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Sample records for iz vodoema v-11

  1. Near-contact Binaries IZ Monocerotis and AR Draconis

    NASA Astrophysics Data System (ADS)

    Yang, Yuan-Gui; Dai, Hai-Feng; Zhou, Zheng; Li, Qun

    2016-05-01

    We present multi-color photometric observations for two neglected near-contact binaries, IZ Mon (P=0\\_\\_AMP\\_\\_fd;77980) and AR Dra (P=0\\_\\_AMP\\_\\_fd;67584). By the aid of the updated W-D analysis code, the photometric solutions were deduced from the multi-color light curves (LCs). IZ Mon is a semi-detached binary with a mass ratio of q=0.388(+/- 0.002), while AR Dra is a detached star with a mass ratio of q=0.652(+/- 0.002). The asymmetric LCs of IZ Mon were modeled by a hot spot on the secondary’s surface, which may be attributed to mass transfer from the primary. Based on all collected eclipse times for two systems, we constructed their timing residual curves. The orbital period for IZ Mon may be continuously decreasing at a rate of {dP}/{dt}=-2.06(+/- 0.04) {days} {{yr}}-1, which may result from mass and angular momentum loss from the central system. For AR Dra, there exists a cyclic variation with a period of {P}3=104.9(+/- 2.9) {yr} due to light-time orbit effect via the presence of the third body, whose mass is more than 0.28(+/- 0.02) {M}ȯ . Finally, two near-contact binaries, IZ Mon and AR Dra, will evolve into contact binaries.

  2. Radio evolution of supernova SN 2008iz in M 82

    NASA Astrophysics Data System (ADS)

    Kimani, N.; Sendlinger, K.; Brunthaler, A.; Menten, K. M.; Martí-Vidal, I.; Henkel, C.; Falcke, H.; Muxlow, T. W. B.; Beswick, R. J.; Bower, G. C.

    2016-08-01

    We report on multi-frequency Very Large Array (VLA) and Very Long Baseline Interferometry (VLBI) radio observations for a monitoring campaign of supernova SN 2008iz in the nearby irregular galaxy M 82. We fit two models to the data, a simple time power-law, S ∝ tβ, and a simplified Weiler model, yielding decline indices of β = -1.22 ± 0.07 (days 100-1500) and -1.41 ± 0.02 (days 76-2167), respectively. The late-time radio light-curve evolution shows flux-density flares at ~970 and ~1400 days that are a factor of ~2 and ~4 higher than the expected flux, respectively. The later flare, except for being brighter, does not show signs of decline at least from results examined so far (2014 January 23; day 2167). We derive the spectral index, α, S ∝ να for frequencies 1.4 to 43 GHz for SN 2008iz during the period from ~430 to 2167 days after the supernova explosion. The value of α shows no signs of evolution and remains steep ≈-1 throughout the period, unlike that of SN 1993J, which started flattening at ~day 970. From the 4.8 and 8.4 GHz VLBI images, the supernova expansion is seen to start with a shell-like structure that becomes increasingly more asymmetric, then breaks up in the later epochs, with bright structures dominating the southern part of the ring. This structural evolution differs significantly from SN 1993J, which remains circularly symmetric over 4000 days after the explosion. The VLBI 4.8 and 8.4 GHz images are used to derive a deceleration index, m, for SN 2008iz, of 0.86 ± 0.02, and the average expansion velocity between days 73 and 1400 as (12.1 ± 0.2) × 103 km s-1. From the energy equipartition between magnetic field and particles, we estimate the minimum total energy in relativistic particles and the magnetic fields during the supernova expansion and also find the magnetic field amplification factor for SN 2008iz to be in the range of 55-400. The VLBI images (FITS files) are only available at the CDS via anonymous ftp to http

  3. Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24.

    PubMed

    Bartonkova, Iveta; Grycova, Aneta; Dvorak, Zdenek

    2016-07-18

    Variety of xenobiotics, including therapeutically used vitamin D analogues or environmental and alimentary endocrine disruptors, may interfere with vitamin D receptor (VDR) signaling, with serious physiological or pathophysiological consequences. Therefore, it is of topical interest to have reliable and efficient in vitro screening tools for the identification of agonists and activators of human VDR. We present here two novel stably transfected human reporter cell lines allowing rapid, high-throughput, and selective identification of VDR agonists and activators. Human colon adenocarcinoma cells LS180 were stably transfected with reporter plasmids CYP24_minP-pNL2.1[Nluc/Hygro] (IZ-CYP24 cells contain the -326/-46 sequence from the human CYP24A1 promoter) or VDREI3_SV40-pNL2.1[Nluc/Hygro] (IZ-VDRE cells contain three copies of vitamin D response elements VDRE-I from the human CYP24A1 promoter). Both cell lines remained fully functional for over two months in the culture and also after cryopreservation. Luciferase inductions ranged from 10-fold to 25-fold (RLU 10(6)-10(7)) and from 30-fold to 80-fold (RLU 10(3)-10(4)) in IZ-VDRE and IZ-CYP24 cells, respectively. Time-course analyses revealed that detection of VDR activators is possible as soon as after 8 h of incubation. Cell lines were highly selective toward VDR agonists, displaying no cross-activation by retinoids, thyroids, and steroids. As a proof of concept, we used IZ-VDRE and IZ-CYP24 cells for profiling analogues of vitamin D, and intermediates in vitamin D2 and vitamin D3 metabolic pathways against VDR transcriptional activity. The data obtained revealed significant activation of VDR not only by obligatory ligands calcitriol and ergocalcitriol but also by their precursors and degradation products. PMID:27327272

  4. Hot Deformation Behavior of Beta Titanium Ti-13V-11Cr-3Al Alloy

    NASA Astrophysics Data System (ADS)

    Abbasi, Seyed Mehdi; Morakkabati, Maryam; Sheikhali, Amir Hossein; Momeni, Amir

    2014-10-01

    Hot compression tests were conducted on Ti-13V-11Cr-3Al beta-Ti alloy in the temperature range of 1203 K to 1353 K (930 °C to 1080 °C) and at strain rates between 0.001 and 1 s-1 The stress-strain curves showed pronounced yield point phenomena at high strain rates and low temperatures. The yield point elongation and flow stresses at the upper and lower yield points were related to the Zener-Hollomon parameter. It was found that dynamic recovery at low strain rates and dynamic recrystallization at high strain rates were the controlling mechanisms of microstructural evolution. The results also showed that strain rate had a stronger influence on the hot deformation behavior than temperature. The microstructural observations and constitutive analysis of flow stress data supported the change in the hot deformation behavior of the studied alloy varies with strain rate. For various applied strain rates, the activation energy for hot deformation was calculated in range of 199.5 to 361.7 kJ/mol. At low strain rates (0.001 and 0.01 s-1), the value of activation energy was very close to the activation energy for the diffusion of V, Cr, and Al in beta titanium. The higher value of activation energy for deformation at high strain rates (0.1 and 1 s-1) was attributed to the accumulation of dislocations and the tendency to initiate dynamic recrystallization.

