition, according to whether the patient underwent second surgery, Group S patients were further divided into a transient neurologic symptoms group (Group T) and an operations exploration group (Group O). The time of symptom appearance, duration, and symptomatic severity (JOA VAS score) were compared between Group T and O. Results Among the 476 patients, 18 had postoperative contralateral neurological symptoms; thus, the morbidity was 3.7815%. The indicators in Group S were lower than in Group N in the differences in contralateral foramen area and disc-height index(DHI) before and after surgery (p<0.05). Five patients (Group O) in Group S had second surgery because of invalid conservative treatment. The surgical exploration rate was 1.0504%. Compared with Group T, the symptoms of Group O patients appeared earlier, persisted longer, and were more serious (p<0.05). Conclusions Contralateral neurological symptom is a potential complication after TLIF, and its causes are diverse. Surgical explorations should be conducted early for those patients with the complication who present with obvious nerve damage. PMID:26109143

  13. Coralline hydroxyapatite reinforced with polylactide fibres in lumbar interbody implantation.

    PubMed

    Ylinen, P; Raekallio, M; Taurio, R; Vihtonen, K; Vainionpää, S; Partio, E K; Törmälä, P; Rokkanen, P

    2005-04-01

    Porous hydroxyapatite HA blocks reinforced with poly-l/dl-lactide fibres were used to maintain the lumbar disc space and to start to create intercorporeal fusion in 23 growing pigs. In four pigs two emptied non adjacent disc spaces were left open. After 3, 6, 12 and 16 weeks the implanted disc blocks were studied radiologically, histologically, histomorphometrically, microradiographically, and with oxytetracycline fluorescence. In plain films slight to moderate ossification of the implanted disc spaces was detected at 12 and 16 weeks. Resorption of the implants was seen radiologically from 3 weeks and fragmentation from 12 weeks onwards. In microradiographs disintegration of the coralline inner structure started at 3 weeks. Histologically, connective tissue ingrowth was seen inside the porous structure from three weeks onwards. Small amounts of new bone were visible and connective tissue inside the implant increased from a mean of 65.6% at 3 weeks to a mean of 79.4% at 16 weeks histomorphometrically. The bone ingrowth varied from 0.7 to 1.7%. A loss of height in the implanted disc spaces was seen (p < 0.05, linear regression analysis). In control pigs the emptied disc spaces lost their height similarly. The implants used were not strong enough to maintain the lumbar disc height. PMID:15803277

  14. Magnetic resonance imaging on disc degeneration changes after implantation of an interspinous spacer and fusion of the adjacent segment

    PubMed Central

    Liu, Xiaokang; Liu, Yingjie; Lian, Xiaofeng; Xu, Jianguang

    2015-01-01

    The aim of the study was to investigate the changes of the lumbar intervertebral disc degeneration by magnetic resonance imaging (MRI) after the implantation of interspinous device and the fusion of the adjacent segment. A total of 62 consecutive patients suffering L5/S1 lumbar disc herniation (LDH) with concomitant disc space narrowing or low-grade instability up to 5 mm translational slip in L5/S1 level were treated with lumbar interbody fusion (LIF) via posterior approach. Thirty-four of these patients (Coflex group) received an additional implantation of the interspinous spacer device (Coflex™) in the level L4/L5, while the rest of 28 patients (fusion group) underwent the fusion surgery alone. Clinical and radiographic examinations were performed at pre- and postoperative visits to compare the clinical outcomes and the changes of the L4/L5 vertebral disc degeneration on MRI in both Coflex and fusion group. Although both Coflex and fusion group showed improvements of the clinical outcomes assessed by the Oswestry Disability Index (ODI) after surgery, patients in Coflex group had more significant amelioration (P < 0.05) compared to fusion group. During follow up, the postoperative disc degeneration changes in Coflex group assessed by the relative signal intensity (RSI) differed from those in fusion group (P < 0.05). The supplemental implantation of Coflex™ after the fusion surgery could delay the disc degeneration of the adjacent segment.

  15. Changes in Neuroforaminal Height with 2 Level Axial Presacral Lumbar Interbody Fusion at L4-S1

    PubMed Central

    Marawar, Satyajit; Jung, Jin; Sun, Mike

    2014-01-01

    Background The objective was to examine the changes in neuroforaminal height at L4-L5 and L5-S1 after insertion and graduated foraminal distraction using the 2 level transsacral implant in a cadaveric model. Methods Discectomy and transsacral instrumentation was performed in six fresh human cadavers at L4-S1. The neuroforaminal height was measured at L4-L5 and L5-S1 before and after insertion of the implant and then at each stage of manual distraction. Results Mean L4-5 neuroforaminal height increased from 18.2 ± 3.1mm to 20.3± 2.9mm (11%) on the left and from 18.8±2.8mm to 20.6± 2.3mm (12%) on the right (P<0.05). Mean L5-S1 neuroforaminal height increased from 15.7±3.0mm to 18.4 ±2.8mm (17%) on the left and from 15.6 ±2.1mm to 18.3 ±1.8mm (17%) on the right (P<0.05). When the neuroforaminal height was plotted against amount of rotation of the screw driver it was found that the neuroforaminal height at L5-S1 increased by 1mm on average for every complete revolution of the screw driver. At least 2 full rotations of the screw driver were achieved in all cadavers. Conclusions The transsacral screw construct distracted the disc space and neuroforaminal height in a cadaveric spine model without soft tissue envelope. During the initial process, manual control of disc space distraction predictably correlated with the increase in the neuroforaminal height to a maximum. However, further research is needed to look at variables affecting disc space pliability, implant subsidence, in vivo application, and clinical benefit of this procedure. PMID:25694937

  16. Fusion Basics

    NSDL National Science Digital Library

    This website from the Princeton Plasma Physics Laboratory provides background information about fusion. Different sections cover fusion reactions, plasma heating, and how a fusion power plant would work. In addition, the site offers links to research projects at the Princeton Plasma Physics Laboratory.

  17. Fusion breeder

    SciTech Connect

    Moir, R.W.

    1982-02-22

    The fusion breeder is a fusion reactor designed with special blankets to maximize the transmutation by 14 MeV neutrons of uranium-238 to plutonium or thorium to uranium-233 for use as a fuel for fission reactors. Breeding fissile fuels has not been a goal of the US fusion energy program. This paper suggests it is time for a policy change to make the fusion breeder a goal of the US fusion program and the US nuclear energy program. The purpose of this paper is to suggest this policy change be made and tell why it should be made, and to outline specific research and development goals so that the fusion breeder will be developed in time to meet fissile fuel needs.

  18. Revision of anterior cervical pseudoarthrosis with anterior allograft fusion and plating.

    PubMed

    Coric, D; Branch, C L; Jenkins, J D

    1997-06-01

    Anterior cervical discectomy and fusion is an efficacious procedure used to treat a variety of cervical spinal disorders, including spondylosis, myelopathy, herniated discs, trauma, and degenerative disc disease. Pseudarthrosis, or failure of fusion, may be the most common complication of spinal fusion procedures. Nineteen consecutive patients with symptomatic pseudarthrosis following failed anterior cervical fusions were treated with anterior cervical revision using iliac crest allografts and either the Cervical Spine Locking Plate system (10 patients) or the Trapezial Osteosynthetic Plate system (nine patients). The mean age of the nine men and 10 women undergoing treatment was 49.1 years (range 25-72 years). Eleven patients (57.9%) exhibited pseudarthrosis at one level, six (31.5%) at two levels, and two (10.5%) at three levels. The indications for revision were intractable neck pain with radiculopathy (17 patients) or myelopathy (two patients), with evidence of pseudarthrosis on plain cervical radiography as well as computerized tomography (CT) or single-photon emission computerized tomography (SPECT) scanning, or both. All eight patients evaluated with SPECT showed increased focal uptake consistent with pseudarthrosis, which was subsequently confirmed intraoperatively in all eight. The average follow-up period was 22.4 months (range 12-42 months). Solid osseous fusion was achieved over all 28 levels in all 18 patients available for follow-up review (100%). One patient died 4 months postoperatively from myocardial infarction related to preexisting coronary artery disease. There were no intraoperative complications; postoperatively, two patients (10.5%) experienced transient hoarseness. Anterior revision of failed cervical fusions using allograft interbody fusion material and anterior plating is a safe and efficacious procedure. In this series, the use of allografts avoided donor site morbidity without adversely affecting fusion rates. Rigid internal fixation was achieved by means of anterior plating without increasing surgical morbidity rates. The SPECT imaging technique has the potential to reliably confirm the diagnosis of pseudarthrosis. PMID:9171175

  19. Fusion Implementation

    SciTech Connect

    J.A. Schmidt

    2002-02-20

    If a fusion DEMO reactor can be brought into operation during the first half of this century, fusion power production can have a significant impact on carbon dioxide production during the latter half of the century. An assessment of fusion implementation scenarios shows that the resource demands and waste production associated with these scenarios are manageable factors. If fusion is implemented during the latter half of this century it will be one element of a portfolio of (hopefully) carbon dioxide limiting sources of electrical power. It is time to assess the regional implications of fusion power implementation. An important attribute of fusion power is the wide range of possible regions of the country, or countries in the world, where power plants can be located. Unlike most renewable energy options, fusion energy will function within a local distribution system and not require costly, and difficult, long distance transmission systems. For example, the East Coast of the United States is a prime candidate for fusion power deployment by virtue of its distance from renewable energy sources. As fossil fuels become less and less available as an energy option, the transmission of energy across bodies of water will become very expensive. On a global scale, fusion power will be particularly attractive for regions separated from sources of renewable energy by oceans.

  20. Assisted fusion

    E-print Network

    German Kälbermann

    2009-10-19

    A model of nuclear fusion consisting of a wave packet impinging into a well located between square one dimensional barriers is treated analytically. The wave function inside the well is calculated exactly for the assisted tunneling induced by a perturbation mimicking a constant electric field with arbitrary time dependence. Conditions are found for the enhancement of fusion.

  1. Image fusion

    NASA Technical Reports Server (NTRS)

    Pavel, M.

    1993-01-01

    The topics covered include the following: a system overview of the basic components of a system designed to improve the ability of a pilot to fly through low-visibility conditions such as fog; the role of visual sciences; fusion issues; sensor characterization; sources of information; image processing; and image fusion.

  2. In vivo experimental study of hat type cervical intervertebral fusion cage (HCIFC).

    PubMed

    Gu, Yu-tong; Yao, Zhen-jun; Jia, Lian-shun; Qi, Jin; Wang, Jun

    2010-12-01

    The purpose of this study was to compare the characteristics of interbody fusion achieved using the hat type cervical intervertebral fusion cage (HCIFC) with those of an autologous tricortical iliac crest graft, Harms cage and the carbon cage in a goat cervical spine model. Thirty-two goats underwent C3-4 discectomy and fusion. They were subdivided into four groups of eight goats each: group 1, autologous tricortical iliac crest bone graft; group 2, Harms cage filled with autologous iliac crest graft; group 3, carbon cage filled with autologous iliac bone; and group 4, HCIFC filled with autologous iliac graft. Radiography was performed pre- and postoperatively and after one, two, four, eight and 12 weeks. At the same time points, disc space height, intervertebral angle, and lordosis angle were measured. After 12 weeks, the goats were killed and fusion sites were harvested. Biomechanical testing was performed in flexion, extension, axial rotation, and lateral bending to determine the stiffness and range of motion. All cervical fusion specimens underwent histomorphological analyses. One week after operation, the disc space height (DSH), intervertebral angle (IVA) and lordosis angle (LA) of HCIFC and carbon cage were statistically greater than those of autologous iliac bone graft and Harms cage. Significantly higher values for DSH, IVA and LA were shown in cage-treated goats than in those that received bone graft over a 12-week period. The stiffness of Harms cage in axial rotation and lateral bending were statistically greater than that of other groups. Radiographic and histomorphological evaluation showed better fusion results in the cage groups than in the autologous bone group. HCIFC can provide a good intervertebral distractability and sufficient biomechanical stability for cervical fusion. PMID:20195596

  3. In vivo experimental study of hat type cervical intervertebral fusion cage (HCIFC)

    PubMed Central

    Yao, Zhen-jun; Jia, Lian-shun; Qi, Jin; Wang, Jun

    2010-01-01

    The purpose of this study was to compare the characteristics of interbody fusion achieved using the hat type cervical intervertebral fusion cage (HCIFC) with those of an autologous tricortical iliac crest graft, Harms cage and the carbon cage in a goat cervical spine model. Thirty-two goats underwent C3-4 discectomy and fusion. They were subdivided into four groups of eight goats each: group 1, autologous tricortical iliac crest bone graft; group 2, Harms cage filled with autologous iliac crest graft; group 3, carbon cage filled with autologous iliac bone; and group 4, HCIFC filled with autologous iliac graft. Radiography was performed pre- and postoperatively and after one, two, four, eight and 12 weeks. At the same time points, disc space height, intervertebral angle, and lordosis angle were measured. After 12 weeks, the goats were killed and fusion sites were harvested. Biomechanical testing was performed in flexion, extension, axial rotation, and lateral bending to determine the stiffness and range of motion. All cervical fusion specimens underwent histomorphological analyses. One week after operation, the disc space height (DSH), intervertebral angle (IVA) and lordosis angle (LA) of HCIFC and carbon cage were statistically greater than those of autologous iliac bone graft and Harms cage. Significantly higher values for DSH, IVA and LA were shown in cage-treated goats than in those that received bone graft over a 12-week period. The stiffness of Harms cage in axial rotation and lateral bending were statistically greater than that of other groups. Radiographic and histomorphological evaluation showed better fusion results in the cage groups than in the autologous bone group. HCIFC can provide a good intervertebral distractability and sufficient biomechanical stability for cervical fusion. PMID:20195596

  4. Anterior lumbar interbody surgery for spondylosis results from a classically-trained neurosurgeon.

    PubMed

    Chatha, Gurkirat; Foo, Stacy W L; Lind, Christopher R P; Budgeon, Charley; Bannan, Paul E

    2014-09-01

    Anterior lumbar surgery for degenerative disc disease (DDD) is a relatively novel technique that can prevent damage to posterior osseous, muscular and ligamentous spinal elements. This study reports the outcomes and complications in 286 patients who underwent fusion - with artificial disc implants or combined fusion and artificial disc implants - by a single-operator neurosurgeon, with up to 24 months of follow-up. The visual analogue scale (VAS), Oswestry Disability Index (ODI), Short Form 36 (SF36) and prospective log of adverse events were used to assess the clinical outcome. Radiographic assessments of implant position and bony fusion were analysed. Intraoperative and postoperative complications were also recorded. Irrespective of pre-surgical symptoms (back pain alone or back and leg pain combined), workers' compensation status and type of surgical implant, clinically significant improvements in VAS, ODI and SF36 were primarily observed at 3 and/or 6 month follow-up, and improvements were maintained at 24 months after surgery. A 94% fusion rate was obtained; the overall complication was 9.8% which included 3.5% with vascular complications. The anterior lumbar approach can be used for treating DDD for both back pain and back and leg pain with low complication rates. With appropriate training, single-operator neurosurgeons can safely perform these surgeries. PMID:24786717

  5. Fusion Power.

    ERIC Educational Resources Information Center

    Dingee, David A.

    1979-01-01

    Discusses the extraordinary potential, the technical difficulties, and the financial problems that are associated with research and development of fusion power plants as a major source of energy. (GA)

  6. Spinal fusion

    MedlinePLUS

    ... the spine. Other surgery, such as a diskectomy , laminectomy , or a foraminotomy , is almost always done first. ... procedures for spinal stenosis , such as foraminotomy or laminectomy After diskectomy in the neck Spinal fusion may ...

  7. Fusion Simulation

    NSDL National Science Digital Library

    In this activity, kids are able to see with their own eyes how fusion works. The simple experiment requires only Velcro and two strong magnets.The activity begins with a brief overview that introduces students to the science they are about to see. Then, the procedure is laid out in simple step-by-step directions. The activity ends with an explanation that gives students a deeper understanding of how what they've just witnessed relates to fusion.

  8. Current strategies for the restoration of adequate lordosis during lumbar fusion

    PubMed Central

    Barrey, Cédric; Darnis, Alice

    2015-01-01

    Not restoring the adequate lumbar lordosis during lumbar fusion surgery may result in mechanical low back pain, sagittal unbalance and adjacent segment degeneration. The objective of this work is to describe the current strategies and concepts for restoration of adequate lordosis during fusion surgery. Theoretical lordosis can be evaluated from the measurement of the pelvic incidence and from the analysis of spatial organization of the lumbar spine with 2/3 of the lordosis given by the L4-S1 segment and 85% by the L3-S1 segment. Technical aspects involve patient positioning on the operating table, release maneuvers, type of instrumentation used (rod, screw-rod connection, interbody cages), surgical sequence and the overall surgical strategy. Spinal osteotomies may be required in case of fixed kyphotic spine. AP combined surgery is particularly efficient in restoring lordosis at L5-S1 level and should be recommended. Finally, not one but several strategies may be used to achieve the need for restoration of adequate lordosis during fusion surgery. PMID:25621216

  9. External transpedicular fixation test of the lumbar spine correlates with the outcome of subsequent lumbar fusion.

    PubMed

    Soini, J; Slätis, P; Kannisto, M; Sandelin, J

    1993-08-01

    External transpedicular fixation was applied to the lower lumbar spine in a prospective study on 42 patients with chronic low back pain combined with suspected instability of the lumbar segments; the diagnosis was failed disk surgery, spondylolisthesis, and degenerative disk disease. The aim was to realign the involved segments, to restore disk height, and to record changes in pain and performance during the external fixation test. Pain was recorded on a visual analog scale, and performance was assessed using the Oswestry disability score. As independent observer assessed the test and treatment results. Twenty-nine patients experienced relief of pain and performed better in the fixator; they were subjected to anterior interbody fusion, the external frame being kept as a stabilizing device for an additional four months. Twenty-two patients have had follow-up evaluations for two years. One and two years after successful lumbar fusion, significantly (p < 0.02) better pain and performance scores were recorded; the results of lumbar fusion corresponded to the preoperative fixation test. A temporary external fixation test may be a useful procedure in patients considered for subsequent spondylodesis. PMID:8339515

  10. Current strategies for the restoration of adequate lordosis during lumbar fusion.

    PubMed

    Barrey, Cédric; Darnis, Alice

    2015-01-18

    Not restoring the adequate lumbar lordosis during lumbar fusion surgery may result in mechanical low back pain, sagittal unbalance and adjacent segment degeneration. The objective of this work is to describe the current strategies and concepts for restoration of adequate lordosis during fusion surgery. Theoretical lordosis can be evaluated from the measurement of the pelvic incidence and from the analysis of spatial organization of the lumbar spine with 2/3 of the lordosis given by the L4-S1 segment and 85% by the L3-S1 segment. Technical aspects involve patient positioning on the operating table, release maneuvers, type of instrumentation used (rod, screw-rod connection, interbody cages), surgical sequence and the overall surgical strategy. Spinal osteotomies may be required in case of fixed kyphotic spine. AP combined surgery is particularly efficient in restoring lordosis at L5-S1 level and should be recommended. Finally, not one but several strategies may be used to achieve the need for restoration of adequate lordosis during fusion surgery. PMID:25621216

  11. Osteoconductive hydroxyapatite coated PEEK for spinal fusion surgery

    NASA Astrophysics Data System (ADS)

    Hahn, Byung-Dong; Park, Dong-Soo; Choi, Jong-Jin; Ryu, Jungho; Yoon, Woon-Ha; Choi, Joon-Hwan; Kim, Jong-Woo; Ahn, Cheol-Woo; Kim, Hyoun-Ee; Yoon, Byung-Ho; Jung, In-Kwon

    2013-10-01

    Polyetheretherketone (PEEK) has attracted much interest as biomaterial for interbody fusion cages due to its similar stiffness to bone and good radio-transparency for post-op visualization. Hydroxyapatite (HA) coating stimulates bone growth to the medical implant. The objective of this work is to make an implant consisting of biocompatible PEEK with an osteoconductive HA surface for spinal or orthopedic applications. Highly dense and well-adhered HA coating was developed on medical-grade PEEK using aerosol deposition (AD) without thermal degradation of the PEEK. The HA coating had a dense microstructure with no cracks or pores, and showed good adhesion to PEEK at adhesion strengths above 14.3 MPa. The crystallinity of the HA coating was remarkably enhanced by hydrothermal annealing as post-deposition heat-treatment. In addition, in vitro and in vivo biocompatibility of PEEK, in terms of cell adhesion morphology, cell proliferation, differentiation, and bone-to-implant contact ratio, were remarkably enhanced by the HA coating through AD.

  12. Cold fusion, Alchemist's dream

    SciTech Connect

    Clayton, E.D.

    1989-09-01

    In this report the following topics relating to cold fusion are discussed: muon catalysed cold fusion; piezonuclear fusion; sundry explanations pertaining to cold fusion; cosmic ray muon catalysed cold fusion; vibrational mechanisms in excited states of D{sub 2} molecules; barrier penetration probabilities within the hydrogenated metal lattice/piezonuclear fusion; branching ratios of D{sub 2} fusion at low energies; fusion of deuterons into {sup 4}He; secondary D+T fusion within the hydrogenated metal lattice; {sup 3}He to {sup 4}He ratio within the metal lattice; shock induced fusion; and anomalously high isotopic ratios of {sup 3}He/{sup 4}He.

  13. Data fusion

    Microsoft Academic Search

    Jens Bleiholder; Felix Naumann

    2008-01-01

    The development of the Internet in recent years has made it possible and useful to access many different information systems anywhere in the world to obtain information. While there is much research on the integration of heterogeneous information systems, most commercial systems stop short of the actual integration of available data. Data fusion is the process of fusing multiple records

  14. Nuclear Fusion

    NSDL National Science Digital Library

    Astronomical Society of the Pacific

    2008-01-01

    This simple and engaging astronomy activity explains nuclear fusion and how radiation is generated by stars, using marshmallows as a model. Learners will explore what cosmic radiation is and where it comes from, and how the elements in the universe are generated. The PDF contains step-by-step instructions, photos, presentation tips, links to background information, and a printable Periodic Table of the Elements.

  15. Distributed information fusion agents

    Microsoft Academic Search

    Don Perugini; Dale Lambert; Leon Sterling; Adrian Pearce

    2003-01-01

    Information fusion is typically data driven and applied to adversarial contexts. Advantages of a goal driven fusion process are emerging. An agent approach to fusion applied to friendly contexts, such as logistics, is presented. Agents are suitable for fusion because they can represent autonomous fusion eritities by modelling their capabilities, expertise and intentions. This paper promotes a level 3 centric

  16. data fusion 15 June 2012

    E-print Network

    Dobigeon, Nicolas

    real world data fusion Fred Daum 15 June 2012 data fusion Copyright © 2012 Raytheon Company. All fusion fusion of measurements performance fusion of tracks interesting parameter 3 #12;real world multi-sensor data fusion fusion of tracks performance fusion of measurements interesting parameter 4 #12;real world

  17. Occipitocervical fusion.

    PubMed

    Garrido, Ben J; Sasso, Rick C

    2012-01-01

    The evolution of occipitocervical fixation and new rigid universal screw-rod construct technology has allowed secure anchorage at each level of the occipitocervical junction with the elimination of rigid external orthoses. Rigid occipitocervical instrumentation constructs have achieved higher fusion rates and less postoperative immobilization-associated complications. Outcomes have improved compared with former nonrigid instrumentation techniques; however, with advances of rigid occipitocervical stabilization capability have come new challenges, risks, and operative techniques. A thorough understanding of the relevant cervical bony and soft tissue anatomy is essential for safe implantation and a successful outcome. PMID:22082624

  18. Fusion Science Education Outreach

    Microsoft Academic Search

    C. A. Danielson

    1996-01-01

    This presentation will focus on education outreach activities at General Atomics that have been expanded to include the general population on science education with a focus on fusion energy. Outreach materials are distributed upon request both nationally and internationally. These materials include a notebook containing copies of DIII--D tour panels, fusion poster, new fusion energy video, new fusion energy brochure,

  19. Porous titanium-6 aluminum-4 vanadium cage has better osseointegration and less micromotion than a poly-ether-ether-ketone cage in sheep vertebral fusion.

    PubMed

    Wu, Su-Hua; Li, Yi; Zhang, Yong-Quan; Li, Xiao-Kang; Yuan, Chao-Fan; Hao, Yu-Lin; Zhang, Zhi-Yong; Guo, Zheng

    2013-12-01

    Interbody fusion cages made of poly-ether-ether-ketone (PEEK) have been widely used in clinics for spinal disorders treatment; however, they do not integrate well with surrounding bone tissue. Ti-6Al-4V (Ti) has demonstrated greater osteoconductivity than PEEK, but the traditional Ti cage is generally limited by its much greater elastic modulus (110?GPa) than natural bone (0.05-30?GPa). In this study, we developed a porous Ti cage using electron beam melting (EBM) technique to reduce its elastic modulus and compared its spinal fusion efficacy with a PEEK cage in a preclinical sheep anterior cervical fusion model. A porous Ti cage possesses a fully interconnected porous structure (porosity: 68?±?5.3%; pore size: 710?±?42??m) and a similar Young's modulus as natural bone (2.5?±?0.2?GPa). When implanted in vivo, the porous Ti cage promoted fast bone ingrowth, achieving similar bone volume fraction at 6 months as the PEEK cage without autograft transplantation. Moreover, it promoted better osteointegration with higher degree (2-10x) of bone-material binding, demonstrated by histomorphometrical analysis, and significantly higher mechanical stability (P?

  20. Harvesting local cylinder autograft from adjacent vertebral body for anterior lumbar interbody fusion: surgical technique, operative feasibility and preliminary clinical results

    Microsoft Academic Search

    Vincent Arlet; Liang Jiang; Thomas Steffen; Jean Ouellet; Rudy Reindl; Max Aebi

    2006-01-01

    Autogenous iliac crest has long served as the gold standard for anterior lumbar arthrodesis although added morbidity results from the bone graft harvest. Therefore, femoral ring allograft, or cages, have been used to decrease the morbidity of iliac crest bone harvesting. More recently, an experimental study in the animal showed that harvesting local bone from the anterior vertebral body and

  1. Bemerkungen zur "kalten Fusion"

    E-print Network

    Kuehne, R W

    2006-01-01

    Steven Jones et al. reported to have observed nuclear fusion at room temperature. They observed this "cold fusion" by electrolyzing heavy water. Later experiments confirmed these observations. These experiments confirmed the generation of strong electric fields within the deuterided metals. These electric fields accelerate the deuterons to keV energies and allow the observed nuclear fusion. Roman Sioda and I suggested a theoretical description of this nuclear fusion. Our "extended micro hot fusion" scenario explains how nuclear fusion can be generated over a long time within deuterided metals. Moreover we predicted the explosion of large pieces of deuterided metals. This article reviews the "cold fusion" work of Steven Jones et al. and discusses the fracto-fusion scenario. I show that the extended micro hot fusion scenario can explain the observed neutron emissions, neutron bursts, and heat bursts.

  2. Fusion energy

    SciTech Connect

    Not Available

    1990-09-01

    The main purpose of the International Thermonuclear Experimental Reactor (ITER) is to develop an experimental fusion reactor through the united efforts of many technologically advanced countries. The ITER terms of reference, issued jointly by the European Community, Japan, the USSR, and the United States, call for an integrated international design activity and constitute the basis of current activities. Joint work on ITER is carried out under the auspices of the International Atomic Energy Agency (IAEA), according to the terms of quadripartite agreement reached between the European Community, Japan, the USSR, and the United States. The site for joint technical work sessions is at the MaxPlanck Institute of Plasma Physics. Garching, Federal Republic of Germany. The ITER activities have two phases: a definition phase performed in 1988 and the present design phase (1989--1990). During the definition phase, a set of ITER technical characteristics and supporting research and development (R D) activities were developed and reported. The present conceptual design phase of ITER lasts until the end of 1990. The objectives of this phase are to develop the design of ITER, perform a safety and environmental analysis, develop site requirements, define future R D needs, and estimate cost, manpower, and schedule for construction and operation. A final report will be submitted at the end of 1990. This paper summarizes progress in the ITER program during the 1989 design phase.

  3. Cold fusion

    SciTech Connect

    Bush, R.T. (California State Polytechnic Univ., Physics Dept., Pomona, CA (US))

    1991-03-01

    The transmission resonance model (TRM) is combined with some electrochemistry of the cathode surface and found to provide a good fit to new data on excess heat. For the first time, a model for cold fusion not only fits calorimetric data but also predicts optimal trigger points. This suggests that the model is meaningful and that the excess heat phenomenon claimed by Fleischmann and Pons is genuine. A crucial role is suggested for the overpotential and, in particular, for the concentration overpotential, i.e., the hydrogen overvoltage. Self-similar geometry, or scale invariance, i.e., a fractal nature, is revealed by the relative excess power function. Heat bursts are predicted with a scale invariance in time, suggesting a possible link between the TRM and chaos theory. The model describes a near-surface phenomenon with an estimated excess power yield of {approximately}1 kW/cm{sup 3} Pd, as compared to 50 W/cm{sup 3} of reactor core for a good fission reactor. Transmission resonance-induced nuclear transmutation, a new type of nuclear reaction, is strongly suggested with two types emphasized: transmission resonance-induced neutron transfer reactions yielding essentially the same end result as Teller's hypothesized catalytic neutron transfer and a three-body reaction promoted by standing de Broglie waves. In this paper suggestions for the anomalous production of heat, particles, and radiation are given.

  4. Fusion energy

    NASA Astrophysics Data System (ADS)

    1990-09-01

    The main purpose of the International Thermonuclear Experimental Reactor (ITER) is to develop an experimental fusion reactor through the united efforts of many technologically advanced countries. The ITER terms of reference, issued jointly by the European Community, Japan, the USSR, and the United States, call for an integrated international design activity and constitute the basis of current activities. Joint work on ITER is carried out under the auspices of the International Atomic Energy Agency (IAEA), according to the terms of quadripartite agreement reached between the European Community, Japan, the USSR, and the United States. The site for joint technical work sessions is at the Max Planck Institute of Plasma Physics. Garching, Federal Republic of Germany. The ITER activities have two phases: a definition phase performed in 1988 and the present design phase (1989 to 1990). During the definition phase, a set of ITER technical characteristics and supporting research and development (R and D) activities were developed and reported. The present conceptual design phase of ITER lasts until the end of 1990. The objectives of this phase are to develop the design of ITER, perform a safety and environmental analysis, develop site requirements, define future R and D needs, and estimate cost, manpower, and schedule for construction and operation. A final report will be submitted at the end of 1990. This paper summarizes progress in the ITER program during the 1989 design phase.

  5. Review of fusion synfuels

    SciTech Connect

    Fillo, J.A.

    1980-01-01

    Thermonuclear fusion offers an inexhaustible source of energy for the production of hydrogen from water. Depending on design, electric generation efficiencies of approx. 40 to 60% and hydrogen production efficiencies by high-temperature electrolysis of approx. 50 to 65% are projected for fusion reactors using high-temperatures blankets. Fusion/coal symbiotic systems appear economically promising for the first generation of commercial fusion synfuels plants. Coal production requirements and the environmental effects of large-scale coal usage would be greatly reduced by a fusion/coal system. In the long term, there could be a gradual transition to an inexhaustible energy system based solely on fusion.

  6. Fusion Power Associates, 2011 Annual Meeting 1 General Fusion

    E-print Network

    Fusion Power Associates, 2011 Annual Meeting 1 General Fusion #12;Fusion Power Associates, 2011 Annual Meeting 2 General Fusion Making commercially viable fusion power a reality. · Founded in 2002, based in Vancouver, Canada · Plan to demonstrate a fusion system capable of "net gain" within 3 years

  7. Fusion Power Associates, 2012 Annual Meeting 1 General Fusion

    E-print Network

    Fusion Power Associates, 2012 Annual Meeting 1 General Fusion #12;Fusion Power Associates, 2012 Annual Meeting 2 General Fusion Making affordable fusion power a reality. · Founded in 2002, based to demonstrate the first fusion system capable of "net gain" 3 years after proof · Validated by leading experts

  8. FUSION NUCLEAR SCIENCE PROGRAM & SUPPORTING FUSION NUCLEAR SCIENCE FACILITY (FNSF)

    E-print Network

    irradiation effects on materials Harnessing Fusion Power · Fusion power extraction and tritium breedingFUSION NUCLEAR SCIENCE PROGRAM & SUPPORTING FUSION NUCLEAR SCIENCE FACILITY (FNSF): UPDATE and plasma contamination are required. 4. Harnessing Fusion Power Fusion energy from deuterium-tritium (D

  9. ChemTeacher: Fusion

    NSDL National Science Digital Library

    2011-01-01

    ChemTeacher compiles background information, videos, articles, demonstrations, worksheets and activities for high school teachers to use in their classrooms. The Fusion page includes resources for teaching students about the discovery and applications of fusion.

