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1

Hollow needle used to cut metal honeycomb structures  

NASA Technical Reports Server (NTRS)

Hollow needle tool cuts metal honeycomb structures without damaging adjacent material. The hollow needle combines an electrostatic discharge and a stream of oxygen at a common point to effect rapid, accurate metal cutting. The tool design can be varied to use the hollow needle principle for cutting a variety of shapes.

Gregg, E. A.

1966-01-01

2

Localisation and mobility of trace metal in silver fir needles.  

PubMed

Trace metals (TM: Co, Ni, Cu, Zn, Cd, and Pb) as well as Al, Mn, and Fe content was measured in needles of a remote silver fir stand in the south of France. TM localisation and behaviour in needles was evaluated by measuring total and internal content of needles of different ages. Measured concentrations fell within background values. Al, Fe, Co, and Pb were trapped in wax following atmospheric particulate deposition. Contrasting accumulation and migration behaviours of the different elements studied were observed. The wax contained less than 10% Mn, Al, Ni, Co, and Zn and 15-45% Fe, Cu, and Cd in the young needles. Lead was mostly located in the wax (50-80%), and this proportion decreased with needle age. Only the internal content of Pb and Fe increased significantly with needle age. Finally, due to atmospheric deposition accumulation, higher input fluxes of Fe, Cu, Cd, and Pb can be expected in forest soil. PMID:22221667

Gandois, L; Probst, A

2012-04-01

3

Needle-free interstitial fluid acquisition using a Lorentz-force actuated jet injector  

E-print Network

Interstitial fluid (ISF) provides information on a patient's health as it contains regulatory molecules that are correlated with disease-related processes. However, current ISF acquisition techniques can be slow, resulting ...

Chang, Jean H

2014-01-01

4

COMPARISON OF THE METHODS FOR COLLECTING INTERSTITIAL WATER FOR TRACE ORGANIC COMPOUNDS AND METAL ANALYSES  

EPA Science Inventory

Several common materials and methods used to collect interstitial water were evaluated to determine their effect on the accuracy and precision of measured concentrations of selected organic compounds and metals. e compared the concentration of pollutants in doses seawater before ...

5

METAL-COLLOID PARTITIONING IN ARTIFICIAL INTERSTITIAL WATERS OF MARINE SEDIMENTS: INFLUENCES OF SALINITY, PH AND COLLOIDAL ORGANIC CARBON CONCENTRATION  

EPA Science Inventory

For decades, heavy metals have been deposited into marine sediments as a result of anthropogenic activities. Depending on their bioavailability, these metals may represent a risk to benthic organisms. Dissolved interstitial water metal concentrations have been shown to be better ...

6

New examples of clusters, extended metal-metal bonding and interstitial derivatives  

SciTech Connect

Synthesis of many new compounds with unusual stoichiometries and with structures that exhibit strong metal-metal bonding has been achieved in the last 10 to 12 years in binary halides of the early transition metals. Such characteristics had previously been limited to metal octahedra in the well-known (Nb,Ta)/sub 6/X/sub 12//sup n+/ and (Mo,W)/sub 6/X/sub 8//sup m+/ halide clusters (6 to 12 and 6 to 8 types, respectively; X = Cl, Br, I). This new chemistry is found for highly reduced binary halides of the metals Sc, Y, La, Zr, Hf and some lanthanides. The metal-metal arrays in these may be classified as conventional 6 to 12 or 6 to 8 type clusters that have, in response to reduced X:M ratios, condensed by sharing metal-metal edges to form infinite chains or sheets of clusters. The structures and properties thus lie along the interface between metals and normal salts (1,2,3). The use of welded niobium or tantalum containers has been vital to these discoveries, most of the products being achieved in relatively long-term reactions at 600 to 1000/sup 0/C. Some of the compounds have been found to bind a variety of small nonmetals within the metal interstices while others are uniquely stabilized by such interstitial atoms. Structure and bonding correlations as well as valence photoelectron spectra and extended Hueckel calculations are discussed for some of these binary halides of gadolinium, scandium and zirconium.

Corbett, J.D.

1984-01-01

7

Trace-element analysis in biological fluids: evaluation of contamination in samples collected with metallic needles  

Microsoft Academic Search

The present study refers to the determination of trace elements in biological fluids, specially copper in cerebrospinal fluid (CSF) from animals and it assesses the possible contamination of the samples with copper originating from the systems (metallic needles) employed for their extraction from the animals. The results show that there is a significant incorporation of copper originating from the material

A Sánchez Misiego; R. M Garc??a-Moncó Carra; M. P Ambel Carracedo

2003-01-01

8

Giant-cell interstitial pneumonia and hard-metal pneumoconiosis. A clinicopathologic study of four cases and review of the literature  

Microsoft Academic Search

We report four cases of giant-cell interstitial pneumonia that occurred in association with exposure to hard metals. All patients presented with chronic interstitial lung disease and had open-lung biopsies that revealed marked interstitial fibrosis, cellular interstitial infiltrates, and prominent intraalveolar macrophages as well as giant cells displaying cellular cannibalism. We also review the literature to determine the sensitivity and specificity

N. P. Ohori; F. C. Sciurba; G. R. Owens; M. J. Hodgson; S. A. Yousem

1989-01-01

9

Metal-metal bonding and interstitials in reduced rare-earth metal halides  

Microsoft Academic Search

Exploratory research in recent years has shown the rare-earth elements in their highly reduced halides exhibit a remarkable ability to undergo cluster formation, some as isolated units and others as infinite chains or slabs containing double-metal layers. Only a few of the elements have been studied in any detail, principally scandium, yttrium and gadolinium. Many of these new compounds are

J. D. Corbett; D. S. Dudis; J. E. Ford; S. J. Hwu; G. Meyer; S. Wijeyesekera

1986-01-01

10

Medical thoracoscopic removal of a metal needle from the pleural space.  

PubMed

Medical thoracoscopy is an excellent diagnostic and therapeutic tool for management of pleural diseases. There have been case reports of removal of foreign bodies from pleural spaces with video-assisted thoracoscopic surgery under general anaesthesia by thoracic surgeons. We present a case of successful removal of an 8?cm long metal needle from the pleural space with single port medical semirigid thoracoscopy under local anaesthesia by a chest physician. Removal of a foreign body from the pleural space is one more indication for medical thoracoscopy, however, an experienced chest physician and proper case selection are very important for safety and a successful outcome of this procedure. PMID:25301430

Gupta, Richa; James, Prince; Thangakunam, Balamugesh; Christopher, Devasahayam Jesudas

2014-01-01

11

Chesapeake Bay earth science study: interstitial water chemistry-chemical zonation, tributaries study, and trace metals. Final report  

SciTech Connect

The sediments of the Chesapeake Bay constitute a large reservoir of chemical species derived from natural and anthropogenic sources. The behavior of these materials in the estuary is determined by the physiochemical sedimentary environments in which they are found. Three major environments are identified, from the interstitial water chemistry as Northern Bay, Middle Bay, and Southern Bay. The chemical sedimentary environments of five tributaries to the main Bay were sampled for interstitial water. The data indicate the concentration of the metals are greater than coastal seawater and river water, and comparable to concentrations found in municipal waste.

Hill, J.M.; Blakeslee, P.J.; Conkwright, R.D.; McKeon, G.

1982-11-01

12

EFFECTS OF DIVALENT METAL CHLORIDES ON RESPIRATION AND EXTRACTABLE ENZYMATIC ACTIVITIES OF DOUGLAS-FIR NEEDLE LITTER  

EPA Science Inventory

The rates of CO2 evolution from Douglas-fir (Pseudotsuga menziesii Franco) needle litter, following application of divalent metal (Hg, Cd, Pb, Ni, Zn, and Cu) chlorides at rates of 10, 100, and 1,000 microgram/g and Ca chloride at 7, 68, and 683 microgram/g were monitored at 2- t...

13

Interstitial Cystitis  

MedlinePLUS

MENU Return to Web version Interstitial Cystitis Overview What is interstitial cystitis? Interstitial cystitis is chronic inflammation of the bladder. People who have interstitial cystitis have a bladder wall ...

14

Giant cell interstitial pneumonia in a hard-metal worker. Cytologic, histologic and analytical electron microscopic investigation  

Microsoft Academic Search

A case of biopsy-proven giant cell interstitial pneumonia in a patient with occupational exposure to hard-metal dust is reported. Bronchial washings performed several days prior to open-lung biopsy yielded an almost exclusive population of nonpigmented alveolar macrophages and pleomorphic, phagocytic multinucleated giant cells. Microorganisms, viral inclusions in the giant cells, epithelioid histiocytes and well-formed granulomas were not seen. This cytologic

K. Tabatowski; V. L. Roggli; W. J. Fulkerson; R. L. Langley; T. Benning; W. W. Johnston

1988-01-01

15

The Detection of Cold Dust in Cassiopeia A: Evidence for the Formation of Metallic Needles in the Ejecta  

NASA Astrophysics Data System (ADS)

Ejecta from core-collapse supernovae contain a few solar masses of refractory elements and therefore can be the most important source of interstellar dust if these elements condense efficiently into solids. However, infrared observations of young supernova remnants, such as Cas A or Kepler, and observations of SN 1987A have detected only ~10-3 Msolar of hot dust in these objects. Recently, Dunne et al. obtained 450 and 850 ?m SCUBA images of Cas A and reported the detection of 2-4 Msolar of cold (18 K) dust in the remnant. Here we show that their interpretation of the observations faces serious difficulties. Their inferred dust mass ignores the effect of grain destruction by sputtering and is larger than the mass of refractory material in the ejecta of a 10-30 Msolar star. The cold dust model faces even more difficulties if the 170 ?m observations of the remnant are included in the analysis, which decreases the cold dust temperature to ~ 8 K and increases its mass to >~ 20 Msolar. We offer here a more plausible interpretation of their observation, in which the cold dust emission is generated by conducting needles in the ejecta. The needle properties are completely determined by the combined submillimeter and X-ray observations of the remnant. The needles are collisionally heated by the shocked gas. They are very efficient emitters at submillimeter wavelengths and, with a resistivity of a few ?? cm, can readily attain a temperature of 8 K. Taking the destruction of needles into account, a dust mass of only 10-4 to 10-3 Msolar is needed to account for the observed SCUBA emission. The needles consist of metallic whiskers with <~1% of embedded impurities, which may have condensed out of blobs of material that were expelled at high velocities from the inner metal-rich layers of the star in an asymmetric explosion. Conductive needles may also be the source of the cold dust emission detected by Morgan et al. in Kepler. When aligned in the magnetic field, needles may give rise to observable polarized emission. The detection of submillimeter polarization will therefore offer definitive proof for a needle origin for the cold dust emission. Supernovae may yet be proven to be important sources of interstellar dust, but the evidence is still inconclusive.

Dwek, Eli

2004-06-01

16

Conifer needles as biomonitors of atmospheric heavy metal deposition: comparison with mosses and precipitation, role of the canopy  

NASA Astrophysics Data System (ADS)

Concentrations of seven elements (As, Cd, Cr, Mn, Pb, V, Zn) in mosses ( Hylocomium splendens, Pleurozium schreberi, Eurhynchium angustirete) and needles of Norway spruce ( Picea abies) and juniper ( Juniperus communis) were determined at 48 sites in Lithuania. Conifer needles consistently showed many times lower concentrations than mosses collected at the same site. Correlations between heavy-metal concentrations in needles and mosses indicated that accumulation processes may be similar, but mosses appear to be clearly preferable as biomonitors of atmospheric deposition because of their higher elemental concentrations and more quantitative reflection of deposition rates. Precipitation in the open field and under the canopy was investigated at two stations with respect to the same metals. The canopy was shown to retain a considerable part of lead, whereas elements such as Zn and Mn were enriched in precipitation under the canopy. Study of metal concentrations in moss growing, respectively, below and outside the canopy showed that none of so studied elements was significantly retained by the canopy. Most of the metals (Cu, Fe, Zn, Cr, Ni, V) were leached from the canopy to a smaller or greater extent.

?eburnis, D.; Steinnes, E.

17

Interstitial cystitis  

MedlinePLUS

Cystitis - interstitial; IC ... bladder is almost full. If you have interstitial cystitis, the signal to empty your bladder is sent ... intercourse Many people who have long-term interstitial cystitis are also depressed because of the pain and ...

18

INTERACTION OF METALS AND ORGAINIC CARBON COLLOIDS IN ANOXIC INTERSTITIAL WATERS OF MARINE SEDIMENTS  

EPA Science Inventory

Marine colloids are an important component of natural water geochemistry critical to the cycling, speciation and bioavailability of metals in marine sediments. In sediment, metals exist in three phases: particulate, colloidal and dissolved. Dissolved metal concentrations have bee...

19

Contribution of ammonia, metals, and nonpolar organic compounds to the toxicity of sediment interstitial water from an Illinois River tributary  

SciTech Connect

Toxicity of Illinois River bulk sediment, sediment interstitial (pore) water and elutriates to the oligochaete Lumbriculus variegatus, fathead minnow (Pimephales promelas) and the amphipod Hyalella azteca was compared to determine the most representative aqueous fraction for toxicity identification evaluation (TIE) studies. Toxicity of pore water corresponded better than elutriates to bulk sediment toxicity. Subsequent TIE procedures conducted with the cladoceran Ceriodaphnia dubia indicated that ammonia, metals and nonpolar organic compounds (nonylphenols, polycyclic aromatic hydrocarbons, benzenes, long-chain hydrocarbons) were responsible for toxicity of the sediment pore water. Results of TIE manipulations also suggested that methods for recovering pore water that include filtration may eliminate, a priori, a major component of the sediment contaminants responsible for toxicity.

Schubauer-Berigan, M.K.; Ankley, G.T.

1991-01-01

20

ROLE OF ACID-VOLATILE SULFIDE AND INTERSTITIAL WATER METAL CONCENTRATIONS IN DETERMINING BIOAVAILABILITY OF CADMIUM AND NICKEL FROM CONTAMINATED SEDIMENTS TO THE MARINE POLYCHAETE NEANTHES ARENACEODENTATA  

EPA Science Inventory

This study investigated the influence of acid-volatile sulfide (AVS) and interstitial water (IW) metal concentrations on bioavailability and toxicity of Cd and Ni to an infaunal sediment-ingesting marine worm, Neanthes arenaceodentata. end exposures were conducted with sediments,...

21

Film and interstitial formation of metals in plasma-sprayed ceramics  

NASA Technical Reports Server (NTRS)

A method is described to electrodeposit noble metals such as platinum and ordinary metals such as copper on and within plasma-sprayed ceramic materials and ceramic fiber materials. Low-density ceramic fiber bodies were vacuum impregnated with plating solution and attached to an electrode. Light micrographs illustrating the density and location of deposited materials are presented and discussed. Voids in the plasma-sprayed ceramic were filled with deposits that vary from spherical to lens-shaped circular and have particle size corresponding to the full range of void size. Multiple coatings of ceramic and metal can be sequenced.

Hendricks, R. C.; Mcdonald, G.; Mullen, R. L.

1985-01-01

22

The role of acid-volatile sulfide and interstitial water metal concentrations in determining bioavailability of cadmium and nickel from contaminated sediments to the marine polychaete Neanthes arenaceodentata  

SciTech Connect

This study investigated the influence of acid-volatile sulfide (AVS) and interstitial water (IW) metal concentrations on bioavailability and toxicity of Cd and Ni to an infaunal sediment-ingesting marine worm, Neanthes Arenaceodentata. Ten-d exposures were conducted with sediments, contaminated primarily with Cd and Ni, from Foundry Cove (Hudson River, NY), and with uncontaminated sediments spiked with Cd or Ni. Molar ratios of simultaneously extracted metal (SEM)/AVS ranged from < 0.02 to 44 for Cd-spiked, 0.02 to 241 for Ni-spiked, and <0.06 to 125 for Foundry Cove sediments. In all experiments, significant mortality was not observed when SEM/AVS ratios were <1.0 and interstitial water toxic units (IWTU) were <1.0. In the Cd and Ni-spiked experiments, when SEM/AVS ratios or IWTUs were >1.0, sediments were either lethal or worms did not burrow. Mortality of worms in Foundry Cove sediments was [le] 20%, and worms burrowed in all these sediments. However, IW contained <1.0 TU (Ni + Cd) in all Foundry Cove sediments except one (IWTU = 1.69). Metal concentrations in worms generally increased with increases in sediment metal concentration, SEM/AVS molar ratio, and IW metal concentration. The presence of metal in worms from sediments from SEM/AVS ratios <1.0 may be evidence of release of Cd or Ni from oxidized metal sulfide (a result of burrowing), uptake of metal from ingested sediment, or adsorption to body surfaces. These results support the hypothesis that when the concentration of AVS in sediments exceeds that of divalent metals sediments will not be acutely toxic. However, a greater number of sediments was correctly predicted to be nontoxic when interstitial water metal concentration of <1.0 TU was used.

Pesch, C.E.; Hansen, D.J.; Boothman, W.S. (Environmental Protection Agency, Narragansett, RI (United States). Environmental Research Lab.); Berry, W.J. (Science Applications International Corp., Narragansett, RI (United States)); Mahony, J.D. (Manhattan Coll., Bronx, NY (United States). Chemistry Dept.)

1995-01-01

23

Unstable interstitial-vacancy pairs and paradoxes of high temperature properties of metals  

Microsoft Academic Search

There are some quite general and quite unexpected features of the high temperature behaviour of metals being reviewed by Ya.\\u000a Kraftmakher. These are the discrepancy between the estimated number of point defects, determined by equilibrium and quenching\\u000a experiments, the discrepancy between a number of point defects, estimated by high temperature dilatometric measurements and\\u000a heat capacity ones, as well as the

Vladimir M. Koshkin

1999-01-01

24

Shock compression of interstitial oxygen in vanadium: Universal compression behavior of oxygen in metallic environments  

NASA Astrophysics Data System (ADS)

Shock-compression experiments were performed on V-O alloys (VO0.10, VO0.18, VO0.28) to 130 GPa using a propellant gun and a two-stage light-gas gun. Approximately linear relations were found for the shock velocity and particle velocity for the three alloys. Comparison of the pressure dependence of the oxygen-induced volume in the V-O alloys with reported data on elemental oxygen leads us to envisage a universal compression curve of oxygen atoms placed in metallic environments.

Nitta, Masaki; Iino, Satoru; Fukai, Yuh; Fukuoka, Kiyoto; Syono, Yasuhiko

1998-10-01

25

Buffon's Needle  

NSDL National Science Digital Library

An investigation of the problem: Consider a plane, ruled with equidistant parallel lines, where the distance between the lines is D. A needle of length L is tossed onto the plane. What is the probability that the needle intersects one or more lines?

2007-08-01

26

Mn 5Si 3-type host-interstitial boron rare-earth metal silicide compounds RE5Si 3: Crystal structures, physical properties and theoretical considerations  

NASA Astrophysics Data System (ADS)

A series of binary rare-earth metal silicides RE5Si 3 and ternary boron-interstitial phases RE5Si 3B x ( RE=Gd, Dy, Ho, Lu, and Y) adopting the Mn 5Si 3-type structure, have been prepared from the elemental components by arc melting. Boron "stuffed" phases were subsequently heated at 1750 K within a high-frequency furnace. Crystal structures were determined for both binary and ternary series of compounds from single-crystal X-ray data: hexagonal symmetry, space group P6 3/ mcm, Z=2. Boron insertion in the host binary silicides results in a very small decrease of the unit cell parameters with respect to those of the binaries. According to X-ray data, partial or nearly full boron occupancy of the interstitial octahedral sites in the range 0.6-1 is found. The magnetic properties of these compounds were characterized by the onset of magnetic ordering below 100 K. Boron insertion induces a modification of the transition temperature and ?p values in most of the antiferromagnetic binary silicides, with the exception of the ternary phase Er 5Si 3B x which was found to undergo a ferromagnetic transition at 14 K. The electrical resistivities for all binary silicides and ternary boron-interstitial phases resemble the temperature dependence of metals, with characteristic changes of slope in the resistivity curves due to the reduced electron scattering in the magnetically ordered states. Zintl-Klemm concept would predict a limiting composition RE5Si 3B 0.6 for a valence compound and should then preclude the stoichiometric formula RE 5Si 3B. Density functional theory calculations carried out on some RE5Si 3Z x systems for different interstitial heteroatoms Z and different x contents from 0 to 1 give some support to this statement.

Roger, Jérome; Ben Yahia, Mouna; Babizhetskyy, Volodymyr; Bauer, Joseph; Cordier, Stéphane; Guérin, Roland; Hiebl, Kurt; Rocquefelte, Xavier; Saillard, Jean-Yves; Halet, Jean-François

2006-08-01

27

Interstitial Cystitis  

Microsoft Academic Search

Interstitial cystitis (IC) is a chronic pelvic pain syndrome. The key symptoms are urinary urgency, frequency, pelvic pain,\\u000a bowel dysfunction, and vaginal pain in the abscence of other identifiable causes such as urinary tract infection, bladder\\u000a cancer, or endometriosis. Treatment should be multifocal, not directed solely toward the bladder, and multimodal encompassing\\u000a stress reduction, psychological support, dietary\\/behavioral therapy, pelvic floor

Kenneth M. Peters; Donna Carrico

28

VOLUME 80, NUMBER 19 P H Y S I C A L R E V I E W L E T T E R S 11 MAY 1998 Role of Self-Interstitial Atoms on the High Temperature Properties of Metals  

E-print Network

, is usually paid to the other point defect, the self-interstitial atom. The high mobility of this de- fect-Interstitial Atoms on the High Temperature Properties of Metals K. Nordlund* and R. S. Averback Materials Research.70.Dv It is well known that vacancies are the predominant point defect in metals at elevated

Nordlund, Kai

29

Childhood Interstitial Lung Disease  

MedlinePLUS

... page from the NHLBI on Twitter. What Is Childhood Interstitial Lung Disease? Childhood interstitial (in-ter-STISH-al) lung disease, or ... doctors better understand these diseases. Rate This Content: Childhood Interstitial Lung Disease Clinical Trials Clinical trials are ...

30

Interstitial Lung Disease  

MedlinePLUS

... MS Dept. of Medicine View full profile Interstitial Lung Disease (ILD): Overview Interstitial lung disease (ILD) is a ... they may make informed decisions Learn more. Interstitial Lung Disease Program As a center specializing in the care ...

31

Past, present, and future for surgical needles and needle holders.  

PubMed

During the last two decades, major advances in surgical needle and needle holder technology have markedly improved surgical wound repair. These advances include quantitative tests for surgical needle and needle holders performance, high nickel maraging stainless steels, compound curved needles, needle sharpening methods, laser-drilled holes for swages, needle:suture ratios of 1:1, and the atraumatic needle holder. PMID:8238747

Edlich, R F; Thacker, J G; McGregor, W; Rodeheaver, G T

1993-11-01

32

New interstitial HDR brachytherapy technique for prostate cancer: CT based 3D planning after transrectal implantation  

Microsoft Academic Search

We have developed a new interstitial HDR brachytherapy technique for the treatment of prostate cancer using CT based 3D planning after transrectal implantation of four non-parallel needles. CT based needle reconstruction, target definition, evaluation and documentation, including DVHs and 3D imaging, is a feasible, safe and well tolerated treatment concept.

Thomas Martin; Christos Kolotas; Thomas Dannenberg; Gerd Strassmann; Hans-Georg Vogt; Reinhard Heyd; Bernd Rogge; Dimos Baltas; Ralf Kurek; Ulf Tunn; Nikolaos Zamboglou

1999-01-01

33

Vibrational modes and diffusion of self-interstitial atoms in body-centered-cubic transition metals: A tight-binding molecular-dynamics study  

NASA Astrophysics Data System (ADS)

Using a tight-binding molecular-dynamics method, we have calculated the formation energies, diffusivity, and localized vibrational frequencies of self-interstitial atoms (SIA’s) in body-centered-cubic (bcc) transition metals: vanadium, niobium, molybdenum, and tantalum. As a test of our methods, we compare to experiment for the perfect bcc phonon spectra and we compare to previous ab initio SIA formation energies. In addition, we present vibrational spectra calculated from molecular dynamics via the velocity autocorrelation method. For all of the systems studied, we find that the localized vibration frequency of a SIA dumbbell pair is roughly twice the frequency of the bcc phonon-density-of-states peak. We also find an Arrhenius temperature dependence for SIA hopping, with frequency prefactors ranging between the cutoff of the ideal bcc lattice and the highest frequencies of the SIA dumbbell. In all cases, we find that the energy barrier to SIA diffusion is approximately 0.1eV .

Finkenstadt, Daniel; Bernstein, N.; Feldman, J. L.; Mehl, M. J.; Papaconstantopoulos, D. A.

2006-11-01

34

Interstitial Lung Diseases  

MedlinePLUS

Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. The inflammation ... air is responsible for some types of interstitial lung diseases. Specific types include Black lung disease among coal ...

35

Interstitial granulomatous dermatitis  

E-print Network

interstitial granulomatous dermatitis with arthritis includes granuloma annulare, urticarial vasculitis, erythema chronicum migrans (Lyme borreliosis), rheumatoid neutrophilic dermatosis, mycosis fungoides (

Johnson, Hillary; Mengden, Stephanie; Brancaccio, Ronald R

2008-01-01

36

The Biological Safety of Stainless Steel Needles Used in Warm-needling  

PubMed Central

Warm-needling (also called thermo-acupuncture) is a combination of acupuncture and moxibustion. Due to the intense heat involved, there have been concerns over the biological safety of the acuneedles used in the treatment. This paper reports two phases of a safety test. For a preliminary test, we compared the temperature change patterns of stainless steel (SS304) needles and traditional gold alloy needles, which have been increasingly replaced by the former. To verify the effects of the presence of coating materials, the main test involved three different kinds of SS304: silicone-coated, salicylic acid-coated and non-coated needles. Each group of needles was tested for pH level, heavy metals and UV absorbance spectrum along with biological tests on the cytotoxicity and hemolysis of the needle. All the tests on the extractants from the needles were negative. In the biological tests, each test result showed a significant difference from the positive control samples, while no significant difference was observed compared with the negative control samples. In the hemolysis tests, all samples satisfied the Korean Government Standards. All the results suggest that SS304 needles are biologically safe to be used in warm-needling, though they can be improved to perform as well as the gold alloy needles in terms of temperature fluctuations. PMID:19098297

Lee, Seunghun; Yi, Seung-Ho; Son, Yang-Sun; Choi, Sung-min; Kim, Young-Kon

2010-01-01

37

The Biological Safety of Stainless Steel Needles Used in Warm-needling.  

PubMed

Warm-needling (also called thermo-acupuncture) is a combination of acupuncture and moxibustion. Due to the intense heat involved, there have been concerns over the biological safety of the acuneedles used in the treatment. This paper reports two phases of a safety test. For a preliminary test, we compared the temperature change patterns of stainless steel (SS304) needles and traditional gold alloy needles, which have been increasingly replaced by the former. To verify the effects of the presence of coating materials, the main test involved three different kinds of SS304: silicone-coated, salicylic acid-coated and non-coated needles. Each group of needles was tested for pH level, heavy metals and UV absorbance spectrum along with biological tests on the cytotoxicity and hemolysis of the needle. All the tests on the extractants from the needles were negative. In the biological tests, each test result showed a significant difference from the positive control samples, while no significant difference was observed compared with the negative control samples. In the hemolysis tests, all samples satisfied the Korean Government Standards. All the results suggest that SS304 needles are biologically safe to be used in warm-needling, though they can be improved to perform as well as the gold alloy needles in terms of temperature fluctuations. PMID:19098297

Lim, Sabina; Lee, Seunghun; Yi, Seung-Ho; Son, Yang-Sun; Choi, Sung-Min; Kim, Young-Kon

2010-06-01

38

Immunization without needles  

Microsoft Academic Search

Most current immunization procedures make use of needles and syringes for vaccine administration. With the increase in the number of immunizations that children around the world routinely receive, health organizations are beginning to look for safer alternatives that reduce the risk of cross-contamination that arises from needle reuse. This article focuses on contemporary developments in needle-free methods of immunization, such

Samir Mitragotri

2005-01-01

39

Optical dosimetry for interstitial photodynamic therapy  

SciTech Connect

An approach to photodynamic treatment of tumors is the interstitial implantation of fiber optic light sources. Dosimetry is critical in identifying regions of low light intensity in the tumor which may prevent tumor cure. We describe a numerical technique for calculating light distributions within tumors, from multiple fiber optic sources. The method was tested using four translucent plastic needles, which were placed in a 0.94 X 0.94 cm grid pattern within excised Dunning R3327-AT rat prostate tumors. A cylindrical diffusing fiber tip, illuminated by 630 nm dye laser light was placed within one needle and a miniature light detector was placed within another. The average penetration depth in the tumor region between the two needles was calculated from the optical power measured by the detector, using a modified diffusion theory. Repeating the procedure for each pair of needles revealed significant variations in penetration depth within individual tumors. Average values of penetration depth, absorption coefficient, scattering coefficient, and mean scattering cosine were 0.282 cm, 0.469 cm-1, 250 cm-1 and 0.964, respectively. Calculated light distributions from four cylindrical sources in tumors gave reasonable agreement with direct light measurements using fiber optic probes.

Arnfield, M.R.; Tulip, J.; Chetner, M.; McPhee, M.S. (Cross Cancer Institute, Edmonton, Alberta (Canada))

1989-07-01

40

Needle-like apatite-leucite glass-ceramic as a base material for the veneering of metal restorations in dentistry  

Microsoft Academic Search

A needle-like apatite-leucite glass-ceramic was prepared in the SiO2-Al2O3-Na2O-K2O-P2O5-F system. Nucleation and crystallization processes were studied in bulk and powdered samples. The crystallization of leucite follows the mechanism of surface crystallization. After the precipitation of NaCaPO4 crystals and another unknown crystal phase, the formation of needle-like apatite is based on a volume nucleation and crystallization process. The mechanism of the

V. Rheinberger; S. Wegner; M. Frank

2000-01-01

41

Examination of surface conditions and other physical properties of commonly used stainless steel acupuncture needles  

PubMed Central

Objectives The present work examined the surface conditions and various other physical properties of sterilised single-use stainless steel acupuncture needles from two of the most popular brands widely used in many countries. Methods Scanning electron microscope (SEM) images were taken for 10 randomly chosen needles from each brand. Further SEM images were taken after each of these needles underwent a standard manipulation with an acupuncture needling practice gel. A comparison of forces and torques during the needling process was also carried out. Results The SEM images revealed significant surface irregularities and inconsistencies at the needle tips, especially for needles from one of the two brands. Metallic lumps and small, loosely attached pieces of material were observed on the surfaces of some needles. Some of the lumps and pieces of material seen on the needle surfaces disappeared after the acupuncture manipulation. If these needles had been used on patients, the metallic lumps and small pieces of material could have been deposited in human tissues, which could have caused adverse events such as dermatitis. Malformed needle tips might also cause other adverse effects including bleeding, haematoma/bruising, or strong pain during needling. An off-centre needle tip could result in the needle altering its direction during insertion and consequently failing to reach the intended acupuncture point or damaging adjacent tissues. Conclusions These findings highlight the need for improved quality control of acupuncture needles, with a view to further enhancing the safety and comfort of acupuncture users. PMID:24522003

Xie, Yi Min; Xu, Shanqing; Zhang, Claire Shuiqing; Xue, Charlie Changli

2014-01-01

42

Needle Biopsy of the Lung  

MedlinePLUS

Needle Biopsy of the Lung • Overview A lung nodule is relatively round lesion, or area of abnormal tissue located ... is benign (non-cancerous) or cancerous. A needle biopsy, also called a needle aspiration , involves removing some ...

43

Magnetism driven by non-metal interstitials from first-principles prediction: The case of hydrogen- and fluorine-doped calcium monoxide with rock-salt structure  

NASA Astrophysics Data System (ADS)

Our first-principles calculations based on density functional theory confirmed the formation of sp-ferromagnetic states of calcium monoxide with interstitial nonmagnetic F or H atoms. The hydrogen and fluorine interstitials in the oxides were found to be spin polarized and are more stable in the antiferromagnetic state and the ferromagnetic state, respectively. For H-doped CaO, no considerable charge transfer takes place and the spin remains localized on the impurity. For F-doped oxide, the observation may be attributed to the p-p interaction and the charge transfer between the interstitial atom and the neighboring O atoms. We demonstrate that H-doped compound is a potential n-type antiferromagnet, while F-doped material is a potential p-type ferromagnet. The different dopants would induce different magnetic couplings, thus show different ground-state magnetic configurations. The mechanism for the magnetism should be useful for understanding d0 magnetic semiconductors or insulators. The present potential d0 diluted magnetic materials, at least some of them, may be useful in spintronics.

Dong, Shengjie; Zhao, Hui

2014-12-01

44

Intracranial interstitial radiation  

SciTech Connect

Primary malignant brain tumors are fatal, with 90% of patients having these tumors dying within two years following diagnosis. Cranial interstitial radiation therapy, a technique under investigation to control these tumors, involves implantation of radioactive iodine 125 seeds into the tumor bed by stereotaxic technique. The interstitial radiation technique, monitoring of radiation, and nursing care of patients are discussed. Case histories are presented, along with discussion of results attained using this therapy, and its future.

Willis, D.; Rittenmeyer, H.; Hitchon, P.

1986-06-01

45

Interstitial granulomatous dermatitis.  

PubMed

A 59-year-old woman with arthritis presented to the Skin Institute of New York with a 2-month history of asymptomatic, small, skin-colored papules that erupted symmetrically on the chest, back, and proximal extremities. Histopathologic examination of a biopsy specimen showed findings of interstitial granulomatous dermatitis. Clinical correlation suggested a diagnosis of interstitial granulomatous dermatitis with arthritis. No change in the lesions resulted from application of clobetasol 0.05 percent ointment to the affected areas. PMID:18627754

Johnson, Hillary; Mengden, Stephanie; Brancaccio, Ronald R

2008-01-01

46

Mn{sub 5}Si{sub 3}-type host-interstitial boron rare-earth metal silicide compounds RE {sub 5}Si{sub 3}: Crystal structures, physical properties and theoretical considerations  

SciTech Connect

A series of binary rare-earth metal silicides RE {sub 5}Si{sub 3} and ternary boron-interstitial phases RE {sub 5}Si{sub 3}B {sub x} (RE=Gd, Dy, Ho, Lu, and Y) adopting the Mn{sub 5}Si{sub 3}-type structure, have been prepared from the elemental components by arc melting. Boron 'stuffed' phases were subsequently heated at 1750 K within a high-frequency furnace. Crystal structures were determined for both binary and ternary series of compounds from single-crystal X-ray data: hexagonal symmetry, space group P6{sub 3}/mcm, Z=2. Boron insertion in the host binary silicides results in a very small decrease of the unit cell parameters with respect to those of the binaries. According to X-ray data, partial or nearly full boron occupancy of the interstitial octahedral sites in the range 0.6-1 is found. The magnetic properties of these compounds were characterized by the onset of magnetic ordering below 100 K. Boron insertion induces a modification of the transition temperature and {theta} {sub p} values in most of the antiferromagnetic binary silicides, with the exception of the ternary phase Er{sub 5}Si{sub 3}B {sub x} which was found to undergo a ferromagnetic transition at 14 K. The electrical resistivities for all binary silicides and ternary boron-interstitial phases resemble the temperature dependence of metals, with characteristic changes of slope in the resistivity curves due to the reduced electron scattering in the magnetically ordered states. Zintl-Klemm concept would predict a limiting composition RE {sub 5}Si{sub 3}B{sub 0.6} for a valence compound and should then preclude the stoichiometric formula RE{sub 5}Si{sub 3}B. Density functional theory calculations carried out on some RE {sub 5}Si{sub 3}Z {sub x} systems for different interstitial heteroatoms Z and different x contents from 0 to 1 give some support to this statement. - Graphical abstract: Incorporation of boron in vacant octahedral sites of the Mn{sub 5}Si{sub 3}-type phase Gd{sub 5}Si{sub 3} modifies its resistivity properties.

Roger, Jerome [Sciences Chimiques de Rennes, UMR 6226 CNRS-Universite de Rennes 1, Avenue du General Leclerc, F-35042 Rennes cedex (France); Ben Yahia, Mouna [Sciences Chimiques de Rennes, UMR 6226 CNRS-Universite de Rennes 1, Avenue du General Leclerc, F-35042 Rennes cedex (France); Babizhetskyy, Volodymyr [Sciences Chimiques de Rennes, UMR 6226 CNRS-Universite de Rennes 1, Avenue du General Leclerc, F-35042 Rennes cedex (France); Max-Planck-Institute fuer Festkoerperforschung, Heisenbergstrasse 1, Postfach 800665, D-70569 Stuttgart (Germany); Bauer, Joseph [Sciences Chimiques de Rennes, UMR 6226 CNRS-Universite de Rennes 1, Avenue du General Leclerc, F-35042 Rennes cedex (France); Cordier, Stephane [Sciences Chimiques de Rennes, UMR 6226 CNRS-Universite de Rennes 1, Avenue du General Leclerc, F-35042 Rennes cedex (France); Guerin, Roland [Sciences Chimiques de Rennes, UMR 6226 CNRS-Universite de Rennes 1, Avenue du General Leclerc, F-35042 Rennes cedex (France); Hiebl, Kurt [Innovative Materials Group, Universitaet Wien, Waehringerstrasse 42, A-1090 Wien (Austria)]. E-mail: Kurt.Hiebl@univie.ac.at; Rocquefelte, Xavier [Sciences Chimiques de Rennes, UMR 6226 CNRS-Universite de Rennes 1, Avenue du General Leclerc, F-35042 Rennes cedex (France); Institut des Materiaux Jean Rouxel, Laboratoire de Chimie des Solides, 2 rue de la Houssiniere, BP 32229, F-44322 Nantes cedex 3 (France); Saillard, Jean-Yves [Sciences Chimiques de Rennes, UMR 6226 CNRS-Universite de Rennes 1, Avenue du General Leclerc, F-35042 Rennes cedex (France); Halet, Jean-Francois [Sciences Chimiques de Rennes, UMR 6226 CNRS-Universite de Rennes 1, Avenue du General Leclerc, F-35042 Rennes cedex (France)]. E-mail: halet@univ-rennes1.fr

2006-08-15

47

21 CFR 872.4730 - Dental injecting needle.  

Code of Federal Regulations, 2013 CFR

...injecting needle is a slender, hollow metal device with a sharp point intended to be attached to a syringe to inject local anesthetics and other drugs. (b) Classification. Class I (general controls). The device is exempt from the...

2013-04-01

48

21 CFR 872.4730 - Dental injecting needle.  

...injecting needle is a slender, hollow metal device with a sharp point intended to be attached to a syringe to inject local anesthetics and other drugs. (b) Classification. Class I (general controls). The device is exempt from the...

2014-04-01

49

Experiments with needle bearings  

NASA Technical Reports Server (NTRS)

Experiments and results are presented in testing needle bearings, especially in comparison with roller bearings. Reduction in coefficient of friction is discussed as well as experimental methods and recording devices.

Ferretti, Pericle

1933-01-01

50

Mechanics of needle-tissue interaction  

Microsoft Academic Search

When a needle is inserted into soft tissue, interac- tion forces are developed at the needle tip and along the needle shaft. The needle tip force is due to cutting of the tissue, and the force along the needle shaft is due to friction between needle and tissue. In this study, the friction force is determined for needles inserted into

Roy J. Roesthuis; Youri R. J. van Veen; Alex Jahya; Sarthak Misra

2011-01-01

51

Mechanics of needle-tissue interaction  

Microsoft Academic Search

When a needle is inserted into soft tissue, interaction forces are developed at the needle tip and along the needle shaft. The needle tip force is due to cutting of the tissue, and the force along the needle shaft is due to friction between needle and tissue. In this study, the friction force is determined for needles inserted into a

Roy J. Roesthuis; Youri R. J. van Veen; Alex Jahya; Sarthak Misra

2011-01-01

52

Interstitial Lung Disease (ILD): Treatment  

MedlinePLUS

... MS Dept. of Medicine View full profile Interstitial Lung Disease (ILD): Treatment Treatment for ILD is based upon ... they may make informed decisions Learn more. Interstitial Lung Disease Program As a center specializing in the care ...

53

Interstitial lung disease - adults - discharge  

MedlinePLUS

... your breathing problems that are caused by interstitial lung disease. This disease scars your lungs, which makes it ... Raghu G. Interstitial lung disease. In: Goldman L, Schafer AI. ... ed. Philadelphia, PA: Elsevier Saunders; 2011: chap 92. Selman M, ...

54

Evaluation of nonholonomic needle steering using a robotic needle driver  

NASA Astrophysics Data System (ADS)

Accurate needle placement is a common need in the medical environment. While the use of small diameter needles for clinical applications such as biopsy, anesthesia and cholangiography is preferred over the use of larger diameter needles, precision placement can often be challenging, particularly for needles with a bevel tip. This is due to deflection of the needle shaft caused by asymmetry of the needle tip. Factors such as the needle shaft material, bevel design, and properties of the tissue penetrated determine the nature and extent to which a needle bends. In recent years, several models have been developed to characterize the bending of the needle, which provides a method of determining the trajectory of the needle through tissue. This paper explores the use of a nonholonomic model to characterize needle bending while providing added capabilities of path planning, obstacle avoidance, and path correction for lung biopsy procedures. We used a ballistic gel media phantom and a robotic needle placement device to experimentally assess the accuracy of simulated needle paths based on the nonholonomic model. Two sets of experiments were conducted, one for a single bend profile of the needle and the second set of tests for double bending of the needle. The tests provided an average error between the simulated path and the actual path of 0.8 mm for the single bend profile and 0.9 mm for the double bend profile tests over a 110 mm long insertion distance. The maximum error was 7.4 mm and 6.9 mm for the single and double bend profile tests respectively. The nonholonomic model is therefore shown to provide a reasonable prediction of needle bending.

Wilson, Emmanuel; Ding, Jeinan; Carignan, Craig; Krishnan, Karthik; Avila, Rick; Turner, Wes; Stoianovici, Dan; Yankelevitz, David; Banovac, Filip; Cleary, Kevin

2010-02-01

55

The Missing Needles: A Smooth Extension of Buffon's Needle Problem.  

ERIC Educational Resources Information Center

Describes the "Buffon's Needle" problem, which is calculating the probability that a needle will cross one of two separated lines. Calculates the probability when the length of the needle is greater than the space of the two lines. Provides an analytic solution and the results of a computer simulation. (YP)

McGivney, Raymond J., Jr.; Pollino, Benedict

1989-01-01

56

Fine needle aspiration of the thyroid  

MedlinePLUS

Thyroid nodule fine needle aspirate biopsy; Biopsy - thyroid - skinny-needle; Skinny-needle thyroid biopsy ... under your shoulders and your neck extended. The biopsy site is cleaned. A thin needle is inserted ...

57

Interstitials on Si 113 surface.  

NASA Astrophysics Data System (ADS)

We study the energetics of a Si 113 reconstructed surface with respect to the interstitial concentration and perform dynamics simulations at high temperatures in a tight-binding representation. Recent experiments and first-principle calculations(J. Dabrowski et al.), Phys. Rev. Lett. 73, 1660 (1994). have shown that Si 113 surface is very stable due to incorporating subsurface interstitials. In addition, interstitials are known to condense on 113 plane in bulk Si, forming so called 113 defects.(J. Kim et al.), Phys. Rev. B 55, 16186 (1997) and references therein. We investigate (i) the role of interstitials in stabilizing the surface reconstruction; (ii) migration of interstitials at high temperatures; (iii) transition from (3× 2) to (3× 1) reconstruction; (iv) possible links between the subsurface interstitials on 113 surface and the extended 113 defects; and (v) the relative stability of interstitials on low index surfaces.

Trinkle, Dallas R.; Kim, Jeongnim; Wilkins, John W.

1998-03-01

58

[Desquamative interstitial pneumonia].  

PubMed

Authors describe a case of desquamative interstitial pneumonia in a seven month old boy. Initial manifestations were anorexia, feeding difficulties, retarded ponderal and progressive respiratory distress. Pathologic diagnosis was performed by open pulmonary biopsy. He was treated with steroids and followed a severe clinical course dying at 9 months of age. Etiopathogenesis, diagnosis and treatment as well as cases published in pediatric literature are reviewed. PMID:4091343

Moreno García, M J; López-Herce Cid, J; Rodríguez Sánchez, C; Alvarado Ortega, F; Carrasco, S; Ruza Tarrió, F

1985-11-15

59

NEEDLE TRADES, MATHEMATICS - I.  

ERIC Educational Resources Information Center

THE NEEDLE TRADES INDUSTRY CONSISTS OF THREE TYPES OF ESTABLISHMENTS -- THE REGULAR MANUFACTURERS, THE APPAREL JOBBERS, AND THE CONTRACTORS. THE FUNCTIONS INCLUDED COVER A WIDE SCOPE FROM BUYING OF RAW MATERIAL TO SELLING OF THE FINISHED APPAREL. THE PURPOSE OF THIS STUDY GUIDE IS TO FURNISH BASIC KNOWLEDGE IN MATHEMATICS AND DEVELOP SKILL IN…

COLICCHIO, ANTOINETTE J.

60

Needle ban vetoed.  

PubMed

An appropriations bill with seven provisions, one of which barred the District of Columbia from spending money on needle-exchange programs, was vetoed by President Clinton. He called it objectionable and disruptive to the District's preventions efforts. The bill previously passed the House by a slim margin. Republicans objected to a contentious provision of the bill dealing with medicinal marijuana. PMID:11367272

1999-10-15

61

Buffon's Needle--A Simulation.  

ERIC Educational Resources Information Center

This paper describes a computer simulation of Buffon's needle problem. The problem considers the probability that a needle will cross a line when the needle is thrown in a random way onto the parallel lines a certain distance apart. The paper provides the algorithm and computer program. (YP)

Hart, Derek; Roberts, Tony

1989-01-01

62

Nonholonomic Modeling of Needle Steering  

Microsoft Academic Search

As a flexible needle with a bevel tip is pushed through soft tissue, the asymmetry of the tip causes the needle to bend. We propose that, by using nonholonomic kinematics, control and path planning, an appropriately designed needle can be steered through tissue to reach a specified 3D target. Such steering capability will enhance targeting accuracy and markedly improve outcomes

Robert J. Webster; Noah J. Cowan; Gregory S. Chirikjian; Allison M. Okamura

2004-01-01

63

A theoretical analysis of interstitial hydrogen : pressure-composition-temperature, chemical potential, enthalpy and entropy  

E-print Network

We provide a first principles analysis of the physics and thermodynamics of interstitial hydrogen in metal. By utilizing recent advances in Density Functional Theory (DFT) to get state energies of the metal-hydrogen system, ...

Orondo, Peter Omondi

2012-01-01

64

Needle Micro-Coils for MRS  

Microsoft Academic Search

A process for batch fabrication of low-cost needle-shaped microcoils for magnetic resonance spectroscopy (MRS) is demonstrated. The conductors are embedded inside a cross-section designed to avoid the signal cancellation that can occur with a completely immersed coil. Conductors are fabricated on oxidised silicon substrates by electroplating metals inside a deep resist mould, and then capped with a thick layer of

R. R. A. Syms; M. M. Ahmad; I. R. Young; D. Gilderdale; D. J. Collins

2006-01-01

65

Interstitial granulomatous dermatitis with arthritis.  

PubMed

Interstitial granulomatous dermatitis with arthritis is an uncommon disorder. In its original description, the presence of linear inflammatory indurations on the lateral aspects of the trunk (the rope sign) in association with arthritis were considered the pathognomonic clinical features. Later cases presenting with plaques and papules have been reported. Herein we describe a case of interstitial granulomatous dermatitis with arthritis without the rope sign. The present case supports the idea that interstitial granulomatous dermatitis with arthritis may have variable clinical appearances. PMID:15257555

Altaykan, Asli; Erkin, Gül; Boztepe, Gonca; Gököz, Aytaç

2004-07-01

66

Interstitial Collagen Catabolism*  

PubMed Central

Interstitial collagen mechanical and biological properties are altered by proteases that catalyze the hydrolysis of the collagen triple-helical structure. Collagenolysis is critical in development and homeostasis but also contributes to numerous pathologies. Mammalian collagenolytic enzymes include matrix metalloproteinases, cathepsin K, and neutrophil elastase, and a variety of invertebrates and pathogens possess collagenolytic enzymes. Components of the mechanism of action for the collagenolytic enzyme MMP-1 have been defined experimentally, and insights into other collagenolytic mechanisms have been provided. Ancillary biomolecules may modulate the action of collagenolytic enzymes. PMID:23430258

Fields, Gregg B.

2013-01-01

67

Pneumoproteins in interstitial lung diseases.  

E-print Network

??The interstitial lung diseases (ILD)s are a diverse group of pulmonary disorders that are classified together because of similar clinical, roentgenographic, physiologic, or pathologic manifestations,… (more)

Janssen, Rob

2006-01-01

68

Subclinical Interstitial Lung Disease  

PubMed Central

The widespread use of high-resolution computed tomography in clinical and research settings has increased the detection of interstitial lung abnormalities (ILA) in asymptomatic and undiagnosed individuals. We reported that in smokers, ILA were present in about 1 of every 12 high-resolution computed tomographic scans; however, the long-term significance of these subclinical changes remains unclear. Studies in families affected with pulmonary fibrosis, smokers with chronic obstructive pulmonary disease, and patients with inflammatory lung disease have shown that asymptomatic and undiagnosed individuals with ILA have reductions in lung volume, functional limitations, increased pulmonary symptoms, histopathologic changes, and molecular profiles similar to those observed in patients with clinically significant interstitial lung disease (ILD). These findings suggest that, in select at-risk populations, ILA may represent early stages of pulmonary fibrosis or subclinical ILD. The growing interest surrounding this topic is motivated by our poor understanding of the inciting events and natural history of ILD, coupled with a lack of effective therapies. In this perspective, we outline past and current research focused on validating radiologic, physiological, and molecular methods to detect subclinical ILD. We discuss the limitations of the available cross-sectional studies and the need for future longitudinal studies to determine the prognostic and therapeutic implications of subclinical ILD in populations at risk of developing clinically significant ILD. PMID:22366047

Doyle, Tracy J.; Hunninghake, Gary M.