  5. [Historical notes on Infectious Diseases Hospital Francisco Javier Muñiz in Buenos Aires, Argentina].

    PubMed

    Laval, Enrique

    2012-08-01

    The Infectious Diseases Hospital Francisco Javier Muñiz, Buenos Aires, Argentina, is the oldest in Latin America. It is over 100 years old and has a history worthy of pride. It became known as "Hospital of the pests" and was preceded by the old House of Insulation, which served as a quarantine station during epidemics of cholera, yellow fever and smallpox. The new House of Insulation, built in the neighborhood of Parque Patricios ("Barracks Hospital"), was renamed in 1904 in memory of Francisco Javier Muñiz, a former military doctor, naturalist and paleontologist. Its technical name is "Porteño Care Centre and National Reference Regional Infectious-Contagious Disease". It receives numerous national and foreign undergraduate and postgraduate students in its Departments of Infectious Diseases and Respiratory Diseases. PMID:23096553

  6. VizieR Online Data Catalog: BVR photometry of IZ Mon and AR Dra (Yang+, 2016)

    NASA Astrophysics Data System (ADS)

    Yang, Y.-G.; Dai, H.-F.; Zhou, Z.; Li, Q.

    2016-07-01

    CCD Photometry for IZ Mon and AR Dra, was acquired using the 60cm telescope and the 85cm telescope at the Xinglong station (XLs) of National Astronomical Observatories of China (NAOC). Two telescopes are equipped with the standard Johnson-Cousins UBVRcIc. filters. We then obtained the individual observations as heliocentric Julian dates and differential magnitude, which are listed in Table1. The complete light curves for IZ Mon were obtained on 2009 January 20, 22, 24, 25, and 26, and March 1, using the 85cm telescope. The exposure times are fixed to be 20, 15, and 15s for BVR bands, respectively. A total of 961, 960, and 959 effective images in BVR bands are obtained. Another primary eclipse for IZ Mon was monitored on 2011 January 17. AR Dra was observed on 2009 February 20, 25, 26, and 27, with the 65cm telescope. The typical exposure times are 50, 40 and 40s for BVR bands, which depend on the condition of weather. In total, we obtained 733, 728 and 356 images in B, V and R bands, respectively. (6 data files).

  7. 2MASS J18082002-5104378: The brightest (V = 11.9) ultra metal-poor star

    NASA Astrophysics Data System (ADS)

    Meléndez, Jorge; Placco, Vinicius M.; Tucci-Maia, Marcelo; Ramírez, Iván; Li, Ting S.; Perez, Gabriel

    2016-01-01

    Context. The most primitive metal-poor stars are important for studying the conditions of the early galaxy and are also relevant to big bang nucleosynthesis. Aims: Our objective is to find the brightest (V< 14) most metal-poor stars. Methods: Candidates were selected using a new method, which is based on the mismatch between spectral types derived from colors and observed spectral types. They were observed first at low resolution with EFOSC2 at the NTT to obtain an initial set of stellar parameters. The most promising candidate, 2MASS J18082002-5104378 (V = 11.9), was observed at high resolution (R = 50 000) with UVES at the VLT, and a standard abundance analysis was performed. Results: We found that 2MASS J18082002-5104378 is an ultra metal-poor star with stellar parameters Teff = 5440 K, log g = 3.0 dex, vt = 1.5 km s-1, [Fe/H] = -4.1 dex. The star has [C/Fe] < +0.9 in a 1D analysis, or [C/Fe] ≲ +0.5 if 3D effects are considered; its abundance pattern is typical of normal (non-CEMP) ultra metal-poor stars. Interestingly, the star has a binary companion. Conclusions: 2MASS J1808-5104 is the brightest (V = 11.9) metal-poor star of its category, and it could be studied further with even higher S/N spectroscopy to determine additional chemical abundances, thus providing important constraints to the early chemical evolution of our Galaxy. Based on observations obtained at the European Southern Observatory (ESO) Very Large Telescope (VLT, observing program 293.D-5036) and New Technology Telescope (NTT, observing programs 091.D-0292 and 092.D-0308).

  8. Evaluation of the range shifter model for proton pencil-beam scanning for the Eclipse v.11 treatment planning system.

    PubMed

    Matysiak, Witold; Yeung, Daniel; Slopsema, Roelf; Li, Zuofeng

    2016-01-01

    Existing proton therapy pencil-beam scanning (PBS) systems have limitations on the minimum range to which a patient can be treated. This limitation arises from practical considerations, such as beam current intensity, layer spacing, and delivery time. The range shifter (RS) - a slab of stopping material inserted between the nozzle and the patient - is used to reduce the residual range of the incident beam so that the treatment ranges can be extended to shallow depths. Accurate modeling of the RS allows one to calculate the beam spot size entering the patient, given the proton energy, for arbitrary positions and thicknesses of the RS in the beam path. The Eclipse version 11 (v11) treatment planning system (TPS) models RS-induced beam widening by incorporating the scattering properties of the RS material into the V-parameter. Monte Carlo simulations with Geant4 code and analytical calculations using the Fermi-Eyges (FE) theory with Highland approximation of multiple Coulomb scattering (MCS) were employed to calculate proton beam widening due to scattering in the RS. We demonstrated that both methods achieved consistent results and could be used as a benchmark for evaluating the Eclipse V-parameter model. In most cases, the V-parameter model correctly predicted the beam spot size after traversing the RS. However, Eclipse did not enforce the constraint for a nonnegative covariance matrix when fitting the spot sizes to derive the phase space parameters, which resulted in incorrect calculations under specific conditions. In addition, Eclipse v11 incorrectly imposed limits on the individual values of the phase space parameters, which could lead to incorrect spot size values in the air calculated for beams with spot sigmas <3.8 mm. Notably, the TPS supplier (Varian) and hardware vendor (Ion Beam Applications) inconsistently refer to the RS position, which may result in improper spot size calculations. PMID:27074461

  9. Subaqueous hot springs in Köyceǧiz Lake and Dalyan Channel (SW Turkey)

    NASA Astrophysics Data System (ADS)

    Avşar, Özgür; Avşar, Ulaş; Kurtuluş, Bedri; Arslan, Şebnem; Güleç, Nilgün

    2014-05-01

    The preliminary investigations within the scope of a subaqueous geothermal exploration project revealed a total of seven underwater hot springs in the Köyceǧiz Lake and through its outlet, namely Dalyan Channel. Within the scope of this project, horizontal temperature and electrical conductivity profiles of the lake water were obtained by using an YSI CTD probe along a dense survey grid. Any anomaly in the temperature and/or electrical conductivity profiles was inspected by scuba divers in detail, and water samples were taken from the explored hot springs by using a syringe type sampler. Four of these explored hot springs are located on the southern shore of Köyceǧiz Lake and the remaining ones are on the northern part of the Dalyan Channel. The temperature of the subaqueous hot springs range from 26.41 to 29.57 °C, which is slightly lower than the temperature range of the on-land hot springs in the region (i.e., 30-39 °C). Discovery of subaqueous hot springs and investigation of chemistry of these sources will lead a more comprehensive assessment of the hydrogeochemistry of the region.

