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1

Frameless image guidance improves accuracy in three-dimensional interstitial brachytherapy needle placement  

SciTech Connect

Purpose: The aim of this work was to adapt a computer-assisted real-time three-dimensional (3D) navigation system for interstitial brachytherapy procedures. Methods and materials: The 3-D navigation system Surgical Planning and Orientation Computer System (SPOCS; Aesculap, Tuttlingen, Germany) was adapted for use in interstitial brachytherapy. A special needle holder with mounted infrared-emitting diodes (IRED) for 3D navigation-based needle implantation was developed. Measurements were made on a series of different phantoms to study the feasibility and the overall accuracy and precision of the navigation system with regard to single-needle application and volume implants (multiple-needle implantations). In all, 250 single implants and 20 volume implants were performed. Accuracy was measured as the target registration error (TRE) between the preoperatively defined and the achieved target position. Results: Analyses of the 250 different targets showed a mean TRE for single-needle applications of 1.1 mm (SD {+-} 0.4 mm), 0.9 mm (SD {+-} 0.3 mm), and 0.7 mm (SD {+-} 0.3 mm) in the x, y, and z direction, respectively. The maximal deviation was 2.3 mm. The corresponding TRE in the x, y, and z direction for volume implants was 1.6 mm (SD {+-} 0.4 mm), 1.9 mm (SD {+-} 0.6 mm), and 1.0 mm (SD {+-} 0.4 mm), respectively. The maximum deviation was 2.9 mm. Conclusions: The adaptation of a commercially available surgical planning and navigation system to interstitial brachytherapy is feasible. It enables virtual planning and improved accuracy in 3D interstitial needle implantation.

Krempien, Robert [Department of Clinical Radiology, University of Heidelberg, Heidelberg (Germany)]. E-mail: robert_krempien@med.uni-heidelberg.de; Hassfeld, Stefan [Clinic for Cranio-Maxillo-Facial Surgery, University of Heidelberg, Heidelberg (Germany); Kozak, Josef [Aesculap, AG and CoKG, Tuttlingen (Germany); Tuemmler, Hans-Peter [Aesculap, AG and CoKG, Tuttlingen (Germany); Daeuber, Sascha [Institute for Process Control and Robotics, University of Karlsruhe - TH, Karlsruhe (Germany); Treiber, Martina [Department of Clinical Radiology, University of Heidelberg, Heidelberg (Germany); Debus, Juergen [Department of Clinical Radiology, University of Heidelberg, Heidelberg (Germany); Harms, Wolfgang [Department of Clinical Radiology, University of Heidelberg, Heidelberg (Germany)

2004-12-01

2

Study of metal distribution in pine and spruce needles  

SciTech Connect

This study was performed to assess the conditions for foliar uptake of air-borne metallic pollutants on pine and spruce needles. Needles of coniferous trees (Picea abies, Pinus sylvestris, Pinus strobus) were sampled at three locations in the Protected Landscape Area Elbe Sandstone in the Czech Republic. Solid (CR) and water-soluble (WS) fractions of aerosol adhered to the needle surface, and epicuticular waxes were separated from the needle by the two-step stripping procedure. The WS and CR fractions and the needle body after the stripping procedure were separately analyzed for 24 metals. The quantity of each fraction and its elemental composition is discussed regarding the tree species, needle age and locality. Highest aerosol quantities as well as concentration of metals were found in pine needles (Pinus strobus) from the locality most exposed to the local pollution sources. Epicuticular waxes were analyzed for As, Cd and Pb. The concentrations range from 0.1 to 1.2 {micro}g/g for As and Pb, and from 0.2 to 0.6 {micro}g/g for Cd. The highest metal concentrations were found in waxes of pines (Pinus sylvestris). Values of As and Pb concentration differences between WS fraction and the wax, between the wax and the needle body decrease with the needle age while Cd concentration differences do not depend on the needle age.

Hovorka, J. [Charles Univ., Prague (Czech Republic). Inst. of Environmental Studies; Marshall, G.B. [Univ. of London (United Kingdom). Birkbeck College; Bauer, P. [Administration of Protected Landscape Area Elbe Sandstone, Decin (Czech Republic)

1995-12-31

3

Metallic sewing needle ingestion presenting as acute abdomen.  

PubMed

We reported an unusual case of a 26-year-old man presenting to surgical emergency as generalized peritonitis following an ingestion of multiple metallic sewing needles. The X-ray of his abdomen showed pneumoperitoneum and multiple metallic foreign bodies in the abdominal cavity. An ultrasonogram of his abdomen showed multiple metallic foreign bodies in the abdominal cavity and urinary bladder. Emergency exploratory laparotomy was performed. On laparotomy, gastric and duodenal perforation was found through which metallic sewing needles were protruding out. A peritoneal lavage was done, and all the sewing needles were extracted from the perforation site, paracolic gutter, liver parenchyma, and urinary bladder. The primary repair of the perforation with omental patching was done with the drainage of subhepatic space and pelvic cavity. These multiple ingested sewing needles led to the perforation of the stomach and the duodenum, which resulted in perforation peritonitis. PMID:23974755

Misra, S; Jain, V; Ahmad, F; Kumar, R; Kishore, N

2013-01-01

4

Photoacoustic imaging of clinical metal needles in tissue.  

PubMed

The ability to visualize and track temporarily or permanently implanted metal devices is important in many applications ranging from diagnosis to therapy. Specifically, reliable imaging of metal needles is required in today's clinical settings. Currently, ultrasound is utilized to image a needle inserted into tissue in real time. However, the diagnostic value and tracking ability of these images depends highly on the orientation of the needle, and also its proximity to regions of interest in the tissue. We examine the use of photoacoustic imaging combined with current ultrasound imaging methods to obtain high-contrast images of commonly used needles in the body. Experiments were performed using 21 G and 30 G needles inserted into ex vivo porcine tissue and tissue-mimicking phantoms. The needles and surrounding tissue were imaged using an ultrasound imaging system interfaced with the pulsed laser source necessary for photoacoustic imaging. The results suggest that photoacoustic imaging, combined with ultrasound imaging, is capable of real-time, high-contrast, and high-spatial-resolution visualization of metal implants within anatomical landmarks of the background tissue. PMID:20459231

Su, Jimmy; Karpiouk, Andrei; Wang, Bo; Emelianov, Stanislav

2010-01-01

5

Photoacoustic imaging of clinical metal needles in tissue  

NASA Astrophysics Data System (ADS)

The ability to visualize and track temporarily or permanently implanted metal devices is important in many applications ranging from diagnosis to therapy. Specifically, reliable imaging of metal needles is required in today's clinical settings. Currently, ultrasound is utilized to image a needle inserted into tissue in real time. However, the diagnostic value and tracking ability of these images depends highly on the orientation of the needle, and also its proximity to regions of interest in the tissue. We examine the use of photoacoustic imaging combined with current ultrasound imaging methods to obtain high-contrast images of commonly used needles in the body. Experiments were performed using 21 G and 30 G needles inserted into ex vivo porcine tissue and tissue-mimicking phantoms. The needles and surrounding tissue were imaged using an ultrasound imaging system interfaced with the pulsed laser source necessary for photoacoustic imaging. The results suggest that photoacoustic imaging, combined with ultrasound imaging, is capable of real-time, high-contrast, and high-spatial-resolution visualization of metal implants within anatomical landmarks of the background tissue.

Su, Jimmy; Karpiouk, Andrei; Wang, Bo; Emelianov, Stanislav

2010-03-01

6

Small-Polaronic Diffusion of Light Interstitials in bcc Metals  

Microsoft Academic Search

The small-polaronic diffusion associated with simple models of light interstitials in bcc metals has been investigated. By transcending the simplifications which are often introduced in studying electronic small-polaron transport, we calculate diffusion coefficients which are reasonably consistent with available data. In particular, an explanation of the \\

David Emin; M. I. Baskes; W. D. Wilson

1979-01-01

7

[Diffuse interstitial pulmonary fibrosis. Responsibility of hard metals].  

PubMed

In a factory processing Tungsten carbide and hard metals, of a hundred exposed workers, 15 showed signs of "irritation" which progressed in 5 to clinical, radiological and functional pulmonary fibrosis with altered CO transport. In one patient histological sections were studied and typical findings of dust inclusion seen. Diffuse interstitial fibrosis related to heavy metals is still not yet recognised as an industrial disease in France. PMID:1153297

Baudouin, J; Jobard, P; Moline, J; Lavandier, M; Roullier, A; Homasson, J P

1975-05-01

8

Needle-free interstitial fluid acquisition using a Lorentz-force actuated jet injector  

E-print Network

Interstitial fluid (ISF) provides information on a patient's health as it contains regulatory molecules that are correlated with disease-related processes. However, current ISF acquisition techniques can be slow, resulting ...

Chang, Jean H

2014-01-01

9

COMPARISON OF THE METHODS FOR COLLECTING INTERSTITIAL WATER FOR TRACE ORGANIC COMPOUNDS AND METAL ANALYSES  

EPA Science Inventory

Several common materials and methods used to collect interstitial water were evaluated to determine their effect on the accuracy and precision of measured concentrations of selected organic compounds and metals. e compared the concentration of pollutants in doses seawater before ...

10

Reduction of decomposition rates of scots pine needle litter due to heavy-metal pollution  

Microsoft Academic Search

Decomposition of unpolluted Scots pine needle litter was studied in two heavy-metal-pollution gradients in Sweden; one near a brass mill and the other around a primary smelter. In the latter area locally collected polluted Scots pine needle litter was also incubated. Decomposition rates were strongly influenced by the metal pollution and a decrease in the rate of mass-loss occurred. In

Björn Berg; Gunnar Ekbohm; Bengt Söderström; Håkan Staaf

1991-01-01

11

Production and migration of interstitials in deformed metals  

NASA Astrophysics Data System (ADS)

An investigation was made of defect production during plastic deformation. Prior to cold-rolling, samples of Au were damaged and preannealed at temperatures in order to maximize site fractions of five different In-vacancy defect complexes, such as In-1V and In-2V. Evolutions of site fractions were monitored by perturbed ?-? angular correlation spectroscopy after additional strains at 77 K. Observed transformations between sites are consistent with defect-antidefect annihilation reactions between the small complexes and mobile interstitials, and indicate a large production of interstitials during deformation. An extended defect complex attributed to a planar faulted loop became glissile under small strain.

Shropshire, Steven L.; Collins, Gary S.

1990-08-01

12

Phonons in quantum solids with defects. [lattice vacancies and interstitials in solid helium and metallic hydrogen  

NASA Technical Reports Server (NTRS)

A formalism was developed for temperature-dependent, self-consistent phonons in quantum solids with defects. Lattice vacancies and interstitials in solid helium and metallic hydrogen, as well as electronic excitations in solid helium, were treated as defects that modify properties of these systems. The information to be gained from the modified phonon spectrum is discussed.

Jacobi, N.; Zmuidzinas, J. S.

1974-01-01

13

Ultralow contact resistance at an epitaxial metal/oxide heterojunction through interstitial site doping.  

PubMed

Heteroepitaxial growth of Cr metal on Nb-doped SrTiO?(001) is accompanied by Cr diffusion to interstitial sites within the first few atomic planes, an anchoring of the Cr film to the substrate, charge transfer from Cr to Ti, and metallization of the near-surface region, as depicted in the figure. The contact resistance of the resulting interface is exceedingly low. PMID:23649872

Chambers, Scott A; Gu, Meng; Sushko, Peter V; Yang, Hao; Wang, Chongmin; Browning, Nigel D

2013-08-01

14

Direct metal micropatterning on needle-type structures towards bioimpedance and chemical sensing applications  

NASA Astrophysics Data System (ADS)

Direct metal patterning methods, such as screen printing, inkjet printing and gravure/flexography printing, are widely used to form electrodes or interconnections for printed electronic devices due to their inexpensive, simple and rapid fabrication as compared to vacuum-based conventional metallization processes. Here, we present direct metal patterning by modified screen printing on the curved surface of needle-type rod structures (i.e. rods with radius of ? < 1?mm). We achieved various microscale patterns such as straight lines, zigzag lines, wavy lines and alphabetic words with a minimum width of 70?µm on the surface of the rod. Also, four pairs of line patterns were printed on the single rod for electrical interconnection. Printed patterns on the surface of the rod were used as electrodes for the control of a light emission diode (LED) as well as the real-time electrochemical impedance spectroscopy of electrolyte solutions and solid objects by the rod insertion. Furthermore, needles with multiple pairs of microelectrodes were used to measure the electrical impedance of biological samples such as fat and muscle tissues of porcine meat. In addition, a needle-type probe sensor with gas sensing capability was demonstrated by using a needle with printed Ag electrodes and Pd thin films.

Kim, Sanghyeok; Park, Jae-ho; Kang, Kyungnam; Park, Chong-Ook; Park, Inkyu

2015-01-01

15

Giant-cell interstitial pneumonia and hard-metal pneumoconiosis. A clinicopathologic study of four cases and review of the literature  

SciTech Connect

We report four cases of giant-cell interstitial pneumonia that occurred in association with exposure to hard metals. All patients presented with chronic interstitial lung disease and had open-lung biopsies that revealed marked interstitial fibrosis, cellular interstitial infiltrates, and prominent intraalveolar macrophages as well as giant cells displaying cellular cannibalism. We also review the literature to determine the sensitivity and specificity of giant-cell interstitial pneumonia for hard-metal pneumoconiosis. Although hard-metal pneumoconiosis may take the form of usual interstitial pneumonia, desquamative interstitial pneumonia, and giant-cell interstitial pneumonia, the finding of giant-cell interstitial pneumonia is almost pathognomonic of hard-metal disease and should provoke an investigation of occupational exposure. 25 references.

Ohori, N.P.; Sciurba, F.C.; Owens, G.R.; Hodgson, M.J.; Yousem, S.A.

1989-07-01

16

Ultra-low contact resistance at an epitaxial metal/oxide heterojunction through interstitial site doping  

SciTech Connect

The ability to form reliable, low-resistance Ohmic contacts is of critical importance to the ongoing development of oxide electronics. Most metals form Schottky barriers when deposited on oxide surfaces. Ohmic contacts rarely occur, and the associated contact resistances are not particularly low. Little is known at an atomistic level about what leads to a good Ohmic contact on a wide-gap oxide. Here we describe the structure of a simple, yet exceptionally low-contact resistance Ohmic metal on an important oxide semiconductor -- epitaxial Cr on Nb-doped SrTiO3(001). Heteroepitaxial growth is accompanied by Cr diffusion into the STO and occupation of interstitial sites within the first few atomic planes. Interstitial Cr is ionized and the resulting electrons occupy the STO conduction band, resulting in effective metallization near the interface.

Chambers, Scott A.; Gu, Meng; Sushko, Petr V.; Yang, Hao; Wang, Chong M.; Browning, Nigel D.

2013-08-07

17

The volume increase of fcc metals and alloys due to interstitial hydrogen over a wide range of hydrogen contents  

Microsoft Academic Search

Interstitial hydrogen contents and their associated volume increments have been determined for a variety of fcc metals and alloys. Using high pressure techniques, hydrogen contents approaching n = 1, where n = H-to-metal (atomic ratio), have been obtained. Despite electronic and initial volume differences amongst the fcc metallic matrices, all data fall onto a common relationship.

B. Baranowski; S. Majchrzak; T. B. Flanagan

1971-01-01

18

An observational study of giant cell interstitial pneumonia and lung fibrosis in hard metal lung disease  

PubMed Central

Background Hard metal lung disease has various pathological patterns including giant cell interstitial pneumonia (GIP) and usual interstitial pneumonia (UIP). Although the UIP pattern is considered the prominent feature in advanced disease, it is unknown whether GIP finally progresses to the UIP pattern. Objectives To clarify clinical, pathological and elemental differences between the GIP and UIP patterns in hard metal lung disease. Methods A cross-sectional study of patients from 17 institutes participating in the 10th annual meeting of the Tokyo Research Group for Diffuse Parenchymal Lung Diseases, 2009. Nineteen patients (seven female) diagnosed with hard metal lung disease by the presence of tungsten in lung specimens were studied. Results Fourteen cases were pathologically diagnosed as GIP or centrilobular inflammation/fibrosing. The other five cases were the UIP pattern or upper lobe fibrosis. Elemental analyses of lung specimens of GIP showed tungsten throughout the centrilobular fibrotic areas. In the UIP pattern, tungsten was detected in the periarteriolar area with subpleural fibrosis, but no association with centrilobular fibrosis or inflammatory cell infiltration. The GIP group was younger (43.1 vs 58.6?years), with shorter exposure duration (73 vs 285?months; p<0.01), lower serum KL-6 (398 vs 710?U/mL) and higher lymphocyte percentage in bronchoalveolar lavage fluid (31.5% vs 3.22%; p<0.05) than the fibrosis group. Conclusions The UIP pattern or upper lobe fibrosis is remarkably different from GIP in distribution of hard metal elements, associated interstitial inflammation and fibrosis, and clinical features. In hard metal lung disease, the UIP pattern or upper lobe fibrosis may not be an advanced form of GIP. PMID:24674995

Tanaka, Junichi; Moriyama, Hiroshi; Terada, Masaki; Takada, Toshinori; Suzuki, Eiichi; Narita, Ichiei; Kawabata, Yoshinori; Yamaguchi, Tetsuo; Hebisawa, Akira; Sakai, Fumikazu; Arakawa, Hiroaki

2014-01-01

19

Interstitial thermoradiotherapy  

SciTech Connect

The results of a phase I clinical trial in which heat was combined with interstitial (low dose rate) radiation are described with emphasis on response and technical and physical aspects of heating. We treated 25 patients (27 lesions) using interstitial implants to locally recurrent, accessible tumors heated by radiofrequency currents to 43 degrees -45 degrees C for 30 minutes, with needle guides as electrodes. They were subsequently irradiated with either 192Ir or 226Ra. All patients had failed previous conventional treatments including surgery, chemotherapy, and, in most, near tolerance doses of irradiation. In all but one, a single hyperthermic treatment was given and the average dose of low dose irradiation was under 3,000 rad over 60 hours. No patient failed to respond, 63% achieved a complete disappearance of tumor in the treated volume, and 37% had partial response (50% less than volume reduction less than 100%). Duration of response was from 2 to 30 months, and no patient showed regrowth at the site treated. Normal tissue complications were minimal. Interstitial thermoradiotherapy is both a safe and an effective means of treatment in advanced or recurrent accessible disease.

Manning, M.R.; Cetas, T.C.; Gerner, E.W.

1982-06-01

20

Predicting the toxicity of metal-spiked laboratory sediments using acid-volatile sulfide and interstitial water normalizations  

Microsoft Academic Search

Numerous studies have shown that dry weight concentrations of metals in sediments cannot be used to predict toxicity across sediments. However, several studies using sediments from both freshwater and saltwater have shown that interstitial water concentration or normalization involving acid-volatile sulfide (AVS) can be used to predict toxicity in sediments contaminated with cadmium, copper, nickel, lead, or zinc across a

W. J. Berry; D. J. Hansen; W. S. Boothman; J. D. Mahony; D. L. Robson; D. M. di Toro; B. P. Shipley; B. Rogers; J. M. Corbin

1996-01-01

21

Production of needle-type liquid-metal ion sources and their application in a scanning ion muscope  

NASA Astrophysics Data System (ADS)

A tungsten wire is electrochemically etched in NaOH to produce tip radii of 4-10 ?m for use in liquid-metal ion sources (LMIS). To ensure complete wetting of the needle with the liquid metal (Sn, Ga), the needle has to be annealed at 800-1000°C by electron bombardment in a vacuum. It is then immediately dipped into the liquid metal in the same vacuum chamber. An anode prepared in this way is part of a triode system, followed by an octupole stigmator, an electrostatic einzel lens and the scanning unit. Upon application of a high voltage the liquid metal will form a Taylor cone at the needle tip. In the resulting high electrical field ions are extracted through field evaporation. Typical beam current and spot size values during scanning ion muscope (SIM) operation are 2.5 ?A and 10 ?m respectively. An Everhart-Thornley detector and a quadrupole mass spectrometer are available to allow analysis of secondary particles emitted from the target.

Knapp, Helmut; Rübesame, Detlef; Niedrig, Heinz

1991-07-01

22

Giant cell interstitial pneumonia in a hard-metal worker. Cytologic, histologic and analytical electron microscopic investigation  

Microsoft Academic Search

A case of biopsy-proven giant cell interstitial pneumonia in a patient with occupational exposure to hard-metal dust is reported. Bronchial washings performed several days prior to open-lung biopsy yielded an almost exclusive population of nonpigmented alveolar macrophages and pleomorphic, phagocytic multinucleated giant cells. Microorganisms, viral inclusions in the giant cells, epithelioid histiocytes and well-formed granulomas were not seen. This cytologic

K. Tabatowski; V. L. Roggli; W. J. Fulkerson; R. L. Langley; T. Benning; W. W. Johnston

1988-01-01

23

Computer simulation of vacancy and interstitial clusters in bcc and fcc metals  

Microsoft Academic Search

Interstitial clusters in bcc-Fe and fcc-Cu and vacancy clusters in fcc-Cu have been studied by computer simulation using different types of interatomic potentials such as a short-ranged empirical pair potential of Johnson type, short-ranged many-body potentials of Finnis-Sinclair type and long-ranged pair potentials obtained within the generalized pseudopotential theory. The stability of a self interstitial in bcc-Fe was found to

Yu. N. Osetsky; M. Victoria; A. Serra; S. I. Golubov; V. Priego

1997-01-01

24

Giant cell interstitial pneumonia in a hard-metal worker. Cytologic, histologic and analytical electron microscopic investigation  

SciTech Connect

A case of biopsy-proven giant cell interstitial pneumonia in a patient with occupational exposure to hard-metal dust is reported. Bronchial washings performed several days prior to open-lung biopsy yielded an almost exclusive population of nonpigmented alveolar macrophages and pleomorphic, phagocytic multinucleated giant cells. Microorganisms, viral inclusions in the giant cells, epithelioid histiocytes and well-formed granulomas were not seen. This cytologic picture strongly suggests the presence of giant cell interstitial pneumonia in a patient with restrictive lung disease, particularly when exposure to hard-metal dust is known or suspected. A specific diagnosis early in the course of the disease may facilitate removal of the individual from the workplace and forestall the development of end-stage interstitial fibrosis. Additionally, the working environment may be modified to minimize inhalational exposure. Recognition of this entity by the cytopathologist may direct diagnostic efforts toward accurate histologic evaluation and the identification of particulates by microprobe analysis of either cellular or biopsy material.

Tabatowski, K.; Roggli, V.L.; Fulkerson, W.J.; Langley, R.L.; Benning, T.; Johnston, W.W.

1988-03-01

25

Interstitial cystitis  

MedlinePLUS

Cystitis - interstitial; IC ... bladder is almost full. If you have interstitial cystitis, the signal to empty your bladder is sent ... intercourse Many people who have long-term interstitial cystitis are also depressed because of the pain and ...

26

Determination of the interstitial electron density in liquid metals: Basic quantity to calculate the ion collective-mode velocity and related properties  

NASA Astrophysics Data System (ADS)

Considering that various investigations identified a correlation between the interstitial electron density in crystalline metals and some ground-state properties, including the compressibility, we propose a procedure to estimate the interstitial electron density in liquid metals starting from the experimental static structure factor. From the calculated electron density, starting from the standard approximation, which describes a liquid metal as made up of a homogeneous classic ion plasma with Coulomb interaction and a homogeneous interacting electron gas, we determine the ion collective mode velocity. The so-derived collective mode velocity is compared to the experimental data and a coherent view in different metallic systems at the melting point is obtained. Some guess about the collective mode damping is also presented because of the connection to the local static fluctuations of the interstitial electron density.

Sani, L.; Petrillo, C.; Sacchetti, F.

2014-07-01

27

Predicting the toxicity of metal-spiked laboratory sediments using acid-volatile sulfide and interstitial water normalizations  

SciTech Connect

Numerous studies have shown that dry weight concentrations of metals in sediments cannot be used to predict toxicity across sediments. However, several studies using sediments from both freshwater and saltwater have shown that interstitial water concentration or normalization involving acid-volatile sulfide (AVS) can be used to predict toxicity in sediments contaminated with cadmium, copper, nickel, lead, or zinc across a wide range of sediment types. Six separate experiments were conducted in which two or three sediments of varying AVS concentration were spiked with a series of concentrations of cadmium, copper, lead, nickel, or zinc or a mixture of four of these metals. The amphipod Ampelisca abdita was then exposed to the sediments in 10-d toxicity tests. Amphipod mortality was sediment dependent when plotted against dry weight metals concentration but was not sediment dependent when plotted against simultaneously extracted metal (SEM)/AVS or interstitial water toxic units (IWTUs). Sediments with SEM/AVS ratios < 1.0 were seldom toxic, while sediments with SEM/AVS ratios > 1.0 were frequently toxic. Similarly, sediments with < 0.5 IWTU were seldom toxic (3.0%), while sediments with > 0.5 IWTU were toxic 94.4% of the time. These results, coupled with results from related studies, demonstrate that an understanding of the fundamental chemical reactions which control the availability of cadmium, copper, lead, nickel, and zinc in sediments can be used to explain observed biological responses. The authors believe that using SEM/AVS ratios and IWTUs allows for more accurate predictions of acute mortality, with better casual linkage to metal concentration, than is possible with sediment evaluation tools which rely on dry weight metal concentrations.

Berry, W.J.; Hansen, D.J.; Boothman, W.S. [Environmental Protection Agency, Narragansett, RI (United States); Mahony, J.D. [Manhattan Coll., New York, NY (United States). Dept. of Environmental Engineering; Robson, D.L. [Rhode Island Dept. of Environmental Management, Providence, RI (United States); Toro, D.M. di [HydroQual, Mahwah, NJ (United States); Shipley, B.P. [Springborn Labs., Wareham, MA (United States); Rogers, B. [Science Applications International Corp., Narragansett, RI (United States); Corbin, J.M. [Texas Natural Resource Conservation Commission, Austin, TX (United States)

1996-12-01

28

INTERACTION OF METALS AND ORGAINIC CARBON COLLOIDS IN ANOXIC INTERSTITIAL WATERS OF MARINE SEDIMENTS  

EPA Science Inventory

Marine colloids are an important component of natural water geochemistry critical to the cycling, speciation and bioavailability of metals in marine sediments. In sediment, metals exist in three phases: particulate, colloidal and dissolved. Dissolved metal concentrations have bee...

29

ROLE OF ACID-VOLATILE SULFIDE AND INTERSTITIAL WATER METAL CONCENTRATIONS IN DETERMINING BIOAVAILABILITY OF CADMIUM AND NICKEL FROM CONTAMINATED SEDIMENTS TO THE MARINE POLYCHAETE NEANTHES ARENACEODENTATA  

EPA Science Inventory

This study investigated the influence of acid-volatile sulfide (AVS) and interstitial water (IW) metal concentrations on bioavailability and toxicity of Cd and Ni to an infaunal sediment-ingesting marine worm, Neanthes arenaceodentata. end exposures were conducted with sediments,...

30

The role of acid-volatile sulfide and interstitial water metal concentrations in determining bioavailability of cadmium and nickel from contaminated sediments to the marine polychaete Neanthes arenaceodentata  

SciTech Connect

This study investigated the influence of acid-volatile sulfide (AVS) and interstitial water (IW) metal concentrations on bioavailability and toxicity of Cd and Ni to an infaunal sediment-ingesting marine worm, Neanthes Arenaceodentata. Ten-d exposures were conducted with sediments, contaminated primarily with Cd and Ni, from Foundry Cove (Hudson River, NY), and with uncontaminated sediments spiked with Cd or Ni. Molar ratios of simultaneously extracted metal (SEM)/AVS ranged from < 0.02 to 44 for Cd-spiked, 0.02 to 241 for Ni-spiked, and <0.06 to 125 for Foundry Cove sediments. In all experiments, significant mortality was not observed when SEM/AVS ratios were <1.0 and interstitial water toxic units (IWTU) were <1.0. In the Cd and Ni-spiked experiments, when SEM/AVS ratios or IWTUs were >1.0, sediments were either lethal or worms did not burrow. Mortality of worms in Foundry Cove sediments was [le] 20%, and worms burrowed in all these sediments. However, IW contained <1.0 TU (Ni + Cd) in all Foundry Cove sediments except one (IWTU = 1.69). Metal concentrations in worms generally increased with increases in sediment metal concentration, SEM/AVS molar ratio, and IW metal concentration. The presence of metal in worms from sediments from SEM/AVS ratios <1.0 may be evidence of release of Cd or Ni from oxidized metal sulfide (a result of burrowing), uptake of metal from ingested sediment, or adsorption to body surfaces. These results support the hypothesis that when the concentration of AVS in sediments exceeds that of divalent metals sediments will not be acutely toxic. However, a greater number of sediments was correctly predicted to be nontoxic when interstitial water metal concentration of <1.0 TU was used.

Pesch, C.E.; Hansen, D.J.; Boothman, W.S. (Environmental Protection Agency, Narragansett, RI (United States). Environmental Research Lab.); Berry, W.J. (Science Applications International Corp., Narragansett, RI (United States)); Mahony, J.D. (Manhattan Coll., Bronx, NY (United States). Chemistry Dept.)

1995-01-01

31

Linking heavy metal bioavailability (Cd, Cu, Zn and Pb) in Scots pine needles to soil properties in reclaimed mine areas  

E-print Network

in reclaimed mine areas Marcin Pietrzykowski a,b, , Jaroslaw Socha c , Natalie S. van Doorn d a Department needles on mine soils was studied. · Element content of needles is good criterion in the assessment Accepted 3 October 2013 Available online 26 October 2013 Keywords: Post-mine sites Mine soils Trace

Battles, John

32

Metallic taste”: search for the needle in a haystack (exemplary diagnostic measures and successful minimal invasive endoscopic treatment of a needle-like copper-containing foreign body in the gastric wall)  

PubMed Central

Chronic complaints and non-specific symptoms are always challenging for the selection of adequate diagnostic management and therapeutic decision making (eg, in uncharacteristic metallic taste). In this extraordinary, but exemplary case, the successful outcome for a 51-year-old woman with a chronic complaint of metallic taste (believed to be the first report in the literature as a cause of copper overload) is described. The patient underwent, after appropriate diagnostic measures, including MRI (detection), laboratory analysis of serum copper level (increased) and endoscopic ultrasound scan (localising the site), a minimal invasive treatment using endoscopic mucosectomy to remove a detected needle-like copper-containing foreign body from the intramural site of the gastric wall. PMID:21686616

Will, Uwe; Eger, Horst; Hartmut, Schweikart; Meyer, Frank

2009-01-01

33

Interstitial keratitis  

MedlinePLUS

... cornea. This condition is often caused by infections. Syphilis is the most common cause of interstitial keratitis, ... Tuberculosis In the United States, most cases of syphilis are recognized and treated before this eye condition ...

34

CONTRIBUTION OF AMMONIA, METALS AND NONPOLAR ORGANIC COMPOUNDS TO THE TOXICITY OF SEDIMENT INTERSTITIAL WATER FROM AN ILLINOIS RIVER TRIBUTARY  

EPA Science Inventory

Toxicity of Illinois River bulk sediment, sediment interstitial (pore) water and elutriates to the oligochaete Lumbriculus variegatus, fathead minnow (Pimephales promelas) and the amphipod Hyalella azteca was compared to determine the most representative aqueous fraction for toxi...

35

Interstitial lung disease and asthma in hard-metal workers: bronchoalveolar lavage, ultrastructural, and analytical findings and results of bronchial provocation tests.  

PubMed Central

Five patients with respiratory disorders associated with hard metal exposure are described. In four patients electron microprobe analysis of bronchoalveolar lavage cells or lung tissue was used to show tungsten and other hard-metal components. Three patients had interstitial pneumonia and fibrosis with unusual multinucleate giant cells. Electron microscopy showed that the giant cells comprised both type II alveolar epithelial cells and alveolar macrophages. The multinucleate macrophages formed a distinctive feature of the bronchoalveolar lavage material but the multinucleate alveolar epithelial lining cells were evident only in lung tissue. The other two patients both suffered from work-related asthma, one of whom also had pulmonary opacities. Bronchial provocation tests in these patients supported the diagnosis of hard-metal-induced asthma and implicated cobalt as the agent responsible. Images PMID:6857569

Davison, A G; Haslam, P L; Corrin, B; Coutts, I I; Dewar, A; Riding, W D; Studdy, P R; Newman-Taylor, A J

1983-01-01

36

THE EFFECT OF INTERSTITIAL ATOM-DISLOCATION INTERACTIONS ON THE DEFORMATION BEHAVIOR OF SOME BODY-CENTERED-CUBIC METALS  

Microsoft Academic Search

The strain aging behavior of arc-melted niobium and tantalum, 1020 ; steel, and hydrogenated niobium was investigated using yield-point return and ; dynamic modulus of elasticity measurements to study the aging process. ; Comparison of activation energies for strain aging with those for interstitial ; diffusion revealed that hydrogen was responsible for dislocation locking in ; niobium, and probably in

1962-01-01

37

Interstitial implant with interstitial hyperthermia  

SciTech Connect

A Phase I Pilot Study combining interstitial or intracavitary irradiation using /sup 192/Ir or /sup 137/Cs and interstitial hyperthermia in advanced or recurrent tumors is underway at the City of Hope National Medical Center. Hyperthermia is performed using 0.5 megahertz RF (500 kilohertz) radiofrequency localized current fields. In the implanted volume, a temperature of 41/sup 0/ to 45/sup 0/C is maintained for 30 to 40 minutes. Hyperthermia is performed prior to irradiation in all patients. All patients had either failed previous conventional treatments, including surgery, chemotherapy and/or radiation therapy, or had advanced malignant tumors which were not felt to be controllable by conventional means. Sixteen lesions were implanted in 15 patients. Of the 16 lesions, 11/16 (68%) achieved complete response, and three had no response or recurred locally. The six patients (100%) receiving interstitial implant and hyperthermia as the primary therapy achieved complete response. Normal tissue complications were minimal. Range of response was three to 13 months. Interstitial thermoradiotherapy appears to be a safe and promising mode of therapy in advanced or recurrent accessible malignant tumors.

Vora, N.; Forell, B.; Joseph, C.; Lipsett, J.; Archambeau, J.D.

1982-12-01

38

Interstitial Lung Disease  

MedlinePLUS

... MS Dept. of Medicine View full profile Interstitial Lung Disease (ILD): Overview Interstitial lung disease (ILD) is ... they may make informed decisions Learn more. Interstitial Lung Disease Program As a center specializing in the ...

39

[Idiopathic interstitial pneumonias].  

PubMed

Idiopathic interstitial pneumonias represent approximately 30% of all interstitial lung diseases. The new classification of idiopathic interstitial pneumonias published in 2013 distinguishes 6 major entities, including chronic fibrosing forms (idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia), acute/subacute forms (cryptogenic organizing pneumonia and acute interstitial pneumonia) and smoking-related disorders (respiratory bronchiolitis interstitial lung disease and desquamative interstitial pneumonia). Pleuroparenchymal fibroelastosis is individualized as a new rare clinco-pathologic entity. For cases not fitting any specific clinic- pathological category, a pragmatic classification based on disease behavior is proposed. PMID:25362773

Lazor, Romain; Letovanec, Igor; Beigelman, Catherine

2014-09-01

40

Interstitial Cystitis (IC) Diet  

MedlinePLUS

Interstitial Cystitis (IC) Diet There is a lot of information on the web promoting various diets for interstitial cystitis (IC). Both the IC ... At this time, there is no special “IC Diet.” Research has found that there is a lot ...

41

Buffon's Needle Experiment  

NSDL National Science Digital Library

This resource consists of a Java applet and expository text. The applet simulates Buffon's needle experiment and the corresponding approximation of pi. The event of interest is that the needle crosses a crack. The length of the needle can be varied. The applet illustrates a random experiment, the sample space, random variables, probability, and relative frequency.

Siegrist, Kyle

42

Explicit studies of the quantum theory of light interstitial diffusion  

Microsoft Academic Search

however physical differences between electronic diffusion in an insulator and interstitial diffusion in a metal. As a result of these differences, simplifications which are employed in developing the nonadiabatic theory are often inappropriate for instances of light interstitial diffusion in metals. In the present work the formalism associated with small-polaron diffusion in the high-temperature semiclassical regime (valid above some fraction,

David Emin; M. I. Baskes; W. D. Wilson

1979-01-01

43

Unusual properties of interstitial copper oxides  

NASA Astrophysics Data System (ADS)

The quaternary oxides Ba 2YCu 3O 6.5+ x, Ba 2GdCu 3O 6.5+ x and Li 8Mg 4Cu 12 O 20+ x with constant 2:1:3 ratio of metal atoms can be treated as pseudobinary oxides MO z with variable oxygen content at octahedral interstitial sites of bcc M=Ba 2YCu 3, Ba 2G dCu 3 or fcc M=Li 8Mg 4Cu 12 derivative structure. Some properties of interstitial oxides are similar as in interstitial hydrides: Order-disorder transitions, metastable phases, spinodal decomposition, decrepitation, void formation, corrosion.

Hauck, J.; Bickmann, K.; Bischof, B.; Ipta, S.; Würtz, E. M.

1988-07-01

44

Examination of surface conditions and other physical properties of commonly used stainless steel acupuncture needles  

PubMed Central

Objectives The present work examined the surface conditions and various other physical properties of sterilised single-use stainless steel acupuncture needles from two of the most popular brands widely used in many countries. Methods Scanning electron microscope (SEM) images were taken for 10 randomly chosen needles from each brand. Further SEM images were taken after each of these needles underwent a standard manipulation with an acupuncture needling practice gel. A comparison of forces and torques during the needling process was also carried out. Results The SEM images revealed significant surface irregularities and inconsistencies at the needle tips, especially for needles from one of the two brands. Metallic lumps and small, loosely attached pieces of material were observed on the surfaces of some needles. Some of the lumps and pieces of material seen on the needle surfaces disappeared after the acupuncture manipulation. If these needles had been used on patients, the metallic lumps and small pieces of material could have been deposited in human tissues, which could have caused adverse events such as dermatitis. Malformed needle tips might also cause other adverse effects including bleeding, haematoma/bruising, or strong pain during needling. An off-centre needle tip could result in the needle altering its direction during insertion and consequently failing to reach the intended acupuncture point or damaging adjacent tissues. Conclusions These findings highlight the need for improved quality control of acupuncture needles, with a view to further enhancing the safety and comfort of acupuncture users. PMID:24522003

Xie, Yi Min; Xu, Shanqing; Zhang, Claire Shuiqing; Xue, Charlie Changli

2014-01-01

45

Buffon's Needle (MSTE)  

NSDL National Science Digital Library

Buffon's Needle, first stated in 1777, is one of the oldest problems in the field of geometrical probability. It involves dropping a needle on a lined sheet of paper and determining the probability of the needle crossing one of the lines on the page. The remarkable result is that the probability is directly related to the value of pi. These pages present an analytical solution.

Math Forum

2001-01-01

46

Role of Interstitial Brachytherapy in the Treatment of Malignant Disease  

Microsoft Academic Search

SummaryInterstitial brachytherapy was first applied using radium needles, with minimum protection of physicians and nurses. Modern techniques involve the use of radionuclide 192Ir as the source used in computer-controlled remote afterloading machines, which can deliver a high dose rate (HDR). Treatment planning is also undertaken with the use of computers and anatomical cross-section images using CT, ultrasound and MRI. This

C. Kolotas; N. Zamboglou

2001-01-01

47

Unified theory of kink dragging with a special reference to the flow stress and the Snoek-Köster relaxation in anisotropic body-centered-cubic metals with heavy interstitials  

NASA Astrophysics Data System (ADS)

The drag force acting on a kink moving rigidly and uniformly along the dislocation line and in the atmosphere of mobile octahedral (heavy) interstitials is investigated numerically in anisotropic body-centered-cubic metals. It is shown by extensive computer modeling experiments that the drag force versus normalized kink velocity plot goes through a maximum which is composed of three subpeaks, one acoustic and two optical in character. The acoustic part and the optical mode-2 are strongly and selectively associated with the isotropic and the pure shear parts of the elastic dipole tensor of the interstitial species, respectively. An extremely accurate and the concise analytical expression is deduced for the linear viscosity regime which exhibits the behavior of Navier-Stokes fluids, which can be used directly in Snoek-Köster relaxation. The flow stress theory of Seeger for the ultrahigh-purity body-centered-cubic metals is extended and coupled with the present treatment of the kink dragging which yields an excellent agreement with the dynamical strain aging experiments in Fe-C and Fe-N alloys.

Ogurtani, Tarik Ö.; Seeger, Alfred K.

1985-01-01

48

Magnetism driven by non-metal interstitials from first-principles prediction: The case of hydrogen- and fluorine-doped calcium monoxide with rock-salt structure  

NASA Astrophysics Data System (ADS)

Our first-principles calculations based on density functional theory confirmed the formation of sp-ferromagnetic states of calcium monoxide with interstitial nonmagnetic F or H atoms. The hydrogen and fluorine interstitials in the oxides were found to be spin polarized and are more stable in the antiferromagnetic state and the ferromagnetic state, respectively. For H-doped CaO, no considerable charge transfer takes place and the spin remains localized on the impurity. For F-doped oxide, the observation may be attributed to the p-p interaction and the charge transfer between the interstitial atom and the neighboring O atoms. We demonstrate that H-doped compound is a potential n-type antiferromagnet, while F-doped material is a potential p-type ferromagnet. The different dopants would induce different magnetic couplings, thus show different ground-state magnetic configurations. The mechanism for the magnetism should be useful for understanding d0 magnetic semiconductors or insulators. The present potential d0 diluted magnetic materials, at least some of them, may be useful in spintronics.

Dong, Shengjie; Zhao, Hui

2014-12-01

49

Experiments with needle bearings  

NASA Technical Reports Server (NTRS)

Experiments and results are presented in testing needle bearings, especially in comparison with roller bearings. Reduction in coefficient of friction is discussed as well as experimental methods and recording devices.

Ferretti, Pericle

1933-01-01

50

The Missing Needles: A Smooth Extension of Buffon's Needle Problem.  

ERIC Educational Resources Information Center

Describes the "Buffon's Needle" problem, which is calculating the probability that a needle will cross one of two separated lines. Calculates the probability when the length of the needle is greater than the space of the two lines. Provides an analytic solution and the results of a computer simulation. (YP)

McGivney, Raymond J., Jr.; Pollino, Benedict

1989-01-01

51

Childhood Interstitial Lung Disease  

MedlinePLUS

... growth abnormalities Neuroendocrine (noor-o-EN-do-krin) cell hyperplasia (hi-per-PLA-ze-ah) of infancy (NEHI) Pulmonary interstitial glycogenosis (gli-ko-JEN-eh-sis) Developmental disorders, such as alveolar (al-VE-o-lar) capillary dysplasia Outlook Each ...

52

ACUTE INTERSTITIAL NEPHRITIS.  

PubMed

Acute interstitial nephritis is found in the infectious diseases of children, particularly in diphtheria and scarlet fever, but may be met with in other infectious diseases. The disease is characterized by general and focal infiltration of the interstitial tissue of the kidney with cells which correspond to those which Unna has described under the name of plasma cells. The focal character of the infiltration is marked; even in the cases in which all parts of the kidney show some interstitial cellular infiltration the cells are most abundant in certain foci. These foci are found in three places: in the boundary zone of the pyramids, in the sub-capsular region of the cortex, and around the glomeruli. A considerable number of cases is found in which the blood-vessels of the boundary zone of the pyramids contain nnmbers of lymphoid and plasma cells without any infiltration of the interstitial tissue. The new cells in the interstitial tissue are due to emigration from the blood-vessels and multiplication by mitotic division of the cells which have emigrated. The cells can emigrate as plasma. cells or as lymphoid cells, and the latter may change into plasma cells in the tissues. In the normal individual, plasma cells may be formed in the mucous membrane of the intestine, where they practically form the entire tissue between the epithelium and the muscularis mucosa, and to a limited extent in the spleen. In diphtheria, in scarlet fever, and probably in a number of infectious diseases, plasma cells are formed in great numbers in the spleen and bone-marrow, and to some extent in the lymphatic glands. In the spleen they are formed from the cells of the Malpighian bodies, which are often principally composed of them, and to some extent from the cells in the pulp. They are formed from the lymphoid cells. No adequate explanation is found for the focal character of the lesions in the kidneys. There is some ground for believing that the physical conditions of the circulation may have something to do with their accumulation in the vessels in certain places. It is also possible that in the interstitial foci there may be soluble substances which exert a positive chemotaxis for them. Such substances may be foundin the urine, which may exert its influence on the interstitial tissue in different places. The explanation of the foci cannot be found in primary focal degeneration of the epithelium. Epithclial degeneration in these cases is always present, but it is diffuse. In foci where it is more intense and due to the interstitial changes, polynuclear leucocytes are found in the tissue, in the degenerated epithellum and in the tubules. Folynuclear lencocytes and not plasma cells are attracted by degenerated tissue. The foci are not due in these cases to the local action of bacteria. In a number of the cases in which interstitial nephritis was found the kidneys were shown to be sterile both by cultures and by microscopical examination. In cases where bacteria were present they were found only in small numbers in cultures and not on microscopical examination, and their connection with the foci could not be demonstrated. In three cases plasma cells were found in the interstitial tissue in definite bacterial diseases of the kidney. In these cases they were not found in connection with the lesions produced directly by the bacteria, but in the periphery of the purulent foci. PMID:19866889

Councilman, W T

1898-07-01

53

A theoretical analysis of interstitial hydrogen : pressure-composition-temperature, chemical potential, enthalpy and entropy  

E-print Network

We provide a first principles analysis of the physics and thermodynamics of interstitial hydrogen in metal. By utilizing recent advances in Density Functional Theory (DFT) to get state energies of the metal-hydrogen system, ...

Orondo, Peter Omondi

2012-01-01

54

Interstitial rotating shield brachytherapy for prostate cancer  

SciTech Connect

Purpose: To present a novel needle, catheter, and radiation source system for interstitial rotating shield brachytherapy (I-RSBT) of the prostate. I-RSBT is a promising technique for reducing urethra, rectum, and bladder dose relative to conventional interstitial high-dose-rate brachytherapy (HDR-BT). Methods: A wire-mounted 62 GBq{sup 153}Gd source is proposed with an encapsulated diameter of 0.59 mm, active diameter of 0.44 mm, and active length of 10 mm. A concept model I-RSBT needle/catheter pair was constructed using concentric 50 and 75 ?m thick nickel-titanium alloy (nitinol) tubes. The needle is 16-gauge (1.651 mm) in outer diameter and the catheter contains a 535 ?m thick platinum shield. I-RSBT and conventional HDR-BT treatment plans for a prostate cancer patient were generated based on Monte Carlo dose calculations. In order to minimize urethral dose, urethral dose gradient volumes within 0–5 mm of the urethra surface were allowed to receive doses less than the prescribed dose of 100%. Results: The platinum shield reduced the dose rate on the shielded side of the source at 1 cm off-axis to 6.4% of the dose rate on the unshielded side. For the case considered, for the same minimum dose to the hottest 98% of the clinical target volume (D{sub 98%}), I-RSBT reduced urethral D{sub 0.1cc} below that of conventional HDR-BT by 29%, 33%, 38%, and 44% for urethral dose gradient volumes within 0, 1, 3, and 5 mm of the urethra surface, respectively. Percentages are expressed relative to the prescription dose of 100%. For the case considered, for the same urethral dose gradient volumes, rectum D{sub 1cc} was reduced by 7%, 6%, 6%, and 6%, respectively, and bladder D{sub 1cc} was reduced by 4%, 5%, 5%, and 6%, respectively. Treatment time to deliver 20 Gy with I-RSBT was 154 min with ten 62 GBq {sup 153}Gd sources. Conclusions: For the case considered, the proposed{sup 153}Gd-based I-RSBT system has the potential to lower the urethral dose relative to HDR-BT by 29%–44% if the clinician allows a urethral dose gradient volume of 0–5 mm around the urethra to receive a dose below the prescription. A multisource approach is necessary in order to deliver the proposed {sup 153}Gd-based I-RSBT technique in reasonable treatment times.

Adams, Quentin E., E-mail: quentin-adams@uiowa.edu; Xu, Jinghzu; Breitbach, Elizabeth K.; Li, Xing; Rockey, William R.; Kim, Yusung; Wu, Xiaodong; Flynn, Ryan T. [Department of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242 (United States)] [Department of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242 (United States); Enger, Shirin A. [Medical Physics Unit, McGill University, 1650 Cedar Ave, Montreal, Quebec H3G 1A4 (Canada)] [Medical Physics Unit, McGill University, 1650 Cedar Ave, Montreal, Quebec H3G 1A4 (Canada)

2014-05-15

55

Mesalazine induced interstitial nephritis.  

PubMed Central

5-Aminosalicylic acid (5-ASA) has structural similarities to both phenacetin and aspirin, which are known to cause 'analgesic nephropathy'. Because of the increasing use of 5-ASA, this paper draws attention to two cases of severe interstitial nephritis resulting from 5-ASA and emphasises the importance of monitoring renal functions of patients with inflammatory bowel diseases who are receiving 5-ASA preparations. Images p1494-a PMID:7959212

Thuluvath, P J; Ninkovic, M; Calam, J; Anderson, M

1994-01-01

56

Interstitial lung disease.  

PubMed

This article reviews the most important articles published in interstitial lung disease, as reviewed during the Clinical Year in Review session at the 2012 annual European Respiratory Society Congress in Vienna, Austria. Since the recent international guidelines for the management of idiopathic pulmonary fibrosis (IPF), important new evidence is available. The anti-fibrotic drug pirfenidone has been recently approved in Europe. Other pharmacological agents, especially nintedanib, are still being tested. The so-called triple combination therapy, anticoagulation therapy and endothelin receptor antagonists, especially ambrisentan, are either harmful or ineffective in IPF and are not recommended as treatment. Although the clinical course of IPF is highly variable, novel tools have been developed for individual prediction of prognosis. Acute exacerbations of IPF are associated with increased mortality and may occur with higher frequency in IPF patients with associated pulmonary hypertension. Interstitial lung disease associated with connective tissue disease has been definitely established to have a better long-term survival than IPF. A subset of patients present with symptoms and/or biological autoimmune features, but do not fulfil diagnostic criteria for a given autoimmune disease; this condition is associated with a higher prevalence of nonspecific interstitial pneumonia pattern, female sex and younger age, although survival relevance is unclear. PMID:23457161

Cottin, Vincent

2013-03-01

57

Magnetic resonance-guided interstitial therapy for vaginal recurrence of endometrial cancer  

SciTech Connect

Purpose: To evaluate the feasibility and to describe the acute toxicity of a real-time intraoperative magnetic resonance (MR)-image guided interstitial approach to treating vaginal recurrence of endometrial cancer. Methods and Materials: From February 2004 to April 2005, 10 patients with recurrent endometrial cancer underwent MR-guided interstitial brachytherapy. Parameters evaluated included needle placement, dose-volume histograms (DVH), and complications. Results: Magnetic resonance-image guidance resulted in accurate needle placement. Tumor DVH values included median volume, 47 cc; V100, 89%; V150, 61%; V200, 38%; D90, 71 Gy; and D100, 60 Gy. DVH of organs at risk resulted in a median D2cc of external beam and brachytherapy dose (% of brachytherapy prescription): bladder, 75Gy{sub 3} (88%); rectum, 70Gy{sub 3} (87%); and sigmoid, 56Gy{sub 3} (41%). All patients experienced either a Grade 1 or 2 acute toxicity related to the radiation; only 1 patient had Grade 3 toxicity. No toxicities were attributable to the use of MR guidance. Conclusions: Real-time MR guidance during the insertion of interstitial needles reduces the likelihood of an inadvertent insertion of the needles into the bladder and the rectum. Three-dimensional dosimetry allows estimation of the dose to organs at risk. Toxicities are limited.

Viswanathan, Akila N. [Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (United States)]. E-mail: aviswanathan@partners.org; Cormack, Robert [Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (United States); Holloway, Caroline L. [Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (United States); Tanaka, Cynthia [Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (United States); O'Farrell, Desmond C. [Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (United States); Devlin, Phillip M. [Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (United States); Tempany, Clare [Department of Radiology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (United States)

2006-09-01

58

Optic fiber needle to probe inside the body using fluorescence ratio method  

NASA Astrophysics Data System (ADS)

An optical fiber needle probe was developed that can be inserted into a hollow metallic needle for tumor diagnosis using fluorescence at key wavelengths for breast, kidney, liver, and brain. The optical fiber needle probe is based on fluorescence ration method which will allow to detect tumor in vivo for a real time evaluation. This method will be couple with other current modalities such as X-ray, ultrasound and MRI.

Tang, Gui C.; Katz, Alvin; Budansky, Yury; Alfano, Robert R.

2000-07-01

59

Interstitial granulomatous dermatitis with arthritis.  

