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Sample records for ionov i anion-radikalami

  1. Juno I -- Explorer I

    NASA Technical Reports Server (NTRS)

    1958-01-01

    Juno I, a slightly modified Jupiter-C launch vehicle, shortly before the January 31, 1958 launch of America's first satellite, Explorer I. The Jupiter-C, developed by Dr. Wernher von Braun and the rocket team at Redstone Arsenal in Huntsville, Alabama, consisted of a modified version of the Redstone rocket's first stage and two upper stages of clustered Baby Sergeant rockets developed by the Jet Propulsion Laboratory.

  2. Should I Floss?

    MedlinePlus

    ... teeth and mouth change in every stage of life. More RSS Feeds Get dental news feeds delivered directly to your desktop! more... Should I Floss? Article Chapters Should I Floss? Flossing print full article ...

  3. I3P Overview

    NASA Video Gallery

    Deborah Diaz, the NASA's Deputy Chief Information Officer, talks about the Information Technology Infrastructure Integration Program (I3P). I3P is NASA's initiative to provide Agency-wide managemen...

  4. Ares I Operability Overview

    NASA Technical Reports Server (NTRS)

    Shaughnessy, Raymond W.

    2009-01-01

    A general overview of Ares I Operability is presented. The contents include: 1) Vehicle and Ops Concept Overviews; 2) What does operability mean to the Ares I Project?; 3) What is the Ares Project doing to influence operability into the flight hardware designs?; and 4) How do we measure Ares I Project success in infusing operability?

  5. Can I Prevent Acne?

    MedlinePlus

    ... I Help a Friend Who Cuts? Can I Prevent Acne? KidsHealth > For Teens > Can I Prevent Acne? Print A A A Text Size What's ... too. Although there is no surefire way to prevent acne, try these tips to help reduce the ...

  6. Quantized Algebra I Texts

    ERIC Educational Resources Information Center

    DeBuvitz, William

    2014-01-01

    I am a volunteer reader at the Princeton unit of "Learning Ally" (formerly "Recording for the Blind & Dyslexic") and I recently discovered that high school students are introduced to the concept of quantization well before they take chemistry and physics. For the past few months I have been reading onto computer files a…

  7. Crystallization of lysozyme with (<i>R>)-, (<i>S>)- and (<i>RS>)-2-methyl-2,4-pentanediol

    SciTech Connect

    Stauber, Mark; Jakoncic, Jean; Berger, Jacob; Karp, Jerome M.; Axelbaum, Ariel; Sastow, Dahniel; Buldyrev, Sergey V.; Hrnjez, Bruce J.; Asherie, Neer

    2015-03-01

    Chiral control of crystallization has ample precedent in the small-molecule world, but relatively little is known about the role of chirality in protein crystallization. In this study, lysozyme was crystallized in the presence of the chiral additive 2-methyl-2,4-pentanediol (MPD) separately using the <i>R> and <i>S> enantiomers as well as with a racemic <i>RS> mixture. Crystals grown with (<i>R>)-MPD had the most order and produced the highest resolution protein structures. This result is consistent with the observation that in the crystals grown with (<i>R>)-MPD and (<i>RS>)-MPD the crystal contacts are made by (<i>R>)-MPD, demonstrating that there is preferential interaction between lysozyme and this enantiomer. These findings suggest that chiral interactions are important in protein crystallization.

  8. "i" Am Needed

    ERIC Educational Resources Information Center

    Scott, Paul

    2010-01-01

    The mysteries of mathematics are not easily revealed. Much of present day school mathematics is the product of years, sometimes centuries, of inquiring, wrestling and discovering by men of the highest intellect. The number "i" (designation for the square root of -1) is no exception. This article presents a lesson on the need for "i".

  9. Ovarian Cancer Stage I

    MedlinePlus

    ... hyphen, e.g. -historical Searches are case-insensitive Ovarian Cancer Stage I Add to My Pictures View /Download : ... 1650x675 View Download Large: 3300x1350 View Download Title: Ovarian Cancer Stage I Description: Three-panel drawing of stage ...

  10. Thallium (I), soluble salts

    Integrated Risk Information System (IRIS)

    Thallium ( I ) , soluble salts ; CASRN Various Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarc

  11. Comparative genomics of <i>Fructobacillus> spp. and <i>Leuconostoc> spp. reveals niche-specific evolution of <i>Fructobacillus> spp.

    SciTech Connect

    Endo, Akihito; Tanizawa, Yasuhiro; Tanaka, Naoto; Maeno, Shintaro; Kumar, Himanshu; Shiwa, Yuh; Okada, Sanae; Yoshikawa, Hirofumi; Dicks, Leon; Nakagawa, Junichi; Arita, Masanori

    2015-12-29

    In this study, <i>Fructobacillus> spp. in fructose-rich niches belong to the family <i>Leuconostocaceae>. They were originally classified as <i>Leuconostoc> spp., but were later grouped into a novel genus, <i>Fructobacillus> , based on their phylogenetic position, morphology and specific biochemical characteristics. The unique characters, so called fructophilic characteristics, had not been reported in the group of lactic acid bacteria, suggesting unique evolution at the genome level. Here we studied four draft genome sequences of <i>Fructobacillus> spp. and compared their metabolic properties against those of <i>Leuconostoc> spp. As a result, <i>Fructobacillus> species possess significantly less protein coding sequences in their small genomes. The number of genes was significantly smaller in carbohydrate transport and metabolism. Several other metabolic pathways, including TCA cycle, ubiquinone and other terpenoid-quinone biosynthesis and phosphotransferase systems, were characterized as discriminative pathways between the two genera. The adhE gene for bifunctional acetaldehyde/alcohol dehydrogenase, and genes for subunits of the pyruvate dehydrogenase complex were absent in <i>Fructobacillus> spp. The two genera also show different levels of GC contents, which are mainly due to the different GC contents at the third codon position. In conclusion, the present genome characteristics in <i>Fructobacillus> spp. suggest reductive evolution that took place to adapt to specific niches.

  12. I'm Pregnant. Should I Get a Flu Shot?

    MedlinePlus

    ... Cuts? I'm Pregnant. Should I Get a Flu Shot? KidsHealth > For Teens > I'm Pregnant. Should I Get a Flu Shot? Print A A A Text Size I ... weeks pregnant. Do I need to get the flu vaccine or will it affect my pregnancy? – Eliza* ...

  13. I Have Braces: How Can I Eat Fruits and Veggies?

    MedlinePlus

    ... Cuts? I Have Braces. How Can I Eat Fruits and Veggies? KidsHealth > For Teens > I Have Braces. How Can I Eat Fruits and Veggies? Print A A A Text Size ... weight. I read about eating 5 servings of fruits and veggies a day. But I can't ...

  14. How Can I Manage Stress?

    MedlinePlus

    ... Can I Quit Smoking? How Can I Manage Stress? How Can I Make My Lifestyle Healthier? How Can I Monitor My Cholesterol, Blood Pressure and Weight? Popular Articles 1 Understanding Blood Pressure ...

  15. Radiological assistance program: Region I. Part I

    SciTech Connect

    Musolino, S.V.; Kuehner, A.V.; Hull, A.P.

    1985-07-15

    The purpose of the Radiological Assistance Program (RAP) is to make DOE resources available and provide emergency assistance to state and local agencies in order to control radiological hazards, protect the public health and safety, and minimize the loss of property. This plan is an integral part of a nationwide program of radiological assistance established by the US DOE, and is implemented on a regional basis. The Brookhaven Area Office (BHO) Radiological Assistance Program is applicable to DOE Region I, which consists of the New England States, New York, New Jersey, Pennsylvania, Delaware, Maryland and the District of Columbia. The BHO RAP-1 has been developed to: (a) ensure the availability of an effective radiological assistance capability to ensure the protection of persons and property; (b) provide guidelines to RAP-1 Team personnel for the evaluation of radiological incidents and implementation of corrective actions; (c) maintain liaison with other DOE installations, Federal, State and local organizations which may become involved in radiological assistance operations in Region I; and (d) encourage development of a local capability to cope with radiological incidents.

  16. Collider Signal I :. Resonance

    NASA Astrophysics Data System (ADS)

    Tait, Tim M. P.

    2010-08-01

    These TASI lectures were part of the summer school in 2008 and cover the collider signal associated with resonances in models of physics beyond the Standard Model. I begin with a review of the Z boson, one of the best-studied resonances in particle physics, and review how the Breit-Wigner form of the propagator emerges in perturbation theory and discuss the narrow width approximation. I review how the LEP and SLAC experiments could use the kinematics of Z events to learn about fermion couplings to the Z. I then make a brief survey of models of physics beyond the Standard Model which predict resonances, and discuss some of the LHC observables which we can use to discover and identify the nature of the BSM physics. I finish up with a discussion of the linear moose that one can use for an effective theory description of a massive color octet vector particle.

  17. I Remember Highlander

    ERIC Educational Resources Information Center

    Williams-Hawkins, Maria

    2016-01-01

    "I Remember Highlander" reflects on the life choices of Marion Barry and Herman Henning Jr., fraternity brothers who sought the same goal but took different paths. The essay examines cultural and family situations that shaped lives and decisions.

  18. Why Am I Dizzy?

    MedlinePlus Videos and Cool Tools

    ... I Dizzy?" A few of the more common balance orders that affect older adults are labyrinthitis, Ménière's ... courtesy of Johns Hopkins Center for Hearing and Balance and the Vestibular Disorders Association (VEDA).

  19. iCARE

    Cancer.gov

    The iCARE R Package allows researchers to quickly build models for absolute risk, and apply them to estimate an individual's risk of developing disease during a specifed time interval, based on a set of user defined input parameters.

  20. Apps I Have Loved

    ERIC Educational Resources Information Center

    Schaffhauser, Dian

    2011-01-01

    According to a March estimate from Distimo, there were 653,614 apps in the iPhone, Android, iPad, BlackBerry, and Windows Mobile stores alone. So, is it any wonder that these busy people have found a few that come in handy on the job? Mobile apps are as indispensable to district IT executives as they are becoming in the classroom--for professional…

  1. Why I Love Vendors

    SciTech Connect

    Wiley, H. S.

    2010-02-01

    In December, I attended the annual meeting of the American Society for Cell Biology, as I have done regularly for the last several decades. It is always a good way to catch up with old friends and look for the latest trends in cell biology. I rarely attend the talks, having found that they more reflect the fashion of the moment (or the past) than the direction of the field. Poster sessions are more to my liking, since they provide a chance to talk to enthusiastic young scientists in the trenches. But my favorite stop has always been the vendor booths. When I tell my friends that I love visiting vendor booths, most of them seem to think I am kidding. At meetings, many scientists seem to feel that vendors are necessary evils. They provide free candy and cheap pens in exchange for bombarding us with ads and scanning our badges. Like popup ads in web browsers, we have learned to both ignore and accept them as part of the landscape. It is unfortunate that we have become so inured to their presence. Talks and posters capture exciting research from the last few years or months, but vendor booths capture the future, offering one of the clearest visions of where a field is going.

  2. Ares I Avionics Introduction

    NASA Technical Reports Server (NTRS)

    Marchant, Christopher C.

    2009-01-01

    The Ares I is the next generation human-rated launcher for the United States Constellation program. This system is required to provide single fault tolerance within defined crew safety and mission reliability limits. As part of the effort to achieve those safety goals, Ares I includes an avionics subsystem built as a multistring, voting architecture. The avionics design draws upon experience gained from building fly-by-wire systems for Shuttle, X- 38, and Seawolf. Architectural drivers for the avionics design include using proven technologies with existing suppliers of space rated parts for critical functions (to reduce overall development risk), easing the software development effort by using an off-theshelf, DO-178B certifiable, ARINC-653 operating system in the main flight computers, minimizing mutual data and power connections that might lead to a common-mode hardware failure of the redundant avionics strings, and centralizing overall Ares I command & control within the Upper Stage.

  3. 129I and 127I transport in the Mississippi River.

    PubMed

    Oktay, S D; Santschi, P H; Moran, J E; Sharma, P

    2001-11-15

    The watershed processes which control 129I/127I ratios, 129I and 127I concentrations, and speciation of iodine isotopes were studied through an investigation into the variability of these parameters in the Mississippi River near New Orleans, undertaken in 1996-1998. Analyses of suspended particulate matter (SPM) revealed a greater percent association of 127I than of 129I, resulting in lower 129I/127I ratios in SPM than in surrounding water. Furthermore, crossflow ultrafiltration showed that organo-iodine was the dominant form for both isotopes, with 70-85% of these isotopes found in the 0.45 microm filter-passing fraction associated with colloidal macromolecular organic matter. 129I showed a weak correlation, 127I no correlation, and 129I/127I ratios a strong inverse correlation with river flow rate. Inverse correlations between 129I/127I ratios and river flow rates can be best explained by rainwater and evapotranspiration dominated ratios at base flow and a lowering of the isotope ratios during higher flow due to extra inputs of 127I from soil weathering. We postulate that different equilibration times for 127I and 129I as well as for bomb-produced 129I and reprocessing-produced 129I are responsible for these fractionation effects and the differential mobilities of these isotopes in the Mississippi River watershed. PMID:11757603

  4. [Acrocephalosyndactyly I (Apert syndrome)].

    PubMed

    Linss, G

    2000-09-01

    A fourteen years old girl showed the classic signs of acrocephalosyndactyly I: dysostosis craniofacialis with hypertelorism, exophthalmus, strabism, amblyopia and cleft palate as well as syndactyly of the fingers and toes. The feet showed on both side a 6 cm long horny band. Since the twelfth year of life, she had suffered from papulo-pustular acne with many comedomes. Her menstruation started one year later. Intellectual development was normal. At time of her birth, her father was 54 years old, and her mother 36 years old. Two elder siblings are healthy. The inheritance of acrocephalosyndactyly I is usually autosomal dominant, but sporadic cases are frequent. PMID:11057397

  5. I-cell disease.

    PubMed

    Patel, Z M; Ambani, L M

    1980-01-01

    A 6-month-old female infant presented with severe psychomotor retardation, coarse facies, gingival hyperplasia, thick skin, restricted joint movements and radiological features suggestive of the Hurler syndrome. Her urine showed no excess excretion of mucopolysaccharides. I-cell disease was suspected from the onset of clinical features in early infancy, the subsequent progress and the absence of mucopolysacchariduria. Marked elevation of the activity in serum of three lysosomal enzymes confirmed the diagnosis. This patient had repeated convulsions, a feature not previously reported in this condition. This is the first case report of I-cell disease from India. PMID:6118467

  6. {sup 129}I Interlaboratory comparison: phase I and phase II

    SciTech Connect

    Caffee, M W; Roberts, M L

    1999-09-30

    An interlaboratory comparison exercise for {sup 129}I was organized and conducted. Nine laboratories participated in the exercise to either a full or limited extent. In Phase I of the comparison, 11 samples were measured. The suite of samples contained both synthetic ''standard type'' materials (i.e., AgI) and environmental materials. The isotopic {sup 129}I/{sup 127}I ratios of the samples varied from 10{sup {minus}8} to 10{sup {minus}14}. In this phase, each laboratory was responsible for its own chemical preparation of the samples. In Phase I, the {sup 129}I AMS measurements for prepared AgI were in good agreement. However, large discrepancies were seen in {sup 129}I AMS measurements of environmental samples. Because of the large discrepancies seen in the Phase I {sup 129}I intercomparison, a subsequent study was conducted. In Phase II of the {sup 129}I intercomparison, three separate laboratories prepared AgI from two environmental samples (IAEA 375 soil and maples leaves). Each laboratory used its own chemical preparation method with each of the methods being distinctly different. The resulting six samples (two sets of three) were then re-distributed to the participating {sup 129}I AMS facilities and {sup 129}I/{sup 127}I ratios measured. Results and discussion of both the Phase I and Phase II interlaboratory comparison are presented.

  7. Library Studies I Workbook.

    ERIC Educational Resources Information Center

    Frost, William J.

    Developed for use in the Library Studies I component of the Library Studies Program at Bloomsburg University (Pennsylvania), this self-paced workbook is intended to acquaint students with the Harvey A. Andruss Library and help them develop information-seeking skills. The workbook is designed to be used in conjunction with an exercise book, and…

  8. I Need A Friend.

    ERIC Educational Resources Information Center

    Montgomery, Charlotte Baker

    1980-01-01

    Contains the second part of the "I Need a Friend" Copy Master Series designed for use by educators to teach children about the responsibilities humans have for their fellow creatures. The stories can be reproduced for distribution to students or used as a coloring book. (Author/SA)

  9. iBank

    ERIC Educational Resources Information Center

    Bermundo, Cesar B.; Bermundo, Alex B.; Ballester, Rex C.

    2012-01-01

    iBank is a project that utilizes a software to create an item Bank that store quality questions, generate test and print exam. The items are from analyze teacher-constructed test questions that provides the basis for discussing test results, by determining why a test item is or not discriminating between the better and poorer students, and by…

  10. I Hate Reviews!

    NASA Technical Reports Server (NTRS)

    Little, Terry

    2003-01-01

    In our business we have all kinds of reviews: financial reviews, strategy reviews, technical reviews, test reviews, design reviews, baseline reviews, etc., etc. Some ways to avoid the most common pitfalls that I find specifically in these kinds of reviews are given.

  11. Meatcutting Testbook, Part I.

    ERIC Educational Resources Information Center

    Strazicich, Mirko, Ed.

    This document contains objective tests for each lesson in the Meatcutting Workbook, Part I (see note), which is designed for apprenticeship programs in meatcutting in California. Each of the 36 tests contains from 10 to 45 multiple-choice items. The tests are grouped according to the eight units of the workbook: the apprentice meatcutter; applied…

  12. SSIP Phase I Roadmap

    ERIC Educational Resources Information Center

    Vinh, Megan; Lucas, Anne; Taylor, Cornelia; Kelley, Grace; Kasprzak, Christina

    2014-01-01

    This roadmap provides a description of the activities involved in the development of the State Systemic Improvement Plan (SSIP) (SPP/APR Indicators C11 and B17) due to the Office of Special Education Programs (OSEP) on April 1, 2015. The roadmap is intended to support states with completing Phase I of the SSIP process. This document provides…

  13. Laser Geodynamics Satellite I

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The LAGEOS I (Laser Geodynamics Satellite) was developed and launched by the Marshall Space Flight Center on May 4, 1976 from Vandenberg Air Force Base, California . The two-foot diameter satellite orbited the Earth from pole to pole and measured the movements of the Earth's surface.

  14. "I Spy" Engaged Learners.

    ERIC Educational Resources Information Center

    Sassano, Lisa

    2003-01-01

    Encourages student awareness of the connections between their classroom experiences and real life. Develops an idea to motivate and keep track of students' findings, the "I Spy Vocab Words" contest. Describes how the author implemented the contest. Notes how the program has students keep a log of vocabulary words they find in their everyday lives.…

  15. Alexander I. Ignatowski

    PubMed Central

    Konstantinov, Igor E.; Jankovic, Gradimir M.

    2013-01-01

    In 1908, Alexander I. Ignatowski (1875–1955) published his pioneering work that first revealed a relationship between cholesterol-rich food and experimental atherosclerosis. This early experimental work paved a way to the metabolic study of the mechanism of atherosclerosis. Herein, we present a brief account of Ignatowski's work and life. PMID:23914012

  16. Astronaut Virgil I. Grissom

    NASA Technical Reports Server (NTRS)

    1959-01-01

    Astronaut Virgil I. 'Gus' Grissom, one of the original seven astronauts for Mercury Project selected by NASA on April 27, 1959. The MR-4 mission, boosted by the Mercury-Redstone vehicle, made the second marned suborbital flight. The capsule, Liberty Bell 7, sank into the sea after the splashdown.

  17. Methods & Strategies: I Wonder...

    ERIC Educational Resources Information Center

    Stevenson, Anne

    2013-01-01

    "I Wonder" boards are a teaching strategy that can be used in the classroom, as well as during science learning opportunities in nonformal settings, such as after-school science programs or summer camps.This simple strategy has led to deeper science exploration in 4-H, as young people learn alongside program staff, teachers, or…

  18. Big Brother I. Q.

    ERIC Educational Resources Information Center

    Gilliatt, Michael T.

    1977-01-01

    Lists four harmful consequences that critics suggest educational testing may have, and in discussing the danger that I.Q. testing may place an indelible stamp of inferiority upon students, this research re-examines the purpose of testing. (Author/RK)

  19. Amarcord: I Remember

    PubMed Central

    Carafoli, Ernesto

    2013-01-01

    I have tried to offer a historical account of a success story, as I saw it develop from the early times when it interested only a few aficionados to the present times when it has pervaded most of cell biochemistry and physiology. It is of course the story of calcium signaling. It became my topic of work when I was a young postdoctoral fellow at The Johns Hopkins University. I entered it through a side door, that of mitochondria, which had been my area of work during my earlier days in Italy. The 1960s and 1970s were glorious times for mitochondrial calcium signaling, but the golden period was not going to last. As I have discussed below, mitochondrial calcium gradually lost appeal, entering a long period of oblivion. Its fading happened as the general area of calcium signaling was instead experiencing a phase of explosive growth, with landmark discoveries at the molecular and cellular levels. These discoveries established that calcium signaling was one of the most important areas of cell biology. However, mitochondria as calcium partners were not dead; they were only dormant. In the 1990s, they were rescued from their state of neglect to the central position of the regulation of cellular calcium signaling, which they had once rightly occupied. Meanwhile, it had also become clear that calcium is an ambivalent messenger. Hardly anything important occurs in cells without the participation of the calcium message, but calcium must be controlled with absolute precision. This is an imperative necessity, which becomes unfortunately impaired in a number of disease conditions that transform calcium into a messenger of death. PMID:23836917

  20. Near-complete genome sequence of the cellulolytic Bacterium <i>Bacteroides> (<i>Pseudobacteroides>) <i>cellulosolvens> ATCC 35603

    SciTech Connect

    Dassa, Bareket; Utturkar, Sagar M.; Hurt, Richard A.; Klingeman, Dawn Marie; Keller, Martin; Xu, Jian; Reddy, Harish Kumar; Borovok, Ilya; Grinberg, Inna Rozman; Lamed, Raphael; Zhivin, Olga; Bayer, Edward A.; Brown, Steven D.

    2015-09-24

    We report the single-contig genome sequence of the anaerobic, mesophilic, cellulolytic bacterium, <i>Bacteroides cellulosolvensi>. The bacterium produces a particularly elaborate cellulosome system, whereas the types of cohesin-dockerin interactions are opposite of other known cellulosome systems: cell-surface attachment is thus mediated via type-I interactions whereas enzymes are integrated via type-II interactions.

  1. Average and local crystal structures of (Ga1–<i>xi>Znx>)(N1–<i>xOx>) solid solution nanoparticles

    SciTech Connect

    Feygenson, Mikhail; Neuefeind, Joerg C.; Tyson, Trevor A.; Schieber, Natalie; Han, Wei -Qiang

    2015-11-06

    We report the comprehensive study of the crystal structure of (Ga1–<i>xi>Znx>)(N1–<i>xOx>) solid solution nanoparticles by means of neutron and synchrotron x-ray scattering. In our study we used four different types of (Ga1–<i>xi>Znx>)(N1–<i>xOx>) nanoparticles, with diameters of 10–27 nm and x = 0.075–0.51, which show the narrow energy-band gaps from 2.21 to 2.61 eV. The Rietveld analysis of the neutron diffraction data revealed that the average crystal structure is the hexagonal wurtzite (space group P63mc), in agreement with previous reports on similar bulk materials. The pair-distribution function (PDF) analysis of the same data found that the local structure is more disordered than the average one. It is best described by the model with a lower symmetry space group P1, where atoms are quasirandomly distorted from their nominal positions in the hexagonal wurtzite lattice.

  2. Fermentation of dilute acid pretreated <i>Populus> by <i>Clostridium thermocellumi>, <i>Caldicellulosiruptor besciii>, and <i>Caldicellulosiruptor obsidiansisi>

    SciTech Connect

    Yee, Kelsey L.; Rodriguez, Jr., Miguel; Hamilton, Choo Yieng; Hamilton-Brehm, Scott D.; Thompson, Olivia A.; Elkins, James G.; Davison, Brian H.; Mielenz, Jonathan R.

    2015-07-25

    Consolidated bioprocessing (CBP), which merges enzyme production, biomass hydrolysis, and fermentation into a single step, has the potential to become an efficient and economic strategy for the bioconversion of lignocellulosic feedstocks to transportation fuels or chemicals. In this study, we evaluated <i>Clostridium thermocellumi>, <i>Caldicellulosiruptor besciii>, and <i>Caldicellulosiruptor obsidiansisi>, three , thermophilic,cellulolytic, mixed-acid fermenting candidate CBP microorganisms, for their fermentation capabilities using dilute acid pretreated <i>Populus> as a model biomass feedstock. Under pH controlled, anaerobic fermentation conditions, each candidate successfully digested a minimum of 75% of the cellulose from dilute acid pretreated <i>Populus>, as indicated by an increase in planktonic cells and end-product metabolites and a concurrent decrease in glucan content. <i>C. thermocellumi>, which employs a cellulosomal approach to biomass degradation, required 120 hours to achieve 75% cellulose utilization. In contrast, the non-cellulosomal, secreted hydrolytic enzyme system of the <i>Caldicellulosiruptor> sp. required 300 hours to achieve similar results. End-point fermentation conversions for <i>C. thermocellumi>, <i>C. besciii>, and <i>C. obsidiansisi> were determined to be 0.29, 0.34, and 0.38 grams of total metabolites per gram of loaded glucan, respectively. This data provide a starting point for future strain engineering efforts that can serve to improve the biomass fermentation capabilities of these three promising candidate CBP platforms.

  3. 129I interlaboratory comparison: phase I and phase II results

    SciTech Connect

    Roberts, M.I.; Caffee, M.W.; Proctor, I.D.

    1997-07-01

    An interlaboratory comparison exercise for 129I was organized and conducted. A total of nine laboratories participated in the exercise to either a full or limited extent. In Phase I of the comparison, a suite of 11 samples were measured. The suite of samples contained both synthetic `standard type` materials (i.e., AgI) and environmental materials. The isotopic 129I/127I ratios of the samples varied from 10`-8 to 10`-14. In this phase, each laboratory was responsible for its own chemical preparation of the environmental samples. The 129I AMS measurements obtained at different laboratories for prepared AgI were in good agreement. However, large discrepancies were seen in 129I AMS measurements of environmental samples. Because of the large discrepancies seen in the Phase I intercomparison, a subsequent study was conducted. In Phase II of the comparison, AgI was prepared from two environmental samples (IAEA 375 soil and maples leaves) by three separate laboratories. Each laboratory used its own chemical preparation method with each of the methods being distinctly different. The resulting six samples (two sets of three) were then redistributed to the participating 129I AMS facilities and 129I/127I ratios measured. Results and discussion of both the Phase I and Phase II interlaboratory comparison are presented.

  4. Father and I

    NASA Astrophysics Data System (ADS)

    Yang, Chen Ning

    2013-05-01

    Father (K. C. Yang (楊克純), 1896-1973) was a high school teacher in Anqing (安慶) in 1922 when I was born in Hefei (合肥). Anqing was then also called Huaining (懷寧). Father gave me the name Chen Ning, of which Chen was the name of my generation in our family, and Ning was derived from Huaining. Before I was one year old Father won an Anhui (安徽) Provincial Fellowship for studying in the USA. We had a family picture (Figure 1) taken in the courtyard outside our bedroom a few days before he left home. Father had on the traditional robe and coat, standing stiff and erect. He had probably up to that point never worn a western suit. Two years later he sent a picture (Figure 2) to Mother from the University of Chicago, in which his attire and bearing had both entered the twentieth century. Father was a handsome man. The exuberance and optimism of his youth were clearly captured in this photograph...

  5. Endometrial carcinoma stage I.

    PubMed

    Baram, A; Ron, I; Kupferminc, M; Inbar, M

    1997-01-01

    Standard staging and therapeutic approach to endometrial cancer involves lymph node sampling (LNS) at the time of total abdominal hysterectomy (TAH) and bilateral salpingo-oophorectomy (BSO). Lymphadenectomy prolongs time of surgery and increases the risk of morbidity; where other predictors are available, it may not contribute important supplementary information. 185/247 women with stage I endometrial carcinoma underwent the standard surgery while 62 underwent TAH+BSO. Recurrence and survival were monitored for a mean of 6.5 years and retrospectively reviewed: the rates for groups with and without known lymph node status were alike [13.5% (25/185) recurrence for the former and 12.9% (8/62) for the latter, and 5-year survival rates of 75.7% (140/185) for the former and 74.2 (46/62) for the latter]. Myometrial invasion and histological grade appeared to have been highly accurate predictors without lymph node information. Because information on histological grade is available early and is highly predictive, its use could be incorporated into a revised management algorithm for stage I endometrial cancer which would depend upon ensuring lymphadenectomy for women with low grade histopathology and omitting it for those with high grades on the grounds that no further information is necessary to act appropriately. PMID:21590195

  6. Testing Students for Title I Eligibility: ESEA Title I.

    ERIC Educational Resources Information Center

    Austin Independent School District, TX. Office of Research and Evaluation.

    A guide for administrators' use in determining Elementary Secondary Education Act Title I eligibility of students in their schools is divided into five sections. Section I describes four rules which must be followed in identifying Title I students, and which will be monitored during the year by consultants visiting the school. Section II suggests…

  7. Delirium Research: Where Am I?

    MedlinePlus

    ... please turn JavaScript on. Feature: Delirium Research Where Am I? Past Issues / Fall 2015 Table of Contents ... to do. Read More "Delirium Research" Articles Where Am I? / Digging Into the Mysteries of Delirium / The ...

  8. Adding Zingers to Course I.

    ERIC Educational Resources Information Center

    Kalman, Richard

    1996-01-01

    This article presents problems to challenge students over and above the standard curriculum problems assigned at a Course I level. Every additional problem in the article can be solved using only the tools provided by Course I. (AIM)

  9. Planning for RtI

    ERIC Educational Resources Information Center

    Robins, Jennifer; Antrim, Patricia

    2013-01-01

    In 2004 the Individuals with Disabilities Education Act authorized funding for Response to Intervention (RtI) instruction in the United States. By 2011, 71 percent of school districts had adopted RtI (Institute of Education Sciences 2011). The goal of RtI is to provide personalized, just-in-time intervention in reading and math for students who…

  10. A Title I Refinement: Alaska.

    ERIC Educational Resources Information Center

    Hazelton, Alexander E.; And Others

    Through joint planning with a number of school districts and the Region X Title I Technical Assistance Center, and with the help of a Title I Refinement grant, Alaska has developed a system of data storage and retrieval using microcomputers that assists small school districts in the evaluation and reporting of their Title I programs. Although this…

  11. Metabolomic profiling of the nectars of <i>Aquilegia pubescensi> and <i>A. Canadensisi>

    SciTech Connect

    Noutsos, Christos; Perera, Ann M.; Nikolau, Basil J.; Seaver, Samuel M. D.; Ware, Doreen H.; Motta, Andrea

    2015-05-01

    To date, variation in nectar chemistry of flowering plants has not been studied in detail. Such variation exerts considerable influence on pollinator–plant interactions, as well as on flower traits that play important roles in the selection of a plant for visitation by specific pollinators. Over the past 60 years the <i>Aquilegia> genus has been used as a key model for speciation studies. In this study, we defined the metabolomic profiles of flower samples of two <i>Aquilegia> species, <i>A. Canadensisi> and <i>A. pubescensi>. We identified a total of 75 metabolites that were classified into six main categories: organic acids, fatty acids, amino acids, esters, sugars, and unknowns. The mean abundances of 25 of these metabolites were significantly different between the two species, providing insights into interspecies variation in floral chemistry. Using the PlantSEED biochemistry database, we found that the majority of these metabolites are involved in biosynthetic pathways. Finally, we explored the annotated genome of <i>A. coeruleai>, using the PlantSEED pipeline and reconstructed the metabolic network of <i>Aquilegia>. This network, which contains the metabolic pathways involved in generating the observed chemical variation, is now publicly available from the DOE Systems Biology Knowledge Base (KBase; http://kbase.us).

  12. Successful I.D. Encounters.

    ERIC Educational Resources Information Center

    Poorman, Margaret J.

    Instructional Development (I.D.) encounters are dependent for success on such variables as power, politics, promotion, and organizational placement. I.D. consultants must be aware of power bases or orientation of other personnel and clients, e.g., these four "power personalities" which affect their efforts in managing I.D. encounters: the gate…

  13. 'Who am I?'.

    PubMed

    Schellinski, Kristina

    2014-04-01

    The dreams and existential questions of those, who came into being in order to replace a dead person, pivot around a central cry: 'Who am I?' If conceived, born or designated as a replacement child, such an individual may suffer-even as an adult-from a rarely recognized unconscious confusion of identity, compounded by grief and survivors' guilt. From before the child is born, the archetypal forces of death and life are joined in a fateful constellation; the soul of the replacement child bears the shadow of death from the very beginning of life. Hope for the replacement child lies in an emergence of true self as soul recreates original life. Analysis can help the replacement child experience a 'rebirth into true life', not as 'the one who returned', but as a psychologically newborn individual; the path of individuation countering the replacement child's identification with the dead. Jungian analysis offers unique concepts for understanding and healing the replacement child; C.G. Jung himself was born after two stillborn babies and an infant that lived only five days. PMID:24673274

  14. Find Quality Resources: How Do I Know if I Can Trust the Informaton I Find Online?

    MedlinePlus

    ... Your Medical Record Support family caregivers Find Quality Resources How do I know if I can trust ... Food and Drug Administration . Are the tools or resources easily usable? On a web site, is it ...

  15. {sup 129}I interlaboratory comparison

    SciTech Connect

    Roberts, M.L.; Caffee, M.W.; Proctor, L.D.

    1996-05-01

    An interlaboratory comparison exercise for {sup 129}I has been organized and conducted. A total of seven laboratories participated in the exercise to either a full or limited extent. In the comparison, a suite of 11 samples were used. This suite of standards contained both synthetic `standard type` materials(i.e., AgI) and environmental materials. The isotopic {sup 129}I/{sup 127}I ratio of the samples varied from 10{sup -8} to 10{sup -14}. Preliminary results of the comparison are presented.

  16. 40 CFR Table I-5 to Subpart I - Table I-5 to Subpart I of Part 98-Table I-5 to Subpart I of Part 98-Default Emission Factors (1...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... By-Product Formation Rates (Bijk) for MEMS Manufacturing I Table I-5 to Subpart I Protection of... REPORTING Electronics Manufacturing Pt. 98, Subpt. I, Table I-5 Table I-5 to Subpart I—Table I-5 to Subpart... Rates (Uij) and By-Product Formation Rates (Bijk) for MEMS Manufacturing Process type factors...

  17. Static Firing of the Saturn I S-I Stage

    NASA Technical Reports Server (NTRS)

    1961-01-01

    The Saturn project was approved on January 18, 1960 as a program of the highest national priority. The formal test program to prove out the clustered-booster concept was well underway. A series of static tests of the Saturn I booster (S-I stage) began June 3, 1960 at the Marshall Space Flight Center (MSFC). This photograph depicts the Saturn I S-I stage equipped with eight H-1 engines, being successfully test-fired on February 4, 1961. A Juno rocket is visible on the right side of the test stand.

  18. Skin exposure to I blocks thyroid uptake of 131I.

    PubMed

    Miller, K L; White, W J; Lang, C M; Weidner, W A

    1985-11-01

    Radioisotopes of I pose an important health risk to man in nuclear accidents associated with electric power generation due to their uptake by the thyroid glands. Topical application of tincture of I or povidone-iodine to the skin of rats has been found to be as effective as oral administration of potassium iodide in blocking thyroid uptake of parenterally administered 131I. If the same effectiveness can be demonstrated in humans, this may be an attractive alternative method of mass protection from radioisotopes of I following nuclear accidents. PMID:4066341

  19. Frontiers of <i>in situi> electron microscopy

    SciTech Connect

    Zheng, Haimei; Zhu, Yimei; Meng, Shirley Ying

    2015-01-01

    <i>In situi> transmission electron microscopy (TEM) has become an increasingly important tool for materials characterization. It provides key information on the structural dynamics of a material during transformations and the correlation between structure and properties of materials. With the recent advances in instrumentation, including aberration corrected optics, sample environment control, the sample stage, and fast and sensitive data acquisition, in situ TEM characterization has become more and more powerful. In this article, a brief review of the current status and future opportunities of in situ TEM is included. It also provides an introduction to the six articles covered by in this issue of <i>MRS Bulletini> explore the frontiers of <i>in situi> electron microscopy, including liquid and gas environmental TEM, dynamic four-dimensional TEM, nanomechanics, ferroelectric domain switching studied by <i>in situi> TEM, and state-of-the-art atomic imaging of light elements (i.e., carbon atoms) and individual defects.

  20. Complete genome sequence of <i>Planctomyces brasiliensisi> type strain (DSM 5305T), phylogenomic analysis and reclassification of <i>Planctomycetes> including the descriptions of <i>Gimesia> gen. nov.,<i> Planctopirusi> gen. nov. and <i>Rubinisphaera> gen. nov. and emended descriptions of the order <i>Planctomycetales> and the family <i>Planctomycetaceae>

    SciTech Connect

    Scheuner, Carmen; Tindall, Brian J.; Lu, Megan; Nolan, Matt; Lapidus, Alla L.; Cheng, Jan-Fang; Goodwin, Lynne A.; Pitluck, Sam; Huntemann, Marcel; Liolios, Konstantinos; Pagani, Ioanna; Mavromatis, Konstantinos; Ivanova, Natalia; Pati, Amrita; Chen, Amy; Palaniappan, Krishna; Jeffries, Cynthia D.; Hauser, Loren John; Land, Miriam L.; Mwirichia, Romano; Rohde, Manfred; Abt, Birte; Detter, John Chris; Woyke, Tanja; Eisen, Jonathan A.; Markowitz, Victor; Hugenholtz, Philip; Goker, Markus; Kyrpides, Nikos C.; Klenk, Hans-Peter

    2014-12-08

    <i>Planctomyces brasiliensisi> Schlesner 1990 belongs to the order <i>Planctomycetales>, which differs from other bacterial taxa by several distinctive features such as internal cell compartmentalization, multiplication by forming buds directly from the spherical, ovoid or pear-shaped mother cell and a cell wall consisting of a proteinaceous layer rather than a peptidoglycan layer. The first strains of <i>P. brasiliensisi>, including the type strain IFAM 1448 T, were isolated from a water sample of Lagoa Vermelha, a salt pit near Rio de Janeiro, Brasil. This is the second completed genome sequence of a type strain of the genus <i>Planctomyces> to be published and the sixth type strain genome sequence from the family <i>Planctomycetaceae>. The 6,006,602 bp long genome with its 4,811 protein-coding and 54 RNA genes is a part of the Genomic Encyclopedia of Bacteria and Archaea project. We study phylogenomic analyses that indicate that the classification within the <i>Planctomycetaceae> is partially in conflict with its evolutionary history, as the positioning of <i>Schlesneria> renders the genus <i>Planctomyces> paraphyletic. A re-analysis of published fatty-acid measurements also does not support the current arrangement of the two genera. A quantitative comparison of phylogenetic and phenotypic aspects indicates that the three <i>Planctomyces> species with type strains available in public culture collections should be placed in separate genera. Thus the genera <i>Gimesia, Planctopirusi> and <i>Rubinisphaera> are proposed to accommodate <i>P. maris, P. limnophilusi> and <i>P. brasiliensisi>, respectively. Pronounced differences between the reported G + C content of <i>Gemmata obscuriglobus, Singulisphaera acidiphilai> and <i>Zavarzinella formosai> and G + C content calculated from their genome sequences call for emendation of their species descriptions. Lastly, in addition to other features, the range of G + C values reported for

  1. Praxis I/O package

    SciTech Connect

    Holloway, F.W.; Sherman, T.A.

    1988-04-07

    The Praxis language specification, like Algol and Ada, does not specify any I/O statements. The intent was to provide a standard I/O package as a companion to the compiler. This would allow the user to substitute, or supplement, the I/O package, as needed, for specialized applications. Like Algol, however, Praxis provided only limited (text) I/O for several years. Ada, in contrast, provided a comprehensive standard I/O package from its inception. Digital Equipment Corporation's (DEC's) implementation of Ada, on their VAX family of computers, further supplemented this package with other packages which exploit the I/O facilities available under the VMS operating system. The Praxis I/O package described in this document has been modeled after DEC's implementation of Ada and provides a similar set of I/O facilities. Currently, the I/O package is supported only under VAX/VMS. The design of the package, however, is essentially independent of any operating system (with the exception of the module COMMAND IO). The VAX/VMS version of the I/O package fully exploits the vast I/O facilities which are provided under VAX/VMS and makes them directly available to the Praxis programmer. The design, prototype implementation, and draft documentation of the Praxis I/O Package was done by Tim Sherman as part of a University project in computer science. Subsequent work by both Tim and Fred Holloway lead to a more complete implementation, testing and development of example programs, and inclusion of the package into the Praxis compilers as their principal interface to RMS and VMS.

  2. Ares I Ares V Overview

    NASA Technical Reports Server (NTRS)

    Sumrall, Phil

    2009-01-01

    This slide presentation is an overview of the Ares I and Ares V projects. It includes a comparison of the launch vehicles from the Saturn V, the Space Shuttle, and the planned Ares I and Ares V. In order to reduce operating cost, the Ares and V will use much of the same hardware. The elements of the Ares I and V. are reviewed and there is a view of the upper stage avionics. The elements of the J-2X engine to be used on both the Ares I and V are viewed.

  3. The NO<i>v>A simulation chain

    SciTech Connect

    Aurisano, A.; Backhouse, C.; Hatcher, R.; Mayer, N.; Musser, J.; Patterson, R.; Schroeter, R.; Sousa, A.

    2015-12-23

    The NO<i>v>A experiment is a two-detector, long-baseline neutrino experiment operating in the recently upgraded NuMI muon neutrino beam. Simulating neutrino interactions and backgrounds requires many steps including: the simulation of the neutrino beam flux using FLUKA and the FLUGG interface, cosmic ray generation using CRY, neutrino interaction modeling using GENIE, and a simulation of the energy deposited in the detector using GEANT4. To shorten generation time, the modeling of detector-specific aspects, such as photon transport, detector and electronics noise, and readout electronics, employs custom, parameterized simulation applications. We will describe the NO<i>v>A simulation chain, and present details on the techniques used in modeling photon transport near the ends of cells, and in developing a novel data-driven noise simulation. Due to the high intensity of the NuMI beam, the Near Detector samples a high rate of muons originating in the surrounding rock. In addition, due to its location on the surface at Ash River, MN, the Far Detector collects a large rate ((˜) 140 kHz) of cosmic muons. Furthermore, we will discuss the methods used in NO<i>v>A for overlaying rock muons and cosmic ray muons with simulated neutrino interactions and show how realistically the final simulation reproduces the preliminary NO<i>v>A data.

  4. ESEA Title I Projects Evaluation Report 1967, Volume I.

    ERIC Educational Resources Information Center

    Pittsburgh Public Schools, PA.

    Reports of Pittsburgh's 1967 ESEA Title I projects are presented in two volumes. The 17 reports in Volume I, which adhere to the procedures established in an evaluation model, are of programs in communication skills, camping, vocational education, music, standard English, social development, revised class organization, remedial reading by means of…

  5. Spectroscopic Data of W I, Mo I and Cr I Spectral Lines: Selection and Analysis

    NASA Astrophysics Data System (ADS)

    Veklich, A. N.; Lebid, A. V.; Tmenova, T. A.

    2015-12-01

    Plasma of electric arc discharges between composite Cu-W, Cu-Mo and Cu-Cr electrodes in argon flow and their spectra were studied by optical emission spectroscopy. Since values of oscillator strengths for W I, Mo I and Cr I presented in various sources are significantly different, selection of spectroscopic data for these elements (particularly oscillator strength) was expected to be useful for plasma diagnostics. The Boltzmann plot method was used as a tool for the selection of appropriate spectral lines and their spectroscopic data. The main result of the paper is W I, Mo I and Cr I spectral lines and spectroscopic data recommended for diagnostics of plasma with such metal impurities.