  10. Response of lake water quality to wastewater inputs from land-based fish farm located on Yuvarlakçay Creek in Köyceğiz-Dalyan Specially Protected Area, Turkey.

    PubMed

    Taşeli, B K

    2009-10-01

    Köyceğiz Lake is located in the south-western part of Turkey. The area between the Köyceğiz Lake and the Mediterranean Sea is covered with four small lakes and several canals. The surroundings of the lake, canals and forests have a great potential as a reproduction areas for Mediterranean Sea turtles (Caretta caretta) and sheltering place for various animals. In the vicinity of this system there are agricultural areas and small settlements. In this region the most important economic activities are tourism and fisheries. However, the lake is currently threatened by pollution because of (1) non-point source pollution (agriculture); (2) point sources (land-based fish farms); (3) inefficient sewerage systems; (4) uncontrolled soil erosion in its drainage basin; (5) inappropriate flood control measures; and (6) channel traffic. This study evaluates the influence of its influent creeks namely Namnam and Yuvarlakçay Creek on the water quality of Köyceğiz Lake, mainly because the creeks are believed to be responsible for the major pollutant load reaching the lake. Accordingly, this study demonstrates (1) change in the water quality of Köyceğiz Lake from 2006 to 2007; (2) the water quality classification of the major influent creeks feeding Köyceğiz Lake; and (3) how land-based fish farm influences Yuvarlakçay Creek water quality in a Köyceğiz-Dalyan Specially Protected Area. PMID:18855110

  11. Earthquake-induced soft-sediment deformations and seismically amplified erosion rates recorded in varved sediments of Köyceğiz Lake (SW Turkey)

    NASA Astrophysics Data System (ADS)

    Avşar, Ulaş; Jónsson, Sigurjón; Avşar, Özgür; Schmidt, Sabine

    2016-06-01

    Earthquake-triggered landslides amplify erosion rates in catchments, i.e., catchment response (CR) to seismic shocks. In addition to historical eyewitness accounts of muddy rivers implying CRs after large earthquakes, several studies have quantitatively reported increased sediment concentrations in rivers after earthquakes. However, only a few paleolimnological studies could detect CRs within lacustrine sedimentary sequences as siliciclastic-enriched intercalations within background sedimentation. Since siliciclastic-enriched intercalations can easily be of nonseismic origin, their temporal correlation with nearby earthquakes is crucial to assign a seismic triggering mechanism. In most cases, either uncertainties in dating methods or the lack of recent seismic activity has prevented reliable temporal correlations, making the seismic origin of observed sedimentary events questionable. Here we attempt to remove this question mark by presenting sedimentary traces of CRs in the 370-year-long varved sequence of Köyceğiz Lake (SW Turkey) that we compare with estimated peak ground acceleration (PGA) values of several nearby earthquakes. We find that earthquakes exceeding estimated PGA values of ~20 cm/s2 can induce soft-sediment deformations, while CRs seem only to be triggered by PGA levels higher than 70 cm/s2. In Köyceğiz Lake, CRs produce Cr- and Ni-enriched sedimentation due to the seismically mobilized soils derived from ultramafic rocks in the catchment. Given the varve chronology, the residence time of the seismically mobilized material in the catchment is determined to be 5 to 10 years.

  12. STATS SRS v11.0

    SciTech Connect

    Piscotty, M A; Nazario, O L

    2007-06-20

    The objective of this project is the delivery of an application that will provide a unified, web-based system for collecting, verifying and analyzing the achievements for Laboratory employees. The application will enable individual Directorates to manage and report achievement record data for their employees using an LLNL standard web browser. In addition, cross directorate data reporting and analysis will be available for such organizations as LSTO and programmatic directorates. This system is intended to store reference data and metadata for employee achievements. Abstracts and entire publications will not be stored in this system.Directorates are expected to use this system at all levels of management in preparing for Annual Self-Assessments, peer reviews, LDRD reviews, work force reviews, performance appraisals, and requests from sponsors. This document represents the primary deliverable for the Requirements Definition stage of system development. As part of a successful Requirements Definition, this document provides the development staff, the project sponsor, and the user community with a clear understanding of the product's operational, data, and other requirements. With this understanding, the development staff will take the opportunity to refine estimates regarding the cost, schedule, and deliverables reflected in it.

  13. Cubit Mesh Generation Toolkit V11.1

    Energy Science and Technology Software Center (ESTSC)

    2009-03-25

    CUBIT prepares models to be used in computer-based simulation of real-world events. CUBIT is a full-featured software toolkit for robust generation of two- and three-dimensional finite element meshes (grids) and geometry preparation. Its main goal is to reduce the time to generate meshes, particularly large hex meshes of complicated, interlocking assemblies.

  14. Military Curricula for Vocational & Technical Education. Refrigeration & Air Conditioning Specialist, Blocks III-V, 11-7.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. National Center for Research in Vocational Education.

    This plan of instruction, study guides, and workbooks for a secondary-postsecondary-level course in refrigeration and air conditioning are one of a number of military-developed curriculum packages selected for adaptation to vocational instruction and curriculum development in a civilian setting. It is the second section of a three-part course (see…

  15. 76 FR 20835 - Amendment of VOR Federal Airways V-1, V-7, V-11 and V-20; Kona, HI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... flight inspection. DATES: The effective date of FR Doc. 2011-5078, published on March 10, 2011 (76 FR...: Background Airspace Docket No. 10-AWP-20, published in the Federal Register on March 10, 2011, (76 FR 13082...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034;...

  16. 76 FR 13082 - Amendment of VOR Federal Airways V-1, V-7, V-11 and V-20; Kona, HI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a regulatory..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation...-11 and V-20; Kona, HI AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule....

  17. Production of alcohol from Jerusalem artichoke for gasoline additive. Proucavanje mogucnosti proizvodnje alkohola iz topinambura kao dodatka u benzin

    SciTech Connect

    Pekic, B.; Kisgeci, J.

    1984-01-01

    Trials conducted in 1980 and 1981 on three soil types, chernozem (a rich soil), anthropogenized black sand (a medium-rich soil), and anthropogenized brown sand (a poor soil), showed that the Jerusalem artichoke was superior to conventional field crops (corn, sugarbeet, potato, and sorghum) regarding the yield of carbohydrates per unit area, especially when grown on the poor soil. The analyses of the technological properties of Jerusalem artichokes grown for two years in the experimental plots showed that the plant species is a quality raw material for the production of alcohol. From the aspect of alcohol production, the quality of the tested varieties of Jerusalem artichoke depended neither on soil quality nor on the delay in harvesting the crop after it reached technological maturity. The results of the study indicate that the alcohol production from Jerusalem artichokes would be more economic, i.e., more profitable, than the production from conventional raw materials. The study of the carbohydrate composition of Jerusalem artichoke tubers made it clear that besides alcohol production, Jerusalem artichokes are a good raw material for the production of high-fructose syrup and crystalline fructose. Since the interest in these products kept increasing in recent years, because of their exceptional characters, it is necessary to establish research programs to cover these field too. In the course of the study the authors came across some interesting literature data on the use of Jerusalem artichokes as a raw material for the production of high-fructose syrup and crystalline fructose. Some of the publication, i.e., those that might be useful in further research work, are appended to this study.

