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Sample records for international study group

  1. International Study Tour Groups

    ERIC Educational Resources Information Center

    O'Reilly, Frances L.; Matt, John J.; McCaw, William P.; Kero, Patty; Stewart, Courtney; Haddouch, Reda

    2014-01-01

    Using the context of international study tour groups, this study examined the personal and professional transformation that occurred among host faculty and staff at The University of Montana-Missoula as a result of their interactions with traveling academics from other countries. Data were collected from participant responses (n = 27) using a…

  2. International scoping study: accelerator working group report

    SciTech Connect

    Zisman, Michael; Zisman, M.S.

    2006-09-30

    During the past several years, an International Scoping Study (ISS) of a Neutrino Factory was carried out, with the aim of developing an internationally accepted baseline facility design. Progress toward that goal will be described. Many of the key technical aspects of a Neutrino Factory facility design are presently being investigated experimentally, and the status of these investigations will be mentioned. Plans for the recently launched International Design Study (IDS), which serves as a follow-on to the ISS, will be briefly described.

  3. Microwave Study of a Hydrogen-Transfer Methyl-Group Internal Rotation in 5-METHYLTROPOLONE

    NASA Astrophysics Data System (ADS)

    Ilyushin, Vadim V.; Cloessner, Emily A.; Chou, Yung-Ching; Picraux, Laura B.; Hougen, Jon T.; Lavrich, Richard

    2010-06-01

    We present here the first experimental and theoretical study of the microwave spectrum of 5-methyltropolone, which can be visualized as a 7-membered "aromatic" carbon ring with a five-membered hydrogen-bonded cyclic structure at the top and a methyl group at the bottom. The molecule exhibits two large-amplitude motions, an intramolecular hydrogen transfer and a methyl torsion. The former motion is particularly interesting because transfer of the hydrogen atom from the hydroxyl to the carbonyl group induces a tautomerization in the molecule, which then triggers a 60° internal rotation of the methyl group. Measurements were carried out by Fourier-transform microwave spectroscopy in the 8 to 24 GHz frequency range. Theoretical analysis was carried out using a tunneling-rotational Hamiltonian based on a G12^m extended-group-theory formalism. Our global fit of 1015 transitions to 20 molecular parameters gave a root-mean-square deviation of 1.5 kHz. The tunneling splitting of the two J = 0 levels arising from a hypothetical pure hydrogen transfer motion is calculated to be 1310 MHz. The tunneling splitting of the two J = 0 levels arising from a hypothetical pure methyl-top internal rotation motion is calculated to be 885 MHz. Some theoretical difficulties in interpreting the low-order tunneling parameters in this and the related molecule 2-methylmalonaldehyde will be discussed.

  4. A Qualitative Study of the Use of Sand for Counselor Interns in Group Supervision: A Grounded Theory Approach

    ERIC Educational Resources Information Center

    Andrade, Helena Bohn

    2009-01-01

    The purpose of this study was to explore sandtray as a group supervision method in counselor education programs. The research centered on the personal growth and development of counselor interns as they conceptualized and reflected on cases during group supervision. Research questions guiding the process included: What is the experience of…

  5. Parametric approaches to quality-adjusted survival analysis. International Breast Cancer Study Group.

    PubMed

    Cole, B F; Gelber, R D; Anderson, K M

    1994-09-01

    We present a parametric methodology for performing quality-of-life-adjusted survival analysis using multivariate censored survival data. It represents a generalization of the nonparametric Q-TWiST method (Quality-adjusted Time without Symptoms and Toxicity). The event times correspond to transitions between states of health that differ in terms of quality of life. Each transition is governed by a competing risks model where the health states are the competing risks. Overall survival is the sum of the amount of time spent in each health state. The first step of the proposed methodology consists of defining a quality function that assigns a "score" to a life having given health state transitions. It is a composite measure of both quantity and quality of life. In general, the quality function assigns a small value to a short life with poor quality and a high value to a long life with good quality. In the second step, parametric survival models are fit to the data. This is done by repeatedly modeling the conditional cause-specific hazard functions given the previous transitions. Covariates are incorporated by accelerated failure time regression, and the model parameters are estimated by maximum likelihood. Lastly, the modeling results are used to estimate the expectation of quality functions. Standard errors and confidence intervals are computed using the bootstrap and delta methods. The results are useful for simultaneously evaluating treatments in terms of quantity and quality of life. To demonstrate the proposed methods, we perform an analysis of data from the International Breast Cancer Study Group Trial V, which compared short-duration chemotherapy versus long-duration chemotherapy in the treatment of node-positive breast cancer. The events studied are: (1) the end of treatment toxicity, (2) disease recurrence, and (3) overall survival. PMID:7981389

  6. Genetic modifiers of ambulation in the cooperative international Neuromuscular research group Duchenne natural history study

    PubMed Central

    Bello, Luca; Kesari, Akanchha; Gordish-Dressman, Heather; Cnaan, Avital; Morgenroth, Lauren P; Punetha, Jaya; Duong, Tina; Henricson, Erik K; Pegoraro, Elena; McDonald, Craig M; Hoffman, Eric P

    2015-01-01

    Objective We studied the effects of LTBP4 and SPP1 polymorphisms on age at loss of ambulation (LoA) in a multiethnic Duchenne muscular dystrophy (DMD) cohort. Methods We genotyped SPP1 rs28357094 and LTBP4 haplotype in 283 of 340 participants in the Cooperative International Neuromuscular Research Group Duchenne Natural History Study (CINRG-DNHS). Median ages at LoA were compared by Kaplan–Meier analysis and log-rank test. We controlled polymorphism analyses for concurrent effects of glucocorticoid corticosteroid (GC) treatment (time-varying Cox regression) and for population stratification (multidimensional scaling of genome-wide markers). Results Hispanic and South Asian participants (n = 18, 41) lost ambulation 2.7 and 2 years earlier than Caucasian subjects (p = 0.003, <0.001). The TG/GG genotype at SPP1 rs28357094 was associated to 1.2-year-earlier median LoA (p = 0.048). This difference was greater (1.9 years, p = 0.038) in GC-treated participants, whereas no difference was observed in untreated subjects. Cox regression confirmed a significant effect of SPP1 genotype in GC-treated participants (hazard ratio = 1.61, p = 0.016). LTBP4 genotype showed a direction of association with age at LoA as previously reported, but it was not statistically significant. After controlling for population stratification, we confirmed a strong effect of LTBP4 genotype in Caucasians (2.4 years, p = 0.024). Median age at LoA with the protective LTBP4 genotype in this cohort was 15.0 years, 16.0 for those who were treated with GC. Interpretation SPP1 rs28357094 acts as a pharmacodynamic biomarker of GC response, and LTBP4 haplotype modifies age at LoA in the CINRG-DNHS cohort. Adjustment for GC treatment and population stratification appears crucial in assessing genetic modifiers in DMD. PMID:25641372

  7. A Study of International Undergraduate Students Taking Online Courses: Group and Organizational Socialization Theory and Sense of Belonging

    ERIC Educational Resources Information Center

    Adams, Jacob Lyle

    2013-01-01

    Purpose: This study sought to (1) identify and describe the experiences of international students participating in U.S. cohort- and text-based asynchronous online courses and to 2) analyze perceptions of belonging/isolation within online environments through group and organizational socialization theory. Research Methods: Data from interviews with…

  8. Challenges and Opportunities for International Cooperative Studies in Pediatric Hematopoeitic Cell Transplantation: Priorities of the Westhafen Intercontinental Group

    PubMed Central

    Schultz, Rudolph Kirk R.; Baker, Kevin Scott; Boelens, Jaap J.; Bollard, Catherine M.; Egeler, R. Maarten; Cowan, Mort; Ladenstein, Ruth; Lankester, Arjan; Locatelli, Franco; Lawitschka, Anita; Levine, John E.; Loh, Mignon; Nemecek, Eneida; Niemeyer, Charlotte; Prasad, Vinod K.; Rocha, Vanderson; Shenoy, Shalini; Strahm, Brigitte; Veys, Paul; Wall, Donna; Bader, Peter; Grupp, Stephan A.; Pulsipher, Michael A.; Peters, Christina

    2014-01-01

    More than 20% of allogeneic hematopoietic cell transplantations (HCTs) are performed in children and adolescents at a large number of relatively small centers. Unlike adults, at least one-third of HCTs in children are performed for rare, nonmalignant indications. Clinical trials to improve HCT outcomes in children have been limited by small numbers and these pediatric-specific features. The need for a larger number of pediatric HCT centers to participate in trials has led to the involvement of international collaborative groups. Representatives of the Pediatric Blood and Marrow Transplant Consortium, European Group for Blood and Marrow Transplantation’s Pediatric Working Group, International Berlin-Frankfurt-Munster (iBFm) Stem Cell Transplantation Committee, and Children’s Oncology Group’s Hematopoietic Stem Cell Transplantation Discipline Committee met on October 3, 2012, in Frankfurt, Germany to develop a consensus on the highest priorities in pediatric HCT. In addition, it explored the creation of an international consortium to develop studies focused on HCT in children and adolescents. This meeting led to the creation of an international HCT network, dubbed the Westhafen Intercontinental Group, to develop worldwide priorities and strategies to address pediatric HCT issues. This review outlines the priorities of need as identified by this consensus group. PMID:23883618

  9. Renormalization group in internal space

    SciTech Connect

    Polonyi, J.; Sailer, K.

    2005-01-15

    Renormalization group in the internal space consists of the gradual change of the coupling constants. Functional evolution equations corresponding to the change of the mass or the coupling constant are presented in the framework of a scalar model. The evolution in the mass which yields the functional generalization of the Callan-Symanzik equation for the one-particle irreducible effective action is given in its renormalized, cutoff-independent form. The evolution of the coupling constant generates an evolution equation for the two-particle irreducible effective action.

  10. Backbone Relaxation Coupled to the Ionization of Internal Groups in Proteins: A Self-Guided Langevin Dynamics Study

    PubMed Central

    Damjanović, Ana; Wu, Xiongwu; García-Moreno E., Bertrand; Brooks, Bernard R.

    2008-01-01

    Pathways of structural relaxation triggered by ionization of internal groups in staphylococcal nuclease (SNase) were studied through multiple self-guided Langevin dynamics (SGLD) simulations. Circular dichroism, steady-state Trp fluorescence, and nuclear magnetic resonance spectroscopy have shown previously that variants of SNase with internal Glu, Asp, and Lys at positions 66 or 92, and Arg at position 66, exhibit local reorganization or global unfolding when the internal ionizable group is charged. Except for Arg-66, these internal ionizable groups have unusual pKa values and are neutral at physiological pH. The structural trends observed in the simulations are in general agreement with experimental observations. The I92D variant, which unfolds globally upon ionization of Asp-92, in simulations often exhibits extensive hydration of the protein core, and sometimes also significant perturbations of the β-barrel. In the crystal structure of the V66R variant, the β1 strand from the β-barrel is domain-swapped; in the simulations, the β1 strand is sometimes partially released. The V66K variant, which in solutions shows reorganization of six residues at the C-terminus of helix α1 and perturbations in the β-barrel structure, exhibits fraying of three residues of helix α1 in one simulation, and perturbations and partial unfolding of three β-strands in a few other simulations. In sharp contrast, very small structural changes were observed in simulations of the wild-type protein. The simulations indicate that charging of internal groups frequently triggers penetration of water into the protein interior. The pKa values of Asp-92 and Arg-66 calculated with continuum methods on SGLD-relaxed structures reached the normal values in most simulations. Detailed analysis of accuracy and performance of SGLD demonstrates that SGLD outperforms LD in sampling of alternative protein conformations without loss of the accuracy and level of detail characteristic of regular LD. PMID

  11. International Solar Cycle Studies [ISCS] Working Group 2: solar magnetic field variability - from the lower atmosphere through the inner corona

    NASA Astrophysics Data System (ADS)

    Harrison, Richard A.; Michels, Donald

    This report is a summary of activities and plans relating to the International Solar Cycle Studies (ISCS) Working Group 2, which is concerned with solar magnetic field variability, from the lower atmosphere through the inner corona. Whilst the Working Group carries a rather general title, the activities are focusing on several well defined topics - in particular the onset of coronal mass ejection events. Recognising the large number of scientific meetings worldwide, the working style of this group is aimed at improving communication, information exchange and collaboration making use of existing meetings and with a minimum of red tape. The core of the activity is through the use of the World Wide Web and e-mail. In this way, this Working Group does not introduce extra effort, but provides a better focus for on-going projects.

  12. Quality of life assessment in International Breast Cancer Study Group (IBCSG) trials: practical issues and factors associated with missing data.

    PubMed

    Bernhard, J; Peterson, H F; Coates, A S; Gusset, H; Isley, M; Hinkle, R; Gelber, R D; Castiglione-Gertsch, M; Hürny, C

    We report on our experience of quality of life (QL) assessment in adjuvant clinical trials of the International Breast Cancer Study Group (IBCSG), with special emphasis on cultural and logistical aspects of international organization that are unique to this group. Data are presented regarding submission rates of assessments before and after treatment failure, and timing of assessments relative to chemotherapy administration. To identify areas where rates might be improved, we investigated the association between missing data and sociodemographic and biomedical factors, treatment assignment, institution, chemotherapy compliance and toxicity in a trial of adjuvant chemoendocrine therapy for post-menopausal patients with breast cancer (IBCSG VII). The factors most highly associated with missing data were institution and chemotherapy compliance. PMID:9549808

  13. The International Thymic Malignancy Interest Group thymic initiative: a state-of-the-art study of thymic malignancies.

    PubMed

    Detterbeck, Frank; Korst, Robert

    2014-01-01

    Thymic malignancies are relatively rare tumors. A general lack of knowledge, misconceptions about benignancy, confusion about the definition of terms, and variability in reporting of outcomes have further hampered progress in these diseases. The International Thymic Malignancy Interest Group has emerged to counter these challenges and has brought together a worldwide multidisciplinary community determined to improve outcomes for these patients. Although the organization is young (initiated in 2010), major early accomplishments have created a foundation and infrastructure for scientific research. These include consensus definitions of terms, an unprecedented global database, development of practical clinical resources and, together with the International Association for the Study of Lung Cancer, development of proposals for the first formal stage classification of these malignant tumors. Many articles have been published or are under way, and a second phase of projects building on the early success is proceeding. The greatest accomplishment of the International Thymic Malignancy Interest Group lies in the establishment of an open culture of collaboration and the engagement of a broad group of individuals united by a common mission. It is a testament to what can be achieved, despite ongoing and inherent challenges, by determination and a collective effort. PMID:25837546

  14. Validation of cytogenetic risk groups according to International Prognostic Scoring Systems by peripheral blood CD34+FISH: results from a German diagnostic study in comparison with an international control group

    PubMed Central

    Braulke, Friederike; Platzbecker, Uwe; Müller-Thomas, Catharina; Götze, Katharina; Germing, Ulrich; Brümmendorf, Tim H.; Nolte, Florian; Hofmann, Wolf-Karsten; Giagounidis, Aristoteles A. N.; Lübbert, Michael; Greenberg, Peter L.; Bennett, John M.; Solé, Francesc; Mallo, Mar; Slovak, Marilyn L.; Ohyashiki, Kazuma; Le Beau, Michelle M.; Tüchler, Heinz; Pfeilstöcker, Michael; Nösslinger, Thomas; Hildebrandt, Barbara; Shirneshan, Katayoon; Aul, Carlo; Stauder, Reinhard; Sperr, Wolfgang R.; Valent, Peter; Fonatsch, Christa; Trümper, Lorenz; Haase, Detlef; Schanz, Julie

    2015-01-01

    International Prognostic Scoring Systems are used to determine the individual risk profile of myelodysplastic syndrome patients. For the assessment of International Prognostic Scoring Systems, an adequate chromosome banding analysis of the bone marrow is essential. Cytogenetic information is not available for a substantial number of patients (5%–20%) with dry marrow or an insufficient number of metaphase cells. For these patients, a valid risk classification is impossible. In the study presented here, the International Prognostic Scoring Systems were validated based on fluorescence in situ hybridization analyses using extended probe panels applied to cluster of differentiation 34 positive (CD34+) peripheral blood cells of 328 MDS patients of our prospective multicenter German diagnostic study and compared to chromosome banding results of 2902 previously published patients with myelodysplastic syndromes. For cytogenetic risk classification by fluorescence in situ hybridization analyses of CD34+ peripheral blood cells, the groups differed significantly for overall and leukemia-free survival by uni- and multivariate analyses without discrepancies between treated and untreated patients. Including cytogenetic data of fluorescence in situ hybridization analyses of peripheral CD34+ blood cells (instead of bone marrow banding analysis) into the complete International Prognostic Scoring System assessment, the prognostic risk groups separated significantly for overall and leukemia-free survival. Our data show that a reliable stratification to the risk groups of the International Prognostic Scoring Systems is possible from peripheral blood in patients with missing chromosome banding analysis by using a comprehensive probe panel (clinicaltrials.gov identifier:01355913). PMID:25344522

  15. Power Distance and Group Dynamics of an International Project Team: A Case Study

    ERIC Educational Resources Information Center

    Paulus, Trena M.; Bichelmeyer, Barbara; Malopinsky, Larissa; Pereira, Maura; Rastogi, Polly

    2005-01-01

    Project-based team activities are commonly used in higher education. Teams comprised of members from different national cultures can be faced with unique challenges during the creative process. Hofstede's (1991) cultural dimension of power distance was used to examine one such design team's intra- and inter-group interactions in a graduate-level…

  16. Childhood diabetes in Arab countries. Diabetes Epidemiology Research International Study Group.

    PubMed Central

    1990-01-01

    Insulin-dependent diabetes mellitus (IDDM) is a chronic disease of childhood that is associated with high costs, mortality and morbidity, but which is of unknown etiology. Globally, the incidence and prevalence of the disease are highly variable. Study of IDDM among Arab children, who have similar genetic characteristics, but markedly different environmental backgrounds, could provide important insight into its cause. Few studies of IDDM in Arab populations have been carried out, but the limited data available indicate that there are marked variations in the risk of the disease and in its distribution between the sexes. It is therefore very important that IDDM registries be established in Arab countries since this could lead to a greater understanding of the disease and perhaps its prevention. PMID:2364481

  17. Crystallographic Study of Hydration of an Internal Cavity in Engineered Proteins with Buried Polar or Ionizable Groups

    PubMed Central

    Schlessman, Jamie L.; Abe, Colby; Gittis, Apostolos; Karp, Daniel A.; Dolan, Michael A.; García-Moreno E., Bertrand

    2008-01-01

    Although internal water molecules are essential for the structure and function of many proteins, the structural and physical factors that govern internal hydration are poorly understood. We have examined the molecular determinants of internal hydration systematically, by solving the crystal structures of variants of staphylococcal nuclease with Gln-66, Asn-66, and Tyr-66 at cryo (100 K) and room (298 K) temperatures, and comparing them with existing cryo and room temperature structures of variants with Glu-66, Asp-66, Lys-66, Glu-92 or Lys-92 obtained under conditions of pH where the internal ionizable groups are in the neutral state. At cryogenic temperatures the polar moieties of all these internal side chains are hydrated except in the cases of Lys-66 and Lys-92. At room temperature the internal water molecules were observed only in variants with Glu-66 and Tyr-66; water molecules in the other variants are probably present but they are disordered and therefore undetectable crystallographically. Each internal water molecule establishes between 3 and 5 hydrogen bonds with the protein or with other internal water molecules. The strength of interactions between internal polar side chains and water molecules seems to decrease from carboxylic acids to amides to amines. Low temperature, low cavity volume, and the presence of oxygen atoms in the cavity increase the positional stability of internal water molecules. This set of structures and the physical insight they contribute into internal hydration will be useful for the development and benchmarking of computational methods for artificial hydration of pockets, cavities, and active sites in proteins. PMID:18178652

  18. Status and Plans for the Accelerator Working Group of the International Design Study of the Neutrino Factory

    SciTech Connect

    Berg, J. Scott

    2010-03-30

    The purpose of the International Design Study of the Neutrino Factory (IDS-NF) is to produce a design report for a neutrino factory in 2013. I report the status of the accelerator design and plans for future studies.

  19. Implementation of the International Association of Diabetes and Pregnancy Study Groups Criteria: Not Always a Cause for Concern

    PubMed Central

    Sibartie, Pooja; Quinlivan, Julie

    2015-01-01

    Background. Controversy surrounds the decision to adopt the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria for the diagnosis of gestational diabetes mellitus (GDM) as fears that disease prevalence rates will soar have been raised. Aims. To investigate the prevalence of pregnancy complicated with GDM before and after the introduction of the IADPSG 2010 diagnostic criteria. Materials and Methods. A prospective audit of all women who delivered from July 1, 2010, to June 30, 2014, in a predefined geographic region within the North Metropolitan Health Service of Western Australia. Women were diagnosed with GDM according to Australian Diabetes in Pregnancy Society (ADIPS 1991) criteria until December 31, 2011, and by the IADPSG 2010 criteria after this date. Incidence of GDM and predefined pregnancy outcomes were audited. Results. Of 10,296 women, antenatal oral glucose tolerance test (OGTT) results and follow-up data were obtained for 10,103 women (98%), of whom 349 (3.5%) were diagnosed with GDM. The rate of GDM utilising ADIPS criteria was 3.4% and the rate of utilising IADPSG criteria was 3.5% (p = 0.92). Conclusion. IADPSG diagnostic criteria did not significantly increase the incidence of GDM in this low prevalence region. PMID:26788370

  20. Critical Issues in International Group Counseling

    ERIC Educational Resources Information Center

    Bemak, Fred; Chung, Rita Chi-Ying

    2015-01-01

    Three-quarters of the world come from collectivistic group-oriented cultures. As the world becomes more globalized it is inevitable that group counseling will be a major choice of healing and psychological intervention internationally. However, a review of scholarly articles from "The Journal for Specialists in Group Work" and…

  1. Comparison of remifentanil versus regional anaesthesia in children anaesthetised with isoflurane/nitrous oxide. International Remifentanil Paediatric Anaesthesia Study group.

    PubMed

    Prys-Roberts, C; Lerman, J; Murat, I; Taivainen, T; Lopez, T; Lejus, C; Spahr-Schopfer, I; Splinter, W; Kirkham, A J

    2000-09-01

    We compared the efficacy and safety of a remifentanil (0.25 microg x kg(-1) x min(-1)-based balanced anaesthetic technique with a bupivacaine-based regional anaesthetic technique in an open label, multicentre study in 271 ASA physical status 1 or 2 children aged 1-12 years. Subjects requiring major intra-abdominal, urological or orthopaedic surgery were randomly allocated to receive either intravenous remifentanil (group R; n = 185) or epidural bupivacaine (group B; n = 86) with isoflurane/nitrous oxide for their anaesthesia. The majority of children in both groups (85% in group R, 78% in group B) showed no defined response to skin incision, and although the mean increase in systolic blood pressure (+11 mm Hg) was significantly greater in group R than in group B, this change did not represent a serious haemodynamic disturbance. More children in group R (31%) required interventions to treat hypotension and/or bradycardia than those in group B (12%), but these were easily managed by administration of fluids or anticholinergic drugs. Adverse events, mainly nausea and/or vomiting, occurred in 45% of group R and 42% of group B (NS). The adverse event profile of remifentanil in this study was typical of a potent mu-opioid receptor agonist. Remifentanil was as effective as epidural or caudal block in providing analgesia and suppressing physiological responses to surgical stimuli in children aged between 1 and 12 years undergoing major abdominal, urological, or orthopaedic surgery under isoflurane/nitrous oxide anaesthesia. PMID:10947750

  2. Parenting, identity development, internalizing symptoms, and alcohol use: a cross-sectional study in a group of Italian adolescents

    PubMed Central

    Pellerone, Monica; Tolini, Giacomo; Polopoli, Caterina

    2016-01-01

    Background Literature has demonstrated the adaptive function of identity development and parenting toward manifestation of problem behaviors in adolescence. These dimensions act on both internalizing and externalizing symptoms. Methods The objective is to investigate the relationship between identity status, parenting, and adolescent problems, which may manifest through internalized (phobias, obsessions, depression, eating disorders, entropy) and externalized modes (alcohol use and school discomfort). The research involved 198 Italian students (104 males and 94 females) in the 4th year (mean =16.94 years, standard deviation =0.35) and 5th year (mean =17.94 years, standard deviation =0.43) of senior secondary schools, who live in Caltanissetta, a town located in Sicily, Italy. The research lasted for 1 school year. The general group consisted of 225 students with a mortality rate of 12%. They completed an anamnestic questionnaire to provide 1) basic information, 2) alcohol consumption attitude in the past 30 days, and 3) their beliefs about alcohol; the “Ego Identity Process Questionnaire” to investigate identity development; the “Parental Bonding Instrument” to measure the perception of parenting during childhood; and the “Constraints of Mind” to value the presence of internalizing symptoms. Results Data show that identity status influences alcohol consumption. Low-profile identity and excessive maternal control affect the relational dependence and the tendency to perfectionism in adolescents. Among the predictors of alcohol use, there are socioeconomic status, parental control, and the presence of internalizing symptoms. Conclusion Family is the favored context of learning beliefs, patterns, and values that affect the broader regulatory social environment, and for this reason, it is considered the privileged context on which to intervene to reduce the adolescents’ behavior problems. This deviance could be an external manifestation of the difficulty

  3. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group.

    PubMed

    Fukuda, K; Straus, S E; Hickie, I; Sharpe, M C; Dobbins, J G; Komaroff, A

    1994-12-15

    The complexities of the chronic fatigue syndrome and the methodologic problems associated with its study indicate the need for a comprehensive, systematic, and integrated approach to the evaluation, classification, and study of persons with this condition and other fatiguing illnesses. We propose a conceptual framework and a set of guidelines that provide such an approach. Our guidelines include recommendations for the clinical evaluation of fatigued persons, a revised case definition of the chronic fatigue syndrome, and a strategy for subgrouping fatigued persons in formal investigations. PMID:7978722

  4. International Group Heterogeneity and Students' Business Project Achievement

    ERIC Educational Resources Information Center

    Ding, Ning; Bosker, Roel J.; Xu, Xiaoyan; Rugers, Lucie; van Heugten, Petra PAM

    2015-01-01

    In business higher education, group project work plays an essential role. The purpose of the present study is to explore the relationship between the group heterogeneity of students' business project groups and their academic achievements at both group and individual levels. The sample consists of 536 freshmen from an International Business School…

  5. Impact of International Foundations on the Internationalization of Chinese Research Universities: A Case Study of Peking University and the Nippon Foundation Group

    ERIC Educational Resources Information Center

    Yu, Zhan

    2010-01-01

    This study investigates two cooperative programs made by Peking University, a leading Chinese research university and the Nippon Foundation Group, an international foundation based in Japan. It attempts to examine the process through which the University collaborates with the Foundation, and explore to what extent the cooperation influenced the…

  6. Spin filtering in a double quantum dot device: Numerical renormalization group study of the internal structure of the Kondo state

    SciTech Connect

    Vernek, E.; Büsser, C. A.; Anda, E. V.; Feiguin, A. E.; Martins, G. B.

    2014-03-31

    A double quantum dot device, connected to two channels that only interact through interdot Coulomb repulsion, is analyzed using the numerical renormalization group technique. Using a two-impurity Anderson model, and realistic parameter values [S. Amasha, A. J. Keller, I. G. Rau, A. Carmi, J. A. Katine, H. Shtrikman, Y. Oreg, and D. Goldhaber-Gordon, Phys. Rev. Lett. 110, 046604 (2013)], it is shown that, by applying a moderate magnetic field and independently adjusting the gate potential of each quantum dot at half-filling, a spin-orbital SU(2) Kondo state can be achieved where the Kondo resonance originates from spatially separated parts of the device. Our results clearly link this spatial separation effect to currents with opposing spin polarizations in each channel, i.e., the device acts as a spin filter. In addition, an experimental probe of this polarization effect is suggested, pointing to the exciting possibility of experimentally probing the internal structure of an SU(2) Kondo state.

  7. International Space Station Earth Observations Working Group

    NASA Technical Reports Server (NTRS)

    Stefanov, William L.; Oikawa, Koki

    2015-01-01

    The multilateral Earth Observations Working Group (EOWG) was chartered in May 2012 in order to improve coordination and collaboration of Earth observing payloads, research, and applications on the International Space Station (ISS). The EOWG derives its authority from the ISS Program Science Forum, and a NASA representative serves as a permanent co-chair. A rotating co-chair position can be occupied by any of the international partners, following concurrence by the other partners; a JAXA representative is the current co-chair. Primary functions of the EOWG include, 1) the exchange of information on plans for payloads, from science and application objectives to instrument development, data collection, distribution and research; 2) recognition and facilitation of opportunities for international collaboration in order to optimize benefits from different instruments; and 3) provide a formal ISS Program interface for collection and application of remotely sensed data collected in response to natural disasters through the International Charter, Space and Major Disasters. Recent examples of EOWG activities include coordination of bilateral data sharing protocols between NASA and TsNIIMash for use of crew time and instruments in support of ATV5 reentry imaging activities; discussion of continued use and support of the Nightpod camera mount system by NASA and ESA; and review and revision of international partner contributions on Earth observations to the ISS Program Benefits to Humanity publication.

  8. 36Cl measurements in Hiroshima granite samples as part of an international intercomparison study. Results from the Munich group.

    PubMed

    Huber, T; Rühm, W; Hoshi, M; Egbert, S D; Nolte, E

    2003-04-01

    Within the effort to resolve the so-called Hiroshima neutron discrepancy, an international intercomparison study has been carried out on granite samples from Hiroshima, with participating institutions from Japan, the US, and Germany. (36)Cl and (152)Eu produced in these samples by thermal neutrons from the A-bomb explosion were assessed independently by means of different techniques. At the Maier-Leibnitz-Laboratory near Munich, Germany, (36)Cl concentrations were measured by accelerator mass spectrometry. Measured (36)Cl/Cl ratios ranged from 1,670 x 10(-13) (at a distance of 146 m from the hypocenter) to 2.2 x 10(-13) (at a distance of 1,163 m from the hypocenter). One granite sample not exposed to A-bomb neutrons was measured as a control, and a (36)Cl/Cl ratio of 2.6 x 10(-13) was obtained. On average, our experimental results are 20-30% lower than those provided by model calculations based on the dosimetry system DS86. The results presented here do not support previous assessments of (36)Cl, (60)Co, and (152)Eu which had suggested much larger thermal neutron fluences than those calculated on the basis of DS86 for distances from the hypocenter of more than 1,000 m. PMID:12684827

  9. Nineteenth International Microgravity Measurements Group Meeting

    NASA Technical Reports Server (NTRS)

    DeLombard, Richard (Compiler)

    2000-01-01

    The Microgravity Measurements Group meetings provide a forum for an exchange of information and ideas about various aspects of microgravity acceleration research in international microgravity research programs. These meetings are sponsored by the PI Microgravity Services (PIMS) project at the NASA Glenn Research Center. The 19th MGMG meeting was held 11-13 July 2000 at the Sheraton Airport Hotel in Cleveland, Ohio. The 44 attendees represented NASA, other space agencies, universities, and commercial companies; 8 of the attendees were international representatives from Japan, Italy, Canada, Russia, and Germany. Twenty-seven presentations were made on a variety of microgravity environment topics including the International Space Station (ISS), acceleration measurement and analysis results, science effects from microgravity accelerations, vibration isolation, free flyer satellites, ground testing, vehicle characterization, and microgravity outreach and education. The meeting participants also toured three microgravity-related facilities at the NASA Glenn Research Center. Contained within the minutes is the conference agenda, which indicates each speaker, the title of their presentation, and the actual time of their presentation. The minutes also include the charts for each presentation, which indicate the authors' name(s) and affiliation. In some cases, a separate written report was submitted and has been Included here

  10. NASA's Internal Space Weather Working Group

    NASA Technical Reports Server (NTRS)

    St. Cyr, O. C.; Guhathakurta, M.; Bell, H.; Niemeyer, L.; Allen, J.