2012-01-01

69

Usual interstitial pneumonia.  

PubMed

Usual interstitial pneumonia (UIP) is a distinct histological lesion observed in idiopathic pulmonary fibrosis (IPF) but can be found in other etiologies. The diagnosis of UIP can be established by surgical lung biopsy or by high-resolution thin-section computed tomographic (CT) scans (provided the radiographic features are classical). Historically, patients labeled as "IPF" encompassed a group of disorders, including UIP as well as other idiopathic interstitial pneumonias that differ from UIP in prognosis and responsiveness to therapy. Current recommendations from international consensus statements restrict the term IPF to patients with idiopathic UIP. The inciting cause(s) and pathogenesis of UIP have not been elucidated, but alveolar epithelial cell injury and dysregulation or altered phenotypic expression of fibroblasts are key elements. Inflammatory cells may play minor roles in initiating or propagating the fibrotic process. The prognosis of UIP is poor. Mean survival following diagnosis approximates 3 years. Current therapies are of unproven value. Corticosteroids or immunosuppressive agents have been most often used, but data affirming benefit are lacking. Lung transplantation is a viable option for patients failing medical therapy. This review discusses diagnostic criteria for UIP (both histopathological and radiographic), natural history and clinical course, and therapeutic approaches (both current and future). PMID:17195140

Lynch, Joseph P; Saggar, Rajan; Weigt, S Sam; Zisman, David A; White, Eric S

2006-12-01

70

Occupational Interstitial Lung Disease Update  

Microsoft Academic Search

Overview Occupational exposures produce a wide range of interstitial lung disorders. Occupational etiologies account for a significant portion of all interstitial lung disease (ILD), and new causes continue to be described. All of these disorders are preventable with the reduction or elimination of workplace exposure. This chapter highlights the common, persistent diseases that continue to plague workers globally, as well

Lee S. Newman

71

Interstitial granulomatous dermatitis with plaques  

Microsoft Academic Search

Background: Interstitial granulomatous dermatitis is a histopathologic pattern with variable clinical appearance associated with autoimmune systemic diseases. The frequency of its different cutaneous expressions and its association with autoimmune diseases are not known. Objective: We describe the clinical, serologic, and histologic features in 17 patients with interstitial granulomatous dermatitis with a clinical presentation consisting of large erythematous plaques. Method: Skin

Carlo Tomasini; Mario Pippione

2002-01-01

72

Interstitial granulomatous dermatitis with arthritis  

Microsoft Academic Search

Background: Interstitial granulomatous dermatitis with arthritis is an uncommon systemic disorder involving the cutaneous and musculoskeletal systems. The eruption may mimic other dermatoses including granuloma annulare, erythema chronicum migrans, and the inflammatory stage of morphea. Key histopathologic characteristics, along with clinical correlation, allow accurate diagnosis.Objective: We describe the clinical, serologic, and histologic features in three patients with interstitial granulomatous dermatitis

David Long; Diane M Thiboutot; Joseph T Majeski; David B Vasily; Klaus F Helm

1996-01-01

73

Interstitial granulomatous dermatitis with arthritis  

Microsoft Academic Search

Interstitial granulomatous dermatitis with arthritis is an uncommon disorder. In its original description, the presence of linear inflammatory indurations on the lateral aspects of the trunk (the rope sign) in association with arthritis were considered the pathognomonic clinical features. Later cases presenting with plaques and papules have been reported. Herein we describe a case of interstitial granulomatous dermatitis with arthritis

Asli Altaykan; Gül Erkin; Gonca Boztepe; Aytaç Gököz

2004-01-01

74

Renal Medullary Interstitial Cells  

NASA Astrophysics Data System (ADS)

Renal medullary interstitial cells (RMICs) are specialized fibroblast-like cells that reside in the renal medulla among the vasa recta, the thin limbs of Henle's loop, and medullary collecting ducts. These cells are characterized by abundant lipid droplets in the cytoplasm. The lipid droplets are composed of triglycerides, cholesterol esters and free long-chain fatty acids, including arachidonic acid. RMICs are also a major site of cyclooxygenase2 (COX-2) expression, and thus a major site of COX-2 derived prostanoid biosynthesis. RMICs are also a potential target of hormones such as angiotensin II and endothelin. The RMIC COX-2 expression and the abundance of lipid droplets change with salt and water intake. These properties of RMICs are consistent with an important role of these cells in modulating physiologic and pathologic processes of the kidney.

Rao, Reena; Hao, Chuan-Ming; Breyer, Matthew D.

2007-04-01

75

Ban on needle swaps.  

PubMed

A District of Columbia appropriations bill banning spending for needle-exchange programs will be going to President Clinton for signature. The House voted to approve the bill, and the Senate voted to accept it. Politicians from both parties are lobbying the President about the bill. Clinton's budget director, Jacob J. Lew, and D.C. Del. Eleanor Holmes Norton, argue against signing the bill. Rep. Thomas M. Davis warns a veto would scuttle legislation that funds education reforms and cleanup of the Anacostia River. PMID:11367025

1999-10-01

76

Fine needle aspiration cytology.  

PubMed Central

Fine needle aspiration cytology is an inexpensive, atraumatic technique for the diagnosis of disease sites. This paper describes the technique and illustrates how it may be applied to the management of tumours throughout the body. The limitations of the method, the dangers of false positive reports, and the inevitability of false negative diagnoses are emphasised. In a clinical context the method has much to offer by saving patients from inappropriate operations and investigations and allowing surgeons to plan quickly and more rationally. It is an economically valuable technique and deserves greater recognition. Images PMID:2578481

Lever, J V; Trott, P A; Webb, A J

1985-01-01

77

Percutaneous needle nephrostomy  

PubMed Central

Percutaneous nephrostomy is a simple technique for temporary drainage of an obstructed kidney. Under local anaesthesia a ureteric catheter is passed through a Vim–Silverman needle into the renal pelvis and is connected to a drainage bag. Seven cases (six successful) in which this method was used are described and the indications are discussed. It has been free from complications, is acceptable to patients, and is felt to represent a useful addition to the methods available for the treatment of obstruction of the upper urinary tract. ImagesFig. 4Fig. 1Fig. 2 PMID:5359921

Ogg, C. S.; Saxton, H. M.; Cameron, J. S.

1969-01-01

78

21 CFR 882.1350 - Needle electrode.  

Code of Federal Regulations, 2010 CFR

... 2010-04-01 2010-04-01 false Needle electrode. 882.1350 Section 882.1350...Neurological Diagnostic Devices § 882.1350 Needle electrode. (a) Identification. A needle electrode is a device which is placed...

2010-04-01

79

21 CFR 880.5580 - Acupuncture needle.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 2010-04-01 false Acupuncture needle. 880.5580 Section 880.5580 Food...Therapeutic Devices § 880.5580 Acupuncture needle. (a) Identification. An acupuncture needle is a device intended to pierce the...

2010-04-01

80

Towards quantitative off-axis electron holographic mapping of the electric field around the tip of a sharp biased metallic needle  

NASA Astrophysics Data System (ADS)

We apply off-axis electron holography and Lorentz microscopy in the transmission electron microscope to map the electric field generated by a sharp biased metallic tip. A combination of experimental data and modelling provides quantitative information about the potential and the field around the tip. Close to the tip apex, we measure a maximum field intensity of 82 MV/m, corresponding to a field k factor of 2.5, in excellent agreement with theory. In order to verify the validity of the measurements, we use the inferred charge density distribution in the tip region to generate simulated phase maps and Fresnel (out-of-focus) images for comparison with experimental measurements. While the overall agreement is excellent, the simulations also highlight the presence of an unexpected astigmatic contribution to the intensity in a highly defocused Fresnel image, which is thought to result from the geometry of the applied field.

Beleggia, M.; Kasama, T.; Larson, D. J.; Kelly, T. F.; Dunin-Borkowski, R. E.; Pozzi, G.

2014-07-01

81

MEASURING INTERSTITIAL FLUID PRESSURE WITH FIBEROPTIC PRESSURE TRANSDUCERS  

PubMed Central

In this report we describe a practical procedure for measuring interstitial fluid pressure (IFP) using fiberoptic pressure transducers based on optical interferometry. Eight mice were used for subcutaneous IFP measurements and four mice for intramuscular IFP measurements with a FOBPS-18 fiberoptic pressure transducer. We used four mice for subcutaneous IFP measurements with a SAMBA-420 MR fiberoptic pressure transducer. One measurement was made for each mouse simultaneously by using a fiberoptic system and an established approach, either transducer-tipped catheter or wick-in-needle technique. The mean IFP values obtained in subcutaneous tissues were ?3.00 mm Hg (SEM ?/+?0.462, n=8), ?3.25 mmHg (SEM ?/+ 0.478, n=4), ?3.34mm Hg (SEM?/+ 0.312, n=6), and ?2.85 (SEM ?/+ 0.57, n= 6) for the FOBPS fiberoptic transducer, the SAMBA fiberoptic transducer, the transducer-tipped catheter, and the wick-in–needle technique, respectively. There was no difference between these techniques to measure IFP (Friedman test, p=0.7997). The subcutaneous IFP measurements showed strong linear correlation between fiberoptic transducer and transducer-tipped catheter (R2= 0.9950) and fiberoptic transducer and wick–in-needle technique (R2= 0.9966). Fiberoptic pressure transducers measure the interstitial fluid pressure accurately, comparable to conventional techniques. The simplified IFP measurement procedures described in this report will allow investigators to easily measure IFP, and elucidate the unit pressure change per unit volume change (dP/dV) in normal or cancer tissues in the presence of strong electromagnetic fields encountered in MRI. PMID:18809414

Ozerdem, Ugur

2008-01-01

82

Interstitial Cystitis / Painful Bladder Syndrome  

MedlinePLUS

... device companies, or patient support associations. The NIDDK’s investment in scientifically meritorious IC/PBS research across the ... Warren JW. Is interstitial cystitis an infectious disease? International Journal of Antimicrobial Agents. 2002;19(6):480- ...

83

Declining interstitial transsudation in man  

NASA Technical Reports Server (NTRS)

Results and methodology of experimentation dealing with declining interstitial transsudation are discussed. Concepts of the formation of interstitial fluids are in agreement with measurements of calf volume in normal young women, in horizontal recumbency or after horizontal immersion. The volume of the calf is reduced when the hydrostatic pressure of the blood column is diminished under the phlebostatic level and when the external pressure is increased by the hydrostatic pressure of a water bath.

Demarchin, P.; Lagneaux, D.; Lecomte, J.

1980-01-01

84

Percutaneous interstitial brachytherapy for adrenal metastasis: technical report  

PubMed Central

We developed and evaluated the feasibility of a brachytherapy technique as a safe and effective treatment for adrenal metastasis. Adapting a paravertebral insertion technique in radiofrequency ablation of adrenal tumors, we developed an interstitial brachytherapy for adrenal metastasis achievable on an outpatient basis. Under local anesthesia and under X-ray CT guidance, brachytherapy applicator needles were percutaneously inserted into the target. A treatment plan was created to eradicate the tumor while preserving normal organs including the spinal cord and kidney. We applied this interstitial brachytherapy technique to two patients: one who developed adrenal metastasis as the third recurrence of uterine cervical cancer after reirradiation, and one who developed metachronous multiple metastases from malignant melanoma. The whole procedure was completed in 2.5 hours. There were no procedure-related or radiation-related early/late complications. FDG PET-CT images at two and three months after treatment showed absence of FDG uptake, and no recurrence of the adrenal tumor was observed for over seven months until expiration, and for six months until the present, respectively. This interventional interstitial brachytherapy procedure may be useful as a safe and eradicative treatment for adrenal metastasis. PMID:22843376

Kishi, Kazushi; Tamura, Shinji; Mabuchi, Yasushi; Sonomura, Tetsuo; Noda, Yasutaka; Nakai, Motoki; Sato, Morio; Ino, Kazuhiko; Yamanaka, Noboru

2012-01-01

85

Radio-frequency current application in bipolar technique for interstitial thermotherapy (rf-ITT)  

NASA Astrophysics Data System (ADS)

For the interstitial treatment of pathologic tissue, e.g. tumors, the benign prostate hyperplasia or the concha hyperplasia in otorhinolaryngology, the method of interstitial laser photocoagulation and the monopolar RF- needle coagulation can be used as well as other methods, e.g. the microwave exposure, alcohol injection, ultrasound or hot water irrigation. This article will present latest results of interstitial thermotherapy with radio-frequency alternating current in bipolar technique. Therefore basic investigations of the thermal field distribution in in vitro samples were performed. THe efficiency of the developed applicators were examined using egg white and in in vitro experiments with porcine liver tissue. Bipolar needles with different diameters were built and tested. Carbonization and dehydration can be avoided by irrigation of the tissue during treatment through an integrated central flushing port. A bipolar needle has been developed for the treatment of concha hyperplasia which can be used as the monopolar pendant with similar results in partial tissue coagulation but without current flow in the sensitive head region. First pathologic investigations pointed out that with the use of the bipolar technique the surface of the concha with the ciliary epithelium is less affected due tot he limited spatial current distribution. Furthermore the design of a multi-electrode needle is presented which could probably offer an additional increase of safety and a simplification of performing a concha coagulation procedure. The new design of a bipolar needle electrode enables the surgeon the use of a partial application of radio frequency current for ITT. Less power is needed due to the limited current distribution at the immediate operation site, which means that a neutral electrode is not needed. Thus a highly safe procedure can be performed by the surgeon.

Desinger, Kai; Stein, Thomas; Mueller, Gerhard J.

1996-12-01

86

Gurley Dip Needle Lake Superior Model with Case  

USGS Multimedia Gallery

Also known as a Forrester's Compass or Miner's Compass, a dip (or dipping) needle is an instrument for measuring the intensity of the earth's magnetic field. It is used to locate buried or hidden metal. Manufactured by W. & L.E. Gurley, Troy, New York. Object ID: USGS-000345...

2009-07-22

87

Improved targeting device and computer navigation for accurate placement of brachytherapy needles  

SciTech Connect

Successful treatment of skull base tumors with interstitial brachytherapy requires high targeting accuracy for the brachytherapy needles to avoid harming vital anatomical structures. To enable safe placement of the needles in this area, we developed an image-based planning and navigation system for brachytherapy, which includes a custom-made mechanical positioning arm that allows rough and fine adjustment of the needle position. The fine-adjustment mechanism consists of an XYZ microstage at the base of the arm and a needle holder with two fine-adjustable inclinations. The rotation axes of the inclinations cross at the tip of the needle so that the inclinational adjustments do not interfere with the translational adjustments. A vacuum cushion and a noninvasive fixation frame are used for the head immobilization. To avoid mechanical bending of the needles due to the weight of attached tracking markers, which would be detrimental for targeting accuracy, only a single LED marker on the tail of the needle is used. An experimental phantom-based targeting study with this setup demonstrated that a positioning accuracy of 1.4 mm (rms) can be achieved. The study showed that the proposed setup allows brachytherapy needles to be easily aligned and inserted with high targeting accuracy according to a preliminary plan. The achievable accuracy is higher than if the needles are inserted manually. The proposed system can be linked to a standard afterloader and standard dosimetry planning module. The associated additional effort is reasonable for the clinical practice and therefore the proposed procedure provides a promising tool for the safe treatment of tumors in the skull base area.

Pappas, Ion P.I.; Ryan, Paul; Cossmann, Peter; Kowal, Jens; Borgeson, Blake; Caversaccio, Marco [M.E. Mueller Research Center, University of Bern, Stauffacherstr. 78, CH-3014 Bern (Switzerland); Hirslanden Klinik Aarau, Department of Radiation Oncology, Rain 34, CH-5000 Aarau (Switzerland); M.E. Mueller Research Center, University of Bern, Stauffacherstr. 78, CH-3014 Bern (Switzerland); Inselspital, Department of ORL, Head and Neck Surgery, University of Bern, CH-3010 Bern (Switzerland)

2005-06-15

88

Transurethral needle ablation of the prostate for treatment of benign prostatic hyperplasia: Early clinical experience  

Microsoft Academic Search

Objectives.Many attempts have been made to develop a method for treatment of benign prostatic hyperplasia (BPH) that is minimally invasive, efficacious, and low-cost. Transurethral needle ablation (TUNA) is a new, fast outpatient anesthesia-free procedure, using interstitial low-level radio frequency energy to produce a temperature above 100°C. We describe our early clinical experience with TUNA as an outpatient procedure.

Claude C. Schulman; Alexandre R. Zlotta

1995-01-01

89

Design Considerations for Robotic Needle Steering  

Microsoft Academic Search

Many medical procedures involve the use of needles, but targeting accuracy can be limited due to obstacles in the needle's path, shifts in target position caused by tissue deformation, and undesired bending of the needle after insertion. In order to address these limitations, we have developed robotic systems that actively steer a needle in soft tissue. A bevel (asymmetric) tip

Robert J. Webster III; Jasenka Memisevic; Allison M. Okamura

2005-01-01

90

Needle insertion into soft tissue: A survey  

Microsoft Academic Search

Needle insertion in soft tissue has attracted considerable attention in recent years due to its application in minimally invasive percutaneous procedures such as biopsies and brachytherapy. This paper presents a survey of the current state of research on needle insertion in soft tissue. It examines the topic from several aspects, e.g. modeling needle insertion forces, modeling tissue deformation and needle

Niki Abolhassani; Rajni Patel; Mehrdad Moallem

2007-01-01

91

Needle coke process and product  

SciTech Connect

A process is disclosed for the production of an improved grade of needle coke employing as a feedstock selected proportions of a pyrolysis furnace oil together with a hydrodesulfurized blend of a clarified oil and a lubricating oil extract.

Eickemeyer, D.B.; Rausch, M.K.; Tollefsen, G.E.

1984-08-21

92

On-line monitoring of multi-component strain development in a tufting needle using optical fibre Bragg grating sensors  

NASA Astrophysics Data System (ADS)

Dynamic loadings induced on a tufting needle during the tufting of dry carbon fibre preform via a commercial robot-controlled tufting head were investigated in situ and in real-time using optical fibre Bragg grating (FBG) sensors bonded to the needle shaft. The sensors were configured such that the axial strain and bending moments experienced by the needle could be measured. A study of the influence of thread and thread type on the strain imparted to the needle revealed axial strain profiles which had equivalent trends but different magnitudes. The mean of the maximum axial compression strains measured during the tufting of a 4-ply quasi-isotropic carbon fibre dry preform were - 499 ± 79 ??, - 463 ± 51 ?? and - 431 ± 59 ?? for a needle without thread, with metal wire and with Kevlar® thread, respectively. The needle similarly exhibited bending moments of different magnitude when the different needle feeding configurations were used.

Chehura, Edmon; Dell'Anno, Giuseppe; Huet, Tristan; Staines, Stephen; James, Stephen W.; Partridge, Ivana K.; Tatam, Ralph P.

2014-07-01

93

Interstitial granulomatous dermatitis with arthritis.  

PubMed

A 54-year-old woman with a history of arthritis presented for a long-standing history of symmetric, indurated plaques on her thighs and lateral aspects of the trunk. Histopathologic examination of skin biopsy specimens was consistent with interstitial granulomatous dermatitis, and a diagnosis of interstitial granulomatous dermatitis with arthritis was made. Administration of topical potent glucocorticoids, intralesional glucocorticoids, and narrow-band ultraviolet B phototherapy, in addition to continuation of systemic glucocorticoids and methotrexate, resulted in improvement of her cutaneous and musculoskeletal disease. PMID:19891930

Jabbari, Ali; Cheung, Wang; Kamino, Hideko; Soter, Nicholas A

2009-01-01

94

Dormant Microbes in Interstitial Cystitis  

Microsoft Academic Search

Interstitial cystitis (IC) is an inflammatory disease of the urinary bladder that has no known etiology. A microbial association with this disease has not been supported since routine cultures of urine from IC patients are usually negative. However, we have demonstrated the presence of bacterial 16S rRNA genes in bladder biopsies from 29 percent of patients with IC, but not

Gerald J. Domingue; Gamal M. Ghoniem; Kenneth L. Bost; Cesar Fermin; Liset G. Human

1995-01-01

95

Interstitial Vascularity in Fibrosing Alveolitis  

Microsoft Academic Search

The aim of this study was to evaluate interstitial vascularity in crypto- humoral autoimmunity, is often associated with lung involve- genic fibrosing alveolitis (CFA) and in fibrosing alveolitis associated ment. Vascular involvement in SSc is exemplified by the with systemic sclerosis (FASSc). Open lung biopsies from eight pa- typical changes of nailfold capillaries, which include enlarged tients with CFA, nine

Elisabetta A. Renzoni; David A. Walsh; Michael Salmon; Athol U. Wells; Andrew G. Nicholson; Srihari Veeraraghavan; Anne E. Bishop; Hanna M. Romanska; Panagiotis Pantelidis; Carol M. Black

2003-01-01

96

Interstitial thermotherapy with bipolar electrosurgical devices  

NASA Astrophysics Data System (ADS)

In addition to the laser, microwave or other energy sources, interstitial thermotherapy with radio-frequency current (RFITT) in bipolar technique has already been shown in vitro to be a safe and economical alternative energy source with a comparable operating performance. The bipolar technique is, from the technical point of view, completely without risk whereas with monopolar devices, where a neutral electrode has to be applied, an uncontrolled current flow passes through the patient's body. The therapeutical application efficiency of these bipolar RF-needle applicators was evaluated using newly designed high performance flushed and cooled probes (qq 3 mm). These can be used to create large coagulation volumes in tissue such as for the palliative treatment of liver metastases or the therapy of the benign prostate hyperplasia. As a result, the achievable lesion size resulting from these flushed and internally cooled RF- probes could be increased by a factor of three compared to a standard bipolar probe. With these bipolar power RF- applicators, coagulation dimensions of 5 cm length and 4 cm diameter with a power input of 40 watt could be achieved within 20 minutes. No carbonization and electrode tissue adherence was found. Investigations in vitro with adapted RFITT-probes using paramagnetic materials such as titanium alloys and high performance plastic have shown that monitoring under MRI (Siemens Magnetom, 1.5 Tesla), allows visualization of the development of the spatial temperature distribution in tissue using an intermittent diagnostic and therapeutical application. This does not lead to a loss in performance compared to continuous application. A ratio of 1:4 (15 s Thermo Flash MRI, 60 s RF-energy) has shown to be feasible.

Desinger, Kai; Stein, Thomas; Boehme, A.; Mack, Martin G.; Mueller, Gerhard J.

1998-01-01

97

Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method.  

PubMed

Laser immunotherapy (LIT) uses a synergistic approach to treat cancer systemically through local laser irradiation and immunological stimulation. Currently, LIT utilizes dye-assisted noninvasive laser irradiation to achieve selective photothermal interaction. However, LIT faces difficulties treating deeper tumors or tumors with heavily pigmented overlying skin. To circumvent these barriers, we use interstitial laser irradiation to induce the desired photothermal effects. The purpose of this study is to analyze the thermal effects of interstitial irradiation using proton resonance frequency (PRF). An 805-nm near-infrared laser with an interstitial cylindrical diffuser was used to treat rat mammary tumors. Different power settings (1.0, 1.25, and 1.5 W) were applied with an irradiation duration of 10 min. The temperature distributions of the treated tumors were measured by a 7 T magnetic resonance imager using PRF. We found that temperature distributions in tissue depended on both laser power and time settings, and that variance in tissue composition has a major influence in temperature elevation. The temperature elevations measured during interstitial laser irradiation by PRF and thermocouple were consistent, with some variations due to tissue composition and the positioning of the thermocouple's needle probes. Our results indicated that, for a tissue irradiation of 10 min, the elevation of rat tumor temperature ranged from 8 to 11°C for 1 W and 8 to 15°C for 1.5 W. This is the first time a 7 T magnetic resonance imager has been used to monitor interstitial laser irradiation via PRF. Our work provides a basic understanding of the photothermal interaction needed to control the thermal damage inside a tumor using interstitial laser treatment. Our work may lead to an optimal protocol for future cancer treatment using interstitial phototherapy in conjunction with immunotherapy. PMID:22191937

Le, Kelvin; Li, Xiaosong; Figueroa, Daniel; Towner, Rheal A; Garteiser, Philippe; Saunders, Debra; Smith, Nataliya; Liu, Hong; Hode, Tomas; Nordquist, Robert E; Chen, Wei R

2011-12-01

98

Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method  

PubMed Central

Laser immunotherapy (LIT) uses a synergistic approach to treat cancer systemically through local laser irradiation and immunological stimulation. Currently, LIT utilizes dye-assisted noninvasive laser irradiation to achieve selective photothermal interaction. However, LIT faces difficulties treating deeper tumors or tumors with heavily pigmented overlying skin. To circumvent these barriers, we use interstitial laser irradiation to induce the desired photothermal effects. The purpose of this study is to analyze the thermal effects of interstitial irradiation using proton resonance frequency (PRF). An 805-nm near-infrared laser with an interstitial cylindrical diffuser was used to treat rat mammary tumors. Different power settings (1.0, 1.25, and 1.5 W) were applied with an irradiation duration of 10 min. The temperature distributions of the treated tumors were measured by a 7 T magnetic resonance imager using PRF. We found that temperature distributions in tissue depended on both laser power and time settings, and that variance in tissue composition has a major influence in temperature elevation. The temperature elevations measured during interstitial laser irradiation by PRF and thermocouple were consistent, with some variations due to tissue composition and the positioning of the thermocouple's needle probes. Our results indicated that, for a tissue irradiation of 10 min, the elevation of rat tumor temperature ranged from 8 to 11°C for 1 W and 8 to 15°C for 1.5 W. This is the first time a 7 T magnetic resonance imager has been used to monitor interstitial laser irradiation via PRF. Our work provides a basic understanding of the photothermal interaction needed to control the thermal damage inside a tumor using interstitial laser treatment. Our work may lead to an optimal protocol for future cancer treatment using interstitial phototherapy in conjunction with immunotherapy. PMID:22191937

Le, Kelvin; Li, Xiaosong; Figueroa, Daniel; Towner, Rheal A.; Garteiser, Philippe; Saunders, Debra; Smith, Nataliya; Liu, Hong; Hode, Tomas; Nordquist, Robert E.; Chen, Wei R.

2011-01-01

99

Red Band Needle Blight TERMS OF REFERENCE  

E-print Network

Red Band Needle Blight TERMS OF REFERENCE Purpose 1. The Programme Board has been formed to have an overview of the administration and science of Red Band Needle Blight (RBNB), to underpin decisions made

100

Clinical Use of the Utrecht Applicator for Combined Intracavitary/Interstitial Brachytherapy Treatment in Locally Advanced Cervical Cancer  

SciTech Connect

Purpose: The aims of this study were to investigate the benefit of the Utrecht interstitial CT/MR applicator for combined intracavitary/interstitial (IC/IS) approach, using magnetic resonance imaging-guided brachytherapy, over the intracavitary approach alone in patients with locally advanced cervical cancer and to analyze the clinical use of needles. Methods and Materials: This study includes the first 20 patients treated with the new applicator. Brachytherapy consisted of two pulsed dose rate applications, and the second application was performed with the IC/IS approach. The number of needles, chosen guiding holes through the ovoids, and insertion depths were based on the dose distribution and dosimetric shortcomings of the first application (IC alone). We investigated the dosimetric gain by comparing the clinical interstitial optimized plan (IC/IS{sub clinical}) with an additionally generated optimized plan without needle use (IC{sub study}). Furthermore, we studied the relation of the inserted needles and their source loading patterns with the high-risk clinical target volume (HR-CTV). Results: A total of 54 needles (range, 1-6 per application) were applied with an average depth of 25 mm. The chosen needle positions corresponded with the location of the HR-CTV extensions. The total and individual needle treatment times per application were on average 19% (range, 4-35%) and 7% (range, 2-14%) of the implant treatment time, respectively. The total (external-beam radiotherapy + brachytherapy) D90 HR-CTV for the IC{sub study} and the IC/IS{sub clinical} were on average 79.5 (SD 7.4) Gy{sub {alpha}/{beta}10} and 83.9 (SD 6.7) Gy{sub {alpha}/{beta}10}, respectively, with an average gain of 4.4 (SD 2.3) Gy{sub {alpha}/{beta}10} for the second application. Conclusions: Needle placement was feasible in all patients and resulted in a gain in dose and better coverage of HR-CTV. Defining the location of HR-CTV protrusions and analyzing the associated needles has given us deeper understanding of the possibilities in magnetic resonance imaging-guided (pre)treatment planning with the IC/IS Utrecht applicator.

Nomden, Christel N., E-mail: c.nomden@umcutrecht.nl [Department of Radiation Oncology, University Medical Center Utrecht, Utrecht (Netherlands); Leeuw, Astrid A.C. de; Moerland, Marinus A.; Roesink, Judith M.; Tersteeg, Robbert J.H.A.; Juergenliemk-Schulz, Ina Maria [Department of Radiation Oncology, University Medical Center Utrecht, Utrecht (Netherlands)

2012-03-15

101

21 CFR 882.4650 - Neurosurgical suture needle.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 false Neurosurgical suture needle. 882.4650 Section 882.4650 Food...Devices § 882.4650 Neurosurgical suture needle. (a) Identification. A neurosurgical suture needle is a needle used in suturing during...

2010-04-01

102

Secure Container For Discarded Hypodermic Needles  

NASA Technical Reports Server (NTRS)

Container designed for safe retention of discarded blood-collecting hypodermic needles and similar sharp objects used in life-science experiments aboard spacecraft. Needles inserted through self-closing lid and retained magnetically. They are inserted, sharp end first, through spring-loaded flap. Long needles and needles on syringes cannot turn around in container. Can be emptied, cleaned, and reused. Used on Earth to provide unusually secure containment of sharp objects.

Lee, Angelene M.

1992-01-01

103

Needle-tissue interaction forces for bevel-tip steerable needles  

Microsoft Academic Search

The asymmetry of a bevel-tip needle results in the needle naturally bending when it is inserted into soft tissue. As a first step toward modeling the mechanics of deflection of the needle, we determine the forces at the bevel tip. In order to find the forces acting at the needle tip, we measure rupture toughness and nonlinear material elasticity parameters

Sarthak Misra; Kyle B. Reed; Andrew S. Douglas; K. T. Ramesh; Allison M. Okamura

2008-01-01

104

Sirolimus induced granulomatous interstitial pneumonitis  

PubMed Central

Objectives Report a case of sirolimus induced granulomatous pneumonitis. Background Sirolimus is used in clinical transplantation as an immunosuppressive agent. Pulmonary toxicity does occur, but only a few cases of sirolimus associated granulomatous interstitial pneumonitis have been reported. Methods Case report and literature review. Results This 53-year-old woman with ESRD from polycystic kidney disease status post deceased donor kidney transplantation presented with fever, progressive dyspnea, and hypoxia for two weeks. She had been switched to sirolimus two months before admission. A CT scan of the chest revealed bilateral ill-defined patchy ground glass opacities. Extensive investigations were negative for infection. Video-assisted thoracoscopic biopsy showed granulomatous interstitial pneumonitis. Her symptoms and infiltrates resolved after sirolimus discontinuation and corticosteroid treatment. Conclusions Drugs induced pneumonitis should always be considered in transplant patients after infectious or other etiologies have been excluded. Sirolimus can cause granulomatous infiltrates in the lung possibly secondary to T-cell mediated hypersensitivity.

Ussavarungsi, Kamonpun; Elsanjak, Abdelaziz; Laski, Melvin; Raj, Rishi; Nugent, Kenneth

2012-01-01

105

Preliminary work of a smart needling project  

Microsoft Academic Search

Precise needle placement is vital for the success of a wide variety of percutaneous surgical procedures. Insertions into soft tissues can be difficult to learn and to perform, due to tissue deformation, needle deflection and limited visual feedback. Little quantitative information is known about the interaction between needles and soft tissues during puncture. We are carrying out a \\

Kaiguo Yan; Tien-I. Liu; Keck Voon Ling; Yan Yu; Walter O'Dell; Ng Wan Sing

2005-01-01

106

Amiodarone induced acute interstitial pneumonitis.  

PubMed

Amiodarone has several potentially fatal toxicities, the most important of which is amiodarone pulmonary toxicity (APT). We report a rare case where a patient developed acute interstitial pneumonitis 2 days after starting amiodarone. This report reveals the potential for rapid onset of APT and will help to increase awareness among health care professionals who very often underestimate the incidence of the toxic effects of amiodarone. A simple, cost effective screening tool to detect APT in its early stage is recommended. PMID:21686894

Thiyagarajan, Thanigaiarsu; Mahajan, Vijay; Katragadda, Srinivas; Kumaraguru, Priya

2009-01-01

107

Amiodarone induced acute interstitial pneumonitis  

PubMed Central

Amiodarone has several potentially fatal toxicities, the most important of which is amiodarone pulmonary toxicity (APT). We report a rare case where a patient developed acute interstitial pneumonitis 2 days after starting amiodarone. This report reveals the potential for rapid onset of APT and will help to increase awareness among health care professionals who very often underestimate the incidence of the toxic effects of amiodarone. A simple, cost effective screening tool to detect APT in its early stage is recommended. PMID:21686894

Thiyagarajan, Thanigaiarsu; Mahajan, Vijay; Katragadda, Srinivas; Kumaraguru, Priya

2009-01-01

108

MRI-guided prostate focal laser ablation therapy using a mechatronic needle guidance system  

NASA Astrophysics Data System (ADS)

Focal therapy of localized prostate cancer is receiving increased attention due to its potential for providing effective cancer control in select patients with minimal treatment-related side effects. Magnetic resonance imaging (MRI)-guided focal laser ablation (FLA) therapy is an attractive modality for such an approach. In FLA therapy, accurate placement of laser fibers is critical to ensuring that the full target volume is ablated. In practice, error in needle placement is invariably present due to pre- to intra-procedure image registration error, needle deflection, prostate motion, and variability in interventionalist skill. In addition, some of these sources of error are difficult to control, since the available workspace and patient positions are restricted within a clinical MRI bore. In an attempt to take full advantage of the utility of intraprocedure MRI, while minimizing error in needle placement, we developed an MRI-compatible mechatronic system for guiding needles to the prostate for FLA therapy. The system has been used to place interstitial catheters for MRI-guided FLA therapy in eight subjects in an ongoing Phase I/II clinical trial. Data from these cases has provided quantification of the level of uncertainty in needle placement error. To relate needle placement error to clinical outcome, we developed a model for predicting the probability of achieving complete focal target ablation for a family of parameterized treatment plans. Results from this work have enabled the specification of evidence-based selection criteria for the maximum target size that can be confidently ablated using this technique, and quantify the benefit that may be gained with improvements in needle placement accuracy.

Cepek, Jeremy; Lindner, Uri; Ghai, Sangeet; Davidson, Sean R. H.; Trachtenberg, John; Fenster, Aaron

2014-03-01

109

Interstitial guidance of cancer invasion.  

PubMed

Cancer cell invasion into healthy tissues develops preferentially along pre-existing tracks of least resistance, followed by secondary tissue remodelling and destruction. The tissue scaffolds supporting or preventing guidance of invasion vary in structure and molecular composition between organs. In the brain, the guidance is provided by myelinated axons, astrocyte processes, and blood vessels which are used as invasion routes by glioma cells. In the human breast, containing interstitial collagen-rich connective tissue, disseminating breast cancer cells preferentially invade along bundled collagen fibrils and the surface of adipocytes. In both invasion types, physical guidance prompted by interfaces and space is complemented by molecular guidance. Generic mechanisms shared by most, if not all, tissues include (i) guidance by integrins towards fibrillar interstitial collagen and/or laminins and type IV collagen in basement membranes decorating vessels and adipocytes, and, likely, CD44 engaging with hyaluronan; (ii) haptotactic guidance by chemokines and growth factors; and likely (iii) physical pushing mechanisms. Tissue-specific, resticted guidance cues include ECM proteins with restricted expression (tenascins, lecticans), cell-cell interfaces, and newly secreted matrix molecules decorating ECM fibres (laminin-332, thrombospondin-1, osteopontin, periostin). We here review physical and molecular guidance mechanisms in interstitial tissue and brain parenchyma and explore shared principles and organ-specific differences, and their implications for experimental model design and therapeutic targeting of tumour cell invasion. PMID:22006671

Gritsenko, Pavlo G; Ilina, Olga; Friedl, Peter

2012-01-01

110

New Coaxial Transseptal Needle for Creation of Atrial Septal Defects in Adult Sheep  

SciTech Connect

Objectives: To introduce a new transseptal (TS) needle assembled in our laboratory-the coaxial TS (CTS) needle-and describe our experience with it in creating experimental atrial septal defects (ASD) in adult sheep.BackgroundWith commercially available TS needles, we were not able to consistently perform TS puncture at the fossa ovalis in adult sheep.Material and MethodsTen adult sheep with a mean weight of 63.5 kg were used. The CTS needle consists of four components: a 9F Teflon catheter, a 14-gauge blunt curved-tip metal cannula, a 4F tapered catheter, and a 20-gauge open needle. A transjugular 5F pigtail catheter was used to display the septal anatomy by angiocardiography and was left in place to mark the level of the fossa ovalis. The septum was then probed by a transfemoral 5F curved-tip end-hole catheter. The CTS needle was aligned with the tip of the transjugular catheter, and the TS puncture was performed under fluoroscopic guidance. After documenting a left atrial position, a balloon angioplasty catheter was used for creation of the ASD. Results: A small patent foramen ovale was discovered by septal probing in one sheep. All sheep underwent successful TS punctures without complications. The ASD size ranged from 13 to 15 mm. In eight sheep, the ASD was in fossa ovalis. In the first two sheep where the needle was not well aligned with the marking catheter, the ASD was in the septum secundum. No damage to the atrial or other heart structures was found at necropsy. Conclusion: The CTS needle is a suitable needle for TS puncture and ASD creation in adult sheep. Proper alignment of the CTS needle with a catheter marking the fossa ovalis is essential for successful puncture.

Uchida, Barry T.; Pavcnik, Dusan, E-mail: pavcnikd@ohsu.edu; Shimohira, Masashi; Choi, Young Ho; Jeromel, Miran; Keller, Frederick S.; Roesch, Josef [Oregon Health and Science University, Dotter Interventional Institute (United States)

2011-06-15

111

De novo 10q22 interstitial deletion  

PubMed Central

We describe a 4 month old male with a de novo interstitial deletion of chromosome 10q22. His clinical features included growth deficiency, developmental delay, ocular hypertelorism, posteriorly rotated ears, retrognathia, and fifth finger clinodactyly. He later developed dental lamina cysts of the alveolar ridge. To our knowledge, this is the first reported case of an interstitial deletion of 10q22. ???Keywords: chromosome 10; interstitial deletion; deletion 10q; multiple congenital anomaly (MCA) syndrome PMID:9950372

Cook, L.; Weaver, D.; Hartsfield, J.; Vance, G.

1999-01-01

112

Contaminated marine sediments: Water column and interstitial toxic effects  

SciTech Connect

The toxicity that contaminated sediments may introduce into the water column has not been measured extensively. In order to quantify this potential toxicity, the seawater overlying two uncontaminated and three contaminated marine sediments was evaluated in the laboratory with the sea urchin Arbacia punctulata fertilization test. Concentration of polychlorinated biphenyls (PCBs) and copper, as representative contaminants, were also measured. To characterize sources of toxicity, samples were chemically manipulated using reversed-phase chromatography, cation exchange, and chelation. Water column toxicity and contaminant concentrations were higher in the suspended exposures than in bedded exposures. Interstitial water toxicity and contaminant concentrations were generally greater than either bedded or suspended exposures. Chemical manipulation indicated that the observed toxicity in water column exposures was probably caused by metallic and/or nonionic organic contaminants. Conversely, manipulation of interstitial water did not result in significantly reduced toxicity, suggesting that other toxicants such as ammonia and hydrogen sulfide may be active.

Burgess, R.M.; McKinney, R.A. (Science Applications International Corp., Narragansett, RI (United States)); Schweitzer, K.A. (Chemical Waste Management, Inc., Dartmouth, MA (United States)); Phelps, D.K. (Environmental Protection Agency, Narragansett, RI (United States))

1993-01-01

113

Contaminated marine sediments: Water column and interstitial toxic effects  

SciTech Connect

The toxicity that contaminated sediments may introduce into the water column has not been measured extensively. In order to quantify this potential toxicity, the seawater overlying two uncontaminated and three contaminated marine sediments was evaluated in the laboratory with the sea urchin Arbacia punctulata fertilization test. Concentrations of polychlorinated biphenyls (PCBs) and copper, as representative contaminants, were also measured. To characterize sources of toxicity, samples were chemically manipulated using reversed-phase chromatography, cation exchange, and chelation. Water column toxicity and contaminant concentrations were higher in the suspended exposures than in bedded exposures. Interstitial water toxicity and contaminant concentrations were generally greater than either bedded or suspended exposures. Chemical manipulation indicated that the observed toxicity in water column exposures was probably caused by metallic and/or nonionic organic contaminants. Conversely, manipulation of interstitial waters did not result in significantly reduced toxicity, suggesting that other toxicants such as ammonia and hydrogen sulfide may be active.

Burgess, R.M.; Schweitzer, K.A.; McKinney, R.A.; Phelps, D.K.

1993-01-01

114

Eosinophilic Pneumonia-like Areas in Idiopathic Usual Interstitial Pneumonia  

Microsoft Academic Search

Usual interstitial pneumonia is the most common idiopathic chronic interstitial pneumonia, characterized by a temporally heterogenous pattern of interstitial injury with interstitial mononuclear infiltrates, septal fibromyxoid nodules, and parenchymal scarring. This report details the presence of focal eosinophilic pneumonia in six cases of usual interstitial pneumonia in the absence of known causes of this reaction. The relationship of eosinophilic infiltrates

Samuel A. Yousem

2000-01-01

115

Update on lymphoid interstitial pneumonitis.  

PubMed

Lymphoid interstitial pneumonitis (LIP) involves a clinicopathologic pattern of pulmonary disease characterized by diffuse interstitial reactive lymphoid infiltrates. In adults, it occurs most commonly in autoimmune diseases, such as Sjögren's syndrome (0.9% of these patients) and primary biliary cirrhosis, whereas in children it is usually seen in HIV infection. Dysproteinemias (hyper- and hypogammaglobulinemia) are found in more than 60% of patients. Children can show CD8-lymphocytosis in bronchoalveolar lavage fluid, lung tissue, peripheral blood, and salivary gland, associated with HLA-DR5 haplotype. Radiographically, most patients with LIP have reticulonodular infiltrates, with or without patchy areas of consolidation. CT scans can show both small nodular and ground glass patterns, patterns that are diagnostically nonspecific. Reduced lung volumes and diffusing capacities are consistent and sensitive indicators of disease in LIP. In an experimental model, diffusing capacity was the single most sensitive functional index of disease progression. Microscopically, LIP is part of a spectrum of pulmonary lymphoid proliferations, ranging from follicular bronchitis-bronchiolitis and pulmonary lymphoid hyperplasia (the latter in AIDS patients), proliferations largely limited to airways, to low-grade malignant lymphoma. These patterns may be difficult to differentiate from each other. It appears that LIP sometimes evolves to lymphoma; the frequency of this evolution is probably low but is difficult to assess because low-grade lymphomas may mimic LIP. A relatively high frequency of LIP patients have Epstein-Barr virus DNA in their lungs but not all patients with LIP show this finding, suggesting other possible etiologies. PMID:9363179

Fishback, N; Koss, M

1996-09-01

116

Dry needling - peripheral and central considerations.  

PubMed

Dry needling is a common treatment technique in orthopedic manual physical therapy. Although various dry needling approaches exist, the more common and best supported approach targets myofascial trigger points. This article aims to place trigger point dry needling within the context of pain sciences. From a pain science perspective, trigger points are constant sources of peripheral nociceptive input leading to peripheral and central sensitization. Dry needling cannot only reverse some aspects of central sensitization, it reduces local and referred pain, improves range of motion and muscle activation pattern, and alters the chemical environment of trigger points. Trigger point dry needling should be based on a thorough understanding of the scientific background of trigger points, the differences and similarities between active and latent trigger points, motor adaptation, and central sensitize application. Several outcome studies are included, as well as comments on dry needling and acupuncture. PMID:23115475

Dommerholt, Jan

2011-11-01

117

[Interstitial lung diseases : The pattern is important].  

PubMed

Interstitial lung diseases (ILDs) comprise a number of rare entities with an estimated incidence of 10-25 per 100,000 inhabitants but the incidence greatly increases beyond the age of 65 years. The prognosis depends on the underlying cause. The fibrotic disorders show a set of radiological and histopathological patterns that are distinct but not entirely specific. In the absence of a clear clinical picture and consistent high resolution computed tomography (HRCT) findings, patients are advised to undergo surgical lung biopsies from two or three lung lobes (or transbronchial biopsies) to determine the histopathological pattern. The ILDs are differentiated into disorders of known causes (e.g. collagen vascular disease, drug-related), idiopathic interstitial pneumonia (IIP), granulomatous ILDs (e.g. sarcoidosis) and other forms of ILD (e.g. Langerhans' cell histiocytosis). The IIPs encompass idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia, desquamative interstitial pneumonia, respiratory bronchiolitis-interstitial lung disease, cryptogen organizing pneumonia, lymphocytic interstitial pneumonia and acute interstitial pneumonia. Additionally, a category of unclassified interstitial pneumonia exists. The pathologist has to recognize and address the histopathological pattern. In a multidisciplinary discussion the disorder is allocated to a clinicopathological entity and the histopathological pattern plays a major role in the classification of the entity. Recognition of the underlying pattern and the respective histopathological differential diagnoses is important as the therapy varies depending on the cause and ranges from elimination of the stimulus (if possible) to antifibrotic drug therapy up to preparation for lung transplantation. PMID:25319226

Fink, L

2014-11-01

118

Interstitial granulomatous dermatitis associated with darifenacin.  

PubMed

Interstitial granulomatous dermatitis is most commonly associated with rheumatoid arthritis (RA) but may be induced by medications as well. Darifenacin is a muscarinic antagonist which was FDA approved for the treatment of overactive bladder in December 2004. The authors describe a case of interstitial granulomatous dermatitis associated with darifenacin. PMID:19112808

Mason, Holly R; Swanson, Jil K; Ho, Jonhan; Patton, Timothy J

2008-09-01

119

Interstitial granulomatous dermatitis associated with pulmonary coccidioidomycosis  

Microsoft Academic Search

Background:Coccidioides immitis is a soil-dwelling fungus found in arid regions of the Western Hemisphere. Interstitial granulomatous dermatitis is a histopathologic pattern that may be a reactive manifestation of diverse systemic diseases. Objective: Our purpose was to describe clinical and histopathologic findings in 5 patients who presented with interstitial granulomatous dermatitis associated with pulmonary coccidioidomycosis. Methods: Medical records and skin biopsy

David J. DiCaudo; Suzanne M. Connolly

2001-01-01

120

Observations and models for needle-tissue interactions  

Microsoft Academic Search

The asymmetry of a bevel-tip needle results in the needle naturally bending when it is inserted into soft tissue. In this study we present a mechanics-based model that calculates the deflection of the needle embedded in an elastic medium. Microscopic observations for several needle- gel interactions were used to characterize the interactions at the bevel tip and along the needle

Sarthak Misra; Kyle B. Reed; Benjamin W. Schafer; K. T. Ramesh; Allison M. Okamura

2009-01-01

121

Observations of Needle-Tissue Interactions  

PubMed Central

Needles with asymmetric bevel tips naturally bend when they are inserted into soft tissue. In this study, we present an analytical model for the loads developed at the bevel tip during needle-tissue interaction. The model calculates the loads based on the geometry of the bevel edge and gel material properties. The modeled transverse force developed at the tip is compared to forces measured experimentally. The analytical model explains the trends observed in the experiments. In addition to macroscopic studies, we also present microscopic observations of needle-tissue interactions. These results contribute to a mechanics-based model of robotic needle steering, extending previous work on kinematic models. PMID:19963709

Misra, Sarthak; Reed, Kyle B.; Ramesh, K. T.; Okamura, Allison M.

2010-01-01

122

Interstitials in copper-zinc alloys  

SciTech Connect

In Cu-30 Zn alloys during irradiation with 2-MeV electrons from a Van de Graff generator, the electrical resistivity first decreases due to radiation-enhanced ordering and then increases due to the formation of very small interstitial clusters. The activation energy during irradiation for both processes is approximately Q/subirr/ = 0.3/sub 7/ eV and is interpreted as half of the migration energy of freely migrating interstitials. For irradiation temperatures below 75/sup 0/C, a second resistivity increase is found that is attributed to the formation of stable interstitial clusters. The observed radiation-enhanced diffusion rates below ambient temperature are many orders of magnitude smaller and larger than those predicted by the one- and two-interstitial models, respectively, and these rates are in agreement with the predictions of the modified two-interstitial model.

Schule, W.