  10. Fusion Energy Sciences Program Mission

    E-print Network

    Fusion Energy Sciences Program Mission The Fusion Energy Sciences (FES) program leads the national research effort to advance plasma science, fusion science, and fusion technology--the knowledge base needed for an economically and environmentally attractive fusion energy source. The National Energy Policy states that fusion

  11. Limited access surgery for 360 degrees in-situ fusion in a dysraphic patient with high-grade spondylolisthesis.

    PubMed

    König, M A; Boszczyk, B M

    2012-03-01

    Progressive high-grade spondylolisthesis can lead to spinal imbalance. High-grade spondylolisthesis is often reduced and fused in unbalanced pelvises, whereas in-situ fusion is used more often in balanced patients. The surgical goal is to recreate or maintain sagittal balance but if anatomical reduction is necessary, the risk of nerval damage with nerve root disruption in worst cases is increased. Spinal dysraphism like spina bifida or tethered cord syndrome make it very difficult to achieve reduction and posterior fusion due to altered anatomy putting the focus on anterior column support. Intensive neural structure manipulation should be avoided to reduce neurological complications and re-tethering in these cases. A 26-year-old patient with a history of diastematomyelia, occult spina bifida and tethered cord syndrome presented with new onset of severe low back pain, and bilateral L5/S1 sciatica after a fall. The X-ray demonstrated a grade III spondylolisthesis with spina bifida and the MRI scan revealed bilateral severely narrowed exit foramina L5 due to the listhesis. Because she was well balanced sagittally, the decision for in-situ fusion was made to minimise the risk of neurological disturbance through reduction. Anterior fusion was favoured to minimise manipulation of the dysraphic neural structures. Fusion was achieved via isolated access to the L4/L5 disc space. A L5 transvertebral hollow modular anchorage (HMA) screw was passed into the sacrum from the L4/L5 disc space and interbody fusion of L4/L5 was performed with a cage. The construct was augmented with pedicle screw fixation L4-S1 via a less invasive bilateral muscle split for better anterior biomechanical support. The postoperative course was uneventful and fusion was CT confirmed at the 6-month follow-up. At the last follow-up, she worked full time, was completely pain free and not limited in her free-time activities. The simultaneous presence of high-grade spondylolisthesis and spinal dysraphism make it very difficult to find a decisive treatment plan because both posterior and anterior treatment strategies have advantages and disadvantages in these challenging cases. The described technique combines several surgical options to achieve 360° fusion with limited access, reducing the risk of neurological sequelae. PMID:22008862

  12. Slow liner fusion

    SciTech Connect

    Shaffer, M.J.

    1997-08-01

    {open_quotes}Slow{close_quotes} liner fusion ({approximately}10 ms compression time) implosions are nondestructive and make repetitive ({approximately} 1 Hz) pulsed liner fusion reactors possible. This paper summarizes a General Atomics physics-based fusion reactor study that showed slow liner feasibility, even with conservative open-line axial magnetic field confinement and Bohm radial transport.

  13. Magnetized target fusion and fusion propulsion.

    SciTech Connect

    Kirkpatrick, R. C. (Ronald C.)

    2001-01-01

    Magnetized target fusion (MTF) is a thermonuclear fusion concept that is intermediate between the two mainline approaches, magnetic confinement and inertial confinement fusion (MCF and ICF). MTF incorporates some aspects of each and offers advantages over each of the mainline approaches. First, it provides a means of reducing the driver power requirements, thereby admitting a wider range of drivers than ICF. Second, the magnetic field is only used for insulation, not confinement, and the plasma is wall confined, so that plasma instabilities are traded in for hydrodynamic instabilities. However, the degree of compression required to reach fusion conditions is lower than for ICF, so that hydrodynamic instabilities are much less threatening. The standoff driver innovation proposes to dynamically form the target plasma and a gaseous shell that compresses and confines the target plasma. Therefore, fusion target fabrication is traded in for a multiplicity of plasma guns, which must work in synchrony. The standoff driver embodiment of MTF leads to a fusion propulsion system concept that is potentially compact and lightweight. We will discuss the underlying physics of MTF and some of the details of the fusion propulsion concept using the standoff driver approach. We discuss here the optimization of an MTF target design for space propulsion.

  14. In-vitro MRI detectability of interbody test spacers made of carbon fibre-reinforced polymers, titanium and titanium-coated carbon fibre-reinforced polymers.

    PubMed

    Ernstberger, Thorsten; Buchhorn, Gottfried; Baums, Mike Herbert; Heidrich, Gabert

    2007-04-01

    The purpose of this study was to investigate how different materials affect the magnetic resonance imaging (MRI) detectability of interbody test spacers (ITS). We evaluated the post-implantation MRI scans with T1 TSE sequences for three different ITS made of titanium, carbon fibre-reinforced polymers (CFRP) and titanium-coated CFRP, respectively. The main target variables were total artefact volume (TAV) and median artefact area (MAA). Additionally, implant volume (IV)/TAV and cross section (CS)/MAA ratio were determined. The t test and Newman-Keuls test for multiple comparisons were used for statistical analysis. TAV and MAA did not differ significantly between CFRP and titanium-coated CFRP, but were approximately twice as high for the titanium ITS (p < 0.001). MRI detectability was optimum for CFRP and titanium-coated CFRP, but was limited at the implant-bone interface of the titanium ITS. The material's susceptibility and the implant's dimensions affected MRI artefacting. Based on TAV, the volume of titanium surface coating in the ITS studied has no influence on susceptibility in MRI scans with T1 TSE sequences. PMID:17515239

  15. The fusion breeder

    NASA Astrophysics Data System (ADS)

    Moir, Ralph W.

    1982-10-01

    The fusion breeder is a fusion reactor designed with special blankets to maximize the transmutation by 14 MeV neutrons of uranium-238 to plutonium or thorium to uranium-233 for use as a fuel for fission reactors. Breeding fissile fuels has not been a goal of the U.S. fusion energy program. This paper suggests it is time for a policy change to make the fusion breeder a goal of the U.S. fusion program and the U.S. nuclear energy program. There is wide agreement that many approaches will work and will produce fuel for five equal-sized LWRs, and some approach as many as 20 LWRs at electricity costs within 20% of those at today's price of uranium (30/lb of U3O8). The blankets designed to suppress fissioning, called symbiotes, fusion fuel factories, or just fusion breeders, will have safety characteristics more like pure fusion reactors and will support as many as 15 equal power LWRs. The blankets designed to maximize fast fission of fertile material will have safety characteristics more like fission reactors and will support 5 LWRs. This author strongly recommends development of the fission suppressed blanket type, a point of view not agreed upon by everyone. There is, however, wide agreement that, to meet the market price for uranium which would result in LWR electricity within 20% of today's cost with either blanket type, fusion components can cost severalfold more than would be allowed for pure fusion to meet the goal of making electricity alone at 20% over today's fission costs. Also widely agreed is that the critical-path-item for the fusion breeder is fusion development itself; however, development of fusion breeder specific items (blankets, fuel cycle) should be started now in order to have the fusion breeder by the time the rise in uranium prices forces other more costly choices.

  16. A polycaprolactone-tricalcium phosphate composite scaffold as an autograft-free spinal fusion cage in a sheep model.

    PubMed

    Li, Yi; Wu, Zhi-gang; Li, Xiao-kang; Guo, Zheng; Wu, Su-hua; Zhang, Yong-quan; Shi, Lei; Teoh, Swee-hin; Liu, Yu-chun; Zhang, Zhi-yong

    2014-07-01

    Titanium (Ti) based spinal fusion cages are frequently used in the clinics for the treatment of spinal degeneration and related diseases, however, their further clinical application is generally harassed by several drawbacks such as stress shielding, non-biodegradability and additional bone grafting procedure. Our earlier work has demonstrated the efficacy of a biodegradable macro-porous polycaprolactone-tricalcium phosphate (PCL-TCP) composite scaffold in promoting bony tissue ingrowth as well as its ability to sustain mechanical loads upon implantation into an orthotopic defect site. In this study, we investigated the use of PCL-TCP scaffold as an autograft-free spinal fusion cage in a preclinical sheep model over 12 months, and compared the fusion efficacy against Ti cages incorporated with autografts. Results showed that despite PCL-TCP scaffold as an autograft-free cage attaining a slower fusion rate at early stage (6 month), it achieved similar degree of spinal fusion efficacy as Ti cages aided with autograft at 12 month post-operation as evidenced by the radiographic and histological evaluation. PCL-TCP cages alone demonstrated better bone ingrowth with 2.6 fold higher bone/interspace ratio (B/I) and more homogeneous bone tissue distribution compared with that of the Ti cages (88.10  ±  3.63% vs. 33.74  ±  2.78%, p < 0.05) as seen from the histological and micro-CT analysis. Moreover, besides the bone tissue ingrowth, a quantitative approach was illustrated to accurately evaluate the osteointegration of fusion cage with surrounding bone tissue, and showed a 1.36 fold higher degree of osteointegration occurred in PCL-TCP cage group than Ti cage group (CS/PC: 79.31  ±  3.15% vs 58.44  ±  2.43%, p < 0.05). Furthermore, biomechanical analysis showed comparable mechanical strength of fused segments in both groups in terms of the range of motion and stiffness at 12 month (p > 0.05). The degradation profile of the PCL-TCP cages was noted to increase in tandem with new bone ingrowth into the pores, while maintaining good structural integrity necessary for supporting the spinal interbody segments. Therefore, with the better osteointegration, more bone tissue ingrowth as well as its favorable biodegradable and radiolucent properties, PCL-TCP cage has been demonstrated to be a promising candidate as an autograft-free fusion cage for clinical application. PMID:24743032

  17. Fusion for Neutrons as a Necessary Step to Commercial Fusion

    E-print Network

    1 Fusion for Neutrons as a Necessary Step to Commercial Fusion B. Kuteev Head of Fusion Reactor" MFERW, Princeton, NJ, USA, September 7-10, 2011 #12; Renewal of interest to fusion neutrons Growing interest to steady state operations, which are urgently needed for applications of fusion neutrons Several

  18. RESEARCH HIGHLIGHTS State of fusion

    E-print Network

    Loss, Daniel

    RESEARCH HIGHLIGHTS State of fusion In the 1950s,the promise of controlled nuclear fusion, although there is still some way to go to realize the dream,the latest status report on fusion research compiled by the International Fusion Research Council (Nucl. Fusion 45,A1­A28; 2005) provides good reason

  19. Fusion Energy Education

    NSDL National Science Digital Library

    The basics of fusion are deceptively simple: the process powers the sun and other stars, and it all takes place when atomic nuclei collide at high speed. But many questions remain. How can humans develop and exploit fusion energy? Is there a way to convert it more efficiently into useful mechanical, electrical, or thermal energy? This intriguing site, created by the Lawrence Livermore National Laboratory and the Princeton Plasma Physics Laboratory, presents an online fusion course designed to teach students and others about how fusion works and how it might be harnessed in the future. Visitors can try out The Guided Tour to get started, or they can click on one of the Main Topics. These include Energy Sources and Conversions, Two Key Fusion Reactions, and Creating the Conditions for Fusion. Each section contains graphics, explanatory text, and various diagrams. The site also includes charts which can be printed out for classroom use.

  20. Fusion facility siting considerations

    NASA Astrophysics Data System (ADS)

    Bussell, G. T.

    1985-02-01

    Inherent in the fusion program's transition from hydrogen devices to commercial power machines is a general increase in the size and scope of succeeding projects. This growth will lead to increased emphasis on safety, environmental impact, and the external effects of fusion in general, and of each new device in particular. An important consideration in this regard is site selection. Major siting issues that may affect the economics, safety, and environmental impact of fusion are examined.

  1. Multisensor Data Fusion

    Microsoft Academic Search

    Pramod K. Varshney

    2000-01-01

    Multisensor data fusion is a key enabling technology in which information from a number of sources is integrated to form a\\u000a unified picture [1]. This concept has been applied to numerous fields and new applications are being explored constantly. Even though most multisensor\\u000a data fusion applications have been developed relatively recently, the notion of data fusion has always been around.

  2. Biomechanical comparison of three stand-alone lumbar cages — a three-dimensional finite element analysis

    PubMed Central

    2013-01-01

    Background For anterior lumbar interbody fusion (ALIF), stand-alone cages can be supplemented with vertebral plate, locking screws, or threaded cylinder to avoid the use of posterior fixation. Intuitively, the plate, screw, and cylinder aim to be embedded into the vertebral bodies to effectively immobilize the cage itself. The kinematic and mechanical effects of these integrated components on the lumbar construct have not been extensively studied. A nonlinearly lumbar finite-element model was developed and validated to investigate the biomechanical differences between three stand-alone (Latero, SynFix, and Stabilis) and SynCage-Open plus transpedicular fixation. All four cages were instrumented at the L3-4 level. Methods The lumbar models were subjected to the follower load along the lumbar column and the moment at the lumbar top to produce flexion (FL), extension (EX), left/right lateral bending (LLB, RLB), and left/right axial rotation (LAR, RAR). A 10 Nm moment was applied to obtain the six physiological motions in all models. The comparison indices included disc range of motion (ROM), facet contact force, and stresses of the annulus and implants. Results At the surgical level, the SynCage-open model supplemented with transpedicular fixation decreased ROM (>76%) greatly; while the SynFix model decreased ROM 56-72%, the Latero model decreased ROM 36-91%, in all motions as compared with the INT model. However, the Stabilis model decreased ROM slightly in extension (11%), lateral bending (21%), and axial rotation (34%). At the adjacent levels, there were no obvious differences in ROM and annulus stress among all instrumented models. Conclusions ALIF instrumentation with the Latero or SynFix cage provides an acceptable stability for clinical use without the requirement of additional posterior fixation. However, the Stabilis cage is not favored in extension and lateral bending because of insufficient stabilization. PMID:24088294

  3. Fusion Plasma Performance Required for Fusion Power The performance achieved on MFE and IFE fusion experiments using DT fuel is compared with the fusion performance

    E-print Network

    Fusion Plasma Performance Required for Fusion Power The performance achieved on MFE and IFE fusion experiments using DT fuel is compared with the fusion performance required for a Fusion Power Plant. Const. Cost $B Date

  4. Neural net sensor fusion

    Microsoft Academic Search

    R. Y. Levine; T. S. Khuon

    1991-01-01

    A generic architecture for neural net multisensor data fusion is introduced and analyzed. The architecture consists of a set of independent sensor neural nets, one for each sensor, coupled to a fusion net. Each sensor is trained (from a representative data set of the particular sensor) to map to a hypothesis space output. The decision outputs from the sensor nets

  5. Fusion welding process

    Microsoft Academic Search

    E. D. Jones; M. A. Mcbride; K. C. Thomas

    1983-01-01

    A process for the fusion welding of nickel alloy steel members wherein a ferrite containing pellet is inserted into a cavity in one member and melted by a welding torch. The resulting weld nugget, a fusion of the nickel containing alloy from the members to be welded and the pellet, has a composition which is sufficiently low in nickel content

  6. Coatings for laser fusion

    SciTech Connect

    Lowdermilk, W.H.

    1981-12-18

    Optical coatings are used in lasers systems for fusion research to control beam propagation and reduce surface reflection losses. The performance of coatings is important in the design, reliability, energy output, and cost of the laser systems. Significant developments in coating technology are required for future lasers for fusion research and eventual power reactors.

  7. Spherical torus fusion reactor

    Microsoft Academic Search

    Martin Peng; Y. K. M

    1985-01-01

    The object of this invention is to provide a compact torus fusion reactor with dramatic simplification of plasma confinement design. Another object of this invention is to provide a compact torus fusion reactor with low magnetic field and small aspect ratio stable plasma confinement. In accordance with the principles of this invention there is provided a compact toroidal-type plasma confinement

  8. Aspects of Phonological Fusion

    ERIC Educational Resources Information Center

    Cutting, James E.

    1975-01-01

    Phonological fusion occurs when the phonemes of two different speech stimuli are combined into a new percept that is longer and linguistically more complex than either of the two inputs. The present article is an investigation of the conditions necessary and sufficient for fusion to occur. (Editor/RK)

  9. Robotics and local fusion

    Microsoft Academic Search

    Philip J. Emmerman

    2005-01-01

    Teams of robots or mixed teams of warfighters and robots on reconnaissance and other missions can benefit greatly from a local fusion station. A local fusion station is defined here as a small mobile processor with interfaces to enable the ingestion of multiple heterogeneous sensor data and information streams, including blue force tracking data. These data streams are fused and

  10. Controlled Nuclear Fusion.

    ERIC Educational Resources Information Center

    Glasstone, Samuel

    This publication is one of a series of information booklets for the general public published by The United States Atomic Energy Commission. Among the topics discussed are: Importance of Fusion Energy; Conditions for Nuclear Fusion; Thermonuclear Reactions in Plasmas; Plasma Confinement by Magnetic Fields; Experiments With Plasmas; High-Temperature…

  11. Total wrist fusion

    Microsoft Academic Search

    J. Field; T. J. Herbert; R. Prosser

    1996-01-01

    Twenty cases of total wrist fusion, performed for post-traumatic conditions, were reviewed objectively, subjectively and radiologically. All patients were satisfied with the position of the fused wrist and had good pain relief. All patients would have had the procedure sooner, having had an average of three operations on the wrist before the fusion. There was a high complication rate (45%),

  12. Muon-catalyzed fusion

    Microsoft Academic Search

    W. H. Breunlich; P. Kammel; J. S. Cohen; M. Leon

    1989-01-01

    Great progress achieved in muon-catalyzed fusion research in the past decade now makes it possible to review careful quantitative calculations and measurements. The major experimental surprises have doubled the fusion yields, but direct energy production would appear to be excluded without a significant breakthrough.(AIP)

  13. Muon catalysed fusion

    Microsoft Academic Search

    L. I. Ponomarev

    1990-01-01

    A decade ago it was established that one muon in a deuterium-tritium mixture can catalyse more than 100 nuclear fusion reactions and that this phenomenon could be used for the production of nuclear fuel and energy. This review presents the state of the art of muon catalysed fusion studies and its place among alternative methods of nuclear breeding. The main

  14. Inertial fusion reactors (review)

    Microsoft Academic Search

    A V Kalinin

    1984-01-01

    The current status of the work on engineering problems of inertial fusion is reviewed. The state of laboratory physics research, aspects of driver choice, and pellet designs are discussed. Particular attention is paid to the development of inertial fusion reactors and their energy applications. It is shown that lasers with output energies in the 0.5-5.0 MJ range must be acknowledged

  15. Presented by Information Fusion

    E-print Network

    Information Fusion at ORNL · ORNL Instrumental in formulating and fostering this multi-disciplinary area by ASCR Statistics Program ­ Cyber-physical networks ­ ASCR Applied Math Program 2009 - present · Foundational work at ORNL: ­ Showed tractability of generic information fusion problem using measurements

  16. Fusion excitation function revisited

    E-print Network

    Ph. Eudes; Z. Basrak; F. Sébille; V. de la Mota; G. Royer; M. Zori?

    2012-09-28

    We report on a comprehensive systematics of fusion-evaporation and/or fusion-fission cross sections for a very large variety of systems over an energy range 4-155 A.MeV. Scaled by the reaction cross sections, fusion cross sections do not show a universal behavior valid for all systems although a high degree of correlation is present when data are ordered by the system mass asymmetry.For the rather light and close to mass-symmetric systems the main characteristics of the complete and incomplete fusion excitation functions can be precisely determined. Despite an evident lack of data above 15A.MeV for all heavy systems the available data suggests that geometrical effects could explain the persistence of incomplete fusion at incident energies as high as 155A.MeV.

  17. Robotics and local fusion

    NASA Astrophysics Data System (ADS)

    Emmerman, Philip J.

    2005-05-01

    Teams of robots or mixed teams of warfighters and robots on reconnaissance and other missions can benefit greatly from a local fusion station. A local fusion station is defined here as a small mobile processor with interfaces to enable the ingestion of multiple heterogeneous sensor data and information streams, including blue force tracking data. These data streams are fused and integrated with contextual information (terrain features, weather, maps, dynamic background features, etc.), and displayed or processed to provide real time situational awareness to the robot controller or to the robots themselves. These blue and red force fusion applications remove redundancies, lessen ambiguities, correlate, aggregate, and integrate sensor information with context such as high resolution terrain. Applications such as safety, team behavior, asset control, training, pattern analysis, etc. can be generated or enhanced by these fusion stations. This local fusion station should also enable the interaction between these local units and a global information world.

  18. Thermal Resonance Fusion

    E-print Network

    Bao-Guo Dong

    2015-07-07

    We first show a possible mechanism to create a new type of nuclear fusion, thermal resonance fusion, i.e. low energy nuclear fusion with thermal resonance of light nuclei or atoms, such as deuterium or tritium. The fusion of two light nuclei has to overcome the Coulomb barrier between these two nuclei to reach up to the interacting region of nuclear force. We found nuclear fusion could be realized with thermal vibrations of crystal lattice atoms coupling with light atoms at low energy by resonance to overcome this Coulomb barrier. Thermal resonances combining with tunnel effects can greatly enhance the probability of the deuterium fusion to the detectable level. Our low energy nuclear fusion mechanism research - thermal resonance fusion mechanism results demonstrate how these light nuclei or atoms, such as deuterium, can be fused in the crystal of metal, such as Ni or alloy, with synthetic thermal vibrations and resonances at different modes and energies experimentally. The probability of tunnel effect at different resonance energy given by the WKB method is shown that indicates the thermal resonance fusion mode, especially combined with the tunnel effect, is possible and feasible. But the penetrating probability decreases very sharply when the input resonance energy decreases less than 3 keV, so for thermal resonance fusion, the key point is to increase the resonance peak or make the resonance sharp enough to the acceptable energy level by the suitable compound catalysts, and it is better to reach up more than 3 keV to make the penetrating probability larger than 10^{-10}.

  19. Alperin's Fusion Theorem and Fusion Systems David A. Craven

    E-print Network

    Craven, David A.

    Alperin's Fusion Theorem and Fusion Systems David A. Craven September 2010 Abstract This short note provides a new and straightforward proof of the original fusion theorem of Alperin, then considers so-called domestic intersections, which are special types of tame intersections that should play a role in fusion

  20. Up-Fusion: An Evolving Multimedia Decision Fusion Xiangyu Wang

    E-print Network

    Rui, Yong

    Up-Fusion: An Evolving Multimedia Decision Fusion Method Xiangyu Wang National Univ. of Singapore multimedia's nature of hav- ing multiple information sources, fusion methods are criti- cal for its data analysis and understanding. However, most of the traditional fusion methods are static with respect to time

  1. Fusion Ignition Research Experiment Highlights

    E-print Network

    Fusion Ignition Research Experiment Highlights FY 2004 Fusion Ignition Research Experiment #12;Need is critically needed to advance fusion science," and recommended that: "The United States should participate in the U.S. fusion program. The scientific and technological case for adding a burning plasma experiment

  2. Network Fusion Pascal Fradet1

    E-print Network

    Paris-Sud XI, Université de

    Network Fusion Pascal Fradet1 and St´ephane Hong Tuan Ha2 1 INRIA Rh^one-Alpes 655, av. de l composition method which strives to reconcile modularity and efficiency. Our technique, network fusion fusion. Fusion allows to replace internal commu- nications by assignments and alleviates most time

  3. Fusion research at ORNL

    NASA Astrophysics Data System (ADS)

    1982-03-01

    The ORNL fusion program which includes the experimental and theoretical study of two different classes of magnetic confinement schemes is outlined. The study includes: systems with helical magnetic fields, such as the Tokamak and stellarator, and the ELMO Bumpy Torus (EBT) class of toroidally linked mirror systems; the development of technologies, including superconducting magnets, neutral atomic beam and radio frequency (RF) heating systems, fueling systems, materials, and diagnostics; the development of the environment impact of magnetic fusion; and the design of advanced demonstration fusion devices.

  4. Fusion for Space Propulsion

    NASA Technical Reports Server (NTRS)

    Thio, Y. C. Francis; Schafer, Charles (Technical Monitor)

    2001-01-01

    There is little doubt that humans will attempt to explore and develop the solar system in this century. A large amount of energy will be required for accomplishing this. The need for fusion propulsion is discussed. For a propulsion system, there are three important thermodynamical attributes: (1) The absolute amount of energy available, (2) the propellant exhaust velocity, and (3) the jet power per unit mass of the propulsion system (specific power). For human exploration and development of the solar system, propellant exhaust velocity in excess of 100 km/s and specific power in excess of 10 kW/kg are required. Chemical combustion can produce exhaust velocity up to about 5 km/s. Nuclear fission processes typically result in producing energy in the form of heat that needs to be manipulated at temperatures limited by materials to about 2,800 K. Using the energy to heat a hydrogen propellant increases the exhaust velocity by only a factor of about two. Alternatively the energy can be converted into electricity which is then used to accelerate particles to high exhaust velocity. The necessary power conversion and conditioning equipment, however, increases the mass of the propulsion system for the same jet power by more than two orders of magnitude over chemical system, thus greatly limits the thrust-to-weight ratio attainable. The principal advantage of the fission process is that its development is relatively mature and is available right now. If fusion can be developed, fusion appears to have the best of all worlds in terms of propulsion - it can provide the absolute amount, the propellant exhaust velocity, and the high specific jet power. An intermediate step towards pure fusion propulsion is a bimodal system in which a fission reactor is used to provide some of the energy to drive a fusion propulsion unit. The technical issues related to fusion for space propulsion are discussed. The technical priorities for developing and applying fusion for propulsion are somewhat different from those for terrestrial electrical power generation. Thus fusion schemes that are initially attractive for electrical power generation might not necessarily be attractive also for propulsion and vice versa, though the underlying fusion science and engineering enjoy much overlap. Parallel efforts to develop these qualitatively differently fusion schemes for the two applications could benefit greatly from each other due to the synergy in the underlying physics and engineering. Pulsed approaches to fusion have not been explored to the same degree as steady-state or long-pulse approaches to fusion in the fusion power research program. The concerns early on were several. One was that the pulsed power components might not have the service lifetimes meeting the requirements of a practical power generating plant. Another was that, for many pulsed fusion schemes, it was not clear whether the destruction of hardware per pulse could be minimized or eliminated or recycled to such an extent as to make economical electrical power generation feasible, Significant development of the underlying pulsed power component technologies have occurred in the last two decades because of defense and other energy requirements. The state of development of the pulsed power technologies are sufficiently advanced now to make it compelling to visit or re-visit pulsed fusion approaches for application to propulsion where the cost of energy is not so demanding a factor as in the case of terrestrial power application. For propulsion application, the overall mass of the fusion system is the critical factor. Producing fusion reactions require extreme states of matter. Conceptually, these extreme states of matter are more readily realizable in the pulsed states, at least within appropriate bounds, than in the steady states. Significant saving in system mass may result in such systems. Magnetic fields are effective in confining plasma energy, whereas inertial compression is an effective way of heating and containing the plasma. Intensive research in developing magnetic energy containme

  5. Fusion-breeder program

    SciTech Connect

    Moir, R.W.

    1982-11-19

    The various approaches to a combined fusion-fission reactor for the purpose of breeding /sup 239/Pu and /sup 233/U are described. Design aspects and cost estimates for fuel production and electricity generation are discussed. (MOW)

  6. Fusion: The Hydrogen Bomb

    NSDL National Science Digital Library

    2004-02-20

    Just after World War II, nuclear scientists turned their attention from fission to fusion. This video segment adapted from AMERICAN EXPERIENCE looks at the beginnings of thermonuclear power generation.

  7. Fusion Energy Sciences

    NSDL National Science Digital Library

    1969-12-31

    As part of the US Department of Energy, the Office of Science contains the Fusion Energy Sciences program, whose mission is to advance plasma science and fusion science technology. The program "supports research to understand the physics of plasmas; to identify and explore innovative and cost-effective development paths to fusion energy; and as a partner in international efforts, to advance the science and technology of energy-producing plasmas." Visitors to the Fusion Energy Sciences Web site will find current news related to the program, a program highlights document, several informative published papers, additional links, and more. If you're interested in energy, physics, or other related sciences, you'll definitely enjoy learning about the cutting edge science being undertaken within the department.

  8. On cold fusion

    Microsoft Academic Search

    Spinrad

    1990-01-01

    This paper argues that a high negative voltage on a metal into which deuterium is soaked might enhance fusion reactions. The author discusses how this may have been the way Fleischmann and Pons achieved their results.

  9. Spectral Label Fusion

    E-print Network

    Wachinger, Christian

    We present a new segmentation approach that combines the strengths of label fusion and spectral clustering. The result is an atlas-based segmentation method guided by contour and texture cues in the test image. This offers ...

  10. Cold nuclear fusion

    SciTech Connect

    Tsyganov, E. N., E-mail: edward.tsyganov@utsouthwestern.edu [University of Texas Southwestern Medical Center at Dallas (United States)

    2012-02-15

    Recent accelerator experiments on fusion of various elements have clearly demonstrated that the effective cross-sections of these reactions depend on what material the target particle is placed in. In these experiments, there was a significant increase in the probability of interaction when target nuclei are imbedded in a conducting crystal or are a part of it. These experiments open a new perspective on the problem of so-called cold nuclear fusion.

  11. Building fusion systems

    Microsoft Academic Search

    E. Shahbazian

    2002-01-01

    Information and data fusion is a discipline that provides the methods and techniques to build observe-orient-decide-act (OODA) capabilities for various applications. There are many ways in which these methods and techniques can be chosen to provide capabilities in each phase of the OODA decision-making cycle, and there are different fusion architectures, i.e., ways these methods and techniques can be applied,

  12. Fusion product spectra

    SciTech Connect

    Talley, T.L.; Hale, G.M.

    1988-01-01

    Accurate fusion product data is required for most fusion plasma simulations. The energy broadening of reaction products is demonstrated to be more complicated than the usual Gaussian broadening. The accurate integrals are performed to obtain , , and for all binary reactions in the four- and five-nucleon systems. Reaction cross sections were developed using R-Matrix models that include most recent measurements.

  13. Still Flying Fusion Edition

    E-print Network

    2013-11-27

    . ; The Fox Television Broadcasting Company ; 20th Century Fox Ltd. ; Fox Home Entertainment or Universal Pictures All rights are reserved and owned by the copyright holders as appropriate. Welcome to this very special Fusion Edition of Still.... This abridged edition is available only at Fusion, Issue Two will be available soon, complete with an Adam Baldwin interview! If you wish to subscribe (for free) please email stillflying@bitwiser.com with the subject heading "Subscribe" and you...

  14. Fusion ignition research experiment

    SciTech Connect

    Dale Meade

    2000-07-18

    Understanding the properties of high gain (alpha-dominated) fusion plasmas in an advanced toroidal configuration is the largest remaining open issue that must be addressed to provide the scientific foundation for an attractive magnetic fusion reactor. The critical parts of this science can be obtained in a compact high field tokamak which is also likely to provide the fastest and least expensive path to understanding alpha-dominated plasmas in advanced toroidal systems.

  15. Harms titanium mesh cage fracture

    Microsoft Academic Search

    Zdenek Klezl; Carlos A. Bagley; Markus J. Bookland; Jean-Paul Wolinsky; Zdenek Rezek; Ziya L. Gokaslan

    2007-01-01

    Interbody fusion has become a mainstay of surgical management for lumbar fractures, tumors, spondylosis, spondylolisthesis\\u000a and deformities. Over the years, it has undergone a number of metamorphoses, as novel instrumentation and approaches have\\u000a arisen to reduce complications and enhance outcomes. Interbody fusion procedures are common and successful, complications\\u000a are rare and most often do not involve the interbody device itself.

  16. ITER Fusion Energy

    ScienceCinema

    Dr. Norbert Holtkamp

    2010-01-08

    ITER (in Latin ?the way?) is designed to demonstrate the scientific and technological feasibility of fusion energy. Fusion is the process by which two light atomic nuclei combine to form a heavier over one and thus release energy. In the fusion process two isotopes of hydrogen ? deuterium and tritium ? fuse together to form a helium atom and a neutron. Thus fusion could provide large scale energy production without greenhouse effects; essentially limitless fuel would be available all over the world. The principal goals of ITER are to generate 500 megawatts of fusion power for periods of 300 to 500 seconds with a fusion power multiplication factor, Q, of at least 10. Q ? 10 (input power 50 MW / output power 500 MW). The ITER Organization was officially established in Cadarache, France, on 24 October 2007. The seven members engaged in the project ? China, the European Union, India, Japan, Korea, Russia and the United States ? represent more than half the world?s population. The costs for ITER are shared by the seven members. The cost for the construction will be approximately 5.5 billion Euros, a similar amount is foreseen for the twenty-year phase of operation and the subsequent decommissioning.

  17. Magnetized Target Fusion

    NASA Technical Reports Server (NTRS)

    Griffin, Steven T.