PubMed

Interstitial granulomatous dermatitis with arthritis is an uncommon disorder. In its original description, the presence of linear inflammatory indurations on the lateral aspects of the trunk (the rope sign) in association with arthritis were considered the pathognomonic clinical features. Later cases presenting with plaques and papules have been reported. Herein we describe a case of interstitial granulomatous dermatitis with arthritis without the rope sign. The present case supports the idea that interstitial granulomatous dermatitis with arthritis may have variable clinical appearances. PMID:15257555

Altaykan, Asli; Erkin, Gül; Boztepe, Gonca; Gököz, Aytaç

2004-07-01

60

Interstitial Collagen Catabolism*  

PubMed Central

Interstitial collagen mechanical and biological properties are altered by proteases that catalyze the hydrolysis of the collagen triple-helical structure. Collagenolysis is critical in development and homeostasis but also contributes to numerous pathologies. Mammalian collagenolytic enzymes include matrix metalloproteinases, cathepsin K, and neutrophil elastase, and a variety of invertebrates and pathogens possess collagenolytic enzymes. Components of the mechanism of action for the collagenolytic enzyme MMP-1 have been defined experimentally, and insights into other collagenolytic mechanisms have been provided. Ancillary biomolecules may modulate the action of collagenolytic enzymes. PMID:23430258

Fields, Gregg B.

2013-01-01

61

Needling the early universe  

NASA Technical Reports Server (NTRS)

The possibility that the whole microwave background can be produced by a bright population of pregalactic stars at a redshift of a few hundred is explored. The radiation is thermalized by a combination of amorphous silicate, amorphous carbon, graphite, and needle-shaped conducting grains which give rise to the opacity needed at wavelengths greater than 3 cm. The occurrence of distortion in a primordial microwave background spectrum due to its interaction with Population III stars and dust is investigated. The possibility of producing deviations small enough to be consistent with the best available observations, but still detectable by COBE, is considered.

Hawkins, Isabel; Wright, Edward L.

1988-01-01

62

Occupational Interstitial Lung Disease Update  

Microsoft Academic Search

Overview Occupational exposures produce a wide range of interstitial lung disorders. Occupational etiologies account for a significant portion of all interstitial lung disease (ILD), and new causes continue to be described. All of these disorders are preventable with the reduction or elimination of workplace exposure. This chapter highlights the common, persistent diseases that continue to plague workers globally, as well

Lee S. Newman

63

Handling fragile needles Artem Evdokimov  

E-print Network

Handling fragile needles Artem Evdokimov artem@xtals.org Practicing crystallographers frequently-pain ointments (to alleviate the results of endless evenings bent over the scope fishing for fragile needles) I, along its principal axis. If you have steady hands and the crystal is not excessively fragile

64

Diffusion of Interstitial Solute-Vacancy Pairs in a Dilute Alloy  

Microsoft Academic Search

It has been proposed that the diffusion of cadmium in lead, which is inconsistent with the vacancy mechanism of solute diffusion, occurs by means of an interstitial migration which is strongly correlated because of an attraction between interstitial cadmium ions and vacancies. It is plausible that cadmium, like the noble-metal solutes, should dissolve in lead by the dissociative mechanism, but

J. Wesley Miller

1969-01-01

65

Renal Medullary Interstitial Cells  

NASA Astrophysics Data System (ADS)

Renal medullary interstitial cells (RMICs) are specialized fibroblast-like cells that reside in the renal medulla among the vasa recta, the thin limbs of Henle's loop, and medullary collecting ducts. These cells are characterized by abundant lipid droplets in the cytoplasm. The lipid droplets are composed of triglycerides, cholesterol esters and free long-chain fatty acids, including arachidonic acid. RMICs are also a major site of cyclooxygenase2 (COX-2) expression, and thus a major site of COX-2 derived prostanoid biosynthesis. RMICs are also a potential target of hormones such as angiotensin II and endothelin. The RMIC COX-2 expression and the abundance of lipid droplets change with salt and water intake. These properties of RMICs are consistent with an important role of these cells in modulating physiologic and pathologic processes of the kidney.

Rao, Reena; Hao, Chuan-Ming; Breyer, Matthew D.

2007-04-01

66

Towards quantitative off-axis electron holographic mapping of the electric field around the tip of a sharp biased metallic needle  

NASA Astrophysics Data System (ADS)

We apply off-axis electron holography and Lorentz microscopy in the transmission electron microscope to map the electric field generated by a sharp biased metallic tip. A combination of experimental data and modelling provides quantitative information about the potential and the field around the tip. Close to the tip apex, we measure a maximum field intensity of 82 MV/m, corresponding to a field k factor of 2.5, in excellent agreement with theory. In order to verify the validity of the measurements, we use the inferred charge density distribution in the tip region to generate simulated phase maps and Fresnel (out-of-focus) images for comparison with experimental measurements. While the overall agreement is excellent, the simulations also highlight the presence of an unexpected astigmatic contribution to the intensity in a highly defocused Fresnel image, which is thought to result from the geometry of the applied field.

Beleggia, M.; Kasama, T.; Larson, D. J.; Kelly, T. F.; Dunin-Borkowski, R. E.; Pozzi, G.

2014-07-01

67

Gurley Dip Needle Lake Superior Model with Case  

USGS Multimedia Gallery

Also known as a Forrester's Compass or Miner's Compass, a dip (or dipping) needle is an instrument for measuring the intensity of the earth's magnetic field. It is used to locate buried or hidden metal. Manufactured by W. & L.E. Gurley, Troy, New York. Object ID: USGS-000345...

2009-07-22

68

Improved targeting device and computer navigation for accurate placement of brachytherapy needles  

SciTech Connect

Successful treatment of skull base tumors with interstitial brachytherapy requires high targeting accuracy for the brachytherapy needles to avoid harming vital anatomical structures. To enable safe placement of the needles in this area, we developed an image-based planning and navigation system for brachytherapy, which includes a custom-made mechanical positioning arm that allows rough and fine adjustment of the needle position. The fine-adjustment mechanism consists of an XYZ microstage at the base of the arm and a needle holder with two fine-adjustable inclinations. The rotation axes of the inclinations cross at the tip of the needle so that the inclinational adjustments do not interfere with the translational adjustments. A vacuum cushion and a noninvasive fixation frame are used for the head immobilization. To avoid mechanical bending of the needles due to the weight of attached tracking markers, which would be detrimental for targeting accuracy, only a single LED marker on the tail of the needle is used. An experimental phantom-based targeting study with this setup demonstrated that a positioning accuracy of 1.4 mm (rms) can be achieved. The study showed that the proposed setup allows brachytherapy needles to be easily aligned and inserted with high targeting accuracy according to a preliminary plan. The achievable accuracy is higher than if the needles are inserted manually. The proposed system can be linked to a standard afterloader and standard dosimetry planning module. The associated additional effort is reasonable for the clinical practice and therefore the proposed procedure provides a promising tool for the safe treatment of tumors in the skull base area.

Pappas, Ion P.I.; Ryan, Paul; Cossmann, Peter; Kowal, Jens; Borgeson, Blake; Caversaccio, Marco [M.E. Mueller Research Center, University of Bern, Stauffacherstr. 78, CH-3014 Bern (Switzerland); Hirslanden Klinik Aarau, Department of Radiation Oncology, Rain 34, CH-5000 Aarau (Switzerland); M.E. Mueller Research Center, University of Bern, Stauffacherstr. 78, CH-3014 Bern (Switzerland); Inselspital, Department of ORL, Head and Neck Surgery, University of Bern, CH-3010 Bern (Switzerland)

2005-06-15

69

Explicit studies of the quantum theory of light interstitial diffusion  

Microsoft Academic Search

The formalism associated with small-polaron diffusion in the high temperature semiclassical regime is generalized so as to transcend simplifications employed in developing the nonadiabatic theory. The diffusion constant is then calculated for simple models in which the metal atoms interact with each other and with the interstitial atom with two-body forces. Studies of these models not only confirm the necessity

D. Emin; M. I. Baskes; W. D. Wilson

1978-01-01

70

Statistical thermodynamics of order-disorder in interstitial alloys  

NASA Astrophysics Data System (ADS)

A recent theory of order-disorder in alloys (Gokcen and Chang, 1971) (Gokcen, 1983) is modified for application to interstitial solutions of metalloids in metals. The results show that a single exchange energy is sufficient for the interpretation of experimental results for each system. The existing experimental data are presented and discussed. New areas of research are emphasized.

Gokcen, N. A.

71

Interstitial Lung Disease (ILD): Treatment  

MedlinePLUS

... MS Dept. of Medicine View full profile Interstitial Lung Disease (ILD): Treatment Treatment for ILD is based ... performance, improving emotional well being and reducing hospitalizations. Lung Transplant If other therapies fail to adequately treat ...

72

The ACUSITT ultrasonic ablator: the first steerable needle with an integrated interventional tool  

NASA Astrophysics Data System (ADS)

Steerability in percutaneous medical devices is highly desirable, enabling a needle or needle-like instrument to avoid sensitive structures (e.g. nerves or blood vessels), access obstructed anatomical targets, and compensate for the inevitable errors induced by registration accuracy thresholds and tissue deformation during insertion. Thus, mechanisms for needle steering have been of great interest in the engineering community in the past few years, and several have been proposed. While many interventional applications have been hypothesized for steerable needles (essentially anything deliverable via a regular needle), none have yet been demonstrated as far as the authors are aware. Instead, prior studies have focused on model validation, control, and accuracy assessment. In this paper, we present the first integrated steerable needle-interventional device. The ACUSITT integrates a multi-tube steerable Active Cannula (AC) with an Ultrasonic Interstitial Thermal Therapy ablator (USITT) to create a steerable percutaneous device that can deliver a spatially and temporally controllable (both mechanically and electronically) thermal dose profile. We present our initial experiments toward applying the ACUSITT to treat large liver tumors through a single entry point. This involves repositioning the ablator tip to several different locations, without withdrawing it from the liver capsule, under 3D Ultrasound image guidance. In our experiments, the ACUSITT was deployed to three positions, each 2cm apart in a conical pattern to demonstrate the feasibility of ablating large liver tumors 7cm in diameter without multiple parenchyma punctures.

Burdette, E. Clif; Rucker, D. Caleb; Prakash, Punit; Diederich, Chris J.; Croom, Jordon M.; Clarke, Clyde; Stolka, Philipp; Juang, Titania; Boctor, Emad M.; Webster, Robert J., III

2010-03-01

73

On-line monitoring of multi-component strain development in a tufting needle using optical fibre Bragg grating sensors  

NASA Astrophysics Data System (ADS)

Dynamic loadings induced on a tufting needle during the tufting of dry carbon fibre preform via a commercial robot-controlled tufting head were investigated in situ and in real-time using optical fibre Bragg grating (FBG) sensors bonded to the needle shaft. The sensors were configured such that the axial strain and bending moments experienced by the needle could be measured. A study of the influence of thread and thread type on the strain imparted to the needle revealed axial strain profiles which had equivalent trends but different magnitudes. The mean of the maximum axial compression strains measured during the tufting of a 4-ply quasi-isotropic carbon fibre dry preform were - 499 ± 79 ??, - 463 ± 51 ?? and - 431 ± 59 ?? for a needle without thread, with metal wire and with Kevlar® thread, respectively. The needle similarly exhibited bending moments of different magnitude when the different needle feeding configurations were used.

Chehura, Edmon; Dell'Anno, Giuseppe; Huet, Tristan; Staines, Stephen; James, Stephen W.; Partridge, Ivana K.; Tatam, Ralph P.

2014-07-01

74

Interstitial impurity-induced magnetism in ?-PbO surface  

NASA Astrophysics Data System (ADS)

We have investigated the effects of 3d transition metal (TM) and non-magnetic interstitial impurities in ?-PbO (0?0?1) surface using ab-initio calculations. The calculated impurity-induced magnetic moments are 2.25 ?B, 3.11 ?B and 0.94 ?B for Fe, Mn and Pb interstitials respectively. In the bonding process, TM's lower energy lying dz2 states form overlaps with nearest neighbour oxygen atoms' pz states, with other non-bonding spin split d states situated near or at the Fermi level. These spin split orbitals introduce spin polarised p impurity states of oxygen atoms near the surface.

Arguelles, E.; Amino, S.; Aspera, S.; Nakanishi, H.; Kasai, H.

2015-01-01

75

Fabrication of tungsten wire needles  

SciTech Connect

Fine point needles for field emissoin are conventionally produced by electrolytically or chemically etching tungsten wire. Points formed in this manner have a typical tip radius of about 0.5 microns and a cone angle of some 30 degrees. The construction of needle matrix detector chambers has created a need for tungsten needles whose specifications are: 20 mil tungsten wire, 1.5 inch total length, 3 mm-long taper (resulting in a cone angle of about 5 degrees), and 25 micron-radius point (similar to that found on sewing needles). In the process described here for producing such needles, tungsten wire, immersed in a NaOH solution and in the presence of an electrode, is connected first to an ac voltage and then to a dc supply, to form a taper and a point on the end of the wire immersed in the solution. The process parameters described here are for needles that will meet the above specifications. Possible variations will be discussed under each approprite heading.

Roder, A.

1983-02-01

76

Drug Induced Interstitial Lung Disease  

PubMed Central

With an increasing number of therapeutic drugs, the list of drugs that is responsible for severe pulmonary disease also grows. Many drugs have been associated with pulmonary complications of various types, including interstitial inflammation and fibrosis, bronchospasm, pulmonary edema, and pleural effusions. Drug-induced interstitial lung disease (DILD) can be caused by chemotherapeutic agents, antibiotics, antiarrhythmic drugs, and immunosuppressive agents. There are no distinct physiologic, radiographic or pathologic patterns of DILD, and the diagnosis is usually made when a patient with interstitial lung disease (ILD) is exposed to a medication known to result in lung disease. Other causes of ILD must be excluded. Treatment is avoidance of further exposure and systemic corticosteroids in patients with progressive or disabling disease. PMID:22896776

Schwaiblmair, Martin; Behr, Werner; Haeckel, Thomas; Märkl, Bruno; Foerg, Wolfgang; Berghaus, Thomas

2012-01-01

77

Implementation of 3D-virtual brachytherapy in the management of breast cancer: A description of a new method of interstitial brachytherapy  

Microsoft Academic Search

Purpose: We present the initial description of a new technique of interstitial breast brachytherapy in which a computer-generated image of an implant template is applied virtually to serial-computed tomography (CT) scan images of a patient's breast. Optimal placement of the virtual template around the CT images of the proposed target volume provides the physician with a preplan needles around the

Frank A. Vicini; David A. Jaffray; Eric M. Horwitz; Gregory K. Edmundson; David A. DeBiose; Vijay R. Kini; Alvaro A. Martinez

1998-01-01

78

Interstitial nephritis. A brief review.  

PubMed Central

Interstitial nephritis is a common condition, which in spite of a relatively constant pathologic picture has different etiologic agents and pathogenetic mechanisms. Failure to appreciate this, particularly in the chronic group, has led to considerable confusion and has been largely responsible for the overdiagnosis of chronic pyelonephritis. Although we are still largely ignorant of the causes of interstitial nephritis, it is now possible to define many of them. While experimental studies have not made spectacular contributions to our understanding, an attempt is now being made to develop appropriate models, and we hope these will enable us to still further clarify our understanding of other entities. PMID:776003

Heptinstall, R. H.

1976-01-01

79

Does Needle Rotation Improve Lesion Targeting?  

PubMed Central

Background Image-guided robots are manipulators that operate based on medical images. Perhaps the most common class of image-guided robots are robots for needle interventions. Typically, these robots actively position and/or orient a needle guide, but needle insertion is still done by the physician. While this arrangement may have safety advantages and keep the physician in control of needle insertion, actuated needle drivers can incorporate other useful features. Methods We first present a new needle driver that can actively insert and rotate a needle. With this device we investigate the use of needle rotation in controlled in-vitro experiments performed with a specially developed revolving needle driver. Results These experiments show that needle rotation can improve targeting and may reduce errors by as much as 70%. Conclusion The new needle driver provides a unique kinematic architecture that enables insertion with a compact mechanism. Perhaps the most interesting conclusion of the study is that lesions of soft tissue organs may not be perfectly targeted with a needle without using special techniques, either manually or with a robotic device. The results of this study show that needle rotation may be an effective method of reducing targeting errors. PMID:21360796

Badaan, Shadi; Petrisor, Doru; Kim, Chunwoo; Mozer, Pierre; Mazilu, Dumitru; Gruionu, Lucian; Patriciu, Alex; Cleary, Kevin; Stoianovici, Dan

2011-01-01

80

How Is Childhood Interstitial Lung Disease Treated?  

MedlinePLUS

... the NHLBI on Twitter. How Is Childhood Interstitial Lung Disease Treated? Childhood interstitial lung disease (chILD) is ... prevent acid reflux, which can lead to aspiration. Lung Transplant A lung transplant may be an option ...

81

Types of Childhood Interstitial Lung Disease  

MedlinePLUS

... the NHLBI on Twitter. Types of Childhood Interstitial Lung Disease The broad term "childhood interstitial lung disease" ( ... affect are shown in the illustration below. Normal Lungs and Lung Structures Figure A shows the location ...

82

21 CFR 880.5580 - Acupuncture needle.  

Code of Federal Regulations, 2010 CFR

...Identification. An acupuncture needle is a device intended to pierce the skin in the practice of acupuncture. The device consists...needle to facilitate the delivery of acupuncture treatment. (b) Classification. Class II (special controls)....

2010-04-01

83

Secure Container For Discarded Hypodermic Needles  

NASA Technical Reports Server (NTRS)

Container designed for safe retention of discarded blood-collecting hypodermic needles and similar sharp objects used in life-science experiments aboard spacecraft. Needles inserted through self-closing lid and retained magnetically. They are inserted, sharp end first, through spring-loaded flap. Long needles and needles on syringes cannot turn around in container. Can be emptied, cleaned, and reused. Used on Earth to provide unusually secure containment of sharp objects.

Lee, Angelene M.

1992-01-01

84

Interstitial Vascularity in Fibrosing Alveolitis  

Microsoft Academic Search

The aim of this study was to evaluate interstitial vascularity in crypto- humoral autoimmunity, is often associated with lung involve- genic fibrosing alveolitis (CFA) and in fibrosing alveolitis associated ment. Vascular involvement in SSc is exemplified by the with systemic sclerosis (FASSc). Open lung biopsies from eight pa- typical changes of nailfold capillaries, which include enlarged tients with CFA, nine

Elisabetta A. Renzoni; David A. Walsh; Michael Salmon; Athol U. Wells; Andrew G. Nicholson; Srihari Veeraraghavan; Anne E. Bishop; Hanna M. Romanska; Panagiotis Pantelidis; Carol M. Black

2003-01-01

85

Dormant Microbes in Interstitial Cystitis  

Microsoft Academic Search

Interstitial cystitis (IC) is an inflammatory disease of the urinary bladder that has no known etiology. A microbial association with this disease has not been supported since routine cultures of urine from IC patients are usually negative. However, we have demonstrated the presence of bacterial 16S rRNA genes in bladder biopsies from 29 percent of patients with IC, but not

Gerald J. Domingue; Gamal M. Ghoniem; Kenneth L. Bost; Cesar Fermin; Liset G. Human

1995-01-01

86

The diagnosis of interstitial cystitis.  

PubMed

The diagnosis of interstitial cystitis can be firmly established by evaluating symptoms and history carefully, ruling out other diseases which can mimic its clinical picture, and performing the necessary cystoscopic examination (almost always under anesthesia). We also advocate that biopsy be performed in all individuals; although, since no pathognomonic abnormalities are demonstrable, it is unclear if the diagnosis of interstitial cystitis can be established or excluded by biopsy alone (unless, of course, another disease is encountered). While urodynamic studies are primarily useful to rule out interstitial cystitis, they may, in addition, have a role in subsequent management and/or in assessment of therapeutic response and thus, at least simple cystometry should probably also be performed. However, more complex urodynamic (e.g., electromyography, urethral pressure profilometry, etc.), radiographic (e.g., intravenous urography, voiding cystourethrography, or computerized axial tomography), laboratory or surgical (e.g., laparoscopy, prostate biopsy) studies are of minimal value in diagnosing interstitial cystitis and should only be done in the face of clinical evidence indicating their appropriateness. PMID:3564233

Messing, E M

1987-04-01

87

MRI-guided prostate focal laser ablation therapy using a mechatronic needle guidance system  

NASA Astrophysics Data System (ADS)

Focal therapy of localized prostate cancer is receiving increased attention due to its potential for providing effective cancer control in select patients with minimal treatment-related side effects. Magnetic resonance imaging (MRI)-guided focal laser ablation (FLA) therapy is an attractive modality for such an approach. In FLA therapy, accurate placement of laser fibers is critical to ensuring that the full target volume is ablated. In practice, error in needle placement is invariably present due to pre- to intra-procedure image registration error, needle deflection, prostate motion, and variability in interventionalist skill. In addition, some of these sources of error are difficult to control, since the available workspace and patient positions are restricted within a clinical MRI bore. In an attempt to take full advantage of the utility of intraprocedure MRI, while minimizing error in needle placement, we developed an MRI-compatible mechatronic system for guiding needles to the prostate for FLA therapy. The system has been used to place interstitial catheters for MRI-guided FLA therapy in eight subjects in an ongoing Phase I/II clinical trial. Data from these cases has provided quantification of the level of uncertainty in needle placement error. To relate needle placement error to clinical outcome, we developed a model for predicting the probability of achieving complete focal target ablation for a family of parameterized treatment plans. Results from this work have enabled the specification of evidence-based selection criteria for the maximum target size that can be confidently ablated using this technique, and quantify the benefit that may be gained with improvements in needle placement accuracy.

Cepek, Jeremy; Lindner, Uri; Ghai, Sangeet; Davidson, Sean R. H.; Trachtenberg, John; Fenster, Aaron

2014-03-01

88

Finding a needle in the common carotid artery 3 years after ingestion.  

PubMed

A woman presented with an ischemic stroke involving the right middle cerebral artery. Investigations revealed a foreign body in the cervical area. It was identified as a metal needle, perforating the posterior pharyngeal wall and migrating into the right common carotid artery (CCA). Three years previously, this patient had complained of odynophagia, brought on by needle ingestion. Three days before her stroke, she had hematemesis, caused by migration of the needle into the CCA. The stroke was caused by migration of the thrombus. This type of event is rarely encountered in Europe. Early recognition could avoid dangerous vascular complications. PMID:24447848

Gaudin, Marie; Couchet, Geoffroy; Carrieres, Caroline; Ribal, Jean-Pierre; Rosset, Eugenio

2014-07-01

89

`Smart' Needle for Percutaneous Surgery: Influential Factor Investigation  

Microsoft Academic Search

Precise needle insertion is important for a number of percutaneous interventions. Yet it is difficult to achieve in practice due to target movement and needle deflection. Preliminary design and simulation of 'Smart Needle' are presented in this paper for active needle steering. This smart needle is designed to use piezoelectric actuators to adjust the needle tip position. Some simulations have

Kaiguo Yan; Tarun Podder; Wan Sing Ng; Yan Yu

2007-01-01

90

Red needles signify dying pines  

USGS Multimedia Gallery

Reddish, dry needles are a sign of dying trees infested with mountain pine beetles.  Mountain pine beetle outbreaks can result in the loss of millions of pine trees throughout western North America. The beetles lay eggs and develop in the bark of mountain trees, especially lodgepole, ponderosa...

91

Combined spinal-epidural needle  

Microsoft Academic Search

subcutaneously using a 25-gauge needle alongside the epidural catheter. The epidural catheter was removed an hour later without further complications. We prefer to leave the epidural catheter in place during persistent bleeding from the epidural site. The catheter may tamponade the punctured vessel and help to identify the site of the traumatized vessel. We do not think it is necessary

Alberto Torrieri; J. Antonio Aldrete

1989-01-01

92

COMPARISONS OF NEEDLE INSERTION IN  

E-print Network

: France (2007)" #12;PROSTATE BRACHYTHERAPY Prostate cancer is nowadays the most diagnosed cancer among men at comparing the results of different prostate brachytherapy protocols concerning needle insertion order and its influence on tissue deformations. Prostate brachytherapy consists in the insertion of radioactive

Paris-Sud XI, Université de

93

Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method  

PubMed Central

Laser immunotherapy (LIT) uses a synergistic approach to treat cancer systemically through local laser irradiation and immunological stimulation. Currently, LIT utilizes dye-assisted noninvasive laser irradiation to achieve selective photothermal interaction. However, LIT faces difficulties treating deeper tumors or tumors with heavily pigmented overlying skin. To circumvent these barriers, we use interstitial laser irradiation to induce the desired photothermal effects. The purpose of this study is to analyze the thermal effects of interstitial irradiation using proton resonance frequency (PRF). An 805-nm near-infrared laser with an interstitial cylindrical diffuser was used to treat rat mammary tumors. Different power settings (1.0, 1.25, and 1.5 W) were applied with an irradiation duration of 10 min. The temperature distributions of the treated tumors were measured by a 7 T magnetic resonance imager using PRF. We found that temperature distributions in tissue depended on both laser power and time settings, and that variance in tissue composition has a major influence in temperature elevation. The temperature elevations measured during interstitial laser irradiation by PRF and thermocouple were consistent, with some variations due to tissue composition and the positioning of the thermocouple's needle probes. Our results indicated that, for a tissue irradiation of 10 min, the elevation of rat tumor temperature ranged from 8 to 11°C for 1 W and 8 to 15°C for 1.5 W. This is the first time a 7 T magnetic resonance imager has been used to monitor interstitial laser irradiation via PRF. Our work provides a basic understanding of the photothermal interaction needed to control the thermal damage inside a tumor using interstitial laser treatment. Our work may lead to an optimal protocol for future cancer treatment using interstitial phototherapy in conjunction with immunotherapy. PMID:22191937

Le, Kelvin; Li, Xiaosong; Figueroa, Daniel; Towner, Rheal A.; Garteiser, Philippe; Saunders, Debra; Smith, Nataliya; Liu, Hong; Hode, Tomas; Nordquist, Robert E.; Chen, Wei R.

2011-01-01

94

Diffusion of hydrogen and its isotopes in BCC metals  

Microsoft Academic Search

The diffusion constant for models of the interatomic interatomic interactions associated with an interstitial in a metal were calculated. With this procedure the conditions under which quantum-mechanical tunneling is the predominant mode of light interstitial transport in metals was investigated. In situtations characterized by interstitial tunneling motion the validity of simplifying assumptions of the formal theory were examined. There are

D. Emin; M. I. Baskes; W. D. Wilson

1979-01-01

95

Interstitial microwave hyperthermia treatment investigations  

NASA Astrophysics Data System (ADS)

Microwave ablation also called interstitial hyperthermia is a medical procedure used in the treatment of many cancers, cardiac arrhythmias and other medical conditions. With this medical therapy, an electromagnetic source (antenna) is directly positioned in the target tissue and a sufficient power is injected to necrosis the tissue. The aim of this study is to propose a design procedure and develop the associated tools, for determining the optimal shape, dimensions, type and operating frequency of antenna according to the target volume. In this context, a 3D numerical predictive model of temperature elevation induced by the electric fields and two benches for thermal and electrical tissues properties characterization have been developed. To validate the procedure and the different tools, an experimental bench test which includes interstitial antenna, external microwave generator, phantom that represents the target tissue and measurement system of temperature and electric field has been elaborated.

Siauve, N.; Lormel, C.

2012-11-01

96

The dynamics of dislocation interaction with sessile self-interstitial atom (SIA) defect cluster atmospheres  

E-print Network

to that of unirradiated BCC metals containing impurities. At some critical irradiation dose (e.g. $0.1 dpa in Cu dislocations and radiation induced sessile self-interstitial atom (SIA) dislocation loops in FCC metals the critical stress to free trapped dislocations from pinning atmospheres (i.e. the critical resolved shear

Ghoniem, Nasr M.

97

Quality Assurance of Multifractionated Pelvic Interstitial Brachytherapy for Postoperative Recurrences of Cervical Cancers: A Prospective Study  

SciTech Connect

Purpose: To evaluate three-dimensional needle displacements during multifractionated interstitial brachytherapy (BT) for cervical cancers. Methods and Materials: Patients scheduled to undergo pelvic interstitial BT for postoperative and or postradiation vault recurrences were included from November 2009 to December 2010. All procedures were performed under spinal anesthesia. Postprocedure BT planning CT scans were obtained with patients in supine position with arms on the chest (interslice thickness of 3 mm). Thereafter, verification CT was repeated at every alternate fraction. Needle displacements were measured in reference to a relocatable bony point. The mean cranial, caudal, anteroposterior, and mediolateral displacements were recorded. Statistical significance of mean interfraction displacements was evaluated with Wilcoxon Test. Results: Twenty patients were included. Seventeen received boost BT (20 Gy/5 fractions/3 days) after external radiation, three received radical BT alone (36 Gy/9 fractions/5-8 days). An average of three scans (range, 2-3) were available per patient, and 357 needle displacements were analyzed. For the entire study cohort, the average of mean needle displacement was 2.5 mm (range, 0-7.4), 17.4 mm (range, 0-27.9), 1.7 mm (range, 0-6.7), 2.1 mm (range, 0-9.5), 1.7 mm (range, 0-9.3), and 0.6 mm (range, 0-7.8) in cranial, caudal, anterior, posterior, right, and left directions, respectively. The mean displacement in the caudal direction was higher between Days 1 and 2 than that between Days 2 and 3 (13.4 mm vs. 3.8 mm; p = 0.01). The average caudal displacements were no different between reirradiation and boost cohort (15.2 vs. 17.8 mm). Conclusions: Clinically significant caudal displacements occur during multifractionated pelvic brachytherapy. Optimal margins need to be incorporated while preplanning brachytherapy to account for interfraction displacements.

Shukla, Pragya [Department of Radiation Oncology and Medical Physics, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, Maharashtra (India); Chopra, Supriya, E-mail: schopra@actrec.gov.in [Department of Radiation Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Mumbai, Maharashtra (India); Engineer, Reena; Mahantshetty, Umesh [Department of Radiation Oncology and Medical Physics, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, Maharashtra (India); Paul, Siji Nojin; Phurailatpam, Reena [Department of Radiation Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Mumbai, Maharashtra (India); SV, Jamema; Shrivastava, Shyam K. [Department of Radiation Oncology and Medical Physics, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, Maharashtra (India)

2012-03-15

98

Contaminated marine sediments: Water column and interstitial toxic effects  

SciTech Connect

The toxicity that contaminated sediments may introduce into the water column has not been measured extensively. In order to quantify this potential toxicity, the seawater overlying two uncontaminated and three contaminated marine sediments was evaluated in the laboratory with the sea urchin Arbacia punctulata fertilization test. Concentration of polychlorinated biphenyls (PCBs) and copper, as representative contaminants, were also measured. To characterize sources of toxicity, samples were chemically manipulated using reversed-phase chromatography, cation exchange, and chelation. Water column toxicity and contaminant concentrations were higher in the suspended exposures than in bedded exposures. Interstitial water toxicity and contaminant concentrations were generally greater than either bedded or suspended exposures. Chemical manipulation indicated that the observed toxicity in water column exposures was probably caused by metallic and/or nonionic organic contaminants. Conversely, manipulation of interstitial water did not result in significantly reduced toxicity, suggesting that other toxicants such as ammonia and hydrogen sulfide may be active.

Burgess, R.M.; McKinney, R.A. (Science Applications International Corp., Narragansett, RI (United States)); Schweitzer, K.A. (Chemical Waste Management, Inc., Dartmouth, MA (United States)); Phelps, D.K. (Environmental Protection Agency, Narragansett, RI (United States))

1993-01-01

99

Contaminated marine sediments: Water column and interstitial toxic effects  

SciTech Connect

The toxicity that contaminated sediments may introduce into the water column has not been measured extensively. In order to quantify this potential toxicity, the seawater overlying two uncontaminated and three contaminated marine sediments was evaluated in the laboratory with the sea urchin Arbacia punctulata fertilization test. Concentrations of polychlorinated biphenyls (PCBs) and copper, as representative contaminants, were also measured. To characterize sources of toxicity, samples were chemically manipulated using reversed-phase chromatography, cation exchange, and chelation. Water column toxicity and contaminant concentrations were higher in the suspended exposures than in bedded exposures. Interstitial water toxicity and contaminant concentrations were generally greater than either bedded or suspended exposures. Chemical manipulation indicated that the observed toxicity in water column exposures was probably caused by metallic and/or nonionic organic contaminants. Conversely, manipulation of interstitial waters did not result in significantly reduced toxicity, suggesting that other toxicants such as ammonia and hydrogen sulfide may be active.

Burgess, R.M.; Schweitzer, K.A.; McKinney, R.A.; Phelps, D.K.

1993-01-01

100

Modeling and Control of Needles With Torsional Friction  

Microsoft Academic Search

A flexible needle can be accurately steered by robotically controlling the bevel tip orientation as the needle is inserted into tissue. Friction between the long, flexible needle shaft and the tissue can cause a significant discrepancy between the orientation of the needle tip and the orientation of the base where the needle angle is controlled. Our experiments show that several

Allison M. Okamura; Noah J. Cowan

2009-01-01

101

Chondroitin sulfate for interstitial cystitis.  

PubMed

(1) Chondroitin sulfate solution 2.0% is a glycosaminoglycan (GAG) replenishment therapy instilled into the bladder of GAG-deficient patients with interstitial cystitis (IC). (2) Two non-randomized, uncontrolled pilot studies report improvements in patient-reported symptoms after the use of chondroitin sulfate for one year. Prospective, randomized, head-to-head trials are needed to assess the effectiveness of this technology compared with other IC therapies. (3) The cost and demand for this technology are low, but there could be a significant impact on clinics that administer treatment, if uptake increases. PMID:16724430

Palylyk-Colwell, E

2006-05-01

102

Internal friction peaks due to interstitials in bcc alloys  

SciTech Connect

Richter's and Snoek's original works established the existence of an anelastic relaxation produced by a stress-induced interstitial reorientation in bcc metals. This anelastic relaxation, now referred to as a Snoek peak, has been studied extensively and well characterized in the past for the interstitials carbon, nitrogen, and oxygen. The existence of a hydrogen Snoek peak in bcc metals has been a matter of some controversy, however. We have studied relaxation peaks in V, Nb, and V-Nb alloys recently. The alloys have complete mutual solubility and are of interest since they have an extremely high room temperature solid solubility for hydrogen. They also have, over a certain composition range, not shown any hydride phase precipitation at temperatures as low as 4K. Thus, if a hydrogen Snoek peak does exist, it should be found in such alloys. Indeed there is evidence now of a spectrum of hydrogen relaxation peaks below room temperature. Furthermore, there is a large misfit of V in Nb and Nb in V and, possibly, some chemical interaction such that trapping (or antitrapping) of the interstitials at the substitutional sites, causing solute-interstitial peaks, can be characterized. The present paper provides an overview of our observations regarding: the effect of hydrogen on the oxygen and nitrogen Snoek peaks in pure V and Nb, The oxygen relaxation peaks in V-Nb alloys, The hydrogen relaxation spectrum in V-Nb alloys, and the effect of oxygen on the hydrogen relaxation spectrum in V-Nb alloys. 52 refs., 13 figs., 3 tabs.

Buck, O.; Carlson, O.N.; Indrawirawan, H.; Brasche, L.J.H.; Peterson, D.T.

1991-01-01

103

Technical Note: Comparison of traditional needle vaccination to pneumatic, needle-free vaccination in sheep  

Technology Transfer Automated Retrieval System (TEKTRAN)

Lateral transmission of blood-borne diseases can occur when a single needle is used repeatedly to vaccinate livestock. Needle-free technology to vaccinate sheep without damaging the carcass, causing lesions, and/or leaving needle fragments, and eliciting a similar antibody response to traditional n...

104

A subcutaneous Raman needle probe.  

PubMed

Raman spectroscopy is a powerful tool for studying the biochemical composition of tissues and cells in the human body. We describe the initial results of a feasibility study to design and build a miniature, fiber optic probe incorporated into a standard hypodermic needle. This probe is intended for use in optical biopsies of solid tissues to provide valuable information of disease type, such as in the lymphatic system, breast, or prostate, or of such tissue types as muscle, fat, or spinal, when identifying a critical injection site. The optical design and fabrication of this probe is described, and example spectra of various ex vivo samples are shown. PMID:23452501

Day, John C C; Stone, Nicholas

2013-03-01

105

21 CFR 880.6920 - Syringe needle introducer.  

Code of Federal Regulations, 2010 CFR

...needle introducer. (a) Identification. A syringe needle introducer is a device that uses a spring-loaded mechanism to drive a hypodermic needle into a patient to a predetermined depth below the skin surface. (b) Classification....

2010-04-01

106

21 CFR 880.5570 - Hypodermic single lumen needle.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 false Hypodermic single lumen needle. 880.5570 Section 880.5570...Devices § 880.5570 Hypodermic single lumen needle. (a) Identification. A hypodermic single lumen needle is a device intended to...

2010-04-01

107

21 CFR 868.5150 - Anesthesia conduction needle.  

...2014-04-01 2014-04-01 false Anesthesia conduction needle. 868.5150 ...Therapeutic Devices § 868.5150 Anesthesia conduction needle. (a) Identification. An anesthesia conduction needle is a device...

2014-04-01

108

21 CFR 868.5150 - Anesthesia conduction needle.  

Code of Federal Regulations, 2011 CFR

...2011-04-01 2011-04-01 false Anesthesia conduction needle. 868.5150 ...Therapeutic Devices § 868.5150 Anesthesia conduction needle. (a) Identification. An anesthesia conduction needle is a device...

2011-04-01

109

21 CFR 868.5150 - Anesthesia conduction needle.  

Code of Federal Regulations, 2013 CFR

...2013-04-01 2013-04-01 false Anesthesia conduction needle. 868.5150 ...Therapeutic Devices § 868.5150 Anesthesia conduction needle. (a) Identification. An anesthesia conduction needle is a device...

2013-04-01

110

21 CFR 868.5150 - Anesthesia conduction needle.  

Code of Federal Regulations, 2012 CFR

...2012-04-01 2012-04-01 false Anesthesia conduction needle. 868.5150 ...Therapeutic Devices § 868.5150 Anesthesia conduction needle. (a) Identification. An anesthesia conduction needle is a device...

2012-04-01

111

21 CFR 868.5150 - Anesthesia conduction needle.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 2010-04-01 false Anesthesia conduction needle. 868.5150 ...Therapeutic Devices § 868.5150 Anesthesia conduction needle. (a) Identification. An anesthesia conduction needle is a device...

2010-04-01

112

Dicliques: Finding Needles in Haystacks  

NASA Astrophysics Data System (ADS)

A key task in counterterrorism is finding useful records and combinations of records in very large heterogeneous databases. The bits and pieces of information come from many sources and the pieces do not all tightly connect together. Some (possibly disconnected) pieces tightly connect to some other (possibly disconnected) pieces. The databases are very large and the number of records that pertain to terrorist activity is very small. The problem is to find a needle in a haystack, that involves connections between different types of relevant data. This chapter describes the mathematical properties of the diclique structure, which encodes a key concept of what such meaningful ‘needles’ may look like. We show that the set of dicliques forms a lattice and in two different ways forms commutative idempotent monoids. By investigating groupoid homomorphisms on the monoid structure, we show how to coalesce overlapping dicliques and how coalesing a pair of dicliques may require coalescing other dicliques. These results point towards useful new data mining tools.

Haralick, Robert M.

113

SOLIST or How To Look For a Needle in a Haystack? A Lightweight Multi-Overlay Structure for Wireless Sensor Networks  

E-print Network

SOLIST or How To Look For a Needle in a Haystack? A Lightweight Multi-Overlay Structure as searching a needle in a haystack without any metal detector. The most natural way to explore the network of SOLIST (Self-Organized Large-scale and lightweight Information-based Sensor Technology), a structured

Paris-Sud XI, Université de

114

Modeling of interstitial branching of axonal networks.  

PubMed

A mathematical model is developed to describe and investigate interstitial branching of axonal networks during nervous system development. The model under consideration describes axonal network growth in which the concentration of axon guidance molecules controls axon's growth and interstitial branching from axon shaft. Numerical simulations show that in the model framework axonal networks branch similarly to real neural networks in vitro. PMID:23621460

Suleymanov, Y; Gafarov, F; Khusnutdinov, N

2013-03-01

115

[Interstitial lung diseases. The pattern is important].  

PubMed

Interstitial lung diseases (ILDs) comprise a number of rare entities with an estimated incidence of 10-25 per 100,000 inhabitants but the incidence greatly increases beyond the age of 65 years. The prognosis depends on the underlying cause. The fibrotic disorders show a set of radiological and histopathological patterns that are distinct but not entirely specific. In the absence of a clear clinical picture and consistent high resolution computed tomography (HRCT) findings, patients are advised to undergo surgical lung biopsies from two or three lung lobes (or transbronchial biopsies) to determine the histopathological pattern. The ILDs are differentiated into disorders of known causes (e.g. collagen vascular disease, drug-related), idiopathic interstitial pneumonia (IIP), granulomatous ILDs (e.g. sarcoidosis) and other forms of ILD (e.g. Langerhans' cell histiocytosis). The IIPs encompass idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia, desquamative interstitial pneumonia, respiratory bronchiolitis-interstitial lung disease, cryptogen organizing pneumonia, lymphocytic interstitial pneumonia and acute interstitial pneumonia. Additionally, a category of unclassified interstitial pneumonia exists. The pathologist has to recognize and address the histopathological pattern. In a multidisciplinary discussion the disorder is allocated to a clinicopathological entity and the histopathological pattern plays a major role in the classification of the entity. Recognition of the underlying pattern and the respective histopathological differential diagnoses is important as the therapy varies depending on the cause and ranges from elimination of the stimulus (if possible) to antifibrotic drug therapy up to preparation for lung transplantation. PMID:25319226

Fink, L

2014-11-01

116

Resistance forces acting on suture needles.  

PubMed

Understanding the resistance forces encountered by a suture needle during tissue penetration is important for the development of robotic surgical devices and virtual reality surgical simulators. Tensile forces applied to skin and tendon during suturing were measured. Fresh sheep achilles tendons were tensioned with a static load 4.9 N, 9.8 N or 19.6 N and sheepskin with 0.98 N, 2.9 N or 4.9 N static load. A straight 2/0 cutting suture needle in series with a load cell on a materials testing machine penetrated the tissue at 90 degrees with a velocity of 1, 5 or 10mm/s for each tissue tension (n=5). Continuous load versus displacement data was obtained and penetration load and stiffness were noted. The load versus displacement curve for skin during needle penetration demonstrated two characteristic peaks, corresponding to initial penetration and emergence of needle from the undersurface of the tissue. Increasing the tension within the tissue (skin and tendon) increased the amount of force required to penetrate the tissue with a suture needle (p<0.05). Needle displacement rate did not affect the resistance to needle penetration (p<0.05). This study provides a simple model for measuring force-feedback during needle penetration of soft tissues and is a good starting point for future studies of the penetration resistance properties of human tissues. PMID:11522313

Frick, T B; Marucci, D D; Cartmill, J A; Martin, C J; Walsh, W R

2001-10-01

117

Transbronchial needle aspiration in clinical practice  

Microsoft Academic Search

Transbronchial needle aspiration has recently been adapted for use with the flexible bronchoscope. We studied 108 patients, who had a total of 110 aspirations performed, and diagnosed thoracic cancer in 70 cases. Transbronchial needle aspiration revealed malignant disease in 32 (46%) of these 70 patients. In 12 (17%) patients with cancer this technique provided the sole cytological or histological confirmation

E M Harrow; F A Oldenburg; A M Smith

1985-01-01

118

Needle Exchange Programs and Drug Injection Behavior  

ERIC Educational Resources Information Center

This study examines how drug injection and needle sharing propensities respond when a needle exchange program (NEP) is introduced into a city. I analyze 1989-1995 Drug Use Forecasting data on adult male arrestees from 24 large U.S. cities, in nine of which NEPs opened during the sample period. After controlling for cocaine and heroin prices, AIDS…

DeSimone, Jeff

2005-01-01

119

Acne scarring treatment using skin needling  

Microsoft Academic Search

Background. Acne is a common condition seen in up to 80% of people between 11 and 30 years of age and in up to 5% of older adults. In some patients, it can result in permanent scars that are surprisingly difficult to treat. A relatively new treatment, termed skin needling (needle dermabrasion), seems to be appropriate for the treatment of

G. Fabbrocini; N. Fardella; A. Monfrecola; I. Proietti; D. Innocenzi

2009-01-01

120

Chlorambucil-Induced Acute Interstitial Pneumonitis  

PubMed Central

Chlorambucil is an alkylating agent commonly used in treatment of chronic lymphocytic leukemia (CLL). We report a case of interstitial pneumonitis developing in an 83-year-old man 1.5 months after completing a six-month course of chlorambucil for CLL. The interstitial pneumonitis responded to therapy with prednisone. We performed a systematic review of literature and identified 13 other case reports of chlorambucil-induced pulmonary toxicity, particularly interstitial pneumonitis. No unifying risk factor could be discerned and the mechanism of injury remains unknown. In contrast, major randomized trials of chlorambucil therapy in CLL have not reported interstitial pneumonitis as an adverse effect, which may be due to the rarity of the phenomenon or due to underreporting of events occurring after completion of treatment. Clinicians should consider drug-induced interstitial pneumonitis in the differential diagnosis of a suggestive syndrome developing even after discontinuation of chlorambucil. PMID:24707414

Olszewski, Adam J.

2014-01-01

121

The effect of interstitial gaseous pressure on the thermal conductivity of a simulated Apollo 12 lunar soil sample  

NASA Technical Reports Server (NTRS)

The thermal conductivity of a simulated Apollo 12 soil sample is measured as a function of interstitial gas density, and implications for the thermal properties of lunar and Martian regolith are discussed. Measurements were performed for samples consisting of a mixture of Knippa and Berkely basalt powders with a grain size distribution identical to that of Apollo 12 lunar soil samples by the needle probe technique at interstitial pressures of He, N2, Ar and CO2 from 133,000 to 0.0133 Pa. It is shown that sample thermal conductivity decreases with decreasing interstitial gas pressure down to 1.0 Pa, due to the decreasing effective thermal conductivity of interstitial gas with decreasing gas pressure. Constant thermal conductivity values of 8.8 mW/m per K and 10.9 mW/m per K are obtained for sample densities of 1.70 and 1.85 g/cu cm, respectively, in agreement with in situ lunar regolith measurements. The results, which are greater than those obtained in previous soil studies, are explained by the dense packing of soil particles and enhanced intergranular thermal contact in the present experimental configuration, rather than the influence of interstitial gas pressure. The differences in conductivity between loose soils and packed regolith may also be used to account for the two peaks observed in Martian surface thermal inertia data.

Horai, K.-I.

1981-01-01

122

Ossicular Injury Caused by A Knitting Needle  

PubMed Central

Ossicular chain injury is a complication of trauma caused to temporal bone, but rarely, it can also occur due to direct trauma caused to ossicular chain by a penetrating injury. Patients usually suffering from conductive hearing loss and vertigo, although a facial nerve injury is also a possibility. We are describing here a case of young male who presented with a penetrating trauma to the left ear, caused by a metallic knitting needle, that resulted in ossicular chain disruption. The patient suffered from severe vertigo and conductive hearing loss. He was advised complete bed rest and vertin for controlling vertigo, after which he recovered. Computed tomography is the investigation of choice for detecting and characterizing such injuries, for proper management of patients. Penetrating middle ear trauma differs from blunt trauma, as the mechanism of injury is distinct. The injury is usually isolated and an urgent repair may be needed. Hearing results after an immediate or a delayed ossiculoplasty are apparently satisfying, although late cases are assumed to be associated with adhesions or fibrosis. PMID:24551716

Singh, Amritpal; Kaur, Maninder

2013-01-01

123

Ossicular injury caused by a knitting needle.  

PubMed

Ossicular chain injury is a complication of trauma caused to temporal bone, but rarely, it can also occur due to direct trauma caused to ossicular chain by a penetrating injury. Patients usually suffering from conductive hearing loss and vertigo, although a facial nerve injury is also a possibility. We are describing here a case of young male who presented with a penetrating trauma to the left ear, caused by a metallic knitting needle, that resulted in ossicular chain disruption. The patient suffered from severe vertigo and conductive hearing loss. He was advised complete bed rest and vertin for controlling vertigo, after which he recovered. Computed tomography is the investigation of choice for detecting and characterizing such injuries, for proper management of patients. Penetrating middle ear trauma differs from blunt trauma, as the mechanism of injury is distinct. The injury is usually isolated and an urgent repair may be needed. Hearing results after an immediate or a delayed ossiculoplasty are apparently satisfying, although late cases are assumed to be associated with adhesions or fibrosis. PMID:24551716

Singh, Amritpal; Kaur, Maninder

2013-12-01

124

Energetics of Oxygen Interstitials in Cr and V  

NASA Technical Reports Server (NTRS)

Dissolved oxygen in group IIIA-VA (Nb, Ti, Zr, Y) based alloys is a fundamental problem, affecting both mechanical properties and oxidation resistance, yet details of the phenomenon are poorly understood. In these alloys, oxygen is more stable dissolved in the metal than as an oxide-compound. In contrast, alloys based on Ni, Fe, Al and Cr exhibit almost no oxygen solubility. To improve the performance of Nb and Ti based alloys it is necessary to understand the differences in oxygen solubility between these two groups of metals. As a first step we considered the energetics of interstitial oxygen in alpha-V and alpha-Cr. Both of these metals have a BCC structure, yet the oxygen solubility in V is much higher than that in Cr. We obtain total energies, densities of states and population analyses using the CASTEP plane-wave pseudopotential density functional computer code. The differences in the energetics and electronic structures of the two materials, particularly the partial densities of states associated with the interstitial oxygen, are discussed.

Good, Brian S.; Copland, Evan

2005-01-01

125

Broken anesthetic needle in the pterygomandibular space. Four case reports.  

PubMed

Needle breakage in the oral cavity during local anesthesia is a rare but possible complication. In the majority of cases this happens in the pterygomandibular space during an inferior alveolar nerve block and the causes are multifactorial. The treatment recommended is localization and removal of the extraneous body, as soon as possible, in a surgical setting so as to prevent possible migration of the metal fragment with consequent possible lesions to the surrounding anatomical structures. We present four case studies that have occurred since 2011. PMID:24270204

Catelani, C; Valente, A; Rossi, A; Bertolai, R

2013-01-01

126

Desquamative interstitial pneumonitis and systemic lupus erythematosus  

PubMed Central

Desquamative interstitial pneumonia (DIP) is a rare form of interstitial lung disease (ILD) commonly found among healthy smokers. ILD is a rare manifestation of systemic lupus erythematosus (SLE), and typically associated with a histopathological pattern of nonspecific interstitial pneumonia (NSIP). The present article describes an unusual case of DIP in a non-smoking patient with SLE presenting as NSIP. DIP can occur in the context of SLE in patients with a negative smoking history, and clinicians should consider lung biopsy to correctly classify ILD with unusual presentation on computed tomography scan. PMID:22332137

Esmaeilbeigi, Faranak; Juvet, Stephen; Hwang, David; Mittoo, Shikha

2012-01-01

127

Interstitial Ectopic Pregnancy: Conservative Surgical Management  

PubMed Central

Introduction: Interstitial pregnancy is a rare and life-threatening condition. Diagnosis and appropriate management are critical in preventing morbidity and death. Case Description: Four cases of interstitial pregnancy are presented. Diagnostic laparoscopy followed by laparotomy and cornuostomy with removal of products of conception was performed in 1 case. Laparoscopic cornuostomy and removal of products of conception were performed in the subsequent 3 cases with some modifications of the technique. Subsequent successful reproductive outcomes are also presented. Discussion: Progressively conservative surgical measures are being used to treat interstitial pregnancy successfully, with no negative impact on subsequent pregnancies. PMID:24960482

Warda, Hussein; Mamik, Mamta M.; Ashraf, Mohammad

2014-01-01

128

Kinetics of self-interstitial cluster aggregation near dislocations and their influence on hardening  

E-print Network

Department of Mechanical Engineering, Tokyo University of Science, Chiba, Japan a r t i c l e i n f o Article of SIA clusters. The critical stress to unlock dislocations from self-interstitial atom (SIA) cluster) clusters that readily form in a variety of irradiated bcc, fcc and hcp metals are usually treated as nano

Ghoniem, Nasr M.

129

Selection of suitable sewing needle using machine learning techniques  

Microsoft Academic Search

Selection of suitable sewing needle is one of the most important parameters for ensuring an effective and fault-free sewing process. This task requires good knowledge of basic characteristics of a sewing needle, i.e. needle type, point shape and needle fineness. Also good knowledge of sewing materials is required. The contribution presents an analysis of important parameters that influence the sewing

Zoran Stjepanovic; Helena Strah

1998-01-01

130

Interstitial computing : utilizing spare cycles on supercomputers.  