  18. Evaluation of Written Examination Questions of Turkish Language in Accordance with Bloom's Taxonomy = Vrednovanje Pitanja Pismenoga Ispita Znanja iz Turskoga Jezika Prema Bloomovoj Taksonomui

    ERIC Educational Resources Information Center

    Göçer, Ali

    2011-01-01

    Problem Statement: The intention of this study is to determine whether written examination questions used in primary education fulfill their purpose in measuring students' verbal skills acquisition or not, whether the distribution of the written examination questions on the cognitive domain sublevels is balanced or not, and whether the examination…

  19. 76 FR 73760 - In the Matter of the Designation of Imad Fa'iz Mughniyah also Known as Imad Fayiz Mughniyah as a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ... Designated Global Terrorist Pursuant to Section 1(b) of Executive Order 13224, as Amended In accordance with... a Specially Designated Global Terrorist pursuant to section 1(b) of the Order. This notice shall...

  20. Silver bullet or trojan horse? The effects of inclusionary zoning on local housing markets in the United States.

    PubMed

    Schuetz, Jenny; Meltzer, Rachel; Been, Vicki

    2011-01-01

    Many local governments are adopting inclusionary zoning (IZ) as a means of producing affordable housing without direct public subsidies. In this paper, panel data on IZ in the San Francisco metropolitan area and suburban Boston are used to analyse how much affordable housing the programmes produce and how IZ affects the prices and production of market-rate housing. The amount of affordable housing produced under IZ has been modest and depends primarily on how long IZ has been in place. Results from suburban Boston suggest that IZ has contributed to increased housing prices and lower rates of production during periods of regional house price appreciation. In the San Francisco area, IZ also appears to increase housing prices in times of regional price appreciation, but to decrease prices during cooler regional markets. There is no evidence of a statistically significant effect of IZ on new housing development in the Bay Area. PMID:21275196

  1. Structure modeling and growing AgClхBr1-х, Ag1-xTlxBr1-xIx, and Ag1-xTlxClyIzBr1-y-z crystals for infrared fiber optics

    NASA Astrophysics Data System (ADS)

    Korsakov, Alexandr; Zhukova, Liya; Korsakova, Elena; Zharikov, Evgenii

    2014-01-01

    In this paper we describe the aggregate technology of producing variable composition crystals, based on the solid solutions of silver and Tl+-doped halides for creating infrared photonic crystal fibers in the spectral range of 2-40 μm by extruding, we also produce all the necessary equipment. We specified the minimum melting point position for the AgCl-AgBr phase diagram. We also investigated the fundamental physical properties of new crystals and fibers: transmission losses, transmission range, refraction index, hardness, and density.

  2. Magnetic source imaging in posterior cortex epilepsies.

    PubMed

    Badier, Jean-Michel; Bartolomei, Fabrice; Chauvel, Patrick; Bénar, Christian-George; Gavaret, Martine

    2015-01-01

    Posterior cortex epilepsies (PCE) are characterized by less satisfying postoperative results than temporal lobe epilepsies and are thus challenging for non-invasive presurgical investigations. The objective of this study was to evaluate the performance of magnetic source imaging (MSI) in PCE, validating the results by the SEEG (stereoelectroencephalography) definition of irritative and epileptogenic zones (IZ and EZ). Fourteen PCE surgery candidates were investigated using MSI and SEEG. LCMV (Linearly Constrained Minimum Variance) and MUSIC algorithms were used. IZ was quantified using a semi-automatic detection of interictal spikes. EZ was quantified using the epileptogenicity index (EI) method that accounts for both the propensity of a brain area to generate rapid discharges and the time for this area to get involved in the seizure. EI values range from 0 (no epileptogenicity) to 1 (maximal epileptogenicity). Levels of concordance between MSI and IZ, MSI and EZ were determined as follows: A = localized on MSI and SEEG for the site of value 1 (IZ and EZ quantification), B = localized on MSI and SEEG for a part of the IZ or a structure involved in the EZ (without the maximal value 1), C = localized on MSI and not SEEG, D = localized on SEEG and not MSI, E = localized on MSI and SEEG, discordant for site. Five PCE cases were characterized by focal IZ, nine by distributed IZ between several distant brain areas. MSI allowed to determinate IZ in 4/5 focal IZ cases. In case of distributed IZ, levels of concordance were A (2 cases), B (4 cases) and D (3 cases). In most distributed cases, MSI allowed to localize only a part of the IZ. Medial temporal involvement in the IZ was frequent (9/12 cases) and not evidenced by MSI. The brain area that demonstrated the maximal value of EI was shown by MSI in four out of five (80 %) focal IZ cases, in two out of nine (22 %) distributed cases. MSI results depend on IZ characteristics. A distributed IZ organization

  3. Is Inclusionary Zoning Inclusionary? A Guide for Practitioners. Technical Report

    ERIC Educational Resources Information Center

    Schwartz, Heather L.; Ecola, Liisa; Leuschner, Kristin J.; Kofner, Aaron

    2012-01-01

    Inclusionary zoning (IZ) has become an increasingly popular tool for providing affordable housing in an economically integrative manner. IZ policies typically require developers to set aside a proportion of units in market-rate residential developments to be made affordable for lower-income households in exchange for development rights or zoning…

  4. Immunosilencing a Highly Immunogenic Protein Trimerization Domain*

    PubMed Central

    Sliepen, Kwinten; van Montfort, Thijs; Melchers, Mark; Isik, Gözde; Sanders, Rogier W.

    2015-01-01

    Many therapeutic proteins and protein subunit vaccines contain heterologous trimerization domains, such as the widely used GCN4-based isoleucine zipper (IZ) and the T4 bacteriophage fibritin foldon (Fd) trimerization domains. We found that these domains induced potent anti-IZ or anti-Fd antibody responses in animals when fused to an HIV-1 envelope glycoprotein (Env) immunogen. To dampen IZ-induced responses, we constructed an IZ domain containing four N-linked glycans (IZN4) to shield the underlying protein surface. When fused to two different vaccine antigens, HIV-1 Env and influenza hemagglutinin (HA), IZN4 strongly reduced the antibody responses against the IZ, but did not affect the antibody titers against Env or HA. Silencing of immunogenic multimerization domains with glycans might be relevant for therapeutic proteins and protein vaccines. PMID:25635058

  5. What Are Normal Puberty, Precocious Puberty, and Delayed Puberty?

    MedlinePlus

    ... a long-lasting condition known as hypogonadism (pronounced HI-poe-GO-nad-iz-uhm ) in which the ... Turner syndrome or in individuals with hypogonadotropic (pronounced HI-po-GO-nah-doe-TROH-pik ) hypogonadism, which ...