    2002-01-01

    Magnetized target fusion (MTF) is under consideration as a means of building a low mass, high specific impulse, and high thrust propulsion system for interplanetary travel. This unique combination is the result of the generation of a high temperature plasma by the nuclear fusion process. This plasma can then be deflected by magnetic fields to provide thrust. Fusion is initiated by a small traction of the energy generated in the magnetic coils due to the plasma's compression of the magnetic field. The power gain from a fusion reaction is such that inefficiencies due to thermal neutrons and coil losses can be overcome. Since the fusion reaction products are directly used for propulsion and the power to initiate the reaction is directly obtained from the thrust generation, no massive power supply for energy conversion is required. The result should be a low engine mass, high specific impulse and high thrust system. The key is to successfully initiate fusion as a proof-of-principle for this application. Currently MSFC is implementing MTF proof-of-principle experiments. This involves many technical details and ancillary investigations. Of these, selected pertinent issues include the properties, orientation and timing of the plasma guns and the convergence and interface development of the "pusher" plasma. Computer simulations of the target plasma's behavior under compression and the convergence and mixing of the gun plasma are under investigation. This work is to focus on the gun characterization and development as it relates to plasma initiation and repeatability.

  18. Membrane Fusion Triggering

    PubMed Central

    Navaratnarajah, Chanakha K.; Negi, Surendra; Braun, Werner; Cattaneo, Roberto

    2012-01-01

    The measles virus (MV) fusion apparatus consists of a fusion protein and an attachment protein named hemagglutinin (H). After receptor-binding through its cuboidal head, the H-protein transmits the fusion-triggering signal through its stalk to the fusion protein. However, the structural basis of signal transmission is unclear because only structures of H-heads without their stalk have been solved. On the other hand, the entire ectodomain structure of the hemagglutinin-neuraminidase protein of another Paramyxovirus revealed a four-helix bundle stalk. To probe the structure of the 95-residue MV H-stalk we individually substituted head-proximal residues (positions 103–153) with cysteine, and biochemically and functionally characterized the resultant proteins. Our results indicate that most residues in the central segment (positions 103–117) can be cross-linked by engineered disulfide bonds, and thus may be engaged in a tetrameric structure. While covalent tetramerization disrupts fusion triggering function, disulfide bond reduction restores it in most positions except Asp-113. The next stalk segment (residues 123–138) also has high propensity to form covalent tetramers, but since these cross-links have little or no effect on function, it can conduct the fusion-triggering signal while remaining in a stabilized tetrameric configuration. This segment may act as a spacer, maintaining H-heads at an optimal height. Finally, the head-proximal segment (residues 139–154) has very limited propensity to trap tetramers, suggesting bifurcation into two flexible linkers clamped by inter-subunit covalent links formed by natural Cys-139 and Cys-154. We discuss the modular structure of the MV H-stalk in the context of membrane fusion triggering and cell entry by Paramyxoviruses. PMID:23007387

  19. Fusion Power Associates -2013 Annual Meeting 1 General Fusion

    E-print Network

    Annual Meeting 2 The MTF "Solution" Recognized as: · Low cost · Practical Fixed: · First wall problem - 2013 Annual Meeting 3 General Fusion's Acoustically Driven MTF #12;Fusion Power Associates - 2013

  20. Challenges of nuclear fusion

    SciTech Connect

    Kunkel, W.B.

    1987-05-01

    After 30 years of research and development in many countries, the magnetic confinement fusion experiments finally seem to be getting close to the original first goal: the point of ''scientific break-even.'' Plans are being made for a generation of experiments and tests with actual controlled thermonuclear fusion conditions. Therefore, engineers and material scientists are hard at work to develop the required technology. In this paper the principal elements of a generic fusion reactor are described briefly to introduce the reader to the nature of the problems at hand. The main portion of the presentation summarizes the recent advances made in this field and discusses the major issues that still need to be addressed in regard to materials and technology for fusion power. Specific examples are the problems of the first wall and other components that come into direct contact with the plasma, where both lifetime and plasma contamination are matters of concern. Equally challenging are the demands on structural materials and on the magnetic-field coils, particularly in connection with the neutron-radiation environment of fusion reactors. Finally, the role of ceramics must be considered, both for insulators and for fuel breeding purposes. It is evident that we still have a formidable task before us, but at this point none of the problems seem to be insoluble. 17 refs., 3 figs.

  1. Realization of Fusion Energy: An alternative fusion roadmap

    E-print Network

    Realization of Fusion Energy: An alternative fusion roadmap Farrokh Najmabadi Professor of Electrical & Computer Engineering Director, Center for Energy Research UC San Diego International Fusion Road of emerging nations, energy use is expected to grow ~ 4 fold in this century (average 1.6% annual growth rate

  2. Multisensor data fusion algorithm development

    SciTech Connect

    Yocky, D.A.; Chadwick, M.D.; Goudy, S.P.; Johnson, D.K.

    1995-12-01

    This report presents a two-year LDRD research effort into multisensor data fusion. We approached the problem by addressing the available types of data, preprocessing that data, and developing fusion algorithms using that data. The report reflects these three distinct areas. First, the possible data sets for fusion are identified. Second, automated registration techniques for imagery data are analyzed. Third, two fusion techniques are presented. The first fusion algorithm is based on the two-dimensional discrete wavelet transform. Using test images, the wavelet algorithm is compared against intensity modulation and intensity-hue-saturation image fusion algorithms that are available in commercial software. The wavelet approach outperforms the other two fusion techniques by preserving spectral/spatial information more precisely. The wavelet fusion algorithm was also applied to Landsat Thematic Mapper and SPOT panchromatic imagery data. The second algorithm is based on a linear-regression technique. We analyzed the technique using the same Landsat and SPOT data.

  3. Fusion Categories and Homotopy Theory

    E-print Network

    Etingof, Pavel I.

    We apply the yoga of classical homotopy theory to classification problems of G-extensions of fusion and braided fusion categories, where G is a finite group. Namely, we reduce such problems to classification (up to homotopy) ...

  4. Fusion reactors as a future energy source

    Microsoft Academic Search

    W. Seifritz

    1975-01-01

    A detailed update of fusion research concepts is given. Discussions are given for the following areas: (1) the magnetic confinement principle, (2) UWMAK I: conceptual design for a fusion reactor, (3) the inertial confinement principle, (4) the laser fusion power plant, (5) electron-induced fusion, (6) the long-term development potential of fusion reactors, (7) the symbiosis between fusion and fission reactors,

  5. CRYOGENICS FOR FUSION

    SciTech Connect

    Dauguet, P.; Bonneton, M.; Fauve, E.; Bernhardt, J. M.; Beauvisage, J.; Andrieu, F. [Air Liquide Advanced Technology Division BP15, ZI Les Engenieres, 38360 Sassenage (France); Gistau-Baguer, G. M.; Boissin, J. C. [Consultants, Grenoble (France)

    2008-03-16

    Fusion of Hydrogen to produce energy is one of the technologies under study to meet the mankind raising need in energy and as a substitute to fossil fuels for the future. This technology is under investigation for more than 30 years already, with, for example, the former construction of the experimental reactors Tore Supra, DIII-D and JET. With the construction of ITER to start, the next step to 'fusion for energy' will be done. In these projects, an extensive use of cryogenic systems is requested. Air Liquide has been involved as cryogenic partner in most of former and presently constructed fusion reactors. In the present paper, a review of the cryogenic systems we delivered to Tore Supra, JET, IPR and KSTAR will be presented.

  6. Simulation of Fusion Plasmas

    ScienceCinema

    Chris Holland

    2010-01-08

    The upcoming ITER experiment (www.iter.org) represents the next major milestone in realizing the promise of using nuclear fusion as a commercial energy source, by moving into the ?burning plasma? regime where the dominant heat source is the internal fusion reactions. As part of its support for the ITER mission, the US fusion community is actively developing validated predictive models of the behavior of magnetically confined plasmas. In this talk, I will describe how the plasma community is using the latest high performance computing facilities to develop and refine our models of the nonlinear, multiscale plasma dynamics, and how recent advances in experimental diagnostics are allowing us to directly test and validate these models at an unprecedented level.

  7. Spherical torus fusion reactor

    DOEpatents

    Peng, Yueng-Kay M. (Oak Ridge, TN)

    1989-01-01

    A fusion reactor is provided having a near spherical-shaped plasma with a modest central opening through which straight segments of toroidal field coils extend that carry electrical current for generating a toroidal magnet plasma confinement fields. By retaining only the indispensable components inboard of the plasma torus, principally the cooled toroidal field conductors and in some cases a vacuum containment vessel wall, the fusion reactor features an exceptionally small aspect ratio (typically about 1.5), a naturally elongated plasma cross section without extensive field shaping, requires low strength magnetic containment fields, small size and high beta. These features combine to produce a spherical torus plasma in a unique physics regime which permits compact fusion at low field and modest cost.

  8. Ceramics for fusion devices

    SciTech Connect

    Clinard, F.W. Jr.

    1984-01-01

    Ceramics are required for a number of applications in fusion devices, among the most critical of which are magnetic coil insulators, windows for RF heating systems, and structural uses. Radiation effects dominate consideration of candidate materials, although good pre-irradiation properties are a requisite. Materials and components can be optimized by careful control of chemical and microstructural content, and application of brittle material design and testing techniques. Future directions for research and development should include further extension of the data base in the areas of electrical, structural, and thermal properties; establishment of a fission neutron/fusion neutron correlation including transmutation gas effects; and development of new materials tailored to meet the specific needs of fusion reactors.

  9. Intense fusion neutron sources

    SciTech Connect

    Kuteev, B. V. [Russian Research Centre Kurchatov Institute (Russian Federation); Goncharov, P. R.; Sergeev, V. Yu. [St. Petersburg State Polytechnic University (Russian Federation); Khripunov, V. I. [Russian Research Centre Kurchatov Institute (Russian Federation)

    2010-04-15

    The review describes physical principles underlying efficient production of free neutrons, up-to-date possibilities and prospects of creating fission and fusion neutron sources with intensities of 10{sup 15}-10{sup 21} neutrons/s, and schemes of production and application of neutrons in fusion-fission hybrid systems. The physical processes and parameters of high-temperature plasmas are considered at which optimal conditions for producing the largest number of fusion neutrons in systems with magnetic and inertial plasma confinement are achieved. The proposed plasma methods for neutron production are compared with other methods based on fusion reactions in nonplasma media, fission reactions, spallation, and muon catalysis. At present, intense neutron fluxes are mainly used in nanotechnology, biotechnology, material science, and military and fundamental research. In the near future (10-20 years), it will be possible to apply high-power neutron sources in fusion-fission hybrid systems for producing hydrogen, electric power, and technological heat, as well as for manufacturing synthetic nuclear fuel and closing the nuclear fuel cycle. Neutron sources with intensities approaching 10{sup 20} neutrons/s may radically change the structure of power industry and considerably influence the fundamental and applied science and innovation technologies. Along with utilizing the energy produced in fusion reactions, the achievement of such high neutron intensities may stimulate wide application of subcritical fast nuclear reactors controlled by neutron sources. Superpower neutron sources will allow one to solve many problems of neutron diagnostics, monitor nano-and biological objects, and carry out radiation testing and modification of volumetric properties of materials at the industrial level. Such sources will considerably (up to 100 times) improve the accuracy of neutron physics experiments and will provide a better understanding of the structure of matter, including that of the neutron itself.

  10. Atomic data for fusion

    SciTech Connect

    Hunter, H.T.; Kirkpatrick, M.I.; Alvarez, I.; Cisneros, C.; Phaneuf, R.A. (eds.) [eds.; Barnett, C.F.

    1990-07-01

    This report provides a handbook of recommended cross-section and rate-coefficient data for inelastic collisions between hydrogen, helium and lithium atoms, molecules and ions, and encompasses more than 400 different reactions of primary interest in fusion research. Published experimental and theoretical data have been collected and evaluated, and the recommended data are presented in tabular, graphical and parametrized form. Processes include excitation and spectral line emission, charge exchange, ionization, stripping, dissociation and particle interchange reactions. The range of collision energies is appropriate to applications in fusion-energy research.

  11. Data fusion of multisensor data

    Microsoft Academic Search

    Sheng Tang

    2000-01-01

    The problem of data fusion of multisensor data for multitarget tracking is considered. A hierarchical fusion system is presented for fusion of numerical data from multiple local radar stations, and a fuzzy clustering technique is introduced. Simulation results are presented for a scenario having three local radar stations and three targets with trajectories containing some type of acceleration and varying

  12. Prospects for economic fusion electricity

    Microsoft Academic Search

    I. Cook; R. L. Miller; D. J. Ward

    2002-01-01

    Extensive studies of fusion economics have been performed in the last decade within the European Union and the United States. Over the same period major advances have been made in the physics and technology of fusion. This paper summarizes the prospects for fusion making an economically attractive contribution to the future energy mix. With modest physics optimization and anticipated near-term

  13. The Fusion Machine (extended abstract)

    E-print Network

    Gardner, Philippa

    The Fusion Machine (extended abstract) Philippa Gardner Cosimo Laneve Lucian Wischik March 27, 2002. In particular, we describe a dis- tributed abstract machine called the fusion machine. In it, only channels exist at runtime. It uses a form of concurrent constraints called fusions--equations on channel names

  14. Environmental aspects of fusion reactors

    Microsoft Academic Search

    F. E. Coffman; J. M. Williams

    1975-01-01

    Potential environmental impacts of commercial fusion reactors are discussed and compared with those of fission reactors. It is shown that the environmental impact of fusion reactors will be quite small, with the main contribution coming from thermal discharges. Some attractive safety and environmental characteristics of fusion reactors are described, including an effectively infinite low-cost fuel supply, their inherent incapacity for

  15. Human-Centered Fusion Framework

    SciTech Connect

    Posse, Christian; White, Amanda M.; Beagley, Nathaniel

    2007-05-16

    In recent years the benefits of fusing signatures extracted from large amounts of distributed and/or heterogeneous data sources have been largely documented in various problems ranging from biological protein function prediction to cyberspace monitoring. In spite of significant progress in information fusion research, there is still no formal theoretical framework for defining various types of information fusion systems, defining and analyzing relations among such types, and designing information fusion systems using a formal method approach. Consequently, fusion systems are often poorly understood, are less than optimal, and/or do not suit user needs. To start addressing these issues, we outline a formal humancentered fusion framework for reasoning about fusion strategies. Our approach relies on a new taxonomy for fusion strategies, an alternative definition of information fusion in terms of parameterized paths in signature related spaces, an algorithmic formalization of fusion strategies and a library of numeric and dynamic visual tools measuring the impact as well as the impact behavior of fusion strategies. Using a real case of intelligence analysis we demonstrate that the proposed framework enables end users to rapidly 1) develop and implement alternative fusion strategies, 2) understand the impact of each strategy, 3) compare the various strategies, and 4) perform the above steps without having to know the mathematical foundations of the framework. We also demonstrate that the human impact on a fusion system is critical in the sense that small changes in strategies do not necessarily correspond to small changes in results.

  16. Third Edition, Gene Fusion System

    E-print Network

    Lai, Zhi-Chun

    Cleavage ............................. 19 Detection of GST Fusion Proteins .... 20 17. Measurement of GSTThird Edition, Revision 2 18-1123-20 GST Gene Fusion System #12;PROTEIN DATA BANK ADVISORY NOTICE. Screening pGEX Vectors with PCR ..... 10 Purification of GST Fusion Proteins.. 11 8. Preparation

  17. Tutorial 14: multisensor data fusion

    Microsoft Academic Search

    David Macii; Andrea Boni; Mariolino De Cecco; Dario Petri

    2008-01-01

    Multisensor data fusion is an emerging discipline. The rapid evolution of high-performance, inexpensive, and low-power computing components for pervasive systems, such as wireless sensor networks, will enable the development of complex sensor fusion applications. The idea underlying data fusion is to combine information collected by different sensors, to make inferences at different levels of abstraction about an entity or a

  18. Grand challenges of information fusion

    Microsoft Academic Search

    Dale A. Lambert

    2003-01-01

    The paper presents the Future Operations Centre Analysis Laboratory data34sion system, composed of both people and machines, A WDL revision of the JDL model of data fusion is proposed for this data fusion system. This leads to the identification of a number of grand challenges of information fusion. The Future Operations Centre Analysis Laboratory programme approach to these grand challenges

  19. Fusion reactor radioactive waste management

    Microsoft Academic Search

    J. D. Kaser; A. K. Postma; D. J. Bradley

    1976-01-01

    Quantities and compositions of non-tritium radioactive waste are estimated for some current conceptual fusion reactor designs, and disposal of large amounts of radioactive waste appears necessary. Although the initial radioactivity of fusion reactor and fission reactor wastes are comparable, the radionuclides in fusion reactor wastes are less hazardous and have shorter half-lives. Areas requiring further research are discussed.

  20. Control of Fusion and Solubility in Fusion Systems David A. Craven

    E-print Network

    Craven, David A.

    Control of Fusion and Solubility in Fusion Systems David A. Craven March 2009 Abstract In this article, we consider control of fusion, quotients, and p-soluble fusion systems. For control of fusion, we for fusion systems. We move on to p-soluble fusion systems, and prove that they are constrained, allowing us

  1. Migration of a broken scalpel into the heart after spine surgery.

    PubMed

    De Praetere, Herbert; Vanden Eycken, Caroline; Meuris, Bart; Herijgers, Paul

    2014-04-01

    Iatrogenic vascular problems during posterior lumbar interbody fusion are a rare entity. Migration of a broken scalpel towards the heart has, to our knowledge, never been reported. We present the successful surgical retrieval of a broken scalpel from the heart after posterior lumbar interbody fusion without the use of a cardiopulmonary bypass. PMID:24435837

  2. NDT Data Fusion

    Microsoft Academic Search

    Alistair McNab

    1997-01-01

    Data fusion is a topic which is currently causing much interest. In NDT, the combining of data from a number of independent sources related to the same test component can provide a more complete and accurate assessment of any flaws present. Ultrasonic testing, radiographic and eddy current inspection, as well as other methods, can provide the required diversity of information.

  3. Information Fusion user name

    E-print Network

    Hefei Institute of Intelligent Machines

    nmlkj by editor Browse for journals Search our full text articles gfedcb Search only in Computer Science policy | contact us ?copyright Elsevier Page 1 of 1Elsevier Author Gateway 5/18/2003http://authors.elsevier.com/Journal Powered by Search An International Journal on Multi-Sensor, Multi-Source Information Fusion Guide

  4. Materials for fusion reactors

    Microsoft Academic Search

    1978-01-01

    Material problems for fusion reactor consist of finding materials to be used for the first wall, limiters, electrical insulation, neutron moderators, shielding, and component for superconducting magnets. Materials being considered for the first wall include austenitic stainless steel, nickel, titanium, refractory metals and aluminium alloys. TiC, graphite, copper, and refractory metals are being evaluated for limiters which are used to

  5. Advanced spheromak fusion reactor

    Microsoft Academic Search

    T. K. Fowler; E. B. Hooper

    1996-01-01

    The spheromak has no toroidal magnetic field coils or other structure along its geometric axis, and is thus more attractive than the leading magnetic fusion reactor concept, the tokamak. As a consequence of this and other attributes, the spheromak reactor may be compact and produce a power density sufficiently high to warrant consideration of a liquid `blanket` that breeds tritium,

  6. Spherical torus fusion reactor

    Microsoft Academic Search

    Peng; Yueng-Kay M

    1989-01-01

    A fusion reactor is provided having a near spherical-shaped plasma with a modest central opening through which straight segments of toroidal field coils extend that carry electrical current for generating a toroidal magnet plasma confinement fields. By retaining only the indispensable components inboard of the plasma torus, principally the cooled toroidal field conductors and in some cases a vacuum containment

  7. DT Beam Fusion Reactor

    Microsoft Academic Search

    F. J. Wessel; N. Rostoker

    1998-01-01

    The Beam Fusion Reactor (BFR) is based on a field-reversed configuration and confined ion energies in the range of hundreds of keV. Repetitively pulsed, intense ion beams sustain the ion distributions and provide current drive. In the BFR the ion orbit size is comparable to the dimensions of the confined plasma and the expectation is for classical transport of the

  8. Multisensor data fusion

    Microsoft Academic Search

    P. K. Varshney

    1997-01-01

    Multisensor data fusion refers to the acquisition, processing and synergistic combination of information gathered by various knowledge sources and sensors to provide a better understanding of a phenomenon. It is a fascinating and rapidly evolving field that has generated a lot of excitement in the research and development community. These concepts are being applied to a wide variety of fields

  9. Compact fusion reactors

    SciTech Connect

    Krakowski, R.A.; Hagenson, R.L.

    1983-01-01

    Compact, high-power-density approaches to fusion power are proposed to improve economic viability through the use of less-advanced technology in systems of considerably reduced scale. The rationale for and the means by which these systems can be achieved are discussed, as are unique technological problems.

  10. Soldier systems sensor fusion

    Microsoft Academic Search

    Kathryne M. Brubaker

    1998-01-01

    This paper addresses sensor fusion and its applications in emerging Soldier Systems integration and the unique challenges associated with the human platform. Technology that,provides the highest operational payoff in a lightweight warrior system must not only have enhanced capabilities, but have low power components resulting in order of magnitude reductions coupled with significant cost reductions. These reductions in power and

  11. Context based multimodal fusion

    Microsoft Academic Search

    Norbert Pfleger

    2004-01-01

    We present a generic approach to multimodal fusion which we call context based multimodal integration. Key to this approach is that every multimodal input event is interpreted and enriched with respect to its local turn context. This local turn context comprises all previously recognized input events and the dialogue state that both belong to the same user turn. We show

  12. Fusion Chamber Technology Publications

    E-print Network

    California at Los Angeles, University of

    Coatings on the Flow Partitioning Between Parallel Channels in Self-Cooled Liquid Metal Blankets," Fusion, Z. "Thermal and Mechanical Properties of Ceramic Blanket Particle Bed Materials: Numerical. Abelson, R.D., Abdou, M.A. "Experimental Measurement of the Interface Heat Conductance Between

  13. Multisensor data fusion architecture

    Microsoft Academic Search

    A. H. G. Al-Dhaher; D. Mackesy

    2004-01-01

    In this work we present multi-sensor data fusion architecture. The objective of the architecture is to obtain fused measured data that represent the measured parameter as accurate as possible. The architecture is based on the use of adaptive Kalman filter formed by using Kalman filter and fuzzy logic techniques. Measurements generated from each sensor are fed into an adaptive Kalman

  14. Enhanced image capture through fusion

    NASA Technical Reports Server (NTRS)

    Burt, Peter J.; Hanna, Keith; Kolczynski, Raymond J.

    1993-01-01

    Image fusion may be used to combine images from different sensors, such as IR and visible cameras, to obtain a single composite with extended information content. Fusion may also be used to combine multiple images from a given sensor to form a composite image in which information of interest is enhanced. We present a general method for performing image fusion and show that this method is effective for diverse fusion applications. We suggest that fusion may provide a powerful tool for enhanced image capture with broad utility in image processing and computer vision.

  15. Fusion Probability in Dinuclear System

    E-print Network

    Juhee Hong

    2015-03-26

    Fusion can be described by the time evolution of a dinuclear system with two degrees of freedom, the relative motion and transfer of nucleons. In the presence of the coupling between two collective modes, we solve the Fokker-Planck equation in a locally harmonic approximation. The potential of a dinuclear system has the quasifission barrier and the inner fusion barrier, and the escape rates can be calculated by the Kramers' model. To estimate the fusion probability, we calculate the quasifission rate and the fusion rate. We investigate the coupling effects on the fusion probability and the cross section of evaporation residue.

  16. Fusion Ignition Research Experiment (FIRE)

    NSDL National Science Digital Library

    A division of the Princeton Plasma Research Laboratory (described in the July 1, 1994 Scout Report for Science & Engineering), the Fusion Ignition Research Experiment (FIRE) aims "to attain, explore, understand and optimize alpha-dominated plasmas to provide knowledge for the design of attractive Magnetic Fusion systems." Up-to-date, downloadable reports (.pdf and MS Word formats) contain background information and reviews of US fusion policy, Snowmass Fusion Summer Study working group summaries, FIRE reports on physics and engineering design considerations, and an engineering appendix. Clearly displayed, this site harbors a wealth of dense information for researchers interested in the design of magnetic fusion systems.

  17. Accelerators for heavy ion fusion

    SciTech Connect

    Bangerter, R.O.

    1985-10-01

    Large fusion devices will almost certainly produce net energy. However, a successful commercial fusion energy system must also satisfy important engineering and economic constraints. Inertial confinement fusion power plants driven by multi-stage, heavy-ion accelerators appear capable of meeting these constraints. The reasons behind this promising outlook for heavy-ion fusion are given in this report. This report is based on the transcript of a talk presented at the Symposium on Lasers and Particle Beams for Fusion and Strategic Defense at the University of Rochester on April 17-19, 1985.

  18. The path to fusion power.

    PubMed

    Llewellyn Smith, Chris; Ward, David

    2007-04-15

    Fusion is potentially an environmentally responsible and intrinsically safe source of essentially limitless power. It should be possible to build viable fusion power stations, and it looks as if the cost of fusion power will be reasonable. But time is needed to further develop the technology and to test in power station conditions the materials that would be used in their construction. Assuming no major adverse surprises, an orderly fusion development programme could lead to a prototype fusion power station putting electricity into the grid within 30 years, with commercial fusion power following some 10 or more years later. In the second half of the century, fusion could therefore be an important part of the portfolio of measures that are needed to cope with rising demand for energy in an environmentally responsible manner. In this paper, we describe the basics of fusion, its potential attractions, the status of fusion R&D, the remaining challenges and how they will be tackled at the International Tokamak Experimental Reactor and the proposed International Fusion Materials Irradiation Facility, and the timetable for the subsequent commercialization of fusion power. PMID:17272246

  19. Research on fusion neutron sources

    SciTech Connect

    Gryaznevich, M. P. [Tokamak Solutions UK, Culham Science Centre, Abingdon, OXON, OX133DB (United Kingdom)

    2012-06-19

    The use of fusion devices as powerful neutron sources has been discussed for decades. Whereas the successful route to a commercial fusion power reactor demands steady state stable operation combined with the high efficiency required to make electricity production economic, the alternative approach to advancing the use of fusion is free of many of complications connected with the requirements for economic power generation and uses the already achieved knowledge of Fusion physics and developed Fusion technologies. 'Fusion for Neutrons' (F4N), has now been re-visited, inspired by recent progress achieved on comparably compact fusion devices, based on the Spherical Tokamak (ST) concept. Freed from the requirement to produce much more electricity than used to drive it, a fusion neutron source could be efficiently used for many commercial applications, and also to support the goal of producing energy by nuclear power. The possibility to use a small or medium size ST as a powerful or intense steady-state fusion neutron source (FNS) is discussed in this paper in comparison with the use of traditional high aspect ratio tokamaks. An overview of various conceptual designs of compact fusion neutron sources based on the ST concept is given and they are compared with a recently proposed Super Compact Fusion Neutron Source (SCFNS), with major radius as low as 0.5 metres but still able to produce several MW of neutrons in a steady-state regime.

  20. The Need for Fusion Propulsion

    NASA Technical Reports Server (NTRS)

    Cassibry, Jason

    2005-01-01

    Fusion propulsion is inevitable if the human race remains dedicated to exploration of the solar system. There are fundamental reasons why fusion surpasses more traditional approaches to routine crewed missions to Mars, crewed missions to the outer planets, and deep space high speed robotic missions, assuming that reduced trip times, increased payloads, and higher available power are desired. A recent series of informal discussions were held among members from government, academia, and industry concerning fusion propulsion. We compiled a sufficient set of arguments for utilizing fusion in space. If the U.S. is to lead the effort and produce a working system in a reasonable amount of time, NASA must take the initiative, relying on, but not waiting for, DOE guidance. In this talk those arguments for fusion propulsion are presented, along with fusion enabled mission examples, fusion technology trade space, and a proposed outline for future efforts.

  1. Economics of less invasive spinal surgery: an analysis of hospital cost differences between open and minimally invasive instrumented spinal fusion procedures during the perioperative period

    PubMed Central

    Lucio, John C; VanConia, R Brent; DeLuzio, Kevin J; Lehmen, Jeffrey A; Rodgers, Jody A; Rodgers, WB

    2012-01-01

    Background There is great debate about the costs and benefits of technology-driven medical interventions such as instrumented lumbar fusion. With most analyses using charge data, the actual costs incurred by medical institutions performing these procedures are not well understood. The object of the current study was to examine the differences in hospital operating costs between open and minimally invasive spine surgery (MIS) during the perioperative period. Methods Data were collected in the form of a prospective registry from a community hospital after specific Institutional Review Board approval was obtained. The analysis included consecutive adult patients being surgically treated for degenerative conditions of the lumbar spine, with either an MIS or open approach for two-level instrumented lumbar fusion. Patient outcomes and costs were collected for the perioperative period. Hospital operating costs were grouped by hospitalization/operative procedure, transfusions, reoperations, and residual events (health care interactions). Results One hundred and one open posterior lumbar interbody fusion (Open group) and 109 MIS patients were treated primarily for stenosis coupled with instability (39.6% and 59.6%, respectively). Mean total hospital costs were $27,055.53 for the Open group and $24,320.16 for the MIS group. This represents a statistically significant cost savings of $2,825.37 (10.4% [95% confidence interval: $522.51–$5,128.23]) when utilizing MIS over traditional Open techniques. Additionally, residual events, complications, and blood transfusions were significantly more frequent in the Open group, compared to the MIS group. Conclusions/level of evidence Utilizing minimally invasive techniques for instrumented spinal fusion results in decreased hospital operating costs compared to similar open procedures in the early perioperative period. Additionally, patient benefits of minimally invasive techniques include significantly less blood loss, shorter hospital stays, lower complication rate, and a lower number of residual events. Long-term outcome comparisons are needed to evaluate the efficacy of the two treatments. Level of evidence: III Clinical relevance This work represents a true cost-of-operating comparison between open and MIS approaches for lumbar spine fusion, which has relevance to surgeons, hospitals and payers in medical decision-making. PMID:22952415

  2. The "Fusion EXPO" in Brussels

    NASA Astrophysics Data System (ADS)

    Ongena, Jef; van Oost, Guido; Paris, Pierre

    1997-11-01

    From the 22nd of october until the 28th of november, a fusion exhibit is being organized in the capital of Europe, Brussels. The aim of the exhibit is threefold : (i) give a feeling for the problem of our future energy supply (ii) show that fusion is possibly one of the most interesting of the very few options we have for our long term energy supply and (iii) to increase public awareness on fusion research. The exhibit deals mainly with magnetic fusion, with some part devoted to inertial fusion. Large photographs of different European fusion devices, maquettes of JET, Tore Supra etc..., parts of existing magnetic fusion experiments (antennas, limiters, etc...) should give the public an idea of what fusion research means in terms of real life. Especially school classes are invited and will be given guided tours of the exhibit. In particular also the members of the European Parliament are invited to the exhibit, and a special symposiom on fusion research will be organized to inform them on the need of this kind of research and the important benefits fusion has to offer over all other known energy sources. The poster will give a visual overview of the exhibit, next to providing some practical experience gathered until then. New materials for public use and especially prepared for this exhibit will be on display.

  3. Computational fusion magnetohydrodynamics

    SciTech Connect

    Grimm, R.C.

    1984-01-01

    Simple magnetohydrodynamic models provide the framework for much of our understanding of the macroscopic behavior of magnetically confined laboratory plasmas. In even the simplest of models, however, the many different time and spatial scales, the multidimensionality, and the nonlinearity of the equations make finding solutions difficult. In realistic geometries obtaining quantitative results to aid our understanding, to interpret experiment, and to design new devices, involves the development of large scale numerical codes. During the past decade considerable effort has been extended in the fusion community to develop equilibrium, linear stability, and nonlinear time evolution codes in two and three dimensions, some of which have had a considerable impact on the fusion program. An overview of the various types of codes and numerical methods is given. Emphasis is on the spectrum of linear perturbations and ideal MHD stability, boundary layer methods and resistive MHD stability, and modeling of nonlinear, time evolution resistive MHD phenomena in tokamak configurations.

  4. ProFusion

    NSDL National Science Digital Library

    Originally developed by the University of Kansas Information Telecommunication and Technology Center, and School of Engineering DesignLab (see the July 25, 1997 Scout Report), ProFusion is a meta-search and "deep Web" search engine. Purchased by Intelliseek and fitted with a new interface, ProFusion allows users to search over 1,000 search sites, "including search engines, Web directories, discussion groups, news sources, online publications, and archives." Visitors can also perform targeted searches of vertical search sources, selecting which databases to query. Two other new features include an alert service that tracks changes to selected pages and notifies users by email and a Search Assistant that suggests results from search engine groups relevant to a query in addition to the general Web results. Worth a spin around the block.