SciTech Connect

This paper presents an analysis of utilizing unused cycles on supercomputers through the use of many small jobs. What we call 'interstitial computing,' is important to supercomputer centers for both productivity and political reasons. Interstitial computing makes use of the fact that small jobs are more or less fungible consumers of compute cycles that are more efficient for bin packing than the typical jobs on a supercomputer. An important feature of interstitial computing is that it not have a significant impact on the makespan of native jobs on the machine. Also, a facility can obtain higher utilizations that may only be otherwise possible with more complicated schemes or with very long wait times. The key contribution of this paper is that it provides theoretical and empirical guidelines for users and administrators for how currently unused supercomputer cycles may be exploited. We find that that interstitial computing is a more effective means for increasing machine utilization than increasing native job run times or size.

Clearwater, Scott Harvey (Woodside, CA); Kleban, Stephen David

2003-06-01

131

Etiology, Pathogenesis, and Diagnosis of Interstitial Cystitis  

PubMed Central

Interstitial cystitis (IC) is a bladder syndrome of unknown etiology. The cause of IC is most likely multifactorial and includes genetic and environmental factors. Various pathophysiological changes in the bladder, pelvis, and peripheral and central nervous systems have been identified, and this has led to the emergence of biologically specific treatment modalities. Interstitial cystitis is being diagnosed with increasing frequency; however, current diagnostic criteria are non-uniform, and there is significant overlap between chronic pelvic pain syndromes in men and women, interstitial cystitis, recurrent “cystitis,” and the overactive bladder syndrome. The diagnosis of interstitial cystitis can be made clinically and by cystoscopy and hydrodistension. The sensitivity and specificity of urinary markers and the potassium sensitivity test have not been prospectively studied. PMID:16986036

Sant, Grannum R

2002-01-01

132

Imaging of Childhood Interstitial Lung Disease  

PubMed Central

The aphorism that children are not little adults certainly applies for the imaging of interstitial lung disease. Acquiring motion-free images of fine pulmonary structures at desired lung volumes is much more difficult in children than in adults. Several forms of interstitial lung disease are unique to children, and some forms of interstitial lung disease encountered in adults rarely, if ever, occur in children. Meticulous attention to imaging technique and specialized knowledge are required to properly perform and interpret chest imaging studies obtained for the evaluation of childhood interstitial lung disease (chILD). This review will address technique recommendations for imaging chILD, the salient imaging findings in various forms of chILD, and the efficacy of imaging in the diagnosis and management of chILD. PMID:22332031

2010-01-01

133

Interstitial fibrosis and growth factors.  

PubMed Central

Interstitial pulmonary fibrosis (IPF) is scarring of the lung caused by a variety of inhaled agents including mineral particles, organic dusts, and oxidant gases. The disease afflicts millions of individuals worldwide, and there are no effective therapeutic approaches. A major reason for this lack of useful treatments is that few of the molecular mechanisms of disease have been defined sufficiently to design appropriate targets for therapy. Our laboratory has focused on the molecular mechanisms through which three selected peptide growth factors could play a role in the development of IPF. Hundreds of growth factors and cytokines could be involved in the complex disease process. We are studying platelet-derived growth factor because it is the most potent mesenchymal cell mitogen yet described, transforming growth factor beta because it is a powerful inducer of extracellular matrix (scar tissue) components by mesenchymal cells, and tumor necrosis factor alpha because it is a pleiotropic cytokine that we and others have shown is essential for the development of IPF in animal models. This review describes some of the evidence from studies in humans, in animal models, and in vitro, that supports the growth factor hypothesis. The use of modern molecular and transgenic technologies could elucidate those targets that will allow effective therapeutic approaches. Images Figure 1 Figure 2 PMID:10931794

Lasky, J A; Brody, A R

2000-01-01

134

Interstitial lung diseases in children  

PubMed Central

Interstitial lung disease (ILD) in infants and children comprises a large spectrum of rare respiratory disorders that are mostly chronic and associated with high morbidity and mortality. These disorders are characterized by inflammatory and fibrotic changes that affect alveolar walls. Typical features of ILD include dyspnea, diffuse infiltrates on chest radiographs, and abnormal pulmonary function tests with restrictive ventilatory defect and/or impaired gas exchange. Many pathological situations can impair gas exchange and, therefore, may contribute to progressive lung damage and ILD. Consequently, diagnosis approach needs to be structured with a clinical evaluation requiring a careful history paying attention to exposures and systemic diseases. Several classifications for ILD have been proposed but none is entirely satisfactory especially in children. The present article reviews current concepts of pathophysiological mechanisms, etiology and diagnostic approaches, as well as therapeutic strategies. The following diagnostic grouping is used to discuss the various causes of pediatric ILD: 1) exposure-related ILD; 2) systemic disease-associated ILD; 3) alveolar structure disorder-associated ILD; and 4) ILD specific to infancy. Therapeutic options include mainly anti-inflammatory, immunosuppressive, and/or anti-fibrotic drugs. The outcome is highly variable with a mortality rate around 15%. An overall favorable response to corticosteroid therapy is observed in around 50% of cases, often associated with sequelae such as limited exercise tolerance or the need for long-term oxygen therapy. PMID:20727133

2010-01-01

135

Sliding Mode Control of Steerable Needles  

PubMed Central

Steerable needles can potentially increase the accuracy of needle-based diagnosis and therapy delivery, provided they can be adequately controlled based on medical image information. We propose a novel sliding mode control law that can be used to deliver the tip of a flexible asymmetric-tipped needle to a desired point, or to track a desired trajectory within tissue. The proposed control strategy requires no a priori knowledge of model parameters, has bounded input speeds, and requires little computational resources. We show that if the standard nonholonomic model for tip-steered needles holds, then the control law will converge to desired targets in a reachable workspace, within a tolerance that can be defined by the control parameters. Experimental results validate the control law for target points and trajectory following in phantom tissue and ex vivo liver. Experiments with targets that move during insertion illustrate robustness to disturbances caused by tissue deformation. PMID:25400527

Rucker, D. Caleb; Das, Jadav; Gilbert, Hunter B.; Swaney, Philip J.; Miga, Michael I.; Sarkar, Nilanjan; Webster, Robert J.

2014-01-01

136

COMPARISONS OF NEEDLE INSERTION IN BRACHYTHERAPY  

E-print Network

aims at comparing the results of different prostate brachytherapy protocols concerning needle insertion order and its influence on tissue deformations. Prostate brachytherapy of other parameters was also demonstrated through the different simulations. PROSTATE BRACHYTHERAPY

Promayon, Emmanuel

137

Finite element model of needle electrode sensitivity  

NASA Astrophysics Data System (ADS)

We used the Finite Element (FE) Method to estimate the sensitivity of a needle electrode for bioimpedance measurement. This current conducting needle with insulated shaft was inserted in a saline solution and current was measured at the neutral electrode. FE model resistance and reactance were calculated and successfully compared with measurements on a laboratory model. The sensitivity field was described graphically based on these FE simulations.

Høyum, P.; Kalvøy, H.; Martinsen, Ø. G.; Grimnes, S.

2010-04-01

138

Interstitial cystitis. Etiology, diagnosis, and treatment.  

PubMed Central

OBJECTIVE: To review current knowledge about the epidemiology, etiology, diagnosis, and treatment of interstitial cystitis, with special emphasis on management of this condition by family physicians. QUALITY OF EVIDENCE: Articles were identified through MEDLINE and review of abstracts presented at Urology and Interstitial Cystitis meetings during the last decade. Recent reviews were further searched for additional studies and trials. Data were summarized from large epidemiologic studies. Etiologic theories were extracted from current concepts and reviews of scientific studies. Diagnostic criteria described in this review are based on clinical interpretation of National Institutes of Health (NIH) research guidelines, interpretation of data from the NIH Interstitial Cystitis Cohort Study, and recent evidence on use of the potassium sensitivity test. Treatment suggestions are based on six randomized placebo-controlled clinical treatment trials and best available clinical data. MAIN MESSAGE: Interstitial cystitis affects about 0.01% to 0.5% of women. Its etiology is unknown, but might involve microbiologic, immunologic, mucosal, neurogenic, and other yet undefined agents. The diagnosis of interstitial cystitis is a diagnosis of exclusion. It is impossible to provide a purely evidence-based treatment strategy, but review of available evidence suggests that conservative supportive therapy (including diet modification); oral treatment with pentosan polysulfate, amitriptyline, or hydroxyzine; and intravesical treatments with heparinlike medications, dimethyl sulfoxide, or BCG vaccine could benefit some patients. CONCLUSION: Family physicians should have an understanding of interstitial cystitis and be able to make a diagnosis and formulate an evidence-based treatment strategy for their patients. PMID:11153410

Nickel, J. C.

2000-01-01

139

Neural upregulation in interstitial cystitis.  

PubMed

Interstitial cystitis (IC) is a syndrome of bladder hypersensitivity with symptoms of urgency, frequency, and chronic pelvic pain. Although no consensus has been reached on the underlying cause of IC, several pathophysiologic mechanisms, including epithelial dysfunction, mast cell activation, and neurogenic inflammation, have been proposed. Despite multiple different causes of urinary cystitis, the bladder's response to cystitis is limited and typical. Animal experiments have shown upregulation of proteinase-activated receptors, tryptase, beta-nerve growth factor, inducible nitric oxide synthase, nuclear transcription factor-kappaB, c-Fos, phosphodiesterase 1C, cyclic adenosine monophosphate (cAMP)-dependent protein kinase, and proenkephalin B. After the noxious stimulus has abated, downregulation of genes appears to follow. Distention of the bladder results in the release of adenosine triphosphate (ATP) from urothelial cells, which activates purinergic P2X3 receptors. Activation by ATP of P2X3-expressing afferents is a fundamental signaling factor in bladder sensation and appears to play a role in bladder reflexes. Fos proteins present in spinal cord neurons have been shown to be upregulated in animals that have undergone cyclophosphamide-induced chemical cystitis. These and other findings suggest that neural upregulation occurs both peripherally and centrally in subjects with chronic cystitis. It is unclear whether neural mechanisms and inflammation are the cause of IC or the result of other initiating events. Neural upregulation is known to play a role in the chronicity of pain, urgency, and frequency and represents an exciting area of research that may lead to additional treatments and a better understanding of IC. PMID:17462476

Nazif, Omar; Teichman, Joel M H; Gebhart, G F

2007-04-01

140

Needle-in-Needle Technique for Percutaneous Retrieval of a Fractured Biopsy Needle during CT-Guided Biopsy of the Thoracic Spine.  

PubMed

Common complications related to CT-guided percutaneous thoracic bone biopsy procedures include pneumothorax and muscular hematoma. Serious, but rare complications include paralysis, nerve injury, CSF leak, and aortic injury. Device failure has not been well documented in the literature. We discuss our experience with biopsy needle breakage during retrieval of a core specimen and the technique used to help retrieve an embedded needle using a CT fluoroscopic-guided, needle-in-needle approach. A 43 year-old man with Stage IIIa NSCLC was found to have a T11 vertebral body lesion as seen on PET, CT, and MR imaging. The patient underwent a CT-guided biopsy in the prone position. The T11 vertebral body was localized and cannulated using the percutaneous Bonopty(®) (Apriomed, Upsala, Sweden) needle device. After fine needle aspiration samples were obtained, a core needle biopsy was attempted with a 16-gauge device. The needle fractured 4 cm deep to the skin during removal of a sclerotic lesion, leaving a retained portion within the pedicle and vertebral body. Using CT-guided fluoroscopy, a large diameter Murphy M2 needle was advanced over the distal portion of the fractured Bonopty needle. The Murphy M2 needle was advanced distal to the tip of the Bonopty needle and removed, capturing the broken Bonopty penetration needle along with a core specimen. Larger-bore biopsy needle systems and/or a coaxial system should be used to perform core biopsies in sclerotic lesions to prevent device fracture. If there is device fracture, a larger-bore needle may be used to help capture the fractured needle and prevent open surgery. PMID:25363270

Shaikh, Hamza; Thawani, Jayesh; Pukenas, Bryan

2014-10-31

141

Incidence and severity of Arcanobacterium pyogenes injection site abscesses with needle or needle-free injection.  

PubMed

Nursery-age pigs (n=198) were used to evaluate the difference in abscess formation at needle-free jet and conventional needle-and-syringe injection sites. Needle-free jet injection was used to administer injections in the neck and ham on one side of the animal whereas needle-and-syringe was used for neck and ham injections on the opposite side. Immediately prior to injection, the injection site surfaces were contaminated with an inoculum of Arcanobacterium pyogenes. Each pig was humanely euthanized 27 or 28 days after injections. Histopathological results showed that needle-free jet injection was associated with more abscesses than needle-and-syringe injection at both neck (P=0.0625) and ham (P=0.0313) injection sites. Out of 792 injection sites, only 13 abscesses were observed, with 12 of those present at needle-free jet injection sites. Needle-free jet injection may increase the occurrence of injection site abscesses that necessitate carcass trimming at pork processing plants. PMID:22854129

Gerlach, Bryce M; Houser, Terry A; Hollis, Larry C; Tokach, Michael D; Nietfeld, Jerome C; Higgins, James J; Anderson, Gary A; Goehring, Brandon L

2012-12-01

142

An overview of interstitial brachytherapy and hyperthermia  

SciTech Connect

Interstitial thermoradiotherapy, an experimental cancer treatment that combines interstitial radiation implants (brachytherapy) and interstitial hyperthermia, is in the early stages of investigation. In accordance with the procedure used in a current national trial protocol, a 60-minute hyperthermia treatment is administered after catheters are placed into the tumor area while the patient is under general anesthesia. This is immediately followed by loading of radioactive Iridium-192 seeds into the catheters for a defined period of time. Once the prescribed radiation dose is delivered, the radioactive sources are removed and a second, 60-minute hyperthermia treatment is administered. Clinical trials with hyperthermia in combination with radiation have increased in recent years. Nurses caring for these patients need to become more knowledgeable about this investigational therapy. This paper provides an overview of the biologic rationale for this therapy, as well as a description of the delivery method and clinical application. Specific related nursing interventions are defined in a nursing protocol.23 references.

Brandt, B.B.; Harney, J.

1989-11-01

143

Calculations of Silicon Self-Interstitial Defects  

NASA Astrophysics Data System (ADS)

We report a theoretical study of self-interstitial defects in silicon using local density approximation (LDA), PW91 generalized gradient approximation (GGA), and fixed-node diffusion quantum Monte Carlo (DMC) methods. The formation energies of the stablest interstitial defects are about 3.3 eV within the LDA, 3.8 eV within the PW91-GGA, and 4.9 eV within DMC. The DMC results indicate a value for the formation + migration energy of the self-interstitial contribution to self-diffusion of about 5 eV, which is consistent with the experimental data. This confirms the importance of a proper treatment of electron correlation when studying such systems.

Leung, W.-K.; Needs, R. J.; Rajagopal, G.; Itoh, S.; Ihara, S.

1999-09-01

144

Wear evaluation of high interstitial stainless steel  

SciTech Connect

A new series of high nitrogen-carbon manganese stainless steel alloys are studied for their wear resistance. High nitrogen and carbon concentrations were obtained by melting elemental iron-chromium-manganese (several with minor alloy additions of nickel, silicon, and molybdenum) in a nitrogen atmosphere and adding elemental graphite. The improvement in material properties (hardness and strength) with increasing nitrogen and carbon interstitial concentration was consistent with previously reported improvements in similar material properties alloyed with nitrogen only. Wear tests included: scratch, pin-on-disk, sand-rubber-wheel, impeller, and jet erosion. Additions of interstitial nitrogen and carbon as well as interstitial nitrogen and carbide precipitates were found to greatly improve material properties. In general, with increasing nitrogen and carbon concentrations, strength, hardness, and wear resistance increased.

Rawers, J.C.; Tylczak, J.H.

2008-07-01

145

Conformal needle-based ultrasound ablation using EM-tracked conebeam CT image guidance  

NASA Astrophysics Data System (ADS)

Numerous studies have demonstrated the efficacy of interstitial ablative approaches for the treatment of renal and hepatic tumors. Despite these promising results, current systems remain highly dependent on operator skill, and cannot treat many tumors because there is little control of the size and shape of the zone of necrosis, and no control over ablator trajectory within tissue once insertion has taken place. Additionally, tissue deformation and target motion make it extremely difficult to accurately place the ablator device into the target. Irregularly shaped target volumes typically require multiple insertions and several sequential thermal ablation procedures. This study demonstrated feasibility of spatially tracked image-guided conformal ultrasound (US) ablation for percutaneous directional ablation of diseased tissue. Tissue was prepared by suturing the liver within a pig belly and 1mm BBs placed to serve as needle targets. The image guided system used integrated electromagnetic tracking and cone-beam CT (CBCT) with conformable needlebased high-intensity US ablation in the interventional suite. Tomographic images from cone beam CT were transferred electronically to the image-guided tracking system (IGSTK). Paired-point registration was used to register the target specimen to CT images and enable navigation. Path planning is done by selecting the target BB on the GUI of the realtime tracking system and determining skin entry location until an optimal path is selected. Power was applied to create the desired ablation extent within 7-10 minutes at a thermal dose (>300eqm43). The system was successfully used to place the US ablator in planned target locations within ex-vivo kidney and liver through percutaneous access. Targeting accuracy was 3-4 mm. Sectioned specimens demonstrated uniform ablation within the planned target zone. Subsequent experiments were conducted for multiple ablator positions based upon treatment planning simulations. Ablation zones in liver were 73cc, 84cc, and 140cc for 3, 4, and 5 placements, respectively. These experiments demonstrate the feasibility of combining real-time spatially tracked image guidance with directional interstitial ultrasound ablation. Interstitial ultrasound ablation delivered on multiple needles permit the size and shape of the ablation zone to be "sculpted" by modifying the angle and intensity of the active US elements in the array. This paper summarizes the design and development of the first system incorporating thermal treatment planning and integration of a novel interstitial acoustic ablation device with integrated 3D electromagnetic tracking and guidance strategy.

Burdette, E. Clif; Banovac, Filip; Diederich, Chris J.; Cheng, Patrick; Wilson, Emmanuel; Cleary, Kevin R.

2011-03-01

146

[Interstitial lung disease in connective tissue disorders].  

PubMed

After immunosuppressive-induced infections, interstitial lung disease (ILD) is one of the most serious pulmonary complications associated with connective tissue diseases (CTD). Although it is common for ILD to be diagnosed concurrent with or after CTD, some patients will present with ILD years prior to receiving a diagnosis of CTD. The clinical approach involves an examination of the extrathoracic symptoms (suggestive of CTD) and the evaluation of respiratory disability. Nonspecific interstitial pneumonia is the most common histological finding in patients with CTD. The management of patients with CTD-associated ILD is optimized by multidisciplinary collaboration. ILD-CTD are treated through anti-inflammatory medication, immunosuppressants and biological agents. PMID:25362775

Carmier, Delphine; Diot, Élisabeth; Guilleminault, Laurent; Marchand-Adam, Sylvain

2014-09-01

147

Syringe and Needle Size, Syringe Type, Vacuum Generation, and Needle Control in Aspiration Procedures  

SciTech Connect

Purpose: Syringes are used for diagnostic fluid aspiration and fine-needle aspiration biopsy in interventional procedures. We determined the benefits, disadvantages, and patient safety implications of syringe and needle size on vacuum generation, hand force requirements, biopsy/fluid yield, and needle control during aspiration procedures. Materials and Methods: Different sizes (1, 3, 5, 10, and 20 ml) of the conventional syringe and aspirating mechanical safety syringe, the reciprocating procedure device, were studied. Twenty operators performed aspiration procedures with the following outcomes measured: (1) vacuum (torr), (2) time to vacuum (s), (3) hand force to generate vacuum (torr-cm{sup 2}), (4) operator difficulty during aspiration, (5) biopsy yield (mg), and (6) operator control of the needle tip position (mm). Results: Vacuum increased tissue biopsy yield at all needle diameters (P < 0.002). Twenty-milliliter syringes achieved a vacuum of -517 torr but required far more strength to aspirate, and resulted in significant loss of needle control (P < 0.002). The 10-ml syringe generated only 15% less vacuum (-435 torr) than the 20-ml device and required much less hand strength. The mechanical syringe generated identical vacuum at all syringe sizes with less hand force (P < 0.002) and provided significantly enhanced needle control (P < 0.002). Conclusions: To optimize patient safety and control of the needle, and to maximize fluid and tissue yield during aspiration procedures, a two-handed technique and the smallest syringe size adequate for the procedure should be used. If precise needle control or one-handed operation is required, a mechanical safety syringe should be considered.

Haseler, Luke J., E-mail: l.haseler@griffith.edu.au [Griffith University, Heart Foundation Research Centre, Griffith Health Institute (Australia); Sibbitt, Randy R., E-mail: THESIBB2@aol.com [Montana Interventional and Dgnstc Radiation (United States); Sibbitt, Wilmer L., E-mail: wsibbitt@salud.unm.edu [University of New Mexico Health Sciences Center, Department of Internal Medicine (United States); Michael, Adrian A., E-mail: adrian_a_michael@yahoo.com [Texas Tech University Health Sciences Center, Department of Internal Medicine (United States); Gasparovic, Charles M., E-mail: chuck@unm.edu [University of New Mexico Health Sciences Center, MIND Institute at the University of New Mexico (United States); Bankhurst, Arthur D., E-mail: abankhurst@salud.unm.edu [University of New Mexico Health Sciences Center, Department of Internal Medicine (United States)

2011-06-15

148

The Snoek relaxation in bcc metals—From steel wire to meteorites  

Microsoft Academic Search

Heavy interstitial atoms, such as O, N, or C, when dissolved in bcc metals (Fe, Nb, Ta, V), induce elastic dipoles with tetragonal symmetry. The stress induced reorientation produces anelastic relaxation and is the elementary step of interstitial diffusion. Mechanical loss spectra indicate the presence of interstitial atoms by Snoek peaks at distinct, characteristic temperatures. The magnitude of the peaks

M. Weller

2006-01-01

149

A new miniature x-ray source for interstitial radiosurgery: device description.  

PubMed

A device that generates low-energy x rays at the tip of a needle-like probe was developed for stereotactic interstitial radiosurgery. Electrons from a small thermionic gun are accelerated to a final energy of up to 40 keV and directed along a 3 mm outside diameter drift tube to a thin Au target, where the beam size is approximately 0.3 mm. All high-voltage electronics are in the probe housing, connected by low-voltage cable to a battery-operated control box. X-ray output, which is nearly isotropic, consists of a bremsstrahlung spectrum and several lines between 7 and 14 keV, with characteristic radiation contributing 15% of the total energy output. To date, 14 patients with metastatic brain tumors have been treated with this device. PMID:8700032

Dinsmore, M; Harte, K J; Sliski, A P; Smith, D O; Nomikos, P M; Dalterio, M J; Boom, A J; Leonard, W F; Oettinger, P E; Yanch, J C

1996-01-01

150

Analysis of the NovoTwist Pen Needle in Comparison with Conventional Screw-Thread Needles  

PubMed Central

Administration of insulin via a pen device may be advantageous over a vial and syringe system. Hofman and colleagues introduce a new insulin pen needle, the NovoTwist, to simplify injections to a small group of children and adolescents. Their overall preferences and evaluation of the handling of the needle are reported in the study. This new needle has the potential to ease administration of insulin via a pen device that may increase both the use of a pen device and adherence to insulin therapy. PMID:22226270

Aye, Tandy

2011-01-01

151

21 CFR 884.6100 - Assisted reproduction needles.  

Code of Federal Regulations, 2011 CFR

...2011-04-01 2011-04-01 false Assisted reproduction needles. 884.6100 Section 884...OBSTETRICAL AND GYNECOLOGICAL DEVICES Assisted Reproduction Devices § 884.6100 Assisted reproduction needles. (a) Identification....

2011-04-01

152

21 CFR 884.6100 - Assisted reproduction needles.  

Code of Federal Regulations, 2012 CFR

...2012-04-01 2012-04-01 false Assisted reproduction needles. 884.6100 Section 884...OBSTETRICAL AND GYNECOLOGICAL DEVICES Assisted Reproduction Devices § 884.6100 Assisted reproduction needles. (a) Identification....

2012-04-01

153

21 CFR 884.6100 - Assisted reproduction needles.  

Code of Federal Regulations, 2013 CFR

...2013-04-01 2013-04-01 false Assisted reproduction needles. 884.6100 Section 884...OBSTETRICAL AND GYNECOLOGICAL DEVICES Assisted Reproduction Devices § 884.6100 Assisted reproduction needles. (a) Identification....

2013-04-01

154

21 CFR 884.6100 - Assisted reproduction needles.  

...2014-04-01 2014-04-01 false Assisted reproduction needles. 884.6100 Section 884...OBSTETRICAL AND GYNECOLOGICAL DEVICES Assisted Reproduction Devices § 884.6100 Assisted reproduction needles. (a) Identification....

2014-04-01

155

21 CFR 868.5090 - Emergency airway needle.  

Code of Federal Regulations, 2010 CFR

...needle. (a) Identification. An emergency airway needle is a device intended to puncture a patient's cricothyroid membrane to provide an emergency airway during upper airway obstruction. (b) Classification. Class II...

2010-04-01

156

21 CFR 868.5090 - Emergency airway needle.  

...needle. (a) Identification. An emergency airway needle is a device intended to puncture a patient's cricothyroid membrane to provide an emergency airway during upper airway obstruction. (b) Classification. Class II...

2014-04-01

157

21 CFR 868.5090 - Emergency airway needle.  

Code of Federal Regulations, 2011 CFR

...needle. (a) Identification. An emergency airway needle is a device intended to puncture a patient's cricothyroid membrane to provide an emergency airway during upper airway obstruction. (b) Classification. Class II...

2011-04-01

158

21 CFR 868.5090 - Emergency airway needle.  

Code of Federal Regulations, 2012 CFR

...needle. (a) Identification. An emergency airway needle is a device intended to puncture a patient's cricothyroid membrane to provide an emergency airway during upper airway obstruction. (b) Classification. Class II...

2012-04-01

159

21 CFR 868.5090 - Emergency airway needle.  

Code of Federal Regulations, 2013 CFR

...needle. (a) Identification. An emergency airway needle is a device intended to puncture a patient's cricothyroid membrane to provide an emergency airway during upper airway obstruction. (b) Classification. Class II...

2013-04-01

160

Topological criterion for metallic glass formation  

Microsoft Academic Search

A topological model is proposed for metallic glass formation through destabilization of the host crystalline lattice by substitutional and\\/or interstitial solute elements. A solute element may partition between substitutional and interstitial sites and the model calculates relative site frequency as a function of the strain energy associated with each site. The strain energy, in turn, depends upon solute and solvent

D. B Miracle; O. N Senkov

2003-01-01

161

Computer-assisted interstitial laser coagulation for BPH  

NASA Astrophysics Data System (ADS)

Interstitial laser thermotherapy is a minimally invasive surgical procedure that utilizes laser to coagulate and treat benign prostatic hyperplasia. This study explores the use of a computer-assisted interstitial laser coagulation system to aid surgeons in performing this procedure.

Ho, Gideon; Barrett, Adrian R. W.; Ng, Wan S.; Lim, Liam G.; Cheng, Wai S.

2001-06-01

162

Needle Path Planning for Autonomous Robotic Surgical Suturing  

PubMed Central

This paper develops a path plan for suture needles used with solid tissue volumes in endoscopic surgery. The path trajectory is based on the best practices that are used by surgeons. The path attempts to minimize the interaction forces between the tissue and the needle. Using surgical guides as a basis, two different techniques for driving a suture needle are developed. The two techniques are compared in hardware experiments by robotically driving the suture needle using both of the motion plans. PMID:24683500

Jackson, Russell C.; Çavu?o?lu, M. Cenk

2013-01-01

163

A tale of two compartments: interstitial versus blood glucose monitoring.  

PubMed

Self-monitoring of blood glucose was described as one of the most important advancements in diabetes management since the invention of insulin in 1920. Recent advances in glucose sensor technology for measuring interstitial glucose concentrations have challenged the dominance of glucose meters in diabetes management, while raising questions about the relationships between interstitial and blood glucose levels. This article will review the differences between interstitial and blood glucose and some of the challenges in measuring interstitial glucose levels accurately. PMID:19469670

Cengiz, Eda; Tamborlane, William V

2009-06-01

164

A Tale of Two Compartments: Interstitial Versus Blood Glucose Monitoring  

PubMed Central

Abstract Self-monitoring of blood glucose was described as one of the most important advancements in diabetes management since the invention of insulin in 1920. Recent advances in glucose sensor technology for measuring interstitial glucose concentrations have challenged the dominance of glucose meters in diabetes management, while raising questions about the relationships between interstitial and blood glucose levels. This article will review the differences between interstitial and blood glucose and some of the challenges in measuring interstitial glucose levels accurately. PMID:19469670

Tamborlane, William V.

2009-01-01

165

Interstitial photodynamic laser therapy in interventional oncology  

Microsoft Academic Search

Photodynamic therapy (PDT) is a well-investigated locoregional cancer treatment in which a systemically administered photosensitizer is activated locally by illuminating the diseased tissue with light of a suitable wavelength. PDT offers various treatment strategies in oncology, especially palliative ones. This article focuses on the development and evaluation of interstitial PDT for the treatment of solid tumors, particularly liver tumors. The

Thomas J. Vogl; Katrin Eichler; Martin G. Mack; Stephan Zangos; Christopher Herzog; Axel Thalhammer; Kerstin Engelmann

2004-01-01

166

A PDMS interstitial fluid transdermal extraction tool  

Microsoft Academic Search

We present a microfluidic based interstitial fluid (ISF) transdermal extraction tool fabricated from polydimethylsiloxane (PDMS), designed towards the application of continuous glucose monitoring. This device consists of a Venturi Tube for vacuum generation, chambers for the introduction of ISF and normal saline solution, pneumatic valves for fluid control, and interconnected microchannels. Vacuum pressure is used for fluid manipulation and a

Haixia Yu; Robert C. Roberts; Dachao Li; Kexin Xu; Norman C. Tien

2010-01-01

167

Ultrasound in the evaluation of interstitial pneumonia  

PubMed Central

Background The diagnostic value of thoracic ultrasonography (US) has recently increased. Skilled sonographers with experience in pulmonary medicine have demonstrated the existence of US signs of chest pathology. Purpose To detect US findings associated with infectious interstitial pneumonia that can be used to supplement other diagnostic tools. Materials and methods Over a period of 5 years (2001–2006), 55 patients were referred to our ultrasonography units for evaluation of probable viral or viral-like infections of the respiratory tract. Each patient was subjected to a work-up that included clinical examination, blood tests, pulmonary function tests, bronchoscopy, chest radiographs, high-resolution computed tomography (HRCT), and thoracic US, which was performed under blinded conditions. Results Based on the findings that emerged from the work-up described above, all 55 patients were diagnosed with interstitial pneumonia. Evaluation of the US scans for the signs of interstitial lung disease described by Lichtenstein revealed “comet-tail” artifacts in the anterolateral lung fields in 31 (56.36%) patients and mixed patterns consisting in increased density associated with ring-down artifacts in 24 (46.64%). Pleural involvement was also observed in 34 cases (61.82%). Conclusions Thoracic US appears to be a useful adjunct to clinical, laboratory and radiological studies in patients suspected of having infectious interstitial pneumonia. PMID:23396220

Lo Giudice, V.; Bruni, A.; Corcioni, E.; Corcioni, B.

2008-01-01

168

The relationship between fibromyalgia and interstitial cystitis  

Microsoft Academic Search

Interstitial cystitis (IC) is a relatively uncommon and enigmatic disorder characterized by pain in the bladder and pelvic region, typically accompanied by urinary urgency and frequency. Fibromyalgia is a more common disorder, with the prominent symptoms being diffuse musculoskeletal pain and fatigue, and it has been well established that there is substantial clinical overlap between fibromyalgia and chronic fatigue syndrome

Daniel J. Clauw; Maria Schmidt; David Radulovic; Andrea Singer; Paul Katz; John Bresette

1997-01-01

169

Interstitial lung diseases in collagen vascular diseases.  

PubMed

In this review, a clinical update is presented of the most important collagen vascular diseases (CVDs) and the different types of interstitial lung disease (ILD) encountered in these CVDs. These CVDs represent a heterogenous group of immunologically mediated inflammatory disorders with a large variety of affected organs besides the lungs. The frequency, clinical presentation, prognosis and response to therapy vary depending on the histological pattern (usual interstitial pneumonia, desquamative interstitial pneumonia, organising pneumonia, diffuse alveolar damage, nodular lesions, etc.), as well as on the underlying CVD (scleroderma, rheumatoid arthritis, systemic lupus erythematosus, dermatopolymyositis, Sjogren's syndrome or mixed connective tissue disease). The diagnosis of most of these CVDs is based on a number of criteria; in several of these, however, lung involvement is not part of the diagnostic criteria. In addition, there may be overlaps between several of these CVDs. Optimal treatment varies depending on the type of collagen vascular disease and the presence of interstitial lung disease, although in many cases, a combination of corticosteroids and cytostatic drugs are given. PMID:11816826

Lamblin, C; Bergoin, C; Saelens, T; Wallaert, B

2001-09-01

170

Interstitial cystitis: early diagnosis, pathology, and treatment.  

PubMed

In a retrospective review, 52 patients with interstitial cystitis have been studied. Patients with persistent lower tract irritative symptoms, repeatedly sterile urine, and negative urine cytology must be suspected of having interstitial cystitis, and a diagnosis of urethral syndrome in such patients is highly questionable until cystoscopy under anesthesia has been performed. We believe that the finding of multiple petechia-like hemorrhages (glomerulations) on the second distention of the bladder is the hallmark of interstitial cystitis, and that a reduced bladder capacity and a Hunner's ulcer represent a different (classic) stage of this disease. In all stages, the characteristic histologic finidng is submucosal edema and vasodilation. The presence of eosinophils and mast cells is variable, and even in the classic disease the muscularis often appears to be normal. Immuno fluorescent studies and laboratory tests, including the fluorescent antinuclear antibody test (FANA), have not helped us to diagnose (or investigate) interstitial cystitis. Bladder instillations with a 0.4 per cent solution of oxychlorosene sodium (Clorpactin WCS-90) have provided remarkable relief for many patients with this disease, particulary those with the classic form. PMID:213864

Messing, E M; Stamey, T A

1978-10-01

171

Creeping Motion of Self Interstitial Atom Clusters in Tungsten  

PubMed Central

The formation and motion features of self interstitial atom (SIA) clusters in tungsten are studied by molecular dynamics (MD) simulations. The static calculations show that the SIA clusters are stable with binding energy over 2?eV. The SIA clusters exhibit a fast one dimensional (1D) motion along ?111?. Through analysis of the change of relative distance between SIAs, we find that SIAs jump in small displacements we call creeping motion, which is a new collective diffusion process different from that of iron. The potential energy surface of SIAs implicates that the creeping motion is due to the strong interaction between SIAs. These imply that several diffusion mechanism for SIA clusters can operate in BCC metals and could help us explore deep insight into the performance of materials under irradiation. PMID:24865470

Zhou, Wang Huai; Zhang, Chuan Guo; Li, Yong Gang; Zeng, Zhi

2014-01-01

172

Direct observation of interstitial dislocation loop coarsening in ?-iron.  

PubMed

Interstitial loop coarsening by Ostwald ripening can provide insight into single point defects but is very difficult to observe in ?-iron and many other metals where nanoscale vacancy clusters dissociate and annihilate loops. We show that by implanting helium in the samples at a carefully chosen energy, it is possible to observe Ostwald ripening of loops by transmission electron microscopy during in situ isochronal annealings. This coarsening of loops results in a sharp increase of the mean loop radius at around 850 K. Using cluster dynamics simulations, we demonstrate that loops evolve due to vacancy emission and that such experiments give a robust estimation of the sum of the formation and migration free energies of vacancies. In particular, our results are in good agreement with self-diffusion experiments and confirm that entropic contributions are large for the vacancy in ?-iron. PMID:23863013

Moll, S; Jourdan, T; Lefaix-Jeuland, H

2013-07-01

173

Creeping Motion of Self Interstitial Atom Clusters in Tungsten  

NASA Astrophysics Data System (ADS)

The formation and motion features of self interstitial atom (SIA) clusters in tungsten are studied by molecular dynamics (MD) simulations. The static calculations show that the SIA clusters are stable with binding energy over 2 eV. The SIA clusters exhibit a fast one dimensional (1D) motion along <111>. Through analysis of the change of relative distance between SIAs, we find that SIAs jump in small displacements we call creeping motion, which is a new collective diffusion process different from that of iron. The potential energy surface of SIAs implicates that the creeping motion is due to the strong interaction between SIAs. These imply that several diffusion mechanism for SIA clusters can operate in BCC metals and could help us explore deep insight into the performance of materials under irradiation.

Zhou, Wang Huai; Zhang, Chuan Guo; Li, Yong Gang; Zeng, Zhi

2014-05-01

174

The Double-Needle Felling Machine. Module 17.  

ERIC Educational Resources Information Center

This module on the double-needle felling machine, one in a series dealing with industrial sewing machines, their attachments, and operation, covers two topics: performing special operations on the double-needle felling machine (straight seams) and performing special operations on the double-needle felling machine (curved flat-felled seams). For…

South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

175

Sensorless Motion Planning for Medical Needle Insertion in Deformable Tissues  

Microsoft Academic Search

Minimally invasive medical procedures such as biopsies, anesthesia drug injections, and brachytherapy cancer treatments require inserting a needle to a specific target inside soft tissues. This is difficult because needle insertion displaces and deforms the surrounding soft tissues causing the target to move during the procedure. To facilitate physician training and preoperative planning for these procedures, we develop a needle

Ron Alterovitz; Kenneth Y. Goldberg; Jean Pouliot; I-Chow Hsu

2009-01-01

176

Evaluation of Robotic Needle Steering in ex vivo Tissue.  

PubMed

Insertion velocity, tip asymmetry, and shaft diameter may influence steerable needle insertion paths in soft tissue. In this paper we examine the effects of these variables on needle paths in ex vivo goat liver, and demonstrate practical applications of robotic needle steering for ablation, biopsy, and brachytherapy. All experiments were performed using a new portable needle steering robot that steers asymmetric-tip needles under fluoroscopic imaging. For bevel-tip needles, we found that larger diameter needles resulted in less curvature, i.e. less steerability, confirming previous experiments in artificial tissue. The needles steered with radii of curvature ranging from 3:4 cm (for the most steerable pre-bent needle) to 2:97m (for the least steerable bevel needle). Pre-bend angle significantly affected needle curvature, but bevel angle did not. We hypothesize that biological tissue characteristics such as inhomogeneity and viscoelasticity significantly increase path variability. These results underscore the need for closed-loop image guidance for needle steering in biological tissues with complex internal structure. PMID:21339851

Majewicz, Ann; Wedlick, Thomas R; Reed, Kyle B; Okamura, Allison M

2010-05-01

177

Interactive simulation of surgical needle insertion and steering  

Microsoft Academic Search

We present algorithms for simulating and visualizing the insertion and steering of needles through deformable tissues for surgical training and planning. Needle insertion is an essential component of many clinical procedures such as biopsies, injections, neurosurgery, and brachytherapy cancer treatment. The success of these procedures depends on accurate guidance of the needle tip to a clinical target while avoiding vital

Nuttapong Chentanez; Ron Alterovitz; Daniel Ritchie; Lita Cho; Kris K. Hauser; Ken Goldberg; Jonathan R. Shewchuk; James F. O'Brien

2009-01-01

178

An optical smart needle : point-of-care technologies for integrated needle guidance using optical frequency domain ranging  

E-print Network

Obtaining accurate needle placement is of critical importance in many medical scenarios. In the setting of fine needle aspiration biopsy (FNAB), manual palpation is often the only cue for determining the optimal position ...

Goldberg, Brian, 1979-

2009-01-01

179

Identification of Early Interstitial Lung Disease in Smokers from the  

E-print Network

interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPFIdentification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R

180

Electroencephalogram with Sphenoidal Needles in Sleepwalkers  

Microsoft Academic Search

The etiology of sleepwalking is controversial, the theory that sleepwalking is an epilepsy-like symptom is mostly discounted. Electroencephalogram records, obtained by using sphenoidal needles, are presented as a useful technique and aid to etiological and topical diagnosis. A temporal focus of waves of 4–6 cps was recorded which was not found in the routine EEG procedures. The question is thus

Uriel Halbreich; Marcel Assael

1978-01-01

181

Melnick-Needles syndrome in males.  

PubMed

Melnick-Needles syndrome is an X-linked dominant trait, lethal in males. There are three well-documented lethal examples of the disorder in the offspring of affected females and three examples in males born to normal parents who represent new mutations. PMID:3605193

Krajewska-Walasek, M; Winkielman, J; Gorlin, R J

1987-05-01

182

Percutaneous needle aspiration of neonatal lung abscesses  

Microsoft Academic Search

Three premature infants (mean gestational age 27 weeks) ranging in age from 3 to 11 weeks, were treated for lung abscesses, with a combination of antibiotics and percutaneous needle aspiration under either ultrasound or fluoroscopic guidance. Antibiotics, to which microorganisms cultured from aspirated pus were sensitive, were continued for a further period of two weeks, with no relapse in any

S. K. Lee; R. F. Morris; B. Cramer

1991-01-01

183

Buffon Needle Problem Application to Space Exploration  

E-print Network

In this article the possibility of application of classical Buffon needle problem to the investigation of orientation engine firing problem has been investigated. Such an approach makes it possible to get a reliable EP of this undesired event without using a more complicated analysis.

A. V. Sedelnikov

2010-06-01

184

Percutaneous needle treatment of liver tumors  

E-print Network

· Percutaneous needle treatment of liver tumors · Target multiple tumors through a single incisionmm x 90mm x 260mm · Autoclavable I. Free Space III. Bovine Liver · Precurved concentric nitinol tubes.80 Bovine Liver (mm) 3.32 ± 2.66 II. Ethanol Solution Future Work · Human trials with manual unit · Fully

Webster III, Robert James

185

Vocational Home Economics Education. Needle Trades.  

ERIC Educational Resources Information Center

This instructional package, designed for use in secondary and adult education, focuses on the vocational area of needle trades. Section A of this document contains three units of instruction; "Securing a Job,""Career Success," and "The Free Enterprise System." Section B contains four units on sewn products operations: "Sewing Machine Maintenance…

Halmes, Ellen; Sawatzky, Joyce

186

The Single Needle Lockstitch Machine. Module 1.  

ERIC Educational Resources Information Center

This module on parts of the machine, one in a series on the single needle lockstitch sewing machine for student self-study, contains eight sections. Each section contains the following parts: an introduction, directions, an objective, learning activities, student information, student self-check, check-out activities, and an instructor's final…

South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

187

Presence: the eye of the needle.  

PubMed

This column explores the meanings of presence from philosophical, theological, psychological, and nursing perspectives. The eye of the needle is used as a metaphor to emphasize the capacities required for living presence. The humanbecoming concept of true presence is emphasized and examples are given of living true presence in nursing. PMID:22228515

Bunkers, Sandra Schmidt

2012-01-01

188

Smoking-related idiopathic interstitial pneumonia.  

PubMed

Cigarette smoking is a key factor in the development of numerous pulmonary diseases. An international group of clinicians, radiologists and pathologists evaluated patients with previously identified idiopathic interstitial pneumonia (IIP) to determine unique features of cigarette smoking. Phase 1 (derivation group) identified smoking-related features in patients with a history of smoking (n=41). Phase 2 (validation group) determined if these features correctly predicted the smoking status of IIP patients (n=100) to participants blinded to smoking history. Finally, the investigators sought to determine if a new smoking-related interstitial lung disease phenotype could be defined. Phase 1 suggested that preserved forced vital capacity with disproportionately reduced diffusing capacity of the lung for carbon monoxide, and various radiographic and histopathological findings were smoking-related features. In phase 2, the kappa coefficient among clinicians was 0.16 (95% CI 0.11-0.21), among the pathologists 0.36 (95% CI 0.32-0.40) and among the radiologists 0.43 (95% CI 0.35-0.52) for smoking-related features. Eight of the 100 cases were felt to represent a potential smoking-related interstitial lung disease. Smoking-related features of interstitial lung disease were identified in a minority of smokers and were not specific for smoking. This study is limited by its retrospective design, the potential for recall bias in smoking history and lack of information on second-hand smoke exposure. Further research is needed to understand the relationship between smoking and interstitial lung disease. PMID:25063244

Flaherty, Kevin R; Fell, Charlene; Aubry, Marie-Christine; Brown, Kevin; Colby, Thomas; Costabel, Ulrich; Franks, Teri J; Gross, Barry H; Hansell, David M; Kazerooni, Ella; Kim, Dong Soon; King, Talmadge E; Kitachi, Masanori; Lynch, David; Myers, Jeff; Nagai, Sonoko; Nicholson, Andrew G; Poletti, Venerino; Raghu, Ganesh; Selman, Moises; Toews, Galen; Travis, William; Wells, Athol U; Vassallo, Robert; Martinez, Fernando J

2014-09-01

189

Synthesis, molecular structure and properties of the [H6-nNi30C4(CO)34(CdCl)2]n- (n=3-6) bimetallic carbide carbonyl cluster: a model for the growth of noncompact interstitial metal carbides.  

PubMed

Reaction of the [Ni(9)C(CO)(17)](2-) dianion with CdCl(2)2.5 H(2)O in THF affords the novel bimetallic Ni--Cd carbide carbonyl clusters [H(6-n)Ni(30)C(4)(CO)(34)(micro(5)-CdCl)(2)](n-) (n=3-6), which undergo several protonation-deprotonation equilibria in solution depending on the basicity of the solvent or upon addition of acids or bases. Although the occurrence in solution of these equilibria complicates the pertinent electrochemical studies on their electron-transfer activity, they clearly indicate that the clusters [H(6-n)Ni(30)C(4)(CO)(34)(micro(5)-CdCl)(2)](n-) (n=3-6), as well as the structurally related [H(6-n)Ni(34)C(4)(CO)(38)](n-) (n=4-6), undergo reversible or partially reversible redox processes and provide circumstantial and unambiguous evidence for the presence of hydrides for n=3, 4 and 5. Three of the [H(6-n)Ni(30)C(4)(CO)(34)(micro(5)-CdCl)(2)](n-) anions (n=4-6) have been structurally characterized in their [NMe(3)(CH(2)Ph)](4)[H(2)Ni(30)C(4)(CO)(34)(CdCl)(2)]2 COMe(2), [NEt(4)](5)[HNi(30)C(4)(CO)(34)(CdCl)(2)]2 MeCN and [NMe(4)](6)[Ni(30)C(4)(CO)(34)(CdCl)(2)]6 MeCN salts, respectively. All three anions display almost identical geometries and bonding parameters, probably because charge effects are minimized by delocalization over such a large metal carbonyl anion. Moreover, the Ni(30)C(4) core in these Ni-Cd carbide clusters is identical within experimental error to those present in the [HNi(34)C(4)(CO)(38)](5-) and [Ni(35)C(4)(CO)(39)](6-) species, suggesting that the stepwise assembly of their nickel carbide cores may represent a general pathway of growth of nickel polycarbide clusters. The fact that the [H(6-n)Ni(30)C(4)(CO)(34)(micro(5)-CdCl)(2)](n-)(n=4-6) anions display two valence electrons more than the structurally related [H(6-n)Ni(34)C(4)(CO)(38)](n-) (n=4-6) species has been rationalized by extended Hückel molecular orbital (EHMO) analysis. PMID:18080263

Bernardi, Alessandro; Femoni, Cristina; Iapalucci, Maria Carmela; Longoni, Giuliano; Ranuzzi, Fabrizio; Zacchini, Stefano; Zanello, Piero; Fedi, Serena

2008-01-01

190

Friedel-like Oscillations from Interstitial Iron in Superconducting Fe1+yTe0.62Se0.38  

NASA Astrophysics Data System (ADS)

Using polarized and unpolarized neutron scattering we show that interstitial Fe in superconducting Fe1+yTe1-xSex induces a magnetic Friedel-like oscillation that diffracts at Q=(120) and involves >50 neighboring Fe sites. The interstitial >2 ?B moment is surrounded by compensating ferromagnetic four spin clusters that may seed double stripe ordering in Fe1+yTe. A semi-metallic 5-band model with (1212) Fermi surface nesting and four fold symmetric super-exchange between interstitial Fe and two in-plane nearest neighbors largely accounts for the observed diffraction.

Thampy, Vivek; Kang, J.; Rodriguez-Rivera, J. A.; Bao, W.; Savici, A. T.; Hu, J.; Liu, T. J.; Qian, B.; Fobes, D.; Mao, Z. Q.; Fu, C. B.; Chen, W. C.; Ye, Q.; Erwin, R. W.; Gentile, T. R.; Tesanovic, Z.; Broholm, C.

2012-02-01

191

Quantitative measurement of the surface silicon interstitial boundary condition and silicon interstitial injection into silicon during oxidation  

E-print Network

Quantitative measurement of the surface silicon interstitial boundary condition and silicon interstitial injection into silicon during oxidation M. S. Carroll* and J. C. Sturm Department of Electrical the oxidation of silicon, interstitials are generated at the oxidizing surface and diffuse into the silicon

192

Interstitial lung disease associated with Equine Infectious Anemia Virus infection in horses.  

PubMed

EIA (Equine Infectious Anemia) is a blood-borne disease primarily transmitted by haematophagous insects or needle punctures. Other routes of transmission have been poorly explored. We evaluated the potential of EIAV (Equine Infectious Anemia Virus) to induce pulmonary lesions in naturally infected equids. Lungs from 77 EIAV seropositive horses have been collected in Romania and France. Three types of lesions have been scored on paraffin-embedded lungs: lymphocyte infiltration, bronchiolar inflammation, and thickness of the alveolar septa. Expression of the p26 EIAV capsid (CA) protein has been evaluated by immunostaining. Compared to EIAV-negative horses, 52% of the EIAV-positive horses displayed a mild inflammation around the bronchioles, 22% had a moderate inflammation with inflammatory cells inside the wall and epithelial bronchiolar hyperplasia and 6.5% had a moderate to severe inflammation, with destruction of the bronchiolar epithelium and accumulation of smooth muscle cells within the pulmonary parenchyma. Changes in the thickness of the alveolar septa were also present. Expression of EIAV capsid has been evidenced in macrophages, endothelial as well as in alveolar and bronchiolar epithelial cells, as determined by their morphology and localization. To summarize, we found lesions of interstitial lung disease similar to that observed during other lentiviral infections such as FIV in cats, SRLV in sheep and goats or HIV in children. The presence of EIAV capsid in lung epithelial cells suggests that EIAV might be responsible for the broncho-interstitial damages observed. PMID:24289102

Bolfa, Pompei; Nolf, Marie; Cadoré, Jean-Luc; Catoi, Cornel; Archer, Fabienne; Dolmazon, Christine; Mornex, Jean-François; Leroux, Caroline

2013-01-01

193

Near "real" time magnetic resonance images as a monitoring system for interstitial laser therapy: experimental protocols  

NASA Astrophysics Data System (ADS)

The failure rate of cancer treatment remains unacceptably high, still being a leading cause of mortality in adults and children despite major advances over the past 50 years in the fields of surgery, radiation therapy and, more recently, chemo and immunotherapy. Surgical access to some deep tumors of the head and neck and other areas often require extensive dissections with residual functional and cosmetic deformities. Repeated treatment is not possible after maximum dose radiotherapy and chemotherapy is still limited by its systemic toxicity. An attractive solution to these problems would be the development of a new adjunctive method combining the best features of interstitial laser therapy for selective tumor destruction via minimally invasive techniques for access and 3-D magnetic resonance imaging (MRI) as a monitoring system for laser-tissue interactions. Interstitial laser therapy (ILT) via fiberoptics allow laser energy to be delivered directly into deeper tissues. However, this concept will become clinically useful only when noninvasive, accurate, and reproducible monitoring methods are developed to measure energy delivery to tissues. MRI has numerous advantages in evaluating the irreversible effects of laser treatment in tissues, since laser energy includes changes not only in the thermal motions of hydrogen protons within the tissue, but also in the distribution and mobility of water and lipids. These techniques should greatly improve the use of ILT in combination with MRI to allow treatment of deeper, more difficult to reach tumors of head and neck and other anatomical areas with a single needle stick.

Castro, Dan J.; Farahani, Keyvan; Soudant, Jacques; Zwarun, Andrew A.; Lufkin, Robert B.