    2011-01-01

    Measurements from many of NASA's scientific spacecraft are used routinely by space weather forecasters, both in the U.S. and internationally. ACE, SOHO (an ESA/NASA collaboration), STEREO, and SDO provide images and in situ measurements that are assimilated into models and cited in alerts and warnings. A number of years ago, the Space Weather laboratory was established at NASA-Goddard, along with the Community Coordinated Modeling Center. Within that organization, a space weather service center has begun issuing alerts for NASA's operational users. NASA's operational user community includes flight operations for human and robotic explorers; atmospheric drag concerns for low-Earth orbit; interplanetary navigation and communication; and the fleet of unmanned aerial vehicles, high altitude aircraft, and launch vehicles. Over the past three years we have identified internal stakeholders within NASA and formed a Working Group to better coordinate their expertise and their needs. In this presentation we will describe this activity and some of the challenges in forming a diverse working group.

  11. 17th International Microgravity Measurements Group Meeting

    NASA Technical Reports Server (NTRS)

    DeLombard, Richard

    1998-01-01

    The Seventeenth International Microgravity Measurements Group (MGMG) meeting was held 24-26 March 1998 at the Ohio Aerospace Institute (OAI) in Brook Park, Ohio. This meeting focused on the transition of microgravity science research from the Shuttle, Mir, and free flyers to the International Space Station. The MGMG series of meetings are conducted by the Principal Investigator Microgravity Services project of the Microgravity Science Division at the NASA Lewis Research Center. The MGMG meetings provide a forum for the exchange of information and ideas about the microgravity environment and microgravity acceleration research in the Microgravity Research Program. The meeting had participation from investigators in all areas of microgravity research. The attendees included representatives from: NASA centers; National Space Development Agency of Japan; European Space Agency; Daimler Benz Aerospace AG; Deutsches Zentrum fuer Luft- und Raumfahrt; Centre National d'Etudes Spatiales; Canadian Space Agency, national research institutions; Universities in U.S., Italy, Germany, and Russia; and commercial companies in the U.S. and Russia. Several agencies presented summaries of the measurement, analysis, and characterization of the microgravity environment of the Shuttle, Mir, and sounding rockets over the past fifteen years. This extensive effort has laid a foundation for pursuing a similar course during future microgravity science experiment operations on the ISS. Future activities of microgravity environment characterization were discussed by several agencies who plan to operate on the ISS.

  12. Group theories: relevance to group safety studies.

    PubMed

    Benevento, A L

    1998-01-01

    Promoting safety in the workplace has been attempted in a variety of ways. Increasingly, industries are using groups such as safety teams and quality circles to promote worker safety. Group influences on individual behavior and attitudes have long been studied in the social psychology literature, but the theories have not been commonly found outside the psychology arena. This paper describes the group theories of group polarization, risky shift, social loafing, groupthink and team think and attempts to apply these theories to existing studies that examine work group influences on safety. Interesting parallels were found but only one study examined group influences as their primary focus of research. Since groups are increasingly used for safety promotion, future research on safety that studies group influences with respect to current group theories is recommended. PMID:24441299

  13. Evaluation of an algorithm for the treatment of persistent diarrhoea: a multicentre study. International Working Group on Persistent Diarrhoea.

    PubMed Central

    1996-01-01

    Described are the findings of a multicentre cohort study to test an algorithm for the treatment of persistent diarrhoea relying on the use of locally available, inexpensive foods, vitamin and mineral supplementation, and the selective use of antibiotics to treat associated infections. The initial diet (A) contained cereals, vegetable oil, and animal milk or yoghurt. The diet (B) offered when the patient did not improve with the initial regimen was lactose free, and the energy from cereals was partially replaced by simple sugars. A total of 460 children with persistent diarrhoea, aged 4-36 months, were enrolled at study centres in Bangladesh, India, Mexico, Pakistan, Peru, and Viet Nam. The study population was young (11.5 +/- 5.7 months) and malnourished (mean weight-for-age Z-score, -3.03 +/- 0.86), and severe associated conditions were common (45% required rehydration or treatment of severe infections on admission). The overall success rate of the treatment algorithm was 80% (95% CI, 76-84%). The recovery rate among all children with only diet A was 65% (95% CI, 61-70%), and was 71% (95% CI, 62-81%) for those evaluated after receiving diet B. The children at the greatest risk for treatment failure were those who had acute associated illnesses (including cholera, septicaemia, and urinary tract infections), required intravenous antibiotics, and had the highest initial purging rates. Our results indicate that the short-term treatment of persistent diarrhoea can be accomplished safely and effectively, in the majority of patients, using an algorithm relying primarily on locally available foods and simple clinical guidelines. This study should help establish rational and effective treatment for persistent diarrhoea. PMID:9002328

  14. Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study

    PubMed Central

    Jenum, Anne K; Mørkrid, Kjersti; Sletner, Line; Vange, Siri; Torper, Johan L; Nakstad, Britt; Voldner, Nanna; Rognerud-Jensen, Odd H; Berntsen, Sveinung; Mosdøl, Annhild; Skrivarhaug, Torild; Vårdal, Mari H; Holme, Ingar; Yajnik, Chittaranjan S; Birkeland, Kåre I

    2012-01-01

    Objective The International Association of Diabetes and Pregnancy Study Groups (IADPSG) recently proposed new criteria for diagnosing gestational diabetes mellitus (GDM). We compared prevalence rates, risk factors, and the effect of ethnicity using the World Health Organization (WHO) and modified IADPSG criteria. Methods This was a population-based cohort study of 823 (74% of eligible) healthy pregnant women, of whom 59% were from ethnic minorities. Universal screening was performed at 28±2 weeks of gestation with the 75 g oral glucose tolerance test (OGTT). Venous plasma glucose (PG) was measured on site. GDM was diagnosed as per the definition of WHO criteria as fasting PG (FPG) ≥7.0 or 2-h PG ≥7.8 mmol/l; and as per the modified IADPSG criteria as FPG ≥5.1 or 2-h PG ≥8.5 mmol/l. Results OGTT was performed in 759 women. Crude GDM prevalence was 13.0% with WHO (Western Europeans 11%, ethnic minorities 15%, P=0.14) and 31.5% with modified IADPSG criteria (Western Europeans 24%, ethnic minorities 37%, P< 0.001). Using the WHO criteria, ethnic minority origin was an independent predictor (South Asians, odds ratio (OR) 2.24 (95% confidence interval (CI) 1.26–3.97); Middle Easterners, OR 2.13 (1.12–4.08)) after adjustments for age, parity, and prepregnant body mass index (BMI). This increased OR was unapparent after further adjustments for body height (proxy for early life socioeconomic status), education and family history of diabetes. Using the modified IADPSG criteria, prepregnant BMI (1.09 (1.05–1.13)) and ethnic minority origin (South Asians, 2.54 (1.56–4.13)) were independent predictors, while education, body height and family history had little impact. Conclusion GDM prevalence was overall 2.4-times higher with the modified IADPSG criteria compared with the WHO criteria. The new criteria identified many subjects with a relatively mild increase in FPG, strongly associated with South Asian origin and prepregnant overweight. PMID:22108914

  15. International neurocognitive normative study: neurocognitive comparison data in diverse resource-limited settings: AIDS Clinical Trials Group A5271.

    PubMed

    Robertson, K; Jiang, H; Evans, S R; Marra, C M; Berzins, B; Hakim, J; Sacktor, N; Silva, M Tulius; Campbell, T B; Nair, A; Schouten, J; Kumwenda, J; Supparatpinyo, K; Tripathy, S; Kumarasamy, N; la Rosa, A; Montano, S; Mwafongo, A; Firnhaber, C; Sanne, I; Naini, L; Amod, F; Walawander, A

    2016-08-01

    Infrastructure for conducting neurological research in resource-limited settings (RLS) is limited. The lack of neurological and neuropsychological (NP) assessment and normative data needed for clinical interpretation impedes research and clinical care. Here, we report on ACTG 5271, which provided neurological training of clinical site personnel and collected neurocognitive normative comparison data in diverse settings. At ten sites in seven RLS countries, we provided training for NP assessments. We collected normative comparison data on HIV- participants from Brazil (n = 240), India (n = 480), Malawi (n = 481), Peru (n = 239), South Africa (480), Thailand (n = 240), and Zimbabwe (n = 240). Participants had a negative HIV test within 30 days before standardized NP exams were administered at baseline and 770 at 6 months. Participants were enrolled in eight strata, gender (female and male), education (<10 and ≥10 years), and age (<35 and ≥35 years). Of 2400 enrolled, 770 completed the 6-month follow-up. As expected, significant between-country differences were evident in all the neurocognitive test scores (p < 0.0001). There was variation between the age, gender, and education strata on the neurocognitive tests. Age and education were important variables for all tests; older participants had poorer performance, and those with higher education had better performance. Women had better performance on verbal learning/memory and speed of processing tests, while men performed better on motor tests. This study provides the necessary neurocognitive normative data needed to build infrastructure for future neurological and neurocognitive studies in diverse RLS. These normative data are a much-needed resource for both clinicians and researchers. PMID:26733457

  16. Evaluation of the prevalence of gestational diabetes mellitus in North Indians using the International Association of Diabetes and Pregnancy Study groups (IADPSG) criteria

    PubMed Central

    Gopalakrishnan, V; Singh, R; Pradeep, Y; Kapoor, D; Rani, AK; Pradhan, S; Bhatia, E; Yadav, SB

    2015-01-01

    Objective: Currently, there is controversy regarding the diagnosis of gestational diabetes mellitus (GDM) as per the newer International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. We studied the prevalence and associations of GDM in North Indians, diagnosed by the IADPSG criteria. Patients and Methods: We conducted a cross-sectional study on 332 pregnant women, predominantly belonging to lower and middle socioeconomic strata. The women were screened for GDM between 24 weeks and 28 weeks of gestation by 75g oral glucose tolerance test (OGTT) and GDM diagnosed by the IADPSG criteria. Results: The prevalence of GDM was 41.9% [95% Confidence interval (CI) 36.6-47.2%]. Amongst the women diagnosed to have GDM, 91.4% had abnormal fasting plasma glucose (FPG), while 1-h and 2-h post-glucose (PG) levels were abnormal in 18.7% and 17.3% of women, respectively. No maternal factors were significantly associated with GDM. Birth weight of the neonates was similar in women with GDM as compared to those with normal glucose tolerance. In the entire group, fasting glucose levels were associated with the weight of the patient while 1-h PG levels were associated with weight, height, socioeconomic score, and parity. Conclusions: There is a very high prevalence rate of GDM using the IADPSG criteria in North Indian women of low and middle socioeconomic strata. Further studies are needed to assess the utility of applying these criteria in settings with limited resources. PMID:26119433

  17. Asian international students' barriers to joining group counseling.

    PubMed

    Lee, Ji-Yeon

    2014-10-01

    This cross-sectional study examined anticipated reactions to group participation among Asian international students (ISs). Structural equation modeling confirmed that Asian ISs' (n = 180) level of acculturation was associated with their attitude toward joining group counseling, which is partially mediated by their stigma toward help-seeking. The results of multiple regression analyses indicated that ISs who reported higher place dependence, stigma toward help-seeking, and fear of negative evaluation reported more fear about disclosing emotional parts of themselves to other group members in the presence of a group member from the same country of origin. The results showed that ISs' perceived difficulties in providing feedback to a group member in the presence of an IS from the same country of origin were predicted by low place identity, high place dependence, and more stigma. International students' willingness to disclose and provide feedback in a group counseling setting was compared in three different hypothetical situations based on other group members' demographics, and the results showed that ISs are more afraid of self-disclosure in the presence of an international student from the same country. PMID:25188562

  18. Second non-breast primary cancer following adjuvant therapy for early breast cancer: A report from the International Breast Cancer Study Group

    PubMed Central

    Gianni, Lorenzo; Gelber, Shari; Ravaioli, Alberto; Price, Karen N.; Panzini, Ilaria; Fantini, Manuela; Castiglione-Gertsch, Monica; Pagani, Olivia; Simoncini, Edda; Gelber, Richard D.; Coates, Alan S.; Goldhirsch, Aron

    2009-01-01

    The incidence of second non-breast primary cancer following adjuvant treatment was evaluated using data from patients enrolled from 1978 to 1999 in four International Breast Cancer Study Group (IBCSG) trials. The occurrence of these tumours as sites of first failure was assessed separately for two treatment comparisons: toremifene versus tamoxifen for five years in 1035 patients in IBCSG Trials 12-93 and 14-93 with a median follow-up of eight years and endocrine therapy (toremifene or tamoxifen) versus chemoendocrine therapy (CMF or AC plus toremifene or tamoxifen) in 1731 patients from IBCSG Trials III, VII and 12-93, with a combined median follow-up of 14 years. No significant differences in second non-breast primary tumours were observed in either comparison. In particular the incidences of second primary uterine tumours with toremifene and tamoxifen were similar and no significant increase of secondary leukaemias was observed with chemoendocrine therapy compared with endocrine therapy. PMID:19062268

  19. Simulation in International Studies

    ERIC Educational Resources Information Center

    Boyer, Mark A.

    2011-01-01

    Social scientists have long worked to replicate real-world phenomena in their research and teaching environments. Unlike our biophysical science colleagues, we are faced with an area of study that is not governed by the laws of physics and other more predictable relationships. As a result, social scientists, and international studies scholars more…

  20. Study Canada: International Outlook.

    ERIC Educational Resources Information Center

    Monahan, Robert L.; And Others

    This self-contained unit of study on Canada is one of a series which can be used to supplement secondary level courses of social studies, contemporary world problems, government, history, and geography. Developed by teachers, the unit focuses on international relations. A comparative approach is used which stresses understanding Canada from…

  1. Modern International Research Groups: Networks and Infrastructure

    NASA Astrophysics Data System (ADS)

    Katehi, Linda

    2009-05-01

    In a globalized economy, education and research are becoming increasing international in content and context. Academic and research institutions worldwide try to internationalize their programs by setting formal or informal collaborations. An education that is enhanced by international experiences leads to mobility of the science and technology workforce. Existing academic cultures and research structures are at odds with efforts to internationalize education. For the past 20-30 years, the US has recognized the need to improve the abroad experience of our scientists and technologists: however progress has been slow. Despite a number of both federally and privately supported programs, efforts to scale up the numbers of participants have not been satisfactory. The exchange is imbalanced as more foreign scientists and researchers move to the US than the other way around. There are a number of issues that contribute to this imbalance but we could consider the US academic career system, as defined by its policies and practices, as a barrier to internationalizing the early career faculty experience. Strict curricula, pre-tenure policies and financial commitments discourage students, post doctoral fellows and pre-tenure faculty from taking international leaves to participate in research abroad experiences. Specifically, achieving an international experience requires funding that is not provided by the universities. Furthermore, intellectual property requirements and constraints in pre-tenure probationary periods may discourage students and faculty from collaborations with peers across the Atlantic or Pacific or across the American continent. Environments that support early career networking are not available. This presentation will discuss the increasing need for international collaborations and will explore the need for additional programs, more integration, better conditions and improved infrastructures that can encourage and support mobility of scientists. In addition

  2. Multicenter study of street foods in 13 towns on four continents by the food and environmental hygiene study group of the international network of pasteur and associated institutes.

    PubMed

    Garin, B; Aïdara, A; Spiegel, A; Arrive, P; Bastaraud, A; Cartel, J L; Aissa, R Ben; Duval, P; Gay, M; Gherardi, C; Gouali, M; Karou, T G; Kruy, S L; Soares, J L; Mouffok, F; Ravaonindrina, N; Rasolofonirina, N; Pham, M T; Wouafo, M; Catteau, M; Mathiot, C; Mauclere, P; Rocourt, J

    2002-01-01

    An international multicenter study of ready-to-eat foods, sandwiches, and ice creams or sorbets sold in the streets and their vendors was carried out to assess the microbiological quality of these foods and to identify characteristics of the vendors possibly associated with pathogens. Thirteen towns in Africa, America, Asia, and Oceania were involved in the study. A single protocol was used in all 13 centers: representative sampling was by random selection of vendors and a sample of foods bought from each of these vendors at a time and date selected at random. Microbiological analyses were carried out using standardized Association Française de Normalisation methods, and the use of a standardized questionnaire to collect data concerning the characteristics of the vendors. Fifteen surveys were carried out, with 3,003 food samples from 1,268 vendors. The proportion of unsatisfactory food samples was between 12.7 and 82.9% for ice creams and sorbets and between 11.3 and 92% for sandwiches. For ice creams and sorbets, the sale of a large number of units (>80 per day) increased the risk of unsatisfactory food by a factor of 2.8 (95% confidence interval [CI]: 1.5 to 5.1), lack of training in food hygiene by 6.6 (95% CI: 1.1 to 50). and by a factor of 2.8 (95% CI: 1.4 to 5.4) for mobile vendors. These risk factors were not identified for sandwiches, this difference may be due to the presence of a cooking step in their preparation. These results show that the poor microbiological quality of these street foods constitutes a potential hazard to public health, that the extent of this hazard varies between the cities studied, and that vendors' health education in food safety is a crucial factor in the prevention of foodborne infections. PMID:11808786

  3. Functional Imaging Using 18-Fluorodeoxyglucose PET in the Management of Primary Mediastinal Large B-Cell Lymphoma: The Contributions of the International Extranodal Lymphoma Study Group.

    PubMed

    Cavalli, Franco; Ceriani, Luca; Zucca, Emanuele

    2016-01-01

    Primary mediastinal large B-cell lymphoma (PMLBCL) is recognized as a distinct disease entity. Treatment outcomes appear better than in other diffuse large B-cell lymphoma (DLBCL) types, partly because of their earlier stage at presentation and the younger age of most patients. If initial treatment fails, however, the results of salvage chemotherapy and myeloablative treatment are poor. The need to avoid relapses after initial therapy has led to controversy over the extent of front-line therapy, particularly whether consolidation radiotherapy to the mediastinum is always required and whether the 18-fluorodeoxyglucose ((18)F-FDG) uptake detected by PET-CT scan can be used to determine its requirements. Functional imaging using PET-CT generally allows distinguishing of residual mediastinal masses containing active lymphoma from those with only sclerotic material remaining. The International Extranodal Lymphoma Study Group (IELSG) conducted the prospective IELSG-26 study, which showed that a five-point visual scale can be used to define metabolic response after immunochemotherapy and that a cut point based on liver uptake discriminates effectively between high or low risk of failure, with 5-year progression-free survival (PFS) of 99% versus 68% and 5-year overall survival (OS) of 100% versus 83%. This study also showed that a baseline quantitative PET parameter, namely the total lesion glycolysis describing the metabolic tumor burden, can be a powerful predictor of PMLBCL outcomes and warrants further validation as a biomarker. The ongoing IELSG-37 randomized study addresses the need for consolidation mediastinal radiotherapy in patients in whom a complete metabolic response (CMR) can be seen on PET scans after standard immunochemotherapy. PMID:27249743

  4. Electronic spectra of 2- and 3-tolunitrile in the gas phase. I. A study of methyl group internal rotation via rovibronically resolved spectroscopy

    NASA Astrophysics Data System (ADS)

    Ruiz-Santoyo, José Arturo; Wilke, Josefin; Wilke, Martin; Yi, John T.; Pratt, David W.; Schmitt, Michael; Álvarez-Valtierra, Leonardo

    2016-01-01

    Rotationally resolved fluorescence excitation spectra of the origin bands in the S1←S0 transition of 2-tolunitrile (2TN) and 3-tolunitrile (3TN) have been recorded in the collision-free environment of a molecular beam. Analyses of these data provide the rotational constants of each molecule and the potential energy curves governing the internal rotation of the attached methyl groups in both electronic states. 2TN exhibits much larger barriers along this coordinate than 3TN. Interestingly, the electronic transition dipole moment in both molecules is markedly influenced by the position of the attached methyl group rather than the position of the cyano group; possible reasons for this intriguing behavior are discussed.

  5. Substantiation of International Nanomaterials Security Group Creation

    NASA Astrophysics Data System (ADS)

    Sosnov, A.; Sadovnikov, S.; Panfilov, S.; Magarshak, Yu.

    Nanotechnology has achieved the status as one of the critical R&D area. Scientists use the unique properties of atomic and molecular assemblages built at the nanometer scale. The ability to manipulate the physical, chemical, and biological properties of molecules and particles affords to design agents with set up properties. But the technology allows creating not only useful agents. Possible accidental or deliberate creation of new nanoparticles (NPs) with dangerous properties is highly probable minor product of progress in the new area. The article briefly describes some pathways in development and implementation of NPs for medicinal and the similar purposes. Some of NPs can effective facilitate and mask transport of various agents in various environments. Possible creation of new dangerous NPs (e.g. conjugates based on combination of extensively use NPs and chemical, biological and radioactive agents) as well as creation of brand new NPs and nanodevices with unique properties needs creation of international multidiscipline community for security evaluation of nanomaterials and technologies. The community will forecast possible dangerous unexpectedness in the field of nanoscale materials and devices and suggests rational pathways for prevention of the threats.

  6. International Technical Working Group Round Robin Tests

    SciTech Connect

    Dudder, Gordon B.; Hanlen, Richard C.; Herbillion, Georges M.

    2003-02-01

    The goal of nuclear forensics is to develop a preferred approach to support illicit trafficking investigations. This approach must be widely understood and accepted as credible. The principal objectives of the Round Robin Tests are to prioritize forensic techniques and methods, evaluate attribution capabilities, and examine the utility of database. The HEU (Highly Enriched Uranium) Round Robin, and previous Plutonium Round Robin, have made tremendous contributions to fulfilling these goals through a collaborative learning experience that resulted from the outstanding efforts of the nine participating internal laboratories. A prioritized list of techniques and methods has been developed based on this exercise. Current work is focused on the extent to which the techniques and methods can be generalized. The HEU Round Robin demonstrated a rather high level of capability to determine the important characteristics of the materials and processes using analytical methods. When this capability is combined with the appropriate knowledge/database, it results in a significant capability to attribute the source of the materials to a specific process or facility. A number of shortfalls were also identified in the current capabilities including procedures for non-nuclear forensics and the lack of a comprehensive network of data/knowledge bases. The results of the Round Robin will be used to develop guidelines or a ''recommended protocol'' to be made available to the interested authorities and countries to use in real cases.

  7. Socialization and selection effects in the association between weight conscious peer groups and thin-ideal internalization: A co-twin control study.

    PubMed

    VanHuysse, Jessica L; Burt, S Alexandra; O'Connor, Shannon M; Thompson, J Kevin; Klump, Kelly L

    2016-06-01

    Affiliation with weight conscious peer groups is theorized to increase thin-ideal internalization through socialization processes. However, selection effects could contribute if genetic and/or environmental predispositions lead to affiliation with weight conscious peers. Co-twin control methodology was used to examine socialization and selection effects in 614 female twins (ages 8-15) from the Michigan State University Twin Registry (MSUTR). Thin-ideal internalization and peer group characteristics were assessed via self-report questionnaires. Results suggested the presence of both socialization and selection effects. In terms of socialization, twins who reported increased exposure to weight conscious peers relative to their co-twins had elevated thin-ideal internalization scores, regardless of zygosity. However, associations between weight conscious peers and thin-ideal internationalization within twin pairs were attenuated, suggesting that genetic and shared environmental selection effects also contribute. Findings significantly extend previous work by confirming the presence of socialization processes and highlighting selection processes to be examined in future longitudinal research. PMID:26859605

  8. Micronucleus frequencies in groups receiving external or internal radiation

    PubMed Central

    Özdal, Ayşegül; Erselcan, Taner; Özdemir, Öztürk; Silov, Güler; Erdoğan, Zeynep; Turhal, Özgül

    2016-01-01

    Objective: In the current study, we aimed to explore whether there is alteration between pre- and post-treatment micronucleus (MN) frequencies induced by internal and external ionizing radiation. Materials and Methods: The study enrolled a total of 67 patients including patients admitted to our hospital for treatment of hyperthyroidism (n = 17), scanning with low-dose I-131 (n = 15), and ablative therapy with high-dose I-131 (n = 15) at Department of Nuclear Medicine as well as patients with different diagnoses receiving external radiotherapy with various doses and durations at Department of Radiation Oncology (n = 20). Thirty-two patients who received radioactive iodine and returned for a follow-up visit at 1 month. Results: Considering both pre- and post-treatment MN frequencies of each group, lowest MN frequencies were detected for patients undergoing screening with low-dose I-131, and highest MN frequencies were found in radiotherapy patients. Comparison of pre- and post-treatment MN frequencies among hyperthyroidism, when pre- and post-treatment MN frequencies compared among hyperthyroidism, I-131 whole body scanning, ablation, and radiotherapy patient groups differences between MN frequencies were significant for each group (P < 0.05). Conclusion: Our study showed that MN analysis might be of value in determining chromosome damage that could potentially occur in patients exposed to internal and external radiation. PMID:27385886

  9. Focus Group Study of Chinese International Students' Knowledge and Beliefs About HPV Vaccination, Before and After Reading an Informational Pamphlet About Gardasil(®).

    PubMed

    Gao, Haijuan; Okoror, Titilayo A; Hyner, Gerald C

    2016-10-01

    An increasing need for Human Papillomavirus (HPV) vaccines in China remains unmet in the mainland and the knowledge and intentions of Chinese youth regarding vaccination is unknown. In the fall of 2013, 44 Chinese international students (CIS) attending a university in the United States Midwest participated in 10 focus group discussions (five female and five male). Result showed that participants have limited awareness and knowledge about HPV infection and vaccination, participants erroneously believed that the causes of cervical cancer are abortion and miscarriage. Participants rely heavily on informal sources such as Chinese-based social media platforms and personal social networks for information on sexually transmitted infections. Sexual cultures and behaviors are perceived differently between CIS born in the 1990s and 1980s. Interestingly, participants' perceived stigma about HPV infection decreased with improving knowledge level during group discussions. In conclusion, HPV vaccine should be further promoted alongside sex education among CIS. PMID:26831655

  10. Study Groups: Conduit for Reform.

    ERIC Educational Resources Information Center

    Makibbin, Shirley S.; Sprague, Marsha M.

    This conference presentation describes study groups as a mechanism for changing teacher behavior. The history of study groups is discussed, beginning with the first American study groups organized by Benjamin Franklin; the Chautauqua Literary and Scientific Circle; the waning of study groups in the early 20th century as college enrollment…

  11. Comparison of the COPD Population Screener and International Primary Care Airway Group questionnaires in a general Japanese population: the Hisayama study

    PubMed Central

    Tsukuya, Go; Samukawa, Takuya; Matsumoto, Koichiro; Fukuyama, Satoru; Kumamoto, Tomohiro; Uchida, Akifumi; Koriyama, Chihaya; Ninomiya, Toshiharu; Inoue, Hiromasa

    2016-01-01

    Background The incidence of chronic obstructive pulmonary disease (COPD) is increasing worldwide. In Japan and other countries, epidemiological studies have found that many patients with COPD are underdiagnosed and untreated, and thus, early detection and treatment of COPD has been emphasized. Screening questionnaires may have utility in the initial detection of COPD. Objective This study aimed to validate and compare the COPD Population Screener (COPD-PS) and the International Primary Care Airway Group (IPAG) questionnaires in a general Japanese population. Patients and methods Eligible subjects 40 years of age and older living in the town of Hisayama were solicited to participate in a health checkup in 2012. All subjects 40–79 years of age without physician-diagnosed asthma or lung resection were recruited, and 2,336 subjects who fully completed both questionnaires and who had valid spirometry measurements were analyzed. Persistent airflow obstruction (AO) was defined by a postbronchodilator forced expiratory volume in 1 second/forced vital capacity <0.70. Receiver operating characteristic curves, net reclassification improvement, and integrated discrimination improvement were used to examine the ability of the COPD-PS and IPAG questionnaires to discriminate between subjects with and without AO. Results The overall area under the receiver operating characteristic curve for the COPD-PS questionnaire was 0.747 (95% confidence interval [CI], 0.707–0.788) and for the IPAG was 0.775 (95% CI, 0.735–0.816), with no significant difference (P=0.09). The net reclassification improvement and integrated discrimination improvement were −0.107 (95% CI, −0.273–0.058; P=0.203) and −0.014 (95% CI, −0.033–0.006; P=0.182), respectively. Conclusion The five-item COPD-PS questionnaire was comparable to the eight-item IPAG for discriminating between subjects with and without AO. The COPD-PS is a simple and useful screening questionnaire for persistent AO. PMID

  12. Focus Groups: An Important Research Technique for Internal Evaluation Units.

    ERIC Educational Resources Information Center

    Duffy, Barbara Poitras

    1993-01-01

    The use of focus groups by the Federal Bureau of Investigation as a tool of internal evaluation is described. Focus groups are used in an environment where credibility is key to achieving meaningful cooperation. Issues for consideration by other evaluators interested in the approach are summarized. (SLD)

  13. Selected Theoretical Studies Group contributions to the 14th International Cosmic Ray conference. [including studies on galactic molecular hydrogen, interstellar reddening, and on the origin of cosmic rays

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The galactic distribution of H2 was studied through gamma radiation and through X-ray, optical, and infrared absorption measurements from SAS-2 and other sources. A comparison of the latitude distribution of gamma-ray intensity with reddening data shows reddening data to give the best estimate of interstellar gas in the solar vicinity. The distribution of galactic cosmic ray nucleons was determined and appears to be identical to the supernova remnant distribution. Interactions between ultrahigh energy cosmic-ray nuclei and intergalactic photon radiation fields were calculated, using the Monte Carlo method.

  14. Metastatic Neuroblastoma Confined to Distant Lymph Nodes (stage 4N) Predicts Outcome in Patients With Stage 4 Disease: A Study From the International Neuroblastoma Risk Group Database

    PubMed Central

    Morgenstern, Daniel A.; London, Wendy B.; Stephens, Derek; Volchenboum, Samuel L.; Hero, Barbara; Di Cataldo, Andrea; Nakagawara, Akira; Shimada, Hiroyuki; Ambros, Peter F.; Matthay, Katherine K.; Cohn, Susan L.; Pearson, Andrew D.J.; Irwin, Meredith S.

    2014-01-01

    Purpose The presence of distant metastases is one of the most powerful predictors of outcome in patients with neuroblastoma. However, the pattern of metastatic spread is not incorporated into current risk stratification systems. Small case series have suggested that patients with neuroblastoma who have metastatic disease limited to distant lymph nodes (4N disease) may have improved outcomes. Patients and Methods We analyzed retrospective data from the International Neuroblastoma Risk Group database for patients diagnosed from 1990 to 2002. 4N patients were compared with the remaining stage 4 patients (non-4N), excluding those with missing metastatic site data. Results In all, 2,250 International Neuroblastoma Staging System stage 4 patients with complete data were identified, of whom 146 (6.5%) had 4N disease. For 4N patients, event-free survival (EFS; 5-year, 77% ± 4%) and overall survival (OS; 5-year, 85% ± 3%) were significantly better than EFS (5-year, 35% ± 1%) and OS (5-year, 42% ± 1%) for non-4N stage 4 patients (P < .001). 4N patients were more likely to be younger (P < .001) and have tumors with favorable characteristics, including absence of MYCN amplification (89% v 69%; P < .001). In a multivariable analysis, 4N disease remained a significant predictor of outcome (hazard ratio for non-4N v 4N: 3.40 for EFS and 3.69 for OS). Within subgroups defined by age at diagnosis and tumor MYCN status, 4N disease was significantly associated with improved outcomes. Conclusion 4N represents a subgroup with better outcome than that of other patients with metastatic disease. These findings suggest that the biology and treatment response of 4N tumors differ from other stage 4 tumors, and less intensive therapy should be considered for this cohort. Future exploration of biologic factors determining the pattern of metastatic spread is warranted. PMID:24663047

  15. Emergency room referral to internal medicine wards or to coronary care units of patients with first acute myocardial infarction. Israel Study Group on First Acute Myocardial Infarction.

    PubMed

    Drory, Y; Shapira, I; Goldbourt, U; Fisman, E Z; Villa, Y; Tenenbaum, A; Pines, A

    2000-01-01

    The objective of the study was to assess factors associated with ward assignment in the emergency room for patients < or = 65 years old with first acute myocardial infarction. We analysed uni- and multivariate predictors for ward assignment (coronary care unit versus internal ward). Eight major centrally located Israeli hospitals provided data during one year. The study population included 1252 patients, of whom 83% were men, 37% were hypertensives, 22% were diabetics, and 14% had previous anginal syndrome. Most patients (83%) were admitted to the coronary care unit. Internal medicine ward assignment was significantly associated with advanced age, history of hypertension or diabetes, a longer time from appearance of symptoms to arrival at the hospital, and myocardial infarction type (non-Q-wave or non-anterior). The likelihood of medical ward referral increased stepwise with the increasing number of a patient's predictive factors: those with > or = 4 factors had a > 30% chance of being assigned to a medical ward compared to a < 10% chance when there were 0-3 risk factors. Exclusion of patients with thrombolysis had no effect on the results. The shortage of cardiac care unit beds apparently leads to emergency room selection acting in detriment of patients with poorest prognoses. Clear guidelines for decision making in the emergency room are needed to resolve this paradoxical situation. PMID:10998758

  16. COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups

    PubMed Central

    2013-01-01

    Background A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders. Methods/Design Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress. Discussion The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing. PMID:24195705

  17. Prognostic significance of pattern and burden of metastatic disease in patients with stage 4 neuroblastoma: A study from the International Neuroblastoma Risk Group database.