1986-07-01

123

Lymphocytic interstitial pneumonitis in HIV infected adults  

PubMed Central

Methods: A Medline search was performed using the key words "HIV," "pneumonitis," and "lymphocytes." A further search was performed with the MESH heading "interstitial lung disorders." Related articles were also searched using Pubmed. Results: Lymphocytic interstitial pneumonitis is a common complication in HIV infected children. In adults it is uncommon and is described most commonly among black African and Afro-Caribbean patients. The aetiology and pathogenesis of lymphocytic interstitial pneumonitis in HIV infection is not clear. The clinical and radiological presentations may be indistinguishable from Pneumocystis carinii infection and a lung biopsy is necessary to establish the diagnosis. Recent evidence suggests that lymphocytic interstitial pneumonitis in HIV infected patients may respond to combination antiretroviral therapy with dramatic improvements in clinical and radiological abnormalities. Conclusion: Lymphocytic interstitial pneumonitis in HIV infected patients is a treatable condition. This condition should be considered in HIV infected patients presenting with respiratory symptoms as they may gain considerable benefit from antiretroviral therapy. PMID:12690125

Das, S; Miller, R

2003-01-01

124

An analytical model for deflection of flexible needles during needle insertion  

Microsoft Academic Search

This paper presents a new needle deflection model that is an extension of prior work in our group based on the principles of beam theory. The use of a long flexible needle in percutaneous interventions necessitates accurate modeling of the generated curved trajectory when the needle interacts with soft tissue. Finding a feasible model is important in simulators with applications

Ali Asadian; Mehrdad R. Kermani; Rajni V. Patel

2011-01-01

125

Red Band Needle Blight Programme Red Band Needle Blight of Pine Programme Group  

E-print Network

Red Band Needle Blight Programme Group Red Band Needle Blight of Pine Programme Group Minutes Support Welcome and introduction 1. Jim thanked everyone for attending the first meeting of the Red Band and that the private 1 | Paper 1 - Minutes | Debbie Erskine | 23/01/2009 #12;Red Band Needle Blight Programme Group

126

Geographical and climatic limits of needle types of one- and two-needled pinyon pines  

PubMed Central

Aim The geographical extent and climatic tolerances of one- and two-needled pinyon pines (Pinus subsect. Cembroides) are the focus of questions in taxonomy, palaeoclimatology and modelling of future distributions. The identification of these pines, traditionally classified by one- versus two-needled fascicles, is complicated by populations with both one- and two-needled fascicles on the same tree, and the description of two more recently described one-needled varieties: the fallax-type and californiarum-type. Because previous studies have suggested correlations between needle anatomy and climate, including anatomical plasticity reflecting annual precipitation, we approached this study at the level of the anatomy of individual pine needles rather than species. Location Western North America. Methods We synthesized available and new data from field and herbarium collections of needles to compile maps of their current distributions across western North America. Annual frequencies of needle types were compared with local precipitation histories for some stands. Historical North American climates were modelled on a c. 1-km grid using monthly temperature and precipitation values. A geospatial model (ClimLim), which analyses the effect of climate-modulated physiological and ecosystem processes, was used to rank the importance of seasonal climate variables in limiting the distributions of anatomical needle types. Results The pinyon needles were classified into four distinct types based upon the number of needles per fascicle, needle thickness and the number of stomatal rows and resin canals. The individual needles fit well into four categories of needle types, whereas some trees exhibit a mixture of two needle types. Trees from central Arizona containing a mixture of Pinus edulis and fallax-type needles increased their percentage of fallax-type needles following dry years. All four needle types occupy broader geographical regions with distinctive precipitation regimes. Pinus monophylla and californiarum-type needles occur in regions with high winter precipitation. Pinus edulis and fallax-type needles are found in regions with high monsoon precipitation. Areas supporting californiarum-type and fallax-type needle distributions are additionally characterized by a more extreme May–June drought. Main conclusions These pinyon needle types seem to reflect the amount and seasonality of precipitation. The single needle fascicle characterizing the fallax type may be an adaptation to early summer or periodic drought, while the single needle of Pinus monophylla may be an adaptation to summer–autumn drought. Although the needles fit into four distinct categories, the parent trees are sometimes less easily classified, especially near their ancestral Pleistocene ranges in the Mojave and northern Sonoran deserts. The abundance of trees with both one- and two-needled fascicles in the zones between P. monophylla, P. edulis and fallax-type populations suggest that needle fascicle number is an unreliable characteristic for species classification. Disregarding needle fascicle number, the fallax-type needles are nearly identical to P. edulis, supporting Little’s (1968) initial classification of these trees as P. edulis var. fallax, while the californiarum-type needles have a distinctive morphology supporting Bailey’s (1987) classification of this tree as Pinus californiarum. PMID:21188300

Cole, Kenneth L; Fisher, Jessica; Arundel, Samantha T; Cannella, John; Swift, Sandra

2008-01-01

127

Geographical and climatic limits of needle types of one- and two-needled pinyon pines  

USGS Publications Warehouse

Aim: The geographical extent and climatic tolerances of one- and two-needled pinyon pines (Pinus subsect. Cembroides) are the focus of questions in taxonomy, palaeoclimatology and modelling of future distributions. The identification of these pines, traditionally classified by one- versus two-needled fascicles, is complicated by populations with both one- and two-needled fascicles on the same tree, and the description of two more recently described one-needled varieties: the fallax-type and californiarum-type. Because previous studies have suggested correlations between needle anatomy and climate, including anatomical plasticity reflecting annual precipitation, we approached this study at the level of the anatomy of individual pine needles rather than species. Location: Western North America. Methods: We synthesized available and new data from field and herbarium collections of needles to compile maps of their current distributions across western North America. Annual frequencies of needle types were compared with local precipitation histories for some stands. Historical North American climates were modelled on a c. 1-km grid using monthly temperature and precipitation values. A geospatial model (ClimLim), which analyses the effect of climate-modulated physiological and ecosystem processes, was used to rank the importance of seasonal climate variables in limiting the distributions of anatomical needle types. Results: The pinyon needles were classified into four distinct types based upon the number of needles per fascicle, needle thickness and the number of stomatal rows and resin canals. The individual needles fit well into four categories of needle types, whereas some trees exhibit a mixture of two needle types. Trees from central Arizona containing a mixture of Pinus edulis and fallax-type needles increased their percentage of fallax-type needles following dry years. All four needle types occupy broader geographical regions with distinctive precipitation regimes. Pinus monophylla and californiarum-type needles occur in regions with high winter precipitation. Pinus edulis and fallax-type needles are found in regions with high monsoon precipitation. Areas supporting californiarum-type and fallax-type needle distributions are additionally characterized by a more extreme May-June drought. Main conclusions: These pinyon needle types seem to reflect the amount and seasonality of precipitation. The single needle fascicle characterizing the fallax type may be an adaptation to early summer or periodic drought, while the single needle of Pinus monophylla may be an adaptation to summer-autumn drought. Although the needles fit into four distinct categories, the parent trees are sometimes less easily classified, especially near their ancestral Pleistocene ranges in the Mojave and northern Sonoran deserts. The abundance of trees with both one- and two-needled fascicles in the zones between P. monophylla, P. edulis and fallax-type populations suggest that needle fascicle number is an unreliable characteristic for species classification. Disregarding needle fascicle number, the fallax-type needles are nearly identical to P. edulis, supporting Little's (1968) initial classification of these trees as P. edulis var. fallax, while the californiarum-type needles have a distinctive morphology supporting Bailey's (1987) classification of this tree as Pinus californiarum.

Cole, K. L.; Fisher, J.; Arundel, S. T.; Cannella, J.; Swift, S.

2008-01-01

128

21 CFR 868.5150 - Anesthesia conduction needle.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 false Anesthesia conduction needle. 868.5150 Section 868.5150 Food... § 868.5150 Anesthesia conduction needle. (a) Identification. An anesthesia conduction needle is a device used to inject local...

2010-04-01

129

21 CFR 880.6920 - Syringe needle introducer.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 2010-04-01 false Syringe needle introducer. 880.6920 Section 880...Miscellaneous Devices § 880.6920 Syringe needle introducer. (a) Identification. A syringe needle introducer is a device that uses a...

2010-04-01

130

21 CFR 880.5570 - Hypodermic single lumen needle.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 false Hypodermic single lumen needle. 880.5570 Section 880.5570 Food... § 880.5570 Hypodermic single lumen needle. (a) Identification. A hypodermic single lumen needle is a device intended to inject...

2010-04-01

131

21 CFR 868.5150 - Anesthesia conduction needle.  

Code of Federal Regulations, 2013 CFR

...2013-04-01 2013-04-01 false Anesthesia conduction needle. 868.5150 ...Therapeutic Devices § 868.5150 Anesthesia conduction needle. (a) Identification. An anesthesia conduction needle is a device...

2013-04-01

132

21 CFR 868.5150 - Anesthesia conduction needle.  

...2014-04-01 2014-04-01 false Anesthesia conduction needle. 868.5150 ...Therapeutic Devices § 868.5150 Anesthesia conduction needle. (a) Identification. An anesthesia conduction needle is a device...

2014-04-01

133

21 CFR 868.5150 - Anesthesia conduction needle.  

Code of Federal Regulations, 2012 CFR

...2012-04-01 2012-04-01 false Anesthesia conduction needle. 868.5150 ...Therapeutic Devices § 868.5150 Anesthesia conduction needle. (a) Identification. An anesthesia conduction needle is a device...

2012-04-01

134

21 CFR 868.5150 - Anesthesia conduction needle.  

Code of Federal Regulations, 2011 CFR

...2011-04-01 2011-04-01 false Anesthesia conduction needle. 868.5150 ...Therapeutic Devices § 868.5150 Anesthesia conduction needle. (a) Identification. An anesthesia conduction needle is a device...

2011-04-01

135

Energetics of Oxygen Interstitials in Cr and V  

NASA Technical Reports Server (NTRS)

Dissolved oxygen in group IIIA-VA (Nb, Ti, Zr, Y) based alloys is a fundamental problem, affecting both mechanical properties and oxidation resistance, yet details of the phenomenon are poorly understood. In these alloys, oxygen is more stable dissolved in the metal than as an oxide-compound. In contrast, alloys based on Ni, Fe, Al and Cr exhibit almost no oxygen solubility. To improve the performance of Nb and Ti based alloys it is necessary to understand the differences in oxygen solubility between these two groups of metals. As a first step we considered the energetics of interstitial oxygen in alpha-V and alpha-Cr. Both of these metals have a BCC structure, yet the oxygen solubility in V is much higher than that in Cr. We obtain total energies, densities of states and population analyses using the CASTEP plane-wave pseudopotential density functional computer code. The differences in the energetics and electronic structures of the two materials, particularly the partial densities of states associated with the interstitial oxygen, are discussed.

Good, Brian S.; Copland, Evan

2005-01-01

136

Needle Exchange Programs and Drug Injection Behavior  

ERIC Educational Resources Information Center

This study examines how drug injection and needle sharing propensities respond when a needle exchange program (NEP) is introduced into a city. I analyze 1989-1995 Drug Use Forecasting data on adult male arrestees from 24 large U.S. cities, in nine of which NEPs opened during the sample period. After controlling for cocaine and heroin prices, AIDS…

DeSimone, Jeff

2005-01-01

137

Needle steering and motion planning in soft tissues.  

PubMed

In this work, needle insertion into deformable tissue is formulated as a trajectory planning and control problem. A new concept of needle steering has been developed and a needle manipulation Jacobian defined using numerical needle insertion models that include needle deflection and soft tissue deformation. This concept is used in conjunction with a potential-field-based path planning technique to demonstrate needle tip placement and obstacle avoidance. Results from open loop insertion experiments are provided. PMID:15977726

DiMaio, Simon P; Salcudean, S E

2005-06-01

138

Barrier Coatings for Refractory Metals and Superalloys  

Microsoft Academic Search

In the closed working fluid loop of the proposed Prometheus space nuclear power plant (SNPP), there is the potential for reaction of core and plant structural materials with gas phase impurities and gas phase transport of interstitial elements between superalloy and refractory metal alloy components during service. Primary concerns are surface oxidation, interstitial embrittlement of refractory metals and decarburization of

SM Sabol; BT Randall; JD Edington; CJ Larkin; BJ Close

2006-01-01

139

Interstitial Ectopic Pregnancy: Conservative Surgical Management  

PubMed Central

Introduction: Interstitial pregnancy is a rare and life-threatening condition. Diagnosis and appropriate management are critical in preventing morbidity and death. Case Description: Four cases of interstitial pregnancy are presented. Diagnostic laparoscopy followed by laparotomy and cornuostomy with removal of products of conception was performed in 1 case. Laparoscopic cornuostomy and removal of products of conception were performed in the subsequent 3 cases with some modifications of the technique. Subsequent successful reproductive outcomes are also presented. Discussion: Progressively conservative surgical measures are being used to treat interstitial pregnancy successfully, with no negative impact on subsequent pregnancies. PMID:24960482

Warda, Hussein; Mamik, Mamta M.; Ashraf, Mohammad

2014-01-01

140

21 CFR 884.6100 - Assisted reproduction needles.  

... Assisted reproduction needles. (a) Identification. Assisted reproduction needles are devices used in in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), or other assisted reproduction procedures to obtain gametes...

2014-04-01

141

21 CFR 884.6100 - Assisted reproduction needles.  

Code of Federal Regulations, 2011 CFR

... Assisted reproduction needles. (a) Identification. Assisted reproduction needles are devices used in in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), or other assisted reproduction procedures to obtain gametes...

2011-04-01

142

21 CFR 884.6100 - Assisted reproduction needles.  

Code of Federal Regulations, 2012 CFR

... Assisted reproduction needles. (a) Identification. Assisted reproduction needles are devices used in in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), or other assisted reproduction procedures to obtain gametes...

2012-04-01

143

Ossicular injury caused by a knitting needle.  

PubMed

Ossicular chain injury is a complication of trauma caused to temporal bone, but rarely, it can also occur due to direct trauma caused to ossicular chain by a penetrating injury. Patients usually suffering from conductive hearing loss and vertigo, although a facial nerve injury is also a possibility. We are describing here a case of young male who presented with a penetrating trauma to the left ear, caused by a metallic knitting needle, that resulted in ossicular chain disruption. The patient suffered from severe vertigo and conductive hearing loss. He was advised complete bed rest and vertin for controlling vertigo, after which he recovered. Computed tomography is the investigation of choice for detecting and characterizing such injuries, for proper management of patients. Penetrating middle ear trauma differs from blunt trauma, as the mechanism of injury is distinct. The injury is usually isolated and an urgent repair may be needed. Hearing results after an immediate or a delayed ossiculoplasty are apparently satisfying, although late cases are assumed to be associated with adhesions or fibrosis. PMID:24551716

Singh, Amritpal; Kaur, Maninder

2013-12-01

144

Ossicular Injury Caused by A Knitting Needle  

PubMed Central

Ossicular chain injury is a complication of trauma caused to temporal bone, but rarely, it can also occur due to direct trauma caused to ossicular chain by a penetrating injury. Patients usually suffering from conductive hearing loss and vertigo, although a facial nerve injury is also a possibility. We are describing here a case of young male who presented with a penetrating trauma to the left ear, caused by a metallic knitting needle, that resulted in ossicular chain disruption. The patient suffered from severe vertigo and conductive hearing loss. He was advised complete bed rest and vertin for controlling vertigo, after which he recovered. Computed tomography is the investigation of choice for detecting and characterizing such injuries, for proper management of patients. Penetrating middle ear trauma differs from blunt trauma, as the mechanism of injury is distinct. The injury is usually isolated and an urgent repair may be needed. Hearing results after an immediate or a delayed ossiculoplasty are apparently satisfying, although late cases are assumed to be associated with adhesions or fibrosis. PMID:24551716

Singh, Amritpal; Kaur, Maninder

2013-01-01

145

Radiofrequency Cauterization with Biopsy Introducer Needle  

PubMed Central

PURPOSE The principal risks of needle biopsy are hemorrhage and implantation of tumor cells in the needle tract. This study compared hemorrhage after liver and kidney biopsy with and without radiofrequency (RF) ablation of the needle tract. MATERIALS AND METHODS Biopsies of liver and kidney were performed in swine through introducer needles modified to allow RF ablation with the distal 2 cm of the needle. After each biopsy, randomization determined whether the site was to undergo RF ablation during withdrawal of the introducer needle. Temperature was measured with a thermistor stylet near the needle tip, with a target temperature of 70°C–100°C with RF ablation. Blood loss was measured as grams of blood absorbed in gauze at the puncture site for 2 minutes after needle withdrawal. Selected specimens were cut for gross examination. RESULTS RF ablation reduced bleeding compared with absence of RF ablation in liver and kidney (P < .01), with mean blood loss reduced 63% and 97%, respectively. Mean amounts of blood loss (±SD) in the liver in the RF and no-RF groups were 2.03 g ± 4.03 (CI, 0.53–3.54 g) and 5.50 g ± 5.58 (CI, 3.33–7.66 g), respectively. Mean amounts of blood loss in the kidney in the RF and no-RF groups were 0.26 g ± 0.32 (CI, ?0.01 to 0.53 g) and 8.79 g ± 7.72 (CI, 2.34–15.24 g), respectively. With RF ablation, thermal coagulation of the tissue surrounding the needle tract was observed. CONCLUSION RF ablation of needle biopsy tracts reduced hemorrhage after biopsy in the liver and kidney and may reduce complications of hemorrhage as well as implantation of tumor cells in the tract. PMID:14963187

Pritchard, William F.; Wray-Cahen, Diane; Karanian, John W.; Hilbert, Stephen; Wood, Bradford J.

2014-01-01

146

Survival of patients with biopsy-proven usual interstitial pneumonia and nonspecific interstitial pneumonia  

Microsoft Academic Search

Survival of patients with biopsy-proven usual interstitial pneumonia and nonspecific interstitial pneumonia. R.L. Riha, E.E. Duhig, B.E. Clarke, R.H. Steele, R.E. Slaughter, P.V. Zimmerman. #ERS Journals Ltd 2002. ABSTRACT: This is the first Australian study to examine survival and clinical characteristics in biopsy-proven idiopathic interstitial pneumonia. A cohort of 70 patients from a single institution between January 1990 and December

R. L. Riha; E. E. Duhig; B. E. Clarke; R. H. Steele; R. E. Slaughter; P. V. Zimmerman

2002-01-01

147

Interstitial lung diseases in children  

PubMed Central

Interstitial lung disease (ILD) in infants and children comprises a large spectrum of rare respiratory disorders that are mostly chronic and associated with high morbidity and mortality. These disorders are characterized by inflammatory and fibrotic changes that affect alveolar walls. Typical features of ILD include dyspnea, diffuse infiltrates on chest radiographs, and abnormal pulmonary function tests with restrictive ventilatory defect and/or impaired gas exchange. Many pathological situations can impair gas exchange and, therefore, may contribute to progressive lung damage and ILD. Consequently, diagnosis approach needs to be structured with a clinical evaluation requiring a careful history paying attention to exposures and systemic diseases. Several classifications for ILD have been proposed but none is entirely satisfactory especially in children. The present article reviews current concepts of pathophysiological mechanisms, etiology and diagnostic approaches, as well as therapeutic strategies. The following diagnostic grouping is used to discuss the various causes of pediatric ILD: 1) exposure-related ILD; 2) systemic disease-associated ILD; 3) alveolar structure disorder-associated ILD; and 4) ILD specific to infancy. Therapeutic options include mainly anti-inflammatory, immunosuppressive, and/or anti-fibrotic drugs. The outcome is highly variable with a mortality rate around 15%. An overall favorable response to corticosteroid therapy is observed in around 50% of cases, often associated with sequelae such as limited exercise tolerance or the need for long-term oxygen therapy. PMID:20727133

2010-01-01

148

High-frequency current application in bipolar technique for interstitial thermotherapy (HF-ITT)  

NASA Astrophysics Data System (ADS)

For a minimally invasive treatment of pathologic tissue, e.g. tumors, the benign prostate hyperplasia (BPH) or the concha hyperplasia in otorhinolaryngology (ENT), next to the laser- induced interstitial thermotherapy (LITT) or the monopolar HF- surgery the interstitial thermotherapy with high-frequency alternating current (HF-ITT) in bipolar technique is a good alternative. Investigation results are presented which prove the feasibility and show the performance of this technique. Bipolar needles of different geometries, adapted to the various application fields, such as palliative treatment of metastatic carcinomas in liver and concha hyperplasia, were built and tested. Basic investigations of the thermal field distribution in in vitro samples were performed. The efficiency of the developed applicators were examined in in vitro experiments with porcine liver, turkey breast and porcine concha. Coagulation volumes of different needle diameters and power settings are show. Carbonization and dehydration can be avoided by irrigation of the tissue during treatment through integrated flushing ports and thus the performance is increased. For the treatment of concha hyperplasia special designs are presented which could probably offer an additional increase of safety and a simplification of performing a concha coagulation procedure. The new design of a bipolar needle electrode permits the surgeon the use of a partial application of high frequency current for ITT. Less power is needed due to the limited current distribution at the immediate operation site, which means that it is not necessary to fix the neutral electrode to the patient. Thus an easy to handle and a highly safe procedure can be performed by the surgeon.

Desinger, Kai; Stein, Thomas; Mueller, Gerhard J.

1997-05-01

149

Mathematical model of renal interstitial fibrosis.  

PubMed

Lupus nephritis (LN) is an autoimmune disease that occurs when autoantibodies complex with self-antigen and form immune complexes that accumulate in the glomeruli. These immune complexes initiate an inflammatory response resulting in glomerular injury. LN often concomitantly affects the tubulointerstitial compartment of the kidney, leading first to interstitial inflammation and subsequently to interstitial fibrosis and atrophy of the renal tubules if not appropriately treated. Presently the only way to assess interstitial inflammation and fibrosis is through kidney biopsy, which is invasive and cannot be repeated frequently. Hence, monitoring of disease progression and response to therapy is suboptimal. In this paper we describe a mathematical model of the progress from tubulointerstitial inflammation to fibrosis. We demonstrate how the model can be used to monitor treatments for interstitial fibrosis in LN with drugs currently being developed or used for nonrenal fibrosis. PMID:25225370

Hao, Wenrui; Rovin, Brad H; Friedman, Avner

2014-09-30

150

Imaging of Childhood Interstitial Lung Disease  

PubMed Central

The aphorism that children are not little adults certainly applies for the imaging of interstitial lung disease. Acquiring motion-free images of fine pulmonary structures at desired lung volumes is much more difficult in children than in adults. Several forms of interstitial lung disease are unique to children, and some forms of interstitial lung disease encountered in adults rarely, if ever, occur in children. Meticulous attention to imaging technique and specialized knowledge are required to properly perform and interpret chest imaging studies obtained for the evaluation of childhood interstitial lung disease (chILD). This review will address technique recommendations for imaging chILD, the salient imaging findings in various forms of chILD, and the efficacy of imaging in the diagnosis and management of chILD. PMID:22332031

2010-01-01

151

Granular Material Flows with Interstitial Fluid Effects.  

National Technical Information Service (NTIS)

The research focused on experimental measurements of the rheological properties of liquid-solid and granular flows. In these flows, the viscous effects of the interstitial fluid, the inertia of the fluid and particles, and the collisional interactions of ...

M. L. Hunt, C. E. Brennen

2004-01-01

152

Toxicity Associated With Bowel or Bladder Puncture During Gynecologic Interstitial Brachytherapy  

SciTech Connect

Purpose: Interstitial brachytherapy for gynecologic malignancies is associated with significant toxicity. Some reports have correlated this toxicity with needle puncture of the visceral organs. This study examined our experience with interstitial brachytherapy and investigated the relationship between the visceral puncture and toxicity. Methods and Materials: The outcomes of 36 patients treated with interstitial brachytherapy for gynecologic malignancies at a single institution between 2002 and 2007 were reviewed. Computed tomography was used to guide needle placement based solely on tumor coverage. No attempts were made to avoid visceral puncture; however, the source dwell times were minimized in these areas. Results: At a median follow-up of 21 months, the crude locoregional control rate was 78%. Bowel puncture was noted in 26 patients and bladder puncture in 19. The mean operating time was 50 min, and 86% of patients were discharged in <=3 days. The incidence of acute and late toxicity was similar between patients with and without visceral puncture according to the log-rank analysis of Kaplan-Meier curves. No patients with bowel puncture experienced Grade 2 or greater acute gastrointestinal toxicity and only 1 had Grade 3 or greater late gastrointestinal toxicity. No patients with bladder puncture experienced greater than Grade 2 acute genitourinary toxicity and only 2 had late Grade 3 or greater genitourinary toxicity. Conclusion: The operating time, length of hospital stay, and treatment-induced morbidity in this cohort compared favorably to series using techniques to avoid visceral puncture. Additionally, visceral puncture did not correlate with the occurrence of acute or late toxicity. These data suggest that visceral puncture in the absence of source loading carries a low risk of morbidity.

Shah, Anand P., E-mail: Anand_Shah@rush.ed [Department of Radiation Oncology, Rush University, Chicago, IL (United States); Strauss, Jonathan B.; Gielda, Benjamin T.; Zusag, Thomas W. [Department of Radiation Oncology, Rush University, Chicago, IL (United States)

2010-05-01

153

Current status of idiopathic nonspecific interstitial pneumonia.  

PubMed

Pulmonary pathologists were aware of cases of idiopathic interstitial pneumonia (IIP) that morphologically did not fit Liebow's classification scheme. These cases were labeled as "cellular interstitial pneumonia" or "chronic interstitial pneumonia not otherwise specified." The term nonspecific interstitial pneumonia (NSIP) was first used in relation to a pattern of lung interstitial inflammation seen in association with human immunodeficiency virus (HIV) infection. In 1994 NSIP was used to indicate a group of subacute or chronic interstitial pneumonias characterized morphologically by interstitial inflammation or fibrosis or both, with preservation of the lung architecture and the absence of typical findings for any of the other main categories of IIP (mainly usual interstitial pneumonia, desquamative interstitial pneumonia, and bronchiolitis obliterans organizing pneumonia). Although these patients presented with "nonspecific" lung histology (categorized as cellular and fibrotic variants), and with a broad spectrum of associated clinical conditions, such as connective tissue diseases (CTDs), environmental exposure, and previous acute lung injury, they showed some peculiar clinical aspects, including favorable response to corticosteroid treatment and overall good prognosis.The clinical and radiographic profiles were better defined in the last decade. The NSIP pattern is the histological background of a subacute/chronic interstitial pneumonitis that may be observed in many conditions, including CTD, drug-induced lung disease, hypersensitivity pneumonitis, slowly healing diffuse alveolar damage (DAD), relapsing organizing pneumonia, occupational exposure, immunodeficiency (mainly HIV infection), graft versus host disease (GVHD), familial pulmonary fibrosis, immunoglobulin G4 (IgG4)-related sclerosing disease, with or without overlap features with Rosai-Dorfman disease, multicentric Castleman disease, and myelodysplastic syndrome. Rarely, NSIP is the histology recognized in patients with idiopathic interstitial pneumonitis, in whom efforts to find potential causative exposures are futile. This entity occurs mostly in middle-aged, never-smoker women, with a likely association with an autoimmune background. High-resolution computed tomographic (HRCT) scans typically demonstrate ground-glass attenuation with a bibasilar distribution, or in the fibrotic variant, ground-glass attenuation along with reticular lines and traction bronchiectasis. The prognosis is good compared with idiopathic pulmonary fibrosis (IPF), and therapeutic options include mainly corticosteroids and immunosuppressive agents. Recently a more precise definition of clinical profiles and radiographic findings of idiopathic NSIP allows consideration of less invasive diagnostic procedures (bronchoalveolar lavage, transbronchial lung biopsy). Better understanding of pathogenetic mechanisms might widen the therapeutic horizon giving a role to new therapeutic options in more severe cases. PMID:23001799

Poletti, Venerino; Romagnoli, Micaela; Piciucchi, Sara; Chilosi, Marco

2012-10-01

154

Energetics of formation and migration of self-interstitials and self-interstitial clusters in ?-iron  

NASA Astrophysics Data System (ADS)

Energetic primary recoil atoms from fast neutron irradiation generate both isolated point defects and clusters of vacancies and interstitials. Self-interstitial mobility as well as defect cluster stability and mobility play key roles in the subsequent fate of defects and, hence, in the overall microstructural evolution under irradiation. Self-interstitials and two, three and four-member self-interstitial clusters are highly mobile at low temperatures as observed in molecular-dynamics simulations and high mobility probably also extends to larger clusters. In this study, the morphology, energetics and mobility of self-interstitials and small self-interstitial clusters in ?-iron are studied by molecular-statics and molecular-dynamics simulations using a Finnis-Sinclair many-body interatomic potential. Self-interstitial migration is found to be a two-step process consisting of a rotation out of the <110> split-dumbbell configuration into the <111> split-dumbbell configuration and <111> translational jumps through the crowdion configuration before returning to the <110> dumbbell configuration. Self-interstitial clusters of <111> type split-interstitials assembled on adjacent {110} planes migrate along <111> directions in an amoeba-like fashion by sequential local dissociation and re-association processes.

Wirth, B. D.; Odette, G. R.; Maroudas, D.; Lucas, G. E.

1997-04-01

155

Lupus-erythematous-associated interstitial granulomatous dermatitis.  

PubMed

A 41-year-old woman with a prior diagnosis of lupus erythematous presented with a five-year history of small, erythematous, flesh-colored papules and nodules that coalesced into symmetrically-distributed plaques on her upper back. A biopsy specimen showed an interstitial, granulomatous mixed-cell dermatitis with eosinophils. These clinicopathologic findings are consistent with a diagnosis of lupus erythematous-associated interstitial granulomatous dermatitis. PMID:23286821

Marmon, Shoshana; Robinson, Maria; Meehan, Shane A; Franks, Andrew G

2012-12-01

156

Interstitial Granulomatous Dermatitis: Another Clinical Variant  

Microsoft Academic Search

A 70-year-old female patient presented with an eruption consisting of symmetrically distributed erythematous papules around the umbilicus 1 month after the cessation of adalimumab for the treatment of rheumatoid arthritis. Biopsy of a papule showed an interstitial granulomatous infiltrate in the dermis, without deposition of mucin. The lesions cleared only after re-initiation of treatment 2 months later. Interstitial granulomatous dermatitis

Aikaterini Patsatsi; Aikaterini Kyriakou; Eva Triantafyllidou; Dimitrios Sotiriadis

2011-01-01

157

Buffon's Needle: An Analysis and Simulation  

NSDL National Science Digital Library

Created by George Reese of the University of Illinois at Urbana-Champaign, this resource gives some background on the Buffon's needle problem. The site provides a link to an applet that allows one to simulate dropping a needle once, ten times, one-hundred times, or one-thousand times. One also has control over the length of the needle. Aside from the applet, the author provides an introduction, the simplest case, other cases, a brief series of questions and references. This is a nice case study of one statistical problem.

Reese, George

2009-02-23

158

Automatic Steering of Manually Inserted Needles  

PubMed Central

Bevel-tipped flexible needles can be robotically steered to reach clinical targets along curvilinear paths in 3D. Manual needle insertion allows the clinician to control the insertion speed, ensuring patient safety. This paper presents a control law for automatic 3D steering of manually inserted flexible needles, enabling path-following control. A look-ahead proportional controller for position and orientation is presented. The look-ahead distance is a linear function of insertion speed. Simulations in a 3D brain-like environment demonstrate the performance of the proposed controller. Experimental results also show the feasibility of this technique in 2D and 3D environments. PMID:24752485

Wu, Guofan; Li, Xiao; Lehocky, Craig A.; Riviere, Cameron N.

2014-01-01

159

Needle-Tissue Interaction Forces for Bevel-Tip Steerable Needles  

PubMed Central

The asymmetry of a bevel-tip needle results in the needle naturally bending when it is inserted into soft tissue. As a first step toward modeling the mechanics of deflection of the needle, we determine the forces at the bevel tip. In order to find the forces acting at the needle tip, we measure rupture toughness and nonlinear material elasticity parameters of several soft tissue simulant gels and chicken tissue. We incorporate these physical parameters into a finite element model that includes both contact and cohesive zone models to simulate tissue cleavage. We investigate the sensitivity of the tip forces to tissue rupture toughness, linear and nonlinear tissue elasticity, and needle tip bevel angle. The model shows that the tip forces are sensitive to the rupture toughness. The results from these studies contribute to a mechanics-based model of bevel-tip needle steering, extending previous work on kinematic models. PMID:22020139

Misra, Sarthak; Reed, Kyle B.; Douglas, Andrew S.; Ramesh, K. T.; Okamura, Allison M.

2010-01-01

160

Modeling of Needle Steering via Duty-Cycled Spinning  

Microsoft Academic Search

As flexible bevel tip needles are inserted into tissue, a deflection force causes the needle to bend with a curvature dependent on relative stiffness and bevel angle. By constantly spinning the needle during insertion, the bevel angle is essentially negated and a straight trajectory can be achieved. Incorporating duty-cycled spinning during needle insertion provides proportional control of the curvature of

Davneet S. Minhas; Johnathan A. Engh; Michele M. Fenske; Cameron N. Riviere

2007-01-01

161

Sliding Mode Control of Steerable Needles  

PubMed Central

Steerable needles can potentially increase the accuracy of needle-based diagnosis and therapy delivery, provided they can be adequately controlled based on medical image information. We propose a novel sliding mode control law that can be used to deliver the tip of a flexible asymmetric-tipped needle to a desired point, or to track a desired trajectory within tissue. The proposed control strategy requires no a priori knowledge of model parameters, has bounded input speeds, and requires little computational resources. We show that if the standard nonholonomic model for tip-steered needles holds, then the control law will converge to desired targets in a reachable workspace, within a tolerance that can be defined by the control parameters. Experimental results validate the control law for target points and trajectory following in phantom tissue and ex vivo liver. Experiments with targets that move during insertion illustrate robustness to disturbances caused by tissue deformation. PMID:25400527

Rucker, D. Caleb; Das, Jadav; Gilbert, Hunter B.; Swaney, Philip J.; Miga, Michael I.; Sarkar, Nilanjan; Webster, Robert J.

2014-01-01

162

Lifetime needle sharing: a predictive analysis.  

PubMed

Through understanding predictors of needle sharing, it may be possible to design AIDS prevention interventions more effectively. Data were collected from a sample of 416 patients in two New York City methadone programs in 1990. Questions were asked about needle sharing and about a battery of predictors covering 11 psychosocial domains. Based on factor analysis, these were reduced to seven factors: criminal history, antisocial characteristics, social integration, severity of psychiatric problems, current drug involvement, physical health, and personality disorders. Bivariate analyses showed that criminal involvement, antisocial characteristics, social integration, and age were significantly related to needle sharing. With the seven factors, as well as age, gender, and ethnicity simultaneously examined by means of regression analysis, it was found that criminal involvement, severity of psychiatric problems, and age were all positively associated with needle sharing. Implications for treatment are discussed. PMID:7869466

Kleinman, P H; Millman, R B; Robinson, H; Lesser, M; Hsu, C; Engelhart, P; Finkelstein, I

1994-01-01

163

Intradermal needle-free powdered drug injection  

E-print Network

This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis ...

Liu, John (John Hsiao-Yung)

2012-01-01

164

Needle cathodes for high-brightness beams  

NASA Astrophysics Data System (ADS)

At the tips of sharp needles, the surface electric field is enhanced by many orders of magnitude. This intensifies thermionic emission and photoemission of electrons through the Schottky effect, and reduces the effect of space charge. The increased current density improves the brightness of electron sources by orders of magnitude. In addition, at very high fields (>109 V/m), field emission and photo-field emission produce very high current density. Arrays of needles can be used to achieve high total current.

Boulware, C. H.; Jarvis, J. D.; Andrews, H. L.; Brau, C. A.

2007-09-01

165

Needle Cathodes for High-Brightness Beams  

NASA Astrophysics Data System (ADS)

At the tips of sharp needles, the surface electric field is enhanced by many orders of magnitude. This intensifies thermionic emission and photoemission of electrons through the Schottky effect, and reduces the effect of space charge. The increased current density improves the brightness of electron sources by orders of magnitude. In addition, at very high fields (>109 V/m), field emission and photo-field emission produce very high current density. Arrays of needles can be used to achieve high total current.

Boulware, C. H.; Jarvis, J. D.; Andrews, H. L.; Brau, C. A.

166

One-dimensional gas of hard needles  

E-print Network

We study a one dimensional gas of needle-like objects as a testing ground for a formalism that relates the thermodynamic properties of "hard" potentials to the probabilities for contacts between particles. Specifically, we use Monte Carlo methods to calculate the pressure and elasticity coefficient of the hard-needle gas as a function of its density. The results are then compared to the same quantities obtained analytically from a transfer matrix approach.

Yacov Kantor; Mehran Kardar

2009-02-11

167

Finite element model of needle electrode sensitivity  

NASA Astrophysics Data System (ADS)

We used the Finite Element (FE) Method to estimate the sensitivity of a needle electrode for bioimpedance measurement. This current conducting needle with insulated shaft was inserted in a saline solution and current was measured at the neutral electrode. FE model resistance and reactance were calculated and successfully compared with measurements on a laboratory model. The sensitivity field was described graphically based on these FE simulations.

Høyum, P.; Kalvøy, H.; Martinsen, Ø. G.; Grimnes, S.

2010-04-01

168

Trigger point needling: techniques and outcome.  

PubMed

In this review we provide the updates on last years' advancements in basic science, imaging methods, efficacy, and safety of dry needling of myofascial trigger points (MTrPs). The latest studies confirmed that dry needling is an effective and safe method for the treatment of MTrPs when provided by adequately trained physicians or physical therapists. Recent basic studies have confirmed that at the site of an active MTrP there are elevated levels of inflammatory mediators, known to be associated with persistent pain states and myofascial tenderness and that this local milieu changes with the occurrence of local twitch response. Two new modalities, sonoelastography and magnetic resonance elastography, were recently introduced allowing noninvasive imaging of MTrPs. MTrP dry needling, at least partially, involves supraspinal pain control via midbrain periaqueductal gray matter activation. A recent study demonstrated that distal muscle needling reduces proximal pain by means of the diffuse noxious inhibitory control. Therefore, in a patient too sensitive to be needled in the area of the primary pain source, the treatment can be initiated with distal needling. PMID:22610507

Vulfsons, Simon; Ratmansky, Motti; Kalichman, Leonid

2012-10-01

169

[A brief analysis of taking off the needle slowly].  

PubMed

The ancients highlight taking off the needle slowly. From aspects of proper timing of withdrawing the needle, the safe treatment, treating and keeping the spirit, dealing with the acupuncture accidents, reinforcing and reducing manipulation and strengthening the post-needling sensation, etc. advantages of taking off the needle slowly are described in this paper. So the taking off the needle slowly is worthwhile in clinic. PMID:23885615

Zhu, An-Ning; Meng, Xian-Jun; Feng, Dan-Dan

2013-05-01

170

Technical basis and proposal for deriving sediment quality criteria for metals  

Microsoft Academic Search

In developing sediment quality criteria (SQC) for metals, it is essential that bioavailability be a prime consideration. Different studies have shown that while dry weight metal concentrations in sediments are not predictive of bioavailability, metal concentrations in interstitial (pore) water are correlated with observed biological effects. A key partitioning phase controlling cationic metal activity and toxicity in the sediment-interstitial water

Gerald T. Ankley; Dominic M. Di Toro; David J. Hansen; Walter J. Berry

1996-01-01

171

The significance of interstitial cells in neurogastroenterology.  

PubMed

Smooth muscle layers of the gastrointestinal tract consist of a heterogeneous population of cells that include enteric neurons, several classes of interstitial cells of mesenchymal origin, a variety of immune cells and smooth muscle cells (SMCs). Over the last number of years the complexity of the interactions between these cell types has begun to emerge. For example, interstitial cells, consisting of both interstitial cells of Cajal (ICC) and platelet-derived growth factor receptor alpha-positive (PDGFR?(+)) cells generate pacemaker activity throughout the gastrointestinal (GI) tract and also transduce enteric motor nerve signals and mechanosensitivity to adjacent SMCs. ICC and PDGFR?(+) cells are electrically coupled to SMCs possibly via gap junctions forming a multicellular functional syncytium termed the SIP syncytium. Cells that make up the SIP syncytium are highly specialized containing unique receptors, ion channels and intracellular signaling pathways that regulate the excitability of GI muscles. The unique role of these cells in coordinating GI motility is evident by the altered motility patterns in animal models where interstitial cell networks are disrupted. Although considerable advances have been made in recent years on our understanding of the roles of these cells within the SIP syncytium, the full physiological functions of these cells and the consequences of their disruption in GI muscles have not been clearly defined. This review gives a synopsis of the history of interstitial cell discovery and highlights recent advances in structural, molecular expression and functional roles of these cells in the GI tract. PMID:24948131

Blair, Peter J; Rhee, Poong-Lyul; Sanders, Kenton M; Ward, Sean M

2014-07-31

172

Formation of stable sessile interstitial complexes in reactions between glissile dislocation loops in bcc Fe  

NASA Astrophysics Data System (ADS)

Clusters of self-interstitial atoms (loops) are commonly observed in the microstructure of irradiated metals. These clusters can be formed directly in high-energy displacement cascades or by growth as a result of interaction between individual self interstitials. The majority of these clusters have features of glissile dislocation loops and migrate by fast one-dimensional glide. In this paper, we present results of a systematic molecular dynamics (MD) study of reactions involving glissile interstitial loops. By the example of bcc iron we demonstrate that the reactions can produce a number of specific, stable microstructural features, with different properties compared to the reactants. Namely, the reactions between the most common glissile clusters of <1 1 1> crowdions can result in coarsening or formation of immobile self interstitial complexes. The coarsening leads to a decrease of the total dislocation line length and therefore is favourable. The structure and stability of the junction formed in the reactions has been studied using many-body potentials and density functional theory (DFT) techniques. No evidence of the formation of a <1 0 0> loop from two glissile <1 1 1> clusters was found among the studied reactions. The immobile self interstitial complexes that form as a result of these reaction have, however, high binding energies, of the order of tens of eV, implying that a relatively long life time should be assigned to the resulting configurations and therefore that such objects are expected to contribute to the evolution of the microstructure under irradiation.

Terentyev, Dmitry; Malerba, Lorenzo; Klaver, Peter; Olsson, Par

2008-12-01

173

An overview of interstitial brachytherapy and hyperthermia  

SciTech Connect

Interstitial thermoradiotherapy, an experimental cancer treatment that combines interstitial radiation implants (brachytherapy) and interstitial hyperthermia, is in the early stages of investigation. In accordance with the procedure used in a current national trial protocol, a 60-minute hyperthermia treatment is administered after catheters are placed into the tumor area while the patient is under general anesthesia. This is immediately followed by loading of radioactive Iridium-192 seeds into the catheters for a defined period of time. Once the prescribed radiation dose is delivered, the radioactive sources are removed and a second, 60-minute hyperthermia treatment is administered. Clinical trials with hyperthermia in combination with radiation have increased in recent years. Nurses caring for these patients need to become more knowledgeable about this investigational therapy. This paper provides an overview of the biologic rationale for this therapy, as well as a description of the delivery method and clinical application. Specific related nursing interventions are defined in a nursing protocol.23 references.

Brandt, B.B.; Harney, J.

1989-11-01

174

Interstitial granulomatous dermatitis secondary to soy.  

PubMed

A healthy 58-year-old woman developed an asymptomatic papular eruption of the neck, cheek, abdomen, arms, and flexures. There was an 8-year history of the lesions, which had erupted when the patient started a strict vegetarian diet. Lesions lasted 3 to 5 days, cleared without scarring, and were associated with burning and increased tearing of the eyes. The biopsy specimen showed an interstitial granulomatous dermatitis without vascular injury, collagen alteration, or mononuclear atypia. The eruption cleared when the patient omitted soy products from her diet. It subsequently recurred with intake of even minimal amounts of soy. Interstitial granulomatous dermatitis is a histologic pattern of inflammation that generates a broad differential diagnosis. No previous reports of interstitial granulomatous dermatitis related to soy products are available in the literature. PMID:15280826

Dyson, Senait W; Hirsch, Ann; Jaworsky, Christine

2004-08-01

175

Interstitial granulomatous dermatitis: another clinical variant.  

PubMed

A 70-year-old female patient presented with an eruption consisting of symmetrically distributed erythematous papules around the umbilicus 1 month after the cessation of adalimumab for the treatment of rheumatoid arthritis. Biopsy of a papule showed an interstitial granulomatous infiltrate in the dermis, without deposition of mucin. The lesions cleared only after re-initiation of treatment 2 months later. Interstitial granulomatous dermatitis is thought to be a distinct histopathological pattern, either drug induced or associated with rheumatoid arthritis or autoimmune collagen diseases. In our case, there was a distinct clinical presentation of interstitial granulomatous dermatitis, composed of symmetrically distributed indurated papules around the umbilicus as well as a mild granulomatous reaction pattern. PMID:22087092

Patsatsi, Aikaterini; Kyriakou, Aikaterini; Triantafyllidou, Eva; Sotiriadis, Dimitrios

2011-09-01

176

Needle retention, needle density and growth rate of Scots pine (Pinus sylvestris L.)  

Microsoft Academic Search

A method (NTM - needle trace method) created and developed by the Finnish forest pathologists T. Kurkela, R. Jalkanen and T. Aalto gave a new modus for learning of different aspects of the life of perennial needles, and, indirectly, of the whole tree. This laborious method was put to the test, in this article as a part of research training

Rein Drenkhan

177

Transbronchial needle aspiration with a new electromagnetically-tracked TBNA needle  

NASA Astrophysics Data System (ADS)

Transbronchial needle aspiration (TBNA) is a common method used to collect tissue for diagnosis of different chest diseases and for staging lung cancer, but the procedure has technical limitations. These limitations are mostly related to the difficulty of accurately placing the biopsy needles into the target mass. Currently, pulmonologists plan TBNA by examining a number of Computed Tomography (CT) scan slices before the operation. Then, they manipulate the bronchoscope down the respiratory track and blindly direct the biopsy. Thus, the biopsy success rate is low. The diagnostic yield of TBNA is approximately 70 percent. To enhance the accuracy of TBNA, we developed a TBNA needle with a tip position that can be electromagnetically tracked. The needle was used to estimate the bronchoscope's tip position and enable the creation of corresponding virtual bronchoscopic images from a preoperative CT scan. The TBNA needle was made with a flexible catheter embedding Wang Transbronchial Histology Needle and a sensor tracked by electromagnetic field generator. We used Aurora system for electromagnetic tracking. We also constructed an image-guided research prototype system incorporating the needle and providing a user-friendly interface to assist the pulmonologist in targeting lesions. To test the feasibility of the accuracy of the newly developed electromagnetically-tracked needle, a phantom study was conducted in the interventional suite at Georgetown University Hospital. Five TBNA simulations with a custom-made phantom with a bronchial tree were performed. The experimental results show that our device has potential to enhance the accuracy of TBNA.

Choi, Jae; Popa, Teo; Gruionu, Lucian

2009-02-01

178

Gas chromatography analysis of benzene, toluene, ethylbenzene and xylenes using newly designed needle trap device in aqueous samples.  

PubMed

A newly designed needle trap device with Carbopack X as a sorbent material is used for sampling, preconcentration and injection of volatile analytes benzene, toluene, ethylbenzene and xylenes (BTEX) into gas chromatograph. The closed system of stripping the analytes from water samples was used. An injection port with a modified metal liner was used to desorb analytes trapped in needle trap device. The main advantage of needle trap device consists in the simple methodology and easiness and rapidity of the analysis. Needle trap device is suitable for sampling in field. The experimental parameters as breakthrough volume of stripping gas, linearity, repeatability and limit of detection (LOD) and quantification (LOQ) were investigated. LOD ranges from 0.05 to 0.07 microgL(-1) and relative standard deviation ranges from 0.5% to 11.6% at concentrations 5 and 0.1 microgL(-1), respectively. PMID:18495138

Jurdáková, Helena; Kubinec, Róbert; Jurcisinová, Mária; Krkosová, Zofia; Blasko, Jaroslav; Ostrovský, Ivan; Soják, Ladislav; Berezkin, Victor G

2008-06-20

179

Modeling of Needle-Tissue Interaction Forces During Surgical Suturing  

PubMed Central

This paper presents a model of needle tissue interaction forces that a rigid suture needle experiences during surgical suturing. The needle-tissue interaction forces are modeled as the sum of lumped parameters. The model has three main components; friction, tissue compression, and cutting forces. The tissue compression force uses the area that the needle sweeps out during a suture to estimate both the force magnitude and force direction. The area that the needle sweeps out is a direct result of driving the needle in a way that does not follow the natural curve of the needle. The friction force is approximated as a static friction force along the shaft of the needle. The cutting force acts only on the needle tip. The resulting force and torque model is experimentally validated using a tissue phantom. These results indicate that the proposed lumped parameter model is capable of accurately modeling the forces experienced during a suture. PMID:24683499

Jackson, Russell C.; Cavusoglu, M. Cenk

2013-01-01

180

Characterization of Pre-Curved Needles for Steering in Tissue  

PubMed Central

Needles with tip asymmetry deflect upon insertion into soft tissue, an effect that can be used to steer needles within the body. This paper presents a phenomenological characterization of the steering behavior of pre-curved needles, which have tip asymmetry due to curvature of the needle near the tip. We describe needle construction methods and a needle shaft triangulation algorithm to compute the shape of the needle based on images. Experimental results show that pre-curved needles possess greater dexterity than bevel-tipped needles and achieve radii of curvature similar to pre-bent needles. For long pre-curve arc lengths, the radius of curvature of the needle was found to approach the radius of curvature of the pre-curve. Pre-curved needles were found to display behaviors not seen with bevel-tipped needles, such as the insertion velocity influencing the path of the tip within the tissue and the ability to plastically deform the needle during steering. PMID:19963994

Wedlick, Thomas R.; Okamura, Allison M.

2010-01-01

181

Medically relevant ElectroNeedle technology development.  

SciTech Connect

ElectroNeedles technology was developed as part of an earlier Grand Challenge effort on Bio-Micro Fuel Cell project. During this earlier work, the fabrication of the ElectroNeedles was accomplished along with proof-of-concept work on several electrochemically active analytes such as glucose, quinone and ferricyanide. Additionally, earlier work demonstrated technology potential in the field of immunosensors by specifically detecting Troponin, a cardiac biomarker. The current work focused upon fabrication process reproducibility of the ElectroNeedles and then using the devices to sensitively detect p-cresol, a biomarker for kidney failure or nephrotoxicity. Valuable lessons were learned regarding fabrication assurance and quality. The detection of p-cresol was accomplished by electrochemistry as well as using fluorescence to benchmark ElectroNeedles performance. Results from these studies will serve as a guide for the future fabrication processes involving ElectroNeedles as well as provide the groundwork necessary to expand technology applications. One paper has been accepted for publication acknowledging LDRD funding (K. E. Achyuthan et al, Comb. Chem. & HTS, 2008). We are exploring the scope for a second paper describing the applications potential of this technology.