  6. Imprinted zeolite modified carbon paste electrode as a potentiometric sensor for uric acid

    NASA Astrophysics Data System (ADS)

    Khasanah, Miratul; Widati, Alfa Akustia; Fitri, Sarita Aulia

    2016-03-01

    Imprinted zeolite modified carbon paste electrode (carbon paste-IZ) has been developed and applied to determine uric acid by potentiometry. The imprinted zeolite (IZ) was synthesized by the mole ratio of uric acid/Si of 0.0306. The modified electrode was manufactured by mass ratio of carbon, IZ and solid paraffin was 40:25:35. The modified electrode had shown the measurement range of 10-5 M to 10-2 M with Nernst factor of 28.6 mV/decade, the detection limit of 5.86 × 10-6 M and the accuracy of 95.3 - 105.0%. Response time of the electrode for uric acid 10-5 M - 10-2 M was 25 - 44 s. The developed electrode showed the high selectivity toward uric acid in the urea matrix. Life time of the carbon paste-IZ electrode was 10 weeks.

  7. Evaluation of recombinant fusion protein comprising dog zona pellucida glycoprotein-3 and Izumo and individual fragments as immunogens for contraception.

    PubMed

    Shrestha, Abhinav; Wadhwa, Neerja; Gupta, Satish Kumar

    2014-01-23

    Vaccines based on gamete specific proteins have been proposed for fertility inhibition. In the present study, immunogenicity and contraceptive potential of E. coli-expressed recombinant fusion protein TT-KK-ZP3-GGG-Iz, comprising promiscuous T cell epitope of tetanus toxoid (TT) followed by dilysin linker (KK), a fragment of dog zona pellucida glycoprotein-3 (ZP3), triglycine spacer (GGG) and a fragment of dog Izumo (Iz) without any affinity tag has been evaluated in female FvB/J mice. In addition, recombinant TT-KK-ZP3 and Izumo linked to the promiscuous T cell epitope of bovine RNase (bRNase-KK-Iz) and their physical mixture were also used. SDS-PAGE and immunoblot studies revealed ∼32kDa band corresponding to TT-KK-ZP3-GGG-Iz, ∼22kDa band of TT-KK-ZP3 and ∼11kDa band of bRNase-KK-Iz. Groups of mice immunized with the above recombinant proteins led to the generation of high antibody titres against the respective proteins. Immunization with recombinant TT-KK-ZP3-GGG-Iz generated higher antibody titre as compared to mice immunized with physical mixture of TT-KK-ZP3 and bRNase-KK-Iz. Antibodies against TT-KK-ZP3-GGG-Iz and TT-KK-ZP3 recognized mouse and dog ZP and those against TT-KK-ZP3-GGG-Iz and bRNase-KK-Iz recognized mouse and dog acrosome-reacted sperm in an indirect immunofluorescence assay. Immune sera from groups of mice immunized with the above recombinant proteins led to a significant reduction in mouse in vitro fertilization. Mating studies revealed significant reduction in fertility as compared to adjuvant control group. Highest infertility was observed in group of mice immunized with TT-KK-ZP3 followed by TT-KK-ZP3-GGG-Iz. Infertility was associated with the antibody titres against ZP3, whereas no association in the inhibition of fertility and antibody titres against Izumo was observed. In conclusion, these studies revealed the contraceptive potential of ZP3, which could not be further enhanced by the inclusion of Izumo. PMID:24333343

  8. Myofascial trigger points and innervation zone locations in upper trapezius muscles

    PubMed Central

    2013-01-01

    Background Myofascial trigger points (MTrPs) are hyperirritable spots located in taut bands of muscle fibres. Electrophysiological studies indicate that abnormal electrical activity is detectable near MTrPs. This phenomenon has been described as endplate noise and it has been purported to be associated MTrP pathophysiology. Thus, it is suggested that MTrPs will be overlap the innervation zone (IZ). The purpose of this work was to describe the location of MTrPs and the IZ in the right upper trapezius. Methods We screened 71 individuals and eventually enrolled 24 subjects with neck pain and active MTrPs and 24 neck pain-free subjects with latent MTrPs. Surface electromyography (sEMG) signals were detected using an electrode matrix during isometric contraction of the upper trapezius. A physiotherapist subsequently examined the subject’s trapezius to confirm the presence of MTrPs and establish their location. IZ locations were identified by visual analysis of sEMG signals. IZ and MTrPs locations were described using an anatomical coordinate system (ACS), with the skin area covered by the matrix divided into four quadrants. Results No significant difference was observed between active and latent MTrPs locations (P = 0.6). Forty-five MTrPs were in the third quadrant of the ACS, and 3 were included in second quadrant. IZs were located approximately midway between the seventh cervical vertebrae and the acromial angle in a limited area in the second and third quadrants. The mean distance between MTrP and IZ was 10.4 ± 5.8 mm. Conclusions According to the acquired results, we conclude that IZ and MTrPs are located in well-defined areas in upper trapezius muscle. Moreover, MTrPs in upper trapezius are proximally located to the IZ but not overlapped. PMID:23758854

  9. Electromyographic Responses from the Vastus Medialis during Isometric Muscle Actions.

    PubMed

    Smith, C M; Housh, T J; Herda, T; Zuniga, J M; Camic, C L; Bergstrom, H C; Smith, D B; Weir, J P; Cramer, J T; Hill, E C; Cochrane, K C; Jenkins, N D M; Schmidt, R J; Johnson, G

    2016-07-01

    This study examined the electromyographic (EMG) responses from the vastus medialis (VM) for electrodes placed over and away from the innervation zone (IZ) during a maximal voluntary isometric contraction (MVIC) and sustained, submaximal isometric muscle action. A linear electrode array was placed on the VM to identify the IZ and muscle fiber pennation angle during an MVIC and sustained isometric muscle action at 50% MVIC. EMG amplitude and frequency parameters were determined from 7 bipolar channels of the electrode array, including over the IZ, as well as 10 mm, 20 mm and 30 mm proximal and distal to the IZ. There were no differences between the channels for the patterns of responses for EMG amplitude or mean power frequency during the sustained, submaximal isometric muscle action; however, there were differences between channels during the MVIC. The results of the present study supported the need to standardize the placement of electrodes on the VM for the assessment of EMG amplitude and mean power frequency. Based on the current findings, it is recommended that electrode placements be distal to the IZ and aligned with the muscle fiber pennation angle during MVICs, as well as sustained, submaximal isometric muscle actions. PMID:27176892

  10. Use of biomarkers in resident organisms as a tool for environmental monitoring in a cold coastal system, Tierra del Fuego Island.

