The degeneracy problem in non-canonical inflation
Easson, Damien A.; Powell, Brian A. E-mail: brian.powell007@gmail.com
2013-03-01
While attempting to connect inflationary theories to observational physics, a potential difficulty is the degeneracy problem: a single set of observables maps to a range of different inflaton potentials. Two important classes of models affected by the degeneracy problem are canonical and non-canonical models, the latter marked by the presence of a non-standard kinetic term that generates observables beyond the scalar and tensor two-point functions on CMB scales. The degeneracy problem is manifest when these distinguishing observables go undetected. We quantify the size of the resulting degeneracy in this case by studying the most well-motivated non-canonical theory having Dirac-Born-Infeld Lagrangian. Beyond the scalar and tensor two-point functions on CMB scales, we then consider the possible detection of equilateral non-Gaussianity at Planck-precision and a measurement of primordial gravitational waves from prospective space-based laser interferometers. The former detection breaks the degeneracy with canonical inflation but results in poor reconstruction prospects, while the latter measurement enables a determination of n{sub T} which, while not breaking the degeneracy, can be shown to greatly improve the non-canonical reconstruction.
A Problem-Centered Approach to Canonical Matrix Forms
ERIC Educational Resources Information Center
Sylvestre, Jeremy
2014-01-01
This article outlines a problem-centered approach to the topic of canonical matrix forms in a second linear algebra course. In this approach, abstract theory, including such topics as eigenvalues, generalized eigenspaces, invariant subspaces, independent subspaces, nilpotency, and cyclic spaces, is developed in response to the patterns discovered…
New ways of investigating the canonical coin toss acceleration problem
NASA Astrophysics Data System (ADS)
Wittmann, Michael C.; Hawkins, Jeffrey M.
2013-01-01
Asking students about the acceleration of a tossed object is a well-studied problem in physics education research. Students frequently respond using reasoning that describes the velocity of the object, in particular that acceleration is zero at the top. We created new versions of the canonical multiple-choice Force and Motion Conceptual Evaluation coin-toss questions to investigate what other reasoning students might use. Some students were asked "is the acceleration zero at the top?" Other students were told "the acceleration is not zero" and asked to explain. A third group answered the original multiple-choice version of the question. Our results suggest that some students give answers that they can explain are incorrect. We also find that some students' responses about the acceleration at the turnaround point are affected by question format.
ERIC Educational Resources Information Center
ten Berge, Jos M. F.
1988-01-01
A summary and a unified treatment of fully general computational solutions for two criteria for transforming two or more matrices to maximal agreement are provided. The two criteria--Maxdiff and Maxbet--have applications in the rotation of factor loading or configuration matrices to maximal agreement and the canonical correlation problem. (SLD)
Ji, Un Cig; Obata, Nobuaki
2010-12-15
The implementation problem for the canonical commutation relation is reduced to a system of differential equations for Fock space operators containing new type of derivatives. We solve these differential equations systematically by means of quantum white noise calculus, and obtain the solution to the implementation problem.
Radial oscillation of a gas bubble in a fluid as a problem in canonical perturbation theory
NASA Astrophysics Data System (ADS)
Stephens, James
2005-11-01
The oscillation of a gas bubble is in a fluid is of interest in many areas of physics and technology. Lord Rayleigh treated the pressure developed in the collapse of cavitation bubbles and developed an expression for the collapse period. Minnaert developed a harmonic oscillator approximation to bubble oscillation in his study of the sound produced by running water. Oscillating bubbles are important to oceanographers studying the sound spectrum produced by water waves, geophysicists employing air guns as acoustic probes, mechanical engineers concerned with erosion of turbine blades, and military engineers concerned with the acoustic signatures developed by the propeller screws of ships and submarines. For the oceanographer, Minnaert's approximation is useful, for the latter two examples, Lord Rayleigh's analysis is appropriate. On the one hand, a bubble can be treated as a harmonic oscillator in the small amplitude regime, whereas even in the relatively moderate pressure regime characteristic of air guns the oscillation is strongly nonlinear and amplitude dependent. Is it possible to develop an analytic approximation that affords insight into the behavior of a bubble beyond the harmonic approximation of Minnaert? In this spirit, the free radial oscillation of a gas bubble in a fluid is treated as a problem in canonical perturbation theory. Several orders of the expansion are determined in order to explore the dependence of the oscillation frequency with bubble amplitude. The expansion to second order is inverted to express the time dependence of the oscillation.
Radial oscillation of a gas bubble in a fluid as a problem in canonical perturbation theory
NASA Astrophysics Data System (ADS)
Stephens, James
2006-11-01
The oscillation of a gas bubble is in a fluid is of interest in many areas of physics and technology. Lord Rayleigh treated the pressure developed in the collapse of cavitation bubbles and developed an expression for the collapse period. Minnaert developed a harmonic oscillator approximation to bubble oscillation in his study of the sound produced by running water. Besides recent interest in bubble oscillation in connection to sonoluminescence, an understanding of oscillating bubbles is of important to oceanographers studying the sound spectrum produced by water waves, geophysicists employing air guns as acoustic probes, mechanical engineers concerned with erosion of turbine blades, and military engineers concerned with the acoustic signatures developed by the propeller screws of ships and submarines. For the oceanographer, Minnaert's approximation is useful, for the latter two examples, Lord Rayleigh's analysis is appropriate. For the case of the airgun, a period of twice Rayleigh's period for the ``total collapse'' of the cavitation bubble is often cited as a good approximation for the period of an air bubble ejected from an air gun port, typically at ˜2000 psi), however for the geophysical example, numerical integration is employed from the outset to determine the dynamics of the bubble and the emitted acoustic energy. On the one hand, a bubble can be treated as a harmonic oscillator in the small amplitude regime, whereas even in the relatively moderate pressure regime characteristic of air guns the oscillation is strongly nonlinear and amplitude dependent. Is it possible to develop an analytic approximation that affords insight into the behavior of a bubble beyond the harmonic approximation of Minnaert? In this spirit, the free radial oscillation of a gas bubble in a fluid is treated as a problem in canonical perturbation theory. Several orders of the expansion are determined in order to explore the dependence of the oscillation frequency with bubble amplitude
Constrained Canonical Correlation.
ERIC Educational Resources Information Center
DeSarbo, Wayne S.; And Others
1982-01-01
A variety of problems associated with the interpretation of traditional canonical correlation are discussed. A response surface approach is developed which allows for investigation of changes in the coefficients while maintaining an optimum canonical correlation value. Also, a discrete or constrained canonical correlation method is presented. (JKS)
Dust in the York canonical basis of ADM tetrad gravity: The problem of vorticity
NASA Astrophysics Data System (ADS)
Alba, David; Lusanna, Luca
2015-05-01
Brown's formulation of dynamical perfect fluids in Minkowski space-time is extended to ADM tetrad gravity in globally hyperbolic, asymptotically Minkowskian space-times. For the dust, we get the Hamiltonian description in closed form in the York canonical basis, where we can separate the inertial gauge variables of the gravitational field in the non-Euclidean 3-spaces of global non-inertial frames from the physical tidal ones. After writing the Hamilton equations of the dust, we identify the sector of irrotational motions and the gauge fixings forcing the dust 3-spaces to coincide with the 3-spaces of the non-inertial frame. The role of the inertial gauge variable York time (the remnant of the clock synchronization gauge freedom) is emphasized. Finally, the Hamiltonian Post-Minkowskian linearization is studied. This formalism is required when one wants to study the Hamiltonian version of cosmological models (for instance back-reaction as an alternative to dark energy) in the York canonical basis.
[Stage III and IV epithelial ovarian cancers. Therapeutic problems].
Picaud, A; Walter, P; Minko Mi Etoua, D; Faye, A; N'Sounda, C; Nlome Nze, A R; Lunven, B
1992-01-01
Between 1986 and 1989 (4 years), 11 epithelial malignant tumours of the ovary were treated in the department of gynecology and obstetrics of the Libreville teaching hospital group. Epithelial tumours accounted for 78 per cent of malignant tumours in the adult. Burkitt's lymphoma predominated in young girls. Cancer of the ovary takes sixth place among female cancers in Gabon, with an incidence identical to that of cancer of the liver. Cases involved stage III and IV malignancies. Four patients died (36 per cent) and seven are still alive (63.6 per cent) with a mean survival of 25 months at the time of the study (the longest living patient having a survival of 5 years). The fullest possible initial surgical excision is essential in ensuring the greater efficacy of polychemotherapy (including Cisplatin), the only guarantee of total second look surgery. Monitoring of residual disease was based upon ultrasonography. Pelvic radiotherapy was used in the presence of a residual pelvic mass measuring less than 3 cm. Future efforts must be direct towards early detection, in particular since more than 45 per cent of our patients were aged under 30. PMID:1565942
The construction of preconditioners for elliptic problems by substructuring, IV
Bramble, J.H.; Pasciak, J.E.; Schatz, A.H.
1987-06-01
We consider the problem of solving the algebraic system of equations which result from the discretization of elliptic boundary value problems defined on three dimensional Euclidean space. We develop preconditioners for such systems based on substructuring (also known as domain decomposition). The resulting algorithms are well suited to emerging parallel computing architectures. We describe two techniques for developing these precondictioners. A theory for the analysis of the condition number for the resulting preconditioned system is given and the results of supporting numerical experiments are presented. 16 refs., 2 tabs.
The construction of preconditioners for elliptic problems by substructuring, IV
Bramble, J.H.; Pasciak, J.E.; Schatz, A.H.
1989-07-01
We consider the problem of solving the algebraic system of equations which result from the discretization of elliptic boundary value problems defined on three-dimensional Euclidean space. We develop preconditioners for such systems based on substructuring (also known as domain decomposition). The resulting algorithms are well suited to emerging parallel computing architectures. We describe two techniques for developing these preconditioners. A theory for the analysis of the condition number for the resulting preconditioned system is given and the results of supporting numerical experiments are presented.
Medical Problems. Child Health and Safety Series (Module IV).
ERIC Educational Resources Information Center
Iscoe, Louise; And Others
This manual for child care personnel in day care homes and centers provides guidelines and information on the detection, treatment, and control of medical problems of children. Introductory materials focus on signs of illness which carepersons can recognize. Section II concentrates on insect, animal and human bites. Section III discusses skin…
Canonical Transformations of Kepler Trajectories
ERIC Educational Resources Information Center
Mostowski, Jan
2010-01-01
In this paper, canonical transformations generated by constants of motion in the case of the Kepler problem are discussed. It is shown that canonical transformations generated by angular momentum are rotations of the trajectory. Particular attention is paid to canonical transformations generated by the Runge-Lenz vector. It is shown that these…
Canonical information analysis
NASA Astrophysics Data System (ADS)
Vestergaard, Jacob Schack; Nielsen, Allan Aasbjerg
2015-03-01
Canonical correlation analysis is an established multivariate statistical method in which correlation between linear combinations of multivariate sets of variables is maximized. In canonical information analysis introduced here, linear correlation as a measure of association between variables is replaced by the information theoretical, entropy based measure mutual information, which is a much more general measure of association. We make canonical information analysis feasible for large sample problems, including for example multispectral images, due to the use of a fast kernel density estimator for entropy estimation. Canonical information analysis is applied successfully to (1) simple simulated data to illustrate the basic idea and evaluate performance, (2) fusion of weather radar and optical geostationary satellite data in a situation with heavy precipitation, and (3) change detection in optical airborne data. The simulation study shows that canonical information analysis is as accurate as and much faster than algorithms presented in previous work, especially for large sample sizes. URL:
Luo, Chongliang; Liu, Jin; Dey, Dipak K; Chen, Kun
2016-07-01
In many fields, multi-view datasets, measuring multiple distinct but interrelated sets of characteristics on the same set of subjects, together with data on certain outcomes or phenotypes, are routinely collected. The objective in such a problem is often two-fold: both to explore the association structures of multiple sets of measurements and to develop a parsimonious model for predicting the future outcomes. We study a unified canonical variate regression framework to tackle the two problems simultaneously. The proposed criterion integrates multiple canonical correlation analysis with predictive modeling, balancing between the association strength of the canonical variates and their joint predictive power on the outcomes. Moreover, the proposed criterion seeks multiple sets of canonical variates simultaneously to enable the examination of their joint effects on the outcomes, and is able to handle multivariate and non-Gaussian outcomes. An efficient algorithm based on variable splitting and Lagrangian multipliers is proposed. Simulation studies show the superior performance of the proposed approach. We demonstrate the effectiveness of the proposed approach in an [Formula: see text] intercross mice study and an alcohol dependence study. PMID:26861909
ERIC Educational Resources Information Center
Bloom, Lynn Z.
1999-01-01
Explores the relation of essays to canon theory, explains why the only essay canon to be publicly identified in the 20th century is a powerful teaching canon. Shows "where essays live," how they arrive in the teaching canon, and why they stay there. Examines how essays are taught. Looks at the future of the essay canon. (SR)
Hao, Jie; Zhu, Jiang; Zhang, Peng; Xin, Si-Yuan; Qi, Dan-Dan; Hu, Ni-Juan; Lin, Chi; Wang, Pei; Zhao, Min-Yi; Hu, Shang-Qing; Wu, Gui-Wen
2015-04-01
In our previous paper, we analyzed "Deqi" in book Huangdi Neijing (The Yellow Emperor's Internal Classic) and Nanjing (Canon of Difficult Medical Problems) from "Zhishen"(Treating mentality) and Tiaoqi (Regulating qi). In the present paper, the authors discuss the connotations of "Deqi" and related events in the later ages of the abovementioned two classic books to the later stage of the Qing Dynasty when involves about 20 classical works as Zhenjiu Dacheng ( The Great Compendium of Acupuncture and Moxibustion), Zhenjing Zhinan (Guide to the classics of Acupuncture), Zhenjiu Daquan (A Complete Works of Acupuncture and Moxibustion) etc. from 1) close association between "Deqi" and patients' mental activity; 2) how to wait for arrival of qi if the needling does not induce "Deqi" for the time being; 3) how to identify "qi-arrival" and then, performing suitable manipulations; 4) Deqi and shallow- or deep-needling; 5) putting more emphasis on patients' feeling and reactions, rather than the practitioners perception beneath the needle which is described in book Huangdi Neijing; and 6) not withdrawing the acupuncture needles if qi does not arrive. Generally, in the later ages, the connotations of Deqi are enriched greatly. PMID:26054205
Olsen, Seth
2015-01-28
This paper reviews basic results from a theory of the a priori classical probabilities (weights) in state-averaged complete active space self-consistent field (SA-CASSCF) models. It addresses how the classical probabilities limit the invariance of the self-consistency condition to transformations of the complete active space configuration interaction (CAS-CI) problem. Such transformations are of interest for choosing representations of the SA-CASSCF solution that are diabatic with respect to some interaction. I achieve the known result that a SA-CASSCF can be self-consistently transformed only within degenerate subspaces of the CAS-CI ensemble density matrix. For uniformly distributed (“microcanonical”) SA-CASSCF ensembles, self-consistency is invariant to any unitary CAS-CI transformation that acts locally on the ensemble support. Most SA-CASSCF applications in current literature are microcanonical. A problem with microcanonical SA-CASSCF models for problems with “more diabatic than adiabatic” states is described. The problem is that not all diabatic energies and couplings are self-consistently resolvable. A canonical-ensemble SA-CASSCF strategy is proposed to solve the problem. For canonical-ensemble SA-CASSCF, the equilibrated ensemble is a Boltzmann density matrix parametrized by its own CAS-CI Hamiltonian and a Lagrange multiplier acting as an inverse “temperature,” unrelated to the physical temperature. Like the convergence criterion for microcanonical-ensemble SA-CASSCF, the equilibration condition for canonical-ensemble SA-CASSCF is invariant to transformations that act locally on the ensemble CAS-CI density matrix. The advantage of a canonical-ensemble description is that more adiabatic states can be included in the support of the ensemble without running into convergence problems. The constraint on the dimensionality of the problem is relieved by the introduction of an energy constraint. The method is illustrated with a complete active space
Sparse Canonical Correlation Analysis: New Formulation and Algorithm.
Chu, Delin; Liao, Li-Zhi; Ng, Michael K; Zhang, Xiaowei
2013-05-24
In this paper, we study canonical correlation analysis (CCA), which has become a powerful tool in multivariate data analysis for finding the correlations between two sets of multidimensional variables. The main contributions of the paper are: (i) to reveal the equivalent relationship between a recursive formula and a trace formula for the multiple CCA problem; (ii) to obtain the explicit characterization of all solutions for the multiple CCA problem even the covariance matrices are singular; (iii) to develop a new sparse CCA algorithm; and (iv) to establish the equivalent relationship between the uncorrelated linear discriminant analysis and the CCA problem. We test several simulated and real world data sets in gene classification and cross-language document retrieval to demonstrate the effectiveness of the proposed algorithm. The performance of the proposed method is competitive with the state-of-the-art sparse CCA algorithms. PMID:23712996
Canonical and non-canonical Notch ligands
D’SOUZA, BRENDAN; MELOTY-KAPELLA, LAURENCE; WEINMASTER, GERRY
2015-01-01
Notch signaling induced by canonical Notch ligands is critical for normal embryonic development and tissue homeostasis through the regulation of a variety of cell fate decisions and cellular processes. Activation of Notch signaling is normally tightly controlled by direct interactions with ligand-expressing cells and dysregulated Notch signaling is associated with developmental abnormalities and cancer. While canonical Notch ligands are responsible for the majority of Notch signaling, a diverse group of structurally unrelated non-canonical ligands has also been identified that activate Notch and likely contribute to the pleiotropic effects of Notch signaling. Soluble forms of both canonical and non-canonical ligands have been isolated, some of which block Notch signaling and could serve as natural inhibitors of this pathway. Ligand activity can also be indirectly regulated by other signaling pathways at the level of ligand expression, serving to spatio-temporally compartmentalize Notch signaling activity and integrate Notch signaling into a molecular network that orchestrates developmental events. Here, we review the molecular mechanisms underlying the dual role of Notch ligands as activators and inhibitors of Notch signaling. Additionally, evidence that Notch ligands function independent of Notch are presented. We also discuss how ligand post-translational modification, endocytosis, proteolysis and spatio-temporal expression regulate their signaling activity. PMID:20816393
Resistant multiple sparse canonical correlation.
Coleman, Jacob; Replogle, Joseph; Chandler, Gabriel; Hardin, Johanna
2016-04-01
Canonical correlation analysis (CCA) is a multivariate technique that takes two datasets and forms the most highly correlated possible pairs of linear combinations between them. Each subsequent pair of linear combinations is orthogonal to the preceding pair, meaning that new information is gleaned from each pair. By looking at the magnitude of coefficient values, we can find out which variables can be grouped together, thus better understanding multiple interactions that are otherwise difficult to compute or grasp intuitively. CCA appears to have quite powerful applications to high-throughput data, as we can use it to discover, for example, relationships between gene expression and gene copy number variation. One of the biggest problems of CCA is that the number of variables (often upwards of 10,000) makes biological interpretation of linear combinations nearly impossible. To limit variable output, we have employed a method known as sparse canonical correlation analysis (SCCA), while adding estimation which is resistant to extreme observations or other types of deviant data. In this paper, we have demonstrated the success of resistant estimation in variable selection using SCCA. Additionally, we have used SCCA to find multiple canonical pairs for extended knowledge about the datasets at hand. Again, using resistant estimators provided more accurate estimates than standard estimators in the multiple canonical correlation setting. R code is available and documented at https://github.com/hardin47/rmscca. PMID:26963062
How to keep up with the medical literature: IV. Using the literature to solve clinical problems.
Haynes, R B; McKibbon, K A; Fitzgerald, D; Guyatt, G H; Walker, C J; Sackett, D L
1986-10-01
Ideally, searches for published articles to solve clinical problems should lead to the best evidence on a given topic quickly and at reasonable expense. This goal can be achieved with modern information skills, sources, and services. In this article, we describe and compare various means, from textbooks to computers, that provide access to information of potential value in addressing clinical problems as they arise. Using the problem of understanding and controlling the risk for the acquired immunodeficiency syndrome among personnel of a community hospital, we examined the following sources for their utility in locating journal literature: general and specialty medical texts, personal reprint collections, expert clinicians, recent journal issues, library textbook collections, the Index Medicus "Bibliography of Reviews" and subject index, and MEDLINE computer searching. For this problem, Index Medicus and MEDLINE were the best sources of up-to-date articles, but MEDLINE was three times as fast. PMID:3530083
ERIC Educational Resources Information Center
Deloria, Vine, Jr., Ed.
As the fourth volume in a five-volume series of position papers on Indian education, this publication presents seven papers relative to the technicalities of the financial, political, and legislative problems of Indian education. Papers are titled as follows: (1) "State Responsibilities for American Indians--Minnesota" (the question of Federal…
Children's Problems Predict Adults' "DSM-IV" Disorders across 24 Years
ERIC Educational Resources Information Center
Reef, Joni; van Meurs, Inge; Verhulst, Frank C.; van der Ende, Jan
2010-01-01
Objective: The goal of this study was to determine continuities of a broad range of psychopathology from childhood into middle adulthood in a general population sample across a 24-year follow-up. Method: In 1983, parent ratings of children's problems were collected with the Child Behavior Checklist (CBCL) in a general population sample of 2,076…
NASA Astrophysics Data System (ADS)
Wiesel, William E.; Pohlen, David J.
1994-01-01
Classical Floquet theory is reviewed with careful attention to the case of repeated eigenvalues common in Hamiltonian systems. Floquet theory generates a canonical transformation to modal variables if the periodic matrix can be made symplectic at the initial time. It is shown that this symplectic normalization can always be carried out, again with careful attention to the degenerate case. The periodic modal vectors and canonical modal variables can always be chosen to be purely real. It is possible to introduce real valued action-angle variables for all modes. Physical interpretation of the canonical degenerate normal modal variables are offered. Finally, it is shown that this transformation enables canonical perturbation theory to be carried out using Floquet modal variables.
Turbulent fluid motion IV-averages, Reynolds decomposition, and the closure problem
NASA Technical Reports Server (NTRS)
Deissler, Robert G.
1992-01-01
Ensemble, time, and space averages as applied to turbulent quantities are discussed, and pertinent properties of the averages are obtained. Those properties, together with Reynolds decomposition, are used to derive the averaged equations of motion and the one- and two-point moment or correlation equations. The terms in the various equations are interpreted. The closure problem of the averaged equations is discussed, and possible closure schemes are considered. Those schemes usually require an input of supplemental information unless the averaged equations are closed by calculating their terms by a numerical solution of the original unaveraged equations. The law of the wall for velocities and temperatures, the velocity- and temperature-defect laws, and the logarithmic laws for velocities and temperatures are derived. Various notions of randomness and their relation to turbulence are considered in light of ergodic theory.
Relations between canonical and non-canonical inflation
Gwyn, Rhiannon; Rummel, Markus; Westphal, Alexander E-mail: markus.rummel@physics.ox.ac.uk
2013-12-01
We look for potential observational degeneracies between canonical and non-canonical models of inflation of a single field φ. Non-canonical inflationary models are characterized by higher than linear powers of the standard kinetic term X in the effective Lagrangian p(X,φ) and arise for instance in the context of the Dirac-Born-Infeld (DBI) action in string theory. An on-shell transformation is introduced that transforms non-canonical inflationary theories to theories with a canonical kinetic term. The 2-point function observables of the original non-canonical theory and its canonical transform are found to match in the case of DBI inflation.
Differential evolution: Global search problem in LEED-IV surface structural analysis
Nascimento, V.B.; Plummer, E.W.
2015-02-15
The search process associated with the quantitative theory–experiment comparison in Low Energy Electron Diffraction surface structural analysis can be very time consuming, especially in the case of complex materials with many atoms in the unit cell. Global search algorithms need to be employed to locate the global minimum of the reliability factor in the multi-dimensional structural parameter space. In this study we investigate the use of the Differential Evolution algorithm in Low Energy Electron Diffraction structural analysis. Despite the simplicity of its mechanism the Differential Evolution algorithm presents an impressive performance when applied to ultra-thin films of BaTiO{sub 3}(001) in a theory–theory comparison. A scaling relation of N{sup (1.47} {sup ±} {sup 0.08)} was obtained, where N is the total number of parameters to be optimized. - Highlights: • We investigated the use of the Differential Evolution algorithm (DE) for the LEED search problem. • The DE method was applied to the optimization of the surface structure of the BaTiO{sub 3}(001) ultra-thin films. • A very favorable scaling relation of N{sup 1.47} was obtained, where N is the total number of parameters to be optimized.
Hori method for generalized canonical systems
NASA Astrophysics Data System (ADS)
da Silva Fernandes, Sandro
2009-01-01
In this paper, some special features on the canonical version of Hori method, when it is applied to generalized canonical systems (systems of differential equations described by a Hamiltonian function linear in the momenta), are presented. Two different procedures, based on a new approach for the integration theory recently presented for the canonical version, are proposed for determining the new Hamiltonian and the generating function for systems whose differential equations for the coordinates describe a periodic system with one fast phase. These procedures are equivalent and they are directly related to the canonical transformations defined by the general solution of the integrable kernel of the Hamiltonian. They provide the same near-identity transformation for the coordinates obtained through the non-canonical version of Hori method. It is also shown that these procedures are connected to the classic averaging principle through a canonical transformation. As examples, asymptotic solutions of a non-linear oscillations problem and of the elliptic perturbed problem are discussed.
NASA Astrophysics Data System (ADS)
You, Setthivoine
2015-11-01
A new canonical field theory has been developed to help interpret the interaction between plasma flows and magnetic fields. The theory augments the Lagrangian of general dynamical systems to rigourously demonstrate that canonical helicity transport is valid across single particle, kinetic and fluid regimes, on scales ranging from classical to general relativistic. The Lagrangian is augmented with two extra terms that represent the interaction between the motion of matter and electromagnetic fields. The dynamical equations can then be re-formulated as a canonical form of Maxwell's equations or a canonical form of Ohm's law valid across all non-quantum regimes. The field theory rigourously shows that helicity can be preserved in kinetic regimes and not only fluid regimes, that helicity transfer between species governs the formation of flows or magnetic fields, and that helicity changes little compared to total energy only if density gradients are shallow. The theory suggests a possible interpretation of particle energization partitioning during magnetic reconnection as canonical wave interactions. This work is supported by US DOE Grant DE-SC0010340.
Canonical and Non-canonical Reelin Signaling.