Schmidt, Carrie Frances; Thomas, Michael Loren; McClain, Jaime L.; Harper, Jason C.; Achyuthan, Komandoor E.; Ten Eyck, Gregory A.

2008-11-01

182

Computer-assisted interstitial laser coagulation for BPH  

NASA Astrophysics Data System (ADS)

Interstitial laser thermotherapy is a minimally invasive surgical procedure that utilizes laser to coagulate and treat benign prostatic hyperplasia. This study explores the use of a computer-assisted interstitial laser coagulation system to aid surgeons in performing this procedure.

Ho, Gideon; Barrett, Adrian R. W.; Ng, Wan S.; Lim, Liam G.; Cheng, Wai S.

2001-06-01

183

Interstitial photodynamic laser therapy in interventional oncology  

Microsoft Academic Search

Photodynamic therapy (PDT) is a well-investigated locoregional cancer treatment in which a systemically administered photosensitizer is activated locally by illuminating the diseased tissue with light of a suitable wavelength. PDT offers various treatment strategies in oncology, especially palliative ones. This article focuses on the development and evaluation of interstitial PDT for the treatment of solid tumors, particularly liver tumors. The

Thomas J. Vogl; Katrin Eichler; Martin G. Mack; Stephan Zangos; Christopher Herzog; Axel Thalhammer; Kerstin Engelmann

2004-01-01

184

Treatment of interstitial lung disease in children  

Microsoft Academic Search

The treatment of interstitial lung disease in children depends on the nature of the underlying pathology. In approximately 50% of cases a specific aetiology can be found such as: chronic viral infection, an auto-immune process, sarcoidosis or alveolar proteinosis. In the remainder, the process is idiopathic and the pathological findings are based on the descriptive morphological features seen in the

R Dinwiddie

2004-01-01

185

Carbamazepine-induced acute granulomatous interstitial nephritis.  

PubMed

A 79-year-old man, newly started on carbamazepine, presented with rash, eosinophilia and liver dysfunction progressing to acute renal failure despite discontinuation of the anti-epileptic agent. Percutaneous renal biopsy revealed acute granulomatous interstitial nephritis, which responded successfully to high-dose oral steroid therapy. PMID:12005248

Hegarty, J; Picton, M; Agarwal, G; Pramanik, A; Kalra, P A

2002-04-01

186

Interstitial granulomatous dermatitis with plaques and arthritis.  

PubMed

Interstitial granulomatous dermatitis and arthritis (IGDA) is a rare disease entity with female predominance. The case of a 53-year-old woman with erythemas, plaques and nodules associated with polyarthritis is presented. She was treated with cyclosporin A, with improvement of the joint affliction and complete clearance of skin lesions. The differential diagnosis of IGDA is discussed briefly. PMID:14579165

Wollina, U; Schönlebe, J; Unger, L; Weigel, K; Köstler, E; Nüsslein, H

2003-10-01

187

Interstitial granulomatous dermatitis with plaques and arthritis  

Microsoft Academic Search

Interstitial granulomatous dermatitis and arthritis (IGDA) is a rare disease entity with female predominance. The case of a 53-year-old woman with erythemas, plaques and nodules associated with polyarthritis is presented. She was treated with cyclosporin A, with improvement of the joint affliction and complete clearance of skin lesions. The differential diagnosis of IGDA is discussed briefly.

U. Wollina; J. Schönlebe; L. Unger; K. Weigel; E. Köstler; H. Nüsslein

2003-01-01

188

Interstitial Laser Therapy of Benign Prostatic Hyperplasia  

Microsoft Academic Search

The objective of interstitial laser coagulation (ILC) of benign prostatic enlargement is to achieve a marked volume reduction and to decrease bladder outlet obstruction and lower urinary tract symptoms with minimal morbidity. Coagulation necrosis is generated well inside the adenoma by means of specifically designed laser applicators combined with either a Nd:YAG laser or a diode laser. Because the laser

Rolf Muschter; Hugh Whitfield

1999-01-01

189

Interstitial deletion of chromosome 15: two cases  

Microsoft Academic Search

Two cases of interstitial deletion of chromosome 15 with similar clinical features are presented. In one case, assay of hexosaminidase A enabled us to confirm that the structural gene is located between 15q22 and 15q25 and that it is included in the deletion.

L. de F. Formiga; L. Poenaru; F. Couronne; E. Flori; J. L. Eibel; M. M. Deminatti; J. B. Savary; J. L. Lai; S. Gilgenkrantz; M. Pierson

1988-01-01

190

Interstitial fibrosis: tubular hypothesis versus glomerular hypothesis  

Microsoft Academic Search

The pathogenesis of renal interstitial fibrosis leading eventually to renal failure is highly debatable. Whereas the so-called tubular hypothesis, involving an increased tubular uptake of potentially toxic substances that induce a variety of cytokines, growth factors, and profibrogenic factors, is based to a large extent on cell-culture studies, the glomerular hypothesis is based mainly on careful morphological observations. Unraveling the

Erik I Christensen; Pierre J Verroust

2008-01-01

191

The management of interstitial cystitis: an update  

Microsoft Academic Search

Treating interstitial cystitis (IC) is one of the greatest challenges facing physicians and other health care providers who manage patients with this condition. The symptoms of urinary frequency and urgency, dysuria, and chronic pelvic pain characterize IC, but it is the debilitating pelvic pain associated with IC that is most difficult to control. The pathophysiology of IC pain is poorly

Sagar Phatak; Harris E Foster Jr

2006-01-01

192

A new miniature x-ray source for interstitial radiosurgery: device description.  

PubMed

A device that generates low-energy x rays at the tip of a needle-like probe was developed for stereotactic interstitial radiosurgery. Electrons from a small thermionic gun are accelerated to a final energy of up to 40 keV and directed along a 3 mm outside diameter drift tube to a thin Au target, where the beam size is approximately 0.3 mm. All high-voltage electronics are in the probe housing, connected by low-voltage cable to a battery-operated control box. X-ray output, which is nearly isotropic, consists of a bremsstrahlung spectrum and several lines between 7 and 14 keV, with characteristic radiation contributing 15% of the total energy output. To date, 14 patients with metastatic brain tumors have been treated with this device. PMID:8700032

Dinsmore, M; Harte, K J; Sliski, A P; Smith, D O; Nomikos, P M; Dalterio, M J; Boom, A J; Leonard, W F; Oettinger, P E; Yanch, J C

1996-01-01

193

Computed tomography of diffuse interstitial lung disease in children.  

PubMed

Unlike diseases of the airways, interstitial lung diseases in childhood are exceedingly rare and are usually associated with significant morbidity and mortality. Interstitial lung disease in the paediatric age group is a particular diagnostic challenge because the clinical presentation and radiographic features are so non-specific. High resolution computed tomography (HRCT) has proved its worth in adults with interstitial lung disease and has a role, albeit more limited, in the non-invasive evaluation of paediatric interstitial lung disease. PMID:10988042

Koh, D M; Hansell, D M

2000-09-01

194

[A patient with desquamative interstitial pneumonia as a rare case of idiopathic interstitial pneumonia].  

PubMed

The idiopathic interstitial pneumonias are a heterogeneous group of diseases that have similar clinical symptoms. The new classification is based mainly on differences in histologic patterns, however high-resolution computed tomography is a significant tool that helps in making a firm diagnosis. Desquamative interstitial pneumonia is relatively rare form idiopathic interstitial pneumonia. It affects mainly men in their fourth or fifth decade of life who have a history of smoking. We report a case of 50-years-old man admitted to hospital for further diagnosis of prolonged bilateral pneumonia. His main complaints were fatigue, productive cough and subfebrile body temperature. Having performed additional diagnostic procedures including videothoracoscopy, what was in accordance with contemporary guidelines, we achieved a final diagnosis of desquamative interstitial pneumonia. Treatment with systemic corticosteroids resulted in disease remission. PMID:18843935

Gasior, Grzegorz; Barczyk, Adam; Drozdzowska, Bogna; Pierzcha?a, W?adys?aw

2008-01-01

195

Creeping Motion of Self Interstitial Atom Clusters in Tungsten  

PubMed Central

The formation and motion features of self interstitial atom (SIA) clusters in tungsten are studied by molecular dynamics (MD) simulations. The static calculations show that the SIA clusters are stable with binding energy over 2?eV. The SIA clusters exhibit a fast one dimensional (1D) motion along ?111?. Through analysis of the change of relative distance between SIAs, we find that SIAs jump in small displacements we call creeping motion, which is a new collective diffusion process different from that of iron. The potential energy surface of SIAs implicates that the creeping motion is due to the strong interaction between SIAs. These imply that several diffusion mechanism for SIA clusters can operate in BCC metals and could help us explore deep insight into the performance of materials under irradiation. PMID:24865470

Zhou, Wang Huai; Zhang, Chuan Guo; Li, Yong Gang; Zeng, Zhi

2014-01-01

196

Creeping Motion of Self Interstitial Atom Clusters in Tungsten  

NASA Astrophysics Data System (ADS)

The formation and motion features of self interstitial atom (SIA) clusters in tungsten are studied by molecular dynamics (MD) simulations. The static calculations show that the SIA clusters are stable with binding energy over 2 eV. The SIA clusters exhibit a fast one dimensional (1D) motion along <111>. Through analysis of the change of relative distance between SIAs, we find that SIAs jump in small displacements we call creeping motion, which is a new collective diffusion process different from that of iron. The potential energy surface of SIAs implicates that the creeping motion is due to the strong interaction between SIAs. These imply that several diffusion mechanism for SIA clusters can operate in BCC metals and could help us explore deep insight into the performance of materials under irradiation.

Zhou, Wang Huai; Zhang, Chuan Guo; Li, Yong Gang; Zeng, Zhi

2014-05-01

197

Creeping motion of self interstitial atom clusters in tungsten.  

PubMed

The formation and motion features of self interstitial atom (SIA) clusters in tungsten are studied by molecular dynamics (MD) simulations. The static calculations show that the SIA clusters are stable with binding energy over 2?eV. The SIA clusters exhibit a fast one dimensional (1D) motion along ?111?. Through analysis of the change of relative distance between SIAs, we find that SIAs jump in small displacements we call creeping motion, which is a new collective diffusion process different from that of iron. The potential energy surface of SIAs implicates that the creeping motion is due to the strong interaction between SIAs. These imply that several diffusion mechanism for SIA clusters can operate in BCC metals and could help us explore deep insight into the performance of materials under irradiation. PMID:24865470

Zhou, Wang Huai; Zhang, Chuan Guo; Li, Yong Gang; Zeng, Zhi

2014-01-01

198

Smoking-related idiopathic interstitial pneumonia.  

PubMed

Cigarette smoking is a key factor in the development of numerous pulmonary diseases. An international group of clinicians, radiologists and pathologists evaluated patients with previously identified idiopathic interstitial pneumonia (IIP) to determine unique features of cigarette smoking. Phase 1 (derivation group) identified smoking-related features in patients with a history of smoking (n=41). Phase 2 (validation group) determined if these features correctly predicted the smoking status of IIP patients (n=100) to participants blinded to smoking history. Finally, the investigators sought to determine if a new smoking-related interstitial lung disease phenotype could be defined. Phase 1 suggested that preserved forced vital capacity with disproportionately reduced diffusing capacity of the lung for carbon monoxide, and various radiographic and histopathological findings were smoking-related features. In phase 2, the kappa coefficient among clinicians was 0.16 (95% CI 0.11-0.21), among the pathologists 0.36 (95% CI 0.32-0.40) and among the radiologists 0.43 (95% CI 0.35-0.52) for smoking-related features. Eight of the 100 cases were felt to represent a potential smoking-related interstitial lung disease. Smoking-related features of interstitial lung disease were identified in a minority of smokers and were not specific for smoking. This study is limited by its retrospective design, the potential for recall bias in smoking history and lack of information on second-hand smoke exposure. Further research is needed to understand the relationship between smoking and interstitial lung disease. PMID:25063244

Flaherty, Kevin R; Fell, Charlene; Aubry, Marie-Christine; Brown, Kevin; Colby, Thomas; Costabel, Ulrich; Franks, Teri J; Gross, Barry H; Hansell, David M; Kazerooni, Ella; Kim, Dong Soon; King, Talmadge E; Kitachi, Masanori; Lynch, David; Myers, Jeff; Nagai, Sonoko; Nicholson, Andrew G; Poletti, Venerino; Raghu, Ganesh; Selman, Moises; Toews, Galen; Travis, William; Wells, Athol U; Vassallo, Robert; Martinez, Fernando J

2014-09-01

199

Hyaluronan in Tubular and Interstitial Nephrocalcinosis  

NASA Astrophysics Data System (ADS)

Hyaluronan (HA) is the major glycosaminoglycan (GAG) component of the renal medullary interstitium. HA is extremely large (up to 104 kDa) and composed of thousands repeating disaccharides of glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc). HA is synthesized by hyaluronan synthases (HASs) and degraded by hyaluronidases (Hyals). The production of HA by renomedullary interstitial cells is mediated by local osmolality. When excess water needs to be excreted, increased interstitial HA seems to antagonize water reabsorption, while the opposite occurs during water conservation. Hence, papillary interstitial HA is low and Hyal high during anti-diuresis, whereas during diuresis HA is high and Hyal low. The polyanion HA plays a role in the reabsorption of hypotonic fluid by immobilizing cations (Na+) via the carboxylate (COO-) groups of GlcUA. The binding of Ca2+ to anionic HA is probably also responsible for the fact that the papilla does not become a stone despite the extremely high interstitial phosphate and oxalate. HA is also an excellent crystal binding molecule. The expression of HA at the luminal surface of renal tubular cells leads to tubular nephrocalcinosis (tubular NC). Calcium staining methods (Von Kossa, Yasue) demonstrated that crystallization inhibitors cannot avoid the occasional precipitation of calcium phosphate in the papillary interstitium (interstitial NC). These crystals are probably immediately immobilized by the gel-like HA matrix. After ulcerating through the pelvic wall the calcified matrix becomes a Randall's plaque. The attachment of calcium oxalate crystals from the primary urine to plaque may ultimately lead to the development of clinical stones in the renal calyces (nephrolithiasis).

Verkoelen, Carl F.

2007-04-01

200

Identification of Early Interstitial Lung Disease in Smokers from the  

E-print Network

: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPFIdentification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans

201

REVIEW Open Access Interstitial lung diseases in children  

E-print Network

that affect alveolar walls. Typical features of ILD include dyspnea, diffuse infiltrates on chest radiographs features of ILD include the presence of diffuse infiltrates on chest radiograph, and abnormal pulmonary of idiopathic interstitial pneumonias: usual interstitial pneumonia (UIP), desquamative interstitial pneumonia

Paris-Sud XI, Université de

202

Phase Transformations during Spot Welding of InterstitialFree Steel  

E-print Network

the resistance spot­welding of interstitial­free steels are exceptionally problematic, not only because that form when interstitial free steels are resistance spot­welded. Interstitial­free steels do in reality­called body­in­white requires joining technologies, the most popular of which is resistance spot welding

Cambridge, University of

203

Mechanics of Flexible Needles Robotically Steered through Soft Tissue  

PubMed Central

The tip asymmetry of a bevel-tip needle results in the needle naturally bending when it is inserted into soft tissue. This enables robotic needle steering, which can be used in medical procedures to reach subsurface targets inaccessible by straight-line trajectories. However, accurate path planning and control of needle steering requires models of needle-tissue interaction. Previous kinematic models required empirical observations of each needle and tissue combination in order to fit model parameters. This study describes a mechanics-based model of robotic needle steering, which can be used to predict needle behavior and optimize system design based on fundamental mechanical and geometrical properties of the needle and tissue. We first present an analytical model for the loads developed at the tip, based on the geometry of the bevel edge and material properties of soft-tissue simulants (gels). We then present a mechanics-based model that calculates the deflection of a bevel-tipped needle inserted through a soft elastic medium. The model design is guided by microscopic observations of needle-gel interactions. The energy-based formulation incorporates tissue-specific parameters, and the geometry and material properties of the needle. Simulation results follow similar trends (deflection and radius of curvature) to those observed in experimental studies of robotic needle insertion. PMID:21170164

Misra, S.; Reed, K. B.; Schafer, B. W.; Ramesh, K. T.; Okamura, A. M.

2010-01-01

204

Teaching conventional transbronchial needle aspiration. A continuum.  

PubMed

Proponents of the endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) propose that in this era of EBUS-TBNA, training for conventional transbronchial needle aspiration (C-TBNA) should be abandoned. The authors of this editorial provide the opposing view. C-TBNA has a short and a steep learning curve and adds to the diagnostic yield of flexible bronchoscopy in a cost-effective fashion. Considering its simplicity, availability, affordability, safety, and several unique indications, C-TBNA continues to contribute to the welfare of patients worldwide. It should remain as an integral part of pulmonary fellowship training programs. PMID:24364773

Mehta, Atul C; Wang, Ko-Pen

2013-12-01

205

Syringe and Needle Size, Syringe Type, Vacuum Generation, and Needle Control in Aspiration Procedures  

SciTech Connect

Purpose: Syringes are used for diagnostic fluid aspiration and fine-needle aspiration biopsy in interventional procedures. We determined the benefits, disadvantages, and patient safety implications of syringe and needle size on vacuum generation, hand force requirements, biopsy/fluid yield, and needle control during aspiration procedures. Materials and Methods: Different sizes (1, 3, 5, 10, and 20 ml) of the conventional syringe and aspirating mechanical safety syringe, the reciprocating procedure device, were studied. Twenty operators performed aspiration procedures with the following outcomes measured: (1) vacuum (torr), (2) time to vacuum (s), (3) hand force to generate vacuum (torr-cm{sup 2}), (4) operator difficulty during aspiration, (5) biopsy yield (mg), and (6) operator control of the needle tip position (mm). Results: Vacuum increased tissue biopsy yield at all needle diameters (P < 0.002). Twenty-milliliter syringes achieved a vacuum of -517 torr but required far more strength to aspirate, and resulted in significant loss of needle control (P < 0.002). The 10-ml syringe generated only 15% less vacuum (-435 torr) than the 20-ml device and required much less hand strength. The mechanical syringe generated identical vacuum at all syringe sizes with less hand force (P < 0.002) and provided significantly enhanced needle control (P < 0.002). Conclusions: To optimize patient safety and control of the needle, and to maximize fluid and tissue yield during aspiration procedures, a two-handed technique and the smallest syringe size adequate for the procedure should be used. If precise needle control or one-handed operation is required, a mechanical safety syringe should be considered.

Haseler, Luke J., E-mail: l.haseler@griffith.edu.au [Griffith University, Heart Foundation Research Centre, Griffith Health Institute (Australia); Sibbitt, Randy R., E-mail: THESIBB2@aol.com [Montana Interventional and Dgnstc Radiation (United States); Sibbitt, Wilmer L., E-mail: wsibbitt@salud.unm.edu [University of New Mexico Health Sciences Center, Department of Internal Medicine (United States); Michael, Adrian A., E-mail: adrian_a_michael@yahoo.com [Texas Tech University Health Sciences Center, Department of Internal Medicine (United States); Gasparovic, Charles M., E-mail: chuck@unm.edu [University of New Mexico Health Sciences Center, MIND Institute at the University of New Mexico (United States); Bankhurst, Arthur D., E-mail: abankhurst@salud.unm.edu [University of New Mexico Health Sciences Center, Department of Internal Medicine (United States)

2011-06-15

206

Syringe and Needle Size, Syringe Type, Vacuum Generation, and Needle Control in Aspiration Procedures  

PubMed Central

Purpose Syringes are used for diagnostic fluid aspiration and fine needle aspiration biopsy (FNA) in interventional procedures. We determined the benefits, disadvantages, and patient safety implications of syringe and needle size on vacuum generation, hand force requirements, biopsy/fluid yield, and needle control during aspiration procedures. Materials and Methods Different sizes (1, 3, 5, 10, and 20 ml) of the conventional syringe and aspirating mechanical safety syringe, the reciprocating procedure device (RPD), were studied. 20 operators performed aspiration procedures with the following outcomes measured: 1) vacuum (Torr), 2) time to vacuum (seconds), 3) hand force to generate vacuum (Torr-cm2), 4) operator difficulty during aspiration, 5) biopsy yield (mg), and 6) operator control of the needle tip position (mm). Results Vacuum increased tissue biopsy yield at all needle diameters (p < 0.002). 20 ml syringes achieved a vacuum of ?517 Torr, but required significantly more strength to aspirate, and resulted in significant loss of needle control (p<0.002). The 10 ml syringe generated only 15% less vacuum (?435 Torr) than the 20 ml, and required much less hand strength. The mechanical syringe generated identical vacuum at all syringe sizes with less hand force (p<0.002), and provided significantly enhanced needle control (p<0.002). Conclusions To optimize patient safety and control of the needle and maximize fluid and tissue yield during aspiration procedures, a two-handed technique and the smallest syringe size adequate for the procedure should be used. If precise needle control or one-handed operation is required, a mechanical safety syringe should be considered. PMID:21057795

Haseler, Luke J.; Sibbitt, Randy R.; Sibbitt, Wilmer L.; Michael, Adrian A.; Gasparovic, Charles M.; Bankhurst, Arthur D.

2013-01-01

207

Radioactive Needlework Reconstruction of needle-positions in radiation treatment  

E-print Network

? More concretely: how to find the positions of these needles from distorted images from an ultrasound the shape and size of a firm walnut, and will be perforated by 12 to 30 needles. The access is through

Hochstenbach, Michiel

208

21 CFR 868.5090 - Emergency airway needle.  

Code of Federal Regulations, 2012 CFR

...needle. (a) Identification. An emergency airway needle is a device intended to puncture a patient's cricothyroid membrane to provide an emergency airway during upper airway obstruction. (b) Classification. Class II...

2012-04-01

209

21 CFR 868.5090 - Emergency airway needle.  

Code of Federal Regulations, 2011 CFR

...needle. (a) Identification. An emergency airway needle is a device intended to puncture a patient's cricothyroid membrane to provide an emergency airway during upper airway obstruction. (b) Classification. Class II...

2011-04-01

210

21 CFR 868.5090 - Emergency airway needle.  

Code of Federal Regulations, 2010 CFR

...needle. (a) Identification. An emergency airway needle is a device intended to puncture a patient's cricothyroid membrane to provide an emergency airway during upper airway obstruction. (b) Classification. Class II...

2010-04-01

211

21 CFR 868.5090 - Emergency airway needle.  

...needle. (a) Identification. An emergency airway needle is a device intended to puncture a patient's cricothyroid membrane to provide an emergency airway during upper airway obstruction. (b) Classification. Class II...

2014-04-01

212

21 CFR 868.5090 - Emergency airway needle.  

Code of Federal Regulations, 2013 CFR

...needle. (a) Identification. An emergency airway needle is a device intended to puncture a patient's cricothyroid membrane to provide an emergency airway during upper airway obstruction. (b) Classification. Class II...

2013-04-01

213

21 CFR 884.6100 - Assisted reproduction needles.  

Code of Federal Regulations, 2010 CFR

...884.6100 Assisted reproduction needles. (a) Identification. Assisted reproduction needles are devices used in in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), or other assisted reproduction procedures to obtain...

2010-04-01

214

Localized interstitial element analysis in defect regions of a near alpha titanium alloy fusion weld  

Microsoft Academic Search

This study was conducted on a fusion-welded specimen of Ti-6Al-2Nb-1Ta-0.8Mo to identify the cause of extensive cracking and porosity observed in the weld. Localized interstitial element measurements by nuclear reaction analysis techniques established that various regions in the weld and the base metal contained undesirably high concentrations of oxygen, carbon and hydrogen. A 5µm thick surface layer of the as-received

James Kennedy; Robert Schulte

1986-01-01

215

Near "real" time magnetic resonance images as a monitoring system for interstitial laser therapy: experimental protocols  

NASA Astrophysics Data System (ADS)

The failure rate of cancer treatment remains unacceptably high, still being a leading cause of mortality in adults and children despite major advances over the past 50 years in the fields of surgery, radiation therapy and, more recently, chemo and immunotherapy. Surgical access to some deep tumors of the head and neck and other areas often require extensive dissections with residual functional and cosmetic deformities. Repeated treatment is not possible after maximum dose radiotherapy and chemotherapy is still limited by its systemic toxicity. An attractive solution to these problems would be the development of a new adjunctive method combining the best features of interstitial laser therapy for selective tumor destruction via minimally invasive techniques for access and 3-D magnetic resonance imaging (MRI) as a monitoring system for laser-tissue interactions. Interstitial laser therapy (ILT) via fiberoptics allow laser energy to be delivered directly into deeper tissues. However, this concept will become clinically useful only when noninvasive, accurate, and reproducible monitoring methods are developed to measure energy delivery to tissues. MRI has numerous advantages in evaluating the irreversible effects of laser treatment in tissues, since laser energy includes changes not only in the thermal motions of hydrogen protons within the tissue, but also in the distribution and mobility of water and lipids. These techniques should greatly improve the use of ILT in combination with MRI to allow treatment of deeper, more difficult to reach tumors of head and neck and other anatomical areas with a single needle stick.

Castro, Dan J.; Farahani, Keyvan; Soudant, Jacques; Zwarun, Andrew A.; Lufkin, Robert B.

1992-06-01

216

Interstitial lung disease associated with Equine Infectious Anemia Virus infection in horses.  

PubMed

EIA (Equine Infectious Anemia) is a blood-borne disease primarily transmitted by haematophagous insects or needle punctures. Other routes of transmission have been poorly explored. We evaluated the potential of EIAV (Equine Infectious Anemia Virus) to induce pulmonary lesions in naturally infected equids. Lungs from 77 EIAV seropositive horses have been collected in Romania and France. Three types of lesions have been scored on paraffin-embedded lungs: lymphocyte infiltration, bronchiolar inflammation, and thickness of the alveolar septa. Expression of the p26 EIAV capsid (CA) protein has been evaluated by immunostaining. Compared to EIAV-negative horses, 52% of the EIAV-positive horses displayed a mild inflammation around the bronchioles, 22% had a moderate inflammation with inflammatory cells inside the wall and epithelial bronchiolar hyperplasia and 6.5% had a moderate to severe inflammation, with destruction of the bronchiolar epithelium and accumulation of smooth muscle cells within the pulmonary parenchyma. Changes in the thickness of the alveolar septa were also present. Expression of EIAV capsid has been evidenced in macrophages, endothelial as well as in alveolar and bronchiolar epithelial cells, as determined by their morphology and localization. To summarize, we found lesions of interstitial lung disease similar to that observed during other lentiviral infections such as FIV in cats, SRLV in sheep and goats or HIV in children. The presence of EIAV capsid in lung epithelial cells suggests that EIAV might be responsible for the broncho-interstitial damages observed. PMID:24289102

Bolfa, Pompei; Nolf, Marie; Cadoré, Jean-Luc; Catoi, Cornel; Archer, Fabienne; Dolmazon, Christine; Mornex, Jean-François; Leroux, Caroline

2013-01-01

217

Interstitial lung disease associated with Equine Infectious Anemia Virus infection in horses  

PubMed Central

EIA (Equine Infectious Anemia) is a blood-borne disease primarily transmitted by haematophagous insects or needle punctures. Other routes of transmission have been poorly explored. We evaluated the potential of EIAV (Equine Infectious Anemia Virus) to induce pulmonary lesions in naturally infected equids. Lungs from 77 EIAV seropositive horses have been collected in Romania and France. Three types of lesions have been scored on paraffin-embedded lungs: lymphocyte infiltration, bronchiolar inflammation, and thickness of the alveolar septa. Expression of the p26 EIAV capsid (CA) protein has been evaluated by immunostaining. Compared to EIAV-negative horses, 52% of the EIAV-positive horses displayed a mild inflammation around the bronchioles, 22% had a moderate inflammation with inflammatory cells inside the wall and epithelial bronchiolar hyperplasia and 6.5% had a moderate to severe inflammation, with destruction of the bronchiolar epithelium and accumulation of smooth muscle cells within the pulmonary parenchyma. Changes in the thickness of the alveolar septa were also present. Expression of EIAV capsid has been evidenced in macrophages, endothelial as well as in alveolar and bronchiolar epithelial cells, as determined by their morphology and localization. To summarize, we found lesions of interstitial lung disease similar to that observed during other lentiviral infections such as FIV in cats, SRLV in sheep and goats or HIV in children. The presence of EIAV capsid in lung epithelial cells suggests that EIAV might be responsible for the broncho-interstitial damages observed. PMID:24289102

2013-01-01

218

Homogeneous phase separation in binary alloys under ion irradiation conditions: Role of interstitial atoms  

SciTech Connect

Kinetic Monte Carlo simulations have been performed to investigate homogeneous precipitation in binary metal alloys under ion irradiation conditions. The kinetic model includes defect production, recombination, defect trapping, the formation of defect-solute complexes, and atomic mixing. While no special assumptions are made about vacancy diffusion, interstitial diffusion is assumed fast compared to the characteristic time scales of all other processes. The diffusion path of an interstitial, moreover, ends with one of the three possible outcomes: recombination, trapping in a solute-rich location, or clustering with other interstitials. Interstitials promote solute segregation in this model by the formation of mobile interstitial-solute complexes. Several unusual features of radiation-induced precipitation are revealed in this model. For ideal alloys, we find at a given temperature that for every trapping number [i.e., the minimum number of nearest-neighbor solute (type B) atoms required to trap a migrating interstitial, N{sub BT}], there exists a corresponding defect pair production rate K{sub 0}, below which the alloy becomes a random solution state and above which macroscopic phase separation occurs. K{sub 0} depends on the length scale of trapping sites L as L{sup 4}. Solute-rich precipitates have the composition c{sub B} approaching c{sub B}=N{sub BT}/z, where z is the lattice coordination number. This feature results in 'swelling' of precipitates, i.e., dilution of initially pure (c{sub B}=1) precipitates located in the matrix prior to ion irradiation. Ballistic mixing is observed to erode precipitates, and above some critical rate the system reverts to a random solution. For ideal solutions, and even those with a small tendency for ordering, phase separation occurs due to the interstitial interaction with solutes. At sufficiently high positive values of the heats of mixing, the usual thermal vacancy-driven precipitation prevails. Between these low and high limits, the alloy unexpectedly enters a field of solid solutions. Finally, it is shown that even in the absence of the interstitial trapping (N{sub BT}>z), alloys with a small positive ordering energy can undergo nonequilibrium phase separation at a composition below its solubility limit due to an effective trapping of vacancies in solute-rich locations. The significance of these findings for real alloy systems is discussed.

Krasnochtchekov, P.; Averback, R. S.; Bellon, P. [Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (United States)

2007-04-01

219

Three-Dimensional Sonography With Needle Tracking  

PubMed Central

Objective Image-guided prostate biopsy has become routine in medical diagnosis. Although it improves biopsy outcome, it mostly operates in 2 dimensions, therefore lacking presentation of information in the complete 3-dimensional (3D) space. Because prostatic carcinomas are nonuniformly distributed within the prostate gland, it is crucial to accurately guide the needles toward clinically important locations within the 3D volume for both diagnosis and treatment. Methods We reviewed the uses of 3D image-guided needle procedures in prostate cancer diagnosis and cancer therapy as well as their advantages, work flow, and future directions. Results Guided procedures for the prostate rely on accurate 3D target identification and needle navigation. This 3D approach has potential for better disease diagnosis and therapy. Additionally, when fusing together different imaging modalities and cancer probability maps obtained from a population of interest, physicians can potentially place biopsy needles and other interventional devices more accurately and efficiently by better targeting regions that are likely to host cancerous tissue. Conclusions With the information from anatomic, metabolic, functional, biochemical, and biomechanical statuses of different regions of the entire gland, prostate cancers will be better diagnosed and treated with improved work flow. PMID:18499849

Shen, Feimo; Shinohara, Katsuto; Kumar, Dinesh; Khemka, Animesh; Simoneau, Anne R.; Werahera, Priya N.; Li, Lu; Guo, Yujun; Narayanan, Ramkrishnan; Wei, Liyang; Al Barqawi; Crawford, E. David; Davatzikos, Christos; Suri, Jasjit S.

2012-01-01

220

Buffon Needle Problem Application to Space Exploration  

E-print Network

In this article the possibility of application of classical Buffon needle problem to the investigation of orientation engine firing problem has been investigated. Such an approach makes it possible to get a reliable EP of this undesired event without using a more complicated analysis.

A. V. Sedelnikov

2010-06-01

221

Percutaneous needle treatment of liver tumors  

E-print Network

· Percutaneous needle treatment of liver tumors · Target multiple tumors through a single incisionmm x 90mm x 260mm · Autoclavable I. Free Space III. Bovine Liver · Precurved concentric nitinol tubes.80 Bovine Liver (mm) 3.32 ± 2.66 II. Ethanol Solution Future Work · Human trials with manual unit · Fully

Webster III, Robert James

222

The Double-Needle Felling Machine. Module 17.  

ERIC Educational Resources Information Center

This module on the double-needle felling machine, one in a series dealing with industrial sewing machines, their attachments, and operation, covers two topics: performing special operations on the double-needle felling machine (straight seams) and performing special operations on the double-needle felling machine (curved flat-felled seams). For…

South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

223

Technical Communication Piezoelectric Vibrating Needle and Catheter for  

E-print Network

Technical Communication Piezoelectric Vibrating Needle and Catheter for Enhancing Ultrasound) were customized by adhering in place two piezoelectric actuators. These created 1­8 kHz vibrations when of the needle or catheter tip would be helpful. We describe a piezoelectric needle and catheter design

Smith, Stephen

224

Evaluation of Robotic Needle Steering in ex vivo Tissue.  

PubMed

Insertion velocity, tip asymmetry, and shaft diameter may influence steerable needle insertion paths in soft tissue. In this paper we examine the effects of these variables on needle paths in ex vivo goat liver, and demonstrate practical applications of robotic needle steering for ablation, biopsy, and brachytherapy. All experiments were performed using a new portable needle steering robot that steers asymmetric-tip needles under fluoroscopic imaging. For bevel-tip needles, we found that larger diameter needles resulted in less curvature, i.e. less steerability, confirming previous experiments in artificial tissue. The needles steered with radii of curvature ranging from 3:4 cm (for the most steerable pre-bent needle) to 2:97m (for the least steerable bevel needle). Pre-bend angle significantly affected needle curvature, but bevel angle did not. We hypothesize that biological tissue characteristics such as inhomogeneity and viscoelasticity significantly increase path variability. These results underscore the need for closed-loop image guidance for needle steering in biological tissues with complex internal structure. PMID:21339851

Majewicz, Ann; Wedlick, Thomas R; Reed, Kyle B; Okamura, Allison M

2010-05-01

225

Modeling and control of needles with torsional friction.  

PubMed

A flexible needle can be accurately steered by robotically controlling the bevel tip orientation as the needle is inserted into tissue. Friction between the long, flexible needle shaft and the tissue can cause a significant discrepancy between the orientation of the needle tip and the orientation of the base where the needle angle is controlled. Our experiments show that several common phantom tissues used in needle steering experiments impart substantial friction forces to the needle shaft, resulting in a lag of more than 45 ( degrees ) for a 10 cm insertion depth in some phantoms; clinical studies report torques large enough to cause similar errors during needle insertions. Such angle discrepancies will result in poor performance or failure of path planners and image-guided controllers, since the needles used in percutaneous procedures are too small for state-of-the-art imaging to accurately measure the tip angle. To compensate for the angle discrepancy, we develop an estimator using a mechanics-based model of the rotational dynamics of a needle being inserted into tissue. Compared to controllers that assume a rigid needle in a frictionless environment, our estimator-based controller improves the tip angle convergence time by nearly 50% and reduces the path deviation of the needle by 70%. PMID:19695979

Reed, Kyle B; Okamura, Allison M; Cowan, Noah J

2009-12-01

226

Modeling and Control of Needles with Torsional Friction  

PubMed Central

A flexible needle can be accurately steered by robotically controlling the bevel tip orientation as the needle is inserted into tissue. Friction between the long, flexible needle shaft and the tissue can cause a significant discrepancy between the orientation of the needle tip and the orientation of the base where the needle angle is controlled. Our experiments show that several common phantom tissues used in needle steering experiments impart substantial friction forces to the needle shaft, resulting in a lag of over 45° for a 10 cm insertion depth in some phantoms; clinical studies report torques large enough to cause similar errors during needle insertions. Such angle discrepancies will result in poor performance or failure of path planners and image-guided controllers, since the needles used in percutaneous procedures are too small for state-of-the-art imaging to accurately measure the tip angle. To compensate for the angle discrepancy, we develop an estimator using a mechanics-based model of the rotational dynamics of a needle being inserted into tissue. Compared to controllers that assume a rigid needle in a frictionless environment, our estimator-based controller improves the tip angle convergence time by nearly 50% and reduces the path deviation of the needle by 70%. PMID:19695979

Reed, Kyle B.; Okamura, Allison M.; Cowan, Noah J.

2010-01-01

227

An optical smart needle : point-of-care technologies for integrated needle guidance using optical frequency domain ranging  

E-print Network

Obtaining accurate needle placement is of critical importance in many medical scenarios. In the setting of fine needle aspiration biopsy (FNAB), manual palpation is often the only cue for determining the optimal position ...

Goldberg, Brian, 1979-

2009-01-01

228

Irradiation system for interstitial photodynamic therapy  

NASA Astrophysics Data System (ADS)

Interstitial Photodynamic Therapy (IPDT) is a promising form of treatment of deep-seated and bulky malignant tumors, based on the lethal cell response to the photochemical reactions when drug is light activated in presence of oxygen. In order to accomplish an effective internal illumination, laser sources are preferably used because of two important reasons: the monochromatic light can be confined to the narrow absorption band of the drug and the laser beam is easily focused into optical fibers. In this work the development of a diode-laser-light-source is presented. The system is tuned by temperature to get a better match in the 5-ALA absorption band. This system also comprises a trifurcated fiber system to accomplish interstitial illumination.

Pacheco, L.; Stolik, S.; De la Rosa, J.

2013-11-01

229

Autoimmune thyroiditis presenting as interstitial granulomatous dermatitis.  

PubMed

A 54-year-old female presented with recurrent, widespread, erythematous, painful plaques, over a 3-month period. Skin biopsy was compatible with interstitial granulomatous dermatitis. Additional investigation revealed hypothyroidism and positive anti-thyroid antibodies. Normalization of thyroid function and high-potency topical corticosteroids provided only transitory improvement of the dermatosis. Interstitial granulomatous dermatitis is a histologic inflammatory reaction, with variable cutaneous expression. It has been reported in association with several drugs, lymphoproliferative diseases and autoimmune disorders, such as rheumatoid arthritis, systemic lupus erythematosus and vasculitis, but association with autoimmune thyroiditis is rare. Optimal therapy for this condition is yet to be established, but topical corticosteroids have been a mainstay of treatment. In most cases, this disease is characterized by flares and remissions. PMID:23044569

Antunes, Joana; Pacheco, David; Travassos, Ana Rita; Soares-Almeida, Luís Miguel; Filipe, Paulo; Sacramento-Marques, Manuel

2012-01-01

230

Interstitial granulomatous dermatitis with plaques and arthritis.  

PubMed

Interstitial granulomatous dermatitis (IGD) is a histopathological disorder characterised by an infiltration of the reticular dermis with a predominance of interstitial and palisadic histiocytes with a few areas of degenerating collagen bundles associated with a variable number of polynuclear neutrophils and eosinophils. There are several clinical conditions with a pattern of IGD. The linear form associated with arthritis was the first variety described. There is also a second form, which presents with plaques. This variety may be associated with arthritis, use of certain drugs or the presence of different systemic disorders. We report a case of IGD with plaques and arthritis. We discuss the differential clinical and histological diagnosis with other inflammatory skin lesions, which may be associated with joint disorders and collagen degeneration. We believe that it should be considered in patients presenting with arthritis and skin lesions. PMID:12804998

Bañuls, José; Betlloch, Isabel; Botella, Rafael; Jiménez, Maria José; Blanes, Mar; Pascual, José Carlos; Belinchón, Isabel; Silvestre, Juan Francisco

2003-01-01

231

Interstitial granulomatous drug reaction to anakinra.  

PubMed

Interstitial granulomatous drug reactions are an uncommon entity presenting as asymptomatic, annular, erythematous to violaceous plaques. The incidence of such reactions has been increasing with the use of biologic agents. We report, to the best of our knowledge, the first such reaction to the interleukin (IL)-1 inhibitor anakinra. Our patient presented with pink dermal plaques and nodules in the periaxillary region which resolved with discontinuation of anakinra and recurred upon restarting anakinra. Biopsy revealed a diffuse dermal infiltrate of lymphocytes and histiocytes with interspersed neutrophils and eosinophils. Fragmentation and degeneration of collagen and elastic fibers was also present. Withdrawal of anakinra led to complete resolution of the lesions. Interstitial granulomatous drug reactions are increasing in frequency and we add anakinra to the list of causative agents. PMID:18625373

Regula, Christie G; Hennessy, Jeannie; Clarke, Loren E; Adams, David R; Ioffreda, Michael D; Graber, Emmy M; Helm, Klaus F

2008-08-01

232

Self-interstitial complexes in silicon  

NASA Astrophysics Data System (ADS)

Calculations of space geometry and electron structure of self-interstitial atoms (IAs) in Si have been made in cluster approximation by using self-consistent discrete variational X?-method (DV-X?), semiempirical MINDO/3 method and molecular dynamic method (MD). The results of DV-X?calculation show that a high state density in the band gap and various spin states are observed for interstitial complexes. As follows from the analysis of the data obtained, the methods resulting from neglecting the differential overlapping, can not be used for satisfactory description of IAs properties. MD calculations prove the existence of a new stable configuration, oriented in one of the plane equivalent to (110) and containing a pair of IAs in tetrahedral cavity. The results of theoretical analysis are compared with those available in literature on the properties of IAs in Si.

Myakenkaya, G. S.; Gutsev, G. L.; Gerasimenko, N. N.; Frolov, V. V.; Chubisov, M. A.; Corbett, J. W.

1994-06-01

233

Acupuncture sensation during ultrasound guided acupuncture needling  

PubMed Central

Background Although acupuncture sensation (also known as de qi) is a cornerstone of traditional acupuncture therapy, most research has accepted the traditional method of defining acupuncture sensation only through subjective patient reports rather than on any quantifiable physiological basis. Purpose To preliminarily investigate the frequency of key sensations experienced while needling to specific, quantifiable tissue levels (TLs) guided by ultrasound (US) imaging. Methods Five participants received needling at two acupuncture points and two control points at four TLs. US scans were used to determine when each TL was reached. Each volunteer completed 32 sets of modified Southampton Needle Sensation Questionnaires. Part one of the study tested sensations experienced at each TL and part two compared the effect of oscillation alone versus oscillation + rotation. Results In all volunteers, the frequency of pricking, sharp sensations was significantly greater in shallower TLs than deeper (p=0.007); the frequency of sensations described as deep, dull and heavy, as spreading, and as electric shocks was significantly greater in deeper TLs than shallower (p=0.002). Sensations experienced did not significantly differ between real and control points within each of three TLs (p>0.05) except TL 4 (p=0.006). The introduction of needle rotation significantly increased deep, dull, heavy sensations, but not pricking and sharp sensations; within each level, the spectrum of sensation experienced during both oscillation + rotation and oscillation alone did not significantly differ between acupuncture and control points. Conclusion The preliminary study indicates a strong connection between acupuncture sensation and both tissue depth and needle rotation. Furthermore, the new methodology has been proven feasible. A further study with an objective measurement is warranted. PMID:21642648

Park, Jongbae J.; Akazawa, Margeaux; Ahn, Jaeki; Beckman-Harned, Selena; Lin, Feng-Chang; Lee, Kwangjae; Fine, Jason; Davis, Robert T; Langevin, Helene

2014-01-01

234

Interstitials in copper-zinc alloys  

Microsoft Academic Search

In Cu-30 Zn alloys during irradiation with 2-MeV electrons from a Van de Graff generator, the electrical resistivity first decreases due to radiation-enhanced ordering and then increases due to the formation of very small interstitial clusters. The activation energy during irradiation for both processes is approximately Q\\/subirr\\/ = 0.3â eV and is interpreted as half of the migration energy of

Schule

1986-01-01

235

Interstitial devices for treating deep seated tumors  

NASA Astrophysics Data System (ADS)

Techniques using intracavitary or interstitial applicators have been proposed because extracorporeal HIFU techniques are not always suitable for deep-seated tumors. Bones or gaseous pockets may indeed be located in the intervening tissue. The objective is to bring the ultrasound source as close as possible to the target through natural routes in order to minimize the effects of attenuation and phase aberration along the ultrasound pathway. Under these circumstances, it becomes possible to use higher frequency, thus increasing the ultrasonic absorption coefficient and resulting in more efficient heating of the treatment region. In contrast to extra-corporeal applicators, the design of interstitial probes imposes additional constraints relative to size and ergonomy. The goal of this paper is to present the range of miniature interstitial applicators we developed at INSERM for various applications. The sources are rotating plane water-cooled transducers that operate at a frequency between 3 and 10 MHz depending on the desired therapeutic depth. The choice of a plane transducer rather than divergent sources permits to extend the therapeutic depth and to enhance the angular selectivity of the treatment Rotating single element flat transducer can also be replaced by cylindrical arrays for rotating electronically a reconstructed plane wave. When extended zone of coagulation are required, original therapeutic modalities combining cavitation and thermal effects are used. These methods consist in favoring in depth heating by increasing the acoustic attenuation away from the transducer with the presence of bubbles. When associated to modern imaging modalities, these minimally invasive therapeutic devices offer very promising options for cancer treatment. For examples, two versions of an image-guided esophageal applicator are designed: one uses a retractable ultrasound mini probe for the positioning of the applicator, while the other is MRI compatible and offers on line monitoring of temperature. Beyond these engineering considerations, our clinical experience demonstrates that following interstitial routes for applying HIFU is an interesting therapeutic option when targeted sites cannot be reached from outside the patient.

Lafon, Cyril; Cathignol, Dominique; Prat, Frédéric; Melodelima, David; Salomir, Rares; Theillère, Yves; Chapelon, Jean-Yves

2006-05-01

236

Interstitial defects involving boron in irradiated silicon  

Microsoft Academic Search

Silicon containing high concentrations of boron has been irradiated with 2 MeV electrons at room temperature. Initially, substitutional boron atoms are displaced into interstitial sites, but with prolonged irradiation there is a further interaction between B(i) and an intrinsic defect which is believed to be the Si(i). A similar effect is found in n0-irradiated samples. A broad absorption band is

K. Laithwaite; R. C. Newman; D. H. J. Totterdell

1975-01-01

237

Nalmefene in the treatment of interstitial cystitis.  

PubMed

Nalmefene is a new narcotic antagonist that is structurally similar to naloxone and naltrexone. The drug is a long-acting oral agent that is a pure opiate antagonist without agonist activity. Nalmefene appears to be a safe and effective compound for the treatment of interstitial cystitis. Longer-term studies and Phase III randomized trials need to be completed to substantiate these encouraging findings. PMID:8284832

Stone, N N

1994-02-01

238

Interstitial lung edema triggered by marathon running.  

PubMed

The purpose of this study was to determine whether marathon running causes lung edema, and if so, to determine its effects on runners. Posterior/anterior (PA) radiographs were taken one day before the marathon and at 19, 55, and 98min post-marathon in 26 runners. The pre and post exercise radiographs of each runner were collated, and then read simultaneously. Two physicians interpreted the images independently in a blinded fashion. The PA radiographs were viewed together at each time-point and findings suggestive for interstitial lung edema were rated as 'mild,' 'moderate,' or 'severe' based on four different radiological criteria. Forty-six percent of the runners presented radiographic findings suggestive of mild to severe interstitial lung edema. Radiographic findings persisted until 98-min post-marathon, with at least moderate degree increases found more frequently in women (55%) than men (6%) (p<0.01). In conclusion, about half of the runners developed interstitial lung edema of varying degrees post-exercise with the incidence being higher in women compared to men. PMID:24369923

Zavorsky, Gerald S; Milne, Eric N C; Lavorini, Federico; Rienzi, Joseph P; Lavin, Kaleen M; Straub, Allison M; Pistolesi, Massimo

2014-01-01

239

New hosts and differential susceptibility of five-needle pine species to Dooks needle blight (Lophophacidium dooksii)  

Microsoft Academic Search

An outbreak of Dooks needle blight (Lophophacidium dooksii) in a five-needle pine genetic archive containing nine five-needle pine species and their interspecific hybrids provided an opportunity to observe the differential susceptibility of these pine species to the disease. Survey results indicated that four of the nine species in the archive were susceptible, including new hosts western white pine (Pinus monticola)

John A. McLaughlin; Pengxin Lu; Sylvia Greifenhagen; Richard Wilson

2012-01-01

240

Needle in the haystack: purulent pericarditis from injection drug use.  