    PubMed

    Morgenstern, Daniel A; London, Wendy B; Stephens, Derek; Volchenboum, Samuel L; Simon, Thorsten; Nakagawara, Akira; Shimada, Hiroyuki; Schleiermacher, Gudrun; Matthay, Katherine K; Cohn, Susan L; Pearson, Andrew D J; Irwin, Meredith S

    2016-09-01

    Neuroblastoma is a childhood cancer with remarkably divergent tumour behaviour and the presence of metastatic disease is a powerful predictor of adverse outcome. However, the importance of the involvement of specific metastatic sites or overall metastatic burden in determining outcome has not been fully explored. We analysed data from the International Neuroblastoma Risk Group database for 2250 patients with stage 4 disease treated from 1990 to 2002. Metastatic burden was assessed using a 'metastatic site index' (MSI), a score based on the number of metastatic systems involved. Overall, involvement of bone marrow, bone, lung, central nervous system, or other sites was associated with worse outcome. For patients aged ≥18 months, involvement of liver had the greatest impact on outcome and was associated with tumour MYCN amplification and adrenal primary and lung metastases. Increased MSI was associated with worse outcome and higher baseline ferritin/lactate dehydrogenase. We explored the impact of initial treatment approach on these associations. Limiting the analysis to patients allocated to protocols including stem cell transplant (SCT), there was no longer an association of outcome with metastatic involvement of any individual system or increasing MSI. Thus, treatment escalation with SCT (and the addition of differentiating agents to maintenance therapy) appears to have provided maximal benefit to patients with greatest metastatic disease burden. These findings underscore the importance of examining prognostic factors in the context of specific treatments since the addition of new therapies may change or even negate the predictive impact of a particular variable. PMID:27434878

  18. The International Space Life Sciences Strategic Planning Working Group

    NASA Technical Reports Server (NTRS)

    White, Ronald J.; Rabin, Robert; Lujan, Barbara F.

    1993-01-01

    Throughout the 1980s, ESA and the space agencies of Canada, Germany, France, Japan, and the U.S. have pursued cooperative projects bilaterally and multilaterally to prepare for, and to respond to, opportunities in space life sciences research previously unapproachable in scale and sophistication. To cope effectively with likely future space research opportunities, broad, multilateral, coordinated strategic planning is required. Thus, life scientists from these agencies have allied to form the International Space Life Sciences Strategic Planning Working Group. This Group is formally organized under a charter that specifies the purpose of the Working Group as the development of an international strategic plan for the space life sciences, with periodic revisions as needed to keep the plan current. The plan will be policy-, not operations-oriented. The Working Group also may establish specific implementation teams to coordinate multilateral science policy in specific areas; such teams have been established for space station utilization, and for sharing of flight equipment.

  19. International Business Studies.

    ERIC Educational Resources Information Center

    Hendon, Donald W.

    The new International Business major within the School of Business, begun in fall 1989, is an ongoing, enriched program for highly motivated students of above-average scholastic achievement. Its primary purposes are to (1) prepare students to understand America's trading partners and (2) teach the technical knowledge needed in an international…

  20. Introduction of the UNIX International Performance Management Work Group

    NASA Technical Reports Server (NTRS)

    Newman, Henry

    1993-01-01

    In this paper we presented the planned direction of the UNIX International Performance Management Work Group. This group consists of concerned system developers and users who have organized to synthesize recommendations for standard UNIX performance management subsystem interfaces and architectures. The purpose of these recommendations is to provide a core set of performance management functions and these functions can be used to build tools by hardware system developers, vertical application software developers, and performance application software developers.

  1. International Research and Studies Program

    ERIC Educational Resources Information Center

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    The International Research and Studies Program supports surveys, studies, and instructional materials development to improve and strengthen instruction in modern foreign languages, area studies, and other international fields. The purpose of the program is to improve and strengthen instruction in modern foreign languages, area studies and other…

  2. 76 FR 54800 - International Business Machines (IBM), Software Group Business Unit, Quality Assurance Group, San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-02

    ...), Software Group Business Unit, Optim Data Studio Tools QA, San Jose, California (subject firm). The Department's Notice was published in the Federal Register on February 2, 2011 (76 FR 5832). The subject... Employment and Training Administration International Business Machines (IBM), Software Group Business...

  3. Vagus nerve stimulation for treatment of partial seizures: 2. Safety, side effects, and tolerability. First International Vagus Nerve Stimulation Study Group.

    PubMed

    Ramsay, R E; Uthman, B M; Augustinsson, L E; Upton, A R; Naritoku, D; Willis, J; Treig, T; Barolat, G; Wernicke, J F

    1994-01-01

    Vagus nerve stimulation (VNS) significantly reduces the frequency of partial seizures in refractory epilepsy patients. We examined the serious adverse events, side effects, and tolerability as they relate to the surgical implant procedure and the stimulating device. We also reviewed potential drug interactions, device output complications, and impact of the therapy on overall health status. We analyzed the first 67 patients to exist the acute phase of the EO3 VNS trial comparing high (therapeutic) VNS to low (less or noneffective) VNS. Data were collected from case report forms used at each of the four visits during the 12-week baseline and at each of the four visits during the 14-week randomized phase of the trial. No significant complications were reported as a result of the implant procedure. Serious adverse events included 1 patient who experienced direct current to the vagus nerve owing to generator malfunction resulting in left vocal cord paralysis and withdrawal of the patient from the study. No clinically significant effects on vital signs, cardiac function, or gastric function were detected. Side effects associated with VNS in the high group were hoarseness (35.5%), coughing (13.9%), and throat pain (12.9%). In the low group, only hoarseness (13.9%) and throat pain (13.9%) were associated with VNS. These effects generally wrre not considered clinically significant and occurred primarily during the stimulation pulses. No patients discontinued VNS therapy during the acute phase because of side effects associated with normal stimulation. Except for the one instance of a short circuit in the system resulting in a direct current, stimulating system complications were minor, limited to programming, unscheduled stimulation, and high lead impedance. Patients, investigators, and patient companions rated patients receiving high stimulation as more "improved" than those receiving low stimulation in regards to overall health status. Antiepileptic drug (AED) plasma

  4. International Technical Working Group Cooperation to Counter Illicit Nuclear Trafficking

    SciTech Connect

    Smith, D K; Niemeyer, S

    2004-09-18

    The Nuclear Smuggling International Technical Working Group (ITWG) is an international body of nuclear forensic experts that cooperate to deter the illicit trafficking of nuclear materials. The objective of the ITWG is to provide a common approach and effective technical solutions to governments who request assistance in nuclear forensics. The ITWG was chartered in 1996 and since that time more than 28 nations and organizations have participated in 9 international meetings and 2 analytical round-robin trials. Soon after its founding the ITWG adopted a general framework to guide nuclear forensics investigations that includes recommendations for nuclear crime scene security and analysis, the best application of radioanalytical methods, the conduct of traditional forensic analysis of contaminated materials, and effective data analysis to interpret the history of seized nuclear materials. This approach has been adopted by many nations as they respond to incidents of illicit nuclear trafficking.

  5. Paraneoplastic itch: an expert position statement from the Special Interest Group (SIG) of the International Forum on the Study of Itch (IFSI).

    PubMed

    Weisshaar, Elke; Weiss, Melanie; Mettang, Thomas; Yosipovitch, Gil; Zylicz, Zbigniew

    2015-03-01

    In clinical practice, the term "paraneoplastic itch" is used to describe itch in patients with cancer. Patients with hematological or solid tumor malignancies can be affected. In general, paraneoplastic itch is considered a rare disorder. However, paraneoplastic itch in hematological malignancies such as polycythemia vera and lymphoma are relatively frequent while other forms of paraneoplastic itch are in fact extremely rare. The true frequency of this symptom is unclear, epidemiological data in this field are limited. Itch in malignant disease may additionally impair patients' quality of life. A population-based cohort study showed that chronic itch without concomitant skin changes is a risk factor for having undiagnosed hematologic and bile duct malignancies. Paraneoplastic itch is rather resistant to treatment. In 2012, an interdisciplinary interest group of physicians and researchers was founded, aiming to generate a clear definition of paraneoplastic itch. In this paper we briefly review the current knowledge and aim to define what can be summarized under the term "paraneoplastic itch". PMID:25179683

  6. Internal character dictates transition dynamics between isolation and cohesive grouping

    NASA Astrophysics Data System (ADS)

    Manrique, Pedro D.; Hui, Pak Ming; Johnson, Neil F.

    2015-12-01

    We show that accounting for internal character among interacting heterogeneous entities generates rich transition behavior between isolation and cohesive dynamical grouping. Our analytical and numerical calculations reveal different critical points arising for different character-dependent grouping mechanisms. These critical points move in opposite directions as the population's diversity decreases. Our analytical theory may help explain why a particular class of universality is so common in the real world, despite the fundamental differences in the underlying entities. It also correctly predicts the nonmonotonic temporal variation in connectivity observed recently in one such system.

  7. Valaciclovir versus aciclovir in patient initiated treatment of recurrent genital herpes: a randomised, double blind clinical trial. International Valaciclovir HSV Study Group.

    PubMed Central

    Bodsworth, N J; Crooks, R J; Borelli, S; Vejlsgaard, G; Paavonen, J; Worm, A M; Uexkull, N; Esmann, J; Strand, A; Ingamells, A J; Gibb, A

    1997-01-01

    OBJECTIVE: To compare the efficacy and safety of twice daily valaciclovir with five times daily aciclovir in the treatment of an episode of recurrent genital herpes simplex virus (HSV) infection in immunocompetent individuals. METHODS: 739 patients with a history of recurrent genital HSV infection received either oral valaciclovir (500 mg twice daily) or aciclovir (200 mg five times daily) for 5-days for treatment of their next recurrent episode in a controlled, randomised, double blind trial. Patients self initiated therapy at the first signs and/or symptoms of the HSV recurrence, then were assessed in clinic on five occasions over 7 days, and twice weekly thereafter until lesions had healed. Safety was evaluated through adverse experience reports and haematology and biochemistry monitoring. RESULTS: No significant differences were detected between valaciclovir and aciclovir for the primary endpoint, the duration of all signs and symptoms which included lesion healing and pain/discomfort. The hazard ratio [95% confidence interval] for valaciclovir v aciclovir was 0.93 [0.79, 1.08]. Lesion healing time was similar in each treatment group (hazard ratio valaciclovir v aciclovir 0.96 [0.80, 1.14]). The odds ratio of valaciclovir v aciclovir in preventing the development of vesicular/ulcerative lesions was 1.08 [0.82, 1.42]. Percentages of patients in whom all HSV cultures were negative were similar in the valaciclovir and aciclovir groups at 59% and 54% respectively; for patients having equal to or more than one positive culture result after treatment initiation, cessation of virus shedding was similarly rapid for the two treatments (hazard ratio 0.98 [0.75, 1.27]). The safety profiles of valaciclovir and aciclovir were comparable with adverse experiences being infrequent and generally mild. CONCLUSION: This study has demonstrated that valaciclovir 500 mg twice daily is equivalent in efficacy to aciclovir 200 mg five times daily as episodic treatment of recurrent

  8. One center in Brussels has consistently had the lowest HbA1c values in the 4 studies (1994-2009) by the Hvidoere International Study Group on Childhood Diabetes: What are the "recipes"?

    PubMed Central

    Dorchy, Harry

    2015-01-01

    The principal aims of therapeutic management of the child, adolescent and adult with type 1 diabetes are to allow good quality of life and to avoid long-term complications (retinopathy, neuropathy, nephropathy, cardiovascular disease, etc.) by maintaining blood glucose concentrations close to normal level. Glycated hemoglobin levels (HbA1c) provide a good criterion of overall glycemic control. The Hvidoere Study Group (HSG) on Childhood Diabetes, founded in 1994, is an international group representing about twenty highly experienced pediatric centers from Europe, North America, Japan and Australia. Four international comparisons of metabolic control (1995, 1998, 2005, 2009) have been performed. The one center that has consistently had the lowest HbA1c values (approximate 7.3% or 56.3 mmol/mol) is my center in Brussels. This is more often obtained with a twice-daily free-mixed regimen with additional supplemental fast insulins ad hoc. The so-called “Dorchy’s recipes” are summarized. The conclusion is that the number of daily insulin injections, 2 or ≥ 4, or the use of pumps, by itself does not necessarily give better results. Intensified therapy should not depend upon the number of insulin doses per day, by syringe, pen or pump but rather should be redefined as to intent-to-treat ascertainment (i.e., goals). When there are no mutually agreed upon goals for BG and/or HbA1c, when there is insufficient education and psychosocial support by the medical team or at home, there is likely to be poor outcomes, as shown by the HSG. One of our recipes is not to systematically replace rapid-acting human insulins by fast-acting analogues. Because the multicenter studies of the HSG, performed in developed countries without financial restriction, show that treatment of childhood diabetes is inadequate in general and that levels of HbA1c are very different, diabetes treatment teams should individually explore the reasons for failure, without any prejudice or bias. Any

  9. One center in Brussels has consistently had the lowest HbA1c values in the 4 studies (1994-2009) by the Hvidoere International Study Group on Childhood Diabetes: What are the "recipes"?

    PubMed

    Dorchy, Harry

    2015-02-15

    The principal aims of therapeutic management of the child, adolescent and adult with type 1 diabetes are to allow good quality of life and to avoid long-term complications (retinopathy, neuropathy, nephropathy, cardiovascular disease, etc.) by maintaining blood glucose concentrations close to normal level. Glycated hemoglobin levels (HbA1c) provide a good criterion of overall glycemic control. The Hvidoere Study Group (HSG) on Childhood Diabetes, founded in 1994, is an international group representing about twenty highly experienced pediatric centers from Europe, North America, Japan and Australia. Four international comparisons of metabolic control (1995, 1998, 2005, 2009) have been performed. The one center that has consistently had the lowest HbA1c values (approximate 7.3% or 56.3 mmol/mol) is my center in Brussels. This is more often obtained with a twice-daily free-mixed regimen with additional supplemental fast insulins ad hoc. The so-called "Dorchy's recipes" are summarized. The conclusion is that the number of daily insulin injections, 2 or ≥ 4, or the use of pumps, by itself does not necessarily give better results. Intensified therapy should not depend upon the number of insulin doses per day, by syringe, pen or pump but rather should be redefined as to intent-to-treat ascertainment (i.e., goals). When there are no mutually agreed upon goals for BG and/or HbA1c, when there is insufficient education and psychosocial support by the medical team or at home, there is likely to be poor outcomes, as shown by the HSG. One of our recipes is not to systematically replace rapid-acting human insulins by fast-acting analogues. Because the multicenter studies of the HSG, performed in developed countries without financial restriction, show that treatment of childhood diabetes is inadequate in general and that levels of HbA1c are very different, diabetes treatment teams should individually explore the reasons for failure, without any prejudice or bias. Any dogmatism

  10. Proceedings of the Twentieth International Microgravity Measurements Group Meeting

    NASA Technical Reports Server (NTRS)

    DeLombard, Richard (Compiler)

    2001-01-01

    The International Microgravity Measurements Group annual meetings provide a forum for an exchange of information and ideas about various aspects of microgravity acceleration research in international microgravity research programs. These meetings are sponsored by the PI Microgravity Services (PIMS) project at the NASA Glenn Research Center. The twentieth MGMG meeting was held 7-9 August 2001 at the Hilton Garden Inn Hotel in Cleveland, Ohio. The 35 attendees represented NASA, other space agencies, universities, and commercial companies; eight of the attendees were international representatives from Canada, Germany, Italy, Japan, and Russia. Seventeen presentations were made on a variety of microgravity environment topics including the International Space Station (ISS), acceleration measurement and analysis results, science effects from microgravity accelerations, vibration isolation, free flyer satellites, ground testing, and microgravity outreach. Two working sessions were included in which a demonstration of ISS acceleration data processing and analyses were performed with audience participation. Contained within the minutes is the conference agenda which indicates each speaker, the title of their presentation, and the actual time of their presentation. The minutes also include the charts for each presentation which indicate the author's name(s) and affiliation. In some cases, a separate written report was submitted and has been included here.

  11. Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group

    PubMed Central

    Palumbo, Antonio; Avet-Loiseau, Hervé; Oliva, Stefania; Lokhorst, Henk M.; Goldschmidt, Hartmut; Rosinol, Laura; Richardson, Paul; Caltagirone, Simona; Lahuerta, Juan José; Facon, Thierry; Bringhen, Sara; Gay, Francesca; Attal, Michel; Passera, Roberto; Spencer, Andrew; Offidani, Massimo; Kumar, Shaji; Musto, Pellegrino; Lonial, Sagar; Petrucci, Maria T.; Orlowski, Robert Z.; Zamagni, Elena; Morgan, Gareth; Dimopoulos, Meletios A.; Durie, Brian G.M.; Anderson, Kenneth C.; Sonneveld, Pieter; San Miguel, Jésus; Cavo, Michele; Rajkumar, S. Vincent; Moreau, Philippe

    2015-01-01

    Purpose The clinical outcome of multiple myeloma (MM) is heterogeneous. A simple and reliable tool is needed to stratify patients with MM. We combined the International Staging System (ISS) with chromosomal abnormalities (CA) detected by interphase fluorescent in situ hybridization after CD138 plasma cell purification and serum lactate dehydrogenase (LDH) to evaluate their prognostic value in newly diagnosed MM (NDMM). Patients and Methods Clinical and laboratory data from 4,445 patients with NDMM enrolled onto 11 international trials were pooled together. The K-adaptive partitioning algorithm was used to define the most appropriate subgroups with homogeneous survival. Results ISS, CA, and LDH data were simultaneously available in 3,060 of 4,445 patients. We defined the following three groups: revised ISS (R-ISS) I (n = 871), including ISS stage I (serum β2-microglobulin level < 3.5 mg/L and serum albumin level ≥ 3.5 g/dL), no high-risk CA [del(17p) and/or t(4;14) and/or t(14;16)], and normal LDH level (less than the upper limit of normal range); R-ISS III (n = 295), including ISS stage III (serum β2-microglobulin level > 5.5 mg/L) and high-risk CA or high LDH level; and R-ISS II (n = 1,894), including all the other possible combinations. At a median follow-up of 46 months, the 5-year OS rate was 82% in the R-ISS I, 62% in the R-ISS II, and 40% in the R-ISS III groups; the 5-year PFS rates were 55%, 36%, and 24%, respectively. Conclusion The R-ISS is a simple and powerful prognostic staging system, and we recommend its use in future clinical studies to stratify patients with NDMM effectively with respect to the relative risk to their survival. PMID:26240224

  12. Remark on Groups and Internal Structure in Continuum Mechanics

    NASA Astrophysics Data System (ADS)

    Günther, H.

    Any mechanical motion within a solid is subjected to the group of external motion (Galilean group or if necessary for relativistic mechanics the Lorentz group) and to the internal quasi Lorentz group lq being independent of the external one. Since the effect of the external group always may be simulated by a system of external forces, any internal property is subjected to lq (e.g. quasi masses of defects). The principle of minimal coupling explicitely used in 1969 by KLUGE for mechanical defects within a solid, being extended in 1983 by KADIC and EDELEN by the help of Yang-Mills-theory for introducing phenomenological terms of inertia for mechanical defects, is leading to the relation with the field theoretical masses for defects as in electrodynamics.Translated AbstractBemerkung über Gruppen und innere Struktur der KontiuumsmechanikDie mechanischen Bewegungen eines Festkörpers unterliegen der Gruppe der äußeren Bewegung (der Galileigruppe bzw. für eine relativistische Mechanik der Lorentzgruppe) sowie der davon unabhängigen inneren quasi Lorentzgruppe lq. Da sich der Einfluß der äußeren Gruppe immer durch ein System äußerer Kräfte simulieren läßt, unterliegen die inneren Eigenschaften der Gruppe lq (z. B. Quasimassen der Defekte). Das durch KLUGE 1969 auf die Strukturdefekte des Festkörpers übertragene Prinzip der minimalen Kopplung, was durch KADIĆ und EDELEN 1983 im Rahmen des Yang-Mills-Formalismus durch Einführung phenomenologischer Trägheitsterme für die Defekte erweitert wurde, führt auf die Frage nach dem Zusammenhang mit den feldtheoretischen Massen der Defekte in Analogie zur Elektrodynamik.

  13. Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM).

    PubMed

    Della Porta, M G; Tuechler, H; Malcovati, L; Schanz, J; Sanz, G; Garcia-Manero, G; Solé, F; Bennett, J M; Bowen, D; Fenaux, P; Dreyfus, F; Kantarjian, H; Kuendgen, A; Levis, A; Cermak, J; Fonatsch, C; Le Beau, M M; Slovak, M L; Krieger, O; Luebbert, M; Maciejewski, J; Magalhaes, S M M; Miyazaki, Y; Pfeilstöcker, M; Sekeres, M A; Sperr, W R; Stauder, R; Tauro, S; Valent, P; Vallespi, T; van de Loosdrecht, A A; Germing, U; Haase, D; Greenberg, P L; Cazzola, M

    2015-07-01

    A risk-adapted treatment strategy is mandatory for myelodysplastic syndromes (MDS). We refined the World Health Organization (WHO)-classification-based Prognostic Scoring System (WPSS) by determining the impact of the newer clinical and cytogenetic features, and we compared its prognostic power to that of the revised International Prognostic Scoring System (IPSS-R). A population of 5326 untreated MDS was considered. We analyzed single WPSS parameters and confirmed that the WHO classification and severe anemia provide important prognostic information in MDS. A strong correlation was found between the WPSS including the new cytogenetic risk stratification and WPSS adopting original criteria. We then compared WPSS with the IPSS-R prognostic system. A highly significant correlation was found between the WPSS and IPSS-R risk classifications. Discrepancies did occur among lower-risk patients in whom the number of dysplastic hematopoietic lineages as assessed by morphology did not reflect the severity of peripheral blood cytopenias and/or increased marrow blast count. Moreover, severe anemia has higher prognostic weight in the WPSS versus IPSS-R model. Overall, both systems well represent the prognostic risk of MDS patients defined by WHO morphologic criteria. This study provides relevant in formation for the implementation of risk-adapted strategies in MDS. PMID:25721895

  14. Loneliness and International Students: An Australian Study

    ERIC Educational Resources Information Center

    Sawir, Erlenawati; Marginson, Simon; Deumert, Ana; Nyland, Chris; Ramia, Gaby

    2008-01-01

    In a study of international student security, consisting of 200 intensive interviews with students, resident onshore in Australia, it was found that two thirds of the group had experienced problems of loneliness and/or isolation, especially in the early months. According to Weiss, students experience both "personal loneliness" because of the loss…

  15. International strategic minerals inventory summary report: platinum-group metals

    USGS Publications Warehouse

    Sutphin, David M.; Page, Norman J

    1986-01-01

    Major world resources of platinum-group metals are described in this summary report of information in the International Strategic Minerals Inventory {ISMI}. ISMI is a cooperative data-collection effort of earth-science and mineral-resource agencies in Australia, Canada, the Federal Republic of Germany, the Republic of South Africa, and the United States of America. This report, designed to be of benefit to policy analysts, contains two parts. Part I presents an overview of the resources and potential supply of platinum-group metals on the basis of inventory information. Part II contains tables of some of the geologic information and mineral-resource and production data that were collected by ISMI participants.

  16. International Piping Integrity Research Group (IPIRG) Program. Final report

    SciTech Connect

    Wilkowski, G.; Schmidt, R.; Scott, P.

    1997-06-01

    This is the final report of the International Piping Integrity Research Group (IPIRG) Program. The IPIRG Program was an international group program managed by the U.S. Nuclear Regulatory Commission and funded by a consortium of organizations from nine nations: Canada, France, Italy, Japan, Sweden, Switzerland, Taiwan, the United Kingdom, and the United States. The program objective was to develop data needed to verify engineering methods for assessing the integrity of circumferentially-cracked nuclear power plant piping. The primary focus was an experimental task that investigated the behavior of circumferentially flawed piping systems subjected to high-rate loadings typical of seismic events. To accomplish these objectives a pipe system fabricated as an expansion loop with over 30 meters of 16-inch diameter pipe and five long radius elbows was constructed. Five dynamic, cyclic, flawed piping experiments were conducted using this facility. This report: (1) provides background information on leak-before-break and flaw evaluation procedures for piping, (2) summarizes technical results of the program, (3) gives a relatively detailed assessment of the results from the pipe fracture experiments and complementary analyses, and (4) summarizes advances in the state-of-the-art of pipe fracture technology resulting from the IPIRG program.

  17. Dummy Run of Quality Assurance Program in a Phase 3 Randomized Trial Investigating the Role of Internal Mammary Lymph Node Irradiation in Breast Cancer Patients: Korean Radiation Oncology Group 08-06 Study

    SciTech Connect

    Chung, Yoonsun; Kim, Jun Won; Shin, Kyung Hwan; Kim, Su Ssan; Ahn, Sung-Ja; Park, Won; Lee, Hyung-Sik; Kim, Dong Won; Lee, Kyu Chan; Suh, Hyun Suk; Kim, Jin Hee; Shin, Hyun Soo; Kim, Yong Bae; Suh, Chang-Ok

    2015-02-01

    Purpose: The Korean Radiation Oncology Group (KROG) 08-06 study protocol allowed radiation therapy (RT) technique to include or exclude breast cancer patients from receiving radiation therapy to the internal mammary lymph node (IMN). The purpose of this study was to assess dosimetric differences between the 2 groups and potential influence on clinical outcome by a dummy run procedure. Methods and Materials: All participating institutions were asked to produce RT plans without irradiation (Arm 1) and with irradiation to the IMN (Arm 2) for 1 breast-conservation treatment case (breast-conserving surgery [BCS]) and 1 mastectomy case (modified radical mastectomy [MRM]) whose computed tomography images were provided. We assessed interinstitutional variations in IMN delineation and evaluated the dose-volume histograms of the IMN and normal organs. A reference IMN was delineated by an expert panel group based on the study guidelines. Also, we analyzed the potential influence of actual dose variation observed in this study on patient survival. Results: Although physicians intended to exclude the IMN within the RT field, the data showed almost 59.0% of the prescribed dose was delivered to the IMN in Arm 1. However, the mean doses covering the IMN in Arm 1 and Arm 2 were significantly different for both cases (P<.001). Due to the probability of overdose in Arm 1, the estimated gain in 7-year disease-free survival rate would be reduced from 10% to 7.9% for BCS cases and 7.1% for MRM cases. The radiation doses to the ipsilateral lung, heart, and coronary artery were lower in Arm 1 than in Arm 2. Conclusions: Although this dummy run study indicated that a substantial dose was delivered to the IMN, even in the nonirradiation group, the dose differences between the 2 groups were statistically significant. However, this dosimetric profile should be studied further with actual patient samples and be taken into consideration when analyzing clinical outcomes according to IMN

  18. International Planetary Data Alliance (IPDA) Technical Experts Group

    NASA Astrophysics Data System (ADS)

    Osuna, P.; Salgado, J.

    2012-09-01

    created in 2005 as an effort to make the different agencies dealing with planetary data come to homogeneous and interoperable approaches for the handling of their data. The IPDA's main emphasis is to ease discovery, access and use of planetary data by world-wide scientists regardless of which agency is collecting and distributing the data. Ensuring proper capture, accessibility and availability of the data is the task of the individual space agencies. The IPDA is focusing on developing an international standard which allows the following capabilities: query, access and usage of data across international planetary data archive systems. While, trends in other areas of space science are concentrating on the sharing of science data from diverse standards and collection methods, the IPDA shall concentrate on promoting standards which drive common methods for collecting and describing planetary science data across the international community. Such an approach will better support the long term goal of easing data sharing across system and agency boundaries. The IPDA web pages can be found at the following link: http://planetarydata.org/ The IPDA Technical Experts Group (IPDA TEG) was created to ensure correct integration of the different standards created within the alliance. The Technical Experts Group of the IPDA provides oversight on system and software standards and architectures under development by the IPDA. It is responsible for coordination of technical projects and ensuring that the projects are compatible with the IPDA system architecture and requirements. The IPDA TEG is empowered by the Steering Committee to design and develop technical standards that meet the IPDA requirements and fit within the IPDA system architecture. The TEG is responsible to review and approve standards when they are ready for submission to the Steering Committee. This paper will summarise the activities of the IPDA TEG during its conception with particular emphasis in the recent

  19. International Instructional Systems: Social Studies

    ERIC Educational Resources Information Center

    Brant, Jacek; Chapman, Arthur; Isaacs, Tina

    2016-01-01

    This paper reports on research conducted as part of the International Instructional System Study that explored five subject areas across nine jurisdictions in six high-performing countries. The Study's overall aim was to understand what, if anything, there is in common in the curricula and assessment arrangements among the high-performing…

  20. Pediatric acute myeloid leukemia with t(8;16)(p11;p13), a distinct clinical and biological entity: a collaborative study by the International-Berlin-Frankfurt-Münster AML-study group

    PubMed Central

    Coenen, Eva A.; Zwaan, C. Michel; Reinhardt, Dirk; Harrison, Christine J.; Haas, Oskar A.; de Haas, Valerie; Mihál, Vladimir; De Moerloose, Barbara; Jeison, Marta; Rubnitz, Jeffrey E.; Tomizawa, Daisuke; Johnston, Donna; Alonzo, Todd A.; Hasle, Henrik; Auvrignon, Anne; Dworzak, Michael; Pession, Andrea; van der Velden, Vincent H. J.; Swansbury, John; Wong, Kit-fai; Terui, Kiminori; Savasan, Sureyya; Winstanley, Mark; Vaitkeviciene, Goda; Zimmermann, Martin; Pieters, Rob; van den Heuvel-Eibrink, Marry M.

    2013-01-01

    In pediatric acute myeloid leukemia (AML), cytogenetic abnormalities are strong indicators of prognosis. Some recurrent cytogenetic abnormalities, such as t(8;16)(p11;p13), are so rare that collaborative studies are required to define their prognostic impact. We collected the clinical characteristics, morphology, and immunophenotypes of 62 pediatric AML patients with t(8;16)(p11;p13) from 18 countries participating in the International Berlin-Frankfurt-Münster (I-BFM) AML study group. We used the AML-BFM cohort diagnosed from 1995-2005 (n = 543) as a reference cohort. Median age of the pediatric t(8;16)(p11;p13) AML patients was significantly lower (1.2 years). The majority (97%) had M4-M5 French-American-British type, significantly different from the reference cohort. Erythrophagocytosis (70%), leukemia cutis (58%), and disseminated intravascular coagulation (39%) occurred frequently. Strikingly, spontaneous remissions occurred in 7 neonates with t(8;16)(p11;p13), of whom 3 remain in continuous remission. The 5-year overall survival of patients diagnosed after 1993 was 59%, similar to the reference cohort (P = .14). Gene expression profiles of t(8;16)(p11;p13) pediatric AML cases clustered close to, but distinct from, MLL-rearranged AML. Highly expressed genes included HOXA11, HOXA10, RET, PERP, and GGA2. In conclusion, pediatric t(8;16)(p11;p13) AML is a rare entity defined by a unique gene expression signature and distinct clinical features in whom spontaneous remissions occur in a subset of neonatal cases. PMID:23974201

  1. On Sufism, Sufi Group Study and Group Leadership.

    ERIC Educational Resources Information Center

    Einhorn, Jay

    1979-01-01

    Sufism is an ancient tradition of experiential human development. Sufi human development specialists utilize the group setting as a major study format. Comparison with group counseling might broaden perspectives on the possibilities and pitfalls of group process, and pinpoint several important issues relevant to group leadership. (Author)

  2. Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. Intersalt Cooperative Research Group.