  5. High Level Information Fusion (HLIF) with nested fusion loops

    NASA Astrophysics Data System (ADS)

    Woodley, Robert; Gosnell, Michael; Fischer, Amber

    2013-05-01

    Situation modeling and threat prediction require higher levels of data fusion in order to provide actionable information. Beyond the sensor data and sources the analyst has access to, the use of out-sourced and re-sourced data is becoming common. Through the years, some common frameworks have emerged for dealing with information fusion—perhaps the most ubiquitous being the JDL Data Fusion Group and their initial 4-level data fusion model. Since these initial developments, numerous models of information fusion have emerged, hoping to better capture the human-centric process of data analyses within a machine-centric framework. 21st Century Systems, Inc. has developed Fusion with Uncertainty Reasoning using Nested Assessment Characterizer Elements (FURNACE) to address challenges of high level information fusion and handle bias, ambiguity, and uncertainty (BAU) for Situation Modeling, Threat Modeling, and Threat Prediction. It combines JDL fusion levels with nested fusion loops and state-of-the-art data reasoning. Initial research has shown that FURNACE is able to reduce BAU and improve the fusion process by allowing high level information fusion (HLIF) to affect lower levels without the double counting of information or other biasing issues. The initial FURNACE project was focused on the underlying algorithms to produce a fusion system able to handle BAU and repurposed data in a cohesive manner. FURNACE supports analyst's efforts to develop situation models, threat models, and threat predictions to increase situational awareness of the battlespace. FURNACE will not only revolutionize the military intelligence realm, but also benefit the larger homeland defense, law enforcement, and business intelligence markets.

  6. Data fusion handoff within a federation of fusion systems

    NASA Astrophysics Data System (ADS)

    Shea, Peter J.; Roskamp, Bryce

    2007-09-01

    As the military continues to move forward with an increased number of sensor and fusion systems, it becomes necessary for these systems to be able to communicate efficiently and effectively. In these environments there are multiple sensor and fusion systems that in the past have operated independently of one another. As an increasing number of systems become available, eventually an overlap in the coverage area occurs between these fusion systems. This results in a need for coordination between these semi-autonomous fusion systems. Short of a complete redesign of all the fusion systems, a solution is required to address the handoff of data between these systems. The primary goal of this paper is to describe a data fusion handoff capability that is able to augment these existing systems. This is accomplished by the use of a Handoff Manager that is added to each fusion system. The Handoff Manager is responsible for developing a global representation the track information displayed onboard its own fusion system that is common with the other members of the federation of fusion systems. This is accomplished by using a global track numbering scheme that requires communication and adjudication between the multiple Handoff Manager components that are present on the different fusion systems within the federation. This paper will define the data fusion handoff problem and describe our approach for handling the data fusion handoff problem within the context of overlapping and non-overlapping sensor environments. We will conclude with a discussion of results for a sample problem and of the path forward.

  7. Sensor data fusion

    Microsoft Academic Search

    Louis-françois Pau

    1988-01-01

    This paper reviews some knowledge representation approaches devoted to the sensor fusion problem, as encountered whenever images, signals, text must be combined to provide the input to a controller or to an inference procedure. The basic steps involved in the derivation of the knowledge representation scheme, are:(A)locate a representation, based on exogeneous context information(B)compare two representations to find out if

  8. Pulsed High Density Fusion

    NASA Astrophysics Data System (ADS)

    Slough, John

    2000-10-01

    Based on FRC acceleration experiments, together with confinement scaling observed in past FRC experiments, a method has been determined by which an FRC can be compressed to high density and brought to ignition conditions in a rapid, repetitive manner. This regime is referred to as the Pulsed High Density (PHD) regime of MFE. Unlike MTF, the upper boundary of this regime remains below the density limit imposed by material strength limitations. Data from various FRC experiments yield a scaling with size and density such that at a density of 10^24 m-3, a fusion gain > 1 can be achieved at a radius ~ 1 cm. The energy necessary for burn is transferred to the FRC in the form of translational energy, which is produced by an inductive magnetized plasma accelerator (IMPAC) that is capable of repetitive pulsing. The simplicity of this approach to fusion lies in the fact that the directed energy of the FRC mass is much greater than the FRC internal energy, so that the confining magnetic fields, as well as accelerating fields, need to be no greater than required to contain the low-pressure FRC generated in the source coil ( ~ 0.4 T). The conversion of the FRC directed energy into thermal energy occurs only after the FRC has reached the burn chamber where the FRC is slowed and compressed to fusion conditions. The goal of a concept exploration experiment would be the construction of an IMPAC device capable of producing a FRC plasma where all key parameters can be brought to within an order of magnitude of that required for a Q ~1 fusion burn. Details of such an experiment will be discussed.

  9. Fusion development and technology

    SciTech Connect

    Montgomery, D.B.

    1992-01-01

    This report discusses the following: superconducting magnet technology; high field superconductors; advanced magnetic system and divertor development; poloidal field coils; gyrotron development; commercial reactor studies--aries; ITER physics: alpha physics and alcator R D for ITER; lower hybrid current drive and heating in the ITER device; ITER superconducting PF scenario and magnet analysis; ITER systems studies; and safety, environmental and economic factors in fusion development.

  10. (Fusion energy research)

    SciTech Connect

    Phillips, C.A. (ed.)

    1988-01-01

    This report discusses the following topics: principal parameters achieved in experimental devices (FY88); tokamak fusion test reactor; Princeton beta Experiment-Modification; S-1 Spheromak; current drive experiment; x-ray laser studies; spacecraft glow experiment; plasma deposition and etching of thin films; theoretical plasma; tokamak modeling; compact ignition tokamak; international thermonuclear experimental reactor; Engineering Department; Project Planning and Safety Office; quality assurance and reliability; and technology transfer.

  11. Tokamak fusion power reactors

    Microsoft Academic Search

    W. M. Stacey Jr.; M. A. Abdou

    1978-01-01

    The major parameters and corresponding economic characteristics of a representative class of commercial Tokamak fusion power reactors are examined as a function of four major design parameters: plasma beta-t, toroidal magnetic field strength, first-wall lifetime, and power output. It is shown that for beta-t greater than or equal to 0.06, the minimum cost of energy is obtained for toroidal field

  12. Cosmic Data Fusion

    Microsoft Academic Search

    S. L. Bridle

    2005-01-01

    I will discuss our work on cosmic data fusion: the comparison and combination of various cosmological data sets to estimate cosmological parameters. We find good agreement on cosmological parameters between galaxy velocities, CMB and Type 1a supernovae with 95 per cent confidence limits 0.64 < h < 0.86, 0.17 < &Omegam < 0.39 and 0.98 < sigma8 < 1.37. We

  13. Fusion Policy Advisory Committee FINAL REPORT

    E-print Network

    Fusion Policy Advisory Committee (FPAC) FINAL REPORT September 1990 Report of the Technical Panel on Magnetic Fusion of the Energy Research Advisory Board Washington, D .C. 20585 #12;#12;Fusion Policy of your Fusion Policy Advisory Committee. It presents a fusion policy that the Committee believes

  14. Stabilized Spheromak Fusion Reactors

    SciTech Connect

    Fowler, T

    2007-04-03

    The U.S. fusion energy program is focused on research with the potential for studying plasmas at thermonuclear temperatures, currently epitomized by the tokamak-based International Thermonuclear Experimental Reactor (ITER) but also continuing exploratory work on other plasma confinement concepts. Among the latter is the spheromak pursued on the SSPX facility at LLNL. Experiments in SSPX using electrostatic current drive by coaxial guns have now demonstrated stable spheromaks with good heat confinement, if the plasma is maintained near a Taylor state, but the anticipated high current amplification by gun injection has not yet been achieved. In future experiments and reactors, creating and maintaining a stable spheromak configuration at high magnetic field strength may require auxiliary current drive using neutral beams or RF power. Here we show that neutral beam current drive soon to be explored on SSPX could yield a compact spheromak reactor with current drive efficiency comparable to that of steady state tokamaks. Thus, while more will be learned about electrostatic current drive in coming months, results already achieved in SSPX could point to a productive parallel development path pursuing auxiliary current drive, consistent with plans to install neutral beams on SSPX in the near future. Among possible outcomes, spheromak research could also yield pulsed fusion reactors at lower capital cost than any fusion concept yet proposed.

  15. COLLABORATIVE: FUSION SIMULATION PROGRAM

    SciTech Connect

    Chang, Choong Seock

    2012-06-05

    New York University, Courant Institute of Mathematical Sciences, participated in the ���¢��������Fusion Simulation Program (FSP) Planning Activities���¢������� [http://www.pppl.gov/fsp], with C.S. Chang as the institutional PI. FSP���¢��������s mission was to enable scientific discovery of important new plasma phenomena with associated understanding that emerges only upon integration. This requires developing a predictive integrated simulation capability for magnetically-confined fusion plasmas that are properly validated against experiments in regimes relevant for producing practical fusion energy. Specific institutional goal of the New York University was to participate in the planning of the edge integrated simulation, with emphasis on the usage of large scale HPCs, in connection with the SciDAC CPES project which the PI was leading. New York University successfully completed its mission by participating in the various planning activities, including the edge physics integration, the edge science drivers, and the mathematical verification. The activity resulted in the combined report that can be found in http://www.pppl.gov/fsp/Overview.html. Participation and presentations as part of this project are listed in a separation file.

  16. Chase Delphi study on fusion

    NASA Astrophysics Data System (ADS)

    Meyer, A. J.

    1982-10-01

    The ongoing Chase Delphi study of fusion power has employed a panel of over 100 experts from 13 countries. The use of fusion for synfuel production was emphasized. The panelists believed that the length of time to successful demonstrations and commercialization of fusion could be substantially reduced over current estimates given optimal funding, and that a hydrocarbon producing reactor is feasible with minimal adverse impact on the environment.

  17. Directions for improved fusion reactors

    Microsoft Academic Search

    R. A. Krakowski; R. L. Miller; J. G. Delene

    1986-01-01

    Conceptual fusion reactor studies over the past 10 to 15 years have projected systems that may be too large, complex, and costly to be of commercial interest. One main direction for improved fusion reactors points towards smaller, higher-power-density approaches. First-order economic issues (i.e., unit direct cost and cost of electricity) are used to support the need for more compact fusion

  18. Sensor fusion for synthetic vision

    NASA Technical Reports Server (NTRS)

    Pavel, M.; Larimer, J.; Ahumada, A.

    1991-01-01

    Display methodologies are explored for fusing images gathered by millimeter wave sensors with images rendered from an on-board terrain data base to facilitate visually guided flight and ground operations in low visibility conditions. An approach to fusion based on multiresolution image representation and processing is described which facilitates fusion of images differing in resolution within and between images. To investigate possible fusion methods, a workstation-based simulation environment is being developed.

  19. General Atomics Fusion Group Educational Home Page

    NSDL National Science Digital Library

    This site from the General Atomics Energy Group features a collection of educational resources on fusion. Both naturally occuring fusion and fusion as an energy source are included. Resources for teachers to use in the classroom are included.

  20. Helium Find Thaws the Cold Fusion Trail.

    ERIC Educational Resources Information Center

    Pennisi, E.

    1991-01-01

    Reported is a study of cold fusion in which trace amounts of helium, possible evidence of an actual fusion reaction, were found. Research methodology is detailed. The controversy over the validity of experimental results with cold fusion are reviewed. (CW)

  1. Mitochondrial Fusion and Fission in Mammals

    E-print Network

    Chan, David

    Mitochondrial Fusion and Fission in Mammals David C. Chan Division of Biology, California Institute dynamics, organelle morphology, membrane fusion, membrane trafficking Abstract Eukaryotic cells maintain. Unbalanced fission leads to mitochondrial fragmentation, and un- balanced fusion leads to mitochondrial

  2. Information fusion for obstacle recognition in visible and infrared images

    Microsoft Academic Search

    Anca Apatean; Alexandrina Rogozan; Abdelaziz Bensrhair

    2009-01-01

    We propose the information fusion of visible and infrared images for a pedestrian-vehicle SVM-based classification. Different types of fusion methods are presented: data fusion, feature fusion, matching score fusion and decision fusion. Data - level fusion assumes that the raw information is combined at the pixel level. The fusion at the feature level produces a feature vector integrating both visual

  3. Image fusion using statistical intensity fusion and adaptive unsharp masking

    Microsoft Academic Search

    A. Onur Karali; Serdar Cakir; O. Erman Okman; Tayfun Aytac

    2012-01-01

    Image fusion is an image processing technique that is applied in various application areas. Image fusion is adopted for target detection and recognition in surveillance systems, recognition and diagnosis for medical imaging systems and for surface characteristics determination on multi-spectral satellite images. Structure of the techniques and the content of the resulting images vary with respect to the application area.

  4. Data fusion handoff within a federation of fusion systems

    Microsoft Academic Search

    Peter J. Shea; Bryce Roskamp

    2007-01-01

    As the military continues to move forward with an increased number of sensor and fusion systems, it becomes necessary for these systems to be able to communicate efficiently and effectively. In these environments there are multiple sensor and fusion systems that in the past have operated independently of one another. As an increasing number of systems become available, eventually an

  5. Muon-catalyzed fusion: a new direction in fusion research

    SciTech Connect

    Jones, S.E.

    1986-01-01

    In four years of intensive research, muon-catalyzed fusion has been raised from the level of a scientific curiosity to a potential means of achieving clean fusion energy. This novel approach to fusion is based on the fact that a sub-atomic particle known as a ''muon'' can induce numerous energy-releasing fusion reactions without the need for high temperatures or plasmas. Thus, the muon serves as a catalyst to facilitate production for fusion energy. The success of the research effort stems from the recent discovery of resonances in the reaction cycle which make the muon-induced fusion process extremely efficient. Prior estimates were pessimistic in that only one fusion per muon was expected. In that case energy balance would be impossible since energy must be invested to generate the muons. However, recent work has gone approximately half-way to energy balance and further improvements are being worked on. There has been little time to assess the full implications of these discoveries. However, various ways to use muon-catalyzed fusion for electrical power production are now being explored.

  6. Detecting and visualizing gene fusions.

    PubMed

    Supper, Jochen; Gugenmus, Claudia; Wollnik, Johannes; Drueke, Tanja; Scherf, Matthias; Hahn, Alexander; Grote, Korbinian; Bretschneider, Nancy; Klocke, Bernward; Zinser, Christian; Cartharius, Kerstin; Seifert, Martin

    2013-01-01

    In recent years, gene fusions have gained significant recognition as biomarkers. They can assist treatment decisions, are seldom found in normal tissue and are detectable through Next-generation sequencing (NGS) of the transcriptome (RNA-seq). To transform the data provided by the sequencer into robust gene fusion detection several analysis steps are needed. Usually the first step is to map the sequenced transcript fragments (RNA-seq) to a reference genome. One standard application of this approach is to estimate expression and detect variants within known genes, e.g. SNPs and indels. In case of gene fusions, however, completely novel gene structures have to be detected. Here, we describe the detection of such gene fusion events based on our comprehensive transcript annotation (ElDorado). To demonstrate the utility of our approach, we extract gene fusion candidates from eight breast cancer cell lines, which we compare to experimentally verified gene fusions. We discuss several gene fusion events, like BCAS3-BCAS4 that was only detected in the breast cancer cell line MCF7. As supporting evidence we show that gene fusions occur more frequently in copy number enriched regions (CNV analysis). In addition, we present the Transcriptome Viewer (TViewer) a tool that allows to interactively visualize gene fusions. Finally, we support detected gene fusions through literature mining based annotations and network analyses. In conclusion, we present a platform that allows detecting gene fusions and supporting them through literature knowledge as well as rich visualization capabilities. This enables scientists to better understand molecular processes, biological functions and disease associations, which will ultimately lead to better biomedical knowledge for the development of biomarkers for diagnostics and therapies. PMID:23036331

  7. Multibiometric Cryptosystems based on Feature Level Fusion

    E-print Network

    of the proposed feature level fusion framework using two well- known biometric cryptosystems, namely, fuzzy vault security, biometric cryptosystem, fuzzy vault, fuzzy commitment, fusion I. INTRODUCTION Multibiometric

  8. Fission and Fusion Game

    NSDL National Science Digital Library

    2012-09-28

    In this activity, students play a board game where they learn the characteristics of and differences between fission and fusion, as well as the real world applications of these energy-releasing reactions. Reproducible game cards and and game board are included in the resource. The investigation supports material presented in chapter 3, "What Heats the Earth's Interior?" in the textbook, Energy flow, part of the Global System Science, an interdisciplinary course for high school students that emphasizes how scientists from a wide variety of fields work together to understand significant problems of global impact.

  9. Peregrinations on cold fusion

    SciTech Connect

    Turner, L.

    1989-01-01

    Attention is focused on the possibility of resonance-enhanced deuteron Coulomb barrier penetration. Because of the many-body nature of the interactions of room-temperature deuterons diffusing through a lattice possessing deuterons in many of the interstitial positions, the diffusing deuterons can resonate on the atomic scale in the potential wells bounded by the ascending walls of adjacent Coulomb barriers and thereby penetrate the Coulomb barriers in a fashion vastly underestimated by two-body calculations in which wells for possible resonance are absent. Indeed, perhaps the lack of robust reproducibility in cold fusion originates from the narrowness of such transmission resonances. 4 refs., 1 fig.

  10. Fusion reactor pumped laser

    DOEpatents

    Jassby, Daniel L. (Princeton, NJ)

    1988-01-01

    A nuclear pumped laser capable of producing long pulses of very high power laser radiation is provided. A toroidal fusion reactor provides energetic neutrons which are slowed down by a moderator. The moderated neutrons are converted to energetic particles capable of pumping a lasing medium. The lasing medium is housed in an annular cell surrounding the reactor. The cell includes an annular reflecting mirror at the bottom and an annular output window at the top. A neutron reflector is disposed around the cell to reflect escaping neutrons back into the cell. The laser radiation from the annular window is focused onto a beam compactor which generates a single coherent output laser beam.

  11. Journal of Fusion Energy, Vol. 18, No. 4, 1999 Report of the FEAC Inertial Fusion Energy Review Panel

    E-print Network

    Abdou, Mohamed

    Journal of Fusion Energy, Vol. 18, No. 4, 1999 Report of the FEAC Inertial Fusion Energy Review. S. Department of Energy Fusion Energy Advisory Committee (FEAC) review of its Inertial Fusion Energy of California at San Diego. KEY WORDS: Fusion; fusion science; fusion energy; inertial fusion energy. I. SUMMARY

  12. Fusion algebra of critical percolation

    E-print Network

    Jorgen Rasmussen; Paul A. Pearce

    2007-08-08

    We present an explicit conjecture for the chiral fusion algebra of critical percolation considering Virasoro representations with no enlarged or extended symmetry algebra. The representations we take to generate fusion are countably infinite in number. The ensuing fusion rules are quasi-rational in the sense that the fusion of a finite number of these representations decomposes into a finite direct sum of these representations. The fusion rules are commutative, associative and exhibit an sl(2) structure. They involve representations which we call Kac representations of which some are reducible yet indecomposable representations of rank 1. In particular, the identity of the fusion algebra is a reducible yet indecomposable Kac representation of rank 1. We make detailed comparisons of our fusion rules with the recent results of Eberle-Flohr and Read-Saleur. Notably, in agreement with Eberle-Flohr, we find the appearance of indecomposable representations of rank 3. Our fusion rules are supported by extensive numerical studies of an integrable lattice model of critical percolation. Details of our lattice findings and numerical results will be presented elsewhere.

  13. Enhanced image capture through fusion

    Microsoft Academic Search

    Peter J. Burt; Raymond J. Kolczynski

    1993-01-01

    The authors present an extension to the pyramid approach to image fusion. The modifications address problems that were encountered with past implementations of pyramid-based fusion. In particular, the modifications provide greater shift invariance and immunity to video noise, and provide at least a partial solution to the problem of combining components that have roughly equal salience but opposite contrasts. The

  14. Frontiers of Fusion Materials Science

    E-print Network

    Frontiers of Fusion Materials Science Presented by S.J. Zinkle, Oak Ridge National Laboratory ¥The mission of the Fusion Materials Sciences program is to ÒAdvance the materials science base (alloys and ceramic composites), insulators, etc. ¥TodayÕs presentation: Materials science highlights

  15. Cellulose binding domain fusion proteins

    DOEpatents

    Shoseyov, Oded (Karmey Yosef, IL); Shpiegl, Itai (Rehovot, IL); Goldstein, Marc A. (Davis, CA); Doi, Roy H. (Davis, CA)

    1998-01-01

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques.

  16. Cellulose binding domain fusion proteins

    DOEpatents

    Shoseyov, O.; Yosef, K.; Shpiegl, I.; Goldstein, M.A.; Doi, R.H.

    1998-02-17

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques. 16 figs.

  17. Overview of ORNL Fusion Program

    E-print Network

    Sciences 4 Leadership Computing Facility 5 Fusion Energy Div. 6 Measurement Science and Systems Div. 7, 2009 #12;Develop the understanding required for an attractive fusion energy source through integrated Flux Isotope Reactor #12;Molecular dynamics simulation of particle surface interactions Controlled

  18. Inhibition of Hendra Virus Fusion

    PubMed Central

    Porotto, M.; Doctor, L.; Carta, P.; Fornabaio, M.; Greengard, O.; Kellogg, G. E.; Moscona, A.

    2006-01-01

    Hendra virus (HeV) is a recently identified paramyxovirus that is fatal in humans and could be used as an agent of bioterrorism. The HeV receptor-binding protein (G) is required in order for the fusion protein (F) to mediate fusion, and analysis of the triggering/activation of HeV F by G should lead to strategies for interfering with this key step in viral entry. HeV F, once triggered by the receptor-bound G, by analogy with other paramyxovirus F proteins, undergoes multistep conformational changes leading to a six-helix bundle (6HB) structure that accomplishes fusion of the viral and cellular membranes. The ectodomain of paramyxovirus F proteins contains two conserved heptad repeat regions (HRN and HRC) near the fusion peptide and the transmembrane domains, respectively. Peptides derived from the HRN and HRC regions of F are proposed to inhibit fusion by preventing F, after the initial triggering step, from forming the 6HB structure that is required for fusion. HeV peptides have previously been found to be effective at inhibiting HeV fusion. However, we found that a human parainfluenza virus 3 F-peptide is more effective at inhibiting HeV fusion than the comparable HeV-derived peptide. PMID:16973588

  19. Magnetized target fusion. An overview

    SciTech Connect

    Kirkpatrick, R.C.; Lindemuth, I.R.; Ward, M.S. [Los Alamos National Lab., NM (United States)

    1995-05-01

    The magnetized target fusion (MTF) concept is explained, and the underlying principles are discussed. The necessity of creating a target plasma and the advantage of decoupling its creation from the implosion used to achieve fusion ignition are explained. The Sandia National Laboratories {Phi}-target experiments is one concrete example of the MTF concept, but other experiments have involved some elements of MTF. Lindl-Widner diagrams are used to elucidate the parameter space available to MTF and the physics of MTF ignition. Magnetized target fusion has both limitations and advantages relative to inertial confinement fusion. The chief advantage is that the driver for an MTF target can be orders of magnitude less powerful and intense than what is required for other inertial fusion approaches. A number of critical issues challenge the practical realization of MTF. Past experience, critical issues, and potential integral MTF experiments are discussed. 25 refs., 12 figs.

  20. Activity : Fusion Reactions

    NSDL National Science Digital Library

    2007-12-12

    This activity gives students an opportunity to learn about the elements created in the cores of high-mass stars by fusion reactions. They will discover that all stars start by burning hydrogen and end up creating many heavier elements inside their cores, elements that will be released into space when it dies in a supernova explosion. Students associate a layer with an element that is being produced by the high-mass star. This will illustrate that as the temperature of the star increases with depth, the ash of each burning stage becomes the fuel for the next stage. Surrounding the core of iron nuclei is a layer of silicon fusion, then magnesium, then neon, then oxygen, then carbon, then helium, and lastly, in the relatively cool periphery of the core, hydrogen fuses into helium. Students will draw their own version of the onion-like nature of the core of a star based on the model and explain the process that occurs at each layer.

  1. Inertial Confinement Fusion

    NASA Astrophysics Data System (ADS)

    Powers, L.; Condouris, R.; Kotowski, M.; Murphy, P. W.

    This issue of the ICF Quarterly contains seven articles that describe recent progress in Lawrence Livermore National Laboratory's ICF program. The Department of Energy recently initiated an effort to design a 1-2 MJ glass laser, the proposed National Ignition Facility (NIF). These articles span various aspects of a program which is aimed at moving forward toward such a facility by continuing to use the Nova laser to gain understanding of NIF-relevant target physics, by developing concepts for an NIF laser driver and by envisioning a variety of applications for larger ICF facilities. This report discusses research on the following topics: Stimulated Rotational Raman Scattering in Nitrogen; A Maxwell Equation Solver in LASNEX for the Simulation of Moderately Intense Ultrashort Pulse Experiments; Measurements of Radial Heat-Wave Propagation in Laser-Produced Plasmas; Laser-Seeded Modulation Growth on Directly Driven Foils; Stimulated Raman Scattering in Large-Aperture, High-Fluence Frequency-Conversion Crystals; Fission Product Hazard Reduction Using Inertial Fusion Energy; and the Use of Inertial Confinement Fusion for Nuclear Weapons Effects Simulations.

  2. Inertial confinement fusion

    SciTech Connect

    Powers, L.; Condouris, R.; Kotowski, M.; Murphy, P.W. (eds.)

    1992-01-01

    This issue of the ICF Quarterly contains seven articles that describe recent progress in Lawrence Livermore National Laboratory's ICF program. The Department of Energy recently initiated an effort to design a 1--2 MJ glass laser, the proposed National Ignition Facility (NIF). These articles span various aspects of a program which is aimed at moving forward toward such a facility by continuing to use the Nova laser to gain understanding of NIF-relevant target physics, by developing concepts for an NIF laser driver, and by envisioning a variety of applications for larger ICF facilities. This report discusses research on the following topics: Stimulated Rotational Raman Scattering in Nitrogen; A Maxwell Equation Solver in LASNEX for the Simulation of Moderately Intense Ultrashort Pulse Experiments; Measurements of Radial Heat-Wave Propagation in Laser-Produced Plasmas; Laser-Seeded Modulation Growth on Directly Driven Foils; Stimulated Raman Scattering in Large-Aperture, High-Fluence Frequency-Conversion Crystals; Fission Product Hazard Reduction Using Inertial Fusion Energy; Use of Inertial Confinement Fusion for Nuclear Weapons Effects Simulations.

  3. Information integration for data fusion

    SciTech Connect

    Bray, O.H.

    1997-01-01

    Data fusion has been identified by the Department of Defense as a critical technology for the U.S. defense industry. Data fusion requires combining expertise in two areas - sensors and information integration. Although data fusion is a rapidly growing area, there is little synergy and use of common, reusable, and/or tailorable objects and models, especially across different disciplines. The Laboratory-Directed Research and Development project had two purposes: to see if a natural language-based information modeling methodology could be used for data fusion problems, and if so, to determine whether this methodology would help identify commonalities across areas and achieve greater synergy. The project confirmed both of the initial hypotheses: that the natural language-based information modeling methodology could be used effectively in data fusion areas and that commonalities could be found that would allow synergy across various data fusion areas. The project found five common objects that are the basis for all of the data fusion areas examined: targets, behaviors, environments, signatures, and sensors. Many of the objects and the specific facts related to these objects were common across several areas and could easily be reused. In some cases, even the terminology remained the same. In other cases, different areas had their own terminology, but the concepts were the same. This commonality is important with the growing use of multisensor data fusion. Data fusion is much more difficult if each type of sensor uses its own objects and models rather than building on a common set. This report introduces data fusion, discusses how the synergy generated by this LDRD would have benefited an earlier successful project and contains a summary information model from that project, describes a preliminary management information model, and explains how information integration can facilitate cross-treaty synergy for various arms control treaties.

  4. LiWall Fusion - The New Concept of Magnetic Fusion

    SciTech Connect

    L.E. Zakharov

    2011-01-12

    Utilization of the outstanding abilities of a liquid lithium layer in pumping hydrogen isotopes leads to a new approach to magnetic fusion, called the LiWall Fusion. It relies on innovative plasma regimes with low edge density and high temperature. The approach combines fueling the plasma by neutral injection beams with the best possible elimination of outside neutral gas sources, which cools down the plasma edge. Prevention of cooling the plasma edge suppresses the dominant, temperature gradient related turbulence in the core. Such an approach is much more suitable for controlled fusion than the present practice, relying on high heating power for compensating essentially unlimited turbulent energy losses.

  5. Minimally invasive spine surgery in chronic low back pain patients.

    PubMed

    Spoor, A B; Öner, F C

    2013-09-01

    Low back pain (LBP) is a common disorder with a lifetime prevalence of 85%. The pathophysiology of LBP can be various depending on the underlying problem. Only in about 10% of the patients specific underlying disease processes can be identified. Patients with scoliosis, spondylolisthesis, herniated discs, adjacent disc disease, disc degeneration, failed back surgery syndrome or pseudoartrosis all have symptoms of LBP in different ways. Chronic low back pain patients are advised to stay active, however, there is no strong evidence that exercise therapy is significantly different than other nonsurgical therapies. Not every patient with symptoms of LBP is an appropriate candidate for surgery. Even with thorough systematic reviews, no proof can be found for the benefit of surgery in patients with low back pain, without serious neurologic deficit. And subjects like psychologic and socio-demographic factors also seem to be influencing a patients perception of back pain, expectations of treatment, and outcomes of treatment. Open lumbar fusion procedures are typically lengthy procedures and require a long exposure, which may result in ischemic necrosis of the paraspinal musculature, atrophy, and prolonged back pain. Minimally invasive spine surgery needed to take care of a decrease in muscle injuries due to retraction and avoidance of disruption of the osseotendineous complex of the paraspinal muscles, especially the multifidus attachment to the spinous process and superior articular process. Therefore, effort has been made to develop percutaneous fusion, as well as fixation methods, which avoid the negative effects of open surgery. Several minimally invasive fusion strategies have been described, like anterior lumbar interbody fusion (ALIF), posterior lumbar interbody fusion (PLIF), transforaminal lumbar interbody fusion (TLIF) and two lateral approaches (XLIF and DLIF), all with pro's and con's compared to open surgery and each other. The effect of MIS of all type is that patients have less blood loss, faster postoperative ambulation, lower use of opioids, and shorter in hospital stay, which is nearly always significantly better than an open procedure. And most of the studies show a significant improvement of VAS leg-and back pain, Oswestry Disability Index and a high fusion rate, but most of the times not significantly different than the open counterpart. When it comes to cost-effectiveness there is a trend in favor of MIS, but to when we want to differentiate MIS from open surgery, comorbidities and complications significantly affect general and disease-specific outcome measures. In our opinion, the actual better outcome of minimal invasive surgery comes down to obtain a good cost-effectiveness study, provided that minimally invasive surgery has an equal or better clinical and radiologic outcome, given that socio-economic, demographic and psychological influencers are equal for both types of surgery. There are no studies done on the subject MIS and low back pain solely. Deriving answers from the difference in VAS back pain in MIS studies reveal a 100% improvement of back pain after surgery. But that does not imply that this procedure, which is still in its childhood, will be the solution to all low back pain patients. PMID:23877267

  6. Poxvirus entry and membrane fusion

    SciTech Connect

    Moss, Bernard [Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0445 (United States)]. E-mail: bmoss@nih.gov

    2006-01-05

    The study of poxvirus entry and membrane fusion has been invigorated by new biochemical and microscopic findings that lead to the following conclusions: (1) the surface of the mature virion (MV), whether isolated from an infected cell or by disruption of the membrane wrapper of an extracellular virion, is comprised of a single lipid membrane embedded with non-glycosylated viral proteins; (2) the MV membrane fuses with the cell membrane, allowing the core to enter the cytoplasm and initiate gene expression; (3) fusion is mediated by a newly recognized group of viral protein components of the MV membrane, which are conserved in all members of the poxvirus family; (4) the latter MV entry/fusion proteins are required for cell to cell spread necessitating the disruption of the membrane wrapper of extracellular virions prior to fusion; and furthermore (5) the same group of MV entry/fusion proteins are required for virus-induced cell-cell fusion. Future research priorities include delineation of the roles of individual entry/fusion proteins and identification of cell receptors.

  7. Information fusion, application to data and model fusion for ultrasound image segmentation

    Microsoft Academic Search

    B. Solaiman; R. Debon; F. Pipelier; J.-M. Cauvin; C. Roux

    1999-01-01

    Nowadays, information fusion constitutes a challenging research topic. The authors' study proposes to achieve the fusion of several knowledge sources. This, in order to detect the esophagus inner wall from ultrasound medical images. After a brief description of information fusion concepts, the authors propose a system architecture including both model and data fusion. The data fusion is accomplished using fuzzy

  8. Detecting Sensor Failures in a Multi-Sensor Data Fusion SystemData Fusion System

    E-print Network

    Berns, Karsten

    Detecting Sensor Failures in a Multi-Sensor Data Fusion SystemData Fusion System Thomas Pfister 21 · Introduction · Realization sensor fusion · Failure detection methods · Simulation results Detecting Sensor Failures in a Multi-Sensor Data Fusion System #12;Introduction Multi-Sensor Data Fusion · Problem

  9. Optimal fusion estimation covariance of multisensor data fusion on tracking problem

    Microsoft Academic Search

    Jin Xue-bo; Sun You-xian

    2002-01-01

    A measurement fusion function is defined and shown to decide the covariance of measurement fusion. If two multisensor data fusion systems have identical measurement fusion function, then the systems have identical covariances. The greater the function is, the less covariance the fusion system can obtain.