  6. Cyclic trinuclear copper(I), silver(I), and gold(I) complexes: a theoretical insight.

    PubMed

    Caramori, Giovanni F; Piccoli, Rafael M; Segala, Maximiliano; Muñoz-Castro, Alvaro; Guajardo-Maturana, Raul; Andrada, Diego M; Frenking, Gernot

    2015-01-01

    The metal-ligand, M-L, bonding situation in cyclic trinuclear complexes, CTCs, of copper(I), silver(I), and gold(I) was investigated in terms of the energy decomposition analysis (EDA-NOCV) and natural bond orbitals (NBOs). The anisotropy of the induced current density (ACID) and magnetic response were employed to evaluate the effect of electronic conjugation and metal-metal interactions in CTCs. The EDA-NOCV results show that the M-L bonding is stronger in gold(I) than in copper(I) or silver(I) complexes. Au(+)-L bonds present an elevated covalent character when compared with Cu(+)-L and Ag(+)-L bonds. The NBO analysis confirms the elevated covalent character observed for Au(+)-L bonds, indicating that the ligand-metal donation, L → M, and the metal-ligand back-donation, M → L, are more stabilizing in gold(I) than in copper(I) or silver(I) complexes. Both ACID and the magnetic response calculations reveal that there are cyclic conjugations in the ligands and a strong diatropic ring current indicating the presence of aromaticity. However, there is no through-bond M-L conjugation between the ligands and the metallic centers, as indicated by the absence of a continuous anisotropy boundary surface involving M-L bonds. PMID:25385159

  7. iNACOL Research Agenda

    ERIC Educational Resources Information Center

    International Association for K-12 Online Learning, 2013

    2013-01-01

    The International Association for K-12 Online Learning (iNACOL) publishes a research agenda on an ongoing basis to continue its work in field-building, capacity-building and knowledge-building. Based on a 2013 survey of the field to identify research needs, iNACOL developed a research approach, including the following: (1) Build a collaborative…

  8. GREEK BASIC COURSE, VOLUME I.

    ERIC Educational Resources Information Center

    OBOLENSKY, SERGE; AND OTHERS

    THE GREEK LANGUAGE DESCRIBED IN VOLUME I OF THIS INTRODUCTORY COURSE FOR ADULTS IS THE "KATHOMILUMENI" VARIETY, THAT OF THE STANDARD SPEECH OF EDUCATED GREEKS. (VOLUME III OF THE COURSE INTRODUCES THE MORE FORMAL KATHAREVUSA VARIETY.) EACH VOLUME OF THE COURSE CONTAINS 25 UNITS PLUS FIVE REVIEW SECTIONS. A TYPICAL UNIT IN VOLUME I CONSISTS OF--(1)…

  9. Why Am I So Sad?

    MedlinePlus

    ... Chloe & Nurb Meet The Brain (Movie) Quiz: Do You Need a Flu Shot? Got Homework? Here's Help White House Lunch Recipes Why Am I So Sad? KidsHealth > For Kids > Why Am I So Sad? ... Do Kids Feel Sad About? Are Sad Feelings Normal? How Can You Deal With Sad Feelings? en español ¿Por qué ...

  10. Seeing I to I: A Pathway to Interpersonal Connectedness

    PubMed Central

    Pinel, Elizabeth C.; Long, Anson E.; Landau, Mark J.; Alexander, Kira; Pyszczynski, Tom

    2009-01-01

    The authors introduce the construct of I-sharing—the belief that one shares an identical subjective experience with another person—and the role it plays in liking. In Studies 1–3, participants indicated their liking for an objectively similar and an objectively dissimilar person, one of whom I-shared with them and the other of whom did not. Participants preferred the objectively similar person but only when that person I-shared with them. Studies 4 and 5 highlight the role that feelings of existential isolation and the need for closeness play in people’s attraction to I-sharers. In Study 4, people with high needs for interpersonal closeness responded to I-sharers and non-I-sharers with great intensity. In Study 5, priming participants with feelings of existential isolation increased their liking for I-sharers over objectively similar others. The results highlight the importance of shared subjective experience and have implications for interpersonal and intergroup processes. PMID:16536649

  11. Li I AND K I SCATTER IN COOL PLEIADES DWARFS

    SciTech Connect

    King, Jeremy R.; Schuler, Simon C.; Hobbs, L. M.; Pinsonneault, Marc H. E-mail: sschuler@noao.ed E-mail: pinsono@astronomy.ohio-state.ed

    2010-02-20

    We utilize high-resolution (R {approx} 60,000), high signal-to-noise ratio ({approx}100) spectroscopy of 17 cool Pleiades dwarfs to examine the confounding star-to-star scatter in the lambda6707 Li I line strengths in this young cluster. Our Pleiades, selected for their small projected rotational velocity and modest chromospheric emission, evince substantial scatter in the line strengths of lambda6707 Li I feature that is absent in the lambda7699 K I resonance line. The Li I scatter is not correlated with that in the high-excitation lambda7774 O I feature, and the magnitude of the former is greater than the latter despite the larger temperature sensitivity of the O I feature. These results suggest that systematic errors in line strength measurements due to blending, color (or color-based T{sub eff}) errors, or line formation effects related to an overlying chromosphere are not the principal source of Li I scatter in our stars. There do exist analytic spot models that can produce, via line formation effects, the observed Li scatter without introducing scatter in the K I line strengths or the color-magnitude diagram. However, these models predict factor of >=3 differences in abundances derived from the subordinate lambda6104 and resonance lambda6707 Li I features; we find no difference in the abundances determined from these two features. These analytic spot models also predict CN line strengths significantly larger than we observe in our spectra. The simplest explanation of the Li, K, CN, and photometric data is that there must be a real abundance component to the Pleiades Li dispersion. We suggest that this real abundance component is the manifestation of relic differences in erstwhile pre-main-sequence Li burning caused by effects of surface activity on stellar structure. We discuss observational predictions of these effects, which may be related to other anomalous stellar phenomena.

  12. Observing with HST I: A New Phase I Proposal Process

    NASA Astrophysics Data System (ADS)

    Mutchler, Max; Anderson, Ken; Asson, Drew; Downes, Ron; Lucas, Ray; Madau, Piero; Payne, Harry

    1994-05-01

    The Hubble Space Telescope (HST) proposal process occurs in two phases. In Phase I, proposers create and submit proposals which emphasize scientific justification and HST resource requirements. These proposals go through a two-stage external scientific peer review. Successful proposers must then prepare a more detailed Phase II proposal for implementation. The next round (Cycle 5) of HST observing is expected to start in mid-1995, and the call for Phase I proposals for this round is expected to be sent out 1 June 1994 with a proposal submission deadline of 15 August 1994. For Cycle 5, STScI is introducing some major simplifications and improvements into the Phase I process which will be described in this paper. Among these changes are a switch from spacecraft time to orbits as the basis for resource allocation and accounting, and the introduction of a LaTex template for proposal preparation. New instructions for estimating the required number of orbits have been developed that are accurate and easy to use. The LaTex template serves two purposes: from it the proposer can print the hardcopy of the proposal for submission; in addition the completed template is to be sent electronically to STScI where it will be used to populate the proposal tracking database. In this Cycle, STScI will also experiment on a limited basis with all-electronic proposal submission as a step towards what will hopefully become a more ``paperless'' process in the future.

  13. Draft genome sequences of four <i>Streptomyces> isolates from the <i>Populus trichocarpai> root endosphere and rhizosphere

    SciTech Connect

    Klingeman, Dawn M.; Utturkar, Sagar; Lu, Tse -Yuan S.; Schadt, Christopher W.; Pelletier, Dale A.; Brown, Steve D.

    2015-11-12

    Draft genome sequences for four Actinobacteria from the genus <i>Streptomyces> are presented. <i>Streptomyces> is a metabolically diverse genus that is abundant in soils and has been reported in association with plants. The strains described in this study were isolated from the <i>Populus trichocarpai> endosphere and rhizosphere.

  14. Genome sequence and annotation of <i>Trichoderma parareeseii>, the ancestor of the cellulase producer <i>Trichoderma reeseii>

    SciTech Connect

    Yang, Dongqing; Pomraning, Kyle; Kopchinskiy, Alexey; Karimi, Aghcheh Razieh; Atanasova, Lea; Chenthamara, Komal; Baker, Scott E.; Zhang, Ruifu; Shen, Qirong; Freitag, Michael; Kubicek, Christian P.; Druzhinina, Irina S.

    2015-08-13

    The filamentous fungus <i>Trichoderma parareeseii> is the asexually reproducing ancestor of <i>Trichoderma reeseii>, the holomorphic industrial producer of cellulase and hemicellulase. Here, we present the genome sequence of the <i>T. parareeseii> type strain CBS 125925, which contains genes for 9,318 proteins.

  15. 'Ppl, I Have Breast Cancer'

    MedlinePlus

    ... gov/news/fullstory_160134.html 'Ppl, I Have Breast Cancer' Many women found online support after their diagnosis, ... Women who communicated via social media after a breast cancer diagnosis and received information and/or support about ...

  16. Rockets in World War I

    NASA Technical Reports Server (NTRS)

    2004-01-01

    World War I enlisted rockets once again for military purposes. French pilots rigged rockets to the wing struts of their airplanes and aimed them at enemy observation balloons filled with highly inflammable hydrogen.

  17. NHEXAS PHASE I MARYLAND STUDY

    EPA Science Inventory

    The National Human Exposure Assessment Survey (NHEXAS) is a federal interagency research effort coordinated by the Environmental Protection Agency (EPA), Office of Research and Development (ORD). Phase I consists of demonstration/scoping studies using probability-based sampling ...

  18. NHEXAS PHASE I ARIZONA STUDY

    EPA Science Inventory

    The National Human Exposure Assessment Survey (NHEXAS) is a federal interagency research effort coordinated by the Environmental Protection Agency (EPA), Office of Research and Development (ORD). The objective of the NHEXAS Phase I Arizona study was to determine the distribution...

  19. Total Synthesis of Solandelactone I.

    PubMed

    Eichenauer, Nils C; Tschersich, Roxanne; Pietruszka, Jörg

    2015-11-25

    Since the marine natural products solandelactones A-I were isolated from the hydroid Solanderia secunda and investigated by Seo et al. in 1996, considerable synthetic efforts toward these marine oxylipins followed. However, the structure elucidation of solandelactone I remained incomplete, and no synthesis has been reported. On the basis of our retrosynthetic analysis, the key building blocks were combined in a Horner-Wadsworth-Emmons reaction to create two common intermediates for the stereodivergent synthesis of all four diastereomers 1-4 matching the proposed structure of solandelactone I. Comparison of the published analytical data of natural product solandelactone I and data obtained from the synthetic endeavor toward diastereomers 1-4 enabled the structure assignment of isomer 3; the proposed biosynthetic pathway for marine oxylipins also supports the result. PMID:26562358

  20. Teaching with iPads

    NASA Astrophysics Data System (ADS)

    Maj, Hubert

    2015-04-01

    Bilingual students in high school with bilingual units in Boguchwała have received iPads for learning English and a few subjects using CLIL (biology, basics of entrepreneurship, geography, IT and mathematics). Lessons with iPads are interesting for students for several reasons. First of all, teenagers like new technologies and using iPads for teaching helps students to learn by fun. Secondly, iPads give new possibilities of looking for knowledge about each theme. Moreover, teaching with iPads develops students' engagement. They have a chance to choose a few among over 65 000 applications for gathering and then presenting information about the lesson topic. They can easily prepare presentations, movies, cartoons, mind maps or whatever they like. Teaching students, thanks to the iPads, makes it their initiative, and the teacher can inspire them to look for the knowledge rather than disciplining pupils. But teaching with iPads is connected with many problems. For instance, there are not any examples on how to teach using these tools. It is very up-to-date technology and teachers firstly must learn the possibilities of iPads and look for new applications. It takes much time, especially at the beginning, and is difficult especially for inexperienced teachers. In addition, it is almost impossible to maintain control of the iPads for all of the students during the lesson. They can use their iPads for something unconnected with the topic of the lesson. Thirdly is lack of time - active methods (with iPads as well) are more time-consuming and it could be that they do not finish the whole program. And of course the last, but not at least, is the problem of money. Some of the applications must be paid for, and it is usually obligatory to possess a credit card. Fortunately, it is not expensive - applications usually cost a few euros and many of them are free and really good.

  1. Graphs for 53-I (Iodine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume A `Nuclei with Z = 1 - 54' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms'. It provides a graphic representation of nucleon separation energies and residual interaction parameters for isotopes of the chemical element 53-I (Iodine, atomic number Z = 53).

  2. ApoA-I mimetics.

    PubMed

    Stoekenbroek, R M; Stroes, E S; Hovingh, G K

    2015-01-01

    A wealth of evidence indicates that plasma levels of high-density lipoprotein cholesterol (HDL-C) are inversely related to the risk of cardiovascular disease (CVD). Consequently, HDL-C has been considered a target for therapy in order to reduce the residual CVD burden that remains significant, even after application of current state-of-the-art medical interventions. In recent years, however, a number of clinical trials of therapeutic strategies that increase HDL-C levels failed to show the anticipated beneficial effect on CVD outcomes. As a result, attention has begun to shift toward strategies to improve HDL functionality, rather than levels of HDL-C per se. ApoA-I, the major protein component of HDL, is considered to play an important role in many of the antiatherogenic functions of HDL, most notably reverse cholesterol transport (RCT), and several therapies have been developed to mimic apoA-I function, including administration of apoA-I, mutated variants of apoA-I, and apoA-I mimetic peptides. Based on the potential anti-inflammatory effects, apoA-I mimetics hold promise not only as anti-atherosclerotic therapy but also in other therapeutic areas. PMID:25523005

  3. 40 CFR Table I-6 to Subpart I - Table I-6 to Subpart I of Part 98-Table I-6 to Subpart I of Part 98-Default Emission Factors (1...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS...-Table I-6 to Subpart I of Part 98-Default Emission Factors (1-Uij) for Gas Utilization Rates (Uij) and... I of Part 98-Table I-6 to Subpart I of Part 98—Default Emission Factors (1-Uij) for Gas...

  4. 40 CFR Table I-7 to Subpart I - Table I-7 to Subpart I of Part 98-Table I-7 to Subpart I of Part 98-Default Emission Factors (1...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS...-Table I-7 to Subpart I of Part 98-Default Emission Factors (1-Uij) for Gas Utilization Rates (Uij) and... I of Part 98-Table I-7 to Subpart I of Part 98—Default Emission Factors (1-Uij) for Gas...

  5. [Type I interferonopathies].

    PubMed

    Munoz, J; Marque, M; Dandurand, M; Meunier, L; Crow, Y-J; Bessis, D

    2015-11-01

    Type I interferonopathies are a group of Mendelian disorders characterized by a common physiopathology: the up-regulation of type I interferons. To date, interferonopathies include Aicardi-Goutières syndrome, familial chilblain lupus, spondyenchondromatosis, PRoteasome-associated auto-inflammatory syndrome (PRAAS) and Singleton-Merten syndrome. These diseases present phenotypic overlap including cutaneous features like chilblain lupus, that can be inaugural or present within the first months of life. This novel set of inborn errors of immunity is evolving rapidly, with recognition of new diseases and genes. Recent and improved understanding of the physiopathology of overexpression of type I interferons has allowed the development of targeted therapies, currently being evaluated, like Janus-kinases or reverse transcriptase inhibitors. PMID:26363997

  6. Radiative lifetimes in Co I

    NASA Astrophysics Data System (ADS)

    Nitz, D. E.; Bergeson, S. D.; Lawler, J. E.

    1995-03-01

    New radiative-lifetime measurements based on time-resolved laser-induced fluorescence are reported for 133 odd-parity and 2 even-parity levels of Co I, ranging in energy from 28300 to 59400 cm-1. Our lifetimes agree with earlier, but much less extensive, lifetime measurements based on laser-induced fluorescence. Satisfactory agreement is also found with the critical compilation of atomic transition probabilities from the U.S. National Bureau of Standards [J. Phys. Chem. Ref. Data 17, Suppl 4 (1988)]. Our measurements provide a reliable absolute normalization for a much more comprehensive determination of Co I atomic transition probabilities.

  7. How I Became an Astronomer

    NASA Technical Reports Server (NTRS)

    Maran, Stephen P.

    2001-01-01

    Life as an astronomer has taken me to view eclipses of the Sun from the Gaspe' Peninsula to the Pacific Ocean and the China and Coral Seas, and to observe the stars at observatories across the USA and as far south as Chile. I've also enjoyed working with NASA's telescopes in space, including the Hubble Space Telescope and the International Ultraviolet Explorer. It seems funny to reflect that it all began in the Sixth Grade by a fluke - the consequence of a hoax letter whose author I never identified.

  8. ARIES-I tritium system

    SciTech Connect

    Sze, D.K.; Tam, S.W.; Billone, M.C.; Hassanein, A.M. ); Martin, R. )

    1990-09-01

    A key safety concern in a D-T fusion reactor is the tritium inventory. There are three components in a fusion reactor with potentially large inventories, i.e., the blanket, the fuel processing system and the plasma facing components. The ARIES team selected the material combinations, decided the operating conditions and refined the processing systems, with the aiming of minimizing the tritium inventories and leakage. The total tritium inventory for the ARIES-I reactor is only 700 g. This paper discussed the calculations and assumptions we made for the low tritium inventory. We also addressed the uncertainties about the tritium inventory. 13 refs., 2 figs., 3 tabs.

  9. Saturn I (SA-4) Launch

    NASA Technical Reports Server (NTRS)

    1963-01-01

    The Saturn I (SA-4) flight lifted off from Kennedy Space Center launch Complex 34, March 28, 1963. The fourth launch of Saturn launch vehicles developed at the Marshall Space Flight Center (MSFC), under the direction of Dr. Wernher von Braun, incorporated a Saturn I, Block I engine. The typical height of a Block I vehicle was approximately 163 feet and had only one live stage. It consisted of eight tanks, each 70 inches in diameter, clustered around a central tank, 105 inches in diameter. Four of the external tanks were fuel tanks for the RP-1 (kerosene) fuel. The other four, spaced alternately with the fuel tanks, were liquid oxygen tanks as was the large center tank. All fuel tanks and liquid oxygen tanks drained at the same rates respectively. The thrust for the stage came from eight H-1 engines, each producing a thrust of 165,000 pounds, for a total thrust of over 1,300,000 pounds. The engines were arranged in a double pattern. Four engines, located inboard, were fixed in a square pattern around the stage axis and canted outward slightly, while the remaining four engines were located outboard in a larger square pattern offset 40 degrees from the inner pattern. Unlike the inner engines, each outer engine was gimbaled. That is, each could be swung through an arc. They were gimbaled as a means of steering the rocket, by letting the instrumentation of the rocket correct any deviations of its powered trajectory. The block I required engine gimabling as the only method of guiding and stabilizing the rocket through the lower atmosphere. The upper stages of the Block I rocket reflected the three-stage configuration of the Saturn I vehicle. Like SA-3, the SA-4 flight's upper stage ejected 113,560 liters (30,000 gallons) of ballast water in the upper atmosphere for 'Project Highwater' physics experiment. Release of this vast quantity of water in a near-space environment marked the second purely scientific large-scale experiment. The SA-4 was the last Block I rocket

  10. Saturn I (SA-4) Launch

    NASA Technical Reports Server (NTRS)

    1963-01-01

    The Saturn I (SA-4) flight lifted off from Kennedy Space Center launch Complex 34, March 28, 1963. The fourth launch of Saturn launch vehicles, developed at the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun, incorporated a Saturn I, Block I engine. The typical height of a Block I vehicle was approximately 163 feet and had only one live stage. It consisted of eight tanks, each 70 inches in diameter, clustered around a central tank, 105 inches in diameter. Four of the external tanks were fuel tanks for the RP-1 (kerosene) fuel. The other four, spaced alternately with the fuel tanks, were liquid oxygen tanks as was the large center tank. All fuel tanks and liquid oxygen tanks drained at the same rates respectively. The thrust for the stage came from eight H-1 engines, each producing a thrust of 165,000 pounds, for a total thrust of over 1,300,000 pounds. The engines were arranged in a double pattern. Four engines, located inboard, were fixed in a square pattern around the stage axis and canted outward slightly, while the remaining four engines were located outboard in a larger square pattern offset 40 degrees from the inner pattern. Unlike the inner engines, each outer engine was gimbaled. That is, each could be swung through an arc. They were gimbaled as a means of steering the rocket, by letting the instrumentation of the rocket correct any deviations of its powered trajectory. The block I required engine gimabling as the only method of guiding and stabilizing the rocket through the lower atmosphere. The upper stages of the Block I rocket reflected the three-stage configuration of the Saturn I vehicle. Like SA-3, the SA-4 flight's upper stage ejected 113,560 liters (30,000 gallons) of ballast water in the upper atmosphere for 'Project Highwater' physics experiment. Release of this vast quantity of water in a near-space environment marked the second purely scientific large-scale experiment. The SA-4 was the last Block I rocket

  11. Models for Type I supernovae

    SciTech Connect

    Woosley, S.E.; Weaver, T.A.; Taam, R.E.

    1980-06-17

    Two rather disjoint scenarios for Type I supernovae are presented. One is based upon mass accretion by a white dwarf in a binary system. The second involves a star having some 8 to 10 times the mass of the sun which may or may not be a solitary star. Despite the apparent dissimilarities in the models it may be that each occurs to some extent in nature for they both share the possibility of producing substantial quantities of /sup 56/Ni and explosions in stars devoid of hydrogen envelopes. These are believed to be two properties that must be shared by any viable Type I model.

  12. 76 FR 25364 - Agency Information Collection Activities: Form I-864, Form I-864A, Form I-864EZ, and From I-864W...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-864, Form I- 864A, Form I-864EZ, and From I-864W; Extension of an Existing Information Collection; Comment Request. ACTION: 60-Day Notice of Information Collection Under Review; Form I- 864, Affidavit of...

  13. 75 FR 26782 - Agency Information Collection Activities: Form I-864, Form I-864A, Form I-864EZ, and Form I-864W...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-864, Form I- 864A, Form I-864EZ, and Form I-864W; Extension of an Existing Information Collection; Comment Request ACTION: 60-Day Notice of Information Collection Under Review; Form I- 864, Affidavit of...

  14. NHT-1 I/O Benchmarks

    NASA Technical Reports Server (NTRS)

    Carter, Russell; Ciotti, Bob; Fineberg, Sam; Nitzbert, Bill

    1992-01-01

    The NHT-1 benchmarks am a set of three scalable I/0 benchmarks suitable for evaluating the I/0 subsystems of high performance distributed memory computer systems. The benchmarks test application I/0, maximum sustained disk I/0, and maximum sustained network I/0. Sample codes are available which implement the benchmarks.

  15. The Meganuclease I-SceI Containing Nuclear Localization Signal (NLS-I-SceI) Efficiently Mediated Mammalian Germline Transgenesis via Embryo Cytoplasmic Microinjection

    PubMed Central

    Xiang, Peng-Ying; Wang, Lu-Lu; Tang, Huan; Xie, Fei; Li, Liang; Wei, Hong

    2014-01-01

    The meganuclease I-SceI has been effectively used to facilitate transgenesis in fish eggs for nearly a decade. I-SceI-mediated transgenesis is simply via embryo cytoplasmic microinjection and only involves plasmid vectors containing I-SceI recognition sequences, therefore regarding the transgenesis process and application of resulted transgenic organisms, I-SceI-mediated transgenesis is of minimal bio-safety concerns. However, currently no transgenic mammals derived from I-SceI-mediated transgenesis have been reported. In this work, we found that the native I-SceI molecule was not capable of facilitating transgenesis in mammalian embryos via cytoplasmic microinjection as it did in fish eggs. In contrast, the I-SceI molecule containing mammalian nuclear localization signal (NLS-I-SceI) was shown to be capable of transferring DNA fragments from cytoplasm into nuclear in porcine embryos, and cytoplasmic microinjection with NLS-I-SceI mRNA and circular I-SceI recognition sequence-containing transgene plasmids resulted in transgene expression in both mouse and porcine embryos. Besides, transfer of the cytoplasmically microinjected mouse and porcine embryos into synchronized recipient females both efficiently resulted in transgenic founders with germline transmission competence. These results provided a novel method to facilitate mammalian transgenesis using I-SceI, and using the NLS-I-SceI molecule, a simple, efficient and species-neutral transgenesis technology based on embryo cytoplasmic microinjection with minimal bio-safety concerns can be established for mammalian species. As far as we know, this is the first report for transgenic mammals derived from I-SceI-mediated transgenesis via embryo cytoplasmic microinjection. PMID:25250567

  16. H I SHELLS AND SUPERSHELLS IN THE I-GALFA H I 21 cm LINE SURVEY. I. FAST-EXPANDING H I SHELLS ASSOCIATED WITH SUPERNOVA REMNANTS

    SciTech Connect

    Park, G.; Koo, B.-C.; Gibson, S. J.; Newton, J. H.; Kang, J.-H.; Lane, D. C.; Douglas, K. A.; Peek, J. E. G.; Korpela, E. J.; Heiles, C.

    2013-11-01

    We search for fast-expanding H I shells associated with Galactic supernova remnants (SNRs) in the longitude range l ≈ 32° to 77° using 21 cm line data from the Inner-Galaxy Arecibo L-band Feed Array (I-GALFA) H I survey. Among the 39 known Galactic SNRs in this region, we find such H I shells in 4 SNRs: W44, G54.4-0.3, W51C, and CTB 80. All four were previously identified in low-resolution surveys, and three of those (excluding G54.4-0.3) were previously studied with the Arecibo telescope. A remarkable new result, however, is the detection of H I emission at both very high positive and negative velocities in W44 from the receding and approaching parts of the H I expanding shell, respectively. This is the first detection of both sides of an expanding shell associated with an SNR in H I 21 cm emission. The high-resolution I-GALFA survey data also reveal a prominent expanding H I shell with high circular symmetry associated with G54.4-0.3. We explore the physical characteristics of four SNRs and discuss what differentiates them from other SNRs in the survey area. We conclude that these four SNRs are likely the remnants of core-collapse supernovae interacting with a relatively dense (∼> 1 cm{sup –3}) ambient medium, and we discuss the visibility of SNRs in the H I 21 cm line.

  17. 30 CFR 57.22217 - Seals and stoppings (I-A, I-B, and I-C mines).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Seals and stoppings (I-A, I-B, and I-C mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22217 Seals and stoppings (I-A, I-B, and I-C mines). All seals, and those stoppings that separate main intake from...

  18. 30 CFR 57.22217 - Seals and stoppings (I-A, I-B, and I-C mines).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Seals and stoppings (I-A, I-B, and I-C mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22217 Seals and stoppings (I-A, I-B, and I-C mines). All seals, and those stoppings that separate main intake from...

  19. 30 CFR 57.22217 - Seals and stoppings (I-A, I-B, and I-C mines).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Seals and stoppings (I-A, I-B, and I-C mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22217 Seals and stoppings (I-A, I-B, and I-C mines). All seals, and those stoppings that separate main intake from...

  20. 30 CFR 57.22217 - Seals and stoppings (I-A, I-B, and I-C mines).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Seals and stoppings (I-A, I-B, and I-C mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22217 Seals and stoppings (I-A, I-B, and I-C mines). All seals, and those stoppings that separate main intake from...

  1. 30 CFR 57.22217 - Seals and stoppings (I-A, I-B, and I-C mines).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Seals and stoppings (I-A, I-B, and I-C mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22217 Seals and stoppings (I-A, I-B, and I-C mines). All seals, and those stoppings that separate main intake from...

  2. Korean Basic Course. Volume I.

    ERIC Educational Resources Information Center

    Park, B. Nam

    Volume I of the Korean Basic Course provides introductory materials for the student who wishes to achieve a working command of the language currently spoken by an estimated 40 to 43 million people on the Korean Peninsula and in Japan, Manchuria, and the Soviet Union. The linguistic content is based on the speech of educated Koreans in Seoul, the…

  3. Ares I Stage Separation Test

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. In this HD video image, an Ares I x-test involves the upper stage separating from the first stage. This particular test was conducted at the NASA Langley Research Center in July 2007. (Highest resolution available)

  4. Wastewater Treatment I. Instructor's Manual.

    ERIC Educational Resources Information Center

    California Water Pollution Control Association, Sacramento. Joint Education Committee.

    This instructor's manual provides an outline and guide for teaching Wastewater Treatment I. It consists of nine sections. An introductory note and a course outline comprise sections 1 and 2. Section 3 (the bulk of the guide) presents lesson outlines for teaching the ten chapters of the manual entitled "Operation of Wastewater Treatment Plants."…

  5. Fire Officer I Lesson Plans.

    ERIC Educational Resources Information Center

    Pribyl, Paul F.

    Lesson plans are provided for the Fire Officer I course. Material for each lesson is presented in this format: course title, lesson title, equipment required, training aids needed, and a content outline which details teaching points and related instructor references. These references, or suggested readings, are listed at the conclusion of each…

  6. Teaching the iGeneration

    ERIC Educational Resources Information Center

    Rosen, Larry D.

    2011-01-01

    Children and teens today are immersed in technology. Just as we don't think about the existence of air, they don't think about technology and media. Individualized mobile devices have given them the expectation that if they conceive of something, they will be able to make it happen. Yet schools still expect these members of the iGeneration to…

  7. Aerospace Environment. Aerospace Education I.

    ERIC Educational Resources Information Center

    Savler, D. S.; Smith, J. C.

    This book is one in the series on Aerospace Education I. It briefly reviews current knowledge of the universe, the earth and its life-supporting atmosphere, and the arrangement of celestial bodies in outer space and their physical characteristics. Chapter 1 includes a brief survey of the aerospace environment. Chapters 2 and 3 examine the…

  8. Community Living Skills: Nutrition I.

    ERIC Educational Resources Information Center

    Kreps, Alice Roelofs; Dreith, Rita Vallero

    One of twenty course guides in the Community Living Skills Guide for the College for Living series, this document provides guidelines and workbook activities for the course, Nutrition I. The series of courses for developmentally disabled adults is intended to supplement residential programs and to aid in orienting institutionalized persons to…

  9. IPNS-I chopper spectrometers

    SciTech Connect

    Price, D.L.; Carpenter, J.M.; Pelizzari, C.A.; Sinha, S.K.; Bresof, I.; Ostrowski, G.E.

    1982-01-01

    We briefly describe the layout and operation of the two chopper experiments at IPNS-I. The recent measurement on solid /sup 4/He by Hilleke et al. provides examples of time-of-flight data from the Low Resolution Chopper Spectrometer.

  10. Iowa and World War I.

    ERIC Educational Resources Information Center

    Hardesty, Carolyn, Ed.

    1989-01-01

    This issue of the children's quarterly magazine, "The Goldfinch," focuses on World War I. A brief discussion of how the United States came to enter the War is followed by a discussion of propaganda. An article on the use of posters to encourage citizens to participate in the war effort is illustrated with reproductions of several of these posters.…

  11. Theatre I & II Instructional Guide.

    ERIC Educational Resources Information Center

    Montgomery County Public Schools, Rockville, MD.

    By taking a two-semester course in theatre, students in grades 10 through 12 can gain a better understanding of drama. Theatre I provides an overview of the field of theatre and serves as a prerequisite to all further theatre courses. Upon completion of the first course, students should be able to (1) respond aesthetically to theatre; (2)…

  12. I'm like ... Professional

    ERIC Educational Resources Information Center

    Kyburz, Bonnie

    2010-01-01

    "Given that my film is exploring a punk ethos that attends DIY filmmaking, I decided that the rough nature of the video created appropriate content... these are the sorts of details that reveal the complex, cinema verite nature of the DIY experience."

  13. Aerospace Community. Aerospace Education I.

    ERIC Educational Resources Information Center

    Mickey, V. V.

    This book, one in the series on Aerospace Education I, emphasizes the two sides of aerospace--military aerospace and civilian aerospace. Chapter 1 includes a brief discussion on the organization of Air Force bases and missile sites in relation to their missions. Chapter 2 examines the community services provided by Air Force bases. The topics…

  14. Quenched! The ISABELLE Saga, I

    NASA Astrophysics Data System (ADS)

    Crease, Robert P.

    2005-09-01

    The story of ISABELLE, a colliding-beam accelerator conceived in 1971, officially approved in 1978, partially constructed, and terminated in 1983, is an important episode in the history of post-World War II science in the United States.The events surrounding its planning, construction, and termination reveal much about the ambitions, strategies, and tensions of American high-energy physicists, their collaborations and rivalries, and the difficulties of funding and constructing a large scientific facility in the age of Big Science. In this article, the first of two parts, I cover the period up to the beginning of construction in 1978. I place ISABELLE in the context of the early history of colliders, outline the physics goals that motivated the machine, and describe the research and motivations behind its innovative but ultimately problematic superconducting magnet design. I cover the key technological and administrative steps that the laboratory took to get the project underway and steer it past several review committees. I also treat some of the conflicts within the laboratory, and between Brookhaven and other laboratories, especially Fermilab, that hampered the project.

  15. Tetraphenylphosphonium copper(I) dicyanamide.

    SciTech Connect

    Schlueter, J. A.; Geiser, U.; Materials Science Division

    2007-01-01

    In the title compound, {l_brace}(C{sub 24}H{sub 20}P)[Cu(C{sub 2}N{sub 3}){sub 2}]{r_brace}{sub n}, the copper(I) dicyanamide anion forms a distorted three-dimensional single diamondoid network. Templating tetraphenylphosphonium cations reside within the cavities of the polymeric anion.

  16. An iPad Education?

    ERIC Educational Resources Information Center

    Cooper, Kenneth J.

    2012-01-01

    In keeping with Steve Jobs' vision of transforming education, Apple has expanded its iTunes U so that professors can offer entire courses, not just lectures. So far, though, colleges and universities are not rushing to drop the platforms they use for online learning and adopt the new application from the technology heavyweight. Apple bills the…

  17. Being an iPadist

    ERIC Educational Resources Information Center

    Randles, Clint

    2013-01-01

    This column offers the personal reflections of the author on being a member of the band Touch, an iPad performing ensemble composed of music education faculty members and doctoral students at the University of South Florida. The ensemble primarily performed its own arrangements of popular music selections from a number of genres including, but not…

  18. Ares I First Stage Progress

    NASA Technical Reports Server (NTRS)

    Brasfield, Fred

    2009-01-01

    Building on the legacy of the Space Shuttle and other NASA space exploration initiatives, the propulsion for the Ares I First Stage will be a Shuttle derived reusable solid rocket motor. Significant progress has been made to date by the Ares First Stage Team. This brief status provides an update on the design and development of the Ares First Stage propulsion system.

  19. Saturn I (SA-3) Launch

    NASA Technical Reports Server (NTRS)

    1962-01-01

    The Saturn I (SA-3) flight lifted off from Kennedy Space Center launch Complex 34, November 16, 1962. The third launch of Saturn launch vehicles, developed at the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun, incorporated a Saturn I, Block I engine. The typical height of a Block I vehicle was approximately 163 feet. and had only one live stage. It consisted of eight tanks, each 70 inches in diameter, clustered around a central tank, 105 inches in diameter. Four of the external tanks were fuel tanks for the RP-1 (kerosene) fuel. The other four, spaced alternately with the fuel tanks, were liquid oxygen tanks as was the large center tank. All fuel tanks and liquid oxygen tanks drained at the same rates respectively. The thrust for the stage came from eight H-1 engines, each producing a thrust of 165,000 pounds, for a total thrust of over 1,300,000 pounds. The engines were arranged in a double pattern. Four engines, located inboard, were fixed in a square pattern around the stage axis and canted outward slightly, while the remaining four engines were located outboard in a larger square pattern offset 40 degrees from the inner pattern. Unlike the inner engines, each outer engine was gimbaled. That is, each could be swung through an arc. They were gimbaled as a means of steering the rocket, by letting the instrumentation of the rocket correct any deviations of its powered trajectory. The block I required engine gimabling as the only method of guiding and stabilizing the rocket through the lower atmosphere. The upper stages of the Block I rocket reflected the three-stage configuration of the Saturn I vehicle. During the SA-3 flight, the upper stage ejected 113,560 liters (30,000 gallons) of ballast water in the upper atmosphere for 'Project Highwater' physics experiment. The water was released at an altitude of 65 miles, where within only 5 seconds, it expanded into a massive ice cloud 4.6 miles in diameter. Release of this vast

  20. Vibrational spectroscopy of photosystem I.

    PubMed

    Hastings, Gary

    2015-01-01

    Fourier transform infrared difference spectroscopy (FTIR DS) has been widely used to study the structural details of electron transfer cofactors (and their binding sites) in many types of photosynthetic protein complexes. This review focuses in particular on work that has been done to investigate the A₁cofactor in photosystem I photosynthetic reaction centers. A review of this subject area last appeared in 2006 [1], so only work undertaken since then will be covered here. Following light excitation of intact photosystem I particles the P700⁺A⁻(1) secondary radical pair state is formed within 100ps. This state decays within 300ns at room temperature, or 300μs at 77K. Given the short-lived nature of this state, it is not easily studied using "static" photo-accumulation FTIR difference techniques at either temperature. Time-resolved techniques are required. This article focuses on the use of time-resolved step-scan FTIR DS for the study of the P700⁺A⁻(1) state in intact photosystem I. Up until now, only our group has undertaken studies in this area. So, in this article, recent work undertaken in our lab is described, where we have used low-temperature (77K), microsecond time-resolved step-scan FTIR DS to study the P700⁺A⁻(1) state in photosystem I. In photosystem I a phylloquinone molecule occupies the A₁binding site. However, different quinones can be incorporated into the A1 binding site, and here work is described for photosystem I particles with plastoquinone-9, 2-phytyl naphthoquinone and 2-methyl naphthoquinone incorporated into the A₁binding site. Studies in which ¹⁸O isotope labeled phylloquinone has been incorporated into the A1 binding site are also discussed. To fully characterize PSI particles with different quinones incorporated into the A1 binding site nanosecond to millisecond visible absorption spectroscopy has been shown to be of considerable value, especially so when undertaken using identical samples under identical conditions

  1. FIRE I - Marine Stratocumulus Data Sets

    Atmospheric Science Data Center

    2013-07-12

    FIRE I - Marine Stratocumulus Data Sets First ISCCP Regional Experiment (FIRE) I - Marine Stratocumulus was conducted off the southwestern coast of California. ... FIRE Project Guide FIRE I - Marine Stratocumulus Home Page SCAR-B Block:  ...

  2. FIRE I - Extended Time Observations Data Sets

    Atmospheric Science Data Center

    2013-08-01

    FIRE I - Extended Time Observations Data Sets First ISCCP Regional Experiment (FIRE) I - Extended Time Observations were conducted in Utah. Relevant Documents:  FIRE Project Guide FIRE I - Extended Time Observations Home Page SCAR-B Block:  ...

  3. Health Occupations Education I. Module No. I-A to I-G.

    ERIC Educational Resources Information Center

    Dunmeyer, Kathryn; And Others

    This set of 7 modules on medical and surgical asepsis is 1 of 11 sets in the Health Occupations Education I instructional package for the first year of a 2-year course of study. The materials are designed to prepare students through individualized instruction for entry-level job opportunities on health care teams in a variety of practice settings.…

  4. A Wolter type I LAMAR

    NASA Technical Reports Server (NTRS)

    Catura, R. C.; Joki, E. G.

    1981-01-01

    Observational objectives for the LAMAR and their influence on the instrument design are discussed. It is concluded that the most important design parameter is the angular resolution of the LAMAR modules since it so strongly influences sensitivity, optical identifications, source confusion, spectral resolution for objective gratings and the ability to resolve small extended sources. A high resolution Wolter Type I LAMAR module is described, its hardware status discussed, and the performance of a LAMAR observatory presented. A promising technique for enhancing the reflectivity of Wolter Type I X-ray optics in a selected bandpass at high energy has been investigated and the performance of the LAMAR module, utilizing this method, has been calculated.

  5. 7 CFR 1006.51 - Class I differential, adjustments to Class I prices, and Class I price.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... MILK IN THE FLORIDA MARKETING AREA Order Regulating Handling Class Prices § 1006.51 Class I... 7 Agriculture 9 2013-01-01 2013-01-01 false Class I differential, adjustments to Class I prices, and Class I price. 1006.51 Section 1006.51 Agriculture Regulations of the Department of...

  6. 7 CFR 1006.51 - Class I differential, adjustments to Class I prices, and Class I price.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... MILK IN THE FLORIDA MARKETING AREA Order Regulating Handling Class Prices § 1006.51 Class I... 7 Agriculture 9 2012-01-01 2012-01-01 false Class I differential, adjustments to Class I prices, and Class I price. 1006.51 Section 1006.51 Agriculture Regulations of the Department of...

  7. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts a manufactured aluminum panel, that will fabricate the Ares I upper stage barrel, undergoing a confidence panel test. In this test, bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  8. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts a manufactured aluminum panel that will be used to fabricate the Ares I upper stage barrel, undergoing a confidence panel test. In this test, the bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California.

  9. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts the manufacturing of aluminum panels that will be used to form the Ares I barrel. The panels are manufacturing process demonstration articles that will undergo testing until perfected. The panels are built by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  10. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts a manufactured aluminum panel that will be used to fabricate the Ares I upper stage barrel, undergoing a confidence panel test. In this test, the bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  11. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts a manufactured aluminum panel, that will fabricate the Ares I upper stage barrel, undergoing a confidence panel test. In this test, the bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  12. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts a manufactured panel that will be used for the Ares I upper stage barrel fabrication. The aluminum panels are manufacturing process demonstration articles that will undergo testing until perfected. The panels are built by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  13. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image, depicts a manufactured aluminum panel, that will be used to fabricate the Ares I upper stage barrel, undergoing a confidence panel test. In this test, the bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  14. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts confidence testing of a manufactured aluminum panel that will fabricate the Ares I upper stage barrel. In this test, bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  15. Studies of Nonlinear Problems. I

    DOE R&D Accomplishments Database

    Fermi, E.; Pasta, J.; Ulam, S.

    1955-05-01

    A one-dimensional dynamical system of 64 particles with forces between neighbors containing nonlinear terms has been studied on the Los Alamos computer MANIAC I. The nonlinear terms considered are quadratic, cubic, and broken linear types. The results are analyzed into Fourier components and plotted as a function of time. The results show very little, if any, tendency toward equipartition of energy among the degrees of freedom.

  16. Lunar Orbiter I - Moon & Earth

    NASA Technical Reports Server (NTRS)

    1966-01-01

    First view of the earth and moon from space. Published in: Spaceflight Revolution: Langley Research Center From Sputnik to Apollo, by James R. Hansen. NASA History Series. NASA SP ; 4308. p ii. Caption: 'The picture of the century was this first view of the earth from space. Lunar Orbiter I took the photo on 23 August 1966 on its 16th orbit just before it passed behind the moon. The photo also provided a spectacular dimensional view of the lunar surface.'

  17. STS-51I Mission Insignia

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The crew emblem for STS-51I is based on a strong patriotic theme with the basic colors of red, white, and blue suggesting the American flag and a dominant American bald eagle in aggressive flight. The 19 stars signify the numerical sequence of the flight. The shock wave represents that formed by the orbited during the entry phase of the flight. Surnames of crew members surround the top part of the circular design.

  18. Ares I Integrated Test Approach

    NASA Technical Reports Server (NTRS)

    Taylor, Jim

    2008-01-01

    This slide presentation reviews the testing approach that NASA is developing for the Ares I launch vehicle. NASA is planning a complete series of development, qualification and verification tests. These include: (1) Upper stage engine sea-level and altitude testing (2) First stage development and qualification motors (3) Upper stage structural and thermal development and qualification test articles (4) Main Propulsion Test Article (MPTA) (5) Upper stage green run testing (6) Integrated Vehicle Ground Vibration Testing (IVGVT) and (7) Aerodynamic characterization testing.

  19. Ares I Upper Stage Update

    NASA Technical Reports Server (NTRS)

    Davis, Daniel J.

    2010-01-01

    These presentation slides review the progress in the development of the Ares I upper stage. The development includes development of a manufacturing and processing assembly that will reduce the time required over 100 days, development of a weld tool that is a robotic tool that is the largest welder of its kind in the United States, development of avionics and software, and development of logisitics and operations systems.

  20. Extragalatic zoo. I. [New galaxies

    SciTech Connect

    Schorn, R.A.

    1988-01-01

    The characteristics of various types of extragalactic objects are described. Consideration is given to cD galaxies, D galaxies, N galaxies, Markarian galaxies, liners, starburst galaxies, and megamasers. Emphasis is also placed on the isolated extragalatic H I region; the isolated extragalatic H II region; primeval galaxies or photogalaxies; peculiar galaxies; Arp galaxies; interacting galaxies; ring galaxies; and polar-ring galaxies. Diagrams of these objects are provided.

  1. Ares I Upper Stage Element

    NASA Technical Reports Server (NTRS)

    Chojnacki, Kent

    2009-01-01

    This slide presentation reviews the elements that make up the Ares I launch vehicle, with particular attention devoted to the upper stage of the vehicle. The upper stage elememnts, a lunar mission profile, and the upper stage objectives are reviewed. The work that Marshall Space Flight Center is doing is highlighted: work on the full scale welding process, the vertical milling machining, and the thermal protection system.