    PubMed Central

    1988-01-01

    The relations between 24 hour urinary electrolyte excretion and blood pressure were studied in 10,079 men and women aged 20-59 sampled from 52 centres around the world based on a highly standardised protocol with central training of observers, a central laboratory, and extensive quality control. Relations between electrolyte excretion and blood pressure were studied in individual subjects within each centre and the results of these regression analyses pooled for all 52 centres. Relations between population median electrolyte values and population blood pressure values were also analysed across the 52 centres. Sodium excretion ranged from 0.2 mmol/24 h (Yanomamo Indians, Brazil) to 242 mmol/24 h (north China). In individual subjects (within centres) it was significantly related to blood pressure. Four centres found very low sodium excretion, low blood pressure, and little or no upward slope of blood pressure with age. Across the other 48 centres sodium was significantly related to the slope of blood pressure with age but not to median blood pressure or prevalence of high blood pressure. Potassium excretion was negatively correlated with blood pressure in individual subjects after adjustment for confounding variables. Across centres there was no consistent association. The relation of sodium to potassium ratio to blood pressure followed a pattern similar to that of sodium. Body mass index and heavy alcohol intake had strong, significant independent relations with blood pressure in individual subjects. PMID:3416162

  3. Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group study.

    PubMed

    Kumar, S K; Lee, J H; Lahuerta, J J; Morgan, G; Richardson, P G; Crowley, J; Haessler, J; Feather, J; Hoering, A; Moreau, P; LeLeu, X; Hulin, C; Klein, S K; Sonneveld, P; Siegel, D; Bladé, J; Goldschmidt, H; Jagannath, S; Miguel, J S; Orlowski, R; Palumbo, A; Sezer, O; Rajkumar, S V; Durie, B G M

    2012-01-01

    Promising new drugs are being evaluated for treatment of multiple myeloma (MM), but their impact should be measured against the expected outcome in patients failing current therapies. However, the natural history of relapsed disease in the current era remains unclear. We studied 286 patients with relapsed MM, who were refractory to bortezomib and were relapsed following, refractory to or ineligible to receive, an IMiD (immunomodulatory drug), had measurable disease, and ECOG PS of 0, 1 or 2. The date patients satisfied the entry criteria was defined as time zero (T(0)). The median age at diagnosis was 58 years, and time from diagnosis to T(0) was 3.3 years. Following T(0), 213 (74%) patients had a treatment recorded with one or more regimens (median=1; range 0-8). The first regimen contained bortezomib in 55 (26%) patients and an IMiD in 70 (33%). A minor response or better was seen to at least one therapy after T(0) in 94 patients (44%) including ≥ partial response in 69 (32%). The median overall survival and event-free survival from T(0) were 9 and 5 months, respectively. This study confirms the poor outcome, once patients become refractory to current treatments. The results provide context for interpreting ongoing trials of new drugs. PMID:21799510

  4. Risk of Progression and Survival in Multiple Myeloma Relapsing After Therapy with IMiDs and Bortezomib: A Multicenter International Myeloma Working Group Study

    PubMed Central

    Kumar, Shaji; Lee, Jae Hoon; Lahuerta, Juan J.; Morgan, Gareth; Richardson, Paul G.; Crowley, John; Haessler, Jeff; Feather, John; Hoering, Antje; Moreau, Philippe; LeLeu, Xavier; Hullin, Cyrille; Klein, Saskia K.; Sonneveld, Pieter; Siegel, David; Bladé, Joan; Goldschmidt, Hartmut; Jagannath, Sundar; San Miguel, Jesus; Orlowski, Robert; Palumbo, Antonio; Sezer, Orhan; Durie, Brian G.M.

    2014-01-01

    Promising new drugs are being evaluated for treatment of multiple myeloma (MM), but their impact should be measured against the expected outcome in patients failing current therapies. However, the natural history of relapsed disease in the current era remains unclear. We studied 286 patients with relapsed MM, who were refractory to bortezomib and were relapsed, refractory, or ineligible, to an IMiD (Immunomodulatory Drug), with measurable disease and ECOG PS of 0, 1 or 2. The date patients satisfied the entry criteria was defined as time zero (T0). The median age at diagnosis was 58 years and time from diagnosis to T0 was 3.3 years. Following T0, 213 (74%) patients had a treatment recorded with one or more regimens (median=1; range 0-8). The first regimen contained bortezomib in 55 (26%) patients and an IMiD in 70 (33%). A minor response or better was seen to at least one therapy after T0 in 94 patients (51%) including >=partial response in 69 (38%). The median overall survival and event free survival from T0 were 9 and 5 months respectively. This study confirms the poor outcome once patients become refractory to current treatments. The results provide context for interpreting ongoing trials of new drugs. PMID:21799510

  5. International Working Group on MDS cytogenetics: October 2007 meeting report.

    PubMed

    Slovak, Marilyn L; Dewald, Gordon W

    2008-09-01

    The inaugural meeting of the International Working Group on MDS cytogenetics convened 22-23 October 2007 in Chicago, IL. Under the sponsorship of the Myelodysplastic Syndromes Foundation, the group was organized to address the substantial need for worldwide standardized cytogenetic testing for MDS in clinical practice and research. Eighteen cytogeneticists from 10 countries attended the first working group meeting. Representatives from France and Austria were unable to attend the Chicago meeting. Marilyn L. Slovak, PhD (City of Hope, USA) served as Working Group Chair and Gordon Dewald, PhD (Mayo Clinic, USA), served as Working Group Advisor and Co-Chair. Other members in attendance included: Mette Andersen, Rigshospitalet, Denmark; Lynda Campbell, St. Vincent's Hospital Melbourne, Australia; Athena Cherry, Stanford University, USA; Kathy Chun, North York General Hospital, Canada; Mike Griffiths, West Midlands Regional Genetics Lab, UK; Detlef Haase, Georg-August-Universität, Germany; Claudia Haferlach, MLL Münchner Leukämielabor GmbH, Germany; Anne Hagemeijer, University of Leuven, Belgium; Barbara Hildebrandt, Institut für Humangenetik & Anthropologie Dupsilonsseldorf, Germany; Douglas Horsman, BC Cancer Agency, Canada; M. Anwar Iqbal, University of Rochester, USA; Suresh Jhanwar, Memorial Sloan-Kettering Cancer Center, USA; Bertil Johansson, University Hospital, Sweden; Michelle LeBeau, University of Chicago, USA; Kazuma Ohyashiki, Tokyo Medical University, Japan; Francesc Solé, Hospital del Mar, Spain. The focus of the working group was to establish the natural history and clinical significance of cytogenetic anomalies associated with the myelodysplastic syndromes (MDS), and to incorporate cytogenetic testing into the development of new treatments to cure MDS. Three specific goals were discussed in an effort to rapidly improve the care of patients with MDS. The first goal was how to educate physicians on the appropriate use of cost effective cytogenetic

  6. The International Astronomical Union Working Group on Publishing}

    NASA Astrophysics Data System (ADS)

    Storey, Michelle C.

    This talk introduced the IAU Working Group on Publishing (WG Publishing) and sought feedback from the LISA IV participants on which issues should be priority issues for the Working Group. Feedback was also sought on a draft of a new model for publishing the IAU Symposia and Colloquia. The IAU's mission is to promote and safeguard the science of astronomy through international cooperation. The IAU currently has over 8,700 individual members and 66 adhering country members. The purpose of the WG Publishing is to look at how research results are being, and ought to be, published. Issues on which feedback was sought at the LISA IV meeting include: 1. After the termination of Astronomy and Astrophysics Abstracts, can the IAU support some abstracting service with an international scope, in order to encourage the wide awareness of astronomical research from all over the world? 2. The WG Publishing has been working to promote the adherence to consistent standards of nomenclature and data inclusion in refereed papers 3. A new proposed model for publishing IAU-sponsored Symposia and Colloquia, based on a journal model and not individual hardcopy conference books 4. The concentration of astronomical literature into a few core journals 5. Peer review and the possibility of astronomical journals exploring innovative peer review options such as open reviewing 6. Archiving. As the presentation was principally a request for feedback and ideas it is not suitable for submission as a formal manuscript. Participants and others who wish to make input to the WG Publishing are encouraged to contact the Chair, Michelle Storey on michelle.storey@csiro.au.

  7. Three-dimensional Reconstruction of Peripheral Nerve Internal Fascicular Groups

    PubMed Central

    Zhong, Yingchun; Wang, Liping; Dong, Jianghui; Zhang, Yi; Luo, Peng; Qi, Jian; Liu, Xiaolin; Xian, Cory J.

    2015-01-01

    Peripheral nerves are important pathways for receiving afferent sensory impulses and sending out efferent motor instructions, as carried out by sensory nerve fibers and motor nerve fibers. It has remained a great challenge to functionally reconnect nerve internal fiber bundles (or fascicles) in nerve repair. One possible solution may be to establish a 3D nerve fascicle visualization system. This study described the key technology of 3D peripheral nerve fascicle reconstruction. Firstly, fixed nerve segments were embedded with position lines, cryostat-sectioned continuously, stained and imaged histologically. Position line cross-sections were identified using a trained support vector machine method, and the coordinates of their central pixels were obtained. Then, nerve section images were registered using the bilinear method, and edges of fascicles were extracted using an improved gradient vector flow snake method. Subsequently, fascicle types were identified automatically using the multi-directional gradient and second-order gradient method. Finally, a 3D virtual model of internal fascicles was obtained after section images were processed. This technique was successfully applied for 3D reconstruction for the median nerve of the hand-wrist and cubital fossa regions and the gastrocnemius nerve. This nerve internal fascicle 3D reconstruction technology would be helpful for aiding peripheral nerve repair and virtual surgery. PMID:26596642

  8. Learning Effects of an International Group Competition Project

    ERIC Educational Resources Information Center

    Akpinar, Murat; del Campo, Cristina; Eryarsoy, Enes

    2015-01-01

    This study investigates the effects of collaboration and competition on students' learning performance in a course of business statistics. The collaboration involved a simultaneously organised group competition project with analysis of real-life business problems among students. Students from the following schools participated: JAMK…

  9. PREFACE: XXXth International Colloquium on Group Theoretical Methods in Physics (ICGTMP) (Group30)

    NASA Astrophysics Data System (ADS)

    Brackx, Fred; De Schepper, Hennie; Van der Jeugt, Joris

    2015-04-01

    The XXXth International Colloquium on Group Theoretical Methods in Physics (ICGTMP), also known as the Group30 conference, took place in Ghent (Belgium) from Monday 14 to Friday 18 July 2014. The conference was organised by Ghent University (Department of Applied Mathematics, Computer Science and Statistics, and Department of Mathematical Analysis). The website http://www.group30.ugent.be is still available. The ICGTMP is one of the traditional conference series covering the most important topics of symmetry which are relevant to the interplay of present-day mathematics and physics. More than 40 years ago a group of enthusiasts, headed by H. Bacry of Marseille and A. Janner of Nijmegen, initiated a series of annual meetings with the aim to provide a common forum for scientists interested in group theoretical methods. At that time most of the participants belonged to two important communities: on the one hand solid state specialists, elementary particle theorists and phenomenologists, and on the other mathematicians eager to apply newly-discovered group and algebraic structures. The conference series has become a meeting point for scientists working at modelling physical phenomena through mathematical and numerical methods based on geometry and symmetry. It is considered as the oldest one among the conference series devoted to geometry and physics. It has been further broadened and diversified due to the successful applications of geometric and algebraic methods in life sciences and other areas. The first four meetings took place alternatively in Marseille and Nijmegen. Soon after, the conference acquired an international standing, especially following the 1975 colloquium in Nijmegen and the 1976 colloquium in Montreal. Since then it has been organized in many places around the world. It has become a bi-annual colloquium since 1990, the year it was organized in Moscow. This was the first time the colloquium took place in Belgium. There were 246 registered

  10. Volcanic influences: International working group on volcanogenic sediments

    NASA Astrophysics Data System (ADS)

    A conclusion of the Geological Society of America Penrose Conference on Volcanic Influences on Terrestrial Sedimentation (August 28 to September 2, 1988) was that establishment of an informal working group would enhance our understanding of volcanogenic sedimentation. To establish the group, an ad hoc steering committee was formed at the conference and consists of W. J. Fritz (Georgia State University), R. S. Hildebrand (Geological Survey of Canada), R. Iverson (U.S. Geological Survey), P. Kokelaar (Chairman, University of Liverpool), T. C. Pierson (USGS), and G. A. Smith (University of New Mexico). The working group is open to researchers of any nation interested in the study of secondary transport and deposition of volcaniclastic materials in subaerial or subaqueous environments (e.g., transport, deposition, nomenclature, volcanic history, experiment, theory, hazard).

  11. 76 FR 55954 - Astralis Ltd., Cavit Sciences, Inc., Crystal International Travel Group, Inc., and Tasker...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Astralis Ltd., Cavit Sciences, Inc., Crystal International Travel Group, Inc., and Tasker Products... accurate information concerning the securities of Crystal International Travel Group, Inc. because it...

  12. PREFACE: XXXth International Colloquium on Group Theoretical Methods in Physics (ICGTMP) (Group30)

    NASA Astrophysics Data System (ADS)

    Brackx, Fred; De Schepper, Hennie; Van der Jeugt, Joris

    2015-04-01

    The XXXth International Colloquium on Group Theoretical Methods in Physics (ICGTMP), also known as the Group30 conference, took place in Ghent (Belgium) from Monday 14 to Friday 18 July 2014. The conference was organised by Ghent University (Department of Applied Mathematics, Computer Science and Statistics, and Department of Mathematical Analysis). The website http://www.group30.ugent.be is still available. The ICGTMP is one of the traditional conference series covering the most important topics of symmetry which are relevant to the interplay of present-day mathematics and physics. More than 40 years ago a group of enthusiasts, headed by H. Bacry of Marseille and A. Janner of Nijmegen, initiated a series of annual meetings with the aim to provide a common forum for scientists interested in group theoretical methods. At that time most of the participants belonged to two important communities: on the one hand solid state specialists, elementary particle theorists and phenomenologists, and on the other mathematicians eager to apply newly-discovered group and algebraic structures. The conference series has become a meeting point for scientists working at modelling physical phenomena through mathematical and numerical methods based on geometry and symmetry. It is considered as the oldest one among the conference series devoted to geometry and physics. It has been further broadened and diversified due to the successful applications of geometric and algebraic methods in life sciences and other areas. The first four meetings took place alternatively in Marseille and Nijmegen. Soon after, the conference acquired an international standing, especially following the 1975 colloquium in Nijmegen and the 1976 colloquium in Montreal. Since then it has been organized in many places around the world. It has become a bi-annual colloquium since 1990, the year it was organized in Moscow. This was the first time the colloquium took place in Belgium. There were 246 registered

  13. Design, conduct, and analyses of Breast International Group (BIG) 1-98: A randomized, double-blind, phase-III study comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive, early breast cancer

    PubMed Central

    Giobbie-Hurder, Anita; Price, Karen N; Gelber, Richard D

    2010-01-01

    Background Aromatase inhibitors provide superior disease control when compared with tamoxifen as adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer. Purpose To present the design, history, and analytic challenges of the Breast International Group (BIG) 1-98 trial: an international, multicenter, randomized, double-blind, phase-III study comparing the aromatase inhibitor letrozole with tamoxifen in this clinical setting. Methods From 1998–2003, BIG 1-98 enrolled 8028 women to receive monotherapy with either tamoxifen or letrozole for 5 years, or sequential therapy of 2 years of one agent followed by 3 years of the other. Randomization to one of four treatment groups permitted two complementary analyses to be conducted several years apart. The first, reported in 2005, provided a head-to-head comparison of letrozole versus tamoxifen. Statistical power was increased by an enriched design, which included patients who were assigned sequential treatments until the time of the treatment switch. The second, reported in late 2008, used a conditional landmark approach to test the hypothesis that switching endocrine agents at approximately 2 years from randomization for patients who are disease-free is superior to continuing with the original agent. Results The 2005 analysis showed the superiority of letrozole compared with tamoxifen. The patients who were assigned tamoxifen alone were unblinded and offered the opportunity to switch to letrozole. Results from other trials increased the clinical relevance about whether or not to start treatment with letrozole or tamoxifen, and analysis plans were expanded to evaluate sequential versus single-agent strategies from randomization. Limitations Due to the unblinding of patients assigned tamoxifen alone, analysis of updated data will require ascertainment of the influence of selective crossover from tamoxifen to letrozole. Conclusions BIG 1-98 is an example of an enriched design, involving

  14. Comparing International Curriculum Systems: The International Instructional Systems Study

    ERIC Educational Resources Information Center

    Creese, Brian; Gonzalez, Alvaro; Isaacs, Tina

    2016-01-01

    This paper sets out the main findings of the International Instructional Systems Study (IISS), conducted by the UCL Institute of Education and funded by the Center on International Education Benchmarking (CIEB). The study examined the instructional systems and intended curricula of six "high performing" countries and two US states. The…

  15. Group Performance in Information Systems Project Groups: An Empirical Study

    ERIC Educational Resources Information Center

    Bahli, Bouchaib; Buyukkurt, Meral Demirbag

    2005-01-01

    The importance of teamwork in Information Systems Development (ISD) practice and education has been acknowledged but not studied extensively to date. This paper tests a model of how groups participating in ISD projects perform and examines the relationships between some antecedents of this performance based on group research theory well…

  16. The Effects of Structured and Unstructured Leader Roles on Internal and External Group Participants

    ERIC Educational Resources Information Center

    Kilmann, Peter R.; Sotile, Wayne M.

    1976-01-01

    It was predicted that external Ss in the structured group would rate the leader and the group more positively than would internal Ss, and that internal Ss in the unstructured group would rate the leader and the group more positively than would external Ss. (Author)

  17. Robotic, laparoscopic and open surgery for gastric cancer compared on surgical, clinical and oncological outcomes: a multi-institutional chart review. A study protocol of the International study group on Minimally Invasive surgery for GASTRIc Cancer—IMIGASTRIC

    PubMed Central

    Desiderio, Jacopo; Jiang, Zhi-Wei; Nguyen, Ninh T; Zhang, Shu; Reim, Daniel; Alimoglu, Orhan; Azagra, Juan-Santiago; Yu, Pei-Wu; Coburn, Natalie G; Qi, Feng; Jackson, Patrick G; Zang, Lu; Brower, Steven T; Kurokawa, Yukinori; Facy, Olivier; Tsujimoto, Hironori; Coratti, Andrea; Annecchiarico, Mario; Bazzocchi, Francesca; Avanzolini, Andrea; Gagniere, Johan; Pezet, Denis; Cianchi, Fabio; Badii, Benedetta; Novotny, Alexander; Eren, Tunc; Leblebici, Metin; Goergen, Martine; Zhang, Ben; Zhao, Yong-Liang; Liu, Tong; Al-Refaie, Waddah; Ma, Junjun; Takiguchi, Shuji; Lequeu, Jean-Baptiste; Trastulli, Stefano; Parisi, Amilcare

    2015-01-01

    Introduction Gastric cancer represents a great challenge for healthcare providers and requires a multidisciplinary treatment approach in which surgery plays a major role. Minimally invasive surgery has been progressively developed, first with the advent of laparoscopy and recently with the spread of robotic surgery, but a number of issues are currently being debated, including the limitations in performing an effective extended lymph node dissection, the real advantages of robotic systems, the role of laparoscopy for Advanced Gastric Cancer, the reproducibility of a total intracorporeal technique and the oncological results achievable during long-term follow-up. Methods and analysis A multi-institutional international database will be established to evaluate the role of robotic, laparoscopic and open approaches in gastric cancer, comprising of information regarding surgical, clinical and oncological features. A chart review will be conducted to enter data of participants with gastric cancer, previously treated at the participating institutions. The database is the first of its kind, through an international electronic submission system and a HIPPA protected real time data repository from high volume gastric cancer centres. Ethics and dissemination This study is conducted in compliance with ethical principles originating from the Helsinki Declaration, within the guidelines of Good Clinical Practice and relevant laws/regulations. A multicentre study with a large number of patients will permit further investigation of the safety and efficacy as well as the long-term outcomes of robotic, laparoscopic and open approaches for the management of gastric cancer. Trial registration number NCT02325453; Pre-results. PMID:26482769

  18. Internal rotation of the methyl group in the radical cation of dimethyl ether

    NASA Astrophysics Data System (ADS)

    Matsushita, Michio; Momose, Takamasa; Shida, Tadamasa

    1990-04-01

    The radical cation of dimethyl ether has been studied by ESR in the temperature region of 6-140 K for focusing on the internal rotation of the methyl groups. The methyl groups rotate almost freely at above 70 K to give a septet ESR spectrum. At temperatures below 40 K there emerge extra lines due to the tunneling rotation of the methyl groups. From the analysis of the line shape, the interaction potential for the rotation of the two methyl groups, if any, should be approximated as proportional to cos 3theta1 cos 3theta2, where theta1 and theta2 denote the rotational angles of the methyl groups measured from the potential minima of the internal rotation of the methyl groups. The activation energy for the thermally induced internal rotation is determined to be about 100 cal/mol at temperatures above 25 K, whereas at lower temperatures the apparent activation energy drops sharply, which is consistent with the quantum tunneling of the methyl protons. The small activation energy of 100 cal/mol for the radical cation is compatible with the result of ab initio MO calculation for the potential barrier.

  19. Results of a Quality Assurance Review of External Beam Radiation Therapy in the International Society of Paediatric Oncology (Europe) Neuroblastoma Group's High-risk Neuroblastoma Trial: A SIOPEN Study

    SciTech Connect

    Gaze, Mark N.; Boterberg, Tom; Dieckmann, Karin; Hoermann, Marcus; Gains, Jennifer E.; Sullivan, Kevin P.; Ladenstein, Ruth

    2013-01-01

    Purpose: Radiation therapy is important for local control in neuroblastoma. This study reviewed the compliance of plans with the radiation therapy guidelines of the International Society of Paediatric Oncology (Europe) Neuroblastoma Group (SIOPEN) High-Risk Trial protocol. Methods and Materials: The SIOPEN trial central electronic database has sections to record diagnostic imaging and radiation therapy planning data. Individual centers may upload data remotely, but not all centers involved in the trial chose to use this system. A quality scoring system was devised based on how well the radiation therapy plan matched the protocol guidelines, to what extent deviations were justified, and whether adverse effects may result. Central review of radiation therapy planning was undertaken retrospectively in 100 patients for whom complete diagnostic and treatment sets were available. Data were reviewed and compared against protocol guidelines by an international team of radiation oncologists and radiologists. For each patient in the sample, the central review team assigned a quality assurance score. Results: It was found that in 48% of patients there was full compliance with protocol requirements. In 29%, there were deviations for justifiable reasons with no likely long-term adverse effects resulting. In 5%, deviations had occurred for justifiable reasons, but that might result in adverse effects. In 1%, there was a deviation with no discernible justification, which would not lead to long-term adverse events. In 17%, unjustified deviations were noted, with a risk of an adverse outcome resulting. Conclusions: Owing to concern over the proportion of patients in whom unjustified deviations were observed, a protocol amendment has been issued. This offers the opportunity for central review of radiation therapy plans before the start of treatment and the treating clinician a chance to modify plans.

  20. Comparison of performance of the Assessment of SpondyloArthritis International Society, the European Spondyloarthropathy Study Group and the modified New York criteria in a cohort of Chinese patients with spondyloarthritis.

    PubMed

    Chung, Ho Yin; Lau, Chak Sing; Wu, Ka Pik; Wong, Woon Sing; MOK, Mo Yin

    2011-07-01

    Early diagnosis of spondyloarthritis (SpA) is essential as anti-tumor necrosis factor therapy can achieve significant symptomatic relief and control of disease activity. This study aims to compare the clinical characteristics, disease activity, and functional status of a Chinese cohort of SpA patients who were re-classified into ankylosing spondylitis (AS) patients fulfilling the modified New York (MNY) criteria, those with undifferentiated SpA (USpA) fulfilling the European Spondyloarthropathy Study Group (ESSG) classification criteria only (USpA/ESSG) and those who fulfill Assessment of SpondyloArthritis International Society (ASAS) only (USpA/ASAS). Disease activity was evaluated by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), severity of morning stiffness, patient global assessment, and C-reactive protein. Functional status was evaluated by Bath Ankylosing Spondylitis Functional Index (BASFI), modified Schober index, and dimension of chest expansion. One hundred and twenty-eight patients with disease duration of 16.3 ± 10.4 years were recruited. Patients in USpA/ESSG and USpA/ASAS were significantly younger (p = 0.01), had shorter disease duration (p < 0.01), and lower BASFI (p = 0.03) than established AS patients. All three groups have active disease with comparable BASDAI >3. BASFI correlated inversely with dimension of chest expansion and negatively modified Schober index in AS patients (p < 0.01) and modestly with BASDAI (r = 0.25, p < 0.01). BASFI correlated moderately with BASDAI in USpA/ESSG (r = 0.61, p < 0.01) but not with chest expansion or modified Schober index. Compared with established AS patients recognized by MNY criteria, patients fulfilling USpA defined by ESSG or ASAS criteria had earlier disease, as active disease and less irreversible functional deficit. PMID:21336823

  1. Report from International Lunar Exploration Working Group (ILEWG) to COSPAR

    NASA Astrophysics Data System (ADS)

    Foing, Bernard H.

    inputs to future missions, including a gap analysis of needed measurements. Highly resolved global data sets are required. Autonomous landing and hazard avoidance will depend on the best topographic map of the Moon, achievable by combining shared data. - New topics such as life sciences, partial gravity processes on the Moon should be followed in relation to future exploration needs.” http://sci.esa.int/ilewg/ http://sci.esa.int/ilewg/47170-gluc-iceum11-beijing-2010lunar-declaration/ References: [1] 1st International Lunar Workshop, Balsiger H. et al., Editors, European Space Agency, 1994. ESA-SP-1170. [2] 2nd International Lunar Workshop, Kyoto, H. Mizutani, editor, Japan Space Forum Publisher, 1997. [3] 3rd International Lunar Workshop, Moscow 1998, E. Galimov, editor. [4] ICEUM4, ESTEC, 2000, ESA SP-462, B.H. Foing & M. Perry, editors. [5] ICEUM5, Hawaii Nov 2003, Durst S.M. et al, Editors, Vol 108, 1-576 pp, Science and Technology Series, American Astronautical Society, 2004. [6] ICEUM6, Udaipur 2004, Bhandari N., Editor, Journal Earth Sys-tem Science, India, 114, No6, Dec 2005, pp. 573-841. [7] ICEUM7, Toronto Sept 2005, sci.esa.int/ilewg. [8] ICEUM8, Beijing July 2006, Journal of Chinese Society of Astronautics, Vol. 28 Sup., 2007, Ji W., Editor. [9] ICEUM9, Sorrento, Italy, Foing B., Espinasse S., Kosters G., Editors. http://sci.esa.int/iceum9, Dec. 2007), [11] Ehrenfreund, P., Foing, B.H., Cellino, A. Editors, The Moon and Near Earth Objects, ASR Vol 37, 1, 2006. [12] Foing, B.H. et al editors, 'Astronomy and Space Science from the Moon', ASR 14, 6, 1994. [13] Ip W.-H., Foing, B.H., Masson Ph.L., editors, The Moon and Mars, ASR Vol 23, 11, 1999. [14] Foing, B.H. et al, editor, Lunar Exploration, Planetary and Space Science, Vol 50, 14-15, 2002. [15] Foing, B.H., Heather, D. editors, 'Lunar Exploration 2000', ASR Vol 30, Nr 8, 2002. [16] Huntress, W. et al 'The next steps in exploring deep space - A cosmic study by the IAA', Acta Astronautica, Vol 58, Issues 6

  2. Spectroscopic investigation of the vibrational quasi-continuum arising from internal rotation of a methyl group

    SciTech Connect

    Hougen, J.T.

    1993-12-01

    The goal of this project is to use spectroscopic techniques to investigate in detail phenomena involving the vibrational quasi-continuum in a simple physical system. Acetaldehyde was chosen for the study because: (i) methyl groups have been suggested to be important promotors of intramolecular vibrational relaxation, (ii) the internal rotation of a methyl group is an easily describle large-amplitude motion, which should retain its simple character even at high levels of excitation, and (iii) the aldehyde carbonyl group offers the possibility of both vibrational and electronic probing. The present investigation of the ground electronic state has three parts: (1) understanding the {open_quotes}isolated{close_quotes} internal-rotation motion below, at, and above the top of the torsional barrier, (2) understanding in detail traditional (bond stretching and bending) vibrational fundamental and overtone states, and (3) understanding interactions involving states with multiquantum excitations of at least one of these two kinds of motion.

  3. DPHEP: From Study Group to Collaboration

    NASA Astrophysics Data System (ADS)

    Shiers, Jamie

    2014-06-01

    The international study group on data preservation in High Energy Physics, DPHEP, achieved a major milestone in 2012 with the publication of its eagerly anticipated large-scale report [1]. This document contains a description of data preservation activities from all major high energy physics collider-based experiments and laboratories. A central message of the report is that data preservation in HEP is not possible without long term investment in not only hardware but also human resources, and with this in mind DPHEP will evolve to a new collaboration structure in 2013. This paper describes the progress made since the publication of that report - shortly before CHEP 2012 - as well as the future working directions of the new collaboration.

  4. Internal consistency of the self-reporting questionnaire-20 in occupational groups

    PubMed Central

    Santos, Kionna Oliveira Bernardes; Carvalho, Fernando Martins; de Araújo, Tânia Maria

    2016-01-01

    ABSTRACT OBJECTIVE To assess the internal consistency of the measurements of the Self-Reporting Questionnaire (SRQ-20) in different occupational groups. METHODS A validation study was conducted with data from four surveys with groups of workers, using similar methods. A total of 9,959 workers were studied. In all surveys, the common mental disorders were assessed via SRQ-20. The internal consistency considered the items belonging to dimensions extracted by tetrachoric factor analysis for each study. Item homogeneity assessment compared estimates of Cronbach’s alpha (KD-20), the alpha applied to a tetrachoric correlation matrix and stratified Cronbach’s alpha. RESULTS The SRQ-20 dimensions showed adequate values, considering the reference parameters. The internal consistency of the instrument items, assessed by stratified Cronbach’s alpha, was high (> 0.80) in the four studies. CONCLUSIONS The SRQ-20 showed good internal consistency in the professional categories evaluated. However, there is still a need for studies using alternative methods and additional information able to refine the accuracy of latent variable measurement instruments, as in the case of common mental disorders. PMID:27007682

  5. Cerulean Warbler Technical Group: Coordinating international research and conservation

    USGS Publications Warehouse

    Dawson, D.K.; Wigley, T.B.; Keyser, P.D.

    2012-01-01

    Effective conservation for species of concern requires interchange and collaboration among conservationists and stakeholders. The Cerulean Warbler Technical Group (CWTG) is a consortium of biologists and managers from government agencies, non-governmental organizations, academia, and industry, who are dedicated to finding pro-active, science-based solutions for conservation of the Cerulean Warbler (Setophaga cerulea). Formed in the United States in 2001, CWTG’s scope soon broadened to address the species’ ecology and conservation on both the breeding and non-breeding ranges, in partnership with biologists from South and Central America. In 2004, CWTG launched the Cerulean Warbler Conservation Initiative, a set of activities aimed at addressing information and conservation needs for the species. These include (1) studies in the core breeding range to assess Cerulean Warbler response to forest management practices and to identify mined lands that could be reforested to benefit the species, (2) ecological and demographic studies on the winter range, and (3) surveys of Cerulean Warbler distribution on the breeding and winter ranges and during migration. A rangewide conservation action plan has been completed, along with a more detailed conservation plan for the non-breeding range. CWTG and partners now move forward with on-the-ground conservation, while still addressing unmet information needs.

  6. Is adjuvant chemotherapy of benefit for postmenopausal women who receive endocrine treatment for highly endocrine-responsive, node-positive breast cancer? International Breast Cancer Study Group Trials VII and 12-93.