  10. Improved Image Fusion Using Balanced Multiwavelets

    E-print Network

    Ghouti, Lahouari

    imaging, and military application, effective sensor/data fusion has received much attention be discarded. Image fusion can take place at the signal, pixel, feature, transform, and symbol level. FusionImproved Image Fusion Using Balanced Multiwavelets Lahouari Ghouti, Ahmed Bouridane and Mohammad K

  11. Medical imaging fusion applications: An overview

    Microsoft Academic Search

    S. P. Constantinos; Marios S. Pattichis; Evangelia Micheli-Tzanakou

    2001-01-01

    Computer aided fusion of multi-modality medical images provides a very promising diagnostic tool with numerous clinical applications. The objective of this paper is to present an overview of medical imaging fusion techniques with an emphasis on the use of neural network algorithms. Case studies derived from oncology (data level fusion), microscopy and ultrasound imaging (feature level and decision level fusion),

  12. Class II virus membrane fusion proteins

    Microsoft Academic Search

    Margaret Kielian

    2006-01-01

    Enveloped animal viruses fuse their membrane with a host cell membrane, thus delivering the virus genetic material into the cytoplasm and initiating infection. This critical membrane fusion reaction is mediated by a virus transmembrane protein known as the fusion protein, which inserts its hydrophobic fusion peptide into the cell membrane and refolds to drive the fusion reaction. This review describes

  13. Fusion Development Path Panel Preliminary Report

    E-print Network

    Fusion Development Path Panel Preliminary Report Summary for NRC BPAC Panel (Focus on MFE of a demonstration power plant in approximately 35 years. The plan should recognize the capabilities of all fusion facilities around the world, and include both magnetic fusion energy (MFE) and inertial fusion energy (IFE

  14. 2002 Fusion Summer Study Executive Summary

    E-print Network

    2002 Fusion Summer Study Executive Summary 31 July 2002 #12;page 2 of 15 2002 Fusion Summer Study Executive Summary The 2002 Fusion Summer Study was conducted from July 8-19, 2002, in Snowmass, CO, and carried out a critical assessment of major next-steps in the fusion energy sciences program in both

  15. Technical issues in fusion reactors; A review

    Microsoft Academic Search

    V. K. Rohatgi; T. Vijayan

    1989-01-01

    In this paper the issues in fusion reactor technology are examined. Rapid progress in fusion technology research in recent years can be attributed to the advances in various technologies. The commercial generation of fusion power greatly depends on the evolution and improvements in these technologies. With better understanding of plasma physics, fusion reactor designs are becoming more and more realistic

  16. Fusion Energy: Visions of the Future

    E-print Network

    Scale, Terrapower, Areva Nat'l Ignition Facility, Iter, General Fusion TriAlpha, Polywell, LPP #12;DeuteriumFusion Energy: Visions of the Future Dec. 10-11, 2013 FOCUS FUSION Cheap, Clean, Safe & Unlimited Energy #12;Controlled Nuclear Fusion With a Dense Plasma Focus Device Running on Aneutronic Fuel What

  17. Information Representation for Image Fusion Evaluation

    Microsoft Academic Search

    V. Petrovic; T. Cootes

    2006-01-01

    The considerable number of image fusion algorithms available today vary widely in terms of fusion performance and robust fusion assessment tools have become a target of considerable research. Based on a variety of localised or global evaluations of image statistics and structure between the inputs and the fused image, available objective fusion evaluation metrics use a number of different information

  18. Image Fusion: Principles, Methods, and Applications

    E-print Network

    Sroubek, Filip

    In this tutorial we categorize the IF methods according to the data entering the fusion and according to the fusionImage Fusion: Principles, Methods, and Applications Tutorial EUSIPCO 2007 Lecture Notes Jan Flusser in several domains. The goal of image fusion (IF) is to integrate complementary multisensor, multitemporal

  19. EDITORIAL: Safety aspects of fusion power plants

    Microsoft Academic Search

    B. N. Kolbasov

    2007-01-01

    This special issue of Nuclear Fusion contains 13 informative papers that were initially presented at the 8th IAEA Technical Meeting on Fusion Power Plant Safety held in Vienna, Austria, 10-13 July 2006. Following recommendation from the International Fusion Research Council, the IAEA organizes Technical Meetings on Fusion Safety with the aim to bring together experts to discuss the ongoing work,

  20. Safety aspects of fusion power plants

    Microsoft Academic Search

    B. N. Kolbasov

    2007-01-01

    This special issue of Nuclear Fusion contains 13 informative papers that were initially presented at the 8th IAEA Technical Meeting on Fusion Power Plant Safety held in Vienna, Austria, 10–13 July 2006.Following recommendation from the International Fusion Research Council, the IAEA organizes Technical Meetings on Fusion Safety with the aim to bring together experts to discuss the ongoing work, share

  1. Driven Reconnection in Magnetic Fusion Experiments

    E-print Network

    Fitzpatrick, Richard

    Driven Reconnection in Magnetic Fusion Experiments Richard Fitzpatrick Institute for Fusion Studies of life in magnetic fusion experiments. What effects do error fields have on plasma confinement? How can be sufficiently high (i.e. B > 1 tesla) that the Lamor radii of 3.5 M eV fusion product alpha particles are small

  2. Fusion Power Demonstration III

    SciTech Connect

    Lee, J.D. (ed.)

    1985-07-01

    This is the third in the series of reports covering the Fusion Power Demonstration (FPD) design study. This volume considers the FPD-III configuration that incorporates an octopole end plug. As compared with the quadrupole end-plugged designs of FPD-I and FPD-II, this octopole configuration reduces the number of end cell magnets and shortens the minimum ignition length of the central cell. The end-cell plasma length is also reduced, which in turn reduces the size and cost of the end cell magnets and shielding. As a contiuation in the series of documents covering the FPD, this report does not stand alone as a design description of FPD-III. Design details of FPD-III subsystems that do not differ significantly from those of the FPD-II configuration are not duplicated in this report.

  3. Fusion pumped laser

    DOEpatents

    Pappas, Daniel S. (Los Alamos, NM)

    1989-01-01

    Apparatus is provided for generating energy in the form of laser radiation. A tokamak fusion reactor is provided for generating a long, or continuous, pulse of high-energy neutrons. The tokamak design provides a temperature and a magnetic field which is effective to generate a neutron flux of at least 10.sup.15 neutrons/cm.sup.2.s. A conversion medium receives neutrons from the tokamak and converts the high-energy neutrons to an energy source with an intensity and an energy effective to excite a preselected lasing medium. The energy source typically comprises fission fragments, alpha particles, and radiation from a fission event. A lasing medium is provided which is responsive to the energy source to generate a population inversion which is effective to support laser oscillations for generating output radiation.

  4. Cosmic Data Fusion

    NASA Astrophysics Data System (ADS)

    Bridle, S. L.

    I will discuss our work on cosmic data fusion: the comparison and combination of various cosmological data sets to estimate cosmological parameters. We find good agreement on cosmological parameters between galaxy velocities, CMB and Type 1a supernovae with 95 per cent confidence limits 0.64 < h < 0.86, 0.17 < &Omegam < 0.39 and 0.98 < ?8 < 1.37. We also find agreement in the ?m, h, ?8 parameter space between cluster number counts, CMB and the IRAS galaxy redshift survey, with similar constraints on ?m but slightly lower values for h and significantly higher values for ?8. References: Bridle, Eke, Lahav, Lasenby, Hobson, Cole, Frenk, and Henry, 1999, MNRAS, 310, 565 Bridle, Zehavi, Dekel, Lahav, Hobson and Lasenby, MNRAS, submitted (astro-ph/0006170)

  5. Microwave superheaters for fusion

    SciTech Connect

    Campbell, R.B.; Hoffman, M.A.; Logan, B.G.

    1987-10-16

    The microwave superheater uses the synchrotron radiation from a thermonuclear plasma to heat gas seeded with an alkali metal to temperatures far above the temperature of material walls. It can improve the efficiency of the Compact Fusion Advanced Rankine (CFAR) cycle described elsewhere in these proceedings. For a proof-of-principle experiment using helium, calculations show that a gas superheat ..delta..T of 2000/sup 0/K is possible when the wall temperature is maintained at 1000/sup 0/K. The concept can be scaled to reactor grade systems. Because of the need for synchrotron radiation, the microwave superheater is best suited for use with plasmas burning an advanced fuel such as D-/sup 3/He. 5 refs.

  6. Fusion reactor pumped laser

    DOEpatents

    Jassby, D.L.

    1987-09-04

    A nuclear pumped laser capable of producing long pulses of very high power laser radiation is provided. A toroidal fusion reactor provides energetic neutrons which are slowed down by a moderator. The moderated neutrons are converted to energetic particles capable of pumping a lasing medium. The lasing medium is housed in an annular cell surrounding the reactor. The cell includes an annular reflecting mirror at the bottom and an annular output window at the top. A neutron reflector is disposed around the cell to reflect escaping neutrons back into the cell. The laser radiation from the annular window is focused onto a beam compactor which generates a single coherent output laser beam. 10 figs.

  7. Muon catalyzed fusion

    SciTech Connect

    Breunlich, W.H.; Cargnelli, M.; Marton, J.; Naegele, N.; Pawlek, P.; Scrinzi, A.; Werner, J.; Zmeskal, J.; Bistirlich, J.; Crowe, K.M.

    1986-01-01

    This paper presents an overview of the program and results of our experiment performed by a European-American collatoration at the Swiss Institute of Nuclear Research. Systematic investigations of the low temperature region (23K to 300K) reveal a surprisingly rich physics of mesoatomic and mesomolecular processes, unparalleled in other systems of isotopic hydrogen mixtures. A dramatic density dependence of the reaction rates is found. The rich structure in the time spectra of the fusion neutrons observed at low gas density yields first evidence for new effects, most likely strong contributions from reactions of hot muonic atoms. The important question of muon losses due to He sticking is investigated by different methods and over a wide range of tritium concentrations.

  8. Soldier systems sensor fusion

    NASA Astrophysics Data System (ADS)

    Brubaker, Kathryne M.

    1998-08-01

    This paper addresses sensor fusion and its applications in emerging Soldier Systems integration and the unique challenges associated with the human platform. Technology that,provides the highest operational payoff in a lightweight warrior system must not only have enhanced capabilities, but have low power components resulting in order of magnitude reductions coupled with significant cost reductions. These reductions in power and cost will be achieved through partnership with industry and leveraging of commercial state of the art advancements in microelectronics and power sources. As new generation of full solution fire control systems (to include temperature, wind and range sensors) and target acquisition systems will accompany a new generation of individual combat weapons and upgrade existing weapon systems. Advanced lightweight thermal, IR, laser and video senors will be used for surveillance, target acquisition, imaging and combat identification applications. Multifunctional sensors will provide embedded training features in combat configurations allowing the soldier to 'train as he fights' without the traditional cost and weight penalties associated with separate systems. Personal status monitors (detecting pulse, respiration rate, muscle fatigue, core temperature, etc.) will provide commanders and highest echelons instantaneous medical data. Seamless integration of GPS and dead reckoning (compass and pedometer) and/or inertial sensors will aid navigation and increase position accuracy. Improved sensors and processing capability will provide earlier detection of battlefield hazards such as mines, enemy lasers and NBC (nuclear, biological, chemical) agents. Via the digitized network the situational awareness database will automatically be updated with weapon, medical, position and battlefield hazard data. Soldier Systems Sensor Fusion will ultimately establish each individual soldier as an individual sensor on the battlefield.

  9. Advanced fusion concepts: project summaries

    SciTech Connect

    None

    1980-12-01

    This report contains descriptions of the activities of all the projects supported by the Advanced Fusion Concepts Branch of the Office of Fusion Energy, US Department of Energy. These descriptions are project summaries of each of the individual projects, and contain the following: title, principle investigators, funding levels, purpose, approach, progress, plans, milestones, graduate students, graduates, other professional staff, and recent publications. Information is given for each of the following programs: (1) reverse-field pinch, (2) compact toroid, (3) alternate fuel/multipoles, (4) stellarator/torsatron, (5) linear magnetic fusion, (6) liners, and (7) Tormac. (MOW)

  10. Development of inertial fusion energy

    SciTech Connect

    Nakai, S.; Mima, K.; Kitagawa, Y.; Sakabe, S.; Izawa, Y.; Nakatsuka, M.; Yamanaka, M.; Fujita, H.; Jitsuno, T.; Kanabe, T.; Miyanaga, N.; Tsubakimoto, K.; Motokoshi, S.; Kiriyama, H.; Matsui, H.; Takabe, H.; Norimatsu, T.; Takagi, M.; Kozaki, Y.; Yamanaka, T. [Institute of Laser Engineering, Osaka University, 2-6 Yamadaoka, Suita, Osaka 565 (Japan)] (and others)

    1997-04-15

    The long term strategy of Inertial Fusion Energy(IFE) development has reexamined being based on the conceptual design study of laser fusion power plant KOYO, and taking into account the recent progresses of implosion physics research and the reactor related technologies. The design study and the strategy analysis have been conducted as a joint program of university, national laboratory and industries in Japan, and also with international collaborations. It is concluded that the feasibility of inertial fusion power plant is reasonably high and the coordinated R and D throughout the world would be effective.

  11. Pubertal growth and epiphyseal fusion

    PubMed Central

    2015-01-01

    The complex networks of nutritional, cellular, paracrine, and endocrine factors are closely related with pubertal growth and epiphyseal fusion. Important influencing factors include chondrocyte differentiation capacity, multiple molecular pathways active in the growth plate, and growth hormone-insulin-like growth factor-I axis activation and epiphyseal fusion through estrogen and its receptors. However, the exact mechanisms of these phenomena are still unclear. A better understanding of the detailed processes involved in the pubertal growth spurt and growth plate closure in longitudinal bone growth will help us develop methods to efficiently promote pubertal growth and delay epiphyseal fusion with fewer adverse effects. PMID:25883921

  12. Fusion materials irradiations at MaRIE's fission fusion facility

    SciTech Connect

    Pitcher, Eric J [Los Alamos National Laboratory

    2010-10-06

    Los Alamos National Laboratory's proposed signature facility, MaRIE, will provide scientists and engineers with new capabilities for modeling, synthesizing, examining, and testing materials of the future that will enhance the USA's energy security and national security. In the area of fusion power, the development of new structural alloys with better tolerance to the harsh radiation environments expected in fusion reactors will lead to improved safety and lower operating costs. The Fission and Fusion Materials Facility (F{sup 3}), one of three pillars of the proposed MaRIE facility, will offer researchers unprecedented access to a neutron radiation environment so that the effects of radiation damage on materials can be measured in-situ, during irradiation. The calculated radiation damage conditions within the F{sup 3} match, in many respects, that of a fusion reactor first wall, making it well suited for testing fusion materials. Here we report in particular on two important characteristics of the radiation environment with relevancy to radiation damage: the primary knock-on atom spectrum and the impact of the pulse structure of the proton beam on temporal characteristics of the atomic displacement rate. With respect to both of these, analyses show the F{sup 3} has conditions that are consistent with those of a steady-state fusion reactor first wall.

  13. Pulsed Power Driven Fusion Energy

    SciTech Connect

    SLUTZ,STEPHEN A.

    1999-11-22

    Pulsed power is a robust and inexpensive technology for obtaining high powers. Considerable progress has been made on developing light ion beams as a means of transporting this power to inertial fusion capsules. However, further progress is hampered by the lack of an adequate ion source. Alternatively, z-pinches can efficiently convert pulsed power into thermal radiation, which can be used to drive an inertial fusion capsule. However, a z-pinch driven fusion explosion will destroy a portion of the transmission line that delivers the electrical power to the z-pinch. They investigate several options for providing standoff for z-pinch driven fusion. Recyclable Transmission Lines (RTLs) appear to be the most promising approach.

  14. U. S. Fusion Energy Future

    SciTech Connect

    John A. Schmidt; Dan Jassby; Scott Larson; Maria Pueyo; Paul H. Rutherford

    2000-10-12

    Fusion implementation scenarios for the US have been developed. The dependence of these scenarios on both the fusion development and implementation paths has been assessed. A range of implementation paths has been studied. The deployment of CANDU fission reactors in Canada and the deployment of fission reactors in France have been assessed as possible models for US fusion deployment. The waste production and resource (including tritium) needs have been assessed. The conclusion that can be drawn from these studies is that it is challenging to make a significant impact on energy production during this century. However, the rapid deployment of fission reactors in Canada and France support fusion implementation scenarios for the US with significant power production during this century. If the country can meet the schedule requirements then the resource needs and waste production are found to be manageable problems.

  15. ../fusion/templates/mapguide/maroon/css/maroon_fusion.css background-image: url(../images/background.gif);

    E-print Network

    Ahmad, Sajjad

    ../fusion/templates/mapguide/maroon/css/maroon_fusion.css body { background-image: url(../images/background.gif); ../fusion/templates/mapguide/maroon/css/ maroon_fusion.css body { background-color: #3e5c5f; ../fusion/templates/mapguide/maroon/css/ maroon_fusion.css #ToolbarVertical { background: #500000; maroon_fusion.css #Toolbar { background

  16. Advanced materials for fusion energy

    Microsoft Academic Search

    Steven J. Zinkle; A. Kohyama

    2002-01-01

    An overview is given regarding recent work on the development of advanced structural and nonstructural materials for fusion reactors. In particular, research highlights are presented on advanced ferritic\\/martensitic steels, V alloys, Mo alloys, and SiC composites, which are candidate structural materials for fusion systems. The potential for developing improved high-strength, high-conductivity Cu alloys for normal conducting magnets and divertor structures

  17. Laser fusion monthly -- August 1980

    SciTech Connect

    Ahlstrom, H.G. [ed.

    1980-08-01

    This report documents the monthly progress for the laser fusion research at Lawrence Livermore National Laboratory. First it gives facilities report for both the Shiva and Argus projects. Topics discussed include; laser system for the Nova Project; the fusion experiments analysis facility; optical/x-ray streak camera; Shiva Dante System temporal response; 2{omega}{sub 0} experiment; and planning for an ICF engineering test facility.

  18. Data fusion with minimal communication

    Microsoft Academic Search

    Zhi-quan Luo; John N. Tsitsiklis

    1994-01-01

    Two sensors obtain data vectors x and y, respectively, and transmit real vectors m&oarr;1(x) and m&oarr;2(y), respectively, to a fusion center. The authors obtain tight lower bounds on the number of messages (the sum of the dimensions of m&oarr;1 and m&oarr;2) that have to be transmitted for the fusion center to be able to evaluate a given function f&oarr;(x,y). When

  19. Fusion Nuclear Science Facility (FNSF)

    Microsoft Academic Search

    Y. K. M. Peng; J. M. Park; J. M. Canik; S. J. Diem; A. C. Sontag; A. Lumsdaine; Yl Katoh; R. W. Burgess; K. Korsah; B. D. Patton; J. C. Wagner; P. J. Fogarty; M. Sawan

    2011-01-01

    A compact (Ro-1.2-1.3m), low aspect ratio, low-Q «3) Fusion Nuclear Science Facility (FNSF) was recently assessed to provide a fully integrated, D-T-fueled, continuously driven plasma, volumetric nuclear environment of copious neutrons. This environment would be used, for the first time, to carry out discovery-driven research in fusion nuclear science and materials, in parallel with and complementary to ITER. This research

  20. Magnetic fusion 1985: what next

    SciTech Connect

    Fowler, T.K.

    1985-03-01

    Recent budget reductions for magnetic fusion have led to a re-examination of program schedules and objectives. Faced with delays and postponement of major facilities as previously planned, some have called for a near-term focus on science, others have stressed technology. This talk will suggest a different focus as the keynote for this conference, namely, the applications of fusion. There is no doubt that plasma science is by now mature and fusion technology is at the forefront. This has and will continue to benefit many fields of endeavor, both in actual new discoveries and techniques and in attracting and training scientists and engineers who move on to make significant contributions in science, defense and industry. Nonetheless, however superb the science or how challenging the technology, these are means, not ends. To maintain its support, the magnetic fusion program must also offer the promise of power reactors that could be competitive in the future. At this conference, several new reactor designs will be described that claim to be smaller and economically competitive with fission reactors while retaining the environmental and safety characteristics that are the hallmark of fusion. The American Nuclear Society is an appropriate forum in which to examine these new designs critically, and to stimulate better ideas and improvements. As a preview, this talk will include brief discussions of new tokamak, tandem mirror and reversed field pinch reactor designs to be presented in later sessions. Finally, as a preview of the session on fusion breeders, the talk will explore once again the economic implications of a new nuclear age, beginning with improved fission reactors fueled by fusion breeders, then ultimately evolving to reactors based solely on fusion.

  1. Prospects for improved fusion reactors

    SciTech Connect

    Krakowski, R.A.; Miller, R.L.; Hagenson, R.L.

    1986-01-01

    Ideally, a new energy source must be capable of displacing old energy sources while providing both economic opportunities and enhanced environmental benefits. The attraction of an essentially unlimited fuel supply has generated a strong impetus to develop advanced fission breeders and, even more strongly, the exploitation of nuclear fusion. Both fission and fusion systems trade a reduced fuel charge for a more capital-intensive plant needed to utilize a cheaper and more abundant fuel. Results from early conceptual designs of fusion power plants, however, indicated a capital intensiveness that could override cost savings promised by an inexpensive fuel cycle. Early warnings of these problems appeared, and generalized routes to more economically attractive systems have been suggested; specific examples have also recently been given. Although a direct reduction in the cost (and mass) of the fusion power core (FPC, i.e., plasma chamber, first wall, blanket, shield, coils, and primary structure) most directly reduces the overall cost of fusion power, with the mass power density (MPD, ratio of net electric power to FPC mass, kWe/tonne) being suggested as a figure-of-merit in this respect, other technical, safety/environmental, and institutional issues also enter into the definition of and direction for improved fusion concepts. These latter issues and related tradeoffs are discussed.

  2. Prospects for Tokamak Fusion Reactors

    SciTech Connect

    Sheffield, J.; Galambos, J.

    1995-04-01

    This paper first reviews briefly the status and plans for research in magnetic fusion energy and discusses the prospects for the tokamak magnetic configuration to be the basis for a fusion power plant. Good progress has been made in achieving fusion reactor-level, deuterium-tritium (D-T) plasmas with the production of significant fusion power in the Joint European Torus (up to 2 MW) and the Tokamak Fusion Test Reactor (up to 10 MW) tokamaks. Advances on the technologies of heating, fueling, diagnostics, and materials supported these achievements. The successes have led to the initiation of the design phases of two tokamaks, the International Thermonuclear Experimental Reactor (ITER) and the US Toroidal Physics Experiment (TPX). ITER will demonstrate the controlled ignition and extended bum of D-T plasmas with steady state as an ultimate goal. ITER will further demonstrate technologies essential to a power plant in an integrated system and perform integrated testing of the high heat flux and nuclear components required to use fusion energy for practical purposes. TPX will complement ITER by testing advanced modes of steady-state plasma operation that, coupled with the developments in ITER, will lead to an optimized demonstration power plant.

  3. Robust Match Fusion Using Optimization.

    PubMed

    Qin, Xiameng; Shen, Jianbing; Mao, Xiaoyang; Li, Xuelong; Jia, Yunde

    2015-08-01

    In this paper, we present a novel patch-based match and fusion algorithm by taking account of moving scene in a multiple exposure image sequence using optimization. A uniform iterative approach is developed to match and find the corresponding patches in different exposure images, which are then fused in each iteration. Our approach does not need to align the input multiple exposure images before the fusion process. Considering that the pixel values are affected by various exposure time, we design a new patch-based energy function that will be optimized to improve the matching accuracy. An efficient patch-based exposure fusion approach using the random walker algorithm is developed to preserve the moving objects from the input multiple exposure images. To the best of our knowledge, our algorithm is the first patch-based exposure fusion work to preserve the moving objects of dynamic scenes that does not need the registration process of different exposure images. Experimental results of moving scenes demonstrate that our algorithm achieves visually pleasing fusion results without ghosting artifacts, while the results produced by the state-of-the-art exposure fusion and tone mapping algorithms exhibit different levels of ghosting artifacts. PMID:25248209

  4. The scientific status of fusion

    NASA Astrophysics Data System (ADS)

    Crandall, D. H.

    1989-07-01

    The development of fusion energy has been a large-scale scientific undertaking of broad interest. The magnetic plasma containment in tokamaks and the laser-drive ignition of microfusion capsules appear to be scientifically feasible sources of energy. These concepts are bounded by questions of required intensity in magnetic field and plasma currents or in drive energy and, for both concepts, by issues of plasma stability and energy transport. The basic concept and the current scientific issues are described for magnetic fusion and for the interesting, but likely infeasible, muon-catalyzed fusion concept. Inertial fusion is mentioned, qualitatively, to complete the context. Fusion appears to release energy in rather large quantities (about 1000 MW) and significant new devices are needed to make progress. For magnetic fusion, the required net energy production within the plasma may be accomplished soon, but the more useful goal of self-sustained plasma ignition requires a new device of somewhat uncertain (factor of 2) cost and size.

  5. TRITIUM ACCOUNTANCY IN FUSION SYSTEMS

    SciTech Connect

    Klein, J. E.; Farmer, D. A.; Moore, M. L.; Tovo, L. L.; Poore, A. S.; Clark, E. A.; Harvel, C. D.

    2014-03-06

    The US Department of Energy (DOE) has clearly defined requirements for nuclear material control and accountability (MC&A) of tritium whereas the International Atomic Energy Agency (IAEA) does not since tritium is not a fissile material. MC&A requirements are expected for tritium fusion machines and will be dictated by the host country or regulatory body where the machine is operated. Material Balance Areas (MBAs) are defined to aid in the tracking and reporting of nuclear material movements and inventories. Material subaccounts (MSAs) are established along with key measurement points (KMPs) to further subdivide a MBA to localize and minimize uncertainties in the inventory difference (ID) calculations for tritium accountancy. Fusion systems try to minimize tritium inventory which may require continuous movement of material through the MSAs. The ability of making meaningful measurements of these material transfers is described in terms of establishing the MSA structure to perform and reconcile ID calculations. For fusion machines, changes to the traditional ID equation will be discussed which includes breading, burn-up, and retention of tritium in the fusion device. The concept of “net” tritium quantities consumed or lost in fusion devices is described in terms of inventory taking strategies and how it is used to track the accumulation of tritium in components or fusion machines.

  6. Conformal nets III: fusion of defects

    E-print Network

    Arthur Bartels; Christopher L. Douglas; André Henriques

    2015-02-21

    Conformal nets provides a mathematical model for conformal field theory. We define a notion of defect between conformal nets, formalizing the idea of an interaction between two conformal field theories. We introduce an operation of fusion of defects, and prove that the fusion of two defects is again a defect, provided the fusion occurs over a conformal net of finite index. There is a notion of sector (or bimodule) between two defects, and operations of horizontal and vertical fusion of such sectors. Our most difficult technical result is that the horizontal fusion of the vacuum sectors of two defects is isomorphic to the vacuum sector of the fused defect. Equipped with this isomorphism, we construct the basic interchange isomorphism between the horizontal fusion of two vertical fusions and the vertical fusion of two horizontal fusions of sectors.

  7. Ultrastructural Analysis of Myoblast Fusion in Drosophila

    PubMed Central

    Zhang, Shiliang; Chen, Elizabeth H.

    2015-01-01

    Summary Myoblast fusion in Drosophila has become a powerful genetic system with which to unravel the mechanisms underlying cell fusion. The identification of important components of myoblast fusion by genetic analysis has led to a molecular pathway toward our understanding of this cellular process. In addition to the application of immunohistochemistry and live imaging techniques to visualize myoblast fusion at the light microscopic level, ultrastructural analysis using electron microscopy remains an indispensable tool to reveal fusion intermediates and specific membrane events at sites of fusion. In this chapter, we describe conventional chemical fixation and high-pressure freezing/freeze substitution methods for visualizing fusion intermediates during Drosophila myoblast fusion. Furthermore, we describe an immunoelectron microscopic method for localizing specific proteins relative to the fusion apparatus. PMID:18979250

  8. Heavy ion fusion sources

    SciTech Connect

    Grote, D.P.; Kwan, J.; Westenskow, G.

    2003-02-01

    In Heavy-Fusion and in other applications, there is a need for high brightness sources with both high current and low emittance. The traditional design with a single monolithic source, while very successful, has significant constraints on it when going to higher currents. With the Child-Langmuir current-density limit, geometric aberration limits, and voltage breakdown limits, the area of the source becomes a high power of the current, A {approx} I{sup 8/3}. We are examining a multi-beamlet source, avoiding the constraints by having many beamlets each with low current and small area. The beamlets are created and initially accelerated separately and then merged to form a single beam. This design offers a number of potential advantages over a monolithic source, such as a smaller transverse footprint, more control over the shaping and aiming of the beam, and more flexibility in the choice of ion sources. A potential drawback, however, is the emittance that results from the merging of the beamlets. We have designed injectors using simulation that have acceptably low emittance and are beginning to examine them experimentally.

  9. Fusion plasma theory project summaries

    NASA Astrophysics Data System (ADS)

    1993-10-01

    This Project Summary book is a published compilation consisting of short descriptions of each project supported by the Fusion Plasma Theory and Computing Group of the Advanced Physics and Technology Division of the Department of Energy, Office of Fusion Energy. The summaries contained in this volume were written by the individual contractors with minimal editing by the Office of Fusion Energy. Previous summaries were published in February of 1982 and December of 1987. The Plasma Theory program is responsible for the development of concepts and models that describe and predict the behavior of a magnetically confined plasma. Emphasis is given to the modelling and understanding of the processes controlling transport of energy and particles in a toroidal plasma and supporting the design of the International Thermonuclear Experimental Reactor (ITER). A tokamak transport initiative was begun in 1989 to improve understanding of how energy and particles are lost from the plasma by mechanisms that transport them across field lines. The Plasma Theory program has actively participated in this initiative. Recently, increased attention has been given to issues of importance to the proposed Tokamak Physics Experiment (TPX). Particular attention has been paid to containment and thermalization of fast alpha particles produced in a burning fusion plasma as well as control of sawteeth, current drive, impurity control, and design of improved auxiliary heating. In addition, general models of plasma behavior are developed from physics features common to different confinement geometries. This work uses both analytical and numerical techniques. The Fusion Theory program supports research projects at U.S. government laboratories, universities and industrial contractors. Its support of theoretical work at universities contributes to the office of Fusion Energy mission of training scientific manpower for the U.S. Fusion Energy Program.

  10. HEDP and new directions for fusion energy

    NASA Astrophysics Data System (ADS)

    Kirkpatrick, Ronald C.

    2010-06-01

    Magnetic-confinement fusion energy and inertia-confinement fusion energy (IFE) represent two extreme approaches to the quest for the application of thermonuclear fusion to electrical energy generation. Blind pursuit of these extreme approaches has long delayed the achievement of their common goal. We point out the possibility of an intermediate approach that promises cheaper, and consequently more rapid development of fusion energy. For example, magneto-inertial fusion appears to be possible over a broad range of parameter space. It is further argued that imposition of artificial constraints impedes the discovery of physics solutions for the fusion energy problem.

  11. FUSION SCIENCE CENTER FOR EXTREME STATES OF MATTER

    E-print Network

    FUSION SCIENCE CENTER FOR EXTREME STATES OF MATTER Fusion Power Associates Meeting, December 14 #12;TOPICS: Implosion hydrodynamics Laser-matter interaction Radiation transport Inertial confinement fusion Material properties at extreme conditions 12 LECTURERS SPONSORS: Fusion Science Center ILSA

  12. Fusion or confusion: knowledge or nonsense?

    NASA Astrophysics Data System (ADS)

    Rothman, Peter L.; Denton, Richard V.

    1991-08-01

    The terms 'data fusion,' 'sensor fusion,' multi-sensor integration,' and 'multi-source integration' have been used widely in the technical literature to refer to a variety of techniques, technologies, systems, and applications which employ and/or combine data derived from multiple information sources. Applications of data fusion range from real-time fusion of sensor information for the navigation of mobile robots to the off-line fusion of both human and technical strategic intelligence data. The Department of Defense Critical Technologies Plan lists data fusion in the highest priority group of critical technologies, but just what is data fusion? The DoD Critical Technologies Plan states that data fusion involves 'the acquisition, integration, filtering, correlation, and synthesis of useful data from diverse sources for the purposes of situation/environment assessment, planning, detecting, verifying, diagnosing problems, aiding tactical and strategic decisions, and improving system performance and utility.' More simply states, sensor fusion refers to the combination of data from multiple sources to provide enhanced information quality and availability over that which is available from any individual source alone. This paper presents a survey of the state-of-the- art in data fusion technologies, system components, and applications. A set of characteristics which can be utilized to classify data fusion systems is presented. Additionally, a unifying mathematical and conceptual framework within which to understand and organize fusion technologies is described. A discussion of often overlooked issues in the development of sensor fusion systems is also presented.