Bock, Hans H; May, Petra
2016-01-01
Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning during neurodevelopment and is important for synaptic plasticity in the mature brain. Moreover, Reelin is expressed in many extraneuronal tissues; yet the roles of peripheral Reelin are largely unknown. In the brain, many of Reelin's functions are mediated by a molecular signaling cascade that involves two lipoprotein receptors, apolipoprotein E receptor-2 (Apoer2) and very low density-lipoprotein receptor (Vldlr), the neuronal phosphoprotein Disabled-1 (Dab1), and members of the Src family of protein tyrosine kinases as crucial elements. This core signaling pathway in turn modulates the activity of adaptor proteins and downstream protein kinase cascades, many of which target the neuronal cytoskeleton. However, additional Reelin-binding receptors have been postulated or described, either as coreceptors that are essential for the activation of the "canonical" Reelin signaling cascade involving Apoer2/Vldlr and Dab1, or as receptors that activate alternative or additional signaling pathways. Here we will give an overview of canonical and alternative Reelin signaling pathways, molecular mechanisms involved, and their potential physiological roles in the context of different biological settings. PMID:27445693
Canonical vs. micro-canonical sampling methods in a 2D Ising model
Kepner, J.
1990-12-01
Canonical and micro-canonical Monte Carlo algorithms were implemented on a 2D Ising model. Expressions for the internal energy, U, inverse temperature, Z, and specific heat, C, are given. These quantities were calculated over a range of temperature, lattice sizes, and time steps. Both algorithms accurately simulate the Ising model. To obtain greater than three decimal accuracy from the micro-canonical method requires that the more complicated expression for Z be used. The overall difference between the algorithms is small. The physics of the problem under study should be the deciding factor in determining which algorithm to use. 13 refs., 6 figs., 2 tabs.
Canonical floquet perturbation theory
NASA Astrophysics Data System (ADS)
Pohlen, David J.
1992-12-01
Classical Floquet theory is examined in order to generate a canonical transformation to modal variables for periodic system. This transformation is considered canonical if the periodic matrix of eigenvectors is symplectic at the initial time. Approaches for symplectic normalization of the eigenvectors had to be examined for each of the different Poincare eigenvalue cases. Particular attention was required in the degenerate case, which depended on the solution of a generalized eigenvector. Transformation techniques to ensure real modal variables and real periodic eigenvectors were also needed. Periodic trajectories in the restricted three-body case were then evaluated using the canonical Floquet solution. The system used for analyses is the Sun-Jupiter system. This system was especially useful since it contained two of the more difficult Poincare eigenvalue cases, the degenerate case and the imaginary eigenvalue case. The perturbation solution to the canonical modal variables was examined using both an expansion of the Hamiltonian and using a representation that was considered exact. Both methods compared quite well for small perturbations to the initial condition. As expected, the expansion solution failed first due to truncation after the third order term of the expansion.
Canonical and Non-canonical Reelin Signaling
Bock, Hans H.; May, Petra
2016-01-01
Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning during neurodevelopment and is important for synaptic plasticity in the mature brain. Moreover, Reelin is expressed in many extraneuronal tissues; yet the roles of peripheral Reelin are largely unknown. In the brain, many of Reelin’s functions are mediated by a molecular signaling cascade that involves two lipoprotein receptors, apolipoprotein E receptor-2 (Apoer2) and very low density-lipoprotein receptor (Vldlr), the neuronal phosphoprotein Disabled-1 (Dab1), and members of the Src family of protein tyrosine kinases as crucial elements. This core signaling pathway in turn modulates the activity of adaptor proteins and downstream protein kinase cascades, many of which target the neuronal cytoskeleton. However, additional Reelin-binding receptors have been postulated or described, either as coreceptors that are essential for the activation of the “canonical” Reelin signaling cascade involving Apoer2/Vldlr and Dab1, or as receptors that activate alternative or additional signaling pathways. Here we will give an overview of canonical and alternative Reelin signaling pathways, molecular mechanisms involved, and their potential physiological roles in the context of different biological settings. PMID:27445693
The Canonical Passive Construction: Theory and Practice. CLCS Occasional Paper.
ERIC Educational Resources Information Center
El-Marzouk, Ghiath
This paper examines problems with description of the canonical passive construction, noting how new terminology facilitates consideration of a particular approach to frequency asymmetry. It compares the canonical passive construction in Arabic and English as examples of genetically unrelated languages, referring to other languages where…
Canonical Correlation: Terms and Descriptions.
ERIC Educational Resources Information Center
Pugh, Richard C.; Hu, Yuehluen
The use of terms to describe and interpret results from canonical correlation analysis has been inconsistent across research studies. This study assembled the terminology related to the use and interpretation of canonical correlation analysis from research articles, textbooks, and computer manuals. Research articles using canonical correlation…
Canonical fluid thermodynamics
NASA Technical Reports Server (NTRS)
Schmid, L. A.
1972-01-01
The space-time integral of the thermodynamic pressure plays the role of the thermodynamic potential for compressible, adiabatic flow in the sense that the pressure integral for stable flow is less than for all slightly different flows. This stability criterion can be converted into a variational minimum principle by requiring the molar free-enthalpy and the temperature, which are the arguments of the pressure function, to be generalized velocities, that is, the proper-time derivatives of scalar spare-time functions which are generalized coordinates in the canonical formalism. In a fluid context, proper-time differentiation must be expressed in terms of three independent quantities that specify the fluid velocity. This can be done in several ways, all of which lead to different variants (canonical transformations) of the same constraint-free action integral whose Euler-Lagrange equations are just the well-known equations of motion for adiabatic compressible flow.
Canonical gravity with fermions
Bojowald, Martin; Das, Rupam
2008-09-15
Canonical gravity in real Ashtekar-Barbero variables is generalized to allow for fermionic matter. The resulting torsion changes several expressions in Holst's original vacuum analysis, which are summarized here. This in turn requires adaptations to the known loop quantization of gravity coupled to fermions, which is discussed on the basis of the classical analysis. As a result, parity invariance is not manifestly realized in loop quantum gravity.
Canonical forms of multidimensional steady inviscid flows
NASA Technical Reports Server (NTRS)
Taasan, Shlomo
1993-01-01
Canonical forms and canonical variables for inviscid flow problems are derived. In these forms the components of the system governed by different types of operators (elliptic and hyperbolic) are separated. Both the incompressible and compressible cases are analyzed, and their similarities and differences are discussed. The canonical forms obtained are block upper triangular operator form in which the elliptic and non-elliptic parts reside in different blocks. The full nonlinear equations are treated without using any linearization process. This form enables a better analysis of the equations as well as better numerical treatment. These forms are the analog of the decomposition of the one dimensional Euler equations into characteristic directions and Riemann invariants.
Generalized Canonical Time Warping.
Zhou, Feng; De la Torre, Fernando
2016-02-01
Temporal alignment of human motion has been of recent interest due to its applications in animation, tele-rehabilitation and activity recognition. This paper presents generalized canonical time warping (GCTW), an extension of dynamic time warping (DTW) and canonical correlation analysis (CCA) for temporally aligning multi-modal sequences from multiple subjects performing similar activities. GCTW extends previous work on DTW and CCA in several ways: (1) it combines CCA with DTW to align multi-modal data (e.g., video and motion capture data); (2) it extends DTW by using a linear combination of monotonic functions to represent the warping path, providing a more flexible temporal warp. Unlike exact DTW, which has quadratic complexity, we propose a linear time algorithm to minimize GCTW. (3) GCTW allows simultaneous alignment of multiple sequences. Experimental results on aligning multi-modal data, facial expressions, motion capture data and video illustrate the benefits of GCTW. The code is available at http://humansensing.cs.cmu.edu/ctw. PMID:26761734
Backward Variable Elimination Canonical Correlation and Canonical Cross-Validation.
ERIC Educational Resources Information Center
Eason, Sandra
This paper suggests that multivariate analysis techniques are very important in educational research, and that one multivariate technique--canonical correlation analysis--may be particularly useful. The logic of canonical analysis is explained. It is suggested that a backward variable elimination strategy can make the method even more powerful, by…
Regularized Generalized Canonical Correlation Analysis
ERIC Educational Resources Information Center
Tenenhaus, Arthur; Tenenhaus, Michel
2011-01-01
Regularized generalized canonical correlation analysis (RGCCA) is a generalization of regularized canonical correlation analysis to three or more sets of variables. It constitutes a general framework for many multi-block data analysis methods. It combines the power of multi-block data analysis methods (maximization of well identified criteria) and…
ERIC Educational Resources Information Center
Artino, Ralph A., Comp.; And Others
This volume contains the Annual High School Mathematics Examinations given 1973 through 1982, supplementing three previous compilations. The examinations provide challenging problems which teach, stimulate, and provide enjoyment for both participants and readers. In addition to presenting the ten examinations, consisting of 35 problems for the…
Canonical forms for nonlinear systems
NASA Technical Reports Server (NTRS)
Su, R.; Hunt, L. R.; Meyer, G.
1983-01-01
Necessary and sufficient conditions for transforming a nonlinear system to a controllable linear system have been established, and this theory has been applied to the automatic flight control of aircraft. These transformations show that the nonlinearities in a system are often not intrinsic, but are the result of unfortunate choices of coordinates in both state and control variables. Given a nonlinear system (that may not be transformable to a linear system), we construct a canonical form in which much of the nonlinearity is removed from the system. If a system is not transformable to a linear one, then the obstructions to the transformation are obvious in canonical form. If the system can be transformed (it is called a linear equivalent), then the canonical form is a usual one for a controllable linear system. Thus our theory of canonical forms generalizes the earlier transformation (to linear systems) results. Our canonical form is not unique, except up to solutions of certain partial differential equations we discuss. In fact, the important aspect of this paper is the constructive procedure we introduce to reach the canonical form. As is the case in many areas of mathematics, it is often easier to work with the canonical form than in arbitrary coordinate variables.
... 24 hours a day. If there is a problem with the IV, you can call your home health care agency for help. If the IV comes out of ... bleeding stops. Then call the home health care agency or the doctor right away.
Normalization as a canonical neural computation
Carandini, Matteo; Heeger, David J.
2012-01-01
There is increasing evidence that the brain relies on a set of canonical neural computations, repeating them across brain regions and modalities to apply similar operations to different problems. A promising candidate for such a computation is normalization, in which the responses of neurons are divided by a common factor that typically includes the summed activity of a pool of neurons. Normalization was developed to explain responses in the primary visual cortex and is now thought to operate throughout the visual system, and in many other sensory modalities and brain regions. Normalization may underlie operations such as the representation of odours, the modulatory effects of visual attention, the encoding of value and the integration of multisensory information. Its presence in such a diversity of neural systems in multiple species, from invertebrates to mammals, suggests that it serves as a canonical neural computation. PMID:22108672
NASA Astrophysics Data System (ADS)
Tanaka, Kazuo
1995-10-01
The HRD philosophy in R&D in Canon is based on the three-self spirit (self-motivation, self-awareness and self-management). The Canon's R&D engineers are required a positive attitude, creativity and courage to research and to develop new products. Educational measures in optics being in effect in Canon consist of the in-house training courses, studying abroad, publication and others. Several matters which should be noted in education in optics are also discussed; for example, the relationship among geometrical, physical and quantum optics.
Canonical phylogenetic ordination.
Giannini, Norberto P
2003-10-01
A phylogenetic comparative method is proposed for estimating historical effects on comparative data using the partitions that compose a cladogram, i.e., its monophyletic groups. Two basic matrices, Y and X, are defined in the context of an ordinary linear model. Y contains the comparative data measured over t taxa. X consists of an initial tree matrix that contains all the xj monophyletic groups (each coded separately as a binary indicator variable) of the phylogenetic tree available for those taxa. The method seeks to define the subset of groups, i.e., a reduced tree matrix, that best explains the patterns in Y. This definition is accomplished via regression or canonical ordination (depending on the dimensionality of Y) coupled with Monte Carlo permutations. It is argued here that unrestricted permutations (i.e., under an equiprobable model) are valid for testing this specific kind of groupwise hypothesis. Phylogeny is either partialled out or, more properly, incorporated into the analysis in the form of component variation. Direct extensions allow for testing ecomorphological data controlled by phylogeny in a variation partitioning approach. Currently available statistical techniques make this method applicable under most univariate/multivariate models and metrics; two-way phylogenetic effects can be estimated as well. The simplest case (univariate Y), tested with simulations, yielded acceptable type I error rates. Applications presented include examples from evolutionary ethology, ecology, and ecomorphology. Results showed that the new technique detected previously overlooked variation clearly associated with phylogeny and that many phylogenetic effects on comparative data may occur at particular groups rather than across the entire tree. PMID:14530135
Canonical distributions on Riemannian homogeneous k-symmetric spaces
NASA Astrophysics Data System (ADS)
Balashchenko, Vitaly V.
2015-01-01
It is known that distributions generated by almost product structures are applicable, in particular, to some problems in the theory of Monge-Ampère equations. In this paper, we characterize canonical distributions defined by canonical almost product structures on Riemannian homogeneous k-symmetric spaces in the sense of types AF (anti-foliation), F (foliation), TGF (totally geodesic foliation). Algebraic criteria for all these types on k-symmetric spaces of orders k = 4, 5, 6 were obtained. Note that canonical distributions on homogeneous k-symmetric spaces are closely related to special canonical almost complex structures and f-structures, which were recently applied by I. Khemar to studying elliptic integrable systems.
Cooperstock, F.I.
1982-06-15
The analysis of the field equations and the conservation laws is extended into the skin boundary region which maintains the initially static configuration of the two fluid spheres. Although this leads to a correction of the gravitational-radiation energy-loss rate from a dependence of Eapprox...cap alpha../sup -4/rho/sub 0/ /sup -4/ to ..cap alpha../sup -6/rho/sub 0/ /sup -2/, the importance of the nonlinear structure-dependent terms remain and the essential conclusion, that the quadrupole formula does not apply to this problem, is unaltered. The hydrodynamic, stress-breaking, and free-fall time scales are considered. It is shown that insofar as the quadrupole-formula comparison for free-fall is concerned, only the contribution from bulk motion of the fluid spheres need be considered since tidal quadrupole deformation contributes negligibly to the quadrupole formula. With reference to our problem, it is shown that a recent derivation of the quadrupole formula for free-fall is incorrect and it is suggested that certain other derivations may be applicable only to the radiation damping of a single body.
Marini, F; Radin, S; Manganelli, F; Carolo, F; Malagutti, D; Prati, G; Massari, S; Tosi, D; Giarolli, M; Tenci, A
1990-01-01
If we want to enunciate the damaging potential of a bullet fired from a gun we have to express ourselves right from the outset in terms of destructive work, that is to say not only destruction of the structures the bullet passes through, but also, above all, destruction of the homeostatic condition. In modern terms, this is particularly true of the abdomen, which, in perspective, above and beyond any direct involvement, is a candidate for an interesting role. As regards the translation of this destructive force in mathematical language, formulae are proposed in kilogram-meters, feet per second and Joules. A basic factor in external ballistics, quite apart from the actual forces involved, is the trajectory in space, the hyperbola, though we should also reflect on the problem of resistance, which has such a considerable effect on the behaviour of the "ideal" bullet in the atmosphere (the smallest calibre for a given mass, with the attempt to rid itself of its forced subordination to the calibre of the barrel). This leads us on to the subsequent concept of the "ballistic coefficient" and, in itself definitively established the basic assumptions of terminal ballistics. PMID:2076585
Canonical density matrix perturbation theory.
Niklasson, Anders M N; Cawkwell, M J; Rubensson, Emanuel H; Rudberg, Elias
2015-12-01
Density matrix perturbation theory [Niklasson and Challacombe, Phys. Rev. Lett. 92, 193001 (2004)] is generalized to canonical (NVT) free-energy ensembles in tight-binding, Hartree-Fock, or Kohn-Sham density-functional theory. The canonical density matrix perturbation theory can be used to calculate temperature-dependent response properties from the coupled perturbed self-consistent field equations as in density-functional perturbation theory. The method is well suited to take advantage of sparse matrix algebra to achieve linear scaling complexity in the computational cost as a function of system size for sufficiently large nonmetallic materials and metals at high temperatures. PMID:26764847
A Stepwise Canonical Procedure and the Shrinkage of Canonical Correlations.
ERIC Educational Resources Information Center
Rim, Eui-Do
A stepwise canonical procedure, including two selection indices for variable deletion and a rule for stopping the iterative procedure, was derived as a method of selecting core variables from predictors and criteria. The procedure was applied to simulated data varying in the degree of built in structures in population correlation matrices, number…
Romanticism, Sexuality, and the Canon.
ERIC Educational Resources Information Center
Rowe, Kathleen K.
1990-01-01
Traces the Romanticism in the work and persona of film director Jean-Luc Godard. Examines the contradictions posed by Godard's politics and representations of sexuality. Asserts, that by bringing an ironic distance to the works of such canonized directors, viewers can take pleasure in those works despite their contradictions. (MM)
The transport of relative canonical helicity
You, S.
2012-09-15
The evolution of relative canonical helicity is examined in the two-fluid magnetohydrodynamic formalism. Canonical helicity is defined here as the helicity of the plasma species' canonical momentum. The species' canonical helicity are coupled together and can be converted from one into the other while the total gauge-invariant relative canonical helicity remains globally invariant. The conversion is driven by enthalpy differences at a surface common to ion and electron canonical flux tubes. The model provides an explanation for why the threshold for bifurcation in counter-helicity merging depends on the size parameter. The size parameter determines whether magnetic helicity annihilation channels enthalpy into the magnetic flux tube or into the vorticity flow tube components of the canonical flux tube. The transport of relative canonical helicity constrains the interaction between plasma flows and magnetic fields, and provides a more general framework for driving flows and currents from enthalpy or inductive boundary conditions.
General Entropic Approximations for Canonical Systems Described by Kinetic Equations
NASA Astrophysics Data System (ADS)
Pavan, V.
2011-02-01
In this paper we extend the general construction of entropic approximation for kinetic operators modelling canonical systems. More precisely, this paper aims at pursuing to thermalized systems the works of Levermore, Schneider and Junk on moments problems relying on entropy minimization in order to construct BGK approximations and moments based equations.
Functional Multiple-Set Canonical Correlation Analysis
ERIC Educational Resources Information Center
Hwang, Heungsun; Jung, Kwanghee; Takane, Yoshio; Woodward, Todd S.
2012-01-01
We propose functional multiple-set canonical correlation analysis for exploring associations among multiple sets of functions. The proposed method includes functional canonical correlation analysis as a special case when only two sets of functions are considered. As in classical multiple-set canonical correlation analysis, computationally, the…
Canonical Thermal Pure Quantum State
NASA Astrophysics Data System (ADS)
Sugiura, Sho; Shimizu, Akira
2013-07-01
A thermal equilibrium state of a quantum many-body system can be represented by a typical pure state, which we call a thermal pure quantum (TPQ) state. We construct the canonical TPQ state, which corresponds to the canonical ensemble of the conventional statistical mechanics. It is related to the microcanonical TPQ state, which corresponds to the microcanonical ensemble, by simple analytic transformations. Both TPQ states give identical thermodynamic results, if both ensembles do, in the thermodynamic limit. The TPQ states corresponding to other ensembles can also be constructed. We have thus established the TPQ formulation of statistical mechanics, according to which all quantities of statistical-mechanical interest are obtained from a single realization of any TPQ state. We also show that it has great advantages in practical applications. As an illustration, we study the spin-1/2 kagome Heisenberg antiferromagnet.
NASA Astrophysics Data System (ADS)
Michel, Patrick; DeMeo, Francesca E.; Bottke, William F.
. Asteroids, like planets, are driven by a great variety of both dynamical and physical mechanisms. In fact, images sent back by space missions show a collection of small worlds whose characteristics seem designed to overthrow our preconceived notions. Given their wide range of sizes and surface compositions, it is clear that many formed in very different places and at different times within the solar nebula. These characteristics make them an exciting challenge for researchers who crave complex problems. The return of samples from these bodies may ultimately be needed to provide us with solutions. In the book Asteroids IV, the editors and authors have taken major strides in the long journey toward a much deeper understanding of our fascinating planetary ancestors. This book reviews major advances in 43 chapters that have been written and reviewed by a team of more than 200 international authorities in asteroids. It is aimed to be as comprehensive as possible while also remaining accessible to students and researchers who are interested in learning about these small but nonetheless important worlds. We hope this volume will serve as a leading reference on the topic of asteroids for the decade to come. We are deeply indebted to the many authors and referees for their tremendous efforts in helping us create Asteroids IV. We also thank the members of the Asteroids IV scientific organizing committee for helping us shape the structure and content of the book. The conference associated with the book, "Asteroids Comets Meteors 2014" held June 30-July 4, 2014, in Helsinki, Finland, did an outstanding job of demonstrating how much progress we have made in the field over the last decade. We are extremely grateful to our host Karri Muinonnen and his team. The editors are also grateful to the Asteroids IV production staff, namely Renée Dotson and her colleagues at the Lunar and Planetary Institute, for their efforts, their invaluable assistance, and their enthusiasm; they made life as
NASA Astrophysics Data System (ADS)
Michel, Patrick; DeMeo, Francesca E.; Bottke, William F.
. Asteroids, like planets, are driven by a great variety of both dynamical and physical mechanisms. In fact, images sent back by space missions show a collection of small worlds whose characteristics seem designed to overthrow our preconceived notions. Given their wide range of sizes and surface compositions, it is clear that many formed in very different places and at different times within the solar nebula. These characteristics make them an exciting challenge for researchers who crave complex problems. The return of samples from these bodies may ultimately be needed to provide us with solutions. In the book Asteroids IV, the editors and authors have taken major strides in the long journey toward a much deeper understanding of our fascinating planetary ancestors. This book reviews major advances in 43 chapters that have been written and reviewed by a team of more than 200 international authorities in asteroids. It is aimed to be as comprehensive as possible while also remaining accessible to students and researchers who are interested in learning about these small but nonetheless important worlds. We hope this volume will serve as a leading reference on the topic of asteroids for the decade to come. We are deeply indebted to the many authors and referees for their tremendous efforts in helping us create Asteroids IV. We also thank the members of the Asteroids IV scientific organizing committee for helping us shape the structure and content of the book. The conference associated with the book, "Asteroids Comets Meteors 2014" held June 30-July 4, 2014, in Helsinki, Finland, did an outstanding job of demonstrating how much progress we have made in the field over the last decade. We are extremely grateful to our host Karri Muinonnen and his team. The editors are also grateful to the Asteroids IV production staff, namely Renée Dotson and her colleagues at the Lunar and Planetary Institute, for their efforts, their invaluable assistance, and their enthusiasm; they made life as
Alorizi, Seyed Morteza Emami; Nimruzi, Majid
2016-01-01
Background: Stroke has a huge negative impact on the society and more adversely affect women. There is scarce evidence about any neuroprotective effects of commonly used drug in acute stroke. Bushnell et al. provided a guideline focusing on the risk factors of stroke unique to women, including reproductive factors, metabolic syndrome, obesity, atrial fibrillation, and migraine with aura. The ten variables cited by Avicenna in Canon of Medicine would compensate for the gaps mentioned in this guideline. The prescribed drugs should be selected qualitatively opposite to Mizaj (warm-cold and wet-dry qualities induced by disease state) of the disease and according to ten variables, including the nature of the affected organ, intensity of disease, sex, age, habit, season, place of living, occupation, stamina and physical status. Methods: Information related to stroke was searched in Canon of Medicine, which is an outstanding book in traditional Persian medicine written by Avicenna. Results: A hemorrhagic stroke is the result of increasing sanguine humor in the body. Sanguine has warm-wet quality, and should be treated with food and drugs that quench the abundance of blood in the body. An acute episode of ischemic stroke is due to the abundance of phlegm that causes a blockage in the cerebral vessels. Phlegm has cold-wet quality and treatment should be started with compound medicines that either solve the phlegm or eject it from the body. Conclusion: Avicenna has cited in Canon of Medicine that women have cold and wet temperament compared to men. For this reason, they are more prone to accumulation of phlegm in their body organs including the liver, joints and vessels, and consequently in the risk of fatty liver, degenerative joint disease, atherosclerosis, and stroke especially the ischemic one. This is in accordance with epidemiological studies that showed higher rate of ischemic stroke in women rather than hemorrhagic one. PMID:26722147
Quasienergy intergral for canonical maps
Sokolov, V.V.
1986-11-01
Canonical (area-preserving) maps of the phase plane of action-angle variables whose coefficients do not depend explicitly on the number of mapping steps are considered. Just as the absence of an explicit time dependence of the coefficients of a canonical system of differential equations leads to energy conservation, such maps may have an integral of the motion - called a quasienergy integral. It is shown that such an integral can be constructed in the form of a series of analytic functions, a perturbation-theory series, and the superconvergent series of Kolmogorov-Arnol'd-Moser (KAM) theory. These series converge only in limited regions of the phase plane, and their sums have simple poles at fixed (resonance) points of the map. For a sufficiently small perturbation constant g, it is possible to find approximate regular expressions for the quasienergy near any given resonance with any finite accuracy in g. The regions of applicability of the obtained expressions overlap, and this makes it possible to construct at small g an approximate phase portrait of the map on the complete phase plane.
ERIC Educational Resources Information Center
Allegheny County Community Coll., Pittsburgh, PA.
Instructional objectives and performance requirements are outlined in this course guide for Welding IV, a competency-based course in advanced arc welding offered at the Community College of Allegheny County to provide students with proficiency in: (1) single vee groove welding using code specifications established by the American Welding Society…
A canonical approach to forces in molecules
NASA Astrophysics Data System (ADS)
Walton, Jay R.; Rivera-Rivera, Luis A.; Lucchese, Robert R.; Bevan, John W.
2016-08-01
In previous studies, we introduced a generalized formulation for canonical transformations and spectra to investigate the concept of canonical potentials strictly within the Born-Oppenheimer approximation. Data for the most accurate available ground electronic state pairwise intramolecular potentials in H2+, H2, HeH+, and LiH were used to rigorously establish such conclusions. Now, a canonical transformation is derived for the molecular force, F(R), with H2+ as molecular reference. These transformations are demonstrated to be inherently canonical to high accuracy but distinctly different from those corresponding to the respective potentials of H2, HeH+, and LiH. In this paper, we establish the canonical nature of the molecular force which is key to fundamental generalization of canonical approaches to molecular bonding. As further examples Mg2, benzene dimer and to water dimer are also considered within the radial limit as applications of the current methodology.