    PubMed

    Pagani, Olivia; Gelber, Shari; Simoncini, Edda; Castiglione-Gertsch, Monica; Price, Karen N; Gelber, Richard D; Holmberg, Stig B; Crivellari, Diana; Collins, John; Lindtner, Jurij; Thürlimann, Beat; Fey, Martin F; Murray, Elizabeth; Forbes, John F; Coates, Alan S; Goldhirsch, Aron

    2009-08-01

    To compare the efficacy of chemoendocrine treatment with that of endocrine treatment (ET) alone for postmenopausal women with highly endocrine responsive breast cancer. In the International Breast Cancer Study Group (IBCSG) Trials VII and 12-93, postmenopausal women with node-positive, estrogen receptor (ER)-positive or ER-negative, operable breast cancer were randomized to receive either chemotherapy or endocrine therapy or combined chemoendocrine treatment. Results were analyzed overall in the cohort of 893 patients with endocrine-responsive disease, and according to prospectively defined categories of ER, age and nodal status. STEPP analyses assessed chemotherapy effect. The median follow-up was 13 years. Adding chemotherapy reduced the relative risk of a disease-free survival event by 19% (P = 0.02) compared with ET alone. STEPP analyses showed little effect of chemotherapy for tumors with high levels of ER expression (P = 0.07), or for the cohort with one positive node (P = 0.03). Chemotherapy significantly improves disease-free survival for postmenopausal women with endocrine-responsive breast cancer, but the magnitude of the effect is substantially attenuated if ER levels are high. PMID:18953651

  7. Effects of Group Work on English Communicative Competence of Chinese International Graduates in United States Institutions of Higher Education

    ERIC Educational Resources Information Center

    Xue, Mo

    2013-01-01

    This qualitative study investigated 14 Chinese international graduate students' lived experiences with group work and the effects of group work on their English communicative competence. The interview results showed that these participants' attitudes towards group work went through changes from initial inadaptation or dislike to later adaptation…

  8. 76 FR 14105 - International Paper Company, Pineville Mill Industrial Packaging Group; Pineville, LA; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-15

    ... October 29, 2010 (75 FR 66795). The subject workers produce containerboard/paperboard (uncoated freesheet... Employment and Training Administration International Paper Company, Pineville Mill Industrial Packaging Group... workers and former workers of International Paper Company, Pineville Mill, Industrial Packaging...

  9. Group Counseling with International Students: Practical, Ethical, and Cultural Considerations

    ERIC Educational Resources Information Center

    Yakunina, Elena S.; Weigold, Ingrid K.; McCarthy, Alannah S.

    2011-01-01

    International students in higher education represent a diverse population with unique mental health needs. Foreign students commonly experience a host of adjustment issues, including acculturative stress, language difficulties, cultural misunderstandings, racial discrimination, and loss of social support. Despite their challenges, few…

  10. Southeastern Cancer Study Group: breast cancer studies

    SciTech Connect

    Smalley, R.V.; Bartolucci, A.A.; Moore, M.

    1983-12-01

    During the past 10 years, the Southeastern Cancer Study Group (SECSG) has been engaged in one major adjuvant study and three major advanced disease studies for patients with adenocarcinoma of the breast. The adjuvant study is demonstrating that six months of adjuvant CMF is the therapeutic equivalent of 12 months and that post-operative irradiation is of no added therapeutic benefit. In patients with advanced disease, a low dose 5 drug combination of CMFVP induces more objective responses than single agent 5FU, but improves survival only for those patients with liver metastases when compared to the sequential use of the same 5 single agents. The three drug combination, CAF, utilizing doxorubicin, induces more objective responses than low dose CMFVP, but it does not improve overall survival. The addition of a phase active combination, CAMELEON, (i.e., sequentially alternating therapy) of CAF has not improved the duration of disease control and survival for patients with liver metastases, lymphangitic and nodular lung metastases compared to CAF. Aggressive combination chemotherapeutic approaches to patients with advanced disease provide better and longer disease and tumor control but only marginal improvements in overall survival. Adding additional agents to a maximally tolerable regimen has not improved the therapeutic outcome.

  11. [International project--MGTX study].

    PubMed

    Yoshikawa, Hiroaki

    2007-11-01

    MGTX Study is a multi-center, international, single-blinded, randomized trial to determine whether extended transsternal thymectomy (ETTX) for patients with myasthenia gravis receiving the prednisone protocol confers added benefits to the prednisone protocol alone. The aims of the study are answering following three questions. 1) Does ETTX combined with prednisone result in a greater improvement in myasthenic weakness, compared to prednisone alone? 2) Does ETTX combined with prednisone result in a lower total dose of prednisone, thus decreasing the likelihood of concurrent and long-term toxic effects, compared to prednisone alone? 3) Does ETTX combined with prednisone enhance quality of life by reducing adverse events and symptoms associated with the therapies, compared to prednisone alone? Primary outcome measure is consists with 1) Comparison of the prednisone protocol alone to prednisone protocol plus ETTX, based on the clinical response to therapy measured over the 3 year trial period by the Area Under the Quantitative Myasthenia Gravis (QMG) Weakness Score (AUQMG), and 2) Testing the difference in the total prednisone used over the 3 year trial period measured by pill count from blister packs (Area Under the Prednisone Dose Time Curve, AUDTC), conditional on the results of comparing AUQMG. PMID:18210825

  12. Breaking Cycles of Violence. A Work Group of the International Work Group on Death, Dying and Bereavement (IWG)

    ERIC Educational Resources Information Center

    Death Studies, 2005

    2005-01-01

    Violence begets violence and it is important to understand how cycles of violence are perpetuated if we are to find solutions to the global problems they present. A multi-disciplinary group of The International Work Group on Death, Dying and Bereavement has developed a model of the cyclical events that perpetuate violence at all levels including…

  13. Cognitive Behavioral Principles Within Group Mentoring: A Randomized Pilot Study

    PubMed Central

    JENT, JASON F.; NIEC, LARISSA N.

    2010-01-01

    This study evaluated the effectiveness of a group mentoring program that included components of empirically supported mentoring and cognitive behavioral techniques for children served at a community mental health center. Eighty-six 8- to 12-year-old children were randomly assigned to either group mentoring or a wait-list control group. Group mentoring significantly increased children’s reported social problem-solving skills and decreased parent-reported child externalizing and internalizing behavior problems after controlling for other concurrent mental health services. Attrition from the group mentoring program was notably low (7%) for children. The integration of a cognitive behavioral group mentoring program into children’s existing community mental health services may result in additional reductions in externalizing and internalizing behavior problems. PMID:20582243

  14. International Consultation and Training on Group Work in South Asia

    ERIC Educational Resources Information Center

    Ibrahim, Farah A.

    2015-01-01

    This article presents a consultation and training for faculty and graduate students in South Asia under the auspices of the United Nations' Transfer of Knowledge Through Expatriate Nationals (TOKTEN) Program. It describes the development of a consultation relationship and training on group work. Needs assessments focusing on both cultural…

  15. 75 FR 26794 - Alticor, Inc., Including Access Business Group International LLC and Amway Corporation, Buena...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Alticor, Inc., Including Access Business Group International LLC and Amway Corporation, Buena Park, CA; Alticor, Inc., Including Access Business Group International LLC, and Amway Corporation, Ada, MI;...

  16. 76 FR 54520 - Somerset International Group, Inc.; Order of Suspension of Trading

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Somerset International Group, Inc.; Order of Suspension of Trading August 30, 2011. It appears to... concerning the securities of Somerset International Group, Inc. The Commission is of the opinion that...

  17. Computer-Assisted International Studies.

    ERIC Educational Resources Information Center

    Wilkenfeld, Jonathan

    1983-01-01

    Describes an interdisciplinary college level program which uses computer simulation exercises to teach about foreign policy and global issues. In the foreign policy simulation, political science and foreign language students role play national decision makers. In the international futures simulation, students debate demographic, economic, energy,…

  18. International Study of Marketing Education.

    ERIC Educational Resources Information Center

    Liander, Bertil, Ed.

    The International Marketing Federation (IMF), supported by the Marketing Science Institute, has surveyed IMF member countries and a representative scattering of others to determine the current state and future trends in marketing education. This volume presents the findings of the survey of 21 countries--Argentina, Australia, Canada, Denmark,…

  19. Developing International Business Managers through International Study Visits to China

    ERIC Educational Resources Information Center

    Tang, Yiming; Rose, Susan

    2014-01-01

    Globalization is a key factor in the success of business organizations today, impacting many aspects of management performance. Understanding the global business environment has therefore become a key objective in the teaching of international business on Executive MBA programs. Drawing on the theory of experiential learning, this study examines…

  20. Abstracts from the 2016 Joint Meeting of the International Confocal Group (ICG), the International Dermoscopy Society (IDS), and the International Society for Digital Imaging of the Skin (ISDIS)

    PubMed Central

    2016-01-01

    What follows are the abstracts presented at the Joint Meeting of the International Confocal Group (ICG), the International Dermoscopy Society (IDS), and the International Society for Digital Imaging of the Skin (ISDIS). The meeting was held on March 5, 2016, in Washington, DC, USA, in conjunction with the annual meeting of the American Academy of Dermatology (Figure 1). The abstracts appear in the order in which they were presented.

  1. IAU Working Group on International Data Access for Solar and Heliospheric data

    NASA Astrophysics Data System (ADS)

    Bentley, R. D.; Hill, F.; Hurlburt, N.; Roberts, A.

    2004-05-01

    Division II (Sun and Heliosphere) of the IAU has initiated a Working Group to study the archiving, retrieval and distribution of solar and heliospheric data. The goal of the Working Group is to facilitate the use of available solar and heliospheric data that are archived in a large number of computers scattered all over the world. The intent of the Working Group is to help coordinate the existing and growing data exchange through the Internet and work with the virtual observatory initiatives to propose guidelines for exchange at an international level and encourage participation in the projects. The Working Group is working with the virtual observatory initiatives to ensure that they develop standards and employ techniques that are acceptable to the worldwide solar and heliospheric communities and to encourage interoperability between the projects. The EGSO, VSO, CoSEC and VSPO projects are all part of the Working Group and would also like to encourage the communities to help develop standards and participate in the virtual observatory projects. The aims of and objectives the Working Group will be discussed and feedback from the audience is encouraged.

  2. Methyl Group Internal Rotation in the Pure Rotational Spectrum of 1,1-DIFLUOROACETONE

    NASA Astrophysics Data System (ADS)

    Grubbs, G. S. Grubbs, II; Cooke, S. A.; Groner, P.

    2011-06-01

    We have used chirped pulse Fourier transform microwave spectroscopy to record the pure rotational spectrum of the title molecule. The spectrum was doubled owing to the internal rotation of the methyl group. The spectrum has been assigned and two approaches to the spectral analysis have been performed. In the first case, the A and E components were fit separately using a principal axis method with the SPFIT code of Pickett. In the second case, the A and E states were fit simultaneously using the ERHAM code. For a satisfactory analysis of the spectral data it has been found that the choice of Hamiltonian reduction, i.e. Watson A or S, is very important. The barrier to the internal rotation has been determined to be 261.1(8) Cm-1 and it will be compared to that of acetone and other halogenated acetone species recently studied in our laboratory.

  3. Asian International Students in Counseling Programs: A Group Intervention to Promote Social Justice

    ERIC Educational Resources Information Center

    Delgado-Romero, Edward A.; Wu, Yi-Chen

    2010-01-01

    A group designed to address social justice issues for Asian international students within a counseling training program is described. The authors implemented such a group that led to critical consciousness, accountability, and action spurred by culturally sensitive empowerment. Such a group may be desirable for training programs that want to…

  4. The internal dynamics of environmental organizations: Movement interest groups, communal advocacy groups, and the policy process

    SciTech Connect

    Shaffer, M.B.

    1995-12-31

    How do the diverse qualities that movement organizations bring to the policy process affect the representation of particular interests? This question is explored by analyzing environmental organizations across the national, state, and local levels of the American political system. This article suggests that two types of social movement organizations exist: movement interest groups and communal advocacy groups. While this article does not provide direct evidence of the different policy capabilities of the two types of movement organizations, existing research is drawn upon to consider how each type might fare in the policy process. One approach suggests that centralized organizations with incremental goals are better equipped to attain policy success, while the other stresses the need for active member involvement to engage in disruptive politics. To fully assess these divergent views, this article presents a broad review and analysis of the literature.

  5. Facebook Groups as LMS: A Case Study

    ERIC Educational Resources Information Center

    Meishar-Tal, Hagit; Kurtz, Gila; Pieterse, Efrat

    2012-01-01

    This paper describes a pilot study in using Facebook as an alternative to a learning management system (LMS). The paper reviews the current research on the use of Facebook in academia and analyzes the differences between a Facebook group and a regular LMS. The paper reports on a precedent-setting attempt to use a Facebook group as a course…

  6. Examining Effectiveness of Group Cognitive-Behavioral Therapy for Externalizing and Internalizing Disorders in Urban Schools.

    PubMed

    Eiraldi, Ricardo; Power, Thomas J; Schwartz, Billie S; Keiffer, Jackie N; McCurdy, Barry L; Mathen, Manju; Jawad, Abbas F

    2016-07-01

    This article presents outcome data of the implementation of three group cognitive-behavioral therapy (GCBT) interventions for children with externalizing behavior problems, anxiety, and depression. School counselors and graduate students co-led the groups in two low-income urban schools. Data were analyzed to assess pre-treatment to post-treatment changes in diagnostic severity level. Results of the exploratory study indicated that all three GCBT protocols were effective at reducing diagnostic severity level for children who had a primary diagnosis of an externalizing disorder, anxiety disorder, or depressive disorder at the clinical or intermediate (at-risk) level. All three GCBT protocols were implemented with relatively high levels of fidelity. Data on the effectiveness of the interventions for reducing diagnostic severity level for externalizing and internalizing spectrum disorders and for specific disorders are presented. A discussion of implementation of mental health evidence-based interventions in urban schools is provided. PMID:26872957

  7. Division XII / Commission 46 / Program Group International Schools for Young Astronomers

    NASA Astrophysics Data System (ADS)

    De Greve, Jean-Pierre; Leung, Kam-Ching; Gerbaldi, Michèle

    The IAU Commission 46 Program Group International Schools for Young Astronomers (ISYA) was created in 1967 (Gerbaldi 2008). During the period 2006 till August 2008 two ISYAs took place, one in Malaysia and a second one in Turkey.

  8. Australian and International Student Success Rates in Group of Eight Universities. Go8 Backgrounder 5

    ERIC Educational Resources Information Center

    Group of Eight (NJ1), 2008

    2008-01-01

    This Go8 Backgrounder compares the academic performance of three cohorts of students in Group of Eight (Go8) universities: Australian students, international students on campus in Australia (onshore) and international students overseas (offshore). Analysis of data supplied by Go8 universities shows that in 2007 students passed 91.8% of the courses…

  9. Fostering Collaborative Teaching and Learning Scholarship through an International Writing Group Initiative

    ERIC Educational Resources Information Center

    Marquis, Elizabeth; Healey, Mick; Vine, Michelle

    2016-01-01

    The research presented here explored the experiences of participants in an international collaborative writing group (ICWG) initiative that ran in conjunction with the 2012 International Society for the Scholarship of Teaching and Learning (ISSoTL) conference. The ICWG sought to cultivate collaborative pedagogical scholarship by bringing together…

  10. Comparison of the Masaoka-Koga staging and the International Association for the Study of Lung Cancer/the International Thymic Malignancies Interest Group proposal for the TNM staging systems based on the Chinese Alliance for Research in Thymomas retrospective database

    PubMed Central

    Liang, Guanghui; Gu, Zhitao; Fu, Jianhua; Shen, Yi; Wei, Yucheng; Tan, Lijie; Zhang, Peng; Han, Yongtao; Chen, Chun; Zhang, Renquan; Chen, Keneng; Chen, Hezhong; Liu, Yongyu; Cui, Youbing; Wang, Yun; Pang, Liewen; Yu, Zhentao; Zhou, Xinming; Liu, Yangchun; Liu, Yuan

    2016-01-01

    Background To compare the predictive effect of the Masaoka-Koga staging system and the International Association for the Study of Lung Cancer (IASLC)/the International Thymic Malignancies Interest Group (ITMIG) proposal for the new TNM staging on prognosis of thymic malignancies using the Chinese Alliance for Research in Thymomas (ChART) retrospective database. Methods From 1992 to 2012, 2,370 patients in ChART database were retrospectively reviewed. Of these, 1,198 patients with complete information on TNM stage, Masaoka-Koga stage, and survival were used for analysis. Cumulative incidence of recurrence (CIR) was assessed in R0 patients. Overall survival (OS) was evaluated both in an R0 resected cohort, as well as in all patients (any R status). CIR and OS were first analyzed according to the Masaoka-Koga staging system. Then, they were compared using the new TNM staging proposal. Results Based on Masaoka-Koga staging system, significant difference was detected in CIR among all stages. However, no survival difference was revealed between stage I and II, or between stage II and III. Stage IV carried the highest risk of recurrence and worst survival. According to the new TNM staging proposal, CIR in T1a was significantly lower comparing to all other T categories (P<0.05) and there is a significant difference in OS between T1a and T1b (P=0.004). T4 had the worst OS comparing to all other T categories. CIR and OS were significantly worse in N (+) than in N0 patients. Significant difference in CIR and OS was detected between M0 and M1b, but not between M0 and M1a. OS was almost always statistically different when comparison was made between stages I–IIIa and stages IIIb–IVb. However, no statistical difference could be detected among stages IIIb to IVb. Conclusions Compared with Masaoka-Koga staging, the IASLC/ITMIG TNM staging proposal not only describes the extent of tumor invasion but also provides information on lymphatic involvement and tumor dissemination

  11. Conformational relaxation and water penetration coupled to ionization of internal groups in proteins.

    PubMed

    Damjanović, Ana; Brooks, Bernard R; García-Moreno, Bertrand

    2011-04-28

    Molecular dynamics simulations were used to examine the effects of ionization of internal groups on the structures of eighteen variants of staphylococcal nuclease (SNase) with internal Lys, Asp, or Glu. In most cases the RMSD values of internal ionizable side chains were larger when the ionizable moieties were charged than when they were neutral. Calculations of solvent-accessible surface area showed that the internal ionizable side chains were buried in the protein interior when they were neutral and moved toward crevices and toward the protein-water interface when they were charged. The only exceptions are Lys-36, Lys-62, and Lys-103, which remained buried even after charging. With the exception of Lys-38, the number of internal water molecules surrounding the ionizable group increased upon charging: the average number of water oxygen atoms within the first hydration shell increased by 1.7 for Lys residues, by 5.2 for Asp residues, and by 3.2 for Glu residues. The polarity of the microenvironment of the ionizable group also increased when the groups were charged: the average number of polar atoms of any kind within the first hydration shell increased by 2.7 for Lys residues, by 4.8 for Asp residues, and by 4.0 for Glu residues. An unexpected correlation was observed between the absolute value of the shifts in pK(a) values measured experimentally, and several parameters of structural relaxation: the net difference in the polarity of the microenvironment of the charged and neutral forms of the ionizable groups, the net difference in hydration of the charged and neutral forms of the ionizable groups, and the difference in RMSD values of the charged and neutral forms of the ionizable groups. The effects of ionization of internal groups on the conformation of the backbone were noticeable but mostly small and localized to the area immediately next to the internal ionizable moiety. Some variants did exhibit local unfolding. PMID:21428436

  12. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma.

    PubMed

    Rajkumar, S Vincent; Dimopoulos, Meletios A; Palumbo, Antonio; Blade, Joan; Merlini, Giampaolo; Mateos, María-Victoria; Kumar, Shaji; Hillengass, Jens; Kastritis, Efstathios; Richardson, Paul; Landgren, Ola; Paiva, Bruno; Dispenzieri, Angela; Weiss, Brendan; LeLeu, Xavier; Zweegman, Sonja; Lonial, Sagar; Rosinol, Laura; Zamagni, Elena; Jagannath, Sundar; Sezer, Orhan; Kristinsson, Sigurdur Y; Caers, Jo; Usmani, Saad Z; Lahuerta, Juan José; Johnsen, Hans Erik; Beksac, Meral; Cavo, Michele; Goldschmidt, Hartmut; Terpos, Evangelos; Kyle, Robert A; Anderson, Kenneth C; Durie, Brian G M; Miguel, Jesus F San

    2014-11-01

    This International Myeloma Working Group consensus updates the disease definition of multiple myeloma to include validated biomarkers in addition to existing requirements of attributable CRAB features (hypercalcaemia, renal failure, anaemia, and bone lesions). These changes are based on the identification of biomarkers associated with near inevitable development of CRAB features in patients who would otherwise be regarded as having smouldering multiple myeloma. A delay in application of the label of multiple myeloma and postponement of therapy could be detrimental to these patients. In addition to this change, we clarify and update the underlying laboratory and radiographic variables that fulfil the criteria for the presence of myeloma-defining CRAB features, and the histological and monoclonal protein requirements for the disease diagnosis. Finally, we provide specific metrics that new biomarkers should meet for inclusion in the disease definition. The International Myeloma Working Group recommends the implementation of these criteria in routine practice and in future clinical trials, and recommends that future studies analyse any differences in outcome that might occur as a result of the new disease definition. PMID:25439696

  13. International and national expert group evaluations: biological/health effects of radiofrequency fields.

    PubMed

    Vijayalaxmi; Scarfi, Maria R

    2014-09-01

    The escalated use of various wireless communication devices, which emit non-ionizing radiofrequency (RF) fields, have raised concerns among the general public regarding the potential adverse effects on human health. During the last six decades, researchers have used different parameters to investigate the effects of in vitro and in vivo exposures of animals and humans or their cells to RF fields. Data reported in peer-reviewed scientific publications were contradictory: some indicated effects while others did not. International organizations have considered all of these data as well as the observations reported in human epidemiological investigations to set-up the guidelines or standards (based on the quality of published studies and the "weight of scientific evidence" approach) for RF exposures in occupationally exposed individuals and the general public. Scientists with relevant expertise in various countries have also considered the published data to provide the required scientific information for policy-makers to develop and disseminate authoritative health information to the general public regarding RF exposures. This paper is a compilation of the conclusions, on the biological effects of RF exposures, from various national and international expert groups, based on their analyses. In general, the expert groups suggested a reduction in exposure levels, precautionary approach, and further research. PMID:25211777

  14. International and National Expert Group Evaluations: Biological/Health Effects of Radiofrequency Fields

    PubMed Central

    Vijayalaxmi; Scarfi, Maria R.

    2014-01-01

    The escalated use of various wireless communication devices, which emit non-ionizing radiofrequency (RF) fields, have raised concerns among the general public regarding the potential adverse effects on human health. During the last six decades, researchers have used different parameters to investigate the effects of in vitro and in vivo exposures of animals and humans or their cells to RF fields. Data reported in peer-reviewed scientific publications were contradictory: some indicated effects while others did not. International organizations have considered all of these data as well as the observations reported in human epidemiological investigations to set-up the guidelines or standards (based on the quality of published studies and the “weight of scientific evidence” approach) for RF exposures in occupationally exposed individuals and the general public. Scientists with relevant expertise in various countries have also considered the published data to provide the required scientific information for policy-makers to develop and disseminate authoritative health information to the general public regarding RF exposures. This paper is a compilation of the conclusions, on the biological effects of RF exposures, from various national and international expert groups, based on their analyses. In general, the expert groups suggested a reduction in exposure levels, precautionary approach, and further research. PMID:25211777

  15. NASA plan for international crustal dynamics studies

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The international activities being planned as part of the NASA geodynamics program are described. Methods of studying the Earth's crustal movements and deformation characteristics are discussed. The significance of the eventual formalations of earthquake predictions methods is also discussed.

  16. Hanford single-shell tank grouping study

    SciTech Connect

    Remund, K.M.; Anderson, C.M.; Simpson, B.C.

    1995-10-01

    A tank grouping study has been conducted to find Hanford single-shell tanks with similar waste properties. The limited sampling resources of the characterization program could be allocated more effectively by having a better understanding of the groups of tanks that have similar waste types. If meaningful groups of tanks can be identified, tank sampling requirements may be reduced, and the uncertainty of the characterization estimates may be narrowed. This tank grouping study considers the analytical sampling information and the historical information that is available for all single-shell tanks. The two primary sources of historical characterization estimates and information come from the Historical Tank Content Estimate (HTCE) Model and the Sort on Radioactive Waste Tanks (SORWT) Model. The sampling and historical information are used together to come up with meaningful groups of similar tanks. Based on the results of analyses presented in this report, credible tank grouping looks very promising. Some groups defined using historical information (HTCE and SORWT) correspond well with those based on analytical data alone.

  17. Space Station concept development group studies

    NASA Technical Reports Server (NTRS)

    Powell, L. E.

    1984-01-01

    The NASA study activities in preparation for a Space Station began in the early 1970's. The early studies included many in-house NASA and contracted studies. A group of representatives from all the NASA Centers, titled the Space Station Concept Development Group (CDG) was involved in the studies which led to the initiation of the Space Station Program. The CDG studies were performed over a period of approximately one year and consisted of four phases. The initial phase had the objective to determine the functions required of the station as opposed to a configuration. The activities of the second phase were primarily concerned with a sizing of the facilities required for payloads and the resources necessary to support these mission payloads. The third phase of studies was designed to develop a philosophical approach to a number of areas related to autonomy, maintainability, operations and logistics, and verification. The fourth phase of the study was to be concerned with configuration assessment activities.

  18. Conformational relaxation and water penetration coupled to ionization of internal groups in proteins

    PubMed Central

    Damjanović, Ana; Brooks, Bernard R.; Bertrand García-Moreno, E

    2012-01-01

    Molecular dynamics simulations were used to examine the effects of ionization of internal groups on the structures of eighteen variants of staphylococcal nuclease (SNase) with internal Lys, Asp, or Glu. In most cases the RMSD values of internal ionizable side chains were larger when the ionizable moieties were charged than when they were neutral. Calculations of solvent-accessible surface area showed that the internal ionizable side chains were buried in the protein interior when they were neutral, and moved towards crevices and the protein-water interface when they were charged. The only exceptions are Lys-36, Lys-62, Lys-92 and Lys-103, which remained buried even after charging. With the exception of Lys-38, the number of internal water molecules surrounding the ionizable group increased upon charging: the average number of water oxygen atoms within the first hydration shell increased by 1.7 for Lys residues, by 5.2 for Asp residues, and by 3.2 for Glu residues. The polarity of the micro environment of the ionizable group also increased when the groups were charged: the average number of polar atoms of any kind within the first hydration shell increased by 2.7 for Lys residues, by 4.8 for Asp residues, and by 4.0 for Glu residues. An unexpected linear relationship was observed between the absolute value of the shifts in pKa values measured experimentally, and structural relaxation as described in terms of the net difference in the polarity of the micro environment of the charged and neutral forms of the ionizable groups, and of the RMSD values of the charged side chains. The effects of ionization of internal groups on the conformation of the backbone were noticeable but mostly small and localized to the area immediately next to the internal ionizable moiety. Some variants did exhibit local unfolding. PMID:21428436

  19. Spectroscopic investigation of the vibrational quasi-continuum arising from internal rotation of a methyl group. Final report, 1990 - 1993

    SciTech Connect

    Hougen, J.T.

    1993-12-31

    Spectroscopy was used to study the vibrational quasi-continuum arising from internal rotation of the methyl group in acetaldehyde. We now understand the torsion-rotation levels from all 3 torsional states below the top of the torsional barrier. Investigations of four ordinary vibrational states in acetaldehyde are in progress.

  20. Effectiveness of Group Activity Play Therapy on Internalizing and Externalizing Behavior Problems of Preadolescent Orphans in Uganda

    ERIC Educational Resources Information Center

    Ojiambo, Deborah

    2011-01-01

    This pilot study investigated the impact of group activity play therapy (GAPT) on displaced orphans aged 10 to 12 years living in a large children's village in Uganda. Teachers and housemothers identified 60 preadolescents exhibiting clinical levels of internalizing and externalizing behavior problems. The participants' ethnicity was…

  1. Rationale and design of the HepZero study: a prospective, multicenter, international, open, randomized, controlled clinical study with parallel groups comparing heparin-free dialysis with heparin-coated dialysis membrane (Evodial) versus standard care: study protocol for a randomized controlled trial

    PubMed Central

    2013-01-01

    Background Anticoagulation for chronic dialysis patients with contraindications to heparin administration is challenging. Current guidelines state that in patients with increased bleeding risks, strategies that can induce systemic anticoagulation should be avoided. Heparin-free dialysis using intermittent saline flushes is widely adopted as the method of choice for patients at risk of bleeding, although on-line blood predilution may also be used. A new dialyzer, Evodial (Gambro, Lund, Sweden), is grafted with unfractionated heparin during the manufacturing process and may allow safe and efficient heparin-free hemodialysis sessions. In the present trial, Evodial was compared to standard care with either saline flushes or blood predilution. Methods The HepZero study is the first international (seven countries), multicenter (10 centers), randomized, controlled, open-label, non-inferiority (and if applicable subsequently, superiority) trial with two parallel groups, comprising 252 end-stage renal disease patients treated by maintenance hemodialysis for at least 3 months and requiring heparin-free dialysis treatments. Patients will be treated during a maximum of three heparin-free dialysis treatments with either saline flushes or blood predilution (control group), or Evodial. The first heparin-free dialysis treatment will be considered successful when there is: no complete occlusion of air traps or dialyzer rendering dialysis impossible; no additional saline flushes to prevent clotting; no change of dialyzer or blood lines because of clotting; and no premature termination (early rinse-back) because of clotting. The primary objectives of the study are to determine the effectiveness of the Evodial dialyzer, compared with standard care in terms of successful treatments during the first heparin-free dialysis. If the non-inferiority of Evodial is demonstrated then the superiority of Evodial over standard care will be tested. The HepZero study results may have major clinical

  2. Report of the Public Cryptography Study Group.

    ERIC Educational Resources Information Center

    American Council on Education, Washington, DC.

    Concerns of the National Security Agency (NSA) that information contained in some articles about cryptography in learned and professional journals and in monographs might be inimical to the national security are addressed. The Public Cryptography Study Group, with one dissenting opinion, recommends that a voluntary system of prior review of…

  3. Metacognition and Group Differences: A Comparative Study

    ERIC Educational Resources Information Center

    Al-Hilawani, Yasser A.

    2014-01-01

    In this study, metacognition refers to performing visual analysis and discrimination of real life events and situations in naïve psychology, naïve physics, and naïve biology domains. It is used, along with measuring reaction time, to examine differences in the ability of four groups of students to select appropriate pictures that correspond with…

  4. Subcutaneous recombinant hirudin (HBW 023) versus intravenous sodium heparin in treatment of established acute deep vein thrombosis of the legs: a multicentre prospective dose-ranging randomized trial. International Multicentre Hirudin Study Group.

    PubMed

    Schiele, F; Lindgaerde, F; Eriksson, H; Bassand, J P; Wallmark, A; Hansson, P O; Grollier, G; Sjo, M; Moia, M; Camez, A; Smyth, V; Walker, M

    1997-05-01

    The aim of this multicentre, prospective, randomised, dose-ranging study was to compare the safety and efficacy of subcutaneous recombinant hirudin (HBW 023) against intravenous sodium heparin in acute lower limb deep venous thrombosis (DVT). Patients were randomized to treatment with either HBW 023 or heparin for 5 +/- 1 days. HBW 023 was given according to body-weight in three dose groups. Thromboembolic disease was assessed by phlebography and ventilation/perfusion (V/Q) scanning on Day 1 and Day 5 +/- 1. One hundred and fifty-five patients were enrolled, of these 121 were evaluable for efficacy analysis. Significantly fewer patients on HBW 023 developed new V/Q abnormalities during the treatment period, (p = 0.006). There was no difference between the groups in thrombus extension or regression, major bleeding complications or serious adverse events. There were significantly fewer findings of new V/Q mismatch after treatment with HBW 023, and anticoagulant control was superior in these patients. PMID:9184388

  5. How good are the internal controls in your group practice? Ten questions to contemplate.

    PubMed

    Grant, Barbara J; Foley, Lori A

    2002-01-01

    Internal controls are the methods and procedures used by any business to prevent or detect errors, safeguard assets (especially cash) from being misappropriated, and encourage staff adherence to prescribed managerial policies. Internal controls in a medical practice differ depending on the size and complexity of the practice. The key, however, is that they prevent or detect errors and efforts to circumvent the established policies and procedures of the organization. How good are the internal controls in your group practice? This article identifies ten questions you should use to evaluate your risk of asset misappropriation. PMID:12122813

  6. Space station group activities habitability module study

    NASA Technical Reports Server (NTRS)

    Nixon, David

    1986-01-01

    This study explores and analyzes architectural design approaches for the interior of the Space Station Habitability Module (originally defined as Habitability Module 1 in Space Station Reference Configuration Decription, JSC-19989, August 1984). In the Research Phase, architectural program and habitability design guidelines are specified. In the Schematic Design Phase, a range of alternative concepts is described and illustrated with drawings, scale-model photographs and design analysis evaluations. Recommendations are presented on the internal architectural, configuration of the Space Station Habitability Module for such functions as the wardroom, galley, exercise facility, library and station control work station. The models show full design configurations for on-orbit performance.