PubMed

Central needle embolization is a rare complication of intravenous drug abuse which has only been reported on a handful of occasions. Previously reported cases of needle embolization to the heart have been managed conservatively (observation alone) or by surgical intervention. We report a case of purulent pericarditis without evidence of valvular vegetations resulting from an embolized, infected needle fragment. In the present case, the needle was successfully removed from the right ventricle percutaneously. This case illustrates the unique finding of purulent pericarditis due to a persistent foreign body in the right ventricle, and the nontraditional intervention performed for needle fragment removal which resulted in full clinical recovery of the patient. PMID:21805586

Steiner, Johannes; Dhingra, Ravi; Devries, James T

2012-09-01

241

Interstitial space and collagen alterations of the developing rat diaphragm  

NASA Technical Reports Server (NTRS)

The effect of growth on the relative interstitial space [%total cross-sectional area (CSA)] and collagen content of the rat diaphragm muscle was examined at postnatal ages of 0, 7, 14, and 21 days as well as in adult males. The proportion of interstitial space relative to total muscle CSA was determined by computerized image analysis of lectin-stained cross sections of diaphragm muscle. To assess collagen content and extent of collagen maturation (i.e., cross-linking), high-pressure liquid chromatography analysis was used to measure hydroxyproline concentration and the nonreducible collagen cross-link hydroxylysylpyridinoline (HP), respectively. At birth, interstitial space accounted for approximately 47% of total diaphragm muscle CSA. During postnatal growth, the relative contribution of interstitial space decreased such that by adulthood the interstitial space accounted for approximately 18% of total muscle CSA. The change in relative interstitial space occurred without a concomitant change in hydroxyproline concentration. However, the concentration of HP markedly increased with age such that the adult diaphragm contained approximately 17 times more HP than at birth. These results indicate that during development the relative CSA occupied by interstitial space decreases as muscle fiber size increases. However, the reduction in relative interstitial space is not associated with a change in collagen concentration. Thus collagen density in the interstitial space may increase with age. It is possible that the observed changes in relative interstitial space and collagen influence the passive length-force properties of the diaphragm.

Gosselin, L. E.; Martinez, D. A.; Vailas, A. C.; Sieck, G. C.

1993-01-01

242

The research of knitting needle status monitoring setup  

NASA Astrophysics Data System (ADS)

In textile production, quality control and testing is the key to ensure the process and improve the efficiency. Defect of the knitting needles is the main factor affecting the quality of the appearance of textiles. Defect detection method based on machine vision and image processing technology is universal. This approach does not effectively identify the defect generated by damaged knitting needles and raise the alarm. We developed a knitting needle status monitoring setup using optical imaging, photoelectric detection and weak signal processing technology to achieve real-time monitoring of weaving needles' position. Depending on the shape of the knitting needle, we designed a kind of Glass Optical Fiber (GOF) light guides with a rectangular port used for transmission of the signal light. To be able to capture the signal of knitting needles accurately, we adopt a optical 4F system which has better imaging quality and simple structure and there is a rectangle image on the focal plane after the system. When a knitting needle passes through position of the rectangle image, the reflected light from needle surface will back to the GOF light guides along the same optical system. According to the intensity of signals, the computer control unit distinguish that the knitting needle is broken or curving. The experimental results show that this system can accurately detect the broken needles and the curving needles on the knitting machine in operating condition.

Liu, Lu; Liao, Xiao-qing; Zhu, Yong-kang; Yang, Wei; Zhang, Pei; Zhao, Yong-kai; Huang, Hui-jie

2013-09-01

243

Dust-induced interstitial lung disease in the tropics.  

PubMed

Inhalation of dusts is an important cause of interstitial lung disease in the tropical countries such as India. While dusts of organic origin, such as the cotton dust causing byssinosis, generally cause bronchial or bronchiolar involvement and hypersensitivity pneumonitis, inorganic metallic dusts cause progressive pulmonary fibrosis. Silicosis, coal workers' pneumoconiosis, and asbestosis are the three most commonly recognized forms of pneumoconiotic pulmonary fibrosis. Pulmonary tuberculosis is an important complication seen in up to 50% of patients of silicosis in some reports from India. The presentation is generally chronic, although acute and accelerated forms of silicosis are known when the exposures are heavy. Breathlessness, dry cough, and general constitutional symptoms are commonly seen. Patients with silicotuberculosis or other forms of infection may also have significant expectoration, hemoptysis, fever, and rapid progression. Respiratory failure and chronic cor pulmonale occur in the later stages. The diagnosis is easily established if the occupational history is available. Dense nodular opacities on chest roentgenograms, which may be large in patients with massive pulmonary fibrosis, are characteristic. Emphysematous changes generally appear in advanced stages or in patients who smoke. Bronchoalveolar lavage and/or lung biopsy may occasionally be required to establish or exclude other causes of interstitial lung disease. Treatment is largely palliative, although a variety of drugs including corticosteroids and procedures such as whole lung lavage have been tried. None of these methods has yet been found successful in the treatment. Preventive safety steps, including removal of the patient from the site of exposure, are the only effective strategies to control disease progression. PMID:11584175

Jindal, S K; Aggarwal, A N; Gupta, D

2001-09-01

244

Needle Insertion with Duty-Cycled Rotation into Multiple Media  

PubMed Central

Thin, flexible needles can be steered along nonlinear paths to reach deep anatomical structures within the human body. This study builds upon previous work involving steering of bevel-tipped needles by inserting while rotating in a duty-cycled fashion. Here we investigate how needle material and radius, duty cycle, and tissue stiffness affect needle curvature. Needles were inserted into media while rotated at a specified duty cycle and the curvature was measured. A linear relationship between duty cycle and curvature was observed across all needle materials and radii, and tissue stiffnesses. Following these observations, we developed a model that encapsulates needle and tissue parameters in order to predict the duty cycle needed to achieve a desired curvature. PMID:23366042

Lehocky, Craig A.; Riviere, Cameron N.

2012-01-01

245

An Exploration of the Needling Depth in Acupuncture: The Safe Needling Depth and the Needling Depth of Clinical Efficacy  

PubMed Central

Objective. To explore the existing scientific information regarding safe needling depth of acupuncture points and the needling depth of clinical efficacy. Methods. We searched the PubMed, EMBASE, Cochrane, Allied and Complementary Medicine (AMED), The National Center for Complementary and Alternative Medicine (NCCAM), and China National Knowledge Infrastructure (CNKI) databases to identify relevant monographs and related references from 1991 to 2013. Chinese journals and theses/dissertations were hand searched. Results. 47 studies were recruited and divided into 6 groups by measuring tools, that is, MRI, in vivo evaluation, CT, ultrasound, dissected specimen of cadavers, and another group with clinical efficacy. Each research was analyzed for study design, definition of safe depth, and factors that would affect the measured depths. Depths of clinical efficacy were discussed from the perspective of de-qi and other clinical observations. Conclusions. Great inconsistency in depth of each point measured from different subject groups and tools exists. The definition of safe depth should be established through standardization. There is also lack of researches to compare the clinical efficacy. A well-designed clinical trial selecting proper measuring tools to decide the actual and advisable needling depth for each point, to avoid adverse effects or complications and promote optimal clinical efficacy, is a top priority. PMID:23935678

Lin, Jaung-Geng; Chou, Pei-Chi; Chu, Heng-Yi

2013-01-01

246

Basic technique in endoscopic ultrasound-guided fine needle aspiration for solid lesions: What needle is the best?  

PubMed Central

Basic technique for endoscopic ultrasound (EUS) of solid lesions has developed during 30 years of EUS, as endoscopes and accessory equipment, particularly needles, have been developed. Systematic high-quality examinations require understanding and planning. Needles used for EUS-guided fine needle aspiration (FNA) have gone through many improvements; some 18 characteristics of any needle are presented and these come under consideration whenever choosing the best needle for each procedure. The bright future of EUS and FNA for solid lesions currently still leaves much room for continued developments. PMID:24949410

Lachter, Jesse

2014-01-01

247

Mutual reaction between interstitial clusters in bcc Fe  

NASA Astrophysics Data System (ADS)

Clusters of self-interstitial atoms (SIAs) are commonly observed in microstructure of irradiated metals. These clusters can be formed directly in high-energy displacement cascades or as a result of interaction between individual SIAs. The majority of these clusters has features of glissile dislocation loops and perform fast thermally-activated one-dimensional glide. In this paper we present results of systematic molecular dynamics study of reactions where glissile clusters are involved. On the example of bcc iron we demonstrate that the reactions can result in a number of specific microstructural objects with different properties which may affect the microstructure evolution of irradiated metals. Particularly the reactions between the most common glissile clusters of (111) crowdions can result in coarsening, formation of immobile complexes and change of the crowdion orientation to (100) -type direction. However, particular mechanism responsible for that was found to be different from the one reported in the similar computer simulation studies. Properties of the products of mutual reactions between clusters are quite different which can influence the total microstructure evolution under irradiation. The results are obtained with the most promising interatomic potential for iron.

Terentyev, Dmitry; Malerba, Lorenzo

2007-04-01

248

Susuks: charm needles in facial soft tissues.  

PubMed

Susuks or charm needles are a form of talisman inserted and worn subcutaneously, in the face and other parts of the body, in the belief that they will enhance or preserve the wearer's beauty, youth, charisma, strength or health, or bring success in business. This mystic practice is found among some south-east Asian people, especially Malayan and Muslim females. Most susuk wearers are secretive about their hidden talismans, but these gold or silver needles are being discovered with increasing frequency now that radiographs are used more widely. An understanding of this practice and an awareness of its existence is important to avoid misdiagnosis and mismanagement of these patients. The practice of susuk wearing and its relevance to dentistry is discussed. Nine cases of facial susuk wearers are presented and previous reports are reviewed. PMID:2036281

Shanmuhasuntharam, P; Ghani, S H

1991-04-20

249

Select appropriate gavage needle for the size of the animal (see Table). Gavage needles can be reusable and made of stainless steel or single use and made of  

E-print Network

be reusable and made of stainless steel or single use and made of plastic material. Stainless steel needles are often easier to pass but plastic needles are less likely to cause injury. Stainless steel needles can

Scott, Robert A.

250

WEST NEEDLE WILDERNESS STUDY AREA, COLORADO.  

USGS Publications Warehouse

The West Needle Wilderness Study Area, southwestern Colorado, was evaluated for mineral-resource potential. An area extending westward into the wilderness near the Elk Park mine, has a probable mineral-resource potential for uranium. Uranium resources, and associated silver, nickel, cobalt, and copper, are located at the Elk Park mine, directly adjacent to the eastern study area boundary. No potential for other mineral or energy resources was identified in this study.

Van Loenen, Richard E.; Scott, David C.

1984-01-01

251

[A case of acupuncture needle dermatitis].  

PubMed

A 65-year-old female visited our clinic with painful red vesicular dermatitis of the forehead and around the left eye. She had received acupuncture for headache and shoulder stiffness 6 days before visiting our clinic. A patch test with nickel sulfate gave positive results. We treated her with the greater occipital nerve block and trigger point injection which relieved her pain. We reached the diagnosis of greater occipital trigeminal syndrome with contact dermatitis from the acupuncture needle. PMID:10998883

Morimoto, M; Kawata, K; Tsuchiya, N; Murakami, H; Kura, M; Koga, Y

2000-08-01

252

One-dimensional atomic transport by clusters of self-interstitial atoms in iron and copper  

NASA Astrophysics Data System (ADS)

Atomic-scale computer simulation has been used to study the thermally activated atomic transport of self-interstitial atoms (SIAs) in the form of planar clusters in pure Cu and f-Fe. There is strong evidence that such clusters are commonly formed in metals during irradiation with high-energy particles and play an important role in accumulation and spatial distribution of surviving defects. An extensive study of the mobility of SIA clusters containing two to 331 interstitials has been carried out using the molecular dynamics simulation technique for the temperature range from 180 to 1200 K. The results obtained show that clusters larger than three to four SIAs are one-dimensionally mobile in both Cu and Fe. Large clusters of more than 100 SIAs in Cu and 300 SIAs in Fe have significantly reduced mobility. The problem of describing one-dimensional (1D) motion in three-dimensional space is discussed. An attempt is made to describe the mobility of SIA clusters within the approximation of 1D diffusion. For clusters in both metals the effective migration energy of 1D diffusion as estimated via the jump frequency of the cluster centre of mass is found to be independent of the number of SIAs in the clusters, although the cluster jump frequency decreases with increasing cluster size. Mechanisms of 1D mobility of interstitial clusters are discussed.

Osetsky, Yu. N.; Bacon, D. J.; Serra, A.; Singh, B. N.; Golubov, S. I.

2003-01-01

253

First-principles study of diffusion of interstitial and vacancy in ? U-Zr  

NASA Astrophysics Data System (ADS)

Metallic uranium-zirconium alloys are of interest for a variety of fast reactor designs, and there is substantial experience with the behavior of metallic fuels. Yet, there remain a number of questions regarding the mechanisms controlling fission-gas-driven swelling in these alloys. Here we present results of ab initio calculations of the diffusion behavior of interstitial and vacancy point defects in ? U-Zr alloys. The formation energy and migration barrier of vacancy and interstitial defects, and the influence of Zr on these values, is obtained and compared with experimental results. Our results confirm that self-diffusion in pure ? U is via a simple vacancy mechanism, and shows anisotropic character. The calculated values of activation energy are consistent with the experimental results in the literature. For interstitial diffusion, the kick-out mechanism was found to have the smallest energy barrier. The calculations of point defects, and later Xe, in U-Zr alloys will provide a foundation for computational modeling of fission gas bubble nucleation and growth.

Huang, Gui-Yang; Wirth, Brian D.

2011-05-01

254

Exploration of new electroacupuncture needle material.  

PubMed

Background. Electro Acupuncture (EA) uses the acupuncture needle as an electrode to apply low-frequency stimulation. For its safe operation, it is essential to prevent any corrosion of the acupuncture needle. Objective. The aim of this study is to find an available material and determine the possibility of producing a standard EA needle that is biocompatible. Methods. Biocompatibility was tested by an MTT assay and cytotoxicity testing. Corrosion was observed with a scanning electron microscope (SEM) after 0.5?mA, 60?min stimulation. The straightness was measured using a gap length of 100?mm, and tensile testing was performed by imposing a maximum tensile load. Results. Phosphor bronze, Ni coated SS304, were deemed inappropriate materials because of mild-to-moderate cytotoxicity and corrosion. Ti-6Al-4V and SS316 showed no cytotoxicity or corrosion. Ti-6Al-4V has a 70 times higher cost and 2.5 times lower conductivity than SS316. The results of both straightness and tensile testing confirmed that SS316 can be manufactured as a standard product. Conclusion. As a result, we confirmed that SS316 can be used a new EA electrode material. We hope that a further study of the maximum capacity of low-frequency stimulation using an SS316 for safe operation. PMID:22675386

Lee, Sanghun; Choi, Gwang-Ho; Lee, Chang Hoon; Kim, Yu Kyoung; Lee, Saebhom; Cho, Sungjin; Yeon, Sunhee; Choi, Sun-Mi; Ryu, Yeon-Hee

2012-01-01

255

Risks of Transthoracic Needle Biopsy: How High?  

PubMed

Transthoracic needle lung biopsy is a commonly performed diagnostic procedure for pulmonary nodules and masses. To make an informed decision about whether to pursue this procedure, doctors and patients must be aware of the possible risks of the procedure. We performed a MEDLINE search, 2003-2012 to identify relevant English-language studies that included at least 100 subjects and reported data on complications of transthoracic needle lung biopsy performed within the last 10 years. We found the most common complication to be any pneumothorax (risk 15-25%), with pneumothorax requiring chest tube occurring less often (risk 4-6%). Hemorrhage, defined as radiographically visualized blood along the needle tract was common, but clinically significant hemorrhage was infrequent (~1%). Rare complications, including air embolism and tumor seeding of the biopsy tract, occurred in fewer than 1% of cases but were potentially serious. We summarize data on factors associated with complications, including patient age, COPD, lesion size and location, and number of punctures. We also provide data on techniques to mitigate severity of pneumothorax post-biopsy, such as rapid patient rollover, manual aspiration, and instillation of substances into the biopsy tract. PMID:23525679

Wiener, Renda Soylemez; Wiener, Daniel C; Gould, Michael K

2013-01-01

256

Risks of Transthoracic Needle Biopsy: How High?  

PubMed Central

Transthoracic needle lung biopsy is a commonly performed diagnostic procedure for pulmonary nodules and masses. To make an informed decision about whether to pursue this procedure, doctors and patients must be aware of the possible risks of the procedure. We performed a MEDLINE search, 2003–2012 to identify relevant English-language studies that included at least 100 subjects and reported data on complications of transthoracic needle lung biopsy performed within the last 10 years. We found the most common complication to be any pneumothorax (risk 15–25%), with pneumothorax requiring chest tube occurring less often (risk 4-6%). Hemorrhage, defined as radiographically visualized blood along the needle tract was common, but clinically significant hemorrhage was infrequent (~1%). Rare complications, including air embolism and tumor seeding of the biopsy tract, occurred in fewer than 1% of cases but were potentially serious. We summarize data on factors associated with complications, including patient age, COPD, lesion size and location, and number of punctures. We also provide data on techniques to mitigate severity of pneumothorax post-biopsy, such as rapid patient rollover, manual aspiration, and instillation of substances into the biopsy tract. PMID:23525679

Wiener, Renda Soylemez; Wiener, Daniel C.; Gould, Michael K.

2013-01-01

257

Interstitial gas effect on vibrated granular columns  

NASA Astrophysics Data System (ADS)

Vibrated granular materials have been intensively used to investigate particle segregation, convection, and heaping. We report on the behavior of a column of heavy grains bouncing on an oscillating solid surface. Measurements indicate that, for weak effects of the interstitial gas, the temporal variations of the pressure at the base of the column are satisfactorily described by considering that the column, despite the observed dilation, behaves like a porous solid. In addition, direct observation of the column dynamics shows that the grains of the upper and lower surfaces are in free fall in the gravitational field and that the dilation is due to a small delay between their takeoff times.

Pastenes, Javier C.; Géminard, Jean-Christophe; Melo, Francisco

2014-06-01

258

Interstitial gas effect on vibrated granular columns.  

PubMed

Vibrated granular materials have been intensively used to investigate particle segregation, convection, and heaping. We report on the behavior of a column of heavy grains bouncing on an oscillating solid surface. Measurements indicate that, for weak effects of the interstitial gas, the temporal variations of the pressure at the base of the column are satisfactorily described by considering that the column, despite the observed dilation, behaves like a porous solid. In addition, direct observation of the column dynamics shows that the grains of the upper and lower surfaces are in free fall in the gravitational field and that the dilation is due to a small delay between their takeoff times. PMID:25019768

Pastenes, Javier C; Géminard, Jean-Christophe; Melo, Francisco

2014-06-01

259

Diagnosis and management of interstitial cystitis.  

PubMed

Interstitial cystitis is a diagnosis of exclusion. The definition has expanded over the years to encompass painful bladder syndrome. It is disease state that is often delayed in its diagnosis and difficult to manage. Treatment options include oral and intravesical therapies as well as both minor and major surgical options. Also, a patient can improve symptoms by following self-management recommendations that focus on both diet and stress management. Treatment options should be periodically evaluated with validated questionnaires to insure they are improving the patient's symptoms, and a multidisciplinary approach is best to manage the patient. PMID:25155121

Barr, Susan

2014-09-01

260

Interstitial cystitis: epidemiology, pathophysiology, and clinical presentation.  

PubMed

Interstitial cystitis, or painful bladder syndrome, can present with lower abdominal pain/discomfort and dyspareunia, and pain in any distribution of lower spinal nerves. Patients with this condition experience some additional symptoms referable to the bladder, such as frequency, urgency, or nocturia. It can occur across all age groups, although the specific additional symptoms can vary in prevalence depending on patient age. It should be considered in patients who have other chronic pain conditions such as fibromyalgia, chronic fatigue, irritable bowel, and vulvodynia. The cause is still largely not understood, although there are several postulated mechanisms. PMID:25155120

McLennan, Mary T

2014-09-01

261

Procedures for interstitial radioactive gold grains  

SciTech Connect

Detailed implantation procedures and safety guidelines for use of interstitial radioactive gold grains are presented. These guidelines have been found to be of practical value for personnel involved with the implant to ensure compliance with regulations but are not necessarily the only procedures which could be utilized. Topics covered include: Description of Grains and Implantation, Management and Planning of Au-198, Source Logging, Source Transportation, Source Accounting During and After Implant, Room Monitoring, Recording, Dosimetry Films, Nursing Procedures, Levels in Patients Containing Radioactivity, and Patient Discharge of Radioactive Patients.

Sharma, S.C. (Univ. of Louisville, KY (USA))

1989-01-01

262

Penicilliosis marneffei complicated with interstitial pneumonia.  

PubMed

A 71-year-old man with interstitial pneumonia was hospitalized due to a pulmonary infection. He had been living in Thailand and had returned to Japan three months earlier. Antibiotic therapy initially cleared the infection; however, the patient's condition relapsed. Pseudomonas aeruginosa and Penicillium sp. were both detected in sputum and bronchial lavage fluid cultures and Penicillium sp. was identified to be P. marneffei. The infiltration observed on chest radiographs improved following treatment with itraconazole and tazobactam/piperacillin, and no relapse occurred. We herein report the first case of a non-HIV patient with P. marneffei infection in Japan. PMID:24531088

Furusawa, Haruhiko; Miyazaki, Yasunari; Sonoda, Shiro; Tsuchiya, Kimitake; Yaguchi, Takashi; Kamei, Katsuhiko; Inase, Naohiko

2014-01-01

263

Biomedical engineering meets acupuncture - development of a miniaturized 48-channel skin impedance measurement system for needle and laser acupuncture  

PubMed Central

Background Due to controversially discussed results in scientific literature concerning changes of electrical skin impedance before and during acupuncture a new measurement system has been developed. Methods The prototype measures and analyzes the electrical skin impedance computer-based and simultaneously in 48 channels within a 2.5×3.5 cm matrix. Preliminary measurements in one person were performed using metal needle and violet laser (405 nm) acupuncture at the acupoint Kongzui (LU6). The new system is an improvement on devices previously developed by other researchers for this purpose. Results Skin impedance in the immediate surroundings of the acupoint was lowered reproducibly following needle stimulation and also violet laser stimulation. Conclusions A new instrumentation for skin impedance measurements is presented. The following hypotheses suggested by our results will have to be tested in further studies: Needle acupuncture causes significant, specific local changes of electrical skin impedance parameters. Optical stimulation (violet laser) at an acupoint causes direct electrical biosignal changes. PMID:21092296

2010-01-01

264

Interstitial therapy of perineal and gynecological malignancies  

SciTech Connect

Thirty-five patients, 38 to 88 years of age, were treated with 125-Iodine or 192-Iridium interstitial implants at Stanford University Medical Center between July 1974, and December, 1978. There were 25 primary epithelial malignancies, eight extensions from intrapelvic organs and two metastatic tumors (hypernephroma and Hodgkin's disease). The involved sites were: urethra (6 patients); vulva (9 patients); vagina (8 patients); anus (7 patients); cervix (5 patients). Implantation was usually performed to treat evident or microscopic disease in conjunction with external beam pelvic treatment with or without local excision. Computerized implant preplanning was used.125-Iodine seeds were inserted either directly or within absorbable suture Polyglactin 910; 192-Iridium in nylon carriers was placed by suture or transperineal template. Two patients were lost to follow-up leaving 33 patients, 27 of whom are alive and free of local disease from 37 to 76 months. The overall local control rate was 88%, or 29/33 patients. All four local recurrences appeared before 24 months. Minor complications included: 10 patients with transient mucositis, four with superficial ulcers, and one patient with infection at the implanted site. Two major complications occurred: a necrotic rectal ulcer requiring a colostomy and a contracted, painful bladder necessitating a urinary diversion. It is concluded that in selected cases interstitial irradiation provides good local control of perineal and gynecological malignancies with low morbidity in this elderly and quite often fragile group of patients.

Martinez, A.; Herstein, P.; Portnuff, J.

1983-03-01

265

Interstitial collagenase gene expression in colonic neoplasia.  

PubMed Central

Tumor invasion and metastasis are complex phenomena believed to be facilitated by the disruption of collagen and elastin fibers in the extracellular matrix. Interstitial collagenase gene expression was studied in colonic adenocarcinoma and adenoma using in situ hybridization. The data indicated that three cell types within the tumor stroma expressed collagenase transcripts; they were eosinophils, fibroblasts, and vascular endothelium. In all 12 adenocarcinomas, a high to moderate level of expression was seen in 1 to 5% of eosinophils and in occasional fibroblasts, whereas these cell types in non-neoplastic mucosa adjacent to tumor showed no detectable expression. Two adenocarcinomas showed expression in hyperplastic endothelium in vascularized granulation tissue. Two out of three adenomas showed expression in eosinophils and fibroblasts at a reduced level. Tissue inhibitor of metalloproteinase-1 gene expression was, however, negligible in all tissue examined. These results suggest that interstitial collagenase gene activation in the tumor stroma, especially eosinophils, may have an important role in tumor invasion and metastasis. Images Figure 1 Figure 2 Figure 3 PMID:8362969

Gray, S. T.; Yun, K.; Motoori, T.; Kuys, Y. M.

1993-01-01

266

Integrated system for interstitial photodynamic therapy  

NASA Astrophysics Data System (ADS)

To develop PDT beyond treatment of thin superficial tumors, to also be an efficient treatment alternative to deeply located and/or thick tumors, a system based on interstitial illumination using multiple fibers has been developed. Conditions that could benefit from such a treatment modality are for instance malignant brain tumors and tumors in the oral cavity. In interstitial PDT one needs to use multiple fibers for light delivery in order to allow treatments of tumors larger than a few millimeters in diameter. Our sytem consists of a laser light source, a beam-splitting system dividing the light into three or six output fibers and a custom-made dosimetry program. The concept is then to use these fibers not only for delivering the treatment light, but also to measure parameters of interest for the treatment outcome. The fluence rate of the light emitted by each fiber is measured at the positions of the other fiber tips. From these results the light dose at all positions could be recalculated. Changes in optical properties as well as bleaching and concentration of the photosensitizer during the treatment could be monitored and compensated for in the dosimetry. Tumors have been treated both in experimental studies and in patients with thick superficial Basal Cell Carcinomas. Almost all treated skin lesions responded with complete response.

Andersson-Engels, Stefan; Bendsoe, Niels; Johansson, Thomas; Palsson, Sara; Thompson, Marcelo S.; Stenram, Unne; Svanberg, Katarina; Svanberg, Sune

2003-08-01

267

Multigenerational interstitial growth of biological tissues  

PubMed Central

This study formulates a theory for multigenerational interstitial growth of biological tissues whereby each generation has a distinct reference configuration determined at the time of its deposition. In this model, the solid matrix of a growing tissue consists of a multiplicity of intermingled porous permeable bodies, each of which represents a generation, all of which are constrained to move together in the current configuration. Each generation’s reference configuration has a one-to-one mapping with the master reference configuration, which is typically that of the first generation. This mapping is postulated based on a constitutive assumption with regard to that generations’ state of stress at the time of its deposition. For example, the newly deposited generation may be assumed to be in a stress-free state, even though the underlying tissue is in a loaded configuration. The mass content of each generation may vary over time as a result of growth or degradation, thereby altering the material properties of the tissue. A finite element implementation of this framework is used to provide several illustrative examples, including interstitial growth by cell division followed by matrix turnover. PMID:20238138

Ricken, Tim

2010-01-01

268

Interstitial lung disease in systemic sclerosis.  

PubMed

Based on international collaborative data, interstitial lung disease is now the most frequent cause of death in systemic sclerosis (SSc), having supplanted renal crisis in that regard. Despite detailed explorations of candidate mediators, no primary pathway in the pathogenesis of interstitial lung disease associated with SSc (SSc-ILD) has been definitively identified and, therefore, treatment with current agents is only partially successful. However, as immunomodulatory agents do, on average, retard progression of lung disease, early identification of SSc-ILD, using thoracic high resolution computed tomography (HRCT), is highly desirable. The decision whether to introduce therapy immediately is often difficult as the balance of risk and benefit favours a strategy of careful observation when lung disease is very limited, especially in long-standing SSc. The threshold for initiating treatment is substantially reduced when lung disease is severe, systemic disease is short in duration or ongoing progression is evident, based on pulmonary function tests and symptoms. This review summarises epidemiology, pathogenesis, difficult clinical problems and management issues in SSc-ILD. PMID:25217474

Wells, Athol U

2014-10-01

269

Respiratory bronchiolitis-interstitial lung disease  

PubMed Central

Respiratory bronchiolitis-associated interstitial lung disease (RB-ILD) is a rare, mild inflammatory pulmonary disorder that occurs almost exclusively in current or former heavy smokers, usually between the third and sixth decades, most likely with no gender predilection. The onset is usually insidious with exertional dyspnea and persistent cough, which may be non-productive, developing over a course of weeks or months. RB-ILD may also be diagnosed in asymptomatic patients with functional impairment and chest radiograph or high-resolution computed tomography (HRCT) abnormalities. Histologically, RB-ILD is characterized by the accumulation of yellow-brown pigmented macrophages within the lumens of respiratory bronchioles and alveolar ducts, associated with a patchy submucosal and peribronchiolar chronic inflammation. Common findings also include mild bronchiolar and peribronchiolar alveolar fibrosis that expands contiguous alveolar septa and leads to architectural distortion as well as centrilobular emphysema. Chest radiographs in patients with RB-ILD typically show fine reticulonodular interstitial opacities, while on HRCT central and peripheral bronchial wall thickening, centrilobular nodules, and ground-glass opacities associated with upper lobe centrilobular emphysema are most frequently reported. Pulmonary function testing may be normal but usually demonstrates mixed, predominantly obstructive abnormalities, often combined with hyperinflation and usually associated with a mild to moderate reduction in carbon monoxide diffusion capacity (DLco). The course of RB-ILD is heterogeneous. Some patients respond favorably to corticosteroids and/or smoking cessation, but often there is no functional improvement and the disease progresses despite smoking cessation and treatment. PMID:25011486

2014-01-01

270

Fire performance of interstitial space construction system  

NASA Astrophysics Data System (ADS)

Two unique walk-on deck construction systems were exposed to the standard NFPA 251 time-temperature fire exposure in order to evaluate their fire performance. A large scale steel structure was used in the test program to simulate construction systems found in the field. The structure consisted of two large functional floors separate by an interstitial space in which a walk-on deck system was constructed from light-weight concrete, and the second was built with poured gypsum. Three complete two hour fire tests were conducted along with one shorter test. Critical areas evaluated were the top functional floor, unprotected steel work in the interstitial space, response of the walk-on deck systems, and protection for a heavy steel column located in the center of each test bay. Test data were compared with the fire endurance test requirements of NFPA 251. Computer predictions were also made using the FIRES-08 model to determine its ability to accurately predict the construction systems performance.

Lawson, J. R.

1985-05-01

271

Needle-shape quality control by shadowgraphic image processing  

NASA Astrophysics Data System (ADS)

We propose a needle-shape quality-control method. To this end, we have devised a new acquisition system that combines a camera and a backlight. Needle measurements are carried out at a micrometric scale using shadowgraphic image processing. Our method not only distinguishes good needles from bad ones, but also allows classifying flawed needles into various categories of defects. This classification is important because some categories of defects can affect the entire production, whereas others do not. The results of our needle-shape quality-control method are validated using real samples directly off the manufacturing line. Needles are correctly classified at >97%, and accurate measurements on global shape characteristics such as straightness and sharpness are obtained.

Mairesse, Fabrice; Sliwa, Tadeusz M.; Roy, Michaël; Voisin, Yvon

2011-02-01

272

Psychosocial predictors of needle sharing among intravenous drug users.  

PubMed

This study examined the relationship between health beliefs and needle sharing in a sample of 226 heroin detoxification clients. Zero-order correlations revealed that needle sharing was positively associated with perceived susceptibility and AIDS anxiety, and negatively associated with self-efficacy and communication skill in negotiating safe needle practices. Logistic regression analysis showed that demographic and situational factors also play a role in needle sharing. White race and injection of drugs in shooting galleries or other public places increase the odds of sharing a "dirty" needle, while that probability decreases sharply as a function of drug users' self-efficacy. This last finding suggests that preventive clinical interventions such as counseling or psychoeducational groups maybe needed to help drug users develop confidence in resisting needle sharing. PMID:8407025

Gibson, D R; Choi, K H; Catania, J A; Sorensen, J L; Kegeles, S

1993-08-01

273

Fabrication of Metallic Microneedle by Electroplating and Sharpening of it by Electrochemical Etching  

NASA Astrophysics Data System (ADS)

Aiming at the use in low-invasive medical treatments, this paper reports a fabrication of metallic microneedle, which has a three-dimensionally sharp tip. Compared to a silicon or polymer needle which we previously proposed, a metallic needle has toughness to evade breakage. Even if it is broken, it does not become small pieces thanks to its ductility, which increases the safety for a human body. A nickel needle was fabricated using electroplating, followed by sharpening it by electrochemical etching. A smooth tip surface is obtained due to electrochemical etching reactions. Sharpness and smoothness of the tip are effective for easy insertion in the viewpoint of large stress concentration and small friction, respectively. An experiment of inserting the fabricated needle into an artificial skin of silicone rubber was carried out. The resistance force during insertion was much reduced compared to that of commercial stainless needle (23 G: shank diameter 650 µm). Although a fabricated metallic needle was inserted and pulled-out for several times, it was not broken in any trial. By changing the angle between object surface and needle axis, the insertion experiments were carried out. Fabricated nickel needle was not broken for any angle, while silicon needle was broken in case the angle is small, i.e., the needle is much inclined from normal direction of the surface, which ensures the safety of metallic microneedle to human body in the viewpoint of breakage.

Huang, Chih-Hao; Tanaka, Takahiro; Takaoki, Yutaka; Izumi, Hayato; Takahashi, Tomokazu; Suzuki, Masato; Aoyagi, Seiji

274

Wavelength shifts in fluorescence maxima of stressed and non-stressed Norway spruce needles over the growing season  

NASA Technical Reports Server (NTRS)

Laboratory fluorescence measurements of first and third year metal stressed and non stressed Norway spruce needles collected in May, Jul. Sep. and Nov. display significant wavelength shifts in the intensity maxima in the blue, green, red, and near infrared spectral regions, with the largest shifts occurring in the blue spectral region for both first and third year needles from Nov. Smaller, but the otherwise significant shifts also take place in the blue spectral region for first year needles from Sep. in the red spectral region for third year neddles from May, Jul. and Sep. and in the near infrared spectral region for first and third year needles from Jul. and Sep. Wavelength shifts in needle fluorescence maxima over the growing season are greatest in the blue and to a lesser extent, greenspectral regions from Sep. to Nov. but are also significant in the red and near infrared spectral regions from Jul. to Sep. and Sep. to Nov., and in the near infrared spectral region also from May to Jul.

Banninger, Cliff; Chappelle, E.

1991-01-01

275

An improved needle steering model with online parameter estimator  

Microsoft Academic Search

Purpose: Needle steering can improve targeting accuracy and guide the tip to areas that are currently not accessible. This paper proposes and validates a steering model to be capable of predicting the system dynamics during needle-tissue contact procedure.\\u000a Methods: The spring-beam-damper needle steering model we proposed has been extended with depth-varying mean parameters considering the tissue inhomogeneity. Local polynomial approximations

Kai Guo Yan; Tarun Podder; Di Xiao; Yan Yu; Tien-I Liu; CWS Cheng; Wan Sing Ng

2006-01-01

276

Path Planning for Flexible Needles Using Second Order Error Propagation  

Microsoft Academic Search

In this paper we propose a computationally efficient method for the steering of flexible needles with a bevel tip in the presence\\u000a of uncertainties for the case when there are no obstacles in the environment. Based on the stochastic model for the needles,\\u000a we develop a new framework for path planning of a flexible needle with a bevel tip. This

Yunfeng Wang; Gregory S. Chirikjian

2008-01-01

277

Task force on chronic interstitial lung disease in immunocompetent children  

Microsoft Academic Search

Task force on chronic interstitial lung disease in immunocompetent children. A. Clement, and committee members. #ERS Journals Ltd 2004. ABSTRACT: Chronic interstitial lung diseases in children represent a heterogeneous group of disorders of both known and unknown causes that share common histological features. Despite many efforts these diseases continue to present clinical management dilemmas, principally because of their rare frequency

A. Clement; J. Allen; B. Corrin; R. Dinwiddie; H. Ducou; E. Eber; G. Laurent; R. Marshall; F. Midulla; A. G. Nicholson

278

Free-floating collagen fibers in interstitial mycosis fungoides.  

PubMed

We present a case of interstitial mycosis fungoides showing pseudodovascular clefts with "free-floating" collagen fibers surrounded by neoplastic T lymphocytes. Such a finding further expands the histopathologic spectrum of mycosis fungoides and could be taken into account in its differential diagnosis from granuloma annulare, inflammatory morphea, and interstitial granulomatous drug reaction. PMID:20145533

Ferrara, Gerardo; Crisman, Giuliana; Zalaudek, Iris; Argenziano, Giuseppe; Stefanato, Catherine M

2010-06-01

279

Interstitial Solutes and Deformation in Nb and Nb Single Crystals  

SciTech Connect

Experiments were conducted on high purity single and polycrystalline niobium to determine the influence of low concentrations of interstitial impurities on mechanical properties and to evaluate the feasibility of using measurements of mechanical properties to detect, identify, and quantify the diffusible interstitial content.

R. E. Ricker; D. J. Pitchure; and G. R. Myneni

2006-10-30

280

3D Modeling of the Thermal Coagulation Necrosis Induced by an Interstitial Ultrasonic Transducer  

E-print Network

3D Modeling of the Thermal Coagulation Necrosis Induced by an Interstitial Ultrasonic Transducer-operative planning of high intensity ultrasound interstitial targeted therapy. Such approach is mainly aimed therapy, hyperthermia, interstitial therapy, planning, simulation, tis- sue properties. 1 Introduction

Paris-Sud XI, Université de

281

[A case of isoniazid sodium methanesulfonate induced interstitial pneumonia].  

PubMed

A 71-year-old male was admitted to our hospital with dyspnea on effort. He had been prescribed rifampicin, isoniazid sodium methanesulfonate (IHMS), and ethambutol for pulmonary tuberculosis, and ursodesoxycholic acid for alcoholic liver dysfunction. The chest HRCT revealed diffuse ground-glass attenuation with interlobular interstitial thickening. BALF showed lymphocytosis, and TBLB revealed organizing pneumonia. All medications were interrupted, and his respiratory failure and chest HRCT findings were improved. He started again medications excluding IHMS, his condition continued to improve further. DLST to causative IHMS was negative with peripheral blood lymphocytes, but was positive with lymphocytes from BALF. Therefore, we diagnosed this case as having IHMS induced interstitial pneumonia. In the past, 5 cases of isoniazid induced interstitial pneumonia were reported, but IHMS induced interstitial pneumonia has not been reported. Clinicians need to be aware of drug induced interstitial pneumonia by anti-tuberculosis drugs including IHMS in patients receiving anti-tuberculosis drugs. PMID:12806983

Matsushima, Hidekazu; Sugita, Yutaka; Yanagisawa, Tsutomu; Ubukata, Mikio; Kurosawa, Tomonori; Yoshida, Fumika; Kanazawa, Minoru

2003-05-01

282

Chronic interstitial nephritis and mixed cryoglobulinemia associated with drug abuse.  

PubMed

Two cases of chronic interstitial nephritis with renal insufficiency were associated with mixed cryoglobulinemia and parenteral drug abuse. Previously recognized causes of interstitial nephritis were not present in either case. Despite extensive interstitial inflammatory infiltrates, no substantial glomerular abnormalities or immune deposits were present in either patient. One patient had a history of intravenous injection of suspended methadone tablets containing talc crystals, and there was evidence of talc embolization in biopsy specimens of liver, spleen, and kidney. Interstitial nephritis associated with drug abuse has not been previously described to our knowledge, but the association in these cases seems not to have been fortuitous and warrants consideration in the evaluation of both parenteral drug abusers and patients with unexplained interstitial nephritis. PMID:581729

Steinmuller, D R; Bolton, W K; Stilmant, M M; Couser, W G

1979-02-01

283

Nitrogen gas-solid reaction process and basic magnetism of the interstitially modified rare-earth 3d transition-metal nitrides R2Fe17N3 (R=Y, Ce, Nd, Sm) and Y2Co17N3  

Microsoft Academic Search

In this paper, we present our recent results of studies of the nitrogen absorption process, magnetization measurements, and neutron powder-diffraction measurements for interstitially modified nitrides R2Fe17N3 (R=Y, Ce, Nd, and Sm) and Y2Co17N3. (1) The studies of nitrogen absorption rates in the Sm2Fe17 under various N2-gas pressure up to 6 MPa indicated that the nitrogen absorption into grain interior is

Keiichi Koyama; Hironobu Fujii

2000-01-01

284

[Drug-induced interstitial lung diseases].  

PubMed

Drug-induced infiltrative lung disease may manifest as variable clinical radiological patterns, including subacute or chronic interstitial pneumonia, pulmonary fibrosis, eosinophilic pneumonia, organising pneumonia, pulmonary edema, or sarcoidosis. A large amount of drugs have been incriminated, including those used in cardiovascular diseases (amiodarone, statins and angiotensin converting enzyme inhibitors), antibiotics (minocycline, nitrofurantoin), most of anticancer drugs (and especially chemotherapy and chest radiation), treatment of rheumatoid arthritis, as well as more recent drugs. A high index of suspicion is therefore required in any patient with infiltrative lung disease and the web-based tool www.pneumotox.com will help to list possible causative drugs. The following steps are necessary: history and timing of drug exposure, clinical and imaging pattern, exclusion of other causes of infiltrative lung disease, improvement following drug discontinuation. Rechallenge, dangerous, is not recommended. PMID:25362778

Bonniaud, Philippe; Georges, Marjolaine; Favrolt, Nicolas; Camus, Philippe

2014-09-01

285

Respiratory bronchiolitis-associated interstitial lung disease with fibrosis is a lesion distinct from fibrotic nonspecific interstitial pneumonia: a proposal  

Microsoft Academic Search

Nine cases of clinical and radiographic chronic interstitial lung disease are presented that have features of respiratory bronchiolitis-associated interstitial lung disease, but were associated with a respiratory bronchiolitis having extensive paucicellular lamellar eosinophilic collagenous thickening of alveolar septa in a patchy, particularly subpleural distribution. Patients were middle-aged with shortness of breath, mixed obstructive and restrictive lung disease with markedly reduced

Samuel A Yousem

2006-01-01

286

Electro interstitial scan system: assessment of 10 years of research and development  

PubMed Central

Background Ten years of research and development have allowed an understanding of how the electro interstitial scan (EIS) works and what its clinical applications may be. Materials and methods The EIS is a galvanic skin response device. The measurements are performed by electrical stimulation of the post sympathetic cholinergic fiber with weak DC current and voltage 1.28V applied during 2 minutes and in bipolar mode. Current scientific knowledge EIS electrical measurements are related to: (1) the concentration of free chloride ions in the interstitial fluid, which affects the transfer of electrical current and the ratio intensity/voltage; (2) the morphology of the interstitial fluid, which is related to the electrical dispersion calculated from the Cole equation (? parameter); (3) electrical stimulation, which causes a change in sweat rate at the passive electrodes – post sympathetic cholinergic fiber electrical stimulation appears to be responsible for activating M2 receptors, which regulate nitric oxide (NO) production in the endothelial cell and cause vasodilation and a released sweat response; and (4) the electrochemical redox reactions (electrolysis) of the released sweat on electrodes, which are different on the bulk of the metal electrodes (O2 + [4H+] + [4e?]) and on the Ag/AgCl disposable electrodes (AgCl precipitation). Results For each of the EIS clinical results, various explanations were posited, such as: (1) electrical stimulation of the postsympathetic cholinergic fiber-activating NO production in the endothelial cell, which causes vasodilation and a released sweat response (diabetes detection); (2) estimation of interstitial fluid’s acid–base balance, which is reflected in an electrochemical reaction on the bulk of the electrodes through the released sweat (prostate cancer detection); (3) estimation of cerebral interstitial fluid chloride ions (detection of ADHD in children); and (4) estimation of the morphology of the interstitial fluid (selective serotonin reuptake inhibitor treatment response). Conclusion After 10 years of development, the analysis of current scientific knowledge and results of clinical investigations have allowed a better understanding of EIS electrical measurements. PMID:23166454

Maarek, Albert

2012-01-01

287

High-dose-rate interstitial brachytherapy for gynecologic malignancies--dosimetric changes during treatment period  

PubMed Central

To overcome cranio-caudal needle displacement in pelvic high-dose-rate interstitial brachytherapy (HDRIB), we have been utilizing a fullystretched elastic tape to thrust the template into the perineum. The purpose of the current study was to evaluate dosimetric changes during the treatment period using this thrusting method, and to explore reproducible planning methods based on the results of the dosimetric changes. Twenty-nine patients with gynecologic malignancies were treated with HDRIB at the Cancer Institute Hospital. Pre-treatment and post-treatment computed tomography (CT) scans were acquired and a virtual plan for post-treatment CT was produced by applying the dwell positions/times of the original plan. For the post-treatment plan, D90 for the clinical target volume (CTV) and D2cc for the rectum and bladder were assessed and compared with that for the original plan. Cranio-caudal needle displacement relative to CTV during treatment period was only 0.7 ± 1.9 mm. The mean D90 values for the CTV in the pre- and post-treatment plans were stable (6.8 Gy vs. 6.8 Gy) and the post-treatment/pre-treatment D90 ratio was 1.00 ± 0.08. The post-/pre-treatment D2cc ratio was 1.14 ± 0.22 and the mean D2cc for the rectum increased for the post-treatment plan (5.4 Gy vs. 6.1 Gy), especially when parametrial infiltration was present. The mean D2cc for the bladder was stable (6.3 Gy vs. 6.6 Gy) and the ratio was 1.06 ± 0.20. Our thrusting method achieved a stable D90 for the CTV, in contrast to previous prostate HDRIB reports displaying reductions of 35–40% for D90 during the treatment period. PMID:23297319

Onoe, Tsuyoshi; Nose, Takayuki; Yamashita, Hideomi; Yoshioka, Minoru; Toshiyasu, Takashi; Kozuka, Takuyo; Oguchi, Masahiko; Nakagawa, Keiichi

2013-01-01

288

Dynamics and Topography of QUASI-2D Needle-Like Silver Electrochemical Deposits Under a Quasi-Steady Regime  

NASA Astrophysics Data System (ADS)

The electrochemical formation of single silver needles from aqueous silver sulfate was studied under both potentiostatic and galvanostatic conditions utilizing different quasi-2D cells. Under potentiostatic conditions, four (I-IV) stages of growth were distinguished. Stage III involved single needle growth under a quasi-steady-state (q-ss) regime in which, at the millimeter scale, the tip profile remained almost unchanged. Fast growing needles exhibited a truncated quasi-conical tip, and slow growing ones approached prolate hemispheroids. At stage III, the almost constant q-ss silver deposition rate was evaluated from the tip front displacement (dLz/dt) perpendicularly to the tangential plane of the tip. For the cathode to anode potential difference in the range -1.00 ? Ec-a ? -0.22 V, values of (dLz/dt) in the range 0.08-2.0 ?m s-1 were obtained. At the needle stem, the q-ss radial silver deposition rate (dLx/dt) was about two orders of magnitude lower than (dLz/dt). The transition from stage III to IV was characterized by tip thickening, i.e. a change in the tip q-conical profile to that of a prolate hemispheroid, and eventual tip splitting. Scanning electron micrographs at the micrometer scale of single silver needle tips from potentiostatic runs showed either a defined crystallography or an irregular topography covered by a large number of tiny crystals. In contrast, stems were always faceted. This difference indicated that surface relaxation processes following silver ion mass transport and discharge played a relevant role in the needle growth mode. At stage III, the growth regime is described utilizing a dual diffusion (D) and migration (M) model consisting of a DM direct contribution that becomes dominant at the needle stem, and a space charge (SC)-assisted DM contribution that operates at the tip apex. This explanation is consistent with the local cathodic current density values, the concentration ratio of silver clusters at the stem and tip apex surface, and the distinct kinetic behavior of needles produced from potentiostatic and galvanostatic runs. The complex link between mass transport phenomena of silver ions from the binary solution side, the silver ion discharge at the interface and the surface relaxation of silver adatoms and clusters at the metal lattice shed new light on the aspects of single silver needle formation.

Pasquale, M. A.; Vicente, J. L.; Arvia, A. J.

289

78 FR 78296 - Proposed Establishment of Class E Airspace; Needles, CA  

Federal Register 2010, 2011, 2012, 2013

...Establishment of Class E Airspace; Needles, CA AGENCY: Federal Aviation Administration...establish Class E airspace at the Needles VHF Omni-Directional Radio Range Tactical Air Navigation Aid (VORTAC), Needles, CA, to facilitate vectoring...

2013-12-26

290

A compact dynamic force model for needle-tissue interaction  

Microsoft Academic Search

In this paper, the interaction force between a surgical needle and soft tissue is studied. The force is modeled using nonlinear dynamics based on a modified LuGre model that captures all stages of needle-tissue interaction including puncture, cutting, and friction forces. An estimation algorithm for identifying the associated parameters is then presented. This approach, which is based on extended Kalman

Ali Asadian; Mehrdad R. Kermani; Rajni V. Patel

2010-01-01

291

Needle and Syringe Cleaning Practices among Injection Drug Users.  

ERIC Educational Resources Information Center

Evaluates the effect of needle exchange on the bleach-mediated disinfection (BMD) practices of 176 needle and syringe sharing injection drug users (IDUs). Results reveal that IDUs who traded sex for money or drugs were less likely to practice BMD, and IDUs who reported a reduced number of sex partners were more likely to practice BMD. (Contains 36…

Fisher, Dennis G.; Harbke, Colin R.; Canty, John R.; Reynolds, Grace L.