  13. Adaptive multistrategy image fusion method

    NASA Astrophysics Data System (ADS)

    Luo, Xiao-qing; Zhang, Zhan-cheng; Wu, Xiao-jun

    2014-09-01

    Design of fusion rule is an important step in fusion process. Traditional single fusion rules are inflexible when they are being used to fuse feature-rich images. To address this problem, an adaptive multistrategy image fusion method is proposed. Its flexibility lies in the combination of a choose-max strategy and a weighted average strategy. Moreover, the region-based characteristics and the shift-invariant shearlet transform (SIST)-based activity measures are proposed to guide the selection of strategies. The key points of our method are: (1) Window-based features are extracted from the source images. (2) Use of the fuzzy c-means clustering algorithm to construct a region map in the feature difference space. (3) The dissimilarity between corresponding regions is employed to quantify the characteristic of regions and the local average variance of the SIST coefficients are considered as activity measures to evaluate the salience of the related coefficient. (4) The adaptive multistrategy selection scheme is achieved by a sigmoid function. Experimental results show that the proposed method is superior to the conventional image fusion methods both in subjective and objective evaluations.

  14. A Model for Membrane Fusion

    NASA Astrophysics Data System (ADS)

    Ngatchou, Annita

    2010-01-01

    Pheochromocytoma is a tumor of the adrenal gland which originates from chromaffin cells and is characterized by the secretion of excessive amounts of neurotransmitter which lead to high blood pressure and palpitations. Pheochromocytoma contain membrane bound granules that store neurotransmitter. The release of these stored molecules into the extracellular space occurs by fusion of the granule membrane with the cell plasma membrane, a process called exocytosis. The molecular mechanism of this membrane fusion is not well understood. It is proposed that the so called SNARE proteins [1] are the pillar of vesicle fusion as their cleavage by clostridial toxin notably, Botulinum neurotoxin and Tetanus toxin abrogate the secretion of neurotransmitter [2]. Here, I describe how physical principles are applied to a biological cell to explore the role of the vesicle SNARE protein synaptobrevin-2 in easing granule fusion. The data presented here suggest a paradigm according to which the movement of the C-terminal of synaptobrevin-2 disrupts the lipid bilayer to form a fusion pore through which molecules can exit.

  15. Nuclear Fusion prize laudation Nuclear Fusion prize laudation

    NASA Astrophysics Data System (ADS)

    Burkart, W.

    2011-01-01

    Clean energy in abundance will be of critical importance to the pursuit of world peace and development. As part of the IAEA's activities to facilitate the dissemination of fusion related science and technology, the journal Nuclear Fusion is intended to contribute to the realization of such energy from fusion. In 2010, we celebrated the 50th anniversary of the IAEA journal. The excellence of research published in the journal is attested to by its high citation index. The IAEA recognizes excellence by means of an annual prize awarded to the authors of papers judged to have made the greatest impact. On the occasion of the 2010 IAEA Fusion Energy Conference in Daejeon, Republic of Korea at the welcome dinner hosted by the city of Daejeon, we celebrated the achievements of the 2009 and 2010 Nuclear Fusion prize winners. Steve Sabbagh, from the Department of Applied Physics and Applied Mathematics, Columbia University, New York is the winner of the 2009 award for his paper: 'Resistive wall stabilized operation in rotating high beta NSTX plasmas' [1]. This is a landmark paper which reports record parameters of beta in a large spherical torus plasma and presents a thorough investigation of the physics of resistive wall mode (RWM) instability. The paper makes a significant contribution to the critical topic of RWM stabilization. John Rice, from the Plasma Science and Fusion Center, MIT, Cambridge is the winner of the 2010 award for his paper: 'Inter-machine comparison of intrinsic toroidal rotation in tokamaks' [2]. The 2010 award is for a seminal paper that analyzes results across a range of machines in order to develop a universal scaling that can be used to predict intrinsic rotation. This paper has already triggered a wealth of experimental and theoretical work. I congratulate both authors and their colleagues on these exceptional papers. W. Burkart Deputy Director General Department of Nuclear Sciences and Applications International Atomic Energy Agency, Vienna, Austria References [1] Sabbagh S. et al 2006 Nucl. Fusion 46 635-44 [2] Rice J.E. et al 2007 Nucl. Fusion 47 1618-24

  16. A Plan for the Development of Fusion Energy. Final Report to Fusion Energy Sciences Advisory Committee, Fusion Development Path Panel

    SciTech Connect

    none,

    2003-03-05

    This report presents a plan for the deployment of a fusion demonstration power plant within 35 years, leading to commercial application of fusion energy by mid-century. The plan is derived from the necessary features of a demonstration fusion power plant and from the time scale defined by President Bush. It identifies critical milestones, key decision points, needed major facilities and required budgets.

  17. Rapporteur talk for IAEA fusion meeting, Brussels

    SciTech Connect

    Watson, J.M.; Arnold, R.C.; Bogaty, J.M.

    1980-07-01

    A brief review of the following research topics is given: (1) accelerator drivers; (2) the Argonne heavy ion fusion program; (3) multimegajoule heavy-ion induction linacs; and (4) fusion applications of the Megalac. (MOW)

  18. Advanced Concepts: Aneutronic Fusion Power and Propulsion

    NASA Technical Reports Server (NTRS)

    Chapman, John J.

    2012-01-01

    Aneutronic Fusion for In-Space thrust, power. Clean energy & potential nuclear gains. Fusion plant concepts, potential to use advanced fuels. Methods to harness ionic momentum for high Isp thrust plus direct power conversion into electricity will be presented.

  19. What have fusion reactor studies done for you today

    Microsoft Academic Search

    Kulchinski

    1985-01-01

    The University of Wisconsin examines the fusion program and puts into perspective what return is being made on investments in fusion reactor studies. Illustations show financial support for fusion research from the four major programs, FY'82 expenditures on fusion research, and the total expenditures on fusion research since 1951. Topics discussed include the estimated number of scientists conducting fusion research,

  20. The Heavy Ion Fusion Virtual National Laboratory Status of Heavy Ion Fusion Science Program*

    E-print Network

    , theory and simulations to address a top-level scientific question central to both HEDP and fusion: How there is little or no data) (Courtesy of Dick Lee, LLNL) #12;The Heavy Ion Fusion Virtual National LaboratoryThe Heavy Ion Fusion Virtual National Laboratory Status of Heavy Ion Fusion Science Program* B

  1. Influenza Virus-Membrane Fusion Triggered by Proton Uncaging for Single Particle Studies of Fusion Kinetics

    E-print Network

    Daniel, Susan

    Influenza Virus-Membrane Fusion Triggered by Proton Uncaging for Single Particle Studies of Fusion for studying membrane fusion, focusing on influenza virus fusion to lipid bilayers, which provides high of material across membranes. For example, in virus infection, membrane-enveloped viruses, such as influenza

  2. 2002 Summer Fusion Study 1 July 19, 2002 2002 Fusion Summer Study

    E-print Network

    2002 Summer Fusion Study 1 July 19, 2002 2002 Fusion Summer Study Snowmass Village, CO. July 19, 2002 For Immediate Release Fusion energy shows great promise to contribute to securing the energy leading scientists from the U.S. and international fusion community concluded a two-week forum assessing

  3. FUSION-3792; No.of Pages15 Fusion Engineering and Design xxx (2006) xxxxxx

    E-print Network

    Raffray, A. René

    2006-01-01

    FUSION-3792; No.of Pages15 Fusion Engineering and Design xxx (2006) xxx­xxx Recent progress.07.087 #12;FUSION-3792; No.of Pages15 2 F. Najmabadi, A.R. Raffray / Fusion Engineering and Design xxx (2006) xxx­xxx of any stellarator configuration represents a large number of trade-offs among physics

  4. HIV-1 Fusion Peptide Decreases Bending Energy and Promotes Curved Fusion Intermediates

    E-print Network

    Nagle, John F.

    HIV-1 Fusion Peptide Decreases Bending Energy and Promotes Curved Fusion Intermediates Stephanie in human immunodeficiency virus (HIV) infection is fusion between the viral envelope and the T x-ray scattering is that the bending modulus KC is greatly reduced upon addition of the HIV fusion

  5. THE NATIONAL FUSION COLLABORATORY PROJECT: APPLYING GRID TECHNOLOGY FOR MAGNETIC FUSION RESEARCH

    E-print Network

    Thompson, Mary R.

    THE NATIONAL FUSION COLLABORATORY PROJECT: APPLYING GRID TECHNOLOGY FOR MAGNETIC FUSION RESEARCH D resources over the Internet. Some early prototype FusionGrid services proved so successful they are now used in a production environment for everyday fusion research. The success of other prototype services has resulted

  6. Superconducting magnets for fusion applications

    SciTech Connect

    Henning, C.D.

    1987-07-02

    Fusion magnet technology has made spectacular advances in the past decade; to wit, the Mirror Fusion Test Facility and the Large Coil Project. However, further advances are still required for advanced economical fusion reactors. Higher fields to 14 T and radiation-hardened superconductors and insulators will be necessary. Coupled with high rates of nuclear heating and pulsed losses, the next-generation magnets will need still higher current density, better stability and quench protection. Cable-in-conduit conductors coupled with polyimide insulations and better steels seem to be the appropriate path. Neutron fluences up to 10/sup 19/ neutrons/cm/sup 2/ in niobium tin are achievable. In the future, other amorphous superconductors could raise these limits further to extend reactor life or decrease the neutron shielding and corresponding reactor size.

  7. Laser fusion experiments at LLL

    SciTech Connect

    Ahlstrom, H.G.

    1980-06-16

    These notes present the experimental basis and status for laser fusion as developed at LLL. Two other chapters, one authored by K.A. Brueckner and the other by C. Max, present the theoretical implosion physics and laser plasma interaction physics. The notes consist of six sections. The first is an introductory section which provides some of the history of inertial fusion and a simple explanation of the concepts involved. The second section presents an extensive discussion of diagnostic instrumentation used in the LLL Laser Fusion Program. The third section is a presentation of laser facilities and capabilities at LLL. The purpose here is to define capability, not to derive how it was obtained. The fourth and fifth sections present the experimental data on laser-plasma interaction and implosion physics. The last chapter is a short projection of the future.

  8. Fusion, Fission, and Membrane Microdomains

    NASA Astrophysics Data System (ADS)

    Zimmerberg, Joshua

    2007-03-01

    In biology, curvature of intracellular membranes plays a key role in defining compartments to organize the interior of a cell and in creating the optimal shapes of organelles for function. We have studied how membrane curvature plays a crucial role in determining the energetics of membrane fusion in a number of systems. How the proteins that catalyze membrane fusion in cellular secretion and in viral fusion will be discussed in detail. Newer work on the role of proteins in the budding of viruses during assembly will be presented. The assembly of viruses also requires a concentration of viral protein components in the membrane. Recent experiments on cells expressing the influenza hemagglutinin show a clustering of proteins at many length scales. The dependence on cell cholesterol of this clustering (microdomain formation) will also be discussed.

  9. Fusion power for space propulsion.

    NASA Technical Reports Server (NTRS)

    Roth, R.; Rayle, W.; Reinmann, J.

    1972-01-01

    Principles of operation, interplanetary orbit-to-orbit mission capabilities, technical problems, and environmental safeguards are examined for thermonuclear fusion propulsion systems. Two systems examined include (1) a fusion-electric concept in which kinetic energy of charged particles from the plasma is converted into electric power (for accelerating the propellant in an electrostatic thrustor) by the van de Graaf generator principle and (2) the direct fusion rocket in which energetic plasma lost from the reactor has a suitable amount of added propellant to obtain the optimum exhaust velocity. The deuterium-tritium and the deuterium/helium-3 reactions are considered as suitable candidates, and attention is given to problems of cryogenic refrigeration systems, magnet shielding, and high-energy particle extraction and guidance.

  10. Membrane fusion and inverted phases

    SciTech Connect

    Ellens, H.; Siegel, D.P.; Alford, D.; Yeagle, P.L.; Boni, L.; Lis, L.J.; Quinn, P.J.; Bentz, J. (Univ. of California, San Francisco (USA))

    1989-05-02

    We have found a correlation between liposome fusion kinetics and lipid phase behavior for several inverted phase forming lipids. N-Methylated dioleoylphosphatidylethanolamine (DOPE-Me), or mixtures of dioleoylphosphatidylethanolamine (DOPE) and dioleoylphosphatidylcholine (DOPC), will form an inverted hexagonal phase (HII) at high temperatures (above TH), a lamellar phase (L alpha) at low temperatures, and an isotropic/inverted cubic phase at intermediate temperatures, which is defined by the appearance of narrow isotropic {sup 31}P NMR resonances. The phase behavior has been verified by using high-sensitivity DSC, {sup 31}P NMR, freeze-fracture electron microscopy, and X-ray diffraction. The temperature range over which the narrow isotropic resonances occur is defined as delta TI, and the range ends at TH. Extruded liposomes (approximately 0.2 microns in diameter) composed of these lipids show fusion and leakage kinetics which are strongly correlated with the temperatures of these phase transitions. At temperatures below delta TI, where the lipid phase is L alpha, there is little or no fusion, i.e., mixing of aqueous contents, or leakage. However, as the temperature reaches delta TI, there is a rapid increase in both fusion and leakage rates. At temperatures above TH, the liposomes show aggregation-dependent lysis, as the rapid formation of HII phase precursors disrupts the membranes. We show that the correspondence between the fusion and leakage kinetics and the observed phase behavior is easily rationalized in terms of a recent kinetic theory of L alpha/inverted phase transitions. In particular, it is likely that membrane fusion and the L alpha/inverted cubic phase transition proceed via a common set of intermembrane intermediates.

  11. Fusion algebras of logarithmic minimal models

    Microsoft Academic Search

    Jørgen Rasmussen; Paul A. Pearce

    2007-01-01

    We present explicit conjectures for the chiral fusion algebras of the logarithmic minimal models {\\\\cal LM}(p,p^{\\\\prime}) considering Virasoro representations with no enlarged or extended symmetry algebra. The generators of fusion are countably infinite in number but the ensuing fusion rules are quasi-rational in the sense that the fusion of a finite number of representations decomposes into a finite direct sum

  12. Revisions to the JDL data fusion model

    Microsoft Academic Search

    A. N. Steinberg; C. L. Bowman; F. E. White

    1999-01-01

    The Joint Directors of Laboratories {(JDL)} Data Fusion Group's Data Fusion Model is the most widely used method for categorizing data fusion-related functions. This model is modified to facilitate the cost-effective development, acquisition, integration and operation of multi-sensor\\/multi-source systems. Proposed modifications include broadening of the functional model and related taxonomy beyond the original military focus, and integrating the Data Fusion

  13. A Review of Data Fusion Techniques

    PubMed Central

    2013-01-01

    The integration of data and knowledge from several sources is known as data fusion. This paper summarizes the state of the data fusion field and describes the most relevant studies. We first enumerate and explain different classification schemes for data fusion. Then, the most common algorithms are reviewed. These methods and algorithms are presented using three different categories: (i) data association, (ii) state estimation, and (iii) decision fusion. PMID:24288502

  14. Revisions to the JDL data fusion model

    Microsoft Academic Search

    Alan N. Steinberg; Christopher L. Bowman; Franklin E. White

    1999-01-01

    The Data Fusion Model maintained by the Joint Directors of Laboratories (JDL) Data Fusion Group is the most widely-used method for categorizing data fusion-related functions. This paper discusses the current effort to revise the expand this model to facilitate the cost-effective development, acquisition, integration and operation of multi- sensor\\/multi-source systems. Data fusion involves combining information - in the broadest sense

  15. Z-Pinch Fusion for Energy Applications

    SciTech Connect

    SPIELMAN,RICK B.

    2000-01-01

    Z pinches, the oldest fusion concept, have recently been revisited in light of significant advances in the fields of plasma physics and pulsed power engineering. The possibility exists for z-pinch fusion to play a role in commercial energy applications. We report on work to develop z-pinch fusion concepts, the result of an extensive literature search, and the output for a congressionally-mandated workshop on fusion energy held in Snowmass, Co July 11-23,1999.

  16. Asymptotics of LQG fusion coefficients

    E-print Network

    Emanuele Alesci; Eugenio Bianchi; Elena Magliaro; Claudio Perini

    2008-10-05

    The fusion coefficients from SO(3) to SO(4) play a key role in the definition of spin foam models for the dynamics in Loop Quantum Gravity. In this paper we give a simple analytic formula of the EPRL fusion coefficients. We study the large spin asymptotics and show that they map SO(3) semiclassical intertwiners into $SU(2)_L\\times SU(2)_R$ semiclassical intertwiners. This non-trivial property opens the possibility for an analysis of the semiclassical behavior of the model.

  17. Environmental impact of fusion power

    SciTech Connect

    Fraas, A.P.

    1973-01-01

    From 140th meeting on the American Association for the Advancement of Science; San Francisco, California, USA (24 Feb The environmental effects of fusion power is considered assuming as a typical model a conceptual design for a full-scale fusion power plant. The appraisal indlcates that such a system would yield plentiful, cheap power for all of the world's energy requirements and provide fine solutions to most of the environmental pollution problems if the uncertainties in the plasma physics can be resolved in the fashion that current experiments lead one to expect. (auth)

  18. Fusion Breeder Program interim report

    SciTech Connect

    Moir, R.; Lee, J.D.; Neef, W.

    1982-06-11

    This interim report for the FY82 Fusion Breeder Program covers work performed during the scoping phase of the study, December, 1981-February 1982. The goals for the FY82 study are the identification and development of a reference blanket concept using the fission suppression concept and the definition of a development plan to further the fusion breeder application. The context of the study is the tandem mirror reactor, but emphasis is placed upon blanket engineering. A tokamak driver and blanket concept will be selected and studied in more detail during FY83.

  19. Z-Pinch Fusion Propulsion

    NASA Technical Reports Server (NTRS)

    Miernik, Janie

    2011-01-01

    Fusion-based nuclear propulsion has the potential to enable fast interplanetary transportation. Shorter trips are better for humans in the harmful radiation environment of deep space. Nuclear propulsion and power plants can enable high Ispand payload mass fractions because they require less fuel mass. Fusion energy research has characterized the Z-Pinch dense plasma focus method. (1) Lightning is form of pinched plasma electrical discharge phenomena. (2) Wire array Z-Pinch experiments are commonly studied and nuclear power plant configurations have been proposed. (3) Used in the field of Nuclear Weapons Effects (NWE) testing in the defense industry, nuclear weapon x-rays are simulated through Z-Pinch phenomena.

  20. Declarative Data Fusion Syntax, Semantics, and Implementation

    E-print Network

    Weske, Mathias

    level already have been solved, but conflicts on the data level remain. Data Fusion is then the processDeclarative Data Fusion ­ Syntax, Semantics, and Implementation Jens Bleiholder and Felix Naumann|naumann}@informatik.hu-berlin.de Abstract. In today's integrating information systems data fusion, i.e., the merging of multiple tuples

  1. Sensor selectivity and intelligent data fusion

    Microsoft Academic Search

    Stelios C. A. Thomopoulos

    1994-01-01

    The paper addresses the question of performance improvement as a result of multisensor data fusion and its ramifications on the design of a data fusion system. Sensor selectivity requires that data quality control and error detection capabilities be incorporated in the fusion design. Data quality control and error detection may not be feasible at the signal level requiring additional intelligence

  2. LIFE Power Plant Fusion Power Associates

    E-print Network

    LIFE Power Plant Fusion Power Associates December 14, 2011 Mike Dunne LLNL #12;NIf-1111-23714.ppt LIFE power plant 2 #12;LIFE delivery timescale NIf-1111-23714.ppt 3 #12;Timely delivery is enabled fusion options exist. NIF/LIFE allows timely integrated demonstration. · Fusion performance based

  3. FUSION CATEGORIES AND MODULE CATEGORIES EVAN JENKINS

    E-print Network

    Proudfoot, Nicholas

    FUSION CATEGORIES AND MODULE CATEGORIES EVAN JENKINS k is an algebraically closed field of bilinear functors C × D E. 2. Fusion categories Definition. Let C be a tensor/monoidal category. C is called a fusion category if (1) Every object has a left and right dual (2) 1 is simple. Examples (G

  4. Exotic fusion systems over 2-groups

    E-print Network

    Thévenaz, Jacques

    Exotic fusion systems over 2-groups Bob Oliver joint with Kasper Andersen and Joana Ventura The fusion category of a finite group G encodes the conjugacy relations within a Sylow p-subgroup S of GFS(G)(P, Q) = HomG(P, Q). 1 #12;The notion of an abstract fusion system is due to Puig. The definitions we

  5. Scapholunate fusion in chronic symptomatic scapholunate instability

    Microsoft Academic Search

    A. I. Zubairy; W. A. Jones

    2003-01-01

    Since 1989 scapholunate fusion has been performed on 13 patients with chronic scapholunate instability causing debilitating symptoms. These cases were reviewed at a mean 93 (range, 60–132) months after surgery. Establishing whether bony fusion had been achieved proved extremely difficult even after CT scanning, but fusion was unequivocally achieved in four cases. Ten patients were subjectively satisfied with their treatment.

  6. Decision fusion strategies in multisensor environments

    Microsoft Academic Search

    Belur V. Dasarathy

    1991-01-01

    Efficient decision fusion strategies for deriving optimal decisions in multisensor target recognition\\/tracking environments are analyzed. The problem is viewed as one of parallel fusion of the individual independent decisions with a recursive structure that permits enhancement of the reliability of the fused decision. Instead of a voting-based fusion approach, this recursive structure can be combined with any one of the

  7. Materials needs for compact fusion reactors

    Microsoft Academic Search

    R. A. Krakowski

    1983-01-01

    The economic prospects for magnetic fusion energy is dramatically improved if for the same total power output the fusion neutron first-wall (FW) loading and the system power density is increased by factors of 3 to 5 and 10 to 30, respectively. A number of compact fusion reactor embodiments were proposed, all of which would operate with increased FW loadings, would

  8. Compact Fusion Advanced Rankine (CFARII) power cycle

    Microsoft Academic Search

    Logan

    1991-01-01

    The Compact Fusion Advanced Rankine (CFARII) power cycle is a direct plasma energy conversion scheme for inertial fusion (ICF) and magnetically-insulated, inertially confined fusion (MICF) reactors utilizing: (1) conversion of plasma thermal ionization and thermal energy into kinetic energy of a supersonic plasma jet, (2) conversion of the plasma jet kinetic energy into DC electricity by slowing down in an

  9. MAST-Upgrade Advancing compact fusion sources

    E-print Network

    MAST-Upgrade Advancing compact fusion sources #12;#12;The Mega Amp Spherical Tokamak (MAST) is the centrepiece of the UK's fusion research programme. It has led studies into the spherical tokamak, a compact to the drive towards commercial fusion power. 1. Testing reactor concepts. MAST-Upgrade will be the first

  10. Fusion Lecture Summary Eugene S. Evans

    E-print Network

    Budker, Dmitry

    Fusion Lecture Summary Eugene S. Evans Physics H190, University of California, Berkeley March 31" by Edward I. Moses (Principle Associate Director, National Ignition Facility and Photon Science) Eugene S Fusion Engine (LIFE) Final Thoughts 5 Acknowledgements Eugene S. Evans (2010) Fusion Lecture Summary

  11. Survey on game-theoretic information fusion

    Microsoft Academic Search

    Huilin Yin; Lei Wang; Jing Nong

    2010-01-01

    This paper surveys the research of the information fusion approaches based on game theory. How to resolve the high level fusion problem in the conflict and cooperation environment of multiple sources information is a key problem in the current research of information fusion. Game theory is promising to successfully model conflict and cooperative interactions. So, the relatively new interdisciplinary study

  12. Some terms of reference in data fusion

    Microsoft Academic Search

    Lucien Wald

    1999-01-01

    This paper discusses the needs for a concept and harmonized terms of reference in data fusion. Previously published definitions are analyzed. A new definition of the data fusion is proposed which has been set within an European working group. Several definitions and terms of reference are given which describe the information intervening in any problem of data fusion

  13. DFuse: a framework for distributed data fusion

    Microsoft Academic Search

    Rajnish Kumar; Matthew Wolenetz; Bikash Agarwalla; JunSuk Shin; Phillip W. Hutto; Arnab Paul; Umakishore Ramachandran

    2003-01-01

    Simple in-network data aggregation (or fusion) techniques for sensor networks have been the focus of several recent research efforts, but they are insufficient to support advanced fusion applications. We extend these techniques to future sensor networks and ask two related questions: (a) what is the appropriate set of data fusion techniques, and (b) how do we dynamically assign aggregation roles

  14. Image fusion experiment for information content

    Microsoft Academic Search

    Karthik P. Ramesh; Shruti Gupta; Erik P. Blasch

    2007-01-01

    Recent developments in image fusion have produced a variety of approaches like image overlay, image sharpening, and image cueing through pixel, feature, or region\\/shape combinations. The applicability of these approaches and techniques differ on the image content, contextual information, and generalized metrics of image fusion gain. An image fusion gain can be assessed relative to information gain or entropy reduction.

  15. A tutorial on multisensor integration and fusion

    Microsoft Academic Search

    REN C. LUO; MICHAEL G. KAY

    1990-01-01

    A tutorial introduction to the subject of multisensor integration and fusion is presented. The role of multisensor integration and fusion in the operation of intelligent systems is defined in terms of the unique type of information multiple sensors can provide. Multisensor integration is discussed in terms of basic integration functions and multisensor fusion in terms of the different levels at

  16. Robust data fusion for multisensor detection systems

    Microsoft Academic Search

    Evaggelos Geraniotis; Yawgeng A. Chau

    1990-01-01

    Minimax robust data fusion schemes for multisensor detection systems with discrete-time observations characterized by statistical uncertainty are developed and analyzed. Block, sequential, and serial fusion rules are considered. The performance measures used, and made robust with respect to the uncertainties, include the error probabilities of the hypothesis testing problem in the block fusion case and the error probabilities and expected

  17. Multisensor data fusion using neural networks

    Microsoft Academic Search

    D. Wade Fincher; Dwight F. Mix

    1990-01-01

    A general approach to the use of neural networks for data fusion is outlined. The discussion begins with examples of data fusion problems and a pattern recognition example is given to illustrate the concepts involved in data fusion. The differences between using post- and pre-detection signals and the advantages of using the latter are discussed. How to apply a neural

  18. Simulation Based Multisensor Data Fusion Tool

    Microsoft Academic Search

    Faruk SARI; N. Sari

    2006-01-01

    In this paper, a generic and expandable rule-based fusion tool on a command control system is presented. The main objective of our fusion tool is to execute a generic, user-friendly information fusion process via a database using rules, which can be defined during run time

  19. Minimum entropy approach for multisensor data fusion

    Microsoft Academic Search

    Yifeng Zhou; Henry Leung

    1997-01-01

    In this paper, we present a minimum entropy fusion approach for multisensor data fusion in non-Gaussian environments. We represent the fused data in the form of the weighted sum of the multisensor outputs and use the varimax norm as the information measure. The optimum weights are obtained by maximizing the varimax norm of the fused data. The minimum entropy fusion

  20. Fuzzy methods for multisensor data fusion

    Microsoft Academic Search

    Fabrizio Russo; Giovanni Ramponi

    1994-01-01

    This paper presents a new general framework for information fusion based on fuzzy methods. In the proposed architecture, feature extraction and feature fusion are performed by adopting a class of (possibly multidimensional) membership functions which take care of the possibility and admissibility of the feature itself. Test cases of one-dimensional and image data fusion are presented

  1. Random Weighting Method for Multisensor Data Fusion

    Microsoft Academic Search

    Shesheng Gao; Yongmin Zhong; Wei Li

    2011-01-01

    This paper presents a new data fusion method by adopting random weighting estimation for optimal weighted fusion of multisensor observation data. This method adjusts in real time the weights of individual sensors according to variations in estimated sensor variances to obtain optimal weight distribu- tion. Theories of random weighting estimation are established for optimal data fusion through optimal weighting distribution.

  2. Figure of merit of magnetic fusion reactor

    Microsoft Academic Search

    Kazawa

    1986-01-01

    This paper proposes and defines ''the figure of merit of fusion reactor'' F which can indicate the economics of fusion reactor comparatively simply and easily by using every important evaluation factor. An attempt to express it synthetically in a numerical formula as to magnetic confined fusion reactor is made. By means of this evaluation formula F, some evaluation studies are

  3. Safety and environmental aspects of fusion reactors

    Microsoft Academic Search

    Holdren

    1976-01-01

    Fusion is examined against the yardstick of fission technology with respect to inventories of radioactivity (and associated Biological Hazard Potentials), routine emissions, accident pathways and consequences, radioactive-waste management, and misuse of nuclear materials. Based on conceptual designs of Tokamak fusion reactors with stainless steel structure and tritium inventories of 10 kg per thermal gigawatt, the apparent advantage of fusion is

  4. Safety review of conceptual fusion power plants

    Microsoft Academic Search

    1976-01-01

    The potential public safety impacts from accidents in conceptual fusion power plants were investigated. Fusion was found to have some potential for accidents, as does any energy generating system. Functions of fusion power plants were identified that possess sufficient potential for an accidental release of toxic materials to the environment. An assessment was made of the impact of the potential

  5. Status and problems of fusion reactor development

    Microsoft Academic Search

    Uwe Schumacher

    2001-01-01

    Thermonuclear fusion of deuterium and tritium constitutes an enormous potential for a safe, environmentally compatible and sustainable energy supply. The fuel source is practically inexhaustible. Further, the safety prospects of a fusion reactor are quite favourable due to the inherently self-limiting fusion process, the limited radiologic toxicity and the passive cooling property. Among a small number of approaches, the concept

  6. Breathing Signal Fusion in Pressure Sensor Arrays

    Microsoft Academic Search

    M. Holtzman; A. Arcelus; R. Goubran; F. Knoefel

    2008-01-01

    Pressure sensors can be used to unobtrusively obtain breathing signals from a person in bed. Obtaining a single representation of the breathing signal from an array of such sensors requires data-level fusion. We propose a decision directed adaptive linear estimator to perform this fusion online. The proposed method was compared with three other online fusion methods and two offline methods

  7. Antimatter Driven PB11 Fusion Propulsion System

    Microsoft Academic Search

    Terry Kammash; James Martin; Thomas Godfroy

    2003-01-01

    One of the major advantages of using P-B11 fusion fuel is that the reaction produces only charged particles in the form of three alpha particles and no neutrons. A fusion concept that lends itself to this fuel cycle is the Magnetically Insulated Inertial Confinement Fusion (MICF) reactor whose distinct advantage lies in the very strong magnetic field that is created

  8. Laser Fusion Research at NRL Fusion Power Associates Meeting

    E-print Network

    are conducted on the Nike KrF facility Nike is operated by 3 technicians Nike's angularly multiplexed optical experiments with Nike facility Success with inertial fusion requires a precise understanding of the underlying physics. The NRL program helps develop the basic physics of ICF using its Nike laser facility, theory

  9. Decontamination of Lead by Fusion; DECONTAMINATION DU PLOMB PAR FUSION

    Microsoft Academic Search

    P. Boutot; L. Giachetto; A. Capitaine

    1962-01-01

    A fusion decontamination method was developed. The apparatus consists ; of a propane-heated oven fitted with a steel crucible of 1400 kg capacity, with ; two ventilation systems, and with a depressometer for preventing the diffusion of ; toxic gases. There are operational controls on the samples taken before, during, ; and after the operation, on the plugs taken from

  10. Scientific Breakeven for Fusion Energy For the past 40 years, the IFE fusion research community has adopted: achieving a fusion gain of 1 as

    E-print Network

    , with fusion energy equal to laser energy. The LLNL definition of scientific breakeven was also published inScientific Breakeven for Fusion Energy For the past 40 years, the IFE fusion research community has as fusion energy produced divided the external energy incident on the fusion reaction chamber. Typical

  11. The status of `cold fusion'

    Microsoft Academic Search

    David J. Nagel

    1998-01-01

    The questions raised by reports of nuclear reactions at low energies, so called `cold fusion', are not yet answered to the satisfaction of many scientists. Further experimental investigations of these and related questions seems desirable, at least for scientific if not practical reasons. Properly conducted, such investigations would be indistinguishable from normal research. They would yield information germane to accepted

  12. Fusion plasma diagnostics with microwaves

    Microsoft Academic Search

    Hans J Hartfuss

    2010-01-01

    An introductory overview is given on the established methods of probing magnetically confined hot fusion plasmas with microwaves in the mm and sub-mm wavelength regions. Since the plasma dielectric properties are mainly determined by the electron component of the plasma, primarily information on this component is being achieved. The methods can be divided into active and passive diagnostics. Applying the

  13. High-gain aneutronic fusion

    NASA Astrophysics Data System (ADS)

    Hay, M. J.; Fisch, N. J.