    PubMed

    Comoglio, L; Amin, O; Botté, S; Marcovecchio, J

    2011-03-01

    Antioxidant status of Nacella (P) magellanica and Mytilus edulis related with heavy metal in sediment and tissues were analysed in five stations close to Ushuaia city in winter and spring. The principal component analysis produced a two-dimensional pattern of the degree of similarity between sites. The Industrial-Urban Contamination Index (IUCI) showed that the Industrial Zone (IZ) and Oil Marine Station (OMS) represent areas with anthropic inputs. Heavy metals have differential association with biomarkers depending on the species. In limpets, digestive gland presented major activities of enzyme defence in winter and gonads have shown higher values of Catalase (CAT) during spring while lipid peroxidation (LPO) presented higher values in IZ. For mussels CAT and LPO increased in spring time. For superoxide dismutase (SOD) peaks have been detected in IZ and NW stations for winter. Differences in biomarker responses due to seasons did not influence the grouping of the sites into references and contaminated groups. PMID:21035188

  11. Innervation zones of fasciculating motor units: observations by a linear electrode array

    PubMed Central

    Jahanmiri-Nezhad, Faezeh; Barkhaus, Paul E.; Rymer, William Z.; Zhou, Ping

    2015-01-01

    This study examines the innervation zone (IZ) in the biceps brachii muscle in healthy subjects and those with amyotrophic lateral sclerosis (ALS) using a 20-channel linear electromyogram (EMG) electrode array. Raster plots of individual waveform potentials were studied to estimate the motor unit IZ. While this work mainly focused on fasciculation potentials (FPs), a limited number of motor unit potentials (MUPs) from voluntary activity of 12 healthy and seven ALS subjects were also examined. Abnormal propagation of MUPs and scattered IZs were observed in fasciculating units, compared with voluntarily activated MUPs in healthy and ALS subjects. These findings can be related to muscle fiber reinnervation following motor neuron degeneration in ALS and the different origin sites of FPs compared with voluntary MUPs. PMID:26029076

  12. Flexural strength and failure modes of layered ceramic structures

    PubMed Central

    Borba, Márcia; de Araújo, Maico D.; de Lima, Erick; Yoshimura, Humberto N.; Cesar, Paulo F.; Griggs, Jason A.; Bona, Álvaro Della

    2011-01-01

    Objective to evaluate the effect of the specimen design on the flexural strength (σf) and failure mode of ceramic structures, testing the hypothesis that the ceramic material under tension controls the mechanical performance of the structure. Methods Three ceramics used as framework materials for fixed partial dentures (YZ - Vita In-Ceram YZ; IZ - Vita In-Ceram Zirconia; AL - Vita In-Ceram AL) and two veneering porcelains (VM7 and VM9) were studied. Bar-shaped specimens were produced in three different designs (n=10): monolithic, two layers (porcelain-framework) and three layers (TRI) (porcelain-framework-porcelain). Specimens were tested for three-point flexural strength at 1 MPa/s in 37°C artificial saliva. For bi-layered design, the specimens were tested in both conditions: with porcelain (PT) or framework ceramic (FT) layer under tension. Fracture surfaces were analyzed using stereomicroscope and scanning electron microscopy (SEM). Young’s modulus (E) and Poisson’s ratio (ν) were determined using ultrasonic pulse-echo method. Results were statistically analyzed by Kruskal-Wallis and Student-Newman-Keuls tests. Results Except for VM7 and VM9, significant differences were observed for E values among the materials. YZ showed the highest ν value followed by IZ and AL. YZ presented the highest σf. There was no statistical difference in the σf value between IZ and IZ-FT and between AL and AL-FT. σf values for YZ-PT, IZ-PT, IZ-TRI, AL-PT, AL-TRI were similar to the results obtained for VM7 and VM9. Two types of fracture mode were identified: total and partial failure. Significance The mechanical performance of the specimens was determined by the material under tension during testing, confirming the study hypothesis. PMID:21982199

  13. Continuous desulfurization and bacterial community structure of an integrated bioreactor developed to treat SO2 from a gas stream.

    PubMed

    Lin, Jian; Li, Lin; Ding, Wenjie; Zhang, Jingying; Liu, Junxin

    2015-11-01

    Sulfide dioxide (SO2) is often released during the combustion processes of fossil fuels. An integrated bioreactor with two sections, namely, a suspended zone (SZ) and immobilized zone (IZ), was applied to treat SO2 for 6months. Sampling ports were set in both sections to investigate the performance and microbial characteristics of the integrated bioreactor. SO2 was effectively removed by the synergistic effect of the SZ and IZ, and more than 85% removal efficiency was achieved at steady state. The average elimination capacity of SO2 in the bioreactor was 2.80g/(m(3)·hr) for the SZ and 1.50g/(m(3)·hr) for the IZ. Most SO2 was eliminated in the SZ. The liquid level of the SZ and the water content ratio of the packing material in the IZ affected SO2 removal efficiency. The SZ served a key function not only in SO2 elimination, but also in moisture maintenance for the IZ. The desired water content in IZ could be feasibly maintained without any additional pre-humidification facilities. Clone libraries of 16S rDNA directly amplified from the DNA of each sample were constructed and sequenced to analyze the community composition and diversity in the individual zones. The desulfurization bacteria dominated both zones. Paenibacillus sp. was present in both zones, whereas Ralstonia sp. existed only in the SZ. The transfer of SO2 to the SZ involved dissolution in the nutrient solution and biodegradation by the sulfur-oxidizing bacteria. This work presents a potential biological treatment method for waste gases containing hydrophilic compounds. PMID:26574096

  14. Plane symmetric metrics associated with semi-plane symmetric electromagnetic fields in higher dimensions

    NASA Astrophysics Data System (ADS)

    Liang, Canbin; Tian, Guihua

    1994-11-01

    Electromagnetic fields yielding plane symmetric metrics in higher-dimensional spacetimes are exhausted and classified. It is shown that these EM fields must fall into one of the following two cases: (i)F it =F iz =0,i=1,...,n; (ii)Ftz=0. We give the general solution to the Einstein-Maxwell equations in higher dimensions corresponding to electromagnetic fields of case (ii) withF it =F iz , which covers all even-dimensional spacetimes as well as a subcase of odd-dimensional spacetimes.

  15. 75 FR 54697 - Unblocking of Thirteen Specially Designated Nationals Pursuant to Executive Order 13224

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... HONEY CENTER), Sanaa, Yemen . AL-KADR, Ahmad Sa'id (a.k.a. AL-KANADI, Abu Abd Al-Rahman); DOB 01 Mar..., Al- Hasabah, Sanaa, Yemen; By the Shrine Next to the Gas Station, Jamal Street, Ta'iz, Yemen; Al-'Arudh Square, Khur Maksar, Aden, Yemen; Al- Nasr Street, Doha, Qatar . AWEYS, Dahir Ubeidullahi,...