1992-06-01

194

Interstitial lung disease associated with Equine Infectious Anemia Virus infection in horses  

PubMed Central

EIA (Equine Infectious Anemia) is a blood-borne disease primarily transmitted by haematophagous insects or needle punctures. Other routes of transmission have been poorly explored. We evaluated the potential of EIAV (Equine Infectious Anemia Virus) to induce pulmonary lesions in naturally infected equids. Lungs from 77 EIAV seropositive horses have been collected in Romania and France. Three types of lesions have been scored on paraffin-embedded lungs: lymphocyte infiltration, bronchiolar inflammation, and thickness of the alveolar septa. Expression of the p26 EIAV capsid (CA) protein has been evaluated by immunostaining. Compared to EIAV-negative horses, 52% of the EIAV-positive horses displayed a mild inflammation around the bronchioles, 22% had a moderate inflammation with inflammatory cells inside the wall and epithelial bronchiolar hyperplasia and 6.5% had a moderate to severe inflammation, with destruction of the bronchiolar epithelium and accumulation of smooth muscle cells within the pulmonary parenchyma. Changes in the thickness of the alveolar septa were also present. Expression of EIAV capsid has been evidenced in macrophages, endothelial as well as in alveolar and bronchiolar epithelial cells, as determined by their morphology and localization. To summarize, we found lesions of interstitial lung disease similar to that observed during other lentiviral infections such as FIV in cats, SRLV in sheep and goats or HIV in children. The presence of EIAV capsid in lung epithelial cells suggests that EIAV might be responsible for the broncho-interstitial damages observed. PMID:24289102

2013-01-01

195

Interstitial thermotherapy with bipolar rf applicators: computer-aided therapy control and monitoring  

NASA Astrophysics Data System (ADS)

A computer simulation of the temperature and damage distribution during a bipolar RFITT (radio-frequency current induced interstitial thermotherapy) application has been developed. The electric field and the heat transfer is calculated by the Finite Difference Method. The program calculates the distribution of electrical power density (heat generating term), temperature and tissue damage using standard and cooled bipolar needle applicators and displays the results graphically in real time. Whereby the changes of the tissue parameters due to the heating process are also taken into account. The computer program can not only be a means for therapy planning but as well for on-line therapy control. For this the program has the option to measure the output power of the RF-surgery generator and the tissue impedance via an A/D-converter. This gives more accurate simulation results. Furthermore the power output of the RF- generator can be controlled by the program via a D/A- converter. The option of measuring and steering the generator power allows the possible implementation of various control algorithms with the aim of performing an interstitial coagulation with high efficiency.

Stein, Thomas; Desinger, Kai; Roggan, Andre; Mueller, Gerhard J.

1999-01-01

196

Impact of pine needle leachates from a mountain pine beetle infested watershed on groundwater geochemistry  

NASA Astrophysics Data System (ADS)

The mountain pine beetle (MPB) epidemic in the northwestern United States is a recent indicator of climate change; having an impact on the lodgepole pine forest ecosystem productivity. Pine needle color can be used to predict the stage of a MPB infestation, as they change color from a healthy green, to red, to gray as the tree dies. Physical processes including precipitation and snowfall can cause leaching of pine needles in all infestation stages. Understanding the evolution of leachate chemistry through the stages of MPB infestation will allow for better prediction of the impact of MPBs on groundwater geochemistry, including a potential increase in soil metal mobilization and potential increases in disinfection byproduct precursor compounds. This study uses batch experiments to determine the leachate chemistry of pine needles from trees in four stages of MPB infestation from Summit County, CO, a watershed currently experiencing the MPB epidemic. Each stage of pine needles undergoes four subsequent leach periods in temperature-controlled DI water. The subsequent leaching method adds to the experiment by determining how leachate chemistry of each stage changes in relation to contact time with water. The leachate is analyzed for total organic carbon. Individual organic compounds present in the leachate are analyzed by UV absorption spectra, fluorescence spectrometry, high-pressure liquid chromatography for organic acid analysis, and size exclusion chromatography. Leachate chemistry results will be used to create a numerical model simulating reactions of the leachate with soil as it flows through to groundwater during precipitation and snowfall events.

Pryhoda, M.; Sitchler, A.; Dickenson, E.

2013-12-01

197

Use of transrectal ultrasound for high dose rate interstitial brachytherapy for patients of carcinoma of uterine cervix  

PubMed Central

Objective Transrectal ultrasound (TRUS) has been widely used for guiding prostate implants, but not much for interstitial brachytherapy (IBT) of cervix cancer. The aim of our study is to report our experience with TRUS guided high dose rate (HDR) IBT in patients with carcinoma of uterine cervix. Methods During the year 2005-2006, 25 patients of cervical cancer not suitable for intracavitary radiotherapy (ICRT), were enrolled in this prospective study. We used B-K Medical USG machine (Falcon 2101) equipped with a TRUS probe (8658) having a transducer of 7.5 MHz for IBT. Post procedure, a CT scan was done for verification of needle position and treatment planning. Two weekly sessions of HDR IBT of 8-10 Gy each were given after pelvic external beam radiation therapy. Results A total of 40 IBT procedures were performed in 25 patients. Average duration of implant procedure was 50 minutes. There was no uterine perforation in any of 11 patients in whom central tandem was used. CT scan did not show needle perforation of bladder/rectum in any of the patients. During perioperative period, only 1 procedure (2.5%) was associated with hematuria which stopped within 6 hours. Severe late toxicity was observed in 3 (12%) patients. Overall pelvic control rate was 64%. Conclusion Our experience suggests that TRUS is a practical and effective imaging device for guiding the IBT procedure of cervical cancer patients. It helps in accurate placements of needles thus avoiding the injury to normal pelvic structures. PMID:20379442

Rath, Goura Kisor; Thulkar, Sanjay; Kumar, Sunesh; Subramani, Vellaiyan; Julka, Parmod Kumar

2010-01-01

198

The hard metal diseases  

SciTech Connect

Hard metal is a mixture of tungsten carbide and cobalt, to which small amounts of other metals may be added. It is widely used for industrial purposes whenever extreme hardness and high temperature resistance are needed, such as for cutting tools, oil well drilling bits, and jet engine exhaust ports. Cobalt is the component of hard metal that can be a health hazard. Respiratory diseases occur in workers exposed to cobalt--either in the production of hard metal, from machining hard metal parts, or from other sources. Adverse pulmonary reactions include asthma, hypersensitivity pneumonitis, and interstitial fibrosis. A peculiar, almost unique form of lung fibrosis, giant cell interstitial pneumonia, is closely linked with cobalt exposure.66 references.

Cugell, D.W. (Department of Medicine, Northwestern University Medical School, Chicago, IL (United States))

1992-06-01

199

Basic technique in endoscopic ultrasound-guided fine needle aspiration for solid lesions: What needle is the best?  

PubMed Central

Basic technique for endoscopic ultrasound (EUS) of solid lesions has developed during 30 years of EUS, as endoscopes and accessory equipment, particularly needles, have been developed. Systematic high-quality examinations require understanding and planning. Needles used for EUS-guided fine needle aspiration (FNA) have gone through many improvements; some 18 characteristics of any needle are presented and these come under consideration whenever choosing the best needle for each procedure. The bright future of EUS and FNA for solid lesions currently still leaves much room for continued developments. PMID:24949410

Lachter, Jesse

2014-01-01

200

Interstitial devices for treating deep seated tumors  

NASA Astrophysics Data System (ADS)

Techniques using intracavitary or interstitial applicators have been proposed because extracorporeal HIFU techniques are not always suitable for deep-seated tumors. Bones or gaseous pockets may indeed be located in the intervening tissue. The objective is to bring the ultrasound source as close as possible to the target through natural routes in order to minimize the effects of attenuation and phase aberration along the ultrasound pathway. Under these circumstances, it becomes possible to use higher frequency, thus increasing the ultrasonic absorption coefficient and resulting in more efficient heating of the treatment region. In contrast to extra-corporeal applicators, the design of interstitial probes imposes additional constraints relative to size and ergonomy. The goal of this paper is to present the range of miniature interstitial applicators we developed at INSERM for various applications. The sources are rotating plane water-cooled transducers that operate at a frequency between 3 and 10 MHz depending on the desired therapeutic depth. The choice of a plane transducer rather than divergent sources permits to extend the therapeutic depth and to enhance the angular selectivity of the treatment Rotating single element flat transducer can also be replaced by cylindrical arrays for rotating electronically a reconstructed plane wave. When extended zone of coagulation are required, original therapeutic modalities combining cavitation and thermal effects are used. These methods consist in favoring in depth heating by increasing the acoustic attenuation away from the transducer with the presence of bubbles. When associated to modern imaging modalities, these minimally invasive therapeutic devices offer very promising options for cancer treatment. For examples, two versions of an image-guided esophageal applicator are designed: one uses a retractable ultrasound mini probe for the positioning of the applicator, while the other is MRI compatible and offers on line monitoring of temperature. Beyond these engineering considerations, our clinical experience demonstrates that following interstitial routes for applying HIFU is an interesting therapeutic option when targeted sites cannot be reached from outside the patient.

Lafon, Cyril; Cathignol, Dominique; Prat, Frédéric; Melodelima, David; Salomir, Rares; Theillère, Yves; Chapelon, Jean-Yves

2006-05-01

201

Giant cell interstitial pneumonia associated with nitrofurantoin.  

PubMed

A case of giant cell interstitial pneumonia (GIF) that occurred in association with exposure to nitrofurantoin is presented. While the diagnosis of GIP is confirmed by histopathology, this diagnosis can be supported by the findings of bizarre multinucleated giant cells (MGC), elevated T lymphocytes, and a low T lymphocyte helper/suppressor ratio in the bronchoalveolar lavage fluid (BALF). Recognition of GIP as a rare manifestation of nitrofurantoin toxicity is important because prompt therapy may be associated with a favorable outcome. PMID:16902839

Hargett, Charles William; Sporn, Thomas A; Roggli, Victor L; Hollingsworth, John W

2006-01-01

202

Giant Cell Interstitial Pneumonia Associated with Nitrofurantoin  

Microsoft Academic Search

A case of giant cell interstitial pneumonia (GIF) that occurred in association with exposure to nitrofurantoin is presented.\\u000a While the diagnosis of GIP is confirmed by histopathology, this diagnosis can be supported by the findings of bizarre multinucleated\\u000a giant cells (MGC), elevated T lymphocytes, and a low T lymphocyte helper\\/suppressor ratio in the bronchoalveolar lavage fluid\\u000a (BALF). Recognition of GIP

Charles William Hargett; Thomas A. Sporn; Victor L. Roggli; John W. Hollingsworth

2006-01-01

203

Polymyositis-dermatomyositis-associated interstitial lung disease.  

PubMed

We report findings in 70 patients with both diffuse interstitial lung disease and either polymyositis (PM) or dermatomyositis (DM). Initial presentations were most commonly either musculoskeletal (arthralgias, myalgias, and weakness) or pulmonary (cough, dyspnea, and fever) symptoms alone; in only 15 patients (21.4%) did both occur simultaneously. Pulmonary disease usually took the form of acute to subacute antibiotic-resistant community-acquired pneumonia. Chest radiographs and computed tomography most commonly demonstrated bilateral irregular linear opacities involving the lung bases; occasionally consolidation was present. Jo-1 antibody was present in 19 (38%) of 50 patients tested. Synchronous associated malignancy was present in 4 of 70 patients (5.7%). Surgical lung biopsies disclosed nonspecific interstitial pneumonia (NSIP) in 18 of 22 patients (81.8%), organizing diffuse alveolar damage (DAD) in 2, bronchiolitis obliterans organizing pneumonia (BOOP) in 1, and usual interstitial pneumonia (UIP) in 1. Treatment usually included prednisone in 40-60 mg/d dosages for initial control, followed by lower dose prednisone plus an immunosuppressive agent such as azathioprine or methotrexate for disease suppression. Survival was significantly better than that observed for historical control subjects with idiopathic UIP, and was more consistent with survival previously reported in idiopathic NSIP. There was no difference in survival between Jo-1 positive and Jo-1 negative groups. PMID:11673206

Douglas, W W; Tazelaar, H D; Hartman, T E; Hartman, R P; Decker, P A; Schroeder, D R; Ryu, J H

2001-10-01

204

Breast conservation treatment with perioperative interstitial irradiation  

SciTech Connect

Limited resection of the breast combined with radiation has proved to be as effective as more radical surgery in treating early breast cancer. At the University of Kansas Medical Center, the radiotherapy consists of an interstitial implant at the time of lumpectomy to deliver an interstitial boost dose to the tumor bed with iridium-192 immediately following the surgical procedure. An axillary node dissection is also performed at the time of lumpectomy. A dose of 2000 cGy is delivered to the tumor bed between 40 and 60 h. Two to three weeks later, 4500-5000 cGy is delivered to the entire breast with external beam radiation over 5-5.5 weeks. One hundred breasts in 98 patients were so treated between June 1982 and February 1986, with 2 carcinomas in situ, 40 stage I, 51 stage II, and 7 stage III cancers, consisting of 2 TIS, 54 T1, 39 T2, and 5 T3 lesions. Locoregional control with a median follow-up of 31 months was 98%. One recurrence was in a different quadrant, and the other revealed predominantly the in situ component. Immediate implant did not compromise wound healing or cosmesis. The cosmetic result was graded as good to excellent in 88% of the breasts. Our preliminary results appear to suggest a better local control with immediate interstitial irradiation.

Krishnan, L.; Mansfield, C.M.; Jewell, W.R.; Reddy, E.K.; Thomas, J.H.; Krishnan, E.C.

1987-10-01

205

Dynamics of translational friction in needle-tissue interaction during needle insertion.  

PubMed

In this study, a distributed approach to account for dynamic friction during needle insertion in soft tissue is presented. As is well known, friction is a complex nonlinear phenomenon. It appears that classical or static models are unable to capture some of the observations made in systems subjected to significant frictional effects. In needle insertion, translational friction would be a matter of importance when the needle is very flexible, or a stop-and-rotate motion profile at low insertion velocities is implemented, and thus, the system is repeatedly transitioned from a pre-sliding to a sliding mode and vice versa. In order to characterize friction components, a distributed version of the LuGre model in the state-space representation is adopted. This method also facilitates estimating cutting force in an intra-operative manner. To evaluate the performance of the proposed family of friction models, experiments were conducted on homogeneous artificial phantoms and animal tissue. The results illustrate that our approach enables us to represent the main features of friction which is a major force component in needle-tissue interaction during needle-based interventions. PMID:23963885

Asadian, Ali; Patel, Rajni V; Kermani, Mehrdad R

2014-01-01

206

Electrotactile display using microfabricated micro-needle array  

NASA Astrophysics Data System (ADS)

This paper describes an electrotactile display with micro-needle electrodes. The electrotactile display can produce tactile sensations by stimulating tactile receptors using an electric current. Micro-needle electrodes can drastically decrease the threshold voltage required to stimulate tactile receptors by penetrating the stratum corneum, which has a higher impedance than the dermis. In addition, the optimized length of the needle allows us to stimulate tactile receptors painlessly. In the present study, we developed a process for fabricating a micro-needle array in which the length and tip radius can be controlled using electrochemical etching. A micro-needle array was successfully fabricated to form an electrotactile display. In addition, we experimentally determined the suitable shape of the micro-needle electrodes for electrotactile display applications. When the tip radius of the needle is too small, the impedance between the finger and micro-needles becomes large due to the small contact area. On the other hand, when the tip radius is too large, the needle cannot penetrate the skin surface and the impedance is not sufficiently small. The experiments verified the superiority of needle electrode devices to flat electrode devices with respect to the threshold voltage at each frequency.

Kitamura, N.; Chim, J.; Miki, N.

2015-02-01

207

Interstitial space and collagen alterations of the developing rat diaphragm  

NASA Technical Reports Server (NTRS)

The effect of growth on the relative interstitial space [%total cross-sectional area (CSA)] and collagen content of the rat diaphragm muscle was examined at postnatal ages of 0, 7, 14, and 21 days as well as in adult males. The proportion of interstitial space relative to total muscle CSA was determined by computerized image analysis of lectin-stained cross sections of diaphragm muscle. To assess collagen content and extent of collagen maturation (i.e., cross-linking), high-pressure liquid chromatography analysis was used to measure hydroxyproline concentration and the nonreducible collagen cross-link hydroxylysylpyridinoline (HP), respectively. At birth, interstitial space accounted for approximately 47% of total diaphragm muscle CSA. During postnatal growth, the relative contribution of interstitial space decreased such that by adulthood the interstitial space accounted for approximately 18% of total muscle CSA. The change in relative interstitial space occurred without a concomitant change in hydroxyproline concentration. However, the concentration of HP markedly increased with age such that the adult diaphragm contained approximately 17 times more HP than at birth. These results indicate that during development the relative CSA occupied by interstitial space decreases as muscle fiber size increases. However, the reduction in relative interstitial space is not associated with a change in collagen concentration. Thus collagen density in the interstitial space may increase with age. It is possible that the observed changes in relative interstitial space and collagen influence the passive length-force properties of the diaphragm.

Gosselin, L. E.; Martinez, D. A.; Vailas, A. C.; Sieck, G. C.

1993-01-01

208

Usual interstitial pneumonia coexisted with nonspecific interstitial pneumonia, What’s the diagnosis?  

PubMed Central

The differential diagnosis between idiopathic nonspecific interstitial pneumonia(INSIP) and idiopathic pulmonary fibrosis(IPF)/usual interstitial pneumonia(UIP)is tough in both clinicians and pathologists. In this study, we analyzed the lesions of right lung removed from a 58-year-old patient by gross and microscopy. The results showed that the pathological appearance of nonspecific interstitial pneumonia (NSIP) and UIP coexisted in his upper lobe. Besides, because of severe fibrosis in middle and lower lobes, it was hard to distinguish the lesions of NSIP fibrotic pattern (NSIP-F) or UIP. Based on clinic-radiologic-pathological data, the diagnosis of INSIP-F was made for this patient finally. Our study suggests that UIP is not always an accurate diagnosis when the NSIP and UIP coexist, and NSIP can have regions of UIP. Virtual slide The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2573531681608730 PMID:23206520

2012-01-01

209

The effect of needle dimensions and infusion rates on injection pressures in regional anaesthesia needles: a bench-top study.  

PubMed

Animal studies have shown that injection pressures > 75 kPa indicate probable intrafascicular needle tip position. This study describes the flow/pressure characteristics of seven common needle systems. A syringe pump delivered flow rates of 5, 6.67, 10, 13.3, 15 and 20 ml.min(-1) through these needle systems, while keeping the needle tips open to atmosphere. A pressure transducer connected between the syringe and needle provided a real-time graphical display for analysis. Mean plateau pressures increased linearly with flow and with decreasing needle diameter (2.7-92 kPa). Flow rates > 17 ml.min(-1) and needle sizes 22 G and smaller produced mean plateau pressures > 75 kPa. Pressure monitors upstream from the needle may produce false-positive alarms at high flow rates due to needle resistance, and unreliable readings due to non-laminar flow. We recommend injection rates ? 15 ml.min(-1) (0.25 ml.s(-1) ) to reduce the effect of factors upstream from the needle tip as a cause of high pressure readings. PMID:25290190

Patil, J J; Ford, S; Egeler, C; Williams, D J

2015-02-01

210

Wavelength shifts in fluorescence maxima of stressed and non-stressed Norway spruce needles over the growing season  

NASA Technical Reports Server (NTRS)

Laboratory fluorescence measurements of first and third year metal stressed and non stressed Norway spruce needles collected in May, Jul. Sep. and Nov. display significant wavelength shifts in the intensity maxima in the blue, green, red, and near infrared spectral regions, with the largest shifts occurring in the blue spectral region for both first and third year needles from Nov. Smaller, but the otherwise significant shifts also take place in the blue spectral region for first year needles from Sep. in the red spectral region for third year neddles from May, Jul. and Sep. and in the near infrared spectral region for first and third year needles from Jul. and Sep. Wavelength shifts in needle fluorescence maxima over the growing season are greatest in the blue and to a lesser extent, greenspectral regions from Sep. to Nov. but are also significant in the red and near infrared spectral regions from Jul. to Sep. and Sep. to Nov., and in the near infrared spectral region also from May to Jul.

Banninger, Cliff; Chappelle, E.

1991-01-01

211

Chest Wall Dissemination of Nocardiosis after Percutaneous Transthoracic Needle Biopsy  

SciTech Connect

We described a case of chest wall dissemination after percutaneous transthoracic needle biopsy. A 65-year-old man had a lung nodule which was suspected to be lung carcinoma. He underwent percutaneous transthoracic needle biopsy using an 18G semiautomated biopsy needle and pathologic diagnosis showed organizing pneumonia. Two months after the biopsy, chest wall dissemination occurred. Implantation of carcinoma along the biopsy route was suspected, but the mass was actually due to pulmonary nocardiosis.

Shimamoto, Hiroshi, E-mail: hshima@k8.dion.ne.jp; Inaba, Yoshitaka; Yamaura, Hidekazu; Sato, Yozo; Kamiya, Mika; Miyazaki, Masaya [Achi Cancer Center, Department of Diagnostic and Interventional Radiology (Japan); Arai, Yasuaki [National Cancer Center, Department of Diagnostic and Interventional Radiology (Japan); Horio, Yoshitsugu [Achi Cancer Center, Department of Thoracic Oncology (Japan)

2007-07-15

212

Interstitial Ti for intermediate band formation in Ti-supersaturated silicon  

NASA Astrophysics Data System (ADS)

We have analyzed by means of Rutherford backscattering spectrometry (RBS) the Ti lattice location and the degree of crystalline lattice recovery in heavily Ti implanted silicon layers subsequently pulsed laser melted (PLM). Theoretical studies have predicted that Ti should occupy interstitial sites in silicon for a metallic-intermediate band (IB) formation. The analysis of Ti lattice location after PLM processes is a crucial point to evaluate the IB formation that can be clarifyied by means of RBS measurements. After PLM, time-of-flight secondary ion mass spectrometry measurements show that the Ti concentration in the layers is well above the theoretical limit for IB formation. RBS measurements have shown a significant improvement of the lattice quality at the highest PLM energy density studied. The RBS channeling spectra reveals clearly that after PLM processes Ti impurities are mostly occupying interstitial lattice sites.

Pastor, D.; Olea, J.; Muñoz-Martín, A.; Climent-Font, A.; Mártil, I.; González-Díaz, G.

2012-12-01

213

Occult connective tissue diseases mimicking idiopathic interstitial pneumonias.  

PubMed

In patients with interstitial lung disease (ILD), the diagnosis of idiopathic interstitial pneumonia is usually made after excluding, among other conditions, connective tissue diseases (CTDs). Although in most patients with a CTD and respiratory symptoms, the systemic nature of the disease is obvious, the ILD-related manifestations in CTDs may often dominate the clinical picture or precede systemic findings and thus mimic idiopathic interstitial pneumonia. With the exception of systemic lupus erythematosus, all CTDs may imitate chronic idiopathic interstitial pneumonias. In this setting, clues to an underlying CTD may be entirely absent or include subtle findings from various systems, including skin, vascular and musculoskeletal system or internal organs. Since nonspecific interstitial pneumonia is a relatively frequent histological pattern in CTDs, biopsy reports of nonspecific interstitial pneumonia should also prompt a search for an underlying CTD. Ultimately, diagnosis of a CTD requires confirmation with immunological testing; interpretation of the various laboratory tests should always be carried out in conjunction with clinical findings. The present article reviews specific clinical aspects of connective tissue disease-related interstitial lung disease that may help differentiate it from idiopathic interstitial pneumonia, especially when interstitial lung disease is the predominant or sole manifestation of an occult connective tissue disease. PMID:18166591

Tzelepis, G E; Toya, S P; Moutsopoulos, H M

2008-01-01

214

Idiopathic desquamative interstitial pneumonia in a child: a case report  

PubMed Central

Background Desquamative interstitial pneumonia is a rare form of interstitial lung disease in children. Respiratory symptoms appear progressively, are often subtle, and diagnosis is often delayed by a mean of 6 months after onset. High resolution chest computed tomography is the most sensitive imaging technique for demonstrating and identifying interstitial pneumonia. The typical histologic pattern of desquamative interstitial pneumonia, with prominent clustered alveolar macrophages, diffuse reactive alveolar epithelial hyperplasia and globular proteinaceous material, is diagnostic. Desquamative interstitial pneumonia in children can be idiopathic, though it is mostly related to an inborn error of surfactant metabolism. Case presentation We present the complex clinical course and pathologic findings of a 30-months-old Mauritian and Senegalese girl with idiopathic desquamative interstitial pneumonia and multiple extrapulmonary manifestations. To our knowledge, this is the first case report of desquamative interstitial pneumonia to occur as part of a syndrome with multiple organ involvement. Conclusion We believe that desquamative interstitial pneumonia is not always associated with mutations of the surfactant proteins, and can still be idiopathic, especially when occurring as part of a syndrome with multiple organ involvement, as described in other interstitial lung diseases. PMID:24954625

2014-01-01

215

21 CFR 890.1385 - Diagnostic electromyograph needle electrode.  

Code of Federal Regulations, 2010 CFR

...DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Diagnostic Devices § 890.1385 Diagnostic electromyograph needle electrode. (a)...

2010-04-01

216

21 CFR 890.1385 - Diagnostic electromyograph needle electrode.  

Code of Federal Regulations, 2011 CFR

...DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Diagnostic Devices § 890.1385 Diagnostic electromyograph needle electrode. (a)...

2011-04-01

217

The biopolitics of needle exchange in the United States  

PubMed Central

Needle exchange began in the United States as a fragmented and illegal practice initiated by actors at the grassroots level; since the late 1980s, needle exchange has achieved increasing yet variable levels of institutional support across the country, receiving official sanction and funding from state and municipal governments. In turn, the practice(s) and discourse(s) of needle exchange have shifted significantly in many locales, becoming the purview of professional administration that advocates needle exchange as a necessary public health measure. This article is interested in the ways in which needle exchange has become implicated in and appropriated by networks of power seeking to discipline and regulate injection drug use. Drawing theoretically on Michel Foucault’s writings concerning biopower and governmentality, it will examine the proliferation of discourses, knowledges, and rules surrounding needle exchange in the United States. At the same time, this article will avoid a characterization of needle exchange that envisions the unilateral control of drug users by governmental power, illuminating instead both its negative and productive effects for drug users. Namely, it will explore how needle exchange creates both subjects of interest and subjects of resistance among drug users – that is to say, the governmentalization of needle exchange and its ‘clients’. PMID:22389572

McLean, Katherine

2012-01-01

218

Collagen gene expression in radiation interstitial pneumonitis  

SciTech Connect

By using type I and type III collagen cDNA probe and cDNA-mRNA in situ hybridization, we observed the changes of rat lung {alpha} 1(I) and {alpha} 1(III) collagen gene expression in radiation interstitial pneumonitis. The results showed that the expressed cell of type I and type III collagen were scattered within the fibroblasts in the thickened interalveolar walls. The type I and type III collagen mRNA content in irradiated animals were higher than those in the controls at 0.5, 1, 2, 3, 6, and 12 months. 10 refs., 4 figs., 1 tab.

Bai Yun-hong; Wang, De-wen; Cui Cai-bin [Institute of Radiation Medicine, Beijing (China)] [and others

1994-12-31

219

Interstitial gas effect on vibrated granular columns  

NASA Astrophysics Data System (ADS)

Vibrated granular materials have been intensively used to investigate particle segregation, convection, and heaping. We report on the behavior of a column of heavy grains bouncing on an oscillating solid surface. Measurements indicate that, for weak effects of the interstitial gas, the temporal variations of the pressure at the base of the column are satisfactorily described by considering that the column, despite the observed dilation, behaves like a porous solid. In addition, direct observation of the column dynamics shows that the grains of the upper and lower surfaces are in free fall in the gravitational field and that the dilation is due to a small delay between their takeoff times.

Pastenes, Javier C.; Géminard, Jean-Christophe; Melo, Francisco

2014-06-01

220

The role of temeperature redistribution of interstitial atoms in the ordering of FCC substitutional-interstitial binary alloys  

Microsoft Academic Search

Within the framework of a model of noninteracting interstitial atoms the effect of their temperature redistribution between\\u000a different interstices on the ordering pattern is investigated in fcc substitutional-interstitial alloys. It is shown that,\\u000a due to the interstitial component, ordering is possible even in systems with negative ordering energy. The types of the order-disorder\\u000a phase transition are studied in terms of

V. A. Volkov; G. S. Masharov; S. I. Masharov

2006-01-01

221

Ultrafine hollow needle formation on silicon  

NASA Astrophysics Data System (ADS)

A method for the formation of ultrafine hollow needles, microcylindrical and nano-wall structures on silicon substrates is reported. The fabrication of these ultrafine structures is possible through a combination of high-precision high aspect ratio vertical etching of silicon with a small angle vacuum deposition technique where nanometric walls are feasible. These structures can be used as the media to transfer gas and liquid through their tiny holes. In addition, the structure has been used to realize cavity-based capacitance inclination sensor suitable for small angle detection. A capacitance variation of 0.6 pF/degree of inclination has been obtained.

Sanaee, Z.; Mohajerzadeh, S.

2010-04-01

222

Systematic Review of the Effectiveness of Fine-Needle Aspiration and/or Core Needle Biopsy for Subclassifying Lymphoma.  

PubMed

Context .- The World Health Organization system for lymphoma classification relies on histologic findings from excisional biopsies. In contradistinction to expert guidelines, practitioners increasingly rely on fine-needle aspiration cytology and core needle biopsies rather than excisional biopsies to diagnose lymphomas. Objective .- To determine a rate at which fine-needle aspiration cytology and core needle biopsies, combined with flow cytometry and/or genetic techniques, can provide a diagnosis sufficient for optimal medical management of lymphoma. Data Sources .- The English-language literature on fine-needle aspiration cytology and core needle biopsies for lymphoma was reviewed to identify studies that provided interpretations of all specimens regardless of whether these were deemed diagnostic. Conclusions .- Forty-two studies (1989-2012) specified the lymphoma subtypes for each diagnosis or indicated a rate at which the methods failed to provide a diagnosis. The median rate at which fine-needle aspiration cytology and core needle biopsies yielded a subtype-specific diagnosis of lymphoma was 74%. Strictly adhering to expert guidelines, which state that follicular lymphoma cannot be graded by these techniques, decreased the diagnostic yield further to 66%. Thus, 25% to 35% of fine-needle aspirates and/or core biopsies of nodes must be followed by an excisional lymph node biopsy to fully classify lymphoma. PMID:25611108

Frederiksen, John K; Sharma, Meenal; Casulo, Carla; Burack, W Richard

2015-02-01

223

Interstitial Fe in MgO  

SciTech Connect

Isolated {sup 57}Fe atoms were studied in MgO single-crystals by emission Mössbauer spectroscopy following implantation of {sup 57}Mn decaying to {sup 57}Fe. Four Mössbauer spectral components were found corresponding to different Fe lattice positions and/or charge states. Two components represent Fe atoms substituting Mg as Fe{sup 2+} and Fe{sup 3+}, respectively; a third component is due to Fe in a strongly implantation-induced disturbed region. The fourth component, which is the focus of this paper, can be assigned to Fe at an interstitial site. Comparison of its measured isomer shift with ab initio calculations suggests that the interstitial Fe is located on, or close to, the face of the rock-salt MgO structure. To harmonize such an assignment with the measured near-zero quadrupole interaction a local motion process (cage motion) of the Fe has to be stipulated. The relation of such a local motion as a starting point for long range diffusion is discussed.

Mølholt, T. E., E-mail: tem4@hi.is; Gislason, H. P.; Ólafsson, S. [Science Institute, University of Iceland, Dunhaga 3, IS-107 Reykjavík (Iceland); Mantovan, R. [Laboratorio MDM, IMM-CNR, Via Olivetti 2, 20846 Agrate Brianza (MB) (Italy); Gunnlaugsson, H. P.; Svane, A.; Weyer, G. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Masenda, H.; Naidoo, D. [School of Physics, University of the Witwatersrand, WITS 2050 (South Africa); Bharuth-Ram, K. [Durban University of Technology, Durban 4001 (South Africa); Fanciulli, M. [Laboratorio MDM, IMM-CNR, Via Olivetti 2, 20846 Agrate Brianza (MB) (Italy); Dipartimento di Scienza dei Materiali, Università di Milano Bicocca, Milano (Italy); Johnston, K. [PH Department, ISOLDE/CERN, 1211 Geneva 23 (Switzerland); Langouche, G. [Instituut voor Kern-en Stralings fysika, University of Leuven, B-3001 Leuven (Belgium); Sielemann, R. [Helmholtz-Zentrum-Berlin für Materialien und Energie, D-14109 Berlin (Germany)

2014-01-14

224

Interstitial oxygen in germanium and silicon  

SciTech Connect

The microscopic structure of interstitial oxygen in germanium and its associated dynamics are studied both experimentally and theoretically. The infrared absorption spectrum is calculated with a dynamical matrix model based on first-principles total-energy calculations describing the potential energy for the nuclear motions. Spectral features and isotope shifts are calculated and compared with available experimental results. From new spectroscopic data on natural and on quasimonoisotopic germanium samples, new isotope shifts have been obtained and compared with the theoretical predictions. The low-energy spectrum is analyzed in terms of a hindered rotor model. A fair understanding of the center is achieved, which is then compared with interstitial oxygen in silicon. The oxygen atom is nontrivially quantum delocalized both in silicon and in germanium, but the physics is shown to be very different: while the Si-O-Si quasimolecule is essentially linear, the Ge-O-Ge structure is puckered. The delocalization in a highly anharmonic potential well of oxygen in silicon is addressed using path-integral Monte Carlo simulations, for comparison with the oxygen rotation in germanium. The understanding achieved with this new information allows us to explain the striking differences between both systems, in both the infrared and the far-infrared spectral regions, and the prediction of the existence of hidden vibrational modes, never directly observed experimentally, but soundly supported by the isotope-shift analysis. {copyright} {ital 1997} {ital The American Physical Society}

Artacho, E.; Yndurain, F. [Instituto Nicolas Cabrera and Departamento de Fisica de la Materia Condensada, C-III Universidad Autonoma de Madrid, 28049 Madrid (Spain)] [Instituto Nicolas Cabrera and Departamento de Fisica de la Materia Condensada, C-III Universidad Autonoma de Madrid, 28049 Madrid (Spain); Pajot, B. [Groupe de Physique des Solides (Unite Associee au CNRS), Tour 23, Universite Denis Diderot, 2 Place Jussieu, 75251 Paris Cedex 05 (France)] [Groupe de Physique des Solides (Unite Associee au CNRS), Tour 23, Universite Denis Diderot, 2 Place Jussieu, 75251 Paris Cedex 05 (France); Ramirez, R.; Herrero, C.P. [Instituto de Ciencia de Materiales, Consejo Superior de Investigaciones Cientificas, Cantoblanco, 28049 Madrid (Spain)] [Instituto de Ciencia de Materiales, Consejo Superior de Investigaciones Cientificas, Cantoblanco, 28049 Madrid (Spain); Khirunenko, L.I. [Institute of Physics, National Academy of Sciences of Ukraine, Prospect Nauki 46, 252650 Kiev 22 (Ukraine)] [Institute of Physics, National Academy of Sciences of Ukraine, Prospect Nauki 46, 252650 Kiev 22 (Ukraine); Itoh, K.M. [Department of Applied Physics and Physico-Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan)] [Department of Applied Physics and Physico-Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan); Haller, E.E. [Lawrence Berkeley National Laboratory and University of California, Berkeley, California 94720 (United States)] [Lawrence Berkeley National Laboratory and University of California, Berkeley, California 94720 (United States)

1997-08-01

225

Sm2Fe17 interstitial magnets (invited)  

NASA Astrophysics Data System (ADS)

Various processing routes for making permanent magnets based on interstitially modified Sm2Fe17 have been recently developed. Zn bonding of coarse grained Sm2Fe17N3 gives coercivities ?0JHc as high as 2.2 T. Effective methods to prepare highly coercive Sm2Fe17N3 powders for polymer bonding are mechanical alloying and rapid quenching. With the very simple method of additional milling of coarse grained nitrided powders we achieved ?0JHc?1.5 T. A coercivity up to 3.5 T has been achieved by a modified HDDR procedure, reducing the particle size of the starting material by milling prior to the hydrogenation-disproportionation-desorption-recombination (HDDR) treatment. This is attributed to a better control of two critical parameters, namely grain size and the amount of unrecombined ?-Fe accompanying the intermediate TbCu7 structure-type phase. Resin bonded HDDR-Sm2Fe17N3 magnets show an unexpected high initial susceptibility. This may be due to a strong magnetic interaction of the grains. To develop coercivity in Sm2Fe17Cy?1 obtained by gas-solid reactions of Sm2Fe17 the same methods as those applied to Sm2Fe17N3 can be successfully used. Fully dense magnets with a coercivity up to 1.5 T were made from the interstitially as well as substitutionally modified compound Sm2Fe15Ga2C2 by hot pressing of highly coercive powders.

Müller, K.-H.; Cao, Lei; Dempsey, N. M.; Wendhausen, P. A. P.

1996-04-01

226

Design of a robust, intuitive piston interface for a needle free injection system  

E-print Network

The MIT BioInstrumentation Lab's linear Lorentz force actuator based needle free injection system has been shown to have numerous benefits over needle-based and other needle-free drug delivery systems in a research ...

Nawrot, Michael Thomas

2014-01-01

227

Development and application of needle trap devices.  

PubMed

Needle trap devices (NTDs), like solid-phase microextraction (SPME) fibers, represent a new approach to one-step, solvent-free sample preparation and injection. New NTDs, packed with divinylbenzene (DVB) or Carboxen 1000 particles, are prepared, characterized, and used for benzene, toluene, ethylbenzne, and xylene (BTEX) sampling in our laboratory. This paper describes optimization parameters, performance evaluation, and application of NTDs for the analysis of a BTEX mixture from air. For active sampling, a sampling flow rate is an essential optimization parameter. Using a very small amount of sorbent particles (less than 1mg DVB or Carboxen), 1.9 mL/min was the highest sampling flow rate that could be used with no breakthrough of any BTEX components. A single NTD was used to study breakthrough volumes (BTVs) and the breakthrough volume was proportional to the quantity of sorbent packed inside the needle. The Carboxen-packed NTD showed higher BTVs for all BTEX compared to the DVB-packed NTD. The performance of home-made NTDs was evaluated at different sampling flow rates, storage times, and for reusability. Finally, DVB packed NTDs were used to sample and analyze a BTEX mixture from permanent marker fumes, mosquito coil smoke, and at various points in the interior of a house. A very low concentration (10 pg/mL) of toluene was detected in the garage. PMID:18355830

Eom, In-Yong; Tugulea, Anca-Maria; Pawliszyn, Janusz

2008-07-01

228

Cryosurgery and needle ablation of renal lesions.  

PubMed

Laparoscopic renal cryoablation is a minimally invasive alternative for treating renal tumors utilizing narrow probes cooled with a compressed gas such as argon or carbon dioxide. At this time, cryotherapy has shown the most promise as an alternative to partial nephrectomy as a nephron-sparing treatment for renal tumors. Radiofrequency ablation employs needle electrodes placed percutaneously directly into renal lesions to deliver energy, creating high temperatures leading to cell death. High-intensity focused ultrasound is a noninvasive technique in which focused ultrasound energy is applied to cause cell death within the focal zone. Microwave thermotherapy uses small applicators to deliver microwave energy to tissues, resulting in the generation of heat. Although RF, HIFU, and microwave thermotherapy show promise as energy sources for tumor ablation, they are in the early stages of development. Little is known about their acute and chronic histologic effects and long-term efficacy as a treatment for malignant disease. Further work is needed to develop cryosurgery and needle ablation in order to delineate what role these techniques will ultimately play in the management of RCC. PMID:11394447

Johnson, D B; Nakada, S Y

2001-05-01

229

Occult connective tissue diseases mimicking idiopathic interstitial pneumonias  

Microsoft Academic Search

In patients with interstitial lung disease (ILD), the diagnosis of idiopathic interstitial pneumonia is usually made after excluding, among other conditions, connective tissue diseases (CTDs). Although in most patients with a CTD and respiratory symptoms, the systemic nature of the disease is obvious, the ILD-related manifestations in CTDs may often dominate the clinical picture or precede systemic findings and thus

G. E. Tzelepis; S. P. Toya; H. M. Moutsopoulos

2008-01-01

230

Karyomegalic interstitial nephritis with focal segmental glomerulosclerosis: A rare association  

PubMed Central

Karyomegalic interstitial nephritis (KIN) is a rare form of, progressive chronic interstitial nephritis. We present a case of KIN in a child, who was also found to have nephrotic syndrome because of focal segmental glomerulosclerosis on renal biopsy. To our knowledge, this is the first case of KIN associated with glomerulopathy. PMID:24701046

Radha, S.; Tameem, A.; Rao, B. S.

2014-01-01

231

Pigment-based identification of ozone-damaged pine needles as a basis for spectral segregation of needle conditions.  

PubMed

Air pollution affects large areas of forest, and field assessment of these effects is a costly, site-specific process. This paper establishes a biochemical basis for identifying ozone-damaged pine trees to facilitate efficient remote sensing assessment of air pollution damage. Several thousand live needles were collected from ponderosa pine (Pinus ponderosa) and Jeffrey pine (P. jeffreyi) trees at three sites in Plumas National Forest and Sequoia-Kings Canyon National Park. These needles were assembled into 504 samples (based on the abaxial surface) and grouped according to five dominant needle conditions (green, winter fleck, sucking insect damage, scale insect damage, and ozone damage) and a random mixture of needles. Pigment concentrations per unit needle area of chlorophyll a, chlorophyll b, and total carotenoids were measured. The following pigment concentration ratios were calculated for all samples: chlorophyll a/total carotenoids, chlorophyll b/total carotenoids, total chlorophyll/carotenoids, chlorophyll a/chlorophyll b. The group of ozone-damaged needles had significantly lower mean pigment concentrations (family-wise p < 0.01) and significantly lower mean chlorophyll a/total carotenoid and total chlorophyll/total carotenoid ratios (family-wise p < 0.01) than all other groups of needles. Ozone-damaged needles had a significantly lower mean chlorophyll a/chlorophyll b ratio than all other groups except one (family-wise p < 0.01). Linear discriminant analysis with three factors (chlorophyll a concentration, the chlorophyll a/carotenoid ratio, and the chlorophyll a/chlorophyll b ratio) and subsequent maximum likelihood classification of damaged and non-damaged needles gave an overall cross-validated accuracy of 96%. These ozone-damaged needles are biochemically unique in relation to other needle conditions in this study, and further research is needed to generalize these results. PMID:19329674

Di Vittorio, Alan V

2009-01-01

232

MRI-Guided Vascular Access with an Active Visualization Needle  

PubMed Central

Purpose To develop an approach to vascular access under MRI, as a component of comprehensive MRI-guided cardiovascular catheterization and intervention. Materials and Methods We attempted jugular vein access in healthy pigs as a model of “difficult” vascular access. Procedures were performed under real-time MRI guidance using reduced field of view imaging. We developed an “active” MRI antenna-needle having an open-lumen, distinct tip appearance and indicators of depth and trajectory, in order to enhance MRI visibility during the procedure. We compared performance of the active needle against an unmodified commercial passively-visualized needle, measured by procedure success among operators with different levels of experience. Results MRI-guided central vein access was feasible using both the active needle and the unmodified passive needle. The active needle required less time (88 vs. 244 sec, p=0.022) and fewer needle passes (4.5 vs. 9.1, p=0.028), irrespective of operator experience. Conclusion MRI-guided access to central veins is feasible in our animal model. When image guidance is necessary for vascular access, performing this component under MRI will allow wholly MRI-guided catheterization procedures that do not require adjunctive imaging facilities such as X-ray or ultrasound. The active needle design showed enhanced visibility, as expected. These capabilities may permit more complex catheter-based cardiovascular interventional procedures enabled by enhanced image guidance. PMID:22006552

Saikus, Christina E.; Ratnayaka, Kanishka; Barbash, Israel M.; Colyer, Jessica H.; Kocaturk, Ozgur; Faranesh, Anthony Z.; Lederman, Robert J.

2011-01-01

233

Sensorless Motion Planning for Medical Needle Insertion in Deformable Tissues  

PubMed Central

Minimally invasive medical procedures such as biopsies, anesthesia drug injections, and brachytherapy cancer treatments require inserting a needle to a specific target inside soft tissues. This is difficult because needle insertion displaces and deforms the surrounding soft tissues causing the target to move during the procedure. To facilitate physician training and preoperative planning for these procedures, we develop a needle insertion motion planning system based on an interactive simulation of needle insertion in deformable tissues and numerical optimization to reduce placement error. We describe a 2-D physically based, dynamic simulation of needle insertion that uses a finite-element model of deformable soft tissues and models needle cutting and frictional forces along the needle shaft. The simulation offers guarantees on simulation stability for mesh modications and achieves interactive, real-time performance on a standard PC. Using texture mapping, the simulation provides visualization comparable to ultrasound images that the physician would see during the procedure. We use the simulation as a component of a sensorless planning algorithm that uses numerical optimization to compute needle insertion offsets that compensate for tissue deformations. We apply the method to radioactive seed implantation during permanent seed prostate brachytherapy to minimize seed placement error. PMID:19126473

Alterovitz, Ron; Goldberg, Kenneth Y.; Pouliot, Jean; Hsu, I-Chow

2009-01-01

234

CPT DESCRIPTION 10021 Fine needle aspiration; without imaging guidance  

E-print Network

11755 Biopsy of nail unit 15850-15851 Removal of sutures under anesthesia 15852 Dressing change under, needle core 19101 Biopsy of breast, open incisional 19102 Biopsy of breast, percutaneous, needle core Removal of FB in muscle or tendon sheath, simple 20694 Removal of external fixation system 20950

Jones, Michelle

235

Forest Watch Data Book Research with 2011 Needles  

E-print Network

Forest Watch Data Book 2012-2013 Research with 2011 Needles A Study of White Pine Health In New England #12;Rock, B.N., and M. Carlson. 2013. Forest Watch Data Book 2012-2013: Research with 2011 Needles. Forest Watch, University of New Hampshire, Durham, NH. Copyright©2013, University of New Hampshire

Pringle, James "Jamie"

236

Saprotrophic fungi transform organic phosphorus from spruce needle litter  

Microsoft Academic Search

Fungal decomposition of and phosphorus transformation from spruce litter needles (Picea abies) were simulated in systems containing litter needles inoculated with individual saprotrophic fungal strains and their mixtures. Fungal strains of Setulipes androsaceus (L.) Antonín, Chalara longipes (Preus) Cooke, Ceuthospora pinastri (Fr.) Höhn., Mollisia minutella (Sacc.) Rehm, Scleroconidioma sphagnicola Tsuneda, Currah & Thormann and an unknown strain NK11 were used

Ond?ej Koukol; František Novák; Richard Hrabal; Miroslav Vosátka

2006-01-01

237

Characteristics of probe electrospray generated from a solid needle.  

PubMed

Probe electrospray ionization (PESI) has recently been developed, in which the electrospray was generated from a solid needle instead of by using a capillary. In this paper, the characteristics of probe electrospray ionization were studied based on the measurement of spray current, optical microscopy, and PESI mass spectrometry. In the experiment, the solid needle was moved up and down a vertical axis, and a small amount of sample was repeatedly loaded to the needle when the tip of the needle touched the surface of the liquid sample at the lowest position. After the application of high voltage, a liquid droplet was formed on the tip of the solid needle probe, with its size was determined by the size of the needle tip. The liquid flow rate to the tip, as indicated by the spray current, depends on the voltage applied to the needle as well as the loaded liquid amount. Stable electrospray can be maintained until the total consumption of liquid sample. The kilohertz current pulsation takes place in the case of overloading the sample to the needle. The influences of the applied voltage and the liquid flow rate on the PESI mass spectra were also examined. PMID:18698704

Chen, Lee Chuin; Nishidate, Kentaro; Saito, Yuta; Mori, Kunihiko; Asakawa, Daiki; Takeda, Sen; Kubota, Takeo; Hori, Hirokazu; Hiraoka, Kenzo

2008-09-01

238

Biocompatible Polymer Needle Coating For Improved Patient Safety  

E-print Network

Biocompatible Polymer Needle Coating For Improved Patient Safety The University of Florida, increasing patient safety and offering valuable competitive and market advantage Technology Researchers a needle is used to extract cells from a lump or mass for microscopic evaluation. One safety concern

Slatton, Clint

239

Orientational ordering of hard zigzag needles in one dimension  

Microsoft Academic Search

The orientational ordering and the tilt angle behavior of a one-dimensional fluid of hard zigzag needles are examined by means of transfer matrix method and Onsager theory. The centers of mass of the particles are restricted to a line, while the orientational unit vectors are allowed to rotate freely in two dimensions. It is shown that zigzag needles do not

Péter Gurin; Szabolcs Varga

2010-01-01

240

Phase ordering of hard needles on a quasicrystalline substrate.  

PubMed

Quasicrystals possess long-range positional and orientational order. However, they cannot be periodic in space due to their non-crystallographic symmetries such as a 10-fold rotational axis. We perform Monte Carlo simulations of two-dimensional hard-needle systems subject to a quasiperiodic substrate potential. We determine phase diagrams as a function of density and potential strength for two needle lengths. With increasing potential strength short needles tend to form isolated clusters that display directional order along the decagonal directions. Long needles create interacting clusters that stabilize the nematic phase. At large potential strengths the clusters position themselves on two interwoven Fibonacci sequences perpendicular to the cluster orientation. Alternatively, one obtains extended domains of needle clusters which are aligned along all decagonal symmetry directions. PMID:22583263

Kählitz, Philipp; Stark, Holger

2012-05-01

241

Limited retention of micro-organisms using commercialized needle filters.  

PubMed

A study was undertaken to compare a commercialized needle filter with a 0.2-?m filtered epidural set and a non-filtered standard needle. No culturable bacteria were detected following filtration through the 0.2-?m filter. Bacterial breakthrough was observed with the filtered needle (pore size 5?m) and the non-filtered needle. Filtered systems (0.2?m) should be employed to achieve total bacterial retention. This highlights that filtration systems with different pore sizes will have varying ability to retain bacteria. Healthcare professionals need to know what type/capability of filter is implied on labels used by manufacturers, and to assess whether the specification has the desired functionality to prevent bacterial translocation through needles. PMID:25618235

Elbaz, W; McCarthy, G; Mawhinney, T; Goldsmith, C E; Moore, J E

2015-03-01

242

High-dose-rate interstitial brachytherapy for gynecologic malignancies—dosimetric changes during treatment period  

PubMed Central

To overcome cranio-caudal needle displacement in pelvic high-dose-rate interstitial brachytherapy (HDRIB), we have been utilizing a fullystretched elastic tape to thrust the template into the perineum. The purpose of the current study was to evaluate dosimetric changes during the treatment period using this thrusting method, and to explore reproducible planning methods based on the results of the dosimetric changes. Twenty-nine patients with gynecologic malignancies were treated with HDRIB at the Cancer Institute Hospital. Pre-treatment and post-treatment computed tomography (CT) scans were acquired and a virtual plan for post-treatment CT was produced by applying the dwell positions/times of the original plan. For the post-treatment plan, D90 for the clinical target volume (CTV) and D2cc for the rectum and bladder were assessed and compared with that for the original plan. Cranio-caudal needle displacement relative to CTV during treatment period was only 0.7 ± 1.9 mm. The mean D90 values for the CTV in the pre- and post-treatment plans were stable (6.8 Gy vs. 6.8 Gy) and the post-treatment/pre-treatment D90 ratio was 1.00 ± 0.08. The post-/pre-treatment D2cc ratio was 1.14 ± 0.22 and the mean D2cc for the rectum increased for the post-treatment plan (5.4 Gy vs. 6.1 Gy), especially when parametrial infiltration was present. The mean D2cc for the bladder was stable (6.3 Gy vs. 6.6 Gy) and the ratio was 1.06 ± 0.20. Our thrusting method achieved a stable D90 for the CTV, in contrast to previous prostate HDRIB reports displaying reductions of 35–40% for D90 during the treatment period. PMID:23297319

Onoe, Tsuyoshi; Nose, Takayuki; Yamashita, Hideomi; Yoshioka, Minoru; Toshiyasu, Takashi; Kozuka, Takuyo; Oguchi, Masahiko; Nakagawa, Keiichi

2013-01-01

243

Interstitial lung diseases in Saudi Arabia: A single-center study  

PubMed Central

BACKGROUND: There are relatively few epidemiological studies on interstitial lung disease (ILD) worldwide. OBJECTIVE: To report the incident cases of ILD and compare our data with reports from other populations. METHODS: Newly diagnosed ILDs were prospectively collected at a single tertiary care hospital from January 2008 to December 2011. Detailed demographic and clinical data were collected at the time of diagnosis, along with the results from diagnostic procedures, including high-resolution computed tomography (HRCT), serological tests, bronchoalveolar lavage (BAL), transbronchial lung biopsy, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and surgical lung biopsy. RESULTS: A total of 330 cases were included. The mean age was 55.4 ± 14.9 years. There was a slight predominance of females (202; 61.2%), and the male-to-female ratio was 1:1.37. The most frequent disease was connective tissue disease (CTD)-associated ILD (34.8%), followed by idiopathic pulmonary fibrosis (IPF) (23.3%), sarcoidosis (20%), and hypersensitivity pneumonitis (6.3%). Non-classifiable ILD was present in 1.8% of the total ILD cases. HRCT was performed in 97.3% of the cases, BAL in 17.5%, transbronchial lung biopsy in 21.8%, EBUS-TBNA in 4.5%, and surgical lung biopsy in 22.7% (38.6% of which were performed among the idiopathic interstitial pneumonia cases). CONCLUSIONS: CTD-ILD and IPF were the most frequently observed ILDs in this Saudi Arabian population. Similarities and differences were found with respect to the previous reports from other countries. PMID:23440334

Alhamad, Esam H.