  7. Determination of HDV ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics

    PubMed Central

    Kellerman, Daniel L; Simmons, Kandice S; Pedraza, Mayra; Piccirilli, Joseph A; York, Darrin M; Harris, Michael E

    2015-01-01

    Biological catalysis involves interactions distant from the site of chemistry that can position the substrate for reaction. Catalysis of RNA 2′-O-transphosphorylation by the HDV ribozyme is sensitive to the identity of the N(-1) nucleotide flanking the reactive phosphoryl group. However, the interactions that affect the conformation of this position, and in turn the 2′O nucleophile, are unclear. Here, we describe the application of multiple substrate internal competition kinetic analyses to understand how the N(-1) nucleobase contributes to HDV catalysis, and to test the utility of this approach for RNA structure-function studies. Internal competition reactions containing all four substrate sequence variants at the N(-1) position in reactions using ribozyme active site mutations at A77 and A78 were used to test a proposed basepairing interaction. Mutants A78U, A78G and A79G retain significant catalytic activity, but do not alter the specificity for the N(-1) nucleobase. Effects of nucleobase analog substitutions at N(-1) indicate that U is preferred due to the ability to donate an H-bond in the Watson-Crick face and avoid minor groove steric clash. The results provide information essential for evaluating models of the HDV active site, and illustrate multiple-substrate kinetic analyses as a practical approach for characterizing structure-function relationships in RNA reactions. PMID:25937290

  8. THE COOPERATIVE INTERNATIONAL NEUROMUSCULAR RESEARCH GROUP DUCHENNE NATURAL HISTORY STUDY: GLUCOCORTICOID TREATMENT PRESERVES CLINICALLY MEANINGFUL FUNCTIONAL MILESTONES AND REDUCES RATE OF DISEASE PROGRESSION AS MEASURED BY MANUAL MUSCLE TESTING AND OTHER COMMONLY USED CLINICAL TRIAL OUTCOME MEASURES

    PubMed Central

    HENRICSON, ERIK K.; ABRESCH, R. TED; CNAAN, AVITAL; HU, FENGMING; DUONG, TINA; ARRIETA, ADRIENNE; HAN, JAY; ESCOLAR, DIANA M.; FLORENCE, JULAINE M.; CLEMENS, PAULA R.; HOFFMAN, ERIC P.; McDONALD, CRAIG M.

    2014-01-01

    Introduction Glucocorticoid (GC) therapy in Duchenne muscular dystrophy (DMD) has altered disease progression, necessitating contemporary natural history studies. Methods The Cooperative Neuromuscular Research Group (CINRG) DMD Natural History Study (DMD-NHS) enrolled 340 DMD males, ages 2–28 years. A comprehensive battery of measures was obtained. Results A novel composite functional “milestone” scale scale showed clinically meaningful mobility and upper limb abilities were significantly preserved in GC-treated adolescents/young adults. Manual muscle test (MMT)-based calculations of global strength showed that those patients <10 years of age treated with steroids declined by 0.4±0.39 MMT unit/year, compared with −0.4±0.39 MMT unit/year in historical steroid-naive subjects. Pulmonary function tests (PFTs) were relatively preserved in steroid-treated adolescents. The linearity and magnitude of decline in measures were affected by maturational changes and functional status. Conclusions In DMD, long-term use of GCs showed reduced strength loss and preserved functional capabilities and PFTs compared with previous natural history studies performed prior to the widespread use of GC therapy. PMID:23649481

  9. Integrated Assessments and Policy Evaluation group and Center for International Energy Development. Program summary

    SciTech Connect

    Not Available

    1985-04-01

    This report summarizes programmatic accomplishments since 1981 in two staff groups of the Energy and Environmental Systems Division: the Integrated Assessments and Policy Evaluation (IAPE) group and the Center for International Energy Development (CIED). This summary, presented in Sections 2-4, provides background information on major accomplishments. The introduction presents an overview of staffing and programs, and Section 5 lists recent publications. 38 figs., 13 tabs.

  10. Simulated Group Counseling for Group Work Training: A Four-Year Research Study of Group Development.

    ERIC Educational Resources Information Center

    Romano, John L.; Sullivan, Brandon A.

    2000-01-01

    Examines Simulated Group Counseling (SGC), a training model for graduate-level group workers. During a four-year period, 98 graduate students participated in 12 role-played SGC groups. SGC followed a model of group development and was highly consistent with expected changes in non-role-played groups. Discusses SGC advantages, especially related to…

  11. Cretaceous Cogollo Group study - District Zulia Occidental

    SciTech Connect

    Lagazzi, R.; D`Antonio, G.; Hung, O.; Avila, A.

    1996-08-01

    The Cretaceous Cogollo Group, with over 1500 feet of platform carbonate and shale section, contains important oil accumulations in the west portion of the Maracaibo basin. However, after discovery of the major oil fields, all subsequent exploration and exploitation efforts led to disappointing results. This paper summarizes the study of the Cogollo Group in the Lake Maracaibo West Coast area, where light Cretaceous oil may have an impact on the total reserves. After integrating the Cogollo Group into the regional framework, the study focuses on the District Zulia Occidental, where over 40 deep wells either penetrated or tested the reservoir. Structural and stratigraphic descriptions are enriched by a significant amount of core and petrophysical data that leads to a better understanding of the reservoir layering and pore geometry. Well production performance and reservoir data are incorporated to the study as additional tools to determine the size of the oil accumulations. Finally, the study addresses the possibility of drilling slant or horizontal wells as a way to reduce the number of dry holes or marginal producers.

  12. Canadian Mathematics Education Study Group = Groupe Canadien d'etude en didactique des mathematiques. Proceedings of the 1994 Annual Meeting (Regina, Saskatchewan, Canada, June 3-7, 1994).

    ERIC Educational Resources Information Center

    Quigley, Martyn, Ed.

    These proceedings contain papers from the 1994 annual meeting of the Canadian Mathematics Education Study Group. Papers are divided into the following sections: (1) invited lectures; (2) working groups; (3) topic groups; (4) ad hoc groups; and (5) reports on ICMI (International Committee on Mathematical Instruction) studies. Papers include: (1)…

  13. The Second International Piping Integrity Research Group (IPIRG-2) program. Final report, October 1991--April 1996

    SciTech Connect

    Hopper, A.; Wilowski, G.; Scott, P.; Olson, R.

    1997-03-01

    The IPIRG-2 program was an international group program managed by the US NRC and funded by organizations from 15 nations. The emphasis of the IPIRG-2 program was the development of data to verify fracture analyses for cracked pipes and fittings subjected to dynamic/cyclic load histories typical of seismic events. The scope included: (1) the study of more complex dynamic/cyclic load histories, i.e., multi-frequency, variable amplitude, simulated seismic excitations, than those considered in the IPIRG-1 program, (2) crack sizes more typical of those considered in Leak-Before-Break (LBB) and in-service flaw evaluations, (3) through-wall-cracked pipe experiments which can be used to validate LBB-type fracture analyses, (4) cracks in and around pipe fittings, such as elbows, and (5) laboratory specimen and separate effect pipe experiments to provide better insight into the effects of dynamic and cyclic load histories. Also undertaken were an uncertainty analysis to identify the issues most important for LBB or in-service flaw evaluations, updating computer codes and databases, the development and conduct of a series of round-robin analyses, and analyst`s group meetings to provide a forum for nuclear piping experts from around the world to exchange information on the subject of pipe fracture technology. 17 refs., 104 figs., 41 tabs.

  14. The International Research Training Group (GRK532): Practicing Cross-Border Postgraduate Education

    ERIC Educational Resources Information Center

    Ehses, Markus; Veith, Michael

    2009-01-01

    In 1999, the International Research Training Group "GRK532" was founded as a pilot project for cross-border European postgraduate education along the German/French/Luxembourg borders. The project consists of an interdisciplinary research programme on synthesis, isolation and characterization of new materials accompanied by an ambitious continuous…

  15. Development and Implementation of an International Counseling Outreach Effort in Bhutan: A Group Stage Conceptualization

    ERIC Educational Resources Information Center

    Guth, Lorraine J.; Lorelle, Sonya; Hinkle, J. Scott; Remley, Theodore P.

    2015-01-01

    This article highlights the development and implementation of an international counseling outreach program in Bhutan using a group stage conceptualization that includes the initial, transition, working, and final stages. The initial stage included a counseling initiative started by one of the queens as well as meetings with key leaders from the…

  16. 75 FR 59049 - International Education Programs Service; Fulbright-Hays Group Projects Abroad Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ...The Assistant Secretary for Postsecondary Education announces two priorities for the Fulbright-Hays Group Projects Abroad (GPA) Program administered by the International Education Programs Service. The Assistant Secretary may use these priorities for competitions in fiscal year (FY) 2011 and later years. We intend these two priorities to help increase the number of teachers at the......

  17. 76 FR 5832 - International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA, San Jose, CA; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated...

  18. Supporting the Thesis Writing Process of International Research Students through an Ongoing Writing Group

    ERIC Educational Resources Information Center

    Li, Linda Y.; Vandermensbrugghe, Joelle

    2011-01-01

    Evidence from research suggests writing support is particularly needed for international research students who have to tackle the challenges of thesis writing in English as their second language in Western academic settings. This article reports the development of an ongoing writing group to support the thesis writing process of international…

  19. Absence of synergy for monosynaptic Group I inputs between abdominal and internal intercostal motoneurons

    PubMed Central

    Ford, T. W.; Meehan, C. F.

    2014-01-01

    Internal intercostal and abdominal motoneurons are strongly coactivated during expiration. We investigated whether that synergy was paralleled by synergistic Group I reflex excitation. Intracellular recordings were made from motoneurons of the internal intercostal nerve of T8 in anesthetized cats, and the specificity of the monosynaptic connections from afferents in each of the two main branches of this nerve was investigated. Motoneurons were shown by antidromic excitation to innervate three muscle groups: external abdominal oblique [EO; innervated by the lateral branch (Lat)], the region of the internal intercostal muscle proximal to the branch point (IIm), and muscles innervated from the distal remainder (Dist). Strong specificity was observed, only 2 of 54 motoneurons showing excitatory postsynaptic potentials (EPSPs) from both Lat and Dist. No EO motoneurons showed an EPSP from Dist, and no IIm motoneurons showed one from Lat. Expiratory Dist motoneurons fell into two groups. Those with Dist EPSPs and none from Lat (group A) were assumed to innervate distal internal intercostal muscle. Those with Lat EPSPs (group B) were assumed to innervate abdominal muscle (transversus abdominis or rectus abdominis). Inspiratory Dist motoneurons (assumed to innervate interchondral muscle) showed Dist EPSPs. Stimulation of dorsal ramus nerves gave EPSPs in 12 instances, 9 being in group B Dist motoneurons. The complete absence of heteronymous monosynaptic Group I reflex excitation between muscles that are synergistically activated in expiration leads us to conclude that such connections from muscle spindle afferents of the thoracic nerves have little role in controlling expiratory movements but, where present, support other motor acts. PMID:24920027

  20. Families and Family Study in International Perspective

    ERIC Educational Resources Information Center

    Adams, Bert N.

    2004-01-01

    Many changes are occurring in the world's families. Some observers feel that the changes are destructive, whereas others see them as leading to new opportunities and understanding. Issues in international family studies include regional limitations and the various aspects of doing research cross-culturally. Knowledge regarding certain categories…

  1. Undergraduate International Studies and Foreign Language Program

    ERIC Educational Resources Information Center

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    The Undergraduate International Studies and Foreign Language Program provides funds to institutions of higher education, a consortia of such institutions, or partnerships between nonprofit organizations and institutions of higher education to plan, develop, and implement programs that strengthen and improve undergraduate instruction in…

  2. Factorial and Item-Level Invariance of an Emotional Intelligence Scale across Groups of International Students

    ERIC Educational Resources Information Center

    Wang, Chuang; Kim, Do-Hong; Ng, Kok-Mun

    2012-01-01

    This study examined the factorial and item-level invariance of Wong and Law's emotional intelligence scale (WLEIS) in a sample of 375 international students in U.S. universities. Confirmatory factor analysis (CFA) and differential item functioning (DIF) analysis were employed at the test and item level, respectively. International students from…

  3. Internal Consistency and Power When Comparing Total Scores from Two Groups.

    PubMed

    Barchard, Kimberly A; Brouwers, Vincent

    2016-01-01

    Researchers now know that when theoretical reliability increases, power can increase, decrease, or stay the same. However, no analytic research has examined the relationship of power to the most commonly used type of reliability-internal consistency-and the most commonly used measures of internal consistency, coefficient alpha and ICC(A,k). We examine the relationship between the power of independent samples t tests and internal consistency. We explicate the mathematical model upon which researchers usually calculate internal consistency, one in which total scores are calculated as the sum of observed scores on K measures. Using this model, we derive a new formula for effect size to show that power and internal consistency are influenced by many of the same parameters but not always in the same direction. Changing an experiment in one way (e.g., lengthening the measure) is likely to influence multiple parameters simultaneously; thus, there are no simple relationships between such changes and internal consistency or power. If researchers revise measures to increase internal consistency, this might not increase power. To increase power, researchers should increase sample size, select measures that assess areas where group differences are largest, and use more powerful statistical procedures (e.g., ANCOVA). PMID:27269041

  4. Women's Participation in Physics Internationally: the IUPAP Working Group on Women

    NASA Astrophysics Data System (ADS)

    Franz, Judy

    2001-04-01

    In 1999 the General Assembly of the International Union of Pure and Applied Physics (IUPAP) voted to establish a Working Group on Women in Physics with the following charge: to survey the situation for women in physics in IUPAP member countries; to analyze and report the data collected along with suggestions on how to improve the situation; to suggest ways that women can become more involved in IUPAP, including the Liaison Committees, the Commissions, the Council, and the General Assemblies; and to report all findings at the next General Assembly in 2002. The Working Group was established in 2000 with 11 members representing North and South America, Europe, Asia and the Middle East/Africa. The Group has been gathering data on women in physics and is planning to hold an International Conference on Women in Physics at UNESCO Headquarters in Paris in March, 2002. I will discuss some of the findings and the plans for the future.

  5. 78 FR 53194 - Advisory Group to the Internal Revenue Service Tax Exempt and Government Entities Division (TE/GE...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... Internal Revenue Service Advisory Group to the Internal Revenue Service Tax Exempt and Government Entities Division (TE/GE); Meeting AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice. SUMMARY: The... a.m. to 11:30 a.m., at the Internal Revenue Service; 1111 Constitution Ave. NW.; Room...

  6. Group exposure for agoraphobics: a replication study.

    PubMed

    Teasdale, J D; Walsh, P A; Lancashire, M; Mathews, A M

    1977-02-01

    A replication study was conducted of the treatment of agoraphobics by exposure in cohesive groups, as described by Hand, Lamantagne and Marks (1974). The continuing improvement during follow-up, with consequent large overall improvement, reported in the original study was not replicated. However, the present study confirmed the usefulness of this procedure as a highly cost-efficient treatment. The assumed equivalence of the Gelder and Marks (1966) phobic rating scale and its modification by Watson and Marks (1971) was examined. Large discrepancies between the scales were obtained for initial assessments and change scores. It is suggested that there is a need for workers in this field to agree on methods of measurement. PMID:837039

  7. The Effect of Student Participation in International Study.

    ERIC Educational Resources Information Center

    DeDee, Lynda S.; Stewart, Stephanie

    2003-01-01

    Responses were received from 38 of 100 nursing graduates who completed a 2-week international study tour. International study had a significant impact on personal development, the nurse's role, international perspective, and intellectual development. (SK)

  8. Brief report: Peer group influences and adolescent internalizing problems as mediated by effortful control.

    PubMed

    Dyson, Rachel; Robertson, Gail C; Wong, Maria M

    2015-06-01

    Internalizing problems in adolescence encompass behaviors directed inward at the self (Colman, Wadsworth, Croudace, & Jones, 2007). Several predictors have been linked to internalizing problems including antisocial and prosocial peers (Cartwright, 2007; Chung, 2010). Effortful control, a component of self-regulation, is one factor that could mediate the relationship between peer behaviors and individual outcomes. This study assessed the relationship between peer behaviors, effortful control, and adolescent internalizing problems. Participants were 151 middle school adolescents (M = 12.16 years old) who completed self-report questionnaires regarding behaviors of their peers, perceptions of effortful control, and experiences of internalizing problems. Structural equation modeling (SEM) yielded a significant negative relationship between antisocial peers and effortful control, and a significant positive relationship between prosocial peers and effortful control. In addition, effortful control significantly mediated the relationship between prosocial peers and internalizing problems, but not for antisocial peers. Implications for interventions related to adolescent health were discussed. PMID:25863002

  9. Assessment of Proficiency in Japanese as a Foreign Language. Conference Proceedings of an International Working Group Sponsored by the Asian Studies Council (Canberra, Australia, June 12-14, 1990).

    ERIC Educational Resources Information Center

    Wylie, Elaine, Ed.

    The proceedings of a working group conference on proficiency testing of Japanese as a second language contain a brief background paper distributed to conference invitees, a list of items included in the pre-conference portfolio, an advance organizer of potential discussion topics, a 77-item annotated list of bibliographies on second language…

  10. Environmental studies group. Annual report for 1978

    SciTech Connect

    Hunt, D. C.; Hurley, J. D.

    1980-08-21

    Group projects included radioecological studies of aquatic and terrestrial systems, land management activities, foodstuff monitoring, dust transport studies including fugitive dust measurements and modeling, and several support programs involving evaluation of the plant's ambient air samplers and airborne tritium monitoring techniques. Some salient results from the several project reports include determination of an appropriate model for mechanically generated fugitive dust dispersion, a radionuclide inventory of Smart Ditch Pond (Pond D-1), a coefficient of community determination for two terrestrial sample plots on the plant site buffer zone, a natality and mortality rate determination for fawns in the plant deer herd (including one positive coyote-kill determination), inlet loss and filter paper collection efficiencies for the plant ambient air samplers, and differential tritium sampling measurements of the vapor in Building 771 stack effluent.

  11. Multicultural Influences on Group Learning: A Qualitative Higher Education Study

    ERIC Educational Resources Information Center

    Sweeney, Arthur; Weaven, Scott; Herington, Carmel

    2008-01-01

    Although the literature examining the usefulness of group projects is extensive, the link between cooperative learning, group performance and skills transfer in multicultural contexts remains unclear. Focus groups were conducted with a sample of 107 international and domestic postgraduate and undergraduate marketing students to investigate this…

  12. Cross-year peer tutoring on internal medicine wards: results of a qualitative focus group analysis

    PubMed Central

    Krautter, Markus; Andreesen, Sven; Köhl-Hackert, Nadja; Hoffmann, Katja; Herzog, Wolfgang; Nikendei, Christoph

    2014-01-01

    Background Peer-assisted learning (PAL) has become a well-accepted teaching method within medical education. However, descriptions of on-ward PAL programs are rare. A focus group analysis of a newly established PAL program on an internal medicine ward was conducted to provide insights into PAL teaching from a student perspective. Purpose To provide insights into students’ experiences regarding their on-ward training with and without accompanying PAL tutors. Methods A total of N=168 medical students in their sixth semester participated in the investigation (intervention group: N=88; control group: N=80). The intervention group took part in the PAL program, while the control group received standard on-ward training. There were seven focus groups with N=43 participants (intervention group: four focus groups, N=28 participants; control group: three focus groups, N=15 participants). The discussions were analyzed using content analysis. Results The intervention group emphasized the role of the tutors as competent and well-trained teachers, most beneficial in supervising clinical skills. Tutors motivate students, help them to integrate into the ward team, and provide a non-fear-based working relationship whereby students’ anxiety regarding working on ward decreases. The control group had to rely on autodidactic learning strategies when neither supervising physicians nor final-year students were available. Conclusion On-ward PAL programs represent a particularly valuable tool for students’ support in training clinical competencies on ward. The tutor–student working alliance acts through its flat hierarchy. Nevertheless, tutors cannot represent an adequate substitute for experienced physicians. PMID:25278789

  13. The International Dermatology Outcome Measures Group: formation of patient-centered outcome measures in dermatology.

    PubMed

    Gottlieb, Alice B; Levin, Adriane A; Armstrong, April W; Abernethy, April; Duffin, Kristina Callis; Bhushan, Reva; Garg, Amit; Merola, Joseph F; Maccarone, Mara; Christensen, Robin

    2015-02-01

    As quality standards are increasingly in demand throughout medicine, dermatology needs to establish outcome measures to quantify the effectiveness of treatments and providers. The International Dermatology Outcome Measures Group was established to address this need. Beginning with psoriasis, the group aims to create a tool considerate of patients and providers using the input of all relevant stakeholders in assessment of disease severity and response to treatment. Herein, we delineate the procedures through which consensus is being reached and the future directions of the project. PMID:25486914

  14. International geomagnetic reference field 1980: a report by IAGA Division I working group.

    USGS Publications Warehouse

    Peddie, N.W.

    1982-01-01

    Describes the recommendations of the working group, which suggested additions to IGRF because of the cumulative effect of the inevitable uncertainties in the secular variation models which had led to unacceptable inaccuracies in the IGRF by the late 1970's. The recommendations were accepted by the International Association of Geomagnetism and Aeronomy on August 15, 1981 at the 4th Scientific Assembly, Edinburgh. An extended table sets out spherical harmonic coefficients of the IGRF 1980.-R.House

  15. Bayesian Model Selection for Group Studies

    PubMed Central

    Stephan, Klaas Enno; Penny, Will D.; Daunizeau, Jean; Moran, Rosalyn J.; Friston, Karl J.

    2009-01-01

    approaches in the presence of outliers. We expect that this new random effects method will prove useful for a wide range of group studies, not only in the context of DCM, but also for other modelling endeavours, e.g. comparing different source reconstruction methods for EEG/MEG or selecting among competing computational models of learning and decision-making. PMID:19306932

  16. Imaging in pleural mesothelioma: A review of the 12th International Conference of the International Mesothelioma Interest Group.

    PubMed

    Armato, Samuel G; Coolen, Johan; Nowak, Anna K; Robinson, Cleo; Gill, Ritu R; Straus, Christopher; Khanwalkar, Ashoke

    2015-11-01

    Imaging of malignant pleural mesothelioma is essential to patient management, prognostication, and response assessment. From animal models to clinical trials, the gamut of research activities and clinical standards relies on imaging to provide information on lesion morphology and the growing number of physiologic characteristics amenable to capture through imaging techniques. The complex morphology, growth pattern, and biological mechanisms of mesothelioma, however, present challenges for image acquisition and interpretation. Nevertheless, novel approaches to image acquisition and subsequent image analysis have expanded the opportunities for (as well as the need for) imaging in this disease. This paper summarizes the imaging-based research presented orally at the 2014 International Conference of the International Mesothelioma Interest Group (iMig) in Cape Town, South Africa, October 2014. Presented topics include the imaging of hypoxia in a murine model through positron emission tomography (PET), the use of diffusion-weighted magnetic resonance imaging (MRI) to assess the histologic composition of biphasic mesothelioma and to assess early response to chemotherapy, the correlation of CT-based tumor volume with the volume of the post-surgical tumor specimen, the development of volumetric tumor response criteria, and pre-treatment tumor volume growth considerations for tumor response assessment. PMID:26298162

  17. International Space Station Air Quality Assessed According to Toxicologically-Grouped Compounds

    NASA Technical Reports Server (NTRS)

    James, John T.; Limero, Tom; DeVera, Vanessa; Cheng, Patti; Hand, Jennifer; Macatangay, Ariel; Beck, Steve

    2009-01-01

    Scores of compounds are found in the International Space Station (ISS) atmospheric samples that are returned to the Johnson Space Center Toxicology Laboratory for analysis. Spacecraft Maximum Allowable Concentrations (SMACs) are set with the view that each compound is present as if there were no other compounds present. In order to apply SMACs to the interpretation of the analytical data, the toxicologist must employ some method of combining the potential effects of the aggregate of compounds found in the atmospheric samples. The simplest approach is to assume that each quantifiable compound has the potential for some effect in proportion to the applicable SMAC, and then add all the proportions. This simple paradigm disregards the fact that most compounds have potential to adversely affect only a few physiological systems, and their effects would be independent rather than additive. An improved approach to dealing with exposure to mixtures is to add the proportions only for compounds that adversely affect the same physiological system. For example, toxicants that cause respiratory irritation are separated from those that cause neurotoxicity or cardio-toxicity. Herein we analyze ISS air quality data according to toxicological groups with a view that this could be used for understanding any crew symptoms occurring at the time of the sample. In addition, this approach could be useful in post-flight longitudinal surveys where the flight surgeon may need to identify post-flight, follow-up medical studies because of on-orbit exposures that target specific physiological systems.

  18. International Space Station Air Quality Assessed According to Toxicologically-Grouped Compounds

    NASA Technical Reports Server (NTRS)

    James, John T.; Limero, Thomas F.; Beck, Steve; Cheng, Patti F.; deVera, Vanessa J.; Hand, Jennifer; Macatangay, Ariel

    2010-01-01

    Scores of compounds are found in the International Space Station (ISS) atmospheric samples that are returned to the Johnson Space Center Toxicology Laboratory for analysis. Spacecraft Maximum Allowable Concentrations (SMACs) are set with the view that each compound is present as if there were no other compounds present. In order to apply SMACs to the interpretation of the analytical data, the toxicologist must employ some method of combining the potential effects of the aggregate of compounds found in the atmospheric samples. The simplest approach is to assume that each quantifiable compound has the potential for some effect in proportion to the applicable SMAC, and then add all the proportions. This simple paradigm disregards the fact that most compounds have potential to adversely affect only a few physiological systems, and their effects would be independent rather than additive. An improved approach to dealing with exposure to mixtures is to add the proportions only for compounds that adversely affect the same physiological system. For example, toxicants that cause respiratory irritation are separated from those that cause neurotoxicity or cardio-toxicity. Herein we analyze ISS air quality data according to toxicological groups with a view that this could be used for understanding any crew symptoms occurring at the time of the sample acquisition. In addition, this approach could be useful in post-flight longitudinal surveys where the flight surgeon may need to identify post-flight, follow-up medical studies because of on-orbit exposures that target specific physiological systems.

  19. Definition of a COPD self-management intervention: International Expert Group consensus.

    PubMed

    Effing, Tanja W; Vercoulen, Jan H; Bourbeau, Jean; Trappenburg, Jaap; Lenferink, Anke; Cafarella, Paul; Coultas, David; Meek, Paula; van der Valk, Paul; Bischoff, Erik W M A; Bucknall, Christine; Dewan, Naresh A; Early, Frances; Fan, Vincent; Frith, Peter; Janssen, Daisy J A; Mitchell, Katy; Morgan, Mike; Nici, Linda; Patel, Irem; Walters, Haydn; Rice, Kathryn L; Singh, Sally; Zuwallack, Richard; Benzo, Roberto; Goldstein, Roger; Partridge, Martyn R; van der Palen, Job

    2016-07-01

    There is an urgent need for consensus on what defines a chronic obstructive pulmonary disease (COPD) self-management intervention. We aimed to obtain consensus regarding the conceptual definition of a COPD self-management intervention by engaging an international panel of COPD self-management experts using Delphi technique features and an additional group meeting.In each consensus round the experts were asked to provide feedback on the proposed definition and to score their level of agreement (1=totally disagree; 5=totally agree). The information provided was used to modify the definition for the next consensus round. Thematic analysis was used for free text responses and descriptive statistics were used for agreement scores.In total, 28 experts participated. The consensus round response rate varied randomly over the five rounds (ranging from 48% (n=13) to 85% (n=23)), and mean definition agreement scores increased from 3.8 (round 1) to 4.8 (round 5) with an increasing percentage of experts allocating the highest score of 5 (round 1: 14% (n=3); round 5: 83% (n=19)).In this study we reached consensus regarding a conceptual definition of what should be a COPD self-management intervention, clarifying the requisites for such an intervention. Operationalisation of this conceptual definition in the near future will be an essential next step. PMID:27076595

  20. Community Report and Recommendations from International Lunar Exploration Working Group (ILEWG)

    NASA Astrophysics Data System (ADS)

    Foing, Bernard H.

    2016-07-01

    The International Lunar Exploration Working Group (ILEWG) was established in April 1995 at a meeting in Hamburg, Germany. As established in its charter, this working group reports to COSPAR and is charged with developing an international strategy for the exploration of the Moon. It discusses coordination between missions, and a road map for future international lunar exploration and utilisation. It fosters information exchange or potential and real future lunar robotic and human missions, as well as for new scientific and exploration information about the Moon. We refer to COSPAR and ILEWG ICEUM and lunar conferences and declarations [1-18], present the GLUC/ICEUM11 declaration and give a report on ongoing relevant ILEWG community activities. ILEWG supported community forums, ILEWG EuroMoonMars field campaigns and technology validation activities, as well as Young Lunar Explorers events, and activities with broad stakeholders. We discuss how lunar missions SMART-1, Kaguya, Chang'E1&2, Chandrayaan-1, LCROSS, LRO, GRAIL, LADEE, Chang'E3 and upcoming missions contribute to lunar exploration objectives & roadmap towards the Moon Village. GLUC/ICEUM11 declaration: "467 International Lunar Explorers, registered delegates from 26 countries, assembled at GLUC Global Lunar Conference including the 11th ILEWG Conference on Exploration and Utilisation of the Moon (ICEUM11) in Beijing. The conference engaged scientists, engineers, enthusiast explorers, agencies and organisations in the discussion of recent results and activities and the review of plans for exploration. Space agencies representatives gave the latest reports on their current lunar activities and programmes. GLUC-ICEUM11 was a truly historical meeting that demonstrated the world-wide interest in lunar exploration, discovery, and science. More than 400 abstracts were accepted for oral and poster presentations in the technical sessions, organised in 32 sessions within 4 symposia: Science and Exploration; Technology

  1. The effect of deuterium substitution in the amino group on the internal-rotation barrier of acetamide

    NASA Astrophysics Data System (ADS)

    Hirota, Eizi; Kawashima, Yoshiyuki; Usami, Tsuyoshi; Seto, Koichi

    2010-03-01

    Peptide molecules XCO-NYY' are characterized by low potential barrier V3 to internal rotation of a methyl group substituted for X and/or Y. A most conspicuous example is acetamide, for which V3 was previously reported to be 25.043857(19) cm -1[8]. The present study intended to clarify why V3 is so low in acetamide, by examining the effect of the out-of-plane bending or inversion of the amino group on the molecular structure through deuterium substitution for amino hydrogens. The potential barrier V3 in acetamide was found to decrease by 2.630, 2.986, and 5.532 cm -1, when H's at cis, trans, and both positions in the amino group were replaced by deuterium atoms, respectively. The reduction was proportional to the effective mass of the out-of-plane bending mode of the amino group (hereafter referred to as the amino inversion), which was in turn ascribed to the change in electronic resonance character of the peptide linkage. The amino inversion is coupled with the CH 3 internal rotation, producing an interaction term proportional to τ sin 3 α, where τ and α denote the amino inversion and methyl internal rotation angles, respectively. This coupling term, when the inversion is treated by second-order perturbation, yields a V6 term in the internal-rotation potential function of the methyl group, in agreement with the finding of Ilyushin et al. [8], who derived an unusually large V6 term of -10.044874(73) cm -1. It is quite interesting that even a small perturbation such as deuterium substitution causes a substantial change in electronic structure of the peptide linkage.

  2. How Do Internal and External CSR Affect Employees' Organizational Identification? A Perspective from the Group Engagement Model.