  16. The Functionator 3000: Transforming Numbers and Children

    ERIC Educational Resources Information Center

    Fisher, Elaine Cerrato; Roy, George; Reeves, Charles

    2013-01-01

    Mrs. Fisher's class was learning about arithmetic functions by pretending to operate real-world "function machines" (Reeves 2006). Functions are a unifying mathematics topic, and a great deal of emphasis is placed on understanding them in prekindergarten through grade 12 (Kilpatrick and Izsák 2008). In its Algebra Content Standard,…

  17. VizieR Online Data Catalog: Light curves for variables in 5 clusters (Skottfelt+, 2015)

    NASA Astrophysics Data System (ADS)

    Skottfelt, J.; Bramich, D. M.; Figuera Jaimes, R.; Jorgensen, U. G.; Kains, N.; Arrellano Ferro, A.; Alsubai, K. A.; Bozza, V.; Calchi Novati, S.; Ciceri, S.; D'Ago, G.; Dominik, M.; Galianni, P.; Gu, S. H.; Harpsoe, K. B. W.; Haugboelle, T.; Hinse, T. C.; Hundertmark, M.; Juncher, D.; Korhonen, H.; Liebig, C.; Mancini, L.; Popovas, A.; Rabus, M.; Rahvar, S.; Scarpetta, G.; Schmidt, R. W.; Southworth, J.; Snodgrass, C.; Starkey, D.; Street, R. A.; Surdej, J.; Wang, X.-B.; Wertz, O.

    2015-01-01

    The observations were carried out with the EMCCD instrument at the Danish 1.54m telescope at La Silla, Chile. EMCCD time-series i+z photometry for all confirmed variables in our field of view in NGC 6388, NGC 6441, NGC 6528, NGC 6638, and NGC 6652. (3 data files).

  18. Genetic analysis of Karnal bunt (Neovossia indica) resistance in wheat.

    PubMed

    Kumar, M; Luthra, O P; Chawla, V; Yadav, N R; Kumar, R; Khar, A

    2003-03-01

    Embryos excised from seeds of six generations (P1, P2, F1, BC1, BC2 and F2) of a cross WH 283 WH 533 were cultured on modified MS medium already inoculated with secondary sporidia of Neovossia indica. Significant variations for callusing response (CR) (54 55-75 55%) were observed among generations but the presence or absence of N. indicia did not affect callusing response. A clear inhibition zone (IZ) was formed around each embryo showing callusing. The diameter of IZ varied significantly among generations and was maximum in the resistant genotype, WH 283 (3 60 cm). Fresh weight and dry weight of calli, initiated from embryo cultured and inoculated with N. indica, varied significantly among generations. Coefficient of infection as well as percentage of infection reflected the overdominance of susceptibility. Generation mean analysis showed that the three parameter model was adequate for diameter of IZ only. Six-parameter model showed that additive (in presence of N. indica), additive and additive dominance (in absence of N. indica) effects were also significant. Complementary type of epistasis for fresh weight of calli and dominance, and dominance dominance effects for dry weight of calli were observed in the presence of N. indica. Magnitude of additive effects was higher for diameter of IZ in three parameter model. Therefore, selection might assist in improving this trait and thus indirectly help in attaining the resistance towards N. indica. PMID:12711812

  19. "Educación Bilingüe a Nivel De Escuela Secundaria": Dual-Language Education at the High School Level

    ERIC Educational Resources Information Center

    Vazquez, Dania

    2013-01-01

    The Summer 2013 issue of "Voices in Urban Education" presents an interview with Dania Vazquez, founding principal of the Margarita Muñiz Academy, a Boston public high school offering dual-language education in Spanish and English. The first dual-language high school in Massachusetts, this Innovation School opened in the fall of 2012 with…

  20. Automatic detection of motor unit innervation zones of the external anal sphincter by multichannel surface EMG.

    PubMed

    Ullah, Khalil; Cescon, Corrado; Afsharipour, Babak; Merletti, Roberto

    2014-12-01

    A method to detect automatically the location of innervation zones (IZs) from 16-channel surface EMG (sEMG) recordings from the external anal sphincter (EAS) muscle is presented in order to guide episiotomy during child delivery. The new algorithm (2DCorr) is applied to individual motor unit action potential (MUAP) templates and is based on bidimensional cross correlation between the interpolated image of each MUAP template and two images obtained by flipping upside-down (around a horizontal axis) and left-right (around a vertical axis) the original one. The method was tested on 640 simulated MUAP templates of the sphincter muscle and compared with previously developed algorithms (Radon Transform, RT; Template Match, TM). Experimental signals were detected from the EAS of 150 subjects using an intra-anal probe with 16 equally spaced circumferential electrodes. The results of the three algorithms were compared with the actual IZ location (simulated signal) and with IZ location provided by visual analysis (VA) (experimental signals). For simulated signals, the inter quartile error range (IQR) between the estimated and the actual locations of the IZ was 0.20, 0.23, 0.42, and 2.32 interelectrode distances (IED) for the VA, 2DCorr, RT and TM methods respectively. PMID:24948528

  1. Surface Electrical Potentials of Root Cell Plasma Membranes: Implications for Ion Interactions, Rhizotoxicity, and Uptake

    PubMed Central

    Wang, Yi-Min; Kinraide, Thomas B.; Wang, Peng; Hao, Xiu-Zhen; Zhou, Dong-Mei

    2014-01-01

    Many crop plants are exposed to heavy metals and other metals that may intoxicate the crop plants themselves or consumers of the plants. The rhizotoxicity of heavy metals is influenced strongly by the root cell plasma membrane (PM) surface’s electrical potential (ψ0). The usually negative ψ0 is created by negatively charged constituents of the PM. Cations in the rooting medium are attracted to the PM surface and anions are repelled. Addition of ameliorating cations (e.g., Ca2+ and Mg2+) to the rooting medium reduces the effectiveness of cationic toxicants (e.g., Cu2+ and Pb2+) and increases the effectiveness of anionic toxicants (e.g., SeO42− and H2AsO4−). Root growth responses to ions are better correlated with ion activities at PM surfaces ({IZ}0) than with activities in the bulk-phase medium ({IZ}b) (IZ denotes an ion with charge Z). Therefore, electrostatic effects play a role in heavy metal toxicity that may exceed the role of site-specific competition between toxicants and ameliorants. Furthermore, ψ0 controls the transport of ions across the PM by influencing both {IZ}0 and the electrical potential difference across the PM from the outer surface to the inner surface (Em,surf). Em,surf is a component of the driving force for ion fluxes across the PM and controls ion-channel voltage gating. Incorporation of {IZ}0 and Em,surf into quantitative models for root metal toxicity and uptake improves risk assessments of toxic metals in the environment. These risk assessments will improve further with future research on the application of electrostatic theory to heavy metal phytotoxicity in natural soils and aquatic environments. PMID:25493475

  2. Sampling and composition of airborne particulate matter (PM10) from two locations of Mexico City

    PubMed Central

    Chirino, Yolanda I.; Sánchez-Pérez, Yesennia; Osornio-Vargas, Álvaro Román; Rosas, Irma; García-Cuellar, Claudia María