2013-01-01

244

Projector-Based Augmented Reality for Intuitive Intraoperative Guidance in Image-Guided 3D Interstitial Brachytherapy  

SciTech Connect

Purpose: The aim of this study is to implement augmented reality in real-time image-guided interstitial brachytherapy to allow an intuitive real-time intraoperative orientation. Methods and Materials: The developed system consists of a common video projector, two high-resolution charge coupled device cameras, and an off-the-shelf notebook. The projector was used as a scanning device by projecting coded-light patterns to register the patient and superimpose the operating field with planning data and additional information in arbitrary colors. Subsequent movements of the nonfixed patient were detected by means of stereoscopically tracking passive markers attached to the patient. Results: In a first clinical study, we evaluated the whole process chain from image acquisition to data projection and determined overall accuracy with 10 patients undergoing implantation. The described method enabled the surgeon to visualize planning data on top of any preoperatively segmented and triangulated surface (skin) with direct line of sight during the operation. Furthermore, the tracking system allowed dynamic adjustment of the data to the patient's current position and therefore eliminated the need for rigid fixation. Because of soft-part displacement, we obtained an average deviation of 1.1 mm by moving the patient, whereas changing the projector's position resulted in an average deviation of 0.9 mm. Mean deviation of all needles of an implant was 1.4 mm (range, 0.3-2.7 mm). Conclusions: The developed low-cost augmented-reality system proved to be accurate and feasible in interstitial brachytherapy. The system meets clinical demands and enables intuitive real-time intraoperative orientation and monitoring of needle implantation.

Krempien, Robert [Department of Radiation Oncology, University of Heidelberg, Heidelberg (Germany)], E-mail: robert_krempien@med.uni-heidelberg-de; Hoppe, Harald; Kahrs, Lueder; Daeuber, Sascha; Schorr, Oliver [Institute for Process Control and Robotics, Department of Computer Science, University of Karlsruhe, Karlsruhe (Germany); Eggers, Georg [Department of Cranio-Maxillo-Facial Surgery, University of Heidelberg, Heidelberg (Germany); Bischof, Marc; Munter, Marc W.; Debus, Juergen; Harms, Wolfgang [Department of Radiation Oncology, University of Heidelberg, Heidelberg (Germany)

2008-03-01

245

The effect of thermal redistribution of various interstitial impurities on equilibrium vacancy concentration in BCC substitutional-interstitial alloys  

Microsoft Academic Search

The equilibrium vacancy concentration in bcc substitutional-interstitial alloys is calculated taking into account thermal\\u000a redistribution of the interstitial component in different types of interstices. The conditions where this effect gives rise\\u000a to a decrease or increase in vacancy concentration are formulated.

V. A. Volkov; S. I. Masharov

2007-01-01

246

Experimental study of needle-tissue interaction forces: effect of needle geometries, insertion methods and tissue characteristics.  

PubMed

A thorough understanding of needle-tissue interaction mechanics is necessary to optimize needle design, achieve robotically needle steering, and establish surgical simulation system. It is obvious that the interaction is influenced by numerous variable parameters, which are divided into three categories: needle geometries, insertion methods, and tissue characteristics. A series of experiments are performed to explore the effect of influence factors (material samples n=5 for each factor) on the insertion force. Data were collected from different biological tissues and a special tissue-equivalent phantom with similar mechanical properties, using a 1-DOF mechanical testing system instrumented with a 6-DOF force/torque (F/T) sensor. The experimental results indicate that three basic phases (deformation, insertion, and extraction phase) are existent during needle penetration. Needle diameter (0.7-3.2mm), needle tip (blunt, diamond, conical, and beveled) and bevel angle (10-85°) are turned out to have a great influence on insertion force, so do the insertion velocity (0.5-10mm/s), drive mode (robot-assisted and hand-held), and the insertion process (interrupted and continuous). Different tissues such as skin, muscle, fat, liver capsule and vessel are proved to generate various force cures, which can contribute to the judgement of the needle position and provide efficient insertion strategy. PMID:25169657

Jiang, Shan; Li, Pan; Yu, Yan; Liu, Jun; Yang, Zhiyong

2014-10-17

247

Percutaneous CT-Guided Core Needle Biopsy Versus Fine Needle Aspiration in Diagnosing Pneumonia and Mimics of Pneumonia  

Microsoft Academic Search

The purpose of this study was to determine the diagnostic value of percutaneous core needle biopsy (CNB) relative to fine needle aspiration (FNA) in patients with pneumonia and pneumonia mimics. In this prospective study we present our experience with 48 thoracic FNAs and CNBs carried out on 48 patients with pneumonia and pneumonia mimics. Samples were obtained from all patients

Loukas Thanos; Panagiota Galani; Sophia Mylona; Maria Pomoni; Nikolaos Mpatakis

2004-01-01

248

[Interstitial cystitis. An important differential diagnosis].  

PubMed

Interstitial cystitis (IC) is a chronic, debilitating inflammatory disease of the urinary bladder, characterized by chronic pelvic pain, urgency/frequency symptoms, and decrease of the functional bladder capacity. Both the etiology and pathogenesis of the condition that predominantly affects women are still not fully understood. Thus, a causal therapeutic approach still does not exist. IC remains a strict diagnosis of exclusion; distinct histopathological findings within the bladder wall are frequently found, although they are not pathognomonic. The diagnostic criteria elaborated by the NIH are helpful in clinical research; their dogmatic utilization will however lead to an underdiagnosis of IC in 60% of the patients. IC-specific symptom questionnaires and validated symptom scales help the physician to assess the therapeutic response during the follow-up of the patients. PMID:16534650

van Ophoven, A; Oberpenning, F

2006-04-01

249

From interstitial cystitis to chronic pelvic pain  

PubMed Central

There are still many things to be found out about interstitial cystitis/painful bladder syndrome (IC/PBS) because the pathological processes underlying the condition are not yet elucidated, biological markers of the condition are not yet available, and the type and severity of symptoms can vary, so, clearly defining the condition is not yet possible. For example, it is not clearly understood whether IC/PBS represents a systemic disease, if it is localized in the bladder, or if it was initially localized in the bladder and it later evolved into a systemic disease. This condition is best managed by using a multidisciplinary approach. Management requires a good integration and knowledge of all pelvic organ systems and other systems including musculoskeletal, neurologic, and psychiatric systems. PMID:20968203

Cauni, V; Gutue, S; Blaj, I; Jinga, V; Geavlete, P

2010-01-01

250

From interstitial cystitis to chronic pelvic pain.  

PubMed

There are still many things to be found out about interstitial cystitis/painful bladder syndrome (IC/PBS) because the pathological processes underlying the condition are not yet elucidated, biological markers of the condition are not yet available, and the type and severity of symptoms can vary, so, clearly defining the condition is not yet possible. For example, it is not clearly understood whether IC/PBS represents a systemic disease, if it is localized in the bladder, or if it was initially localized in the bladder and it later evolved into a systemic disease. This condition is best managed by using a multidisciplinary approach. Management requires a good integration and knowledge of all pelvic organ systems and other systems including musculoskeletal, neurologic, and psychiatric systems. PMID:20968203

Persu, C; Cauni, V; Gutue, S; Blaj, Irina; Jinga, V; Geavlete, P

2010-01-01

251

Low dose cabergoline induced interstitial pneumonitis.  

PubMed

Certain dopaminergic anti-Parkinson drugs (ergolines) have repeatedly been identified as a cause of pleuropulmonary disease with a focus on serosal cell damage. Recently, a pathogenetic link between ergolines and prior asbestos exposure was suggested, as regards the development of pleural pathology. This report describes a patient with idiopathic Parkinson's disease, who was on a multiple drug regimen including low dose cabergoline. The patient developed a febrile illness with widespread bilateral lung infiltrations nonresponsive to beta-lactam and macrolide antibiotics. Bronchoalveolar lavage and transbronchial lung biopsy showed a "hypersensitivity-like" interstitial lung disease, which cleared almost completely within 2 months after simple drug withdrawal. Circumstantial evidence suggests a so far undescribed adverse lung reaction to cabergoline, devoid of the more usual pleural changes. PMID:10573251

Frank, W; Moritz, R; Becke, B; Pauli, R

1999-10-01

252

[Lung cancer combined with idiopathic interstitial pneumonias].  

PubMed

It is known that patients with idiopathic interstitial pneumonias (IIPs) have an increased incidence of lung cancer. The purpose of this study was to evaluate the outcome of surgical treatment and to establish the surgical strategy for lung cancer with IIPs. Twenty-five patients with lung cancer and IIPs who were admitted in our hospital from 1996 to 2004 were examined. Eight patients underwent lobectomy with mediastinal lymph node dissection, while 17 patients underwent limited resection. The actuarial 3-year survival rate was 43%. There were no postoperative acute exacerbation of IIPs. We considered most patients were in a stable state of IIPs preoperatively, and we made effort to treat IIPs with limited resection. The prognosis of IIPs was poor. It is difficult to decide whether to carry out limited resection. PMID:15678958

Imakiire, Takayuki; Koike, T; Watanabe, T; Saito, Y; Hirono, T

2005-01-01

253

[Drug-induced interstitial lung diseases].  

PubMed

Drug-induced infiltrative lung disease may manifest as variable clinical radiological patterns, including subacute or chronic interstitial pneumonia, pulmonary fibrosis, eosinophilic pneumonia, organising pneumonia, pulmonary edema, or sarcoidosis. A large amount of drugs have been incriminated, including those used in cardiovascular diseases (amiodarone, statins and angiotensin converting enzyme inhibitors), antibiotics (minocycline, nitrofurantoin), most of anticancer drugs (and especially chemotherapy and chest radiation), treatment of rheumatoid arthritis, as well as more recent drugs. A high index of suspicion is therefore required in any patient with infiltrative lung disease and the web-based tool www.pneumotox.com will help to list possible causative drugs. The following steps are necessary: history and timing of drug exposure, clinical and imaging pattern, exclusion of other causes of infiltrative lung disease, improvement following drug discontinuation. Rechallenge, dangerous, is not recommended. PMID:25362778

Bonniaud, Philippe; Georges, Marjolaine; Favrolt, Nicolas; Camus, Philippe

2014-09-01

254

Smoking-Related "Interstitial" Lung Disease.  

PubMed

Context .- Emphysema, respiratory bronchiolitis, desquamative interstitial pneumonia, pulmonary Langerhans' cell histiocytosis, small-airway injury including submucosal and adventitial fibrosis, increased bronchus-associated lymphoid tissue, and small artery/arteriolar wall thickening are recognized histologic findings in cigarette smokers. It has only recently been acknowledged that the range of lung injury from cigarette smoke is wider than generally accepted, in particular, there is increasing recognition that fibrosis of alveolar walls occurs in smokers. Objectives .- To review the literature that describes the range of histologic findings in cigarette smokers and that links cigarette smoke exposure to the development of alveolar wall fibrosis. Data Sources .- Relevant peer-reviewed literature indexed in PubMed (National Library of Medicine) form the basis of this review. Conclusions .- Smokers demonstrate a wide range of lung injury at biopsy that defies simple placement within single categories, and the current categories do not adequately take into account the importance of alveolar wall and airway fibrosis. PMID:25415179

Franks, Teri J; Galvin, Jeffrey R

2014-11-21

255

Interstitial and substitutional solute effects in intermetallics  

SciTech Connect

This volume addresses recent developments in the understanding of the effects of interstitial and substitutional solute atoms on the physical and mechanical properties of intermetallic compounds. Topics discussed include the theory, modeling, and experimental verification of such effects as static and dynamic strain aging, the Portevin-le Chatelier effect, solid solution hardening behavior, dislocation-solute interactions, and related topics such as the amelioration of environmental embrittlement by various solutes. Topics covered include: (1) Vacancy-solute interactions in FeAl-based alloys; (2) Static and dynamic strain aging in microalloyed NiAl-based alloys; (3) Design fundamentals for Gamma TiAl alloys; and (4) Strain rate sensitivity of Cr-stabilized cubic titanium trialuminides.

Baker, I.; Noebe, R.D.; George, E.P. (eds.)

1998-01-01

256

Ultrasound applicators for interstitial thermal coagulation.  

PubMed

Direct-coupled (DC) and catheter-cooled (CC) ultrasound applicator configurations were evaluated for high-temperature ultrasound interstitial thermal therapy (USITT) using computer simulations, acoustic beam measurements, and in vivo temperature measurements. The DC devices consist of 2.2-mm diameter tubular ultrasound transducers encapsulated within a thin biocompatible plastic coating, which can be inserted directly into the tissue. The CC devices incorporate 1.5-mm diameter tubular transducers, which are inserted within 2.2to 2.4-mm diameter plastic implant catheters and require an integrated water-cooling scheme. Simulated transient temperature profiles and cumulative thermal dose distributions indicate that each of these applicator configurations can produce target temperatures greater than 50 degrees C and corresponding thermal doses greater than 300 to 600 equivalent minutes at 43 degrees C (EM(43 degrees C)) within 5 min at a radial depth of 1 to 1.5 cm in moderately perfused tissues. Theoretical investigations of air-cooling implemented within DC applicators demonstrated a significant enhancement of thermal penetration compared with non-cooled DC applicators, thus approaching performance attainable with CC devices. Temperature distributions achieved with DC and CC applicators in vivo were in agreement with theoretical calculations and further demonstrate that the devices are practical, sufficient power output levels can be obtained, and the angular heating profiles can be shaped or directed to protect non-targeted critical normal tissues. This preliminary study demonstrates that these interstitial ultrasound applicators have potential to provide controlled thermal coagulation and necrosis of small target regions and deserve further investigation and development for possible implementation in the treatment of benign and cancerous lesions in sites such as prostate, liver, and brain. PMID:18244315

Diederich, C J; Nau, W H; Stauffer, P R

1999-01-01

257

The multiple faces of leukocyte interstitial migration  

PubMed Central

Spatiotemporal control of leukocyte dynamics within tissues is critical for successful innate and adaptive immune responses. Homeostatic trafficking and coordinated infiltration into and within sites of inflammation and infection rely on signaling in response to extracellular cues that in turn controls a variety of intracellular protein networks regulating leukocyte motility, migration, chemotaxis, positioning, and cell–cell interaction. In contrast to mesenchymal cells, leukocytes migrate in an amoeboid fashion by rapid cycles of actin polymerization and actomyosin contraction, and their migration in tissues is generally referred to as low adhesive and nonproteolytic. The interplay of actin network expansion, contraction, and adhesion shapes the exact mode of amoeboid migration, and in this review, we explore how leukocyte subsets potentially harness the same basic biomechanical mechanisms in a cell-type-specific manner. Most of our detailed understanding of these processes derives from in vitro migration studies in three-dimensional gels and confined spaces that mimic geometrical aspects of physiological tissues. We summarize these in vitro results and then critically compare them to data from intravital imaging of leukocyte interstitial migration in mouse tissues. We outline the technical challenges of obtaining conclusive mechanistic results from intravital studies, discuss leukocyte migration strategies in vivo, and present examples of mode switching during physiological interstitial migration. These findings are also placed in the context of leukocyte migration defects in primary immunodeficiencies. This overview of both in vitro and in vivo studies highlights recent progress in understanding the molecular and biophysical mechanisms that shape robust leukocyte migration responses in physiologically complex and heterogeneous environments. PMID:24573488

Lämmermann, Tim; Germain, Ronald N.

2014-01-01

258

Interstitial-interstitial interaction of oxygen atoms in a Nb-based ternary body-centered-cubic system  

NASA Astrophysics Data System (ADS)

An extended statistical mechanical treatment is suggested to calculate the interstitial-interstitial interaction in a ternary bcc system. With the assumption of the first-order quasichemical approximation and the conservative condition of the interstitial solutes concentration, the numerical solution of the interstitial interaction can be determined by Fermi-Dirac statistics. The calculated results for a Nb-M (V or Ti)-O system shown that the O-O interaction in Nb-based alloys exhibits a repulsive effect, and is markedly influenced by the substitutional solute concentration. These results can be applied as useful information for the description and understanding of the interstitials atoms' behaviors in ternary alloy systems.

Yu, Liming; Yin, Fuxing; Ping, Dehai; Liu, Yongchang

2011-06-01

259

Ozone production of hollow-needle-to-mesh negative corona discharge enhanced by dielectric tube on the needle electrode  

NASA Astrophysics Data System (ADS)

For the hollow-needle-to-mesh negative corona discharge in air, we studied the effect of placing the dielectric tube on the needle electrode and the effect of various positions of the end of this tube with respect to the tip of the needle electrode on the concentration of ozone produced by the discharge, the ozone production yield and the discharge V-A characteristics. We found that the placement of the dielectric tube on the needle electrode with a suitable position of this tube end with respect to the tip of the needle electrode for a particular discharge power led to a more than fourfold increase in the concentration of ozone produced by the discharge and also, for a constant airflow, the ozone production yield.

Pekárek, Stanislav

2014-12-01

260

Transport and Transformation of Dissolved Organic Matter in Soil Interstitial Water Across Forested, Montane Hillslopes  

NASA Astrophysics Data System (ADS)

Dissolved organic matter (DOM) is a ubiquitous mixture of compounds formed from the degradation of both terrestrial and microbial material. The abundance and composition of the DOM present in stream water is important to stream processes such as UV light attenuation, nutrient supply and metal sorption. However, an excess of DOM can cause reactions with chlorination compounds at drinking water treatment plants, creating potentially harmful disinfection byproducts. Currently, little is known regarding the influence of soil interstitial water on stream DOM composition. In this study, we explore the role of interstitial water on DOM transport and transformation from the hillslope to the stream in a montane catchment within the Boulder Creek Critical Zone Observatory in Colorado. We installed a suite of tension lysimeters located within the rooting zone across representative north- and south-facing slopes. Interstitial water and stream samples were collected daily for approximately seven weeks during the 2013 spring snow melt period and analyzed for DOM composition using fluorescence spectroscopy. To date, we have used fluorescence index (FI) to evaluate differences between microbial and terrestrial DOM inputs and humification index (HIX) to assess degree of humification undergone by the DOM. Preliminary results indicate that FI was significantly correlated with hillslope aspect (p<.01), with higher FI on north-facing slopes, suggesting more microbial precursor material. Stream samples reveal greater humification throughout the snowmelt period (p<.01). This increase could suggest a transition from deeper groundwater sources to shallow soil interstitial water inputs into the stream during snowmelt. These preliminary results suggest that changes in DOM composition through the catchment during snowmelt can be linked to hydrologic transport. Further site specific model development will reveal explicit changes in the DOM chemistry and will increase our understanding of fundamental nutrient cycling processes at the hillslope to catchment scale.

Burns, M. A.; McKnight, D. M.; Gabor, R. S.; Brooks, P. D.; Barnard, H. R.

2013-12-01

261

Swallowed a needle stuck in heart.  

PubMed

Cardiac tamponade (CT) is a clinical entity characterized by hemodynamic insufficiency resulting from increased intrapericardial pressure due to accumulation of contents such as serous fluid, blood, and pus. CT is a treatable cause of cardiogenic shock, which can be fatal unless diagnosed promptly. Dyspnea, chest pain, hypotension, tachycardia, pulsus paradoxus, raised jugular venous pressure, muffled heart sounds, decreased electrocardiographic voltage, and enlarged cardiac silhouette on chest X-ray are the major clinical signs in CT. Idiopathic or viral pericardititis, iatrogenic trauma during percutaneous coronary interventions or coronary artery bypass grafting, external trauma, malignancies, acute or chronic kidney disease, collagen vascular diseases, tuberculosis, radiation on the chest wall, hypothyroidism and aortic dissection are the etiologic factors. Herein, we present a case of surgically treated CT, which was diagnosed in the third day of ingestion of a sewing needle. PMID:25135029

Yolcu, Mustafa; Ayd?n, Ahmet; Korkmaz, Ali Fuat; Da?, Özgür; Ipek, Emrah; Erkut, Bilgehan

2014-07-01

262

Needle steering for robot-assisted insertion into soft tissue: A survey  

NASA Astrophysics Data System (ADS)

Needle insertion is a common surgical procedure used in diagnosis and treatment. The needle steering technologies make continuous developments in theoretical and practical aspects along with the in-depth research on needle insertion. It is necessary to summarize and analyze the existing results to promote the future development of theories and applications of needle insertion. Thus, a survey of the state of the art of research is presented on algorithms of needle steering techniques, the surgical robots and devices. Based on the analysis of the needle insertion procedure, the concept of needle steering is defined as a kinematics problem, which is to place the needle at the target and avoid the obstacles. The needle steering techniques, including the artificial potential field method and the nonholonomic model, are introduced to control the needles for improving the accuracy. Based on the quasi-static thinking, the virtual spring model and the cantilever-beam model are developed to calculate the amount of needle deflection and generate the needle path. The phantoms instead of the real tissue are used to verify the models mentioned in most of the experimentations. For the desired needle trajectories, the image-guided robotic devices and some novel needles are presented to achieve the needle steering. Finally, the challenges are provided involving the controllability of the long flexible needle and the properties of soft tissue. The results and investigations can be used for further study on the precision and accuracy of needle insertion.

Gao, Dedong; Lei, Yong; Zheng, Haojun

2012-07-01

263

Self-powered microneedle-based biosensors for pain-free high-accuracy measurement of glycaemia in interstitial fluid.  

PubMed

In this work a novel self-powered microneedle-based transdermal biosensor for pain-free high-accuracy real-time measurement of glycaemia in interstitial fluid (ISF) is reported. The proposed transdermal biosensor makes use of an array of silicon-dioxide hollow microneedles that are about one order of magnitude both smaller (borehole down to 4µm) and more densely-packed (up to 1×10(6)needles/cm(2)) than state-of-the-art microneedles used for biosensing so far. This allows self-powered (i.e. pump-free) uptake of ISF to be carried out with high efficacy and reliability in a few seconds (uptake rate up to 1µl/s) by exploiting capillarity in the microneedles. By coupling the microneedles operating under capillary-action with an enzymatic glucose biosensor integrated on the back-side of the needle-chip, glucose measurements are performed with high accuracy (±20% of the actual glucose level for 96% of measures) and reproducibility (coefficient of variation 8.56%) in real-time (30s) over the range 0-630mg/dl, thus significantly improving microneedle-based biosensor performance with respect to the state-of-the-art. PMID:25601169

Strambini, L M; Longo, A; Scarano, S; Prescimone, T; Palchetti, I; Minunni, M; Giannessi, D; Barillaro, G

2015-04-15

264

Metallic ferromagnetism in the Kondo lattice  

Microsoft Academic Search

Metallic magnetism is both ancient and modern, occurring in such familiar settings as the lodestone in compass needles and the hard drive in computers. Surprisingly, a rigorous theoretical basis for metallic ferromagnetism is still largely missing. The Stoner approach perturbatively treates Coulomb interactions when the latter need to be large, while the Nagaoka approach incorporates thermodynamically negligible electrons into a

S. J. Yamamoto; Qimiao Si

2010-01-01

265

Desquamative interstitial pneumonitis in a patient with systemic lupus erythematosus.  

PubMed

Desquamative interstitial pneumonia (DIP) is a rare form of interstitial lung disease (ILD) commonly found among healthy smokers. ILD is a rare manifestation of systemic lupus erythematosus (SLE), and typically associated with a histopathological pattern of nonspecific interstitial pneumonia (NSIP). The present article describes an unusual case of DIP in a nonsmoking patient with SLE presenting as NSIP. DIP can occur in the context of SLE in patients with a negative smoking history, and clinicians should consider lung biopsy to correctly classify ILD with unusual presentation on computed tomography scan. PMID:22332137

Esmaeilbeigi, Faranak; Juvet, Stephen; Hwang, David; Mittoo, Shikha

2012-01-01

266

[Suicide attempt by an interstitial cystitis patient : a case report].  

PubMed

We report a suicide attempt by an interstitial cystitis patient. A 68-year-old woman consulted several clinics with complaints of urinary frequency and bladder pain, but her symptoms did not improve. She was admitted to our hospital and diagnosed with interstitial cystitis. Hydrodistention was performed, and the urethral catheter removed one day after surgery. The next day, the patient was afraid that her symptoms had not improved and, due to this physical and mental distress, cut her wrist with a razor. Vascular anastomosis and neuroanastomosis were performed accordingly. Eighteen months after hydrodistention, the patient's symptoms of interstitial cystitis have much improved. PMID:25511944

Suzuki, Takahisa; Otsuka, Atsushi; Kato, Taiki; Furuse, Hiroshi; Ozono, Seiichiro

2014-11-01

267

High-performance liquid chromatographic determination of myocardial interstitial dihydroxyphenylglycol.  

PubMed

This study describes a high-performance liquid chromatographic method with electrochemical detection (HPLC-ED) for monitoring dihydroxyphenylglycol (DHPG) in the myocardial interstitial space. Using a cardiac dialysis technique, 10-microl dialysates were sampled from the myocardial interstitial space (1-min fractions) and were injected directly into the HPLC-ED system. The in vitro quantification limit for DHPG was 250 fg in a 10-microl injection. The basal DHPG concentration of dialysate was 181+/-46 pg/ml. This system offers a new possibility for monitoring myocardial interstitial DHPG levels. PMID:9200538

Takauchi, Y; Kitagawa, H; Kawada, T; Akiyama, T; Yamazaki, T

1997-05-23

268

Diagenesis of conifer needles in a coastal marine environment  

NASA Astrophysics Data System (ADS)

Physically intact fir, hemlock and cedar needles were isolated from different horizons of a sediment core from a coastal marine bay (Dabob Bay, Washington State, U.S.A.) and from nearby trees and forest litter. Green fir, hemlock and cedar needles were all characterized by glucose-rich aldose mixtures (~30% of tissue carbon), the production of vanillyl and cinnamyl CuO-derived phenols (~8% of tissue carbon) and the presence of both pinitol and myo-inositol (1-2% of tissue carbon). Needles from forest litter were enriched in lignin phenols and non-glucose aldoses and depleted in glucose and cyclitols. The sediment core contained an average of 10 mg/1 of physically intact fir, hemlock and cedar needles, which occurred in similar relative abundances and accounted for less than 1% of the total nonwoody gymnosperm tissue. Compared to the green and litter counterparts, all sedimentary needles were greatly depleted in cyclitols, glucose and p-coumaric acid and enriched in vanillyl phenol precursors. The degree of elevation of vanillyl phenol yield from the degraded needles was used to estimate minimal carbon losses from the samples, which ranged from near 40% for needle litter to almost 70% for the deepest (~100 years old) sedimentary fir/hemlock samples. Although downcore increases in carbon loss and refractory organic components indicated in situ diagenesis, the bulk of overall degradation occurred either on land or during the first 10-20 years after deposition. Atomic C/N ratios of degraded needles were lower than for green counterparts, but nitrogen was lost overall. These relative changes indicate the following stability series: vanillyl phenols > N > ferulic acid, p-hydroxy phenols, most aldoses and bulk tissue > glucose and p-coumaric acid > cyclitols (near 100% loss). Vanillic acid to vanillin ratios, (Ad/Al)v, of the green fir and hemlock needles were unusually high (0.36-0.38) and decreased downcore. Diagenesis also decreased the cinnamyl/vanillyl phenol ratio (C/V) of the deepest sedimentary fir/hemlock needles to 20% of the original value and almost tripled the carbon-normalized yield of total vanillyl plus cinnamyl phenols (?). The net result of these compositional variations was to make the lignin component of the buried conifer needles resemble lignin in gymnosperm wood, thereby leading to underestimates of needle input and mass.

Hedges, John I.; Weliky, K.

1989-10-01

269

Robotic Image-Guided Needle Interventions of the Prostate  

PubMed Central

Prostate biopsy and needle-directed prostate therapies are currently performed free-handed or with needle external templates under ultrasound guidance. Direct image-guided intervention robots are modern instruments that have the potential to substantially enhance these procedures. These may increase the accuracy and repeatability with which needles are placed in the gland. The authors’ group has developed a robot for precise prostate targeting that operates remotely alongside the patient in the magnetic resonance imaging scanner, as guided according to the image. PMID:19390670

Mozer, Pierre C; Partin, Alan W; Stoianovici, Dan

2009-01-01

270

Design and fabrication of tri-axial capillary needles in flow focusing for microencapsulation of multiple drugs and imaging agents  

NASA Astrophysics Data System (ADS)

Microencapsulation of multiple drugs and imaging agents is significant for various biomedical applications. In this work we describe a novel method based on flow focusing geometry using tri-axial metallic capillary needles manufactured by a laser beam welding process. The tri-axial needle can be readily cleaned, assembled, and aligned. With this needle assembly, we develop a tri-axial capillary flow focusing device in which different combinations of liquids are focused in the core of a high-speed gas stream coflowing through a small orifice. Under appropriate working conditions, stable cone-jet configurations with three layers of liquids in an external gas stream can be obtained, resulting in multilayered microparticles with outer shell, middle layer, and inner core. The new design of tri-axial needles enables reliable encapsulation of multiple drugs and imaging agents in biodegradable microcapsules with the enhanced size distribution, increased productivity, and improved drug-loading efficiency. Furthermore, in this method the outer and the middle shell fluids can be released to produce monodisperse microparticles at smaller scales which have potential applications in multi-modal imaging, drug delivery, material processing and biomedicine.

Si, Ting; Feng, Hanxin; Xie, Bin; Xu, Ronald

2014-03-01

271

Technique and pitfalls of ultrasound-guided core-needle biopsy of the breast  

Microsoft Academic Search

When using ultrasound guidance to perform core-needle biopsy, the curvature of the breast can be used to advantage. By entering the breast from the periphery, chest wall injury is avoided and needle visualization is improved. Visualization of the needle is expedited by bringing the needle to the lesion by using a gentle sweeping motion while keeping the transducer relatively fixed

Jennifer A Harvey; Ruth E Moran; Gia A DeAngelis

2000-01-01

272

Heating of industrial sewing machine needles: FEA model and verification using IR radiometry  

Microsoft Academic Search

With the use of synthetic fabrics and threads in high speed sewing, needle heating due to friction between the needle and the fabric becomes a serious problem which limits further increase of the sewing speed. The high temperature in the needle can accelerate thread wear, cause wear at the needle eye, and damage the thread. It can also scorch the

Qinwen Li; Evangelos Liasi; Daniel L. Simon; Ruxu Du; Jasmina Bujas-Dimitrijevic; Anshi Chen

1999-01-01

273

Broken dental needle retrieval using a surgical navigation system: a case report and literature review.  

PubMed

This paper reports a case of fractured needle retrieval in the pterygomandibular space using the Medtronic surgical navigation system. Current literature on needle fracture and retrieval in the oral cavity was also reviewed. A literature search was conducted in the following databases: PubMed, MDConsult, The Cochrane Library, and Google. A variety of keywords were used, including "needle fracture," "broken dental needle," "needle injuries in dentistry," "foreign body retrieval," and "dental needle retrieval." Articles published after 1980 were reviewed. Seventeen articles that involved broken dental needle retrieval were selected. PMID:25442246

Lee, Tim Yen Ting; Zaid, Waleed Suliman

2015-02-01

274

Complexes of self-interstitials with oxygen atoms in Ge  

SciTech Connect

Interactions of germanium self-interstitials with interstitial oxygen atoms in Ge subjected to irradiation at ?80 K and subsequently to annealing have been studied. To distinguish the processes involving vacancies and self-interstitials the doping with tin was used. It was shown that absorption lines with maximum at 602, 674, 713 and 803 cm{sup ?1} are self-interstitials-related. Two lines at 602 and 674, which develop upon annealing in the temperature range 180–240 K, belong to IO complexes, while the bands at 713 and 803 cm{sup ?1}, which emerge after annealing at T>220 K, are associated with I{sub 2}O. It is argued that the annealing of IO occurs by two mechanisms: by dissociation and by diffusion.

Khirunenko, L. I.; Pomozov, Yu. V.; Sosnin, M. G. [Institute of Physics, National Academy of Sciences of Ukraine, Prospekt Nauki 46, 03028 Kiev (Ukraine); Abrosimov, N. V.; Riemann, H. [Leibniz Institute for crystal Growth, Max-Born Str. 2, D-12489 Berlin (Germany)

2014-02-21

275

View of first level from north showing interstitial structural columns ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View of first level from north showing interstitial structural columns for the Shuttle assemble configuration. - Marshall Space Flight Center, Saturn V Dynamic Test Facility, East Test Area, Huntsville, Madison County, AL

276

48. AUTOMATIC WATER CONTROL MOTOR DRIVE FOR NEEDLES CONSTRUCTION DETAILS, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

48. AUTOMATIC WATER CONTROL MOTOR DRIVE FOR NEEDLES CONSTRUCTION DETAILS, SANTA ANA RIVER NO. 2, JAN. 24, 1977. SCE drawing no. 455667-0. - Santa Ana River Hydroelectric System, SAR-2 Powerhouse, Redlands, San Bernardino County, CA

277

Risk of Infection From Needle Reuse at a Phlebotomy Center  

Microsoft Academic Search

Objectives. This study determined infection risk for HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) from needle reuse at a phlebotomy cen- ter that possibly exposed 3810 patients to infection.

Anderson RT; Sorlie P; Backlund E; Johnson N; Rogers RG

278

Design of an endoscopic biopsy needle with flexural members  

E-print Network

As a minimally invasive means of extracting a tissue sample from a patient, current endoscopic biopsy needles generally do not preserve tissue histology and often require multiple attempts to obtain a tissue sample. This ...

Figueredo, Stacy L. (Stacy Lee), 1981-

2006-01-01

279

24. DETAIL VIEW OF NEEDLE BEAM. NOTE THE WIRE ROPE ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. DETAIL VIEW OF NEEDLE BEAM. NOTE THE WIRE ROPE TIED AROUND THE HANGER CABLE AND THE RAILING POST. March 1987 - Verde River Sheep Bridge, Spanning Verde River (Tonto National Forest), Cave Creek, Maricopa County, AZ

280

Modeling and Control of A Flexible Needle in Soft Tissue.  

E-print Network

??In this thesis, methods for improving needle steering during prostate brachytherapy are studied. Brachytherapy is a minimally-invasive, out-patient therapy for prostate cancer treatment with a… (more)

Boroomand, Arefeh

2013-01-01

281

Pressure valve for needle gate valve control. June 13, 1913. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Pressure valve for needle gate valve control. June 13, 1913. Photocopy of original drawing. Drawing on file at the Salt River Project Archives. Phoenix, Arizona - Cross Cut Hydro Plant, North Side of Salt River, Tempe, Maricopa County, AZ

282

21 CFR 878.5350 - Needle-type epilator.  

Code of Federal Regulations, 2011 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5350 Needle-type epilator. (a) Identification. A...

2011-04-01

283

21 CFR 878.5350 - Needle-type epilator.  

Code of Federal Regulations, 2010 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5350 Needle-type epilator. (a) Identification. A...

2010-04-01

284

21 CFR 878.5350 - Needle-type epilator.  

Code of Federal Regulations, 2012 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5350 Needle-type epilator. (a) Identification. A...

2012-04-01

285

21 CFR 878.5350 - Needle-type epilator.  

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5350 Needle-type epilator. (a) Identification. A...

2014-04-01

286

21 CFR 878.5350 - Needle-type epilator.  

Code of Federal Regulations, 2013 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5350 Needle-type epilator. (a) Identification. A...

2013-04-01

287

Photoacoustic image-guided needle biopsy of sentinel lymph nodes  

NASA Astrophysics Data System (ADS)

We have implemented a hand-held photoacoustic and ultrasound probe for image-guided needle biopsy using a modified clinical ultrasound array system. Pulsed laser light was delivered via bifurcated optical fiber bundles integrated with the hand-held ultrasound probe. We photoacoustically guided needle insertion into rat sentinel lymph nodes (SLNs) following accumulation of indocyanine green (ICG). Strong photoacoustic image contrast of the needle was achieved. After intradermal injection of ICG in the left forepaw, deeply positioned SLNs (beneath 2-cm thick chicken breast) were easily indentified in vivo and in real time. Further, we confirmed ICG uptake in axillary lymph nodes with in vivo and ex vivo fluorescence imaging. These results demonstrate the clinical potential of this hand-held photoacoustic system for facile identification and needle biopsy of SLNs for cancer staging and metastasis detection in humans.

Kim, Chulhong; Erpelding, Todd N.; Akers, Walter J.; Maslov, Konstantin; Song, Liang; Jankovic, Ladislav; Margenthaler, Julie A.; Achilefu, Samuel; Wang, Lihong V.

2011-03-01

288

NEEDLE ANATOMY CHANGES WITH INCREASING TREE AGE IN DOUGLAS FIR  

EPA Science Inventory

Morphological differences between old growth and sapling (Pseudotsuga menziesii, (Mirb.) Franco) Douglas fir trees may extend to differences in needle anatomy. We used microscopy with image analysis to compare and quantify anatomical parameters in cross-sections of previous year...

289

Quantitative CT Imaging of Interstitial Lung Diseases  

PubMed Central

Purpose High-Resolution chest CT (HRCT) is essential in the characterization of interstitial lung disease (ILD). The HRCT features of some diseases can be diagnostic. Longitudinal monitoring with HRCT can assess progression of ILD; however, subtle changes in the volume and character of abnormalities can be difficult to assess. Accuracy of diagnosis can be dependent on expertise and experience of the radiologist, pathologist or clinician. Quantitative analysis of thoracic HRCT has the potential to determine the extent of disease reproducibly, classify the types of abnormalities and automate the diagnostic process. Materials and Methods Novel software that utilizes histogram signatures to characterize pulmonary parenchyma was used to interrogate chest HRCT data, including retrospective processing of clinical CT scans and research data from the Lung Tissue Research Consortium (LTRC). Additional information including physiologic, pathologic and semi-quantitative radiologist assessment was available to allowcomparison of quantitative results with visual estimates of disease, physiologic parameters and measures of disease outcome. Results Quantitative analysis results were provided in regional volumetric quantities for statistical analysis as well as a graphical representation. Analysis suggests that quantitative HRCT analysis can serve as a biomarker with physiologic, pathologic and prognostic significance. Conclusion It is likely that quantitative analysis of HRCT can be used in clinical practice as a means to aid in identifying probable diagnosis, stratifying prognosis in early disease, and consistently determining progression of disease or response to therapy. Further optimization of quantitative techniques and longitudinal analysis of well-characterized subjects would be helpful to validate these methods. PMID:23966094

Bartholmai, Brian J; Raghunath, Sushravya; Karwoski, Ronald A; Moua, Teng; Rajagopalan, Srinivasan; Maldonado, Fabien; Decker, Paul A; Robb, Richard A

2013-01-01

290

Fatal interstitial lung disease associated with icotinib  

PubMed Central

The most serious, and maybe fatal, yet rare, adverse reaction of gefitinib and erlotinib is drug-associated interstitial lung disease (ILD), which has been often described. However, it has been less well described for icotinib, a similar orally small-molecule tyrosine kinase inhibitor (TKI). The case of a 25-year-old female patient with stage IV lung adenocarcinoma who developed fatal ILD is reported here. She denied chemotherapy, and received palliative treatment with icotinib (125 mg po, three times daily) on March 1, 2013. One month after treatment initiation, the patient complained of continuous dry cough and rapid progressive dyspnea. Forty one days after icotinib treatment, icotinib associated ILD was suspected when the patient became increasingly dyspnoeic despite of treatment of pericardial effusion, left pleural effusion and lower respiratory tract infection, and X-ray computed tomography (CT) of chest revealed multiple effusion shadows and ground-glass opacities in bilateral lungs. Then, icotinib was discontinued and intravenous corticosteroid was started (methylprednisolone 40 mg once daily, about 1 mg per kilogram) respectively. Forty three days after icotinib treatment, the patient died of hypoxic respiratory failure. ILD should be considered as a rare, but often fatal side effect associated with icotinib treatment. PMID:25590006

Zhang, Jiexia; Zhan, Yangqing; Ouyang, Ming; Qin, Yinyin; Zhou, Chengzhi

2014-01-01

291

Acute interstitial nephritis induced by Dioscorea quinqueloba  

PubMed Central

Background The use of herbal medicine may be a risk factor for the development of kidney injury, as it has been reported to cause various renal syndromes. Dioscorea quinqueloba is a medicinal herb that is used as an alternative therapy for cardiovascular disease and various medical conditions. Case presentation A 52-year-old man was admitted with complaints of skin rash and burning sensation. He had ingested a raw extract of D. quinqueloba as a traditional remedy. Laboratory tests revealed the following values: absolute eosinophil count, 900/mm3; serum creatinine level, 2.7 mg/dL; and blood urea nitrogen, 33.0 mg/dL. The immunoglobulin E level was markedly increased at 1320.0 IU/mL. Urinalysis revealed a fractional excretion of sodium of 3.77%, protein 1+, and blood 3+. Histological examination of the renal biopsy specimen showed a diffusely edematous interstitium with infiltrates composed of eosinophils, lymphocytes, and neutrophils. Conclusion Here, we present the first reported case of biopsy-proven acute interstitial nephritis following ingestion of D. quinqueloba associated with skin rash, eosinophilia, and increased plasma immunoglobulin E level. PMID:25186588

2014-01-01

292

Granular Material Flows with Interstitial Fluid Effects  

NASA Technical Reports Server (NTRS)

The research focused on experimental measurements of the rheological properties of liquid-solid and granular flows. In these flows, the viscous effects of the interstitial fluid, the inertia of the fluid and particles, and the collisional interactions of the particles may all contribute to the flow mechanics. These multiphase flows include industrial problems such as coal slurry pipelines, hydraulic fracturing processes, fluidized beds, mining and milling operation, abrasive water jet machining, and polishing and surface erosion technologies. In addition, there are a wide range of geophysical flows such as debris flows, landslides and sediment transport. In extraterrestrial applications, the study of transport of particulate materials is fundamental to the mining and processing of lunar and Martian soils and the transport of atmospheric dust (National Research Council 2000). The recent images from Mars Global Surveyor spacecraft dramatically depict the complex sand and dust flows on Mars, including dune formation and dust avalanches on the slip-face of dune surfaces. These Aeolian features involve a complex interaction of the prevailing winds and deposition or erosion of the sediment layer; these features make a good test bed for the verification of global circulation models of the Martian atmosphere.

Hunt, Melany L.; Brennen, Christopher E.

2004-01-01

293

Disorders of interstitial cells of Cajal.  

PubMed

Interstitial cells of Cajal (ICCs) have, in the past 2 decades, been recognised as important elements in the regulation of gastrointestinal motility. Specifically, they have been shown to be critical for the generation and propagation of electrical slow waves that regulate the phasic contractile activity of gastrointestinal smooth muscle, and for mediating neurotransmission from enteric motor neurons to smooth muscle cells. These different functional roles are carried out by different phenotypic classes of ICC that have discrete distributions within the tunica muscularis. Identifying the functional roles of ICC within the gut has been facilitated by studying mutant mice deficient in ICC, either as a consequence of loss of the tyrosine kinase receptor, Kit, or its ligand, stem cell factor, both of which are necessary for normal ICC development. In humans, under certain pathophysiological conditions, loss or defects in ICC networks appear to play a role in the generation of certain motility disorders. Alterations in ICC distribution have been reported in conditions such as achalasia, chronic intestinal pseudoobstruction, Hirschsprung disease, inflammatory bowel diseases, and slow transit constipation. Molecular and genetic techniques are helping researchers to determine whether defects in ICC networks are the cause of motility disorders, or whether the disrupted ICC networks are a consequence of gut dysfunction. PMID:18185068

Burns, Alan J

2007-12-01

294

Diode laser and antitumoral interstitial hyperthermia  

NASA Astrophysics Data System (ADS)

A randomized study of interstitial hyperthermia with diode laser was performed on 40 Swiss nu/nu mice. The series was divided as follows: group 1 a control group; and group 2 treated by diode laser. The tumor model was a subcutaneous HT29 colonic carcinoma treated at the same size. The diode laser (830 nm) was applied through a 300 micrometers optic fiber implanted in the tumor and delivered at a power output of 200 mW and 1800 sec exposure time (360 J). The temperature range was 46 degree(s)C in the center of tumor and 42 degree(s)C in its peripheral part. In both groups, the tumor was removed 3 days after laser treatment. The tumor volume (TV) was evaluated and compared using nonparametric tests (Kruskal Wallis). Microscopic examination of tumors showed extensive and complete necrosis in group 1. By day 30 after removal the tumoral recurrence rate was 20% in group 2 versus 55% in group 1. The technical advantages of diode laser are pointed out.

Godlewski, Guilhem; Tang, Jing; Delacretaz, Guy P.; Prudhomme, Michel; Salathe, Rene-Paul

1994-07-01

295

Fatal interstitial lung disease associated with icotinib.  

PubMed

The most serious, and maybe fatal, yet rare, adverse reaction of gefitinib and erlotinib is drug-associated interstitial lung disease (ILD), which has been often described. However, it has been less well described for icotinib, a similar orally small-molecule tyrosine kinase inhibitor (TKI). The case of a 25-year-old female patient with stage IV lung adenocarcinoma who developed fatal ILD is reported here. She denied chemotherapy, and received palliative treatment with icotinib (125 mg po, three times daily) on March 1, 2013. One month after treatment initiation, the patient complained of continuous dry cough and rapid progressive dyspnea. Forty one days after icotinib treatment, icotinib associated ILD was suspected when the patient became increasingly dyspnoeic despite of treatment of pericardial effusion, left pleural effusion and lower respiratory tract infection, and X-ray computed tomography (CT) of chest revealed multiple effusion shadows and ground-glass opacities in bilateral lungs. Then, icotinib was discontinued and intravenous corticosteroid was started (methylprednisolone 40 mg once daily, about 1 mg per kilogram) respectively. Forty three days after icotinib treatment, the patient died of hypoxic respiratory failure. ILD should be considered as a rare, but often fatal side effect associated with icotinib treatment. PMID:25590006

Zhang, Jiexia; Zhan, Yangqing; Ouyang, Ming; Qin, Yinyin; Zhou, Chengzhi; Chen, Rongchang

2014-12-01

296

Connective tissue disease-associated interstitial pneumonia and idiopathic interstitial pneumonia: similarity and difference.  

PubMed

Interstitial lung diseases (ILDs) are increasingly recognized in patients with systemic diseases. Patients with early ILD changes may be asymptomatic. Features of ILD overlap among systemic diseases and with idiopathic variety. High-resolution computed tomography plays a central role in diagnosing ILDs. Imaging features are often nonspecific. Therapy- and complication-related lung changes would pose difficulty in diagnosing and classifying an ILD. Biology and prognosis of secondary ILDs may differ between different disease-related ILDs and idiopathic variety. Combination of clinical features, serological tests, pulmonary and extrapulmonary imaging findings, and pathology findings may help to diagnose ILDs. PMID:24480141

Bryson, Thomas; Sundaram, Baskaran; Khanna, Dinesh; Kazerooni, Ella A

2014-02-01

297

Dimensionality of interstitial cluster motion in bcc-Fe  

Microsoft Academic Search

We study self-interstitial cluster migration properties, such as dimensionality of the motion and activation energy barrier, as functions of the cluster size, by means of molecular-dynamics simulations in bcc-Fe. The atomic interactions are described using a recently proposed potential, fitted to reproduce self-interstitial atom (SIA) configuration energies in close agreement with the results of ab initio calculations. We show that

D. A. Terentyev; L. Malerba; M. Hou

2007-01-01

298

Interstitial Lung Disease Induced by Drugs and Radiation  

Microsoft Academic Search

An ever-increasing number of drugs can reproduce variegated patterns of naturally occurring interstitial lung disease (ILD), including most forms of interstitial pneumonias, alveolar involvement and, rarely, vasculitis. Drugs in one therapeutic class may collectively produce the same pattern of involvement. A few drugs can produce more than one pattern of ILD. The diagnosis of drug-induced ILD (DI-ILD) essentially rests on

Philippe Camus; Annlyse Fanton; Philippe Bonniaud; Clio Camus; Pascal Foucher

2004-01-01

299

Interstitial pneumonitis in patients infected with the human immunodeficiency virus  

Microsoft Academic Search

BACKGROUND--A study was performed to identify the clinical, radiographic, and histopathological features of interstitial pneumonitis in patients infected with the human immunodeficiency virus. METHODS--A retrospective review was made of the case notes, chest radiographs, and histopathological results of seven HIV-1 antibody positive patients with symptomatic diffuse pulmonary disease and a pathological diagnosis of non-specific interstitial pneumonitis. RESULTS--All patients had dyspnoea,

M H Griffiths; R F Miller; S J Semple

1995-01-01

300

Computer Simulations of Interstitial Loop Growth Kinetics in irradiated bcc Fe  

SciTech Connect

The growth kinetics of (001) [001] interstitial loops in bcc Fe is studied by phase-field modeling. The effect of defect (vacancy/interstitial) concentration, generation, recombination, sink strength, and elastic interaction on the growth kinetics of interstitial loops is systematically simulated. Results show that the elastic interaction between the defects and interstitial loops speeds up the growth kinetics and affects the morphology of the interstitial loops. Linear growth rate, i.e., the loop average radius is linear to time, under both aging and irradiation are predicted, which is in agreement with experimental observation. The results also show that the interstitial loop growth rate, which is directly related to the sink strength of the interstitial loop for interstitials, increases linearly with the initial interstitial concentration during aging while changing logarithmically with the interstitial generation rate under irradiation.

Li, Yulan; Hu, Shenyang Y.; Henager, Charles H.; Deng, Huiqiu; Gao, Fei; Sun, Xin; Khaleel, Mohammad A.

2012-08-01

301

Computer simulations of interstitial loop growth kinetics in irradiated bcc Fe  

NASA Astrophysics Data System (ADS)

The growth kinetics of (0 0 1) [0 0 1] interstitial loops in bcc Fe is studied by phase-field modeling. The effect of defect (vacancy/interstitial) concentration, generation, recombination, sink strength, and elastic interaction on the growth kinetics of interstitial loops is systematically simulated. Results show that the elastic interaction between the defects and interstitial loops speeds up the growth kinetics and affects the morphology of the interstitial loops. Linear growth rate, i.e., the loop average radius is linear to time, under both aging and irradiation are predicted, which is in agreement with experimental observation. The results also show that the interstitial loop growth rate, which is directly related to the sink strength of the interstitial loop for interstitials, increases linearly with the initial interstitial concentration during aging while changing logarithmically with the interstitial generation rate under irradiation.

Li, Yulan; Hu, Shenyang; Henager, Charles H.; Deng, Huiqiu; Gao, Fei; Sun, Xin; Khaleel, Moe A.

2012-08-01

302

Benefits and risks of needle-knife papillotomy  

Microsoft Academic Search

Background: The objective of the present investigation was to assess the risks and benefits of pre-cutting with the needle knife at the papilla of Vater and to compare the findings with the results of classic endoscopic sphincterotomy. Methods: From January 1973 to December 1993, 2752 endoscopic cutting procedures—biliary or pancreatic sphincterotomy (EST) or needle-knife papillotomy (NKP)—were performed. Since 1981 the

Thomas Rabenstein; Thomas Ruppert; H. Thomas Schneider; Eckhart G. Hahn; Christian Ell

1997-01-01

303

Antidyslipidemic and antioxidant activity of Pinus roxburghii needles  

Microsoft Academic Search

Pinus roxburghii commonly known as chir pine contains a substance turpene, in abundance and is known for several medicinal properties. The\\u000a needles were investigated for antidyslipidemic activity in high fat diet (HFD)-fed hyperlipidemic Golden-Syrian hamsters.\\u000a The alcoholic extracts of P. roxburghii needle significantly decreased the plasma triglyceride (TG) by 38%, total cholesterol (TC) 23%, glycerol (Gly) 44%, and low\\u000a density

Anju Puri; Anuj K. Srivastava; B. Singhal; S. K. Mishra; S. Srivastava; V. Lakshmi

304

Roles of diverse fungi in larch needle-litter decomposition  

Microsoft Academic Search

Functional biodiversity of fungi in larch (Larix leptolepis) forests needle-litter decomposition was examined by a pure-culture test. Weight loss of larch-needle litter, utilization pattern of lignocellu- lose and chemical composition of remaining litter were investigated and compared for 31 isolates in 27 species of basidiomycetes and ascomycetes. Weight loss (% original weight) of litter ranged from 22.0% to 14.2%. Mean

Takashi Osono; Yu Fukasawa; Hiroshi Takeda

2003-01-01

305

Developmental regulation of interstitial cell density in bullfrog skeletal muscle.  