A canonical form for nonlinear systems
NASA Technical Reports Server (NTRS)
Su, R.; Hunt, L. R.
1986-01-01
The concepts of transformation and canonical form have been used in analyzing linear systems. These ideas are extended to nonlinear systems. A coordinate system and a corresponding canonical form are developed for general nonlinear control systems. Their usefulness is demonstrated by showing that every feedback linearizable system becomes a system with only feedback paths in the canonical form. For control design involving a nonlinear system, one approach is to put the system in its canonical form and approximate by that part having only feedback paths.
NASA Technical Reports Server (NTRS)
2004-01-01
International VLBI Service (IVS) is an international collaboration of organizations which operate or support Very Long Baseline Interferometry (VLBI) components. The goals are: To provide a service to support geodetic, geophysical and astrometric research and operational activities. To promote research and development activities in all aspects of the geodetic and astrometric VLBI technique. To interact with the community of users of VLBI products and to integrate VLBI into a global Earth observing system.
NASA Astrophysics Data System (ADS)
Singh, Parampreet; Soni, S. K.
2016-06-01
The problem of obtaining canonical Hamiltonian structures from the equations of motion, without any knowledge of the action, is studied in the context of the spatially flat Friedmann, ‘Robertson’, and Walker models. Modifications to the Raychaudhuri equation are implemented independently as quadratic and cubic terms of energy density without introducing additional degrees of freedom. Depending on their sign, modifications make gravity repulsive above a curvature scale for matter satisfying strong energy conditions, or more attractive than in the classical theory. The canonical structure of the modified theories is determined by demanding that the total Hamiltonian be a linear combination of gravity and matter Hamiltonians. In the quadratic repulsive case, the modified canonical phase space of gravity is a polymerized phase space with canonical momentum as inverse a trigonometric function of the Hubble rate; the canonical Hamiltonian can be identified with the effective Hamiltonian in loop quantum cosmology. The repulsive cubic modification results in a ‘generalized polymerized’ canonical phase space. Both the repulsive modifications are found to yield singularity avoidance. In contrast, the quadratic and cubic attractive modifications result in a canonical phase space in which canonical momentum is nontrigonometric and singularities persist. Our results hint at connections between the repulsive/attractive nature of modifications to gravity arising from the gravitational sector and polymerized/non polymerized gravitational phase space.
ERIC Educational Resources Information Center
Nimon, Kim; Henson, Robin K.; Gates, Michael S.
2010-01-01
In the face of multicollinearity, researchers face challenges interpreting canonical correlation analysis (CCA) results. Although standardized function and structure coefficients provide insight into the canonical variates produced, they fall short when researchers want to fully report canonical effects. This article revisits the interpretation of…
Place and Summation Coding for Canonical and Non-Canonical Finger Numeral Representations
ERIC Educational Resources Information Center
Di Luca, Samuel; Lefevre, Nathalie; Pesenti, Mauro
2010-01-01
Fingers can be used to express numerical magnitudes, and cultural habits about the fixed order in which fingers are raised determine which configurations become canonical and which non-canonical. Although both types of configuration carry magnitude information, it has been shown that the canonical ones are recognized faster and directly linked to…
NASA Astrophysics Data System (ADS)
Karmakar, Partha; Das, Pradip Kumar; Mondal, Seema Sarkar; Karmakar, Sougata; Mazumdar, Debasis
2010-10-01
Pb pollution from automobile exhausts around highways is a persistent problem in India. Pb intoxication in mammalian body is a complex phenomenon which is influence by agonistic and antagonistic interactions of several other heavy metals and micronutrients. An attempt has been made to study the association between Pb and Zn accumulation in different physiological systems of cattles (n = 200) by application of both canonical correlation and canonical correspondence analyses. Pb was estimated from plasma, liver, bone, muscle, kidney, blood and milk where as Zn was measured from all these systems except bone, blood and milk. Both statistical techniques demonstrated that there was a strong association among blood-Pb, liver-Zn, kidney-Zn and muscle-Zn. From observations, it can be assumed that Zn accumulation in cattles' muscle, liver and kidney directs Pb mobilization from those organs which in turn increases Pb pool in blood. It indicates antagonistic activity of Zn to the accumulation of Pb. Although there were some contradictions between the observations obtained from the two different statistical methods, the overall pattern of Pb accumulation in various organs as influenced by Zn were same. It is mainly due to the fact that canonical correlation is actually a special type of canonical correspondence analyses where linear relationship is followed between two groups of variables instead of Gaussian relationship.
Karmakar, Partha; Das, Pradip Kumar; Mondal, Seema Sarkar; Karmakar, Sougata; Mazumdar, Debasis
2010-10-26
Pb pollution from automobile exhausts around highways is a persistent problem in India. Pb intoxication in mammalian body is a complex phenomenon which is influence by agonistic and antagonistic interactions of several other heavy metals and micronutrients. An attempt has been made to study the association between Pb and Zn accumulation in different physiological systems of cattles (n = 200) by application of both canonical correlation and canonical correspondence analyses. Pb was estimated from plasma, liver, bone, muscle, kidney, blood and milk where as Zn was measured from all these systems except bone, blood and milk. Both statistical techniques demonstrated that there was a strong association among blood-Pb, liver-Zn, kidney-Zn and muscle-Zn. From observations, it can be assumed that Zn accumulation in cattles' muscle, liver and kidney directs Pb mobilization from those organs which in turn increases Pb pool in blood. It indicates antagonistic activity of Zn to the accumulation of Pb. Although there were some contradictions between the observations obtained from the two different statistical methods, the overall pattern of Pb accumulation in various organs as influenced by Zn were same. It is mainly due to the fact that canonical correlation is actually a special type of canonical correspondence analyses where linear relationship is followed between two groups of variables instead of Gaussian relationship.
Properties of the linear canonical integral transformation.
Alieva, Tatiana; Bastiaans, Martin J
2007-11-01
We provide a general expression and different classification schemes for the general two-dimensional canonical integral transformations that describe the propagation of coherent light through lossless first-order optical systems. Main theorems for these transformations, such as shift, scaling, derivation, etc., together with the canonical integral transforms of selected functions, are derived. PMID:17975592
Features of Published Analyses of Canonical Results.
ERIC Educational Resources Information Center
Humphries-Wadsworth, Terresa M.
D. Wood and J. Erskine (1976) and B. Thompson (1989) provided bibliographies of roughly 130 applications of canonical correlation analysis, but the features of such reports have not been widely studied. This report examines the features of recent canonical reports, including substantive inquiries, but also measurement applications examining…
The Current Canon in British Romantics Studies.
ERIC Educational Resources Information Center
Linkin, Harriet Kramer
1991-01-01
Describes and reports on a survey of 164 U.S. universities to ascertain what is taught as the current canon of British Romantic literature. Asserts that the canon may now include Mary Shelley with the former standard six major male Romantic poets, indicating a significant emergence of a feminist perspective on British Romanticism in the classroom.…
Canonical exact coherent structures embedded in high Reynolds number flows.
Deguchi, K; Hall, P
2014-07-28
The applications and implications of two recently addressed asymptotic descriptions of exact coherent structures in shear flows are discussed. The first type of asymptotic framework to be discussed was introduced in a series of papers by Hall & Smith in the 1990s and was referred to as vortex-wave interaction theory (VWI). New results are given here for the canonical VWI problem in an infinite region; the results confirm and extend the results for the infinite problem inferred the recent VWI computation of plane Couette flow. The results given define for the first time exact coherent structures in unbounded flows. The second type of canonical structure described here is that recently found for asymptomatic suction boundary layer and corresponds to freestream coherent structures (FCS), in boundary layer flows. Here, it is shown that the FCS can also occur in flows such as Burgers vortex sheet. It is concluded that both canonical problems can be locally embedded in general shear flows and thus have widespread applicability. PMID:24936006
Multiplicity fluctuations in heavy-ion collisions using canonical and grand-canonical ensemble
NASA Astrophysics Data System (ADS)
Garg, P.; Mishra, D. K.; Netrakanti, P. K.; Mohanty, A. K.
2016-02-01
We report the higher-order cumulants and their ratios for baryon, charge and strangeness multiplicity in canonical and grand-canonical ensembles in ideal thermal model including all the resonances. When the number of conserved quanta is small, an explicit treatment of these conserved charges is required, which leads to a canonical description of the system and the fluctuations are significantly different from the grand-canonical ensemble. Cumulant ratios of total-charge and net-charge multiplicity as a function of collision energies are also compared in grand-canonical ensemble.
Garvey, D.B.; Streets, D.G.
1980-02-01
This is the third volume of a five-volume report, designed to provide useful information for policy analysis in the Department of Energy, especially for the examination of possible areas of conflict between the implementation of a national energy policy calling for the increased use of coal and the pursuit of clean air. Information is presented for each state in Federal Regions IV and VI under the following section headings: state title page (includes a summary of air quality data); revised state implementation plan outline; maps of nonattainment areas, as designated; Storage and Retrieval of Aerometric Data (SAROAD); SAROAD data maps; power plant data; power plant maps; and county maps. States in Federal Region IV include: Alabama, Florida, Georgia, Kentucky, Mississippi, North Carolina, South Carolina, and Tennessee. Those in Federal Region VI include: Arkansas, Louisiana, New Mexico, Oklahoma, and Texas. (JGB)
Garcia Rosales, Alexandra; Vitoratou, Silia; Banaschewski, Tobias; Asherson, Philip; Buitelaar, Jan; Oades, Robert D; Rothenberger, Aribert; Steinhausen, Hans-Christoph; Faraone, Stephen V; Chen, Wai
2015-11-01
In view of ICD-11 revision, we evaluate whether the 18 DSM-IV diagnostic items retained by DSM-5 could be further improved (i) in predicting ADHD 'caseness' and 'impairment' and (ii) discriminating ADHD without CD (ADHD - CD) cases from ADHD with CD (ADHD + CD) cases. In a multi-centre study sample consisting of 1497 ADHD probands and 291 unaffected subjects, 18 diagnostic items were examined for redundancy; then each item was evaluated for association with caseness, impairment and CD status using Classical Test Theory, Item-Response Theory and logistic regression methods. First, all 18 DSM-IV items contributed significantly and independently to the clinical diagnosis of ADHD. Second, not all the DSM-IV items carried equal weighting. "Often loses things", "forgetfulness" and "difficulty sustaining attention" mark severity for Inattentiveness (IA) items and "often unduly noisy", "exhibits a persistent pattern of restlessness", "leaves seat in class" and "often blurts out answers" for Hyperactivity/Impulsivity (HI) items. "Easily distracted", "inattentive to careless mistakes", "often interrupts" and "often fidgets" are associated with milder presentations. In the IA domain, "distracted" yields most information in the low-severity range of the latent trait, "careless" in the mid-severity range and "loses" in the high-severity range. In the HI domains, "interrupts" yields most information in the low-severity range and "motor" in the high-severity range. Third, all 18 items predicted impairment. Fourth, specific ADHD items are associated with ADHD + CD status. The DSM-IV diagnostic items were valid and not redundant; however, some carried more weight than others. All items were associated with impairment. PMID:25743746
Extending canonical Monte Carlo methods
NASA Astrophysics Data System (ADS)
Velazquez, L.; Curilef, S.
2010-02-01
In this paper, we discuss the implications of a recently obtained equilibrium fluctuation-dissipation relation for the extension of the available Monte Carlo methods on the basis of the consideration of the Gibbs canonical ensemble to account for the existence of an anomalous regime with negative heat capacities C < 0. The resulting framework appears to be a suitable generalization of the methodology associated with the so-called dynamical ensemble, which is applied to the extension of two well-known Monte Carlo methods: the Metropolis importance sampling and the Swendsen-Wang cluster algorithm. These Monte Carlo algorithms are employed to study the anomalous thermodynamic behavior of the Potts models with many spin states q defined on a d-dimensional hypercubic lattice with periodic boundary conditions, which successfully reduce the exponential divergence of the decorrelation time τ with increase of the system size N to a weak power-law divergence \\tau \\propto N^{\\alpha } with α≈0.2 for the particular case of the 2D ten-state Potts model.
Canonical Hamiltonians for waves in inhomogeneous media
NASA Astrophysics Data System (ADS)
Gershgorin, Boris; Lvov, Yuri V.; Nazarenko, Sergey
2009-01-01
We obtain a canonical form of a quadratic Hamiltonian for linear waves in a weakly inhomogeneous medium. This is achieved by using the Wentzel-Kramers-Brillouin representation of wave packets. The canonical form of the Hamiltonian is obtained via the series of canonical Bogolyubov-type and near-identical transformations. Various examples of the application illustrating the main features of our approach are presented. The knowledge of the Hamiltonian structure for linear wave systems provides a basis for developing a theory of weakly nonlinear random waves in inhomogeneous media generalizing the theory of homogeneous wave turbulence.
Canonical transient receptor potential 5.
Beech, D J
2007-01-01
Canonical transient receptor potential 5 TRPC5 (also TrpC5, trp-5 or trp5) is one of the seven mammalian TRPC proteins. Its known functional property is that of a mixed cationic plasma membrane channel with calcium permeability. It is active alone or as a heteromultimeric assembly with TRPC1; TRPC4 and TRPC3 may also be involved. Multiple activators of TRPC5 are emerging, including various G protein-coupled receptor agonists, lysophospholipids, lanthanide ions and, in some contexts, calcium store depletion. Intracellular calcium has complex impact on TRPC5, including a permissive role for other activators, as well as inhibition at high concentrations. Protein kinase C is inhibitory and mediates desensitisation following receptor activation. Tonic TRPC5 activity is detected and may reflect the presence of constitutive activation signals. The channel has voltage dependence but the biological significance of this is unknown; it is partially due to intracellular magnesium blockade at aspartic acid residue 633. Protein partners include calmodulin, CaBP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF) and stathmin. TRPC5 is included in local vesicular trafficking regulated by growth factors through phosphatidylinositol (PI)-3-kinase, Rac1 and PIP-5-kinase. Inhibition of myosin light chain kinase suppresses TRPC5, possibly via an effect on trafficking. Biological roles of TRPC5 are emerging but more reports on this aspect are needed. One proposed role is as a mediator of calcium entry and excitation in smooth muscle, another as an inhibitor of neuronal growth cone extension. The latter is intriguing in view of the original cloning of the human TRPC5 gene from a region of the X chromosome linked to mental retardation. TRPC5 is a broadly expressed calcium channel with capability to act as an integrator of extracellular and intracellular signals at the level of calcium entry. PMID:17217053
Absorption cross section of canonical acoustic holes
Crispino, Luis C. B.; Oliveira, Ednilton S.; Matsas, George E. A.
2007-11-15
We compute numerically the absorption cross section of a canonical acoustic hole for sound waves with arbitrary frequencies. Our outputs are in full agreement with the expected low- and high-frequency limits.
Code of Federal Regulations, 2011 CFR
2011-07-01
... REPRESENTATION OF OTHERS BEFORE THE PATENT AND TRADEMARK OFFICE Patent and Trademark Office Code of Professional Responsibility § 10.21 Canon 1. A practitioner should assist in maintaining the integrity and competence of...
Code of Federal Regulations, 2010 CFR
2010-07-01
... REPRESENTATION OF OTHERS BEFORE THE PATENT AND TRADEMARK OFFICE Patent and Trademark Office Code of Professional Responsibility § 10.21 Canon 1. A practitioner should assist in maintaining the integrity and competence of...
Refining inflation using non-canonical scalars
Unnikrishnan, Sanil; Sahni, Varun; Toporensky, Aleksey E-mail: varun@iucaa.ernet.in
2012-08-01
This paper revisits the Inflationary scenario within the framework of scalar field models possessing a non-canonical kinetic term. We obtain closed form solutions for all essential quantities associated with chaotic inflation including slow roll parameters, scalar and tensor power spectra, spectral indices, the tensor-to-scalar ratio, etc. We also examine the Hamilton-Jacobi equation and demonstrate the existence of an inflationary attractor. Our results highlight the fact that non-canonical scalars can significantly improve the viability of inflationary models. They accomplish this by decreasing the tensor-to-scalar ratio while simultaneously increasing the value of the scalar spectral index, thereby redeeming models which are incompatible with the cosmic microwave background (CMB) in their canonical version. For instance, the non-canonical version of the chaotic inflationary potential, V(φ) ∼ λφ{sup 4}, is found to agree with observations for values of λ as large as unity! The exponential potential can also provide a reasonable fit to CMB observations. A central result of this paper is that steep potentials (such as V∝φ{sup −n}) usually associated with dark energy, can drive inflation in the non-canonical setting. Interestingly, non-canonical scalars violate the consistency relation r = −8n{sub T}, which emerges as a smoking gun test for this class of models.
Bolton, Derek
2013-11-01
Criticisms of psychiatry for overdiagnosing, for pathologizing normality, are not new, dating at least from the antipsychiatry critiques in the 1960s. Inevitably, revisions of the diagnostic manuals, the International Classification of Diseases and the Diagnostic and Statistical Manual of Mental Disorders (DSM), provide an occasion for renewed criticism, and the revision process of the DSM-IV became a focus for further debates on overdiagnosis. The debates are typically not about the presence or absence of a decisive marker of specific illnesses or of illness in general-a complex matter on which there is hardly a consensus-but rather about the relative medical, psychosocial, and financial harms and benefits that may accrue from overdiagnosis on the one side and underdiagnosis on the other. It is proposed in this In Review paper that a useful and valid principle for use in these debates is the tight conceptual linkage between illness and distress and impairment of day-to-day functioning. This linkage is fundamental to the conceptualization of mental disorder in the DSM-IV and can still serve to reduce overdiagnosis by excluding cases where distress and impairment are absent or minimal. The same conceptual linkage provides a way of understanding how conditions may warrant a diagnosis even though they are not associated with current distress or impairment, namely, if they carry risk for such in the future. For these conditions, assessments of costs and benefits of overdiagnosis and underdiagnosis depend crucially on high-quality, replicated data on the sensitivity and specificity of the early diagnostic test. PMID:24246431
A Canonical Theory of Dynamic Decision-Making
Fox, John; Cooper, Richard P.; Glasspool, David W.
2012-01-01
Decision-making behavior is studied in many very different fields, from medicine and economics to psychology and neuroscience, with major contributions from mathematics and statistics, computer science, AI, and other technical disciplines. However the conceptualization of what decision-making is and methods for studying it vary greatly and this has resulted in fragmentation of the field. A theory that can accommodate various perspectives may facilitate interdisciplinary working. We present such a theory in which decision-making is articulated as a set of canonical functions that are sufficiently general to accommodate diverse viewpoints, yet sufficiently precise that they can be instantiated in different ways for specific theoretical or practical purposes. The canons cover the whole decision cycle, from the framing of a decision based on the goals, beliefs, and background knowledge of the decision-maker to the formulation of decision options, establishing preferences over them, and making commitments. Commitments can lead to the initiation of new decisions and any step in the cycle can incorporate reasoning about previous decisions and the rationales for them, and lead to revising or abandoning existing commitments. The theory situates decision-making with respect to other high-level cognitive capabilities like problem solving, planning, and collaborative decision-making. The canonical approach is assessed in three domains: cognitive and neuropsychology, artificial intelligence, and decision engineering. PMID:23565100
A spectral canonical electrostatic algorithm
NASA Astrophysics Data System (ADS)
Webb, Stephen D.
2016-03-01
Studying single-particle dynamics over many periods of oscillations is a well-understood problem solved using symplectic integration. Such integration schemes derive their update sequence from an approximate Hamiltonian, guaranteeing that the geometric structure of the underlying problem is preserved. Simulating a self-consistent system over many oscillations can introduce numerical artifacts such as grid heating. This unphysical heating stems from using non-symplectic methods on Hamiltonian systems. With this guidance, we derive an electrostatic algorithm using a discrete form of Hamilton’s principle. The resulting algorithm, a gridless spectral electrostatic macroparticle model, does not exhibit the unphysical heating typical of most particle-in-cell methods. We present results of this using a two-body problem as an example of the algorithm’s energy- and momentum-conserving properties.
BOOK REVIEW: Modern Canonical Quantum General Relativity
NASA Astrophysics Data System (ADS)
Kiefer, Claus
2008-06-01
The open problem of constructing a consistent and experimentally tested quantum theory of the gravitational field has its place at the heart of fundamental physics. The main approaches can be roughly divided into two classes: either one seeks a unified quantum framework of all interactions or one starts with a direct quantization of general relativity. In the first class, string theory (M-theory) is the only known example. In the second class, one can make an additional methodological distinction: while covariant approaches such as path-integral quantization use the four-dimensional metric as an essential ingredient of their formalism, canonical approaches start with a foliation of spacetime into spacelike hypersurfaces in order to arrive at a Hamiltonian formulation. The present book is devoted to one of the canonical approaches—loop quantum gravity. It is named modern canonical quantum general relativity by the author because it uses connections and holonomies as central variables, which are analogous to the variables used in Yang Mills theories. In fact, the canonically conjugate variables are a holonomy of a connection and the flux of a non-Abelian electric field. This has to be contrasted with the older geometrodynamical approach in which the metric of three-dimensional space and the second fundamental form are the fundamental entities, an approach which is still actively being pursued. It is the author's ambition to present loop quantum gravity in a way in which every step is formulated in a mathematically rigorous form. In his own words: 'loop quantum gravity is an attempt to construct a mathematically rigorous, background-independent, non-perturbative quantum field theory of Lorentzian general relativity and all known matter in four spacetime dimensions, not more and not less'. The formal Leitmotiv of loop quantum gravity is background independence. Non-gravitational theories are usually quantized on a given non-dynamical background. In contrast, due to
Communication: Generalized canonical purification for density matrix minimization.
Truflandier, Lionel A; Dianzinga, Rivo M; Bowler, David R
2016-03-01
A Lagrangian formulation for the constrained search for the N-representable one-particle density matrix based on the McWeeny idempotency error minimization is proposed, which converges systematically to the ground state. A closed form of the canonical purification is derived for which no a posteriori adjustment on the trace of the density matrix is needed. The relationship with comparable methods is discussed, showing their possible generalization through the hole-particle duality. The appealing simplicity of this self-consistent recursion relation along with its low computational complexity could prove useful as an alternative to diagonalization in solving dense and sparse matrix eigenvalue problems. PMID:26957150
Communication: Generalized canonical purification for density matrix minimization
NASA Astrophysics Data System (ADS)
Truflandier, Lionel A.; Dianzinga, Rivo M.; Bowler, David R.
2016-03-01
A Lagrangian formulation for the constrained search for the N-representable one-particle density matrix based on the McWeeny idempotency error minimization is proposed, which converges systematically to the ground state. A closed form of the canonical purification is derived for which no a posteriori adjustment on the trace of the density matrix is needed. The relationship with comparable methods is discussed, showing their possible generalization through the hole-particle duality. The appealing simplicity of this self-consistent recursion relation along with its low computational complexity could prove useful as an alternative to diagonalization in solving dense and sparse matrix eigenvalue problems.
Canonical quantization of general relativity in discrete space-times.
Gambini, Rodolfo; Pullin, Jorge
2003-01-17
It has long been recognized that lattice gauge theory formulations, when applied to general relativity, conflict with the invariance of the theory under diffeomorphisms. We analyze discrete lattice general relativity and develop a canonical formalism that allows one to treat constrained theories in Lorentzian signature space-times. The presence of the lattice introduces a "dynamical gauge" fixing that makes the quantization of the theories conceptually clear, albeit computationally involved. The problem of a consistent algebra of constraints is automatically solved in our approach. The approach works successfully in other field theories as well, including topological theories. A simple cosmological application exhibits quantum elimination of the singularity at the big bang. PMID:12570532
Efficient computations of quantum canonical Gibbs state in phase space
NASA Astrophysics Data System (ADS)
Bondar, Denys I.; Campos, Andre G.; Cabrera, Renan; Rabitz, Herschel A.
2016-06-01
The Gibbs canonical state, as a maximum entropy density matrix, represents a quantum system in equilibrium with a thermostat. This state plays an essential role in thermodynamics and serves as the initial condition for nonequilibrium dynamical simulations. We solve a long standing problem for computing the Gibbs state Wigner function with nearly machine accuracy by solving the Bloch equation directly in the phase space. Furthermore, the algorithms are provided yielding high quality Wigner distributions for pure stationary states as well as for Thomas-Fermi and Bose-Einstein distributions. The developed numerical methods furnish a long-sought efficient computation framework for nonequilibrium quantum simulations directly in the Wigner representation.
Grand and Semigrand Canonical Basin-Hopping
2015-01-01
We introduce grand and semigrand canonical global optimization approaches using basin-hopping with an acceptance criterion based on the local contribution of each potential energy minimum to the (semi)grand potential. The method is tested using local harmonic vibrational densities of states for atomic clusters as a function of temperature and chemical potential. The predicted global minima switch from dissociated states to clusters for larger values of the chemical potential and lower temperatures, in agreement with the predictions of a model fitted to heat capacity data for selected clusters. Semigrand canonical optimization allows us to identify particularly stable compositions in multicomponent nanoalloys as a function of increasing temperature, whereas the grand canonical potential can produce a useful survey of favorable structures as a byproduct of the global optimization search. PMID:26669731
Canonical Huynen decomposition of radar targets
NASA Astrophysics Data System (ADS)
Li, Dong; Zhang, Yunhua
2015-10-01
Huynen decomposition prefers the world of basic symmetry and regularity (SR) in which we live. However, this preference restricts its applicability to ideal SR scatterer only. As for the complex non-symmetric (NS) and irregular (IR) scatterers such as forest and building, Huynen decomposition fails to analyze their scattering. The canonical Huynen dichotomy is devised to extend Huynen decomposition to the preferences for IR and NS. From the physical realizability conditions of polarimetric scattering description, two other dichotomies of polarimetric radar target are developed, which prefer scattering IR, and NS, respectively, and provide two competent supplements to Huynen decomposition. The canonical Huynen dichotomy is the combination of the two dichotomies and Huynen decomposition. In virtue of an Adaptive selection, the canonical Huynen dichotomy is used in target extraction, and the experiments on AIRSAR San Francisco data demonstrate its high efficiency and excellent discrimination of radar targets.
Lessons from non-canonical splicing.