  2. Hereditary sensory neuropathy type I

    PubMed Central

    Auer-Grumbach, Michaela

    2008-01-01

    Hereditary sensory neuropathy type I (HSN I) is a slowly progressive neurological disorder characterised by prominent predominantly distal sensory loss, autonomic disturbances, autosomal dominant inheritance, and juvenile or adulthood disease onset. The exact prevalence is unknown, but is estimated as very low. Disease onset varies between the 2nd and 5th decade of life. The main clinical feature of HSN I is the reduction of sensation sense mainly distributed to the distal parts of the upper and lower limbs. Variable distal muscle weakness and wasting, and chronic skin ulcers are characteristic. Autonomic features (usually sweating disturbances) are invariably observed. Serious and common complications are spontaneous fractures, osteomyelitis and necrosis, as well as neuropathic arthropathy which may even necessitate amputations. Some patients suffer from severe pain attacks. Hypacusis or deafness, or cough and gastrooesophageal reflux have been observed in rare cases. HSN I is a genetically heterogenous condition with three loci and mutations in two genes (SPTLC1 and RAB7) identified so far. Diagnosis is based on the clinical observation and is supported by a family history. Nerve conduction studies confirm a sensory and motor neuropathy predominantly affecting the lower limbs. Radiological studies, including magnetic resonance imaging, are useful when bone infections or necrosis are suspected. Definitive diagnosis is based on the detection of mutations by direct sequencing of the SPTLC1 and RAB7 genes. Correct clinical assessment and genetic confirmation of the diagnosis are important for appropriate genetic counselling and prognosis. Differential diagnosis includes the other hereditary sensory and autonomic neuropathies (HSAN), especially HSAN II, as well as diabetic foot syndrome, alcoholic neuropathy, neuropathies caused by other neurotoxins/drugs, immune mediated neuropathy, amyloidosis, spinal cord diseases, tabes dorsalis, lepra neuropathy, or decaying skin

  3. Altus I aircraft on lakebed

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The remotely-piloted Altus I aircraft climbs away after takeoff from Rogers Dry Lake adjacent to NASA's Dryden Flight Research Center, Edwards, Calif. The short series of test flights sponsored by the Naval Postgraduate School in early August, 1997, were designed to demonstrate the ability of the experimental craft to cruise at altitudes above 40,000 feet for sustained durations. On its final flight Aug. 15, the Altus I reached an altitude of 43,500 feet. The Altus I and its sister ship, the Altus II, are variants of the Predator surveillance drone built by General Atomics/Aeronautical Systems, Inc. They are designed for high-altitude, long-duration scientific sampling missions, and are powered by turbocharged piston engines. The Altus I incorporates a single-stage turbocharger, while the Altus II, built for NASA's Environmental Research Aircraft and Sensor Technology program, sports a two-stage turbocharger to enable the craft to fly at altitudes above 55,000 feet. The Altus II, the first of the two craft to be completed, made its first flight on May 1, 1996. With its engine augmented by a single-stage turbocharger, the Altus II reached an altitude of 37,000 ft during its first series of development flights at Dryden in Aug., 1996. In Oct. of that year, the Altus II was flown in an Atmospheric Radiation Measurement study for the Department of Energy's Sandia National Laboratory in Oklahoma. During the course of those flights, the Altus II set a single-flight endurance record for remotely-operated aircraft of more than 26 hours. The Altus I, completed in 1997, flew a series of development flights at Dryden that summer. Those test flights culminated with the craft reaching an altitude of 43,500 ft while carrying a simulated 300-lb payload, a record for an unmanned aircraft powered by a piston engine augmented with a single-stage turbocharger. The Altus II sustained an altitudeof 55,000 feet for four hours in 1999. A pilot in a control station on the ground flies the

  4. The Mirrored Hand Illusion: I Control, So I Possess?

    PubMed

    Zhou, Aibao; Zhang, Yanchi; Yin, Yulong; Yang, Yang

    2015-01-01

    Certain situations may not only cause people to misjudge external information but also distort people's perception of themselves. The present study is the first to report the mirrored hand illusion which could be generated when the experimenter imitated the fist-clenching movements of the subject synchronously. The subjects formed the illusion that the experimenter's hand was "something I can control" when being imitated synchronously. In addition, a sense of ownership over the alien hand was established by integrating multisensory signals and comparing these signals with preexisting body presentations. This method might represent a new avenue for research on the formation of self-consciousness. PMID:26562891

  5. 76 FR 41279 - Agency Information Collection Activities; Form I-864, Form I-864A, Form I-864EZ, and Form I-864W...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... was previously published in the Federal Register on May 4, 2011, at 76 FR 25364, allowing for a 60-day... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities; Form I-864, Form I- 864A, Form I-864EZ, and Form I-864W; Extension of an Existing Information Collection;...

  6. 75 FR 51093 - Agency Information Collection Activities: Form I-864, Form I-864A, Form I-864EZ, and Form I-864W...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... on May 12, 2010, at 75 FR 26782, allowing for a 60-day public comment period. USCIS received 2... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-864, Form I- 864A, Form I-864EZ, and Form I-864W; Extension of a Currently Approved Information...

  7. How Can I Live with Heart Failure?

    MedlinePlus

    ... me? Should I stay in bed? ©2015, American Heart Association Multi-language Fact Sheet Topics Heart-related Conditions What is Angina? What is an ... a Coronary Angiogram? How Can I Recover From Heart Surgery? What is Carotid ... Do I Understand "Nutrition Facts" Labels? How Can I Quit Smoking? How Can ...

  8. A Manual for Enforcing Title I Comparability.

    ERIC Educational Resources Information Center

    Lawyers' Committee for Civil Rights Under Law, Washington, DC.

    This manual is a detailed guide to the "comparability requirement" and other provisions of Title I of the Elementary and Secondary Education Act of 1965 which are intended to ensure that Title I programs provide compensatory education. Section I gives an overview of Title I and its comparability provision. Section II shows how to read and analyze…

  9. 40 CFR Table I-4 to Subpart I - Table I-4 to Subpart I of Part 98-Default Emission Factors (1-Uij) for Gas Utilization Rates (Uij...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Semiconductor Manufacturing for 300 mm Wafer Size I Table I-4 to Subpart I Protection of Environment... Semiconductor Manufacturing for 300 mm Wafer Size Process type/sub-type Process gas i CF4 C2F6 CHF3 CH2F2 C3F8...

  10. <i>hhjj> production at the LHC

    SciTech Connect

    Dolan, Matthew J.; Englert, Christoph; Greiner, Nicolas; Nordstrom, Karl; Spannowsky, Michael

    2015-08-25

    The search for di-Higgs production at the LHC in order to set limits on the Higgs trilinear coupling and constraints on new physics is one of the main motivations for the LHC high-luminosity phase. Recent experimental analyses suggest that such analyses will only be successful if information from a range of channels is included. We therefore investigate di-Higgs production in association with two hadronic jets and give a detailed discussion of both the gluon- and the weak boson-fusion (WBF) contributions, with a particular emphasis on the phenomenology with modified Higgs trilinear and quartic gauge couplings. We perform a detailed investigation of the full hadronic final state and find that <i>hhjj> production should add sensitivity to a di-Higgs search combination at the HL-LHC with 3 ab-1. Since the WBF and GF contributions are sensitive to different sources of physics beyond the Standard Model, we devise search strategies to disentangle and isolate these production modes. In addition, while gluon fusion remains non-negligible in WBF-type selections, sizeable new physics contributions to the latter can still be constrained. As an example of the latter point we investigate the sensitivity that can be obtained for a measurement of the quartic Higgs–gauge boson couplings.

  11. {sup 129}I, {sup 131}I and {sup 127}I in animal thyroids after the Chernobyl nuclear accident

    SciTech Connect

    VanMiddleworth, L.; Handle, J.

    1997-10-01

    A small number of animal thyroids from Bad Hall, Austria; Ulm, Germany; and Steinkjer, Norway had {sup 131}I (half-life 8.06 d) measured between 21 and 72 d following the nuclear accident at Chernobyl on 26 April 1986. Nine years later {sup 129}I (half-life 1.57 x 10{sup 7} y) fission product and natural {sup 127}I were measured in the same thyroids. The mass ratios, {sup 129}I/{sup 131}I were calculated to the date of the Chernobyl accident and they ranged between 13 and 71. These ratios are compared to the expected ratios within an operating nuclear reactor during 2 y of operation, where the {sup 129}I/{sup 131}I{sup -1} ratio never exceeded 30. The observed ratio of {sup 129}I to natural {sup 127}I in thyroids ranged from 5 to 200 times the ratio before the accident, except that the Norwegian thyroids had {sup 129}I/{sup 127}I ratios which were less than the ratios of pre-Chernobyl thyroids from Ulm. These studies show the {sup 129}I and {sup 131}I from the Chernobyl accident were accumulated with natural {sup 127}I in animal thyroids but the isotope ratios, calculated to the release date, had wide ranges. The {sup 131}I radioactive exposure might be estimated from a fission product mixture by measuring {sup 129}I in thyroids long after the exposure to {sup 131}I, but the results would probably show a wide range of possibilities. The determining variables should be evaluated. We know of no previous data regarding both {sup 131}I and {sup 129}I in thyroid glands during the first 3 mo after the Chernobyl accident. 16 refs., 1 fig., 2 tabs.

  12. Research Summary No. 36-3, Volume I, Part I. Volume I, Part One

    NASA Technical Reports Server (NTRS)

    1960-01-01

    The Research Summary is a bimonthly report of supporting research and development conducted at the Jet Propulsion Laboratory. This periodical is issued in three volumes. Volume I contains summaries of the work accomplished by the Space Sciences, Systems, Guidance and Control, and Telecommunications Divisions of the Laboratory. Volume II contains summaries of the work accomplished by the Physical Sciences, Engineering Mechanics, Engineering Facilities, and Propulsion Divisions. All work of a classified nature is contained in Volume Ill.

  13. Structure of <i>Cryptosporidium> IMP dehydrogenase bound to an inhibitor with <i>in vivoi> antiparasitic activity

    SciTech Connect

    Kim, Youngchang; Makowska-Grzyska, Magdalena; Gorla, Suresh Kumar; Gollapalli, Deviprasad R.; Cuny, Gregory D.; Joachimiak, Andrzej; Hedstrom, Lizbeth

    2015-04-21

    Inosine 5´-monophosphate dehydrogenase (IMPDH) is a promising target for the treatment of <i>Cryptosporidium> infections. Here, the structure of <i>C. parvumi> IMPDH (<i>Cp>IMPDH) in complex with inosine 5´-monophosphate (IMP) and P131, an inhibitor with <i>in vivoi> anticryptosporidial activity, is reported. P131 contains two aromatic groups, one of which interacts with the hypoxanthine ring of IMP, while the second interacts with the aromatic ring of a tyrosine in the adjacent subunit. In addition, the amine and NO2 moieties bind in hydrated cavities, forming water-mediated hydrogen bonds to the protein. The design of compounds to replace these water molecules is a new strategy for the further optimization of <i>C. parvumi> inhibitors for both antiparasitic and antibacterial applications.

  14. <i>Decerns>: A framework for multi-criteria decision analysis

    SciTech Connect

    Yatsalo, Boris; Didenko, Vladimir; Gritsyuk, Sergey; Sullivan, Terry

    2015-02-27

    A new framework, <i>Decerns>, for multicriteria decision analysis (MCDA) of a wide range of practical problems on risk management is introduced. <i>Decerns> framework contains a library of modules that are the basis for two scalable systems: <i>DecernsMCDA> for analysis of multicriteria problems, and <i>DecernsSDSS> for multicriteria analysis of spatial options. <i>DecernsMCDA> includes well known MCDA methods and original methods for uncertainty treatment based on probabilistic approaches and fuzzy numbers. As a result, these MCDA methods are described along with a case study on analysis of multicriteria location problem.

  15. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. In this HD video image, processes for upper stage barrel fabrication are talking place. The aluminum panels are manufacturing process demonstration articles that will undergo testing until perfected. The panels are built by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  16. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. In this HD video image, processes for upper stage barrel fabrication are talking place. The aluminum panels are manufacturing process demonstration articles that will undergo testing until perfected. The panels are built by AMRO Manufacturing located in El Monte, California. (Highest resolution Available)

  17. ARES I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. In this HD video image, processes for upper stage barrel fabrication are talking place. Aluminum panels are manufacturing process demonstration articles that will undergo testing until perfected. The panels are built by AMRO Manufacturing located in El Monte, California. (Largest resolution available)

  18. PERMEABILITY OF BACTERIAL SPORES I.

    PubMed Central

    Black, S. H.; Gerhardt, Philipp

    1961-01-01

    Black, S. H. (The University of Michigan, Ann Arbor) and Philipp Gerhardt. Permeability of bacterial spores. I. Characterization of glucose uptake. J. Bacteriol. 82:743–749. 1961.—The total uptake of glucose by masses of clean, dormant spores was measured to assess their permeability. After correction for intercellular space, packed spores of Bacillus cereus strain terminalis were found in 87 determinations to be permeated by glucose to 40% of their weight. The glucose uptake was relatively independent of environmental variables, and thus was concluded to occur principally through a process of passive diffusion. PMID:13869665

  19. Mili I/O Library

    Energy Science and Technology Software Center (ESTSC)

    1996-08-23

    Mili is a high-level mesh I/O library and database developed to support computational analysis and post-processing on unstructured finite element meshes. Mili provides is self-describing database with high-level, finite element analysis-cognizant semantics, and cross-platform data portability. Mili provides analysis codes with the capability to completely describe and label the state data, which will be output do disk. Mili has both C and FORTRAN interfaces and provides for database portability by supporting both big-and little-endian binarymore » formats.« less

  20. iDriving (Intelligent Driving)

    Energy Science and Technology Software Center (ESTSC)

    2012-09-17

    iDriving identifies the driving style factors that have a major impact on fuel economy. An optimization framework is used with the aim of optimizing a driving style with respect to these driving factors. A set of polynomial metamodels is constructed to reflect the responses produced in fuel economy by changing the driving factors. The optimization framework is used to develop a real-time feedback system, including visual instructions, to enable drivers to alter their driving stylesmore » in responses to actual driving conditions to improve fuel efficiency.« less

  1. iDriving (Intelligent Driving)

    SciTech Connect

    Malikopoulos, Andreas

    2012-09-17

    iDriving identifies the driving style factors that have a major impact on fuel economy. An optimization framework is used with the aim of optimizing a driving style with respect to these driving factors. A set of polynomial metamodels is constructed to reflect the responses produced in fuel economy by changing the driving factors. The optimization framework is used to develop a real-time feedback system, including visual instructions, to enable drivers to alter their driving styles in responses to actual driving conditions to improve fuel efficiency.

  2. What I wish I had in my stockroom

    NASA Astrophysics Data System (ADS)

    Sampere, Samuel

    2015-12-01

    Most new teachers walk into their new classroom territory and find at least some equipment. Perhaps there are items there that you don't recognize. One way to get those types of questions answered is to post a question and/or picture on the TAP-L (Teaching Apparatus List) listserv (see: http://www.pira-online.org for more information). Within a few short minutes, the sender will receive at least a couple of responses. But what if a new teacher walks into a totally empty prep room? Now that teacher is tasked with purchasing useful equipment, and we know that the opportunity for a similar acquisition in the near future is slim. So you better choose wisely! Whether my new stockroom is well equipped or completely empty, I would make sure to have the following six items in my arsenal.

  3. Aquarius iPhone Application

    NASA Technical Reports Server (NTRS)

    Estes, Joseph C., Jr.; Arca. Jeremy M.; Ko, Michael A.; Oks, Boris

    2012-01-01

    The Office of the CIO at JPL has developed an iPhone application for the Aquarius/SAC-D mission. The application includes specific information about the science and purpose of the Aquarius satellite and also features daily mission news updates pulled from sources at Goddard Space Flight Center as well as Twitter. The application includes a media and data tab section. The media section displays images from the observatory, viewing construction up to the launch and also includes various videos and recorded diaries from the Aquarius Project Manager. The data tab highlights many of the factors that affect the Earth s ocean and the water cycle. The application leverages the iPhone s accelerometer to move the Aquarius Satellite over the Earth, revealing these factors. Lastly, this application features a countdown timer to the satellite s launch, which is currently counting the days since launch. This application was highly successful in promoting the Aquarius Mission and educating the public about how ocean salinity is paramount to understanding the Earth.

  4. Availability program: Phase I report

    SciTech Connect

    Thomson, S.L.; Dabiri, A.; Keeton, D.C.; Riemer, B.W.; Waganer, L.M.

    1985-05-01

    An Availability Working Group was formed within the Office of Fusion Energy in March 1984 to consider the establishment of an availability program for magnetic fusion. The scope of this program is defined to include the development of (1) a comprehensive data base, (2) empirical correlations, and (3) analytical methods for application to fusion facilities and devices. The long-term goal of the availability program is to develop a validated, integrated methodology that will provide (1) projections of plant availability and (2) input to design decisions on maintainability and system reliability requirements. The Phase I study group was commissioned to assess the status of work in progress that is relevant to the availability program. The scope of Phase I included surveys of existing data and data collection programs at operating fusion research facilities, the assessment of existing computer models to calculate system availability, and the review of methods to predict and correlate data on component failure and maintenance. The results of these investigations are reported to the Availability Working Group in this document.

  5. iEMG: Imaging electromyography.

    PubMed

    Urbanek, Holger; van der Smagt, Patrick

    2016-04-01

    Advanced data analysis and visualization methodologies have played an important role in making surface electromyography both a valuable diagnostic methodology of neuromuscular disorders and a robust brain-machine interface, usable as a simple interface for prosthesis control, arm movement analysis, stiffness control, gait analysis, etc. But for diagnostic purposes, as well as for interfaces where the activation of single muscles is of interest, surface EMG suffers from severe crosstalk between deep and superficial muscle activation, making the reliable detection of the source of the signal, as well as reliable quantification of deeper muscle activation, prohibitively difficult. To address these issues we present a novel approach for processing surface electromyographic data. Our approach enables the reconstruction of 3D muscular activity location, making the depth of muscular activity directly visible. This is even possible when deep muscles are overlaid with superficial muscles, such as seen in the human forearm. The method, which we call imaging EMG (iEMG), is based on using the crosstalk between a sufficiently large number of surface electromyographic electrodes to reconstruct the 3D generating electrical potential distribution within a given area. Our results are validated by in vivo measurements of iEMG and ultrasound on the human forearm. PMID:26852113

  6. Observation of radioactive iodine ((131)I, (129)I) in cropland soil after the Fukushima nuclear accident.

    PubMed

    Fujiwara, Hideshi

    2016-10-01

    During the early stages of the Fukushima nuclear accident, the temporal variations of (131)I deposited on the ground and of (131)I accumulated in cropland soil were monitored at a fixed location in Japan. Moreover, concentrations of long-lived radioactive iodine ((129)I) in atmospheric deposits and soil were measured to examine the feasibility of retrospectively reconstructing (131)I levels from the levels of accident-derived (129)I. The exceptionally high levels of (131)I in deposits and soil were attributed to rainfall-related deposition of radionuclides. In the crop field studied, the losses of deposited (131)I and (129)I due to volatilization were small. The atomic ratio (129)I/(131)I in the topsoil corresponded to the same ratio in deposits. The (131)I concentrations measured in the topsoil were very consistent with the (131)I concentrations reconstructed from the (129)I concentrations in the soil. PMID:27320744

  7. 78 FR 39436 - Temporary Closure of I-65 (I-70/I-65 South Split Interchange to I-70/I-65 North Split Interchange...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ... Department of Public Works and INDOT will coordinate the closure with the Indianapolis Metropolitan Police... Transportation will be informed of this proposal. Additionally, efforts have been made to work with the various... Trucking Association of this plan to temporarily close I-65, and has agreed to work with them to...

  8. Structure and proposed mechanism of α-glycerophosphate oxidase from <i>Mycoplasma pneumoniae>

    SciTech Connect

    Elkhal, Callia K.; Kean, Kelsey M.; Parsonage, Derek; Maenpuen, Somchart; Chaiyen, Pimchai; Claiborne, Al; Karplus, P. Andrew

    2015-03-14

    In this study, the formation of hydrogen peroxide (H₂O₂) by the FAD-dependent α-glycerophosphate oxidase (GlpO), is important for the pathogenesis of <i>Streptococcus pneumoniaei> and <i>Mycoplasma pneumoniaei>. The structurally known GlpO from <i>Streptococcus> sp. (<i>Ssp>GlpO) is similar to the pneumococcal protein (<i>Sp>GlpO) and provides a guide for drug design against that target. However, M. <i>pneumoniae> GlpO (<i>Mp>GlpO), having <20% sequence identity with structurally known GlpOs, appears to represent a second type of GlpO we designate as Type II GlpOs. Here, the recombinant His-tagged <i>Mp>GlpO structure is described at ~2.5 Å resolution, solved by molecular replacement using as a search model the <i>Bordetella pertussisi> protein 3253 (Bp3253) a protein of unknown function solved by structural genomics efforts. Recombinant <i>Mp>GlpO is an active oxidase with a turnover number of ~580 min⁻¹ while Bp3253 showed no GlpO activity. No substantial differences exist between the oxidized and dithionite-reduced <i>Mp>GlpO structures. Although, no liganded structures were determined, a comparison with the tartrate-bound Bp3253 structure and consideration of residue conservation patterns guided the construction of a model for α-glycerophosphate (Glp) recognition and turnover by <i>Mp>GlpO. The predicted binding mode also appears relevant for the type I GlpOs (such as <i>Ssp>GlpO) despite differences in substrate recognition residues, and it implicates a histidine conserved in type I and II Glp oxidases and dehydrogenases as the catalytic acid/base. This work provides a solid foundation for guiding further studies of the mitochondrial Glp dehydrogenases as well as for continued studies of <i>M. pneumoniaei> and <i>S. pneumoniaei> glycerol metabolism and the development of novel therapeutics targeting <i>Mp>GlpO and <i>Sp>GlpO.

  9. High-quality permanent draft genome sequence of the <i>Parapiptadenia rigidai>-nodulating <i>Cupriavidus> sp. strain UYPR2.512

    SciTech Connect

    De Meyer, Sofie E.; Fabiano, Elena; Tian, Rui; Van Berkum, Peter; Seshadri, Rekha; Reddy, T. B. K.; Markowitz, Victor; Ivanova, Natalia N.; Pati, Amrita; Woyke, Tanja; Howieson, John; Kyrpides, Nikos C.; Reeve, Wayne

    2015-04-11

    <i>Cupriavidus> sp. strain UYPR2.512 is an aerobic, motile, Gram-negative, non-spore-forming rod that was isolated from a root nodule of <i>Parapiptadenia rigidai> grown in soils from a native forest of Uruguay. Here we describe the features of <i>Cupriavidus> sp. strain UYPR2.512, together with sequence and annotation. We find the 7,858,949 bp high-quality permanent draft genome is arranged in 365 scaffolds of 369 contigs, contains 7,411 protein-coding genes and 76 RNA-only encoding genes, and is part of the GEBA-RNB project proposal.

  10. 40 CFR Appendix I to Subpart B of... - Appendix I to Subpart B of Part 205

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Appendix I to Subpart B of Part 205 I Appendix I to Subpart B of Part 205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED.... 205, Subpt. B, App. I Appendix I to Subpart B of Part 205 Table I—Sample Size Code Letters Batch...

  11. 40 CFR Appendix I to Subpart B of... - Appendix I to Subpart B of Part 205

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Appendix I to Subpart B of Part 205 I Appendix I to Subpart B of Part 205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED.... 205, Subpt. B, App. I Appendix I to Subpart B of Part 205 Table I—Sample Size Code Letters Batch...

  12. 40 CFR Appendix I to Subpart B of... - Appendix I to Subpart B of Part 205

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Appendix I to Subpart B of Part 205 I Appendix I to Subpart B of Part 205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED.... 205, Subpt. B, App. I Appendix I to Subpart B of Part 205 Table I—Sample Size Code Letters Batch...

  13. 40 CFR Appendix I to Subpart B of... - Appendix I to Subpart B of Part 205

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Appendix I to Subpart B of Part 205 I Appendix I to Subpart B of Part 205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks Pt. 205, Subpt. B, App. I Appendix I to...

  14. 40 CFR Appendix I to Subpart B of... - Appendix I to Subpart B of Part 205

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Appendix I to Subpart B of Part 205 I Appendix I to Subpart B of Part 205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED.... 205, Subpt. B, App. I Appendix I to Subpart B of Part 205 Table I—Sample Size Code Letters Batch...

  15. A Case Study of Teacher Retention in Three Title I Hawai'i Schools

    ERIC Educational Resources Information Center

    Furuta, Stephanie H.

    2015-01-01

    Teacher retention in Hawai'i is a challenge, particularly in high needs Title I schools. This qualitative case study explores the question "What factors influence teacher retention in Title I schools in Hawai'i?" The participants were 10 early career and veteran teachers from three Title I schools within one O'ahu public school complex.…

  16. Supernovae. Part I: the events

    NASA Astrophysics Data System (ADS)

    Trimble, Virginia

    1982-10-01

    Since the heroic era of Baade and Zwicky, our understanding of supernovae has advanced in hops and skips rather than steadily. The most recent jump has been into fairly general agreement that observations of Type I's can be interpreted as the manifestation of the decay of about 1Msolar of Ni56 and observations of Type II's as the manifestation of >~1051 ergs deposited at the bottom of a supergiant envelope by core bounce as a central neutron star forms. This paper explores the history of these and other ideas of what is going on in supernovae, the presupernova evolution of the parent stars and binary systems, observed properties of the events, and models for them. A later paper (Part II: the aftermath) will address the results of supernovae-their remnants, production of cosmic rays and gamma rays, nucleosynthesis, and galactic evolution-and the future of supernova research.

  17. Essential Oils, Part I: Introduction.

    PubMed

    de Groot, Anton C; Schmidt, Erich

    2016-01-01

    Essential oils are widely used in the flavor, food, fragrance, and cosmetic industries in many applications. Contact allergy to them is well known and has been described for 80 essential oils. The relevance of positive patch test reactions often remains unknown. Knowledge of the chemical composition of essential oils among dermatologists is suspected to be limited, as such data are published in journals not read by the dermatological community. Therefore, the authors have fully reviewed and published the literature on contact allergy to and chemical composition of essential oils. Selected topics from this publication will be presented in abbreviated form in Dermatitis starting with this issue, including I. Introduction; II. General aspects; III. Chemistry; IV. General aspects of contact allergy; V. Peppermint oil, lavender oil and lemongrass oil; VI: Sandalwood oil, ylang-ylang oil, and jasmine absolute. PMID:26983089

  18. Ares I Upper Stage Overview

    NASA Technical Reports Server (NTRS)

    Verhage, Marc

    2007-01-01

    The Upper Stage Element of NASA's Ares I Crew Launch Vehicle (CLV) is a "clean-sheet" approach that is being designed and developed in-house, with Element management at MSFC. The Upper Stage Element concept is a self-supporting cylindrical structure, approximately 84' long and 18' in diameter. While the First Stage Solid Rocket Booster (SRB) design has changed since the CLV inception, the Upper Stage Element design has remained essentially a clean-sheet design approach. A clean-sheet upper stage design does offer many advantages: a design for increased reliability; built-in evolvability to allow for commonality/growth without major redesign; incorporation of state-of-the-art materials and hardware; and incorporation of design, fabrication, and test techniques and processes to facilitate a more operable system.

  19. Ares I Static Tests Design

    NASA Technical Reports Server (NTRS)

    Carson, William; Lindemuth, Kathleen; Mich, John; White, K. Preston; Parker, Peter A.

    2009-01-01

    Probabilistic engineering design enhances safety and reduces costs by incorporating risk assessment directly into the design process. In this paper, we assess the format of the quantitative metrics for the vehicle which will replace the Space Shuttle, the Ares I rocket. Specifically, we address the metrics for in-flight measurement error in the vector position of the motor nozzle, dictated by limits on guidance, navigation, and control systems. Analyses include the propagation of error from measured to derived parameters, the time-series of dwell points for the duty cycle during static tests, and commanded versus achieved yaw angle during tests. Based on these analyses, we recommend a probabilistic template for specifying the maximum error in angular displacement and radial offset for the nozzle-position vector. Criteria for evaluating individual tests and risky decisions also are developed.

  20. Nanomechanics of Type I Collagen.

    PubMed

    Varma, Sameer; Orgel, Joseph P R O; Schieber, Jay D

    2016-07-12

    Type I collagen is the predominant collagen in mature tendons and ligaments, where it gives them their load-bearing mechanical properties. Fibrils of type I collagen are formed by the packing of polypeptide triple helices. Higher-order structures like fibril bundles and fibers are assembled from fibrils in the presence of other collagenous molecules and noncollagenous molecules. Curiously, however, experiments show that fibrils/fibril bundles are less resistant to axial stress compared to their constituent triple helices-the Young's moduli of fibrils/fibril bundles are an order-of-magnitude smaller than the Young's moduli of triple helices. Given the sensitivity of the Young's moduli of triple helices to solvation environment, a plausible explanation is that the packing of triple helices into fibrils perhaps reduces the Young's modulus of an individual triple helix, which results in fibrils having smaller Young's moduli. We find, however, from molecular dynamics and accelerated conformational sampling simulations that the Young's modulus of the buried core of the fibril is of the same order as that of a triple helix in aqueous phase. These simulations, therefore, suggest that the lower Young's moduli of fibrils/fibril bundles cannot be attributed to the specific packing of triple helices in the fibril core. It is not the fibril core that yields initially to axial stress. Rather, it must be the portion of the fibril exposed to the solvent and/or the fibril-fibril interface that bears the initial strain. Overall, this work provides estimates of Young's moduli and persistence lengths at two levels of collagen's structural assembly, which are necessary to quantitatively investigate the response of various biological factors on collagen mechanics, including congenital mutations, posttranslational modifications and ligand binding, and also engineer new collagen-based materials. PMID:27410733

  1. "I Hoped to Counteract the Memory Problem, but I Made No Impact Whatsoever": Discussing Methods in Computing Science Using "I"

    ERIC Educational Resources Information Center

    Harwood, Nigel

    2005-01-01

    This paper is a corpus-based study of how native speaker computing students and experts use the pronoun "I" when elaborating their methodology ("methodological I"). Using two corpora, (i) a student corpus of about 62,000 words of postgraduate computing project reports, written at the end of the MSc programme and roughly equivalent to the master's…

  2. RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation.

    PubMed

    Wang, Wendie; Jiang, Minghong; Liu, Shuo; Zhang, Shikun; Liu, Wei; Ma, Yuanwu; Zhang, Lianfeng; Zhang, Jiyan; Cao, Xuetao

    2016-08-23

    The activation of retinoic acid-inducible gene 1 (RIG-I), a cytoplasmic innate sensor for viral RNA, is tightly regulated to maintain immune homeostasis properly and prevent excessive inflammatory reactions other than initiation of antiviral innate response to eliminate RNA virus effectively. Posttranslational modifications, particularly ubiquitination, are crucial for regulation of RIG-I activity. Increasing evidence suggests that E3 ligases play important roles in various cellular processes, including cell proliferation and antiviral innate signaling. Here we identify that E3 ubiquitin ligase RING finger protein 122 (RNF122) directly interacts with mouse RIG-I through MS screening of RIG-I-interacting proteins in RNA virus-infected cells. The transmembrane domain of RNF122 associates with the caspase activation and recruitment domains (CARDs) of RIG-I; this interaction effectively triggers RING finger domain of RNF122 to deliver the Lys-48-linked ubiquitin to the Lys115 and Lys146 residues of RIG-I CARDs and promotes RIG-I degradation, resulting in a marked inhibition of RIG-I downstream signaling. RNF122 is widely expressed in various immune cells, with preferential expression in macrophages. Deficiency of RNF122 selectively increases RIG-I-triggered production of type I IFNs and proinflammatory cytokines in macrophages. RNF122-deficient mice exhibit more resistance against lethal RNA virus infection, with increased production of type I IFNs. Thus, we demonstrate that RNF122 acts as a selective negative regulator of RIG-I-triggered antiviral innate response by targeting CARDs of RIG-I and mediating proteasomal degradation of RIG-I. Our study outlines a way for E3 ligase to regulate innate sensor RIG-I for the control of antiviral innate immunity. PMID:27506794

  3. Electronic structure and optical properties of CsI, CsI(Ag), and CsI(Tl)

    NASA Astrophysics Data System (ADS)

    Zhang, Zheng; Zhao, Qiang; Li, Yang; Ouyang, Xiao-Ping

    2016-05-01

    The band structure, electronic density of states and optical properties of CsI and of CsI doped with silver or thallium are studied by using a first-principles calculation based on density functional theory (DFT). The exchange and the correlation potentials among the electrons are described by using the generalized gradient approximation (GGA). The results of our study show that the electronic structure changes somewhat when CsI is doped with silver or thallium. The band gaps of CsI(Ag) and CsI(Tl) are smaller than that of CsI, and the width of the conduction band of CsI is increased when CsI is doped with thallium or silver. Two peaks located in the conduction band of CsI(Ag) and CsI(Tl) are observed from their electronic densities of states. The absorption coefficients of CsI, CsI(Ag), and CsI(Tl) are zero when their photon energies are below 3.5 eV, 1.5 eV, and 3.1 eV, respectively. The results show that doping can improve the detection performance of CsI scintillators. Our study can explain why doping can improve the detection performance from a theoretical point of view. The results of our research provide both theoretical support for the luminescent mechanisms at play in scintillator materials when they are exposed to radiation and a reference for CsI doping from the point of view of the electronic structure.

  4. Why Do I Need X-Rays?

    MedlinePlus

    ... to your desktop! more... Why Do I Need X-Rays? Article Chapters Why Do I Need X-Rays? ... of tooth decay. Updated: January 2012 Related Articles: X-Rays The Academy of General Dentistry (AGD) Sets the ...

  5. Genetics Home Reference: complement factor I deficiency

    MedlinePlus

    ... Page Baracho GV, Nudelman V, Isaac L. Molecular characterization of homozygous hereditary factor I deficiency. Clin Exp ... G, Sánchez-Corral P, López-Trascasa M. Molecular characterization of Complement Factor I deficiency in two Spanish ...

  6. Can I prevent Pelvic Organ Prolapse

    MedlinePlus

    ... Pelvic Organ Prolapse POP Symptoms & Types Can I Prevent POP? POP Diagnosis POP Treatments 3 Resources + More Bladder Control UI Symptoms & Types Can I Prevent UI? UI Diagnosis UI Treatments 3 Resources + More ...

  7. I Think My Friend May Have an Eating Disorder. What Should I Do?

    MedlinePlus

    ... Cuts? I Think My Friend May Have an Eating Disorder. What Should I Do? KidsHealth > For Teens > I ... Signs of Eating Disorders How to Help About Eating Disorders Every year, thousands of teens (and adults, too) ...

  8. Draft genome sequence of <i>Raoultella terrigenai> R1Gly, a diazotrophic endophyte

    SciTech Connect

    Schicklberger, M.; Shapiro, N.; Loqué, D.; Woyke, T.; Chakraborty, R.

    2015-06-11

    <i>Raoultella terrigenai> R1Gly is a diazotrophic endophyte isolated from surface-sterilized roots of <i>Nicotiana tabacumi>. The whole-genome sequence was obtained to investigate the endophytic characteristics of this organism at the genetic level, as well as to compare this strain with its close relatives. To our knowledge, this is the first genome obtained from the <i>Raoultella terrigenai> species and only the third genome from the <i>Raoultella genusi>, after <i>Raoultella ornitholytici> and <i>Raoultella planticolai>. This genome will provide a foundation for further comparative genomic, metagenomic, and functional studies of this genus.

  9. Type I Interferons Direct Gammaherpesvirus Host Colonization.

    PubMed

    Tan, Cindy S E; Lawler, Clara; May, Janet S; Belz, Gabrielle T; Stevenson, Philip G

    2016-05-01

    Gamma-herpesviruses colonise lymphocytes. Murid Herpesvirus-4 (MuHV-4) infects B cells via epithelial to myeloid to lymphoid transfer. This indirect route entails exposure to host defences, and type I interferons (IFN-I) limit infection while viral evasion promotes it. To understand how IFN-I and its evasion both control infection outcomes, we used Mx1-cre mice to tag floxed viral genomes in IFN-I responding cells. Epithelial-derived MuHV-4 showed low IFN-I exposure, and neither disrupting viral evasion nor blocking IFN-I signalling markedly affected acute viral replication in the lungs. Maximising IFN-I induction with poly(I:C) increased virus tagging in lung macrophages, but the tagged virus spread poorly. Lymphoid-derived MuHV-4 showed contrastingly high IFN-I exposure. This occurred mainly in B cells. IFN-I induction increased tagging without reducing viral loads; disrupting viral evasion caused marked attenuation; and blocking IFN-I signalling opened up new lytic spread between macrophages. Thus, the impact of IFN-I on viral replication was strongly cell type-dependent: epithelial infection induced little response; IFN-I largely suppressed macrophage infection; and viral evasion allowed passage through B cells despite IFN-I responses. As a result, IFN-I and its evasion promoted a switch in infection from acutely lytic in myeloid cells to chronically latent in B cells. Murine cytomegalovirus also showed a capacity to pass through IFN-I-responding cells, arguing that this is a core feature of herpesvirus host colonization. PMID:27223694

  10. Type I Interferons Direct Gammaherpesvirus Host Colonization

    PubMed Central

    Tan, Cindy S. E.; Lawler, Clara; May, Janet S.; Belz, Gabrielle T.; Stevenson, Philip G.

    2016-01-01

    Gamma-herpesviruses colonise lymphocytes. Murid Herpesvirus-4 (MuHV-4) infects B cells via epithelial to myeloid to lymphoid transfer. This indirect route entails exposure to host defences, and type I interferons (IFN-I) limit infection while viral evasion promotes it. To understand how IFN-I and its evasion both control infection outcomes, we used Mx1-cre mice to tag floxed viral genomes in IFN-I responding cells. Epithelial-derived MuHV-4 showed low IFN-I exposure, and neither disrupting viral evasion nor blocking IFN-I signalling markedly affected acute viral replication in the lungs. Maximising IFN-I induction with poly(I:C) increased virus tagging in lung macrophages, but the tagged virus spread poorly. Lymphoid-derived MuHV-4 showed contrastingly high IFN-I exposure. This occurred mainly in B cells. IFN-I induction increased tagging without reducing viral loads; disrupting viral evasion caused marked attenuation; and blocking IFN-I signalling opened up new lytic spread between macrophages. Thus, the impact of IFN-I on viral replication was strongly cell type-dependent: epithelial infection induced little response; IFN-I largely suppressed macrophage infection; and viral evasion allowed passage through B cells despite IFN-I responses. As a result, IFN-I and its evasion promoted a switch in infection from acutely lytic in myeloid cells to chronically latent in B cells. Murine cytomegalovirus also showed a capacity to pass through IFN-I-responding cells, arguing that this is a core feature of herpesvirus host colonization. PMID:27223694

  11. How Can I Prepare for Heart Surgery?

    MedlinePlus

    ... heart Treatments + Tests How Can I Prepare for Heart Surgery? Doctors do successful heart surgery every day. But it’s normal to be concerned ... recovery to begin. How Can I Prepare for Heart Surgery? HOW CAN I LEARN MORE? Call 1-800- ...

  12. I'll Never Do It Again

    ERIC Educational Resources Information Center

    Clift, Elayne

    2009-01-01

    While online teaching may be the wave of the future, it is not for this author, who writes "I trained for it, I tried it, and I'll never do it again." An instructor with years of experience successfully teaching in collegiate classrooms, she says online teaching does not compare. So she will chalk up her first and only venture to experience and…

  13. 19 CFR 12.104i - Enforcement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Enforcement. 12.104i Section 12.104i Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY SPECIAL CLASSES OF MERCHANDISE Cultural Property § 12.104i Enforcement. In the customs territory of...

  14. Is It iTime yet?

    ERIC Educational Resources Information Center

    Blaisdell, Mikael

    2006-01-01

    Not long after its introduction into the consumer market in October of 2001, the first iPods began turning up on college campuses nationwide. Today, there are active iPod academic programs on many campuses around the country. And where there are no formal academic programs--yet--there are countless students making their own use of the iPods in…

  15. Syntheses of Arnottin I and Arnottin II

    PubMed Central

    Moschitto, Matthew J.; Anthony, David R.; Lewis, Chad A.

    2015-01-01

    Short total syntheses of arnottin I and II were accomplished in 5 and 6 steps, respectively. A sesamol-benzyne cycloaddition with a 3-furyl-benzoate followed by regiospecific lactonization provided rapid, large-scale access to the core of arnottin I. Saponification of arnottin I and hypervalent iodide mediated spirocyclization provided an efficient and direct preparation of racemic arnottin II. PMID:25748275

  16. BIOSYNTHESIS OF NITRO COMPOUNDS I.

    PubMed Central

    Shaw, Paul D.; Wang, Nancy

    1964-01-01

    Shaw, Paul D. (University of Illinois, Urbana), and Nancy Wang. Biosynthesis of nitro compounds. I. Nitrogen and carbon requirements for the biosynthesis of β-nitropropionic acid by Penicillium atrovenetum. J. Bacteriol. 88:1629–1635. 1964.—β-Nitropropionic acid was produced by Penicillium atrovenetum when this fungus was grown on a Raulin-Thom medium in shake flasks. The nitro compound was formed in the early stages of growth, and the total amount in the medium decreased when the fungus reached the end of the log phase. When increasing amounts of nitrate were substituted for the ammonia in the growth medium, production of β-nitropropionic acid decreased. Aspartic acid did not promote the synthesis of the nitro compound unless either ammonium chloride or sodium tartrate was also added to the medium. The addition of small amounts of hydroxylamine or sodium nitrite to the Raulin-Thom medium stimulated β-nitropropionic acid production to a greater degree on a molar basis than the amount of hydroxylamine or nitrite added. The nature of possible precursors to the nitro group of β-nitropropionic acid is discussed. PMID:14240949

  17. SU-E-CAMPUS-I-03: Dosimetric Comparison of the Hypoxia Agent Iodoazomycin Arabinoside (IAZA) Labeled with the Radioisotopes I-123, I-131 and I-124

    SciTech Connect

    Jans, H-S; Stypinski, D; Mcquarrie, S; Kumar, P; Mercer, J; McEwan, S; Wiebe, L

    2014-06-15

    Purpose: To compare the radiation dose to normal organs from the radio-iodinated, hypoxia-binding radiosensitizer iodoazomycin arabinoside (IAZA) for three different isotopes of iodine. Methods: Dosimety studies with normal volunteers had been carried out with [{sup 123}I]IAZA, a drug binding selectively to hypoxic sites. Two other isotopes of iodine, {sup 131}I and {sup 124}I, offer the opportunity to use IAZA as an agent for radioisotope therapy and as an imaging tracer for Positron Emission Tomography. Radioisotope dosimetry for {sup 131}I and {sup 124}I was performed by first deriving from the [{sup 123}I]IAZA studies biological uptake and excretion data. The cumulated activities for {sup 131}I or {sup 124}I where obtained by including their half-lives when integrating the biological data and then extrapolating to infinite time points considering a) physical decay only or b) physical and biological excretion. Doses were calculated using the Medical Internal Radiation Dose (MIRD) schema (OLINDA1.1 code, Vanderbilt 2007). Results: Compared to {sup 123}I, organ doses were elevated on average by a factor 6 and 9 for {sup 131}I and {sup 124}I, respectively, if both physical decay and biological excretion were modeled. If only physical decay is considered, doses increase by a factor 18 ({sup 131}I) and 19 ({sup 124}I). Highest organ doses were observed in intestinal walls, urinary bladder and thyroid. Effective doses increased by a factor 11 and 14 for {sup 131}I and {sup 124}I, respectively, if biological and physical decay are present. Purely physical decay yields a 23-fold increase over {sup 123}I for both, {sup 131}I and {sup 124}I. Conclusion: Owing to the significant dose increase, caused by their longer half life and the approximately 10 times larger electronic dose deposited in tissue per nuclear decay, normal tissue doses of IAZA labeled with {sup 131}I and {sup 124}I need to be carefully considered when designing imaging and therapy protocols for clinical

  18. Vitamin D Receptor Gene TaqI, BsmI and FokI Polymorphisms in Korean Patients with Tuberculosis

    PubMed Central

    Kang, Tae Jin; Jin, Song Hou; Yeum, Chung-Eun; Lee, Seong Beom; Kim, Chi Hong; Lee, Sang Haak; Kim, Kwan Hyoung; Shin, Eun-Soon

    2011-01-01

    Background The active metabolite (1, 25-dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to activation of macrophages and deficiency of vitamin D seems to be involved in the risk of tuberculosis. The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and may be influenced by polymorphism in the VDR gene. In this study, variation in the VDR gene was investigated in Korean population with tuberculosis. Methods We typed three VDR polymorphisms of restriction endonuclease sites for TaqI, BsmI and FokI in 155 patients with tuberculosis and 105 healthy volunteers. Results The frequencies of FokI genotypes determined from TB patients were 29.13% for FF, 56.31% for Ff, and 14.56% for ff. We observed 1.4-fold increased prevalence of the Ff genotype in TB patients compared with normal healthy groups (p=0.0857). However, there was no significant association between the genotype groups, TB patient and normal control, for FokI polymorphism. There was also no significant association between VDR gene and tuberculosis in another polymorphism (BsmI and TaqI). Conclusion Three polymorphisms (TaqI, BsmI and FokI) in the VDR gene do not appear to be responsible for host susceptibility to human tuberculosis in Korean population. PMID:22194708

  19. Improving microbial biogasoline production in <i>Escherichia colii> using tolerance engineering

    SciTech Connect

    Foo, Jee Loon; Jensen, Heather M.; Dahl, Robert H.; George, Kevin; Keasling, Jay D.; Lee, Taek Soon; Leong, Susanna; Mukhopadhyay, Aindrila

    2014-11-04

    Engineering microbial hosts for the production of fungible fuels requires mitigation of limitations posed on the production capacity. One such limitation arises from the inherent toxicity of solvent-like biofuel compounds to production strains, such as <i>Escherichia colii>. Here we show the importance of host engineering for the production of short-chain alcohols by studying the overexpression of genes upregulated in response to exogenous isopentenol. Using systems biology data, we selected 40 genes that were upregulated following isopentenol exposure and subsequently overexpressed them in <i>E. colii>. Overexpression of several of these candidates improved tolerance to exogenously added isopentenol. Genes conferring isopentenol tolerance phenotypes belonged to diverse functional groups, such as oxidative stress response (<i>soxS>, <i>fpr>, and <i>nrdH>), general stress response (<i>metR>, <i>yqhD>, and <i>gidB>), heat shock-related response (<i>ibpA>), and transport (<i>mdlB>). To determine if these genes could also improve isopentenol production, we coexpressed the tolerance-enhancing genes individually with an isopentenol production pathway. Our data show that expression of 6 of the 8 candidates improved the production of isopentenol in <i>E. colii>, with the methionine biosynthesis regulator MetR improving the titer for isopentenol production by 55%. Additionally, expression of MdlB, an ABC transporter, facilitated a 12% improvement in isopentenol production. To our knowledge, MdlB is the first example of a transporter that can be used to improve production of a short-chain alcohol and provides a valuable new avenue for host engineering in biogasoline production.