PubMed

Denervation of skeletal muscle results in striking connective tissue remodelling in junctional areas of muscle. Since extracellular matrix molecules mediate axonal growth and synaptic differentiation, it is likely that the interstitial cells and matrix molecules that accumulate near synaptic sites after denervation influence the regrowth and regeneration of synaptic connections. The experiments presented here addressed the question of whether the junctional connective tissue in developing bullfrog skeletal muscle was also specialized in its cellular and molecular composition. Denervation responses of muscle, such as extrajunctional sensitivity to acetylcholine, often reproduce the characteristics of developing muscle during synaptogenesis. In developing muscle, the distribution of interstitial cells was nonuniform during the period of muscle fibre birth and synaptogenesis. Interstitial cells were concentrated near synaptic sites as in denervated adult muscle. Unlike denervated adult muscle, there were no junctional accumulations of fibronectin or tenascin, matrix molecules produced by interstitial cells, in developing muscles. These results demonstrate that the junctional connective tissue in developing muscle is identified by a high density of interstitial cells that may play a role in the identification and formation of synaptic sites. Further, the junctional matrix environment of developing muscle is distinct from the matrix remodelling that occurs in response to denervation, suggesting that the matrix production by interstitial cells during development is regulated differently from that after denervation of the neuromuscular junction. PMID:9154526

Connor, E A

1997-01-01

306

Surface morphology and electrical transport of rapid thermal annealed chromium-doped indium zinc oxides: The influence of zinc interstitials and out-diffusion  

SciTech Connect

We investigate the complex impedance (CI) spectra of chromium-doped indium zinc oxide (CIZO) films with different rapid thermal annealing (RTA) temperatures. The CI spectra drawn from the impedance contributions of Zn-O and In-O bondings in CIZO films were analyzed by two sets of parallel resistance and capacitance components in series. The result demonstrates that zinc interstitials controls electron concentration and transition of electrical transport from semiconducting to metallic. At higher RTA temperature, high-density zinc interstitial promotes Zn atom diffusion from the surface, modifying surface morphology.

Hsu, C. Y., E-mail: cyhsu00@gmail.com [Physics Department, National Sun Yat-Sen University, Kaohsiung 804, Taiwan (China)

2013-12-09

307

Mass spectrometry of radicals created in plasma needle discharge  

NASA Astrophysics Data System (ADS)

We present diagnostics of the properties of a plasma needle operating at atmospheric pressure. Our configuration has additional grounded copper ring placed near the tip of the needle. Generated plasma has a larger volume and lower ignition powers with the ring. This configuration is convenient both for treatment of samples and for mass spectroscopy. Our measurements were performed on a standard size plasma needle that we originally used for the treatment of plant cells. Similar work of Stoffels et al. has been done on the `robust' version of the plasma needle that generates an elongated jet of 4 mm length and consumes higher powers. After some efforts we were able to make plasma needle to operate for conditions similar to those used during the treatments of biological samples. Hiden HPR60 mass analyzer was used to obtain the mass spectra. Plasma mode transition was observed for higher values of power transmitted to plasma. Concentrations of N, O, NO, NO2 and O3 were measured. We have also measured spatial profiles of emission and voltage and current waveforms by derivative probes placed close to the tip of the needle.

Lazovic, Sasa; Puac, Nevena; Malovic, Gordana; Djordjevic, Antonije; Petrovic, Zoran Lj.

2008-10-01

308

Retained surgical sponges, needles and instruments  

PubMed Central

Introduction Retained sponges and instruments (RSI) due to surgery are a recognised medical ‘never event’ and have catastrophic implications for patients, healthcare professionals and medical care providers. The aim of this review was to elucidate the extent of the problem of RSI and to identify preventative strategies. Methods A comprehensive literature search was performed on MEDLINE®, Embase™, the Science Citation Index and Google™ Scholar for articles published in English between January 2000 and June 2012. Studies outlining the incidence, risk, management and attempts to prevent RSI following surgical intervention were retrieved. Results The overall incidence of RSI is low although its incidence is substantially higher in operations performed on open cavities. Sponges are the most commonly retained item when compared with needles and instruments. Clinical presentation is varied, leading to avoidable morbidity, and the error is indefensible medicolegally. Risk factors include emergency operations, operations involving unexpected change in procedure, raised body mass index, and a failure to perform accurate sponge and instrument counts. The existing strategy for prevention is manual counting of sponges and instruments undertaken by surgical personnel. This, however, is fallible. Computer assisted counting of sponges using barcodes and gauze sponges tagged with a radiofrequency identification device aiding manual counting have been trialled recently, with success. Conclusions Vigilance among operating theatre personnel is paramount if RSI is to be prevented. Prospective multicentre trials to assess efficacy of new technologies aiding manual counting should be undertaken if this medical error is to be eliminated completely. PMID:23484986

Hariharan, D

2013-01-01

309

High-temperature calcined fullerene nanowhiskers as well as long needle-like multi-wall carbon nanotubes have abilities to induce NLRP3-mediated IL-1? secretion.  

PubMed

Because multi-wall carbon nanotubes (MWCNTs) have asbestos-like shape and size, concerns about their pathogenicity have been raised. Contaminated metals of MWCNTs may also be responsible for their toxicity. In this study, we employed high-temperature calcined fullerene nanowhiskers (HTCFNWs), which are needle-like nanofibers composed of amorphous carbon having similar sizes to MWCNTs but neither metal impurities nor tubular structures, and investigated their ability to induce production a major proinflammatory cytokine IL-1? via the Nod-like receptor pyrin domain containing 3 (NLRP3)-containing flammasome-mediated mechanism. When exposed to THP-1 macrophages, long-HTCFNW exhibited robust IL-1? production as long and needle-like MWCNTs did, but short-HTCFNW caused very small effect. IL-1? release induced by long-HTCFNW as well as by long, needle-like MWCNTs was abolished by a caspase-1 inhibitor or siRNA-knockdown of NLRP3, indicating that NLRP3-inflammasome-mediated IL-1? production by these carbon nanofibers. Our findings indicate that the needle-like shape and length, but neither metal impurities nor tubular structures of MWCNTs were critical to robust NLRP3 activation. PMID:25181346

Cui, Hongyan; Wu, Weijia; Okuhira, Keiichiro; Miyazawa, Kun'ichi; Hattori, Takayuki; Sai, Kimie; Naito, Mikihiko; Suzuki, Kazuhiro; Nishimura, Tetsuji; Sakamoto, Yoshimitsu; Ogata, Akio; Maeno, Tomokazu; Inomata, Akiko; Nakae, Dai; Hirose, Akihiko; Nishimaki-Mogami, Tomoko

2014-09-26

310

Percutaneous CT-Guided Core Needle Biopsy Versus Fine Needle Aspiration in Diagnosing Pneumonia and Mimics of Pneumonia  

SciTech Connect

The purpose of this study was to determine the diagnostic value of percutaneous core needle biopsy (CNB) relative to fine needle aspiration (FNA) in patients with pneumonia and pneumonia mimics. In this prospective study we present our experience with 48 thoracic FNAs and CNBs carried out on 48 patients with pneumonia and pneumonia mimics. Samples were obtained from all patients using both CNB (with an automated 18-G core biopsy needle and a gun) and FNA (with a 22-G needle). A specific diagnosis was made in 10/48 cases (20.83%) by FNA and in 42/48 (87.5%) by CNB. The main complications encountered were pneumothorax (n = 4) and hemoptysis (n = 2), yielding a total complication rate of 12.5%. We concluded that CNB using an automated biopsy gun results in a higher diagnostic accuracy for pneumonia and pneumonia mimic biopsies than FNA. Complications should be considered and proper patient observation should follow the procedure.

Thanos, Loukas; Galani, Panagiota, E-mail: paga@hol.gr; Mylona, Sophia; Pomoni, Maria; Mpatakis, Nikolaos [Helenic Red Cross Hospital, Radiology Department (Greece)

2004-08-15

311

Behavior of Tip-Steerable Needles in ex vivo and in vivo Tissue  

PubMed Central

Robotic needle steering is a promising technique to improve the effectiveness of needle-based clinical procedures, such as biopsies and ablation, by computer-controlled, curved insertions of needles within solid organs. In this paper, we explore the capabilities, challenges, and clinical relevance of asymmetric-tip needle steering though experiments in ex vivo and in vivo tissue. We evaluate the repeatability of needle insertion in inhomogeneous biological tissue and compare ex vivo and in vivo needle curvature and insertion forces. Steerable needles curved more in kidney than in liver and prostate, likely due to differences in tissue properties. Pre-bent needles produced higher insertion forces in liver and more curvature in vivo than ex vivo. When compared to straight stainless steel needles, steerable needles did not cause a measurable increase in tissue damage and did not exert more force during insertion. The minimum radius of curvature achieved by pre-bent needles was 5.23 cm in ex vivo tissue, and 10.4 cm in in vivo tissue. The curvatures achieved by bevel tip needles were negligible for in vivo tissue. The minimum radius of curvature for bevel tip needles in ex vivo tissue was 16.4 cm; however, about half of the bevel tip needles had negligible curvatures. We also demonstrate a potential clinical application of needle steering by targeting and ablating overlapping regions of cadaveric canine liver. PMID:22711767

Majewicz, Ann; Marra, Steven P.; van Vledder, Mark G.; Lin, MingDe; Choti, Michael A.; Song, Danny Y.; Okamura, Allison M.

2012-01-01

312

Heating of industrial sewing machine needles: FEA model and verification using IR radiometry  

NASA Astrophysics Data System (ADS)

With the use of synthetic fabrics and threads in high speed sewing, needle heating due to friction between the needle and the fabric becomes a serious problem which limits further increase of the sewing speed. The high temperature in the needle can accelerate thread wear, cause wear at the needle eye, and damage the thread. It can also scorch the fabric, as well as temper and weaken the needle itself. Experimental methods, such as: infrared radiometry, infrared pyrometry, etc., have been applied to analyze this problem in previous studies. They revealed some important factors that affect the needle peak steady state temperature. In this study the numerical (FEA) model developed to simulate the needle heating is fine tuned and verified via infrared radiometry. The FEA model incorporates detailed needle geometry and the effects of thread on needle heating. It deals with a transient heat transfer process with time and position dependent boundary conditions. It correlates various important factors that affect the needle heating, such as needle characteristics, fabric properties, and sewing conditions to the needle temperature distribution. Given various needle geometries, sewing conditions, and fabric properties, the model can simulate the needle heating process, including the initial heating phase and the steady state. It can also predict the temperature distribution in the needle as well as the time to reach steady state. The trends of the simulation results correlate well with experiments.

Li, Qinwen; Liasi, Evangelos; Simon, Daniel L.; Du, Ruxu; Bujas-Dimitrijevic, Jasmina; Chen, Anshi

1999-03-01

313

Hard metal lung disease in an oil industry worker.  

PubMed

Hard metal lung disease, which manifests as giant cell interstitial pneumonia, is caused by exposure to hard metal dust. We report the case of an oil industry worker diagnosed with hard metal lung disease. The diagnosis was based on the clinical, radiological and anatomopathological analysis, as well as on pulmonary function testing. PMID:20126930

Bezerra, Patrícia Nunes; Vasconcelos, Ana Giselle Alves; Cavalcante, Lílian Loureiro Albuquerque; Marques, Vanessa Beatriz de Vasconcelos; Nogueira, Teresa Neuma Albuquerque Gomes; Holanda, Marcelo Alcantara

2009-12-01

314

Spinal anaesthesia for caesarean section: comparison of 22-gauge and 25-gauge Whitacre needles with 26-gauge Quincke needles.  

PubMed

We have studied 150 women undergoing elective Caesarean section under spinal anaesthesia. They were allocated randomly to have a 22-gauge Whitacre, a 25-gauge Whitacre or a 26-gauge Quincke needle inserted into the lumbar subarachnoid space. The groups were compared for ease of insertion, number of attempted needle insertions before identification of cerebrospinal fluid, quality of subsequent analgesia and incidence of postoperative complications. There were differences between groups, but they did not reach statistical significance. Postdural puncture headache (PDPH) was experienced by one mother in the 22-gauge Whitacre group, none in the 25-gauge Whitacre group and five in the 26-gauge Quincke group. Five of the six PDPH occurred after a single successful needle insertion. Seven of the 15 mothers in whom more than two needle insertions were made experienced backache, compared with 12 of the 129 receiving two or less (P < 0.001). We conclude that the use of 22- and 25-gauge Whitacre needles in elective Caesarean section patients is associated with a low incidence of PDPH and that postoperative backache is more likely when more than two attempts are made to insert a spinal needle. PMID:1467102

Shutt, L E; Valentine, S J; Wee, M Y; Page, R J; Prosser, A; Thomas, T A

1992-12-01

315

Fact Sheet: Needle Recapping Although recapping needles is not recommended in the lab, there are times in which it must be done. In  

E-print Network

it on securely using only one hand. 2. Using a sterile 50 mL centrifuge tube or Styrofoam rack: Place an open centrifuge tube or rack so that the needle can be inserted into it and the cap and secured by firmly pushing the needle downward into it. There are also commercial needle recapping devices available

Rubloff, Gary W.

316

Microbial translocation of needle-free versus traditional needle injection-enhanced beef strip loins.  

PubMed

Our objective was to determine the effects of needle-free (NF) versus needle injection (N) enhancement on microbial translocation of generic Escherichia coli in beef strip loins. Fifteen longissimus muscles (LM) were obtained and halved. Surfaces were inoculated with generic E. coli at a level of 10(6) CFU/cm(2) (three replications of five strip loins). LM halves were injection-enhanced with a phosphate and salt solution with either NF or N injection. After injection, two cores were taken from each LM half and sliced cross-sectionally at depths of 2-mm (surface), 1, 3, and 5 cm. The paired samples were stomached, serially diluted, and plated. Surface samples from N-injected muscles had lower (P<0.05) E. coli counts (2.79 versus 3.23 log CFU/g for NF). Also, the 3- and 5-cm depth samples from N injection had the least (P<0.05) E. coli contamination (1.69 versus 2.12 CFU/g for NF). Although traditional N injection resulted in approximately 0.5 log CFU/g less microbial contamination at all depths, because the level of contamination was extremely high, the difference in the treatments could arguably be of little practical importance in terms of safety. PMID:20374776

Ray, A N; Dikeman, M E; Crow, B A; Phebus, R K; Grobbel, J P; Hollis, L C

2010-01-01

317

Intracavitary combined with CT-guided interstitial brachytherapy for locally advanced uterine cervical cancer: introduction of the technique and a case presentation.  

PubMed

We report a new technique of brachytherapy consisting of intracavitary combined with computed tomography (CT)-guided interstitial brachytherapy for locally advanced cervical cancer. A Fletcher-Suit applicator and trocar point needles were used for performing high-dose rate brachytherapy under in-room CT guidance. First, a tandem and ovoids were implanted into the patient's vagina and uterus by conventional brachytherapy method. Based on clinical examination and MRI/CT imaging, operating radiation oncologists decided the positions of insertion in the tumor and the depth of the needles from the upper surface of the ovoid. Insertion of the needle applicator was performed from the vaginal vault inside the ovoid within the tumor under CT guidance. In treatment planning, dwell positions and time adaptations within the tandem and ovoids were performed first for optimization based on the Manchester system, and then stepwise addition of dwell positions within the needle was continued. Finally, dwell positions and dwell weights were manually modified until dose-volume constraints were optimally matched. In our pilot case, the dose of D90 to high-risk clinical target volume was improved from 3.5 Gy to 6.1 Gy by using our hybrid method on the dose-volume histogram. D1cc of the rectum, bladder and sigmoid colon by our hybrid method was 4.8 Gy, 6.4 Gy and 3.5 Gy, respectively. This method consists of advanced image-guided brachytherapy that can be performed safely and accurately. This approach has the potential of increasing target coverage, treated volume, and total dose without increasing the dose to organs at risk. PMID:21293072

Wakatsuki, Masaru; Ohno, Tatsuya; Yoshida, Daisaku; Noda, Shin-ei; Saitoh, Jun-ichi; Shibuya, Kei; Katoh, Hiroyuki; Suzuki, Yoshiyuki; Takahashi, Takeo; Nakano, Takashi

2011-01-01

318

Bronchiolitis interstitial pneumonitis: a pathologic study of 31 lung biopsies with features intermediate between bronchiolitis obliterans organizing pneumonia and usual interstitial pneumonitis, with clinical correlation  

Microsoft Academic Search

Bronchiolitis combined with interstitial pneumonitis generally has been equated with bronchiolitis obliterans organizing pneumonia (BOOP). We describe our experience with lung biopsies that had both bronchiolar and interstitial diseases. We studied 31 patients who had respiratory difficulty leading to open lung biopsy, which showed a combination of both prominent bronchiolitis and prominent interstitial pneumonitis. We compared these cases clinically and

Eugene J. Mark; Ruchira Ruangchira-urai

2008-01-01

319

Abnormal urothelial HLA-DR expression in interstitial cystitis.  

PubMed Central

Interstitial cystitis is a chronic inflammatory disorder of the urinary bladder that predominantly afflicts middle-age women. The end stage of the disease is ulceration of the urothelium, the so-called Hunner's ulcer. The aetiology of interstitial cystitis remains obscure. We have studied bladder biopsies from 22 cases of interstitial cystitis and control groups consisting of six cases of bacterial cystitis and eight healthy women. Indirect immunofluorescence was performed on the biopsies using murine MoAbs to human HLA class I molecules, and class II molecules, HLA-DP, HLA-DQ and HLA-DR. In interstitial cystitis, bacterial cystitis and normal controls most cells expressed HLA class I products. In six cases of interstitial cystitis and one case of bacterial cystitis there was evidence of HLA class I hyperexpression. In normal bladder and bacterial cystitis HLA class II expression was restricted to submucosal dendritic cells, Langerhans cells macrophages, vascular endothelial cells and activated lymphocytes. All but two cases of interstitial cystitis showed surface expression of HLA-DR (but not HLA-DP or DQ). In all cases of interstitial cystitis there was an increase in the numbers of macrophages, activated lymphocytes and vascular endothelial cells expressing HLA class II molecules within the submucosa. These findings provide further evidence for the importance of inappropriate HLA molecule expression in a disease suspected of having an autoimmune pathogenesis and where cellular autoimmune mechanisms play a decisive role in the destruction of the target cells--the bladder urothelium. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 PMID:1544229

Christmas, T J; Bottazzo, G F

1992-01-01

320

From the Cover: Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies  

NASA Astrophysics Data System (ADS)

Arrays of micrometer-scale needles could be used to deliver drugs, proteins, and particles across skin in a minimally invasive manner. We therefore developed microfabrication techniques for silicon, metal, and biodegradable polymer microneedle arrays having solid and hollow bores with tapered and beveled tips and feature sizes from 1 to 1,000 ?m. When solid microneedles were used, skin permeability was increased in vitro by orders of magnitude for macromolecules and particles up to 50 nm in radius. Intracellular delivery of molecules into viable cells was also achieved with high efficiency. Hollow microneedles permitted flow of microliter quantities into skin in vivo, including microinjection of insulin to reduce blood glucose levels in diabetic rats. transdermal drug delivery | skin | microelectromechanical systems | solid microneedle | hollow needle injection

McAllister, Devin V.; Wang, Ping M.; Davis, Shawn P.; Park, Jung-Hwan; Canatella, Paul J.; Allen, Mark G.; Prausnitz, Mark R.

2003-11-01

321

Atomic model of the type III secretion system needle  

PubMed Central

Pathogenic bacteria using a type III secretion system (T3SS)1,2 to manipulate host cells cause many different infections including Shigella dysentery, typhoid fever, enterohaemorrhagic colitis and bubonic plague. An essential part of the T3SS is a hollow needle-like protein filament through which effector proteins are injected into eukaryotic host cells3–6. Currently, the three-dimensional structure of the needle is unknown because it is not amenable to X-ray crystallography and solution NMR, as a result of its inherent non-crystallinity and insolubility. Cryo-electron microscopy combined with crystal or solution NMR subunit structures has recently provided a powerful hybrid approach for studying supramolecular assemblies7–12, resulting in low-resolution and medium-resolution models13–17. However, such approaches cannot deliver atomic details, especially of the crucial subunit–subunit interfaces, because of the limited cryo-electron microscopic resolution obtained in these studies. Here we report an alternative approach combining recombinant wild-type needle production, solid-state NMR, electron microscopy and Rosetta modelling to reveal the supramolecular interfaces and ultimately the complete atomic structure of the Salmonella typhimurium T3SS needle. We show that the 80-residue subunits form a right-handed helical assembly with roughly 11 subunits per two turns, similar to that of the flagellar filament of S. typhimurium. In contrast to established models of the needle in which the amino terminus of the protein subunit was assumed to be ?-helical and positioned inside the needle, our model reveals an extended amino-terminal domain that is positioned on the surface of the needle, while the highly conserved carboxy terminus points towards the lumen. PMID:22699623

Loquet, Antoine; Sgourakis, Nikolaos G.; Gupta, Rashmi; Giller, Karin; Riedel, Dietmar; Goosmann, Christian; Griesinger, Christian; Kolbe, Michael; Baker, David; Becker, Stefan; Lange, Adam

2013-01-01

322

Atomic model of the type III secretion system needle.  

PubMed

Pathogenic bacteria using a type III secretion system (T3SS) to manipulate host cells cause many different infections including Shigella dysentery, typhoid fever, enterohaemorrhagic colitis and bubonic plague. An essential part of the T3SS is a hollow needle-like protein filament through which effector proteins are injected into eukaryotic host cells. Currently, the three-dimensional structure of the needle is unknown because it is not amenable to X-ray crystallography and solution NMR, as a result of its inherent non-crystallinity and insolubility. Cryo-electron microscopy combined with crystal or solution NMR subunit structures has recently provided a powerful hybrid approach for studying supramolecular assemblies, resulting in low-resolution and medium-resolution models. However, such approaches cannot deliver atomic details, especially of the crucial subunit-subunit interfaces, because of the limited cryo-electron microscopic resolution obtained in these studies. Here we report an alternative approach combining recombinant wild-type needle production, solid-state NMR, electron microscopy and Rosetta modelling to reveal the supramolecular interfaces and ultimately the complete atomic structure of the Salmonella typhimurium T3SS needle. We show that the 80-residue subunits form a right-handed helical assembly with roughly 11 subunits per two turns, similar to that of the flagellar filament of S. typhimurium. In contrast to established models of the needle in which the amino terminus of the protein subunit was assumed to be ?-helical and positioned inside the needle, our model reveals an extended amino-terminal domain that is positioned on the surface of the needle, while the highly conserved carboxy terminus points towards the lumen. PMID:22699623

Loquet, Antoine; Sgourakis, Nikolaos G; Gupta, Rashmi; Giller, Karin; Riedel, Dietmar; Goosmann, Christian; Griesinger, Christian; Kolbe, Michael; Baker, David; Becker, Stefan; Lange, Adam

2012-06-14

323

Part IB Metals and Alloys Course A: Worked Examples (7-19)  

E-print Network

energy for the migration of the interstitial atom. Explain why when substitutional solutes diffusingPart IB Metals and Alloys Course A: Worked Examples (7-19) H. K. D. H. Bhadeshia Download postscript file Download PDF file Examples 1-6 Question 7 An interstitial solute diffuses through a 0.25 mm

Cambridge, University of

324

THE ELECTRONIC STRUCTURE OF POINT DEFECTS IN METALS By A. SEEGER,  

E-print Network

of the electronic struc- ture of copper than a substitutional Zn or Au atom. An interstitial Cu atom in a Cu crystal, In a generalized sense, a metal containing point- defects (vacancies, divacancies, interstitials) may be considered as a dilute alloy. The fundamental problems in determining the electronic structure of an impurity

Boyer, Edmond

325

Fusion of electromagnetic trackers to improve needle deflection estimation: simulation study.  

PubMed

We present a needle deflection estimation method to anticipate needle bending during insertion into deformable tissue. Using limited additional sensory information, our approach reduces the estimation error caused by uncertainties inherent in the conventional needle deflection estimation methods. We use Kalman filters to combine a kinematic needle deflection model with the position measurements of the base and the tip of the needle taken by electromagnetic (EM) trackers. One EM tracker is installed on the needle base and estimates the needle tip position indirectly using the kinematic needle deflection model. Another EM tracker is installed on the needle tip and estimates the needle tip position through direct, but noisy measurements. Kalman filters are then employed to fuse these two estimates in real time and provide a reliable estimate of the needle tip position, with reduced variance in the estimation error. We implemented this method to compensate for needle deflection during simulated needle insertions and performed sensitivity analysis for various conditions. At an insertion depth of 150 mm, we observed needle tip estimation error reductions in the range of 28% (from 1.8 to 1.3 mm) to 74% (from 4.8 to 1.2 mm), which demonstrates the effectiveness of our method, offering a clinically practical solution. PMID:23674421

Sadjadi, Hossein; Hashtrudi-Zaad, Keyvan; Fichtinger, Gabor

2013-10-01

326

Needle with a Novel Attachment versus Conventional Screw-Thread Needles: A Preference and Ease-of-Use Test among Children and Adolescents with Diabetes  

PubMed Central

Background This usability test investigated the overall preference and usability of the novel NovoTwist® insulin pen needle versus conventional screw-thread needles, when used with Next Generation FlexPen®, in children and adolescents with diabetes. Methods This was an open-label, randomized, crossover usability test in children and adolescents with type 1 diabetes who administered insulin with an insulin pen. Test needles were NovoTwist and the participant’s current screw-thread needle (or NovoFine® needle). Following instruction, participants attached the needle to Next Generation FlexPen, made an injection into a foam cushion, and detached the needle. This procedure was conducted three times with both needles in a random order. Responses to 13 questions on user experience with each needle (including overall preference, ease of attachment/detachment of needle/cap, handling, learning, confidence in attachment, and convenience of use) were subsequently recorded on a six-point rating scale (1 = very difficult; 6 = very easy). Results Fifteen children aged ?6 to ?12 years and 15 adolescents aged ?13 to ?17 years participated in the test. A significantly higher proportion of children and adolescents (77%) indicated that they would prefer to use NovoTwist compared with screw-thread needles (p = .005). NovoTwist was preferred by most children and adolescents for overall ease of use (77%; p = .005), for ease of attachment (87%; p < .001) and detachment (83%; p < .001), and as the most appropriate needle to handle for daily injections (73%; p = .016). The mean rating for confidence in correct needle attachment was not significantly different between the two needle types. Seven out of eight parents of children who required assistance for their daily insulin injections stated that they would be “very likely” to allow their child to attach NovoTwist. Conclusions These factors may promote confidence in this needle, and thus in self-injecting, among younger patients and their parents. PMID:22226269

Hofman, Paul; Lilleøre, Søren Kruse; Ter-Borch, Gitte

2011-01-01

327

Biomonitoring of air quality in the Cologne conurbation using pine needles as a passive sampler—Part I: magnetic properties  

NASA Astrophysics Data System (ADS)

High resolution temporal and spatial control of atmospheric pollutants is of crucial importance for environmental health monitoring. Passive sampling using natural vegetation biomonitoring allows acquisition of well-defined samples at affordable costs. We here present results from a study conducted in the conurbation of Cologne, Germany, based on airborne pollutants accumulated on pine needles. This integrated study includes (i) the microscopic analysis of pine needles and analysis of their magnetic properties, (ii) PAH, and (iii) selected trace elements (Fe, Cd, Pb, Ni, Cr, Cu). A major proportion of atmospheric pollutants is bound to particles, for which in part I of the study we present data on magnetic susceptibility, remanence measurements (IRM, ARM) and total Fe content. SEM-analysis indicates that particles accumulated on needles are mostly <2.5 ?m in diameter and comprise pollen or spores, mineral dust and silica-glassy or metallic spheroids. The latter were identified as magnetite with minor pyrrhotite. These particles derive from combustion of coal in power plants or fuels in vehicular engines. A close correlation of magnetic properties (susceptibility, SIRM, ARM) and Fe content shows that non-destructive, time-efficient enviromagnetics of needles serves as an excellent proxy for biomonitoring of combustion pollutants. Their spatial distribution within the conurbation of Cologne was determined for 43 locations integrated in a GIS-database. The dominant sources of fine metallic particulates (PM 2.5) are emissions from road traffic, including fuel combustion, corrosion and brake-wear and from railroad and tram traffic preferentially due to material wear. Parks, forests and agricultural areas show the lowest levels of pollution by magnetic particles, followed by residential areas. This implies that traffic emissions with short transportation distances (<1.0 km) are dominant in the Cologne conurbation, whereas the contribution from power plants is negligible.

Urbat, M.; Lehndorff, E.; Schwark, L.

328

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.  

PubMed Central

We present a cascade of proteolytic events catalyzed by the proteases secreted by cultured keratinocytes and fibroblasts that results in the activation of interstitial procollagenase. Cultured human skin fibroblasts constitutively secrete interstitial collagenase and stromelysin as proenzymes. In contrast, interstitial collagenase found in serum-free skin organ culture conditioned medium is activated. Cocultivation of the major cellular components of skin organ culture, dermal fibroblasts and epidermal keratinocytes, induces activation of interstitial procollagenase and prostromelysin in the presence of plasminogen. This activation occurs through a urokinase-dependent pathway where added keratinocytes secrete the plasminogen activator urokinase, which converts plasminogen into plasmin. Plasmin is capable of activating purified procollagenase and prostromelysin. Plasmin-dependent activation of procollagenase generates an enzyme species, by amino-terminal processing, identical to those generated by limited proteolysis with trypsin or treatment with organomercurial compounds. Catalytic amounts of activated stromelysin can in turn convert plasmin- or trypsin-activated collagenase into a fully active enzyme by removal of approximately 15 amino acid residues from the carboxyl end of the enzyme. This results in a 5- to 8-fold increase in collagenase specific activity that is due to its proteolytic cleavage and not to the presence of the activator stromelysin. Stromelysin alone in both pro- and activated forms is not capable of efficient activation of human fibroblast interstitial procollagenase. Images PMID:2468156

HE, C S; Wilhelm, S M; Pentland, A P; Marmer, B L; Grant, G A; Eisen, A Z; Goldberg, G I

1989-01-01

329

Interstitial pneumonitis after acetylene welding: a case report.  

PubMed

Acetylene is a colorless gas commonly used for welding. It acts mainly as a simple asphyxiant. In this paper, however, we present a patient who developed a severe interstitial pneumonitis after acetylene exposure during aluminum welding. A 44-year old man was welding with acetylene, argon and aluminum electrode sticks in a non-ventilated aluminum tank for 2 h. Four hours after welding dyspnea appeared and 22 h later he was admitted at the Emergency Department due to severe respiratory insufficiency with pO2 = 6.7 kPa. Chest X-ray showed diffuse interstitial infiltration. Pulmonary function and gas diffusion tests revealed a severe restriction (55% of predictive volume) and impaired diffusion capacity (47% of predicted capacity). Toxic interstitial pneumonitis was diagnosed and high-dose systemic corticosteroid methylprednisolone and inhalatory corticosteroid fluticasone therapy was started. Computed Tomography (CT) of the lungs showed a diffuse patchy ground-glass opacity with no signs of small airway disease associated with interstitial pneumonitis. Corticosteroid therapy was continued for the next 8 weeks gradually reducing the doses. The patient's follow-up did not show any deterioration of respiratory function. In conclusion, acetylene welding might result in severe toxic interstitial pneumonitis that improves after an early systemic and inhalatory corticosteroid therapy. PMID:24658888

Brvar, Miran

2014-01-01

330

Diffusion of He Interstitials and He Clusters in ?-Fe  

SciTech Connect

The accumulation of He atoms in materials will significantly degrade the mechanical properties of materials; therefore, understanding the properties of He interstitials and their clusters in materials is of fundamental importance within a fusion reactor environment. The diffusion properties of single He interstitials and He clusters in the bulk and grain boundaries of ?-Fe are being studied using molecular dynamics with a new Fe?He potential. It is found that the migration barrier for a single He interstitial in the bulk is very low, which is consistent with the result obtained using ab initio methods. Large He clusters can cause Fe self-interstitial atoms (SIA) to be formed, which can be trapped by the resulting vacancy, forming a He-vacancy complex. It is found that for He interstitials in grain boundaries (GBs), the He migration is one-dimensional in a ?11 GB, while it is two-dimensional in a ?3 GB at 600 K and three-dimensional at higher temperatures.

Deng, Huiqiu; Gao, Fei; Heinisch, Howard L.; Kurtz, Richard J.

2011-03-25

331

Evaluation of an automatic needle-loading system.  

PubMed

The purpose of this paper is to evaluate the dosimetric capabilities and the radiation protection (RP) performance of a new automatic needle-loading system for permanent prostate implants, the Isoloader (Mentor Corp.). The unit has been used in more than 100 clinical cases at our institution. The Isoloader is a computerized workstation that allows automated seed testing by a solid-state CdZnTe radiation detector and loading in surgical needles. The seeds are received in a shielded and ready-to-use cartridge. Radiation protection measurements were done on a cartridge filled with 67 (125)I seeds and during dosimetric seed verification and needle loading. The reproducibility of the detector was tested and its accuracy was determined by comparison to specified activities of six calibration seeds and to their measurements in a calibrated well-chamber (WC). Finally, the times required to complete dosimetric verification and needle loading were evaluated. The cartridge was found to be adequately shielded, since no significant amount of radiation was detected around it. Radiation during seed assay was found to be worst at the cartridge's bottom, where it has a value of 15.2 microSv/h (1.4 microSv/h at 10 cm). For the needle-loading task, measurements were performed with a typical needle (three seeds) at the shielded needle holder surface yielding 307.2 microSv/h (8.3 microSv/h at 20 cm). Seed dosimetric verification takes an average of 15 s/seed, while it takes a mean time of 50 s/needle to complete the loading task. Measurements of the six seed activities were within 0.65% of the ordered activities and 1.9% higher on average than those from the WC (min = 0.7%; max = 3.5%). The reproducibility of the measurements of the CdZnTe detector was excellent, with an average of 0.01% of deviation from a reference measurement (N = 120; = 1.9%). We therefore conclude that the Isoloader is a safe, fast, and effective needle-loading system. PMID:15738915

Morrier, Janelle; Varfalvy, Nicolas; Chrétien, Mario; Beaulieu, Luc

2004-01-01

332

Hard metal lung disease and pneumothorax.  

PubMed

This case report describes a case of spontaneous pneumothorax in a metal grinder that failed to resolve with medical management. A lung biopsy taken during the subsequent thoracotomy revealed changes that were characteristic of giant cell interstitial pneumonia, as seen in hard metal disease. Pneumothorax has been described in many forms of interstitial lung disease but not in this type of occupational disease. Awareness of this possible association can result in: (1) the removal of an affected worker from his adverse work environment before advanced disease develops; and (2) the safe control of the work environment, to the advantage of other similarly exposed workers. PMID:9122508

Wahbi, Z K; Arnold, A G; Taylor, A J

1997-02-01

333

An allelopathic substance in red pine needles (Pinus densiflora).  

PubMed

Aqueous methanol extracts of red pine (Pinus densiflora) needles inhibited the growth of roots and shoots of cress (Lepidium sativum), lettuce (Lactuca sativa), alfalfa (Medicago sativa), ryegrass (Lolium multiflorum), timothy (Pheleum pratense), Digitaria sanguinalis and Echinochloa crus-galli. Increasing the extract concentration increased inhibition, suggesting that the pine needles may have growth inhibitory substances and possess allelopathic potential. The aqueous methanol extract of the pine needles was purified, and a main inhibitory substance was isolated and determined by spectral data as 9alpha,13beta-epidioxyabeit-8(14)en-18-oic acid. This substance inhibited root and shoot growth of cress and Echinochloa crus-galli seedlings at concentrations greater than 0.1 mM. The endogenous concentration of the substance was 0.13 mmol/kg pine needle. These results suggest that 9alpha,13beta-epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory effect of the pine needles and may play an important role in the allelopathy of red pine. PMID:18755523

Kato-Noguchi, Hisashi; Fushimi, Yoshiko; Shigemori, Hideyuki

2009-03-01

334

Numerical description of discharge characteristics of the plasma needle  

SciTech Connect

The plasma needle is a small atmospheric, nonthermal, radio-frequency discharge, generated at the tip of a needle, which can be used for localized disinfection of biological tissues. Although several experiments have characterized various qualities of the plasma needle, discharge characteristics and electrical properties are still not well known. In order to provide initial estimates on electrical properties and quantities such as particle densities, we employed a two-dimensional, time-dependent fluid model to describe the plasma needle. In this model the balance equation is solved in the drift-diffusion approach for various species and the electron energy, as well as Poisson's equation. We found that the plasma production occurs in the sheath region and results in a steady flux of reactive species outwards. Even at small (<0.1%) admixtures of N{sub 2} to the He background, N{sub 2}{sup +} is the dominant ion. The electron density is typically 10{sup 11} cm{sup -3} and the dissipated power is in the order of 10 mW. These results are consistent with the experimental data available and can give direction to the practical development of the plasma needle.

Brok, W.J.M.; Bowden, M.D.; Dijk, J. van; Mullen, J.J.A.M. van der; Kroesen, G.M.W. [Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven (Netherlands)

2005-07-01

335

Needle-tip localization using an optical fibre hydrophone  

NASA Astrophysics Data System (ADS)

Ultrasound imaging is frequently used for guiding needles during minimally invasive procedures, but accurate identification of the needle tips can be challenging, even for experienced practitioners. In this study, a novel method for tracking needles inside the human body was developed. This method, called ultrasonic device tracking (UDT), involved the detection of ultrasound pulses from the external imaging probe with an optical fibre hydrophone integrated into the needle cannula. Two methods for estimating the needle tip position that were based on the maximum and the centroid of the optical fibre hydrophone signal were tested. The variability of the position estimates is measured at different distances to the electronic focus. The maximum longitudinal variability was less than 80 ?m for all distances. The lateral variability remains below 500 ?m in a 20 mm region around the focus, but increases up to several mm away from the electronic focus. In the close proximity of the electronic focus, the lateral and longitudinal variability lower down to 22 ?m and less. This study suggests that UDT allows for safer and more efficient procedures in a manner that is compatible with the current clinical workflow.

Mari, Jean Martial; West, Simeon; Beard, Paul C.; Desjardins, Adrien E.

2014-02-01

336

Development of Needle Insertion Manipulator for Central Venous Catheterization  

NASA Astrophysics Data System (ADS)

Central venous catheterization is a procedure, which a doctor insert a catheter into the patient’s vein for transfusion. Since there are risks of bleeding from arterial puncture or pneumothorax from pleural puncture. Physicians are strictly required to make needle reach up into the vein and to stop the needle in the middle of vein. We proposed a robot system for assisting the venous puncture, which can relieve the difficulties in conventional procedure, and the risks of complication. This paper reports the design structuring and experimental results of needle insertion manipulator. First, we investigated the relationship between insertion force and angle into the vein. The results indicated that the judgment of perforation using the reaction force is possible in case where the needling angle is from 10 to 20 degree. The experiment to evaluate accuracy of the robot also revealed that it has beyond 0.5 mm accuracy. We also evaluated the positioning accuracy in the ultrasound images. The results displays that the accuracy is beyond 1.0 mm and it has enough for venous puncture. We also carried out the venous puncture experiment to the phantom and confirm our manipulator realized to make needle reach up into the vein.

Kobayashi, Yo; Hong, Jaesung; Hamano, Ryutaro; Hashizume, Makoto; Okada, Kaoru; Fujie, Masakatsu G.

337

Contributions of deposited particles to pine needle polycyclic aromatic hydrocarbons.  

PubMed

The contributions of deposited particles (P) to polycyclic aromatic hydrocarbon (PAH) levels in pine (Cedrus deodar) needles sampled from the Dalian region were evaluated by washing off the particles from pine needle surfaces. P values ranged from 4.4 +/- 2.2% for fluorene to 69.9 +/- 4.0% for indeno(1,2,3-cd)pyrene, and positively correlated with the logarithm of octanol-air partition coefficients (log K OA) of each PAH significantly. P and the total levels of 14 PAHs under study ( summation PAHs), that ranged from 490 to 3241 ng g(-1) dw (dry weight) with median value of 1521 ng g(-1) dw, were high for traffic areas, and low for residential or park areas, implying the significant contributions of PAHs in both gas and particle phases emitted by vehicles. However, PAH profiles in pine needles were not significantly altered by the washing, due to the low fractions (2-5%) of the 5- and 6-ring PAHs in summation PAHs. The high wind speed and frequently alternating wind directions in the Dalian spring could quicken the depuration processes of pine needle PAHs. Thus, the local meteorological conditions and source variations should be taken into account when using pine needles to implicate seasonal variations of atmospheric semi-volatile organic compounds. PMID:17968452

Yang, Ping; Chen, Jingwen; Wang, Zhen; Qiao, Xianliang; Cai, Xiyun; Tian, Fulin; Ge, Linke

2007-11-01

338

Prestress as an optimal biomechanical parameter for needle penetration.  

PubMed

Drug delivery requires precise intradermal and subcutaneous injections of formulations to clinically relevant penetration depths. However, penetration depth is confounded by skin deflection, which occurs prior to and during penetration as the skin surface deforms axially with the needle, and which varies profoundly due to differing intrinsic mechanical (e.g. viscoelastic) tissue properties, disease state, aging, and ethnicity. Herein, an ex vivo model was utilized to study factors that affect skin deflection and the efficacy of injection, including prestress applied at the tissue surface, needle gauge, velocity, and actuation depth. The application of prestress minimized skin deflection during needle penetration and allowed for needle actuation to the targeted penetration depths with minimum variability. The force required to achieve target penetration depths was found to increase with prestress and decrease with needle gauge. Our findings emphasize the need for prestress applied to the skin surface to minimize variation in skin properties and administer formulations for intradermal and subcutaneous treatments with maximum precision. PMID:22381739

Butz, Kent D; Griebel, Adam J; Novak, Tyler; Harris, Kevin; Kornokovich, Amy; Chiappetta, Michael F; Neu, Corey P

2012-04-30

339

Rheumatoid Arthritis–associated Interstitial Lung Disease: Radiologic Identification of Usual Interstitial Pneumonia Pattern  

PubMed Central

Purpose To determine the accuracy of computed tomography (CT) in identifying the histopathologic usual interstitial pneumonia (UIP) pattern in rheumatoid arthritis–associated interstitial lung disease (RA-ILD). Materials and Methods All patients were enrolled into institutional review board-approved longitudinal cohorts at their respective institution, and informed consent was obtained at the time of enrollment. Images of patients with surgical lung biopsy-proved RA-ILD (n = 69) were collected from three tertiary care centers. Two experienced thoracic radiologists independently reviewed the CT scans. The CT pattern was categorized as definite UIP, possible UIP, or inconsistent with UIP in accordance with published criteria. Findings of biopsies were reviewed by an experienced lung pathologist. The sensitivity and specificity of definite CT UIP pattern to histopathologic UIP pattern were determined. The agreement between radiologists was assessed by calculating a ? score. Results The histopathologic UIP pattern was present in 42 of 69 (61%) patients. Men were more likely than women to have a histopathologic UIP pattern (P = .02). Twenty patients (29%, 20 of 69) had a definite UIP pattern on CT scans. The specificity of CT UIP pattern was 96% (26 of 27; 95% confidence interval [CI]: 81%, 100%), with a negative predictive value of 53% (26 of 49). The sensitivity of CT UIP pattern was 45% (19 of 42; 95% CI: 30%, 61%), with a positive predictive value of 95% (19 of 20). The agreement between radiologists for definite UIP pattern versus not was 87% (? = 0.67, P < .0001). Conclusion Definite UIP pattern on a CT scan in RA-ILD is highly specific and moderately sensitive for histopathologic UIP pattern. CT can therefore help accurately identify the UIP pattern in RA-ILD. © RSNA, 2013 Online supplemental material is available for this article. PMID:24126367

Assayag, Deborah; Elicker, Brett M.; Urbania, Thomas H.; Colby, Thomas V.; Kang, Bo Hyoung; Ryu, Jay H.; King, Talmadge E.; Collard, Harold R.; Lee, Joyce S.

2014-01-01

340

NPIP: A skew line needle configuration optimization system for HDR brachytherapy  

SciTech Connect

Purpose: In this study, the authors introduce skew line needle configurations for high dose rate (HDR) brachytherapy and needle planning by integer program (NPIP), a computational method for generating these configurations. NPIP generates needle configurations that are specific to the anatomy of the patient, avoid critical structures near the penile bulb and other healthy structures, and avoid needle collisions inside the body. Methods: NPIP consisted of three major components: a method for generating a set of candidate needles, a needle selection component that chose a candidate needle subset to be inserted, and a dose planner for verifying that the final needle configuration could meet dose objectives. NPIP was used to compute needle configurations for prostate cancer data sets from patients previously treated at our clinic. NPIP took two user-parameters: a number of candidate needles, and needle coverage radius, {delta}. The candidate needle set consisted of 5000 needles, and a range of {delta} values was used to compute different needle configurations for each patient. Dose plans were computed for each needle configuration. The number of needles generated and dosimetry were analyzed and compared to the physician implant. Results: NPIP computed at least one needle configuration for every patient that met dose objectives, avoided healthy structures and needle collisions, and used as many or fewer needles than standard practice. These needle configurations corresponded to a narrow range of {delta} values, which could be used as default values if this system is used in practice. The average end-to-end runtime for this implementation of NPIP was 286 s, but there was a wide variation from case to case. Conclusions: The authors have shown that NPIP can automatically generate skew line needle configurations with the aforementioned properties, and that given the correct input parameters, NPIP can generate needle configurations which meet dose objectives and use as many or fewer needles than the current HDR brachytherapy workflow. Combined with robot assisted brachytherapy, this system has the potential to reduce side effects associated with treatment. A physical trial should be done to test the implant feasibility of NPIP needle configurations.

Siauw, Timmy; Cunha, Adam; Berenson, Dmitry; Atamtuerk, Alper; Hsu, I-Chow; Goldberg, Ken; Pouliot, Jean [Department of Civil and Environmental Engineering, University of California, Berkeley, 760 Davis Hall, Berkeley, California 94720-1710 (United States); Department of Radiation Oncology, University of California, San Francisco, Comprehensive Cancer Center, 1600 Divisadero Street, Suite H1031, San Francisco, California 94143-1708 (United States); Department of Electrical Engineering and Computer Science, University of California, Berkeley, 4th Floor Sutardja Dai Hall, Berkeley, California 94720-1764 (United States); Department of Industrial Engineering and Operations, University of California, Berkeley, 4141 Etcheverry Hall, Berkeley, California 94720-1777 (United States); Department of Radiation Oncology, University of California, San Francisco, Comprehensive Cancer Center, 1600 Divisadero Street, Suite H1031, San Francisco, California 94143-1708 (United States); Department of Industrial Engineering and Operations Research and Department of Electrical Engineering and Computer Science, University of California, Berkeley, 4141 Etcheverry Hall, Berkeley, California 94720-1777 (United States); Department of Radiation Oncology, University of California, San Francisco, Comprehensive Cancer Center, 1600 Divisadero Street, Suite H1031, San Francisco, California 94143-1708 (United States)

2012-07-15

341

Robotic Ultrasound and Needle Guidance for Prostate Cancer Management: Review of the Contemporary Literature  

PubMed Central

Purpose of review To present recent advances in needle guidance and robotic ultrasound technology which are used for prostate cancer diagnosis and management. Recent findings Prostate biopsy technology has remained relatively unchanged. Improved needle localization and precision would allow for better management of this common disease. Robotic ultrasound and needle guidance is one strategy to improve needle localization and diagnostic accuracy of PCa. This review focuses on recent advances in robotic ultrasound and needle guidance technologies and their potential impact on prostate cancer diagnosis and management Summary The use of robotic ultrasound and robotic-assisted needle guidance has the potential to improve prostate cancer diagnosis and management. PMID:24257431

Kaye, Deborah R.; Stoianovici, Dan; Han, Misop

2014-01-01

342

A case of psychosis induced self-insertion of intracranial hypodermic needles causing seizures.  

PubMed

Self-insertion of foreign bodies is a rare event. This report details a 56-year-old male who had self-inserted six hypodermic needles into his left frontal lobe 6 years previously. He subsequently presented with seizures and went on to have the needles surgically removed. This represents the first case of its type involving hypodermic needles. Given that intracranial needles are a rare finding, the management of such patients is complex. Two management issues in particular that require consideration are: (i) can the needles be left in situ and (ii) does removal of the needles reduce the risk of seizures in the long term? PMID:25600130

Chandran, Arjun S; Honeybul, Stephen

2015-01-01

343

[Value of Fine Needle Aspiration Cytology and Core Needle Biopsy in the Head and Neck Region.  

PubMed

Background: Fine-needle aspiration cytology (FNAC) and core-needle biopsy (CNB) represent 2 minimal invasive methods for further assessment of suspect lesions of the head and neck area. However, only limited data on the direct comparison of both methods has been published. The aim of this retrospective study was to evaluate the diagnostic value of FNAC and CNB and to compare their sensitivity and specificity. Material and methods: Between 2005 and 2012, CNB was performed in 86 patients and FNAC in 408 patients. 52 of 86 CNB-patients and 224 of 408 FNAC-patients underwent surgery afterwards and were included into the study (n=276). In order to compare the results of both methods the corresponding final histopathological finding from surgery was considered. Results: The sensitivity of the FNAC-group was higher (85%) compared to the CNB-group (80%), the specificity (87 vs. 94%) as well as the positive predictive value (64 vs. 97%) was lower. The negative predictive value (92 vs. 71%) and also the false negative value of the FNAC (5 vs. 13%) were superior to the results of the CNB-group. Concerning the false positive value the CNB-group showed better results (2 vs. 15%). Conclusion: Both methods are well suited to clarify the dignity of lesions in the head and neck region. In the current case series, FNAC seemed particularly suitable for diagnosis of hematologic diseases and the exclusion of malignancy in suspicious lymph nodes. The GNP has proven to be valid in the detection of tumor recurrences in irradiated or previously operated tissue, furthermore the definitive oncological treatment can be planed, based on the histopathological results obtained by GNP. PMID:25255122

Thierauf, J; Lindemann, J; Bommer, M; Veit, J A; Hoffmann, T K

2014-09-25

344

Desquamative interstitial pneumonia associated with chrysotile asbestos fibres.  

PubMed

The drywall construction trade has in the past been associated with exposure to airborne asbestos fibres. This paper reports a drywall construction worker with 32 years of dust exposure who developed dyspnoea and diminished diffusing capacity, and showed diffuse irregular opacities on chest radiography. He did not respond to treatment with corticosteroids. Open lung biopsy examination showed desquamative interstitial pneumonia. Only a single ferruginous body was seen on frozen section, but tissue examination by electron microscopy showed an extraordinary pulmonary burden of mineral dust with especially high concentrations of chrysotile asbestos fibres. This report emphasises the need to consider asbestos fibre as an agent in the aetiology of desquamative interstitial pneumonia. The coexistent slight interstitial fibrosis present in this case is also considered to have resulted from exposure to mineral dust, particularly ultramicroscopic asbestos fibres. PMID:1645584

Freed, J A; Miller, A; Gordon, R E; Fischbein, A; Kleinerman, J; Langer, A M

1991-05-01

345

Hermansky-Pudlak syndrome with nonspecific interstitial pneumonia.  

PubMed

We herein report a case of Hermansky-Pudlak syndrome (HPS) with nonspecific interstitial pneumonia (NSIP). A 58-year-old Japanese woman presented with oculocutaneous albinism and dyspnea on exertion. A high resolution computed tomography scan showed areas of reticular and ground glass opacity in the lungs, and a surgical lung biopsy revealed fibrotic NSIP. Foamy type 2 pneumocytes and the absence of dense granules in platelets were also observed, consistent with a diagnosis of HPS. Ultimately, a genetic analysis revealed a mutation in the HPS1 gene. The interstitial pneumonia progressed despite treatment with prednisolone, cyclosporine A and pirfenidone. In this report, we discuss the pathological lung features and treatment of HPS associated with interstitial pneumonia. PMID:24583434

Furuhashi, Kazuki; Enomoto, Noriyuki; Fujisawa, Tomoyuki; Hashimoto, Dai; Inui, Naoki; Nakamura, Yutaro; Suda, Takafumi

2014-01-01

346

Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease  

SciTech Connect

The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later.

Balestra, D.J.; Balestra, S.T.; Wasson, J.H.

1988-07-01

347

Desquamative interstitial pneumonia associated with chrysotile asbestos fibres.  

PubMed Central

The drywall construction trade has in the past been associated with exposure to airborne asbestos fibres. This paper reports a drywall construction worker with 32 years of dust exposure who developed dyspnoea and diminished diffusing capacity, and showed diffuse irregular opacities on chest radiography. He did not respond to treatment with corticosteroids. Open lung biopsy examination showed desquamative interstitial pneumonia. Only a single ferruginous body was seen on frozen section, but tissue examination by electron microscopy showed an extraordinary pulmonary burden of mineral dust with especially high concentrations of chrysotile asbestos fibres. This report emphasises the need to consider asbestos fibre as an agent in the aetiology of desquamative interstitial pneumonia. The coexistent slight interstitial fibrosis present in this case is also considered to have resulted from exposure to mineral dust, particularly ultramicroscopic asbestos fibres. Images PMID:1645584

Freed, J A; Miller, A; Gordon, R E; Fischbein, A; Kleinerman, J; Langer, A M

1991-01-01

348

Model-based needle control in prostate percutaneous procedures.  