Sibley, Christopher R; Blazquez, Lorea; Ule, Jernej
2016-07-01
Recent improvements in experimental and computational techniques that are used to study the transcriptome have enabled an unprecedented view of RNA processing, revealing many previously unknown non-canonical splicing events. This includes cryptic events located far from the currently annotated exons and unconventional splicing mechanisms that have important roles in regulating gene expression. These non-canonical splicing events are a major source of newly emerging transcripts during evolution, especially when they involve sequences derived from transposable elements. They are therefore under precise regulation and quality control, which minimizes their potential to disrupt gene expression. We explain how non-canonical splicing can lead to aberrant transcripts that cause many diseases, and also how it can be exploited for new therapeutic strategies. PMID:27240813
Canonical transformations and Hamiltonian evolutionary systems
Al-Ashhab, Samer
2012-06-15
In many Lagrangian field theories, one has a Poisson bracket defined on the space of local functionals. We find necessary and sufficient conditions for a transformation on the space of local functionals to be canonical in three different cases. These three cases depend on the specific dimensions of the vector bundle of the theory and the associated Hamiltonian differential operator. We also show how a canonical transformation transforms a Hamiltonian evolutionary system and its conservation laws. Finally, we illustrate these ideas with three examples.
Sparse canonical correlation analysis: new formulation and algorithm.
Chu, Delin; Liao, Li-Zhi; Ng, Michael K; Zhang, Xiaowei
2013-12-01
In this paper, we study canonical correlation analysis (CCA), which is a powerful tool in multivariate data analysis for finding the correlation between two sets of multidimensional variables. The main contributions of the paper are: 1) to reveal the equivalent relationship between a recursive formula and a trace formula for the multiple CCA problem, 2) to obtain the explicit characterization for all solutions of the multiple CCA problem even when the corresponding covariance matrices are singular, 3) to develop a new sparse CCA algorithm, and 4) to establish the equivalent relationship between the uncorrelated linear discriminant analysis and the CCA problem. We test several simulated and real-world datasets in gene classification and cross-language document retrieval to demonstrate the effectiveness of the proposed algorithm. The performance of the proposed method is competitive with the state-of-the-art sparse CCA algorithms. PMID:24136440
Heshmat, Ramin; Qorbani, Mostafa; Ghoreshi, Behnaz; Djalalinia, Shirin; Tabatabaie, Omid Reza; Safiri, Saeid; Noroozi, Mehdi; Motlagh, Mohammad-Esmaeil; Ahadi, Zeinab; Asayesh, Hamid; Kelishadi, Roya
2016-01-01
Objectives The aim of the present study was to evaluate the association between socioeconomic status (SES) and psychiatric problems and violent behaviours in a nationally representative sample of Iranian children and adolescents, based on nationwide surveillance programme data, 2011–2012. Methods Overall, 14 880 students, aged 6–18 years, were selected using a multistage cluster sampling method from rural and urban areas of 30 provinces in Iran. SES was estimated based on a main summarised component, extracted from principle component analysis of family assets and parents' jobs and education. For statistical analysis, SES was classified as ‘low’, ‘middle’ and ‘high’. The WHO-Global School Based Student Health Survey (WHO-GSHS) questionnaire was used to assess psychiatric problems and violent behaviours. Results In total, 13 486 students (participation rate 90.6%) completed the study: 50.8% were boys and 75.6% were urban residents, with a mean age of 12.47±3.36 years. In the multivariate model, the ORs of depression, anxiety, feeling worthless, anger, insomnia, confusion and physical fights were lower in students with high SES compared with those with low SES (p<0.05) but physical fights was lower in the high SES group than in the low SES group (p<0.05). No significant relationship was documented between SES and other variables, including getting worried, history of bullying and being victimised. Conclusions Children and adolescents with low SES were at higher risk for psychiatric problems and violent behaviours. Mental health policies and public interventional strategies should be considered at the public level, notably for low SES families. PMID:27531729
Infants' Recognition of Objects Using Canonical Color
ERIC Educational Resources Information Center
Kimura, Atsushi; Wada, Yuji; Yang, Jiale; Otsuka, Yumiko; Dan, Ippeita; Masuda, Tomohiro; Kanazawa, So; Yamaguchi, Masami K.
2010-01-01
We explored infants' ability to recognize the canonical colors of daily objects, including two color-specific objects (human face and fruit) and a non-color-specific object (flower), by using a preferential looking technique. A total of 58 infants between 5 and 8 months of age were tested with a stimulus composed of two color pictures of an object…
Development of Canonical Transformations from Hamilton's Principle.
ERIC Educational Resources Information Center
Quade, C. Richard
1979-01-01
The theory of canonical transformations and its development are discussed with regard to its application to Hutton's principle. Included are the derivation of the equations of motion and a lack of symmetry in the formulaion with respect to Lagrangian and the fundamental commutator relations of quantum mechanics. (Author/SA)
Reflections on a Democratically Constructed Canon
ERIC Educational Resources Information Center
Shafer, Gregory
2003-01-01
American schools have debated the merits of a national canon since the inception of English as a subject a century ago. In earlier years, the mission of the language arts was much more elitist and hierarchical. English was a subject that taught the great works, so that aspiring students could be familiar with the standard pantheon of authors and…
The Redundancy Index in Canonical Correlation Analysis.
ERIC Educational Resources Information Center
Benton, Roberta L.
The redundancy statistic (Rd) is discussed in relation to canonical correlation analysis. The index is a measure of the variance of one set of variables predicted from the linear combination of the other set of variables. A small data set (N=6) from the work of D. Clark (1975) was analyzed using SPSS-X. Two sets of two variables each were…
William Blake and the Literary Canon.
ERIC Educational Resources Information Center
Brogan, Howard O.
1990-01-01
Concludes through an examination of recent criticism of William Blake's works that the literary canon is subject to change over time. Suggests that this is true because of both new critical developments and accumulations of new information through research. Argues that even critical theory is affected by such research. (SG)
Regularized Multiple-Set Canonical Correlation Analysis
ERIC Educational Resources Information Center
Takane, Yoshio; Hwang, Heungsun; Abdi, Herve
2008-01-01
Multiple-set canonical correlation analysis (Generalized CANO or GCANO for short) is an important technique because it subsumes a number of interesting multivariate data analysis techniques as special cases. More recently, it has also been recognized as an important technique for integrating information from multiple sources. In this paper, we…
Canonical Transformation to the Free Particle
ERIC Educational Resources Information Center
Glass, E. N.; Scanio, Joseph J. G.
1977-01-01
Demonstrates how to find some canonical transformations without solving the Hamilton-Jacobi equation. Constructs the transformations from the harmonic oscillator to the free particle and uses these as examples of transformations that cannot be maintained when going from classical to quantum systems. (MLH)
Investigating the Dynamics of Canonical Flux Tubes
NASA Astrophysics Data System (ADS)
von der Linden, Jens; Carroll, Evan; Kamikawa, Yu; Lavine, Eric; Vereen, Keon; You, Setthivoine
2013-10-01
Canonical flux tubes are defined by tracing areas of constant magnetic and fluid vorticity flux. This poster will present the theory for canonical flux tubes and current progress in the construction of an experiment designed to observe their evolution. In the zero flow limit, canonical flux tubes are magnetic flux tubes, but in full form, present the distinct advantage of reconciling two-fluid plasma dynamics with familiar concepts of helicity, twists and linkages. The experiment and the DCON code will be used to investigate a new MHD stability criterion for sausage and kink modes in screw pinches that has been generalized to magnetic flux tubes with skin and core currents. Camera images and a 3D array of ˙ B probes will measure tube aspect-ratio and ratio of current-to-magnetic flux, respectively, to trace these flux tube parameters in a stability space. The experiment's triple electrode planar gun is designed to generate azimuthal and axial flows. These diagnostics together with a 3D vector tomographic reconstruction of ion Doppler spectroscopy will be used to verify the theory of canonical helicity transport. This work was sponsored in part by the US DOE Grant DE-SC0010340.
Temcheff, Caroline E; Paskus, Thomas S; Potenza, Marc N; Derevensky, Jeffrey L
2016-09-01
The current study sought to identify which diagnostic criteria for gambling disorder have the greatest ability to differentiate between social and problem gamblers. This study was conducted on a sample of male and female college student athletes across the U.S. (n = 8674). Classification and regression tree analysis represents an appropriate technique when addressing the question of an item's diagnostic value, as it sequentially selects variables to isolate sets of observations with similar outcomes. The current results suggest that the item related to preoccupation ("Have there been periods in the past year where you spent a lot of time thinking about gambling?") was the DSM-5 item best able to differentiate between male and female social and problem gamblers in this sample. When considering only the nine criteria retained in the DSM-5, three criteria were identified as key for distinguishing between social and disordered gamblers among men, and one criterion was identified for distinguishing between groups of women. In addition, these results do not support the notion that the illegal acts criterion has a particularly low base rate and found that it can be an important indicator of disordered gambling in a college-aged sample. PMID:26846481
Black hole entropy in canonical quantum gravity and superstring theory
Susskind, L.; Uglum, J. )
1994-08-15
In this paper the entropy of an eternal Schwarzschild black hole is studied in the limit of an infinite black hole mass. The problem is addressed from the point of view of both canonical quantum gravity and superstring theory. The entropy per unit area of a free scalar field propagating in a fixed black hole background is shown to be quadratically divergent near the horizon. It is shown that such quantum corrections to the entropy per unit area are equivalent to the quantum corrections to the gravitational coupling. Unlike field theory, superstring theory provides a set of identifiable configurations which give rise to the classical contribution to the entropy per unit area. These configurations can be understood as open superstrings with both ends attached to the horizon. The entropy per unit area is shown to be finite to all orders in superstring perturbation theory. The importance of these conclusions to the resolution of the problem of black hole information loss is reiterated.
Sulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling
Fellgett, Simon W.; Maguire, Richard J.; Pownall, Mary Elizabeth
2015-01-01
ABSTRACT Wnt signalling plays essential roles during embryonic development and is known to be mis-regulated in human disease. There are many molecular mechanisms that ensure tight regulation of Wnt activity. One such regulator is the heparan-sulfate-specific 6-O-endosulfatase Sulf1. Sulf1 acts extracellularly to modify the structure of heparan sulfate chains to affect the bio-availability of Wnt ligands. Sulf1 could, therefore, influence the formation of Wnt signalling complexes to modulate the activation of both canonical and non-canonical pathways. In this study, we use well-established assays in Xenopus to investigate the ability of Sulf1 to modify canonical and non-canonical Wnt signalling. In addition, we model the ability of Sulf1 to influence morphogen gradients using fluorescently tagged Wnt ligands in ectodermal explants. We show that Sulf1 overexpression has ligand-specific effects on Wnt signalling: it affects membrane accumulation and extracellular levels of tagged Wnt8a and Wnt11b ligands differently, and inhibits the activity of canonical Wnt8a but enhances the activity of non-canonical Wnt11b. PMID:25681501
Long, K.R.; Schutte, W.C.
1981-02-01
The insulation industry is essentially self-regulated; therefore, the question arises as to whether or not increased public regulation would be effective in controlling problems associated with the use of urea-formaldehyde foam as residential insulation. The relevancy of public regulation to controlling problems such as off-gassing of formaldehyde associated with the use of the products through the introduction of materials standards and quality assurance of manufacture and installation is discussed. The use of urea-formaldehyde insulation may be divided into three phases-manufacture, installation, and behavioral phases. The relevance of materials standards and quality assurance for each phase is discussed.
Canonical Correlation: Recent Extensions for Modelling Educational Processes.
ERIC Educational Resources Information Center
Thompson, Bruce
Canonical correlation (CC) analysis is discussed with a view toward providing an intuitive understanding of how the technique operates. CC analysis entails calculation of one or more sets of canonical variate coefficients (CVC), i.e., weights which can be applied to the variables in a study. A canonical function (CF) always consists of exactly two…
The Western Canon: The Books and School of the Ages.
ERIC Educational Resources Information Center
Bloom, Harold
This book argues against the politicization of literature and presents a guide to the great works and essential writers of the ages, the "Western Canon." The book studies 26 writers and seeks to isolate the qualities that made these authors canonical, that is, authoritative in Western culture. Noting that although originally the "Canon" meant the…
Canonical Correlation Analysis as a General Analytical Model.
ERIC Educational Resources Information Center
Fan, Xitao
This paper focuses on three aspects related to the conceptualization and application of canonical correlation analysis as a dominant statistical model: (1) partial canonical correlation analysis and its application in statistical testing; (2) the relation between canonical correlation analysis and discriminant analysis; and (3) the relation…
Non-canonical modulators of nuclear receptors.
Tice, Colin M; Zheng, Ya-Jun
2016-09-01
Like G protein-coupled receptors (GPCRs) and protein kinases, nuclear receptors (NRs) are a rich source of pharmaceutical targets. Over 80 NR-targeting drugs have been approved for 18 NRs. The focus of drug discovery in NRs has hitherto been on identifying ligands that bind to the canonical ligand binding pockets of the C-terminal ligand binding domains (LBDs). Due to the development of drug resistance and selectivity concerns, there has been considerable interest in exploring other, non-canonical ligand binding sites. Unfortunately, the potencies of compounds binding at other sites have generally not been sufficient for clinical development. However, the situation has changed dramatically over the last 3years, as compounds with sufficient potency have been reported for several NR targets. Here we review recent developments in this area from a medicinal chemistry point of view in the hope of stimulating further interest in this area of research. PMID:27503683
Spin foam model from canonical quantization
Alexandrov, Sergei
2008-01-15
We suggest a modification of the Barrett-Crane spin foam model of four-dimensional Lorentzian general relativity motivated by the canonical quantization. The starting point is Lorentz covariant loop quantum gravity. Its kinematical Hilbert space is found as a space of the so-called projected spin networks. These spin networks are identified with the boundary states of a spin foam model and provide a generalization of the unique Barrett-Crane intertwiner. We propose a way to modify the Barrett-Crane quantization procedure to arrive at this generalization: the B field (bivectors) should be promoted not to generators of the gauge algebra, but to their certain projection. The modification is also justified by the canonical analysis of the Plebanski formulation. Finally, we compare our construction with other proposals to modify the Barrett-Crane model.
Exon circularization requires canonical splice signals.
Starke, Stefan; Jost, Isabelle; Rossbach, Oliver; Schneider, Tim; Schreiner, Silke; Hung, Lee-Hsueh; Bindereif, Albrecht
2015-01-01
Circular RNAs (circRNAs), an abundant class of noncoding RNAs in higher eukaryotes, are generated from pre-mRNAs by circularization of adjacent exons. Using a set of 15 circRNAs, we demonstrated their cell-type-specific expression and circular versus linear processing in mammalian cells. Northern blot analysis combined with RNase H cleavage conclusively proved a circular configuration for two examples, LPAR1 and HIPK3. To address the circularization mechanism, we analyzed the sequence requirements using minigenes derived from natural circRNAs. Both canonical splice sites are required for circularization, although they vary in flexibility and potential use of cryptic sites. Surprisingly, we found that no specific circRNA exon sequence is necessary and that potential flanking intron structures can modulate circularization efficiency. In combination with splice inhibitor assays, our results argue that the canonical spliceosomal machinery functions in circRNA biogenesis, constituting an alternative splicing mode. PMID:25543144
Covariance and time regained in canonical general relativity
Kouletsis, I.
2008-09-15
observables form only a subset of spacetime observables that are invariant under the transformations of T and X and do not evolve in time. In this generally covariant framework, the conventional interpretation of the canonical theory, due to Bergmann and Dirac, amounts to postulating that the transformations of the reference system (T,X) have no measurable consequences; i.e., that all first-class constraints generate gauge transformations. If this postulate is not deemed necessary, canonical gravity admits no classical problem of time.
Additive discrete 1D linear canonical transform
NASA Astrophysics Data System (ADS)
Zhao, Liang; Healy, John J.; Guo, Chang-liang; Sheridan, John T.
2015-09-01
The continuous linear canonical transforms (LCT) can describe a wide variety of wave field propagations through paraxial (first order) optical systems. Digital algorithms to numerically calculate the LCT are therefore important in modelling scalar wave field propagations and are also of interest for many digital signal processing applications. The continuous LCT is additive, but discretization can remove this property. In this paper we discuss three special cases of the LCT for which constraints can be identified to ensure the DLCT is additive.
Are Young Children's Drawings Canonically Biased?
ERIC Educational Resources Information Center
Picard, Delphine; Durand, Karine
2005-01-01
In a between-subjects design, 4-to 6-year-olds were asked to draw from three-dimensional (3D) models, two-and-a-half-dimensional (212D) models with or without depth cues, or two-dimensional (2D) models of a familiar object (a saucepan) in noncanonical orientations (handle at the back or at the front). Results showed that canonical errors were…
Another Look At The Canon of Plausible Inference
NASA Astrophysics Data System (ADS)
Solana-Ortega, Alberto; Solana, Vicente
2005-11-01
Systematic study of plausible inference is very recent. Axiomatics have been traditionally limited to the development of uninterpreted pure calculi for comparing individual inferences, ignoring the need of formalisms to solve each of these inferences and leaving the interpretation and application of such calculi to ad hoc statistical criteria which are open to inconsistencies. Here we defend a different viewpoint, regarding plausible inference in a holistic manner. Specifically we consider that all tasks involved in it, including the formalization of languages in which to pose problems, the definitions and axiomatics leading to calculation rules and those for deriving inference procedures or assignment rules, ought to be based on common grounds. For this purpose a set of elementary requirements establishing desirable properties so fundamental any theory of scientific inference should satisfy is proposed under the name of plausible inference canon. Its logical status as an extramathematical foundation is investigated, together with the different roles it plays as constructive guideline, standard for contrasting frameworks or normative stipulation. We also highlight the novelties it introduces with respect to similar proposals by other authors. In particular we concentrate on those aspects of the canon related to the critical issue of adequately incorporating basic evidential knowledge to inference.
Stacks in canonical RNA pseudoknot structures.
Han, Hillary S W; Reidys, Christian M
2009-05-01
In this paper we study the distribution of stacks/loops in k-non-crossing, tau-canonical RNA pseudoknot structures (k,tau-structures). Here, an RNA structure is called k-non-crossing if it has no more than k-1 mutually crossing arcs and tau-canonical if each arc is contained in a stack of length at least tau. Based on the ordinary generating function of k,tau-structures [G. Ma, C.M. Reidys, Canonical RNA pseudoknot structures, J. Comput. Biol. 15 (10) (2008) 1257] we derive the bivariate generating function T(k, tau)(x, u) = Sigma(n>or=0)Sigma(0
Canonical energy is quantum Fisher information
NASA Astrophysics Data System (ADS)
Lashkari, Nima; Van Raamsdonk, Mark
2016-04-01
In quantum information theory, Fisher Information is a natural metric on the space of perturbations to a density matrix, defined by calculating the relative entropy with the unperturbed state at quadratic order in perturbations. In gravitational physics, Canonical Energy defines a natural metric on the space of perturbations to spacetimes with a Killing horizon. In this paper, we show that the Fisher information metric for perturbations to the vacuum density matrix of a ball-shaped region B in a holographic CFT is dual to the canonical energy metric for perturbations to a corresponding Rindler wedge R B of Anti-de-Sitter space. Positivity of relative entropy at second order implies that the Fisher information metric is positive definite. Thus, for physical perturbations to anti-de-Sitter spacetime, the canonical energy associated to any Rindler wedge must be positive. This second-order constraint on the metric extends the first order result from relative entropy positivity that physical perturbations must satisfy the linearized Einstein's equations.
Extending canonical Monte Carlo methods: II
NASA Astrophysics Data System (ADS)
Velazquez, L.; Curilef, S.
2010-04-01
We have previously presented a methodology for extending canonical Monte Carlo methods inspired by a suitable extension of the canonical fluctuation relation C = β2langδE2rang compatible with negative heat capacities, C < 0. Now, we improve this methodology by including the finite size effects that reduce the precision of a direct determination of the microcanonical caloric curve β(E) = ∂S(E)/∂E, as well as by carrying out a better implementation of the MC schemes. We show that, despite the modifications considered, the extended canonical MC methods lead to an impressive overcoming of the so-called supercritical slowing down observed close to the region of the temperature driven first-order phase transition. In this case, the size dependence of the decorrelation time τ is reduced from an exponential growth to a weak power-law behavior, \\tau (N)\\propto N^{\\alpha } , as is shown in the particular case of the 2D seven-state Potts model where the exponent α = 0.14-0.18.
Intelligent Virtual Station (IVS)
NASA Technical Reports Server (NTRS)
2002-01-01
The Intelligent Virtual Station (IVS) is enabling the integration of design, training, and operations capabilities into an intelligent virtual station for the International Space Station (ISS). A viewgraph of the IVS Remote Server is presented.
Traditional Herbal Remedies for Burn Wound Healing in Canon of Avicenna
Aliasl, Jale; Khoshzaban, Fariba
2013-01-01
Burns are a worldwide problem. The incidence of severe burns has been higher than the combined incidence of tuberculosis and HIV infections. Throughout history there have been many different treatments prescribed for burns. The Canon is the masterpiece of Avicenna’s medical books. The Canon includes a description of 785 simple drugs. Avicenna believed in burn treatment, which follows two goals. The first goal is prevention of blistering and the second goal is treatment of the burn wound after it has created blisters, cold drugs are suitable for the first goal and dry drugs with moderate in cold and hot qualities are better for second goal, this study reviewed remedies for burn wounds in Canon.
... hyphen, e.g. -historical Searches are case-insensitive Ovarian Cancer Stage IV Add to My Pictures View /Download : ... 1200x1335 View Download Large: 2400x2670 View Download Title: Ovarian Cancer Stage IV Description: Drawing of stage IV shows ...
Yuan, Xue; Cao, Jay; He, Xiaoning; Serra, Rosa; Qu, Jun; Cao, Xu; Yang, Shuying
2016-01-01
Intraflagellar transport proteins (IFT) are required for hedgehog (Hh) signalling transduction that is essential for bone development, however, how IFT proteins regulate Hh signalling in osteoblasts (OBs) remains unclear. Here we show that deletion of ciliary IFT80 in OB precursor cells (OPC) in mice results in growth retardation and markedly decreased bone mass with impaired OB differentiation. Loss of IFT80 blocks canonical Hh–Gli signalling via disrupting Smo ciliary localization, but elevates non-canonical Hh–Gαi–RhoA–stress fibre signalling by increasing Smo and Gαi binding. Inhibition of RhoA and ROCK activity partially restores osteogenic differentiation of IFT80-deficient OPCs by inhibiting non-canonical Hh–RhoA–Cofilin/MLC2 signalling. Cytochalasin D, an actin destabilizer, dramatically restores OB differentiation of IFT80-deficient OPCs by disrupting actin stress fibres and promoting cilia formation and Hh–Gli signalling. These findings reveal that IFT80 is required for OB differentiation by balancing between canonical Hh–Gli and non-canonical Hh–Gαi–RhoA pathways and highlight IFT80 as a therapeutic target for craniofacial and skeletal abnormalities. PMID:26996322
Yuan, Xue; Cao, Jay; He, Xiaoning; Serra, Rosa; Qu, Jun; Cao, Xu; Yang, Shuying
2016-01-01
Intraflagellar transport proteins (IFT) are required for hedgehog (Hh) signalling transduction that is essential for bone development, however, how IFT proteins regulate Hh signalling in osteoblasts (OBs) remains unclear. Here we show that deletion of ciliary IFT80 in OB precursor cells (OPC) in mice results in growth retardation and markedly decreased bone mass with impaired OB differentiation. Loss of IFT80 blocks canonical Hh-Gli signalling via disrupting Smo ciliary localization, but elevates non-canonical Hh-Gαi-RhoA-stress fibre signalling by increasing Smo and Gαi binding. Inhibition of RhoA and ROCK activity partially restores osteogenic differentiation of IFT80-deficient OPCs by inhibiting non-canonical Hh-RhoA-Cofilin/MLC2 signalling. Cytochalasin D, an actin destabilizer, dramatically restores OB differentiation of IFT80-deficient OPCs by disrupting actin stress fibres and promoting cilia formation and Hh-Gli signalling. These findings reveal that IFT80 is required for OB differentiation by balancing between canonical Hh-Gli and non-canonical Hh-Gαi-RhoA pathways and highlight IFT80 as a therapeutic target for craniofacial and skeletal abnormalities. PMID:26996322
Canonical Lie-transform method in Hamiltonian gyrokinetics: a new approach
Nicolini, Piero; Tessarotto, Massimo
2005-05-16
The well-known gyrokinetic problem regards the perturbative expansion related to the dynamics of a charged particle subject to fast gyration motion due to the presence of a strong magnetic field. Although a variety of approaches have been formulated in the past to this well known problem, surprisingly a purely canonical approach based on Lie transform methods is still missing. This paper aims to fill in this gap and provide at the same time new insight in Lie-transform approaches.
Canonical and quasi-canonical probability models of class A interference
NASA Astrophysics Data System (ADS)
Middleton, D.
1983-05-01
It is pointed out that most electromagnetic interference (EMI) phenomena include highly non-Gaussian random processes, whose effects on telecommunication system performance can be severely degrading. In this connection, attention has been given to the development of methods for operating telecommunication equipment in EMI environments. Middleton (1953, 1979, 1981) has developed various forms of canonical interference models. Berry (1980, 1981) has shown that the earlier so-called 'strictly canonical' forms do not cover all situations of practical importance. It is the principal aim of the present investigation to extend work conducted by Middleton (1977, 1979), to include additional source distributions, such as interfering sources at widely distributed distances. A second aim is to establish more precisely the conditions under which the earlier strictly canonical form can still be employed with ignorable error.
Canonical ensemble in non-extensive statistical mechanics, q > 1
NASA Astrophysics Data System (ADS)
Ruseckas, Julius
2016-09-01
The non-extensive statistical mechanics has been used to describe a variety of complex systems. The maximization of entropy, often used to introduce the non-extensive statistical mechanics, is a formal procedure and does not easily lead to physical insight. In this article we investigate the canonical ensemble in the non-extensive statistical mechanics by considering a small system interacting with a large reservoir via short-range forces and assuming equal probabilities for all available microstates. We concentrate on the situation when the reservoir is characterized by generalized entropy with non-extensivity parameter q > 1. We also investigate the problem of divergence in the non-extensive statistical mechanics occurring when q > 1 and show that there is a limit on the growth of the number of microstates of the system that is given by the same expression for all values of q.