    PubMed

    Hameed, Imran; Riaz, Zahid; Arain, Ghulam A; Farooq, Omer

    2016-01-01

    The literature examines the impact of firms' corporate social responsibility (CSR) activities on employees' organizational identification without considering that such activities tend to have different targets. This study explores how perceived external CSR (efforts directed toward external stakeholders) and perceived internal CSR (efforts directed toward employees) activities influence employees' organizational identification. In so doing, it examines the alternative underlying mechanisms through which perceived external and internal CSR activities build employees' identification. Applying the taxonomy prescribed by the group engagement model, the study argues that the effects of perceived external and internal CSR flow through two competing mechanisms: perceived external prestige and perceived internal respect, respectively. Further, it is suggested that calling orientation (how employees see their work contributions) moderates the effects induced by these alternative forms of CSR. The model draws on survey data collected from a sample of 414 employees across five large multinationals in Pakistan. The results obtained using structural equation modeling support these hypotheses, reinforcing the notion that internal and external CSR operate through different mediating mechanisms and more interestingly employees' calling orientation moderates these relationships to a significant degree. Theoretical contributions and practical implications of results are discussed in detail. PMID:27303345

  3. How Do Internal and External CSR Affect Employees' Organizational Identification? A Perspective from the Group Engagement Model

    PubMed Central

    Hameed, Imran; Riaz, Zahid; Arain, Ghulam A.; Farooq, Omer

    2016-01-01

    The literature examines the impact of firms' corporate social responsibility (CSR) activities on employees' organizational identification without considering that such activities tend to have different targets. This study explores how perceived external CSR (efforts directed toward external stakeholders) and perceived internal CSR (efforts directed toward employees) activities influence employees' organizational identification. In so doing, it examines the alternative underlying mechanisms through which perceived external and internal CSR activities build employees' identification. Applying the taxonomy prescribed by the group engagement model, the study argues that the effects of perceived external and internal CSR flow through two competing mechanisms: perceived external prestige and perceived internal respect, respectively. Further, it is suggested that calling orientation (how employees see their work contributions) moderates the effects induced by these alternative forms of CSR. The model draws on survey data collected from a sample of 414 employees across five large multinationals in Pakistan. The results obtained using structural equation modeling support these hypotheses, reinforcing the notion that internal and external CSR operate through different mediating mechanisms and more interestingly employees' calling orientation moderates these relationships to a significant degree. Theoretical contributions and practical implications of results are discussed in detail. PMID:27303345

  4. Computer calculation of the Van Vleck second moment for materials with internal rotation of spin groups

    NASA Astrophysics Data System (ADS)

    Goc, Roman

    2004-09-01

    This paper describes m2rc3, a program that calculates Van Vleck second moments for solids with internal rotation of molecules, ions or their structural parts. Only rotations about C 3 axes of symmetry are allowed, but up to 15 axes of rotation per crystallographic unit cell are permitted. The program is very useful in interpreting NMR measurements in solids. Program summaryTitle of the program: m2rc3 Catalogue number: ADUC Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADUC Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland License provisions: none Computers: Cray SV1, Cray T3E-900, PCs Installation: Poznań Supercomputing and Networking Center ( http://www.man.poznan.pl/pcss/public/main/index.html) and Faculty of Physics, A. Mickiewicz University, Poznań, Poland ( http://www.amu.edu.pl/welcome.html.en) Operating system under which program has been tested: UNICOS ver. 10.0.0.6 on Cray SV1; UNICOS/mk on Cray T3E-900; Windows98 and Windows XP on PCs. Programming language: FORTRAN 90 No. of lines in distributed program, including test data, etc.: 757 No. of bytes in distributed program, including test data, etc.: 9730 Distribution format: tar.gz Nature of physical problem: The NMR second moment reflects the strength of the nuclear magnetic dipole-dipole interaction in solids. This value can be extracted from the appropriate experiment and can be calculated on the basis of Van Vleck formula. The internal rotation of molecules or their parts averages this interaction decreasing the measured value of the NMR second moment. The analysis of the internal dynamics based on the NMR second moment measurements is as follows. The second moment is measured at different temperatures. On the other hand it is also calculated for different models and frequencies of this motion. Comparison of experimental and calculated values permits the building of the most probable model of internal dynamics in the studied material. The program described

  5. Reports and recommendations from COSPAR Planetary Exploration Committee (PEX) & International Lunar Exploration Working Group (ILEWG)

    NASA Astrophysics Data System (ADS)

    Ehrenfreund, Pascale; Foing, Bernard

    2014-05-01

    In response to the growing importance of space exploration, the objectives of the COSPAR Panel on Exploration (PEX) are to provide high quality, independent science input to support the development of a global space exploration program while working to safeguard the scientific assets of solar system bodies. PEX engages with COSPAR Commissions and Panels, science foundations, IAA, IAF, UN bodies, and IISL to support in particular national and international space exploration working groups and the new era of planetary exploration. COSPAR's input, as gathered by PEX, is intended to express the consensus view of the international scientific community and should ultimately provide a series of guidelines to support future space exploration activities and cooperative efforts, leading to outstanding scientific discoveries, opportunities for innovation, strategic partnerships, technology progression, and inspiration for people of all ages and cultures worldwide. We shall focus on the lunar exploration aspects, where the COSPAR PEX is building on previous COSPAR, ILEWG and community conferences. An updated COSPAR PEX report is published and available online (Ehrenfreund P. et al, COSPAR planetary exploration panel report, http://www.gwu.edu/~spi/assets/COSPAR_PEX2012.pdf). We celebrate 20 years after the 1st International Conference on Exploration and Utilisation of the Moon at Beatenberg in June 1994. The International Lunar Exploration Working Group (ILEWG) was established the year after in April 1995 at an EGS meeting in Hamburg, Germany. As established in its charter, this working group reports to COSPAR and is charged with developing an international strategy for the exploration of the Moon (http://sci.esa.int/ilewg/ ). It discusses coordination between missions, and a road map for future international lunar exploration and utilisation. It fosters information exchange or potential and real future lunar robotic and human missions, as well as for new scientific and

  6. Prognostic indicators in primary biliary cirrhosis: significance of revised IAHG (International Autoimmune Hepatitis Group) score

    PubMed Central

    Jung, Ho Eun; Jeong, Soung Won; Kim, Jin Nyoung; Jang, Hee Yoon; Cho, Yun Ju; Woo, Sung Ae; Lee, Sae Hwan; Kim, Sang Gyune; Cha, Sang-Woo; Kim, Young Seok; Cho, Young Deok; Kim, Hong Soo; Kim, Boo Sung

    2012-01-01

    Background/Aims Primary biliary cirrhosis (PBC) is a slowly progressing autoimmune disease of the liver that is characterized by portal inflammation and immune-mediated destruction of the intrahepatic bile ducts. Serum total bilirubin is one of the various prognostic factors that have been proposed. A recent study found that PBC with accompanying autoimmune hepatitis (AIH) carries a negative prognosis. This study examined the clinical characteristics of PBC and analyzed the factors that affect its prognosis. Methods Patients diagnosed with PBC between January 1998 and December 2010 based on clinical and histopathological findings were compiled and analyzed retrospectively. Results Among 27 patients, 24 (1 male and 23 females, ages 50.0±9.3 years) were followed up. The follow-up period was 8.6±0.9 years. Of the 24 patients, 9 patients progressed to liver cirrhosis (LC). Comparison between patients who did and did not progress to LC revealed statistically significant differences in the patients' serum total bilirubin (2.7±1.8 vs. 0.8±0.4, P=0.012), the Mayo risk score (5.1±0.7 vs. 3.9±0.6, P=0.001), the revised IAHG (International Autoimmune Hepatitis Group) score (9.2±2.3 vs. 5.4±3.0, P=0.004) and frequency of AIH overlap (5/9 [55.6%] vs. 0/15 [0%], P=0.001) at the time of diagnosis. Conclusions We propose that serum total bilirubin, the Mayo risk score, and the revised IAHG score at the time of diagnosis are helpful for predicting PBC prognosis. In particular, since all of the patients with accompanying AIH progressed to LC, the presence of overlap syndrome at the time of diagnosis is helpful for predicting PBC prognosis and providing an adequate treatment. PMID:23323253

  7. Impact of glycine-containing ORS solutions on stool output and duration of diarrhoea: a meta-analysis of seven clinical trials. The International Study Group on Improved ORS.

    PubMed Central

    1991-01-01

    The results are described of a meta-analysis of seven randomized trials that compared the clinical effects of the standard solution of WHO oral rehydration salts (ORS), containing 20 milligrams of glucose, and experimental ORS solutions, containing glycine, on 643 children with acute noncholera diarrhoea. The availability of data on individual patients in each trial permitted the scope of the meta-analysis to be enhanced because the data could be pooled after adjusting for differences in baseline patient characteristics; also, the statistical strategy in terms of data quality, post-randomization exclusion of patients, and regression modelling could be standardized for all trials. The results of the analysis showed that neither stool output nor duration of diarrhoea was reduced by the experimental formulations. Only for weight gain was there a statistically significant difference between the treatment groups (those given the WHO-ORS solution gained less weight). This probably reflects transient excess fluid retention within the gut lumen or tissues of the patients who received the glycine-containing solutions. ORS formulations that contain glycine are therefore not clinically superior to the WHO-ORS solution. PMID:1835674

  8. An Exploratory Study of Expert Group Leadership

    ERIC Educational Resources Information Center

    Rubel, Deborah J.; Kline, William B.

    2008-01-01

    This article presents the results of a grounded theory exploration that described expert group leaders' experiences and perceptions during the process of leading groups in terms of influence of experience, preexisting knowledge and attitudes, and in-the-moment leadership process. The discussion presents implications for practice, counselor…

  9. Human Factor Studies on a Mars Analogue During Crew 100b International Lunar Exploration Working Group EuroMoonMars Crew: Proposed New Approaches for Future Human Space and Interplanetary Missions

    PubMed Central

    Rai, Balwant; Kaur, Jasdeep

    2012-01-01

    Knowing the risks, costs, and complexities associated with human missions to Mars, analogue research can be a great (low-risk) tool for exploring the challenges associated with the preparation for living, operating, and undertaking research in interplanetary missions. Short-duration analogue studies, such as those being accomplished at the Mars Desert Research Station (MDRS), offer the chance to study mission operations and human factors in a simulated environment, and therefore contribute to exploration of the Moon and Mars in planned future missions. This article is based upon previously published articles, abstracts, and presentations by a series of independent authors, human factor studies performed on mars analogue station by Crew 100B. The MDRS Crew 100B performed studies over 15 days providing a unique insight into human factor issues in simulated short-duration Mars mission. In this study, 15 human factors were evaluated and analyzed by subjective and objective means, and from the summary of results it was concluded that optimum health of an individual and the crew as a whole is a necessity in order to encourage and maintain high performance and the satisfaction of project goals. PMID:23181225

  10. Human Factor Studies on a Mars Analogue During Crew 100b International Lunar Exploration Working Group EuroMoonMars Crew: Proposed New Approaches for Future Human Space and Interplanetary Missions.

    PubMed

    Rai, Balwant; Kaur, Jasdeep

    2012-11-01

    Knowing the risks, costs, and complexities associated with human missions to Mars, analogue research can be a great (low-risk) tool for exploring the challenges associated with the preparation for living, operating, and undertaking research in interplanetary missions. Short-duration analogue studies, such as those being accomplished at the Mars Desert Research Station (MDRS), offer the chance to study mission operations and human factors in a simulated environment, and therefore contribute to exploration of the Moon and Mars in planned future missions. This article is based upon previously published articles, abstracts, and presentations by a series of independent authors, human factor studies performed on mars analogue station by Crew 100B. The MDRS Crew 100B performed studies over 15 days providing a unique insight into human factor issues in simulated short-duration Mars mission. In this study, 15 human factors were evaluated and analyzed by subjective and objective means, and from the summary of results it was concluded that optimum health of an individual and the crew as a whole is a necessity in order to encourage and maintain high performance and the satisfaction of project goals. PMID:23181225

  11. Sector-Wide Approaches in Education: Issues for Donor Agencies Arising from Case Studies of Zambia and Mozambique. A Report from the Meeting of the International Working Group on Education (IWGE) (Lisbon, Portugal, November 19-21, 2001).

    ERIC Educational Resources Information Center

    Riddell, Abby

    This book contains two case studies--one from Zambia, one from Mozambique--of the implications for donors of pursuing sector-wide approaches (SWAps) in education. (A sector-wide approach is characterized as a sustained partnership led by national authorities involving different arms of government and, where relevant, donor agencies, with the goals…

  12. A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial

    PubMed Central

    2011-01-01

    Background Swine origin influenza A/H1N1 infection (H1N1) emerged in early 2009 and rapidly spread to humans. For most infected individuals, symptoms were mild and self-limited; however, a small number developed a more severe clinical syndrome characterized by profound respiratory failure with hospital mortality ranging from 10 to 30%. While supportive care and neuraminidase inhibitors are the main treatment for influenza, data from observational and interventional studies suggest that the course of influenza can be favorably influenced by agents not classically considered as influenza treatments. Multiple observational studies have suggested that HMGCoA reductase inhibitors (statins) can exert a class effect in attenuating inflammation. The Collaborative H1N1 Adjuvant Treatment (CHAT) Pilot Trial sought to investigate the feasibility of conducting a trial during a global pandemic in critically ill patients with H1N1 with the goal of informing the design of a larger trial powered to determine impact of statins on important outcomes. Methods/Design A multi-national, pilot randomized controlled trial (RCT) of once daily enteral rosuvastatin versus matched placebo administered for 14 days for the treatment of critically ill patients with suspected, probable or confirmed H1N1 infection. We propose to randomize 80 critically ill adults with a moderate to high index of suspicion for H1N1 infection who require mechanical ventilation and have received antiviral therapy for ≤ 72 hours. Site investigators, research coordinators and clinical pharmacists will be blinded to treatment assignment. Only research pharmacy staff will be aware of treatment assignment. We propose several approaches to informed consent including a priori consent from the substitute decision maker (SDM), waived and deferred consent. The primary outcome of the CHAT trial is the proportion of eligible patients enrolled in the study. Secondary outcomes will evaluate adherence to medication administration

  13. Learning in Groups: A Comparison of Study Groups and T Groups

    ERIC Educational Resources Information Center

    Klein, Edward B.; Astrachan, Boris M.

    1971-01-01

    This paper focuses on a comparison of two models, with special attention to the ways in which authority and peer relations are viewed. The need for theoretical and technical amalgamation to advance our understanding of group phenomena is stressed. A comment by James Crowfoot, University of Michigan follows. (Author)

  14. Professional Development in International Schools; Issues of Inclusion Identified by a Group of International School Teaching Assistants

    ERIC Educational Resources Information Center

    Tarry, Estelle; Cox, Anna

    2014-01-01

    With the growth in numbers of teaching assistants (TAs) in the UK, it has been identified through research carried out on behalf of the Council of British International Schools (COBIS) research that TAs in British international schools have specific and unmet training needs. Following the development of a course for TAs in international contexts,…

  15. Genetic polymorphism of N-acetyltransferases, glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase in relation to malignant and benign pancreatic disease risk. The International Pancreatic Disease Study Group.

    PubMed

    Bartsch, H; Malaveille, C; Lowenfels, A B; Maisonneuve, P; Hautefeuille, A; Boyle, P

    1998-06-01

    Carcinogens present in cigarette smoke and diet have been associated with pancreatic cancer. We hypothesized that heterocyclic and aromatic amines implicated in these exposures could be involved as causative agents and that therefore genetic variation in enzymes metabolizing these carcinogens could modify the risk of developing malignant and benign pancreatic disease. The effect of the genetic polymorphism of acetyltransferases (NAT1) and NAT2), glutathione S-transferase M1 (GSTM1) and NAD(P)H: quinone oxidoreductase 1 (NQO1) on the risk of pancreatic diseases (cancer, pancreatitis) was examined in a case-control study. PCR-based assays were used for genotype analysis of genomic DNA from whole blood cells. Samples collected from Caucasian patients with diagnosed pancreatic cancer (n = 81), with non-alcoholic (n = 41) and alcoholic pancreatitis (n = 73) and from asymptomatic control subjects (n = 78) were analysed. The prevalence of GSTM1 null genotype and of NAT2 fast and slow acetylator genotypes and the distribution of frequencies for NQO1 genotypes did not differ in subjects with pancreatic diseases vs controls. For NAT1 slow acetylators a non-significant excess (P = 0.18) was found among pancreatic cancer cases vs controls. There was a significant over-representation of the GSTM1 AB or B genotype in all pancreatic disease cases combined (OR = 2.6; P < 0.05). When concurrent controls were pooled with literature controls (n = 1427), OR was 1.4 (P = 0.08). The results of this study, requiring confirmation, suggest that the polymorphism of GSTM1 and NAT1 enzymes may be associated with a modest increase in susceptibility to pancreatic diseases. PMID:9696930

  16. International Cultural Immersion: Assessing the Influence of a Group Intervention on Intercultural Sensitivity for Counselor Trainees

    ERIC Educational Resources Information Center

    Barden, Sejal M.; Shannonhouse, Laura; Mobley, Keith

    2015-01-01

    Scholars (e.g., Bemak & Chung, 2004) underscore the need for group workers to be culturally sensitive. One group training strategy, cultural immersion, is often employed to develop cultural sensitivity. However, no studies have utilized quasi-experimental methodologies to assess differences in cultural sensitivity between trainees that immerse…

  17. IGORR-IV -- Proceedings of the fourth meeting of the International Group on Research Reactors

    SciTech Connect

    Rosenbalm, K.F.

    1995-12-31

    The International Group on Research Reactors was formed to facilitate the sharing of knowledge and experience among those institutions and individuals who are actively working to design, build, and promote new research reactors or to make significant upgrades to existing facilities. Twenty-nine papers were presented in five sessions and written versions of the papers or hard copies of the vugraphs used are published in these proceedings. The five sessions were: (1) Operating Research Reactors and Facility Upgrades; (2) Research Reactors in Design and Construction; (3) ANS Closeout Activities; (4) and (5) Research, Development, and Analysis Results.

  18. A Global Study of International Teacher Recruitment

    ERIC Educational Resources Information Center

    Cox, Dale S.

    2012-01-01

    International teacher recruiting is a complex, high stakes process that is crucial to schools' success. Competition for teachers is intensifying as the number of international schools increases globally. The number of international schools has more than doubled in recent years. With candidates and schools scattered throughout the world,…

  19. Whom to Group with--A Bourdieusian Narrative Analysis of International Students in an Australian University

    ERIC Educational Resources Information Center

    Lin, Isadora Jung-Hsiu

    2012-01-01

    Increasing degree-seeking international students from affluent Asian countries, who use English as an additional language (EAL), have contributed to cultural and linguistic diversity in Australian universities. However, such diversity posed challenges in pedagogy and assessment. Drawn from a larger interview study, exploring what resources helped…

  20. Factors Associated with Lack of Viral Suppression at Delivery among HAART-Naïve HIV-Positive Women in the International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) P1025 Study

    PubMed Central

    Katz, Ingrid T.; Leister, Erin; Kacanek, Deborah; Hughes, Michael D.; Bardeguez, Arlene; Livingston, Elizabeth; Stek, Alice; Shapiro, David E.; Tuomala, Ruth

    2014-01-01

    Background High delivery maternal plasma HIV-1 RNA level (viral load, VL) is a risk factor for mother to child transmission and poor maternal health. Objective To identify factors associated with detectable VL at delivery despite initiation of highly active antiretroviral therapy (HAART) during pregnancy. Design Multicenter observational study. Setting 67 US AIDS clinical research sites. Patients HIV-1-positive pregnant women who initiated HAART during pregnancy. Measurements Descriptive summaries and associations between socio-demographic, HIV disease, treatment and pregnancy-related risk factors and detectable VL (>400copies/mL) at delivery. Results Between October 2002 and December 2011, 671 women met inclusion criteria and 13% had detectable VL at delivery. Factors associated with detectable VL included multiparity (16.4% vs 8% nulliparous, p=0.002), black non-Hispanic ethnicity (17.6% vs 6.6% Hispanic and 6.6% white/non-Hispanic, p<0.001), 11th grade or less education (17.6% vs.12.1% high school graduate and 6.7% some college or higher, p=0.013), and initiation of HAART in third trimester (23.9% vs 12.3% second and 8.6% first, p=0.002), timing of HIV diagnosis prior to current pregnancy (16.1% vs 11% during current pregnancy, p=0.051), and timing of first prenatal visit in 3rd trimester (33.3% vs 14.3% second and 10.5% first, p=0.002). Women who experienced treatment interruptions or reported poor medication adherence during pregnancy were more likely to have detectable VL at delivery than women with no interruptions or who reported better adherence. Limitations Women entered the study at varying times during pregnancy and for this and other reasons there was incomplete data on many covariates. Conclusions In this large U.S.-based cohort of HIV-1 positive women, 13% of women who initiated HAART during pregnancy had detectable VL at delivery. The timing of HAART initiation and prenatal care along with medication adherence during pregnancy appear to be

  1. Differentiation and grouping of isolates of the Ganoderma lucidum complex by random amplified polymorphic DNA-PCR compared with grouping on the basis of internal transcribed spacer sequences.

    PubMed Central

    Hseu, R S; Wang, H H; Wang, H F; Moncalvo, J M

    1996-01-01

    Laccate polypores of the Ganoderma lucidum species complex are widespread white rot fungi of economic importance, but isolates cannot be identified by traditional taxonomic methods. Parsimony analysis of nucleotide sequences from the internal transcribed spacers (ITS) of the ribosomal gene (rDNA) distinguished six lineages in this species complex. Each ITS lineage may represent one or more putative species. While some isolates have identical ITS sequences, all of them could be clearly differentiated by genetic fingerprinting using random amplified polymorphic DNA (RAPD). To investigate the suitability of RAPD markers for taxonomic identification and grouping of isolates of the G. lucidum complex, RAPD fragments (RAPDs) were used as phenotypic characters in numerical and parsimony analyses. Results show that data from RAPDS do not distinguish the same clades as ITS data do. Groupings based on analysis of RAPD data were very sensitive to the choice of the grouping method used, and no consistent grouping of isolates could be proposed. However, analysis with RAPDs did resolve several robust terminal clades containing putatively conspecific isolates, suggesting that RAPDs might be helpful for systematics at the lower taxonomic levels that are unresolved by ITS sequence data. The limitations of RAPDs for systematics are briefly discussed. The conclusion of this study is that ITS sequences can be used to identify isolates of the G. lucidum complex, whereas RAPDs can be used to differentiate between isolates having identical ITS sequences. The practical implications of these results are briefly illustrated. PMID:8919797

  2. National facilities study. Volume 4: Space operations facilities task group

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The principal objectives of the National Facilities Study (NFS) were to: (1) determine where U.S. facilities do not meet national aerospace needs; (2) define new facilities required to make U.S. capabilities 'world class' where such improvements are in the national interest; (3) define where consolidation and phase-out of existing facilities is appropriate; and (4) develop a long-term national plan for world-class facility acquisition and shared usage. The Space Operations Facilities Task Group defined discrete tasks to accomplish the above objectives within the scope of the study. An assessment of national space operations facilities was conducted to determine the nation's capability to meet the requirements of space operations during the next 30 years. The mission model used in the study to define facility requirements is described in Volume 3. Based on this model, the major focus of the Task Group was to identify any substantive overlap or underutilization of space operations facilities and to identify any facility shortfalls that would necessitate facility upgrades or new facilities. The focus of this initial study was directed toward facility recommendations related to consolidations, closures, enhancements, and upgrades considered necessary to efficiently and effectively support the baseline requirements model. Activities related to identifying facility needs or recommendations for enhancing U.S. international competitiveness and achieving world-class capability, where appropriate, were deferred to a subsequent study phase.

  3. Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group Report.

    PubMed

    Collard, Harold R; Ryerson, Christopher J; Corte, Tamera J; Jenkins, Gisli; Kondoh, Yasuhiro; Lederer, David J; Lee, Joyce S; Maher, Toby M; Wells, Athol U; Antoniou, Katerina M; Behr, Juergen; Brown, Kevin K; Cottin, Vincent; Flaherty, Kevin R; Fukuoka, Junya; Hansell, David M; Johkoh, Takeshi; Kaminski, Naftali; Kim, Dong Soon; Kolb, Martin; Lynch, David A; Myers, Jeffrey L; Raghu, Ganesh; Richeldi, Luca; Taniguchi, Hiroyuki; Martinez, Fernando J

    2016-08-01

    Acute exacerbation of idiopathic pulmonary fibrosis has been defined as an acute, clinically significant, respiratory deterioration of unidentifiable cause. The objective of this international working group report on acute exacerbation of idiopathic pulmonary fibrosis was to provide a comprehensive update on the topic. A literature review was conducted to identify all relevant English text publications and abstracts. Evidence-based updates on the epidemiology, etiology, risk factors, prognosis, and management of acute exacerbations of idiopathic pulmonary fibrosis are provided. Finally, to better reflect the current state of knowledge and improve the feasibility of future research into its etiology and treatment, the working group proposes a new conceptual framework for acute respiratory deterioration in idiopathic pulmonary fibrosis and a revised definition and diagnostic criteria for acute exacerbation of idiopathic pulmonary fibrosis. PMID:27299520

  4. Children's Learning Groups: A Study of Emergent Leadership, Dominance, and Group Effectiveness.

    ERIC Educational Resources Information Center

    Yamaguchi, Ryoko

    This study explores the importance of the group context in the emergence of leadership, dominance, and group effectiveness in children's collaborative learning groups. Ten 3-person work groups performed a collaborative math activity. Using achievement goal orientation (Ames, 1992; Maehr and Midgley, 1996; Pintrich and Schunk, 1996) as a framework,…

  5. Cognitive Distance, Absorptive Capacity and Group Rationality: A Simulation Study

    PubMed Central

    Curşeu, Petru Lucian; Krehel, Oleh; Evers, Joep H. M.; Muntean, Adrian

    2014-01-01

    We report the results of a simulation study in which we explore the joint effect of group absorptive capacity (as the average individual rationality of the group members) and cognitive distance (as the distance between the most rational group member and the rest of the group) on the emergence of collective rationality in groups. We start from empirical results reported in the literature on group rationality as collective group level competence and use data on real-life groups of four and five to validate a mathematical model. We then use this mathematical model to predict group level scores from a variety of possible group configurations (varying both in cognitive distance and average individual rationality). Our results show that both group competence and cognitive distance are necessary conditions for emergent group rationality. Group configurations, in which the groups become more rational than the most rational group member, are groups scoring low on cognitive distance and scoring high on absorptive capacity. PMID:25314132

  6. Beyond Group-Threat: Temporal Dynamics of International Migration and Linkages to Anti-Foreigner Sentiment

    PubMed Central

    DeWaard, Jack

    2014-01-01

    Prior research on the association between country-level patterns of international migration and anti-foreigner sentiment shows that larger foreign-born concentrations increase perceptions of threat among native-born individuals in receiving countries, which, in turn, give rise to exclusionary preferences. While recent work has assembled a list of limiting conditions that shape the strength of this association, I argue that these efforts are premature because they are based on a narrow way of conceptualising and measuring international migration. In contrast to concepts and measures privileging the size of the foreign-born population in receiving countries, I draw from other literatures highlighting the temporal dynamics of migration. In considering the role of the temporal dynamics of international migration in explaining variation in anti-foreigner sentiment, the question is whether and how the temporal stability of the foreign-born population in receiving countries matters. My results suggest that it does. The size and temporal stability of the foreign-born population play opposing roles in aggravating and ameliorating anti-foreigner sentiment, respectively, with each operating via different pathways at the individual level. My work thus breaks new ground by challenging existing theoretical constructs and operationalisations in the group-threat literature. PMID:26146481

  7. ADHD in international adoptees: a national cohort study.

    PubMed

    Lindblad, Frank; Weitoft, Gunilla Ringbäck; Hjern, Anders

    2010-01-01

    Several investigators have reported an increased frequency of attention/hyperactivity symptoms in international adoptees, though population-based studies are lacking. In this national cohort study, we aimed to determine the prevalence of ADHD medication in international adoptees in Sweden, in comparison to the general population. A further purpose was to study gender, age at adoption and region of origin as predictors of ADHD medication in international adoptees. The study population consisted of all Swedish residents born in 1985-2000 with Swedish-born parents, divided into 16,134 adoptees, and a comparison population of 1,326,090. ADHD medications were identified in the Swedish Prescribed Drug Register during 2006. Logistic regression was used to calculate the odds ratios. The rates of ADHD medication were higher in international adoptees than in the comparison population for both boys (5.3 vs. 1.5% for 10-15-year olds) and girls (2.1 vs. 0.3% for 10-15-year olds). International adoptees from all regions of birth more often consumed ADHD medication compared with the majority population, but the age and sex adjusted odds ratios were particularly high for adoptees from Eastern Europe, Middle East/Africa and Latin America. Adjusting for maternal education and single parenthood increased the odds ratios even further. The risk also increased with higher age at adoption. Adoptees from Eastern Europe have a very high risk for ADHD medication. A structured identification and support programme should be tailored for this group. Adoptees from other regions have a more moderately increased risk, which should be communicated to adoptive parents and to professionals who care for adoptees in their clinical practice. PMID:19543791

  8. IGORR-1: Proceedings of the first meeting of the international group on research reactors

    SciTech Connect

    West, C.D.

    1990-05-01

    Many organizations, in several countries, are planning or implementing new or upgraded research reactor projects, but there has been no organized forum devoted entirely to discussion and exchange of information in this field. Over the past year or so, informal discussions resulted in widespread agreement that such a forum would serve a useful purpose. Accordingly, a proposal to form a group was submitted to the leading organizations known to be involved in projects to build or upgrade reactor facilities. Essentially all agreed to join in the formation of the International Group on Research Reactors (IGORR) and nominated a senior staff member to serve on its international organizing committee. The first IGORR meeting took place on February 28--March 2, 1990. It was very successful and well attended; some 52 scientists and engineers from 25 organizations in 10 countries participated in 2-1/2 days of open and informative presentations and discussions. Two workshop sessions offered opportunities for more detailed interaction among participants and resulted in identification of common R D needs, sources of data, and planned new facilities. Individual papers have been cataloged separately.

  9. Empirical Bayes for Group (DCM) Studies: A Reproducibility Study.

    PubMed

    Litvak, Vladimir; Garrido, Marta; Zeidman, Peter; Friston, Karl

    2015-01-01

    This technical note addresses some key reproducibility issues in the dynamic causal modelling of group studies of event related potentials. Specifically, we address the reproducibility of Bayesian model comparison (and inferences about model parameters) from three important perspectives namely: (i) reproducibility with independent data (obtained by averaging over odd and even trials); (ii) reproducibility over formally distinct models (namely, classic ERP and canonical microcircuit or CMC models); and (iii) reproducibility over inversion schemes (inversion of the grand average and estimation of group effects using empirical Bayes). Our hope was to illustrate the degree of reproducibility one can expect from DCM when analysing different data, under different models with different analyses. PMID:26733846

  10. Empirical Bayes for Group (DCM) Studies: A Reproducibility Study

    PubMed Central

    Litvak, Vladimir; Garrido, Marta; Zeidman, Peter; Friston, Karl

    2015-01-01

    This technical note addresses some key reproducibility issues in the dynamic causal modelling of group studies of event related potentials. Specifically, we address the reproducibility of Bayesian model comparison (and inferences about model parameters) from three important perspectives namely: (i) reproducibility with independent data (obtained by averaging over odd and even trials); (ii) reproducibility over formally distinct models (namely, classic ERP and canonical microcircuit or CMC models); and (iii) reproducibility over inversion schemes (inversion of the grand average and estimation of group effects using empirical Bayes). Our hope was to illustrate the degree of reproducibility one can expect from DCM when analysing different data, under different models with different analyses. PMID:26733846

  11. Archival Appraisal of Records of International Organizations: A RAMP Study with Guidelines.

    ERIC Educational Resources Information Center

    Guptil, Marilla B.

    Prepared under contract with the International Council on Archives (ICA), this study reviews past and present policies and procedures in the archival appraisal and disposal of noncurrent records (to the extent that such have been developed and implemented) by a representative group of international intergovernmental organizations. This study and…

  12. Women Physicists Speak: The 2001 International Study of Women in Physics.

    ERIC Educational Resources Information Center

    Ivie, Rachel; Czujko, Roman; Stowe, Katie

    The Working Group on Women in Physics of the International Union of Pure and Applied Physics (IUPAP) subcontracted with the American Institute of Physics to conduct an international study of women in physics in two phases. The first part was a benchmarking study to identify reliable sources and collect data on the representation of women in…

  13. An International Study of Research Misconduct Policies

    PubMed Central

    Resnik, David B.; Rasmussen, Lisa M.; Kissling, Grace E.