PubMed

In percutaneous applications, needle insertion into soft tissue is considered as a challenging procedure, and hence, it has been the subject of many recent studies. This study considers a model-based dynamics equation to evaluate the needle movement through prostate soft tissue. The proposed model estimates the applied force to the needle using the tissue deformation data and finite element model of the tissue. To address the role of mechanical properties of the soft tissue, an inverse dynamics control method based on sliding mode approach is used to demonstrate system performance in the presence of uncertainties. Furthermore, to deal with inaccurate estimation of mechanical parameters of the soft tissue, an adaptive controller is developed. Moreover, through a sensitivity analysis, it is shown that the uncertainty in the tissue mechanical parameters affects the system performance. Our results indicate that the adaptive controller approach performs slightly better than inverse dynamics method at the expense of fine-tuning the additional gain parameter. PMID:23516956

Maghsoudi, Arash; Jahed, Mehran

2013-01-01

349

Skin blood perfusion and cellular response to insertion of insulin pen needles with different diameters.  

PubMed

Today most research on pen needle design revolves around pain perception statements through clinical trials, but these are both costly, timely, and require high sample sizes. The purpose of this study was to test if tissue damage, caused by different types of needles, can be assessed by evaluating skin blood perfusion response around needle insertion sites. Three common sized pen needles of 28G, 30G, and 32G as well as hooked 32G needles, were inserted into the neck skin of pigs and then removed. Laser Speckle Contrast Analysis was used to measure skin blood perfusion for 20 minutes after the insertions. Seven pigs were included in the study and a total of 118 randomized needle insertions were conducted. Histology was made of tissue samples inserted with 18G, 28G, and 32G needles, and stained to quantify red and white blood cell response. Based on area under curve, calculated for each individual blood perfusion recording and grouped according to needle type, skin blood perfusion response relates to needle diameter. The response was significantly higher after insertions with 28G and hooked 32G needles than with 30G (P < .05) and 32G (P < .01) needles. Histology results were not significant, but there was a trend of an increased response with increasing needle diameter. Skin blood perfusion response to pen needle insertions rank according to needle diameter, and the tissue response caused by hooked 32G needles corresponds to that of 28G needles. The relation between needle diameter and trauma when analyzing histology was also suggested. PMID:24876418

Præstmark, Kezia Ann; Jensen, Casper Bo; Stallknecht, Bente; Madsen, Nils Berg; Kildegaard, Jonas

2014-07-01

350

MUC5B Promoter Polymorphism and Interstitial Lung Abnormalities  

PubMed Central

BACKGROUND A common promoter polymorphism (rs35705950) in MUC5B, the gene encoding mucin 5B, is associated with idiopathic pulmonary fibrosis. It is not known whether this polymorphism is associated with interstitial lung disease in the general population. METHODS We performed a blinded assessment of interstitial lung abnormalities detected in 2633 participants in the Framingham Heart Study by means of volumetric chest computed tomography (CT). We evaluated the relationship between the abnormalities and the genotype at the rs35705950 locus. RESULTS Of the 2633 chest CT scans that were evaluated, interstitial lung abnormalities were present in 177 (7%). Participants with such abnormalities were more likely to have shortness of breath and chronic cough and reduced measures of total lung and diffusion capacity, as compared with participants without such abnormalities. After adjustment for covariates, for each copy of the minor rs35705950 allele, the odds of interstitial lung abnormalities were 2.8 times greater (95% confidence interval [CI], 2.0 to 3.9; P<0.001), and the odds of definite CT evidence of pulmonary fibrosis were 6.3 times greater (95% CI, 3.1 to 12.7; P<0.001). Although the evidence of an association between the MUC5B genotype and interstitial lung abnormalities was greater among participants who were older than 50 years of age, a history of cigarette smoking did not appear to influence the association. CONCLUSIONS The MUC5B promoter polymorphism was found to be associated with interstitial lung disease in the general population. Although this association was more apparent in older persons, it did not appear to be influenced by cigarette smoking. (Funded by the National Institutes of Health and others; ClinicalTrials.gov number, NCT00005121.) PMID:23692170

Hunninghake, Gary M.; Hatabu, Hiroto; Okajima, Yuka; Gao, Wei; Dupuis, Josée; Latourelle, Jeanne C.; Nishino, Mizuki; Araki, Tetsuro; Zazueta, Oscar E.; Kurugol, Sila; Ross, James C.; Estépar, Raúl San José; Murphy, Elissa; Steele, Mark P.; Loyd, James E.; Schwarz, Marvin I.; Fingerlin, Tasha E.; Rosas, Ivan O.; Washko, George R.; O’Connor, George T.; Schwartz, David A.

2013-01-01

351

A model to predict deflection of bevel-tipped active needle advancing in soft tissue.  

PubMed

Active needles are recently being developed to improve steerability and placement accuracy for various medical applications. These active needles can bend during insertion by actuators attached to their bodies. The bending of active needles enables them to be steered away from the critical organs on the way to target and accurately reach target locations previously unachievable with conventional rigid needles. These active needles combined with an asymmetric bevel-tip can further improve their steerability. To optimize the design and to develop accurate path planning and control algorithms, there is a need to develop a tissue-needle interaction model. This work presents an energy-based model that predicts needle deflection of active bevel-tipped needles when inserted into the tissue. This current model was based on an existing energy-based model for bevel-tipped needles, to which work of actuation was included in calculating the system energy. The developed model was validated with needle insertion experiments with a phantom material. The model predicts needle deflection reasonably for higher diameter needles (11.6% error), whereas largest error was observed for the smallest needle diameter (24.7% error). PMID:24296105

Datla, Naresh V; Konh, Bardia; Honarvar, Mohammad; Podder, Tarun K; Dicker, Adam P; Yu, Yan; Hutapea, Parsaoran

2014-03-01

352

Highly coherent electron beam from a laser-triggered tungsten needle tip  

E-print Network

We report on a quantitative measurement of the spatial coherence of electrons emitted from a sharp metal needle tip. We investigate the coherence in photoemission using near-ultraviolet laser triggering with a photon energy of 3.1 eV and compare it to DC-field emission. A carbon-nanotube is brought in close proximity to the emitter tip to act as an electrostatic biprism. From the resulting electron matter wave interference fringes we deduce an upper limit of the effective source radius both in laser-triggered and DC-field emission mode, which quantifies the spatial coherence of the emitted electron beam. We obtain $(0.80\\pm 0.05)\\,$nm in laser-triggered and $(0.55\\pm 0.02)\\,$nm in DC-field emission mode, revealing that the outstanding coherence properties of electron beams from needle tip field emitters are largely maintained in laser-induced emission. In addition, the relative coherence width of 0.36 of the photoemitted electron beam is the largest observed so far. The preservation of electronic coherence du...

Ehberger, Dominik; Eisele, Max; Krüger, Michael; Noe, Jonathan; Högele, Alexander; Hommelhoff, Peter

2014-01-01

353

Effect of cadmium in sediments on colonization by benthic marine organisms: Role of interstitial cadmium and acid volatile sulfide in bioavailability  

SciTech Connect

The role of interstitial cadmium and acid volatile sulfide (AVS) in controlling the bioavailability of sediment-associated metal was examined using the chronic saltwater benthic colonization test. Sediments were spiked with cadmium to achieve simultaneously extracted metal (SEM)/AVS molar ratios of 0. 0 (control), 0.1, 0.8 and 3.0 in this 118-day test. Oxidation of AVS in the surficial 2.4 cm within two to four weeks resulted in sulfide profiles similar to those occurring naturally in local sediments. In the nominal 0.1 SEM/AVS treatment, measured SEM was always less than AVS. Interstitial cadmium concentrations (< 3--10 {micro}g/L) were below those likely to cause biological effects. No significant biological effects were detected. In the nominal 0.8 SEM/AVS treatment, measured SEM commonly exceeded AVS in the surficial 2.4 cm of sediment. Interstitial cadmium concentrations (24--157 {micro}g/L) were likely of toxicological significance to sensitive species. Shifts were observed in presence/absence of species, and there were fewer macrobenthic polychaetes (Mediomastus ambiseta, Strebloapio benedicti and Podarke obscura) and unidentified meiofaunal nematodes. In the nominal 3.0 SEM/AVS treatment, concentrations of SEM were always greater than AVS throughout the sediment column. Interstitial cadmium ranged from 28,000 to 174,000 {micro}g/L. In addition to the effects above, these sediments were colonized by fewer macrobenthic species, polychaete species and harpacticoids; had lower densities of diatoms; lacked bivalve molluscs and exhibited other impacts. The observed biological responses were consistent with measured SEM/AVS ratios in surficial sediments and interstitial water cadmium concentrations, further supporting their utility in predicting metals bioavailability.

Hansen, D.; Berry, W.; Benyi, S. [Environmental Protection Agency, Narragansett, RI (United States); Mahony, J. [Manhattan College, Riverdale, NY (United States); Corbin, J. [TNRCC, Austin, TX (United States); Pratt, S.; Able, M. [Univ. of Rhode Island, Narragansett, RI (United States)

1995-12-31

354

[HRCT patterns of the most important interstitial lung diseases].  

PubMed

Interstitial lung diseases are a mixed group of diffuse parenchymal lung diseases which can have an acute or chronic course. Idiopathic diseases and diseases with an underlying cause (e.g. collagen vascular diseases) share the same patterns. Thin section computed tomography (CT) plays a central role in the diagnostic work-up. The article describes the most important interstitial lung diseases following a four pattern approach with a predominant nodular or reticular pattern or a pattern with increased or decreased lung density. PMID:25503518

Schaefer-Prokop, C

2014-12-01

355

Ectrodactyly and proximal/intermediate interstitial deletion 7q  

SciTech Connect

We report on an individual with severe mental retardation, seizures, microcephaly, unusual face, scoliosis, and cleft feet and cleft right hand. The chromosomal study showed a proximal interstitial deletion 7q (q11.23q22). From our review of the literature, 11 patients have been reported with ectrodactyly (split hand/split foot malformation) and proximal/intermediate interstitial deletions or rearrangements of 7q. The critical segment for ectrodactyly seems to be located between 7q21.2 and 7q22.1. This malformation is present in 41% of the patients whose deletion involves the critical segment. 37 refs., 3 figs., 1 tab.

McElveen, C.; Carvajal, M.V.; Moscatello, D. [Louisiana State Univ. Medical Center, New Orleans, LA (United States)] [and others

1995-03-13

356

Acute interstitial nephritis following kudzu root juice ingestion.  

PubMed

Recently, the use of herbal remedies and complementary and alternative medicine has increased globally. Kudzu root (Pueraria lobata) is a plant commonly used in traditional medicine to promote health. A middle-aged woman consumed kudzu root juice to promote health and well-being for 10 days. Subsequently, she developed anorexia, epigastric discomfort and azotemia. These symptoms improved rapidly within several days after discontinuation of the suspected offending agent and conservative treatment. Acute interstitial nephritis was diagnosed by renal biopsy. To our knowledge, this is the first case report describing acute interstitial nephritis following the ingestion of kudzu root juice. PMID:24060140

Jung, Jae Myun; Kwon, Soon Hyo; Noh, Hyunjin; Han, Dong Cheol; Jeon, Jin Seok; Jin, So Young

2013-10-01

357

Dose and volume specification for reporting interstitial therapy  

SciTech Connect

The ICRU has previously published reports dealing with Dose Specification for Reporting External Beam Therapy with Photons and Electrons (ICRU Report 29, ICRU, 1978), Dose Specification for Reporting External Beam Therapy (ICRU Report 50, ICRU, 1993) and Dose and Volume Specification for Reporting Intracavitary Therapy in Gynecology (ICRU Report 38, ICRU, 1985). The present report addresses the problem of absorbed dose specification for report interstitial therapy. Although specific to interstitial therapy, many of the concepts developed in this report are also applicable to certain other kinds of brachytherapy applications. In particular, special cases of intraluminal brachytherapy and plesio-brachytherapy via surface molds employing x or gamma emitters are addressed in this report.

NONE

1997-12-30

358

A Case of Venlafaxine-Induced Interstitial Lung Disease  

PubMed Central

A patient treated with venlafaxine for major depression developed an interstitial lung disease (ILD) with the characteristic clinical, radiological and pathological features of chronic hypersensitivity pneumonitis. A high resolution computed tomography scan demonstrated ground glass opacity, mosaic perfusion with air-trapping and traction bronchiectasis in both lungs. The pathological findings were consistent with a nonspecific interstitial pneumonia pattern. Clinical and radiological improvements were noted after the discontinuation of venlafaxine and the administration of a corticosteroid. This report provides further evidence that the anti-depressant venlafaxine can cause ILD. PMID:25237379

Oh, Serim; Kim, Hyera; Kim, Minjung; Choi, Sun Ha; Seo, Hyewon; Park, Tae-In

2014-01-01

359

Needle biopsy diagnosis of solitary amyloid nodule of the lung.  

PubMed

Solitary amyloid nodule of the lung is an unusual form of localized amyloidosis which is rarely diagnosed prior to surgical resection. This report describes a case of solitary amyloid nodule of the lung which was suggested prospectively on the initial needle biopsy. The histologic and cytologic features of the lesion appear to be characteristic and may allow a definitive diagnosis to be made on needle biopsy. The differential diagnosis from necrotic tumor and medullary carcinoma is described. The subsequently resected nodule was studied by both electron microscopy and immunofluorescent techniques. Immunofluorescent staining failed to confirm an origin of the lesion from a single clone of plasma cells. PMID:6931466

Tomashefski, J F; Cramer, S F; Abramowsky, C; Cohen, A M; Horak, G

1980-01-01

360

Application of a dislocation based model for Interstitial Free (IF) steels to typical stamping simulations  

NASA Astrophysics Data System (ADS)

With a view to environmental, economic and safety concerns, car manufacturers need to design lighter and safer vehicles in ever shorter development times. In recent years, High Strength Steels (HSS) like Interstitial Free (IF) steels which have higher ratios of yield strength to elastic modulus, are increasingly used for sheet metal parts in automotive industry to meet the demands. Moreover, the application of sheet metal forming simulations has proven to be beneficial to reduce tool costs in the design stage and to optimize current processes. The Finite Element Method (FEM) is quite successful to simulate metal forming processes but accuracy largely depends on the quality of the material properties provided as input to the material model. Common phenomenological models roughly consist in the fitting of functions on experimental results and do not provide any predictive character for different metals from the same grade. Therefore, the use of accurate plasticity models based on physics would increase predictive capability, reduce parameter identification cost and allow for robust and time-effective finite element simulations. For this purpose, a 3D physically based model at large strain with dislocation density evolution approach was presented in IDDRG2009 by the authors [1]. This model allows the description of work-hardening's behavior for different loading paths (i.e. uni-axial tensile, simple shear and Bauschinger tests) taking into account several data from microstructure (i.e. grain size, texture, etc…). The originality of this model consists in the introduction of microstructure data in a classical phenomenological model in order to achieve work-hardening's predictive character for different metals from the same grade. Indeed, thanks to a microstructure parameter set for an Interstitial Free steel, it is possible to describe work-hardening behavior for different loading paths of other IF steels by only changing the mean grain size and the chemical composition. During sheet metal forming processes local material points may experience multi-axial and multi-path loadings. Before simulating actual industrial parts, automotive manufacturers use validation tools—e.g. the Cross-Die stamping test. Such typical stamping tests enable the evaluation of a complex distribution of strains. The work described is an implementation [2] of a 3D dislocation based model in ABAQUS/Explicit and its validation on a Finite Element (FE) Cross-Die model. In order to assess the performance and relevance of the 3D dislocation based model in the simulation of industrial forming applications, the results of thinning profiles predicted along several directions and the strain distribution were obtained and compared with experimental results for IF steels with grain sizes varying in the 8-22 ?m value range.

Carvalho Resende, T.; Balan, T.; Abed-Meraim, F.; Bouvier, S.; Sablin, S.-S.

2010-06-01

361

Experimental analysis of stove top designs for pine needle combustion in a semi-gasifier burner  

E-print Network

The motivation behind this project was to develop a better understanding of the role that the stove top plays in a stove where pine needles are the main fuel source. Pine needles have distinct characteristics in their ...

Roqué, Alyssa J

2011-01-01

362

Characteristics of pine needle combustion in a semi-gasifier burner  

E-print Network

The motivation behind this report was to develop a stronger understanding of pine needle combustion behavior in a semi-gasifier, in order to ultimately design an effective pine needle cook stove for people in the developing ...

Fang, Liane Jessica

2011-01-01

363

[Incidence of a needle stick injury occurring in a needleless intravenous system].  

PubMed

A needle stick injury occurred with a needleless intravenous system. When a nurse picked up a disposable glove left on the floor of an operating room to discard it, there was an intravenous needle left under the glove and caused a needle stick injury to the nurse. Although the needle was designed as a needleless intravenous system, we found after a close observation that there is a potential hazard for a needle stick injury regarding the needle. The incidence happened due to the negligence of standard precaution by another health care provider (a doctor); leaving the contaminated needle on the floor. Unfortunately, the disposable glove fell on the needle for some reason and concealed it. Should the doctor follow the standard precaution properly, i.e. discard it in a puncture-resistant sharps container immediately, this incidence might not have happened. Any safety device may not prevent incidence 100%, we have to always heed and follow a standard precaution. PMID:18516895

Mizuta, Nanako; Kurahashi, Kiyoyasu

2008-05-01

364

Planning fireworks trajectories for steerable medical needles to reduce patient trauma  

Microsoft Academic Search

Accurate needle insertion in 3D environment is always a grand challenge. When multiple targets are located in the tissue, a procedure of inserting multiple needles from a single small region on the patient's skin, so called \\

Jijie Xu; Vincent Duindam; Ron Alterovitz; Jean Pouliot; J. Adam M. Cunha; I-chow Hsu; Kenneth Y. Goldberg

2009-01-01

365

High-resolution electrohydrodynamic printing of silver nanoparticle ink via commercial hypodermic needles  

NASA Astrophysics Data System (ADS)

The effect of the needle shape on electrohydrodynamic (EHD) printing was investigated by comparing flat outlet needles and hypodermic needles. Line fabrication was performed to confirm the tendency of jetting stability and the printed line width with various driving voltage and stage speed by using Ag nanoparticle ink as a jetting solution on a hydrophobic surface. We verified that the hypodermic needle greatly improves the resolution in EHD printing. The ink slips down the inner wall of the hypodermic needle, and a very small meniscus is generated at the tip of the needle. Due to this phenomenon, high-resolution printing can be accomplished. The narrowest line that was fabricated using a hypodermic needle has a line width of 0.7 ?m, and it is smaller than 1% of the needle inner diameter.

Kim, Yeongjun; Jang, Shin; Oh, Je Hoon

2015-01-01

366

Fluid flow through dural puncture sites. An in vitro comparison of needle point types.  

PubMed

Leakage of artificial cerebrospinal fluid through human dura was measured in vitro after puncture by spinal needles. Fluid loss tailed off in all cases and ceased within 5 minutes in 10% of punctures made with a 22-gauge needle, 28% made with a 26-gauge and 65% made with a 29-gauge needle (p less than 0.05). The fluid loss was not reduced by alignment of the level of the needle parallel to the longitudinal direction of the fibres. Whitacre point needles of 22 gauge produced lower fluid loss than a 22-gauge Quincke point needle inserted across the fibres (p less than 0.05). Leakage rate was related to needle size, but not related to the alignment of a Quincke point. Little or no leakage occurred with 29-gauge needles. PMID:2742103

Cruickshank, R H; Hopkinson, J M

1989-05-01

367

Combination of transurethral and interstitial ultrasound applicators for high-temperature prostate thermal therapy.  

PubMed

The purpose of this study was to determine the feasibility of using a transurethral ultrasound applicator in combination with implantable ultrasound applicators for inducing thermal coagulation and necrosis of localized cancer lesions or benign disease within the prostate gland. The potential to treat target zones in the anterior and lateral portions of the prostate with the angularly directive transurethral applicator, while simultaneously treating regions of extracapsular extension and zones in the posterior prostate with the directive implantable applicators in combination with a rectal cooling bolus, is evaluated. Biothermal computer simulations, acoustic characterizations, and in vivo thermal dosimetry experiments with canine prostates were used to evaluate the performance of each applicator type and combinations thereof. Simulations have demonstrated that transurethral applicators with 180-270 degrees acoustic active zones can direct therapeutic heating patterns to the anterior and lateral prostate, implantable needles can isolate heating to the posterior gland while avoiding rectal tissue, and that the combination of applicators can be used to produce conformal heating to the whole gland. Single implantable applicators (1.8 mm OD x 10 mm long, approximately 180 degrees active sector, approximately 7 MHz, direct-coupled type) produced directional thermal lesions within in vivo prostate, with temperatures >50 degrees C extending more than 10 mm radially after 10-15 min. Combination of interstitial applicators (1-2) and a transurethral applicator (3-2.5 mm OD x 6 mm long, approximately 180 degrees active sector, 6.8 MHz, 6 mm OD delivery catheter) produced conforming temperature distributions (48-85 degrees C) and zones of acute thermal damage within 15 min. The preliminary results of this investigation demonstrate that implantable directional ultrasound applicators, in combination with a transurethral ultrasound applicator, have the potential to provide thermal coagulation and necrosis of small or large regions within the prostate gland, while sparing thermally sensitive rectal tissue. PMID:11001573

Diederich, C J; Nau, W H; Burdette, E C; Bustany, I S; Deardorff, D L; Stauffer, P R

2000-01-01

368

Fabricating needle arrays with a gray-scale x-ray mask  

Microsoft Academic Search

A gray-scale mask for x-ray lithography, made using microelectrome- chanical systems technology, offers a new approach to manufacturing needle arrays. Microscopic needles long enough to penetrate skin but short enough to avoid touching nerves provide a method for painless injections. Research into a process for mass-producing micro- needle arrays for drug delivery is leaping forward as the needles become a

Harutaka Mekaru

2008-01-01

369

Complex intermetallic phase in multicrystalline silicon doped with transition metals Matthias Heuer,1 Tonio Buonassisi,1 Matthew A. Marcus,2 Andrei A. Istratov,1 Matthew D. Pickett,1 Tomohiro Shibata,3  

E-print Network

is that transition metals can be found in silicon as either interstitial or substitutional species, point defect complexes e.g., interstitial-substitutional pairs , or single-metal silicide precipitates, such as Cu3Si; revised manuscript received 12 May 2006; published 8 June 2006 We report the observation of an alloy phase

370

Concentration of Antibacterial Agents in Interstitial Tissue Fluid  

Microsoft Academic Search

The concentration of antibacterial agents in the interstitial tissue fluid has been studied in an experimental model using implanted perforated Silastic capsules (tissue cages). Tissue fluid concentrations were always lower than the initial peak concentration in the serum, but for those drugs that were more slowly excreted the tissue fluid was similar to the serum concentration after six hours. In

G. D. Chisholm; Pamela M. Waterworth; J. S. Calnan; L. P. Garrod

1973-01-01

371

Connective Tissue Disease-associated Interstitial Lung Disease: A review  

PubMed Central

Interstitial lung disease (ILD) is commonly encountered in patients with connective tissue diseases (CTD). Besides the lung parenchyma, the airways, pulmonary vasculature and structures of the chest wall may all be involved, depending on the type of CTD. As a result of this so-called multi-compartment involvement, airflow limitation, pulmonary hypertension, vasculitis and extrapulmonary restriction can occur alongside fibro-inflammatory parenchymal abnormalities in CTD. Rheumatoid arthritis (RA), systemic sclerosis (SSc), poly-/dermatomyositis (PM/DM), Sjögren’s syndrome (SjS), systemic lupus erythematosus (SLE), and undifferentiated (UCTD) as well as mixed connective tissue disease (MCTD) can all be associated with the development of ILD. Non-specific interstitial pneumonia (NSIP) is the most commonly observed histopathological pattern in CTD-ILD, but other patterns including usual interstitial pneumonia (UIP), organizing pneumonia (OP), diffuse alveolar damage (DAD) and lymphocytic interstitial pneumonia (LIP) may occur. Although the majority of patients with CTD-ILD experience stable or slowly advancing ILD, a small yet significant group exhibits a more severe and progressive course. Randomized placebo-controlled trials evaluating the efficacy of immunomodulatory treatments have been conducted only in SSc-associated ILD. However, clinical experience suggests that a handful of immunosuppressive medications are potentially effective in a sizeable portion of patients with ILD caused by other CTDs. In this manuscript, we review the clinical characteristics and management of the most common CTD-ILDs. PMID:23125954

Gutsche, Markus; Rosen, Glenn D.; Swigris, Jeffrey J.

2012-01-01

372

Rheumatoid interstitial lung disease presenting as cor pulmonale  

PubMed Central

Rheumatiod arthritis (RA) is a multisystem connective tissue disorder. The predominant presentation is polyarticular, symmetric peripheral arthritis with relative sparing of axial skeleton. Inflammatory synovitis is the pathologic hallmark. Extra-articular manifestations of RA can involve several other organ systems and amongst them pulmonary manifestations occur commonly. We report a case of rheumatoid interstitial lung disease presenting as cor pulmonale. PMID:21139729

Acharya, Sourya; Mahajan, S. N.; Shukla, Samarth; Diwan, S. K.; Banode, Pankaj; Kothari, Nirmesh

2010-01-01

373

Tumor interstitial fluid - a treasure trove of cancer biomarkers.  

PubMed

Tumor interstitial fluid (TIF) is a proximal fluid that, in addition to the set of blood soluble phase-borne proteins, holds a subset of aberrantly externalized components, mainly proteins, released by tumor cells and tumor microenvironment through various mechanisms, which include classical secretion, non-classical secretion, secretion via exosomes and membrane protein shedding. Consequently, the interstitial aqueous phase of solid tumors is a highly promising resource for the discovery of molecules associated with pathological changes in tissues. Firstly, it allows one to delve deeper into the regulatory mechanisms and functions of secretion-related processes in tumor development. Secondly, the anomalous secretion of molecules that is innate to tumors and the tumor microenvironment, being associated with cancer progression, offers a valuable source for biomarker discovery and possible targets for therapeutic intervention. Here we provide an overview of the features of tumor-associated interstitial fluids, based on recent and updated information obtained mainly from our studies of breast cancer. Data from the study of interstitial fluids recovered from several other types of cancer are also discussed. This article is a part of a Special Issue entitled: The Updated Secretome. PMID:23416532

Gromov, Pavel; Gromova, Irina; Olsen, Charlotta J; Timmermans-Wielenga, Vera; Talman, Mai-Lis; Serizawa, Reza R; Moreira, José M A

2013-11-01

374

Membranous Nephropathy and Granulomatous Interstitial Nephritis in Sarcoidosis  

Microsoft Academic Search

A 56-year-old woman developed nephrotic syndrome in association with pulmonary sarcoidosis. Renal biopsy revealed both granulomatous interstitial nephritis and membranous nephropathy. Treatment with steroids resulted in a decrease in proteinuria and there was no deterioration in renal function over a subsequent period of 10 months. This case provides further evidence that secondary membranous nephropathy associated with sarcoidosis should be treated

Izhar H. Khan; John G. Simpson; Graeme R. D. Catto; Alison M. MacLeod

1994-01-01

375

Histopathologic Variability in Usual and Nonspecific Interstitial Pneumonias  

Microsoft Academic Search

Findings of surgical lung biopsy (SLB) are important in categoriz- ing patients with idiopathic interstitial pneumonia (IIP). We inves- tigated whether histologic variability would be evident in SLB specimens from multiple lobes in patients with IIP. SLBs from 168 patients, 109 of whom had multiple lobes biopsied, were reviewed by three pathologists. A diagnosis was assigned to each lobe. A

KEVIN R. FLAHERTY; WILLIAM D. TRAVIS; THOMAS V. COLBY; GALEN B. TOEWS; ELLA A. KAZEROONI; BARRY H. GROSS; ARVIND JAIN; ROBERT L. STRAWDERMAN; ANDREW FLINT; JOSEPH P. LYNCH; FERNANDO J. MARTINEZ

376

Rotational and vibrational dynamics of interstitial molecular hydrogen T. Yildirim  

E-print Network

Rotational and vibrational dynamics of interstitial molecular hydrogen T. Yildirim National. INTRODUCTION The study of rotational and vibrational dynamics of guest molecules i.e., CO, O2 , H2, etc develop a detailed analysis of coupled rotational and vibrational dynamics of a molecular hydrogen

Yildirim, Taner

377

Well-point sampling of reef interstitial water  

Microsoft Academic Search

A technique is described for collecting reef interstitial water using manually-driven well points. This method does not require the use of hydraulic drills, and eliminates the problems associated with the casing of boreholes. The technique allows collection of samples from discrete depths within reef frameworks, and produces samples unaffected by atmospheric or surface seawater contamination. Data from Checker Reef, Oahu,

Francis J. Sansone; Christine C. Andrews; Robert W. Buddemeier; Gordon W. Tribble

1988-01-01

378

Radiology of diffuse interstitial pulmonary disease in children  

Microsoft Academic Search

Diffuse interstitial lung disease (DILD) represents a heterogeneous group of disorders characterised by restrictive lung function and impaired gas exchange. As these diseases occur on a background of the developing lungs and immune system, the clinical presentation and disease progression is modified by comparison with their adult equivalents; thus, often differs markedly in presentation, clinical features and progress from ILD

Catherine Owens

2004-01-01

379

Phase estimation for a phased array therapeutic interstitial ultrasound probe  

PubMed Central

This paper deals about high intensity ultrasound interstitial therapy simulation. The simulated phased array ultrasound probe allows a dynamic electronic focusing of the therapeutic beam. In order to maximize the power deposit at the focal point we propose a method which allows to optimally defining the phase shift of the electrical control signal for each individual element. PMID:23365931

Yang, Zhenya; Dillenseger, Jean-Louis

2012-01-01

380

An interstitial fluid transdermal extraction, collection and measurement system  

Microsoft Academic Search

We present a new microfluidic system for transdermal interstitial fluid (ISF) extraction, collection, and volumetric measurement towards the application of noninvasive, continuous, and real-time glucose monitoring. This device consists of a Venturi Tube for vacuum generation, chambers for the introduction of ISF and normal saline solution, pneumatic valves for fluid control, and flow sensors for ISF and normal saline solution

Haixia Yu; Dachao Li; Kexin Xu; Robert C. Roberts; Norman C. Tien

2011-01-01

381

An integrated microfluidic system for interstitial fluid transdermal extraction  

Microsoft Academic Search

We present a new microfluidic system for transdermal interstitial fluid (ISF) extraction, collection, and volumetric measurement towards the application of continuous glucose monitoring. This device consists of a venturi tube, a volume sensor, pneumatic valves, and microchannels. Under the management of pneumatic valves, demonstration of the defined volume normal saline injection, ISF extraction, collection and volumetric measurement functions of the

H. X. Yu; D. C. Li; R. C. Roberts; W. S. Liang; K. X. Xu; N. C. Tien

2011-01-01

382

Iodine 125 interstitial irradiation for localized prostate cancer.  

PubMed Central

We present the technique, complications, and 5-year results of transperineal percutaneous template permanent interstitial iodine 125 endocurietherapy of localized prostate cancer in 85 treated patients. The 5-year outcome appears similar to that of external beam radiation therapy or radical surgery, but the iatrogenic mortality, morbidity, treatment time, and hospitalization are significantly reduced. Images Figure 1 Figure 2 Figure 3 PMID:2319613

Kumar, P. P.; Good, R. R.; Bartone, F. F.

1990-01-01

383

Connective Tissue Disease-associated Interstitial Lung Disease: A review.  

PubMed

Interstitial lung disease (ILD) is commonly encountered in patients with connective tissue diseases (CTD). Besides the lung parenchyma, the airways, pulmonary vasculature and structures of the chest wall may all be involved, depending on the type of CTD. As a result of this so-called multi-compartment involvement, airflow limitation, pulmonary hypertension, vasculitis and extrapulmonary restriction can occur alongside fibro-inflammatory parenchymal abnormalities in CTD. Rheumatoid arthritis (RA), systemic sclerosis (SSc), poly-/dermatomyositis (PM/DM), Sjögren's syndrome (SjS), systemic lupus erythematosus (SLE), and undifferentiated (UCTD) as well as mixed connective tissue disease (MCTD) can all be associated with the development of ILD. Non-specific interstitial pneumonia (NSIP) is the most commonly observed histopathological pattern in CTD-ILD, but other patterns including usual interstitial pneumonia (UIP), organizing pneumonia (OP), diffuse alveolar damage (DAD) and lymphocytic interstitial pneumonia (LIP) may occur. Although the majority of patients with CTD-ILD experience stable or slowly advancing ILD, a small yet significant group exhibits a more severe and progressive course. Randomized placebo-controlled trials evaluating the efficacy of immunomodulatory treatments have been conducted only in SSc-associated ILD. However, clinical experience suggests that a handful of immunosuppressive medications are potentially effective in a sizeable portion of patients with ILD caused by other CTDs. In this manuscript, we review the clinical characteristics and management of the most common CTD-ILDs. PMID:23125954

Gutsche, Markus; Rosen, Glenn D; Swigris, Jeffrey J

2012-09-21

384

Complication of Clorpactin WCS90 therapy for interstitial cystitis.  

PubMed

A case of ureteral fibrosis complicating Clorpactin WCS90 treatment for interstitial cystitis in a patient with vesicoureteral reflux is presented. The results of a laboratory experiment designed to study the effects of Clorpactin WCS90 on refluxing ureters are discussed. PMID:219578

Messing, E M; Freiha, F S

1979-04-01

385

Effects of insertion speed and trocar stiffness on the accuracy of needle position for brachytherapy  

SciTech Connect

Purpose: In prostate brachytherapy, accurate positioning of the needle tip to place radioactive seeds at its target site is critical for successful radiation treatment. During the procedure, needle deflection leads to seed misplacement and suboptimal radiation dose to cancerous cells. In practice, radiation oncologists commonly use high-speed hand needle insertion to minimize displacement of the prostate as well as the needle deflection. Effects of speed during needle insertion and stiffness of trocar (a solid rod inside the hollow cannula) on needle deflection are studied. Methods: Needle insertion experiments into phantom were performed using a 2{sup 2} factorial design (2 parameters at 2 levels), with each condition having replicates. Analysis of the deflection data included calculating the average, standard deviation, and analysis of variance (ANOVA) to find significant single and two-way interaction factors. Results: The stiffer tungsten carbide trocar is effective in reducing the average and standard deviation of needle deflection. The fast insertion speed together with the stiffer trocar generated the smallest average and standard deviation for needle deflection for almost all cases. Conclusions: The combination of stiff tungsten carbide trocar and fast needle insertion speed are important to decreasing needle deflection. The knowledge gained from this study can be used to improve the accuracy of needle insertion during brachytherapy procedures.

McGill, Carl S.; Schwartz, Jonathon A.; Moore, Jason Z.; McLaughlin, Patrick W.; Shih, Albert J. [Biomedical Engineering Department, University of Michigan, Ann Arbor, Michigan 48109 (United States); Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, State College, Pennsylvania 16802 (United States); Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109 (United States); Biomedical Engineering Department, University of Michigan, Ann Arbor, Michigan 48109 and Mechanical Engineering Department, University of Michigan, Ann Arbor, Michigan 48109 (United States)

2012-04-15

386

Needle core length in sextant biopsy influences prostate cancer detection rate  

Microsoft Academic Search

Objectives. Prostate cancer detection in biopsies increases with the number of sites and total tissue sampled. Its dependence on needle core fragment length is uncertain.Methods. We surveyed two consecutive series of sextant needle biopsies from two practices in 1998 to 2000: 251 patients from Pennsylvania (group P) and 1596 from Virginia (group V). We tabulated the gross needle core lengths

Kenneth A Iczkowski; George Casella; R. John Seppala; Galin L Jones; Barbara A Mishler; Junqi Qian; David G Bostwick

2002-01-01

387

Biomechanics-Based Curvature Estimation for Ultrasound-guided Flexible Needle Steering in Biological Tissues.  

PubMed

Needle-based procedures are commonly performed during minimally invasive surgery for treatment and diagnosis. Accurate needle tip placement is important for the success of the procedures. Misplacement of the needle tip might cause unsuccessful treatment or misdiagnosis. Robot-assisted needle insertion systems have been developed in order to steer flexible bevel-tipped needles. However, current systems depend on the information of maximum needle curvature, which is estimated by performing prior insertions. This work presents a new three-dimensional flexible needle steering system which integrates an optimal steering control, ultrasound-based needle tracking system, needle deflection model, online needle curvature estimation and offline curvature estimation based on biomechanics properties. The online and the offline curvature estimations are used to update the steering control in real time. The system is evaluated by experiments in gelatin phantoms and biological tissues (chicken breast tissues). The average targeting error in gelatin phantoms is 0.42 ± 0.17 mm, and in biological tissues is 1.63 ± 0.29 mm. The system is able to accurately steer a flexible needle in multi-layer phantoms and biological tissues without performing prior insertions to estimate the maximum needle curvature. PMID:25465619

Moreira, Pedro; Misra, Sarthak

2014-12-01

388

Development and seasonal variations of Lophodermium populations on Pinus thunbergii needle litter  

Microsoft Academic Search

A quantitative method was developed to describe Lophodermium (Rhytismataceae, Ascomycetes) populations on Pinus thunbergii needle litter, and seasonal patterns of population variation were examined based on this method. We focused on the formation\\u000a of black zone lines across needles and the production of Lophodermium ascocarps on needle portions delimitated by zone lines. The study was carried out at a soil

Dai Hirose; Takashi Osono

2006-01-01

389

Transvaginal ovum pick-up (OPU) in the cow: A new disposable needle guidance system  

Microsoft Academic Search

A study was conducted to modify the routinely used ovum pick up (OPU) devices to permit use of disposable needles and to simplify the technique and to make it more economical and practical to use. Long nondisposable needles are commonly used in transvaginal OPU despite several disadvantages. A new OPU device was developed using 19-g disposable needles to eliminate these

P. E. J. Bols; J. M. M. Vandenheede; A. Van Soom; A. de Kruif

1995-01-01

390

Interactions of ozone and pathogens on the surface structure of Norway spruce needles  

E-print Network

Interactions of ozone and pathogens on the surface structure of Norway spruce needles K. Ojanperä S spruce current needles consists of small tubes forming an evenly dispersed wax struc- ture. As a result and then a plate-like wax structure (Sauter and Voss, 1986). The life span of healthy needles of Norway spruce

Paris-Sud XI, Université de

391

Factors modulating superoxide dismutase activity in needles of spruce trees (Picea abies L.)  

E-print Network

Factors modulating superoxide dismutase activity in needles of spruce trees (Picea abies L.) A compared SOD activity in needles of healthy and in- jured spruce trees growing in the field. Materials and Methods Experiments were performed with needles from Norway spruce trees (Picea abies L.) growing

Paris-Sud XI, Université de

392

Biodegradable Polymer Needle Having a Trench for Collecting Blood by Capillary Force  

Microsoft Academic Search

This paper proposes a biodegradable polymer (Poly Lactic Acid, called as PLA) needle having a trench for collecting blood. A solid micro needle of polymer can be fabricated by micromolding method. However, a hollow needle is difficult to be fabricated by this method. It is also difficult to fabricate a long hole with ultra high aspect ratio along the centerline

S. Aoyagi; H. Izumi; Y. Isono; K. Makihira; M. Fukuda

2006-01-01

393

Haptic System Design for MRI-Guided Needle Based Prostate Brachytherapy  

E-print Network

Feedback, Needle Driver, Prostate Needle Brachytherapy. 1 INTRODUCTION Prostate cancer is the most common biopsies are performed, yielding about 220,000 new prostate cancer cases [14]. Over 40,000 brachytherapiesHaptic System Design for MRI-Guided Needle Based Prostate Brachytherapy Hao Su Weijian Shang

Camesano, Terri

394

An Investigation of the Penetration Force Profile of the Sewing Machine Needle Point  

Microsoft Academic Search

The distributions of the tangential and radial stresses acting on the yam of a fabric during sewing as the sewing needle is inserted into the fabric have been discussed by means of the mechanical principles of elasticity. The influence on the needle penetration force caused by the shape of the cross section and the profile curve at the needle point

G. Stylios; Y. M. Xu

1995-01-01

395

Pulmonary Tuberculosis Confirmed by Percutaneous Transthoracic Needle Biopsy: Analysis of CT Findings and Review of Correlations with Underlying Lung Disease  

PubMed Central

Background: Pulmonary tuberculosis (TB) can produce unusual radiographic findings. Further, negative sputum and bronchoscopic results are common. Early diagnosis is equally as significant as treatment in the reduction of morbidity and mortality associated with pulmonary TB. Aims: The aim of this study was to assess computed tomography (CT) findings of pulmonary TB, confirmed via percutaneous transthoracic needle biopsy (PTNB), and to correlate these findings with coexisting, underlying, lung diseases if present. Study Design: Cross sectional study. Methods: We selected eighty-four patients who were diagnosed with pulmonary TB by way of PTNB. Initially, acid-fast bacilli smear test results from these patients were negative. CT findings were reviewed to detect the presence of parenchymal abnormalities as follows: nodule(s) (<3 cm in diameter), mass (any masses ?3 cm), daughter nodules, air-space consolidation, cavitation, calcification, lymphadenopathy, mediastinal lymphadenopathy, and associated lung parenchymal disease. Results: The CT findings of pulmonary TB confirmed by PTNB included nodules in 44 of 84 (52.4%) cases; 15 of these 44 cases (34.1%) had daughter nodules. The second most common finding was masses in 24 cases (28.6%), nine of which also had daughter nodules. 16 cases (19.0%) displayed nonsegmental consolidation. Of these 16 cases, four had coexisting usual interstitial pneumonia; four others had emphysema. Two patients with a mass had underlying pneumoconiosis. Conclusion: Nodules or a mass mimicking lung cancer were the most common findings on CT scans in patients with pulmonary TB, confirmed via PTNB. The second most common finding was airspace consolidation. Therefore, PNTB is useful for the accurate diagnosis of pulmonary TB in the following cases: airspace consolidation or mass associated with underlying usual interstitial pneumonia, emphysema mimicking lung malignancy or cases of bacterial pneumonia.

Choo, Ji Young; Lee, Ki Yeol; Kim, Mi-young; Kang, Eun-young; Oh, Yu Whan; Lee, Seung Hwa; Seo, Bo Kyung; Je, Bo Kyung

2014-01-01

396

Needle knife papillotomy: how safe and how effective?  

Microsoft Academic Search

Between January 1986 and July 1988 needle knife papillotomy was attempted in 103 patients after failure of conventional access for endoscopic sphincterotomy (96 cases) or diagnostic cholangiography (seven cases). Access was obtained at the same session in 36 cases and at a subsequent attempt within 2 to 5 days in a further 43, an overall success rate of 77%. The

J F Dowsett; A A Polydorou; D Vaira; L M DAnna; M Ashraf; J Croker; P R Salmon; R C Russell; A R Hatfield

1990-01-01

397

Percutaneous needle placement using laser guidance: a practical solution  

NASA Astrophysics Data System (ADS)

In interventional radiology, various navigation technologies have emerged aiming to improve the accuracy of device deployment and potentially the clinical outcomes of minimally invasive procedures. While these technologies' performance has been explored extensively, their impact on daily clinical practice remains undetermined due to the additional cost and complexity, modification of standard devices (e.g. electromagnetic tracking), and different levels of experience among physicians. Taking these factors into consideration, a robotic laser guidance system for percutaneous needle placement is developed. The laser guidance system projects a laser guide line onto the skin entry point of the patient, helping the physician to align the needle with the planned path of the preoperative CT scan. To minimize changes to the standard workflow, the robot is integrated with the CT scanner via optical tracking. As a result, no registration between the robot and CT is needed. The robot can compensate for the motion of the equipment and keep the laser guide line aligned with the biopsy path in real-time. Phantom experiments showed that the guidance system can benefit physicians at different skill levels, while clinical studies showed improved accuracy over conventional freehand needle insertion. The technology is safe, easy to use, and does not involve additional disposable costs. It is our expectation that this technology can be accepted by interventional radiologists for CT guided needle placement procedures.

Xu, Sheng; Kapoor, Ankur; Abi-Jaoudeh, Nadine; Imbesi, Kimberly; Hong, Cheng William; Mazilu, Dumitru; Sharma, Karun; Venkatesan, Aradhana M.; Levy, Elliot; Wood, Bradford J.

2013-03-01

398

Laser therapy and needling in myofascial trigger point deactivation.  

PubMed

The aim of this study was to evaluate different approaches to deactivating myofascial trigger points (MTPs). Twenty-one women with bilateral MTPs in the masseter muscle were randomly divided into three groups: laser therapy, needle treatment and control. Treatment effectiveness was evaluated after four sessions with intervals ranging between 48 and 72 h. Quantitative and qualitative methods were used to measure pain perception/sensation. The Wilcoxon test based on results expressed on a visual analog scale (VAS) demonstrated a significant (P < 0.05) decrease in pain only in the laser and needle treatments groups, although a significant increase in the pressure pain threshold was evident only for needling with anesthetic injection (P = 0.0469), and laser therapy at a dose of 4 J/cm² (P = 0.0156). Based on these results, it was concluded that four sessions of needling with 2% lidocaine injection with intervals between 48 and 72 h without a vasoconstrictor, or laser therapy at a dose of 4 J/cm², are effective for deactivation of MTPs. PMID:23748458

Uemoto, Luciana; Garcia, Marco Antonio C; Gouvêa, Cresus Vinicius D; Vilella, Oswaldo V; Alfaya, Thays A

2013-01-01

399

Sensorless Motion Planning for Medical Needle Insertion in Deformable Tissue  

E-print Network

such as biopsies, anesthesia drug injections, and brachytherapy cancer treatments require inserting a needle to radioactive seed implantation during permanent seed prostate brachytherapy to minimize seed placement error prostate cancer treatment, an experienced physician implanting radioactive seeds in 20 patients using

O'Brien, James F.

400

Interactive needle insertions in 3D nonlinear material  

E-print Network

directly in the tumor. The primary application of brachytherapy is prostate cancer. In this application] also simulate needle insertion using the FEM, and specifically target brachytherapy for prostate cancer a tissue specimen. Another application is brachytherapy, treating cancer by inserting radioactive seeds

Utrecht, Universiteit

401

Protect Yourself, Protect Others: Safe Options for Home Needle Disposal  

MedlinePLUS

... Air Travel Before you fly, check the Transportation Security Administration (TSA) Web site (www.tsa.gov) for up-to-date rules on what to do with your needles when you travel. To make your trip through airport security easier, make sure your medicines are labeled with ...

402

The effects of diesel injector needle motion on spray structure.  

SciTech Connect

The internal structure of diesel fuel injectors is known to have a significant impact on the steady-state fuel distribution within the spray. However, little experimental or computational work has been performed on the dynamics of fuel injectors. Recent studies have shown that it is possible to measure the three-dimensional geometry of the injector nozzle, and to track changes in that geometry as the needle opens and closes in real time. This has enabled the dynamics of the injector to be compared with the dynamics of the spray, and allows computational fluid dynamics (CFD) simulations to use realistic time-dependent flow passage geometries. In this study, X-ray phase-enhanced imaging has been used to perform time-resolved imaging of the needle seat area in several common-rail diesel injection nozzles. The fuel distributions of the sprays emitted by these injectors were also studied with fast X-ray radiography. Correlations between eccentric motions of the injector needle valve and oscillations in the fuel density as it emerges from the nozzle are examined. CFD modeling is used to interpret the effect of needle motion on fuel flow.

Powell, C. F.; Kastengren, A. L.; Liu, Z.; Fezzaa, K. (Energy Systems); ( XSD)

2011-01-01

403

The Single Needle Lockstitch Machine. [Setting a Collar.] Module 5.  

ERIC Educational Resources Information Center

This module on sewing collars, one in a series on the single needle lockstitch sewing machine for student self-study, contains three sections. Each section includes the following parts: an introduction, directions, an objective, learning activities, student information, student self-check, check-out activities, and an instructor's final checklist.…

South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

404

The Single Needle Lockstitch Machine. [Sewing Seams.] Module 4.  

ERIC Educational Resources Information Center

This module on sewing seams, one in a series on the single needle lockstitch sewing machine for student self-study, contains three sections. Each section includes the following parts: an introduction, directions, an objective, learning activities, student information, student self-check, check-out activities, and an instructor's final checklist.…

South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

405

The Single Needle Lockstitch Machine. [Constructing Darts.] Module 3.  

ERIC Educational Resources Information Center

This module on constructing darts, one in a series on the single needle lockstitch sewing machine for student self-study, contains two sections. Each section includes the following parts: an introduction, directions, an objective, learning activities, student information, student self-check, check-out activities, and an instructor's final…

South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

406

The Single Needle Lockstitch Machine. [Setting Zippers.] Module 8.  

ERIC Educational Resources Information Center

This module on setting zippers, one in a series on the single needle lockstitch sewing machine for student self-study, contains five sections. Each section includes the following parts: an introduction, directions, an objective, learning activities, student information, student self-check, check-out activities, and an instructor's final checklist.…

South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

407

Gene expression analysis in serial liver fine needle aspirates.  

PubMed

No method with low morbidity presently exists for obtaining serial hepatic gene expression measurements in humans. While hepatic fine needle aspiration (FNA) has lower morbidity than core needle biopsy, applicability is limited due to blood contamination, which confounds quantification of gene expression changes. The aim of this study was to validate FNA for assessment of hepatic gene expression. Liver needle biopsies and FNA procedures were simultaneously performed on 17 patients with chronic hepatitis C virus infection with an additional FNA procedure 1 week later. Nine patients had mild/moderate fibrosis and eight advanced fibrosis. Gene expression profiling was performed using Affymetrix microarrays and TaqMan qPCR; pathway analysis was performed using Ingenuity. We developed a novel strategy that applies liver-enriched normalization genes to determine the percentage of liver in the FNA sample, which enables accurate gene expression measurements overcoming biases derived from blood contamination. We obtained almost identical gene expression results (? = 0.99, P < 0.0001) comparing needle biopsy and FNA samples for 21 preselected genes. Gene expression results were also validated in dogs. These data suggest that liver FNA is a reliable method for serial hepatic tissue sampling with potential utility for a variety of preclinical and clinical applications. PMID:24475909

Lejnine, S; Marton, M J; Wang, I-M; Howell, B J; Webber, A L; Maxwell, J W; Shire, N; Malkov, V; Lunceford, J; Zeremski, M; Sun, A; Ruddy, M; Talal, A H

2015-01-01

408

Virtual Remote Center of Motion Control for Needle Placement Robots  

E-print Network

or registering the surgical tool to the imager, and a five degree-of- freedom (DOF) robot comprised of three prismatic DOF and two rotational DOF. The robot can be unencoded, uncalibrated, and does not require pre research in robot- assisted needle placement procedures. Robots have the potential to manipulate in

Webster III, Robert James

409

CYTOPATHOLOGY Indeterminate Fine-Needle Aspiration of the Breast  

E-print Network

system computed a benign or malignant diagnosis and a corresponding probability of malignancy for each129 CANCER CYTOPATHOLOGY Indeterminate Fine-Needle Aspiration of the Breast Image Analysis-Assisted Street, Ph.D. 3 sive diagnosis, often prompting surgical biopsy. Surgery is justified in some ofOlvi L

Street, Nick

410

Steering of Flexible Needles Combining Kinesthetic and Vibratory Force Feedback  

E-print Network

-tissue is a minimally inva- sive surgical procedure which demands high accuracy. In this respect, robotic systems an ultrasound imaging system, and, from that, it computes needle's ideal position and orientation to reach surgical systems can greatly improve the accuracy and safety of surgical procedures. They can filter out

Siena, Università di

411

Does sunspot number calibration by the ``magnetic needle'' make sense?  

E-print Network

) that the strength of the heliospheric magnetic field was more than doubled during the last century, in agreement with a solar magnetic field model and the observed sunspot numbers (Solanki et al., 2000, 2002). The increasingDoes sunspot number calibration by the ``magnetic needle'' make sense? K. Mursula a,Ã?, I. Usoskin b

Usoskin, Ilya G.

412

Experimental platform for intra-uterine needle placement procedures  

NASA Astrophysics Data System (ADS)

A framework has been investigated to enable a variety of comparative studies in the context of needle-based gynaecological brachytherapy. Our aim was to create an anthropomorphic phantom-based platform. The three main elements of the platform are the organ model, needle guide, and needle drive. These have been studied and designed to replicate the close environment of brachytherapy treatment for cervical cancer. Key features were created with the help of collaborating interventional radio-oncologists and the observations made in the operating room. A phantom box, representing the uterus model, has been developed considering available surgical analogies and operational limitations, such as organs at risk. A modular phantom-based platform has been designed and prototyped with the capability of providing various boundary conditions for the target organ. By mimicking the female pelvic floor, this framework has been used to compare a variety of needle insertion techniques and configurations for cervical and uterine interventions. The results showed that the proposed methodology is useful for the investigation of quantifiable experiments in the intraabdominal and pelvic regions.