  20. IGF-I abuse in sport.

    PubMed

    Guha, Nishan; Dashwood, Alexander; Thomas, Nicholas J; Skingle, Alexander J; Sönksen, Peter H; Holt, Richard I G

    2009-09-01

    It is widely believed that growth hormone (GH) is abused by athletes for its anabolic and lipolytic effects. Many of the physiological effects of GH are mediated by the production of insulin-like growth factor-I (IGF-I). Both GH and IGF-I appear on the World Anti-Doping Agency list of prohibited substances. Little is known, however, about the prevalence of abuse with exogenous IGF-I. IGF-I has effects on carbohydrate, lipid and protein metabolism and some of these actions could prove beneficial to competitive athletes. No studies have demonstrated a positive effect of IGF-I on physical performance in healthy individuals but this has not yet been studied in appropriately designed trials. Two pharmaceutical preparations of IGF-I have recently become available for the treatment of growth disorders in children. This availability is likely to increase the prevalence of IGF-I abuse. Combining IGF-I with its binding protein IGFBP-3 in one preparation has the potential to reduce the side-effect profile but the adverse effects of long term IGF-I abuse are currently unknown. Detection of abuse with IGF-I is a major challenge for anti-doping authorities. It is extremely difficult to distinguish the exogenous recombinant form of the hormone from endogenously-produced IGF-I. One approach currently being investigated is based on measuring markers of GH and IGF-I action. This has already proved successful in the fight against GH abuse and, it is hoped, will subsequently lead to a similar test for detection of IGF-I abuse. PMID:20443773

  1. Scalable I/O Tracing and Analysis

    SciTech Connect

    Vijayakumar, Karthik; Mueller, Frank; Ma, Xiaosong; Roth, Philip C

    2009-01-01

    As supercomputer performance approached and then surpassed the petaflop level, I/O performance has become a major performance bottleneck for many scientific applications. Several tools exist to collect I/O traces to assist in the analysis of I/O performance problems. However, these tools either produce extremely large trace files that complicate performance analysis, or sacrifice accuracy to collect high-level statistical information. We propose a multi-level trace generator tool, ScalaIOTrace, that collects traces at several levels in the HPC I/O stack. ScalaIOTrace features aggressive trace compression that generates trace files of near constant size for regular I/O patterns and orders of magnitudes smaller for less regular ones. This enables the collection of I/O and communication traces of applications running on thousands of processors. Our contributions also include automated trace analysis to collect selected statistical information of I/O calls by parsing the compressed trace on-the-fly and time-accurate replay of communication events with MPI-IO calls. We evaluated our approach with the Parallel Ocean Program (POP) climate simulation and the FLASH parallel I/O benchmark. POP uses NetCDF as an I/O library while FLASH I/O uses the parallel HDF5 I/O library, which internally maps onto MPI-IO. We collected MPI-IO and low-level POSIX I/O traces to study application I/O behavior. Our results show constant size trace files of only 145KB irrespective of the number of nodes for FLASH I/O benchmark, which exhibits regular I/O and communication pattern. For POP, we observe up to two orders of magnitude reduction in trace file sizes compared to flat traces. Statistical information gathered reveals insight on the number of I/O and communication calls issued in the POP and FLASH I/O. Such concise traces are unprecedented for isolated I/O and combined I/O plus communication tracing.

  2. Performance and breakdown characteristics of irradiated vertical power GaN <i>P-i-N> diodes

    SciTech Connect

    King, M. P.; Armstrong, A. M.; Dickerson, J. R.; Vizkelethy, G.; Fleming, R. M.; Campbell, J.; Wampler, W. R.; Kizilyalli, I. C.; Bour, D. P.; Aktas, O.; Nie, H.; Disney, D.; Wierer, Jr., J.; Allerman, A. A.; Moseley, M. W.; Kaplar, R. J.

    2015-10-29

    Electrical performance and defect characterization of vertical GaN <i>P-i-N> diodes before and after irradiation with 2.5 MeV protons and neutrons is investigated. Devices exhibit increase in specific on-resistance following irradiation with protons and neutrons, indicating displacement damage introduces defects into the p-GaN and n- drift regions of the device that impact on-state device performance. The breakdown voltage of these devices, initially above 1700 V, is observed to decrease only slightly for particle fluence <; 1013 cm-2. Furthermore, the unipolar figure of merit for power devices indicates that while the on-resistance and breakdown voltage degrade with irradiation, vertical GaN <i>P-i-Ns> remain superior to the performance of the best available, unirradiated silicon devices and on-par with unirradiated modern SiC-based power devices.

  3. 25 CFR 26.33 - How do I show I need job training?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How do I show I need job training? 26.33 Section 26.33 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM Training Services § 26.33 How do I show I need job training? The need for Job Placement...

  4. 25 CFR 26.33 - How do I show I need job training?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How do I show I need job training? 26.33 Section 26.33 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM Training Services § 26.33 How do I show I need job training? The need for Job Placement...

  5. 40 CFR 63.5714 - How do I demonstrate compliance if I use filled resins?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I demonstrate compliance if I... Molding Resin and Gel Coat Operations § 63.5714 How do I demonstrate compliance if I use filled resins? (a) If you are using a filled production resin or filled tooling resin, you must demonstrate...

  6. 30 CFR 203.75 - What risk do I run if I request a redetermination?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What risk do I run if I request a redetermination? 203.75 Section 203.75 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND... Expansion Projects § 203.75 What risk do I run if I request a redetermination? If you request...

  7. 30 CFR 203.75 - What risk do I run if I request a redetermination?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What risk do I run if I request a redetermination? 203.75 Section 203.75 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT... Sulfur General § 203.75 What risk do I run if I request a redetermination? If you request...

  8. 30 CFR 203.75 - What risk do I run if I request a redetermination?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What risk do I run if I request a redetermination? 203.75 Section 203.75 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT... Sulfur General § 203.75 What risk do I run if I request a redetermination? If you request...

  9. 30 CFR 203.75 - What risk do I run if I request a redetermination?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What risk do I run if I request a redetermination? 203.75 Section 203.75 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT... Sulfur General § 203.75 What risk do I run if I request a redetermination? If you request...

  10. 20 CFR 411.135 - What do I do when I receive a ticket?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What do I do when I receive a ticket? 411.135 Section 411.135 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Tickets Under the Ticket to Work Program § 411.135 What do I do when I receive a ticket?...

  11. 47 CFR 1.10004 - What am I allowed to do if I am approved?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false What am I allowed to do if I am approved? 1.10004 Section 1.10004 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Grants by Random Selection International Bureau Filing System § 1.10004 What am I allowed to do if I...

  12. 47 CFR 1.10004 - What am I allowed to do if I am approved?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false What am I allowed to do if I am approved? 1.10004 Section 1.10004 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Grants by Random Selection International Bureau Filing System § 1.10004 What am I allowed to do if I...

  13. 47 CFR 1.10004 - What am I allowed to do if I am approved?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false What am I allowed to do if I am approved? 1.10004 Section 1.10004 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE International Bureau Filing System § 1.10004 What am I allowed to do if I am approved? If you are approved...

  14. 47 CFR 1.10004 - What am I allowed to do if I am approved?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false What am I allowed to do if I am approved? 1.10004 Section 1.10004 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Grants by Random Selection International Bureau Filing System § 1.10004 What am I allowed to do if I...

  15. 47 CFR 1.10004 - What am I allowed to do if I am approved?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false What am I allowed to do if I am approved? 1.10004 Section 1.10004 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE International Bureau Filing System § 1.10004 What am I allowed to do if I am approved? If you are approved...

  16. 21 CFR 822.5 - How will I know if I must conduct postmarket surveillance?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false How will I know if I must conduct postmarket surveillance? 822.5 Section 822.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Notification § 822.5 How will I know if I...

  17. 13 CFR 134.616 - How will I know if I receive an award?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false How will I know if I receive an award? 134.616 Section 134.616 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF... Justice Act § 134.616 How will I know if I receive an award? The ALJ will issue an initial decision on...

  18. 13 CFR 134.616 - How will I know if I receive an award?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false How will I know if I receive an award? 134.616 Section 134.616 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF... Justice Act § 134.616 How will I know if I receive an award? The ALJ will issue an initial decision on...

  19. 21 CFR 822.5 - How will I know if I must conduct postmarket surveillance?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false How will I know if I must conduct postmarket surveillance? 822.5 Section 822.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Notification § 822.5 How will I know if I...

  20. 25 CFR 247.8 - What am I responsible for if I use the facilities?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What am I responsible for if I use the facilities? 247.8 Section 247.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.8 What am I responsible for if I use the facilities?...

  1. 25 CFR 247.8 - What am I responsible for if I use the facilities?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What am I responsible for if I use the facilities? 247.8 Section 247.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.8 What am I responsible for if I use the facilities?...

  2. 25 CFR 247.8 - What am I responsible for if I use the facilities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What am I responsible for if I use the facilities? 247.8 Section 247.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.8 What am I responsible for if I use the facilities?...

  3. 25 CFR 247.8 - What am I responsible for if I use the facilities?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What am I responsible for if I use the facilities? 247.8 Section 247.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.8 What am I responsible for if I use the facilities?...

  4. 12 CFR 555.300 - Must I inform OTS before I use electronic means or facilities?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Must I inform OTS before I use electronic means... THE TREASURY ELECTRONIC OPERATIONS Requirements Applicable to All Savings Associations § 555.300 Must I inform OTS before I use electronic means or facilities? (a) General. A savings association...

  5. 30 CFR 280.11 - What must I do before I may conduct scientific research?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Apply for a Permit or File a Notice § 280.11 What must I do before I may conduct scientific research? You may conduct G&G scientific research activities related to hard minerals on the OCS only after you... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I do before I may conduct...

  6. 40 CFR 1051.210 - May I get preliminary approval before I complete my application?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false May I get preliminary approval before I complete my application? 1051.210 Section 1051.210 Protection of Environment ENVIRONMENTAL... VEHICLES Certifying Engine Families § 1051.210 May I get preliminary approval before I complete...

  7. 40 CFR 1048.210 - May I get preliminary approval before I complete my application?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false May I get preliminary approval before I complete my application? 1048.210 Section 1048.210 Protection of Environment ENVIRONMENTAL...-IGNITION ENGINES Certifying Engine Families § 1048.210 May I get preliminary approval before I complete...

  8. Protein geranylgeranyltransferase-I of Trypanosoma cruzi

    PubMed Central

    Yokoyama, Kohei; Gillespie, John R.; Van Voorhis, Wesley C.; Buckner, Frederick S.; Gelb, Michael H.

    2008-01-01

    Protein geranylgeranyltransferase type I (PGGT-I) and protein farnesyltransferase (PFT) occur in many eukaryotic cells. Both consist of two subunits, the common αsubunit and a distinct β subunit. In the gene database of protozoa Trypanosoma cruzi, the causative agent of Chagas' disease, a putative protein that consists of 401 amino acids with ∼20% amino acid sequence identity to the PGGT-I β of other species was identified, cloned, and characterized. Multiple sequence alignments show that the T. cruzi ortholog contains all three of the zinc-binding residues and several residues uniquely conserved in the β subunit of PGGT-I. Co-expression of this protein and the α subunit of T. cruzi PFT in Sf9 insect cells yielded a dimeric protein that forms a tight complex selectively with [3H]geranylgeranyl pyrophosphate, indicating a key characteristic of a functional PGGT-I. Recombinant T. cruzi PGGT-I ortholog showed geranylgeranyltransferase activity with distinct specificity toward the C-terminal CaaX motif of protein substrates compared to that of the mammalian PGGT-I and T. cruzi PFT. Most of the CaaX-containing proteins with X=Leu are good substrates of T. cruzi PGGT-I, and those with X=Met are substrates for both T. cruzi PFT and PGGT-I, whereas unlike mammalian PGGT-I, those with X=Phe are poor substrates for T. cruzi PGGT-I. Several candidates for T. cruzi PGGT-I or PFT substrates containing the C-terminal CaaX motif are found in the T. cruzi gene database. Among five C-terminal peptides of those tested, a peptide of a Ras-like protein ending with CVLL was selectively geranylgeranylated by T. cruzi PGGT-I. Other peptides with CTQQ (Tcj2 DNAJ protein), CAVM (TcPRL-1 protein tyrosine phosphatase), CHFM (a small GTPase like protein), and CQLF (TcRho1 GTPase) were specific substrates for T. cruzi PFT but not for PGGT-I. The mRNA and protein of the T. cruzi PGGT-I β ortholog were detected in three life-cycle stages of T. cruzi. Cytosol fractions from

  9. Characterization of novel sorghum <i>brown midribi> mutants from an EMS-mutagenized population

    SciTech Connect

    Sattler, Scott E.; Saballos, Ana; Xin, Zhanguo; Funnell-Harris, Deanna L.; Vermerris, Wilfred; Pedersen, Jeffrey F.

    2014-09-02

    Reducing lignin concentration in lignocellulosic biomass can increase forage digestibility for ruminant livestock and saccharification yields of biomass for bioenergy. In sorghum (<i>Sorghum bicolori> (L.) Moench) and several other C4 grasses, <i>brown midribi> (<i>bmr>) mutants have been shown to reduce lignin concentration. Putative <i>bmr> mutants isolated from an EMS-mutagenized population were characterized and classified based on their leaf midrib phenotype and allelism tests with the previously described sorghum <i>bmr> mutants <i>bmr2i>, <i>bmr6i>, and <i>bmr12i>. These tests resulted in the identification of additional alleles of <i>bmr2i>, <i>bmr6i>,and <i>bmr12i>, and, in addition, six <i>bmr> mutants were identified that were not allelic to these previously described loci. Further allelism testing among these six <i>bmr> mutants showed that they represented four novel <i>bmr> loci. Based on this study, the number of <i>bmr> loci uncovered in sorghum has doubled. The impact of these lines on agronomic traits and lignocellulosic composition was assessed in a 2-yr field study. Most of the identified <i>bmr> lines showed reduced lignin concentration of their biomass relative to wild-type (WT). Effects of the six new <i>bmr> mutants on enzymatic saccharification of lignocellulosic materials were determined, but the amount of glucose released from the stover was similar to WT in all cases. Like <i>bmr2i>, <i>bmr6i>, and <i>bmr12i>, these mutants may affect monolignol biosynthesis and may be useful for bioenergy and forage improvement when stacked together or in combination with the three previously described <i>bmr> alleles.

  10. Expression of the <i>Acidothermus cellulolyticusi> E1 endoglucanase in <i>Caldicellulosiruptor besciii> enhances its ability to deconstruct crystalline cellulose

    SciTech Connect

    Chung, Daehwan; Young, Jenna; Cha, Minseok; Brunecky, Roman; Bomble, Yannick J.; Himmel, Michael E.; Westpheling, Janet

    2015-08-13

    The <i>Caldicellulosiruptor besciii> genome encodes a potent set of carbohydrate-active enzymes (CAZymes), found primarily as multi-domain enzymes that exhibit high cellulolytic and hemicellulolytic activity on and allow utilization of a broad range of substrates, including plant biomass without conventional pretreatment. CelA, the most abundant cellulase in the <i>C. besciii> secretome, uniquely combines a GH9 endoglucanase and a GH48 exoglucanase in one protein. The most effective commercial enzyme cocktails used in vitro to pretreat biomass are derived from fungal cellulases (cellobiohydrolases, endoglucanases and a β-d-glucosidases) that act synergistically to release sugars for microbial conversion. The <i>C. besciii> genome contains six GH5 domains in five different open reading frames. Four exist in multi-domain proteins and two as single catalytic domains. E1 is a GH5 endoglucanase reported to have high specific activity and simple architecture and is active at the growth temperature of <i>C. besciii>. E1 is an endo-1,4-β-glucanase linked to a family 2 carbohydrate-binding module shown to bind primarily to cellulosic substrates. As a result, we tested if the addition of this protein to the <i>C. besciii> secretome would improve its cellulolytic activity.

  11. Atmospheric chemistry of i-butanol.

    PubMed

    Andersen, V F; Wallington, T J; Nielsen, O J

    2010-12-01

    Smog chamber/FTIR techniques were used to determine rate constants of k(Cl + i-butanol) = (2.06 ± 0.40) × 10(-10), k(Cl + i-butyraldehyde) = (1.37 ± 0.08) × 10(-10), and k(OH + i-butanol) = (1.14 ± 0.17) × 10(-11) cm(3) molecule(-1) s(-1) in 700 Torr of N(2)/O(2) diluent at 296 ± 2K. The UV irradiation of i-butanol/Cl(2)/N(2) mixtures gave i-butyraldehyde in a molar yield of 53 ± 3%. The chlorine atom initiated oxidation of i-butanol in the absence of NO gave i-butyraldehyde in a molar yield of 48 ± 3%. The chlorine atom initiated oxidation of i-butanol in the presence of NO gave (molar yields): i-butyraldehyde (46 ± 3%), acetone (35 ± 3%), and formaldehyde (49 ± 3%). The OH radical initiated oxidation of i-butanol in the presence of NO gave acetone in a yield of 61 ± 4%. The reaction of chlorine atoms with i-butanol proceeds 51 ± 5% via attack on the α-position to give an α-hydroxy alkyl radical that reacts with O(2) to give i-butyraldehyde. The atmospheric fate of (CH(3))(2)C(O)CH(2)OH alkoxy radicals is decomposition to acetone and CH(2)OH radicals. The atmospheric fate of OCH(2)(CH(3))CHCH(2)OH alkoxy radicals is decomposition to formaldehyde and CH(3)CHCH(2)OH radicals. The results are consistent with, and serve to validate, the mechanism that has been assumed in the estimation of the photochemical ozone creation potential of i-butanol. PMID:21049965

  12. Relationship between 129I and 127I contents in bovine thyroid glands from Argentina

    NASA Astrophysics Data System (ADS)

    Negri, A. E.; Fernández Niello, J. O.; Wallner, A.; Arazi, A.; Steier, P.

    2013-01-01

    129I/127I ratios and iodine concentrations in bovine thyroids stemming from Argentina were determined by accelerator mass spectrometry (AMS) and gas chromatography (GC), respectively. From these measurements, a relationship of the 129I/127I ratio with iodine content in the gland was obtained. A weak correlation between the two isotopes was found, suggesting that 129I re-emission from the ocean is not the only process for the 129I deposition in Argentina. Moreover, contributions to the total 129I inventory in the Southern hemisphere from both natural and anthropogenic sources were theoretically studied. Surface compartments present similar contribution from natural sources and nuclear explosions fallout.

  13. Structural basis for suppression of hypernegative DNA supercoiling by <i>E. colii> topoisomerase I

    SciTech Connect

    Tan, Kemin; Zhou, Qingxuan; Cheng, Bokun; Zhang, Zhongtao; Joachimiak, Andrzej; Tse-Dinh, Yuk -Ching

    2015-10-20

    <i>Escherichia colii> topoisomerase I has an essential function in preventing hypernegative supercoiling of DNA. A full length structure of <i>E. colii> topoisomerase I reported here shows how the C-terminal domains bind single-stranded DNA (ssDNA) to recognize the accumulation of negative supercoils in duplex DNA. These C-terminal domains of <i>E. colii> topoisomerase I are known to interact with RNA polymerase, and two flexible linkers within the C-terminal domains may assist in the movement of the ssDNA for the rapid removal of transcription driven negative supercoils. The structure has also unveiled for the first time how the 4-Cys zinc ribbon domain and zinc ribbon-like domain bind ssDNA with primarily π -stacking interactions. Finally, this novel structure, in combination with new biochemical data, provides important insights into the mechanism of genome regulation by type IA topoisomerases that is essential for life, as well as the structures of homologous type IA TOP3α and TOP3β from higher eukaryotes that also have multiple 4-Cys zinc ribbon domains required for their physiological functions.

  14. Termination I in Brazilian speleothems

    NASA Astrophysics Data System (ADS)

    Wang, X.; Edwards, R.; Auler, A.; Kong, X.; da Cruz, F.; Cheng, H.; Wang, Y.; Broecker, W. S.

    2009-12-01

    We have extended the high-resolution oxygen isotopic record of cave calcite from Gruta do Padre (PAD), central Brazil, now from 20 through 10 thousand years (ky) ago to characterize the abrupt climate events during Termination I. The chronology was determined by U-Th ages from 2 stalagmites. Tests for equilibrium conditions show that oxygen isotopic variations are primarily caused by climate change. We therefore interpreted the PAD record in terms of meteoric precipitation changes at this low-latitude location. The oxygen isotopic profile shows clear abrupt millennial-scale variations with amplitudes as large as 5 per mil during the last deglacial period. Using independent age scales, we compare the record to contemporaneous records from caves in northeastern and southern Brazil (Botuvera), eastern China (Hulu/Dongge) and high latitude ice cores. During the last deglaciation, PAD d18O positively correlates with the speleothem record from Botuvera, however anti-correlates remarkably with the Hulu/Dongge monsoon records and northern high-latitude ice core records. This is likely related to the displacement of the mean position of the intertropical convergence zone and associated asymmetry of Hadley cells, consistent with an oceanic meridional overturning circulation mechanism for driving the abrupt climate events. With improvement on both the chronology and d18O resolution, we identified finer structures in the PAD abrupt climatic transitions. For instance, the “Heinrich Stadial 1” (HS1) equivalent event in the record is characterized with relatively high d18O in the early interval, but low value after ~16 ky until an abrupt increase of 2 per mill at ~14.6 ky, the interval that coincides with the resumption of stalagmite growth in northeastern Brazil. The “Younger Dryas” equivalent event in PAD has amplitude half of that in HS1. This pattern is consistent with the observations in Chinese and other Brazilian speleothem records, but different from those in the

  15. Ares I-X Flight Test Vehicle Similitude to the Ares I Crew Launch Vehicle

    NASA Technical Reports Server (NTRS)

    Huebner, Lawrence D.; Smith, R. Marshall; Campbell, John R.; Taylor, Terry L.

    2009-01-01

    The Ares I-X Flight Test Vehicle is the first in a series of flight test vehicles that will take the Ares I Crew Launch Vehicle design from development to operational capability. Ares I-X is scheduled for a 2009 flight date, early enough in the Ares I design and development process so that data obtained from the flight can impact the design of Ares I before its Critical Design Review. Decisions on Ares I-X scope, flight test objectives, and FTV fidelity were made prior to the Ares I systems requirements being baselined. This was necessary in order to achieve a development flight test to impact the Ares I design. Differences between the Ares I-X and the Ares I configurations are artifacts of formulating this experimental project at an early stage and the natural maturation of the Ares I design process. This paper describes the similarities and differences between the Ares I-X Flight Test Vehicle and the Ares I Crew Launch Vehicle. Areas of comparison include the outer mold line geometry, aerosciences, trajectory, structural modes, flight control architecture, separation sequence, and relevant element differences. Most of the outer mold line differences present between Ares I and Ares I-X are minor and will not have a significant effect on overall vehicle performance. The most significant impacts are related to the geometric differences in Orion Crew Exploration Vehicle at the forward end of the stack. These physical differences will cause differences in the flow physics in these areas. Even with these differences, the Ares I-X flight test is poised to meet all five primary objectives and six secondary objectives. Knowledge of what the Ares I-X flight test will provide in similitude to Ares I - as well as what the test will not provide - is important in the continued execution of the Ares I-X mission leading to its flight and the continued design and development of Ares I.

  16. Under-detection of endospore-forming <i>Firmicutes> in metagenomic data

    SciTech Connect

    Filippidou, Sevasti; Junier, Thomas; Wunderlin, Tina; Lo, Chien -Chi; Li, Po -E; Chain, Patrick S.; Junier, Pilar

    2015-04-25

    Microbial diversity studies based on metagenomic sequencing have greatly enhanced our knowledge of the microbial world. However, one caveat is the fact that not all microorganisms are equally well detected, questioning the universality of this approach. <i>Firmicutes> are known to be a dominant bacterial group. Several <i>Firmicutes> species are endospore formers and this property makes them hardy in potentially harsh conditions, and thus likely to be present in a wide variety of environments, even as residents and not functional players. While metagenomic libraries can be expected to contain endospore formers, endospores are known to be resilient to many traditional methods of DNA isolation and thus potentially undetectable. In this study we evaluated the representation of endospore-forming <i>Firmicutes> in 73 published metagenomic datasets using two molecular markers unique to this bacterial group (<i>spo0Ai> and <i>gpr>). Both markers were notably absent in well-known habitats of <i>Firmicutes> such as soil, with <i>spo0Ai> found only in three mammalian gut microbiomes. A tailored DNA extraction method resulted in the detection of a large diversity of endospore-formers in amplicon sequencing of the 16S rRNA and <i>spo0Ai> genes. However, shotgun classification was still poor with only a minor fraction of the community assigned to <i>Firmicutes>. Thus, removing a specific bias in a molecular workflow improves detection in amplicon sequencing, but it was insufficient to overcome the limitations for detecting endospore-forming <i>Firmicutes> in whole-genome metagenomics. In conclusion, this study highlights the importance of understanding the specific methodological biases that can contribute to improve the universality of metagenomic approaches.

  17. 30 CFR Appendix I to Subpart J of... - Appendix I to Subpart J of Part 7

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Appendix I to Subpart J of Part 7 I Appendix I to Subpart J of Part 7 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Assemblies Pt. 7, Subpt. J, App. I Appendix I to Subpart J of Part 7 EC22OC91.004 EC22OC91.005...

  18. Adiabatic invariance of oscillons/I -balls

    NASA Astrophysics Data System (ADS)

    Kawasaki, Masahiro; Takahashi, Fuminobu; Takeda, Naoyuki

    2015-11-01

    Real scalar fields are known to fragment into spatially localized and long-lived solitons called oscillons or I -balls. We prove the adiabatic invariance of the oscillons/I -balls for a potential that allows periodic motion even in the presence of non-negligible spatial gradient energy. We show that such a potential is uniquely determined to be the quadratic one with a logarithmic correction, for which the oscillons/I -balls are absolutely stable. For slightly different forms of the scalar potential dominated by the quadratic one, the oscillons/I -balls are only quasistable, because the adiabatic charge is only approximately conserved. We check the conservation of the adiabatic charge of the I -balls in numerical simulation by slowly varying the coefficient of logarithmic corrections. This unambiguously shows that the longevity of oscillons/I -balls is due to the adiabatic invariance.

  19. Investigations of the F conjugation gene traI:traI mutants and lambdatraI transducing phages.

    PubMed

    Willetts, N; Maule, J

    1979-02-01

    A series of traI point and deletion mutants of Flac, and a traM mutant, were characterised. Complementation tests with an amber Flac traI mutant confirmed their genotypes, and in addition all the traI mutants, but not the traM mutant, were complemented by pRS31 (PSC101 traDI) and EDlambda109 (lambdatraI). Judging from the efficiencies of plating of F-specific phages, none of the mutations affected pilus formation. The traI products of F and of the F-like plasmid R1 were interchangeable with each other but not with that of R100, while the traM product of F could not be replaced by those of R1 or of R100. Neither traI nor traM were needed for conjugal transfer of ColE1. Three lambda transducing phages carrying traI were isolated by in vivo or in vitro techniques, and characterised by genetic complementation tests, by analysis of the fragments produced by restriction endonucleases, and by measurement of heteroduplex molecules. The genetic structures together with the sizes and F coordinates, of the transfer regions carried by the phages were thereby determined. Comparison of the proteins synthesised in UV-irradiated cells by one of the lambdatraI phages with those made by a derivative carrying an amber traI mutation, allowed the traI product to be identified as a protein of molecular weight 174,000. In addition, the molecular weights of the traD (84,000), traS (18,000), and traT (25,000) products made by the lambdatraSTD1 phage EDlambda107 were measured. The possible roles of the traI and traM products in conjugation are discussed. PMID:372754

  20. Rare case of orofaciodigital syndrome type I

    PubMed Central

    Singh, Abhishek Bahadur; Girhotra, Manish; Goel, Medha; Bhatia, Shilpee

    2013-01-01

    Orofaciodigital syndrome (OFDS) is a group of congenital anomalies which affects the face, oral structures and digits. There are nine subtypes with different modes of inheritance. OFDS type I is an X-linked dominant trait with lethality in the vast majority of affected males. We report a case of OFDS type I in an Indian girl at the age of seven who had most of the typical features of OFDS type I and nephrocalcinosis. PMID:23417374

  1. Leading a successful iGEM team.

    PubMed

    Materi, Wayne

    2012-01-01

    The International Genetically Engineered Machines (iGEM) competition allows undergraduate teams to develop projects in synthetic biology within the context of a large, international Jamboree. Organizing and managing a successful iGEM team is an exercise in advanced agile project development. While many of the principles applicable to such teams are derived from management of agile software teams, iGEM presents several unique challenges. PMID:22328439

  2. New organically templated photoluminescence iodocuprates(I)

    SciTech Connect

    Hou Qin; Zhao Jinjing; Zhao Tianqi; Jin Juan; Yu Jiehui; Xu Jiqing

    2011-07-15

    Two types of organic cyclic aliphatic diamine molecules piperazine (pip) and 1,3-bis(4-piperidyl)propane (bpp) were used, respectively, to react with an inorganic mixture of CuI and KI in the acidic CH{sub 3}OH solutions under the solvothermal conditions, generating finally three new organically templated iodocuprates as 2-D layered [(Hpip)Cu{sub 3}I{sub 4}] 1, 1-D chained [tmpip][Cu{sub 2}I{sub 4}] 2 (tmpip=N,N,N',N'-tetramethylpiperazinium) and dinuclear [H{sub 2}bpp]{sub 2}[Cu{sub 2}I{sub 5}] I.2H{sub 2}O 3. Note that the templating agent tmpip{sup 2+} in compound 2 originated from the in situ N-alkylation reaction between the pip molecule and the methanol solvent. The photoluminescence analysis indicates that the title compounds emit the different lights: yellow for 1, blue for 2 and yellow-green for 3, respectively. - Graphical abstract: The solvothermal self-assemblies of CuI, KI and pip/bpp in acidic CH{sub 3}OH solutions created three iodocuprates 2-D layered [(Hpip)Cu{sub 3}I{sub 4}] 1, 1-D chained [tmpip][Cu{sub 2}I{sub 4}] 2 and dinuclear [H{sub 2}bpp]{sub 2}[Cu{sub 2}I{sub 5}] I.2H{sub 2}O 3. Highlights: > A new layered iodocuprate(I) with 20-membered rings was hydrothermally prepared. > A simple approach to prepare the new organic templating agent was reported. > Photoluminescence analysis indicates the emission for iodocuprate(I) is associated with the Cu...Cu interactions.

  3. Experimental Breeder Reactor I Preservation Plan

    SciTech Connect

    Julie Braun

    2006-10-01

    Experimental Breeder Reactor I (EBR I) is a National Historic Landmark located at the Idaho National Laboratory, a Department of Energy laboratory in southeastern Idaho. The facility is significant for its association and contributions to the development of nuclear reactor testing and development. This Plan includes a structural assessment of the interior and exterior of the EBR I Reactor Building from a preservation, rather than an engineering stand point and recommendations for maintenance to ensure its continued protection.

  4. CBP PHASE I CODE INTEGRATION

    SciTech Connect

    Smith, F.; Brown, K.; Flach, G.; Sarkar, S.

    2011-09-30

    The goal of the Cementitious Barriers Partnership (CBP) is to develop a reasonable and credible set of software tools to predict the structural, hydraulic, and chemical performance of cement barriers used in nuclear applications over extended time frames (greater than 100 years for operating facilities and greater than 1000 years for waste management). The simulation tools will be used to evaluate and predict the behavior of cementitious barriers used in near surface engineered waste disposal systems including waste forms, containment structures, entombments, and environmental remediation. These cementitious materials are exposed to dynamic environmental conditions that cause changes in material properties via (i) aging, (ii) chloride attack, (iii) sulfate attack, (iv) carbonation, (v) oxidation, and (vi) primary constituent leaching. A set of state-of-the-art software tools has been selected as a starting point to capture these important aging and degradation phenomena. Integration of existing software developed by the CBP partner organizations was determined to be the quickest method of meeting the CBP goal of providing a computational tool that improves the prediction of the long-term behavior of cementitious materials. These partner codes were selected based on their maturity and ability to address the problems outlined above. The GoldSim Monte Carlo simulation program (GTG 2010a, GTG 2010b) was chosen as the code integration platform (Brown & Flach 2009b). GoldSim (current Version 10.5) is a Windows based graphical object-oriented computer program that provides a flexible environment for model development (Brown & Flach 2009b). The linking of GoldSim to external codes has previously been successfully demonstrated (Eary 2007, Mattie et al. 2007). GoldSim is capable of performing deterministic and probabilistic simulations and of modeling radioactive decay and constituent transport. As part of the CBP project, a general Dynamic Link Library (DLL) interface was

  5. Deoxyribonuclease I in mammalian tissues. [Rats

    SciTech Connect

    Lacks, S.A.

    1981-03-25

    Enzymes of the DNase I class, similar to bovine pancreatic DNase I with respect to molecular weight and ionic and pH requirements, were found in various tissues of the rat. Their analysis was facilitated by a method for detection of nucleases in crude extracts after polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and subsequent renaturation of the enzymes. High levels of DNase I were found in digestive tissues, such as the parotid and submaxillary salivary glands and the lining of the small intestine. Appreciable levels were present in the lymph node, kidney, heart, prostate gland, and seminal vesicle. No activity was found in pancreatic extracts. However, under some conditions, tissues rich in proteases gave poor recovery of DNase I. Fourteen other tissues showed little or no DNase I. Inhibition of various DNase I enzymes by rabbit muscle actin was examined both in gels and in solution. Actin inhibited the bovine parotid DNase I as well as the bovine pancreatic enzyme, but actin did not inhibit any of the DNase I enzymes of the rat. This species specificity of actin inhibition makes it unlikely that the very strong association between monomeric actin and bovine DNase I is of general significance for cellular function.

  6. File concepts for parallel I/O

    NASA Technical Reports Server (NTRS)

    Crockett, Thomas W.

    1989-01-01

    The subject of input/output (I/O) was often neglected in the design of parallel computer systems, although for many problems I/O rates will limit the speedup attainable. The I/O problem is addressed by considering the role of files in parallel systems. The notion of parallel files is introduced. Parallel files provide for concurrent access by multiple processes, and utilize parallelism in the I/O system to improve performance. Parallel files can also be used conventionally by sequential programs. A set of standard parallel file organizations is proposed, organizations are suggested, using multiple storage devices. Problem areas are also identified and discussed.

  7. Mod I automotive Stirling engine mechanical development

    SciTech Connect

    Simetkosky, M.

    1984-01-01

    The Mod I Stirling engine was the first automotive Stirling engine designed specifically for automotive application. Testing of these engines has revealed several deficiencies in engine mechanical integrity which have been corrected by redesign or upgrade. The main deficiencies uncovered during the Mod I program lie in the combustion, auxiliary, main seal, and heater head areas. This paper will address each of the major area deficiencies in detail, and describe the corrective actions taken as they apply to the Mod I and the next Stirling-engine design, the Upgraded Mod I (a redesign to incorporate new materials for cost/weight reduction and improved performance).

  8. Trilinos I/O Support (Trios)

    DOE PAGESBeta

    Oldfield, Ron A.; Sjaardema, Gregory D.; Lofstead II, Gerald F.; Kordenbrock, Todd

    2012-01-01

    Trilinos I/O Support (Trios) is a new capability area in Trilinos that serves two important roles: (1) it provides and supports I/O libraries used by in-production scientific codes; (2) it provides a research vehicle for the evaluation and distribution of new techniques to improve I/O on advanced platforms. This paper provides a brief overview of the production-grade I/O libraries in Trios as well as some of the ongoing research efforts that contribute to the experimental libraries in Trios.

  9. Search for a pentaquark decaying to <i>pK>0S in <i>γN>

    SciTech Connect

    Link, J. M.; Yager, P. M.; Anjos, J. C.; Bediaga, I.; Castromonte, C.; Machado, A. A.; Magnin, J.; Massafferri, A.; de Miranda, J. M.; Pepe, I. M.; Polycarpo, E.; dos Reis, A. C.; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sánchez-Hernández, A.; Uribe, C.; Vázquez, F.; Agostino, L.; Cinquini, L.; Cumalat, J. P.; Frisullo, V.; O'Reilly, B.; Segoni, I.; Stenson, K.; Butler, J. N.; Cheung, H. W. K.; Chiodini, G.; Gaines, I.; Garbincius, P. H.; Garren, L. A.; Gottschalk, E.; Kasper, P. H.; Kreymer, A. E.; Kutschke, R.; Wang, M.; Benussi, L.; Bertani, M.; Bianco, S.; Fabbri, F. L.; Pacetti, S.; Zallo, A.; Reyes, M.; Cawlfield, C.; Kim, D. Y.; Rahimi, A.; Wiss, J.; Gardner, R.; Kryemadhi, A.; Chung, Y. S.; Kang, J. S.; Ko, B. R.; Kwak, J. W.; Lee, K. B.; Cho, K.; Park, H.; Alimonti, G.; Barberis, S.; Boschini, M.; Cerutti, A.; D'Angelo, P.; DiCorato, M.; Dini, P.; Edera, L.; Erba, S.; Inzani, P.; Leveraro, F.; Malvezzi, S.; Menasce, D.; Mezzadri, M.; Moroni, L.; Pedrini, D.; Pontoglio, C.; Prelz, F.; Rovere, M.; Sala, S.; Davenport, T. F.; Arena, V.; Boca, G.; Bonomi, G.; Gianini, G.; Liguori, G.; Lopes Pegna, D.; Merlo, M. M.; Pantea, D.; Ratti, S. P.; Riccardi, C.; Vitulo, P.; Göbel, C.; Olatora, J.; Hernandez, H.; Lopez, A. M.; Mendez, H.; Paris, A.; Quinones, J.; Ramirez, J. E.; Zhang, Y.; Wilson, J. R.; Handler, T.; Mitchell, R.; Engh, D.; Givens, K. M.; Hosack, M.; Johns, W. E.; Luiggi, E.; Nehring, M.; Sheldon, P. D.; Vaandering, E. W.; Webster, M.; Sheaff, M.

    2006-08-01

    We present a search for a pentaquark decaying strongly to <i>pK>0S in <i>γN> collisions at a center-of-mass energy up to 25 GeV/c2. Finding no evidence for such a state in the mass range of 1470 MeV/c2 to 2200 MeV/c2, we set limits on the yield and on the cross section times branching ratio relative to Σ* (1385)± and K* (892) +.

  10. Recurrent thyrotoxicosis after I-131 induced hypothyroidism

    SciTech Connect

    Liu, L.; Borowski, G.D.; Shtasel, P.; Rose, L.I.

    1984-01-01

    The first clinically and biochemically documented case of recurrent thyrotoxicosis after I-131 induced hypothyroidism in a patient with Graves' disease is reported. Two months after the administration of 9.2 mCi of I-131, the subject developed hypothyroidism. One month later, the patient became euthyroid. Then, nine months following ablation, the patient again developed thyrotoxicosis. A second dose of I-131 of 12.5 mCi was required to finally produce permanent hypothyroidism. This case illustrates the recurrence of hypothyroidism after what had seemed to have been adequate I-131 radiation.

  11. Electronic structure, transport, and phonons of SrAg<i>Ch>F (<i>Ch> = S,Se,Te): Bulk superlattice thermoelectrics

    SciTech Connect

    Gudelli, Vijay Kumar; Kanchana, V.; Vaitheeswaran, G.; Singh, David J.; Svane, Axel; Christensen, Niels Egede; Mahanti, Subhendra D.

    2015-07-15

    Here, we report calculations of the electronic structure, vibrational properties, and transport for the p-type semiconductors, SrAg<i>Ch>F (<i>Ch> = S, Se, and Te). We find soft phonons with low frequency optical branches intersecting the acoustic modes below 50 cm–1, indicative of a material with low thermal conductivity. The bands at and near the valence-band maxima are highly two-dimensional, which leads to high thermopowers even at high carrier concentrations, which is a combination that suggests good thermoelectric performance. These materials may be regarded as bulk realizations of superlattice thermoelectrics.

  12. I-ball formation with logarithmic potential

    SciTech Connect

    Kawasaki, Masahiro; Takeda, Naoyuki E-mail: takedan@icrr.u-tokyo.ac.jp

    2014-07-01

    A coherently oscillating real scalar field with potential shallower than quadratic one fragments into spherical objects called I-balls. We study the I-ball formation for logarithmic potential which appears in many cosmological models. We perform lattice simulations and find that the I-balls are formed when the potential becomes dominated by the quadratic term. Furthermore, we estimate the I-ball profile assuming that the adiabatic invariant is conserved during formation and obtain the result that agrees to the numerical simulations.

  13. Ares I-X Flight Test Vehicle similitude to the Ares I Crew Launch Vehicle

    NASA Astrophysics Data System (ADS)

    Huebner, Lawrence D.; Smith, R. Marshall; Campbell, John R.; Taylor, Terry L.

    2009-12-01

    The Ares I-X Flight Test Vehicle is the first in a series of flight test vehicles that will take the Ares I Crew Launch Vehicle design from development to operational capability. Ares I-X is scheduled for a 2009 flight date, early enough in the Ares I design and development process so that data obtained from the flight can impact the design of Ares I before its Critical Design Review. Decisions on Ares I-X scope, flight test objectives, and FTV fidelity were made prior to the Ares I systems requirements being baselined. This was necessary in order to achieve a development flight test to impact the Ares I design. Differences between the Ares I-X and the Ares I configurations are artifacts of formulating this experimental project at an early stage and the natural maturation of the Ares I design process. This paper describes the similarities and differences between the Ares I-X Flight Test Vehicle and the Ares I Crew Launch Vehicle. Areas of comparison include the outer mold line geometry, aerosciences, trajectory, structural modes, flight control architecture, separation sequence, and relevant element differences. Most of the outer mold line differences present between Ares I and Ares I-X are minor and will not have a significant effect on overall vehicle performance. The most significant impacts are related to the geometric differences in Orion Crew Exploration Vehicle at the forward end of the stack. These physical differences will cause differences in the flow physics in these areas. Even with these differences, the Ares I-X flight test is poised to meet all five primary objectives and six secondary objectives. Knowledge of what the Ares I-X flight test will provide in similitude to Ares I—as well as what the test will not provide—is important in the continued execution of the Ares I-X mission leading to its flight and the continued design and development of Ares I.