2002-01-01

292

Sugar Micro Needles as Transdermic Drug Delivery System  

Microsoft Academic Search

We designed and fabricated an array of sugar micro needles of the length ranging from 150 ? m to 2 mm for transdermic delivery of drugs. Micro needles were molded out of maltose mixed with pharmaceutical material, being expected bio-degradable in the human skin. To test basic tolerance to the healthy human skin, a clinical experiment was carried out for

Takaya Miyano; Yoshikazu Tobinaga; Takahiro Kanno; Yasushi Matsuzaki; Hitoshi Takeda; Makoto Wakui; Katsumi Hanada

2005-01-01

293

MRI-Guided Vascular Access with an Active Visualization Needle  

PubMed Central

Purpose To develop an approach to vascular access under MRI, as a component of comprehensive MRI-guided cardiovascular catheterization and intervention. Materials and Methods We attempted jugular vein access in healthy pigs as a model of “difficult” vascular access. Procedures were performed under real-time MRI guidance using reduced field of view imaging. We developed an “active” MRI antenna-needle having an open-lumen, distinct tip appearance and indicators of depth and trajectory, in order to enhance MRI visibility during the procedure. We compared performance of the active needle against an unmodified commercial passively-visualized needle, measured by procedure success among operators with different levels of experience. Results MRI-guided central vein access was feasible using both the active needle and the unmodified passive needle. The active needle required less time (88 vs. 244 sec, p=0.022) and fewer needle passes (4.5 vs. 9.1, p=0.028), irrespective of operator experience. Conclusion MRI-guided access to central veins is feasible in our animal model. When image guidance is necessary for vascular access, performing this component under MRI will allow wholly MRI-guided catheterization procedures that do not require adjunctive imaging facilities such as X-ray or ultrasound. The active needle design showed enhanced visibility, as expected. These capabilities may permit more complex catheter-based cardiovascular interventional procedures enabled by enhanced image guidance. PMID:22006552

Saikus, Christina E.; Ratnayaka, Kanishka; Barbash, Israel M.; Colyer, Jessica H.; Kocaturk, Ozgur; Faranesh, Anthony Z.; Lederman, Robert J.

2011-01-01

294

Longitudinal Spinal Organization with Segmental Dominance in Chinese Needle Therapy  

Microsoft Academic Search

Summary The Chinese called it ‘needle therapy’ which the West later interpreted as ‘acupuncture’ based on impossible ideas of energy and blood circulation via invisible meridians introduced in the late 1930s. Lack of understanding the original Chinese discoveries, which made needling a useful therapeutic approach, has made it difficult to correct these misconceptions. Willem ten Rhyne provided the first clues

Donald E. Kendall

2011-01-01

295

Minimizing Hemodialysis Vascular Access Trauma with an Improved Needle Design  

Microsoft Academic Search

The maintenance and longevity of hemodialysis vas- cular access remains one of the most problematic topics in the care of dialysis patients. Although much attention has focused on neointimal hyperplasia, the repetitive trauma to vessel walls by dialysis needles causes significant cumulative damage that has undergone little investigation. Commercial needles have beveled tips with intentional cutting surfaces to ease insertion.

EDWARD A. ROSS; JILL W. VERLANDER; LILIA C. KOO; IRVIN F. HAWKINS

2000-01-01

296

Original article Effects of needle clumping in shoots and crowns  

E-print Network

shape, shoot geometry and needle morphology. Various assumptions about canopy structure (homogeneous of a Norway spruce canopy Alessandro Cescatti Centro di Ecologia Alpina, 38040 Viote del Monte Bondone (TN of needle clumping on the canopy transmittance of a conifer stand are examined using a 3D radiative transfer

Boyer, Edmond

297

Force modeling for needle insertion into soft tissue.  

PubMed

The modeling of forces during needle insertion into soft tissue is important for accurate surgical simulation, preoperative planning, and intelligent robotic assistance for percutaneous therapies. We present a force model for needle insertion and experimental procedures for acquiring data from ex vivo tissue to populate that model. Data were collected from bovine livers using a one-degree-of-freedom robot equipped with a load cell and needle attachment. computed tomography imaging was used to segment the needle insertion process into phases identifying different relative velocities between the needle and tissue. The data were measured and modeled in three parts: 1) capsule stiffness, a nonlinear spring model; 2) friction, a modified Karnopp model; and 3) cutting, a constant for a given tissue. In addition, we characterized the effects of needle diameter and tip type on insertion force using a silicone rubber phantom. In comparison to triangular and diamond tips, a bevel tip causes more needle bending and is more easily affected by tissue density variations. Forces for larger diameter needles are higher due to increased cutting and friction forces. PMID:15490818

Okamura, Allison M; Simone, Christina; O'Leary, Mark D

2004-10-01

298

Observations on rotating needle insertions using a brachytherapy robot  

NASA Astrophysics Data System (ADS)

A robot designed for prostate brachytherapy implantations has the potential to greatly improve treatment success. Much of the research in robotic surgery focuses on measuring accuracy. However, there exist many factors that must be optimized before an analysis of needle placement accuracy can be determined. Some of these parameters include choice of the needle type, insertion velocity, usefulness of the rotating needle and rotation speed. These parameters may affect the force at which the needle interacts with the tissue. A reduction in force has been shown to decrease the compression of the prostate and potentially increase the accuracy of seed position. Rotating the needle as it is inserted may reduce frictional forces while increasing accuracy. However, needle rotations are considered to increase tissue damage due to the drilling nature of the insertion. We explore many of the factors involved in optimizing a brachytherapy robot, and the potential effects each parameter may have on the procedure. We also investigate the interaction of rotating needles in gel and suggest the rotate-cannula-only method of conical needle insertion to minimize any tissue damage while still maintaining the benefits of reduced force and increased accuracy.

Meltsner, M. A.; Ferrier, N. J.; Thomadsen, B. R.

2007-09-01

299

Transport and Transformation of Dissolved Organic Matter in Soil Interstitial Water Across Forested, Montane Hillslopes  

NASA Astrophysics Data System (ADS)

Dissolved organic matter (DOM) is a ubiquitous mixture of compounds formed from the degradation of both terrestrial and microbial material. The abundance and composition of the DOM present in stream water is important to stream processes such as UV light attenuation, nutrient supply and metal sorption. However, an excess of DOM can cause reactions with chlorination compounds at drinking water treatment plants, creating potentially harmful disinfection byproducts. Currently, little is known regarding the influence of soil interstitial water on stream DOM composition. In this study, we explore the role of interstitial water on DOM transport and transformation from the hillslope to the stream in a montane catchment within the Boulder Creek Critical Zone Observatory in Colorado. We installed a suite of tension lysimeters located within the rooting zone across representative north- and south-facing slopes. Interstitial water and stream samples were collected daily for approximately seven weeks during the 2013 spring snow melt period and analyzed for DOM composition using fluorescence spectroscopy. To date, we have used fluorescence index (FI) to evaluate differences between microbial and terrestrial DOM inputs and humification index (HIX) to assess degree of humification undergone by the DOM. Preliminary results indicate that FI was significantly correlated with hillslope aspect (p<.01), with higher FI on north-facing slopes, suggesting more microbial precursor material. Stream samples reveal greater humification throughout the snowmelt period (p<.01). This increase could suggest a transition from deeper groundwater sources to shallow soil interstitial water inputs into the stream during snowmelt. These preliminary results suggest that changes in DOM composition through the catchment during snowmelt can be linked to hydrologic transport. Further site specific model development will reveal explicit changes in the DOM chemistry and will increase our understanding of fundamental nutrient cycling processes at the hillslope to catchment scale.

Burns, M. A.; McKnight, D. M.; Gabor, R. S.; Brooks, P. D.; Barnard, H. R.

2013-12-01

300

Regulation of tumor invasion by interstitial fluid flow  

NASA Astrophysics Data System (ADS)

The importance of the tumor microenvironment in cancer progression is undisputed, yet the significance of biophysical forces in the microenvironment remains poorly understood. Interstitial fluid flow is a nearly ubiquitous and physiologically relevant biophysical force that is elevated in tumors because of tumor-associated angiogenesis and lymphangiogenesis, as well as changes in the tumor stroma. Not only does it apply physical forces to cells directly, but interstitial flow also creates gradients of soluble signals in the tumor microenvironment, thus influencing cell behavior and modulating cell-cell interactions. In this paper, we highlight our current understanding of interstitial fluid flow in the context of the tumor, focusing on the physical changes that lead to elevated interstitial flow, how cells sense flow and how they respond to changes in interstitial flow. In particular, we emphasize that interstitial flow can directly promote tumor cell invasion through a mechanism known as autologous chemotaxis, and indirectly support tumor invasion via both biophysical and biochemical cues generated by stromal cells. Thus, interstitial fluid flow demonstrates how important biophysical factors are in cancer, both by modulating cell behavior and coupling biophysical and biochemical signals.

Shieh, Adrian C.; Swartz, Melody A.

2011-02-01

301

Phase ordering of hard needles on a quasicrystalline substrate.  

PubMed

Quasicrystals possess long-range positional and orientational order. However, they cannot be periodic in space due to their non-crystallographic symmetries such as a 10-fold rotational axis. We perform Monte Carlo simulations of two-dimensional hard-needle systems subject to a quasiperiodic substrate potential. We determine phase diagrams as a function of density and potential strength for two needle lengths. With increasing potential strength short needles tend to form isolated clusters that display directional order along the decagonal directions. Long needles create interacting clusters that stabilize the nematic phase. At large potential strengths the clusters position themselves on two interwoven Fibonacci sequences perpendicular to the cluster orientation. Alternatively, one obtains extended domains of needle clusters which are aligned along all decagonal symmetry directions. PMID:22583263

Kählitz, Philipp; Stark, Holger

2012-05-01

302

Interstitial granulomatous dermatitis associated with chronic inflammatory demyelinating polyneuropathy.  

PubMed

A 44-year-old man presented with an eruption of pruritic erythematous plaques on his lower extremities of 6 months' duration that were unresponsive to antifungal cream or topical corticosteroid. His medical history was notable for chronic inflammatory demyelinating polyneuropathy (CIDP), which was diagnosed 1 year prior to presentation and was associated with lower extremity weakness and imbalance of 3 years' duration. Punch biopsy of lesional skin showed a superficial and deep perivascular and interstitial lymphohistiocytic infiltrate with abundant interstitial neutrophils and rare eosinophils. He was diagnosed with interstitial granulomatous dermatitis (IGD), and the eruption improved with the initiation of oral dapsone 50 mg twice daily. PMID:22908730

Walling, Hobart W; Swick, Brian L

2012-07-01

303

Gallium interstitial contributions to diffusion in gallium arsenide  

NASA Astrophysics Data System (ADS)

A new diffusion path is identified for gallium interstitials, which involves lower barriers than the barriers for previously identified diffusion paths [K. Levasseur-Smith and N. Mousseau, J. Appl. Phys. 103, 113502 (2008), P. A. Schultz and O. A. von Lilienfeld, Modelling and Simulation in Materials Science and Engineering 17, 084007 (2009)] for the charge states which dominate diffusion over most of the available range of Fermi energies. This path passes through the ?110? gallium-gallium split interstitial configuration, and has a particularly low diffusion barrier of 0.35 eV for diffusion in the neutral charge state. As a part of this work, the character of the charge states for the gallium interstitials which are most important for diffusion is investigated, and it is shown that the last electron bound to the neutral interstitial occupies a shallow hydrogenic bound state composed of conduction band states for the hexagonal interstitial and both tetrahedral interstitials. How to properly account for the contributions of such interstitials is discussed for density-functional calculations with a k-point mesh not including the conduction band edge point. Diffusion barriers for gallium interstitials are calculated in all the charge states which can be important for a Fermi level anywhere in the gap, q = 0, +1, +2, and +3, for diffusion via the ?110? gallium-gallium split interstitial configuration and via the hexagonal interstitial configuration. The lowest activation enthalpies over most of the available range of Fermi energies are found to correspond to diffusion in the neutral or singly positive state via the ?110? gallium-gallium split interstitial configuration. It is shown that several different charge states and diffusion paths contribute significantly for Fermi levels within 0.2 eV above the valence band edge, which may help to explain some of the difficulties [H. Bracht and S. Brotzmann, Phys. Rev. B 71, 115216 (2005)] which have been encountered in fitting experimental results for heavily p-type, Ga-rich gallium arsenide by simply extending a model for gallium interstitial diffusion which has been used for less p-doped material.

Schick, Joseph T.; Morgan, Caroline G.

2011-09-01

304

Experimental study of needle-tissue interaction forces: Effect of needle geometries, insertion methods and tissue characteristics.  

PubMed

A thorough understanding of needle-tissue interaction mechanics is necessary to optimize needle design, achieve robotically needle steering, and establish surgical simulation system. It is obvious that the interaction is influenced by numerous variable parameters, which are divided into three categories: needle geometries, insertion methods, and tissue characteristics. A series of experiments are performed to explore the effect of influence factors (material samples n=5 for each factor) on the insertion force. Data were collected from different biological tissues and a special tissue-equivalent phantom with similar mechanical properties, using a 1-DOF mechanical testing system instrumented with a 6-DOF force/torque (F/T) sensor. The experimental results indicate that three basic phases (deformation, insertion, and extraction phase) are existent during needle penetration. Needle diameter (0.7-3.2mm), needle tip (blunt, diamond, conical, and beveled) and bevel angle (10-85°) are turned out to have a great influence on insertion force, so do the insertion velocity (0.5-10mm/s), drive mode (robot-assisted and hand-held), and the insertion process (interrupted and continuous). Different tissues such as skin, muscle, fat, liver capsule and vessel are proved to generate various force cures, which can contribute to the judgement of the needle position and provide efficient insertion strategy. PMID:25169657

Jiang, Shan; Li, Pan; Yu, Yan; Liu, Jun; Yang, Zhiyong

2014-10-17

305

Directional interstitial brachytherapy from simulation to application  

NASA Astrophysics Data System (ADS)

Organs at risk (OAR) are sometimes adjacent to or embedded in or overlap with the clinical target volume (CTV) to be treated. The purpose of this PhD study is to develop directionally low energy gamma-emitting interstitial brachytherapy sources. These sources can be applied between OAR to selectively reduce hot spots in the OARs and normal tissues. The reduction of dose over undesired regions can expand patient eligibility or reduce toxicities for the treatment by conventional interstitial brachytherapy. This study covers the development of a directional source from design optimization to construction of the first prototype source. The Monte Carlo code MCNP was used to simulate the radiation transport for the designs of directional sources. We have made a special construction kit to assemble radioactive and gold-shield components precisely into D-shaped titanium containers of the first directional source. Directional sources have a similar dose distribution as conventional sources on the treated side but greatly reduced dose on the shielded side, with a sharp dose gradient between them. A three-dimensional dose deposition kernel for the 125I directional source has been calculated. Treatment plans can use both directional and conventional 125I sources at the same source strength for low-dose-rate (LDR) implants to optimize the dose distributions. For prostate tumors, directional 125I LDR brachytherapy can potentially reduce genitourinary and gastrointestinal toxicities and improve potency preservation for low risk patients. The combination of better dose distribution of directional implants and better therapeutic ratio between tumor response and late reactions enables a novel temporary LDR treatment, as opposed to permanent or high-dose-rate (HDR) brachytherapy for the intermediate risk T2b and high risk T2c tumors. Supplemental external-beam treatments can be shortened with a better brachytherapy boost for T3 tumors. In conclusion, we have successfully finished the design optimization and construction of the first prototype directional source. Potential clinical applications and potential benefits of directional sources have been shown for prostate and breast tumors.

Lin, Liyong

306

Pulmonary actinomycosis in fine needle aspiration cytology  

PubMed Central

Pulmonary actinomycosis is a rare bacterial lung disease caused by one of two types of bacteria, Actinomyces or Propioni. Pulmonary actinomycosis in the lung causes lung cavities, lung nodules, and pleural effusion. We report here a case of pulmonary actinomycosis that was diagnosed by fine needle aspiration cytology (FNAC). A 45 year-old male with a history of smoking and alcohol abuse, presented with complaints of cough with hemoptysis, right-sided chest pain, and fever of two months’ duration. A chest radiograph and computed tomography (CT) of the thorax showed a right upper lobe mass lesion with hilar lymphadenopathy. CT-guided FNAC revealed colonies of Actinomyces surrounded by polymorphs. The disease is commonly confused with other chronic suppurative lung diseases and malignancy. An early diagnosis by FNAC prevents difficulties in the management of the disease, as well as considerable physiological and physical morbidity, including unwarranted surgery. PMID:21938164

Patel, Keyuri B; Gupta, Gurudutt; Shah, Menka; Patel, Purvesh

2009-01-01

307

Pulmonary actinomycosis in fine needle aspiration cytology.  

PubMed

Pulmonary actinomycosis is a rare bacterial lung disease caused by one of two types of bacteria, Actinomyces or Propioni. Pulmonary actinomycosis in the lung causes lung cavities, lung nodules, and pleural effusion. We report here a case of pulmonary actinomycosis that was diagnosed by fine needle aspiration cytology (FNAC). A 45 year-old male with a history of smoking and alcohol abuse, presented with complaints of cough with hemoptysis, right-sided chest pain, and fever of two months' duration. A chest radiograph and computed tomography (CT) of the thorax showed a right upper lobe mass lesion with hilar lymphadenopathy. CT-guided FNAC revealed colonies of Actinomyces surrounded by polymorphs. The disease is commonly confused with other chronic suppurative lung diseases and malignancy. An early diagnosis by FNAC prevents difficulties in the management of the disease, as well as considerable physiological and physical morbidity, including unwarranted surgery. PMID:21938164

Patel, Keyuri B; Gupta, Gurudutt; Shah, Menka; Patel, Purvesh

2009-04-01

308

Intracranially Retained Sewing Needle in a Child: Does the Rust on the Needle Have any Implication?  

Microsoft Academic Search

A penetrating injury with a sewing needle is a rare phenomenon. The pathophysiological mechanism of late epilepsy after penetrating\\u000a injuries is not clear. A 10-year-old female child had a seizure. An X-ray study of the skull and the cranial computed tomography\\u000a scans showed a foreign object retained in the skull cavity. She was intact on neurological examination. Electroencephalogram\\u000a (EEG) showed

Naci Balak; Güçlühan Güçlü; Ismail Karaca; Sema Aksoy

2008-01-01

309

Adequate histologic sectioning of prostate needle biopsies.  

PubMed

No standard method exists for sampling prostate needle biopsies, although most reports claim to embed 3 cores per block and obtain 3 slices from each block. This study was undertaken to determine the extent of histologic sectioning necessary for optimal examination of prostate biopsies. We prospectively compared the impact on cancer yield of submitting 1 biopsy core per cassette (biopsies from January 2010) with 3 cores per cassette (biopsies from August 2010) from a large national reference laboratory. Between 6 and 12 slices were obtained with the former 1-core method, resulting in 3 to 6 slices being placed on each of 2 slides; for the latter 3-core method, a limit of 6 slices was obtained, resulting in 3 slices being place on each of 2 slides. A total of 6708 sets of 12 to 18 core biopsies were studied, including 3509 biopsy sets from the 1-biopsy-core-per-cassette group (January 2010) and 3199 biopsy sets from the 3-biopsy-cores-percassette group (August 2010). The yield of diagnoses was classified as benign, atypical small acinar proliferation, high-grade prostatic intraepithelial neoplasia, and cancer and was similar with the 2 methods: 46.2%, 8.2%, 4.5%, and 41.1% and 46.7%, 6.3%, 4.4%, and 42.6%, respectively (P = .02). Submission of 1 core or 3 cores per cassette had no effect on the yield of atypical small acinar proliferation, prostatic intraepithelial neoplasia, or cancer in prostate needle biopsies. Consequently, we recommend submission of 3 cores per cassette to minimize labor and cost of processing. PMID:23764163

Bostwick, David G; Kahane, Hillel

2013-08-01

310

Approaches for modeling interstitial ultrasound ablation of tumors within or adjacent to bone: Theoretical and experimental evaluations  

PubMed Central

Purpose The objectives of this study were to develop numerical models of interstitial ultrasound ablation of tumors within or adjacent to bone, to evaluate model performance through theoretical analysis, and to validate the models and approximations used through comparison to experiments. Methods 3D transient biothermal and acoustic finite element models were developed, employing four approximations of 7 MHz ultrasound propagation at bone/soft tissue interfaces. The various approximations considered or excluded reflection, refraction, angle-dependence of transmission coefficients, shear mode conversion, and volumetric heat deposition. Simulations were performed for parametric and comparative studies. Experiments within ex vivo tissues and phantoms were performed to validate the models by comparison to simulations. Temperature measurements were conducted using needle thermocouples or MR temperature imaging (MRTI). Finite element models representing heterogeneous tissue geometries were created based on segmented MR images. Results High ultrasound absorption at bone/soft tissue interfaces increased the volumes of target tissue that could be ablated. Models using simplified approximations produced temperature profiles closely matching both more comprehensive models and experimental results, with good agreement between 3D calculations and MRTI. The correlation coefficients between simulated and measured temperature profiles in phantoms ranged from 0.852 to 0.967 (p-value < 0.01) for the four models. Conclusions Models using approximations of interstitial ultrasound energy deposition around bone/soft tissue interfaces produced temperature distributions in close agreement with comprehensive simulations and experimental measurements. These models may be applied to accurately predict temperatures produced by interstitial ultrasound ablation of tumors near and within bone, with applications toward treatment planning. PMID:24102393

Scott, Serena J.; Prakash, Punit; Salgaonkar, Vasant; Jones, Peter D.; Cam, Richard N.; Han, Misung; Rieke, Viola; Burdette, E. Clif; Diederich, Chris J.

2014-01-01

311

Microarterial synthetic graft repair: interstitial cellular components.  

PubMed

Although the histologic changes occurring during healing on the lumen surface of large vessel synthetic vascular grafts have been well characterized, the cells populating the interstices of microvascular grafts have not been examined in detail. Since microvascular grafts are required to provide vascular continuity under quite different physiological and hemodynamic conditions as compared with large vessel grafts, these interstitial cells within the synthetic graft material may also vary as a function of graft size. Monoclonal antibodies, light microscopy, and scanning and transmission electron microscopy were used in this study to identify the cells present within the 30-microns pores of 1-mm diameter polytetrafluoroethylene and replamineform silicone rubber grafts. Identified cells included few capillary endothelial cells enclosing erythrocytes, rare proliferating endothelial cells, few macrophages, rare foreign body giant cells, and a majority of fibroblasts. There was no evidence of smooth muscle cells or myofibroblasts within the interstices of these microvascular prostheses 12 weeks after implantation in the rabbit central ear artery. The graft types differed by the presence of foreign body giant cells and more densely packed collagen between cells in the replamineform silicone rubber graft interstices. PMID:2255244

Joos, K M; Sandra, A

1990-01-01

312

Acute interstitial nephritis induced by Dioscorea quinqueloba  

PubMed Central

Background The use of herbal medicine may be a risk factor for the development of kidney injury, as it has been reported to cause various renal syndromes. Dioscorea quinqueloba is a medicinal herb that is used as an alternative therapy for cardiovascular disease and various medical conditions. Case presentation A 52-year-old man was admitted with complaints of skin rash and burning sensation. He had ingested a raw extract of D. quinqueloba as a traditional remedy. Laboratory tests revealed the following values: absolute eosinophil count, 900/mm3; serum creatinine level, 2.7 mg/dL; and blood urea nitrogen, 33.0 mg/dL. The immunoglobulin E level was markedly increased at 1320.0 IU/mL. Urinalysis revealed a fractional excretion of sodium of 3.77%, protein 1+, and blood 3+. Histological examination of the renal biopsy specimen showed a diffusely edematous interstitium with infiltrates composed of eosinophils, lymphocytes, and neutrophils. Conclusion Here, we present the first reported case of biopsy-proven acute interstitial nephritis following ingestion of D. quinqueloba associated with skin rash, eosinophilia, and increased plasma immunoglobulin E level. PMID:25186588

2014-01-01

313

Treatment of interstitial lung disease in children.  

PubMed

The treatment of interstitial lung disease in children depends on the nature of the underlying pathology. In approximately 50% of cases a specific aetiology can be found such as: chronic viral infection, an auto-immune process, sarcoidosis or alveolar proteinosis. In the remainder, the process is idiopathic and the pathological findings are based on the descriptive morphological features seen in the diagnostic lung biopsy. If a specific cause is found then targeted treatment with antivirals, steroids or other immunosuppressive agents is available. Alveolar proteinosis can be treated by bronchial lavage and GM-CSF. Idiopathic cases are treated primarily with intravenous pulsed methylprednisolone or oral prednisolone backed up hydroxychloroquine. Other immunosuppressive agents such as azathioprine, methotrexate or ciclosporin have been used successfully in individual patients. The prognosis is very variable and includes no response to any therapy, partial response with chronic long term morbidity, to virtually complete recovery. The overall mortality rate is 15%. There are no controlled therapeutic trials available because of the rarity of these conditions in childhood. Unlike in adult practice, no correlation has as yet been demonstrated between the initial pattern of chest x-ray change or the degree of pathological change on the lung biopsy and the clinical outcome. The recurrence rate within families is 1 in 8. PMID:15135120

Dinwiddie, R

2004-06-01

314

Nilotinib-induced interstitial lung disease.  

PubMed

Nilotinib is a second-generation tyrosine kinase inhibitor active in patients with chronic myeloid leukemia (CML) resistant to imatinib, and has been recently approved for newly diagnosed patients. We present a case of nilotinib-induced interstitial lung disease (ILD). A 67-year-old female patient was initially treated with imatinib for chronic-phase Philadelphia chromosome-positive (Ph(+)) CML. Imatinib was replaced by nilotinib because of hematological toxicity. The patient had received nilotinib for about 3 years without significant adverse effects. She visited the clinic due to chronic cough; chest X-ray revealed consolidations in both lung fields. Nilotinib-induced ILD was diagnosed based on intensive workup, including lung biopsy. She responded dramatically to corticosteroid therapy. To our knowledge, this is the first reported case of nilotinib-induced ILD in a patient with Ph(+) CML. We emphasize that if unexplained lung abnormalities progress in patients receiving nilotinib, physicians should consider this potentially fatal complication in their differential diagnoses. PMID:23877149

Go, Se-Il; Lee, Won Sup; Lee, Gyeong-Won; Kang, Jung Hun; Kang, Myung Hee; Lee, Jeong-Hee; Kim, Hoon-Gu

2013-09-01

315

Interstitial laser photocoagulation of uterine leimyoma  

NASA Astrophysics Data System (ADS)

Uterine leiomyomas (fibroids) are common benign tumors which may cause heavy or painful periods, may present as a pelvic mass and are associated with infertility. Local excision of symptomatic lesions can be difficult and hazardous, and the alternative is hysterectomy. We are investigating interstitial laser photocoagulation (ILP) as a less invasive alternative. Initial experiments were undertaken on 40 fibroids after surgical removal. One or two bare tipped, precharred fibers from a 25 W semiconductor laser (805 nm) were inserted into the center of the fibroid and treatment delivered with 2 - 10 W for 100 - 1000 sec. Specimens were subsequently sectioned perpendicular to the fiber track. Fibroids are very pale and apart from occasional charred tracts there was little evidence of thermal coagulation macroscopically or after haematoxylon and eosin staining. However, using a diaphorase stain technique we were able to demonstrate ellipsoid zones of devitalized tissue up to 20 mm across (15 mm for single fibers). These results suggest that ILP is producing gentle, uniform coagulation which could lead to resorption of treated areas. With appropriate numbers of treatment sites, this could permit minimally invasive management of clinically significant lesions. Clinical studies have commenced treating fibroids with ILP at the time of surgical excision by myomectomy or hysterectomy.

Gordon, Alastair D.; Buonaccorsi, Giovanni A.; Patel, Bipin L.; Broadbent, Jeff J.; Thurrell, Wendy; Bown, Stephen G.

1996-01-01

316

Self-Interstitial Transport in Vanadium  

SciTech Connect

We study the diffusion of self-interstitial atoms (SIAs) and SIA clusters in vanadium via molecular dynamics simulations with an improved Finnis-Sinclair potential (fit to first-principles results for SIA structure and energetics). The present results demonstrate that single SIAs exist in a <111>-dumbbell configuration and migrate easily along <111> directions. Changes of direction through rotations into other <111> directions are infrequent at low temperatures, but become prominent at higher temperatures, thereby changing the migration path from predominantly one-dimensional to almost isotropically three-dimensional. SIA clusters (i.e., clusters of <111>-dumbbells) can be described as perfect prismatic dislocation loops with Burgers vector and habit planes of 1/2<111>{l_brace}220{r_brace} that migrate only along their glide cylinder. SIA clusters also migrate along <111>-directions, but do not rotate. Both single SIAs and their clusters exhibit a highly non-Arrhenius diffusivity, which originates from a combination of a temperature dependent correlation factor and the presence of very low migration barriers. At low temperature, the diffusion is approximately Arrhenius, while above room temperature, the diffusivity is a linear function of temperature. A simple model is proposed to describe these diffusion regimes and the transition between them.

Zepeda-Ruiz, L A; Rottler, J; Wirth, B D; Car, R; Srolovitz, D J

2005-01-13

317

Granular Material Flows with Interstitial Fluid Effects  

NASA Technical Reports Server (NTRS)

The research focused on experimental measurements of the rheological properties of liquid-solid and granular flows. In these flows, the viscous effects of the interstitial fluid, the inertia of the fluid and particles, and the collisional interactions of the particles may all contribute to the flow mechanics. These multiphase flows include industrial problems such as coal slurry pipelines, hydraulic fracturing processes, fluidized beds, mining and milling operation, abrasive water jet machining, and polishing and surface erosion technologies. In addition, there are a wide range of geophysical flows such as debris flows, landslides and sediment transport. In extraterrestrial applications, the study of transport of particulate materials is fundamental to the mining and processing of lunar and Martian soils and the transport of atmospheric dust (National Research Council 2000). The recent images from Mars Global Surveyor spacecraft dramatically depict the complex sand and dust flows on Mars, including dune formation and dust avalanches on the slip-face of dune surfaces. These Aeolian features involve a complex interaction of the prevailing winds and deposition or erosion of the sediment layer; these features make a good test bed for the verification of global circulation models of the Martian atmosphere.

Hunt, Melany L.; Brennen, Christopher E.

2004-01-01

318

Nonspecific interstitial pneumonia and usual interstitial pneumonia: comparison of the clinicopathologic features and prognosis  

PubMed Central

Background Nonspecific interstitial pneumonia (NSIP) has recently been proposed as a histologic type of idiopathic interstitial pneumonia (IIP), but its broad spectrum of clinicopathologic findings and variable prognosis are poorly understood. It is particularly unclear how NSIP and usual interstitial pneumonia (UIP) are related. The present study investigated the clinicopathologic features and prognosis of NSIP, and its differential diagnosis from UIP. Methods The clinicopathologic findings and prognosis in 21 NSIP and 18 UIP patients who underwent surgical or video-assisted thoracoscopic lung biopsy were reviewed. Results NSIP was more frequent in women and showed nonspecific clinical manifestations. High-resolution computed tomography (HRCT) demonstrated ground-glass, net-like, and patchy attenuation in both lungs. Semiquantitative HRCT showed a median fibrosis score of 3 (range, 0 to 7) in NSIP patients and 5 (range, 2 to 7) in UIP patients (P<0.01). On histopathologic examination, NSIP cases were heterogeneous and the findings could be categorized into cellular and fibrosing patterns. The mean age of the NSIP and UIP patients was 48 and 60 years, respectively. The frequencies of fibroblast foci, myogelosis, honeycomb lesions, and pulmonary structural destruction in NSIP and UIP patients were 16.7% and 100% (P<0.001), 22.2% and 85.7% (P<0.05), 16.7% and 92.9% (P<0.001), and 27.8% and 100% (P<0.05), respectively. The responses to glucocorticoid treatment and the prognosis were significantly greater in NSIP than those in UIP. Conclusions NSIP was difficult to be differentiated from UIP by general clinical manifestations, but HRCT can be helpful for this purpose. Definitive diagnosis depends on the results of surgical lung biopsy. PMID:25364525

Xu, Jinfu; Liu, Jinming; Yi, Xianghua; Sun, Xiwen; Shi, Jingyun

2014-01-01

319

Long term follow-up of patients with Cushing's disease treated by interstitial irradiation  

SciTech Connect

The first 86 patients with Cushing's disease treated with interstitial irradiation (by needle implantation) as the sole therapy were reviewed. In the 82 patients who were reassessed 1 yr after treatment 63 (77%) achieved remission. This study comprises the outcome and complications in the 54 patients who had a remission and whom we were able to follow. The follow-up period ranged from 3-26 yr (mean, 10.5) from the time of remission. No instance of clinical or radiological relapse has occurred. Of these 54 patients, yttrium-90 alone was used in 32, of whom 12 (37%) required corticosteroid or T4 replacement therapy in a mean time of 3.5 months; in 7 of these 12 we elected to give an ablative dose. Gold-198 alone was used in 15 patients, of whom 7 (47%) developed hypopituitarism in a mean time of 76 months. Both isotopes were used in 7 patients. A diurnal serum cortisol rhythm was found in 28 of the 31 patients who were not receiving corticosteroid therapy. In 5 of the 7 patients with an initially abnormal pituitary fossa, serial radiological studies revealed remodelling in 3. There have been no complications in the last 17 years. Pituitary implantation with yttrium-90 is an effective alternative to transsphenoidal hypophysectomy, with a high remission rate, no recurrence (as yet), no operative complications, and avoidance of hormone replacement in the majority.

Sandler, L.M.; Richards, N.T.; Carr, D.H.; Mashiter, K.; Joplin, G.F.

1987-09-01

320

Localized acquired cutis laxa secondary to interstitial granulomatous dermatitis.  

PubMed

We report the case of a 68-year-old woman who had interstitial granulomatous dermatitis associated with seronegative polyarthritis. Two years later, this had evolved to become localized acquired cutis laxa. PMID:19438565

Lucas, A; Bañuls, J; Mataix, J; Pérez-Crespo, M; Jiménez, M J; Botella, R; Betlloch, I

2009-07-01

321

View of first level from north showing interstitial structural columns ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View of first level from north showing interstitial structural columns for the Shuttle assemble configuration. - Marshall Space Flight Center, Saturn V Dynamic Test Facility, East Test Area, Huntsville, Madison County, AL

322

Dynamics of self-interstitial cluster formation in silicon  

NASA Astrophysics Data System (ADS)

Energy barriers and rebonding effects associated with the formation of silicon di- and tri-interstitial clusters are examined using the pseudopotential plane wave technique. For both defects we report two distinctive metastable configurations. We elucidate in detail the structural differences of these configurations and the method of their formation from single interstitials. The electronic bond topology using the quantum theory of atoms in molecules [R. F. W. Bader, Atoms in Molecules. A Quantum Theory, Vol. 22 of International Series of Monographs on Chemistry (Oxford University Press, Oxford, 1990)] reveals that in general stronger bonds correspond to shorter interatomic distances. However, exceptions occur when the distances exceed the perfect bond distance (>2.5 Å). Furthermore, no barrier exists during the capture of the interstitial during the formation process. This indicates a high probability of capture of a self-interstitial, once it wanders within a radius of 4.1 Å of a defect cluster.

Chichkine, M. P.; de Souza, M. M.

2002-07-01

323

CT in the diagnosis of interstitial lung disease  

SciTech Connect

The computed tomographic (CT) appearance of interstitial lung disease was assessed in 23 patients with known interstitial disease. These included seven patients with fibrosing alveolitis, six with silicosis, two with hypersensitivity pneumonitis, three with lymphangitic spread of tumor, two with sarcoidosis, one with rheumatoid lung disease, and two with neurofibromatosis. The CT appearance of the interstitial changes in the different disease entities was assessed. Nodules were a prominent CT feature in silicosis, sarcoidosis, and lymphangitic spread of malignancy. Distribution of nodules and associated interlobular septal thickening provided further distinguishing features in these diseases. Reticular densities were the predominant CT change in fibrosing alveolitis, rheumatoid lung disease, and extrinsic allergic alveolitis. CT can be useful in the investigation of selected instances of interstitial pulmonary disease.

Bergin, C.J.; Mueller, N.L.

1985-09-01

324

Effects of interstitial flow on tumor cell migration  

E-print Network

Interstitial flow is the convective transport of fluid through tissue extracellular matrix. This creeping fluid flow has been shown to affect the morphology and migration of cells such as fibroblasts, cancer cells, endothelial ...

Polacheck, William J. (William Joseph)

2010-01-01

325

Needle steering for robot-assisted insertion into soft tissue: A survey  

NASA Astrophysics Data System (ADS)

Needle insertion is a common surgical procedure used in diagnosis and treatment. The needle steering technologies make continuous developments in theoretical and practical aspects along with the in-depth research on needle insertion. It is necessary to summarize and analyze the existing results to promote the future development of theories and applications of needle insertion. Thus, a survey of the state of the art of research is presented on algorithms of needle steering techniques, the surgical robots and devices. Based on the analysis of the needle insertion procedure, the concept of needle steering is defined as a kinematics problem, which is to place the needle at the target and avoid the obstacles. The needle steering techniques, including the artificial potential field method and the nonholonomic model, are introduced to control the needles for improving the accuracy. Based on the quasi-static thinking, the virtual spring model and the cantilever-beam model are developed to calculate the amount of needle deflection and generate the needle path. The phantoms instead of the real tissue are used to verify the models mentioned in most of the experimentations. For the desired needle trajectories, the image-guided robotic devices and some novel needles are presented to achieve the needle steering. Finally, the challenges are provided involving the controllability of the long flexible needle and the properties of soft tissue. The results and investigations can be used for further study on the precision and accuracy of needle insertion.

Gao, Dedong; Lei, Yong; Zheng, Haojun

2012-07-01

326

Interstitial Sn 2+ in synthetic and natural cassiterite crystals  

Microsoft Academic Search

Evidence for the presence of Sn2+ in an octahedral interstitial site in synthetic and natural cassiterite (SnO2) is presented. The absorption and relative absorption spectral peaks measured are similar to ones found in Sn2+-doped KI by absorption spectrophotometry and Sn2+-doped soda-silica glass by reflection spectroscopy. The estimated quantity of interstitial Sn2+ present is found by calculating that needed to balance

Alvin J. Cohen; Jacob I. D. Adekeye; Bruce Hapke; Deborah P. Partlow

1985-01-01

327

Interstitial and substitutional zirconium in SrTiO3  

SciTech Connect

We investigate Zr in SrTiO3 (STO) as a model for nuclear waste forms in which the fission product Sr90 eventually decays to stable Zr through beta emission. The transformation of a divalent into a tetravalent constituent is expected to affect the long-term structural and chemical stability of this solid. Computational methods of electronic structure theory, specifically the density functional theory (DFT) within the supercell model, are used to predict the thermodynamic stability and electronic states of interstitial and Sr- or Ti-substituted Zr atoms in the STO lattice. Native defects such as vacancies and antisites are also considered. When Zr replaces Sr, its most stable configuration is to simply occupy the Sr site (instead of, for example, replacing a Ti and displacing the Ti to the Sr site.) For Zr added to the lattice, its most stable configuration is to replace a Ti, making a ZrTi impurity plus a Ti interstitial (as opposed to the Zr just remaining as an interstitial atom.) ZrSr is predicted to be a double electron donor, ZrTi is electrically inactive and interstitial Zr and Ti are predicted to be quadruple donors, with all donor levels in the conduction band. ZrSr and the tetravalent interstitials are all predicted to increase the crystal volume, and the interstitials also are predicted to lead to a tetragonal distortion of the lattice. Experiments with injection of Zr atoms into STO qualitatively confirm these predictions of crystal structural changes.

Jaffe, John E.; Van Ginhoven, Renee M.; Jiang, Weilin

2012-02-22

328

Idiopathic interstitial pneumonias: progress in classification, diagnosis, pathogenesis and management.  

PubMed Central

The idiopathic interstitial pneumonias are a heterogeneous group of poorly understood diseases with often devastating consequences for those afflicted. Subclassification of the idiopathic interstitial pneumonia based on clinical-radiological-pathological criteria has highlighted important pathogenic, therapeutic and prognostic implications. The most critical distinction is the presence of usual interstitial pneumonia, the histopathological pattern seen in idiopathic pulmonary fibrosis. Idiopathic pulmonary fibrosis has a worse response to therapy and prognosis. New insight into the pathophysiology of usual interstitial pneumonia suggests a distinctly fibroproliferative process, and antifibrotic therapies show promise. While the clinical and radiographic diagnosis of idiopathic interstitial pneumonias can be made confidently in some cases, many patients require surgical lung biopsy to determine their underlying histopathology. A structured, clinical-radiological-pathological approach to the diagnosis of the idiopathic interstitial pneumonias, with particular attention to the identification of idiopathic pulmonary fibrosis, insures proper therapy, enhances prognostication, and allows for further investigation of therapies aimed at distinct pathophysiology. Images Fig. 2 Fig. 4 Fig. 5 Fig. 6 PMID:17060957

King, Talmadge E.

2004-01-01

329

Computer Simulations of Interstitial Loop Growth Kinetics in irradiated bcc Fe  

SciTech Connect

The growth kinetics of (001) [001] interstitial loops in bcc Fe is studied by phase-field modeling. The effect of defect (vacancy/interstitial) concentration, generation, recombination, sink strength, and elastic interaction on the growth kinetics of interstitial loops is systematically simulated. Results show that the elastic interaction between the defects and interstitial loops speeds up the growth kinetics and affects the morphology of the interstitial loops. Linear growth rate, i.e., the loop average radius is linear to time, under both aging and irradiation are predicted, which is in agreement with experimental observation. The results also show that the interstitial loop growth rate, which is directly related to the sink strength of the interstitial loop for interstitials, increases linearly with the initial interstitial concentration during aging while changing logarithmically with the interstitial generation rate under irradiation.

Li, Yulan; Hu, Shenyang Y.; Henager, Charles H.; Deng, Huiqiu; Gao, Fei; Sun, Xin; Khaleel, Mohammad A.

2012-08-01

330

Diagenesis of conifer needles in a coastal marine environment  

NASA Astrophysics Data System (ADS)

Physically intact fir, hemlock and cedar needles were isolated from different horizons of a sediment core from a coastal marine bay (Dabob Bay, Washington State, U.S.A.) and from nearby trees and forest litter. Green fir, hemlock and cedar needles were all characterized by glucose-rich aldose mixtures (~30% of tissue carbon), the production of vanillyl and cinnamyl CuO-derived phenols (~8% of tissue carbon) and the presence of both pinitol and myo-inositol (1-2% of tissue carbon). Needles from forest litter were enriched in lignin phenols and non-glucose aldoses and depleted in glucose and cyclitols. The sediment core contained an average of 10 mg/1 of physically intact fir, hemlock and cedar needles, which occurred in similar relative abundances and accounted for less than 1% of the total nonwoody gymnosperm tissue. Compared to the green and litter counterparts, all sedimentary needles were greatly depleted in cyclitols, glucose and p-coumaric acid and enriched in vanillyl phenol precursors. The degree of elevation of vanillyl phenol yield from the degraded needles was used to estimate minimal carbon losses from the samples, which ranged from near 40% for needle litter to almost 70% for the deepest (~100 years old) sedimentary fir/hemlock samples. Although downcore increases in carbon loss and refractory organic components indicated in situ diagenesis, the bulk of overall degradation occurred either on land or during the first 10-20 years after deposition. Atomic C/N ratios of degraded needles were lower than for green counterparts, but nitrogen was lost overall. These relative changes indicate the following stability series: vanillyl phenols > N > ferulic acid, p-hydroxy phenols, most aldoses and bulk tissue > glucose and p-coumaric acid > cyclitols (near 100% loss). Vanillic acid to vanillin ratios, (Ad/Al)v, of the green fir and hemlock needles were unusually high (0.36-0.38) and decreased downcore. Diagenesis also decreased the cinnamyl/vanillyl phenol ratio (C/V) of the deepest sedimentary fir/hemlock needles to 20% of the original value and almost tripled the carbon-normalized yield of total vanillyl plus cinnamyl phenols (?). The net result of these compositional variations was to make the lignin component of the buried conifer needles resemble lignin in gymnosperm wood, thereby leading to underestimates of needle input and mass.

Hedges, John I.; Weliky, K.

1989-10-01

331

Robotic Image-Guided Needle Interventions of the Prostate  

PubMed Central

Prostate biopsy and needle-directed prostate therapies are currently performed free-handed or with needle external templates under ultrasound guidance. Direct image-guided intervention robots are modern instruments that have the potential to substantially enhance these procedures. These may increase the accuracy and repeatability with which needles are placed in the gland. The authors’ group has developed a robot for precise prostate targeting that operates remotely alongside the patient in the magnetic resonance imaging scanner, as guided according to the image. PMID:19390670

Mozer, Pierre C; Partin, Alan W; Stoianovici, Dan

2009-01-01

332

Surface morphology and electrical transport of rapid thermal annealed chromium-doped indium zinc oxides: The influence of zinc interstitials and out-diffusion  

NASA Astrophysics Data System (ADS)

We investigate the complex impedance (CI) spectra of chromium-doped indium zinc oxide (CIZO) films with different rapid thermal annealing (RTA) temperatures. The CI spectra drawn from the impedance contributions of Zn-O and In-O bondings in CIZO films were analyzed by two sets of parallel resistance and capacitance components in series. The result demonstrates that zinc interstitials controls electron concentration and transition of electrical transport from semiconducting to metallic. At higher RTA temperature, high-density zinc interstitial promotes Zn atom diffusion from the surface, modifying surface morphology.

Hsu, C. Y.

2013-12-01

333

Surface morphology and electrical transport of rapid thermal annealed chromium-doped indium zinc oxides: The influence of zinc interstitials and out-diffusion  

SciTech Connect

We investigate the complex impedance (CI) spectra of chromium-doped indium zinc oxide (CIZO) films with different rapid thermal annealing (RTA) temperatures. The CI spectra drawn from the impedance contributions of Zn-O and In-O bondings in CIZO films were analyzed by two sets of parallel resistance and capacitance components in series. The result demonstrates that zinc interstitials controls electron concentration and transition of electrical transport from semiconducting to metallic. At higher RTA temperature, high-density zinc interstitial promotes Zn atom diffusion from the surface, modifying surface morphology.

Hsu, C. Y., E-mail: cyhsu00@gmail.com [Physics Department, National Sun Yat-Sen University, Kaohsiung 804, Taiwan (China)

2013-12-09

334

Transbronchial Needle Injection: A Systematic Review of a New Diagnostic and Therapeutic Paradigm  

Microsoft Academic Search

Background and Objective: Transbronchial needle catheters are commonly used during flexible and rigid bronchoscopy for needle aspiration. The use of these catheters can be expanded by employing the technique of transbronchial needle injection. Methods and Results: By injecting lesions in the airways, peribronchial structures, mediastinum, or lung parenchyma, transbronchial needle injection has been applied to the treatment of lung cancer,

Christopher W. Seymour; William S. Krimsky; Jeffrey Sager; Robert J. Kruklitis; Mark E. Lund; Ali I. Musani; Daniel H. Sterman

2006-01-01

335

Motion Planning Under Uncertainty for Image-guided Medical Needle Steering  

Microsoft Academic Search

We develop a new motion planning algorithm for a vari- ant of a Dubins car with binary left\\/right steering and apply it to steerable needles, a new class of exible bevel- tip medical needles that physicians can steer through soft tissue to reach clinical targets inaccessible to traditional sti needles. Our method explicitly considers uncertainty in needle motion due to

Ron Alterovitz; Michael S. Branicky; Kenneth Y. Goldberg

2008-01-01

336

21 CFR 880.5570 - Hypodermic single lumen needle.  

...ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL HOSPITAL AND PERSONAL USE DEVICES General Hospital and Personal Use Therapeutic Devices § 880.5570 Hypodermic single lumen needle....

2014-04-01

337

Miniature oxygen-hydrogen cutting torch constructed from hypodermic needle  

NASA Technical Reports Server (NTRS)

A miniature cutting torch consisting of a main body member, upon which the hydrogen and oxygen containers are mounted, valves for controlling gas flow, and a hypodermic needle that acts as a mixing tube and flame tip is constructed.

Shlichta, P.

1964-01-01

338

10. NEEDLE SHOWER IN COOLING ROOM. Hot Springs National ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. NEEDLE SHOWER IN COOLING ROOM. - Hot Springs National Park, Bathhouse Row, Fordyce Bathhouse: Mechanical & Piping Systems, State Highway 7, 1 mile north of U.S. Highway 70, Hot Springs, Garland County, AR

339

9. NEEDLE SHOWER IN MEN'S PACK ROOM. Hot Springs ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. NEEDLE SHOWER IN MEN'S PACK ROOM. - Hot Springs National Park Bathhouse Row, Maurice Bathhouse: Mechanical & Piping Systems, State Highway 7, 1 mile north of U.S. Highway 70, Hot Springs, Garland County, AR

340

10. NEEDLE SHOWER IN WOMEN'S PACK ROOM. Hot Springs ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. NEEDLE SHOWER IN WOMEN'S PACK ROOM. - Hot Springs National Park, Bathhouse Row, Lamar Bathhouse: Mechanical & Piping Systems, State Highway 7, 1 mile north of U.S. Highway 70, Hot Springs, Garland County, AR

341

21 CFR 878.5350 - Needle-type epilator.  

Code of Federal Regulations, 2012 CFR

...FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5350 Needle-type epilator. (a) Identification. A...

2012-04-01

342

21 CFR 878.5350 - Needle-type epilator.  

Code of Federal Regulations, 2013 CFR

...FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5350 Needle-type epilator. (a) Identification. A...

2013-04-01

343

21 CFR 878.5350 - Needle-type epilator.  

Code of Federal Regulations, 2011 CFR

...FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5350 Needle-type epilator. (a) Identification. A...

2011-04-01

344

21 CFR 878.5350 - Needle-type epilator.  

...FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5350 Needle-type epilator. (a) Identification. A...

2014-04-01

345

House seeks end to needle swaps in District of Columbia.  

PubMed

If the Senate approves a House-passed spending bill that shuts down all needle-exchange programs in the District of Columbia, it may be vetoed by President Clinton. H.R. 4300, an amendment to the District's appropriations bill by Representative Todd Tiahrt, would prohibit any agency receiving Federal funding from operating a needle-exchange program, even if the money for the program comes from private sources. This is the second time this year that the House has officially opposed needle-exchange programs. If the ban becomes law, it could cause many complications by forcing places, such as the Whitman-Walker Clinic, to choose between ending their needle-exchange programs or losing their Federal funding. PMID:11365679

1998-08-21

346

Needle-free drug delivery using shock wave techniques  

E-print Network

A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

Pavlov, Atanas (Atanas Ivanov)

2006-01-01

347

Design of an endoscopic biopsy needle with flexural members  

E-print Network

As a minimally invasive means of extracting a tissue sample from a patient, current endoscopic biopsy needles generally do not preserve tissue histology and often require multiple attempts to obtain a tissue sample. This ...