    2015-01-01

    Research misconduct is an international concern. Misconduct policies can play a crucial role in preventing and policing research misconduct, and many institutions have developed their own policies. While institutional policies play a key role in preventing and policing misconduct, national policies are also important to ensure consistent promulgation and enforcement of ethical standards. The purpose of this study was to obtain more information about research misconduct policies across the globe. We found that twenty-two of the top forty research and development funding countries (55%) had a national misconduct policy. Four countries (18.2%) are in the process of developing a policy, and four (18.2%) have a national research ethics code but no misconduct policy. All twenty-two countries (100%) with national policies included fabrication, falsification, and plagiarism in the definition of misconduct, but beyond that there was considerable diversity. Unethical authorship was mentioned in 54.6% of the misconduct definitions, followed by unethical publication practices (36.4%), conflict of interest mismanagement (36.4%), unethical peer review (31.8%), misconduct related to misconduct investigations (27.3%), poor record keeping (27.3%), other deception (27.3%), serious deviations (22.7%), violating confidentiality (22.7%), and human or animal research violations (22.7%). Having a national policy was positively associated with research and development funding ranking and intensiveness. To promote integrity in international research collaborations, countries should seek to harmonize and clarify misconduct definitions and develop procedures for adjudicating conflicts when harmonization does not occur. PMID:25928177

  14. Pulsation research during the IMS. [International Magnetospheric Study

    NASA Technical Reports Server (NTRS)

    Hughes, W. J.

    1982-01-01

    After describing the development status of the field of magnetic pulsations in 1975, before the initiation of the International Magnetospheric Study (IMS), attention is given to the IMS's novel observational results and an attempt is made to identify the most effective research methods employed. It is found that the most fruitful work involved small-scale collaboration between a few individuals or a few groups possessing complementary data sets. Consideration is restricted to research on the long period pulsations which can be broadly classified as field line resonances. Recommendations are made for future research efforts.

  15. [International multicenter studies of treatment of severe traumatic brain injury].

    PubMed

    Talypov, A E; Kordonsky, A Yu; Krylov, V V

    2016-01-01

    Despite the introduction of new diagnostic and therapeutic methods, traumatic brain injury (TBI) remains one of the leading cause of death and disability worldwide. Standards and recommendations on conservative and surgical treatment of TBI patients should be based on concepts and methods with proven efficacy. The authors present a review of studies of the treatment and surgery of severe TBI: DECRA, RESCUEicp, STITCH(TRAUMA), CRASH, CRASH-2, CAPTAIN, NABIS: H ll, Eurotherm 3235. Important recommendations of the international group IMPACT are considered. PMID:27045148

  16. Using Post-Study-Abroad Experiences to Enhance International Study

    ERIC Educational Resources Information Center

    Dean, Kevin W.; Jendzurski, Michael B.

    2013-01-01

    Many study abroad experiences offer opportunities for a broadened global perspective gleaned from interpersonal engagement with cultural others in an international setting. Unfortunately, and far too often, the campus majority who do not have this firsthand travel experience remain disengaged and might feel excluded. This article contends that…

  17. Community Report and Recommendations from International Lunar Exploration Working Group (ILEWG)

    NASA Astrophysics Data System (ADS)

    Foing, Bernard H.

    2016-07-01

    The International Lunar Exploration Working Group (ILEWG) was established in April 1995 at a meeting in Hamburg, Germany. As established in its charter, this working group reports to COSPAR and is charged with developing an international strategy for the exploration of the Moon. It discusses coordination between missions, and a road map for future international lunar exploration and utilisation. It fosters information exchange or potential and real future lunar robotic and human missions, as well as for new scientific and exploration information about the Moon. We refer to COSPAR and ILEWG ICEUM and lunar conferences and declarations [1-18], present the GLUC/ICEUM11 declaration and give a report on ongoing relevant ILEWG community activities. ILEWG supported community forums, ILEWG EuroMoonMars field campaigns and technology validation activities, as well as Young Lunar Explorers events, and activities with broad stakeholders. We discuss how lunar missions SMART-1, Kaguya, Chang'E1&2, Chandrayaan-1, LCROSS, LRO, GRAIL, LADEE, Chang'E3 and upcoming missions contribute to lunar exploration objectives & roadmap towards the Moon Village. GLUC/ICEUM11 declaration: "467 International Lunar Explorers, registered delegates from 26 countries, assembled at GLUC Global Lunar Conference including the 11th ILEWG Conference on Exploration and Utilisation of the Moon (ICEUM11) in Beijing. The conference engaged scientists, engineers, enthusiast explorers, agencies and organisations in the discussion of recent results and activities and the review of plans for exploration. Space agencies representatives gave the latest reports on their current lunar activities and programmes. GLUC-ICEUM11 was a truly historical meeting that demonstrated the world-wide interest in lunar exploration, discovery, and science. More than 400 abstracts were accepted for oral and poster presentations in the technical sessions, organised in 32 sessions within 4 symposia: Science and Exploration; Technology

  18. Computational Study of Platinum Group Superalloys

    NASA Astrophysics Data System (ADS)

    Popoola, A. I.; Lowther, J. E.

    2014-02-01

    Various properties of substitutional alloys formed from aluminium and the platinum group metals (PGMs) are examined using density functional (D-F) theory and show strong variations depending on metal type. A similar pattern for the binary alloys is observed using molecular dynamics modeling employing Sutton Chen potentials. All results suggest that several of the PGMs could have superior properties to the presently used Ni3Al alloy for high temperature applications. Some phases are predicted to be stable with extremely high melting temperatures (MTs).

  19. Association of American Geographers, Remote Sensing Specialty Group Special Issue of Geocarto International

    NASA Technical Reports Server (NTRS)

    Allen, Thomas R. (Editor); Emerson, Charles W. (Editor); Quattrochi, Dale A. (Editor); Arnold, James E. (Technical Monitor)

    2001-01-01

    This special issue continues the precedence of the Association of American Geographers (AAG), Remote Sensing Specialty Group (RSSG) for publishing selected articles in Geocarto International as a by-product from the AAG annual meeting. As editors, we issued earlier this year, a solicitation for papers to be published in a special issue of Geocarto International that were presented in RSSG-sponsored sessions at the 2001 AAG annual meeting held in New York City on February 27-March 3. Although not an absolute requisite for publication, the vast majority of the papers in this special issue were presented at this year's AAG meeting in New York. Other articles in this issue that were not part of a paper or poster session at the 2001 AAG meeting are authored by RSSG members. Under the auspices of the RSSG, this special Geocarto International issue provides even more compelling evidence of the inextricable linkage between remote sensing and geography. The papers in this special issue fall into four general themes: 1) Urban Analysis and Techniques for Urban Analysis; 2) Land Use/Land Cover Analysis; 3) Fire Modeling Assessment; and 4) Techniques. The first four papers herein are concerned with the use of remote sensing for analysis of urban areas, and with use or development of techniques to better characterize urban areas using remote sensing data. As the lead paper in this grouping, Rashed et al., examine the usage of spectral mixture analysis (SMA) for analyzing satellite imagery of urban areas as opposed to more 'standard' methods of classification. Here SMA has been applied to IRS-1C satellite multispectral imagery to extract measures that better describe the 'anatomy' of the greater Cairo, Egypt region. Following this paper, Weng and Lo describe how Landsat TM data have been used to monitor land cover types and to estimate biomass parameters within an urban environment. The research reported in this paper applies an integrated GIS (Geographic Information System

  20. Dialogical Approach Applied in Group Counselling: Case Study

    ERIC Educational Resources Information Center

    Koivuluhta, Merja; Puhakka, Helena

    2013-01-01

    This study utilizes structured group counselling and a dialogical approach to develop a group counselling intervention for students beginning a computer science education. The study assesses the outcomes of group counselling from the standpoint of the development of the students' self-observation. The research indicates that group counselling…

  1. Gender-based education during clerkships: a focus group study

    PubMed Central

    van Leerdam, Lotte; Rietveld, Lianne; Teunissen, Doreth; Lagro-Janssen, Antoine

    2014-01-01

    Objectives One of the goals of the medical master’s degree is for a student to become a gender-sensitive doctor by applying knowledge of gender differences in practice. This study aims to investigate, from the students’ perspective, whether gender medicine has been taught in daily practice during clerkship. Methods A focus group study was conducted among 29 medical students from Radboud University, Nijmegen, The Netherlands, who had just finished either their internal medicine or surgical clerkships. Data were analyzed in line with the principles of constant comparative analysis. Results Four focus groups were conducted with 29 participating students. Clinical teachers barely discuss gender differences during students’ clerkships. The students mentioned three main explanatory themes: insufficient knowledge; unawareness; and minor impact. As a result, students feel that they have insufficient competencies to become gender-sensitive doctors. Conclusion Medical students at our institution perceive that they have received limited exposure to gender-based education after completing two key clinical clerkships. All students feel that they have insufficient knowledge to become gender-sensitive doctors. They suppose that their clinical teachers have insufficient knowledge regarding gender sensitivity, are unaware of gender differences, and the students had the impression that gender is not regarded as an important issue. We suggest that the medical faculty should encourage clinical teachers to improve their knowledge and awareness of gender issues. PMID:24600301

  2. RECENT ACTIVITIES OF THE NUCLEAR SMUGGLING INTERNATIONAL TECHNICAL WORKING GROUP TO THWART ILLICIT TRAFFICKING

    SciTech Connect

    Smith, D K; Biro, T; Chartier, B; Mayer, K; Niemeyer, S; Thompson, P

    2007-10-25

    The Nuclear Smuggling International Technical Working Group (ITWG) is an informal association of nuclear forensic practitioners working in partnership with law enforcement, first responder, and nuclear regulatory professionals that cooperate to deter the illicit trafficking of nuclear materials. The objective of the ITWG is to advance the science of nuclear forensics and to provide a common approach and effective technical solutions to governments who request assistance. the ITWG was chartered in 1996 and since that time 30 nations and organizations have participated in 12 annual meetings and two analytical round-robin trials involving plutonium and highly enriched uranium. A third analytical round-robin as well as several table-top exercises are planned for later in 2007-2008. International interest in the ITWG has grown in over the past five years measured by the number of participants at its annual meetings. This growth has spawned the ITWG Nuclear Forensics Laboratories as a companion technical affiliate focusing exclusively on the scientific aspects of nuclear forensics and nuclear smuggling incident response.

  3. A Study of Group Dynamics in Educational Leadership Cohort and Non-Cohort Groups

    ERIC Educational Resources Information Center

    Greenlee, Bobbie J.; Karanxha, Zorka

    2010-01-01

    The purpose of this study was to examine group dynamics of educational leadership students in cohorts and make comparisons with the group dynamics characteristics of non-cohort students. Cohorts have emerged as dynamic and adaptive entities with attendant group dynamic processes that shape collective learning and action. Cohort (n=42) and…

  4. 76 FR 31017 - Advisory Group to the Internal Revenue Service Tax Exempt and Government Entities Division (TE/GE...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    ... Internal Revenue Service Advisory Group to the Internal Revenue Service Tax Exempt and Government Entities... Advisory Committee on Tax Exempt and Government Entities (ACT) will hold a public meeting on Wednesday... Tax Compliance. Federal, State and Local Governments: --Review of the Government Accountability...

  5. 77 FR 29755 - Advisory Group to the Internal Revenue Service Tax Exempt and Government Entities Division (TE/GE...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... Internal Revenue Service Advisory Group to the Internal Revenue Service Tax Exempt and Government Entities... Advisory Committee on Tax Exempt and Government Entities (ACT) will hold a public meeting on Wednesday... Governments and Their Members Tax Exempt Bonds: --A Survey of IRS Forms for Information Reporting Last...

  6. The Impact of Conflict on International Student Mobility: A Case Study of International Students Studying in Israel

    ERIC Educational Resources Information Center

    Ben-Tsur, Dalia

    2009-01-01

    This paper explores the impact of conflict on international student mobility. Through an examination of undergraduate, international students studying in Israel, this case study questions how and if a situation of ongoing violent conflict affects international student travel decisions to study in a host country. Contrary to assumptions of…

  7. Report of the School Finance Study Group.

    ERIC Educational Resources Information Center

    Wisconsin State Dept. of Public Instruction, Madison.

    This document reports the findings of a study assessing the status of school finance in Wisconsin and recommending preferred methods for funding the public schools. Seventy-nine topics were considered in five areas: state support, general aid, categorical aid, factors affecting school costs, and other topics. The study's recommendations regarding…

  8. Teachers' Stances towards Chinese International Students: An Australian Case Study

    ERIC Educational Resources Information Center

    Love, Kristina; Arkoudis, Sophie

    2006-01-01

    The international marketing of school education has gathered momentum in the Asia Pacific region, where an English medium education is prized by many parents. This paper investigates the responses of a group of teachers in Australia to the needs of international students in their school. The analysis of a 1 h professional discussion between four…

  9. Integrated thermal treatment systems study. Internal review panel report

    SciTech Connect

    Cudahy, J.; Escarda, T.; Gimpel, R.

    1995-04-01

    The U.S. Department of Energy (DOE) Office of Technology Development (OTD) commissioned two studies to evaluate nineteen thermal treatment technologies for treatment of DOE mixed low-level waste. These studies were called the Integrated Thermal Treatment System (ITTS) Phase I and Phase II. With the help of the DOE Office of Environmental Management (EM) Mixed Waste Focus Group, OTD formed an ITTS Internal Review Panel to review and comment on the ITTS studies. This Panel was composed of scientists and engineers from throughout the DOE complex, the U.S. Environmental Protection Agency, the California EPA, and private experts. The Panel met from November 15-18, 1994 to review the ITTS studies and to make recommendations on the most promising thermal treatment systems for DOE mixed low-level wastes and on research and development necessary to prove the performance of the technologies. This report describes the findings and presents the recommendations of the Panel.

  10. Computer Simulation in the Teaching of Translation and International Studies.

    ERIC Educational Resources Information Center

    Brecht, Richard D.; And Others

    1984-01-01

    Describes the National Simulation in International Studies and Translation Program which links international studies and foreign languages programs at a number of universities. This program provides a natural context for the exercise of translation for the language student and an authenticity of experience for students of international politics.…

  11. Internal NASA Study: NASAs Protoflight Research Initiative

    NASA Technical Reports Server (NTRS)

    Coan, Mary R.; Hirshorn, Steven R.; Moreland, Robert

    2015-01-01

    The NASA Protoflight Research Initiative is an internal NASA study conducted within the Office of the Chief Engineer to better understand the use of Protoflight within NASA. Extensive literature reviews and interviews with key NASA members with experience in both robotic and human spaceflight missions has resulted in three main conclusions and two observations. The first conclusion is that NASA's Protoflight method is not considered to be "prescriptive." The current policies and guidance allows each Program/Project to tailor the Protoflight approach to better meet their needs, goals and objectives. Second, Risk Management plays a key role in implementation of the Protoflight approach. Any deviations from full qualification will be based on the level of acceptable risk with guidance found in NPR 8705.4. Finally, over the past decade (2004 - 2014) only 6% of NASA's Protoflight missions and 6% of NASA's Full qualification missions experienced a publicly disclosed mission failure. In other words, the data indicates that the Protoflight approach, in and of it itself, does not increase the mission risk of in-flight failure. The first observation is that it would be beneficial to document the decision making process on the implementation and use of Protoflight. The second observation is that If a Project/Program chooses to use the Protoflight approach with relevant heritage, it is extremely important that the Program/Project Manager ensures that the current project's requirements falls within the heritage design, component, instrument and/or subsystem's requirements for both the planned and operational use, and that the documentation of the relevant heritage is comprehensive, sufficient and the decision well documented. To further benefit/inform this study, a recommendation to perform a deep dive into 30 missions with accessible data on their testing/verification methodology and decision process to research the differences between Protoflight and Full Qualification

  12. International Students' Employment Search in the United States: A Phenomenological Study

    ERIC Educational Resources Information Center

    Sangganjanavanich, Varunee Faii; Lenz, A. Stephen; Cavazos, Javier, Jr.

    2011-01-01

    After completing their academic degree, international student populations face unique situations in their search for employment in the United States. This study used a phenomenological examination to identify the perceptions and the experiences of eight undergraduate international students who participated in a 10-week support group during the…

  13. Early Risk Indicators of Internalizing Problems in Late Childhood: A 9-Year Longitudinal Study

    ERIC Educational Resources Information Center

    Ashford, Janka; Smit, Filip; van Lier, Pol A. C.; Cuijpers, Pim; Koot, Hans M.

    2008-01-01

    Background: Longitudinal studies on risk indicators of internalizing problems in childhood are in short supply, but could be valuable to identify target groups for prevention. Methods: Standardized assessments of 294 children's internalizing problems at the age of 2-3 years (parent report), 4-5 years (parent and teacher report) and 11 years…

  14. Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report.

    PubMed

    Palumbo, Antonio; Bringhen, Sara; Mateos, Maria-Victoria; Larocca, Alessandra; Facon, Thierry; Kumar, Shaji K; Offidani, Massimo; McCarthy, Philip; Evangelista, Andrea; Lonial, Sagar; Zweegman, Sonja; Musto, Pellegrino; Terpos, Evangelos; Belch, Andrew; Hajek, Roman; Ludwig, Heinz; Stewart, A Keith; Moreau, Philippe; Anderson, Kenneth; Einsele, Hermann; Durie, Brian G M; Dimopoulos, Meletios A; Landgren, Ola; San Miguel, Jesus F; Richardson, Paul; Sonneveld, Pieter; Rajkumar, S Vincent

    2015-03-26

    We conducted a pooled analysis of 869 individual newly diagnosed elderly patient data from 3 prospective trials. At diagnosis, a geriatric assessment had been performed. An additive scoring system (range 0-5), based on age, comorbidities, and cognitive and physical conditions, was developed to identify 3 groups: fit (score = 0, 39%), intermediate fitness (score = 1, 31%), and frail (score ≥2, 30%). The 3-year overall survival was 84% in fit, 76% in intermediate-fitness (hazard ratio [HR], 1.61; P = .042), and 57% in frail (HR, 3.57; P < .001) patients. The cumulative incidence of grade ≥3 nonhematologic adverse events at 12 months was 22.2% in fit, 26.4% in intermediate-fitness (HR, 1.23; P = .217), and 34.0% in frail (HR, 1.74; P < .001) patients. The cumulative incidence of treatment discontinuation at 12 months was 16.5% in fit, 20.8% in intermediate-fitness (HR, 1.41; P = .052), and 31.2% in frail (HR, 2.21; P < .001) patients. Our frailty score predicts mortality and the risk of toxicity in elderly myeloma patients. The International Myeloma Working group proposes this score for the measurement of frailty in designing future clinical trials. These trials are registered at www.clinicaltrials.gov as #NCT01093136 (EMN01), #NCT01190787 (26866138MMY2069), and #NCT01346787 (IST-CAR-506). PMID:25628469

  15. PREFACE: Seventh International Workshop: Group Analysis of Differential Equations and Integrable Systems (GADEISVII)

    NASA Astrophysics Data System (ADS)

    Vaneeva, Olena; Sophocleous, Christodoulos; Popovych, Roman; Boyko, Vyacheslav; Damianou, Pantelis

    2015-06-01

    The Seventh International Workshop "Group Analysis of Differential Equations and Integrable Systems" (GADEIS-VII) took place at Flamingo Beach Hotel, Larnaca, Cyprus during the period June 15-19, 2014. Fifty nine scientists from nineteen countries participated in the Workshop, and forty one lectures were presented. The Workshop topics ranged from theoretical developments of group analysis of differential equations, hypersymplectic structures, theory of Lie algebras, integrability and superintegrability to their applications in various fields. The Series of Workshops is a joint initiative by the Department of Mathematics and Statistics, University of Cyprus, and the Department of Applied Research of the Institute of Mathematics, National Academy of Sciences, Ukraine. The Workshops evolved from close collaboration among Cypriot and Ukrainian scientists. The first three meetings were held at the Athalassa campus of the University of Cyprus (October 27, 2005, September 25-28, 2006, and October 4-5, 2007). The fourth (October 26-30, 2008), the fifth (June 6-10, 2010) and the sixth (June 17-21, 2012) meetings were held at the coastal resort of Protaras. We would like to thank all the authors who have published papers in the Proceedings. All of the papers have been reviewed by at least two independent referees. We express our appreciation of the care taken by the referees. Their constructive suggestions have improved most of the papers. The importance of peer review in the maintenance of high standards of scientific research can never be overstated. Olena Vaneeva, Christodoulos Sophocleous, Roman Popovych, Vyacheslav Boyko, Pantelis Damianou

  16. Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report

    PubMed Central

    Bringhen, Sara; Mateos, Maria-Victoria; Larocca, Alessandra; Facon, Thierry; Kumar, Shaji K.; Offidani, Massimo; McCarthy, Philip; Evangelista, Andrea; Lonial, Sagar; Zweegman, Sonja; Musto, Pellegrino; Terpos, Evangelos; Belch, Andrew; Hajek, Roman; Ludwig, Heinz; Stewart, A. Keith; Moreau, Philippe; Anderson, Kenneth; Einsele, Hermann; Durie, Brian G. M.; Dimopoulos, Meletios A.; Landgren, Ola; San Miguel, Jesus F.; Richardson, Paul; Sonneveld, Pieter; Rajkumar, S. Vincent

    2015-01-01

    We conducted a pooled analysis of 869 individual newly diagnosed elderly patient data from 3 prospective trials. At diagnosis, a geriatric assessment had been performed. An additive scoring system (range 0-5), based on age, comorbidities, and cognitive and physical conditions, was developed to identify 3 groups: fit (score = 0, 39%), intermediate fitness (score = 1, 31%), and frail (score ≥2, 30%). The 3-year overall survival was 84% in fit, 76% in intermediate-fitness (hazard ratio [HR], 1.61; P = .042), and 57% in frail (HR, 3.57; P < .001) patients. The cumulative incidence of grade ≥3 nonhematologic adverse events at 12 months was 22.2% in fit, 26.4% in intermediate-fitness (HR, 1.23; P = .217), and 34.0% in frail (HR, 1.74; P < .001) patients. The cumulative incidence of treatment discontinuation at 12 months was 16.5% in fit, 20.8% in intermediate-fitness (HR, 1.41; P = .052), and 31.2% in frail (HR, 2.21; P < .001) patients. Our frailty score predicts mortality and the risk of toxicity in elderly myeloma patients. The International Myeloma Working group proposes this score for the measurement of frailty in designing future clinical trials. These trials are registered at www.clinicaltrials.gov as #NCT01093136 (EMN01), #NCT01190787 (26866138MMY2069), and #NCT01346787 (IST-CAR-506). PMID:25628469

  17. Losing Control: Conducting Studies with Comparison Groups

    ERIC Educational Resources Information Center

    Norton, Jan

    2006-01-01

    Studies in education often report the differences between participants' and non-participants' test scores, course grades, retention, and other criteria. When participants' average performance is higher, it can be difficult to attribute the improvements to participation. Comparing participants and non-participants on other measures can strengthen…

  18. Facilitating Professional Development through Teacher Study Groups

    ERIC Educational Resources Information Center

    Thomas, La' Toya

    2010-01-01

    Differentiated instruction is a way of teaching, which gives students multiple choices to learn information. Fourth grade teachers at one elementary school were not implementing the differentiated instructional techniques that would help them address the learning needs of their students. The purpose of this project study was to create a teacher…

  19. Cluster Analysis in Minority Group Poverty Studies.

    ERIC Educational Resources Information Center

    Ross, E. Lamar

    This paper, one of a series which arose out of data gathered on Choctaw Indians, Negroes, and whites in a low income area of Mississippi, expands upon one aspect of a recently completed analysis by the author. In the study, an attempt was made to distinguish between the characteristics associated with income levels and those related to ethnic…

  20. Mongolism, Ciba Foundation Study Group Number 25.

    ERIC Educational Resources Information Center

    Wolstenholme, G. E. W., Ed.; Porter, Ruth, Ed.

    Resulting from a 1-day conference on mongolism, the book contains research studies and discussion summaries. Papers include "Parental Age, Live-Birth Order, and Pregnancy-Free Interval in Down's Syndrome in Japan" by E. Matsunaga, "Consanguineous Marriages and Mongolism" by H. Foressman and H. O. Akesson, "Correlation of Dermal Patterns on…

  1. Group Work Experiences: Domestic MBA Student Experiences and Outcomes when Working with International Students

    ERIC Educational Resources Information Center

    Rafferty, Patricia D.

    2013-01-01

    This article forms part of an exploration into the results of a single-case, embedded study that was conducted to explore how domestic part-time graduate business students in the United States experience group work for summative assessment. Multiple information collection methods were utilised, including open-ended and semi-structured interviews,…

  2. An International Strategy for Human Exploration of the Moon: The International Space Exploration Coordination Group (ISECG) Reference Architecture for Human Lunar Exploration

    NASA Technical Reports Server (NTRS)

    Laurini, Kathleen C.; Hufenbach, Bernhard; Junichiro, Kawaguchi; Piedboeuf, Jean-Claude; Schade, Britta; Lorenzoni, Andrea; Curtis, Jeremy; Hae-Dong, Kim

    2010-01-01

    The International Space Exploration Coordination Group (ISECG) was established in response to The Global Exploration Strategy: The Framework for Coordination developed by fourteen space agencies and released in May 2007. Several ISECG participating space agencies have been studying concepts for human exploration of the moon that allow individual and collective goals and objectives to be met. This 18 month study activity culminated with the development of the ISECG Reference Architecture for Human Lunar Exploration. The reference architecture is a series of elements delivered over time in a flexible and evolvable campaign. This paper will describe the reference architecture and how it will inform near-term and long-term programmatic planning within interested agencies. The reference architecture is intended to serve as a global point of departure conceptual architecture that enables individual agency investments in technology development and demonstration, International Space Station research and technology demonstration, terrestrial analog studies, and robotic precursor missions to contribute towards the eventual implementation of a human lunar exploration scenario which reflects the concepts and priorities established to date. It also serves to create opportunities for partnerships that will support evolution of this concept and its eventual realization. The ISECG Reference Architecture for Human Lunar Exploration (commonly referred to as the lunar gPoD) reflects the agency commitments to finding an effective balance between conducting important scientific investigations of and from the moon, as well as demonstrating and mastering the technologies and capabilities to send humans farther into the Solar System. The lunar gPoD begins with a robust robotic precursor phase that demonstrates technologies and capabilities considered important for the success of the campaign. Robotic missions will inform the human missions and buy down risks. Human exploration will start

  3. Conformations and Barriers to Methyl Group Internal Rotation in Two Asymmetric Ethers: Propyl Methyl Ether and Butyl Methyl Ether

    NASA Astrophysics Data System (ADS)

    Long, B. E.; Dechirico, F.; Cooke, S. A.

    2012-06-01

    The conformational preferences of the O-C-C-C unit are important in many biological systems with the unit generally preferring a gauche configuration compared to an anti configuration. Butyl methyl ether and propyl methyl ether provide very simple systems for this phenomenom to manifest. Pure rotational spectra of the title molecules have been recorded using chirped pulse Fourier transform microwave spectroscopy (CP-FTMW). In the case of butyl methyl ether, only one conformer has been observed. This conformer has torsional angles of COCC = 180°, OCCC = 62° and CCCC = 180° (anti-gauche-anti) and rotational constants of A = 10259.4591(33) MHz, B = 1445.6470(13) MHz, and C = 1356.2944(14) MHz. The rotational spectrum was doubled and has been analyzed to produce an effective barrier to methyl group internal rotation of 780(35) cm-1. A prior rotational spectroscopic study on propyl methyl ether had focused only on the high energy anti-anti conformer. We have analyzed spectra from the lowest energy anti-gauche conformer and the spectroscopic constants will be presented. A summary of the differences in conformational energies and methyl group internal rotation barriers for the class of aliphatic asymmetric ethers will be presented. K. N. Houk, J. E. Eksterowicz, Y.-D. Wu, C. D. Fuglesang, D. B. Mitchell. J. Am. Chem. Soc. 115 (4170), 1993. Hiroshi Kato, Jun Nakagawa, Michiro Hayashi. J. Mol. Spectrosc. 80 (272), 1980.

  4. International Computer and Information Literacy Study: ICILS 2013 User Guide for the International Database

    ERIC Educational Resources Information Center

    Jung, Michael, Ed.; Carstens, Ralph, Ed.

    2015-01-01

    The International Computer and Information Literacy Study (ICILS) 2013, conducted by the International Association for the Evaluation of Educational Achievement (IEA), studied how students in different countries develop the knowledge, understanding, attitudes, dispositions, and skills that comprise computer and information literacy (CIL). The aim…

  5. 76 FR 37207 - Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims and Appeals...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ...This document contains amendments to interim final regulations implementing the requirements regarding internal claims and appeals and external review processes for group health plans and health insurance coverage in the group and individual markets under provisions of the Affordable Care Act. These rules are intended to respond to feedback from a wide range of stakeholders on the interim......

  6. 77 FR 36031 - ROK Entertainment Group, Inc., RussOil Corp., Tricell, Inc., Tunex International, Inc. (n/k/a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION ROK Entertainment Group, Inc., RussOil Corp., Tricell, Inc., Tunex International, Inc. (n/k/a Aone... accurate information concerning the securities of ROK Entertainment Group, Inc. because it has not...

  7. International Students' Networks: A Case Study in a UK University

    ERIC Educational Resources Information Center

    Taha, Nashrawan; Cox, Andrew

    2016-01-01

    The great influx of international students into UK universities has led to internationalisation becoming an important issue. Previous studies have focused on the integration of home and international students, illustrating a lack of intercultural interaction. Yet there has been a lack of research investigating international students' networks and…

  8. Internal anal sphincter: an anatomic study.

    PubMed

    Uz, A; Elhan, A; Ersoy, M; Tekdemir, I

    2004-01-01

    The anatomy of the internal anal sphincter and surrounding structures was investigated in 24 cadavers using a surgical microscope (6-25 x magnification). An understanding of the anatomy of the internal anal sphincter is helpful in avoiding complications during surgical procedures in the anorectal region. The external anal sphincter was composed of three ellipsoid rings of skeletal muscle (subcutaneous, superficial, and deep) that encircle the anal canal; in contrast, we found that the internal anal sphincter was composed of flat rings of smooth muscle bundles stacked one on top of the other, like the slats of a Venetian blind. In each anal canal, the average number of ring-like slats observed was 26.33 +/- 2.93 (range = 20-30) and each was covered by its own fascia. The smooth muscle fibers and fascia coalesced at three equidistant points around the anal canal to form three columns that extended distally into the lumen and differed in form from the other anal columns. When viewed from an anterior position, the columns were located anteriorly at the observer's right (5 o'clock position), posteriorly at the right (1 o'clock position), and laterally at the left (9 o'clock position). This heretofore unreported anatomy of the internal anal sphincter may play an important role in closing off the lumen of the anal canal and maintaining bowel continence. PMID:14695582

  9. A Study and Simulation of International Trade.

    ERIC Educational Resources Information Center

    Hilke, Eileen Veronica; Skrentny, Ray

    1990-01-01

    Illustrates a fifth grade teaching unit on international economics. Gives suggestions for use at the lower elementary and primary grades and points out that incorporation of economics into the elementary education curriculum can produce economically literate citizens in a cost-effective way. (GG)

  10. Development and dematerialization: an international study.

    PubMed

    Steinberger, Julia K; Krausmann, Fridolin; Getzner, Michael; Schandl, Heinz; West, Jim

    2013-01-01

    Economic development and growth depend on growing levels of resource use, and result in environmental impacts from large scale resource extraction and emissions of waste. In this study, we examine the resource dependency of economic activities over the past several decades for a set of countries comprising developing, emerging and mature industrialized economies. Rather than a single universal industrial development pathway, we find a diversity of economic dependencies on material use, made evident through cluster analysis. We conduct tests for relative and absolute decoupling of the economy from material use, and compare these with similar tests for decoupling from carbon emissions, both for single countries and country groupings using panel analysis. We show that, over the longer term, emerging and developing countries tend to have significantly larger material-economic coupling than mature industrialized economies (although this effect may be enhanced by trade patterns), but that the contrary is true for short-term coupling. Moreover, we demonstrate that absolute dematerialization limits economic growth rates, while the successful industrialization of developing countries inevitably requires a strong material component. Alternative development priorities are thus urgently needed both for mature and emerging economies: reducing absolute consumption levels for the former, and avoiding the trap of resource-intensive economic and human development for the latter. PMID:24204555