Frady, E Paxon; Kapoor, Ashish; Horvitz, Eric; Kristan, William B
2016-08-01
Large-scale data collection efforts to map the brain are underway at multiple spatial and temporal scales, but all face fundamental problems posed by high-dimensional data and intersubject variability. Even seemingly simple problems, such as identifying a neuron/brain region across animals/subjects, become exponentially more difficult in high dimensions, such as recognizing dozens of neurons/brain regions simultaneously. We present a framework and tools for functional neurocartography-the large-scale mapping of neural activity during behavioral states. Using a voltage-sensitive dye (VSD), we imaged the multifunctional responses of hundreds of leech neurons during several behaviors to identify and functionally map homologous neurons. We extracted simple features from each of these behaviors and combined them with anatomical features to create a rich medium-dimensional feature space. This enabled us to use machine learning techniques and visualizations to characterize and account for intersubject variability, piece together a canonical atlas of neural activity, and identify two behavioral networks. We identified 39 neurons (18 pairs, 3 unpaired) as part of a canonical swim network and 17 neurons (8 pairs, 1 unpaired) involved in a partially overlapping preparatory network. All neurons in the preparatory network rapidly depolarized at the onsets of each behavior, suggesting that it is part of a dedicated rapid-response network. This network is likely mediated by the S cell, and we referenced VSD recordings to an activity atlas to identify multiple cells of interest simultaneously in real time for further experiments. We targeted and electrophysiologically verified several neurons in the swim network and further showed that the S cell is presynaptic to multiple neurons in the preparatory network. This study illustrates the basic framework to map neural activity in high dimensions with large-scale recordings and how to extract the rich information necessary to perform
A Canonical Biomechanical Vocal Fold Model
Bhattacharya, Pinaki; Siegmund, Thomas H.
2012-01-01
Summary The present article aimed at constructing a canonical geometry of the human vocal fold (VF) from subject-specific image slice data. A computer-aided design approach automated the model construction. A subject-specific geometry available in literature, three abstractions (which successively diminished in geometric detail) derived from it, and a widely used quasi two-dimensional VF model geometry were used to create computational models. The first three natural frequencies of the models were used to characterize their mechanical response. These frequencies were determined for a representative range of tissue biomechanical properties, accounting for underlying VF histology. Compared with the subject-specific geometry model (baseline), a higher degree of abstraction was found to always correspond to a larger deviation in model frequency (up to 50% in the relevant range of tissue biomechanical properties). The model we deemed canonical was optimally abstracted, in that it significantly simplified the VF geometry compared with the baseline geometry but can be recalibrated in a consistent manner to match the baseline response. Models providing only a marginally higher degree of abstraction were found to have significant deviation in predicted frequency response. The quasi two-dimensional model presented an extreme situation: it could not be recalibrated for its frequency response to match the subject-specific model. This deficiency was attributed to complex support conditions at anterior-posterior extremities of the VFs, accentuated by further issues introduced through the tissue biomechanical properties. In creating canonical models by leveraging advances in clinical imaging techniques, the automated design procedure makes VF modeling based on subject-specific geometry more realizable. PMID:22209063
Canonical Notch activation in osteocytes causes osteopetrosis.
Canalis, Ernesto; Bridgewater, David; Schilling, Lauren; Zanotti, Stefano
2016-01-15
Activation of Notch1 in cells of the osteoblastic lineage inhibits osteoblast differentiation/function and causes osteopenia, whereas its activation in osteocytes causes a distinct osteopetrotic phenotype. To explore mechanisms responsible, we established the contributions of canonical Notch signaling (Rbpjκ dependent) to osteocyte function. Transgenics expressing Cre recombinase under the control of the dentin matrix protein-1 (Dmp1) promoter were crossed with Rbpjκ conditional mice to generate Dmp1-Cre(+/-);Rbpjκ(Δ/Δ) mice. These mice did not have a skeletal phenotype, indicating that Rbpjκ is dispensable for osteocyte function. To study the Rbpjκ contribution to Notch activation, Rosa(Notch) mice, where a loxP-flanked STOP cassette is placed between the Rosa26 promoter and the NICD coding sequence, were crossed with Dmp1-Cre transgenic mice and studied in the context (Dmp1-Cre(+/-);Rosa(Notch);Rbpjκ(Δ/Δ)) or not (Dmp1-Cre(+/-);Rosa(Notch)) of Rbpjκ inactivation. Dmp1-Cre(+/-);Rosa(Notch) mice exhibited increased femoral trabecular bone volume and decreased osteoclasts and bone resorption. The phenotype was reversed in the context of the Rbpjκ inactivation, demonstrating that Notch canonical signaling was accountable for the phenotype. Notch activation downregulated Sost and Dkk1 and upregulated Axin2, Tnfrsf11b, and Tnfsf11 mRNA expression, and these effects were not observed in the context of the Rbpjκ inactivation. In conclusion, Notch activation in osteocytes suppresses bone resorption and increases bone volume by utilization of canonical signals that also result in the inhibition of Sost and Dkk1 and upregulation of Wnt signaling. PMID:26578715
Kato expansion in quantum canonical perturbation theory
NASA Astrophysics Data System (ADS)
Nikolaev, Andrey
2016-06-01
This work establishes a connection between canonical perturbation series in quantum mechanics and a Kato expansion for the resolvent of the Liouville superoperator. Our approach leads to an explicit expression for a generator of a block-diagonalizing Dyson's ordered exponential in arbitrary perturbation order. Unitary intertwining of perturbed and unperturbed averaging superprojectors allows for a description of ambiguities in the generator and block-diagonalized Hamiltonian. We compare the efficiency of the corresponding computational algorithm with the efficiencies of the Van Vleck and Magnus methods for high perturbative orders.
Jacobs, Glenn
2009-01-01
This analysis assesses the factors underlying Charles Horton Cooley's place in the sociological canon as they relate to George Herbert Mead's puzzling diatribe-echoed in secondary accounts-against Cooley's social psychology and view of the self published scarcely a year after his death. The illocutionary act of publishing his critique stands as an effort to project the image of Mead's intellectual self and enhance his standing among sociologists within and outside the orbit of the University of Chicago. It expressed Mead's ambivalence toward his precursor Cooley, whose influence he never fully acknowledged. In addition, it typifies the contending fractal distinctions of the scientifically discursive versus literary styles of Mead and Cooley, who both founded the interpretive sociological tradition. The contrasting styles and attitudes toward writing of the two figures are discussed, and their implications for the problems of scale that have stymied the symbolic interactionist tradition are explored. PMID:19360893
Non-canonical RAN Translation of CGG Repeats Has Canonical Requirements.
Cox, Diana C; Cooper, Thomas A
2016-04-21
Repeat expansions cause dominantly inherited neurological disorders. In this issue of Molecular Cell, Kearse et al. (2016) examine the requirements for RAN translation of the CGG repeats that cause fragile X-associated tremor/ataxia syndrome, revealing similarities and differences with canonical translation. PMID:27105111
Canon Fodder: Young Adult Literature as a Tool for Critiquing Canonicity
ERIC Educational Resources Information Center
Hateley, Erica
2013-01-01
Young adult literature is a tool of socialisation and acculturation for young readers. This extends to endowing "reading" with particular significance in terms of what literature should be read and why. This paper considers some recent young adult fiction with an eye to its engagement with canonical literature and its representations of…
Non-canonical translation in RNA viruses
Brierley, Ian
2012-01-01
Viral protein synthesis is completely dependent upon the translational machinery of the host cell. However, many RNA virus transcripts have marked structural differences from cellular mRNAs that preclude canonical translation initiation, such as the absence of a 5′ cap structure or the presence of highly structured 5′UTRs containing replication and/or packaging signals. Furthermore, whilst the great majority of cellular mRNAs are apparently monocistronic, RNA viruses must often express multiple proteins from their mRNAs. In addition, RNA viruses have very compact genomes and are under intense selective pressure to optimize usage of the available sequence space. Together, these features have driven the evolution of a plethora of non-canonical translational mechanisms in RNA viruses that help them to meet these challenges. Here, we review the mechanisms utilized by RNA viruses of eukaryotes, focusing on internal ribosome entry, leaky scanning, non-AUG initiation, ribosome shunting, reinitiation, ribosomal frameshifting and stop-codon readthrough. The review will highlight recently discovered examples of unusual translational strategies, besides revisiting some classical cases. PMID:22535777
Face hallucination using orthogonal canonical correlation analysis
NASA Astrophysics Data System (ADS)
Zhou, Huiling; Lam, Kin-Man
2016-05-01
A two-step face-hallucination framework is proposed to reconstruct a high-resolution (HR) version of a face from an input low-resolution (LR) face, based on learning from LR-HR example face pairs using orthogonal canonical correlation analysis (orthogonal CCA) and linear mapping. In the proposed algorithm, face images are first represented using principal component analysis (PCA). Canonical correlation analysis (CCA) with the orthogonality property is then employed, to maximize the correlation between the PCA coefficients of the LR and the HR face pairs to improve the hallucination performance. The original CCA does not own the orthogonality property, which is crucial for information reconstruction. We propose using orthogonal CCA, which is proven by experiments to achieve a better performance in terms of global face reconstruction. In addition, in the residual-compensation process, a linear-mapping method is proposed to include both the inter- and intrainformation about manifolds of different resolutions. Compared with other state-of-the-art approaches, the proposed framework can achieve a comparable, or even better, performance in terms of global face reconstruction and the visual quality of face hallucination. Experiments on images with various parameter settings and blurring distortions show that the proposed approach is robust and has great potential for real-world applications.
Observables in classical canonical gravity: Folklore demystified
NASA Astrophysics Data System (ADS)
Pons, J. M.; Salisbury, D. C.; Sundermeyer, K. A.
2010-04-01
We give an overview of some conceptual difficulties, sometimes called paradoxes, that have puzzled for years the physical interpetation of classical canonical gravity and, by extension, the canonical formulation of generally covariant theories. We identify these difficulties as stemming form some terminological misunderstandings as to what is meant by "gauge invariance", or what is understood classically by a "physical state". We make a thorough analysis of the issue and show that all purported paradoxes disappear when the right terminology is in place. Since this issue is connected with the search of observables - gauge invariant quantities - for these theories, we formally show that time evolving observables can be constructed for every observer. This construction relies on the fixation of the gauge freedom of diffeomorphism invariance by means of a scalar coordinatization. We stress the condition that the coordinatization must be made with scalars. As an example of our method for obtaining observables we discuss the case of the massive particle in AdS spacetime.
ADM canonical formalism for gravitating spinning objects
Steinhoff, Jan; Schaefer, Gerhard; Hergt, Steven
2008-05-15
In general relativity, systems of spinning classical particles are implemented into the canonical formalism of Arnowitt, Deser, and Misner [R. Arnowitt, S. Deser, and C. W. Misner, in Gravitation: An Introduction to Current Research, edited by L. Witten (Wiley, New York, 1962), p. 227; arXiv:gr-qc/0405109]. The implementation is made with the aid of a symmetric stress-energy tensor and not a 4-dimensional covariant action functional. The formalism is valid to terms linear in the single spin variables and up to and including the next-to-leading order approximation in the gravitational spin-interaction part. The field-source terms for the spinning particles occurring in the Hamiltonian are obtained from their expressions in Minkowski space with canonical variables through 3-dimensional covariant generalizations as well as from a suitable shift of projections of the curved spacetime stress-energy tensor originally given within covariant spin supplementary conditions. The applied coordinate conditions are the generalized isotropic ones introduced by Arnowitt, Deser, and Misner. As applications, the Hamiltonian of two spinning compact bodies with next-to-leading order gravitational spin-orbit coupling, recently obtained by Damour, Jaranowski, and Schaefer [Phys. Rev. D 77, 064032 (2008)], is rederived and the derivation of the next-to-leading order gravitational spin(1)-spin(2) Hamiltonian, shown for the first time in [J. Steinhoff, S. Hergt, and G. Schaefer, Phys. Rev. D 77, 081501(R) (2008)], is presented.
[Huang Yizhou's study on Nei jing (Inner Canon)].
Hu, Benxiang; Huang, Youmei; Yu, Chengfen
2002-01-01
Being a great classical scholar of the late Qing dynasty, Huang Yizhou collated Nei jing (Inner Canon) by textual criticism. But most of his works were missing. By reviewing historical documents and literature, it has been found that his collated books include Huang di nei jing su wen jiao ben (Collated Edition of Huangdi's Inner Canon Plain Questions), Huang di nei jing su wen chong jiao zheng (Recollated Huangdi's Inner Canon Plain Questions), Nei jing zhen ci (Acupuncture in Inner Canon), Huang di nei jing jiu juan ji zhu (Variorum of Nine Volumes of Huangdi's Inner Canon), Huang di nei jing ming tang (Acupuncture Chart of Huangdi's Inner Canon), and Jiu chao tai su jiao ben (Old Extremely Plain Question Recension). Many of his disciples became famous scholars in the Republican period. PMID:12015056
Energy levels and lifetimes of Nd IV, Pm IV, Sm IV, and Eu IV
Dzuba, V. A.; Safronova, U. I.; Johnson, W. R.
2003-09-01
To address the shortage of experimental data for electron spectra of triply ionized rare-earth elements we have calculated energy levels and lifetimes of 4f{sup n+1} and 4f{sup n}5d configurations of Nd IV (n=2), Pm IV (n=3), Sm IV (n=4), and Eu IV (n=5) using Hartree-Fock and configuration-interaction methods. To control the accuracy of our calculations we also performed similar calculations for Pr III, Nd III, and Sm III, for which experimental data are available. The results are important, in particular, for physics of magnetic garnets.
Education and training in optics conducted at Canon
NASA Astrophysics Data System (ADS)
Tanaka, Kazuo
2002-05-01
The philosophy for human resources development in CANON Inc is based on the three-self spirit (Self-motivation, Self- awareness and Self-management). The Canon's R&D engineers are required a positive attitude, creativity and courage to research and to develop products of innovation. Educational measures in optics being in effect in Canon consist of the in-house training courses, studying abroad, publication and others.
ERIC Educational Resources Information Center
Meller, David V.
This beginning reference manual describes PLATO IV hardware for prospective users and provides an introduction to PLATO for new authors. The PLATO terminal is described in detail in Chapter 1. Chapter 2 provides a block diagram of the PLATO IV system. Procedures for getting on line are described in Chapter 3, and Chapter 4 provides references to…
Canonical and non-canonical Hedgehog signalling and the control of metabolism
Teperino, Raffaele; Aberger, Fritz; Esterbauer, Harald; Riobo, Natalia; Pospisilik, John Andrew
2014-01-01
Obesity and diabetes represent key healthcare challenges of our day, affecting upwards of one billion people worldwide. These individuals are at higher risk for cancer, stroke, blindness, heart and cardiovascular disease, and to date, have no effective long-term treatment options available. Recent and accumulating evidence has implicated the developmental morphogen Hedgehog and its downstream signalling in metabolic control. Generally thought to be quiescent in adults, Hedgehog is associated with several human cancers, and as such, has already emerged as a therapeutic target in oncology. Here, we attempt to give a comprehensive overview of the key signalling events associated with both canonical and non-canonical Hedgehog signalling, and highlight the increasingly complex regulatory modalities that appear to link Hedgehog and control metabolism. We highlight these key findings and discuss their impact for therapeutic development, cancer and metabolic disease. PMID:24862854
Implementation of Real-Time Feedback Flow Control Algorithms on a Canonical Testbed
NASA Technical Reports Server (NTRS)
Tian, Ye; Song, Qi; Cattafesta, Louis
2005-01-01
This report summarizes the activities on "Implementation of Real-Time Feedback Flow Control Algorithms on a Canonical Testbed." The work summarized consists primarily of two parts. The first part summarizes our previous work and the extensions to adaptive ID and control algorithms. The second part concentrates on the validation of adaptive algorithms by applying them to a vibration beam test bed. Extensions to flow control problems are discussed.
Facial expression recognition using kernel canonical correlation analysis (KCCA).
Zheng, Wenming; Zhou, Xiaoyan; Zou, Cairong; Zhao, Li
2006-01-01
In this correspondence, we address the facial expression recognition problem using kernel canonical correlation analysis (KCCA). Following the method proposed by Lyons et al. and Zhang et al., we manually locate 34 landmark points from each facial image and then convert these geometric points into a labeled graph (LG) vector using the Gabor wavelet transformation method to represent the facial features. On the other hand, for each training facial image, the semantic ratings describing the basic expressions are combined into a six-dimensional semantic expression vector. Learning the correlation between the LG vector and the semantic expression vector is performed by KCCA. According to this correlation, we estimate the associated semantic expression vector of a given test image and then perform the expression classification according to this estimated semantic expression vector. Moreover, we also propose an improved KCCA algorithm to tackle the singularity problem of the Gram matrix. The experimental results on the Japanese female facial expression database and the Ekman's "Pictures of Facial Affect" database illustrate the effectiveness of the proposed method. PMID:16526490
Canonical and non-canonical Wnt proteins program dendritic cell responses for tolerance
Oderup, Cecilia; LaJevic, Melissa; Butcher, Eugene C.
2013-01-01
Antigen presenting dendritic cells (DC) interpret environmental signals to orchestrate local and systemic immune responses. They govern the balance between tolerance and inflammation at epithelial surfaces, where the immune system must provide robust pathogen responses while maintaining tolerance to commensal flora and food antigens. The Wnt family of secreted proteins, which control epithelial as well as hematopoietic development and homeostasis, is emerging as an important regulator of inflammation. Here we show that canonical and non-canonical Wnts directly stimulate murine DC production of anti-inflammatory cytokines. Wnt3A triggers canonical β-catenin signaling and preferentially induces DC TGF-β and VEGF production, whereas Wnt5A induces IL-10 through alternative pathways. The Wnts also alter DC responses to microbe- or pathogen-associated molecular patterns (PAMPs), inhibiting pro-inflammatory cytokine induction in response to toll like receptor ligands and promoting DC generation of Foxp3+ regulatory T cells. Moreover, although both Wnts suppress pro-inflammatory responses to bacterial endotoxin and to TLR1/2, TLR7 and TLR9 ligands, Wnt5A but not Wnt3A inhibits IL-6 production in response to the viral mimic, polyinosinic:polycytidylic acid. Wnt family members thus directly and differentially regulate DC functions, an ability that may contribute to the balance between tolerance and inflammation at epithelial sites of exposure to microbes and environmental antigens. PMID:23677472
The Academic Librarian and the Hegemony of the Canon.
ERIC Educational Resources Information Center
Doherty, John J.
1998-01-01
Discusses academic library collection-development theory and policy. Suggests that a standard collection of works specific to each discipline (a canon), is a powerful tool because such canons can censor the works that fall outside of the prevailing norms, the hegemony of the discipline. (LRW)
Geothermal resource assessment of Canon City, Colorado Area
Zacharakis, Ted G.; Pearl, Richard Howard
1982-01-01
In 1979 a program was initiated to fully define the geothermal conditions of an area east of Canon City, bounded by the mountains on the north and west, the Arkansas River on the south and Colorado Highway 115 on the east. Within this area are a number of thermal springs and wells in two distinct groups. The eastern group consists of 5 thermal artesian wells located within one mile of Colorado Highway 115 from Penrose on the north to the Arkansas river on the south. The western group, located in and adjacent to Canon City, consists of one thermal spring on the south bank of the Arkansas River on the west side of Canon City, a thermal well in the northeast corner of Canon City, another well along the banks of Four Mile Creek east of Canon City and a well north of Canon City on Four Mile Creek. All the thermal waters in the Canon City Embayment, of which the study area is part of, are found in the study area. The thermal waters unlike the cold ground waters of the Canon City Embayment, are a calcium-bicarbonate type and range in temperature from 79 F (26 C) to a high of 108 F (42 C). The total combined surface discharge o fall the thermal water in the study area is in excess of 532 acre feet (A.F.) per year.
Canonical Correlation Analysis: An Explanation with Comments on Correct Practice.
ERIC Educational Resources Information Center
Thompson, Bruce
This paper briefly explains the logic underlying the basic calculations employed in canonical correlation analysis. A small hypothetical data set is employed to illustrate that canonical correlation analysis subsumes both univariate and multivariate parametric methods. Several real data sets are employed to illustrate other themes. Three common…
Canonical Slippage: Why Have All the Poems Gone?
ERIC Educational Resources Information Center
Dias, Patrick
2002-01-01
Discusses many ideas the author has regarding the literature canon including what he thinks should be taught and for what reasons. Makes a case for the classroom contexts that allow students to develop into confident, enthusiastic, and responsible readers of canonical poetry. (SG)
The Asian American Fakeness Canon, 1972-2002
ERIC Educational Resources Information Center
Oishi, Eve
2007-01-01
The year 1972 can be seen to inaugurate not a tradition of Asian American New York theater, but the rich and multigenre collection of writing that the author has called "the Asian American fakeness canon." The fakeness canon refers to a collection of writings that take as one of their central points of reference the question of cultural and ethnic…
The Effects of Rotation in Canonical Correlation Analysis.
ERIC Educational Resources Information Center
Jones, Gail
Through a review of the literature, this paper explores the viability of the rotation of canonical correlation analysis results. The similarities and dissimilarities between factor analysis and canonical correlation analysis are examined. The logic supporting a preference for the rotation of structure coefficients as opposed to function…
Critical Literature Pedagogy: Teaching Canonical Literature for Critical Literacy
ERIC Educational Resources Information Center
Borsheim-Black, Carlin; Macaluso, Michael; Petrone, Robert
2014-01-01
This article introduces Critical Literature Pedagogy (CLP), a pedagogical framework for applying goals of critical literacy within the context of teaching canonical literature. Critical literacies encompass skills and dispositions to understand, question, and critique ideological messages of texts; because canonical literature is often…
Structuring Catholic Schools: Creative Imagination Meets Canon Law
ERIC Educational Resources Information Center
Brown, Phillip J.
2010-01-01
This paper will explore the underlying requirements of canon law for establishing and administering Catholic schools, with a view toward helping to arrive at creative solutions to the question of how best to structure these schools civilly and canonically in order to ensure their temporal, spiritual, and religious well-being, and to assure that…
El Escritor y las Normas del Canon Literario (The Writer and the Norms of the Literary Canon).
ERIC Educational Resources Information Center
Policarpo, Alcibiades
This paper speculates about whether a literary canon exists in contemporary Latin American literature, particularly in the prose genre. The paper points to Carlos Fuentes, Gabriel Garcia Marquez, and Mario Vargas Llosa as the three authors who might form this traditional and liberal canon with their works "La Muerte de Artemio Cruz" (Fuentes),…
... home; PICC line - home; Infusion therapy - home; Home health care - IV treatment ... Often, home health care nurses will come to your home to give you the medicine. Sometimes, a family member, a friend, or ...
NASA Technical Reports Server (NTRS)
Mortensen, L. O.
1982-01-01
The Mark IV ground communication facility (GCF) as it is implemented to support the network consolidation program is reviewed. Changes in the GCF are made in the area of increased capacity. Common carrier circuits are the medium for data transfer. The message multiplexing in the Mark IV era differs from the Mark III era, in that all multiplexing is done in a GCF computer under GCF software control, which is similar to the multiplexing currently done in the high speed data subsystem.
Shannon Entropy of the Canonical Genetic Code
NASA Astrophysics Data System (ADS)
Nemzer, Louis
The probability that a non-synonymous point mutation in DNA will adversely affect the functionality of the resultant protein is greatly reduced if the substitution is conservative. In that case, the amino acid coded by the mutated codon has similar physico-chemical properties to the original. Many simplified alphabets, which group the 20 common amino acids into families, have been proposed. To evaluate these schema objectively, we introduce a novel, quantitative method based on the inherent redundancy in the canonical genetic code. By calculating the Shannon information entropy carried by 1- or 2-bit messages, groupings that best leverage the robustness of the code are identified. The relative importance of properties related to protein folding - like hydropathy and size - and function, including side-chain acidity, can also be estimated. In addition, this approach allows us to quantify the average information value of nucleotide codon positions, and explore the physiological basis for distinguishing between transition and transversion mutations. Supported by NSU PFRDG Grant #335347.
Finite canonical measure for nonsingular cosmologies
Page, Don N.
2011-06-01
The total canonical (Liouville-Henneaux-Gibbons-Hawking-Stewart) measure is finite for completely nonsingular Friedmann-Lemaître-Robertson-Walker classical universes with a minimally coupled massive scalar field and a positive cosmological constant. For a cosmological constant very small in units of the square of the scalar field mass, most of the measure is for nearly de Sitter solutions with no inflation at a much more rapid rate. However, if one restricts to solutions in which the scalar field energy density is ever more than twice the equivalent energy density of the cosmological constant, then the number of e-folds of rapid inflation must be large, and the fraction of the measure is low in which the spatial curvature is comparable to the cosmological constant at the time when it is comparable to the energy density of the scalar field. The measure for such classical FLRWΛ-φ models with both a big bang and a big crunch is also finite. Only the solutions with a big bang that expand forever, or the time-reversed ones that contract from infinity to a big crunch, have infinite measure.
Canonical quantization of Galilean covariant field theories
NASA Astrophysics Data System (ADS)
Santos, E. S.; de Montigny, M.; Khanna, F. C.
2005-11-01
The Galilean-invariant field theories are quantized by using the canonical method and the five-dimensional Lorentz-like covariant expressions of non-relativistic field equations. This method is motivated by the fact that the extended Galilei group in 3 + 1 dimensions is a subgroup of the inhomogeneous Lorentz group in 4 + 1 dimensions. First, we consider complex scalar fields, where the Schrödinger field follows from a reduction of the Klein-Gordon equation in the extended space. The underlying discrete symmetries are discussed, and we calculate the scattering cross-sections for the Coulomb interaction and for the self-interacting term λΦ4. Then, we turn to the Dirac equation, which, upon dimensional reduction, leads to the Lévy-Leblond equations. Like its relativistic analogue, the model allows for the existence of antiparticles. Scattering amplitudes and cross-sections are calculated for the Coulomb interaction, the electron-electron and the electron-positron scattering. These examples show that the so-called 'non-relativistic' approximations, obtained in low-velocity limits, must be treated with great care to be Galilei-invariant. The non-relativistic Proca field is discussed briefly.
Non-canonical inflation in supergravity
NASA Astrophysics Data System (ADS)
Gwyn, Rhiannon; Lehners, Jean-Luc
2014-05-01
We investigate the effect of non-canonical kinetic terms on inflation in supergravity. We find that the biggest impact of such higher-derivative kinetic terms is due to the corrections to the potential that they induce via their effect on the auxiliary fields, which now have a cubic equation of motion. This is in contrast to the usual (non-supersymmetric) effective field theory expansion which assumes that mass-suppressed higher-derivative terms do not affect the lower-derivative terms already present. We demonstrate with several examples that such changes in the potential can significantly modify the inflationary dynamics. Our results have immediate implications for effective descriptions of inflation derived from string theory, where higher-derivative kinetic terms are generally present. In addition we elucidate the structure of the theory in the parameter range where there are three real solutions to the auxiliary field's equation of motion, studying the resulting three branches of the theory, and finding that one of them suffers from a singularity in the speed of propagation of fluctuations.