    2014-10-01

    Fusion reactions which release most of their energy in charged particles are desirable for power applications. The proton-boron reaction p+11 B --> 3 ? + 8 . 7 MeV is ideal due to the low incidence of neutron-generating side reactions and the natural abundance of the reactants. However, an optically thin proton-boron plasma radiates a substantial amount of energy via bremsstrahlung. To compensate, we consider ways of increasing the fusion reactivity above the Maxwellian value. Using the fusion alpha particle energy to heat specific parts of the proton velocity distribution is one such approach. In principle, waves could channel the alpha energy to protons near the cross section maximum in energy, resulting in a substantial reactivity gain. By making aggressive assumptions regarding how energy might be channeled, we present upper bounds on the extent to which a proton-boron fusion reaction can be self-sustaining. Work supported by DOE Contract No. DE-AC02-09CH11466 and DOE NNSA SSAA Grant No. DE274-FG52-08NA28553. M. J. H. was supported in part by the DOE NNSA SSGF under Grant No. DE-FC52-08NA28752.

  14. HEDL magnetic fusion energy programs

    Microsoft Academic Search

    D. G. Doran

    1978-01-01

    Progress is described in three HEDL programs supported by the U.S. Department of Energy's Division of Magnetic Fusion Energy. They are: (1) irradiation effects analysis, (2) mechanical performance of MFE materials, and (3) preparation and presentation of design data. Helium production cross sections for isotopes of Fe, Ni, and Cr, calculated with the HAUSER 4 code, are tabulated at 15

  15. Fusion Energy Research Presentation to

    E-print Network

    Decision point DEMO Volumetric neutron source Theory & Simulation ICC ETR DEMO #12;Advanced Computing is Critical to Discovery in Many Scientific Disciplines Subsurface Transport Global Systems DOE Science and fusion science. Our primary mission is to develop the scientific understanding and the key innovations

  16. CELL BIOLOGY: Fusion Without SNAREs?

    NSDL National Science Digital Library

    Suzie J. Scales (Genentech Inc.; )

    2001-11-02

    Access to the article is free, however registration and sign-in are required. Highly orchestrated molecular rearrangements are required for two membranes to fuse, as happens, for example, during neurotransmitter release into the synapse. In an elegant Perspective, Scales et al. discuss two studies (Schoch et al., Wang et al.) that shed new light on the protein interactions involved in membrane fusion.

  17. Laser Inertial Fusion-based

    E-print Network

    -ray energy over a timescale thermal conduction can effectively remove it #12;Chamber conditions must support = 61% Gfusion = 51 42 MW laser 1807 MW fusion Gblanket = 1.2 2168 MW thermal 303 MWe (27% recirc) 25 injector parameters satisfy fratricide constraints: ­ Injector nozzle ~15 m from chamber center ­ Two mean

  18. On the Theory of Fusion

    Microsoft Academic Search

    K. F. Herzfeld; Maria Goeppert Mayer

    1934-01-01

    Although equilibrium between two phases is in general determined by both phases, fusion stands somewhat apart in that a crystal cannot be overheated. As a type of the simplest possible crystal, the exact equation of state of frozen argon has been developed here. It has been found that the pressure as function of the volume at a given temperature has

  19. Multisource fusion for target detection

    NASA Astrophysics Data System (ADS)

    Izraelevitz, David; Cochand, Jeffrey A.

    1990-11-01

    An approach to the fusion of information from airborne sensors for the purpose of target detection is described. This approach differs from alternate strategies in that the fusion occurs at the target hypothesis level, a symbolic level, rather than at the sensor level, i.e., candidate target coordinates are merged into correlated target hypotheses. Thus, a source in this approach consists of both a sensor which provides data about the target environment, and a list of candidate target coordinates generated as output from a target detection algorithm. The fusion algorithm is based on generating a statistical model for the detection and false alarm performance of each target coordinate source. Special emphasis is placed on modeling the positional misregistration which occurs when imagery is extracted from different platforms. An iterative clustering algorithm is derived from the source models based on a maximum likelihood target location estimation approach. Results of multisource fusion on several synthetic datasets are provided which indicate the encouraging performance of the system even under severe clutter and sensor misregistration conditions.

  20. Epoxy fusion catalyst and process

    Microsoft Academic Search

    1989-01-01

    A process is described for preparing an advanced epoxy resin from a reaction mixture containing at least about 0.01 weight percent water, the process comprising: contacting in the reaction mixture a polyepoxide having an average of more than 1 vicinal epoxide group per molecule and a weight per epoxide less than about 500 with a fusion compound selected from the

  1. Interface Model of Cold Fusion

    Microsoft Academic Search

    Talbot A. Chubb

    The interface theory of cold fusion is a variant of Ion Band State (IBS) Theory.1 It models Bloch symmetry deuterons in a 2-dimensional metal lattice instead of the 3-dimensional metal lattice first used. Both IBS variants recognize that the required lattice symmetry has limited extent, with the reactive deuterons being bound inside a closed volume like a box. The reactive

  2. Proton Collimators for Fusion Reactors

    NASA Technical Reports Server (NTRS)

    Miley, George H.; Momota, Hiromu

    2003-01-01

    Proton collimators have been proposed for incorporation into inertial-electrostatic-confinement (IEC) fusion reactors. Such reactors have been envisioned as thrusters and sources of electric power for spacecraft and as sources of energetic protons in commercial ion-beam applications.

  3. Prospects for spheromak fusion reactors

    Microsoft Academic Search

    T. K. Fowler; D. D. Hua

    1995-01-01

    The reactor study of Hagenson and Krakowski demonstrated the attractiveness of the spheromak as a compact fusion reactor, based on physics principles confirmed in CTX experiments in many respects. Most uncertain was the energy confinement time and the role of magnetic turbulence inherent in the concept. In this paper, a one-dimensional model of heat confinement, calibrated by CTX, predicts negligible

  4. Cognitive high level information fusion

    Microsoft Academic Search

    Leonid I. Perlovsky

    2007-01-01

    Fusion of sensor and communication data currently can only be performed at a late processing stage after sensor and textual information are formulated as logical statements at appropriately high level of abstraction. Contrary to this it seems, the human mind integrates sensor and language signals seamlessly, before signals are understood, at pre-conceptual level. Learning of conceptual contents of the surrounding

  5. University Fusion Association General Meeting

    E-print Network

    University Fusion Association General Meeting Monday, 30 October 2006 6:00 PM ­ 7:30 PM Grand for 2006 Term Ending Jan 1, 2009 David Meyerhoffer, University of Rochester Uri Shumlak, University of Washington Matt Stoneking, Lawrence University George Tynan, UCSD Term Ending Jan 1, 2008 Boris Briezman

  6. Fusion Test Facilities John Sheffield

    E-print Network

    Fusion Test Facilities John Sheffield ISSE - University of Tennessee FPA meeting Livermore December Stambaugh, and their colleagues #12;Destructive Testing · It is common practice to test engineered components to destruction prior to deployment of a system e.g., - Automobile crash tests - Airplane wing

  7. RMF Driven FRC Fusion Reactor

    NASA Astrophysics Data System (ADS)

    Slough, John

    2001-10-01

    There have been several experiments in the past that have formed and sustained a field reversed configuration (FRC) with a rotating magnetic field (RMF). But it is only recently that the confinement and scaling properties of these plasmas have been assessed. While this work is still ongoing, recent experiments where there has been adequate separation of the FRC from wall contact, the confinement and stability of the plasmas look promising. These RMF driven FRCs display a resistivity comparable to that predicted by past FRC experiments. Enhanced particle confinement with much better confinement than previous FRC scaling has also been observed. Even with a scaling no better than that observed in past FRC experiments, a fusion system based solely on RMF driven currents is envisioned to be feasible. The fusion system would be compact (rp < 0.1 m), and would operate with a significant RMF field ( 1 T). The power flow into the FRC during formation would reach several hundred MW and ohmically heat the FRC to fusion conditions in less than 1 ms. Although the RMF field is large, the necessary oscillating currents are well within the capability of current solid-state switching technology. Details of the final reactor size and power depend on the confinement scaling observed as RMF plasmas reach more fusion relevant conditions. Various scenarios based on different scalings will also presented

  8. Tritium breeding in fusion reactors

    SciTech Connect

    Abdou, M.A.

    1982-10-01

    Key technological problems that influence tritium breeding in fusion blankets are reviewed. The breeding potential of candidate materials is evaluated and compared to the tritium breeding requirements. The sensitivity of tritium breeding to design and nuclear data parameters is reviewed. A framework for an integrated approach to improve tritium breeding prediction is discussed with emphasis on nuclear data requirements.

  9. Sensor Fusion for Video Surveillance

    Microsoft Academic Search

    Lauro Snidaro; Gian Luca Foresti; Ruixin Niu; Pramod K. Varshney

    2004-01-01

    In this paper, a multisensor data fusion system for object tracking is presented. It is able to track in real-time multiple targets in outdoor environments. The system can take advantage of the redundant information coming from different sensors monitoring the same scene. The measurements (positions of the targets) obtained from the available sources are fused together to obtain a more

  10. Data Fusion with Record Linkage

    Microsoft Academic Search

    Mattis Neiling

    1998-01-01

    Assuming that there are two sources (e.g. files), which consist ofrecords with different informations about some units like people. Wewant to fusion the information (data) that belong to the same units.Very often in practice no identification numbers --- like the SocialSecurity Number SSN --- are available at both files, that's why thereis some uncertainity, which records belong together. Anyway, we

  11. Is NSF a fusion protein?

    Microsoft Academic Search

    Alan Morgan; Robert D. Burgoyne

    1995-01-01

    N-ethylmaleimide-sensitive fusion protein (NSF) is an ATPase required for vesicular transport throughout the constitutive secretory and endocytic pathways. Recently, NSF has also been implicated in regulated exocytosis in synapses - based on SNAP-mediated binding in vitro to a complex of neurotoxin substrates (termed ‘SNAREs’). This work has generated an hypothesis in which the interaction of SNARES (SNAP receptors) on the

  12. Liquid metal fusion reactor systems

    Microsoft Academic Search

    B. G. Karasev; A. V. Tananaev

    1990-01-01

    The main conceptual designs of liquid metal blanket, methods of pressure drop decrease in the strong magnetic field of the fusion reactor are being discussed. Special features of the flows of electrically conductive fluids in the strong magnetic fields (N? M? 1) are examined. The approximate limits of the transition to the linear (Stokes) flow in the characteristic elements of

  13. Fusion Nuclear Science Facility (FNSF)

    E-print Network

    -material interactions, tritium fuel cycle, and power extraction. · Wide time and size scales of synergistic phenomenaFusion Nuclear Science Facility (FNSF) ­ Motivation, Role, Required Capabilities YK Martin Peng involving plasma facing material and tritium retention · W, a promising Plasma Facing Material - Low H

  14. Distribution Category: Magnetic Fusion Energy

    E-print Network

    Abdou, Mohamed

    LABORATORY 9700 South Cass Avenue Argonne, Illinois 60439 TRITIUM BREEDING IN FUSION REACTORS by Mohaned A in the Inboard Blanket 18 4.3 Fast and Thermal Systems 19 4.4 Neutron Multipliers 24 4.5 Conclusions on Breeding References 49 iii #12;LIST OF FIGURES FIGURE NO. TITLE PAGE 1 17Li-83Pb liquid alloy breeder first wall

  15. An introduction to multisensor data fusion

    SciTech Connect

    Hall, D.L. [Pennsylvania State Univ., University Park, PA (United States). Applied Research Lab.] [Pennsylvania State Univ., University Park, PA (United States). Applied Research Lab.; Llinas, J. [State Univ. of New York, Buffalo, NY (United States)] [State Univ. of New York, Buffalo, NY (United States)

    1997-01-01

    Multisensor data fusion is an emerging technology applied to Department of Defense (DoD) areas such as automated target recognition, battlefield surveillance, and guidance and control of autonomous vehicles, and to non-DoD applications such as monitoring of complex machinery, medical diagnosis, and smart buildings. Techniques for multisensor data fusion are drawn from a wide range of areas including artificial intelligence, pattern recognition, statistical estimation, and other areas. This paper provides a tutorial on data fusion, introducing data fusion applications, process models, and identification of applicable techniques. Comments are made on the state-of-the-art in data fusion.

  16. Fusion probability in heavy nuclei

    NASA Astrophysics Data System (ADS)

    Banerjee, Tathagata; Nath, S.; Pal, Santanu

    2015-03-01

    Background: Fusion between two massive nuclei is a very complex process and is characterized by three stages: (a) capture inside the potential barrier, (b) formation of an equilibrated compound nucleus (CN), and (c) statistical decay of the CN leading to a cold evaporation residue (ER) or fission. The second stage is the least understood of the three and is the most crucial in predicting yield of superheavy elements (SHE) formed in complete fusion reactions. Purpose: A systematic study of average fusion probability, , is undertaken to obtain a better understanding of its dependence on various reaction parameters. The study may also help to clearly demarcate onset of non-CN fission (NCNF), which causes fusion probability, PCN, to deviate from unity. Method: ER excitation functions for 52 reactions leading to CN in the mass region 170-220, which are available in the literature, have been compared with statistical model (SM) calculations. Capture cross sections have been obtained from a coupled-channels code. In the SM, shell corrections in both the level density and the fission barrier have been included. for these reactions has been extracted by comparing experimental and theoretical ER excitation functions in the energy range ˜5 %-35% above the potential barrier, where known effects of nuclear structure are insignificant. Results: has been shown to vary with entrance channel mass asymmetry, ? (or charge product, ZpZt ), as well as with fissility of the CN, ?CN. No parameter has been found to be adequate as a single scaling variable to determine . Approximate boundaries have been obtained from where starts deviating from unity. Conclusions: This study quite clearly reveals the limits of applicability of the SM in interpreting experimental observables from fusion reactions involving two massive nuclei. Deviation of from unity marks the beginning of the domain of dynamical models of fusion. Availability of precise ER cross sections over a wider energy range for many more reactions is desired for accurate determination of and more insight into the dynamics of fusion in the heavy mass region.

  17. Data security on the national fusion grid

    SciTech Connect

    Burruss, Justine R.; Fredian, Tom W.; Thompson, Mary R.

    2005-06-01

    The National Fusion Collaboratory project is developing and deploying new distributed computing and remote collaboration technologies with the goal of advancing magnetic fusion energy research. This work has led to the development of the US Fusion Grid (FusionGrid), a computational grid composed of collaborative, compute, and data resources from the three large US fusion research facilities and with users both in the US and in Europe. Critical to the development of FusionGrid was the creation and deployment of technologies to ensure security in a heterogeneous environment. These solutions to the problems of authentication, authorization, data transfer, and secure data storage, as well as the lessons learned during the development of these solutions, may be applied outside of FusionGrid and scale to future computing infrastructures such as those for next-generation devices like ITER.

  18. Security on the US Fusion Grid

    SciTech Connect

    Burruss, Justin R.; Fredian, Tom W.; Thompson, Mary R.

    2005-06-01

    The National Fusion Collaboratory project is developing and deploying new distributed computing and remote collaboration technologies with the goal of advancing magnetic fusion energy research. This work has led to the development of the US Fusion Grid (FusionGrid), a computational grid composed of collaborative, compute, and data resources from the three large US fusion research facilities and with users both in the US and in Europe. Critical to the development of FusionGrid was the creation and deployment of technologies to ensure security in a heterogeneous environment. These solutions to the problems of authentication, authorization, data transfer, and secure data storage, as well as the lessons learned during the development of these solutions, may be applied outside of FusionGrid and scale to future computing infrastructures such as those for next-generation devices like ITER.

  19. 2002 Fusion Summer Study Executive Summary

    NASA Astrophysics Data System (ADS)

    Bangerter, Roger; Navratil, Gerald; Sauthoff, Ned

    2001-09-01

    The 2002 Fusion Summer Study was conducted July 8-19, 2002, in Snowmass, CO, and carried out a critical assessment of major next steps in the fusion energy sciences program in both magnetic fusion energy (MFE) and inertial fusion energy (IFE). The conclusions of this study were based on analysis led by over 60 conveners working with hundreds of members of the fusion energy sciences community extending over eight months. This effort culminated in two weeks of intense discussion by over 250 U.S. and 30 foreign fusion physicists and engineers present at the 2002 Fusion Summer Study. This is the Executive Summary of the study report. Details are posted at http://web.gat.com/snowmass

  20. Measuring time of flight of fusion products in an inertial electrostatic confinement fusion device for spatial profiling of fusion reactions

    SciTech Connect

    Donovan, D. C. [Sandia National Laboratories, 7011 East Avenue, Livermore, California 94550 (United States); Boris, D. R. [Naval Research Laboratory, 4555 Overlook Avenue, South West, Washington, DC 20375 (United States); Kulcinski, G. L.; Santarius, J. F. [Fusion Technology Institute, University of Wisconsin-Madison, 1500 Engineering Drive, Madison, Wisconsin 53706 (United States); Piefer, G. R. [Phoenix Nuclear Labs, 2555 Industrial Drive, Madison, Wisconsin 53713 (United States)

    2013-03-15

    A new diagnostic has been developed that uses the time of flight (TOF) of the products from a nuclear fusion reaction to determine the location where the fusion reaction occurred. The TOF diagnostic uses charged particle detectors on opposing sides of the inertial electrostatic confinement (IEC) device that are coupled to high resolution timing electronics to measure the spatial profile of fusion reactions occurring between the two charged particle detectors. This diagnostic was constructed and tested by the University of Wisconsin-Madison Inertial Electrostatic Confinement Fusion Group in the IEC device, HOMER, which accelerates deuterium ions to fusion relevant energies in a high voltage ({approx}100 kV), spherically symmetric, electrostatic potential well [J. F. Santarius, G. L. Kulcinski, R. P. Ashley, D. R. Boris, B. B. Cipiti, S. K. Murali, G. R. Piefer, R. F. Radel, T. E. Radel, and A. L. Wehmeyer, Fusion Sci. Technol. 47, 1238 (2005)]. The TOF diagnostic detects the products of D(d,p)T reactions and determines where along a chord through the device the fusion event occurred. The diagnostic is also capable of using charged particle spectroscopy to determine the Doppler shift imparted to the fusion products by the center of mass energy of the fusion reactants. The TOF diagnostic is thus able to collect spatial profiles of the fusion reaction density along a chord through the device, coupled with the center of mass energy of the reactions occurring at each location. This provides levels of diagnostic detail never before achieved on an IEC device.

  1. Fusion energy calorimeter for the tokamak fusion test reactor

    SciTech Connect

    Jassby, D.L.; Imel, G.R.

    1981-04-01

    One and two-dimensional neutronic analyses treating the transport and scattering of neutrons and the production and transport of gamma rays in the TFTR demonstrate that the fusion energy production in a D-T pulse in the TFTR can be determined with an uncertainty of +- 15% or less, simply by integrating the measured profile of temperature increase along the central radial axis of a large hydrocarbon moderator that fills the bay between adjacent toroidal-field coils, just outside the vacuum vessel. Limitations in thermopile temperature measurements dictate a minimum fusion-neutron fluence at the vacuum vessel of the order of 10/sup 12/ n/cm/sup 2/ per pulse (a source strength of 10/sup 18/ n/pulse in TFTR), in order that this simple calorimeter can provide useful accuracy.

  2. Observations of membrane fusion in a liposome dispersion: the missing fusion intermediate?

    PubMed Central

    Foldvari, Marianna

    2015-01-01

    Early intermediate structures of liposome-liposome fusion events were captured by freeze-fracture electron microscopic (EM) technique. The images show the morphology of the fusion interface at several different stages of the fusion event. One of the intermediates was captured at a serendipitous stage of two vesicles’ membranes (both leaflets) merging and their contents starting to intermix clearly showing the fusion interface with a previously unseen fusion rim. From the morphological information a hypothetical sequence of the fusion event and corresponding lipid structural arrangements are described.

  3. Fusion technologies for Laser Inertial Fusion Energy (LIFE)

    NASA Astrophysics Data System (ADS)

    Kramer, K. J.; Latkowski, J. F.; Abbott, R. P.; Anklam, T. P.; Dunne, A. M.; El-Dasher, B. S.; Flowers, D. L.; Fluss, M. J.; Lafuente, A.; Loosmore, G. A.; Morris, K. R.; Moses, E.; Reyes, S.

    2013-11-01

    The Laser Inertial Fusion-based Energy (LIFE) engine design builds upon on going progress at the National Ignition Facility (NIF) and offers a near-term pathway to commercial fusion. Fusion technologies that are critical to success are reflected in the design of the first wall, blanket and tritium separation subsystems. The present work describes the LIFE engine-related components and technologies. LIFE utilizes a thermally robust indirect-drive target and a chamber fill gas. Coolant selection and a large chamber solid-angle coverage provide ample tritium breeding margin and high blanket gain. Target material selection eliminates the need for aggressive chamber clearing, while enabling recycling. Demonstrated tritium separation and storage technologies limit the site tritium inventory to attractive levels. These key technologies, along with the maintenance and advanced materials qualification program have been integrated into the LIFE delivery plan. This describes the development of components and subsystems, through prototyping and integration into a First Of A Kind power plant. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  4. Multiscale Medical Image Fusion in Wavelet Domain

    PubMed Central

    Khare, Ashish

    2013-01-01

    Wavelet transforms have emerged as a powerful tool in image fusion. However, the study and analysis of medical image fusion is still a challenging area of research. Therefore, in this paper, we propose a multiscale fusion of multimodal medical images in wavelet domain. Fusion of medical images has been performed at multiple scales varying from minimum to maximum level using maximum selection rule which provides more flexibility and choice to select the relevant fused images. The experimental analysis of the proposed method has been performed with several sets of medical images. Fusion results have been evaluated subjectively and objectively with existing state-of-the-art fusion methods which include several pyramid- and wavelet-transform-based fusion methods and principal component analysis (PCA) fusion method. The comparative analysis of the fusion results has been performed with edge strength (Q), mutual information (MI), entropy (E), standard deviation (SD), blind structural similarity index metric (BSSIM), spatial frequency (SF), and average gradient (AG) metrics. The combined subjective and objective evaluations of the proposed fusion method at multiple scales showed the effectiveness and goodness of the proposed approach. PMID:24453868

  5. Mirror fusion vacuum technology developments

    SciTech Connect

    Batzer, T.H.; Call, W.R.

    1983-11-21

    Magnetic Mirror Fusion experiments, such as MFTF-B+T (Mirror Fusion Test Facility-B, Tritium Upgrade) and foreseeable follow-on devices, have operational and maintenance requirements that have not yet been fully demonstrated. Among those associated with vacuum technology are the very-high continuous-pumping speeds, 10/sup 7/ to 10/sup 8/ l/s for D/sub 2/, T/sub 2/ and, to a lesser extent, He; the early detection of water leaks from the very-high heat-flux neutral-beam dumps and the detection and location of leaks in the superconducting magnets not protected by guard vacuums. Possible solutions to these problems have been identified and considerable progress has been made toward successfully demonstrating their feasibility.

  6. Investigation of condensed matter fusion

    SciTech Connect

    Jones, S.E.; Berrondo, M.; Czirr, J.B.; Decker, D.L.; Harrison, K.; Jensen, G.L.; Palmer, E.P.; Rees, L.B.; Taylor, S.; Vanfleet, H.B.; Wang, J.C.; Bennion, D.N.; Harb, J.N.; Pitt, W.G.; Thorne, J.M.; Anderson, A.N.; McMurtry, G.; Murphy, N.; Goff, F.E.

    1990-12-01

    Work on muon-catalyzed fusion led to research on a possible new type of fusion occurring in hydrogen isotopes embedded in metal lattices. While the nuclear-product yields observed to date are so small as to require careful further checking, rates observed over short times appear sufficiently large to suggest that significant neutrons and triton yields could be realized -- if the process could be understood and controlled. During 1990, we have developed two charged-particle detection systems and three new neutron detectors. A segmented, high-efficiency neutron counter was taken into 600 m underground in a mine in Colorado for studies out of the cosmic-ray background. Significant neutron emissions were observed in this environment in both deuterium-gas-loaded metals and in electrolytic cells, confirming our earlier observations.

  7. Overview of advanced fuel fusion

    SciTech Connect

    Miley, G.H.

    1989-01-01

    The status and issues related to the development of advanced fuel fusion are discussed. D-{sup 3}He is a key advanced fuel since it has the potential of igniting in a variety of confinement concepts. However, to obtain a plentiful source of {sup 3}He, either lunar mining or breeding becomes necessary. Highly non-Maxwellian plasmas, such as might occur in beam-beam fusion concepts, are necessary to address fuels like p-{sup 11}B which have the added advantages of a more aneutronic character and plentiful fuel supply. Such plasmas appear very difficult to achieve but several possible approaches such as electrostatic confinement are noted. 52 refs., 13 figs, 5 tabs.

  8. Interplanetary propulsion using inertial fusion

    NASA Technical Reports Server (NTRS)

    Orth, C. D.; Hogan, W. J.; Hoffman, N.; Murray, K.; Klein, G.; Diaz, F. C.

    1987-01-01

    Inertial fusion can be used to power spacecraft within the solar system and beyond. Such spacecraft have the potential for short-duration manned-mission performance exceeding other technologies. We are conducting a study to assess the systems aspects of inertial fusion as applied to such missions, based on the conceptual engine design of Hyde (1983) we describe the required systems for an entirely new spacecraft design called VISTA that is based on the use of DT fuel. We give preliminary design details for the power conversion and power conditioning systems for manned missions to Mars of total duration of about 100 days. Specific mission performance results will be published elsewhere, after the study has been completed.

  9. Possible theories of cold fusion

    Microsoft Academic Search

    M. Fleischmann; S. Pons; G. Preparata

    1994-01-01

    Summary  We review some of the key facts in the phenomenology of Pd-hydrides usually referred to as «cold fusion». We conclude that\\u000a all theoretical attempts that concentrate only on few-body interactions, both electromagnetic and nuclear, are probably insufficient\\u000a to explain such phenomena. On the other hand we find good indications that theories describing collective, coherent interactions\\u000a among elementary constituents leading tomacroscopic

  10. Maryland controlled fusion research program

    SciTech Connect

    Antonsen, T.M. Jr.; Drake, J.F.; Finn, J.M.; Guzdar, P.; Hassam, A.; Liu, C.S.; Ott, E.; Kleva, R.; Waelbroeck, F.

    1991-01-01

    In recent years, members of the Maryland Plasma Theory Group have made significant contributions to the national fusion theory program, and, in many cases, these theoretical developments helped to interpret experimental results and to design new experimental programs. In this paper, we summarize the technical progress in three major area: (1) L/H transition in tokamaks; (2) anomalous transport in tokamaks; (3) sawteeth and (4) magnetic reconnection in compact tori and RFP's.

  11. ACE Mission - Fusion and Nucleosynthesis

    NSDL National Science Digital Library

    This educational brief explains the idea that nuclear fusion is thought to be the mechanism by which virtually all of the elements around us are created. Topics include the proton-proton cycle, the carbon-nitrogen-oxygen cycle, and endothermic reactions in supernova explosions. There is also a discussion of the Advanced Composition Explorer (ACE), a spacecraft intended to study the origin and evolution of the elements produced by our Sun.

  12. Tally of Cold Fusion Papers

    Microsoft Academic Search

    Jed Rothwell

    2009-01-01

    This document contains a tally of cold fusion papers from two sources: the list maintained by Dieter Britz at Aarhus U., and the EndNote database used to generate the indexes at LENR-CANR.org. Various tallies such as the number of peer-reviewed experimental papers are presented. Purpose This report presents some background and a breakdown of the items in two databases of

  13. Heavy Ion Fusion Injector Program

    SciTech Connect

    Yu, S.; Eylon, S.; Chupp, W.W.

    1993-05-01

    A program is underway to construct a 2 MV, 800 mA, K{sup +} injector for heavy ion fusion. The Electrostatic Quadrupole (ESQ) injector configuration consists of a zeolite source, a diode of up to 1 MV, together with several electrostatic quadrupole units to simultaneously focus and accelerate the beam to 2 MV. The key issues of source technology, high voltage breakdown, beam aberrations, and transient effects will be discussed. Results from ongoing experiments and simulations will be presented.

  14. Fusion Frames Peter G. Casazza and Gitta Kutyniok

    E-print Network

    Kutyniok, Gitta

    Chapter 1 Fusion Frames Peter G. Casazza and Gitta Kutyniok Abstract Novel technological advances. Fusion frames, which can be regarded as frames of subspaces, do satisfy exactly those needs. They analyze, distributed processing, fusion coherence, fusion frame, fusion frame potential, isoclinic subspaces, mutually

  15. FUSION SYSTEMS FOR PROFINITE GROUPS RADU STANCU AND PETER SYMONDS

    E-print Network

    Symonds, Peter

    FUSION SYSTEMS FOR PROFINITE GROUPS RADU STANCU AND PETER SYMONDS Abstract. We introduce the notion of a pro-fusion system on a pro-p group, which generalizes the notion of a fusion system on a finite p-group. We also prove a version of Alperin's Fusion Theorem for pro-fusion systems. 1. Introduction Profinite

  16. Image Fusion schemes using ICA bases Nikolaos Mitianoudis, Tania Stathaki

    E-print Network

    Mitianoudis, Nikolaos

    Image Fusion schemes using ICA bases Nikolaos Mitianoudis, Tania Stathaki Communications and Signal Processing group, Imperial College London, Exhibition Road, SW7 2AZ London, UK Abstract Image fusion as analysis and synthesis tools for image fusion by the fusion community. Using various fusion rules, one can

  17. Gasdynamic Mirror Fusion Propulsion Experiment

    NASA Technical Reports Server (NTRS)

    Emrich, Bill; Rodgers, Stephen L. (Technical Monitor)

    2000-01-01

    A gasdynamic mirror (GDM) fusion propulsion experiment is currently being constructed at the NASA Marshall Space Flight Center (MSFC) to test the feasibility of this particular type of fusion device. Because of the open magnetic field line configuration of mirror fusion devices, they are particularly well suited for propulsion system applications since they allow for the easy ejection of thrust producing plasma. Currently, the MSFC GDM is constructed in three segments. The vacuum chamber mirror segment, the plasma injector mirror segment, and the main plasma chamber segment. Enough magnets are currently available to construct up to three main plasma chamber segments. The mirror segments are also segmented such that they can be expanded to accommodate new end plugging strategies with out requiring the disassembly of the entire mirror segment. The plasma for the experiment is generated in a microwave cavity located between the main magnets and the mirror magnets. Ion heating is accomplished through ambipolar diffusion. The objective of the experiment is to investigate the stability characteristics of the gasdynamic mirror and to map a region of parameter space within which the plasma can be confined in a stable steady state configuration. The mirror ratio, plasma density, and plasma "b" will be varied over a range of values and measurements subsequently taken to determine the degree of plasma stability.

  18. Magnetized target fusion ignition conditions

    SciTech Connect

    Peretti, M. de; Sabatier, M. [Centre d`Etudes de Limeil-Valenton, Villeneuve St. Georges (France)

    1995-12-31

    Magnetized Target Fusion (MTF) consists of the hydrodynamic compression of a wall, hot, magnetized DT plasma to ignition conditions. MTF takes advantage of two benefits of a magnetic field in a plasma: (1) reduction of the thermal conductivity and (2) enhancement of the charged particle reaction product energy deposition. To study the ignition conditions, the authors evaluate the gains brought by compression and fusion and losses dissipated by bremsstrahlung, compton, conduction and synchrotron. They are able to construct the boundaries for boot-strapping burn with or in absence (ICF) of magnetic field. They demonstrate that MTF ignition can occur using very low implosion velocities for plasmas with very low Rho-R and densities (by ICF standards). This is possible because the major heat loss mechanism, thermal conduction is suppressed by mega-gauss fields and the DT alpha particles are partially trapped within the plasma. They prove, unlike ICF, that the fusion region for MTF is sensitive to the mass of the DT in the target. This sensitivity just reflects the fact that the additional physical processes involved in MTF don`t have the same dependence on density and target radius separately, so the equations don`t scale in such a simple way with Rho-R. For a target containing 10 mu-gm of DT, the MTF region is considerably smaller than for 100 mu-gm, and even the ICF region is hardly enlarged at all.

  19. Inertial fusion experiments and theory

    NASA Astrophysics Data System (ADS)

    Mima, Kunioki; Tikhonchuk, V.; Perlado, M.

    2011-09-01

    Inertial fusion research is approaching a critical milestone, namely the demonstration of ignition and burn. The world's largest high-power laser, the National Ignition Facility (NIF), is under operation at the Lawrence Livermore National Laboratory (LLNL), in the USA. Another ignition machine, Laser Mega Joule (LMJ), is under construction at the CEA/CESTA research centre in France. In relation to the National Ignition Campaign (NIC) at LLNL, worldwide studies on inertial fusion applications to energy production are growing. Advanced ignition schemes such as fast ignition, shock ignition and impact ignition, and the inertial fusion energy (IFE) technology are under development. In particular, the Fast Ignition Realization Experiment (FIREX) at the Institute of Laser Engineering (ILE), Osaka University, and the OMEGA-EP project at the Laboratory for Laser Energetics (LLE), University Rochester, and the HiPER project in the European Union (EU) for fast ignition and shock ignition are progressing. The IFE technology research and development are advanced in the frameworks of the HiPER project in EU and the LIFE project in the USA. Laser technology developments in the USA, EU, Japan and Korea were major highlights in the IAEA FEC 2010. In this paper, the status and prospects of IFE science and technology are described.