Figueredo, Stacy L. (Stacy Lee), 1981-

2006-01-01

348

NEEDLE ANATOMY CHANGES WITH INCREASING TREE AGE IN DOUGLAS FIR  

EPA Science Inventory

Morphological differences between old growth and sapling (Pseudotsuga menziesii, (Mirb.) Franco) Douglas fir trees may extend to differences in needle anatomy. We used microscopy with image analysis to compare and quantify anatomical parameters in cross-sections of previous year...

349

The Impact of Re-Using Hypodermic Needles  

Microsoft Academic Search

This paper considers an epidemic which is spread by the re-use of unsterilized hypodermic needles. The model leads to a geometric type distribution with varying success probabilities, which is applied to model the propagation of the Ebola virus.

B. Barnes; J. Gani

350

[Doctor HUANG Shi-ping's acupuncture with golden needles].  

PubMed

Taking Doctor HUANG Shi-ping as the representative, the school of Huang's golden needle is based on Chinese martial art. Golden needles are adopted as main tool. Attaching great importance on the combination of acupuncture and moxibustioin, it is also characterized with penetrating needling with long needles. Through the development of three generations, it once outshone other schools in the field of acupuncture, and became famous all over the world. It made great contribution to the development of the course of acupuncture. However, with the development of the history, the form of acupuncture education as well as apparatus were all undergone an unified reform. Therefore, Doctor HUANG Shi-ping's acupuncture school be lost gradually. PMID:24195225

Chen, Teng-Fei; Ma, Zeng-Bin; Xin, Si-Yuan; Zhu, Jiang

2013-08-01

351

Photoacoustic image-guided needle biopsy of sentinel lymph nodes  

NASA Astrophysics Data System (ADS)

We have implemented a hand-held photoacoustic and ultrasound probe for image-guided needle biopsy using a modified clinical ultrasound array system. Pulsed laser light was delivered via bifurcated optical fiber bundles integrated with the hand-held ultrasound probe. We photoacoustically guided needle insertion into rat sentinel lymph nodes (SLNs) following accumulation of indocyanine green (ICG). Strong photoacoustic image contrast of the needle was achieved. After intradermal injection of ICG in the left forepaw, deeply positioned SLNs (beneath 2-cm thick chicken breast) were easily indentified in vivo and in real time. Further, we confirmed ICG uptake in axillary lymph nodes with in vivo and ex vivo fluorescence imaging. These results demonstrate the clinical potential of this hand-held photoacoustic system for facile identification and needle biopsy of SLNs for cancer staging and metastasis detection in humans.

Kim, Chulhong; Erpelding, Todd N.; Akers, Walter J.; Maslov, Konstantin; Song, Liang; Jankovic, Ladislav; Margenthaler, Julie A.; Achilefu, Samuel; Wang, Lihong V.

2011-03-01

352

24. DETAIL VIEW OF NEEDLE BEAM. NOTE THE WIRE ROPE ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. DETAIL VIEW OF NEEDLE BEAM. NOTE THE WIRE ROPE TIED AROUND THE HANGER CABLE AND THE RAILING POST. March 1987 - Verde River Sheep Bridge, Spanning Verde River (Tonto National Forest), Cave Creek, Maricopa County, AZ

353

Electrochemical Corrosion of STS304 Acupuncture Needles by Electrical Stimulation  

Microsoft Academic Search

We present the first investigation of electrical corrosion in acupuncture needles after electrical stimulation. Using scanning electron microscopy, we observed the occurrence of electrochemical corrosion on the surface of stainless steel 304 acupuncture needles after electrical stimulation in the tibial muscles of rats. Biphasic pulse electrical stimuli with 10-Hz frequency, 1-mA intensity and 1-ms pulse width were applied to the

Hye Suk Hwang; Eun Jin Yang; Yeon Hee Ryu; Myeong Soo Lee; Sun-Mi Choi

2010-01-01

354

Fungal endophytes in seeds and needles of Pinus monticola  

Microsoft Academic Search

Using a sequence-based approach, we investigated the transmission of diverse fungal endophytes in seed and needles of Pinus monticola, western white pine. We isolated 2003 fungal endophytes from 750 surface-sterilized needles. In contrast, only 16 endophytic isolates were obtained from 800 surface-sterilized seeds. The ITS region was sequenced from a representative selection of these endophytes. Isolates were then assigned to

Rebecca J. Ganley; George Newcombe

2006-01-01

355

Microbiologic evaluation of needleless and needle-access devices  

Microsoft Academic Search

Objective: This study was carried out to determine whether needleless intravenous access devices are more likely to allow microorganisms to enter the fluid pathway than intravenous needle-access devices.Methods: A laboratory study was conducted with two needleless and one intravenous needle-access devices and Enterococcus faecium as a bacterial challenge. Inocula of E. faecium were prepared on the basis of the numerical

Matthew J. Arduino; Lee A. Bland; Lisa E. Danzig; Sigrid K. McAllister; Sonia M. Aguero

1997-01-01

356

Targeting error simulator for image-guided prostate needle placement  

Microsoft Academic Search

Motivation: Needle-based biopsy and local therapy of prostate cancer depend multimodal imaging for both target planning and needle guidance. The clinical process involves selection of target locations in a pre-operative image volume and registering these to an intra-operative volume. Registration inaccuracies inevitably lead to targeting error, a major clinical concern. The analysis of targeting error requires a large number of

Andras Lasso; Shachar Avni; Gabor Fichtinger

2010-01-01

357

Deactivation of Escherichia coli by the plasma needle  

Microsoft Academic Search

In this paper we present a parameter study on deactivation of Escherichia coli (E. coli) by means of a non-thermal plasma (plasma needle). The plasma needle is a small-sized (1 mm) atmospheric glow sustained by radio-frequency excitation. This plasma will be used to disinfect heat-sensitive objects; one of the intended applications is in vivo deactivation of dental bacteria: destruction of

R. E. J. Sladek; E. Stoffels

2005-01-01

358

Electrochemical corrosion of STS304 acupuncture needles by electrical stimulation.  

PubMed

We present the first investigation of electrical corrosion in acupuncture needles after electrical stimulation. Using scanning electron microscopy, we observed the occurrence of electrochemical corrosion on the surface of stainless steel 304 acupuncture needles after electrical stimulation in the tibial muscles of rats. Biphasic pulse electrical stimuli with 10-Hz frequency, 1-mA intensity and 1-ms pulse width were applied to the needles. The terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) method labels fragmented DNA. Positive staining using this test indicates apoptotic cells in electrically stimulated tissues. The risk of electrical corrosion was found to be less in bipolar, short-duration, low-current or voltage and short-period stimulation than in monopolar, long-duration, high-current or voltage and long-period stimulation. Evaluation with a scanning electron microscope revealed that electrical stimulation can increase the electrical corrosion of stainless steel 304 acupuncture needles. In biocompatibility studies of stainless steel 304 acupuncture needles for electrical stimulation, TUNEL-positive cells were detected in the tibial muscle within 5 days after electrical stimulation. The results of this study demonstrate that the corrosion products of stainless steel 304 acupuncture needles might affect the post-electrical stimulation tissue response. PMID:20633521

Hwang, Hye Suk; Yang, Eun Jin; Ryu, Yeon Hee; Lee, Myeong Soo; Choi, Sun-Mi

2010-06-01

359

Mechanics of Dynamic Needle Insertion into a Biological Material  

PubMed Central

During needle-based procedures, transitions between tissue layers often lead to rupture events that involve large forces and tissue deformations and produce uncontrollable crack extensions. In this paper, the mechanics of these rupture events is described, and the effect of insertion velocity on needle force, tissue deformation, and needle work is analyzed. Using the J integral method from fracture mechanics, rupture events are modeled as sudden crack extensions that occur when the release rate J of strain energy concentrated at the tip of the crack exceeds the fracture toughness of the material. It is shown that increasing the velocity of needle insertion will reduce the force of the rupture event when it increases the energy release rate. A nonlinear viscoelastic Kelvin model is then used to predict the relationship between the deformation of tissue and the rupture force at different velocities. The model predicts that rupture deformation and work asymptotically approach minimum values as needle velocity increases. Consequently, most of the benefit of using a higher needle velocity can be achieved using a finite velocity that is inversely proportional to the relaxation time of the tissue. Experiments confirm the analytical predictions with multilayered porcine cardiac tissue. PMID:19932986

Mahvash, Mohsen; Dupont, Pierre E.

2010-01-01

360

Neuromuscular Damage and Repair after Dry Needling in Mice  

PubMed Central

Objective. Some dry needling treatments involve repetitive and rapid needle insertions into myofascial trigger points. This type of treatment causes muscle injury and can also damage nerve fibers. The aim of this study is to determine the injury caused by 15 repetitive punctures in the muscle and the intramuscular nerves in healthy mouse muscle and its ulterior regeneration. Methods. We repeatedly needled the levator auris longus muscle of mice, and then the muscles were processed with immunohistochemistry, methylene blue, and electron microscopy techniques. Results. Three hours after the dry needling procedure, the muscle fibers showed some signs of an inflammatory response, which progressed to greater intensity 24?hours after the procedure. Some inflammatory cells could still be seen when the muscle regeneration was almost complete seven days after the treatment. One day after the treatment, some changes in the distribution of receptors could be observed in the denervated postsynaptic component. Reinnervation was complete by the third day after the dry needling procedure. We also saw very fine axonal branches reinnervating all the postsynaptic components and some residual sprouts the same day. Conclusion. Repeated dry needling punctures in muscle do not perturb the different stages of muscle regeneration and reinnervation. PMID:23662122

Domingo, Ares; Mayoral, Orlando; Monterde, Sonia; Santafe, Manel M.

2013-01-01

361

Magnetic resonance imaging of interstitial laser photocoagulation  

NASA Astrophysics Data System (ADS)

We have previously demonstrated the detection of reversible and irreversible changes on MR images oflaser energy deposition and tissue heating and cooling1. It is possible to monitor and control energy deposition during interstitial laser therapy. This presentation describes some first steps toward optimizing the power and total energy deposited in various tissues in vivo, by analyzing the irreversible tissue changes and their spatial distribution as revealed by spin echo imaging. We used various power settings of an Nd.YAG laser delivered by a fiber optic inserted into several tissues (brain, muscle, liver) of anesthetized rats and rabbits. MR imaging was performed at 1.9 T. Photothermally-produced lesions were seen on both T1- and Ta-weighted images. The overall size of the lesions correlated with the magnitude of the energy applied. The MR image appearance depended not only on the laser energy but also on the way it was delivered, on the type of tissue, and the MR pulse sequence applied. While Ti-weighted images adequately demonstrated an area of tissue destruction, T2- weighted images showed a more heterogeneous and more extensive lesion which could be better correlated with the complex histological representation of these lesions. Typically, when rabbit brain, liver, and muscle had been exposed to laser power of 2.5 Watts for a range of 55 to 120 seconds, depending on the tissue, a central area of signal void was surrounded by an inner hypointensity and an outer hyperintensity on T2-weighted images. The 3D extent of the lesions was well demonstrated on multislice images, providing correlation of the affected volumes seen on MRI with volumes seen in histological or histochemical preparations. We are developing an analytical model of laser heating and its effect on MR images to assess whether heating during imaging will produce unacceptable artifacts during surgery. The effect of heating is modeled as a change in magnetization during image acquisition. The region in which the change occurs is blurred by the Fourier transform of the change in magnetization as a function of time. Thus, blurring is minimized when changes occur slowly, compared to image acquisition times. We conclude that MRI can demonstrate the 3D extent of the lesions induced by lasers and can be used to investigate and optimize the control of induced tissue change within the affected volume.

Bleier, Alan R.; Higuchi, Nobuya; Panych, Lawrence P.; Jakab, Peter D.; Hrovat, Mirko I.; Jolesz, Ferenc A.

1990-06-01

362

Heating of industrial sewing machine needles: FEA model and verification using IR radiometry  

NASA Astrophysics Data System (ADS)

With the use of synthetic fabrics and threads in high speed sewing, needle heating due to friction between the needle and the fabric becomes a serious problem which limits further increase of the sewing speed. The high temperature in the needle can accelerate thread wear, cause wear at the needle eye, and damage the thread. It can also scorch the fabric, as well as temper and weaken the needle itself. Experimental methods, such as: infrared radiometry, infrared pyrometry, etc., have been applied to analyze this problem in previous studies. They revealed some important factors that affect the needle peak steady state temperature. In this study the numerical (FEA) model developed to simulate the needle heating is fine tuned and verified via infrared radiometry. The FEA model incorporates detailed needle geometry and the effects of thread on needle heating. It deals with a transient heat transfer process with time and position dependent boundary conditions. It correlates various important factors that affect the needle heating, such as needle characteristics, fabric properties, and sewing conditions to the needle temperature distribution. Given various needle geometries, sewing conditions, and fabric properties, the model can simulate the needle heating process, including the initial heating phase and the steady state. It can also predict the temperature distribution in the needle as well as the time to reach steady state. The trends of the simulation results correlate well with experiments.

Li, Qinwen; Liasi, Evangelos; Simon, Daniel L.; Du, Ruxu; Bujas-Dimitrijevic, Jasmina; Chen, Anshi

1999-03-01

363

High-temperature calcined fullerene nanowhiskers as well as long needle-like multi-wall carbon nanotubes have abilities to induce NLRP3-mediated IL-1? secretion.  

PubMed

Because multi-wall carbon nanotubes (MWCNTs) have asbestos-like shape and size, concerns about their pathogenicity have been raised. Contaminated metals of MWCNTs may also be responsible for their toxicity. In this study, we employed high-temperature calcined fullerene nanowhiskers (HTCFNWs), which are needle-like nanofibers composed of amorphous carbon having similar sizes to MWCNTs but neither metal impurities nor tubular structures, and investigated their ability to induce production a major proinflammatory cytokine IL-1? via the Nod-like receptor pyrin domain containing 3 (NLRP3)-containing flammasome-mediated mechanism. When exposed to THP-1 macrophages, long-HTCFNW exhibited robust IL-1? production as long and needle-like MWCNTs did, but short-HTCFNW caused very small effect. IL-1? release induced by long-HTCFNW as well as by long, needle-like MWCNTs was abolished by a caspase-1 inhibitor or siRNA-knockdown of NLRP3, indicating that NLRP3-inflammasome-mediated IL-1? production by these carbon nanofibers. Our findings indicate that the needle-like shape and length, but neither metal impurities nor tubular structures of MWCNTs were critical to robust NLRP3 activation. PMID:25181346

Cui, Hongyan; Wu, Weijia; Okuhira, Keiichiro; Miyazawa, Kun'ichi; Hattori, Takayuki; Sai, Kimie; Naito, Mikihiko; Suzuki, Kazuhiro; Nishimura, Tetsuji; Sakamoto, Yoshimitsu; Ogata, Akio; Maeno, Tomokazu; Inomata, Akiko; Nakae, Dai; Hirose, Akihiko; Nishimaki-Mogami, Tomoko

2014-09-26

364

Diffusion of He Interstitials and He Clusters in ?-Fe  

SciTech Connect

The accumulation of He atoms in materials will significantly degrade the mechanical properties of materials; therefore, understanding the properties of He interstitials and their clusters in materials is of fundamental importance within a fusion reactor environment. The diffusion properties of single He interstitials and He clusters in the bulk and grain boundaries of ?-Fe are being studied using molecular dynamics with a new Fe?He potential. It is found that the migration barrier for a single He interstitial in the bulk is very low, which is consistent with the result obtained using ab initio methods. Large He clusters can cause Fe self-interstitial atoms (SIA) to be formed, which can be trapped by the resulting vacancy, forming a He-vacancy complex. It is found that for He interstitials in grain boundaries (GBs), the He migration is one-dimensional in a ?11 GB, while it is two-dimensional in a ?3 GB at 600 K and three-dimensional at higher temperatures.

Deng, Huiqiu; Gao, Fei; Heinisch, Howard L.; Kurtz, Richard J.

2011-03-25

365

Role of the interstitial matrix during intestinal volume absorption.  

PubMed

The effects of net volume absorption rate (Jv,m) on intestinal interstitial fluid volume (VI), lymph flow (JL), and the excluded volume fraction for interstitial albumin (FE) were analyzed in an autoperfused cat ileum preparation. Tissue blood volume, extracellular space, and extracellular albumin (VA) were estimated using 51Cr-labeled red blood cells, 99mTc-labeled diethylenetriamine pentaacetic acid (DTPA), and 125I-labeled human serum albumin, respectively. Nonabsorptive values of 27.8 ml/100 g, 18.2 ml/100 g, and 0.37 were acquired for VI, VA, and FE, respectively. Net volume absorption results in an increase in intestinal interstitial volume and lymph flow and decreases the degree of albumin exclusion in the interstitial matrix. The magnitude of the changes in interstitial volume, lymph flow, and excluded volume of albumin during net volume absorption are related to the rate of absorption. The increased matrix hydration during absorption serves to enchance vascular and lymphatic removal of absorbed volume. PMID:7369367

Granger, D N; Mortillaro, N A; Kvietys, P R; Rutili, G; Parker, J C; Taylor, A E

1980-03-01

366

Hermansky-Pudlak syndrome type 4 with interstitial pneumonia  

PubMed Central

Hermansky–Pudlak syndrome (HPS) is an autosomal recessive disorder characterized by oculocutaneous albinism, bleeding tendency, and lysosomal accumulation of ceroid-like material, with occasional development of interstitial pneumonia (IP). Nine genetically distinct subtypes of HPS are known in humans; IP develops primarily in types 1 and 4. Most reported cases of HPS with IP are type 1, and there are no published reports of type 4 in Japanese individuals. A 58-year-old man with congenital oculocutaneous albinism and progressive dyspnea for 1 month was admitted to our hospital. We administered high-dose corticosteroids on the basis of a diagnosis of acute exacerbation of interstitial pneumonia. Respiratory symptoms and the findings of high-resolution computed tomography (CT) showed improvement. He was diagnosed with HPS type 4 with interstitial pneumonia on the basis of gene analysis. He has been receiving pirfenidone for 1 year and his condition is stable. This is the first report on the use of pirfenidone for HPS with IP caused by a novel mutation in the HPS4 gene. We conclude that HPS should be suspected in patients with albinism and interstitial pneumonia. High-dose corticosteroid treatment may be useful in cases of acute exacerbation of interstitial pneumonia due to HPS-4, and pirfenidone may be useful and well tolerated in patients with HPS-4.

Sakata, Yoshihiko; Kawamura, Kodai; Ichikado, Kazuya; Suga, Moritaka; Yoshioka, Masakazu

2013-01-01

367

Rheumatoid Arthritis–associated Interstitial Lung Disease: Radiologic Identification of Usual Interstitial Pneumonia Pattern  

PubMed Central

Purpose To determine the accuracy of computed tomography (CT) in identifying the histopathologic usual interstitial pneumonia (UIP) pattern in rheumatoid arthritis–associated interstitial lung disease (RA-ILD). Materials and Methods All patients were enrolled into institutional review board-approved longitudinal cohorts at their respective institution, and informed consent was obtained at the time of enrollment. Images of patients with surgical lung biopsy-proved RA-ILD (n = 69) were collected from three tertiary care centers. Two experienced thoracic radiologists independently reviewed the CT scans. The CT pattern was categorized as definite UIP, possible UIP, or inconsistent with UIP in accordance with published criteria. Findings of biopsies were reviewed by an experienced lung pathologist. The sensitivity and specificity of definite CT UIP pattern to histopathologic UIP pattern were determined. The agreement between radiologists was assessed by calculating a ? score. Results The histopathologic UIP pattern was present in 42 of 69 (61%) patients. Men were more likely than women to have a histopathologic UIP pattern (P = .02). Twenty patients (29%, 20 of 69) had a definite UIP pattern on CT scans. The specificity of CT UIP pattern was 96% (26 of 27; 95% confidence interval [CI]: 81%, 100%), with a negative predictive value of 53% (26 of 49). The sensitivity of CT UIP pattern was 45% (19 of 42; 95% CI: 30%, 61%), with a positive predictive value of 95% (19 of 20). The agreement between radiologists for definite UIP pattern versus not was 87% (? = 0.67, P < .0001). Conclusion Definite UIP pattern on a CT scan in RA-ILD is highly specific and moderately sensitive for histopathologic UIP pattern. CT can therefore help accurately identify the UIP pattern in RA-ILD. © RSNA, 2013 Online supplemental material is available for this article. PMID:24126367

Assayag, Deborah; Elicker, Brett M.; Urbania, Thomas H.; Colby, Thomas V.; Kang, Bo Hyoung; Ryu, Jay H.; King, Talmadge E.; Collard, Harold R.; Lee, Joyce S.

2014-01-01

368

Comparative study of the skin pathergy test with blunt and sharp needles in Behçet's disease: confirmed specificity but decreased sensitivity with sharp needles  

Microsoft Academic Search

OBJECTIVE--To compare the specificity and sensitivity of the skin pathergy test performed with blunt and sharp needles in patients with Behçet's disease. METHODS--The skin pathergy test was performed using the simultaneous four needle prick method with blunt and sharp, thick and thin needles in 92 patients with Behçet's disease, 64 healthy controls, and 128 patients without Behçet's disease. The test

N Dil?en; M Koniçe; O Aral; L Ocal; M Inanç; A Gül

1993-01-01

369

Successful crizotinib rechallenge after crizotinib-induced interstitial lung disease.  

PubMed

We report the case of a 70-year-old Japanese male diagnosed with advanced lung adenocarcinoma harboring the echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion gene. As soon as crizotinib was administered, tumor shrank immediately. On Day 25, he developed interstitial lung disease. Bronchoalveolar lavage fluid analysis demonstrated elevated lymphocytes fractionation. A drug lymphocyte stimulating test for crizotinib with the bronchoalveolar lavage lymphocytes was negative. Crizotinib administration was discontinued, but a life-threatening flare of tumor growth occurred. Since there was no alternative treatment for the lung cancer, we restarted crizotinib in combination with prednisolone. The patient experienced neither disease progression nor recurrence of interstitial lung disease at 6 months. In cases in which no alternate treatment is known, crizotinib retreatment combined with steroid therapy after crizotinib-induced interstitial lung disease could be considered after a careful consideration of the potential risks and benefits. PMID:24872405

Tachihara, Motoko; Kobayashi, Kazuyuki; Ishikawa, Yumiko; Hori, Suya; Tamura, Daisuke; Otera, Hiroshi; Funada, Yasuhiro; Nishimura, Yoshihiro

2014-08-01

370

Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease  

SciTech Connect

The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later.

Balestra, D.J.; Balestra, S.T.; Wasson, J.H.

1988-07-01

371

Atomic model of the type III secretion system needle.  

PubMed

Pathogenic bacteria using a type III secretion system (T3SS) to manipulate host cells cause many different infections including Shigella dysentery, typhoid fever, enterohaemorrhagic colitis and bubonic plague. An essential part of the T3SS is a hollow needle-like protein filament through which effector proteins are injected into eukaryotic host cells. Currently, the three-dimensional structure of the needle is unknown because it is not amenable to X-ray crystallography and solution NMR, as a result of its inherent non-crystallinity and insolubility. Cryo-electron microscopy combined with crystal or solution NMR subunit structures has recently provided a powerful hybrid approach for studying supramolecular assemblies, resulting in low-resolution and medium-resolution models. However, such approaches cannot deliver atomic details, especially of the crucial subunit-subunit interfaces, because of the limited cryo-electron microscopic resolution obtained in these studies. Here we report an alternative approach combining recombinant wild-type needle production, solid-state NMR, electron microscopy and Rosetta modelling to reveal the supramolecular interfaces and ultimately the complete atomic structure of the Salmonella typhimurium T3SS needle. We show that the 80-residue subunits form a right-handed helical assembly with roughly 11 subunits per two turns, similar to that of the flagellar filament of S. typhimurium. In contrast to established models of the needle in which the amino terminus of the protein subunit was assumed to be ?-helical and positioned inside the needle, our model reveals an extended amino-terminal domain that is positioned on the surface of the needle, while the highly conserved carboxy terminus points towards the lumen. PMID:22699623

Loquet, Antoine; Sgourakis, Nikolaos G; Gupta, Rashmi; Giller, Karin; Riedel, Dietmar; Goosmann, Christian; Griesinger, Christian; Kolbe, Michael; Baker, David; Becker, Stefan; Lange, Adam

2012-06-14

372

Pore formation in a p-type silicon wafer using a platinum needle electrode with application of square-wave potential pulses in HF solution.  

PubMed

By bringing an anodically biased needle electrode into contact with n-type Si at its tip in a solution containing hydrofluoric acid, Si is etched at the interface with the needle electrode and a pore is formed. However, in the case of p-type Si, although pores can be formed, Si is likely to be corroded and covered with a microporous Si layer. This is due to injection of holes from the needle electrode into the bulk of p-type Si, which shifts its potential to a level more positive than the potential needed for corrosion and formation of a microporous Si layer. However, by applying square-wave potential pulses to a Pt needle electrode, these undesirable changes are prevented because holes injected into the bulk of Si during the period of anodic potential are annihilated with electrons injected into Si during the period of cathodic potential. Even under such conditions, holes supplied to the place near the Si/metal interface are used for etching p-type Si, leading to formation of a pore at the place where the Pt needle electrode was in contact. PMID:23347641

Sugita, Tomohiko; Hiramatsu, Kazuki; Ikeda, Shigeru; Matsumura, Michio

2013-02-01

373

From the Cover: Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies  

NASA Astrophysics Data System (ADS)

Arrays of micrometer-scale needles could be used to deliver drugs, proteins, and particles across skin in a minimally invasive manner. We therefore developed microfabrication techniques for silicon, metal, and biodegradable polymer microneedle arrays having solid and hollow bores with tapered and beveled tips and feature sizes from 1 to 1,000 ?m. When solid microneedles were used, skin permeability was increased in vitro by orders of magnitude for macromolecules and particles up to 50 nm in radius. Intracellular delivery of molecules into viable cells was also achieved with high efficiency. Hollow microneedles permitted flow of microliter quantities into skin in vivo, including microinjection of insulin to reduce blood glucose levels in diabetic rats. transdermal drug delivery | skin | microelectromechanical systems | solid microneedle | hollow needle injection

McAllister, Devin V.; Wang, Ping M.; Davis, Shawn P.; Park, Jung-Hwan; Canatella, Paul J.; Allen, Mark G.; Prausnitz, Mark R.

2003-11-01

374

Self-Trapped Interstitial-Type Defects in Iron  

NASA Astrophysics Data System (ADS)

Small interstitial-type defects in iron with complex structures and very low mobilities are revealed by molecular dynamics simulations. The stability of these defect clusters formed by nonparallel ?110? dumbbells is confirmed by density functional theory calculations, and it is shown to increase with increasing temperature due to large vibrational formation entropies. This new family of defects provides an explanation for the low mobility of clusters needed to account for experimental observations of microstructure evolution under irradiation at variance with the fast migration obtained from previous atomistic simulations for conventional self-interstitial clusters.

Terentyev, D. A.; Klaver, T. P. C.; Olsson, P.; Marinica, M.-C.; Willaime, F.; Domain, C.; Malerba, L.

2008-04-01

375

A case of venlafaxine-induced interstitial lung disease.  

PubMed

A patient treated with venlafaxine for major depression developed an interstitial lung disease (ILD) with the characteristic clinical, radiological and pathological features of chronic hypersensitivity pneumonitis. A high resolution computed tomography scan demonstrated ground glass opacity, mosaic perfusion with air-trapping and traction bronchiectasis in both lungs. The pathological findings were consistent with a nonspecific interstitial pneumonia pattern. Clinical and radiological improvements were noted after the discontinuation of venlafaxine and the administration of a corticosteroid. This report provides further evidence that the anti-depressant venlafaxine can cause ILD. PMID:25237379

Oh, Serim; Cha, Seung-Ick; Kim, Hyera; Kim, Minjung; Choi, Sun Ha; Seo, Hyewon; Park, Tae-In

2014-08-01

376

Ectrodactyly and proximal/intermediate interstitial deletion 7q  

SciTech Connect

We report on an individual with severe mental retardation, seizures, microcephaly, unusual face, scoliosis, and cleft feet and cleft right hand. The chromosomal study showed a proximal interstitial deletion 7q (q11.23q22). From our review of the literature, 11 patients have been reported with ectrodactyly (split hand/split foot malformation) and proximal/intermediate interstitial deletions or rearrangements of 7q. The critical segment for ectrodactyly seems to be located between 7q21.2 and 7q22.1. This malformation is present in 41% of the patients whose deletion involves the critical segment. 37 refs., 3 figs., 1 tab.

McElveen, C.; Carvajal, M.V.; Moscatello, D. [Louisiana State Univ. Medical Center, New Orleans, LA (United States)] [and others

1995-03-13

377

Dose and volume specification for reporting interstitial therapy  

SciTech Connect

The ICRU has previously published reports dealing with Dose Specification for Reporting External Beam Therapy with Photons and Electrons (ICRU Report 29, ICRU, 1978), Dose Specification for Reporting External Beam Therapy (ICRU Report 50, ICRU, 1993) and Dose and Volume Specification for Reporting Intracavitary Therapy in Gynecology (ICRU Report 38, ICRU, 1985). The present report addresses the problem of absorbed dose specification for report interstitial therapy. Although specific to interstitial therapy, many of the concepts developed in this report are also applicable to certain other kinds of brachytherapy applications. In particular, special cases of intraluminal brachytherapy and plesio-brachytherapy via surface molds employing x or gamma emitters are addressed in this report.

NONE

1997-12-30

378

Biomonitoring of air quality in the Cologne conurbation using pine needles as a passive sampler—Part I: magnetic properties  

NASA Astrophysics Data System (ADS)

High resolution temporal and spatial control of atmospheric pollutants is of crucial importance for environmental health monitoring. Passive sampling using natural vegetation biomonitoring allows acquisition of well-defined samples at affordable costs. We here present results from a study conducted in the conurbation of Cologne, Germany, based on airborne pollutants accumulated on pine needles. This integrated study includes (i) the microscopic analysis of pine needles and analysis of their magnetic properties, (ii) PAH, and (iii) selected trace elements (Fe, Cd, Pb, Ni, Cr, Cu). A major proportion of atmospheric pollutants is bound to particles, for which in part I of the study we present data on magnetic susceptibility, remanence measurements (IRM, ARM) and total Fe content. SEM-analysis indicates that particles accumulated on needles are mostly <2.5 ?m in diameter and comprise pollen or spores, mineral dust and silica-glassy or metallic spheroids. The latter were identified as magnetite with minor pyrrhotite. These particles derive from combustion of coal in power plants or fuels in vehicular engines. A close correlation of magnetic properties (susceptibility, SIRM, ARM) and Fe content shows that non-destructive, time-efficient enviromagnetics of needles serves as an excellent proxy for biomonitoring of combustion pollutants. Their spatial distribution within the conurbation of Cologne was determined for 43 locations integrated in a GIS-database. The dominant sources of fine metallic particulates (PM 2.5) are emissions from road traffic, including fuel combustion, corrosion and brake-wear and from railroad and tram traffic preferentially due to material wear. Parks, forests and agricultural areas show the lowest levels of pollution by magnetic particles, followed by residential areas. This implies that traffic emissions with short transportation distances (<1.0 km) are dominant in the Cologne conurbation, whereas the contribution from power plants is negligible.

Urbat, M.; Lehndorff, E.; Schwark, L.

379

Dependence of needle architecture and chemical composition on canopy light availability in three North American Pinus species with contrasting needle length.  

PubMed

Morphology and chemical composition of needles of shade-intolerant southern conifers (Pinus palustris Mill. (mean needle length +/- SD = 29.1 +/- 4.1 cm), P. taeda L. (12.3 +/- 2.9 cm) and P. virginiana Mill. (5.1 +/- 0.8 cm)) were studied to test the hypothesis that foliage acclimation potential to canopy light gradients is generally low for shade-intolerant species, and in particular, because of mechanical limitations, in species with longer needles. Plasticity for each needle variable was defined as the slope of the foliar characteristic versus irradiance relationship. A novel geometrical model for needle area and volume calculation was employed for the three-needled species P. palustris and P. taeda. Needle thickness (T) strongly increased, but width (W) was less variable with increasing daily integrated quantum flux density averaged over the season (Q(int)), resulting in changes in cross-sectional needle shape that were manifested in a positive relationship between the total to projected needle area ratio (A(T)/A(P)) and Q(int) in the three-needled species. In contrast, cross-sectional needle geometry was only slightly modified by irradiance in the two-needled conifer P. virginiana. Needle dry mass per unit total needle area (M(T)) was positively related to Q(int) in all species, leading to greater foliar nitrogen contents per unit area at higher irradiances. Separate examination of the components of M(T) (density (D) and the volume (V) to A(T) ratio; M(T) = DV/A(T)) indicated that the positive effect of light on M(T) resulted solely from increases in V/A(T), i.e., from increases in the thickness of foliage elements. Foliar chlorophyll content per unit mass increased with increasing Q(int), allowing an improvement in light-harvesting efficiency in low light. The variables characterizing needle material properties (D, the dry to fresh mass ratio, and needle carbon content per unit mass) were generally independent of Q(int), suggesting that needles were less stiff and had greater tip deflections under their own weight at lower irradiances because of smaller W and T. Comparisons with the literature revealed that plasticity in foliar characteristics tended to be lower in the studied shade- intolerant species than in shade-tolerant conifers, but plasticity among the investigated species was unaffected by needle length. However, we argue that, because of mechanical limitations, plastic changes in needle cross section in response to low irradiance may decrease rather than increase light-interception efficiency in long-needled species. PMID:12184979

Niinemets, Ulo; Ellsworth, David S; Lukjanova, Aljona; Tobias, Mari

2002-08-01

380

Prestress as an optimal biomechanical parameter for needle penetration.  

PubMed

Drug delivery requires precise intradermal and subcutaneous injections of formulations to clinically relevant penetration depths. However, penetration depth is confounded by skin deflection, which occurs prior to and during penetration as the skin surface deforms axially with the needle, and which varies profoundly due to differing intrinsic mechanical (e.g. viscoelastic) tissue properties, disease state, aging, and ethnicity. Herein, an ex vivo model was utilized to study factors that affect skin deflection and the efficacy of injection, including prestress applied at the tissue surface, needle gauge, velocity, and actuation depth. The application of prestress minimized skin deflection during needle penetration and allowed for needle actuation to the targeted penetration depths with minimum variability. The force required to achieve target penetration depths was found to increase with prestress and decrease with needle gauge. Our findings emphasize the need for prestress applied to the skin surface to minimize variation in skin properties and administer formulations for intradermal and subcutaneous treatments with maximum precision. PMID:22381739

Butz, Kent D; Griebel, Adam J; Novak, Tyler; Harris, Kevin; Kornokovich, Amy; Chiappetta, Michael F; Neu, Corey P

2012-04-30

381

Fungal endophytes in seeds and needles of Pinus monticola.  

PubMed

Using a sequence-based approach, we investigated the transmission of diverse fungal endophytes in seed and needles of Pinus monticola, western white pine. We isolated 2003 fungal endophytes from 750 surface-sterilized needles. In contrast, only 16 endophytic isolates were obtained from 800 surface-sterilized seeds. The ITS region was sequenced from a representative selection of these endophytes. Isolates were then assigned to the most closely related taxa in GenBank. Although 95% of the endophytes in needles from mature trees belonged to the Rhytismataceae, 82 unique ITS sequences were obtained from at least 21 genera and 10 different orders of fungi. Significantly, none of the endophytes in seed were rhytismataceous (chi(2) = 180; P < 0.001). Similarly, needles of greenhouse seedlings yielded only non-rhytismataceous isolates, whereas seedlings of the same age that had naturally regenerated near older white pines in roadless areas were colonized by rhytismataceous endophytes almost to the same extent as in mature trees. Only one of 17 rhytismataceous isolates were able to grow on a medium containing only 0.17% nitrogen, whereas 25 of 31 non-rhytismataceous endophytes grew. Rhytismataceous endophytes are dominant in needles of P. monticola, but they appear to be absent in seed, and unlikely colonists of nitrogen-limiting host tissues such as the apoplast. PMID:16492396

Ganley, Rebecca J; Newcombe, George

2006-03-01

382

An allelopathic substance in red pine needles (Pinus densiflora).  

PubMed

Aqueous methanol extracts of red pine (Pinus densiflora) needles inhibited the growth of roots and shoots of cress (Lepidium sativum), lettuce (Lactuca sativa), alfalfa (Medicago sativa), ryegrass (Lolium multiflorum), timothy (Pheleum pratense), Digitaria sanguinalis and Echinochloa crus-galli. Increasing the extract concentration increased inhibition, suggesting that the pine needles may have growth inhibitory substances and possess allelopathic potential. The aqueous methanol extract of the pine needles was purified, and a main inhibitory substance was isolated and determined by spectral data as 9alpha,13beta-epidioxyabeit-8(14)en-18-oic acid. This substance inhibited root and shoot growth of cress and Echinochloa crus-galli seedlings at concentrations greater than 0.1 mM. The endogenous concentration of the substance was 0.13 mmol/kg pine needle. These results suggest that 9alpha,13beta-epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory effect of the pine needles and may play an important role in the allelopathy of red pine. PMID:18755523

Kato-Noguchi, Hisashi; Fushimi, Yoshiko; Shigemori, Hideyuki

2009-03-01

383

[Study on needling Ying method for treatment of sore throat].  

PubMed

To explore the mechanism of needling Ying method for treatment of sore throat. By the analysis of pathogenesis of sore throat, the authors think the key of its pathogenesis is stagnation of pathogenic factors such as hotness and phlegm accumulating, and meridian-vessel obstruction in the throat is its meridian foundation. There are several meridians passing through the throat, so the throat is closely related to viscera and meridians, and stagnation of pathogenic factors such as hotness and phlegm accumulating in the throat lead to sore throat when exogenous pathogenic factors invading or dysfunction of viscera and meridians. The treatment of needling Ying at local throat or combined with corresponding meridian point selection can dredge collaterals, dispel pathogenic factors, remove pathogenic factors to dispel swelling, resolve phlegm and dissipate stagnation and harmonize yin and yang, so as to relieve sore throat. In conclusion, needling Ying method is an important method in the treatment of sore throat. PMID:19873925

Xie, Qiang; He, Xing-wei; Huang, Bing-lin; Tao, Bo

2009-10-01

384

[Dupuytren's contracture: percutaneous needle aponeurotomy is an alternative to surgery].  

PubMed

Dupuytren's contracture is a retractile fibrosis of the superficial palmar aponeurosis of the hand, resulting in a progressive and fixed flexion of the fingers that may result in severe limitation of hand function. It affects several millions of people in Europe and North America. Risk factors are genetic and sometimes related to mellitus diabetes. There is no spontaneous remission. Until recently, surgery was the only treatment, but now needle aponeurotomy emerges as a therapeutic alternative. It should be performed as first line treatment by a trained practitioner. Short and long-term results of needle aponeurotomy appear identical to those of surgery, with milder complications. It is indicated in palmar, palmo-digital, as well as in strictly digital forms of the disorder. The "table-test" is used to assess the loss of extension of the digit and to select the indication to needle aponeurotomy. A medico-surgical consensus should define the optimum treatment strategy in this affection. PMID:20828892

Manet, M-P; Roulot, E; Teyssedou, J-P; Lahalle, S; Ziza, J-M

2011-04-01

385

Subcutaneous tumor seeding following needle core biopsy of hepatocellular carcinoma.  

PubMed

Hepatocellular carcinoma (HCC) is the most common primary hepatic tumor and one of the most common cancers worldwide. At present, there are two widely used and accepted methods for obtaining diagnostic material for establishing the likelihood of malignancy in a hepatic mass, namely fine-needle aspiration (FNA) cytology and needle core biopsy (NCB). In recent years, however, tumor cell seeding along the needle tract has been shown to be a risk associated with using these procedures to obtain a pathologic diagnosis. We report a case of a patient who presented with a nodule in the anterior abdominal wall at the expected location of the previous NCB tract. FNA biopsy of the abdominal wall lesion confirmed the presence of malignant cells consistent with HCC. The finding of tumor seeding within a NCB tract raises the question of the role of NCB in the diagnostic workup of focal liver lesions. PMID:17924404

Rowe, Leslie R; Mulvihill, Sean J; Emerson, Lyska; Gopez, Evelyn V

2007-11-01

386

Connective Tissue Disease-associated Interstitial Lung Disease: A review  

PubMed Central

Interstitial lung disease (ILD) is commonly encountered in patients with connective tissue diseases (CTD). Besides the lung parenchyma, the airways, pulmonary vasculature and structures of the chest wall may all be involved, depending on the type of CTD. As a result of this so-called multi-compartment involvement, airflow limitation, pulmonary hypertension, vasculitis and extrapulmonary restriction can occur alongside fibro-inflammatory parenchymal abnormalities in CTD. Rheumatoid arthritis (RA), systemic sclerosis (SSc), poly-/dermatomyositis (PM/DM), Sjögren’s syndrome (SjS), systemic lupus erythematosus (SLE), and undifferentiated (UCTD) as well as mixed connective tissue disease (MCTD) can all be associated with the development of ILD. Non-specific interstitial pneumonia (NSIP) is the most commonly observed histopathological pattern in CTD-ILD, but other patterns including usual interstitial pneumonia (UIP), organizing pneumonia (OP), diffuse alveolar damage (DAD) and lymphocytic interstitial pneumonia (LIP) may occur. Although the majority of patients with CTD-ILD experience stable or slowly advancing ILD, a small yet significant group exhibits a more severe and progressive course. Randomized placebo-controlled trials evaluating the efficacy of immunomodulatory treatments have been conducted only in SSc-associated ILD. However, clinical experience suggests that a handful of immunosuppressive medications are potentially effective in a sizeable portion of patients with ILD caused by other CTDs. In this manuscript, we review the clinical characteristics and management of the most common CTD-ILDs. PMID:23125954

Gutsche, Markus; Rosen, Glenn D.; Swigris, Jeffrey J.

2012-01-01

387

Interstitial water chemistry of the Santa Barbara Basin sediments  

Microsoft Academic Search

The interstitial water composition (SO 4 2- , alkalinity, sulfide, Ca 2+ , Mg 2+ , K + , Si(OH) 4 , phosphate, NO 2 - , NO 3 - , NH 4 + , and Cl%.) of both the `basin' sediment in the center of the Santa Barbara Basin and the `slope' sediment shallower than the basin sill is

Edward Sholkovitz

1973-01-01

388

Lupus nephritis: Correlation of interstitial cells with glomerular function  

Microsoft Academic Search

Lupus nephritis: Correlation of interstitial cells with glomerular function. Mononuclear inflammatory cells were studied using monoclonal antibodies in the interstitium and glomeruli of 35 renal biopsy specimens from patients with lupus nephritis already taking immunosuppressants. The aims of this study were to assess the composition and significance of the infiltrate, and to assess correlations with immediate glomerular function and ability

Efstathios Alexopoulos; Daniel Seron; R Barrie Hartley; J Stewart Cameron

1990-01-01

389

Near-infrared fiber delivery systems for interstitial photothermal therapy  

NASA Astrophysics Data System (ADS)

Interstitial photothermal coagulation has long been recognized as a potential important, minimally invasive modality for treating a variety of pathologic conditions. We present two different technologies for interstitial photothermal coagulation of tissue with infrared lasers: An optical fiber with a radially symmetric diffusing tip for deep coagulation, and a flat bare fiber for the coagulation of thin and long lesions by longitudinally moving the fiber while lasing in concert. Urology and Gynecology Fibers: The fibers are 600 microns diameter with 20 - 40 mm frosted distal tips protected by a smooth transparent cover. When used with a Neodymium:YAG (Nd:YAG) laser, the active fiber surface diffuses optical radiation in a radial pattern, delivering up to 40 W power, and thus providing consistent and uniform interstitial photothermal therapy. Coagulation depth ranges from 4 to 15 mm. Animal studies in the United States and clinical studies in Europe have demonstrated the feasibility of using these fibers to treat benign prostatic hyperplasia and endometrial coagulation. Rhinology Fiber: The fiber is an 800 micron diameter flat fiber operated at 8 W power level while being interstitially pushed and pulled along its axis. A long and thin coagulated zone is produced. The fiber is routinely used for the shrinking of hypertrophic turbinates without surrounding and bone mucusal damage in ambulatory environments.

Slatkine, Michael; Mead, Douglass S.; Konwitz, Eli; Rosenberg, Zvi

1995-05-01

390

Arthritis and interstitial granulomatous dermatitis (Ackerman syndrome) with pulmonary silicosis  

Microsoft Academic Search

Objective: To describe the case of a patient suffering from pulmonary silicosis associated with a rheumatoid factor negative, antinuclear antibody positive, symmetrical, nonerosive synovitis, and interstitial granulomatous dermatitis (IGD) and compare it with similar cases reported in the literature. Methods: Literature search to identify published cases of IGD with arthritis and cases associated with silicosis. Results: Thiry-eight cases of IGD

Stephan Kroesen; Peter H. Itin; Paul Hasler

2003-01-01

391

Helium self-interstitial atom interaction in ?-iron  

NASA Astrophysics Data System (ADS)

The effect of He impurities on the properties and behavior of self-interstitial atom (SIA) clusters in ?-Fe has been simulated by atomistic molecular dynamics (MD) and molecular statics (MS) simulation techniques using semi-empirical interatomic potentials and compared to ab initio electronic structure calculations. The MD simulations reveal many interactions between He and SIA clusters, including a spontaneous SIA-substitutional He recombination and replacement mechanism that ejects He into interstitial positions and a strong interaction between He, in either interstitial or substitutional positions, with SIA and SIA clusters and also with other He atoms. The MS calculations reveal relatively small interaction trapping radii of about 1 nm between interstitial He and SIA cluster complexes, but strong binding energies from 1.3 to 4.4 eV, depending on cluster size and interaction geometry. The comparisons between the ab initio and semi-empirical interactions are in generally good agreement and indicate that the He-point defect interactions in bcc Fe are well represented by considering the displacement (strain) field interactions amongst the defects.

Ventelon, Lisa; Wirth, Brian; Domain, Christophe

2006-06-01

392

Image based diagnostic aid system for interstitial lung diseases  

Microsoft Academic Search

Automatic classification of lung tissue patterns in high-resolution computed tomography (HRCT) images of patients affected with interstitial lung diseases (ILD) is an important stage in the construction of a computer-aided diagnosis system. In this study, we propose a new image based system for classification of lung tissue patterns. The proposed system comprises three stages. In the first stage, the parenchyma

Azar Tolouee; Hamid Abrishami Moghaddam; Mohamad Forouzanfar; Masoumeh Gity; Rahil Garnavi

2011-01-01

393

Multifrequency ultrasound transducers for conformal interstitial thermal therapy  

Microsoft Academic Search

Control over the pattern of thermal damage generated by interstitial ultrasound heating applicators can be enhanced by changing the ultrasound frequency during heating. The ability to change transmission frequency from a single transducer through the use of high impedance front layers was investigated in this study. The transmission spectrum of multifrequency transducers was calculated using the KLM equivalent circuit model

Rajiv Chopra; C. Luginbuhl; F. Stuart Foster; Michael J. Bronskill

2003-01-01

394

Origin of Interstitial Cells of Cajal in the Mouse Intestine  

Microsoft Academic Search

The interstitial cells of Cajal (ICC) are found in a number of different locations in the gastrointestinal tract, where they form close associations with both muscle cells and nerve terminals. In this study we examined the embryological origin of ICC in the mouse intestine to determine whether they arise from the neural crest or from the intestinal wall. Segments of

H. M. Young; D. Ciampoli; B. R. Southwell; D. F. Newgreen

1996-01-01

395

Paraelastic interstitials in molybdenum (*) (**) B. Beuneu and Y. Qur  

E-print Network

of resistivity Apo = 245 nO. cm corresponding to a Frenkel pair concentration of about 1.9 x 10-4 [5. 2014 The paraelastic relaxation of a point defect of interstitial nature has been observed between 22) and the energy (72 ± 3 meV) of this relaxation have been measured. The resistivity of the defect is higher when

Paris-Sud XI, Université de

396

Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease  

Microsoft Academic Search

The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar

D. J. Balestra; S. T. Balestra; J. H. Wasson

1988-01-01

397

Iodine 125 interstitial irradiation for localized prostate cancer.  

PubMed Central

We present the technique, complications, and 5-year results of transperineal percutaneous template permanent interstitial iodine 125 endocurietherapy of localized prostate cancer in 85 treated patients. The 5-year outcome appears similar to that of external beam radiation therapy or radical surgery, but the iatrogenic mortality, morbidity, treatment time, and hospitalization are significantly reduced. Images Figure 1 Figure 2 Figure 3 PMID:2319613

Kumar, P. P.; Good, R. R.; Bartone, F. F.