On a canonical quantization of 3D Anti de Sitter pure gravity
NASA Astrophysics Data System (ADS)
Kim, Jihun; Porrati, Massimo
2015-10-01
We perform a canonical quantization of pure gravity on AdS 3 using as a technical tool its equivalence at the classical level with a Chern-Simons theory with gauge group SL(2,{R})× SL(2,{R}) . We first quantize the theory canonically on an asymptotically AdS space -which is topologically the real line times a Riemann surface with one connected boundary. Using the "constrain first" approach we reduce canonical quantization to quantization of orbits of the Virasoro group and Kähler quantization of Teichmüller space. After explicitly computing the Kähler form for the torus with one boundary component and after extending that result to higher genus, we recover known results, such as that wave functions of SL(2,{R}) Chern-Simons theory are conformal blocks. We find new restrictions on the Hilbert space of pure gravity by imposing invariance under large diffeomorphisms and normalizability of the wave function. The Hilbert space of pure gravity is shown to be the target space of Conformal Field Theories with continuous spectrum and a lower bound on operator dimensions. A projection defined by topology changing amplitudes in Euclidean gravity is proposed. It defines an invariant subspace that allows for a dual interpretation in terms of a Liouville CFT. Problems and features of the CFT dual are assessed and a new definition of the Hilbert space, exempt from those problems, is proposed in the case of highly-curved AdS 3.
Critical adsorption and critical Casimir forces in the canonical ensemble.
Gross, Markus; Vasilyev, Oleg; Gambassi, Andrea; Dietrich, S
2016-08-01
Critical properties of a liquid film between two planar walls are investigated in the canonical ensemble, within which the total number of fluid particles, rather than their chemical potential, is kept constant. The effect of this constraint is analyzed within mean-field theory (MFT) based on a Ginzburg-Landau free-energy functional as well as via Monte Carlo simulations of the three-dimensional Ising model with fixed total magnetization. Within MFT and for finite adsorption strengths at the walls, the thermodynamic properties of the film in the canonical ensemble can be mapped exactly onto a grand canonical ensemble in which the corresponding chemical potential plays the role of the Lagrange multiplier associated with the constraint. However, due to a nonintegrable divergence of the mean-field order parameter profile near a wall, the limit of infinitely strong adsorption turns out to be not well-defined within MFT, because it would necessarily violate the constraint. The critical Casimir force (CCF) acting on the two planar walls of the film is generally found to behave differently in the canonical and grand canonical ensembles. For instance, the canonical CCF in the presence of equal preferential adsorption at the two walls is found to have the opposite sign and a slower decay behavior as a function of the film thickness compared to its grand canonical counterpart. We derive the stress tensor in the canonical ensemble and find that it has the same expression as in the grand canonical case, but with the chemical potential playing the role of the Lagrange multiplier associated with the constraint. The different behavior of the CCF in the two ensembles is rationalized within MFT by showing that, for a prescribed value of the thermodynamic control parameter of the film, i.e., density or chemical potential, the film pressures are identical in the two ensembles, while the corresponding bulk pressures are not. PMID:27627242
Critical adsorption and critical Casimir forces in the canonical ensemble
NASA Astrophysics Data System (ADS)
Gross, Markus; Vasilyev, Oleg; Gambassi, Andrea; Dietrich, S.
2016-08-01
Critical properties of a liquid film between two planar walls are investigated in the canonical ensemble, within which the total number of fluid particles, rather than their chemical potential, is kept constant. The effect of this constraint is analyzed within mean-field theory (MFT) based on a Ginzburg-Landau free-energy functional as well as via Monte Carlo simulations of the three-dimensional Ising model with fixed total magnetization. Within MFT and for finite adsorption strengths at the walls, the thermodynamic properties of the film in the canonical ensemble can be mapped exactly onto a grand canonical ensemble in which the corresponding chemical potential plays the role of the Lagrange multiplier associated with the constraint. However, due to a nonintegrable divergence of the mean-field order parameter profile near a wall, the limit of infinitely strong adsorption turns out to be not well-defined within MFT, because it would necessarily violate the constraint. The critical Casimir force (CCF) acting on the two planar walls of the film is generally found to behave differently in the canonical and grand canonical ensembles. For instance, the canonical CCF in the presence of equal preferential adsorption at the two walls is found to have the opposite sign and a slower decay behavior as a function of the film thickness compared to its grand canonical counterpart. We derive the stress tensor in the canonical ensemble and find that it has the same expression as in the grand canonical case, but with the chemical potential playing the role of the Lagrange multiplier associated with the constraint. The different behavior of the CCF in the two ensembles is rationalized within MFT by showing that, for a prescribed value of the thermodynamic control parameter of the film, i.e., density or chemical potential, the film pressures are identical in the two ensembles, while the corresponding bulk pressures are not.
Wu, Guo Rong; Chen, Fuyong; Kang, Dezhi; Zhang, Xiangyang; Marinazzo, Daniele; Chen, Huafu
2011-11-01
Multivariate Granger causality is a well-established approach for inferring information flow in complex systems, and it is being increasingly applied to map brain connectivity. Traditional Granger causality is based on vector autoregressive (AR) or mixed autoregressive moving average (ARMA) model, which are potentially affected by errors in parameter estimation and may be contaminated by zero-lag correlation, notably when modeling neuroimaging data. To overcome this issue, we present here an extended canonical correlation approach to measure multivariate Granger causal interactions among time series. The procedure includes a reduced rank step for calculating canonical correlation analysis (CCA), and extends the definition of causality including instantaneous effects, thus avoiding the potential estimation problems of AR (or ARMA) models. We tested this approach on simulated data and confirmed its practical utility by exploring local network connectivity at different scales in the epileptic brain analyzing scalp and depth-EEG data during an interictal period. PMID:21788178
Exact canonically conjugate momenta approach to a one-dimensional neutron-proton system, I
NASA Astrophysics Data System (ADS)
Nishiyama, Seiya; da Providência, João
2015-06-01
Introducing collective variables, a collective description of nuclear surface oscillations has been developed with the first-quantized language, contrary to the second-quantized one in Sunakawa's approach for a Bose system. It overcomes difficulties remaining in the traditional theories of nuclear collective motions: Collective momenta are not exact canonically conjugate to collective coordinates and are not independent. On the contrary to such a description, Tomonaga first gave the basic idea to approach elementary excitations in a one-dimensional Fermi system. The Sunakawa's approach for a Fermi system is also expected to work well for such a problem. In this paper, on the isospin space, we define a density operator and further following Tomonaga, introduce a collective momentum. We propose an exact canonically momenta approach to a one-dimensional neutron-proton (N-P) system under the use of the Grassmann variables.
Toward a medical-concept representation language. The Canon Group.
Evans, D A; Cimino, J J; Hersh, W R; Huff, S M; Bell, D S
1994-01-01
The Canon Group is an informal organization of medical informatics researchers who are working on the problem of developing a "deeper" representation formalism for use in exchanging data and developing applications. Individuals in the group represent experts in such areas as knowledge representation and computational linguistics, as well as in a variety of medical subdisciplines. All share the view that current mechanisms for the characterization of medical phenomena are either inadequate (limited or rigid) or idiosyncratic (useful for a specific application but incapable of being generalized or extended). The Group proposes to focus on the design of a general schema for medical-language representation including the specification of the resources and associated procedures required to map language (including standard terminologies) into representations that make all implicit relations "visible," reveal "hidden attributes," and generally resolve ambiguous or vague references. The Group is proceeding by examining large numbers of texts (records) in medical sub-domains to identify candidate "concepts" and by attempting to develop general rules and representations for elements such as attributes and values so that all concepts may be expressed uniformly. PMID:7719804
NASA Astrophysics Data System (ADS)
Hillaris, A.; Bouratzis, C.; Nindos, A.
2016-08-01
We study the characteristics of moving type IV radio bursts that extend to hectometric wavelengths (interplanetary type IV or type {IV}_{{IP}} bursts) and their relationship with energetic phenomena on the Sun. Our dataset comprises 48 interplanetary type IV bursts observed with the Radio and Plasma Wave Investigation (WAVES) instrument onboard Wind in the 13.825 MHz - 20 kHz frequency range. The dynamic spectra of the Radio Solar Telescope Network (RSTN), the Nançay Decametric Array (DAM), the Appareil de Routine pour le Traitement et l' Enregistrement Magnetique de l' Information Spectral (ARTEMIS-IV), the Culgoora, Hiraso, and the Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation (IZMIRAN) Radio Spectrographs were used to track the evolution of the events in the low corona. These were supplemented with soft X-ray (SXR) flux-measurements from the Geostationary Operational Environmental Satellite (GOES) and coronal mass ejections (CME) data from the Large Angle and Spectroscopic Coronagraph (LASCO) onboard the Solar and Heliospheric Observatory (SOHO). Positional information of the coronal bursts was obtained by the Nançay Radioheliograph (NRH). We examined the relationship of the type IV events with coronal radio bursts, CMEs, and SXR flares. The majority of the events (45) were characterized as compact, their duration was on average 106 minutes. This type of events was, mostly, associated with M- and X-class flares (40 out of 45) and fast CMEs, 32 of these events had CMEs faster than 1000 km s^{-1}. Furthermore, in 43 compact events the CME was possibly subjected to reduced aerodynamic drag as it was propagating in the wake of a previous CME. A minority (three) of long-lived type {IV}_{{IP}} bursts was detected, with durations from 960 minutes to 115 hours. These events are referred to as extended or long duration and appear to replenish their energetic electron content, possibly from electrons escaping from the corresponding coronal
MBARI CANON Experiment Visualization and Analysis
NASA Astrophysics Data System (ADS)
Fatland, R.; Oscar, N.; Ryan, J. P.; Bellingham, J. G.
2013-12-01
We describe the task of understanding a marine drift experiment conducted by MBARI in Fall 2012 ('CANON'). Datasets were aggregated from a drifting ADCP, from the MBARI Environmental Sample Processor, from Long Range Autonomous Underwater Vehicles (LRAUVs), from other in situ sensors, from NASA and NOAA remote sensing platforms, from moorings, from shipboard CTD casts and from post-experiment metagenomic analysis. We seek to combine existing approaches to data synthesis -- visual inspection, cross correlation and co.-- with three new ideas. This approach has the purpose of differentiating biological signals into three causal categories: Microcurrent advection, physical factors and microbe metabolism. Respective examples are aberrance from Lagrangian frame drift due to windage, changes in solar flux over several days, and microbial population responses to shifts in nitrate concentration. The three ideas we implemented are as follows: First, we advect LRAUV data to look for patterns in time series data for conserved quanitities such as salinity. We investigate whether such patterns can be used to support or undermine the premise of Lagrangian motion of the experiment ensemble. Second we built a set of configurable filters that enable us to visually isolate segments of data: By type, value, time, anomaly and location. Third we associated data hypotheses with a Bayesian inferrence engine for the purpose of model validation, again across sections taken from within the complete data complex. The end result is towards a free-form exploration of experimental data with low latency: from question to view, from hypothesis to test (albeit with considerable preparatory effort.) Preliminary results show the three causal categories shifting in relative influence.
Canonical and Non-Canonical Barriers Facing AntimiR Cancer Therapeutics
Cheng, Christopher J.; Saltzman, W. Mark; Slack, Frank J.
2013-01-01
Once considered genetic “oddities”, microRNAs (miRNAs) are now recognized as key epigenetic regulators of numerous biological processes, including some with a causal link to the pathogenesis, maintenance, and treatment of cancer. The crux of small RNA-based therapeutics lies in the antagonism of potent cellular targets; the main shortcoming of the field in general, lies in ineffective delivery. Inhibition of oncogenic miRNAs is a relatively nascent therapeutic concept, but as with predecessor RNA-based therapies, success hinges on delivery efficacy. This review will describe the canonical (e.g. pharmacokinetics and clearance, cellular uptake, endosome escape, etc.) and non-canonical (e.g. spatial localization and accessibility of miRNA, technical limitations of miRNA inhibition, off-target impacts, etc.) challenges to the delivery of antisense-based anti-miRNA therapeutics (i.e. antimiRs) for the treatment of cancer. Emphasis will be placed on how the current leading antimiR platforms—ranging from naked chemically modified oligonucleotides to nanoscale delivery vehicles—are affected by and overcome these barriers. The perplexity of antimiR delivery presents both engineering and biological hurdles that must be overcome in order to capitalize on the extensive pharmacological benefits of antagonizing tumor-associated miRNAs PMID:23745563
Canonical Approaches to Applications of the Virial Theorem.
Walton, Jay R; Rivera-Rivera, Luis A; Lucchese, Robert R; Bevan, John W
2016-02-11
Canonical approaches are applied for investigation of the extraordinarily accurate electronic ground state potentials of H2(+), H2, HeH(+), and LiH using the virial theorem. These approaches will be dependent on previous investigations involving the canonical nature of E(R), the Born-Oppenheimer potential, and F(R), the associated force of E(R), that have been demonstrated to be individually canonical to high accuracy in the case of the systems investigated. Now, the canonical nature of the remaining functions in the virial theorem [the electronic kinetic energy T(R), the electrostatic potential energy V(R), and the function W(R) = RF(R)] are investigated and applied to H2, HeH(+), and LiH with H2(+) chosen as reference. The results will be discussed in the context of a different perspective of molecular bonding that goes beyond previous direct applications of the virial theorem. PMID:26788937
On the control of a canonical separated flow
NASA Astrophysics Data System (ADS)
Griffin, John C.
Flow separation is generally an undesirable phenomenon that produces adverse effects to ideal aerodynamic performance. Control of ow separation is a complex problem and thus a popular area of research. A common obstacle is the lack of understanding of the complex fluid mechanics in cases of ow separation, evident by the substantial amount of ow control achieved through trial-and-error methods. The purpose of this work is to better understand the nature of separation for improved active control methods, which includes closed-loop control via reduced order methods. Control of a canonical separation problem, with the key features of separated flow, is achieved at a chord Reynolds number of 105. Separation is created on a at plate model, void of curvature that would otherwise include effects particular to the type of aerodynamic body. The characteristics of the imposed separation are evaluated with the intent of having a nominally two-dimensional separation, with the same essential flow characteristics of a more traditionally stalled airfoil. Results provide a reduced-order estimation technique that is used to identify global, dynamic modes through experimental measurements. Reattachment of the baseline separation is first achieved in open-loop control via ZNMF actuation. Efficient reattachment is reached by targeting the identified characteristic flow frequencies, which is able to reattach the separated flow with less than a quarter of the control effort as a comparison case with high-frequency forcing. The baseline and control results are used to identify a reduced-order model suitable for closed-loop control, with benefits of set-point tracking and full boundary layer attachment with minimum control effort.
Canonical solutions for unsteady flow fields. M.S. Thesis - George Washington Univ.
NASA Technical Reports Server (NTRS)
Liu, G. C.
1984-01-01
The initial value problem of one-dimensional gas-dynamics involving discontinuous, nonuniform initial data is discussed. Canonical solutions which are valid in a small x, t region aroung a discontinuity, and which include the first order effects of nonuniformities in the data, are derived explicitly. The theory is derived by considering a group of elementary piston problems. Solutions with a shock or with a centered expansion wave are worked out individually in order to relate initial flow properties and their gradients to the speed and acceleration of the discontinuity waves. They are then combined to represent the solution of a general initial value problem by regarding the piston path as a contact line. In addition, problems with chemical reaction are discussed in terms of elementary piston problems which involve strong detonation waves, Chapman-Jouguet detonation waves, and deflagration waves.
Concepts of orthopedic disorders in Avicenna's Canon of Medicine.
Afshar, Ahmadreza
2011-03-01
This manuscript offers a brief review of the orthopedic subjects in the Canon of Medicine. Highlights include, but are not limited to, the anatomy of the musculoskeletal system, fractures and dislocations, nerve and tendon injuries, different types of wounds and ulcers, and bone infections. Some of the concepts regarding musculoskeletal disorders remain relevant to current orthopedic knowledge. Reviewing the orthopedic subjects in the Canon of Medicine reveals that Avicenna has made a significant contribution to the evolution of orthopedic knowledge. PMID:21361728
NASA Astrophysics Data System (ADS)
Zarrinkamar, S.; Hassanabadi, H.; Rajabi, A. A.
2013-03-01
The interior of both Schwarzschild and Kantowski-Sachs black holes is studied via a non-canonical noncommutative extension of the Wheeler-DeWitt equation in the interesting work (Bastos et al. in Phys. Rev. D 84:024005, 2011) by neglecting the cubic and quartic terms arising the Hamiltonian. Here, we consider the problem when these terms are present and provide a more realistic analytical solution to the problem.
Non-Canonical Notch Signaling in Cancer and Immunity
Ayaz, Furkan; Osborne, Barbara A.
2014-01-01
Canonical Notch signaling is initiated by γ-secretase-mediated cleavage of the Notch receptor, leading to the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-Jκ, resulting in the activation of downstream target genes. While canonical Notch signaling is well known to play an active role in several steps during development as well in multiple cell fate decisions, recent evidence from both invertebrate and vertebrate systems indicates that non-canonical, RBP-Jκ-independent signaling is important in several cellular processes including oncogenesis and activation of T lymphocytes. These observations raise the possibility that, through an understanding of non-canonical Notch signaling, novel strategies for inhibiting Notch signaling may prove useful in the design of therapies targeted to block aberrant Notch activity. In this mini-review, we will examine the current data demonstrating a non-canonical role for Notch signaling in both cancer and the immune system and suggest a better understanding of non-canonical signaling may reveal novel strategies to block Notch signaling in disease. PMID:25538890
Non-canonical generalizations of slow-roll inflation models
Tzirakis, Konstantinos; Kinney, William H. E-mail: whkinney@buffalo.edu
2009-01-15
We consider non-canonical generalizations of two classes of single-field inflation models. First, we study the non-canonical version of ''ultra-slow roll'' inflation, which is a class of inflation models for which quantum modes do not freeze at horizon crossing, but instead evolve rapidly on superhorizon scales. Second, we consider the non-canonical generalization of the simplest ''chaotic'' inflation scenario, with a potential dominated by a quadratic (mass) term for the inflaton. We find a class of related non-canonical solutions with polynomial potentials, but with varying speed of sound. These solutions are characterized by a constant field velocity, and we dub such models isokinetic inflation. As in the canonical limit, isokinetic inflation has a slightly red-tilted power spectrum, consistent with current data. Unlike the canonical case, however, these models can have an arbitrarily small tensor/scalar ratio. Of particular interest is that isokinetic inflation is marked by a correlation between the tensor/scalar ratio and the amplitude of non-Gaussianity such that parameter regimes with small tensor/scalar ratio have large associated non-Gaussianity, which is a distinct observational signature.
Distinguishing k-defects from their canonical twins
Andrews, Melinda; Lewandowski, Matt; Trodden, Mark; Wesley, Daniel
2010-11-15
We study k-defects--topological defects in theories with more than two derivatives and second-order equations of motion--and describe some striking ways in which these defects both resemble and differ from their analogues in canonical scalar field theories. We show that, for some models, the homotopy structure of the vacuum manifold is insufficient to establish the existence of k-defects, in contrast to the canonical case. These results also constrain certain families of Dirac-Born-Infeld instanton solutions in the 4-dimensional effective theory. We then describe a class of k-defect solutions, which we dub ''doppelgaengers,'' that precisely match the field profile and energy density of their canonical scalar field theory counterparts. We give a complete characterization of Lagrangians which admit doppelgaenger domain walls. By numerically computing the fluctuation eigenmodes about domain wall solutions, we find different spectra for doppelgaengers and canonical walls, allowing us to distinguish between k-defects and the canonical walls they mimic. We search for doppelgaengers for cosmic strings by numerically constructing solutions of Dirac-Born-Infeld and canonical scalar field theories. Despite investigating several examples, we are unable to find doppelgaenger cosmic strings, hence the existence of doppelgaengers for defects with codimension >1 remains an open question.
ERIC Educational Resources Information Center
Stifle, Jack
The PLATO IV computer-based instructional system consists of a large scale centrally located CDC 6400 computer and a large number of remote student terminals. This is a brief and general description of the proposed input/output hardware necessary to interface the student terminals with the computer's central processing unit (CPU) using available…
ERIC Educational Resources Information Center
Pondy, Dorothy, Comp.
The catalog was compiled to assist instructors in planning community college and university curricula using the 48 computer-assisted accountancy lessons available on PLATO IV (Programmed Logic for Automatic Teaching Operation) for first semester accounting courses. It contains information on lesson access, lists of acceptable abbreviations for…
IVS Technology Coordinator Report
NASA Technical Reports Server (NTRS)
Whitney, Alan
2013-01-01
This report of the Technology Coordinator includes the following: 1) continued work to implement the new VLBI2010 system, 2) the 1st International VLBI Technology Workshop, 3) a VLBI Digital- Backend Intercomparison Workshop, 4) DiFX software correlator development for geodetic VLBI, 5) a review of progress towards global VLBI standards, and 6) a welcome to new IVS Technology Coordinator Bill Petrachenko.
State analysis of nonlinear systems using local canonical variate analysis
Hunter, N.F.
1997-01-01
There are many instances in which time series measurements are used to derive an empirical model of a dynamical system. State space reconstruction from time series measurement has applications in many scientific and engineering disciplines including structural engineering, biology, chemistry, climatology, control theory, and physics. Prediction of future time series values from empirical models was attempted as early as 1927 by Yule, who applied linear prediction methods to the sunspot values. More recently, efforts in this area have centered on two related aspects of time series analysis, namely prediction and modeling. In prediction future time series values are estimated from past values, in modeling, fundamental characteristics of the state model underlying the measurements are estimated, such as dimension and eigenvalues. In either approach a measured time series, [{bold y}(t{sub i})], i= 1,... N is assumed to derive from the action of a smooth dynamical system, s(t+{bold {tau}})=a(s(t)), where the bold notation indicates the (potentially ) multivariate nature of the time series. The time series is assumed to derive from the state evolution via a measurement function c. {bold y}(t)=c(s(t)) In general the states s(t), the state evolution function a and the measurement function c are In unknown, and must be inferred from the time series measurements. We approach this problem from the standpoint of time series analysis. We review the principles of state space reconstruction. The specific model formulation used in the local canonical variate analysis algorithm and a detailed description of the state space reconstruction algorithm are included. The application of the algorithm to a single-degree-of- freedom Duffing-like Oscillator and the difficulties involved in reconstruction of an unmeasured degree of freedom in a four degree of freedom nonlinear oscillator are presented. The advantages and current limitations of state space reconstruction are summarized.
Gillers, Benjamin S; Chiplunkar, Aditi; Aly, Haytham; Valenta, Tomas; Basler, Konrad; Christoffels, Vincent M.; Efimov, Igor R; Boukens, Bastiaan J; Rentschler, Stacey
2014-01-01
Rationale Proper patterning of the atrioventricular canal (AVC) is essential for delay of electrical impulses between atria and ventricles, and defects in AVC maturation can result in congenital heart disease. Objective To determine the role of canonical Wnt signaling in the myocardium during AVC development. Methods and Results We utilized a novel allele of β-catenin that preserves β-catenin’s cell adhesive functions but disrupts canonical Wnt signaling, allowing us to probe the effects of Wnt loss of function independently. We show that loss of canonical Wnt signaling in the myocardium results in tricuspid atresia with hypoplastic right ventricle associated with loss of AVC myocardium. In contrast, ectopic activation of Wnt signaling was sufficient to induce formation of ectopic AV junction-like tissue as assessed by morphology, gene expression, and electrophysiologic criteria. Aberrant AVC development can lead to ventricular preexcitation, a characteristic feature of Wolff-Parkinson-White syndrome. We demonstrate that postnatal activation of Notch signaling downregulates canonical Wnt targets within the AV junction. Stabilization of β-catenin protein levels can rescue Notch-mediated ventricular preexcitation and dysregulated ion channel gene expression. Conclusions Our data demonstrate that myocardial canonical Wnt signaling is an important regulator of AVC maturation and electrical programming upstream of Tbx3. Our data further suggests that ventricular preexcitation may require both morphologic patterning defects, as well as myocardial lineage reprogramming, to allow robust conduction across accessory pathway tissue. PMID:25599332
Activation of the Canonical Wnt Signaling Pathway Induces Cementum Regeneration.
Han, Pingping; Ivanovski, Saso; Crawford, Ross; Xiao, Yin
2015-07-01
Canonical Wnt signaling is important in tooth development but it is unclear whether it can induce cementogenesis and promote the regeneration of periodontal tissues lost because of disease. Therefore, the aim of this study is to investigate the influence of canonical Wnt signaling enhancers on human periodontal ligament cell (hPDLCs) cementogenic differentiation in vitro and cementum repair in a rat periodontal defect model. Canonical Wnt signaling was induced by (1) local injection of lithium chloride; (2) local injection of sclerostin antibody; and (3) local injection of a lentiviral construct overexpressing β-catenin. The results showed that the local activation of canonical Wnt signaling resulted in significant new cellular cementum deposition and the formation of well-organized periodontal ligament fibers, which was absent in the control group. In vitro experiments using hPDLCs showed that the Wnt signaling pathway activators significantly increased mineralization, alkaline phosphatase (ALP) activity, and gene and protein expression of the bone and cementum markers osteocalcin (OCN), osteopontin (OPN), cementum protein 1 (CEMP1), and cementum attachment protein (CAP). Our results show that the activation of the canonical Wnt signaling pathway can induce in vivo cementum regeneration and in vitro cementogenic differentiation of hPDLCs. PMID:25556853
Canonical versus noncanonical equilibration dynamics of open quantum systems.