  14. Antitumor Activity of Gold(I), Silver(I) and Copper(I) Complexes Containing Chiral Tertiary Phosphines

    PubMed Central

    McKeage, Mark J.; Papathanasiou, Peter; Sjaarda, Allan; Swiegers, Gerhard F.; Waring, Paul; Wild, S. Bruce

    1998-01-01

    The in vitro cytotoxicities of a number of gold(I), silver(I) and copper(I) complexes containing chiral tertiary phosphine ligands have been examined against the mouse tumour cell lines P815 mastocytoma, B16 melanoma [gold(I) and silver(I) compounds] and P388 leukaemia [gold(I) complexes only] with many of the complexes having IC50 values comparable to that of the reference compounds cis-diamminedichloroplatinum(ll), cisplatin, and bis[1,2-bis(diphenylphosphino) ethane]gold(I) iodide. The chiral tertiary phosphine ligands used in this study include (R)-(2-aminophenyl)methylphenylphosphine; (R,R)-, (S,S)- and (R*,R*)-1,2-phenylenebis(methylphenylphosphine); and (R,R)-, (S,S)- and (R*,R*)-bis{(2-diphenylphosphinoethyl)phenylphosphino}ethane. The in vitro cytotoxicities of gold(I) and silver(I) complexes containing the optically active forms of the tetra(tertiary phosphine) have also been examined against the human ovarian carcinoma cell lines 41M and CH1, and the cisplatin resistant 41McisR, CH1cisR and SKOV-3 tumour models. IC50 values in the range 0.01 - 0.04 μM were determined for the most active compounds, silver(I) complexes of the tetra(tertiary phosphine). Furthermore, the chirality of the ligand appeared to have little effect on the overall activity of the complexes: similar IC50 data were obtained for complexes of a particular metal ion with each of the stereoisomeric forms of a specific ligand. PMID:18475846

  15. Ag(I)-binding to phytochelatins.

    PubMed

    Mehra, R K; Tran, K; Scott, G W; Mulchandani, P; Saini, S S

    1996-02-01

    Phytochelatins (PCs) are glutathione-derived peptides with the general structure (gamma-Glu-Cys)nGly, where n varies from 2 to 11. A variety of metal ions such as Cu(II), Cd(II), Pb(II), Zn(II), and Ag(I) induce PC synthesis in plants and some yeasts. It has generally been assumed that the inducer metals also bind PCs. However, very little information is available on the binding of metals other than Cu(I) and Cd(II) to PCs. In this paper, we describe the Ag(I)-binding characteristics of PCs with the structure (gamma-Glu-Cys)2Gly, (gamma-Glu-Cys)3Gly, and (gamma-Glu-Cys)4Gly. The Ag(I)-binding stoichiometries of these three peptides were determined by (i) UV/VIS spectrophotometry, (ii) luminescence spectroscopy at 77 K, and (iii) reverse-phase HPLC. The three techniques yielded similar results. ApoPCs exhibit featureless absorption in the 220-340 nm range. The binding of Ag(I) to PCs induced the appearance of specific absorption shoulders. The titration end point was indicated by the flattening of the characteristic absorption shoulders. Similarly, luminescence at 77 K due to Ag(I)-thiolate clusters increased with the addition of graded Ag(I) equivalents. The luminescence declined when Ag(I) equivalents in excess of the saturating amounts were added to the peptides. At neutral pH, (gamma-Glu-Cys)2Gly, (gamma-Glu-Cys)3Gly, and (gamma-Glu-Cys)4Gly bind 1.0, 1.5, and 4.0 equivalents of Ag(I), respectively. The Ag(I)-binding capacity of (gamma-Glu-Cys)2Gly and (gamma-Glu-Cys)3Gly was increased at pH 5.0 and below so that Ag(I)/-SH ratio approached 1.0. A similar pH-dependent binding of Ag(I) to glutathione was also observed. The increased Ag(I)-binding to PCs at lower pH is of physiological significance as these peptides accumulate in acidic vacuoles. We also report lifetime data on Ag(I)-PCs. The relatively long decay-times (approximately 0.1-0.3 msec) accompanied with a large Stokes shift in the emission band are indicative of spin-forbidden phosphorescence. PMID

  16. Title I Dollars Support Community Schools

    ERIC Educational Resources Information Center

    Pearson, Sarah S.; Blank, Martin J.

    2010-01-01

    Title I funds are available to districts and schools with high numbers or percentages of disadvantaged students to provide services, including academic enrichment services through Title I, Part A, so all the nation's children have an equal opportunity to education and can reach proficiency on state academic achievement standards and assessments.…

  17. The I-Search: Writing to Learn

    ERIC Educational Resources Information Center

    Crouse-Powers, Amy

    2006-01-01

    For a college study strategies course, we utilized Macrorie's (1988) I-Search process to facilitate students' individual exploration of the typical "study skills" issues that such a course would cover. The I-Search promotes active reflection, evaluation, and synthesis, and is an excellent tool both for aiding students in learning new…

  18. 10 CFR 205.199I - Remedies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Remedies. 205.199I Section 205.199I Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Notice of Probable Violation, Remedial Order, Notice... person to whom it is directed to roll back prices, to make refunds equal to the amount (plus...

  19. 10 CFR 205.199I - Remedies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Remedies. 205.199I Section 205.199I Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Notice of Probable Violation, Remedial Order, Notice... person to whom it is directed to roll back prices, to make refunds equal to the amount (plus...

  20. What's Your Stroke I.Q.?

    MedlinePlus

    What's Your Stroke I.Q.? Often, it is believed that stroke is a disease of old age. You may be surprised to learn that stroke ... to help prevent it. Test your stroke I.Q. by answering these six questions. By knowing the ...

  1. 10 CFR 205.199I - Remedies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Remedies. 205.199I Section 205.199I Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Notice of Probable Violation, Remedial Order, Notice... person to whom it is directed to roll back prices, to make refunds equal to the amount (plus...

  2. Connect the Book. I Face the Wind

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2005-01-01

    This month's feature is Vicki Cobb's "I Face the Wind" (Illus. by Julia Gorton. HarperCollins, 2003) which introduces the wind's characteristics and actions through experiments and observations complemented with Gorton's creative illustrations. "I Face the Wind" was a 2004 Sibert Honor Book. The Sibert Award and Honor books are awarded annually to…

  3. Synthesis and Bioactivity of Luffarin I

    PubMed Central

    Urosa, Aitor; Marcos, Isidro S.; Díez, David; Lithgow, Anna; Plata, Gabriela B.; Padrón, José M.; Basabe, Pilar

    2015-01-01

    The first synthesis of Luffarin I, sesterterpenolide isolated from sponge Luffariella geometrica, has been accomplished from commercially available sclareol. The key strategy involved in this synthesis is the diastereoselective reduction of an intermediate ketone. Luffarin I against human solid tumor cell lines showed antiproliferative activities (GI50) in the range 12–17 μM. PMID:25903281

  4. Learning Chinese Idioms through iPads

    ERIC Educational Resources Information Center

    Yang, Chunsheng; Xie, Ying

    2013-01-01

    This paper reports on an action research study using iPads during the teaching of Chinese idioms to heritage learners. A class of 12 second-year Chinese learners were engaged in a self-generated learning process focused on learning abstract and concrete idioms using iPads. Students' short-term and long-term learning was measured; feedback…

  5. Listening Habits of iPod Users

    ERIC Educational Resources Information Center

    Epstein, Michael; Marozeau, Jeremy; Cleveland, Sandra

    2010-01-01

    Purpose: To estimate real-environment iPod listening levels for listeners in 4 environments to gain insight into whether average listeners receive dosages exceeding occupational noise exposure guidelines as a result of their listening habits. Method: The earbud outputs of iPods were connected directly into the inputs of a digital recorder to make…

  6. FOUNDATIONS OF THAI. BOOK I, PART 1.

    ERIC Educational Resources Information Center

    ANTHONY, EDWARD M.; AND OTHERS

    THIS BEGINNING TEXT PRESENTS THE ESSENTIALS OF THAI PRONUNCIATION AND GRAMMAR IN A FORMAT GEARED TO REGULAR COLLEGE LANGUAGE COURSE SCHEDULING. THE COURSE CONSISTS OF TWO VOLUMES, BOOK I, PART 1 (LESSONS 1-14) AND BOOK I, PART 2 (LESSONS 15-25), PROVIDING MATERIAL FOR TWO UNIVERSITY SEMESTERS OF CLASSROOM AND LABORATORY WORK. BASED ON A…

  7. Ares I First Stage: Powering Exploration

    NASA Technical Reports Server (NTRS)

    Tiller, Bruce K.

    2009-01-01

    I. Ares First Stage design is on schedule. a) Avionics; b) Major Structures; c) Motor; and d) Deceleration System II. Ares I-X hardware is complete and assembly at KSC is underway. Launch scheduled for October 31. III. Recovery system testing is on schedule a) Drogue; b) Main chute; and c) Cluster. DM-1 static firing is scheduled for August 25, 2009

  8. Benzo[g,h,i]perylene

    Integrated Risk Information System (IRIS)

    Benzo [ g , h , i ] perylene ; CASRN 191 - 24 - 2 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Nonc

  9. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FINANCIAL PROTECTION REQUIREMENTS AND INDEMNITY AGREEMENTS Violations Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance...

  10. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FINANCIAL PROTECTION REQUIREMENTS AND INDEMNITY AGREEMENTS Violations Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance...

  11. Complete genome sequence of <i>Bacillus amyloliquefaciensi> strain Co1-6, a plant growth-promoting rhizobacterium of <i>Calendula officinalisi>

    SciTech Connect

    Köberl, Martina; White, Richard A.; Erschen, Sabine; Spanberger, Nora; El-Arabi, Tarek F.; Jansson, Janet K.; Berg, Gabriele

    2015-08-13

    The genome sequence of <i>Bacillus amyloliquefaciensi> strain Co1-6, a plant growth-promoting rhizobacterium (PGPR) with broad-spectrum antagonistic activity against plant-pathogenic fungi, bacteria, and nematodes, consists of a single 3.9-Mb circular chromosome. The genome reveals genes putatively responsible for its promising biocontrol and PGP properties.

  12. Echinacea: What Should I Know about It?

    MedlinePlus

    ... Web version Echinacea: What Should I Know About It? Echinacea: What Should I Know About It? What is echinacea? Echinacea (say: "eck-in-ay- ... take echinacea on an empty stomach. Instead, take it with food or a large glass of water. ...

  13. In iPod We Trust

    ERIC Educational Resources Information Center

    Blaisdell, Mikael

    2006-01-01

    Beloved by students worldwide, iPod is becoming a presence in the classroom as teachers discover its many educational uses. At heart, the iPod's appeal is about its easily accessible audio and visual content in an attractive and conveniently sized package. Mechanically, the product is mostly a hard disk drive (although some models use only flash…

  14. British I.T.A. Research.

    ERIC Educational Resources Information Center

    Downing, John

    1968-01-01

    The conclusions and recommendations drawn from a 7-year study of the Initial Teaching Alphabet (i/t/a) made by the Reading Research Unit of London University are reported. The British research showed conclusively that traditional orthography (TO) is a major handicap for teachers and students of reading. Students taught with i/t/a made…

  15. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR... Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance (Secondary Financial Protection) Named Insured: Each person...

  16. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR... Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance (Secondary Financial Protection) Named Insured: Each person...

  17. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR... Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance (Secondary Financial Protection) Named Insured: Each person...

  18. Sports participation with Chiari I malformation.

    PubMed

    Strahle, Jennifer; Geh, Ndi; Selzer, Béla J; Bower, Regina; Himedan, Mai; Strahle, MaryKathryn; Wetjen, Nicholas M; Muraszko, Karin M; Garton, Hugh J L; Maher, Cormac O

    2016-04-01

    OBJECT There is currently no consensus on the safety of sports participation for patients with Chiari I malformation (CM-I). The authors' goal was to define the risk of sports participation for children with the imaging finding of CM-I. METHODS A prospective survey was administered to 503 CM-I patients at 2 sites over a 46-month period. Data were gathered on imaging characteristics, treatment, sports participation, and any sport-related injuries. Additionally, 81 patients completed at least 1 subsequent survey following their initial entry into the registry and were included in a prospective group, with a mean prospective follow-up period of 11 months. RESULTS Of the 503 CM-I patients, 328 participated in sports for a cumulative duration of 4641 seasons; 205 of these patients participated in contact sports. There were no serious or catastrophic neurological injuries. One patient had temporary extremity paresthesias that resolved within hours, and this was not definitely considered to be related to the CM-I. In the prospective cohort, there were no permanent neurological injuries. CONCLUSIONS No permanent or catastrophic neurological injuries were observed in CM-I patients participating in athletic activities. The authors believe that the risk of such injuries is low and that, in most cases, sports participation by children with CM-I is safe. PMID:26636249

  19. Taking the iPad's Measure

    ERIC Educational Resources Information Center

    Raths, David

    2012-01-01

    Soon after the iPad's release in 2010, several universities decided to issue the devices to all incoming freshmen. At the time, critics scoffed at the moves as little more than marketing gimmicks designed to attract students. In truth, few of the schools required instructors to design curriculum around the iPad or had specific plans to measure…

  20. Tobacco Addiction: 'Why Do I Smoke?' Quiz

    MedlinePlus

    MENU Return to Web version Tobacco Addiction | “Why do I smoke?" Quiz Why do I smoke? If you learn the answer to this question, it will be easier to ... m hooked." In addition to having a psychological addiction to smoking, you may also be physically addicted ...

  1. First Graders with iPads?

    ERIC Educational Resources Information Center

    Getting, Sara; Swainey, Karin

    2012-01-01

    Giving iPads to first graders is a leap of faith that many teachers are understandably hesitant to take, especially if their students need immediate reading intervention and school leaders want guaranteed results. This article discusses how the authors took on the challenge of improving elementary reading using iPads, found surprising success for…

  2. iTOUGH2 Sample Problems

    SciTech Connect

    Finsterle, Stefan

    2002-06-18

    iTOUGH2 is a program for parameter estimation, sensitivity analysis, and uncertainty propagation analysis. It is based on the TOUGH2 simulator for non-isothermal multiphase flow in fractured and porous media. This report contains a collection of iTOUGH2 sample problems.

  3. Synthesis and bioactivity of Luffarin I.

    PubMed

    Urosa, Aitor; Marcos, Isidro S; Díez, David; Lithgow, Anna; Plata, Gabriela B; Padrón, José M; Basabe, Pilar

    2015-04-01

    The first synthesis of Luffarin I, sesterterpenolide isolated from sponge Luffariella geometrica, has been accomplished from commercially available sclareol. The key strategy involved in this synthesis is the diastereoselective reduction of an intermediate ketone. Luffarin I against human solid tumor cell lines showed antiproliferative activities (GI50) in the range 12-17 μM. PMID:25903281

  4. How Can I Deal with My Asthma?

    MedlinePlus

    ... Who Cuts? How Can I Deal With My Asthma? KidsHealth > For Teens > How Can I Deal With My Asthma? Print A A A Text Size What's in ... Tips en español ¿Cómo puedo afrontar mi asma? Asthma is more common these days than it used ...

  5. iPods: Informative or Invasive?

    ERIC Educational Resources Information Center

    French, Donald P.

    2006-01-01

    In this article, the author discusses how iPods are being used in a variety of teacher-centered and student-centered ways. Since today's students are characterized as social, highly competent multitaskers, who expect immediate results and feedback and seek stimulation and interaction, iPod and podcasting are seen as tools for teaching such…

  6. Learning English with iPods

    ERIC Educational Resources Information Center

    Lacina, Jan

    2008-01-01

    Across the world, technology is part of the social and academic lives of students. In particular, iPods are one of the most popular forms of technology. Wikipedia, an excellent online source for information, notes that Apple has sold more than 119 million of these portable media players as of October 2007. With iPods, students can listen to, or…

  7. iTOUGH2 Command Reference

    SciTech Connect

    Finsterle, Stefan

    2002-06-18

    iTOUGH2 is a program for parameter estimation, sensitivity analysis, and uncertainty propagation analysis. It is based on the TOUGH2 simulator for non-isothermal multiphase flow in fractured and porous media. This report contains a detailed description of all iTOUGH2 commands.

  8. Investigation of structural heterogeneity at the SPE site using combined <i>P>–wave travel times and <i>Rg> phase velocities

    SciTech Connect

    Rowe, Charlotte A.; Patton, Howard J.

    2015-10-01

    Here, we present analyses of the 2D seismic structure beneath Source Physics Experiments (SPE) geophone lines that extended radially at 100 m spacing from 100 to 2000 m from the source borehole. With seismic sources at only one end of the geophone lines, standard refraction profiling methods cannot resolve seismic velocity structures unambiguously. In previous work, we demonstrated overall agreement between body-wave refraction modeling and <i>Rg> dispersion curves for the least complex of the five lines. A more detailed inspection supports a 2D reinterpretation of the structure. We obtained <i>Rg> phase velocity measurements in both the time and frequency domains, then used iterative adjustment of the initial 1D body-wave model to predict <i>Rg> dispersion curves to fit the observed values. Our method applied to the most topographically severe of the geophone lines is supplemented with a 2D ray-tracing approach, whose application to P-wave arrivals supports the <i>Rg> analysis. In addition, midline sources will allow us to refine our characterization in future work.

  9. Using iPads to Your Advantage

    ERIC Educational Resources Information Center

    Zakrzewski, Jennifer L.

    2016-01-01

    In this article, middle school mathematics teacher Jennifer Zakrzewski describes how she successfully incorporated iPads and Apple TV (for projection of iPad screens) into her classroom while having her students solve a problem about mangoes. As Zakrzewski began a unit on multiplying and dividing fractions, she chose to start with the Mangoes…

  10. Great Expectations: Understanding the New Title I.

    ERIC Educational Resources Information Center

    Manasevit, Leigh M.; Cowan, Kristen Tosh

    On October 20, 1994, President Clinton signed into law the Improving America's Schools Act of 1994. This statute contains amendments to the Elementary and Secondary Education Act of 1965, including the reauthorization of Chapter 1, as the newly entitled Title I. The reauthorized Title I drastically restructures the direction of former remedial…

  11. Structural, functional and immunogenic insights on Cu,Zn superoxide dismutase pathogenic virulence factors from <i>Neisseria meningitidisi> and <i>Brucella abortusi>

    SciTech Connect

    Pratt, Ashley J.; DiDonato, Michael; Shin, David S.; Cabelli, Diane E.; Bruns, Cami K.; Belzer, Carol A.; Gorringe, Andrew R.; Langford, Paul R.; Tabatabai, Louisa B.; Kroll, J. Simon; Tainer, John A.; Getzoff, Elizabeth D.

    2015-10-12

    Bacterial pathogens <i>Neisseria meningitidisi> and <i>Brucella abortusi> pose threats to human and animal health worldwide, causing meningococcal disease and brucellosis, respectively. Mortality from acute <i>N. meningitidisi> infections remains high despite antibiotics, and brucellosis presents alimentary and health consequences. Superoxide dismutases are master regulators of reactive oxygen, general pathogenicity factors and therefore therapeutic targets. Cu,Zn superoxide dismutases (SODs) localized to the periplasm promote survival by detoxifying superoxide radicals generated by major host antimicrobial immune responses. We discovered that passive immunization with an antibody directed at <i>N. meningitidisi> SOD (NmSOD) was protective in a mouse infection model. To define the relevant atomic details and solution assembly states of this important virulence factor, we report high-resolution and X-ray scattering analyses of NmSOD and SOD from <i>B. abortusi> (BaSOD). The NmSOD structures revealed an auxiliary tetrahedral Cu-binding site bridging the dimer interface; mutational analyses suggested that this metal site contributes to protein stability, with implications for bacterial defense mechanisms. Biochemical and structural analyses informed us about electrostatic substrate guidance, dimer assembly and an exposed C-terminal epitope in the NmSOD dimer. In contrast, the monomeric BaSOD structure provided insights for extending immunogenic peptide epitopes derived from the protein. These collective results reveal unique contributions of SOD to pathogenic virulence, refine predictive motifs for distinguishing SOD classes and suggest general targets for anti-bacterial immune responses. The identified functional contributions, motifs, and targets distinguishing bacterial and eukaryotic SOD assemblies presented here provide a foundation for efforts to develop SOD-specific inhibitors or vaccines against these harmful pathogens.

    IMPORTANCE By

  12. Molecular simulation and modeling of complex I.

    PubMed

    Hummer, Gerhard; Wikström, Mårten

    2016-07-01

    Molecular modeling and molecular dynamics simulations play an important role in the functional characterization of complex I. With its large size and complicated function, linking quinone reduction to proton pumping across a membrane, complex I poses unique modeling challenges. Nonetheless, simulations have already helped in the identification of possible proton transfer pathways. Simulations have also shed light on the coupling between electron and proton transfer, thus pointing the way in the search for the mechanistic principles underlying the proton pump. In addition to reviewing what has already been achieved in complex I modeling, we aim here to identify pressing issues and to provide guidance for future research to harness the power of modeling in the functional characterization of complex I. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26780586

  13. Humanin: Functional Interfaces with IGF-I.

    PubMed

    Xiao, J; Kim, S-J; Cohen, P; Yen, K

    2016-08-01

    Humanin is the first newly discovered peptide encoded in the mitochondrial genome in over three decades. It is the first member of a novel class of mitochondrial derived peptides. This small, 24 amino acid peptide was initially discovered to have neuroprotective effects and subsequent experiments have shown that it is beneficial in a diverse number of disease models including stroke, cardiovascular disease, and cancer. Over a decade ago, our lab found that humanin bound IGFBP-3 and more recent studies have found it to decrease circulating IGF-I levels. In turn, IGF-I also seems to regulate humanin levels and in this review, we cover the known interaction between humanin and IGF-I. Although the exact mechanism for how humanin and IGF-I regulate each other still needs to be elucidated, it is clear that humanin is a new player in IGF-I signaling. PMID:27082450

  14. Complex I function in mitochondrial supercomplexes.

    PubMed

    Lenaz, Giorgio; Tioli, Gaia; Falasca, Anna Ida; Genova, Maria Luisa

    2016-07-01

    This review discusses the functional properties of mitochondrial Complex I originating from its presence in an assembled form as a supercomplex comprising Complex III and Complex IV in stoichiometric ratios. In particular several lines of evidence are presented favouring the concept that electron transfer from Complex I to Complex III is operated by channelling of electrons through Coenzyme Q molecules bound to the supercomplex, in contrast with the hypothesis that the transfer of reducing equivalents from Complex I to Complex III occurs via random diffusion of the Coenzyme Q molecules in the lipid bilayer. Furthermore, another property provided by the supercomplex assembly is the control of generation of reactive oxygen species by Complex I. This article is part of a Special Issue entitled Respiratory Complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26820434

  15. The life of plant mitochondrial complex I.

    PubMed

    Braun, Hans-Peter; Binder, Stefan; Brennicke, Axel; Eubel, Holger; Fernie, Alisdair R; Finkemeier, Iris; Klodmann, Jennifer; König, Ann-Christine; Kühn, Kristina; Meyer, Etienne; Obata, Toshihiro; Schwarzländer, Markus; Takenaka, Mizuki; Zehrmann, Anja

    2014-11-01

    The mitochondrial NADH dehydrogenase complex (complex I) of the respiratory chain has several remarkable features in plants: (i) particularly many of its subunits are encoded by the mitochondrial genome, (ii) its mitochondrial transcripts undergo extensive maturation processes (e.g. RNA editing, trans-splicing), (iii) its assembly follows unique routes, (iv) it includes an additional functional domain which contains carbonic anhydrases and (v) it is, indirectly, involved in photosynthesis. Comprising about 50 distinct protein subunits, complex I of plants is very large. However, an even larger number of proteins are required to synthesize these subunits and assemble the enzyme complex. This review aims to follow the complete "life cycle" of plant complex I from various molecular perspectives. We provide arguments that complex I represents an ideal model system for studying the interplay of respiration and photosynthesis, the cooperation of mitochondria and the nucleus during organelle biogenesis and the evolution of the mitochondrial oxidative phosphorylation system. PMID:24561573

  16. A guided-ion beam study of the collisions and reactions of I+ and I 2+ with I2

    NASA Astrophysics Data System (ADS)

    Hause, Michael L.; Prince, Benjamin D.; Bemish, Raymond J.

    2015-02-01

    Growing interest in developing and testing iodine Hall effect thrusters requires measurements of the cross sections of reactions that generate low energy plasma following discharge. Limited experimental and theoretical work necessitates a decisive experiment to elucidate the charge exchange and collision-induced dissociation channels. To this end, we have used guided-ion beam techniques to measure cross sections for both I+ + I2 and I2 + + I 2 collisions. We present total collision cross sections as well as collision-induced dissociation cross sections for center-of-mass collision energies ranging from 0.5 to 200 eV for molecular iodine cations. Similarly, we present total collision cross section and charge-exchange cross sections for atomic iodine cations for center-of-mass collision energies ranging from 0.67 to 167 eV. Time-of-flight measurements of the collision products allow determination of velocity distributions, which show evidence of complex formation of I3 + from the I+ + I2 reaction at collision energies below 6 eV.

  17. A guided-ion beam study of the collisions and reactions of I(+) and I2 (+) with I2.

    PubMed

    Hause, Michael L; Prince, Benjamin D; Bemish, Raymond J

    2015-02-21

    Growing interest in developing and testing iodine Hall effect thrusters requires measurements of the cross sections of reactions that generate low energy plasma following discharge. Limited experimental and theoretical work necessitates a decisive experiment to elucidate the charge exchange and collision-induced dissociation channels. To this end, we have used guided-ion beam techniques to measure cross sections for both I(+) + I2 and I2 (+)+I2 collisions. We present total collision cross sections as well as collision-induced dissociation cross sections for center-of-mass collision energies ranging from 0.5 to 200 eV for molecular iodine cations. Similarly, we present total collision cross section and charge-exchange cross sections for atomic iodine cations for center-of-mass collision energies ranging from 0.67 to 167 eV. Time-of-flight measurements of the collision products allow determination of velocity distributions, which show evidence of complex formation of I3 (+) from the I(+) + I2 reaction at collision energies below 6 eV. PMID:25702009

  18. VUV Photofragmentation of CH2I2: The [CH2I-I](•+) Iso-diiodomethane Intermediate in the I-Loss Channel from [CH2I2](•.).

    PubMed

    Cartoni, Antonella; Casavola, Anna Rita; Bolognesi, Paola; Borocci, Stefano; Avaldi, Lorenzo

    2015-04-23

    Diiodomethane is an important halocarbon responsible for several atmospheric processes like ozone depletion and aerosol particle formation. Despite this, the thermochemical data and a detailed analysis of the pathways for the decomposition of this halomethane and its molecular ion [CH2I2](•+) are scarce. In this paper an investigation of the photodissociation dynamics of the CH2I2 molecule focused on the I-loss channel by the photoelectron-photoion coincidence (PEPICO) technique and computational methods is reported. The experimental results show that upon VUV irradiation the dissociation of the lower electronic ionic states of diiodomethane leads only to the CH2I(+) ion and the I atom. The theoretical calculations point out that isomerization of [CH2I2](•+) into iso-diiodomethane [CH2I-I](•+) may play an important role in the emission of iodine atom as compared to direct C-I bond breaking. PMID:25866871

  19. Mitochondrial complex I-linked disease.

    PubMed

    Rodenburg, Richard J

    2016-07-01

    Complex I deficiency is the most frequently encountered single mitochondrial single enzyme deficiency in patients with a mitochondrial disorder. Although specific genotype-phenotype correlations are very difficult to identify, the majority of patients present with symptoms caused by leukodystrophy. The poor genotype-phenotype correlations can make establishing a diagnosis a challenge. The classical way to establish a complex I deficiency in patients is by performing spectrophotometric measurements of the enzyme in a muscle biopsy or other patient-derived material (liver or heart biopsy, cultured skin fibroblasts). Complex I is encoded by both the mtDNA and nuclear DNA and pathogenic mutations have been identified in the majority of the 44 genes encoding the structural subunits of complex I. In recent years, the increasing possibilities for diagnostic molecular genetic tests of large gene panels, exomes, and even entire genomes has led to the identification of many novel genetic defects causing complex I deficiency. Complex I mutations not only result in a reduced enzyme activity but also induce secondary effects at the cellular level, such as elevated reactive oxygen species production, altered membrane potential and mitochondrial morphology. At this moment there is no cure for complex I deficiency and the treatment options for complex I patients are restricted to symptomatic treatment. Recent developments, amongst others based on the treatment of the secondary effects of complex I deficiency, have shown to be promising as new therapeutic strategies in vitro and have entered clinical trials. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26906428

  20. RIG-I in RNA virus recognition.

    PubMed

    Kell, Alison M; Gale, Michael

    2015-05-01

    Antiviral immunity is initiated upon host recognition of viral products via non-self molecular patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition initiates signaling cascades that induce intracellular innate immune defenses and an inflammatory response that facilitates development of the acquired immune response. The retinoic acid-inducible gene I (RIG-I) and the RIG-I-like receptor (RLR) protein family are key cytoplasmic pathogen recognition receptors that are implicated in the recognition of viruses across genera and virus families, including functioning as major sensors of RNA viruses, and promoting recognition of some DNA viruses. RIG-I, the charter member of the RLR family, is activated upon binding to PAMP RNA. Activated RIG-I signals by interacting with the adapter protein MAVS leading to a signaling cascade that activates the transcription factors IRF3 and NF-κB. These actions induce the expression of antiviral gene products and the production of type I and III interferons that lead to an antiviral state in the infected cell and surrounding tissue. RIG-I signaling is essential for the control of infection by many RNA viruses. Recently, RIG-I crosstalk with other pathogen recognition receptors and components of the inflammasome has been described. In this review, we discuss the current knowledge regarding the role of RIG-I in recognition of a variety of virus families and its role in programming the adaptive immune response through cross-talk with parallel arms of the innate immune system, including how RIG-I can be leveraged for antiviral therapy. PMID:25749629

  1. RIG-I in RNA virus recognition

    PubMed Central

    Kell, Alison M.; Gale, Michael

    2015-01-01

    Antiviral immunity is initiated upon host recognition of viral products via non-self molecular patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition initiates signaling cascades that induce intracellular innate immune defenses and an inflammatory response that facilitates development of the acquired immune response. The retinoic acid-inducible gene I (RIG-I) and the RIG-I-like receptor (RLR) protein family are key cytoplasmic pathogen recognition receptors that are implicated in the recognition of viruses across genera and virus families, including functioning as major sensors of RNA viruses, and promoting recognition of some DNA viruses. RIG-I, the charter member of the RLR family, is activated upon binding to PAMP RNA. Activated RIG-I signals by interacting with the adapter protein MAVS leading to a signaling cascade that activates the transcription factors IRF3 and NF-κB. These actions induce the expression of antiviral gene products and the production of type I and III interferons that lead to an antiviral state in the infected cell and surrounding tissue. RIG-I signaling is essential for the control of infection by many RNA viruses. Recently, RIG-I crosstalk with other pathogen recognition receptors and components of the inflammasome has been described. In this review, we discuss the current knowledge regarding the role of RIG-I in recognition of a variety of virus families and its role in programming the adaptive immune response through cross-talk with parallel arms of the innate immune system, including how RIG-I can be leveraged for antiviral therapy. PMID:25749629

  2. 7 CFR 170.7 - Can I apply if I am not recruited?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... UNDER THE AGRICULTURAL MARKETING ACT OF 1946 USDA FARMERS MARKET § 170.7 Can I apply if I am not... Avenue, SW., Washington, DC, 20250, or call (202) 720-8317. They may also call the USDA Farmers...

  3. Process for depositing I-125 onto a substrate used to manufacture I-125 sources

    DOEpatents

    McGovern, James J.; Olynyk, Joseph M.

    1988-01-01

    The invention relates to a process for depositing I-125 on a substrate which comprises contacting a predetermined surface area of substrate with Xe-125 gas, whereby the Xe-125 decays to I-125 and the I-125 in turn deposits as a solid on the surface of the substrate, the contact being for a time sufficient to deposit at least about 1 microcurie of I-125. I-125 is thereby deposited in a relatively uniform amount over the surface area of the substrate. The substrate is then assayed to determine how much I-125 has been deposited. The substrate is then divided into pieces of measured surface area, each piece therefore containing a measured amount of deposited I-125, and each piece can then be used in the manufacture of an I-125 source.

  4. Flood-Frequency Estimates for Streams on Kaua`i, O`ahu, Moloka`i, Maui, and Hawai`i, State of Hawai`i

    USGS Publications Warehouse

    Oki, Delwyn S.; Rosa, Sarah N.; Yeung, Chiu W.

    2010-01-01

    This study provides an updated analysis of the magnitude and frequency of peak stream discharges in Hawai`i. Annual peak-discharge data collected by the U.S. Geological Survey during and before water year 2008 (ending September 30, 2008) at stream-gaging stations were analyzed. The existing generalized-skew value for the State of Hawai`i was retained, although three methods were used to evaluate whether an update was needed. Regional regression equations were developed for peak discharges with 2-, 5-, 10-, 25-, 50-, 100-, and 500-year recurrence intervals for unregulated streams (those for which peak discharges are not affected to a large extent by upstream reservoirs, dams, diversions, or other structures) in areas with less than 20 percent combined medium- and high-intensity development on Kaua`i, O`ahu, Moloka`i, Maui, and Hawai`i. The generalized-least-squares (GLS) regression equations relate peak stream discharge to quantified basin characteristics (for example, drainage-basin area and mean annual rainfall) that were determined using geographic information system (GIS) methods. Each of the islands of Kaua`i,O`ahu, Moloka`i, Maui, and Hawai`i was divided into two regions, generally corresponding to a wet region and a dry region. Unique peak-discharge regression equations were developed for each region. The regression equations developed for this study have standard errors of prediction ranging from 16 to 620 percent. Standard errors of prediction are greatest for regression equations developed for leeward Moloka`i and southern Hawai`i. In general, estimated 100-year peak discharges from this study are lower than those from previous studies, which may reflect the longer periods of record used in this study. Each regression equation is valid within the range of values of the explanatory variables used to develop the equation. The regression equations were developed using peak-discharge data from streams that are mainly unregulated, and they should not be used to

  5. Dynamics of the F(-) + CH3I → HF + CH2I(-) Proton Transfer Reaction.

    PubMed

    Zhang, Jiaxu; Xie, Jing; Hase, William L

    2015-12-17

    Direct chemical dynamics simulations, at collision energies Erel of 0.32 and 1.53 eV, were performed to obtain an atomistic understanding of the F(-) + CH3I reaction dynamics. There is only the F(-) + CH3I → CH3F + I(-) bimolecular nucleophilic substitution SN2 product channel at 0.32 eV. Increasing Erel to 1.53 eV opens the endothermic F(-) + CH3I → HF + CH2I(-) proton transfer reaction, which is less competitive than the SN2 reaction. The simulations reveal proton transfer occurs by two direct atomic-level mechanisms, rebound and stripping, and indirect mechanisms, involving formation of the F(-)···HCH2I complex and the roundabout. For the indirect trajectories all of the CH2I(-) is formed with zero-point energy (ZPE), while for the direct trajectories 50% form CH2I(-) without ZPE. Without a ZPE constraint for CH2I(-), the reaction cross sections for the rebound, stripping, and indirect mechanisms are 0.2 ± 0.1, 1.2 ± 0.4, and 0.7 ± 0.2 Å(2), respectively. Discarding trajectories that do not form CH2I(-) with ZPE reduces the rebound and stripping cross sections to 0.1 ± 0.1 and 0.7 ± 0.5 Å(2). The HF product is formed rotationally and vibrationally unexcited. The average value of J is 2.6 and with histogram binning n = 0. CH2I(-) is formed rotationally excited. The partitioning between CH2I(-) vibration and HF + CH2I(-) relative translation energy depends on the treatment of CH2I(-) ZPE. Without a CH2I(-) ZPE constraint the energy partitioning is primarily to relative translation with little CH2I(-) vibration. With a ZPE constraint, energy partitioning to CH2I(-) rotation, CH2I(-) vibration, and relative translation are statistically the same. The overall F(-) + CH3I rate constant at Erel of both 0.32 and 1.53 eV is in good agreement with experiment and negligibly affected by the treatment of CH2I(-) ZPE, since the SN2 reaction is the major contributor to the total reaction rate constant. The potential energy surface and reaction dynamics for F

  6. Identification of the meiotic toolkit in diatoms and exploration of meiosis-specific <i>SPO11i> and <i>RAD51i> homologs in the sexual species <i>Pseudo-nitzschia multistriatai> and <i>Seminavis robustai>

    SciTech Connect

    Patil, Shrikant; Moeys, Sara; von Dassow, Peter; Huysman, Marie J. J.; Mapleson, Daniel; De Veylder, Lieven; Sanges, Remo; Vyverman, Wim; Montresor, Marina; Ferrante, Maria Immacolata

    2015-11-14

    Sexual reproduction is an obligate phase in the life cycle of most eukaryotes. Meiosis varies among organisms, which is reflected by the variability of the gene set associated to the process. Diatoms are unicellular organisms that belong to the stramenopile clade and have unique life cycles that can include a sexual phase. The exploration of five diatom genomes and one diatom transcriptome led to the identification of 42 genes potentially involved in meiosis. While these include the majority of known meiosis-related genes, several meiosis-specific genes, including <i>DMC1i>, could not be identified. Furthermore, phylogenetic analyses supported gene identification and revealed ancestral loss and recent expansion in the <i>RAD51i> family in diatoms. The two sexual species Pseudo-nitzschia multistriata and Seminavis robusta were used to explore the expression of meiosis-related genes: <i>RAD21, SPO11-2, RAD51-A, RAD51-Bi> and <i>RAD51-Ci> were upregulated during meiosis, whereas other paralogs in these families showed no differential expression patterns, suggesting that they may play a role during vegetative divisions. An almost identical toolkit is shared among <i>Pseudo-nitzschia multiseriesi> and <i>Fragilariopsis cylindrusi>, as well as two species for which sex has not been observed, <i>Phaeodactylum tricornutumi> and <i>Thalassiosira pseudonanai>, suggesting that these two may retain a facultative sexual phase. Lastly, our results reveal the conserved meiotic toolkit in six diatom species and indicate that Stramenopiles share major modifications of canonical meiosis processes ancestral to eukaryotes, with important divergences in each Kingdom.

  7. 25 CFR 247.8 - What am I responsible for if I use the facilities?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What am I responsible for if I use the facilities? 247.8 Section 247.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.8 What am I responsible for if I use the facilities? You are responsible for: (a) Campsites,...

  8. Heteroclite electrochemical stability of an I based Li7P2S8I superionic conductor

    DOE PAGESBeta

    Rangasamy, Ezhiylmurugan; Liu, Zengcai; Gobet, Mallory; Pilar, Kartik; Sahu, Gayatri; Greenbaum, Steve; Liang, Chengdu

    2015-01-01

    Stability from Instability: A Li7P2S8I solid state Li-ion conductor derived from -Li3PS4 and LiI demonstrates exceptional electrochemical stability. The oxidation instability of I is subverted nullified via its incorporation into the coordinated structure. The inclusion of I also creates stability with metallic Li anode while simultaneously improving the interfacial kinetics. Low temperature membrane processability enables facile fabrication of dense membranes, making it suitable for industrial adoption.

  9. I'm a Map, I'm a Green Tree

    ERIC Educational Resources Information Center

    Anderson, Daniel

    2010-01-01

    I'm talking about the ways we represent ourselves and our world. I've put some thoughts on the topic together here--a gathering that enacts new media creating and takes up conceptual layers like metaphors, models, and composing. The primary sources are videos from the Get a Mac campaign, aka I'm a Mac; I'm a PC ads. Posthuman concepts blending…

  10. Verification of Ares I Liftoff Acoustic Environments via the Ares I Scale Model Acoustic Test

    NASA Technical Reports Server (NTRS)

    Counter, Douglas; Houston, Janice

    2012-01-01

    The Ares I Scale Model Acoustic Test (ASMAT) program was implemented to verify the predicted Ares I liftoff acoustic environments and to determine the acoustic reduction gained by using an above deck water sound suppression system. The test article included a 5% scale Ares I vehicle model and Mobile Launcher with tower. Acoustic and pressure data were measured by over 200 instruments. The ASMAT results are compared to Ares I-X flight data.

  11. Extraction of (129)I and (127)I via combustion from organic rich samples using (125)I as a quantitative tracer.

    PubMed

    Herod, Matthew N; Cornett, R Jack; Clark, Ian D; Kieser, W E; Jean, Gilles St

    2014-12-01

    Iodine-129 ((129)I) is a biophilic, naturally occurring radioisotope (half-life: 1.57 × 10(7) years) that has been released in large quantities by nuclear fuel reprocessing. This iodine has cycled throughout the globe and chiefly the northern hemisphere and can be found in a wide variety of environmental materials, particularly organic rich soil and organic matter. Extracting iodine reliably from solid samples has been done by a variety of methods, however, pyrohydrolysis has been the most widely used. There is a wide variation between existing pyrohydrolysis techniques and this raises questions about the quantitative recovery of iodine from method to method. In order to quantify iodine recovery from pyrohydrolysis we have spiked samples with an iodine-125 radiotracer prior to combustion and trapping in an alkaline solution. Inorganic (125)I tracer was used as well as humic acid labeled with (125)I to simulate the behavior of (129)I and (127)I in complex organic substances and extract iodine regardless of how it is partitioned. Using these tracers we explored the effect on recovery of (125)I under a variety of combustion parameters. These include carrier gas flow rate and iodine volatilization temperature. We observed that the best recoveries of (125)I were at flow rates between 400 and 800 mL/min and most (125)I recoveries were above 85%. The experiment to determine the temperature at which iodine volatilizes from the sample showed two distinct trends for the release of iodine. One trend showed that most iodine is released at approximately 525 °C, while the other trend showed that the samples needed to reach 800 °C and remain there for at least an hour. These findings illustrate the usefulness and importance of using a quantitative recovery tracer for every iodine extraction. We then combusted and precipitated several Atlantic Ocean seaweed and standard reference materials for AMS analysis as AgI. The (129)I concentration of the seaweed ranged between 4

  12. 21 CFR 822.27 - If I go out of business, what must I do?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false If I go out of business, what must I do? 822.27 Section 822.27 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Responsibilities of Manufacturers § 822.27 If I go out...

  13. 49 CFR 375.303 - If I sell liability insurance coverage, what must I do?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false If I sell liability insurance coverage, what must... Options Provided § 375.303 If I sell liability insurance coverage, what must I do? (a) You, your employee... damage in excess of the specified carrier liability. (c) If you sell, offer to sell, or procure...

  14. 49 CFR 375.303 - If I sell liability insurance coverage, what must I do?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false If I sell liability insurance coverage, what must... Options Provided § 375.303 If I sell liability insurance coverage, what must I do? (a) You, your employee... damage in excess of the specified carrier liability. (c) If you sell, offer to sell, or procure...

  15. 30 CFR 203.75 - What risk do I run if I request a redetermination?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What risk do I run if I request a redetermination? 203.75 Section 203.75 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... run if I request a redetermination? If you request a redetermination after we have granted you...

  16. The shear fracture toughness, <i>KIIc>, of graphite

    SciTech Connect

    Burchell, Timothy D.; Erdman, III, Donald L.

    2015-11-05

    In this study, the critical shear stress intensity factor, <i>KIIc>, here-in referred to as the shear fracture toughness, <i>KIIc> (MPa m), of two grades of graphite are reported. The range of specimen volumes was selected to elucidate any specimen size effect, but smaller volume specimen tests were largely unsuccessful, shear failure did not occur between the notches as expected. This was probably due to the specimen geometry causing the shear fracture stress to exceed the compressive failure stress. In subsequent testing the specimen geometry was altered to reduce the compressive footprint and the notches (slits) made deeper to reduce the specimen's ligament length. Additionally, we added the collection of Acoustic Emission (AE) during testing to assist with the identification of the shear fracture load. The means of <i>KIIc> from large specimens for PCEA and NBG-18 are 2.26 MPa m with an SD of 0.37 MPa m and 2.20 MPa m with an SD of 0.53 MPa m, respectively. The value of <i>KIIc> for both graphite grades was similar, although the scatter was large. In this work we found the ratio of <i>KIIci>/KIc> ≈ 1.6. .