Madjidi, Yashar; Haidegger, Tamás.; Ptacek, Wolfgang; Berger, Daniel; Kirisits, Christian; Kronreif, Gernot; Fichtinger, Gabor

2013-03-01

413

Rare potential complications of thyroid fine needle biopsy  

PubMed Central

Thyroid fine needle biopsy (FNB) is the procedure of choice for the management of thyroid nodules. Serious complications after FNB are rare, but there is also an underestimation of complication risk because of record, selection and publication biases. Hypothesis: Apart from the well-documented post-FNB complications, we hypothesized that there are potential complications following FNB, albeit supported by limited evidence in the literature. According to our hypothesis, there may be five distinct expected rare complications: 1) cyst fluid leakage; 2) anaphylactic reaction; 3) pneumothorax; 4) thromboembolism and 5) needle tract seeding of medullary thyroid carcinoma (MTC) or thyroid lymphoma. Conclusions: Cyst fluid leakage and pneumothorax may be of minimal clinical significance. Needle tract seeding of MTC or thyroid lymphoma may not have significant clinical consequences, if someone considers the easiness and effectiveness of surgical removal of needle tract seeding in cases of differentiated thyroid carcinoma. On the contrary, anaphylactic reaction or thromboembolism may be life-threatening. The performers of thyroid FNB are hereby encouraged to publish these complications, if they ever occur, because awareness of them could render FNB even safer. PMID:22110291

Polyzos, S A; Anastasilakis, A D

2011-01-01

414

Robotic systems for percutaneous needle-guided interventions.  

PubMed

Abstract Several groups have developed robotic systems for invasive medical procedures. In this article we will focus on selected robotic systems for percutaneous needle-guided interventions using CT or MR imaging. We present six interventional robotic systems designed to work with imaging modalities such as CT, Cone-beam CT and MRI. The details of each system are given along with any phantom, animal, or human trials performed with each particular robot. Although each of these systems has specific features, they are all of great clinical value since they provide very stable needle guidance -- even for angulated approaches, they may allow access to lesions when the width of the CT- or MR- gantry would limit the access for a biopsy needle or other interventional tools such as thermal ablation probes. Then, such a robot may be able to guide the needle into the most promising region of the lesion without the need for a second contrast injection. Thus, more efficacious characterization and treatment, particularly for lesions that are difficult to target, can be anticipated. Although more research and clinical trials are certainly needed, it is, however, our belief that robotic systems will be an important part of future interventions. PMID:25421786

Kettenbach, Joachim; Kronreif, Gernot

2015-02-01

415

Robotic Needle Steering: Design, Modeling, Planning, and Image Guidance  

E-print Network

, radioactive seeds, and thermal ablation. In addition to therapeutic delivery, needles are also commonly used in thermal tumor ablation, be- cause dosimetry and target planning can be updated from one insertion for diagnostic procedures, such as biopsy. As biosensors, manipulators, ablation tools, and other "end

416

Robotically Assisted Spine Needle Placement: Program Plan and Cadaver Study  

Microsoft Academic Search

Gives an overview of our program plan in robotically assisted spine procedures and details an initial cadaver study. Low back pain is a common medical problem, and minimally invasive procedures such as nerve blocks are rapidly growing in popularity as a potential method of treatment. To assist the physician in needle placement during these procedures, we have investigated using a

Kevin Clearyl; David Lindisch; Filip Banovac; Vance Watson; Dan Stoianovici

2001-01-01

417

Alternative to surgery of treatment of unruptured interstitial pregnancy: 15 cases of medical treatment  

Microsoft Academic Search

Objective: To evaluate medical treatment of interstitial pregnancy. Methods: This series was a retrospective study of medical treatment of interstitial pregnancies which was managed in two French Departments of Obstetrics and Gynecology (Bichat public Hospital, Paris and A. Béclère public Hospital, Clamart, France). Fifteen patients with clear evidence of an unruptured interstitial pregnancy were treated by injection of methotrexate (MTX)

Jean-Louis Benifla; Hervé Fernandez; Eric Sebban; Emile Darai; René Frydman; Patrick Madelenat

1996-01-01

418

Analysis of Glucose Concentration in Interstitial Fluid by Micro Surface Plasmon Resonance Sensor  

Microsoft Academic Search

A novel minimally invasive way to measure blood glucose concentration is proposed by combining interstitial fluid (ISF) transdermal extraction and surface plasmon resonance (SPR) detection. 55 kHz low-frequency ultrasound pulses are applied for 30 seconds to enhance the skin permeability and then interstitial fluid is extracted out of skin by vacuum. The glucose concentration in the interstitial fluid is determined

Dachao Li; Xian Huang; Haixia Yu; Xiaotang Hu; Kexin Xu; Robert C Roberts; Norman Tien

2007-01-01

419

Analysis of Blood Glucose Concentration by Interstitial Fluid Extracted in a Minimally Invasive way  

Microsoft Academic Search

A novel minimally invasive way to measure blood glucose concentration is proposed by combining interstitial fluid (ISF) transdermal extraction and surface plasmon resonance (SPR) detection. 55 kHz low-frequency ultrasound pulses are applied for 30 seconds to enhance the skin permeability and then interstitial fluid is extracted out of skin by vacuum. The glucose concentration in the interstitial fluid is determined

Xiaotang Hu; Kexin Xu; Xuejun Cao; Xinghua Qu; Dachao Li

2009-01-01

420

First-principles study of He point-defects in HCP rare-earth metals  

SciTech Connect

He defect properties in Sc, Y, Gd, Tb, Dy, Ho, Er and Lu were studied using first-principles calculations based on density functional theory. The results indicate that the formation energy of an interstitial He atom is smaller than that of a substitutional He atom in all hcp rare-earth metals considered. Furthermore, the tetrahedral interstitial position is more favorable than an octahedral position for He defects. The results are compared with those from bcc and fcc metals.

Li, Yang; Chen, Ru; Peng, SM; Long, XG; Wu, Z.; Gao, Fei; Zu, Xiaotao

2011-05-01

421

Drug-induced Acute Interstitial Nephritis: Pathology, Pathogenesis, and Treatment.  

PubMed

Drug-induced acute interstitial nephritis (DAIN) is a common cause of acute kidney injury and often presents as an unexplained rise in serum creatinine level. Kidney biopsy is therefore frequently required to make a definitive diagnosis. The hallmark pathologic features of DAIN are interstitial edema, interstitial inflammation, and tubulitis with a predominance of CD4+ T lymphocytes and mononuclear cells, with variable numbers of eosinophils. This is a result of a type B idiosyncratic non-immunoglobulin-E-mediated immune reaction marked by cell-mediated immune injury to the renal tubulointerstitium. The drug becomes immunogenic via various mechanisms such as haptenization, antigen mimicry, and neo-antigen formation. Renal interstitial dendritic cells, and renal tubular epithelial cells play an important role in further propagating this immunologic injury. Acute DAIN can progress within days to weeks to a chronic form triggered by fibroblast activation and manifested as interstitial fibrosis and tubular atrophy. The mainstay of treatment of DAIN is discontinuation of the offending drug. Incomplete renal recovery is seen in one-third of the patients and depends on the duration of injury prior to diagnosis. Use of steroids for treatment of DAIN makes biological sense, but lack of randomized controlled trials and conflicting data from retrospective studies makes the approach unclear. Positive effects include faster recovery of kidney function, more complete recovery with less chronic kidney disease, and reduced need for chronic dialysis. Therefore, it seems reasonable to employ corticosteroids in patients that do not rapidly improve 3 to 5 days following discontinuation of the offending agent. PMID:25599729

Krishnan, Namrata; Perazella, Mark A

2015-01-01

422

Microdefects and self-interstitial diffusion in crystalline silicon  

SciTech Connect

In this thesis, a study is presented of D-defects and self-interstitial diffusion in silicon using Li ion (Li{sup +}) drifting in an electric field and transmission electron microscopy (TEM). Obstruction of Li{sup +} drifting has been found in wafers from certain but not all FZ p-type Si. Incomplete Li{sup +} drifting always occurs in the central region of the wafers. This work established that interstitial oxygen is not responsible for hindering Li{sup +} drifting. TEM was performed on a samples from the partially Li{sup +} drifted area and compared to regions without D-defects. Precipitates were found only in the region containing D-defects that had partially Li{sup +} drifted. This result indicates D-defects are responsible for the precipitation that halts the Li{sup +} drift process. Nitrogen (N) doping has been shown to eliminate D-defects as measured by conventional techniques. Li{sup +} drifting and D-defects provide a useful means to study Si self-interstitial diffusion. The process modeling program SUPREM-IV was used to simulate the results of Si self-interstitial diffusion obtained from Li{sup +} drifting experiments. Anomalous results from the Si self-interstitial diffusion experiments forced a re-examination of the possibility of thermal dissociation of D-defects. Thermal annealing experiments that were performed support this possibility. A review of the current literature illustrates the need for more research on the effects of thermal processing on FZ Si to understand the dissolution kinetics of D-defects.

Knowlton, W.B.

1998-05-01

423

Chronic effect of cadmium in sediments on colonization by benthic marine organisms: An evaluation of the role of interstitial cadmium and acid-volatile sulfide in biological availability  

SciTech Connect

The role of interstitial cadmium and acid-volatile sulfide (AVS) in controlling the bioavailability of sediment-associated metal was examined using the chronic saltwater benthic colonization test. Sediments were spiked to achieve nominal cadmium/AVS molar ratios of 0.0 (control), 0.1, 0.8, and 3.0 in this 118-d test. Oxidation of AVS in the surficial 2.4 cm within 2 to 4 weeks resulted in sulfide profiles similar to those occurring naturally in local sediments. In the nominal 0.1 cadmium/AVS treatment measured simultaneously extracted metal (SEM{sub Cd}) was always less than AVS. Interstitial cadmium concentrations were less than those likely to cause biological effects. No significant biological effects were detected. In the nominal 0.8 cadmium/AVS treatment, measured SEM{sub Cd} commonly exceeded AVS in the surficial 2.4 cm of sediment. Interstitial cadmium concentrations were of likely toxicological significance to highly sensitive species. Shifts in the presence or absence over all taxa, and fewer macrobenthic polychaetes (Mediomastus ambiseta, Streblospio benedicti, and Podarke obscurea) and unidentified meiofaunal nematodes, were observed. In the nominal 3.0 cadmium/AVS treatment, concentrations of SEM{sub Cd} were always greater than AVS throughout the sediment column. Interstitial cadmium ranged from 28,000 to 174,000 {micro}g/L. In addition to the effects above, the sediments were colonized by fewer macrobenthic species, polychaete species, and harpacticoids; had lower densities of diatoms; lacked bivalve molluscs; and exhibited other impacts. Over all treatments, the observed biological responses were consistent with SEM{sub Cd}/AVS ratios in surficial sediments and interstitial water cadmium concentrations.

Hansen, D.J.; Berry, W.J.; Benyi, S.J. [Environmental Protection Agency, Narragansett, RI (United States); Mahony, J.D. [Manhattan Coll., New York, NY (United States). Dept. of Environmental Engineering; Corbin, J.M. [Texas Natural Resource Conservation Commission, Austin, TX (United States). Environmental Assessment Div.; Pratt, S.D. [Univ. of Rhode Island, Narragansett, RI (United States). Graduate School of Oceanography; Toro, D.M. di [Manhattan Coll., New York, NY (United States). Dept. of Environmental Engineering]|[HydroQual, Inc., Mahwah, NJ (United States); Abel, M.B. [Univ. of Rhode Island, Kingston, RI (United States). Botany Dept.

1996-12-01

424

Needle-knife fistulotomy versus needle-knife precut papillotomy for the treatment of common bile duct stones  

Microsoft Academic Search

Background: The aim of this prospective study was to evaluate and compare the efficacy and safety of two different precutting techniques in the treatment of 103 consecutive patients with choledocholithiasis. Methods: The patients were randomized into two groups. The first group included 74 patients who underwent needle-knife fistulotomy avoiding the papillary orifice followed by standard papillotomy. Fifty-two of these patients

Christos Mavrogiannis; Christos Liatsos; Andreas Romanos; Christos Petoumenos; Antonios Nakos; Gerasimos Karvountzis

1999-01-01

425

Using a 3D Needle Tissue Interaction Loading basis to optimize the design of an instrumented needle  

E-print Network

] and active (instrumentation of the device) [Park, 2010] tracking of medical devices have been developedUsing a 3D Needle ­Tissue Interaction Loading basis to optimize the design of an instrumented; Optimal positioning of microgauges 1. Introduction Many medical interventions are based on the insertion

Paris-Sud XI, Université de

426

Barrier Coatings for Refractory Metals and Superalloys  

SciTech Connect

In the closed working fluid loop of the proposed Prometheus space nuclear power plant (SNPP), there is the potential for reaction of core and plant structural materials with gas phase impurities and gas phase transport of interstitial elements between superalloy and refractory metal alloy components during service. Primary concerns are surface oxidation, interstitial embrittlement of refractory metals and decarburization of superalloys. In parallel with kinetic investigations, this letter evaluates the ability of potential coatings to prevent or impede communication between reactor and plant components. Key coating requirements are identified and current technology coating materials are reviewed relative to these requirements. Candidate coatings are identified for future evaluation based on current knowledge of design parameters and anticipated environment. Coatings were identified for superalloys and refractory metals to provide diffusion barriers to interstitial transport and act as reactive barriers to potential oxidation. Due to their high stability at low oxygen potential, alumina formers are most promising for oxidation protection given the anticipated coolant gas chemistry. A sublayer of iridium is recommended to provide inherent diffusion resistance to interstitials. Based on specific base metal selection, a thin film substrate--coating interdiffusion barrier layer may be necessary to meet mission life.

SM Sabol; BT Randall; JD Edington; CJ Larkin; BJ Close

2006-02-23

427

Scattering from a random layer embedded with dielectric needles. [for applications to coniferous vegetation  

NASA Technical Reports Server (NTRS)

Intensity scattering from a random layer imbedded with small dielectric needles is studied for applications to coniferous vegetation. The phase matrix of a thin needle whose length may be appreciable compared to the incident wavelength is presented. The effects of needle orientation on scattering is taken into account by averaging the phase function over angles of orientation. The backscattering coefficient from the layer is computed by solving the radiative transfer equation. The effects of operating frequency, orientation and size of a needle on like- and cross-backscattering are demonstrated. It was found that in backscattering angular trends are mainly controlled by the orientation of the needles.

Eom, H. J.; Fung, A. K.

1986-01-01

428

Randomized Trial Comparing the Flexible 19G and 25G Needles for Endoscopic Ultrasound-Guided Fine Needle Aspiration of Solid Pancreatic Mass Lesions  

PubMed Central

Objectives Although a large gauge needle can procure more tissue at endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), its advantage over smaller needles is unclear. This study compared flexible 19G and 25G needles for EUS-FNA of solid pancreatic masses. Methods This was a randomized trial of patients undergoing EUS-FNA of pancreatic masses using flexible 19G or 25G needle. Main outcome measure was to compare median number of passes for on-site diagnosis. Secondary measures were to compare specimen bloodiness, complications, technical failures, and histological core tissue procurement. Results One hundred patients were randomized to EUS-FNA using flexible 19G or 25G needle. Median of 1 pass was required to achieve on-site diagnosis of 96% and 92% (P = 0.68) in 19G and 25G cohorts. There was no significant difference in technical failure (0% vs 2%, P = 0.99) or adverse events (2% vs 0%, P = 0.99) between 19G and 25G cohorts. Although histological core tissue procurement was significantly better with flexible 19G needle (88% vs 44%, P < 0.001), specimens were bloodier (severe bloodiness, 36% vs 4%; P < 0.001). Conclusions As there is no significant difference in the performance of flexible 19G and 25G needles, needle choice for sampling pancreatic masses should be based on endoscopist preference and need for histology. PMID:25232713

Ramesh, Jayapal; Bang, Ji Young; Hebert-Magee, Shantel; Trevino, Jessica; Eltoum, Isam; Frost, Andra; Hasan, Muhammad K.; Logue, Amy; Hawes, Robert; Varadarajulu, Shyam

2015-01-01

429

Site occupancy of interstitial deuterium atoms in face-centred cubic iron  

PubMed Central

Hydrogen composition and occupation state provide basic information for understanding various properties of the metal–hydrogen system, ranging from microscopic properties such as hydrogen diffusion to macroscopic properties such as phase stability. Here the deuterization process of face-centred cubic Fe to form solid-solution face-centred cubic FeDx is investigated using in situ neutron diffraction at high temperature and pressure. In a completely deuterized specimen at 988?K and 6.3?GPa, deuterium atoms occupy octahedral and tetrahedral interstitial sites with an occupancy of 0.532(9) and 0.056(5), respectively, giving a deuterium composition x of 0.64(1). During deuterization, the metal lattice expands approximately linearly with deuterium composition at a rate of 2.21?Å3 per deuterium atom. The minor occupation of the tetrahedral site is thermally driven by the intersite movement of deuterium atoms along the ‹111› direction in the face-centred cubic metal lattice. PMID:25256789

Machida, Akihiko; Saitoh, Hiroyuki; Sugimoto, Hidehiko; Hattori, Takanori; Sano-Furukawa, Asami; Endo, Naruki; Katayama, Yoshinori; Iizuka, Riko; Sato, Toyoto; Matsuo, Motoaki; Orimo, Shin-ichi; Aoki, Katsutoshi

2014-01-01

430

Design, calibration and evaluation of a robotic needle-positioning system for small animal imaging applications  

NASA Astrophysics Data System (ADS)

A needle-positioning robot has been developed for image-guided interventions in small animal research models. The device is designed to position a needle with an error <=100 µm. The robot has two rotational axes (pitch and roll) to control needle orientation, and one linear axis to perform needle insertion. The three axes intersect at a single point to create a remote centre of motion (RCM) that acts as a fulcrum for the orientation of the needle. The RCM corresponds to the skin-entry point of the needle into the animal. The robot was calibrated to ensure that the three axes intersected at a single point defining an RCM and that the needle tip was positioned at the RCM. Needle-positioning accuracy and precision were quantified in Cartesian coordinates at ten target locations in the plane of each rotational axis. The measured needle-positioning accuracy in free space was 54 ± 12 µm for the pitch axis plane and 91 ± 21 µm for the roll axis plane. The measured needle-positioning precision was 15 and 17 µm for the pitch and roll axes planes, respectively. The robot's ability to insert a needle into a tumour in a euthanized mouse was demonstrated.

Waspe, Adam C.; Cakiroglu, H. Jason; Lacefield, James C.; Fenster, Aaron

2007-04-01

431

In vivo motion and force measurement of surgical needle intervention during prostate brachytherapy  

SciTech Connect

In this paper, we present needle insertion forces and motion trajectories measured during actual brachytherapy needle insertion while implanting radioactive seeds in the prostate glands of 20 different patients. The needle motion was captured using ultrasound images and a 6 degree-of-freedom electromagnetic-based position sensor. Needle velocity was computed from the position information and the corresponding time stamps. From in vivo data we found the maximum needle insertion forces to be about 15.6 and 8.9 N for 17 gauge (1.47 mm) and 18 gauge (1.27 mm) needles, respectively. Part of this difference in insertion forces is due to the needle size difference (17G and 18G) and the other part is due to the difference in tissue properties that are specific to the individual patient. Some transverse forces were observed, which are attributed to several factors such as tissue heterogeneity, organ movement, human factors in surgery, and the interaction between the template and the needle. However, theses insertion forces are significantly responsible for needle deviation from the desired trajectory and target movement. Therefore, a proper selection of needle and modulated velocity (translational and rotational) may reduce the tissue deformation and target movement by reducing insertion forces and thereby improve the seed delivery accuracy. The knowledge gleaned from this study promises to be useful for not only designing mechanical/robotic systems but also developing a predictive deformation model of the prostate and real-time adaptive controlling of the needle.

Podder, Tarun; Clark, Douglas; Sherman, Jason; Fuller, Dave; Messing, Edward; Rubens, Deborah; Strang, John; Brasacchio, Ralph; Liao, Lydia; Ng, W.-S.; Yu Yan [Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642 (United States); Departments of Radiation Oncology and Surgery, University of Rochester Medical Center, Rochester, New York 14642 (United States); Departments of Radiology and Surgery, University of Rochester Medical Center, Rochester, New York 14642 (United States) and Department of Biomedical Engineering, University of Rochester, Rochester, New York 14642 (United States); Department of Radiology, University of Rochester Medical Center, Rochester, New York 14642 (United States); Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642 (United States); Departments of Radiology and Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642 (United States); School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798 (Singapore); Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642 and Department of Biomedical Engineering, University of Rochester, New York 14642 (United States)

2006-08-15

432

Autonomous real-time interventional scan plane control with a 3-D shape-sensing needle.  

PubMed

This study demonstrates real-time scan plane control dependent on three-dimensional needle bending, as measured from magnetic resonance imaging (MRI)-compatible optical strain sensors. A biopsy needle with embedded fiber Bragg grating (FBG) sensors to measure surface strains is used to estimate its full 3-D shape and control the imaging plane of an MR scanner in real-time, based on the needle's estimated profile. The needle and scanner coordinate frames are registered to each other via miniature radio-frequency (RF) tracking coils, and the scan planes autonomously track the needle as it is deflected, keeping its tip in view. A 3-D needle annotation is superimposed over MR-images presented in a 3-D environment with the scanner's frame of reference. Scan planes calculated based on the FBG sensors successfully follow the tip of the needle. Experiments using the FBG sensors and RF coils to track the needle shape and location in real-time had an average root mean square error of 4.2 mm when comparing the estimated shape to the needle profile as seen in high resolution MR images. This positional variance is less than the image artifact caused by the needle in high resolution SPGR (spoiled gradient recalled) images. Optical fiber strain sensors can estimate a needle's profile in real-time and be used for MRI scan plane control to potentially enable faster and more accurate physician response. PMID:24968093

Elayaperumal, Santhi; Plata, Juan Camilo; Holbrook, Andrew B; Park, Yong-Lae; Pauly, Kim Butts; Daniel, Bruce L; Cutkosky, Mark R

2014-11-01

433

CT-guided biopsy of lung lesions: defining the best needle option for a specific diagnosis  

PubMed Central

OBJECTIVES: To evaluate the performance of fine and cutting needles in computed tomography guided-biopsy of lung lesions suspicious for malignancy and to determine which technique is the best option for a specific diagnosis. METHODS: This retrospective study reviewed the data from 362 (71.6%) patients who underwent fine-needle aspiration biopsy and from 97 (19.7%) patients who underwent cutting-needle biopsy between January 2006 and December 2011. The data concerning demographic and lesion characteristics, procedures, biopsy sample adequacy, specific diagnoses, and complications were collected. The success and complication rates of both biopsy techniques were calculated. RESULTS: Cutting-needle biopsy yielded significantly higher percentages of adequate biopsy samples and specific diagnoses than did fine-needle aspiration biopsy (p<0.05). The sensitivity, specificity, and accuracy of cutting-needle biopsy were 93.8%, 97.3%, and 95.2%, respectively; those of fine-needle aspiration biopsy were 82.6%, 81.3%, and 81.8%, respectively (all p<0.05). The incidence of pneumothorax was higher for fine-needle aspiration biopsy, and that of hematoma was higher for cutting-needle biopsy (both p<0.05). CONCLUSIONS: Our experience using these two techniques for computed tomography-guided percutaneous biopsy showed that cutting-needle biopsy yielded better results than did fine-needle aspiration biopsy and that there was no significant increase in complication rates to indicate the best option for specific diagnoses. PMID:24838899

Guimarães, Marcos Duarte; Marchiori, Edson; Hochhegger, Bruno; Chojniak, Rubens; Gross, Jefferson Luiz

2014-01-01

434

Modulation of an optical needle's reflectivity alters the average photon path through scattering media.  

PubMed

We introduce the concept of deliberate placement of absorbers to alter the average path of photons through tissue for a biomedical optical device. By changing the reflectivity of a needle that separates a source and detector, the average photon path through a turbid medium can be changed. Totally reflective needles have photon scattering density functions similar to a point source and detector in an infinite medium. An absorbing needle moves the average photon path of photons that reach the detector away from the needle. Thus, by modulating the reflectivity of the needle, it is possible to modify the sensitive volume, and simple tomography data should be possible. These results are confirmed by Monte Carlo simulations and experiment. Experiments include moving a black target relative to an optical "needle" and measuring the resulting intensity and phase lag of light reaching a detector at the distal end of the needle. PMID:16526900

Simonson, Paul; D'Amico, Enrico; Gratton, Enrico

2006-01-01

435

Effect of suction on specimen size in fine-needle aspiration biopsy.  

PubMed

High incidences of unsatisfactory specimens in fine-needle aspiration biopsy for cytology have been reported previously. Inappropriate aspiration techniques may account partly for this. In this study, the effect of suction on specimen size was studied in vitro using an automatic sampler. Bovine liver, testis, and pig's kidney were used as target tissues and biopsies were performed with 18-, 20- and 22-gauge needles. Specimen weight increased rapidly and linearly with suction force (P less than .001), regardless of the target tissue or needle diameter, when standard needle movement was applied. In the absence of needle movement, the suction force, rate of increase of suction, and duration of suction had no effect on the weight of the specimens. Needle movement alone, without suction, also produced meager specimens. Suction alone does not seem to tear fragments off target tissues. Nevertheless, in combination with needle movement, suction force plays an important role in the determination of specimen size. PMID:2254053

Kreula, J; Virkkunen, P; Bondestam, S

1990-11-01

436

The Path-of-Probability Algorithm for Steering and Feedback Control of Flexible Needles  

PubMed Central

In this paper we develop a new framework for path planning of flexible needles with bevel tips. Based on a stochastic model of needle steering, the probability density function for the needle tip pose is approximated as a Gaussian. The means and covariances are estimated using an error propagation algorithm which has second order accuracy. Then we adapt the path-of-probability (POP) algorithm to path planning of flexible needles with bevel tips. We demonstrate how our planning algorithm can be used for feedback control of flexible needles. We also derive a closed-form solution for the port placement problem for finding good insertion locations for flexible needles in the case when there are no obstacles. Furthermore, we propose a new method using reference splines with the POP algorithm to solve the path planning problem for flexible needles in more general cases that include obstacles. PMID:21151708

Park, Wooram; Wang, Yunfeng; Chirikjian, Gregory S.

2010-01-01

437

Optimizing prostate needle biopsy through 3D simulation  

NASA Astrophysics Data System (ADS)

Prostate needle biopsy is used for the detection of prostate cancer. The protocol of needle biopsy that is currently routinely used in the clinical environment is the systematic sextant technique, which defines six symmetric locations on the prostate surface for needle insertion. However, this protocol has been developed based on the long-term observation and experience of urologists. Little quantitative or scientific evidence supports the use of this biopsy technique. In this research, we aim at developing a statistically optimized new prostate needle biopsy protocol to improve the quality of diagnosis of prostate cancer. This new protocol will be developed by using a three-dimensional (3-D) computer- based probability map of prostate cancer. For this purpose, we have developed a computer-based 3-D visualization and simulation system with prostate models constructed from the digitized prostate specimens, in which the process of prostate needle biopsy can be simulated automatically by the computer. In this paper, we first develop an interactive biopsy simulation mode in the system, and evaluate the performance of the automatic biopsy simulation with the sextant biopsy protocol by comparing the results by the urologist using the interactive simulation mode with respect to 53 prostate models. This is required to confirm that the automatic simulation is accurate and reliable enough for the simulation with respect to a large number of prostate models. Then we compare the performance of the existing protocols using the automatic biopsy simulation system with respect to 107 prostate models, which will statistically identify if one protocol is better than another. Since the estimation of tumor volume is extremely important in determining the significance of a tumor and in deciding appropriate treatment methods, we further investigate correlation between the tumor volume and the positive core volume with 89 prostate models. This is done in order to develop a method to estimate the tumor volume from the corresponding positive core volumes. Finally, we propose an algorithm for developing a statistically optimized prostate needle biopsy protocol. Preliminary experimental results are also presented.

Zeng, Jianchao; Kaplan, Charles; Xuan, Jian Hua; Sesterhenn, Isabell A.; Lynch, John H.; Freedman, Matthew T.; Mun, Seong K.

1998-06-01

438

In vivo sampling of Verteporfin uptake in pancreas cancer xenograft models: comparison of surface, oral, and interstitial measurements  

NASA Astrophysics Data System (ADS)

Photodynamic therapy (PDT) mediated with Verteporfin is being investigated as a pancreatic cancer treatment in the cases for non-surgical candidates. Tissue response to PDT is based on a number of parameters including photosensitizer (PS) dose, light dose and time interval between light application and PS injection. In this study, PS uptake and distribution in animal leg muscle, oral cavity tissues, pancreas and tumor was measured in vivo using light-induced fluorescence spectroscopy (LIFS) via an Aurora Optics Inc. PDT fluorescence dosimeter. An orthotopic pancreatic cancer model (AsPC-1) was implanted in SCID mice and treated with the PS. Probe measurements were made using a surface probe and an interstitial needle probe before and up to one hour after intravenous tail vein injection of the PS. The study demonstrated that it is possible to correlate in-vivo LIFS measurements of the PS uptake in the pancreas with measurements taken from the oral cavity indicating that light dosimetry of PDT of the pancreas can be ascertained from the LIFS measurements in the oral cavity. These results emphasize the importance of light dosimetry in improving the therapeutic outcome of PDT through light dose adaptation to the relative in situ tissue PS concentration.

Isabelle, Martin; O'Hara, Julia A.; Samkoe, Kimberley S.; Hoopes, P. Jack; Mosse, Sandy; Pereira, Stephen; Hasan, Tayyaba; Pogue, Brian W.

2010-02-01

439

Early diagenesis and chemical characteristics of interstitial water and sediments in the deep deposition bottoms of the Baltic proper  

NASA Astrophysics Data System (ADS)

The nutrient load into the brackish Baltic Sea has increased over the last century. This increase, together with varying deep-water supply, has resulted in a large-scale oxygen deficiency in the deeper basins of the Baltic proper. Moreover, since 1976 hydrogen sulphide has been present in the bottom water of the eastern Gotland basin. In January 1990 it was found up to a depth of 130 m. We collected sediment cores at six locations in the deep basins of the Baltic proper. After extracting the interstitial waters several carbon and nutrient fractions were analyzed, and the interstitial water itself was analyzed with respect to Eh, pH, alkalinity, iron, manganese, ammonium, phosphorus, hydrogen sulphide, chlorinity, sulphate and major alkali and earth metals (Mg, Ca, Na, K, Sr). Thermodynamic equilibrium calculations in combination with data on carbon and nutrient concentration distributions were used as an indirect tool for determining early diagenetic processes that could have been responsible for the variation in the measured parameters observed in the interstitial water and sediments. High concentrations of nutrients and sulphide were found in the interstitial water, especially in the southern and central Baltic proper. Sulphate reduction and subsequent metal sulphide precipitation have induced high carbonate alkalinity and increasing pH values in the euxinic interstitial water with increasing depth in the sediment, and hence it is possible that calcium carbonates and mixed manganese carbonates were precipitated. The dissolution and precipitation of calcium carbonates probably control the upper limit of both the calcium concentration and carbonate alkalinity. Most of the examined interstitial waters were saturated or supersaturated with both pure and mixed manganese carbonates as well as with apatite and anapaite. This indicates that these minerals exhibit slow reaction kinetics or that they are paragenetically formed according to qualitative observation rules, e.g., the Ostwald step rule or Ostwald ripening. The iron concentration was mainly determined by the result of precipitation and dissolution of amorphous oxyhydroxide and acid volatile monosulphide in the oxidized and reduced zones, respectively. Thermodynamic solubility calculations also suggest that there is an ongoing precipitation of manganese sulphide in the Gotland deep. Depletion of sodium, magnesium and strontium in the interstitial water, as compared to prediagenetic conditions, was probably primarily due to an exchange removal of Fe(III) oxyhydroxides (anoxic condition) from certain clay minerals. A close correlation was noted between magnesium and strontium, which implies that the diagenesis of these two elements is similar. The carbon and nitrogen in the sediment samples were present mainly in organic forms; the inorganic fractions normally constituted ?10% of the total amount of these elements. However, the inorganic carbon content in the central part of the Gotland deep was relatively high (2% of d.w. or about 30% of the total carbon content). This enrichment of inorganic carbon was probably mainly due to enhanced authigenic precipitation of mixed manganese carbonates. Phosphorus, on the other hand, was very abundant in inorganically bound fractions. In terms of early diagenesis, the amounts of inorganic phosphorus were governed by the precipitation and dissolution of Fe(III) oxyhydroxides.

Carman, Rolf; Rahm, Lars

1997-05-01

440

3D polymer gel dosimetry and Geant4 Monte Carlo characterization of novel needle based X-ray source  

NASA Astrophysics Data System (ADS)

In the recent years, there have been a few attempts to develop a low energy x-ray radiation sources alternative to conventional radioisotopes used in brachytherapy. So far, all efforts have been centered around the intent to design an interstitial miniaturized x-ray tube. Though direct irradiation of tumors looks very promising, the known insertable miniature x-ray tubes have many limitations: (a) difficulties with focusing and steering the electron beam to the target; (b)necessity to cool the target to increase x-ray production efficiency; (c)impracticability to reduce the diameter of the miniaturized x-ray tube below 4mm (the requirement to decrease the diameter of the x-ray tube and the need to have a cooling system for the target have are mutually exclusive); (c) significant limitations in changing shape and energy of the emitted radiation. The specific aim of this study is to demonstrate the feasibility of a new concept for an insertable low-energy needle x-ray device based on simulation with Geant4 Monte Carlo code and to measure the dose rate distribution for low energy (17.5 keV) x-ray radiation with the 3D polymer gel dosimetry.

Liu, Y.; Sozontov, E.; Safronov, V.; Gutman, G.; Strumban, E.; Jiang, Q.; Li, S.

2010-11-01

441

Sleep disordered breathing in interstitial lung disease: A review  

PubMed Central

Patients with interstitial lung disease commonly exhibit abnormal sleep architecture and increased sleep fragmentation on polysomnography. Fatigue is a frequent complaint, and it is likely that poor sleep quality is a significant contributor. A number of studies have shown that sleep disordered breathing is prevalent in this population, particularly in the idiopathic pulmonary fibrosis subgroup. The factors that predispose these patients to obstructive sleep apnoea are not well understood, however it is believed that reduced caudal traction on the upper airway can enhance collapsibility. Ventilatory control system instability may also be an important factor, particularly in those with increased chemo-responsiveness, and in hypoxic conditions. Transient, repetitive nocturnal oxygen desaturation is frequently observed in interstitial lung disease, both with and without associated obstructive apnoeas. There is increasing evidence that sleep-desaturation is associated with increased mortality, and may be important in the pathogenesis of pulmonary hypertension in this population. PMID:25516856

Troy, Lauren K; Corte, Tamera J

2014-01-01

442

Risk factors in interstitial pneumonitis following allogenic bone marrow transplantation  

SciTech Connect

Total body irradiation is part of the preparatory regimen for allogeneic bone marrow transplantation because of its cytotoxic and immunosuppressive properties. A major toxicity of bone marrow transplantation has been interstitial pneumonitis, which may be, in part, related to the lung irradiation. One hundred and sixty-one consecutive patients receiving allogeneic bone marrow transplantation for leukemia and aplastic anemia at Johns Hopkins Hospital (1968-1979) were retrospectively studied. The present study demonstrated that lung shielding to 600 rad maximum in single dose total body irradiation, fractionation of total body irradiation in comparison to single dose total body irradiation, and absence of graft versus host disease in the leukemia patients, each reduced the risk of interstitial pneumonitis. Total body irradiation significantly reduced the leukemia recurrence rate and/or the failure of remission induction.

Pino Y Torres, J.L.; Bross, D.S.; Lam, W.C.; Wharam, M.D.; Santos, G.W.; Order, S.E.

1982-08-01

443

Masters of miniaturization: convergent evolution among interstitial eukaryotes.  

PubMed

Marine interstitial environments are teeming with an extraordinary diversity of coexisting microeukaryotic lineages collectively called "meiofauna." Interstitial habitats are broadly distributed across the planet, and the complex physical features of these environments have persisted, much like they exist today, throughout the history of eukaryotes, if not longer. Although our general understanding of the biological diversity in these environments is relatively poor, compelling examples of developmental heterochrony (e.g., pedomorphosis) and convergent evolution appear to be widespread among meiofauna. Therefore, an improved understanding of meiofaunal biodiversity is expected to provide some of the deepest insights into the following themes in evolutionary biology: (i) the origins of novel body plans, (ii) macroevolutionary patterns of miniaturization, and (iii) the intersection of evolution and community assembly - e.g., "community convergence" involving distantly related lineages that span the tree of eukaryotes. PMID:20414901

Rundell, Rebecca J; Leander, Brian S

2010-05-01

444

Laparoscopic surgery of interstitial (cornual) pregnancy, a case report  

PubMed Central

We report a successful laparoscopic management of an interstitial pregnancy of a 24- year-old single woman, treated by cornuostomy. The patient was first managed with methotrexate treatment. After the 2. methotrexate administration, the patient suffered from low abdominal pain, and intraabdominal bleeding signs were reported by transvaginal ultrasonograpy. The hemoglobin level was decreased from 12.8 gr/dl to 11.8 gr/dl and the beta hCG level was increased from 8,314 mIU/l to 11,541 mIU/l. The laparoscopic approach to interstitial pregnancy was presented and other management strategies such as medical treatment and laparotomy have been reviewed. PMID:24591909

Günenç, Ziya; Bingöl, Banu; Çelik, Aygen; Bozkurt, Serpil; Özekici, Ümit

2010-01-01

445

Interstitially implanted I125 for prostate cancer using transrectal ultrasound  

SciTech Connect

Prostate cancer is the third leading cause of death from cancer among men in the United States. Traditional treatments for prostate cancer are prostatectomy, external beam irradiation, and interstitial implantation of Iodine125 (I125) via laparotomy. These treatments are associated with significant morbidity and limitations. Based on experience with I125 interstitial implantation by transrectal ultrasound guidance for early-stage prostate cancer, it seems that this newer method of treatment has greater accuracy of placement and distribution of the isotope and has had few reported complications. The need for a surgical incision has been eliminated. Hospitalization time also has been decreased, creating the need for ambulatory and inpatient nurses to understand the importance of their respective roles in providing coordinated quality care for these patients. Nurses in these departments must have knowledge of the procedure, radiation safety, and common side effects related to the implant.

Greenburg, S.; Petersen, J.; Hansen-Peters, I.; Baylinson, W. (Northwest Tumor Institute, Seattle, WA (USA))

1990-11-01

446

DFT STUDY REVISES INTERSTITIAL CONFIGURATIONS IN HCP Zr  

SciTech Connect

Analysis of experimental result on microstructure evolution in irradiated Zr and alloys has demonstrated that available knowledge on self-interstitial defects in Zr is in contradiction. We therefore have initiated an extensive theoretical and modeling program to clarify this issue. In this report we present first ab initio calculations results of single SIA configurations in Zr. We demonstrate importance of simulations cell size, applied exchange-correlation functional and simulated c/a ratio. The results obtained demonstrate clearly that the most stable configurations are in basal plane and provide some evidences for enhanced interstitial transport along basal planes. The results obtained will be used in generation a new interatomic potential for Zr to be used in large-scale atomistic modeling of mechanisms relevant for radiation-induced microstructure evolution.

Samolyuk, German D [ORNL; Golubov, Stanislav I [ORNL; Osetskiy, Yury N [ORNL; Stoller, Roger E [ORNL

2012-06-01

447

Observation of interstitial molecular hydrogen in clathrate hydrates.  

PubMed

The current knowledge and description of guest molecules within clathrate hydrates only accounts for occupancy within regular polyhedral water cages. Experimental measurements and simulations, examining the tert-butylamine + H2 + H2O hydrate system, now suggest that H2 can also be incorporated within hydrate crystal structures by occupying interstitial sites, that is, locations other than the interior of regular polyhedral water cages. Specifically, H2 is found within the shared heptagonal faces of the large (4(3)5(9)6(2)7(3)) cage and in cavities formed from the disruption of smaller (4(4)5(4)) water cages. The ability of H2 to occupy these interstitial sites and fluctuate position in the crystal lattice demonstrates the dynamic behavior of H2 in solids and reveals new insight into guest-guest and guest-host interactions in clathrate hydrates, with potential implications in increasing overall energy storage properties. PMID:25139731

Grim, R Gary; Barnes, Brian C; Lafond, Patrick G; Kockelmann, Winfred A; Keen, David A; Soper, Alan K; Hiratsuka, Masaki; Yasuoka, Kenji; Koh, Carolyn A; Sum, Amadeu K

2014-09-26

448

Lung Cancer and Interstitial Lung Diseases: A Systematic Review  

PubMed Central

Interstitial lung diseases (ILDs) represent a heterogeneous group of more than two hundred diseases of either known or unknown etiology with different pathogenesis and prognosis. Lung cancer, which is the major cause of cancer death in the developed countries, is mainly attributed to cigarette smoking and exposure to inhaled carcinogens. Different studies suggest a link between ILDs and lung cancer, through different pathogenetic mechanisms, such as inflammation, coagulation, dysregulated apoptosis, focal hypoxia, activation, and accumulation of myofibroblasts as well as extracellular matrix accumulation. This paper reviews current evidence on the association between lung cancer and interstitial lung diseases such as idiopathic pulmonary fibrosis, sarcoidosis, systemic sclerosis, dermatomyositis/polymyositis, rheumatoid arthritis, systemic lupus erythematosus, and pneumoconiosis. PMID:22900168

Archontogeorgis, Kostas; Steiropoulos, Paschalis; Tzouvelekis, Argyris; Nena, Evangelia; Bouros, Demosthenes

2012-01-01

449

Interstitial Cystitis: Characterization and Management of an Enigmatic Urologic Syndrome  

PubMed Central

The enigmatic urologic condition known as interstitial cystitis has an estimated prevalence of 0.01% to 0.50% of the female population. Its etiology is unknown but may involve microbiologic, immunologic, mucosal, neurogenic, and/or other, as yet undefined, agents. There is no gold standard for the diagnosis of interstitial cystitis; rather, it is a diagnosis of exclusion. It is impossible to provide a purely evidence-based treatment strategy, but review of available evidence suggests that conservative supportive therapy (including diet modification); oral treatment with pentosan polysulfate, amitriptyline, hydroxyzine, or cimetidine; and intravesical treatments with heparinoids, dimethyl sulfoxide, alkalized lidocaine, or bacille Calmette-Guérin may be effective in some patients. PMID:16985667

Nickel, J. Curtis

2002-01-01

450

Longitudinal alignment of disease progression in fibrosing interstitial lung disease.  

PubMed

Generating disease progression models from longitudinal medical imaging data is a challenging task due to the varying and often unknown state and speed of disease progression at the time of data acquisition, the limited number of scans and varying scanning intervals. We propose a method for temporally aligning imaging data from multiple patients driven by disease appearance. It aligns follow- up series of different patients in time, and creates a cross-sectional spatio-temporal disease pattern distribution model. Similarities in the disease distribution guide an optimization process, regularized by temporal rigidity and disease volume terms. We demonstrate the benefit of longitudinal alignment by classifying instances of different fibrosing interstitial lung diseases. Classification results (AUC) of Usual Interstitial Pneumonia (UIP) versus non-UIP improve from AUC = 0.71 to 0.78 following alignment, classification of UIP vs. Extrinsic Allergic Alveolitis (EAA) improves from 0.78 to 0.88. PMID:25485367

Vogl, Wolf-Dieter; Prosch, Helmut; Müller-Mang, Christina; Schmidt-Erfurth, Ursula; Langs, Georg

2014-01-01

451

Lung cancer and interstitial lung diseases: a systematic review.  

PubMed

Interstitial lung diseases (ILDs) represent a heterogeneous group of more than two hundred diseases of either known or unknown etiology with different pathogenesis and prognosis. Lung cancer, which is the major cause of cancer death in the developed countries, is mainly attributed to cigarette smoking and exposure to inhaled carcinogens. Different studies suggest a link between ILDs and lung cancer, through different pathogenetic mechanisms, such as inflammation, coagulation, dysregulated apoptosis, focal hypoxia, activation, and accumulation of myofibroblasts as well as extracellular matrix accumulation. This paper reviews current evidence on the association between lung cancer and interstitial lung diseases such as idiopathic pulmonary fibrosis, sarcoidosis, systemic sclerosis, dermatomyositis/polymyositis, rheumatoid arthritis, systemic lupus erythematosus, and pneumoconiosis. PMID:22900168

Archontogeorgis, Kostas; Steiropoulos, Paschalis; Tzouvelekis, Argyris; Nena, Evangelia; Bouros, Demosthenes

2012-01-01

452

Acute TubuloInterstitial Nephritis and Uveitis Syndrome (TINU Syndrome)  

Microsoft Academic Search

Acute renal failure due to tubulo-interstitial nephritis developed in a 15-year-old girl. The disease was accompanied by uveitis and an inflammatory syndrome, consisting of a markedly increased erythrocyte sedimentation rate and high serum gamma globulin levels. The nephropathy as well as the inflammatory syndrome subsided spontaneously. A topical antiphlogistic treatment healed the ocular disease, which has not relapsed so far.

P. Vanhaesebrouck; D. Carton; C. De Bel; M. Praet; W. Proesmans

1985-01-01

453

Use of ?1-microglobulin for diagnosing chronic interstitial nephropathy.  

PubMed

?1-Microglobulin (?1M) is a low molecular weight protein and has been best characterized for detecting acute lesions of proximal tubules (Bonventre in Contrib Nephrol 156:213-219, 2007). This study has tried to evaluate the use of ?1M for the differential diagnosis of chronic interstitial nephropathy. 145 patients were recruited [81 men and 64 women, mean age 61.8 ± 16.7 years, 64.8 % have an estimated glomerular filtration (GFR) <60 ml/min]. Urinary ?1M was evaluated using an immunonephelometric assay. 82 patients were diagnosed as having chronic interstitial nephritis (CIN), and 46 patients have been previously diagnosed of glomerulonephritis (GN). A group of hypertensive patients without renal disease was used as control (n = 17). Patients in GN group had the highest ?1M excretion (15.05 mg/24 h). When the ?1M/albuminuria rates were calculated, the CIN group had the highest rate (1.03 mg/mg) and the GN group had the lowest rate (0.04 mg/mg) (p < 0.001). When the ?1M/proteinuria rates were calculated, the results were rather similar. The AUC for CIN group was 0.785, and the one for GN group was 0.139. Patients with estimated GFR <60 ml/min showed a higher excretion of ?1M (18.75, 8.75-40.00 mg/24 h). Nevertheless, ?1M/albuminuria and ?1M/proteinuria rates were still higher in CIN patients with GFR ?60 ml/min. ?1M urinary excretion is increased in chronic interstitial nephropathy and glomerulonephritis as well as in patients with GFR <60 ml/min. The ?1M/albuminuria rate and the ?1M/proteinuria quotient are increased in chronic interstitial nephropathies but decreased in glomerular diseases. PMID:23793995

Robles, Nicolas R; Lopez-Gomez, Juan; Garcia-Pino, Guadalupe; Ferreira, Flavio; Alvarado, Raul; Sanchez-Casado, Emilio; Cubero, Juan J

2014-08-01

454

Measurement of 222Rn in soil concentrations in interstitial air  

Microsoft Academic Search

Measurements of 222Rn soil concentrations were made by inserting stainless-steel sampling tubes into the soil. The samples of the soil interstitial air were taken in to pre-evacuated 1 L glass flasks. The glass flasks are cylindrical and coated with a film of ZnS(Ag). 222Rn was measured by counting the alpha particles emitted by 222Rn and its daughter products, 218Po and

C Dueñas; M. C Fernández; J Carretero; E Liger

1996-01-01

455

Interstitial pneumonitis induced by bicalutamide given for prostate cancer  

Microsoft Academic Search

We describe interstitial pneumonitis induced by bicalutamide prescribed to treat prostate cancer. A 78-year-old man with severe\\u000a lower paralysis and a bladder\\/rectal disorder was referred to our hospital. Prostate-specific antigen was elevated to 1418 ng\\/mL\\u000a at that time and magnetic resonance imaging revealed multiple bone metastases. A rectal examination revealed hard nodules\\u000a in the bilateral lobes of the prostate. We diagnosed

Toshihiko Masago; Takeshi Watanabe; Ryosuke Nemoto; Kinya Motoda

456

Intercalation of molecular species into the interstitial sites of fullerene  

Microsoft Academic Search

Molecular species were found to diffuse readily into the octahedral interstitial sites of the fcc lattice of Cââ. The ¹³C NMR spectrum of Cââ under magic angle spinning (MAS) conditions consisted of a primary resonance at 143.7 ppm and a minor peak shifted 0.7 ppm downfield. The downfield shift obeys Curie's law and is attributed to the Fermi-contact interaction between

Roger A. Assink; James E. Schirber; Douglas A. Loy; Bruno Morosin; Gary A. Carlson

1992-01-01

457

[Diabetes mellitus and the use of syringes and needles].  

PubMed

Among the diseases that produce a great amount of garbage of health, the individuals bearers of diabetes insulino-dependent mellittus are important producers of solid garbage of health. The main objective of this study is to identify how the insulino-dependent diabetics do the discard of the syringes and needles used in their residences. The method of the research was the descriptive study. The researched population was constituted of 70 insulino-dependent individuals. The collection of data was accomplished through questionnaire, in the period of October of 2006 to March of 2007. Inside of the relevant results, in which 100% do not know what biological garbage is and 51.43% discard in the common garbage the needles and syringes and ignore the course of the garbage to the embankment, the importance is demonstrated by becoming aware and educating the population of the risks of this practice being fundamental for the environment. PMID:20027954

Tapia, Carmen Elisa Villalobos

2009-06-01

458

Needles of Pinus halepensis as Biomonitors of Bioaerosol Emissions  

PubMed Central

We propose using the surface of pine trees needles to biomonitor the bioaerosol emissions at a composting plant. Measurements were based on 16S rRNA gene copy numbers of Saccharopolyspora rectivirgula, a bioindicator of composting plant emissions. A sampling plan was established based on 29 samples around the emission source. The abundance of 16S rRNA gene copies of S. rectivirgula per gram of Pinus halepensis needles varied from 104 to 102 as a function of the distance. The signal reached the background level at distances around the composting plant ranging from 2 km to more than 5.4 km, depending on the local topography and average wind directions. From these values, the impacted area around the source of bioaerosols was mapped. PMID:25379901

Galès, Amandine; Latrille, Eric; Wéry, Nathalie; Steyer, Jean-Philippe; Godon, Jean-Jacques

2014-01-01

459

Hashimoto's thyroiditis: fine-needle aspirations of 50 asymptomatic cases.  

PubMed

The cytologic findings from 50 cases of asymptomatic Hashimoto's thyroiditis diagnosed by fine-needle aspiration are reviewed. All patients were referred for fine-needle aspiration by the same physician: 48 because of thyroid enlargement and the clinical suspicion of Hashimoto's thyroiditis, two because of a small thyroid nodule. Positive antimicrosomal (antithyroid peroxidase) and/or antithyroglobulin antibody titers (performed by the same laboratory using the same technique) were present in only 25 of 48 patients evaluated. Cytologic findings included a predominantly lymphocytic process in 92% of the cases and a predominantly oxyphilic (Askanazy/Hürthle) cell process in 8% of the cases. It is likely that all patients were in an early stage of the autoimmune process. Our data indicate that the incidence of Hashimoto's thyroiditis is considerably higher than when recognized only by serologic tests for antibodies. PMID:7813361

Poropatich, C; Marcus, D; Oertel, Y C

1994-01-01

460

An augmented reality haptic training simulator for spinal needle procedures.  

PubMed

This paper presents the prototype for an augmented reality haptic simulation system with potential for spinal needle insertion training. The proposed system is composed of a torso mannequin, a MicronTracker2 optical tracking system, a PHANToM haptic device, and a graphical user interface to provide visual feedback. The system allows users to perform simulated needle insertions on a physical mannequin overlaid with an augmented reality cutaway of patient anatomy. A tissue model based on a finite-element model provides force during the insertion. The system allows for training without the need for the presence of a trained clinician or access to live patients or cadavers. A pilot user study demonstrates the potential and functionality of the system. PMID:23269747

Sutherland, Colin; Hashtrudi-Zaad, Keyvan; Sellens, Rick; Abolmaesumi, Purang; Mousavi, Parvin

2013-11-01

461

Endoscopic ultrasound-guided fine-needle injection.  

PubMed

With the development of linear array echoendoscopes and the ability to perform endoscopic ultrasound (EUS)-guided fine-needle aspiration, the delivery of therapeutic agents with fine-needle injection (FNI) emerged. EUS-guided FNI is an attractive delivery system because of its minimal invasiveness and low complication rate. This approach is effective in performing celiac plexus neurolysis for pain relief in patients with pancreatic cancer. The most exciting area of interest involves the delivery of antitumor agents in patients with locally advanced cancer, such as cancer of the pancreas or esophagus. The involvement of EUS-guided FNI in tumor therapy adds a host of potential new applications that continue to swing the pendulum of EUS from a diagnostic to a therapeutic modality. PMID:15555959

Klapman, Jason B; Chang, Kenneth J

2005-01-01

462