Yang, Chun-Jie; An, Jun-Hong; Luo, Hong-Gang; Li, Yading; Oh, C H
2014-08-01
In statistical mechanics, any quantum system in equilibrium with its weakly coupled reservoir is described by a canonical state at the same temperature as the reservoir. Here, by studying the equilibration dynamics of a harmonic oscillator interacting with a reservoir, we evaluate microscopically the condition under which the equilibration to a canonical state is valid. It is revealed that the non-Markovian effect and the availability of a stationary state of the total system play a profound role in the equilibration. In the Markovian limit, the conventional canonical state can be recovered. In the non-Markovian regime, when the stationary state is absent, the system equilibrates to a generalized canonical state at an effective temperature; whenever the stationary state is present, the equilibrium state of the system cannot be described by any canonical state anymore. Our finding of the physical condition on such noncanonical equilibration might have significant impact on statistical physics. A physical scheme based on circuit QED is proposed to test our results. PMID:25215704
Interference Mitigation Based on Intelligent Location Selection in a Canonical Communication Network
NASA Astrophysics Data System (ADS)
Qu, Junyue; Cai, Yueming; Zheng, Jianchao; Yang, Wendong; Yang, Weiwei; Hu, Yajie
2016-01-01
In this letter, the interference mitigation in a canonical communication network is discussed from the perspective of intelligent location selection. A potential game model is constructed and a location-selection algorithm is designed combining no-regret procedure. With the proposed algorithm, all nodes can update their strategies with limited information exchange. Specifically, our proposed algorithm can converge to a set of correlated equilibria which are the globally or locally optimal solution to the problem of interference minimization. Moreover, our proposed algorithm can achieve distributed implementation without a central node. Simulation results demonstrate that the total interference can be mitigated efficiently with our proposed algorithm. And the proposed algorithm can converge fast.
NASA Astrophysics Data System (ADS)
Lundquist, Charles A.
2009-12-01
The Sputnik IV launch occurred on May 15, 1960. On May 19, an attempt to deorbit a 'space cabin' failed and the cabin went into a higher orbit. The orbit of the cabin was monitored and Moonwatch volunteer satellite tracking teams were alerted to watch for the vehicle demise. On September 5, 1962, several team members from Milwaukee, Wisconsin made observations starting at 4:49 a.m. of a fireball following the predicted orbit of Sputnik IV. Requests went out to report any objects found under the fireball path. An early morning police patrol in Manitowoc had noticed a metal object on a street and had moved it to the curb. Later the officers recovered the object and had it dropped off at the Milwaukee Journal. The Moonwarch team got the object and reported the situation to Moonwatch Headquarters at the Smithsonian Astrophysical Observatory. A team member flew to Cambridge with the object. It was a solid, 9.49 kg piece of steel with a slag-like layer attached to it. Subsequent analyses showed that it contained radioactive nuclei produced by cosmic ray exposure in space. The scientists at the Observatory quickly recognized that measurements of its induced radioactivity could serve as a calibration for similar measurements of recently fallen nickel-iron meteorites. Concurrently, the Observatory directorate informed government agencies that a fragment from Sputnik IV had been recovered. Coincidently, a debate in the UN Committee on Peaceful Uses of Outer Space involved the issue of liability for damage caused by falling satellite fragments. On September 12, the Observatory delivered the bulk of the fragment to the US Delegation to the UN. Two days later, the fragment was used by US Ambassador Francis Plimpton as an exhibit that the time had come to agree on liability for damage from satellite debris. He offered the Sputnik IV fragment to USSR Ambassador P.D. Morozov, who refused the offer. On October 23, Drs. Alla Massevitch and E.K. Federov of the USSR visited the
Spatial updating in the great grand canonical ensemble
NASA Astrophysics Data System (ADS)
Orkoulas, G.; Noon, Daniel P.
2009-10-01
In spatial updating grand canonical Monte Carlo, particle transfers are implemented by examining the local environment around a point in space. In the present work, these algorithms are extended to very high densities by allowing the volume to fluctuate, thus forming a great grand canonical ensemble. Since fluctuations are unbounded, a constraint must be imposed. The constrained ensemble may be viewed as a superposition of either constant-pressure or grand canonical ensembles. Each simulation of the constrained ensemble requires a set of weights that must be determined iteratively. The outcome of a single simulation is the density of states in terms of all its independent variables. Since all extensive variables fluctuate, it is also possible to estimate absolute free energies and entropies from a single simulation. The method is tested on a system of hard spheres and the transition from the fluid to a face-centered cubic crystal is located with high precision.
Ohta, Sho; Wang, Baolin; Mansour, Suzanne L; Schoenwolf, Gary C
2016-06-15
The inner ear consists of two otocyst-derived, structurally and functionally distinct components: the dorsal vestibular and ventral auditory compartments. BMP signaling is required to form the vestibular compartment, but how it complements other required signaling molecules and acts intracellularly is unknown. Using spatially and temporally controlled delivery of signaling pathway regulators to developing chick otocysts, we show that BMP signaling regulates the expression of Dlx5 and Hmx3, both of which encode transcription factors essential for vestibular formation. However, although BMP regulates Dlx5 through the canonical SMAD pathway, surprisingly, it regulates Hmx3 through a non-canonical pathway involving both an increase in cAMP-dependent protein kinase A activity and the GLI3R to GLI3A ratio. Thus, both canonical and non-canonical BMP signaling establish the precise spatiotemporal expression of Dlx5 and Hmx3 during dorsal vestibular development. The identification of the non-canonical pathway suggests an intersection point between BMP and SHH signaling, which is required for ventral auditory development. PMID:27151948
Accretion of the Moon from non-canonical discs.
Salmon, J; Canup, R M
2014-09-13
Impacts that leave the Earth-Moon system with a large excess in angular momentum have recently been advocated as a means of generating a protolunar disc with a composition that is nearly identical to that of the Earth's mantle. We here investigate the accretion of the Moon from discs generated by such 'non-canonical' impacts, which are typically more compact than discs produced by canonical impacts and have a higher fraction of their mass initially located inside the Roche limit. Our model predicts a similar overall accretional history for both canonical and non-canonical discs, with the Moon forming in three consecutive steps over hundreds of years. However, we find that, to yield a lunar-mass Moon, the more compact non-canonical discs must initially be more massive than implied by prior estimates, and only a few of the discs produced by impact simulations to date appear to meet this condition. Non-canonical impacts require that capture of the Moon into the evection resonance with the Sun reduced the Earth-Moon angular momentum by a factor of 2 or more. We find that the Moon's semi-major axis at the end of its accretion is approximately 7R⊕, which is comparable to the location of the evection resonance for a post-impact Earth with a 2.5 h rotation period in the absence of a disc. Thus, the dynamics of the Moon's assembly may directly affect its ability to be captured into the resonance. PMID:25114307
Noncommutative Black Holes and the Singularity Problem
NASA Astrophysics Data System (ADS)
Bastos, C.; Bertolami, O.; Dias, N. C.; Prata, J. N.
2011-09-01
A phase-space noncommutativity in the context of a Kantowski-Sachs cosmological model is considered to study the interior of a Schwarzschild black hole. Due to the divergence of the probability of finding the black hole at the singularity from a canonical noncommutativity, one considers a non-canonical noncommutativity. It is shown that this more involved type of noncommutativity removes the problem of the singularity in a Schwarzschild black hole.
Canonical representations of the Lie superalgebra osp(1,4)
NASA Astrophysics Data System (ADS)
Blank, J.; Havlíček, M.; Bednář, M.; Lassner, W.
1981-11-01
The method for constructing infinite-dimensional representations of Lie superalgebras proposed by the authors recently is applied to the superalgebra osp (1, 4). Explicit formulae for its generators in terms of two or three pairs of operators fulfilling the canonical commutation relations, at most one pair of operators fulfilling the canonical anticommutation relations and at most one real parameter are obtained. The generators of the Lie subalgebra sp (4, ℝ) ⊂ osp (1,4) are represented skew-symmetrically and both the Casimir operators are equal to multiples of the unity operator.
Twist-4 effects in electroproduction: Canonical operators and coefficient functions
NASA Astrophysics Data System (ADS)
Jaffe, R. L.; Soldate, M.
1982-07-01
The interpretation of observed scaling violations in leptoproduction is complicated by the possible presence of significant higher-twist effects. We refine the machinery of the operator-product expansion sufficiently for a study of twist-4 effects. In particular, we introduce and review the advantages of a special, "canonical" basis. We demonstrate that the canonical basis is adequate for the necessary twist-4 perturbative calculations, and calculate the operators' tree-level coefficient functions in electroproduction. Our results establish a framework within which careful analysis of more accurate data can provide information regarding correlations among the constituents of the proton.
Analytical satellite theories based on a new set of canonical elements
NASA Technical Reports Server (NTRS)
Scheifele, G.; Graf, O.
1974-01-01
A new analytical satellite theory is presented. Instead of the 6 classical elements of Delaunay, a set of 8 canonical elements is used. Whereas the time is the independent variable in classical theory, the true anomaly is the independent variable in the new theory. The new approach has four features: (1) The amount of formulas in the solution is reduced considerably. (2) The first order results are almost as accurate as second order results in classical theory. (3) The theory is easier to understand from a didactical point of view. (4) The problems connected with the inaccuracy of the mean motion that are typical for classical satellite theory are no longer present. The new elements are applied to analytical solutions of the zonal oblateness problem and to the problem of the 24 hour satellite.
NASA Technical Reports Server (NTRS)
Tornatore, Vincenza
2013-01-01
The main activities carried out at the PMD (Politecnico di Milano DIIAR) IVS Analysis Center during 2012 are briefly higlighted, and future plans for 2013 are sketched out. We principally continued to process European VLBI sessions using different approaches to evaluate possible differences due to various processing choices. Then VLBI solutions were also compared to the GPS ones as well as the ones calculated at co-located sites. Concerning the observational aspect, several tests were performed to identify the most suitable method to achieve the highest possible accuracy in the determination of GNSS (GLOBAL NAVIGATION SATELLITE SYSTEM) satellite positions using the VLBI technique.
Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-11
... Energy Regulatory Commission CSOLAR IV South, LLC, Wistaria Ranch Solar, LLC, CSOLAR IV West, LLC, CSOLAR IV North, LLC v. California Independent System Operator Corporation; Notice of Complaint Take notice... IV South, LLC, Wistaria Ranch Solar, LLC, CSOLAR IV West, LLC and CSOLAR IV North, LLC...
Canonical structure of higher derivative gravity in 3D
Guellue, Ibrahim; Sisman, Tahsin Cagri; Tekin, Bayram
2010-05-15
We give an explicitly gauge-invariant canonical analysis of linearized quadratic gravity theories in three dimensions for both flat and de Sitter backgrounds. In flat backgrounds, we also study the effects of the gravitational Chern-Simons term, include the sources, and compute the weak field limit as well as scattering between spinning massive particles.
Canonical Correlation Analysis that Incorporates Measurement and Sampling Error Considerations.
ERIC Educational Resources Information Center
Thompson, Bruce; Daniel, Larry
Multivariate methods are being used with increasing frequency in educational research because these methods control "experimentwise" error rate inflation, and because the methods best honor the nature of the reality to which the researcher wishes to generalize. This paper: explains the basic logic of canonical analysis; illustrates that canonical…
Uncertainty relations, zero point energy and the linear canonical group
NASA Technical Reports Server (NTRS)
Sudarshan, E. C. G.
1993-01-01
The close relationship between the zero point energy, the uncertainty relations, coherent states, squeezed states, and correlated states for one mode is investigated. This group-theoretic perspective enables the parametrization and identification of their multimode generalization. In particular the generalized Schroedinger-Robertson uncertainty relations are analyzed. An elementary method of determining the canonical structure of the generalized correlated states is presented.
Reputation, Canon-Formation, Pedagogy: George Orwell in the Classroom.
ERIC Educational Resources Information Center
Rodden, John
1991-01-01
Investigates the process by which books become canonized in British and U.S. schools and universities. Uses the case of George Orwell to examine the institutional and historical factors which condition the inclusion and exclusion of writer's work in Anglo-American classrooms. (SR)
Universal critical wrapping probabilities in the canonical ensemble
NASA Astrophysics Data System (ADS)
Hu, Hao; Deng, Youjin
2015-09-01
Universal dimensionless quantities, such as Binder ratios and wrapping probabilities, play an important role in the study of critical phenomena. We study the finite-size scaling behavior of the wrapping probability for the Potts model in the random-cluster representation, under the constraint that the total number of occupied bonds is fixed, so that the canonical ensemble applies. We derive that, in the limit L → ∞, the critical values of the wrapping probability are different from those of the unconstrained model, i.e. the model in the grand-canonical ensemble, but still universal, for systems with 2yt - d > 0 where yt = 1 / ν is the thermal renormalization exponent and d is the spatial dimension. Similar modifications apply to other dimensionless quantities, such as Binder ratios. For systems with 2yt - d ≤ 0, these quantities share same critical universal values in the two ensembles. It is also derived that new finite-size corrections are induced. These findings apply more generally to systems in the canonical ensemble, e.g. the dilute Potts model with a fixed total number of vacancies. Finally, we formulate an efficient cluster-type algorithm for the canonical ensemble, and confirm these predictions by extensive simulations.
37 CFR 10.20 - Canons and Disciplinary Rules.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Canons and Disciplinary Rules. 10.20 Section 10.20 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE REPRESENTATION OF OTHERS BEFORE THE PATENT AND TRADEMARK OFFICE Patent and...
Courtroom Access: Clarification and Recommendation for Canon 35.
ERIC Educational Resources Information Center
Forston, Robert F.; Forston, Anne L.
Canon 35, concerning improper publicizing of court proceedings, is one of the professional codes of the American Bar Association. First adopted in 1937, it has twice been amended and is widely observed by most courts throughout the United States. Reasons for barring radio or television coverage of trials are based on concerns that broadcasting…
Canonical orbital elements in terms of an arbitrary independent variable
NASA Technical Reports Server (NTRS)
Bond, V. R.; Janin, G.
1981-01-01
Within the framework of the Hamiltonian mechanics in the extended phase space, a set of canonical elements of the Delaunay type is developed in terms of an arbitary independent angular variable. Application to the four classical anomalies - eccentric, true, elliptic, and mean - is presented. Particular attention is given to the generalized time equation and its conjugate energy equation.
Canonical structure of the E10 model and supersymmetry
NASA Astrophysics Data System (ADS)
Kleinschmidt, Axel; Nicolai, Hermann; Chidambaram, Nitin K.
2015-04-01
A coset model based on the hyperbolic Kac-Moody algebra E10 has been conjectured to underlie 11-dimensional supergravity and M theory. In this note we study the canonical structure of the bosonic model for finite- and infinite-dimensional groups. In the case of finite-dimensional groups like G L (n ) we exhibit a convenient set of variables with Borel-type canonical brackets. The generalization to the Kac-Moody case requires a proper treatment of the imaginary roots that remains elusive. As a second result, we show that the supersymmetry constraint of D =11 supergravity can be rewritten in a suggestive way using E10 algebra data. Combined with the canonical structure, this rewriting explains the previously observed association of the canonical constraints with null roots of E10. We also exhibit a basic incompatibility between local supersymmetry and the K (E10) "R symmetry" that can be traced back to the presence of imaginary roots and to the unfaithfulness of the spinor representations occurring in the present formulation of the E10 worldline model, and that may require a novel type of bosonization/fermionization for its resolution. This appears to be a key challenge for future progress with E10.
An Alternative Method to Predict Performance: Canonical Redundancy Analysis.
ERIC Educational Resources Information Center
Dawson-Saunders, Beth; Doolen, Deane R.
1981-01-01
The relationships between predictors of performance and subsequent measures of clinical performance in medical school were examined for two classes at Southern Illinois University of Medicine. Canonical redundancy analysis was used to evaluate the association between six academic and three biographical preselection characteristics and four…
Connecting the Canon to Current Young Adult Literature
ERIC Educational Resources Information Center
Rybakova, Katie; Roccanti, Rikki
2016-01-01
In this article we discuss the respective roles of young adult literature and literary texts in the secondary level English Language Arts classroom and explore the connections that can be made between popular young adult books and the traditional canon. We provide examples showing how young adult literature bestsellers such as "The Book…
Catechistic Teaching, National Canons, and the Regimentation of Students' Voice
ERIC Educational Resources Information Center
Kroon, Sjaak
2013-01-01
Drawing on key incident analysis of classroom transcripts from Bashkortostan, France, North Korea, and Suriname, this article discusses the relationship between an increasingly canonical content of education and the discursive organization of teaching processes at the expense of both teachers' and students' voice. It argues that canonical…
Analysing Education Production in Malaysia Using Canonical Correlation Analysis
ERIC Educational Resources Information Center
Ismail, Noor Azina; Cheng, Ang Guat
2005-01-01
Data from the Third International Mathematics and Science Study carried out in 1999 and canonical correlation analysis were used to investigate the effects of school inputs, environmental inputs and gender influence in the production of a joint educational production function in mathematics and science subjects for eighth grade students in…
Improving the sampling efficiency of the Grand Canonical Simulated Quenching approach
Perez, Danny; Vernon, Louis J.
2012-04-04
attempted to equilibrate the chemical potential between two cells and hence allow for the calculation of coexistence curves, exploit the same idea: particle insertion (or exchange) is attempted and accepted with a Metropolis-like rule that depends exponentially on the energy change upon insertion. A well known limitation of this kind of approach is that the probability of accepting such a move decreases extremely rapidly with increasing density, due to the extremely large short-range repulsion between atoms. In response to these difficulties it became apparent that a solution to the problem might be to avoid abrupt insertions but instead to proceed gradually, so as to allow the system to react and make way for the incoming particle. In this view of things, the 'occupation' of a certain atomic site can be viewed as a continuous variable, ranging between 0 and 1, representing 'how much' of the particle is present at any given time. These ideas proved ideal in Molecular Dynamics (MD) settings because equations of motions for these occupation variables can sometimes be obtained. For example, in the case of Grand Canonical Molecular Dynamics [Cagin91], one special particle is allowed to have a fractional occupation. This can lead to either its destruction (occupation = 0) or its complex creation (occupation = 1) so as to enforce a given chemical potential. These approaches proved useful, but mostly in the liquid state where the probability of successfully inserting a new particle is sufficiently high. At higher densities, convergence proved to be hampered by very inefficient sampling. In this work, we explore the use of a related MD-based grand canonical technique, the Grand Canonical Simulated Quenching (GCSQ) of Phillpot and Rickman [Phillpot92,Phillpot94], and explore its application to the grand canonical sampling of solid state systems. We show that, in conjunction with advanced sampling techniques, GCSQ can be a useful tool to sample conformations of complex systems, such
Identification of canonical neural events during continuous gameplay of an 8-bit style video game.
Cavanagh, James F; Castellanos, Joel
2016-06-01
Cognitive neuroscience suffers from a unique and pervasive problem of generalizability. Since neural findings are often interpreted in the context of a specific manipulation during a carefully controlled task, it is hard to transfer knowledge from one task to another. In this report we address problems of generalizability with two methodological advancements. First, we aimed to transcend status quo experimental procedures with a continuous, engaging task environment. To this end, we created a novel 8-bit style continuous space shooter video game that elicits a multitude of goal-oriented events, such as crashing into a wall or blowing up an enemy with a missile. Second, we aimed to objectively define the psychological significance of these events. To achieve this aim, we used pattern classification of EEG data to derive predictive weights from carefully controlled pre-game exemplar events (oddball target detection and gambling wins and losses) and transferred those weights to EEG activities during video game events. All major goal-oriented events (crashes into the wall, crashes into an enemy, missile hit on an enemy) had a significant between-task transfer bias towards oddball target weights in the time range of the canonical P3, indicating the presence of similar salience detection processes. Missile hits on an enemy were specifically identified as gambling wins, confirming the hypothesis that this goal-oriented event was appetitive. These findings suggest that it is possible to identify the contribution of canonical neural activities during otherwise ambiguous and uncontrolled task performance. PMID:26952196
Canonical Acoustics and Its Application to Surface Acoustic Wave on Acoustic Metamaterials
NASA Astrophysics Data System (ADS)
Shen, Jian Qi
2016-08-01
In a conventional formalism of acoustics, acoustic pressure p and velocity field u are used for characterizing acoustic waves propagating inside elastic/acoustic materials. We shall treat some fundamental problems relevant to acoustic wave propagation alternatively by using canonical acoustics (a more concise and compact formalism of acoustic dynamics), in which an acoustic scalar potential and an acoustic vector potential (Φ ,V), instead of the conventional acoustic field quantities such as acoustic pressure and velocity field (p,u) for characterizing acoustic waves, have been defined as the fundamental variables. The canonical formalism of the acoustic energy-momentum tensor is derived in terms of the acoustic potentials. Both the acoustic Hamiltonian density and the acoustic Lagrangian density have been defined, and based on this formulation, the acoustic wave quantization in a fluid is also developed. Such a formalism of acoustic potentials is employed to the problem of negative-mass-density assisted surface acoustic wave that is a highly localized surface bound state (an eigenstate of the acoustic wave equations). Since such a surface acoustic wave can be strongly confined to an interface between an acoustic metamaterial (e.g., fluid-solid composite structures with a negative dynamical mass density) and an ordinary material (with a positive mass density), it will give rise to an effect of acoustic field enhancement on the acoustic interface, and would have potential applications in acoustic device design for acoustic wave control.
NASA Astrophysics Data System (ADS)
Zhong, Siyang; Zhang, Xin; Huang, Xun
2016-05-01
A new method, which can be effectively and efficiently applied in the simulations of broadband noise problems, is proposed for time domain impedance boundary condition implementations by using the so-called controllable canonical form that is well known in linear system. Usually, the impedance boundary condition can be defined in frequency domain as a rational polynomial function with poles in the negative half of the complex plane to guarantee stability; otherwise, causality might be violated in the corresponding time domain implementation. To address this issue, various methodologies have been proposed previously that usually lead to complicated polynomials, whose numerical implementations are often indirect and intricate. The proposed method with a controllable canonical form, on the other hand, directly transforms the frequency domain transfer function (a quotient of rational polynomials) to an equivalent state space model, which consists of a series of first-order ordinary differential equations that can be numerically implemented in a straightforward way. The proposed method is demonstrated by using two benchmark problems: a two-dimensional Gaussian pulse propagating in a uniform flow with a lined wall and the test cases from the NASA Langley grazing incidence tube experiments. Good agreements demonstrate the potential of the proposed computational method.
Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma
Razumilava, Nataliya; Gradilone, Sergio A.; Smoot, Rory L.; Mertens, Joachim C.; Bronk, Steven F.; Sirica, Alphonse E.; Gores, Gregory J.
2014-01-01
Background & Aims: The Hedgehog signaling pathway contributes to cholangiocarcinoma biology. However, canonical Hedgehog signaling requires cilia, and cholangiocarcinoma cells often do not express cilia. To resolve this paradox, we examined non-canonical (G-protein coupled, pertussis toxin sensitive) Hedgehog signaling in cholangiocarcinoma cells. Methods: Human [non-malignant (H69), malignant (HuCC-T1 and Mz-ChA-1)] and rat [non-malignant (BDE1 and NRC), and malignant (BDEneu)] cell lines were employed for this study. A BDEΔLoop2 cell line with the dominant-negative receptor Patched-1 was generated with the Sleeping Beauty transposon transfection system. Results: Cilia expression was readily identified in non-malignant, but not in malignant cholangiocarcinoma cell lines. Although the canonical Hh signaling pathway was markedly attenuated in cholangiocarcinoma cells, they were chemotactic to purmorphamine, a small-molecule direct Smoothened agonist. Purmorphamine also induced remodeling of the actin cytoskeleton with formation of filopodia and lamellipodia-like protrusions. All these biological features of cell migration were pertussis toxin sensitive, a feature of G-protein coupled (Gis) receptors. To further test the role of Hedgehog signaling in vivo, we employed a syngeneic orthotopic rat model of cholangiocarcinoma. In vivo, genetic inhibition of the Hedgehog signaling pathway employing BDEΔLoop2 cells or pharmacological inhibition with a small-molecule antagonist of Smoothened, vismodegib, was tumor and metastasis suppressive. Conclusions: Cholangiocarcinoma cells exhibit non-canonical Hedgehog signaling with chemotaxis despite impaired cilia expression. This non-canonical Hedgehog signaling pathway appears to contribute to cholangiocarcinoma progression, thereby, supporting a role for Hedgehog pathway inhibition in human cholangiocarcinoma. PMID:24239776
Accretion of the Moon from non-canonical discs
Salmon, J.; Canup, R. M
2014-01-01
Impacts that leave the Earth–Moon system with a large excess in angular momentum have recently been advocated as a means of generating a protolunar disc with a composition that is nearly identical to that of the Earth's mantle. We here investigate the accretion of the Moon from discs generated by such ‘non-canonical’ impacts, which are typically more compact than discs produced by canonical impacts and have a higher fraction of their mass initially located inside the Roche limit. Our model predicts a similar overall accretional history for both canonical and non-canonical discs, with the Moon forming in three consecutive steps over hundreds of years. However, we find that, to yield a lunar-mass Moon, the more compact non-canonical discs must initially be more massive than implied by prior estimates, and only a few of the discs produced by impact simulations to date appear to meet this condition. Non-canonical impacts require that capture of the Moon into the evection resonance with the Sun reduced the Earth–Moon angular momentum by a factor of 2 or more. We find that the Moon's semi-major axis at the end of its accretion is approximately 7R⊕, which is comparable to the location of the evection resonance for a post-impact Earth with a 2.5 h rotation period in the absence of a disc. Thus, the dynamics of the Moon's assembly may directly affect its ability to be captured into the resonance. PMID:25114307
Hord, M.
1982-01-01
The story of the Illiac IV is also in part the story of the Institute for Advanced Computation. This is the government organization formed in 1971 by the Defense Advanced Research Projects Agency and the National Aeronautics and Space Administration Ames Research Center to develop and operate this computer. The Institute provides access to the Illiac through a connection to the ARPANET, a national communication network. The Institute also performs software development, maintenance, and research in various advanced computation topics. Considerable effort has been invested by the Institute in documenting the evolution of the Illiac system and providing those publications to the user community. This material has experienced quite limited circulation and to most of the computer world the Illiac remains mysterious. This attitude is fostered by the lack of a thorough summary of the Illiac's environment, design and capabilities. It is in response to that information gap that this book is addressed.
NASA Technical Reports Server (NTRS)
Bremner, Paul G.; Vazquez, Gabriel; Christiano, Daniel J.; Trout, Dawn H.
2016-01-01
Prediction of the maximum expected electromagnetic pick-up of conductors inside a realistic shielding enclosure is an important canonical problem for system-level EMC design of space craft, launch vehicles, aircraft and automobiles. This paper introduces a simple statistical power balance model for prediction of the maximum expected current in a wire conductor inside an aperture enclosure. It calculates both the statistical mean and variance of the immission from the physical design parameters of the problem. Familiar probability density functions can then be used to predict the maximum expected immission for deign purposes. The statistical power balance model requires minimal EMC design information and solves orders of magnitude faster than existing numerical models, making it ultimately viable for scaled-up, full system-level modeling. Both experimental test results and full wave simulation results are used to validate the foundational model.