  17. An approach for measuring the 129I/127I ratio in fish samples

    NASA Astrophysics Data System (ADS)

    Kusuno, Haruka; Matsuzaki, Hiroyuki; Nagata, Toshi; Miyairi, Yosuke; Yokoyama, Yusuke; Ohkouchi, Naohiko

    2015-10-01

    The 129I/127I ratio in marine fish samples was measured employing accelerator mass spectrometry. The measurement was successful because of the low experimental background of 129I. Pyrohydrolysis was applied to extract iodine from fish samples. The experimental background of pyrohydrolysis was checked carefully and evaluated as 104-105 atoms 129I/combustion. The methodology employed in the present study thus required only 0.05-0.2 g of dried fish samples. The methodology was then applied to obtain the 129I/127I ratio of marine fish samples collected from the Western Pacific Ocean as (0.63-1.2) × 10-10. These values were similar to the ratio for the surface seawater collected at the same station, 0.4 × 10-10. The 129I/127I ratio of IAEA-414, which was a mix of fish from the Irish Sea and the North Sea, was also measured and determined as 1.82 × 10-7. Consequently, fish from the Western Pacific Ocean and the North Sea were distinguished by their 129I/127I ratios. The 129I/127I ratio is thus a direct indicator of the area of habitat of fish.

  18. 30 CFR 250.1753 - After I decommission a pipeline, what information must I submit?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false After I decommission a pipeline, what... SHELF Decommissioning Activities Pipeline Decommissioning § 250.1753 After I decommission a pipeline, what information must I submit? Within 30 days after you decommission a pipeline, you must submit...

  19. 30 CFR 250.1753 - After I decommission a pipeline, what information must I submit?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false After I decommission a pipeline, what... SHELF Decommissioning Activities Pipeline Decommissioning § 250.1753 After I decommission a pipeline, what information must I submit? Within 30 days after you decommission a pipeline, you must submit...

  20. 30 CFR 250.1753 - After I decommission a pipeline, what information must I submit?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false After I decommission a pipeline, what... SHELF Decommissioning Activities Pipeline Decommissioning § 250.1753 After I decommission a pipeline, what information must I submit? Within 30 days after you decommission a pipeline, you must submit...

  1. 49 CFR 512.19 - What can I do if I disagree with the determination?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false What can I do if I disagree with the determination? 512.19 Section 512.19 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONFIDENTIAL BUSINESS INFORMATION Agency Determination § 512.19 What can I...

  2. 21 CFR 822.27 - If I go out of business, what must I do?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false If I go out of business, what must I do? 822.27 Section 822.27 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Responsibilities of Manufacturers § 822.27 If I go out...

  3. 30 CFR 250.1753 - After I decommission a pipeline, what information must I submit?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false After I decommission a pipeline, what... OUTER CONTINENTAL SHELF Decommissioning Activities Pipeline Decommissioning § 250.1753 After I decommission a pipeline, what information must I submit? Within 30 days after you decommission a pipeline,...

  4. 30 CFR 250.1753 - After I decommission a pipeline, what information must I submit?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false After I decommission a pipeline, what... Decommissioning Activities Pipeline Decommissioning § 250.1753 After I decommission a pipeline, what information must I submit? Within 30 days after you decommission a pipeline, you must submit a written report...

  5. A network biology approach to denitrification in <i>Pseudomonas aeruginosai>

    SciTech Connect

    Arat, Seda; Bullerjahn, George S.; Laubenbacher, Reinhard

    2015-02-23

    <i>Pseudomonas aeruginosai> is a metabolically flexible member of the Gammaproteobacteria. Under anaerobic conditions and the presence of nitrate, <i>P. aeruginosai> can perform (complete) denitrification, a respiratory process of dissimilatory nitrate reduction to nitrogen gas via nitrite (NO₂), nitric oxide (NO) and nitrous oxide (N₂O). This study focuses on understanding the influence of environmental conditions on bacterial denitrification performance, using a mathematical model of a metabolic network in <i>P. aeruginosai>. To our knowledge, this is the <i>first> mathematical model of denitrification for this bacterium. Analysis of the long-term behavior of the network under changing concentration levels of oxygen (O₂), nitrate (NO₃), and phosphate (PO₄) suggests that PO₄ concentration strongly affects denitrification performance. The model provides three predictions on denitrification activity of <i>P. aeruginosai> under various environmental conditions, and these predictions are either experimentally validated or supported by pertinent biological literature. One motivation for this study is to capture the effect of PO₄ on a denitrification metabolic network of <i>P. aeruginosai> in order to shed light on mechanisms for greenhouse gas N₂O accumulation during seasonal oxygen depletion in aquatic environments such as Lake Erie (Laurentian Great Lakes, USA). Simulating the microbial production of greenhouse gases in anaerobic aquatic systems such as Lake Erie allows a deeper understanding of the contributing environmental effects that will inform studies on, and remediation strategies for, other hypoxic sites worldwide.

  6. 30 CFR 1204.212 - What if I took relief for which I was ineligible?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false What if I took relief for which I was ineligible? 1204.212 Section 1204.212 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR Natural Resources Revenue ALTERNATIVES FOR MARGINAL PROPERTIES Accounting and Auditing Relief § 1204.212 What if I...

  7. Detailed kinetic modeling study of <i>n>-pentanol oxidation

    SciTech Connect

    Heufer, K. Alexander; Sarathy, S. Mani; Curran, Henry J.; Davis, Alexander C.; Westbrook, Charles K.; Pitz, William J.

    2012-09-28

    To help overcome the world’s dependence upon fossil fuels, suitable biofuels are promising alternatives that can be used in the transportation sector. Recent research on internal combustion engines shows that short alcoholic fuels (e.g., ethanol or <i>n>-butanol) have reduced pollutant emissions and increased knock resistance compared to fossil fuels. Although higher molecular weight alcohols (e.g., <i>n>-pentanol and <i>n>-hexanol) exhibit higher reactivity that lowers their knock resistance, they are suitable for diesel engines or advanced engine concepts, such as homogeneous charge compression ignition (HCCI), where higher reactivity at lower temperatures is necessary for engine operation. The present study presents a detailed kinetic model for <i>n>-pentanol based on modeling rules previously presented for <i>n>-butanol. This approach was initially validated using quantum chemistry calculations to verify the most stable <i>n>-pentanol conformation and to obtain C–H and C–C bond dissociation energies. In addition, the proposed model has been validated against ignition delay time data, speciation data from a jet-stirred reactor, and laminar flame velocity measurements. Overall, the model shows good agreement with the experiments and permits a detailed discussion of the differences between alcohols and alkanes.

  8. 43 CFR 3505.30 - May I amend or change my application after I file it?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false May I amend or change my application after I file it? 3505.30 Section 3505.30 Public Lands: Interior Regulations Relating to Public Lands... amend or change my application after I file it? Yes. However, if your amendment adds lands, we...

  9. 43 CFR 3505.31 - May I withdraw my application after I file it?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false May I withdraw my application after I file it? 3505.31 Section 3505.31 Public Lands: Interior Regulations Relating to Public Lands (Continued... withdraw my application after I file it? Yes. Just send us a written request. If you withdraw...

  10. 43 CFR 3505.31 - May I withdraw my application after I file it?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false May I withdraw my application after I file it? 3505.31 Section 3505.31 Public Lands: Interior Regulations Relating to Public Lands (Continued... withdraw my application after I file it? Yes. Just send us a written request. If you withdraw...

  11. 43 CFR 3505.31 - May I withdraw my application after I file it?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false May I withdraw my application after I file it? 3505.31 Section 3505.31 Public Lands: Interior Regulations Relating to Public Lands (Continued... withdraw my application after I file it? Yes. Just send us a written request. If you withdraw...

  12. 43 CFR 3505.30 - May I amend or change my application after I file it?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false May I amend or change my application after I file it? 3505.30 Section 3505.30 Public Lands: Interior Regulations Relating to Public Lands... amend or change my application after I file it? Yes. However, if your amendment adds lands, we...

  13. 43 CFR 3505.31 - May I withdraw my application after I file it?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false May I withdraw my application after I file it? 3505.31 Section 3505.31 Public Lands: Interior Regulations Relating to Public Lands (Continued... withdraw my application after I file it? Yes. Just send us a written request. If you withdraw...

  14. How Do I Know What I Can Do? Anticipating Expectancy of Success Regarding Novel Academic Tasks

    ERIC Educational Resources Information Center

    Gorges, Julia; Göke, Thomas

    2015-01-01

    Background: After graduation from secondary school, academic tasks (i.e., learning contents) are no longer structured in terms of school subjects (i.e., English, mathematics). Therefore, learners lack past performance and mastery experience to inform their expectancy of success (i.e., ability beliefs) regarding novel tasks. Aims: In this paper, we…

  15. Biodistribution and dosimetry of free 211At, 125I- and 131I- in rats.

    PubMed

    Spetz, Johan; Rudqvist, Nils; Forssell-Aronsson, Eva

    2013-11-01

    131I is widely used for therapy in the clinic and 125I and 131I, and increasingly 211At, are often used in experimental studies. It is important to know the biodistribution and dosimetry for these radionuclides to determine potential risk organs when using radiopharmaceuticals containing these radionuclides. The purpose of this study was to investigate the biodistribution of 125I-, 131I-, and free 211At in rats and to determine absorbed doses to various organs and tissues. Male Sprague Dawley rats were injected simultaneously with 0.1-0.3 MBq 125I- and 0.1-0.3 MBq 131I-, or 0.05-0.2 MBq 211At and sacrificed 1 hour to 7 days after injection. The activities and activity concentrations in organs and tissues were determined and mean absorbed doses were calculated. The biodistribution of 125I- was similar to that of 131I- but the biodistribution of free 211At was different compared to 125I- and 131I-. The activity concentration of radioiodine was higher compared with 211At in the thyroid and lower in all extrathyroidal tissues. The mean absorbed dose per unit injected activity was highest to the thyroid. 131I gave the highest absorbed dose to the thyroid, and 211At gave the highest absorbed dose to all other tissues studied. PMID:23789969

  16. 30 CFR 280.11 - What must I do before I may conduct scientific research?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... I may conduct scientific research? You may conduct G&G scientific research activities related to... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What must I do before I may conduct scientific research? 280.11 Section 280.11 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION,...

  17. Invited perspective: Why I am an optimist

    NASA Astrophysics Data System (ADS)

    Burges, Stephen J.

    2011-03-01

    I address a range of topics that provide the sociopolitical-technological setting for my professional life. I discuss some influential features of post-World War II world geopolitics, landmark technological developments of that era, and the resulting follow-up technologies that have made it possible to approach various problems in hydrology and water resources. I next address societal needs that have driven developments in hydrology and water resources engineering and follow with a discussion of the modern foundations of our science and what I think are the principal issues in hydrology. I pose three community challenges that when accomplished should advance hydrologic science: data network needs for improving the water budgets at all scales, characterizing subsurface water flow paths, and the information archiving and mining needs from instruments that will generate substantially richer data detail than have been used for most hydrologic work to the present. I then discuss several hydrologic and water resource risk-based decision issues that matter to society to illustrate how such risks have been addressed successfully in the past. I conclude with a long-term community "grand challenge," the coupled modeling of the ocean-atmosphere-landform hydrologic cycle for the purpose of long-lead time hydrologic prediction.

  18. Extinct I-129 in C3 chondrites

    NASA Technical Reports Server (NTRS)

    Crabb, J.; Lewis, R. S.; Anders, E.

    1982-01-01

    Eight C3 chondrites were examined by the I-129 to Xe-129 dating method to determine whether their initial I-129/I-127 ratios, or R(0), correlate with any other properties. The R(0)'s range from 1.60 x 10 to the -4th to 1.09 x 10 to the -4th, corresponding to I to Xe ages from 2.0 Myr before to 6.7 Myr after the Murchison magnetite. Three C30's have essentially indistinguishable R(0)'s, while a fourth is undatable. Four C3V's show a distinct spread, ranging from 1.60 + or 0.07 x 10 to the -4th to 1.09 + or - 0.10 x 10 to the -4th. These R(0)'s correlate inversely with four other properties: I, Br, and Cd content, olivine composition, both percent mean deviation, and proportion of iron-poor olivine grains. The simplest model that accounts for the correlations with R(0) involves mixing of two iodine components in the solar nebula, associated with gas and grains, respectively. The second, of lower I-129/I-127 ratio, predominated at later times and thus became enriched in late-formed meteorites.

  19. Re-evaluating DSM-I.

    PubMed

    Cooper, R; Blashfield, R K

    2016-02-01

    The DSM-I is currently viewed as a psychoanalytic classification, and therefore unimportant. There are four reasons to challenge the belief that DSM-I was a psychoanalytic system. First, psychoanalysts were a minority on the committee that created DSM-I. Second, psychoanalysts of the time did not use DSM-I. Third, DSM-I was as infused with Kraepelinian concepts as it was with psychoanalytic concepts. Fourth, contemporary writers who commented on DSM-I did not perceive it as psychoanalytic. The first edition of the DSM arose from a blending of concepts from the Statistical Manual for the Use of Hospitals of Mental Diseases, the military psychiatric classifications developed during World War II, and the International Classification of Diseases (6th edition). As a consensual, clinically oriented classification, DSM-I was popular, leading to 20 printings and international recognition. From the perspective inherent in this paper, the continuities between classifications from the first half of the 20th century and the systems developed in the second half (e.g. DSM-III to DSM-5) become more visible. PMID:26470724

  20. Chemical destruction of CH3I, C2H5I, 1-C3H7I, and 2-C3H7I in saltwater

    NASA Astrophysics Data System (ADS)

    Jones, Charlotte E.; Carpenter, Lucy J.

    2007-07-01

    Destruction of volatile iodocarbons in the oceans can potentially play an important role in determining the predominant chemical forms of iodine emitted to the atmosphere. Here we report chlorination and hydrolysis removal rates for CH3I, C2H5I, 1-C3H7I, and 2-C3H7I relevant to oceanic conditions. We have used these rates to calculate oceanic lifetimes for each iodocarbon with respect to total chemical destruction, as a function of seawater temperature. The resulting lifetimes are compared to typical iodocarbon oceanic residence times with respect to volatilization to the MBL. The rate of destruction of 2-C3H7I is much more rapid than chemical removal of the primary alkyl iodides, potentially explaining previous observations of lower 2-C3H7I concentrations in seawater compared to 1-C3H7I. Finally, in light of these results, we briefly discuss the potential impact of rising global seawater temperatures on oceanic iodocarbon concentrations.

  1. Illustration of Ares I During Launch

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The NASA developed Ares rockets, named for the Greek god associated with Mars, will return humans to the moon and later take them to Mars and other destinations. In this early illustration, the Ares I is illustrated during lift off. Ares I is an inline, two-stage rocket configuration topped by the Orion crew vehicle and its launch abort system. With a primary mission of carrying four to six member crews to Earth orbit, Ares I may also use its 25-ton payload capacity to deliver resources and supplies to the International Space Station (ISS), or to 'park' payloads in orbit for retrieval by other spacecraft bound for the moon or other destinations. Ares I uses a single five-segment solid rocket booster, a derivative of the space shuttle solid rocket booster, for the first stage. A liquid oxygen/liquid hydrogen J-2X engine, derived from the J-2 engine used on the second stage of the Apollo vehicle, will power the Ares I second stage. Ares I can lift more than 55,000 pounds to low Earth orbit. The Ares I is subject to configuration changes before it is actually launched. This illustration reflects the latest configuration as of September 2006.

  2. Tumor suppressor activity of RIG-I

    PubMed Central

    Li, Xian-Yang; Guo, He-Zhou; Zhu, Jiang

    2014-01-01

    Retinoic acid inducible gene-I (RIG-I), named for the observation that its mRNA expression is highly upregulated in the progression of all-trans retinoic acid (ATRA)-induced maturation of acute promyelocytic leukemia (APL) cells, has been well documented as a pivotal virus-associated molecular pattern recognition receptor (PRR) responsible for triggering innate immunity. Upon recognizing viral RNA ligands, RIG-I experiences a series of programmed conformational changes and modifications that unleash its activity through the formation of complexes with various binding partners. Such partners include the mitochondria membrane-anchored protein IPS-1 (also named MAVS/VISA/Cardif) that activates both the IRF3/7 and NF-κB pathways. These partnerships and resulting pathway activations underlie the synthesis of type I interferon and other inflammatory factors. Recent studies have demonstrated that RIG-I is also involved in the regulation of basic cellular processes outside of innate immunity against viral infections, such as hematopoietic proliferation and differentiation, maintenance of leukemic stemness, and tumorigenesis of hepatocellular carcinoma. In this review, we will highlight recent studies leading up to the recognition that RIG-I performs an essential function as a tumor suppressor and try to reconcile this activity of RIG-I with its well-known role in protecting cells against viral infection. PMID:27308362

  3. Carbon Dioxide, Hydrographic, and Chemical Data Obtained During the Nine R/V Korr Cruises Comprising the Indian Ocean CO2Survey (WOCE Sections I8SI9S, I9N, I8NI5E, I3, I5WI4, I7N, I1, I10, and I2; December 1, 1994-January 19, 1996)

    SciTech Connect

    Kozyr, A.V.

    2003-09-15

    This document describes the procedures and methods used to measure total carbon dioxide (TCO{sub 2}) and total alkalinity (TALK) at hydrographic stations taken during the R/V Knorr Indian Ocean cruises (Sections I8SI9S, I9N, I8NI5E, I3, I5WI4, I7N, I1, I10, and I2) in 1994-1996. The measurements were conducted as part of the World Ocean Circulation Experiment (WOCE). The expedition began in Fremantle, Australia, on December 1, 1994, and ended in Mombasa, Kenya, on January 22, 1996. During the nine cruises, 12 WOCE sections were occupied. Total carbon dioxide was extracted from water samples and measured using single-operator multiparameter metabolic analyzers (SOMMAs) coupled to coulometers. The overall precision and accuracy of the analyses was {+-} 1.20 {micro}mol/kg. The second carbonate system parameter, TALK, was determined by potentiometric titration. The precision of the measurements determined from 962 analyses of certified reference material was {+-} 4.2 {micro}mol/kg (REFERENCE). This work was supported by grants from the National Science Foundation, the U. S. Department of Energy, and the National Oceanographic and Atmospheric Administration. The R/V Knorr Indian Ocean data set is available as a numeric data package (NDP) from the Carbon Dioxide Information Analysis Center (CDIAC). The NDP consists of 18 oceanographic data files, two FORTRAN 77 data retrieval routine files, a readme file, and this printed documentation, which describes the contents and format of all files as well as the procedures and methods used to obtain the data. Instructions for accessing the data are provided.

  4. Rational engineering of <i>Geobacter sulfurreducensi> electron transfer components: A foundation for building improved <i>Geobacter>-based bioelectrochemical technologies

    SciTech Connect

    Dantas, Joana M.; Morgado, Leonor; Aklujkar, Muktak; Bruix, Marta; Londer, Yuri Y.; Schiffer, Marianne; Pokkuluri, P. Raj; Salgueiro, Carlos A.

    2015-07-30

    Multiheme cytochromes have been implicated in <i>Geobacter sulfurreducensi> extracellular electron transfer (EET). These proteins are potential targets to improve EET and enhance bioremediation and electrical current production by <i>G. sulfurreducensi>. However, the functional characterization of multiheme cytochromes is particularly complex due to the co-existence of several microstates in solution, connecting the fully reduced and fully oxidized states. Throughout the last decade, new strategies have been developed to characterize multiheme redox proteins functionally and structurally. These strategies were used to reveal the functional mechanism of <i>G. sulfurreducensi> multiheme cytochromes and also to identify key residues in these proteins for EET. In previous studies, we set the foundations for enhancement of the EET abilities of <i>G. sulfurreducensi> by characterizing a family of five triheme cytochromes (PpcA-E). These periplasmic cytochromes are implicated in electron transfer between the oxidative reactions of metabolism in the cytoplasm and the reduction of extracellular terminal electron acceptors at the cell's outer surface. The results obtained suggested that PpcA can couple e-/H+ transfer, a property that might contribute to the proton electrochemical gradient across the cytoplasmic membrane for metabolic energy production. The structural and functional properties of PpcA were characterized in detail and used for rational design of a family of 23 single site PpcA mutants. In this review, we summarize the functional characterization of the native and mutant proteins. Mutants that retain the mechanistic features of PpcA and adopt preferential e-/H+ transfer pathways at lower reduction potential values compared to the wild-type protein were selected for in vivo studies as the best candidates to increase the electron transfer rate of <i>G. sulfurreducensi>. For the first time <i>G. sulfurreducensi

  5. Type I interferonopathies in pediatric rheumatology.

    PubMed

    Volpi, Stefano; Picco, Paolo; Caorsi, Roberta; Candotti, Fabio; Gattorno, Marco

    2016-01-01

    Defective regulation of type I interferon response is associated with severe inflammatory phenotypes and autoimmunity. Type I interferonopathies are a clinically heterogenic group of Mendelian diseases with a constitutive activation of this pathway that might present as atypical, severe, early onset rheumatic diseases. Skin vasculopathy with chilblains and livedo reticularis, interstitial lung disease, and panniculitis are common. Recent studies have implicated abnormal responses to nucleic acid stimuli or defective regulation of downstream effector molecules in disease pathogenesis. As observed for IL1-β and autoinflammatory diseases, knowledge of the defects responsible for type I interferonopathies will likely promote the development of targeted therapy. PMID:27260006

  6. I&C Modeling in SPAR Models

    SciTech Connect

    John A. Schroeder

    2012-06-01

    The Standardized Plant Analysis Risk (SPAR) models for the U.S. commercial nuclear power plants currently have very limited instrumentation and control (I&C) modeling [1]. Most of the I&C components in the operating plant SPAR models are related to the reactor protection system. This was identified as a finding during the industry peer review of SPAR models. While the Emergency Safeguard Features (ESF) actuation and control system was incorporated into the Peach Bottom Unit 2 SPAR model in a recent effort [2], various approaches to expend resources for detailed I&C modeling in other SPAR models are investigated.

  7. Yakov Abramovich as i Remember him

    NASA Astrophysics Data System (ADS)

    Nyíri, Julia

    2013-06-01

    I first heard of Yakov Abramovich when (being a student of the Leningrad State University) I read his papers written with Pomeranchuk and Landau [1]. Later, in my last year at the university, thinking about a possible future working place, I met G. Domokos who at that time was a researcher in Dubna. He gave me the advice to go to Dubna for a while and look for the possibility to work with Professor Smorodinsky who was the broadest-minded physicist he had ever met...

  8. Efficient algorithms for Hirshfeld-I charges

    SciTech Connect

    Finzel, Kati; Martín Pendás, Ángel; Francisco, Evelio

    2015-08-28

    A new viewpoint on iterative Hirshfeld charges is presented, whereby the atomic populations obtained from such a scheme are interpreted as such populations which reproduce themselves. This viewpoint yields a self-consistent requirement for the Hirshfeld-I populations rather than being understood as the result of an iterative procedure. Based on this self-consistent requirement, much faster algorithms for Hirshfeld-I charges have been developed. In addition, new atomic reference densities for the Hirshfeld-I procedure are presented. The proposed reference densities are N-representable, display proper atomic shell structure and can be computed for any charged species.

  9. Emission properties and Cu(i)-Cu(i) interaction in 2-coordinate dicopper(i)-bis(N-heterocyclic)carbene complexes.

    PubMed

    Nishikawa, Michihiro; Sano, Taichi; Washimi, Masaya; Takao, Koichiro; Tsubomura, Taro

    2016-07-26

    The synthesis, characterization, and emission properties of 2-coordinate dicopper(i) complexes bearing two trimethylene-bridged bis-NHC ligands, [Cu2(L3Me)2](PF6)2 (1), [Cu2(L3Et)2](PF6)2 (2), [Cu2(L3Bu)2](PF6)2 (3), [Cu2(L3MeOPh)2](PF6)2 (4) and [Cu2(L3Mes)2](PF6)2 (5), where L3R denotes trimethylene-bridged bis(N-heterocyclic)carbene (NHC) ligand substituted by two R groups at the nitrogen atoms of NHC, have been investigated. The quantum yield, Φ, and the lifetime, τ, of the emission of 2, are 0.21 and 25 μs, respectively in methanol, which is a well-known solvent for quenching the luminescence of many copper(i) complexes. The 8-shaped geometry of the dicopper(i) complexes brings a considerable copper(i)-copper(i) interaction which affects the luminescent properties. Additionally, we find that methoxyphenyl and mesityl groups substituted at the nitrogen atom of the NHC moiety drastically stabilize the bis(NHC) copper(i) complexes even in air-saturated acetone-d6. PMID:27399152

  10. Effect of ethane-I-hydroxy-I, I-diphosphonate on arterial calcinosis induced by hypervitaminosis D: a morphologic investigation.

    PubMed Central

    Kingma, J. G.; Roy, P. E.

    1990-01-01

    The present study was undertaken to examine changes in vascular ultrastructure of rats subjected to hypervitaminosis D with or without treatment with ethane-I-hydroxy-I, I-diphosphonate (EHDP). Five groups of rats were studied. Untreated rats were given 0.9% NaCl i.p. Sham-treated rats were given vehicle (corn oil). Treated rats were given ergocalciferol (75,000 IU i.p.) dissolved in vehicle with or without EHDP (5 mM/100 g body-weight i.p.). Rats which had been given ergocalciferol without EHDP developed hypercalcemia and demonstrated significant arterial calcinosis. A similar degree of calcinosis was not observed in rats given ergocalciferol with EHDP. EHDP appeared to inhibit arterial calcinosis; however, it did not affect plasma calcium levels. This suggests that EHDP might delay calcium influx into the cell and thereby prevent calcium overload. Our findings support the suggestion that EHDP therapy can be an effective treatment for the inhibition of dystrophic arterial calcinosis. Images Fig. 2 Fig. 3 Fig. 4 PMID:2109995

  11. Chaos and localization in the wave functions of complex atoms Nd I, Pm I, and Sm I

    SciTech Connect

    Angom, Dilip; Kota, V.K.B.

    2005-04-01

    Wave functions of complex lanthanide atoms Nd I, Pm I, and Sm I, obtained via multiconfiguration Dirac-Fock method, are analyzed for density of states in terms of partial densities, strength functions [F{sub k}(E)], number of principal components [{xi}{sub 2}(E)], and occupancies ({sup E}) of single-particle orbits using embedded Gaussian orthogonal ensemble of one plus two-body random matrix ensembles [EGOE(1+2)]. It is seen that density of states are in general multi-modal, F{sub k}(E)'s exhibit variations as function of the basis states energy and {xi}{sub 2}(E)'s show structures arising from localized states. The sources of these departures from EGOE(1+2) are investigated by examining the partial densities, correlations between F{sub k}(E), {xi}{sub 2}(E), and {sup E} and also by studying the structure of the Hamiltonian matrices. These studies point out the operation of EGOE(1+2) but at the same time suggest that weak admixing between well separated configurations should be incorporated into EGOE(1+2) for more quantitative description of chaos and localization in Nd I, Pm I, and Sm I.

  12. Impact of high 131I-activities on quantitative 124I-PET

    NASA Astrophysics Data System (ADS)

    Braad, P. E. N.; Hansen, S. B.; Høilund-Carlsen, P. F.

    2015-07-01

    Peri-therapeutic 124 I-PET/CT is of interest as guidance for radioiodine therapy. Unfortunately, image quality is complicated by dead time effects and increased random coincidence rates from high 131 I-activities. A series of phantom experiments with clinically relevant 124 I/131 I-activities were performed on a clinical PET/CT-system. Noise equivalent count rate (NECR) curves and quantitation accuracy were determined from repeated scans performed over several weeks on a decaying NEMA NU-2 1994 cylinder phantom initially filled with 25 MBq 124 I and 1250 MBq 131 I. Six spherical inserts with diameters 10-37 mm were filled with 124 I (0.45 MBq ml-1 ) and 131 I (22 MBq ml-1 ) and placed inside the background of the NEMA/IEC torso phantom. Contrast recovery, background variability and the accuracy of scatter and attenuation corrections were assessed at sphere-to-background activity ratios of 20, 10 and 5. Results were compared to pure 124 I-acquisitions. The quality of 124 I-PET images in the presence of high 131 I-activities was good and image quantification unaffected except at very high count rates. Quantitation accuracy and contrast recovery were uninfluenced at 131 I-activities below 1000 MBq, whereas image noise was slightly increased. The NECR peaked at 550 MBq of 131 I, where it was 2.8 times lower than without 131 I in the phantom. Quantitative peri-therapeutic 124 I-PET is feasible.

  13. Ares I-X Flight Test Vehicle Similitude to the Ares I Crew Launch Vehicle

    NASA Technical Reports Server (NTRS)

    Huebner, Lawrence D.; Smith, R. Marshall; Campbell, John R., Jr.; Taylor, Terry L.

    2008-01-01

    The Ares I-X Flight Test Vehicle is the first in a series of flight test vehicles that will take the Ares I Crew Launch Vehicle design from development to operational capability. The test flight is scheduled for April 2009, relatively early in the Ares I design process so that data obtained from the flight can impact the design of Ares I before its Critical Design Review. Because of the short time frame (relative to new launch vehicle development) before the Ares I-X flight, decisions about the flight test vehicle design had to be made in order to complete analysis and testing in time to manufacture the Ares I-X vehicle hardware elements. This paper describes the similarities and differences between the Ares I-X Flight Test Vehicle and the Ares I Crew Launch Vehicle. Areas of comparison include the outer mold line geometry, aerosciences, trajectory, structural modes, flight control architecture, separation sequence, and relevant element differences. Most of the outer mold line differences present between Ares I and Ares I-X are minor and will not have a significant effect on overall vehicle performance. The most significant impacts are related to the geometric differences in Orion Crew Exploration Vehicle at the forward end of the stack. These physical differences will cause differences in the flow physics in these areas. Even with these differences, the Ares I-X flight test is poised to meet all five primary objectives and six secondary objectives. Knowledge of what the Ares I-X flight test will provide in similitude to Ares I as well as what the test will not provide is important in the continued execution of the Ares I-X mission leading to its flight and the continued design and development of Ares I.

  14. Interrogation of the <i>Burkholderia pseudomalleii> genome to address differential virulence among isolates

    SciTech Connect

    Challacombe, Jean F.; Stubben, Chris J.; Klimko, Christopher P.; Welkos, Susan L.; Kern, Steven J.; Bozue, Joel A.; Worsham, Patricia L.; Cote, Christopher K.; Wolfe, Daniel N.; Badger, Jonathan H.

    2014-12-23

    Infection by the Gram-negative pathogen <i>Burkholderia pseudomalleii> results in the disease melioidosis, acquired from the environment in parts of southeast Asia and northern Australia. Clinical symptoms of melioidosis range from acute (fever, pneumonia, septicemia, and localized infection) to chronic (abscesses in various organs and tissues, most commonly occurring in the lungs, liver, spleen, kidney, prostate and skeletal muscle), and persistent infections in humans are difficult to cure. Understanding the basic biology and genomics of <i>B. pseudomalleii> is imperative for the development of new vaccines and therapeutic interventions. This formidable task is becoming more tractable due to the increasing number of <i>B. pseudomalleii> genomes that are being sequenced and compared. Here, we compared three <i>B. pseudomalleii> genomes, from strains MSHR668, K96243 and 1106a, to identify features that might explain why MSHR668 is more virulent than K96243 and 1106a in a mouse model of <i>B. pseudomalleii> infection. Our analyses focused on metabolic, virulence and regulatory genes that were present in MSHR668 but absent from both K96243 and 1106a. We also noted features present in K96243 and 1106a but absent from MSHR668, and identified genomic differences that may contribute to variations in virulence noted among the three <i>B. pseudomalleii> isolates. While this work contributes to our understanding of <i>B. pseudomalleii> genomics, more detailed experiments are necessary to characterize the relevance of specific genomic features to <i>B. pseudomalleii> metabolism and virulence. Functional analyses of metabolic networks, virulence and regulation shows promise for examining the effects of <i>B. pseudomalleii> on host cell metabolism and will lay a foundation for future prediction of the virulence of emerging strains. Continued emphasis in this area will be critical for protection against melioidosis, as a better understanding of what

  15. 49 CFR Appendix - Figures to Subpart I of Part 572

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... conditions. Pt. 572, Subpt. I, Figs. Figures to Subpart I of Part 572 Pt. 572, Subpt. I, Fig. 40 EC01AU91.169 Pt. 572, Subpt. I, Fig. 41 EC01AU91.170 Pt. 572, Subpt. I, Fig. 42 EC01AU91.171 Pt. 572, Subpt. I, Fig. 43 EC01AU91.172...

  16. 49 CFR Appendix - Figures to Subpart I of Part 572

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... conditions. Pt. 572, Subpt. I, Figs. Figures to Subpart I of Part 572 Pt. 572, Subpt. I, Fig. 40 EC01AU91.169 Pt. 572, Subpt. I, Fig. 41 EC01AU91.170 Pt. 572, Subpt. I, Fig. 42 EC01AU91.171 Pt. 572, Subpt. I, Fig. 43 EC01AU91.172...

  17. 49 CFR Appendix - Figures to Subpart I of Part 572

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... conditions. Pt. 572, Subpt. I, Figs. Figures to Subpart I of Part 572 Pt. 572, Subpt. I, Fig. 40 EC01AU91.169 Pt. 572, Subpt. I, Fig. 41 EC01AU91.170 Pt. 572, Subpt. I, Fig. 42 EC01AU91.171 Pt. 572, Subpt. I, Fig. 43 EC01AU91.172...

  18. 49 CFR Appendix - Figures to Subpart I of Part 572

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... conditions. Pt. 572, Subpt. I, Figs. Figures to Subpart I of Part 572 Pt. 572, Subpt. I, Fig. 40 EC01AU91.169 Pt. 572, Subpt. I, Fig. 41 EC01AU91.170 Pt. 572, Subpt. I, Fig. 42 EC01AU91.171 Pt. 572, Subpt. I, Fig. 43 EC01AU91.172...

  19. 49 CFR Appendix - Figures to Subpart I of Part 572

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... conditions. Pt. 572, Subpt. I, Figs. Figures to Subpart I of Part 572 Pt. 572, Subpt. I, Fig. 40 EC01AU91.169 Pt. 572, Subpt. I, Fig. 41 EC01AU91.170 Pt. 572, Subpt. I, Fig. 42 EC01AU91.171 Pt. 572, Subpt. I, Fig. 43 EC01AU91.172...

  20. NHEXAS PHASE I REGION 5 STUDY

    EPA Science Inventory

    The National Human Exposure Assessment Survey (NHEXAS) is a federal interagency research effort coordinated by the Environmental Protection Agency (EPA), Office of Research and Development (ORD). Phase I consists of demonstration/scoping studies using probability-based sampling d...

  1. [The oral problems of queen Elizabeth I].

    PubMed

    Eijkman, M A J

    2012-05-01

    Queen Elizabeth I of England (1533-1603), probably the most famous English Queen ever, had persistent oral problems. Her oral problems were so serious that they probably hampered the Queen in the performance of her tasks. PMID:22667195

  2. Empirical typology of bipolar I mood episodes*

    PubMed Central

    Solomon, David A.; Leon, Andrew C.; Endicott, Jean; Coryell, William H.; Li, Chunshan; Fiedorowicz, Jess G.; Keller, Martin B.

    2009-01-01

    Background Much remains unknown about the phenomenology of bipolar I disorder. Aims To determine the type of bipolar I mood episodes that occur over time, and their relative frequency. Method A total of 219 individuals with Research Diagnostic Criteria bipolar I disorder were prospectively followed for up to 25 years (median 20 years). Psychopathology was assessed with the Longitudinal Interval Follow-up Evaluation. Results Overall, 1208 mood episodes were prospectively observed. The episodes were empirically classified as follows: major depression, 30.9% (n = 373); minor depression, 13.0% (n = 157); mania, 20.4% (n = 246); hypomania, 10.4% (n = 126); cycling, 17.3% (n = 210); cycling plus mixed state, 7.8% (n = 94); and mixed, 0.2% (n = 2). Conclusions Cycling episodes constituted 25% of all episodes. Work groups revising ICD–10 and DSM–IV should add a category for bipolar I cycling episode. PMID:19949203

  3. Should I Exercise During My Pregnancy?

    MedlinePlus

    ... Bar Home Current Issue Past Issues Should I Exercise During My Pregnancy? Past Issues / Winter 2008 Table ... to a healthy weight. 5 steps for safe exercise during pregnancy: Choose moderate activities unlikely to injure, ...

  4. Radioactive Iodine (I-131) Therapy for Hyperthyroidism

    MedlinePlus

    ... Iodine (I-131) Therapy Radioiodine therapy is a nuclear medicine treatment for an overactive thyroid, a condition ... locally overactive in producing too much thyroid hormone. Nuclear medicine is a branch of medical imaging that ...

  5. Challenge of COPD: Am I at Risk?

    MedlinePlus

    ... please turn JavaScript on. Feature: The Challenge of COPD Am I at Risk? Past Issues / Fall 2014 ... or the American Lung Association's COPD information section. COPD Learn More Breathe Better ® Program The COPD Learn ...

  6. IGRINS observations toward Class I disk sources

    NASA Astrophysics Data System (ADS)

    Lee, Seokho; Lee, Jeong-Eun; Park, Sunkyung; Jaffe, Daniel T.; Lee, Jae-Joon

    2015-08-01

    We present the high-resolution Immersion GRating INfrared spectrograph (IGRINS) spectra of Class I sources, including IRAS03445+3242 and IRAS04239+2436. These sources show the evidence of Keplerian disks; the broadened CO overtone (Δ v=2) transitions in emission and neutral metal lines (Mg I, Fe I, and Al I) in absorption. The thin Keplerian disk with a rotational velocity of ~100 km s-1 and a gas temperature of 5000 K at the innermost annulus can reproduce the CO overtone transitions including the bandhead emission. The temperature is assumed to have a power-law distribution with p=0.5. The outer colder disk or the envelope needs to fit the narrow absorption features overlaid on the broad emission lines in the CO overtone transitions. Other atomic and molecular emission lines likely radiated from the disk and/or wind are also detected.

  7. Future Trends for ``i-Learning'' Experiences

    NASA Astrophysics Data System (ADS)

    Elia, Gianluca; Poce, Antonella

    This chapter aims at shaping possible directions along with imagining the development and the evolution of the “i-Learning” paradigm. Specifically, three interdependent classes of future trends are depicted: technology-related trends and organization-related trends.

  8. Regulation of type I interferon responses

    PubMed Central

    Ivashkiv, Lionel B.; Donlin, Laura T.

    2014-01-01

    Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. Canonical type I IFN signalling activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway, leading to transcription of IFN-stimulated genes (ISGs). Host, pathogen and environmental factors regulate the responses of cells to this signalling pathway and thus calibrate host defences while limiting tissue damage and preventing autoimmunity. Here, we summarize the signalling and epigenetic mechanisms that regulate type I IFN-induced STAT activation and ISG transcription and translation. These regulatory mechanisms determine the biological outcomes of type I IFN responses and whether pathogens are cleared effectively or chronic infection or autoimmune disease ensues. PMID:24362405

  9. Topoisomerase I-mediated DNA damage.

    PubMed

    Pourquier, P; Pommier, Y

    2001-01-01

    Topoisomerase I is a ubiquitous and essential enzyme in multicellular organisms. It is involved in multiple DNA transactions including DNA replication, transcription, chromosome condensation and decondensation, and probably DNA recombination. Besides its activity of DNA relaxation necessary to eliminate torsional stresses associated with these processes, topoisomerase I may have other functions related to its interaction with other cellular proteins. Topoisomerase I is the target of the novel anticancer drugs, the camptothecins. Recently a broad range of physiological and environmentally-induced DNA modifications have also been shown to poison topoisomerases. This review summarizes the various factors that enhance or suppress top1 cleavage complexes and discusses the significance of such effects. We also review the different mechanisms that have been proposed for the repair of topoisomerase I-mediated DNA lesions. PMID:11034544

  10. Genetics Home Reference: mucopolysaccharidosis type I

    MedlinePlus

    ... accumulation of GAGs within cells, specifically inside the lysosomes . Lysosomes are compartments in the cell that digest and ... that cause molecules to build up inside the lysosomes, including MPS I, are called lysosomal storage disorders. ...

  11. Procedures for RIA I-125 waste disposal

    SciTech Connect

    Hidalgo, J.U.; Shepard, E.S.; Ball, J.M.; Colomb, K.D.

    1982-04-01

    I-125 can be effectively removed from coated tubes and plastic beads used as solid-phase separators by a 50% household bleach solution. This technique enables the user to dispose of these separators into common trash.

  12. Production of SSM/I data sets

    NASA Technical Reports Server (NTRS)

    Wentz, Frank J.

    1992-01-01

    This Final Report is a summary of the work that was performed under Contract NAS8-38075 between NASA Marshall Space Flight Center and Remote Sensing Systems from September 1989 to September 1992. The primary accomplishment was the delivery of Special Sensor Microwave/Imager (SSM/I) data tapes containing sensor and geophysical products. In all, 515 tapes (80 gigabytes) were delivered. These tapes contained the F08 SSM/I data for the period from July 1988 through December 1991 and the F10 SSM/I data for the period from December 1990 through December 1991. For the F08 SSM/I, a data inventory was compiled and an engineering assessment was done. Ephemeris tables for the F08 and F10 spacecrafts were computed. Scientific studies on the oceanic wind vector and water vapor field were published, and color atlases of monthly ocean products were produced. This investigation was part of NASA's WETNET program.

  13. The GALFA-H I Survey

    NASA Astrophysics Data System (ADS)

    Peek, J. E. G.; Begum, A.; Douglas, K. A.; Gibson, S. J.; Grcevich, J.; Heiles, C.; Korpela, E. J.; Lee, M.; Putman, M.; Saul, D. R.; Stanimirović, S.

    2010-12-01

    We present the GALFA-H I survey. GALFA-H I is an ongoing survey of neutral hydrogen (H I) in the Galaxy conducted at the 305 m Arecibo telescope. We briefly discuss the parameters of the survey, and the philosophy behind our observational strategy. We discuss the GALFA-H I survey in the context of other large area HI surveys, past, present, and future, and compare it to these surveys in terms of various observational parameters. We give a very brief overview of all the surveys being conducted with the ALFA instrument and discuss the importance of our commensal partnerships with a subset of these surveys. We discuss our current survey coverage, and describe our current and future data availability. We also briefly describe some of the science being conducted with the ongoing survey.

  14. Diagnosing lysosomal storage disorders: mucopolysaccharidosis type I.

    PubMed

    Johnson, Britt A; Dajnoki, Angela; Bodamer, Olaf A

    2015-01-01

    Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder due to deficiency of alpha iduronidase (IDUA). Progressive storage of dermatan and heparan sulfate throughout the body lead to a multiorgan presentation including short stature, dysostosis multiplex, corneal clouding, hearing loss, coarse facies, hepatosplenomegaly, and intellectual disability. Diagnosis of MPS I is based on IDUA enzyme analysis in leukocytes or dried blood spots (DBS) followed by molecular confirmation of the IDUA gene mutations in individuals with low enzyme activity. The advent of mass spectrometry methods for enzyme analysis in DBS has enabled high-throughput screening for MPS I in symptomatic individuals and newborn infants. The following unit provides the detailed analytical protocol for measurement of IDUA activity in DBS using tandem mass spectrometry. PMID:25599668

  15. Assessing DNA structures with 125I radioprobing.

    PubMed

    Gaynutdinov, Timur I; Neumann, Ronald D; Panyutin, Igor G

    2010-01-01

    Iodine-125 radioprobing is based on incorporation of radioiodine into a defined position in a nucleic acid molecule. Decay of (125)I results in the emission of multiple, low-energy Auger electrons that, along with positively charged residual daughter nuclide, produce DNA strand breaks. The probability of such strand breaks at a given nucleotide is in inverse proportion to the distance from the (125)I atom to the sugar of that nucleotide. Therefore, conclusions can be drawn about the conformation or folding of a DNA or RNA molecule based on the distribution of (125)I decay-induced strand breaks. Here we describe in detail the application (125)I radioprobing for studying the conformation of quadruplex structures, and discuss the advantages and limitations of the method. PMID:20012420

  16. In memory of I. K. Lopatin

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Life and works of one of the most prominent leaf beetle systematist, I. K. Lopatin, is described. Complete list of his publications is provided along with list of taxa that he described and taxa that were named after him....

  17. Tositumomab and Iodine I 131 Tositumomab

    Cancer.gov

    This page contains brief information about tositumomab and iodine I 131 tositumomab and a collection of links to more information about the use of this drug combination, research results, and ongoing clinical trials.