  20. Gasdynamic Mirror Fusion Propulsion Experiment

    NASA Technical Reports Server (NTRS)

    Emrich, William J., Jr.; Rodgers, Stephen L. (Technical Monitor)

    2001-01-01

    Nuclear fusion appears to be the most promising concept for producing extremely high specific impulse rocket engines. One particular fusion concept which seems to be particularly well suited for fusion propulsion applications is the gasdynamic mirror (GDM). This device would operate at much higher plasma densities and with much larger LD ratios than previous mirror machines. Several advantages accrue from such a design. First, the high LA:) ratio minimizes to a large extent certain magnetic curvature effects which lead to plasma instabilities causing a loss of plasma confinement. Second, the high plasma density will result in the plasma behaving much more Re a conventional fluid with a mean free path shorter than the length of the device. This characteristic helps reduce problems associated with "loss cone" microinstabilities. An experimental GDM device is currently being constructed at the NASA Marshall Space Flight Center to provide an initial assessment of the feasibility of this type of propulsion system. Initial experiments are expected to commence in the late fall of 2000.

  1. Fusion for Earth and Space

    SciTech Connect

    Williams, Pharis E

    2009-03-16

    The compact reactor concept (Williams, 2007) has the potential to provide clean, safe and unlimited supply of energy for Earth and Space applications. The concept is a potential fusion reactor wherein deuterium nuclei are preferentially fused into helium nuclei. Because the deuterium nuclei are preferentially fused into helium nuclei at temperatures and energies lower than specified by the standard model there is no harmful radiation as a byproduct of this fusion process. Therefore, a reactor using this reaction does not need any shielding to contain such radiation. The energy released from each reaction and the absence of shielding makes the deuterium-plus-deuterium-to-helium (DDH) reactor very compact when compared to other reactors, both fission and fusion types. Moreover, the potential energy output per reactor weight and the absence of harmful radiation makes the DDH reactor an ideal candidate for individual home and space power. The concept also would make it possible for each plant or remote location to have it's own power source, on site, without the need for a connection to the power grid. This would minimize, or eliminate, power blackouts. The concept could replace large fission reactors and fossil fuel power plants plus provide energy for ships, locomotives, trucks and autos. It would make an ideal source of energy for space power applications and for space propulsion.

  2. Is Fusion Inhibited for Weakly Bound Nuclei?

    SciTech Connect

    Takahashi, J.; Munhoz, M.; Szanto, E.M.; Carlin, N.; Added, N.; Suaide, A.A.; de Moura, M.M.; Liguori Neto, R.; Szanto de Toledo, A. [Universidade de Sao Paulo, Institute de Fisica, Departamento de Fisica Nuclear, Caixa Postal 66318, 05389-970 Sao Paulo, Sao Paulo, (Brasil)] [Universidade de Sao Paulo, Institute de Fisica, Departamento de Fisica Nuclear, Caixa Postal 66318, 05389-970 Sao Paulo, Sao Paulo, (Brasil); Canto, L.F. [Instituto de Fisica, Universidade Federal do Rio de Janeiro, Caixa Postal 68528, 21945-970 Rio de Janeiro, RJ, (Brasil)] [Instituto de Fisica, Universidade Federal do Rio de Janeiro, Caixa Postal 68528, 21945-970 Rio de Janeiro, RJ, (Brasil)

    1997-01-01

    Complete fusion of light radioactive nuclei is predicted to be hindered at near-barrier energies. This feature is investigated in the case of the least bound stable nuclei. Evaporation residues resulting from the {sup 6,7}Li+{sup 9}Be and {sup 6,7}Li+{sup 12}C fusion reactions have been measured in order to study common features in reactions involving light weakly bound nuclei. The experimental excitation functions revealed that the fusion cross section is significantly smaller than the total reaction cross section and also smaller than the fusion cross section expected from the available systematics. A clear correlation between the fusion probability and nucleon (cluster) separation energy has been established.The results suggest that the breakup process has a strong influence on the hindrance of the fusion cross section. {copyright} {ital 1996} {ital The American Physical Society}

  3. Fusion: an energy source for synthetic fuels

    SciTech Connect

    Fillo, J A; Powell, J; Steinberg, M

    1980-01-01

    The decreasing availability of fossil fuels emphasizes the need to develop systems which will produce synthetic fuel to substitute for and supplement the natural supply. An important first step in the synthesis of liquid and gaseous fuels is the production of hydrogen. Thermonuclear fusion offers an inexhaustible source of energy for the production of hydrogen from water. Depending on design, electric generation efficiencies of approx. 40 to 60% and hydrogen production efficiencies by high temperature electrolysis of approx. 50 to 70% are projected for fusion reactors using high temperature blankets. Fusion/coal symbiotic systems appear economically promising for the first generation of commercial fusion synfuels plants. Coal production requirements and the environmental effects of large-scale coal usage would be greatly reduced by a fusion/coal system. In the long term, there could be a gradual transition to an inexhaustible energy system based solely on fusion.

  4. Cell Fusion Connects Oncogenesis with Tumor Evolution.

    PubMed

    Zhou, Xiaofeng; Merchak, Kevin; Lee, Woojin; Grande, Joseph P; Cascalho, Marilia; Platt, Jeffrey L

    2015-07-01

    Cell fusion likely drives tumor evolution by undermining chromosomal and DNA stability and/or by generating phenotypic diversity; however, whether a cell fusion event can initiate malignancy and direct tumor evolution is unknown. We report that a fusion event involving normal, nontransformed, cytogenetically stable epithelial cells can initiate chromosomal instability, DNA damage, cell transformation, and malignancy. Clonal analysis of fused cells reveals that the karyotypic and phenotypic potential of tumors formed by cell fusion is established immediately or within a few cell divisions after the fusion event, without further ongoing genetic and phenotypic plasticity, and that subsequent evolution of such tumors reflects selection from the initial diverse population rather than ongoing plasticity of the progeny. Thus, one cell fusion event can both initiate malignancy and fuel evolution of the tumor that ensues. PMID:26066710

  5. EDITORIAL: Safety aspects of fusion power plants

    NASA Astrophysics Data System (ADS)

    Kolbasov, B. N.

    2007-07-01

    This special issue of Nuclear Fusion contains 13 informative papers that were initially presented at the 8th IAEA Technical Meeting on Fusion Power Plant Safety held in Vienna, Austria, 10-13 July 2006. Following recommendation from the International Fusion Research Council, the IAEA organizes Technical Meetings on Fusion Safety with the aim to bring together experts to discuss the ongoing work, share new ideas and outline general guidance and recommendations on different issues related to safety and environmental (S&E) aspects of fusion research and power facilities. Previous meetings in this series were held in Vienna, Austria (1980), Ispra, Italy (1983), Culham, UK (1986), Jackson Hole, USA (1989), Toronto, Canada (1993), Naka, Japan (1996) and Cannes, France (2000). The recognized progress in fusion research and technology over the last quarter of a century has boosted the awareness of the potential of fusion to be a practically inexhaustible and clean source of energy. The decision to construct the International Thermonuclear Experimental Reactor (ITER) represents a landmark in the path to fusion power engineering. Ongoing activities to license ITER in France look for an adequate balance between technological and scientific deliverables and complying with safety requirements. Actually, this is the first instance of licensing a representative fusion machine, and it will very likely shape the way in which a more common basis for establishing safety standards and policies for licensing future fusion power plants will be developed. Now that ITER licensing activities are underway, it is becoming clear that the international fusion community should strengthen its efforts in the area of designing the next generations of fusion power plants—demonstrational and commercial. Therefore, the 8th IAEA Technical Meeting on Fusion Safety focused on the safety aspects of power facilities. Some ITER-related safety issues were reported and discussed owing to their potential importance for the fusion power plant research programmes. The objective of this Technical Meeting was to examine in an integrated way all the safety aspects anticipated to be relevant to the first fusion power plant prototype expected to become operational by the middle of the century, leading to the first generation of economically viable fusion power plants with attractive S&E features. After screening by guest editors and consideration by referees, 13 (out of 28) papers were accepted for publication. They are devoted to the following safety topics: power plant safety; fusion specific operational safety approaches; test blanket modules; accident analysis; tritium safety and inventories; decommissioning and waste. The paper `Main safety issues at the transition from ITER to fusion power plants' by W. Gulden et al (EU) highlights the differences between ITER and future fusion power plants with magnetic confinement (off-site dose acceptance criteria, consequences of accidents inside and outside the design basis, occupational radiation exposure, and waste management, including recycling and/or final disposal in repositories) on the basis of the most recent European fusion power plant conceptual study. Ongoing S&E studies within the US inertial fusion energy (IFE) community are focusing on two design concepts. These are the high average power laser (HAPL) programme for development of a dry-wall, laser-driven IFE power plant, and the Z-pinch IFE programme for the production of an economically-attractive power plant using high-yield Z-pinch-driven targets. The main safety issues related to these programmes are reviewed in the paper `Status of IFE safety and environmental activities in the US' by S. Reyes et al (USA). The authors propose future directions of research in the IFE S&E area. In the paper `Recent accomplishments and future directions in the US Fusion Safety & Environmental Program' D. Petti et al (USA) state that the US fusion programme has long recognized that the S&E potential of fusion can be attained by prudent materials selecti

  6. D-Fusion: a Distinctive Fusion Calculus Michele Boreale1, Maria Grazia Buscemi2, and Ugo Montanari2

    E-print Network

    Parrow, Joachim

    D-Fusion: a Distinctive Fusion Calculus Michele Boreale1, Maria Grazia Buscemi2, and Ugo Montanari2 Informatica, Universit`a di Pisa, Italy. boreale@dsi.unifi.it {buscemi,ugo}@di.unipi.it Abstract. Fusion of a new calculus, D-Fusion, with two binders, and . We show that D-Fusion is strictly more expressive

  7. The ITERThe ITER eraera : the 10: the 10 yearyear roadmaproadmap for the French fusion programmefor the French fusion programme

    E-print Network

    (disruptions, dust / T inventory, high performance with metallic walls ...) · Predictive modelling of fusion in Rome H mode on AUGH mode on AUG 2010-2035 : The Fusion Energy Era of magnetic fusion research 2010-2035 : The Fusion Energy Era of magnetic fusion research ITER thermonuclear plasmasITER thermonuclear plasmas

  8. Some Calculations for Cold Fusion Superheavy Elements

    E-print Network

    Zhong, X H; Ning, P Z

    2004-01-01

    The Q value and optimal exciting energy of the hypothetical superheavy nuclei in cold fusion reaction are calculated with relativistic mean field model and semiemperical shell model mass equation(SSME) and the validity of the two models is tested. The fusion barriers are also calculated with two different models and reasonable results are obtained. The calculations can give useful references for the experiments in the superheavy nuclei synthesized in cold fusion reactions.

  9. Some Calculations for Cold Fusion Superheavy Elements

    E-print Network

    X. H. Zhong; L. Li; P. Z. Ning

    2004-10-18

    The Q value and optimal exciting energy of the hypothetical superheavy nuclei in cold fusion reaction are calculated with relativistic mean field model and semiemperical shell model mass equation(SSME) and the validity of the two models is tested. The fusion barriers are also calculated with two different models and reasonable results are obtained. The calculations can give useful references for the experiments in the superheavy nuclei synthesized in cold fusion reactions.

  10. On optimal track-to-track fusion

    Microsoft Academic Search

    K. C. Chang; R. K. Saha; Y. Bar-Shalom

    1997-01-01

    Track-to-track fusion is an important part in multisensor fusion. Much research has been done in this area. Chong et al. (1979, 1986, 1990) among others, presented an optimal fusion formula under an arbitrary communication pattern. This formula is optimal when the underlying systems are deterministic, i.e., the process noise is zero, or when full-rate communication (two sensors exchange information each

  11. Review of alternative concepts for magnetic fusion

    SciTech Connect

    Krakowski, R.A.; Miller, R.L.; Hagenson, R.L.

    1980-01-01

    Although the Tokamak represents the mainstay of the world's quest for magnetic fusion power, with the tandem mirror serving as a primary backup concept in the US fusion program, a wide range of alternative fusion concepts (AFC's) have been and are being pursued. This review presents a summary of past and present reactor projections of a majority of AFC's. Whenever possible, quantitative results are given.

  12. Fusion plasma research and education in Japan

    SciTech Connect

    Inoue, N. [Univ. of Tokyo (Japan). Faculty of Engineering

    1995-12-31

    Japanese fusion plasma research and education is reviewed by focusing on the activities promoted by the Ministry of Education, Science, Culture, and Sports (MOE). University fusion research is pursued by the academic interest and student education. A hierarchical structure of budget and manpower arrangement is observed. The small research groups of universities play the role of recruiting young students into the fusion and plasma society. After graduating the master course, most students are engaged by industries.

  13. Equivalence of data fusion and simultaneous retrieval

    NASA Astrophysics Data System (ADS)

    Ceccherini, Simone; Carli, Bruno; Raspollini, Piera

    2015-04-01

    A new method for the data fusion of atmospheric vertical profiles, referred to as complete fusion, is presented. The performance of the method is compared with that of weighted and arithmetic means using the measurements of the MIPAS instrument. The complete fusion perfectly reproduces the results of the simultaneous retrieval with equal error estimates and number of degrees of freedom, while arithmetic and weighted means have relatively low vertical resolution and differ from the simultaneous retrieval by more than their errors.

  14. Adaptive sensor fusion using genetic algorithms

    SciTech Connect

    Fitzgerald, D.S.; Adams, D.G.

    1994-08-01

    Past attempts at sensor fusion have used some form of Boolean logic to combine the sensor information. As an alteniative, an adaptive ``fuzzy`` sensor fusion technique is described in this paper. This technique exploits the robust capabilities of fuzzy logic in the decision process as well as the optimization features of the genetic algorithm. This paper presents a brief background on fuzzy logic and genetic algorithms and how they are used in an online implementation of adaptive sensor fusion.

  15. Charged-particle-beam fusion reactors

    Microsoft Academic Search

    Y. Oka; T. Yamaki

    1983-01-01

    The Nuclear Engineering Research Laboratory and the Dept. of Physics, Nagoya University, discuss the light ion-beam fusion reactor. The framework of a feasibility study of heavy-ion-beam fusion is being considered, and energy cost analysis, conceptual design of the HIBLIC-I, and an experimental program are discussed. A table shows the parameters of UTLIF(2) and ADLIB-1 light-ion-beam fusion reactors. A blanket design

  16. Conceptual Designs of Tokamak Fusion Reactors

    Microsoft Academic Search

    Yasushi SEKI

    1989-01-01

    Tokamak fusion reactor design studies conducted in JAERI with support from national laboratories, universities and industries in the fifteen years since 1973 to the present are described. These studies gave considerable impact on the national and international fusion programs.From the proposal of He-cooled Li0 blanket for fusion power reactor in 1973 to the most recent proposal of easily replaceable guard

  17. Signaling Mechanisms in Mammalian Myoblast Fusion

    NSDL National Science Digital Library

    Ashok Kumar (University of Louisville; School of Medicine REV)

    2013-04-23

    Skeletal muscles are formed by the fusion of multiple myoblasts during development. Myoblast fusion is also essential for the growth and repair of injured myofibers. Recent investigations have shown that the process of myoblast fusion involves the activation of several cell signaling pathways, including those mediated by nuclear factor ?B, mitogen-activated protein kinases, Wnt, calcineurin–nuclear factor of activated T cells c2, transforming growth factor–?–Smad4, and the Rho guanosine triphosphatases. In this Review, which contains 2 figures and 84 references, we summarize the mechanisms by which the activation of these signaling pathways stimulates myoblast fusion.

  18. Radiation hardening of diagnostics for fusion reactors

    SciTech Connect

    Baur, J.F.; Engholm, B.A.; Hacker, M.P.; Maya, I.; Miller, P.H.; Toffolo, W.E.; Wojtowicz, S.S.

    1981-12-01

    A list of the diagnostic systems presently used in magnetic confinement fusion experiments is compiled herein. The radiation-sensitive components are identified, and their locations in zones around the machine are indicated. A table of radiation sensitivities of components is included to indicate the data available from previous work in fission reactor, space probe, and defense-related programs. Extrapolation and application to hardening of fusion diagnostic systems requires additional data that are more specific to the fusion radiation environment and fusion components. A list is also given of present radiation-producing facilities where near-term screening tests of materials and components can be performed.

  19. Recurrent Gene Fusions in Prostate Cancer

    PubMed Central

    Kumar-Sinha, Chandan; Tomlins, Scott A.; Chinnaiyan, Arul M.

    2009-01-01

    The discovery of recurrent gene fusions in a majority of prostate cancers has important clinical and biological implications in the study of common epithelial tumors. Gene fusion and chromosomal rearrangements were previously thought to be the primary oncogenic mechanism of hematological malignancies and sarcomas. The prostate cancer gene fusions that have been identified thus far are characterized by 5’ genomic regulatory elements, most commonly controlled by androgen, fused to members of the ETS family of transcription factors, leading to the over-expression of oncogenic transcription factors. ETS gene fusions likely define a distinct class of prostate cancer which may have a bearing on diagnosis, prognosis and rational therapeutic targeting. PMID:18563191

  20. Mr. Fusion: A Programmable Data Fusion Middleware Subsystem with a Tunable Statistical Profiling Service

    Microsoft Academic Search

    Andy A. Franz; Radek Mista; David E. Bakken; Curtis E. Dyreson; Muralidhar Medidi

    2002-01-01

    Voting is the process of combining multiple replies from replicated servers into a single reply. Data fusion is similar to but more general than voting. In data fusion, the input sources are not necessarily replicated servers, hence the inputs exhibit greater variance. Data fusion is a fundamental building block in distributed systems. It occurs in diverse contexts such as consensus,

  1. Differential Cholesterol Binding by Class II Fusion Proteins Determines Membrane Fusion Properties

    Microsoft Academic Search

    M. Umashankar; C. Sanchez-San Martin; Maofu Liao; Brigid Reilly; Alice Guo; Gwen Taylor; Margaret Kielian

    2008-01-01

    Received 9 May 2008\\/Accepted 8 July 2008 The class II fusion proteins of the alphaviruses and flaviviruses mediate virus infection by driving the fusion of the virus membrane with that of the cell. These fusion proteins are triggered by low pH, and their structures are strikingly similar in both the prefusion dimer and the postfusion homotrimer conformations. Here we have

  2. Stochastic Fusion Simulations and Experiments Suggest Passive and Active Roles of Hemagglutinin during Membrane Fusion

    E-print Network

    Daniel, Susan

    Stochastic Fusion Simulations and Experiments Suggest Passive and Active Roles of Hemagglutinin during Membrane Fusion Donald W. Lee, Vikram Thapar, Paulette Clancy, and Susan Daniel* School the host cell cytoplasm by fusing the viral and host membrane together. Fusion is mediated by hemagglutinin

  3. A light water excess heat reaction suggests that cold fusion may be alkali-hydrogen fusion

    SciTech Connect

    Bush, R.T. (California State Polytechnic Univ., Pomona, CA (United States))

    1992-09-01

    This paper reports that Mills and Kneizys presented data in support of a light water excess heat reaction obtained with an electrolytic cell highly reminiscent of the Fleischmann-Pons cold fusion cell. The claim of Mills and Kneizys that their excess heat reaction can be explained on the basis of a novel chemistry, which supposedly also explains cold fusion, is rejected in favor of their reaction being, instead, a light water cold fusion reaction. It is the first known light water cold fusion reaction to exhibit excess heat, it may serve as a prototype to expand our understanding of cold fusion. From this new reactions are deduced, including those common to past cold fusion studies. This broader pattern of nuclear reactions is typically seen to involve a fusion of the nuclides of the alkali atoms with the simplest of the alkali-type nuclides, namely, protons, deuterons, and tritons. Thus, the term alkali-hydrogen fusion seems appropriate for this new type of reaction with three subclasses: alkali-hydrogen fusion, alkali-deuterium fusion, and alkali-tritium fusion. A new three-dimensional transmission resonance model (TRM) is sketched. Finally, preliminary experimental evidence in support of the hypothesis of a light water nuclear reaction and alkali-hydrogen fusion is reported. Evidence is presented that appears to strongly implicate the transmission resonance phenomenon of the new TRM.

  4. CCFE is the fusion research arm of the United Kingdom Atomic Energy Authority Fusion Technology at

    E-print Network

    CCFE is the fusion research arm of the United Kingdom Atomic Energy Authority Fusion Technology of engineering and technology within the roadmap to fusion · The importance of research partnerships · Key areas of interest for CCFE · Examples of current research at CCFE #12;PhD and Masters Open Day 15th November 2012

  5. Coded imaging of fusion neutrons in inertial confinement fusion experiments

    NASA Astrophysics Data System (ADS)

    Delage, Olivier; Savale, B.; Arsenault, Henri H.

    1998-12-01

    In Inertial Confinement Fusion (ICF) experiments, radiation from the compressed core is increasingly reabsorbed. For the largest experiments, the only radiation to escape is the 14 MeV fusion neutrons in which we must turn to learn of the physical processes taking place. The most important parameters are the shape and the size of the compressed core and this involves imaging the neutrons produced by the fusion reactions. The penumbral technique is ideally suited to neutron imaging and the feasibility of this technique has been demonstrated at the Lawrence Livermore National Laboratory in the United States. At the Phebus laser facility in France, this method has been used in image compressed ICF cores with diameters of 150 micrometers yielding approximately 109 neutrons, and the overall spatial resolution obtained in the reconstructed source was approximately 100 micrometers . On the Laser Megajoule project which is the equivalent of the National Ignition Facility in the United States, the spatial resolution required to diagnose high-convergence targets is 10 micrometers . We wish first to obtain a spatial resolution of 30 micrometers to image source with a diameter

  6. Fusion action systems by Matthew J.K. Gelvin.

    E-print Network

    Gelvin, Matthew J. K. (Matthew Justin Karcher)

    2010-01-01

    The study of fusion first arose in the local theory of finite groups. Puig abstracted the fusion data of a finite group to the notion of fusion system, an object that reflects local data in more abstract algebraic settings, ...

  7. 21 CFR 886.1880 - Fusion and stereoscopic target.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...2012-04-01 2012-04-01 false Fusion and stereoscopic target. 886.1880...DEVICES Diagnostic Devices § 886.1880 Fusion and stereoscopic target. (a) Identification. A fusion and stereoscopic target is a device...

  8. 21 CFR 886.1880 - Fusion and stereoscopic target.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...2013-04-01 2013-04-01 false Fusion and stereoscopic target. 886.1880...DEVICES Diagnostic Devices § 886.1880 Fusion and stereoscopic target. (a) Identification. A fusion and stereoscopic target is a device...

  9. 75 FR 8685 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ...DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY...This notice announces a meeting of the Fusion Energy Sciences Advisory Committee. The...CONTACT: Albert L. Opdenaker, Office of Fusion Energy Sciences; U.S. Department...

  10. 78 FR 2259 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ...DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY...This notice announces a meeting of the Fusion Energy Sciences Advisory Committee. The...Designated Federal Officer, Office of Fusion Energy Sciences; U.S. Department...

  11. 21 CFR 886.1880 - Fusion and stereoscopic target.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...2011-04-01 2011-04-01 false Fusion and stereoscopic target. 886.1880...DEVICES Diagnostic Devices § 886.1880 Fusion and stereoscopic target. (a) Identification. A fusion and stereoscopic target is a device...

  12. 21 CFR 886.1880 - Fusion and stereoscopic target.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...2010-04-01 2010-04-01 false Fusion and stereoscopic target. 886.1880...DEVICES Diagnostic Devices § 886.1880 Fusion and stereoscopic target. (a) Identification. A fusion and stereoscopic target is a device...

  13. 21 CFR 886.1880 - Fusion and stereoscopic target.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...2014-04-01 2014-04-01 false Fusion and stereoscopic target. 886.1880...DEVICES Diagnostic Devices § 886.1880 Fusion and stereoscopic target. (a) Identification. A fusion and stereoscopic target is a device...

  14. 76 FR 49757 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-11

    ...provides advice and recommendations to the Department of Energy on long-range plans, priorities, and strategies for advancing plasma science, fusion science, and fusion technology related to the Fusion Energy Sciences program. Additionally, the...

  15. Level 5 (User Refinement) issues supporting Information Fusion Management

    Microsoft Academic Search

    Erik Blasch

    2006-01-01

    Subsequent revisions to the Joint-Directors of Lab (JDL) model emphasize the differentiation between fusion (estimation) and sensor management (control). Two diverging groups include one pressing for fusion automation (JDL revisions) and one advocating the role of the user (user-fusion model). The center of debate is real-world delivery of fusion systems which requires presenting fusion results for knowledge representation (fusion estimation)

  16. Ch. 37, Inertial Fusion Energy Technology

    SciTech Connect

    Moses, E

    2010-06-09

    Nuclear fission, nuclear fusion, and renewable energy (including biofuels) are the only energy sources capable of satisfying the Earth's need for power for the next century and beyond without the negative environmental impacts of fossil fuels. Substantially increasing the use of nuclear fission and renewable energy now could help reduce dependency on fossil fuels, but nuclear fusion has the potential of becoming the ultimate base-load energy source. Fusion is an attractive fuel source because it is virtually inexhaustible, widely available, and lacks proliferation concerns. It also has a greatly reduced waste impact, and no danger of runaway reactions or meltdowns. The substantial environmental, commercial, and security benefits of fusion continue to motivate the research needed to make fusion power a reality. Replicating the fusion reactions that power the sun and stars to meet Earth's energy needs has been a long-sought scientific and engineering challenge. In fact, this technological challenge is arguably the most difficult ever undertaken. Even after roughly 60 years of worldwide research, much more remains to be learned. the magnitude of the task has caused some to declare that fusion is 20 years away, and always will be. This glib criticism ignores the enormous progress that has occurred during those decades, progress inboth scientific understanding and essential technologies that has enabled experiments producing significant amounts of fusion energy. For example, more than 15 megawatts of fusion power was produced in a pulse of about half a second. Practical fusion power plants will need to produce higher powers averaged over much longer periods of time. In addition, the most efficient experiments to date have required using about 50% more energy than the resulting fusion reaction generated. That is, there was no net energy gain, which is essential if fusion energy is to be a viable source of electricity. The simplest fusion fuels, the heavy isotopes of hydrogen (deuterium and tritium), are derived from water and the metal lithium, a relatively abundant resource. The fuels are virtually inexhaustible and they are available worldwide. Deuterium from one gallon of seawater would provide the equivalent energy of 300 gallons of gasoline, or over a half ton of coal. This energy is released when deuterium and tritium nuclei are fused together to form a helium nucleus and a neutron. The neutron is used to breed tritium from lithium. The energy released is carried by the helium nucleus (3.5 MeV) and the neutron (14 MeV). The energetic helium nucleus heats the fuel, helping to sustain the fusion reaction. Once the helium cools, it is collected and becomes a useful byproduct. A fusion power plant would produce no climate-changing gases.

  17. Magnetized Target Fusion in Advanced Propulsion Research

    NASA Technical Reports Server (NTRS)

    Cylar, Rashad

    2003-01-01

    The Magnetized Target Fusion (MTF) Propulsion lab at NASA Marshall Space Flight Center in Huntsville, Alabama has a program in place that has adopted to attempt to create a faster, lower cost and more reliable deep space transportation system. In this deep space travel the physics and development of high velocity plasma jets must be understood. The MTF Propulsion lab is also in attempt to open up the solar system for human exploration and commercial use. Fusion, as compared to fission, is just the opposite. Fusion involves the light atomic nuclei combination to produce denser nuclei. In the process, the energy is created by destroying the mass according to the distinguished equation: E = mc2 . Fusion energy development is being pursued worldwide as a very sustainable form of energy that is environmentally friendly. For the purposes of space exploration fusion reactions considered include the isotopes of hydrogen-deuterium (D2) and tritium (T3). Nuclei have an electrostatic repulsion between them and in order for the nuclei to fuse this repulsion must be overcome. One technique to bypass repulsion is to heat the nuclei to very high temperatures. The temperatures vary according to the type of reactions. For D-D reactions, one billion degrees Celsius is required, and for D-T reactions, one hundred million degrees is sufficient. There has to be energy input for useful output to be obtained form the fusion To make fusion propulsion practical, the mass, the volume, and the cost of the equipment to produce the reactions (generally called the reactor) need to be reduced by an order of magnitude or two from the state-of-the-art fusion machines. Innovations in fusion schemes are therefore required, especially for obtaining thrust for propulsive applications. Magnetized target fusion (MTF) is one of the innovative fusion concepts that have emerged over the last several years. MSFC is working with Los Alamos National Laboratory and other research groups in studying the underlying principles involved in MTF. Magnetized Target Fusion is an attempt to combine MCF (magnetic confinement fusion) for energy confinement and ICF (inertial confinement fusion) for efficient compression heating and wall free containment of the fusing plasma. It also seeks to combine the best features to these two main commonplace approaches to fusion.

  18. Magnetized Target Fusion Driven by Plasma Liners

    NASA Technical Reports Server (NTRS)

    Thio, Y. C. Francis; Kirkpatrick, Ronald C.; Knapp, Charles E.; Rodgers, Stephen L. (Technical Monitor)

    2002-01-01

    Magnetized target fusion is an emerging, relatively unexplored approach to fusion for electrical power and propulsion application. The physical principles of the concept are founded upon both inertial confinement fusion (ICF) and magnetic confinement fusion (MCF). It attempts to combine the favorable attributes of both these orthogonal approaches to fusion, but at the same time, avoiding the extreme technical challenges of both by exploiting a fusion regime intermediate between them. It uses a material liner to compress, heat and contain the fusion reacting plasma (the target plasma) mentally. By doing so, the fusion burn could be made to occur at plasma densities as high as six orders of magnitude higher than conventional MCF such as tokamak, thus leading to an approximately three orders of magnitude reduction in the plasma energy required for ignition. It also uses a transient magnetic field, compressed to extremely high intensity (100's T to 1000T) in the target plasma, to slow down the heat transport to the liner and to increase the energy deposition of charged-particle fusion products. This has several compounding beneficial effects. It leads to longer energy confinement time compared with conventional ICF without magnetized target, and thus permits the use of much lower plasma density to produce reasonable burn-up fraction. The compounding effects of lower plasma density and the magneto-insulation of the target lead to greatly reduced compressional heating power on the target. The increased energy deposition rate of charged-particle fusion products also helps to lower the energy threshold required for ignition and increasing the burn-up fraction. The reduction in ignition energy and the compressional power compound to lead to reduced system size, mass and R&D cost. It is a fusion approach that has an affordable R&D pathway, and appears attractive for propulsion application in the nearer term.

  19. Fusion Algebras of Logarithmic Minimal Models

    E-print Network

    Jorgen Rasmussen; Paul A. Pearce

    2007-09-21

    We present explicit conjectures for the chiral fusion algebras of the logarithmic minimal models LM(p,p') considering Virasoro representations with no enlarged or extended symmetry algebra. The generators of fusion are countably infinite in number but the ensuing fusion rules are quasi-rational in the sense that the fusion of a finite number of representations decomposes into a finite direct sum of representations. The fusion rules are commutative, associative and exhibit an sl(2) structure but require so-called Kac representations which are reducible yet indecomposable representations of rank 1. In particular, the identity of the fundamental fusion algebra is in general a reducible yet indecomposable Kac representation of rank 1. We make detailed comparisons of our fusion rules with the results of Gaberdiel and Kausch for p=1 and with Eberle and Flohr for (p,p')=(2,5) corresponding to the logarithmic Yang-Lee model. In the latter case, we confirm the appearance of indecomposable representations of rank 3. We also find that closure of a fundamental fusion algebra is achieved without the introduction of indecomposable representations of rank higher than 3. The conjectured fusion rules are supported, within our lattice approach, by extensive numerical studies of the associated integrable lattice models. Details of our lattice findings and numerical results will be presented elsewhere. The agreement of our fusion rules with the previous fusion rules lends considerable support for the identification of the logarithmic minimal models LM(p,p') with the augmented c_{p,p'} (minimal) models defined algebraically.

  20. Review of the magnetic fusion program by the 1986 ERAB Fusion Panel

    NASA Astrophysics Data System (ADS)

    Davidson, Ronald C.

    1987-09-01

    The 1986 ERAB Fusion Panel finds that fusion energy continues to be an attractive energy source with great potential for the future, and that the magnetic fusion program continues to make substantial technical progress. In addition, fusion research advances plasma physics, a sophisticated and useful branch of applied science, as well as technologies important to industry and defense. These factors fully justify the substantial expenditures by the Department of Energy in fusion research and development (R&D). The Panel endorses the overall program direction, strategy, and plans, and recognizes the importance and timeliness of proceeding with a burning plasma experiment, such as the proposed Compact Ignition Tokamak (CIT) experiment.