NASA Astrophysics Data System (ADS)
Lee, J. H.; Kevin; Monty, J. P.; Hutchins, N.
2016-08-01
The discrepancy between measured turbulence intensity obtained from experiments in wall-bounded turbulence and the fully resolved reference results (usually from DNS datasets) are often attributed to spatial resolution issues, especially in PIV measurements due to the presence of spatial averaging within the interrogation region/volume. In many cases, in particular at high Reynolds numbers (where there is a lack of DNS data), there is no attempt to verify that this is the case. There is a risk that attributing unexpected PIV statistics to spatial resolution, without careful checks, could mask wider problems with the experimental setup or test facility. Here, we propose a robust technique to validate the under-resolved PIV obtained turbulence intensity profiles for canonical wall-bounded turbulence. This validation scheme is independent of Reynolds number and does not rely on empirical functions. It is based on arguments that (1) the viscous-scaled small-scale turbulence energy is invariant with Reynolds number and that (2) the spatially under-resolved measurement is sufficient to capture the large-scale energy. This then suggests that we can estimate the missing energy from volume-filtered DNS data at much lower Reynolds numbers. Good agreement is found between the experimental results and estimation profiles for all three velocity components, demonstrating that the estimation tool successfully computes the missing energy for given spatial resolutions over a wide range of Reynolds numbers. A database for a canonical turbulent boundary layer and associated MATLAB function are provided that enable this missing energy to be calculated across a range of interrogation volume sizes, so that users do not require access to raw DNS data. This methodology and tool will provide PIV practitioners, investigating canonical wall-bounded turbulent flow with a convenient check of the effects of spatial resolution on a given experiment.
NASA Astrophysics Data System (ADS)
Husain, Viqar
2012-03-01
Research on quantum gravity from a non-perturbative 'quantization of geometry' perspective has been the focus of much research in the past two decades, due to the Ashtekar-Barbero Hamiltonian formulation of general relativity. This approach provides an SU(2) gauge field as the canonical configuration variable; the analogy with Yang-Mills theory at the kinematical level opened up some research space to reformulate the old Wheeler-DeWitt program into what is now known as loop quantum gravity (LQG). The author is known for his work in the LQG approach to cosmology, which was the first application of this formalism that provided the possibility of exploring physical questions. Therefore the flavour of the book is naturally informed by this history. The book is based on a set of graduate-level lectures designed to impart a working knowledge of the canonical approach to gravitation. It is more of a textbook than a treatise, unlike three other recent books in this area by Kiefer [1], Rovelli [2] and Thiemann [3]. The style and choice of topics of these authors are quite different; Kiefer's book provides a broad overview of the path integral and canonical quantization methods from a historical perspective, whereas Rovelli's book focuses on philosophical and formalistic aspects of the problems of time and observables, and gives a development of spin-foam ideas. Thiemann's is much more a mathematical physics book, focusing entirely on the theory of representing constraint operators on a Hilbert space and charting a mathematical trajectory toward a physical Hilbert space for quantum gravity. The significant difference from these books is that Bojowald covers mainly classical topics until the very last chapter, which contains the only discussion of quantization. In its coverage of classical gravity, the book has some content overlap with Poisson's book [4], and with Ryan and Shepley's older work on relativistic cosmology [5]; for instance the contents of chapter five of the
Confirmatory Factor Analysis of the WAIS-IV/WMS-IV
ERIC Educational Resources Information Center
Holdnack, James A.; Zhou, Xiaobin; Larrabee, Glenn J.; Millis, Scott R.; Salthouse, Timothy A.
2011-01-01
The Wechsler Adult Intelligence Scale-fourth edition (WAIS-IV) and the Wechsler Memory Scale-fourth edition (WMS-IV) were co-developed to be used individually or as a combined battery of tests. The independent factor structure of each of the tests has been identified; however, the combined factor structure has yet to be determined. Confirmatory…
Visual Search for Object Orientation Can Be Modulated by Canonical Orientation
ERIC Educational Resources Information Center
Ballaz, Cecile; Boutsen, Luc; Peyrin, Carole; Humphreys, Glyn W.; Marendaz, Christian
2005-01-01
The authors studied the influence of canonical orientation on visual search for object orientation. Displays consisted of pictures of animals whose axis of elongation was either vertical or tilted in their canonical orientation. Target orientation could be either congruent or incongruent with the object's canonical orientation. In Experiment 1,…
Treason Our Text: Feminist Challenges to the Literary Canon. Working Paper No. 104.
ERIC Educational Resources Information Center
Robinson, Lillian S.
Designed to make readers more aware of the systematic neglect of women's experience in the traditional literary canon, the paper presents feminist alternatives to the male-dominated canon, an assessment of their impact on the standard canon, and a proposal for new directions for further work. Two suggested approaches for feminist criticism are (1)…
Memory, Literacy, and Invention: Reimagining the Canon of Memory for the Writing Classroom
ERIC Educational Resources Information Center
Ryan, Kathleen J.
2004-01-01
This article challenges the assumption that the canon of memory means memorization and transcription, and, as a result, has little relevance for the writing classroom. An examination of the canon's historical legacy and its relationships to literacy and invention open a space for redefining the canon of memory as "rememoried knowing." In brief,…
Memory as Muse: An Argument for a Reconsideration of Memory as a Canon of Rhetoric.
ERIC Educational Resources Information Center
Rider, Janine
Although memory was one of the five canons of classical rhetoric, the more contemporary, narrower definition of memory as the training of the mind to remember certain things has eliminated memory as a useful rhetorical canon. However, teachers of writing who do regard memory highly, can redefine memory to restore it as one of the canons of…
Quantum canonical ensemble and correlation femtoscopy at fixed multiplicities
NASA Astrophysics Data System (ADS)
Akkelin, S. V.; Sinyukov, Yu. M.
2016-07-01
Identical particle correlations at fixed multiplicity are considered by means of quantum canonical ensemble of finite systems. We calculate one-particle momentum spectra and two-particle Bose-Einstein correlation functions in the ideal gas by using a recurrence relation for the partition function. Within such a model we investigate the validity of the thermal Wick's theorem and its applicability for decomposition of the two-particle distribution function. The dependence of the Bose-Einstein correlation parameters on the average momentum of the particle pair is also investigated. Specifically, we present the analytical formulas that allow one to estimate the effect of suppressing the correlation functions in a finite canonical system. The results can be used for the femtoscopy analysis of the A +A and p +p collisions with selected (fixed) multiplicity.
Frat is dispensable for canonical Wnt signaling in mammals
van Amerongen, Renée; Nawijn, Martijn; Franca-Koh, Jonathan; Zevenhoven, John; van der Gulden, Hanneke; Jonkers, Jos; Berns, Anton
2005-01-01
Wnt-signal transduction through β-catenin is thought to require the inhibition of GSK3 by Frat/GBP. To investigate the role of Frat in mammalian development, we have generated mice with targeted mutations in all three murine Frat homologs. We show that Frat is normally expressed at sites of active Wnt signaling. Surprisingly, Frat-deficient mice do not display gross abnormalities. Moreover, canonical Wnt signaling in primary cells is unaffected by the loss of Frat. These studies show that Frat is not an essential component of the canonical Wnt pathway in higher organisms, despite the strict requirement of Frat/GBP for maternal Wnt signaling in Xenopus. PMID:15681612
The Canon Group's effort: working toward a merged model.
Friedman, C; Huff, S M; Hersh, W R; Pattison-Gordon, E; Cimino, J J
1995-01-01
OBJECTIVE: To develop a representational schema for clinical data for use in exchanging data and applications, using a collaborative approach. DESIGN: Representational models for clinical radiology were independently developed manually by several Canon Group members who had diverse application interests, using sample reports. These models were merged into one common model through an iterative process by means of workshops, meetings, and electronic mail. RESULTS: A core merged model for radiologic findings present in a set of reports that subsumed the models that were developed independently. CONCLUSIONS: The Canon Group's modeling effort focused on a collaborative approach to developing a representational schema for clinical concepts, using chest radiography reports as the initial experiment. This effort resulted in a core model that represents a consensus. Further efforts in modeling will extend the representational coverage and will also address issues such as scalability, automation, evaluation, and support of the collaborative effort. PMID:7895135
Orthogonal canonical forms for second-order systems
NASA Technical Reports Server (NTRS)
Williams, Trevor; Laub, Alan
1989-01-01
The authors prove that a linear second-order system with arbitrary damping cannot be reduced to Hessenberg-triangular form by means of orthogonal transformations, while this reduction is always possible for the modal damping commonly assumed for models of flexible structures. The type of canonical form obtainable by means of orthogonal transformations acting on a second-order system is heavily dependent on the type of damping considered. If the damping matrix is merely positive semi-definite symmetric, it is generally not possible to obtain a reduction to Hessenberg-triangular form, while this reduction is trivial for zero or Rayleigh damping. If damping is modal, however, as is commonly assumed in structural models, the reduction exists and is nontrivial. Furthermore, reduction to triangular second-order Schur form is always possible for such damping: this canonical form appears likely to have applications to second-order system theory.
Some reference formulas for the generating functions of canonical transformations
NASA Astrophysics Data System (ADS)
Anselmi, Damiano
2016-02-01
We study some properties of the canonical transformations in classical mechanics and quantum field theory and give a number of practical formulas concerning their generating functions. First, we give a diagrammatic formula for the perturbative expansion of the composition law around the identity map. Then we propose a standard way to express the generating function of a canonical transformation by means of a certain "componential" map, which obeys the Baker-Campbell-Hausdorff formula. We derive the diagrammatic interpretation of the componential map, work out its relation with the solution of the Hamilton-Jacobi equation and derive its time-ordered version. Finally, we generalize the results to the Batalin-Vilkovisky formalism, where the conjugate variables may have both bosonic and fermionic statistics, and describe applications to quantum field theory.
Thermodynamic Lower Bounds of Deviation from Instantaneous Canonical State
NASA Astrophysics Data System (ADS)
Monnai, Takaaki
2016-04-01
We address the issue of the characterization of the nonequilibrium states for the time-dependent processes of a system interacting with a large reservoir, which is initially prepared in an equilibrium state. During the time evolution, we apply an external force to the system so that the actual density matrix is quantitatively different from the canonical state specified by the time-dependent system Hamiltonian. To express how the external forcing causes the deviation from equilibrium, we give a class of thermodynamic expressions for the lower bounds of the distance between the actual nonequilibrium state and the corresponding canonical state. The lower bounds are thermodynamically expressed only in terms of the strength of the forcing and its consequent entropy production rate.
NATIONAL COASTAL CONDITION REPORT IV
The National Coastal Condition Report IV (NCCR IV) is the fourth in a series of environmental assessments of U.S. coastal waters and the Great Lakes. The report includes assessments of all the nation’s estuaries in the contiguous 48 states and Puerto Rico, south-eastern Alaska, ...
Accretion of the Moon from non-canonical impacts
NASA Astrophysics Data System (ADS)
Salmon, Julien; Canup, R. M.
2013-10-01
The generally accepted scenario for the formation of the Moon involves the impact of a Mars-size object into the proto-Earth, resulting in the formation of a disk from which the Moon accretes (Cameron and Ward 1976). In a first paper (Salmon & Canup 2012), we showed that the disks resulting from these “canonical” impacts can lead to the accretion of a 1 lunar mass object on a timescale of order 10^2 yr. Recent works have focused on alternative impact configurations: bigger impactors (Canup 2012) or higher speed impacts into a fast spinning Earth (Cuk & Stewart 2012). These impacts leave the Earth-Moon system with an angular momentum about twice that in the current system. This quantity can be made consistent with its current value if the newly formed Moon is captured for a prolonged period in the evection resonance with the Sun (Cuk & Stewart 2012). The protolunar disks that are formed from these “non-canonical” impacts are generally more massive and more compact, containing a much greater fraction of their total disk mass in the Roche-interior portion of the disk, compared to canonical impacts. We have investigated the dynamics of the accretion of the Moon from such disks. While the overall accretion process is similar to that found from disks typical of canonical impacts, the more massive, compact disks typically produce a final moon with a much larger initial eccentricity, i.e. > 0.1 vs. 10^-3 to 10^-2 in canonical disks. Such high initial eccentricities may substantially reduce the probability of capture of the Moon into the evection resonance (e.g., Touma & Wisdom 1998), which is required to lower the angular momentum of the system in the non-canonical impacts. We will discuss which disk configurations can lead to the successful formation of the Moon, and how the Moon’s initial orbital properties vary for different impact scenarios.
Canonical quantization of the kink model beyond the static solution
Kapustnikov, A.A.; Pashnev, A.; Pichugin, A.
1997-02-01
A new approach to the quantization of the relativistic kink model around the solitonic solution is developed on the grounds of the collective coordinates method. The corresponding effective action is proved to be the action of the nonminimal d=1+1 point particle with curvature. It is shown that upon canonical quantization this action yields the spectrum of the kink solution obtained first with the help of WKB quantization. {copyright} {ital 1997} {ital The American Physical Society}
Canonical Hamiltonian for an extended test body in curved spacetime: To quadratic order in spin
NASA Astrophysics Data System (ADS)
Vines, Justin; Kunst, Daniela; Steinhoff, Jan; Hinderer, Tanja
2016-03-01
We derive a Hamiltonian for an extended spinning test-body in a curved background spacetime, to quadratic order in the spin, in terms of three-dimensional position, momentum, and spin variables having canonical Poisson brackets. This requires a careful analysis of how changes of the spin supplementary condition are related to shifts of the body's representative worldline and transformations of the body's multipole moments, and we employ bitensor calculus for a precise framing of this analysis. We apply the result to the case of the Kerr spacetime and thereby compute an explicit canonical Hamiltonian for the test-body limit of the spinning two-body problem in general relativity, valid for generic orbits and spin orientations, to quadratic order in the test spin. This fully relativistic Hamiltonian is then expanded in post-Newtonian orders and in powers of the Kerr spin parameter, allowing comparisons with and extensions of the test-mass limits of available post-Newtonian results. Both the fully relativistic Hamiltonian and the results of its expansion can inform the construction of waveform models, especially effective-one-body models, for the analysis of gravitational waves from compact binaries.
Exact canonic eigenstates of the truncated Bogoliubov Hamiltonian in an interacting bosons gas
NASA Astrophysics Data System (ADS)
Ferrari, Loris
2016-09-01
In a gas of N weakly interacting bosons [1,2], a truncated canonic Hamiltonian Hc follows from dropping all the interaction terms between free bosons with momentum ℏk ≠ 0 . Bogoliubov Canonic Approximation (BCA) is a further manipulation, replacing the number operatorN˜in of free particles in k = 0 , with the total number N of bosons. BCA Hc transforms into a different Hamiltonian HBCA =∑k≠0 ɛ(k) Bk† Bk + const , where Bk† and Bk create/annihilate non interacting pseudoparticles. The problem of the exact eigenstates of the truncated Hamiltonian is completely solved in the thermodynamic limit (TL) for a special class of eigensolutions | S , k>c , denoted as 's-pseudobosons', with energies ES(k) and zero total momentum. Some preliminary results are given for the exact eigenstates (denoted as 'η-pseudobosons'), carrying a total momentum ηℏk (η = 1 , 2 , …) . A comparison is done with HBCA and with the Gross-Pitaevskii theory (GPT), showing that some differences between exact and BCA/GPT results persist even in the thermodynamic limit (TL). Finally, it is argued that the emission of η-pseudobosons, which is responsible for the dissipation á la Landau [3], could be significantly different from the usual picture, based on BCA pseudobosons.
Sadoughi, Farahnaz; Lotfnezhad Afshar, Hadi; Olfatbakhsh, Asiie; Mehrdad, Neda
2016-01-01
Background: Advances in treatment options of breast cancer and development of cancer research centers have necessitated the collection of many variables about breast cancer patients. Detection of important variables as predictors and outcomes among them, without applying an appropriate statistical method is a very challenging task. Because of recurrent nature of breast cancer occurring in different time intervals, there are usually more than one variable in the outcome set. For the prevention of this problem that causes multicollinearity, a statistical method named canonical correlation analysis (CCA) is a good solution. Objectives: The purpose of this study was to analyze the data related to breast cancer recurrence of Iranian females using the CCA method to determine important risk factors. Patients and Methods: In this cross-sectional study, data of 584 female patients (mean age of 45.9 years) referred to Breast Cancer Research Center (Tehran, Iran) were analyzed anonymously. SPSS and NORM softwares (2.03) were used for data transformation, running and interpretation of CCA and replacing missing values, respectively. Data were obtained from Breast Cancer Research Center, Tehran, Iran. Results: Analysis showed seven important predictors resulting in breast cancer recurrence in different time periods. Family history and loco-regional recurrence more than 5 years after diagnosis were the most important variables among predictors and outcomes sets, respectively. Conclusions: Canonical correlation analysis can be used as a useful tool for management and preparing of medical data for discovering of knowledge hidden in them. PMID:27231580
Canonical Hamiltonian for an extended test body in curved spacetime: To quadratic order in spin
NASA Astrophysics Data System (ADS)
Vines, Justin; Kunst, Daniela; Steinhoff, Jan; Hinderer, Tanja
2016-05-01
We derive a Hamiltonian for an extended spinning test body in a curved background spacetime, to quadratic order in the spin, in terms of three-dimensional position, momentum, and spin variables having canonical Poisson brackets. This requires a careful analysis of how changes of the spin supplementary condition are related to shifts of the body's representative worldline and transformations of the body's multipole moments, and we employ bitensor calculus for a precise framing of this analysis. We apply the result to the case of the Kerr spacetime and thereby compute an explicit canonical Hamiltonian for the test-body limit of the spinning two-body problem in general relativity, valid for generic orbits and spin orientations, to quadratic order in the test spin. This fully relativistic Hamiltonian is then expanded in post-Newtonian orders and in powers of the Kerr spin parameter, allowing comparisons with the test-mass limits of available post-Newtonian results. Both the fully relativistic Hamiltonian and the results of its expansion can inform the construction of waveform models, especially effective-one-body models, for the analysis of gravitational waves from compact binaries.
Canonical wnt signaling is required for commissural axon guidance
Avilés, Evelyn C.
2015-01-01
ABSTRACT Morphogens have been identified as guidance cues for postcrossing commissural axons in the spinal cord. Shh has a dual effect on postcrossing commissural axons: a direct repellent effect mediated by Hhip as a receptor, and an indirect effect by shaping a Wnt activity gradient. Wnts were shown to be attractants for postcrossing commissural axons in both chicken and mouse embryos. In mouse, the effects of Wnts on axon guidance were concluded to depend on the planar cell polarity (PCP) pathway. Canonical Wnt signaling was excluded based on the absence of axon guidance defects in mice lacking Lrp6 which is an obligatory coreceptor for Fzd in canonical Wnt signaling. In the loss‐of‐function studies reported here, we confirmed a role for the PCP pathway in postcrossing commissural axon guidance also in the chicken embryo. However, taking advantage of the precise temporal control of gene silencing provided by in ovo RNAi, we demonstrate that canonical Wnt signaling is also required for proper guidance of postcrossing commissural axons in the developing spinal cord. Thus, axon guidance does not seem to depend on any one of the classical Wnt signaling pathways but rather involve a network of Wnt receptors and downstream components. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 190–208, 2016 PMID:26014644
Mundy, Christina; Bello, Adebayo; Sgariglia, Federica; Koyama, Eiki; Pacifici, Maurizio
2016-05-01
Chondrogenesis subtends the development of most skeletal elements and involves mesenchymal cell condensations differentiating into growth plate chondrocytes that proliferate, undergo hypertrophy, and are replaced by bone. In the pediatric disorder Hereditary Multiple Exostoses, however, chondrogenesis occurs also at ectopic sites and causes formation of benign cartilaginous tumors--exostoses--near the growth plates. No treatment is currently available to prevent or reverse exostosis formation. Here, we asked whether chondrogenesis could be stopped by targeting the hedgehog pathway, one of its major regulators. Micromass cultures of limb mesenchymal cells were treated with increasing amounts of the hedgehog inhibitor HhAntag or vehicle. The drug effectively blocked chondrogenesis and did so in a dose-dependent manner as monitored by: alcian blue-positive cartilage nodule formation; gene expression of cartilage marker genes; and reporter activity in Gli1-LacZ cell cultures. HhAntag blocked chondrogenesis even when the cultures were co-treated with bone morphogenetic protein 2 (rhBMP-2), a strong pro-chondrogenic factor. Immunoblots showed that HhAntag action included modulation of canonical (pSmad1/5/8) and non-canonical (pp38) BMP signaling. In cultures co-treated with HhAntag plus rhBMP-2, there was a surprising strong up-regulation of pp38 levels. Implantation of rhBMP-2-coated beads near metacarpal elements in cultured forelimb explants induced formation of ectopic cartilage that however, was counteracted by HhAntag co-treatment. Collectively, our data indicate that HhAntag inhibits not only hedgehog signaling, but also modulates canonical and non-canonical BMP signaling and blocks basal and rhBMP2-stimulated chondrogenesis, thus representing a potentially powerful drug-based strategy to counter ectopic cartilage growth or induce its involution. PMID:26363135
Godlove, David C.; Maier, Alexander; Woodman, Geoffrey F.
2014-01-01
We investigated whether a frontal area that lacks granular layer IV, supplementary eye field, exhibits features of laminar circuitry similar to those observed in primary sensory areas. We report, for the first time, visually evoked local field potentials (LFPs) and spiking activity recorded simultaneously across all layers of agranular frontal cortex using linear electrode arrays. We calculated current source density from the LFPs and compared the laminar organization of evolving sinks to those reported in sensory areas. Simultaneous, transient synaptic current sinks appeared first in layers III and V followed by more prolonged current sinks in layers I/II and VI. We also found no variation of single- or multi-unit visual response latency across layers, and putative pyramidal neurons and interneurons displayed similar response latencies. Many units exhibited pronounced discharge suppression that was strongest in superficial relative to deep layers. Maximum discharge suppression also occurred later in superficial than in deep layers. These results are discussed in the context of the canonical cortical microcircuit model originally formulated to describe early sensory cortex. The data indicate that agranular cortex resembles sensory areas in certain respects, but the cortical microcircuit is modified in nontrivial ways. PMID:24719113
Brown, M Alex; Paulenova, Alena; Gelis, Artem V
2012-07-16
Aqueous complexation of Th(IV), U(IV), Np(IV), Pu(III/IV), and Ce(III/IV) with DTPA was studied by potentiometry, absorption spectrophotometry, and cyclic voltammetry at 1 M ionic strength and 25 °C. The stability constants for the 1:1 complex of each trivalent and tetravalent metal were calculated. From the potentiometric data, we report stability constant values for Ce(III)DTPA, Ce(III)HDTPA, and Th(IV)DTPA of log β(101) = 20.01 ± 0.02, log β(111) = 22.0 ± 0.2, and log β(101) = 29.6 ± 1, respectively. From the absorption spectrophotometry data, we report stability constant values for U(IV)DTPA, Np(IV)DTPA, and Pu(IV)DTPA of log β(101) = 31.8 ± 0.1, 32.3 ± 0.1, and 33.67 ± 0.02, respectively. From the cyclic voltammetry data, we report stability constant values for Ce(IV) and Pu(III) of log β(101) = 34.04 ± 0.04 and 20.58 ± 0.04, respectively. The values obtained in this work are compared and discussed with respect to the ionic radius of each cationic metal. PMID:22738207
Hesse, Morten
2005-01-01
Background Personality disorders are common in substance abusers. Self-report questionnaires that can aid in the assessment of personality disorders are commonly used in assessment, but are rarely validated. Methods The Danish DIP-Q as a measure of co-morbid personality disorders in substance abusers was validated through principal components factor analysis and canonical correlation analysis. A 4 components structure was constructed based on 238 protocols, representing antagonism, neuroticism, introversion and conscientiousness. The structure was compared with (a) a 4-factor solution from the DIP-Q in a sample of Swedish drug and alcohol abusers (N = 133), and (b) a consensus 4-components solution based on a meta-analysis of published correlation matrices of dimensional personality disorder scales. Results It was found that the 4-factor model of personality was congruent across the Danish and Swedish samples, and showed good congruence with the consensus model. A canonical correlation analysis was conducted on a subset of the Danish sample with staff ratings of pathology. Three factors that correlated highly between the two variable sets were found. These variables were highly similar to the three first factors from the principal components analysis, antagonism, neuroticism and introversion. Conclusion The findings support the validity of the DIP-Q as a measure of DSM-IV personality disorders in substance abusers. PMID:15910688
Stationary waves on nonlinear quantum graphs: General framework and canonical perturbation theory.
Gnutzmann, Sven; Waltner, Daniel
2016-03-01
In this paper we present a general framework for solving the stationary nonlinear Schrödinger equation (NLSE) on a network of one-dimensional wires modeled by a metric graph with suitable matching conditions at the vertices. A formal solution is given that expresses the wave function and its derivative at one end of an edge (wire) nonlinearly in terms of the values at the other end. For the cubic NLSE this nonlinear transfer operation can be expressed explicitly in terms of Jacobi elliptic functions. Its application reduces the problem of solving the corresponding set of coupled ordinary nonlinear differential equations to a finite set of nonlinear algebraic equations. For sufficiently small amplitudes we use canonical perturbation theory, which makes it possible to extract the leading nonlinear corrections over large distances. PMID:27078341
Stationary waves on nonlinear quantum graphs: General framework and canonical perturbation theory
NASA Astrophysics Data System (ADS)
Gnutzmann, Sven; Waltner, Daniel
2016-03-01
In this paper we present a general framework for solving the stationary nonlinear Schrödinger equation (NLSE) on a network of one-dimensional wires modeled by a metric graph with suitable matching conditions at the vertices. A formal solution is given that expresses the wave function and its derivative at one end of an edge (wire) nonlinearly in terms of the values at the other end. For the cubic NLSE this nonlinear transfer operation can be expressed explicitly in terms of Jacobi elliptic functions. Its application reduces the problem of solving the corresponding set of coupled ordinary nonlinear differential equations to a finite set of nonlinear algebraic equations. For sufficiently small amplitudes we use canonical perturbation theory, which makes it possible to extract the leading nonlinear corrections over large distances.