  18. <i>DShaper>: An approach for handling missing low-<i>Q> data in pair distribution function analysis of nanostructured systems

    SciTech Connect

    Olds, Daniel; Wang, Hsiu -Wen; Page, Katharine

    2015-01-01

    This study discusses the potential problems and currently available solutions in modeling powder-diffraction-based pair distribution function (PDF) data from systems where morphological feature information content includes distances in the nanometre length scale, such as finite nanoparticles, nanoporous networks and nanoscale precipitates in bulk materials. The implications of an experimental finite minimum<i>Q>value are reviewed by simulation, which also demonstrates the advantages of combining PDF data with small-angle scattering data. A simple Fortran90 code, <i>DShaper>, is introduced, which may be incorporated into PDF data fitting routines in order to approximate the so-called `shape function' for any atomistic model.

  19. Interaction of the intron-encoded mobility endonuclease I-PpoI with its target site.

    PubMed Central

    Ellison, E L; Vogt, V M

    1993-01-01

    Endonucleases encoded by mobile group I introns are highly specific DNases that induce a double-strand break near the site to which the intron moves. I-PpoI from the acellular slime mold Physarum polycephalum mediates the mobility of intron 3 (Pp LSU 3) in the extrachromosomal nuclear ribosomal DNA of this organism. We showed previously that cleavage by I-PpoI creates a four-base staggered cut near the point of intron insertion. We have now characterized several further properties of the endonuclease. As determined by deletion analysis, the minimal target site recognized by I-PopI was a sequence of 13 to 15 bp spanning the cleavage site. The purified protein behaved as a globular dimer in sedimentation and gel filtration. In gel mobility shift assays in the presence of EDTA, I-PpoI formed a stable and specific complex with DNA, dissociating with a half-life of 45 min. By footprinting and interference assays with methidiumpropyl-EDTA-iron(II), I-PpoI contacted a 22- to 24-bp stretch of DNA. The endonuclease protected most of the purines found in both the major and minor grooves of the DNA helix from modification by dimethyl sulfate (DMS). However, the reactivity to DMS was enhanced at some purines, suggesting that binding leads to a conformational change in the DNA. The pattern of DMS protection differed fundamentally in the two partially symmetrical halves of the recognition sequence. Images PMID:8246971

  20. The origin of I in soil and the 129I problem.

    PubMed

    Cohen, B L

    1985-08-01

    It is widely believed that the I in soil is derived from the I in oceans by evaporating-atmospheric transport-washout by rain over land, rather than from the I in rock when the latter is weathered into soil. Since human I burdens are derived largely from soil by plant root uptake into food, this implies that the specific activity of 129I in the I of human thyroids will be the same as that in the oceans, whereas it would be similar to that in rock (much lower) if the I in soil were derived from weathering of rock as is the case for other heavy trace elements. The bases for the oceanic origin theory are analysed and found not to be in accord with modern data. Recent data shows no correlation between concentration of I in soil and proximity to oceans, which argues strongly against the oceanic origin theory. Some problems with long-distance atmospheric transport are pointed out. It is shown that the balance between I input to soil during soil formation by rock weathering and output from soil by erosion leaves little room for contributions from oceanic sources. It is concluded that only a small fraction of the I in soil is of oceanic origin. Most estimates of very long-term effects of 129I on human health are therefore several times too high. PMID:4019198

  1. 78 FR 32530 - Notice of Final Federal Agency Action on Proposed Highway in Georgia the Northwest I-75/I-575...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... Northwest I-75/I-575 Corridor, Cobb and Cherokee Counties, Georgia (Atlanta Metropolitan Area) AGENCY... I-75 to Sixes Road on I-575) located in Cobb and Cherokee Counties, Georgia. The approximate...

  2. Dilute nitride and GaAs n-i-p-i solar cells

    PubMed Central

    2012-01-01

    We demonstrate for the first time the operation of GaInNAs and GaAs n-i-p-i doping solar cells with ion-implanted selective contacts. Multiple layers of alternate doping are grown by molecular beam epitaxy to form the n-i-p-i structure. After growth, vertical selective contacts are fabricated by Mg and Si ion implantation, followed by rapid thermal annealing treatment and fabrication into circular mesa cells. As means of characterisation, spectral response and illuminated current–voltage (I-V) were measured on the samples. The spectral response suggests that all horizontal layers are able to contribute to the photocurrent. Performance of the devices is discussed with interest in the n-i-p-i structure as a possible design for the GaInP/GaAs/GaInNAs tandem solar cell. PMID:23167964

  3. Dilute nitride and GaAs n-i-p-i solar cells.

    PubMed

    Mazzucato, Simone; Royall, Benjamin; Ketlhwaafetse, Richard; Balkan, Naci; Salmi, Joel; Puustinen, Janne; Guina, Mircea; Smith, Andy; Gwilliam, Russell

    2012-01-01

    We demonstrate for the first time the operation of GaInNAs and GaAs n-i-p-i doping solar cells with ion-implanted selective contacts. Multiple layers of alternate doping are grown by molecular beam epitaxy to form the n-i-p-i structure. After growth, vertical selective contacts are fabricated by Mg and Si ion implantation, followed by rapid thermal annealing treatment and fabrication into circular mesa cells. As means of characterisation, spectral response and illuminated current-voltage (I-V) were measured on the samples. The spectral response suggests that all horizontal layers are able to contribute to the photocurrent. Performance of the devices is discussed with interest in the n-i-p-i structure as a possible design for the GaInP/GaAs/GaInNAs tandem solar cell. PMID:23167964

  4. I-NERI 2004 Annual Report

    SciTech Connect

    2004-01-01

    The International Nuclear Energy Research Initiative (I-NERI) supports the National Energy Policy by conducting research to advance the state of nuclear science and technology in the United States (U.S.). I-NERI sponsors innovative scientific and engineering research and development (R&D) in cooperation with participating countries. The R&D research performed under the I-NERI umbrella addresses the key issues affecting the future of nuclear energy and its global deployment. I-NERI research is directed towards improving cost performance, increasing proliferation resistance, enhancing safety, and improving the waste management of future nuclear energy systems. This I-NERI 2004 Annual Report serves to inform interested parties on the program's organization, progress of the collaborative research projects, and future planning for the program. The report covers the four years of I-NERI activity since the program's inception in fiscal year (FY) 2001. The motivation and series of events that led to the creation of the I-NERI program are discussed in Section 2. The participating countries in current I-NERI collaborative agreements are also presented. Section 3 presents an overview of the I-NERI goals and objectives, a work scope summary for the collaborative projects, and a summary of research project awards through the end of FY 2004. It also includes FY 2005 accomplishments and planned FY 2005 activities. A summary of programmatic accomplishments is presented in Section 4. Also included is a summary of new and existing projects, an overview of the I-NERI program funding, and the new collaborations anticipated in FY 2005. The R&D work scope for current I-NERI collaborative projects with Canada, France, Japan, the Organization for Economic Cooperation and Development/Nuclear Energy Agency (OECD/NEA), and the Republic of Korea are presented in Sections 5 through 9, respectively. For each participating country, an index of projects and a summary of FY 2004 technical

  5. John Dewey's Visits to Hawai'i

    ERIC Educational Resources Information Center

    McEwan, Hunter

    2015-01-01

    John Dewey visited Hawai'i on three separate occasions. Of all three trips, by far the most important, as far as Dewey's influence on education in Hawai'i is concerned, was in 1899 when he came with his wife, Alice Chipman Dewey, to help launch the University Extension program in Honolulu. The Deweys' second trip was a very brief one--twenty years…

  6. IT Does Not Love iPads

    ERIC Educational Resources Information Center

    Fredette, Michelle

    2013-01-01

    On many campuses, iPads have taken over the hearts and minds of everyone. Everyone, that is, except the IT department. These sexy tablets might be the apple of faculty and students' eyes, but for IT directors and their staffs, working with iPads in an enterprise network environment is not the stuff of a love affair. To state the problem…

  7. Structural Variation in Bacterial Glyoxalase I Enzymes

    PubMed Central

    Suttisansanee, Uthaiwan; Lau, Kelvin; Lagishetty, Satyanarayana; Rao, Krishnamurthy N.; Swaminathan, Subramanyam; Sauder, J. Michael; Burley, Stephen K.; Honek, John F.

    2011-01-01

    The glyoxalase system catalyzes the conversion of toxic, metabolically produced α-ketoaldehydes, such as methylglyoxal, into their corresponding nontoxic 2-hydroxycarboxylic acids, leading to detoxification of these cellular metabolites. Previous studies on the first enzyme in the glyoxalase system, glyoxalase I (GlxI), from yeast, protozoa, animals, humans, plants, and Gram-negative bacteria, have suggested two metal activation classes, Zn2+ and non-Zn2+ activation. Here, we report a biochemical and structural investigation of the GlxI from Clostridium acetobutylicum, which is the first GlxI enzyme from Gram-positive bacteria that has been fully characterized as to its three-dimensional structure and its detailed metal specificity. It is a Ni2+/Co2+-activated enzyme, in which the active site geometry forms an octahedral coordination with one metal atom, two water molecules, and four metal-binding ligands, although its inactive Zn2+-bound form possesses a trigonal bipyramidal geometry with only one water molecule liganded to the metal center. This enzyme also possesses a unique dimeric molecular structure. Unlike other small homodimeric GlxI where two active sites are located at the dimeric interface, the C. acetobutylicum dimeric GlxI enzyme also forms two active sites but each within single subunits. Interestingly, even though this enzyme possesses a different dimeric structure from previously studied GlxI, its metal activation characteristics are consistent with properties of other GlxI. These findings indicate that metal activation profiles in this class of enzyme hold true across diverse quaternary structure arrangements. PMID:21914803

  8. NASA'S MSFC Welding Development for Ares I

    NASA Technical Reports Server (NTRS)

    Ding, Jeff

    2008-01-01

    This slide presentation reviews the development of welding for the Ares I launch vehicle. Shown are views of the Ares I and Ares 5, and comparisons with the space shuttle and Saturn V launch vehicles. The elements, and the contractor charged with developing each is shown. The various types of welding capabilities are reviewed. Pictures of the various welding systems available at Marshall Space Flight Center are shown.

  9. Functional domains in Fok I restriction endonuclease.

    PubMed Central

    Li, L; Wu, L P; Chandrasegaran, S

    1992-01-01

    The PCR was used to alter transcriptional and translational signals surrounding the Flavobacterium okeanokoites restriction endonuclease (fokIR) gene, so as to achieve high expression in Escherichia coli. By changing the ribosome-binding site sequence preceding the fokIR gene to match the consensus E. coli signal and by placing a positive retroregulator stem-loop sequence downstream of the gene, Fok I yield was increased to 5-8% of total cellular protein. Fok I was purified to homogeneity with phosphocellulose, DEAE-Sephadex, and gel chromatography, yielding 50 mg of pure Fok I endonuclease per liter of culture medium. The recognition and cleavage domains of Fok I were analyzed by trypsin digestion. Fok I in the absence of a DNA substrate cleaves into a 58-kDa carboxyl-terminal and 8-kDa amino-terminal fragment. The 58-kDa fragment does not bind the DNA substrate. Fok I in the presence of a DNA substrate cleaves into a 41-kDa amino-terminal fragment and a 25-kDa carboxyl-terminal fragment. On further digestion, the 41-kDa fragment degrades into 30-kDa amino-terminal and 11-kDa carboxyl-terminal fragments. The cleaved fragments both bind DNA substrates, as does the 41-kDa fragment. Gel-mobility-shift assays indicate that all the protein contacts necessary for the sequence-specific recognition of DNA substrates are encoded within the 41-kDa fragment. Thus, the 41-kDa amino-terminal fragment constitutes the Fok I recognition domain. The 25-kDa fragment, purified by using a DEAE-Sephadex column, cleaves nonspecifically both methylated (pACYCfokIM) and nonmethylated (pTZ19R) DNA substrates in the presence of MgCl2. Thus, the 25-kDa carboxyl-terminal fragment constitutes the Fok I cleavage domain. Images PMID:1584761

  10. Hawai'i: The Aloha State

    ERIC Educational Resources Information Center

    Klein, Edward F.

    2009-01-01

    August 21, 2009, marks the 50th anniversary of the entry of the 50th state into the United States of America. All the states have their stories, but as a string of islands in the vast Pacific Ocean, more than 2,000 miles from any other land mass, Hawai'i has a story that is unique in many ways. Consider, for example, that Hawai'i has two official…

  11. Structure and function of mitochondrial complex I.

    PubMed

    Wirth, Christophe; Brandt, Ulrich; Hunte, Carola; Zickermann, Volker

    2016-07-01

    Proton-pumping NADH:ubiquinone oxidoreductase (complex I) is the largest and most complicated enzyme of the respiratory chain. Fourteen central subunits represent the minimal form of complex I and can be assigned to functional modules for NADH oxidation, ubiquinone reduction, and proton pumping. In addition, the mitochondrial enzyme comprises some 30 accessory subunits surrounding the central subunits that are not directly associated with energy conservation. Complex I is known to release deleterious oxygen radicals (ROS) and its dysfunction has been linked to a number of hereditary and degenerative diseases. We here review recent progress in structure determination, and in understanding the role of accessory subunits and functional analysis of mitochondrial complex I. For the central subunits, structures provide insight into the arrangement of functional modules including the substrate binding sites, redox-centers and putative proton channels and pump sites. Only for two of the accessory subunits, detailed structures are available. Nevertheless, many of them could be localized in the overall structure of complex I, but most of these assignments have to be considered tentative. Strikingly, redox reactions and proton pumping machinery are spatially completely separated and the site of reduction for the hydrophobic substrate ubiquinone is found deeply buried in the hydrophilic domain of the complex. The X-ray structure of complex I from Yarrowia lipolytica provides clues supporting the previously proposed two-state stabilization change mechanism, in which ubiquinone redox chemistry induces conformational states and thereby drives proton pumping. The same structural rearrangements may explain the active/deactive transition of complex I implying an integrated mechanistic model for energy conversion and regulation. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26921811

  12. Enter the iPad (or Not?)

    ERIC Educational Resources Information Center

    Waters, John K.

    2010-01-01

    Few computing devices have sparked the burning gizmo lust ignited by the iPad. Apple's latest entry into the tablet PC market didn't generate much heat when it was first unveiled in January, but by April 3, the day of the official release, feverish customers were mobbing Apple stores. The company claims to have sold 300,000 iPads by midnight on…

  13. Type I interferon dysregulation and neurological disease.

    PubMed

    McGlasson, Sarah; Jury, Alexa; Jackson, Andrew; Hunt, David

    2015-09-01

    Type I interferon is an essential component of the brain's innate immune defence, conferring protection against viral infection. Recently, dysregulation of the type I interferon pathway has been implicated in the pathogenesis of a spectrum of neuroinfectious and neuroinflammatory disorders. Underactivity of the type I interferon response is associated with a predisposition to herpes simplex encephalitis. Conversely, a group of 'interferonopathic' disorders, characterized by severe neuroinflammation and overactivity of type I interferon, has been described. Elucidation of the genetic basis of these Mendelian neuroinflammatory diseases has uncovered important links between nucleic acid sensors, innate immune activation and neuroinflammatory disease. These mechanisms have an important role in the pathogenesis of more common polygenic diseases that can affect the brain, such as lupus and cerebral small vessel disease. In this article, we review the spectrum of neurological disease associated with type I interferon dysregulation, as well as advances in our understanding of the molecular and cellular pathogenesis of these conditions. We highlight the potential utility of type I interferon as both a biomarker and a therapeutic target in neuroinflammatory disease. PMID:26303851

  14. Type I restriction enzymes and their relatives

    PubMed Central

    Loenen, Wil A. M.; Dryden, David T. F.; Raleigh, Elisabeth A.; Wilson, Geoffrey G.

    2014-01-01

    Type I restriction enzymes (REases) are large pentameric proteins with separate restriction (R), methylation (M) and DNA sequence-recognition (S) subunits. They were the first REases to be discovered and purified, but unlike the enormously useful Type II REases, they have yet to find a place in the enzymatic toolbox of molecular biologists. Type I enzymes have been difficult to characterize, but this is changing as genome analysis reveals their genes, and methylome analysis reveals their recognition sequences. Several Type I REases have been studied in detail and what has been learned about them invites greater attention. In this article, we discuss aspects of the biochemistry, biology and regulation of Type I REases, and of the mechanisms that bacteriophages and plasmids have evolved to evade them. Type I REases have a remarkable ability to change sequence specificity by domain shuffling and rearrangements. We summarize the classic experiments and observations that led to this discovery, and we discuss how this ability depends on the modular organizations of the enzymes and of their S subunits. Finally, we describe examples of Type II restriction–modification systems that have features in common with Type I enzymes, with emphasis on the varied Type IIG enzymes. PMID:24068554

  15. Apolipoprotein A-I and Cancer

    PubMed Central

    Zamanian-Daryoush, Maryam; DiDonato, Joseph A.

    2015-01-01

    High-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I), the predominant protein in plasma HDL, have long been the focus of intense studies in the field of atherosclerosis and cardiovascular disease. ApoA-I, in large part, is responsible for HDL assembly and its main atheroprotective function, that of shuttling excess cholesterol from peripheral tissues to the liver for excretion (reverse cholesterol transport). Recently, a protective role for HDL in cancer was suggested from several large clinical studies where an inverse relationship between plasma HDL-cholesterol (HDL-C) levels and risk of developing cancer was noted. This notion has now been tested and found to be supported in mouse tumor studies, where increasing levels of apoA-I/HDL were discovered to protect against tumor development and provision of human apoA-I was therapeutic against established tumors. This mini-review discusses the emerging role of apoA-I in tumor biology and its potential as cancer therapeutic. PMID:26617517

  16. Fast CsI-phoswich detector

    DOEpatents

    Langenbrunner, J.R.

    1996-05-07

    An improved phoswich radiation detector used pure CsI crystal and a fast plastic scintillator and a single photomultiplier tube. The plastic is arranged to receive incident radiation, and that which passed through then strikes the CsI crystal. Scintillation light from both the plastic and CsI crystal are applied to the photomultiplier tube, with the light from the plastic passing through the crystal without absorption therein. Electronics are provided for analyzing the output of the photomultiplier tube to discriminate responses due to the plastic and the CsI crystal, through short gate and long gate integration, to produce results which are indicative of the characteristics of the different types of incident radiation, even in the presence of large amounts of radiation. The phoswich detector has excellent timing resolution. The scintillators of the CsI- phoswich were chosen for their fast risetimes, of about 3 ns for NE102A, and 30 ns for the pure CsI. 5 figs.

  17. Structure of a eukaryotic thiaminase I

    PubMed Central

    Kreinbring, Cheryl A.; Remillard, Stephen P.; Hubbard, Paul; Brodkin, Heather R.; Leeper, Finian J.; Hawksley, Dan; Lai, Elaine Y.; Fulton, Chandler; Petsko, Gregory A.; Ringe, Dagmar

    2014-01-01

    Thiaminases, enzymes that cleave vitamin B1, are sporadically distributed among prokaryotes and eukaryotes. Thiaminase I enzymes catalyze the elimination of the thiazole ring moiety from thiamin through substitution of the methylene group with a nitrogenous base or sulfhydryl compound. In eukaryotic organisms, these enzymes are reported to have much higher molecular weights than their bacterial counterparts. A thiaminase I of the single-celled amoeboflagellate Naegleria gruberi is the only eukaryotic thiaminase I to have been cloned, sequenced, and expressed. Here, we present the crystal structure of N. gruberi thiaminase I to a resolution of 2.8 Å, solved by isomorphous replacement and pseudo–two-wavelength multiwavelength anomalous diffraction and refined to an R factor of 0.231 (Rfree, 0.265). This structure was used to solve the structure of the enzyme in complex with 3-deazathiamin, a noncleavable thiamin analog and enzyme inhibitor (2.7 Å; R, 0.233; Rfree, 0.267). These structures define the mode of thiamin binding to this class of thiaminases and indicate the involvement of Asp272 as the catalytic base. This enzyme is able to use thiamin as a substrate and is active with amines such as aniline and veratrylamine as well as sulfhydryl compounds such as l-cysteine and β-mercaptoethanol as cosubstrates. Despite significant differences in polypeptide sequence and length, we have shown that the N. gruberi thiaminase I is homologous in structure and activity to a previously characterized bacterial thiaminase I. PMID:24351929

  18. Fast CsI-phoswich detector

    DOEpatents

    Langenbrunner, James R.

    1996-01-01

    An improved phoswich radiation detector used pure CsI crystal and a fast plastic scintillator and a single photomultiplier tube. The plastic is arranged to receive incident radiation, and that which passed through then strikes the CsI crystal. Scintillation light from both the plastic and CsI crystal are applied to the photomultiplier tube, with the light from the plastic passing through the crystal without absorption therein. Electronics are provided for analyzing the output of the photomultiplier tube to discriminate responses due to the plastic and the CsI crystal, through short gate and long gate integration, to produce results which are indicative of the characteristics of the different types of incident radiation, even in the presence of large amounts of radiation. The phoswich detector has excellent timing resolution. The scintillators of the CsI- phoswich were chosen for their fast risetimes, of about 3 ns for NE102A, and 30 ns for the pure CsI.

  19. Complex-I-ty in aging

    PubMed Central

    Stork, Devon A.

    2016-01-01

    The role of mitochondrial complex I in aging has been studied in both C. elegans and Drosophila, where RNAi knock down of specific complex I subunits has been shown to extend lifespan. More recently, studies in Drosophila have shown that an increase in mitochondrial activity, including complex I-like activity, can also slow aging. In this review, we discuss this apparent paradox. Improved maintenance of mitochondrial activity, mitochondrial homeostasis, may be responsible for lifespan extension in both cases. Decreased electron transport chain activity caused by reducing complex I subunit expression prompts an increase in stress response signaling that leads to enhanced mitochondrial homeostasis during aging. Increased complex I activity, as well as mitochondrial biogenesis, is expected to both directly counteract the decline in mitochondrial health that occurs during aging and may also increase cellular NAD+ levels, which have been linked to mitochondrial homeostatic mechanisms through activation of sirtuins. We suggest that manipulations that increase or decrease complex I activity both converge on improved mitochondrial homeostasis during aging, resulting in prolonged lifespan. PMID:24961226

  20. Differential requirement for <i>irf>8 in formation of embryonic and adult macrophages in zebrafish

    SciTech Connect

    Shiau, Celia E.; Kaufman, Zoe; Meireles, Ana M.; Talbot, William S.

    2015-01-23

    Interferon regulatory factor 8 (Irf8) is critical for mammalian macrophage development and innate immunity, but its role in teleost myelopoiesis remains incompletely understood. Specifically, genetic tools to analyze the role of <i>irf>8 in zebrafish macrophage development at larval and adult stages are lacking. In this study, we generated <i>irf>8 null mutants in zebrafish using TALEN-mediated targeting. Our analysis defines different requirements for <i>irf>8 at different stages. <i>irf>8 is required for formation of all macrophages during primitive and transient definitive hematopoiesis, but not during adult-phase definitive hematopoiesis starting at 5-6 days postfertilization. At early stages, <i>irf>8 mutants have excess neutrophils and excess cell death in pu.1-expressing myeloid cells. Macrophage fates were recovered in <i>irf>8 mutants after wildtype <i>irf>8 expression in neutrophil and macrophage lineages, suggesting that <i>irf>8 regulates macrophage specification and survival. In juvenile <i>irf>8 mutant fish, mature macrophages are present, but at numbers significantly reduced compared to wildtype, indicating an ongoing requirement for <i>irf>8 after embryogenesis. As development progresses, tissue macrophages become apparent in zebrafish <i>irf>8 mutants, with the possible exception of microglia. Our study defines distinct requirement for <i>irf>8 in myelopoiesis before and after transition to the adult hematopoietic system.

  1. 30 CFR 57.22222 - Ventilation materials (I-A, I-B, I-C, II-A, III, V-A, and V-B mines).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....22222 Ventilation materials (I-A, I-B, I-C, II-A, III, V-A, and V-B mines). Brattice cloth and ventilation tubing shall be approved by MSHA in accordance with 30 CFR part 7, or shall bear a BC or VT... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Ventilation materials (I-A, I-B, I-C, II-A,...

  2. 30 CFR 57.22202 - Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... reverse airstream shall be approved by MSHA under the appliable requirements of 30 CFR part 18; (2) Drive... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Main fans (I-A, I-B, I-C, II-A, III, V-A, and V... Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines). (a) Main fans shall be— (1) Installed on...

  3. 30 CFR 57.22202 - Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... reverse airstream shall be approved by MSHA under the appliable requirements of 30 CFR part 18; (2) Drive... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Main fans (I-A, I-B, I-C, II-A, III, V-A, and V... Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines). (a) Main fans shall be— (1) Installed on...

  4. 30 CFR 57.22202 - Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... reverse airstream shall be approved by MSHA under the appliable requirements of 30 CFR part 18; (2) Drive... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Main fans (I-A, I-B, I-C, II-A, III, V-A, and V... Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines). (a) Main fans shall be— (1) Installed on...

  5. Density- and wavefunction-normalized Cartesian spherical harmonics for <i>l> ≤ 20

    SciTech Connect

    Michael, J. Robert; Volkov, Anatoliy

    2015-03-01

    The widely used pseudoatom formalism in experimental X-ray charge-density studies makes use of real spherical harmonics when describing the angular component of aspherical deformations of the atomic electron density in molecules and crystals. The analytical form of the density-normalized Cartesian spherical harmonic functions for up to <i>l> ≤ 7 and the corresponding normalization coefficients were reported previously by Paturle & Coppens. It was shown that the analytical form for normalization coefficients is available primarily forl ≤ 4. Only in very special cases it is possible to derive an analytical representation of the normalization coefficients for 4 < <i>l> ≤ 7. In most cases for <i>l> > 4 the density normalization coefficients were calculated numerically to within seven significant figures. In this study we review the literature on the density-normalized spherical harmonics, clarify the existing notations, use the Paturle–Coppens method in the Wolfram <i>Mathematica>software to derive the Cartesian spherical harmonics for <i>l> ≤ 20 and determine the density normalization coefficients to 35 significant figures, and computer-generate a Fortran90 code. The article primarily targets researchers who work in the field of experimental X-ray electron density, but may be of some use to all who are interested in Cartesian spherical harmonics.

  6. Nutrient requirements and growth physiology of the photoheterotrophic Acidobacterium, <i>Chloracidobacterium thermophilumi>

    SciTech Connect

    Tank, Marcus; Bryant, Donald A.

    2015-03-27

    A novel thermophilic, microaerophilic, anoxygenic, and chlorophototrophic member of the phylum <i>Acidobacteria, Chloracidobacterium thermophilumi> strain BT, was isolated from a cyanobacterial enrichment culture derived from microbial mats associated with Octopus Spring, Yellowstone National Park, Wyoming. <i>C. thermophilumi> is strictly dependent on light and oxygen and grows optimally as a photoheterotroph at irradiance values between 20 and 50 µmol photons m⁻² s⁻¹. <i>C. thermophilumi> is unable to synthesize branched-chain amino acids (AAs), L-lysine, and vitamin B₁₂, which are required for growth. Although the organism lacks genes for autotrophic carbon fixation, bicarbonate is also required. Mixtures of other AAs and 2-oxoglutarate stimulate growth. As suggested from genomic sequence data, <i>C. thermophilumi> requires a reduced sulfur source such as thioglycolate, cysteine, methionine, or thiosulfate. The organism can be grown in a defined medium at 51° C (Topt; range 44–58°C) in the pH range 5.5–9.5 (pHopt = ~7.0). Using the defined growth medium and optimal conditions, it was possible to isolate new <i>C. thermophilumi> strains directly from samples of hot springs mats in Yellowstone National Park, Wyoming. The new isolates differ from the type strain with respect to pigment composition, morphology in liquid culture, and temperature adaptation.

  7. Groundbased IO [O I] 6300A Observations during the Galileo I24 and I25 and Cassini Encounters

    NASA Technical Reports Server (NTRS)

    Oliverson, R. J.; Morgenthaler, J. P.; Scherb, F.; Harris, W. M.; Smyth, W. H.; Lupie, O. L.; Oegerle, William R. (Technical Monitor)

    2002-01-01

    We report on selected recent spectroscopic observations of Io [OI] 6300Angstrom emission, using the high-resolution (R approximately equal to 120,000) stellar spectrograph at the National Solar Observatory McMath-Pierce telescope. These data were obtained during the Galileo I24 (1999-Oct-11) and I25 (1999-Nov-26) encounters with Io and the Cassini Jupiter encounter (closest approach 2000-Dec-30). The exposure time for each spectrum was 15 minutes, with a 5.2 second x 5.2 second aperture centered on Io. We obtained 102 spectra for the I24 encounter during 1999 October 9-13, 82 spectra for the I25 encounter during 1999 November 24-28, 313 spectra during 2000 December 11-23, and 280 spectra during 2000 December 29-2001 January 21 for the Cassini Jupiter encounter. We showed in a recent paper (Oliversen et al. 2001, JGR, 106, 26183) that this emission allows us to use Io as a localized probe of the three-dimensional plasma torus structure. We will also present preliminary results on selected contemporaneous narrowband [SII]6731A torus images obtained at the McMath-Pierce west auxiliary telescope. We took 136, 112, and 277 torus images during the Galileo I24, Galileo I25 and Cassini Jupiter encounters, respectively. Jupiter was imaged directly onto the CCD through a ND 4 filter and the reflected light was used for guiding. Both sides of the torus were imaged simultaneously when there were no Galilean satellites between 3-8 Jovian radii from Jupiter.

  8. Four RFLPs of the human insulin receptor gene: PstI, KpnI, RsaI (2 RFLPs)

    SciTech Connect

    Cox, N.J.; Spielman, R.S.; Taub, R. ); Kahn, C.R.; Muller-Wieland, D.; Kriauciunas, K.M. )

    1989-01-25

    Fragments were isolated from subclones containing the human insulin receptor cDNA. Probe 1 was a 677 bp XhoI/EcoRI fragment from the {alpha}-subunit region of the insulin receptor cDNA corresponding to nucleotides 334 to 1,011, the putative ligand binding domain. Probe 2 was a 1,599 bp PstI fragment from the {beta}-subunit region of the insulin receptor cDNA corresponding to nucleotides 2,746 to 4,345, encoding the tyrosine kinase domain.

  9. Salt and gene expression: evidence for [Na+]i/[K+]i-mediated signaling pathways.

    PubMed

    Orlov, Sergei N; Hamet, Pavel

    2015-03-01

    Our review focuses on the recent data showing that gene transcription and translation are under the control of signaling pathways triggered by modulation of the intracellular sodium/potassium ratio ([Na+]i/[K+]i). Side-by-side with sensing of osmolality elevation by tonicity enhancer-binding protein (TonEBP, NFAT5), [Na+]i/[K+]i-mediated excitation-transcription coupling may contribute to the transcriptomic changes evoked by high salt consumption. This novel mechanism includes the sensing of heightened Na+ concentration in the plasma, interstitial, and cerebrospinal fluids via augmented Na+ influx in the endothelium, immune system cells, and the subfornical organ, respectively. In these cells, [Na+]i/[K+]i ratio elevation, triggered by augmented Na+ influx, is further potentiated by increased production of endogenous Na+,K+-ATPase inhibitors documented in salt-sensitive hypertension. PMID:25479826

  10. Structure of bacterial respiratory complex I.

    PubMed

    Berrisford, John M; Baradaran, Rozbeh; Sazanov, Leonid A

    2016-07-01

    Complex I (NADH:ubiquinone oxidoreductase) plays a central role in cellular energy production, coupling electron transfer between NADH and quinone to proton translocation. It is the largest protein assembly of respiratory chains and one of the most elaborate redox membrane proteins known. Bacterial enzyme is about half the size of mitochondrial and thus provides its important "minimal" model. Dysfunction of mitochondrial complex I is implicated in many human neurodegenerative diseases. The L-shaped complex consists of a hydrophilic arm, where electron transfer occurs, and a membrane arm, where proton translocation takes place. We have solved the crystal structures of the hydrophilic domain of complex I from Thermus thermophilus, the membrane domain from Escherichia coli and recently of the intact, entire complex I from T. thermophilus (536 kDa, 16 subunits, 9 iron-sulphur clusters, 64 transmembrane helices). The 95Å long electron transfer pathway through the enzyme proceeds from the primary electron acceptor flavin mononucleotide through seven conserved Fe-S clusters to the unusual elongated quinone-binding site at the interface with the membrane domain. Four putative proton translocation channels are found in the membrane domain, all linked by the central flexible axis containing charged residues. The redox energy of electron transfer is coupled to proton translocation by the as yet undefined mechanism proposed to involve long-range conformational changes. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26807915

  11. Induction of Type I Interferons by Bacteria

    PubMed Central

    Monroe, Kathryn M.; McWhirter, Sarah M.; Vance, Russell E.

    2010-01-01

    SUMMARY Type I interferons (IFNs) are secreted cytokines that orchestrate diverse immune responses to infection. Although typically considered to be most important in the response to viruses, type I IFNs are also induced by most, if not all, bacterial pathogens. Although diverse mechanisms have been described, bacterial induction of type I IFNs occurs upon stimulation of two main pathways: (1) Toll-like receptor (TLR) recognition of bacterial molecules such as lipopolysaccharide (LPS); (2) TLR-independent recognition of molecules delivered to the host cell cytosol. Cytosolic responses can be activated by two general mechanisms. First, viable bacteria can secrete stimulatory ligands into the cytosol via specialized bacterial secretion systems. Second, ligands can be released from bacteria that lyse or are degraded. The bacterial ligands that induce the cytosolic pathways remains uncertain in many cases, but appear to include various nucleic acids. In this review, we discuss recent advances in our understanding of how bacteria induce type I interferons and the roles type I IFNs play in host immunity. PMID:20482555

  12. Cold H I in faint dwarf galaxies

    NASA Astrophysics Data System (ADS)

    Patra, Narendra Nath; Chengalur, Jayaram N.; Karachentsev, Igor D.; Kaisin, Serafim S.; Begum, Ayesha

    2016-03-01

    We present the results of a study of the amount and distribution of cold atomic gas, as well its correlation with recent star formation in a sample of extremely faint dwarf irregular galaxies. Our sample is drawn from the Faint Irregular Galaxy GMRT Survey (FIGGS) and its extension, FIGGS2. We use two different methods to identify cold atomic gas. In the first method, line-of-sight H I spectra were decomposed into multiple Gaussian components and narrow Gaussian components were identified as cold H I. In the second method, the brightness temperature (TB ) is used as a tracer of cold H I. We find that the amount of cold gas identified using the TB method is significantly larger than the amount of gas identified using Gaussian decomposition. We also find that a large fraction of the cold gas identified using the TB method is spatially coincident with regions of recent star formation, although the converse is not true. That is only a small fraction of the regions with recent star formation are also covered by cold gas. For regions where the star formation and the cold gas overlap, we study the relationship between the star formation rate density and the cold H I column density. We find that the star formation rate density has a power-law dependence on the H I column density, but that the slope of this power law is significantly flatter than that of the canonical Kennicutt-Schmidt relation.

  13. Piliwaiwai: Problem Gambling in Hawai‘i

    PubMed Central

    2016-01-01

    Gambling is illegal in Hawai‘i, but it is accessible through technology (eg, the internet), inexpensive trips to Las Vegas, and illegal gaming such as lottery sales, internet gambling, and sports betting. Where there are opportunities to gamble, there is a probability that problem gambling exists. The social costs of gambling are estimated to be as high as $26,300,000 for Hawai‘i. Because no peer-reviewed research on this topic exists, this paper has gathered together anecdotal accounts and media reports of illegal gambling in Hawai‘i, the existence of Gamblers Anonymous meetings operating on some of the islands, and an account of workshops on problem gambling that were provided by the author on three Hawaiian Islands. Through these lenses of gambling in Hawai‘i, it is suggested that there are residents in Hawai‘i who do experience problem gambling, yet it is unknown to what extent. Nonetheless, this paper argues that research and perhaps a public health initiative are warranted. PMID:27011888

  14. Structure of mammalian respiratory complex I.

    PubMed

    Zhu, Jiapeng; Vinothkumar, Kutti R; Hirst, Judy

    2016-08-18

    Complex I (NADH:ubiquinone oxidoreductase), one of the largest membrane-bound enzymes in the cell, powers ATP synthesis in mammalian mitochondria by using the reducing potential of NADH to drive protons across the inner mitochondrial membrane. Mammalian complex I (ref. 1) contains 45 subunits, comprising 14 core subunits that house the catalytic machinery (and are conserved from bacteria to humans) and a mammalian-specific cohort of 31 supernumerary subunits. Knowledge of the structures and functions of the supernumerary subunits is fragmentary. Here we describe a 4.2-Å resolution single-particle electron cryomicroscopy structure of complex I from Bos taurus. We have located and modelled all 45 subunits, including the 31 supernumerary subunits, to provide the entire structure of the mammalian complex. Computational sorting of the particles identified different structural classes, related by subtle domain movements, which reveal conformationally dynamic regions and match biochemical descriptions of the 'active-to-de-active' enzyme transition that occurs during hypoxia. Our structures therefore provide a foundation for understanding complex I assembly and the effects of mutations that cause clinically relevant complex I dysfunctions, give insights into the structural and functional roles of the supernumerary subunits and reveal new information on the mechanism and regulation of catalysis. PMID:27509854

  15. GLOBAL H I KINEMATICS IN DWARF GALAXIES

    SciTech Connect

    Stilp, Adrienne M.; Dalcanton, Julianne J.; Warren, Steven R.; Skillman, Evan; Ott, Juergen; Koribalski, Baerbel

    2013-03-10

    H I line widths are typically interpreted as a measure of interstellar medium turbulence, which is potentially driven by star formation (SF). In an effort to better understand the possible connections between line widths and SF, we have characterized H I kinematics in a sample of nearby dwarf galaxies by co-adding line-of-sight spectra after removing the rotational velocity to produce average global H I line profiles. These ''superprofiles'' are composed of a central narrow peak ({approx}6-10 km s{sup -1}) with higher-velocity wings to either side that contain {approx}10%-15% of the total flux. The superprofiles are all very similar, indicating a universal global H I profile for dwarf galaxies. We compare characteristics of the superprofiles to various galaxy properties, such as mass and measures of SF, with the assumption that the superprofile represents a turbulent peak with energetic wings to either side. We use these quantities to derive average scale heights for the sample galaxies. When comparing to physical properties, we find that the velocity dispersion of the central peak is correlated with ({Sigma}{sub HI}). The fraction of mass and characteristic velocity of the high-velocity wings are correlated with measures of SF, consistent with the picture that SF drives surrounding H I to higher velocities. While gravitational instabilities provide too little energy, the SF in the sample galaxies does provide enough energy through supernovae, with realistic estimates of the coupling efficiency, to produce the observed superprofiles.

  16. Effective File I/O Bandwidth Benchmark

    SciTech Connect

    Rabenseifner, R.; Koniges, A.E.

    2000-02-15

    The effective I/O bandwidth benchmark (b{_}eff{_}io) covers two goals: (1) to achieve a characteristic average number for the I/O bandwidth achievable with parallel MPI-I/O applications, and (2) to get detailed information about several access patterns and buffer lengths. The benchmark examines ''first write'', ''rewrite'' and ''read'' access, strided (individual and shared pointers) and segmented collective patterns on one file per application and non-collective access to one file per process. The number of parallel accessing processes is also varied and well-formed I/O is compared with non-well formed. On systems, meeting the rule that the total memory can be written to disk in 10 minutes, the benchmark should not need more than 15 minutes for a first pass of all patterns. The benchmark is designed analogously to the effective bandwidth benchmark for message passing (b{_}eff) that characterizes the message passing capabilities of a system in a few minutes. First results of the b{_}eff{_}io benchmark are given for IBM SP and Cray T3E systems and compared with existing benchmarks based on parallel Posix-I/O.

  17. Piliwaiwai: Problem Gambling in Hawai'i.

    PubMed

    Shepherd, Robin-Marie

    2016-03-01

    Gambling is illegal in Hawai'i, but it is accessible through technology (eg, the internet), inexpensive trips to Las Vegas, and illegal gaming such as lottery sales, internet gambling, and sports betting. Where there are opportunities to gamble, there is a probability that problem gambling exists. The social costs of gambling are estimated to be as high as $26,300,000 for Hawai'i. Because no peer-reviewed research on this topic exists, this paper has gathered together anecdotal accounts and media reports of illegal gambling in Hawai'i, the existence of Gamblers Anonymous meetings operating on some of the islands, and an account of workshops on problem gambling that were provided by the author on three Hawaiian Islands. Through these lenses of gambling in Hawai'i, it is suggested that there are residents in Hawai'i who do experience problem gambling, yet it is unknown to what extent. Nonetheless, this paper argues that research and perhaps a public health initiative are warranted. PMID:27011888

  18. Structural analysis of the Actinobacillus pleuropneumoniae-RTX-toxin I (ApxI) operon.

    PubMed Central

    Jansen, R; Briaire, J; Kamp, E M; Gielkens, A L; Smits, M A

    1993-01-01

    Actinobacillus pleuropneumoniae-RTX-toxin I (ApxI), an important virulence factor, is secreted by serotypes 1, 5, 9, 10, and 11 of A. pleuropneumoniae. However, sequences homologous to the secretion genes apxIBD of the ApxI operon are present in all 12 serotypes except serotype 3. The purpose of this study was to determine and compare the structures of the ApxI operons of the 12 A. pleuropneumoniae serotypes. We focused on the nucleotide sequence comparison of the ApxI-coding genes, the structures of the ApxI operons, and the transcription of the ApxI operons. We determined the nucleotide sequences of the toxin-encoding apxICA genes of serotype 9 and found that the gene for the structural toxin, apxIA, was almost identical to the apxIA gene of serotype 1. The toxin-encoding genes of the other serotypes are also similar for the main part; nevertheless, two variants were identified, one in serotypes 1, 9, and 11 and one in serotypes 5 and 10. The two apxIA variants differ mainly within the distal 110 nucleotides. Structural analysis demonstrated that intact ApxI operons, consisting of the four contiguous genes apxICABD, are present in serotypes 1, 5, 9, 10, and 11. ApxI operons with a major deletion in the apxICA genes are present in serotypes 2, 4, 6, 7, 8, and 12. Serotype 3 does not contain ApxI operon sequences. We found that all ApxI operons are transcriptionally active despite the partial deletion of the operon in some serotypes. The implications of these data for the expression and secretion of ApxI and the other Apx-toxins, ApxII and ApxIII, as well as for the development of a subunit vaccine against A. pleuropneumoniae will be discussed. Images PMID:8359891

  19. From I-Search to iSearch 2.0

    ERIC Educational Resources Information Center

    Alvey, Tara L.; Phillips, Nathan C.; Bigelow, Emily C.; Smith, Blaine E.; Pfaff, Erin; Colt, Walt; Leander, Kevin M.; Dalton, Bridget; Ma, Jasmine Y.

    2011-01-01

    This classroom narrative proposes a process for reinventing academic research and writing in secondary schools for the 21st Century. We build on Macrorie's (1988) I-Search paper, drawing on affordances of Web 2.0 technologies and culture, to initiate the iSearch 2.0 process. iSearch 2.0 consists of four phases: 1) messing about and trying on…

  20. "I Have an iPad. Now What?" Using Mobile Devices in University Physical Education Programs

    ERIC Educational Resources Information Center

    Rosenthal, Maura B.; Eliason, Susan K.

    2015-01-01

    In response to an iPad initiative at a mid-sized New England university, all faculty, junior and senior undergraduates, and graduate students were required to have iPads by the first day of class in the fall semester of 2013. Goals of the initiative focused on preparing future teachers to use the iPad as a teaching and learning tool so they could…

  1. iPhones, iPads, and medical applications for antimicrobial stewardship.

    PubMed

    Goff, Debra A

    2012-07-01

    One of the most important antimicrobial stewardship activities of the infectious diseases pharmacist and physician is to provide education and clinical information about antimicrobials to health care professionals and patients; however, clinician training and continuing education in appropriate antimicrobial use in the United States are highly variable and nonstandardized. The iPhone, iPad, and the availability of more than 12,000 medical applications (referred to as "apps") allow stewardship programs the ability to integrate novel technology with point-of-care education. This article reviews medical apps for antimicrobial stewardship programs to use on the iPhone or iPad. PMID:22605544

  2. iSpike: a spiking neural interface for the iCub robot.