1990-01-01

398

High Interstitial Fluid Pressure Is Associated with Low Tumour Penetration of Diagnostic Monoclonal Antibodies Applied for Molecular Imaging Purposes  

PubMed Central

The human epithelial cell adhesion molecule (EpCAM) is highly expressed in a variety of clinical tumour entities. Although an antibody against EpCAM has successfully been used as an adjuvant therapy in colon cancer, this therapy has never gained wide-spread use. We have therefore investigated the possibilities and limitations for EpCAM as possible molecular imaging target using a panel of preclinical cancer models. Twelve human cancer cell lines representing six tumour entities were tested for their EpCAM expression by qPCR, flow cytometry analysis and immunocytochemistry. In addition, EpCAM expression was analyzed in vivo in xenograft models for tumours derived from these cells. Except for melanoma, all cell lines expressed EpCAM mRNA and protein when grown in vitro. Although they exhibited different mRNA levels, all cell lines showed similar EpCAM protein levels upon detection with monoclonal antibodies. When grown in vivo, the EpCAM expression was unaffected compared to in vitro except for the pancreatic carcinoma cell line 5072 which lost its EpCAM expression in vivo. Intravenously applied radio-labelled anti EpCAM MOC31 antibody was enriched in HT29 primary tumour xenografts indicating that EpCAM binding sites are accessible in vivo. However, bound antibody could only be immunohistochemically detected in the vicinity of perfused blood vessels. Investigation of the fine structure of the HT29 tumour blood vessels showed that they were immature and prone for higher fluid flux into the interstitial space. Consistent with this hypothesis, a higher interstitial fluid pressure of about 12 mbar was measured in the HT29 primary tumour via “wick-in-needle” technique which could explain the limited diffusion of the antibody into the tumour observed by immunohistochemistry. PMID:22590529

Heine, Markus; Freund, Barbara; Nielsen, Peter; Jung, Caroline; Reimer, Rudolph; Hohenberg, Heinrich; Zangemeister-Wittke, Uwe; Wester, Hans-Juergen; Luers, Georg H.; Schumacher, Udo

2012-01-01

399

Scattering by single ice needles and plates at 30 GHz  

NASA Technical Reports Server (NTRS)

Because of the small loss tangent of ice at 30-50 GHz, significant depolarization of satellite-to-ground communication signals could occur due to the presence of cirrus clouds in their paths. It is known that cirrus clouds basically consist of ice needles and plates. Extensive calculations have been performed for the problem of scattering by a family of ice needles and plates for various length-to-width ratios ranging from 1 to 10. Scattering results with special attention to induced cross-polarized fields will be presented.

Yeh, C.; Woo, R.; Armstrong, J.; Ishimaru, A.

1982-01-01

400

[Pleural needle biopsy in diagnosis of pleural effusion].  

PubMed

Diagnostic reliability of percutaneous parietal pleural biopsy with use of the Abrams needle technique performed over a period 1989-1994 was assessed in 37 patients with pleural effusion of unknown etiology, aged 24-82 years. Adequate diagnostic specimens were obtained in 33 patients. Histopathological diagnosis established neoplasma (39,4%), tuberculosis (9.1%) and chronic nonspecific pleuritis (51,5%). No complications of the procedure were encountered. Pleural needle biopsy should be more widely applied as a basic method in the diagnosis of pleural effusions of unknown etiology. PMID:8630469

Fija?kowski, M; B?och, P; Kulig, A; Graczyk, J; Szmidt, M

1996-01-01

401

Microdefects and self-interstitial diffusion in crystalline silicon  

SciTech Connect

In this thesis, a study is presented of D-defects and self-interstitial diffusion in silicon using Li ion (Li{sup +}) drifting in an electric field and transmission electron microscopy (TEM). Obstruction of Li{sup +} drifting has been found in wafers from certain but not all FZ p-type Si. Incomplete Li{sup +} drifting always occurs in the central region of the wafers. This work established that interstitial oxygen is not responsible for hindering Li{sup +} drifting. TEM was performed on a samples from the partially Li{sup +} drifted area and compared to regions without D-defects. Precipitates were found only in the region containing D-defects that had partially Li{sup +} drifted. This result indicates D-defects are responsible for the precipitation that halts the Li{sup +} drift process. Nitrogen (N) doping has been shown to eliminate D-defects as measured by conventional techniques. Li{sup +} drifting and D-defects provide a useful means to study Si self-interstitial diffusion. The process modeling program SUPREM-IV was used to simulate the results of Si self-interstitial diffusion obtained from Li{sup +} drifting experiments. Anomalous results from the Si self-interstitial diffusion experiments forced a re-examination of the possibility of thermal dissociation of D-defects. Thermal annealing experiments that were performed support this possibility. A review of the current literature illustrates the need for more research on the effects of thermal processing on FZ Si to understand the dissolution kinetics of D-defects.

Knowlton, W.B.

1998-05-01

402

Alternative to surgery of treatment of unruptured interstitial pregnancy: 15 cases of medical treatment  

Microsoft Academic Search

Objective: To evaluate medical treatment of interstitial pregnancy. Methods: This series was a retrospective study of medical treatment of interstitial pregnancies which was managed in two French Departments of Obstetrics and Gynecology (Bichat public Hospital, Paris and A. Béclère public Hospital, Clamart, France). Fifteen patients with clear evidence of an unruptured interstitial pregnancy were treated by injection of methotrexate (MTX)

Jean-Louis Benifla; Hervé Fernandez; Eric Sebban; Emile Darai; René Frydman; Patrick Madelenat

1996-01-01

403

Analysis of Blood Glucose Concentration by Interstitial Fluid Extracted in a Minimally Invasive way  

Microsoft Academic Search

A novel minimally invasive way to measure blood glucose concentration is proposed by combining interstitial fluid (ISF) transdermal extraction and surface plasmon resonance (SPR) detection. 55 kHz low-frequency ultrasound pulses are applied for 30 seconds to enhance the skin permeability and then interstitial fluid is extracted out of skin by vacuum. The glucose concentration in the interstitial fluid is determined

Xiaotang Hu; Kexin Xu; Xuejun Cao; Xinghua Qu; Dachao Li

2009-01-01

404

Interstitial fluid flow: simulation of mechanical environment of cells in the interosseous membrane  

NASA Astrophysics Data System (ADS)

In vitro experiments have shown that subtle fluid flow environment plays a significant role in living biological tissues, while there is no in vivo practical dynamical measurement of the interstitial fluid flow velocity. On the basis of a new finding that capillaries and collagen fibrils in the interosseous membrane form a parallel array, we set up a porous media model simulating the flow field with FLUENT software, studied the shear stress on interstitial cells' surface due to the interstitial fluid flow, and analyzed the effect of flow on protein space distribution around the cells. The numerical simulation results show that the parallel nature of capillaries could lead to directional interstitial fluid flow in the direction of capillaries. Interstitial fluid flow would induce shear stress on the membrane of interstitial cells, up to 30 Pa or so, which reaches or exceeds the threshold values of cells' biological response observed in vitro. Interstitial fluid flow would induce nonuniform spacial distribution of secretion protein of mast cells. Shear tress on cells could be affected by capillary parameters such as the distance between the adjacent capillaries, blood pressure and the permeability coefficient of capillary's wall. The interstitial pressure and the interstitial porosity could also affect the shear stress on cells. In conclusion, numerical simulation provides an effective way for in vivo dynamic interstitial velocity research, helps to set up the vivid subtle interstitial flow environment of cells, and is beneficial to understanding the physiological functions of interstitial fluid flow.

Yao, Wei; Ding, Guang-Hong

2011-08-01

405

Prognostic Implications of Physiologic and Radiographic Changes in Idiopathic Interstitial Pneumonia  

Microsoft Academic Search

Idiopathic interstitial pneumonias are a diverse group of lung dis- eases with varied prognoses. We hypothesized that changes in physiologic and radiographic parameters would predict survival. We retrospectively examined 80 patients with usual interstitial pneumonia and 29 patients with nonspecific interstitial pneumonia. Baseline characteristics were examined together with 6-month change in forced vital capacity, diffusing capacity for carbon monox- ide,

Kevin R. Flaherty; Jeanette A. Mumford; Susan Murray; Ella A. Kazerooni; Barry H. Gross; Thomas V. Colby; William D. Travis; Andrew Flint; Galen B. Toews; Joseph P. Lynch; Fernando J. Martinez

2003-01-01

406

Lymphatic fluctuation in the parenchymal remodeling stage of acute interstitial pneumonia, organizing pneumonia, nonspecific interstitial pneumonia and idiopathic pulmonary fibrosis  

PubMed Central

Because the superficial lymphatics in the lungs are distributed in the subpleural, interlobular and peribroncovascular interstitium, lymphatic impairment may occur in the lungs of patients with idiopathic interstitial pneumonias (IIPs) and increase their severity. We investigated the distribution of lymphatics in different remodeling stages of IIPs by immunohistochemistry using the D2-40 antibody. Pulmonary tissue was obtained from 69 patients with acute interstitial pneumonia/diffuse alveolar damage (AIP/DAD, N = 24), cryptogenic organizing pneumonia/organizing pneumonia (COP/OP, N = 6), nonspecific interstitial pneumonia (NSIP/NSIP, N = 20), and idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP, N = 19). D2-40+ lymphatic in the lesions was quantitatively determined and associated with remodeling stage score. We observed an increase in the D2-40+ percent from DAD (6.66 ± 1.11) to UIP (23.45 ± 5.24, P = 0.008) with the advanced process of remodeling stage of the lesions. Kaplan-Meier survival curves showed a better survival for patients with higher lymphatic D2-40+ expression than 9.3%. Lymphatic impairment occurs in the lungs of IIPs and its severity increases according to remodeling stage. The results suggest that disruption of the superficial lymphatics may impair alveolar clearance, delay organ repair and cause severe disease progress mainly in patients with AIP/DAD. Therefore, lymphatic distribution may serve as a surrogate marker for the identification of patients at greatest risk for death due to IIPs. PMID:22488224

Parra, E.R.; Araujo, C.A.L.; Lombardi, J.G.; Ab'Saber, A.M.; Carvalho, C.R.R.; Kairalla, R.A.; Capelozzi, V.L.

2012-01-01

407

A Lorentz-force actuated controllable needle-free drug delivery system  

E-print Network

The advantages of delivering injections via needle-free methods are numerous. However, conventional methods for needle-free injection lack sufficient control over depth of penetration and shape of injection. Thus, a ...

Hemond, Brian D. (Brian David Thomson)

2004-01-01

408

A shield ring enhanced equilateral hexagon distributed multi-needle electrospinning spinneret  

E-print Network

The multi-needle electrospinning system is a convenient way to produce fibers with special structures such as core-shell morphologies at a high production rate. In this paper, a specially designed multi-needle electrospinning ...

Zahn, Markus

409

Experimental analysis of stove top designs for pine needle combustion in a semi-gasifier burner  

E-print Network

The motivation behind this project was to develop a better understanding of the role that the stove top plays in a stove where pine needles are the main fuel source. Pine needles have distinct characteristics in their ...

Roqué, Alyssa J

2011-01-01

410

Characteristics of pine needle combustion in a semi-gasifier burner  

E-print Network

The motivation behind this report was to develop a stronger understanding of pine needle combustion behavior in a semi-gasifier, in order to ultimately design an effective pine needle cook stove for people in the developing ...

Fang, Liane Jessica

2011-01-01

411

In vivo motion and force measurement of surgical needle intervention during prostate brachytherapy  

Microsoft Academic Search

In this paper, we present needle insertion forces and motion trajectories measured during actual brachytherapy needle insertion while implanting radioactive seeds in the prostate glands of 20 different patients. The needle motion was captured using ultrasound images and a 6 degree-of-freedom electromagnetic-based position sensor. Needle velocity was computed from the position information and the corresponding time stamps. From in vivo

Tarun Podder; Douglas Clark; Jason Sherman; Dave Fuller; Edward Messing; Deborah Rubens; John Strang; Ralph Brasacchio; Lydia Liao; Wan-Sing Ng; Yu Yan

2006-01-01

412

First-principles study of He point-defects in HCP rare-earth metals  

SciTech Connect

He defect properties in Sc, Y, Gd, Tb, Dy, Ho, Er and Lu were studied using first-principles calculations based on density functional theory. The results indicate that the formation energy of an interstitial He atom is smaller than that of a substitutional He atom in all hcp rare-earth metals considered. Furthermore, the tetrahedral interstitial position is more favorable than an octahedral position for He defects. The results are compared with those from bcc and fcc metals.

Li, Yang; Chen, Ru; Peng, SM; Long, XG; Wu, Z.; Gao, Fei; Zu, Xiaotao

2011-05-01

413

Chronic effect of cadmium in sediments on colonization by benthic marine organisms: An evaluation of the role of interstitial cadmium and acid-volatile sulfide in biological availability  

SciTech Connect

The role of interstitial cadmium and acid-volatile sulfide (AVS) in controlling the bioavailability of sediment-associated metal was examined using the chronic saltwater benthic colonization test. Sediments were spiked to achieve nominal cadmium/AVS molar ratios of 0.0 (control), 0.1, 0.8, and 3.0 in this 118-d test. Oxidation of AVS in the surficial 2.4 cm within 2 to 4 weeks resulted in sulfide profiles similar to those occurring naturally in local sediments. In the nominal 0.1 cadmium/AVS treatment measured simultaneously extracted metal (SEM{sub Cd}) was always less than AVS. Interstitial cadmium concentrations were less than those likely to cause biological effects. No significant biological effects were detected. In the nominal 0.8 cadmium/AVS treatment, measured SEM{sub Cd} commonly exceeded AVS in the surficial 2.4 cm of sediment. Interstitial cadmium concentrations were of likely toxicological significance to highly sensitive species. Shifts in the presence or absence over all taxa, and fewer macrobenthic polychaetes (Mediomastus ambiseta, Streblospio benedicti, and Podarke obscurea) and unidentified meiofaunal nematodes, were observed. In the nominal 3.0 cadmium/AVS treatment, concentrations of SEM{sub Cd} were always greater than AVS throughout the sediment column. Interstitial cadmium ranged from 28,000 to 174,000 {micro}g/L. In addition to the effects above, the sediments were colonized by fewer macrobenthic species, polychaete species, and harpacticoids; had lower densities of diatoms; lacked bivalve molluscs; and exhibited other impacts. Over all treatments, the observed biological responses were consistent with SEM{sub Cd}/AVS ratios in surficial sediments and interstitial water cadmium concentrations.

Hansen, D.J.; Berry, W.J.; Benyi, S.J. [Environmental Protection Agency, Narragansett, RI (United States); Mahony, J.D. [Manhattan Coll., New York, NY (United States). Dept. of Environmental Engineering; Corbin, J.M. [Texas Natural Resource Conservation Commission, Austin, TX (United States). Environmental Assessment Div.; Pratt, S.D. [Univ. of Rhode Island, Narragansett, RI (United States). Graduate School of Oceanography; Toro, D.M. di [Manhattan Coll., New York, NY (United States). Dept. of Environmental Engineering]|[HydroQual, Inc., Mahwah, NJ (United States); Abel, M.B. [Univ. of Rhode Island, Kingston, RI (United States). Botany Dept.

1996-12-01

414

Influence of electrode geometry on liquid metal ion source performance  

Microsoft Academic Search

The surface electric field distribution along the axis of a wetted needle type liquid metal ion source has been determined by numerical methods and is shown to exhibit a secondary maximum at the intersection of the cylindrical and conical sections. It is shown that the volume flow rate of the liquid metal film along the cylindrical portion of the emitter

L. W. Swanson; J. Z. Li

1988-01-01

415

COMPUTERIZED BREAST CANCER DIAGNOSIS AND PROGNOSIS FROM FINE NEEDLE ASPIRATES  

E-print Network

1 COMPUTERIZED BREAST CANCER DIAGNOSIS AND PROGNOSIS FROM FINE NEEDLE ASPIRATES William H. Wolberg in size or character. Patients with cancer received standard treatment. #12; 4 Outcome Measures: Cross methods based on linear programming that were applicable to breast cancer diagnosis and prognostic

Street, Nick

416

Technical procedures and staining methods for renal needle biopsies.  

PubMed

Procedures specifically developed for kidney needle biopsies are presented. These procedures may be applied to improve the slide quality of all small specimens. Fixation, processing, knife sharpening, cutting, and staining procedures used by the author are discussed. A modification of the Jones method for basement membranes is given. PMID:59547

Sugulas, M

1976-06-01

417

MRI image overlay: Application to arthrography needle insertion  

Microsoft Academic Search

Magnetic Resonance Imaging (MRI) provides great potential for planning, guiding, monitoring and controlling interventions. MR arthrography (MRAr) is the imaging gold standard to assess small ligament and fibrocartilage injury in joints. In contemporary prac- tice, MRAr consists of two consecutive sessions: 1) an interven- tional session where a needle is driven to the joint space and MR contrast is injected

Gregory S. Fischer; Anton Deguet; Csaba Csoma; Russell H. Taylor; Laura Fayad; John A. Carrino; S. James Zinreich; Gabor Fichtinger

2007-01-01

418

MRI Image Overlay: Applications to Arthrography Needle Insertion  

Microsoft Academic Search

Magnetic Resonance Imaging (MRI) has unmatched potential for planning, guid- ing, monitoring and controlling interventions. MR arthrography (MRA) is the imaging gold standard to assess small ligament and fibrocartilage injury in joints. In contemporary practice, MRA consists of two consecutive sessions: 1) an inter- ventional session where a needle is driven to the joint space and gadolinium con- trast is

Gregory S. Fischer; Anton Deguet; Daniel Schlattman; Russell Taylor; Laura Fayad; S. James Zinreich; Gabor Fichtinger

2006-01-01

419

Segmentation of prostate biopsy needles in transrectal ultrasound images  

NASA Astrophysics Data System (ADS)

Prostate cancer is the most common cancer in men. Tissue extraction at different locations (biopsy) is the gold-standard for diagnosis of prostate cancer. These biopsies are commonly guided by transrectal ultrasound imaging (TRUS). Exact location of the extracted tissue within the gland is desired for more specific diagnosis and provides better therapy planning. While the orientation and the position of the needle within clinical TRUS image are limited, the appearing length and visibility of the needle varies strongly. Marker lines are present and tissue inhomogeneities and deflection artefacts may appear. Simple intensity, gradient oder edge-detecting based segmentation methods fail. Therefore a multivariate statistical classificator is implemented. The independent feature model is built by supervised learning using a set of manually segmented needles. The feature space is spanned by common binary object features as size and eccentricity as well as imaging-system dependent features like distance and orientation relative to the marker line. The object extraction is done by multi-step binarization of the region of interest. The ROI is automatically determined at the beginning of the segmentation and marker lines are removed from the images. The segmentation itself is realized by scale-invariant classification using maximum likelihood estimation and Mahalanobis distance as discriminator. The technique presented here could be successfully applied in 94% of 1835 TRUS images from 30 tissue extractions. It provides a robust method for biopsy needle localization in clinical prostate biopsy TRUS images.

Krefting, Dagmar; Haupt, Barbara; Tolxdorff, Thomas; Kempkensteffen, Carsten; Miller, Kurt

2007-03-01

420

Sharps legislation and assessment of needle protection systems.  

PubMed

Needlestick injuries (NSIs) carry the potential for transmission of serious blood-borne infections and pose a significant risk to patients and healthcare staff. These infections come with an estimated cost of £300 million per year in the UK (Saia et al, 2010). An EU directive mandated in May of 2013 has sought to minimise the risk of NSI though the introduction of needle-protection systems. The authors of this article set out to assess nursing knowledge of this legislation and ascertain which needle-protection systems for low-molecular weight heparin/anti Xa (for subcutaneous administration) were preferred in a large teaching trust. Approximately half of the nurses questioned had some knowledge of the legislation and almost all agreed that there is a need for needle protection systems. All four devices tested meet requirements for the legislation but the preferred devices were the needle protection system for enoxaparin and fondaparinux with a self-sheathing style device after activation. PMID:24464057

Wright, Paul; Caughey, Gary; Antoniou, Sotiris

421

Clinton said to be serious about vetoing ban on needles.  

PubMed

Congress is ready to pass an appropriations bill barring the District of Columbia from using its own funds for needle-exchange programs. The Clinton administration appears ready to veto, if the bill passes. D.C. representative, Eleanor Holmes Norton, is asking that the bill be voted down when Congress returns in September. PMID:11366911

1999-09-01

422

Randomized interventions for needle procedures in children with cancer.  

PubMed

The aim of this study was to examine whether children experience less fear, distress and pain connected to a routine needle insertion in an intravenous port when subjected to an intervention: blowing soap bubbles or having a heated pillow vs. standard care. Twenty-eight children, 2-7 years, cared for at a paediatric oncology unit, undergoing a routine needle insertion in an intravenous port were included consecutively. All children were subjected to two needle insertions; at the first they received standard care, and at the second standard care + a randomized intervention. Parents and nurses assessed children's fear, distress and pain on 0-100 mm visual analogue scales. According to parents' report, children experienced less fear when subjected to intervention vs. standard care reported by parents (P < 0.001). Children also experienced less fear (P < 0.05) and distress (P < 0.05) when subjected to standard care + blowing soap bubbles vs. standard care (n = 14), and less fear when subjected to standard care + heated pillow vs. standard care (P < 0.05). Nurses' reports did not show any differences for standard care + intervention vs. standard care. Blowing soap bubbles or having a heated pillow is more effective than standard care in reducing children's fear and distress in needle procedures, according to parents' report. PMID:19040458

Hedén, L; VON Essen, L; Ljungman, G

2009-07-01

423

Depression among needle exchange program and methadone maintenance clients  

Microsoft Academic Search

The objective of this study was to compare the prevalence of major depression in two cohorts of injection drug users, those enrolled in a Rhode Island Methadone Maintenance Treatment Program (MMTP) and those enrolled in a Rhode Island Needle Exchange Program (NEP) using cross-sectional interviews. Symptomatic and duration criteria for major depression in the last 6 months were identified using

Rebecca S. Brienza; Michael D. Stein; Mei-Hsiu Chen; Aruna Gogineni; Mindy Sobota; Jina Maksad; Ping Hu; Jennifer Clarke

2000-01-01

424

Sensorless Motion Planning for Medical Needle Insertion in Deformable Tissue  

E-print Network

for the success of these procedures. However, significant errors are common in current practice. For brachytherapy1 Sensorless Motion Planning for Medical Needle Insertion in Deformable Tissue Ron Alterovitz, Ken Goldberg, Fellow, IEEE, Jean Pouliot, I-Chow Hsu Abstract--Minimally invasive medical procedures

O'Brien, James F.

425

The Single Needle Lockstitch Machine. [Sewing Seams.] Module 4.  

ERIC Educational Resources Information Center

This module on sewing seams, one in a series on the single needle lockstitch sewing machine for student self-study, contains three sections. Each section includes the following parts: an introduction, directions, an objective, learning activities, student information, student self-check, check-out activities, and an instructor's final checklist.…

South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

426

Mathematics in the Needle Trades. Computing Piecework. Module 2.  

ERIC Educational Resources Information Center

This module on computing piecework, one in a series on the needle trades, contains the following components: an introduction, directions, an objective, learning activities, student information, student self-check, check-out activities, and an instructor's final checklist. The module presents information on the piecework pay plan, such as…

South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

427

The Single Needle Lockstitch Machine. [Constructing Darts.] Module 3.  

ERIC Educational Resources Information Center

This module on constructing darts, one in a series on the single needle lockstitch sewing machine for student self-study, contains two sections. Each section includes the following parts: an introduction, directions, an objective, learning activities, student information, student self-check, check-out activities, and an instructor's final…

South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

428

The Single Needle Lockstitch Machine. [Setting a Collar.] Module 5.  

ERIC Educational Resources Information Center

This module on sewing collars, one in a series on the single needle lockstitch sewing machine for student self-study, contains three sections. Each section includes the following parts: an introduction, directions, an objective, learning activities, student information, student self-check, check-out activities, and an instructor's final checklist.…

South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

429

Silicon Micro-Needles with Flexible Interconnections , Y. Hanein1  

E-print Network

with rugged and dynamic tissues. Prototype devices were tested for usability and animal- compatibility diomedea show full recovery from surgery and implantation, and survive up to a minimum of fourteen days behaving animals. Our technique allows the integration of rigid silicon needles with polyimide (PI

430

[Renal needle biopsy under echography. Apropos of 413 examinations].  

PubMed

Blindly executed for a long period with only X-ray detection, renal biopsy benefits nowadays of precision and security of real-time echoguiding. The authors describe their technique without bondage between needle and transducer and comment their results about 413 examinations. PMID:2131183

Desrentes, M; Eynard, J P; Konde, L; Ba, A A; Morcillo, J L; Favre, Y

1990-01-01

431

Injection Techniques Locations and Needle Choice Max Irsik DVM, MAB  

E-print Network

, anthelmentics, analgesics and vitamins. Giving injections properly improves animal welfare, product response in the area lameness and a compromise to the immune response. The two main muscles located in the injectionInjection Techniques Locations and Needle Choice Max Irsik DVM, MAB Beef Cattle Extension

Watson, Craig A.

432

26. VIEW SHOWING NEEDLE VALVE TRASH RACK NEARING COMPLETION. ARCHES ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

26. VIEW SHOWING NEEDLE VALVE TRASH RACK NEARING COMPLETION. ARCHES VISIBLE IN THIS PICTURE ARE 8, 9, 10, AND 11, WHICH HAVE BEEN COMPLETED TO SPRINGING LINE ELEVATIONS 1700, 1744, 1766 AND 1766 RESPECTIVELY. January 1, 1939 - Bartlett Dam, Verde River, Phoenix, Maricopa County, AZ

433

Electrical equivalence of electrospray ionization with conducting and nonconducting needles.  

PubMed

An electrical equivalent circuit is derived for the electrospray process. It is a series circuit which consists of the power supply, the electrochemical contact to the solution, the solution resistance (R(s)), a constant-current regulator which represents the processes of charge separation and charge transport in the gap between the spray needle aperture and the counter electrode, and charge neutralization at the counter electrode. A current i, established by the constant-current regulator flows throughout the entire circuit. Current-voltage curves are developed for each element in the circuit. From these it is shown that in the case where R(s) is negligible (the power supply is connected directly to a conducting needle) the shape of the current-voltage curve is dictated by the constant-current regulator established by the charge separation process, the gap, and the counter electrode. The solution resistance may be significant if a nonconducting needle is used so that the electrochemical contact to the solution is remote from the tip. Experiments with a nonconducting spray needle quantify the effect of the solution resistance on the current-voltage curve. Subtracting the iRs voltage from Vapp (power supply voltage) yields the current-voltage curve for the constant-current regulator. When iRs drop is a significant fraction of Vapp, the current-voltage curve of the constant-current regulator is changed substantially from the case when the solution resistance is negligible. PMID:10489527

Jackson, G S; Enke, C G

1999-09-01

434

finding a needle in a Facebook's photo storage  

E-print Network

finding a needle in a Haystack Facebook's photo storage presented by: Angelos Sakellaropoulos system A characterization of the requests made to Facebook's photo sharing app. #12;NFS based Storage, files stored as: /hay/haystack_ID> very few i-nodes (physical files) per Store Machine

Karp, Brad

435

Micron size GMR magnetic sensor with needle structure  

NASA Astrophysics Data System (ADS)

The work presents inimitable shaped needle type probe with spin valve giant magnetoresistance (SV-GMR) elements. Sensitive elements with 75 ?m width are connected in the Wheatstone bridge structure. The length of the needle is 20-30 mm and its cross section is square. The magnetic sensor probe has the advantage of micron order spatial resolution. The needle type probe works as a gradient meter which concurrently suppresses the influence of externally applied field and detects magnetic fields emanating from nano or micro order size sources. Sensing elements present high sensitivity 260 ?V/?T and are capable of detecting the magnetic fields in order of few nT. SV-GMR elements present flat amplitude and phase characteristics in wide frequency range. The novel characteristicsof the probe allow it to be utilized in detection of the in-phase and out of phase signal components. An additional merit of this design is extremely small liftoff height between sensing element and the source of magnetic field. The SV-GMR elements are isolated only by very thin protection layer (a few ?m), that gives opportunity to apply the probe in biological (in vivo) experiments, and in non destructive evaluation of current detection. The needle shape allows the sensing element toapproach the examined materials in a distance of few ten ?m.

Yamada, S.; Haraszczuk, R.; Kakikawa, M.; Hoang, H.

2012-05-01

436

A Computer Based Simulator for Ultrasound Guided Needle Insertion Procedures  

Microsoft Academic Search

A system for the simulation of needle insertion procedures under ultrasound guidance is presented. This is a core skill in interventional radiology, currently acquired on an apprenticeship basis. The system is designed to improve the early stages of training, and detect people with poor natural ability. The simulator is based on a volumetric data set which is non-rigidly aligned to

D. Magee; D. Kessel

437

The effects of diesel injector needle motion on spray structure.  

SciTech Connect

The internal structure of diesel fuel injectors is known to have a significant impact on the steady-state fuel distribution within the spray. However, little experimental or computational work has been performed on the dynamics of fuel injectors. Recent studies have shown that it is possible to measure the three-dimensional geometry of the injector nozzle, and to track changes in that geometry as the needle opens and closes in real time. This has enabled the dynamics of the injector to be compared with the dynamics of the spray, and allows computational fluid dynamics (CFD) simulations to use realistic time-dependent flow passage geometries. In this study, X-ray phase-enhanced imaging has been used to perform time-resolved imaging of the needle seat area in several common-rail diesel injection nozzles. The fuel distributions of the sprays emitted by these injectors were also studied with fast X-ray radiography. Correlations between eccentric motions of the injector needle valve and oscillations in the fuel density as it emerges from the nozzle are examined. CFD modeling is used to interpret the effect of needle motion on fuel flow.

Powell, C. F.; Kastengren, A. L.; Liu, Z.; Fezzaa, K. (Energy Systems); ( XSD)

2011-01-01

438

Efficacy of needle biopsy in postradiation thyroid disease  

Microsoft Academic Search

Retrospective review was carried out of 124 patients with nodular disease of the thyroid gland and a history of radiation exposure who had undergone needle aspiration biopsy. Latency period from time of radiation varied from 2 to 50 years; but in 92 patients it exceeded 2 decades. Our patient group included those with occupational exposure and a past history of

I. B. Rosen; J. A. Palmer; J. Bain; H. Strawbridge; P. G. Walfish

1983-01-01

439

A case of juvenile Sjögren's syndrome with interstitial nephritis.  

PubMed

Primary Sjögren's syndrome (SS) is a rare autoimmune disease, especially in children. Juvenile primary SS with interstitial nephritis is rare in Japan. We report on a 12-year-old girl in whom salivary gland swelling had recurred from the age of 5 years, SS was diagnosed at the age of 10 years, and interstitial nephritis developed at the age of 12 years. The patient presented with a chief complaint of swelling of both parotid glands. The patient had a history of recurrent parotitis from 5 years of age, with episodes recurring 5 to 6 times a year and resolving within 3 days each time. However, at the age of 11 years, the patient had continuous mild swelling of the parotid glands. Examination on admission showed bilateral nontender parotid gland swelling; mild swelling of the lower extremities, xerostomia, and xerophthalmia but no exanthem. Laboratory findings were as follows: serum protein, 10.1 g/dL; immunoglobulin (Ig) G, 3,828 mg/dL; antinuclear antibodies, 1,280-fold; anti-Ro/SS-A antibody, 512-fold; anti-Ro/SS-B antibody, 4-fold; creatinine, 0.45 mg/dL; blood ?2-microglobulin, 2.2 mg/L (slightly elevated); and cystatin C, 0.86 mg/L. Urinalysis showed proteinuria and a ?2-microglobulin concentration of 11,265 mg/L. Thus, this patient had low molecular weight proteinuria. Schirmer's test showed decreased tear secretion (5 mm), and fluorescein staining showed marked bilateral superficial punctate keratitis. A lip biopsy showed infiltration by small round cells (mild to moderate), interstitial fibrosis, loss of salivary gland parenchyma, and atrophy, with no obvious epimyoepithelial islands, leading to a diagnosis of SS. Light microscopic examination of the renal biopsy specimens showed expansion of mononuclear cell infiltration in the renal interstitium, inflammatory cell infiltration of interstitial areas with edema and mild fibrosis, and tubulitis and mononuclear cell infiltration that included many lymphocytes and plasma cells. There were no pathological findings of glomerulonephritis. Small arteries showed no obvious abnormalities. Immunofluorescent staining showed slight, nonspecific deposition of IgM, but no deposition of IgG, complement 1q, 3, or 4. On the basis of the renal biopsy showing nonspecific chronic interstitial nephritis, renal tubular atrophy, and interstitial enlargement, tubulointerstitial nephritis associated with SS was diagnosed. PMID:22976609

Igarashi, Toru; Itoh, Yasuhiko; Shimizu, Akira; Igarashi, Tsutomu; Yoshizaki, Kaoru; Fukunaga, Yoshitaka

2012-01-01

440

Site occupancy of interstitial deuterium atoms in face-centred cubic iron  

NASA Astrophysics Data System (ADS)

Hydrogen composition and occupation state provide basic information for understanding various properties of the metal–hydrogen system, ranging from microscopic properties such as hydrogen diffusion to macroscopic properties such as phase stability. Here the deuterization process of face-centred cubic Fe to form solid-solution face-centred cubic FeDx is investigated using in situ neutron diffraction at high temperature and pressure. In a completely deuterized specimen at 988?K and 6.3?GPa, deuterium atoms occupy octahedral and tetrahedral interstitial sites with an occupancy of 0.532(9) and 0.056(5), respectively, giving a deuterium composition x of 0.64(1). During deuterization, the metal lattice expands approximately linearly with deuterium composition at a rate of 2.21?Å3 per deuterium atom. The minor occupation of the tetrahedral site is thermally driven by the intersite movement of deuterium atoms along the ‹111› direction in the face-centred cubic metal lattice.

Machida, Akihiko; Saitoh, Hiroyuki; Sugimoto, Hidehiko; Hattori, Takanori; Sano-Furukawa, Asami; Endo, Naruki; Katayama, Yoshinori; Iizuka, Riko; Sato, Toyoto; Matsuo, Motoaki; Orimo, Shin-Ichi; Aoki, Katsutoshi

2014-09-01

441

Site occupancy of interstitial deuterium atoms in face-centred cubic iron  

PubMed Central

Hydrogen composition and occupation state provide basic information for understanding various properties of the metal–hydrogen system, ranging from microscopic properties such as hydrogen diffusion to macroscopic properties such as phase stability. Here the deuterization process of face-centred cubic Fe to form solid-solution face-centred cubic FeDx is investigated using in situ neutron diffraction at high temperature and pressure. In a completely deuterized specimen at 988?K and 6.3?GPa, deuterium atoms occupy octahedral and tetrahedral interstitial sites with an occupancy of 0.532(9) and 0.056(5), respectively, giving a deuterium composition x of 0.64(1). During deuterization, the metal lattice expands approximately linearly with deuterium composition at a rate of 2.21?Å3 per deuterium atom. The minor occupation of the tetrahedral site is thermally driven by the intersite movement of deuterium atoms along the ‹111› direction in the face-centred cubic metal lattice. PMID:25256789

Machida, Akihiko; Saitoh, Hiroyuki; Sugimoto, Hidehiko; Hattori, Takanori; Sano-Furukawa, Asami; Endo, Naruki; Katayama, Yoshinori; Iizuka, Riko; Sato, Toyoto; Matsuo, Motoaki; Orimo, Shin-ichi; Aoki, Katsutoshi

2014-01-01

442

Site occupancy of interstitial deuterium atoms in face-centred cubic iron.  

PubMed

Hydrogen composition and occupation state provide basic information for understanding various properties of the metal-hydrogen system, ranging from microscopic properties such as hydrogen diffusion to macroscopic properties such as phase stability. Here the deuterization process of face-centred cubic Fe to form solid-solution face-centred cubic FeDx is investigated using in situ neutron diffraction at high temperature and pressure. In a completely deuterized specimen at 988?K and 6.3?GPa, deuterium atoms occupy octahedral and tetrahedral interstitial sites with an occupancy of 0.532(9) and 0.056(5), respectively, giving a deuterium composition x of 0.64(1). During deuterization, the metal lattice expands approximately linearly with deuterium composition at a rate of 2.21?Å(3) per deuterium atom. The minor occupation of the tetrahedral site is thermally driven by the intersite movement of deuterium atoms along the ‹111› direction in the face-centred cubic metal lattice. PMID:25256789

Machida, Akihiko; Saitoh, Hiroyuki; Sugimoto, Hidehiko; Hattori, Takanori; Sano-Furukawa, Asami; Endo, Naruki; Katayama, Yoshinori; Iizuka, Riko; Sato, Toyoto; Matsuo, Motoaki; Orimo, Shin-Ichi; Aoki, Katsutoshi

2014-01-01

443

41 CFR 109-27.5009 - Control of hypodermic needles and syringes.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Control of hypodermic needles and syringes. 109-27.5009 Section...109-27.5009 Control of hypodermic needles and syringes. Effective procedures...management and physical security of hypodermic needles and syringes to prevent illegal use....

2010-07-01

444

Needle and seed segmentation in intra-operative 3D ultrasound-guided prostate brachytherapy.  

PubMed

In order to guide the needle to the correct location in 3D US-guided brachytherapy, the needle is continuously tracked as it is being inserted. A pre-scan before the needle insertion and a post-scan after the needle insertion are subtracted to obtain a difference image containing the needle. The image is projected along two orthogonal directions approximately perpendicular to the needle, and the 3D needle is reconstructed from the segmented needles in the two projected images. The seeds implanted with the needle are located in the cropped volume along the needle. Thus, the seeds are segmented using a tri-bar model and 3D line segment patterns. Finally, the positions of the seeds are determined using a peak detection technique. Experiments with agar and turkey/chicken phantoms as well as patient data demonstrated that our needle segmentation technique could segment the needle in near real-time with an accuracy of 0.6 mm in position and 1.0 degrees in orientation. The true-positive rate for seed segmentation is 100% for the agar phantom and 93% for the chicken phantom. The average distance to manual seed segmentation was 1.0mm for the agar phantom and 1.7 mm for the chicken phantom. PMID:16908040

Ding, Mingyue; Wei, Zhouping; Gardi, Lori; Downey, Donal B; Fenster, Aaron

2006-12-22

445

Needle Steering in Biological Tissue using Ultrasound-based Online Curvature Estimation  

E-print Network

are commonly per- formed for diagnostic and therapeutic purposes. Accurate placement of the needle tip. The average targeting error using our new adaptive method is 40% lower than using the conventional non-adaptive duty-cycled needle steering method. I. INTRODUCTION Needle insertion in soft tissues is a common step

North Carolina at Chapel Hill, University of

446

Fast Needle Insertion to Minimize Tissue Deformation and Damage Mohsen Mahvash and Pierre E. Dupont  

E-print Network

the analytical predictions. I. INTRODUCTION Medical needle interventions are a common technique for accessing of the ventricle [9]. It is commonly known that faster motions of a sharp tool or needle cause less tissue in less needle insertion position error. The model predicts that tissue deformation and absorbed energy

Dupont, Pierre

447

A systematic approach to fabricate high aspect ratio silicon micro-needles for transdermal drug delivery  

NASA Astrophysics Data System (ADS)

The successful development of micro-needles can help transport drugs and vaccines both effectively and painlessly across the skin. However, not all micro-needles are strong enough to withstand the insertion forces and viscoelasticity of the skin. The work here focuses on the micro-fabrication of high aspect ratio needles with careful control of needle-profile using dry etching technologies. Silicon micro-needles, 150?m in length with base-diameters ranging from 90 to 240?m have been investigated in this study. A novel, multiple-sacrificial approach has been demonstrated as suited to the fabrication of long micro-needle bodies with positive profiles. The parameters that control the isotropic etching are adjusted to control the ratio of the needle-base diameter to needle length. By careful control of geometry, the needle profile can be engineered to give a suitable tip size for penetration, as well as a broad needle base to facilitate the creation of either single or multiple-through holes. This approach allows the mechanical properties of the otherwise brittle needles to be optimized. Finite element analysis indicates that the micro-needles will fracture prematurely due to buckling, with forces ranging from 10 to 30mN.

Ng, H. B.; Shearwood, C.

2007-12-01

448

Development and evaluation of optical needle depth sensor for percutaneous diagnosis and therapies  

NASA Astrophysics Data System (ADS)

Current methods of needle insertion during percutaneous CT and MRI guided procedures lack precision in needle depth sensing. The depth of the needle insertion is currently monitored through depth markers drawn on the needle and later confirmed by intra-procedural imaging; until this confirmation, the physicians' judgment that the target is reached is solely based on the depth markers, which are not always clearly visible. We have therefore designed an optical sensing device which provides continuous feedback of needle insertion depth and degree of rotation throughout insertion. An optical mouse sensor was used in conjunction with a microcontroller board, Arduino Due, to acquire needle position information. The device is designed to be attached to a needle guidance robot developed for MRI-guided prostate biopsy in order to aid the manual insertion. An LCD screen and three LEDs were employed with the Arduino Due to form a hand-held device displaying needle depth and rotation. Accuracy of the device was tested to evaluate the impact of insertion speed and rotation. Unlike single dimensional needle depth sensing developed by other researchers, this two dimensional sensing device can also detect the rotation around the needle axis. The combination of depth and rotation sensing would be greatly beneficial for the needle steering approaches that require both depth and rotation information. Our preliminary results indicate that this sensing device can be useful in detecting needle motion when using an appropriate speed and range of motion.

Palmer, Keryn; Alelyunas, David; McCann, Connor; Yoshimitsu, Kitaro; Kato, Takahisa; Song, Sang-Eun; Hata, Nobuhiko

2014-03-01

449

Assessment of Vibrotactile Feedback in a Needle-Insertion Task using a Surgical Robot  

E-print Network

-loading on the simulated tissue pad and prevented needle rotation in the needle driver. The forces exerted by the needle trauma to tissues and muscles surrounding the diseased organs in a minimally-invasive surgery, thereby reducing complications and post-surgery recovery time. However, much debate exists on what role, if any

Tan, Hong Z.

450

Dielectric Barrier Discharges in Helium at Atmospheric Pressure: Experiments and Model in the Needle-Plane Geometry  

NASA Astrophysics Data System (ADS)

We present an experimental and theoretical modeling study of "dielectric barrier discharges" (DBD) at atmospheric pressure in a needle-plane configuration. Synchronous, Ultra High Speed Imaging (UHSI, using a Princeton Instruments PI-MAX 512RB Digital ICCD Camera System) and real-time dual detection (optical-electrical) diagnostics have been carried out in a flow of He. A phase-resolved synchronizing circuit was used to trigger the ICCD camera's shutter for durations varying from 2 ns up to 100 ms. All diagnostics, including the PI-MAX images, could be precisely synchronized and processed on a PC computer. The high voltage electrode was a steel needle with a sharp point of precisely-machined radius, while a thin (1.6 mm) ceramic (Al2O3) plate with a metallized bottom surface was used as the ground electrode. Three different situations have been studied, namely (i) the bare Al2O3, and with an ultra-thin coatings of (ii) graphite (a semiconductor) or (iii) metal, the latter two at floating potential. The purpose of these experiments was to investigate possible effects of surface charging on the discharge behavior [1]. The axial [y(t)] and radial [x(t)] time evolutions of the discharge have been measured by UHSI, plotted, and found to differ very significantly among cases (i) to (iii). In the needle-plane configuration (like in the plane-plane case), the DBD is characterized by a single pulse per half-period of the applied voltage. A two-dimensional model of the needle-plane discharge, based upon the continuity equations for electrons, ions, excited particles, and the Poisson equation, is developed; it assumes a low degree of ionization, so that the transport coefficients of the gas are uniquely determined by the local electric field [2]. In order to determine the electric field and the electrical potential in the (hyperboloidal) needle-plane geometry, the finite element method is used. We have found excellent agreement between measured and calculated [y(t)] and [x(t)] data, indicating that surface charge density and -distribution greatly influence the discharge events while they evolve across the gap space. [1] Nikonov V., Bartnikas R., and Wertheimer M.R., IEEE Trans. Plasma Sci. 29 (2001) 866. [2] Novak J.P., and Bartnikas R., J. Appl. Phys. 62 (1987) 3605.

Radu, Ion; Bartnikas, Raymond; Wertheimer, Michael

2002-10-01

451

New real time needle segmentation technique using grayscale Hough transformation  

NASA Astrophysics Data System (ADS)

Real-time needle segmentation and tracking is very important in image-guided surgery, biopsy, and therapy. In this paper, we described an automated technique to provide real-time needle segmentation from a sequence of 2-D ultrasound images for the use of guidance of a needle to the target in soft tissues. The Hough transform is used to find straight lines or analytic curves in binary image. Hough transform is applied usually to binary images. Hence one needs to convert, initially, the gray level image to a binary one (through thresholding, edge detection, or thinning) in order to apply the HT. While in the process of binarization, some information about line segments in the image may be lost when an inappropriate threshold is used. Gray-Scale Hough Transform can detect the line without binarization. Unfortunately, its high computational cost often prevents it from being applied in real-time applications without the help of specially designed hardware. In this paper, we proposed a needle segmentation technique based on a real-time gray-scale Hough transform. It is composed of an improved Gray Hough Transformation and a coarse-fine search strategy. Furthermore, the RTGHT (Real-Time Gray-Scale Hough Transform) technique is evaluated by patient breast biopsy images. Experiments with patient breast biopsy ultrasound (US) image sequences showed that our approach can segment the biopsy needle in real time (i.e., less than 60 ms) with the angular rms error of about 1° and the position rms error of about 0.5 mm an affordable PC computer without the help of specially designed hardware.

Qiu, Wu; Zhou, Hua; Ding, Mingyue; Zhang, Songgeng

2007-12-01

452

Lung Cancer and Interstitial Lung Diseases: A Systematic Review  

PubMed Central

Interstitial lung diseases (ILDs) represent a heterogeneous group of more than two hundred diseases of either known or unknown etiology with different pathogenesis and prognosis. Lung cancer, which is the major cause of cancer death in the developed countries, is mainly attributed to cigarette smoking and exposure to inhaled carcinogens. Different studies suggest a link between ILDs and lung cancer, through different pathogenetic mechanisms, such as inflammation, coagulation, dysregulated apoptosis, focal hypoxia, activation, and accumulation of myofibroblasts as well as extracellular matrix accumulation. This paper reviews current evidence on the association between lung cancer and interstitial lung diseases such as idiopathic pulmonary fibrosis, sarcoidosis, systemic sclerosis, dermatomyositis/polymyositis, rheumatoid arthritis, systemic lupus erythematosus, and pneumoconiosis. PMID:22900168

Archontogeorgis, Kostas; Steiropoulos, Paschalis; Tzouvelekis, Argyris; Nena, Evangelia; Bouros, Demosthenes

2012-01-01

453

Interstitially implanted I125 for prostate cancer using transrectal ultrasound  

SciTech Connect

Prostate cancer is the third leading cause of death from cancer among men in the United States. Traditional treatments for prostate cancer are prostatectomy, external beam irradiation, and interstitial implantation of Iodine125 (I125) via laparotomy. These treatments are associated with significant morbidity and limitations. Based on experience with I125 interstitial implantation by transrectal ultrasound guidance for early-stage prostate cancer, it seems that this newer method of treatment has greater accuracy of placement and distribution of the isotope and has had few reported complications. The need for a surgical incision has been eliminated. Hospitalization time also has been decreased, creating the need for ambulatory and inpatient nurses to understand the importance of their respective roles in providing coordinated quality care for these patients. Nurses in these departments must have knowledge of the procedure, radiation safety, and common side effects related to the implant.

Greenburg, S.; Petersen, J.; Hansen-Peters, I.; Baylinson, W. (Northwest Tumor Institute, Seattle, WA (USA))

1990-11-01

454

Carbamazepine-induced interstitial pneumonitis associated with pan-hypogammaglobulinemia  

PubMed Central

Carbamazepine remains a first-line drug for treatment of epilepsy in children. A wide variety of side effects have been attributed to its use, including a mild involvement of the immune system, usually a transient decline in IgA. Pulmonary complications, including interstitial pneumonitis, were mainly described in adults, and are considered rare side effects. In this report we describe the first pediatric patient who developed a severe interstitial pneumonitis and a pan-hypogammaglobulinemia 2 months after starting carbamazepine. A gradual resolution of symptoms and complete immune recovery was observed after the drug withdrawal, but 6 months later our patient still has a marked reduction in lung volumes and decreased exercise tolerance. We suggest that immunoglobulins should be carefully examined after carbamazepine initiation, particularly if the patient develops any sign of immunosuppression.

Goncalves, Daniel; Moura, Rute; Ferraz, Catarina; Vitor, Artur Bonito; Vaz, Luisa

2012-01-01

455

Interstitial granulomatous dermatitis and arthritis revealing oesophageal carcinoma.  

PubMed

Interstitial granulomatous dermatitis and arthritis (IGDA) is an uncommon clinicopathological condition that may occur in association with a number of systemic disorders. We present a novel case of IGDA in association with oesophageal squamous cell carcinoma (SCC). A 67-year-old man with a 3-month history of arthritis presented with several erythematous indurated plaques on his lateral trunk and arms. An oesophagogastroduodenoscopy showed an irregular mass 20 mm in size in the proximal third of the oesophagus, and on histopathological examination of a biopsy, the mass was identified as a poorly differentiated SCC. Histopathological examination of a skin biopsy found features consistent with interstitial granulomatous dermatitis. The combination of clinicopathological correlation and laboratory findings led to the diagnosis of IGDA. This association has not been previously described, to our knowledge. PMID:23777491

Moyano Almagro, B; López Navarro, N; Contreras Steyls, M; Gallego Dominguez, E; Herrera Acosta, E; Herrera Ceballos, E

2013-07-01

456

[Interstitial granulomatous dermatitis without arthritis: successful therapy with hydroxychloroquine].  

PubMed

Interstitial granulomatous dermatitis is a rare entity characterized by cutaneous linear strands (the "rope sign") and rheumatoid arthritis. In the past years, 12 other cases have been described with variable cutaneous symptoms. All showed similar histological features, resembling those of granuloma annulare or 'palisaded neutrophilic and granulomatous dermatitis', suggesting a wide spectrum for a single entity. A 60-year-old patient presented with erythematous patches with an indurated, violaceous border resembling the "rope sign" on both flanks. The histological investigation revealed dense diffuse interstitial inflammatory infiltrates composed of eosinophils, neutrophils, lymphocytes, macrophages and multinucleated giant cells in the superficial and deep dermis. In the deep dermis, prominent eosinophilic degenerated collagen fibres with surrounding macrophages ('floating sign') occurred. In contrast to most previously describe