    PubMed

    Gamez, D; Fidjeland, A K; Lazdins, E

    2012-06-01

    This paper presents iSpike: a C++ library that interfaces between spiking neural network simulators and the iCub humanoid robot. It uses a biologically inspired approach to convert the robot's sensory information into spikes that are passed to the neural network simulator, and it decodes output spikes from the network into motor signals that are sent to control the robot. Applications of iSpike range from embodied models of the brain to the development of intelligent robots using biologically inspired spiking neural networks. iSpike is an open source library that is available for free download under the terms of the GPL. PMID:22617339

  3. <i>Clostridium thermocellumi> DSM 1313 transcriptional responses to redox perturbation

    SciTech Connect

    Sander, Kyle B.; Wilson, Charlotte M.; M. Rodriquez, Jr.; Klingeman, Dawn Marie; Davison, Brian H.; Brown, Steven D.; Rydzak, T.

    2015-12-12

    <i>Clostridium thermocellumi> is a promising consolidated bioprocessing candidate organism capable of directly converting lignocellulosic biomass to ethanol. Current ethanol yields, productivities, and growth inhibitions are industrial deployment impediments for commodity fuel production by this bacterium. Redox imbalance under certain conditions and in engineered strains may contribute to incomplete substrate utilization and may direct fermentation products to undesirable overflow metabolites. As a result, towards a better understanding of redox metabolism in <i>C. thermocellumi>, we established continuous growth conditions and analyzed global gene expression during addition of two stress chemicals (methyl viologen and hydrogen peroxide) which changed the fermentation redox potential.

  4. Indirect searches for dark matter with the <i>Fermi> large area telescope

    SciTech Connect

    Albert, Andrea

    2015-03-24

    There is overwhelming evidence that non-baryonic dark matter constitutes ~ 27% of the energy density of the Universe. Weakly Interacting Massive Particles (WIMPs) are promising dark matter candidates that may produce γ rays via annihilation or decay detectable by the <i>Fermi> Large Area Telescope (LAT). A detection of WIMPs would also indicate the existence of physics beyond the Standard Model. We present recent results from the two cleanest indirect WIMP searches by the <i>Fermi>-LAT Collaboration: searches for γ-ray spectral lines and γ-ray emission associated with Milky Way dwarf spheroidal satellite galaxies.

  5. Human conditions of insulin-like growth factor-I (IGF-I) deficiency

    PubMed Central

    2012-01-01

    Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions). IGF-I is a closely regulated hormone. Consequently, its logical therapeutical applications seems to be limited to restore physiological circulating levels in order to recover the clinical consequences of IGF-I deficiency, conditions where, despite continuous discrepancies, IGF-I treatment has never been related to oncogenesis. Currently the best characterized conditions of IGF-I deficiency are Laron Syndrome, in children; liver cirrhosis, in adults; aging including age-related-cardiovascular and neurological diseases; and more recently, intrauterine growth restriction. The aim of this review is to summarize the increasing list of roles of IGF-I, both in physiological and pathological conditions, underlying that its potential therapeutical options seem to be limited to those proven states of local or systemic IGF-I deficiency as a replacement treatment, rather than increasing its level upper the normal range. PMID:23148873

  6. I-Xe systematics in LL chondrites

    NASA Technical Reports Server (NTRS)

    Bernatowicz, T. J.; Podosek, F. A.; Swindle, T. D.; Honda, M.

    1988-01-01

    A stepwise heating analysis of Ar and Xe data from five neutron-irradiated whole rock LL chondrites (Soko Banja, Alta Ameen, Tuxtuac, Guidder, and Olivenza) is presented, emphasizing the complicated thermal history of ordinary chondrites. None of the present meteorites show a well-defined (Ar-40)-(Ar-39) apparent age plateau comprised of more than two release fractions. Most of the samples are found to yield well-defined high-temperature correlations between Xe-129/Xe-130 and Xe-128/Xe-130, and thus determinations of I-129/I-127 and Xe-129/Xe-130 at the time of isotopic closure for Xe. As in the case of other ordinary chondrites, the I-Xe systematics for LL chondrites correlate neither with a metamorphic grade nor with chronologies based opon other methods.

  7. Unusual patterns of I-131 contamination.

    PubMed

    Ozguven, Mehmet; Ilgan, Seyfettin; Arslan, Nuri; Karacalioglu, A Ozgur; Yuksel, Dogangun; Dundar, Sabri

    2004-05-01

    Whole body imaging with radioiodine can detect functioning metastases, which can often be effectively treated with appropriate amounts of radioiodine. Non-physiologic I-131 uptake detected on images is usually interpreted as suggesting functioning thyroid metastases. However, extra-thyroidal I-131 accumulation does not always imply thyroid cancer metastases and has been reported on many occasions, including various non-thyroidal neoplasms, and contamination by body secretions. In order to avoid unnecessary therapeutic interventions it is extremely important to properly distinguish false-positive sites of I-131 localization. Three patients with unusual radioiodine contamination patterns, either presented for the first time or rarely presented in the existing literature, were reported. Reported cases consist of contamination in hair (due to styling hair with sputum), contamination in neck (due to drooling during sleep) and, contaminated chewing gum. False positive contamination sources were clarified by careful examination of patients and further images when necessary. PMID:15233290

  8. Nuclear Concrete Materials Database Phase I Development

    SciTech Connect

    Ren, Weiju; Naus, Dan J

    2012-05-01

    The FY 2011 accomplishments in Phase I development of the Nuclear Concrete Materials Database to support the Light Water Reactor Sustainability Program are summarized. The database has been developed using the ORNL materials database infrastructure established for the Gen IV Materials Handbook to achieve cost reduction and development efficiency. In this Phase I development, the database has been successfully designed and constructed to manage documents in the Portable Document Format generated from the Structural Materials Handbook that contains nuclear concrete materials data and related information. The completion of the Phase I database has established a solid foundation for Phase II development, in which a digital database will be designed and constructed to manage nuclear concrete materials data in various digitized formats to facilitate electronic and mathematical processing for analysis, modeling, and design applications.

  9. Atmospheric methyl iodide /CH3I/

    NASA Technical Reports Server (NTRS)

    Rasmussen, R. A.; Khalil, M. A. K.; Gunawardena, R.; Hoyt, S. D.

    1982-01-01

    It is found that atmospheric concentrations of CH3I are not greater than about 3 pptv over most of the earth's surface and drop to less than half this value above the boundary layer, suggesting that the compound is not likely to play such important roles, on a global scale, as the destruction of tropospheric O3 and free radicals and the increasing of the NO2/NO ratio and hydroxyl radical densities. It is hypothesized that a large portion of the global CH3I comes from oceanic regions of high biomass productivity, where the compound may play a key role in local atmospheric chemistry. Attention is given to CH3I measurement uncertainties with regard to global distribution, sources, and sinks.

  10. [Mucopolysaccharidosis I, Hurler syndrome: a case report].

    PubMed

    Amorín, Milagros; Carlin, Andrea; Prötzel, Ana

    2012-10-01

    Mucopolysaccharidosis I (MPS I) is a rare, recessively inherited, lysosomal storage disorder caused by deficiency on the enzyme a-L-iduronidase. This defect results in accumulation of heparan and dermatan sulfate in different tissues and organs due to a deficiency in the catabolism of glycosaminoglycans. The overall incidence of MPS I is 0.99-1.99/100.000 live births. There are three clinical presentations: Hurler (severe), Hurler Scheie (mild) and Scheie (mild). We report the case of a 10-years-old male patient diagnosed with Hurler syndrome, the severe presentation, 5 years ago by enzyme a-L-iduronidase activity measurement in leukocytes; with a history of recurrent respiratory infections, umbilical hernia, corneal opacity, coarse facial features, macroglossia, hearing loss, stiffness of joints, cardiac compromise, claw hands, mental retardation and stunted growth. After enzyme replacement therapy the patient has shown improvement of visceral symptoms, but the neurological damage continuous in progress. PMID:23070190

  11. The Hitchhiker's Guide to I&T

    NASA Technical Reports Server (NTRS)

    Wright, Michael R.

    1999-01-01

    With over two dozen missions since the first in 1986, the Hitchhiker project has a reputation for providing quick-reaction, low-cost flight services for Shuttle Small Payloads Project (SSPP) customers. Despite the successes, several potential improvements in customer payload integration and test (I&T) deserve consideration. This paper presents suggestions to Hitchhiker customers on how to help make the I&T process run smoother. Included are: customer requirements and interface definition, pre-integration test and evaluation, configuration management, I&T overview and planning, problem mitigation, and organizational communication. In this era of limited flight opportunities and new ISO-based requirements, issues such as these have become more important than ever.

  12. The MHC class I genes of zebrafish

    PubMed Central

    Dirscherl, Hayley; McConnell, Sean C.; Yoder, Jeffrey A.; de Jong, Jill L. O.

    2014-01-01

    Major histocompatibility complex (MHC) molecules play a central role in the immune response and in the recognition of non-self. Found in all jawed vertebrate species, including zebrafish and other teleosts, MHC genes are considered the most polymorphic of all genes. In this review we focus on the multi-faceted diversity of zebrafish MHC class I genes, which are classified into three sequence lineages: U, Z, and L. We examine the polygenic, polymorphic, and haplotypic diversity of the zebrafish MHC class I genes, discussing known and postulated functional differences between the different class I lineages. In addition, we provide the first comprehensive nomenclature for the L lineage genes in zebrafish, encompassing at least 15 genes, and characterize their sequence properties. Finally, we discuss how recent findings have shed new light on the remarkably diverse MHC loci of this species. PMID:24631581

  13. Hospice benefits and phase I cancer trials.

    PubMed

    Byock, Ira; Miles, Steven H

    2003-02-18

    Medicare denies hospice coverage to patients with terminal illnesses who enroll as participants in phase I studies, which assess the toxicity and dosing of potential treatments for incurable diseases. Federal regulations require patients to forgo curative therapies, and they interpret phase I agents as treatment for the terminal condition for which hospice care was elected. Thus, by enrolling as a participant in a phase I trial, a patient otherwise eligible for hospice is rendered ineligible. Private insurers have similar provisions for children and adults younger than 65 years of age. Such exclusions are not defensible on ethical or clinical grounds. Policymakers, insurers, and institutional review boards all have a role in resolving this problem. PMID:12585832

  14. Initial Ares I Bending Filter Design

    NASA Technical Reports Server (NTRS)

    Jang, Jiann-Woei; Bedrossian, Nazareth; Hall, Robert; Norris, H. Lee; Hall, Charles; Jackson, Mark

    2007-01-01

    The Ares-I launch vehicle represents a challenging flex-body structural environment for control system design. Software filtering of the inertial sensor output will be required to ensure control system stability and adequate performance. This paper presents a design methodology employing numerical optimization to develop the Ares-I bending filters. The filter design methodology was based on a numerical constrained optimization approach to maximize stability margins while meeting performance requirements. The resulting bending filter designs achieved stability by adding lag to the first structural frequency and hence phase stabilizing the first Ares-I flex mode. To minimize rigid body performance impacts, a priority was placed via constraints in the optimization algorithm to minimize bandwidth decrease with the addition of the bending filters. The bending filters provided here have been demonstrated to provide a stable first stage control system in both the frequency domain and the MSFC MAVERIC time domain simulation.

  15. Hot, Massive Stars in I Zw 18

    NASA Technical Reports Server (NTRS)

    Heap, Sara R.; Lindler, D.; Malumuth, E.

    2011-01-01

    I Zw 18 is one of the most primitive blue, compact dwarf galaxies. The ionized gas in I Zw 18 has a low oxygen abundance (O approx.1/30 Osun) and nitrogen abundance (N-1/100 Nsun) (Pequignot 2008). We have obtained a far-UV spectrum of the northwest massive star cluster of I Zw 18 using Hubble's Cosmic Origins Spectrograph (COS). The spectrum is compatible with continuous star-formation over the past approx.10 Myr, and a very low metallicity, log Z/Zsun 1.7, although the stellar surface may be enhanced in carbon. Stellar wind lines are very weak, and the edge velocity of wind lines is very low (approx.250 km/s).

  16. iSIGHT-FD scalability test report.

    SciTech Connect

    Clay, Robert L.; Shneider, Max S.

    2008-07-01

    The engineering analysis community at Sandia National Laboratories uses a number of internal and commercial software codes and tools, including mesh generators, preprocessors, mesh manipulators, simulation codes, post-processors, and visualization packages. We define an analysis workflow as the execution of an ordered, logical sequence of these tools. Various forms of analysis (and in particular, methodologies that use multiple function evaluations or samples) involve executing parameterized variations of these workflows. As part of the DART project, we are evaluating various commercial workflow management systems, including iSIGHT-FD from Engineous. This report documents the results of a scalability test that was driven by DAKOTA and conducted on a parallel computer (Thunderbird). The purpose of this experiment was to examine the suitability and performance of iSIGHT-FD for large-scale, parameterized analysis workflows. As the results indicate, we found iSIGHT-FD to be suitable for this type of application.

  17. Interpretation of Galileo's Io plasma and field observations: I0, I24, and I27 flybys and close polar passes

    NASA Astrophysics Data System (ADS)

    Saur, Joachim; Neubauer, Fritz M.; Strobel, Darrell F.; Summers, Michael E.

    2002-12-01

    We interpret plasma and magnetic field observations taken during the Galileo spacecraft Io flybys I0 in December 1995, I24 in October 1999, and I27 in February 2000, and we give predictions for a generic pass over Io's northern pole with a three-dimensional, two-fluid plasma model. We show that all previous field and plasma observations by the Galileo spacecraft can be explained without the assumption of an internal magnetic field of Io in contrast to claims by [1996a, 1996b] and [1997]. We are also able to reproduce both the magnitude and the structure of the double-peak magnetic field signature of the I0 flyby. The origin of this structure can be attributed to diamagnetic and inertia currents. Observations by a polar flyby should answer Io's internal magnetic field question decisively. We also study the effect of different neutral atmosphere models on Io's electrodynamic interaction. Our analysis suggests that Io's atmosphere is longitudinally asymmetric with the scale height on the upstream side smaller than on the downstream side due to the drag force of the flowing plasma on Io's atmosphere. We also show how the Hall effect in Io's ionosphere generates rotated Alfvén wings. In addition, the high-energy electrons observed by [1996, 1999] and [1999] might play an important role for the formation of Io's downstream wake.

  18. Ares I-X Flight Test Philosophy

    NASA Technical Reports Server (NTRS)

    Davis, S. R.; Tuma, M. L.; Heitzman, K.

    2007-01-01

    In response to the Vision for Space Exploration, the National Aeronautics and Space Administration (NASA) has defined a new space exploration architecture to return humans to the Moon and prepare for human exploration of Mars. One of the first new developments will be the Ares I Crew Launch Vehicle (CLV), which will carry the Orion Crew Exploration Vehicle (CEV), into Low Earth Orbit (LEO) to support International Space Station (ISS) missions and, later, support lunar missions. As part of Ares I development, NASA will perform a series of Ares I flight tests. The tests will provide data that will inform the engineering and design process and verify the flight hardware and software. The data gained from the flight tests will be used to certify the new Ares/Orion vehicle for human space flight. The primary objectives of this first flight test (Ares I-X) are the following: Demonstrate control of a dynamically similar integrated Ares CLV/Orion CEV using Ares CLV ascent control algorithms; Perform an in-flight separation/staging event between an Ares I-similar First Stage and a representative Upper Stage; Demonstrate assembly and recovery of a new Ares CLV-like First Stage element at Kennedy Space Center (KSC); Demonstrate First Stage separation sequencing, and quantify First Stage atmospheric entry dynamics and parachute performance; and Characterize the magnitude of the integrated vehicle roll torque throughout the First Stage (powered) flight. This paper will provide an overview of the Ares I-X flight test process and details of the individual flight tests.

  19. Saturn I (SA-1) on Launch Pad

    NASA Technical Reports Server (NTRS)

    1961-01-01

    On October 27, 1961, the Marshall Space Flight Center and the Nation marked a high point in the 3-year-old Saturn development program when the first Saturn vehicle, SA-1, flew a flawless 215-mile ballistic trajectory from Cape Canaveral, Florida. SA-1 is pictured here on the launch pad ready for lift off. Developed at the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun, SA-1 incorporated a Saturn I, Block I engine. The typical height of a Block I vehicle was approximately 163 feet and had only one live stage. It consisted of eight tanks, each 70 inches in diameter, clustered around a central tank, 105 inches in diameter. Four of the external tanks were fuel tanks for the RP-1 (kerosene) fuel. The other four, spaced alternately with the fuel tanks, were liquid oxygen tanks, as was the large center tank. All fuel tanks and liquid oxygen tanks drained at the same rates respectively. The thrust for the stage came from eight H-1 engines, each producing a thrust of 165,000 pounds, for a total thrust of over 1,300,000 pounds. The engines were arranged in a double pattern. Four engines, located inboard, were fixed in a square pattern around the stage axis and canted outward slightly, while the remaining four engines were located outboard in a larger square pattern offset 40 degrees from the inner pattern. Unlike the inner engines, each outer engine was gimbaled. That is, each could be swung through an arc. They were gimbaled as a means of steering the rocket, by letting the instrumentation of the rocket correct any deviations of its powered trajectory. The block I required engine gimabling as the only method of guiding and stabilizing the rocket through the lower atmosphere. The upper stages of the Block I rocket reflected the three-stage configuration of the Saturn I vehicle.

  20. The dwarf spheroidal galaxy Andromeda I

    SciTech Connect

    Mould, J.; Kristian, J. Mount Wilson and Las Campanas Observatories, Pasadena, CA )

    1990-05-01

    Images of Andromeda I in the visual and near-infrared show a giant branch characteristic of galactic globular clusters of intermediate metallicity. The distance of the galaxy is estimated from the tip of the giant branch to be 790 + or - 60 kpc. The physical dimensions and luminosity are similar to those of the dwarf spheroidal in Sculptor. There is no evidence for an intermediate age population in Andromeda I, and appropriate upper limits are specified. There is marginal evidence for a color gradient in the galaxy, a phenomenon not previously noted in a dwarf spheroidal. 21 refs.

  1. COS Pipeline Calibration at STScI

    NASA Astrophysics Data System (ADS)

    Hodge, Philip E.

    The Cosmic Origins Spectrograph (COS) will be installed in the Hubble Space Telescope (HST) in 2004. As with other HST instruments, COS data will be routinely calibrated at the Space Telescope Science Institute. This paper describes plans for developing the calibration program CALCOS. Previous HST calibration pipeline routines were written in Fortran, SPP, or C, using IRAF image I/O and CFITSIO for tables. CALCOS will be written in Python with C extension modules, and it will use PyFITS for image and table I/O.

  2. I-Xe ages of enstatite chondrites

    NASA Astrophysics Data System (ADS)

    Hopp, Jens; Trieloff, Mario; Ott, Ulrich

    2016-02-01

    In order to elucidate the early thermal history of enstatite chondrite parent bodies we determined 129I-129Xe whole rock ages of enstatite chondrites (5 EH, 2 EL, one EH impact melt) relative to the Shallowater reference meteorite (4562.3 ± 0.4 Ma, all errors are 1σ). I-Xe ages of both EL6 chondrites (LON 94100: -4.38 ± 0.60 Ma and Neuschwanstein: -3.87 ± 0.73 Ma - negative sign indicates ages younger than Shallowater) agree well with data of other EL6 chondrites. LON 94100 displayed a second isochron at lower temperatures equivalent to a younger age of -5.25 ± 1.17 Ma, perhaps reflecting different retention temperatures of respective carrier phases during sequential cooling. The enstatite chondrites Abee (EH4), Indarch (EH4), EET 96135 (EH4/5) and St. Marks (EH5) encompass a I-Xe age range of +0.57 ± 1.05 Ma (EET 96135 #1) to -0.45 ± 0.72 Ma (Abee), again in agreement with previously reported ages of EH chondrites. Only the age of St. Marks differs strongly from previously reported younger ages, now being more in accordance with other members of the EH clan. The EH3 chondrite Sahara 97096 showed the youngest I-Xe age of -7.87 ± 0.46 Ma distinctly younger than other I-Xe ages of EH chondrites, including other EH3s. Due to the apparent high retention temperature of the I-Xe system in enstatite (estimated >800 °C) this young age implies a later resetting of the I-Xe system by a severe thermal, likely impact-induced, event. The EH impact melt LAP 02225 records a similarly young thermal event. Though no isochron relationship could be established, the data fall within an apparent I-Xe age range of +5 to +15 Ma, similar to Sahara 97096. Overall, EH chondrite parent body experienced a thermal history determined by a complex interplay between impact disturbances and parent body metamorphism.

  3. Timeline: iPSCs-The First Decade.

    PubMed

    Chari, Sheila; Mao, Steve

    2016-02-01

    Research into induced pluripotent stem cells (iPSCs) has expanded at a remarkable pace in the decade since Shinya Yamanaka and Kazutoshi Takahashi first reported their groundbreaking discovery in 2006. This Timeline highlights the key events in the development of this field, including basic insights into the production of iPSCs and how they have been applied to improve our understanding and treatment of human disease. To view this Timeline, open or download the PDF. You can also listen to the associated interview with Debbie Sweet, Editor of Cell Stem Cell, and Elena Porro, Editor of Cell. PAPERCLIP. PMID:26849306

  4. Bioconversion of rebaudioside I from rebaudioside A.

    PubMed

    Prakash, Indra; Bunders, Cynthia; Devkota, Krishna P; Charan, Romila D; Ramirez, Catherine; Snyder, Tara M; Priedemann, Christopher; Markosyan, Avetik; Jarrin, Cyrille; Halle, Robert Ter

    2014-01-01

    To supply the increasing demand of natural high potency sweeteners to reduce the calories in food and beverages, we have looked to steviol glycosides. In this work we report the bioconversion of rebaudioside A to rebaudioside I using a glucosyltransferase enzyme. This bioconversion reaction adds one sugar unit with a 1→3 linkage. We utilized 1D and 2D NMR spectroscopy (1H, 13C, COSY, HSQC-DEPT, HMBC, 1D TOCSY and NOESY) and mass spectral data to fully characterize rebaudioside I. PMID:25353385

  5. Autoindexing diffraction images with iMosflm

    SciTech Connect

    Powell, Harold R.; Johnson, Owen; Leslie, Andrew G. W.

    2013-07-01

    The principles of one-dimensional FFT-based autoindexing of diffraction images are described together with practical issues that may arise. A procedure for indexing multiple lattices as implemented in iMosflm is presented. An overview of autoindexing diffraction images based on one-@@dimensional fast Fourier transforms is presented. The implementation of the algorithm in the Mosflm/iMosflm program suite is described with a discussion of practical issues that may arise and ways of assessing the success or failure of the procedure. Recent developments allow indexing of images that show multiple lattices, and several examples demonstrate the success of this approach in real cases.

  6. Pituitary and hypothalamic insulin-like growth factor-I (IGF-I) and IGF-I receptor expression in food-deprived rats.

    PubMed

    Olchovsky, D; Song, J; Gelato, M C; Sherwood, J; Spatola, E; Bruno, J F; Berelowitz, M

    1993-06-01

    The present study was designed to evaluate a possible role for the insulin-like growth factor-I (IGF-I) system in mediating the suppression of growth hormone (GH) secretion observed in food-deprived rats by measuring IGF-I mRNA, receptor concentration and receptor mRNA in neuroendocrine tissues (hypothalamus and pituitary). Rats were deprived of food (food-deprived) for 72 h or had free access to food (fed). Tissues were processed for measurement of steady-state levels of: (a) IGF-I and IGF-I receptor mRNA (by solution hybridization/RNase protection assay); (b) IGF-I in serum and tissue extracts (by RIA) and (c) IGF-I displaceable [125I]IGF-I binding to plasma membrane preparations. Food deprivation resulted in decreased serum and liver levels of IGF-I. Kidney IGF-I mRNA levels were reduced 80% in food-deprived rats with a concomitant increase in IGF-I receptor concentration and mRNA levels. Refeeding of food-deprived rats fully normalized these perturbations. Pituitary IGF-I content was reduced 50% in food-deprived rats while IGF-I mRNA levels were unaffected. A modest increase was seen in pituitary IGF-I receptor concentration; however, IGF-I receptor mRNA levels were not changed. Hypothalamic IGF-I mRNA content was reduced in 72 h food-deprived rats while IGF-I receptor binding capacity and mRNA were unaffected. In conclusion, IGF-I mRNA levels are decreased in liver, kidney and hypothalamus together with a reduction in plasma IGF-I in food-deprived rats but is unaffected in anterior pituitary. IGF-I receptor gene expression and binding capacity are coordinately regulated in kidney and hypothalamus, but not in the pituitary.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8349028

  7. 26 CFR 1.642(i)-2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (i)-1(c)(1). (d) Care and maintenance. For purposes of section 642(i) and this section, the term care... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Definitions. 1.642(i)-2 Section 1.642(i)-2...) INCOME TAXES (CONTINUED) Estates, Trusts, and Beneficiaries § 1.642(i)-2 Definitions. (a)...

  8. 5 CFR 894.203 - If I have a self plus one enrollment, when may I change which family member I want to cover or...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., when may I change which family member I want to cover or change to self only? 894.203 Section 894.203... plus one enrollment, when may I change which family member I want to cover or change to self only? You may change your covered family member under a self plus one enrollment or change to self only...

  9. 5 CFR 894.203 - If I have a self plus one enrollment, when may I change which family member I want to cover or...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., when may I change which family member I want to cover or change to self only? 894.203 Section 894.203... plus one enrollment, when may I change which family member I want to cover or change to self only? You may change your covered family member under a self plus one enrollment or change to self only...

  10. 5 CFR 894.203 - If I have a self plus one enrollment, when may I change which family member I want to cover or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., when may I change which family member I want to cover or change to self only? 894.203 Section 894.203... plus one enrollment, when may I change which family member I want to cover or change to self only? You may change your covered family member under a self plus one enrollment or change to self only...

  11. 5 CFR 894.203 - If I have a self plus one enrollment, when may I change which family member I want to cover or...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., when may I change which family member I want to cover or change to self only? 894.203 Section 894.203... plus one enrollment, when may I change which family member I want to cover or change to self only? You may change your covered family member under a self plus one enrollment or change to self only...

  12. 5 CFR 894.203 - If I have a self plus one enrollment, when may I change which family member I want to cover or...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., when may I change which family member I want to cover or change to self only? 894.203 Section 894.203... plus one enrollment, when may I change which family member I want to cover or change to self only? You may change your covered family member under a self plus one enrollment or change to self only...

  13. The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection

    PubMed Central

    Ramanathan, Anand; Devarkar, Swapnil C.; Jiang, Fuguo; Miller, Matthew T.; Khan, Abdul G.; Marcotrigiano, Joseph; Patel, Smita S.

    2016-01-01

    RIG-I (Retinoic Acid Inducible Gene-I) is a cytosolic innate immune receptor that detects atypical features in viral RNAs as foreign to initiate a Type I interferon signaling response. RIG-I is present in an autoinhibited state in the cytoplasm and activated by blunt-ended double-stranded (ds)RNAs carrying a 5′ triphosphate (ppp) moiety. These features found in many pathogenic RNAs are absent in cellular RNAs due to post-transcriptional modifications of RNA ends. Although RIG-I is structurally well characterized, the mechanistic basis for RIG-I's remarkable ability to discriminate between cellular and pathogenic RNAs is not completely understood. We show that RIG-I's selectivity for blunt-ended 5′-ppp dsRNAs is ≈3000 times higher than non-blunt ended dsRNAs commonly found in cellular RNAs. Discrimination occurs at multiple stages and signaling RNAs have high affinity and ATPase turnover rate and thus a high katpase/Kd. We show that RIG-I uses its autoinhibitory CARD2-Hel2i (second CARD-helicase insertion domain) interface as a barrier to select against non-blunt ended dsRNAs. Accordingly, deletion of CARDs or point mutations in the CARD2-Hel2i interface decreases the selectivity from ≈3000 to 150 and 750, respectively. We propose that the CARD2-Hel2i interface is a ‘gate’ that prevents cellular RNAs from generating productive complexes that can signal. PMID:26612866

  14. How I Love My 80 Percenters

    NASA Technical Reports Server (NTRS)

    Maturo, Anthony J.

    2002-01-01

    Don't ever take your support staff for granted. By support staff, I mean the people in personnel, logistics, and finance; the ones who can make things happen with a phone call or a signature, or by the same token frustrate you to no end by their inaction; these are people you must depend on. I've spent a lot of time thinking about how to cultivate relationships with my support staff that work to the advantage of both of us. The most important thing that have learned working with people, any people--and I will tell you how I learned this in a minute--is there are some folks you just can't motivate, so forget it, don't try; others you certainly can with a little psychology and some effort; and the best of the bunch, what I call the 80 percenters, you don't need to motivate because they're already on the team and performing beautifully. The ones you can't change are rocks. Face up to it, and just kick them out of your way. I have a reputation with the people who don't want to perform or be part of the team. They don't come near me. If someone's a rock, I pick up on it right away, and I will walk around him or her to find someone better. The ones who can be motivated I take time to nurture. I consider them my projects. A lot of times these wannabes are people who want to help but don't know how. Listen, you can work with them. Lots of people in organizations have the mindset that all that matters are the regulations. God forbid if you ever work outside those regulations. They've got one foot on that regulation and they're holding it tight like a baby holds a blanket. What you're looking for is that first sign that their minds are opening. Usually you hear it in their vocabulary. What used to sound like "We can't do that ... the regulations won't allow it ... we have never done this before," well, suddenly that changes to "We have options ... let's take a look at the options ... let me research this and get back to you." The 80 percenters you want to nurture too, but

  15. Comparative genomic analysis of nine <i>Sphingobium> strains: Insights into their evolution and hexachlorocyclohexane (HCH) degradation pathways

    SciTech Connect

    Verma, Helianthous; Kumar, Roshan; Oldach, Phoebe; Sangwan, Naseer; Khurana, Jitendra P.; Gilbert, Jack A.; Lal, Rup

    2014-11-23

    Background: <i>Sphingobium> spp. are efficient degraders of a wide range of chlorinated and aromatic hydrocarbons. In particular, strains which harbour the <i>lin> pathway genes mediating the degradation of hexachlorocyclohexane (HCH) isomers are of interest due to the widespread persistence of this contaminant. Here, we examined the evolution and diversification of the <i>lin> pathway under the selective pressure of HCH, by comparing the draft genomes of six newly-sequenced <i>Sphingobium> spp. (strains LL03, DS20, IP26, HDIPO4, P25 and RL3) isolated from HCH dumpsites, with three existing genomes (<i>S. indicumi> B90A, <i>S. japonicumi> UT26S and <i>Sphingobium> sp. SYK6). Results: Efficient HCH degraders phylogenetically clustered in a closely related group comprising of UT26S, B90A, HDIPO4 and IP26, where HDIPO4 and IP26 were classified as subspecies with ANI value >98%. Less than 10% of the total gene content was shared among all nine strains, but among the eight HCH-associated strains, that is all except SYK6, the shared gene content jumped to nearly 25%. Genes associated with nitrogen stress response and two-component systems were found to be enriched. The strains also housed many xenobiotic degradation pathways other than HCH, despite the absence of these xenobiotics from isolation sources. In addition, these strains, although non-motile, but posses flagellar assembly genes. While strains HDIPO4 and IP26 contained the complete set of <i>lin> genes, DS20 was entirely devoid of <i>lin> genes (except <i>linKLMN>) whereas, LL03, P25 and RL3 were identified as <i>lin> deficient strains, as they housed incomplete <i>lin> pathways. Further, in HDIPO4, <i>linA> was found as a hybrid of two natural variants i.e., <i>linA1i> and <i>linA2i> known for their different enantioselectivity. In conclusion, the bacteria isolated from HCH dumpsites provide a natural testing ground to study variations in the <i>lin> system and their

  16. 30 CFR 280.10 - What must I do before I may conduct prospecting activities?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What must I do before I may conduct prospecting activities? 280.10 Section 280.10 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND... prospecting activities, including deep stratigraphic tests, for hard minerals. If you conduct both...

  17. 30 CFR 580.10 - What must I do before I may conduct prospecting activities?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What must I do before I may conduct prospecting activities? 580.10 Section 580.10 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE... activities? You must have a BOEM-approved permit to conduct G&G prospecting activities, including...

  18. 30 CFR 580.10 - What must I do before I may conduct prospecting activities?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What must I do before I may conduct prospecting activities? 580.10 Section 580.10 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE... activities? You must have a BOEM-approved permit to conduct G&G prospecting activities, including...

  19. 30 CFR 580.10 - What must I do before I may conduct prospecting activities?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What must I do before I may conduct prospecting activities? 580.10 Section 580.10 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE... activities? You must have a BOEM-approved permit to conduct G&G prospecting activities, including...

  20. 30 CFR 1204.212 - What if I took relief for which I was ineligible?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false What if I took relief for which I was ineligible? 1204.212 Section 1204.212 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE ALTERNATIVES FOR MARGINAL PROPERTIES Accounting and...

  1. 30 CFR 1204.212 - What if I took relief for which I was ineligible?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false What if I took relief for which I was ineligible? 1204.212 Section 1204.212 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE ALTERNATIVES FOR MARGINAL PROPERTIES Accounting and...

  2. 30 CFR 1204.212 - What if I took relief for which I was ineligible?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false What if I took relief for which I was ineligible? 1204.212 Section 1204.212 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE ALTERNATIVES FOR MARGINAL PROPERTIES Accounting and...

  3. 30 CFR 585.831 - What incidents must I report, and when must I report them?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What incidents must I report, and when must I report them? 585.831 Section 585.831 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Environmental and Safety...

  4. 30 CFR 285.831 - What incidents must I report, and when must I report them?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What incidents must I report, and when must I report them? 285.831 Section 285.831 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Environmental and Safety...

  5. 30 CFR 585.831 - What incidents must I report, and when must I report them?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What incidents must I report, and when must I report them? 585.831 Section 585.831 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Environmental and Safety...

  6. 30 CFR 285.831 - What incidents must I report, and when must I report them?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What incidents must I report, and when must I report them? 285.831 Section 285.831 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL...

  7. 30 CFR 585.831 - What incidents must I report, and when must I report them?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What incidents must I report, and when must I report them? 585.831 Section 585.831 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Environmental and Safety...

  8. 30 CFR 57.22401 - Underground retorts (I-A and I-B mines).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Underground retorts (I-A and I-B mines). 57... METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Underground Retorts §...

  9. 30 CFR 285.910 - What must I do when I remove my facility?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I do when I remove my facility? 285.910 Section 285.910 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF...

  10. 43 CFR 2807.12 - If I hold a grant, for what am I liable?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false If I hold a grant, for what am I liable? 2807.12 Section 2807.12 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) RIGHTS-OF-WAY UNDER THE FEDERAL LAND POLICY MANAGEMENT ACT...

  11. The Contrast Between Title I and Non-Title I Schools.

    ERIC Educational Resources Information Center

    Fortune, Jim C.; Hutchinson, Thomas E.

    The problem addressed in this paper is to compare the schools identified as participating in Title I, 1965 Elementary Secondary Education Act programs, with those identified as not participating in Title I, with regard to percentage of pupils on welfare, number of target group pupils, percentage of pupils reading below grade level, percentage of…

  12. σ54-dependent regulome in <i>Desulfovibrio vulgarisi> Hildenborough

    SciTech Connect

    Kazakov, Alexey E.; Rajeev, Lara; Chen, Amy; Luning, Eric G.; Dubchak, Inna; Mukhopadhyay, Aindrila; Novichkov, Pavel S.

    2015-11-10

    The σ54 subunit controls a unique class of promoters in bacteria. Such promoters, without exception, require enhancer binding proteins (EBPs) for transcription initiation. <i>Desulfovibrio vulgarisi> Hildenborough, a model bacterium for sulfate reduction studies, has a high number of EBPs, more than most sequenced bacteria. Finally, the cellular processes regulated by many of these EBPs remain unknown.

  13. TITLE I IN OHIO, FIRST ANNUAL EVALUATION OF TITLE I--FISCAL YEAR 1966.

    ERIC Educational Resources Information Center

    WORKING, RUSSELL A.; YOUNG, EILEEN

    THE NATURE AND IMPACT OF OHIO'S TITLE I COMPENSATORY EDUCATION PROJECTS ARE EVALUATED IN THIS REPORT. PROJECT PARTICIPANTS WERE CHARACTERIZED BY LOW ACADEMIC ACHIEVEMENT, WITHDRAWAL AND FEELINGS OF REJECTION, ABSENTEEISM, AND IRRESPONSIBILITY. ONLY 50 PERCENT OF THEM HAD PLANS FOR CONTINUING THEIR EDUCATION WHILE 70 PERCENT OF NONTITLE I PUPILS…

  14. 5 CFR 875.210 - What happens if I become ineligible after I submit an application?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false What happens if I become ineligible after I submit an application? 875.210 Section 875.210 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL LONG TERM CARE INSURANCE...

  15. Genome assemblies for 11 <i>Yersinia pestisi> strains isolated in the Caucasus region

    SciTech Connect

    Zhgenti, Ekaterine; Johnson, Shannon L.; Davenport, Karen W.; Chanturia, Gvantsa; Daligault, Hajnalka E.; Chain, Patrick S.; Nikolich, Mikeljon P.

    2015-09-17

    <i>Yersinia pestisi>, the causative agent of plague, is endemic to the Caucasus region but few reference strain genome sequences from that region are available. We present the improved draft or finished assembled genomes from 11 strains isolated in the nation of Georgia and surrounding countries.

  16. 21 CFR 822.5 - How will I know if I must conduct postmarket surveillance?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... surveillance? 822.5 Section 822.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Notification § 822.5 How will I know if I must conduct postmarket surveillance? We will send you a letter (the postmarket surveillance order)...

  17. 21 CFR 822.5 - How will I know if I must conduct postmarket surveillance?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... surveillance? 822.5 Section 822.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Notification § 822.5 How will I know if I must conduct postmarket surveillance? We will send you a letter (the postmarket surveillance order)...

  18. 21 CFR 822.5 - How will I know if I must conduct postmarket surveillance?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... surveillance? 822.5 Section 822.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Notification § 822.5 How will I know if I must conduct postmarket surveillance? We will send you a letter (the postmarket surveillance order)...

  19. 8 CFR 204.308 - Where to file Form I-800A or Form I-800.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... provisionally approved under 8 CFR 204.313(g) and the petitioner has either adopted or obtained custody of the... eligible both under 8 CFR 204.309(b)(4) for approval of a Form I-800 and under 8 CFR part 245 for... IMMIGRANT PETITIONS Intercountry Adoption of a Convention Adoptee § 204.308 Where to file Form I-800A...

  20. 7 CFR 170.7 - Can I apply if I am not recruited?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) MISCELLANEOUS MARKETING PRACTICES UNDER THE AGRICULTURAL MARKETING ACT OF 1946 USDA FARMERS MARKET § 170.7 Can I apply if I am...

  1. 40 CFR 1045.210 - May I get preliminary approval before I complete my application?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false May I get preliminary approval before I complete my application? 1045.210 Section 1045.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION...

  2. 40 CFR 1048.210 - May I get preliminary approval before I complete my application?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false May I get preliminary approval before I complete my application? 1048.210 Section 1048.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, LARGE NONROAD...

  3. 40 CFR 370.30 - What information must I provide and what format must I use?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 27 2010-07-01 2010-07-01 false What information must I provide and what format must I use? 370.30 Section 370.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS HAZARDOUS CHEMICAL REPORTING: COMMUNITY RIGHT-TO-KNOW...

  4. 40 CFR 370.40 - What information must I provide and what format must I use?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 27 2010-07-01 2010-07-01 false What information must I provide and what format must I use? 370.40 Section 370.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS HAZARDOUS CHEMICAL REPORTING: COMMUNITY RIGHT-TO-KNOW...

  5. 27 CFR 73.32 - May I electronically sign forms I submit electronically to TTB?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURES AND PRACTICES ELECTRONIC SIGNATURES; ELECTRONIC SUBMISSION OF FORMS Electronic Filing of Documents with TTB § 73.32 May I electronically sign forms I submit electronically to TTB? You may electronically sign the electronic form...

  6. 12 CFR 550.200 - Must I review a prospective account before I accept it?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... accept it? 550.200 Section 550.200 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE... § 550.200 Must I review a prospective account before I accept it? Before accepting a prospective fiduciary account, you must review it to determine whether you can properly administer the account....

  7. 12 CFR 550.200 - Must I review a prospective account before I accept it?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... accept it? 550.200 Section 550.200 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE... § 550.200 Must I review a prospective account before I accept it? Before accepting a prospective fiduciary account, you must review it to determine whether you can properly administer the account....

  8. 12 CFR 150.200 - Must I review a prospective account before I accept it?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... accept it? 150.200 Section 150.200 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE... Account § 150.200 Must I review a prospective account before I accept it? Before accepting a prospective fiduciary account, you must review it to determine whether you can properly administer the account....

  9. 12 CFR 550.200 - Must I review a prospective account before I accept it?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... accept it? 550.200 Section 550.200 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE... § 550.200 Must I review a prospective account before I accept it? Before accepting a prospective fiduciary account, you must review it to determine whether you can properly administer the account....

  10. 12 CFR 550.200 - Must I review a prospective account before I accept it?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... accept it? 550.200 Section 550.200 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE... § 550.200 Must I review a prospective account before I accept it? Before accepting a prospective fiduciary account, you must review it to determine whether you can properly administer the account....

  11. 12 CFR 150.200 - Must I review a prospective account before I accept it?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... accept it? 150.200 Section 150.200 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE... Account § 150.200 Must I review a prospective account before I accept it? Before accepting a prospective fiduciary account, you must review it to determine whether you can properly administer the account....

  12. 12 CFR 150.200 - Must I review a prospective account before I accept it?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... accept it? 150.200 Section 150.200 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE... Account § 150.200 Must I review a prospective account before I accept it? Before accepting a prospective fiduciary account, you must review it to determine whether you can properly administer the account....

  13. 40 CFR 63.5714 - How do I demonstrate compliance if I use filled resins?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true How do I demonstrate compliance if I use filled resins? 63.5714 Section 63.5714 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards...

  14. Infertility resulting from transgenic I-PpoI male Anopheles gambiae in large cage trials

    PubMed Central

    Klein, T A; Windbichler, N; Deredec, A; Burt, A; Benedict, M Q

    2012-01-01

    Objectives Anopheles gambiae is the primary vector of malaria in sub-Saharan Africa and is a potential target of genetic control programs. We determined the capacity of male A. gambiae created by germline transformation to introduce infertility into stable age-distribution populations. We also determined effects of the transgenes on life history. Methods Stable age-distribution populations of A. gambiae mosquitoes were established in large indoor cages. Male mosquitoes carrying an I-PpoI homing endonuclease gene were introduced at ×5 and ×10 release rates where they competed with target male mosquitoes for matings. Similar trials were conducted in small cages with an additional ×1 release level. Results Infertility was successfully introduced into all target populations. In supporting experiments, complete female infertility was observed in all strains and species of the A. gambiae complex to which transgenic males were mated. Life history experiments demonstrated that reductions in I-PpoI male vigor exist in the form of reduced adult male emergence, longevity and competitiveness. Discussion A. gambiae I-PpoI males are capable of introducing high levels of infertility in target populations in indoor cage trials. This was accomplished despite losses of vigor resulting from the HEG transgene. These results motivate further trials of sexually I-PpoI A. gambiae in outdoor cage and field trials. PMID:22595271

  15. 49 CFR 371.109 - Must I inform individual shippers which motor carriers I use?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Must I inform individual shippers which motor... individual shippers which motor carriers I use? (a) You must provide to each potential individual shipper who... must provide to each potential individual shipper who contacts you a statement indicating that you...

  16. 43 CFR 2807.12 - If I hold a grant, for what am I liable?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false If I hold a grant, for what am I liable? 2807.12 Section 2807.12 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) RIGHTS-OF-WAY UNDER THE FEDERAL LAND POLICY MANAGEMENT ACT...

  17. 43 CFR 2807.12 - If I hold a grant, for what am I liable?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false If I hold a grant, for what am I liable? 2807.12 Section 2807.12 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) RIGHTS-OF-WAY UNDER THE FEDERAL LAND POLICY MANAGEMENT ACT...

  18. 40 CFR 267.1106 - What do I do if I detect a release?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false What do I do if I detect a release? 267.1106 Section 267.1106 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... building, to remove any leakage from the secondary collection system, and to establish a schedule...

  19. 40 CFR 267.1106 - What do I do if I detect a release?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false What do I do if I detect a release? 267.1106 Section 267.1106 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... building, to remove any leakage from the secondary collection system, and to establish a schedule...

  20. 40 CFR 267.1106 - What do I do if I detect a release?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false What do I do if I detect a release? 267.1106 Section 267.1106 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... building, to remove any leakage from the secondary collection system, and to establish a schedule...