    2015-01-01

    The PM10 airborne particulate matter with an aerodynamic diameter ≤10 µm is considered as a risk factor of various adverse health outcomes, including lung cancer. Here we described the sampling and composition of PM10 collected from an industrial zone (IZ), and a commercial zone (CZ) of Mexico City. The PM10 was collected with a high-volume sampler in the above mentioned locations and both types of PM10 sampled were characterized by the content of polycyclic aromatic hydrocarbons (PAHs), metals, and endotoxin. The endotoxin PM10 content from IZ and CZ displayed 138.4 UE/mg and 170.4 UE/mg of PM10, respectively. PMID:26217815

  3. Sampling and composition of airborne particulate matter (PM10) from two locations of Mexico City.

    PubMed

    Chirino, Yolanda I; Sánchez-Pérez, Yesennia; Osornio-Vargas, Álvaro Román; Rosas, Irma; García-Cuellar, Claudia María

    2015-09-01

    The PM10 airborne particulate matter with an aerodynamic diameter ≤10 µm is considered as a risk factor of various adverse health outcomes, including lung cancer. Here we described the sampling and composition of PM10 collected from an industrial zone (IZ), and a commercial zone (CZ) of Mexico City. The PM10 was collected with a high-volume sampler in the above mentioned locations and both types of PM10 sampled were characterized by the content of polycyclic aromatic hydrocarbons (PAHs), metals, and endotoxin. The endotoxin PM10 content from IZ and CZ displayed 138.4 UE/mg and 170.4 UE/mg of PM10, respectively. PMID:26217815

  4. Gm-Realization of Controlled-Gain Current Follower Transconductance Amplifier

    PubMed Central

    Tangsrirat, Worapong

    2013-01-01

    This paper describes the conception of the current follower transconductance amplifier (CFTA) with electronically and linearly current tunable. The newly modified element is realized based on the use of transconductance cells (Gms) as core circuits. The advantage of this element is that the current transfer ratios (iz/ip and ix/iz) can be tuned electronically and linearly by adjusting external DC bias currents. The circuit is designed and analyzed in 0.35 μm TSMC CMOS technology. Simulation results for the circuit with ±1.25 V supply voltages show that it consumes only 0.43 mw quiescent power with 70 MHz bandwidth. As an application example, a current-mode KHN biquad filter is designed and simulated. PMID:24381513

  5. A novel facile synthesis and characterization of molybdenum nanowires

    PubMed Central

    2012-01-01

    We describe a straightforward technique to synthesize pure Mo nanowires (NWs) from Mo6SyIz (8,2 Iz NWs are annealed in Ar/H2 mixture leading to the formation of pure Mo NWs with similar structures as initial morphologies. Detailed microscopic characterizations show that large diameters (>15 nm) Mo NWs are highly porous, while small diameters (<7 nm) are made of solid nanocrystalline grains. We find NW of diameter 4 nm can carry up to 30 μA current without suffering structural degradation. Moreover, NWs can be elastically deformed over several cycles without signs of plastic deformation. PMID:23061810

  6. Effect of the microstructure on the lifetime of dental ceramics

    PubMed Central

    Borba, Márcia; de Araújo, Maico D.; Fukushima, Karen A.; Yoshimura, Humberto N.; Cesar, Paulo F.; Griggs, Jason A.; Della Bona, Álvaro

    2011-01-01

    Objectives To evaluate the effect of the microstructure on the Weibull and slow crack growth (SCG) parameters and on the lifetime of three ceramics used as framework materials for fixed partial dentures (FPDs) (YZ - Vita In-Ceram YZ; IZ - Vita In-Ceram Zirconia; AL - Vita In-Ceram AL) and of two veneering porcelains (VM7 and VM9). Methods Bar-shaped specimens were fabricated according to the manufacturer’s instructions. Specimens were tested in three-point flexure in 37°C artificial saliva. Weibull analysis (n=30) and a constant stress-rate test (n=10) were used to determine the Weibull modulus (m) and SCG coefficient (n), respectively. Microstructural and fractographic analyses were performed using SEM. ANOVA and Tukey’s test (α=0.05) were used to statistically analyze data obtained with both microstructural and fractographic analyses. Results YZ and AL presented high crystalline content and low porosity (0.1–0.2%). YZ had the highest characteristic strength (σ0) value (911 MPa) followed by AL (488 MPa) and IZ (423 MPa). Lower σ0 values were observed for the porcelains (68–75 MPa). Except for IZ and VM7, m values were similar among the ceramic materials. Higher n values were found for YZ (76) and AL (72), followed by IZ (54) and the veneering materials (36–44). Lifetime predictions showed that YZ was the material with the best mechanical performance. The size of the critical flaw was similar among the framework materials (34–48 µm) and among the porcelains (75–86 µm). Significance The microstructure influenced the mechanical and SCG behavior of the studied materials and, consequently, the lifetime predictions. PMID:21536324

  7. 31 CFR Appendix B to Chapter V - Alphabetical Listing of Vessels That Are the Property of Blocked Persons or Specially Designated...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... YIDN State Org. of Iraqi Ports DUMP BARGE I IRAQ Gibralter Service 1,330 J8IY Whale Shipping Ltd., c/o State Org. of Iraqi Ports DUMP BARGE II IRAQ Gibralter Service 1,330 J8IZ Whale Shipping Ltd., c/o State Org. of Iraqi Ports DUMP BARGE III IRAQ Gibralter Service 1,330 J8JA Whale Shipping Ltd., c/o...

  8. Towards an informative mutant phenotype for every bacterial gene

    SciTech Connect

    Deutschbauer, Adam; Price, Morgan N.; Wetmore, Kelly M.; Tarjan, Daniel R.; Xu, Zhuchen; Shao, Wenjen; Leon, Dacia; Arkin, Adam P.; Skerker, Jeffrey M.

    2014-08-11

    Mutant phenotypes provide strong clues to the functions of the underlying genes and could allow annotation of the millions of sequenced yet uncharacterized bacterial genes. However, it is not known how many genes have a phenotype under laboratory conditions, how many phenotypes are biologically interpretable for predicting gene function, and what experimental conditions are optimal to maximize the number of genes with a phenotype. To address these issues, we measured the mutant fitness of 1,586 genes of the ethanol-producing bacterium Zymomonas mobilis ZM4 across 492 diverse experiments and found statistically significant phenotypes for 89% of all assayed genes. Thus, in <i>Z. mobilis, most genes have a functional consequence under laboratory conditions. We demonstrate that 41% of <i>Z. mobilis genes have both a strong phenotype and a similar fitness pattern (cofitness) to another gene, and are therefore good candidates for functional annotation using mutant fitness. Among 502 poorly characterized <i>Z. mobilis genes, we identified a significant cofitness relationship for 174. For 57 of these genes without a specific functional annotation, we found additional evidence to support the biological significance of these gene-gene associations, and in 33 instances, we were able to predict specific physiological or biochemical roles for the poorly characterized genes. Last, we identified a set of 79 diverse mutant fitness experiments in <i>Z. mobilis that are nearly as biologically informative as the entire set of 492 experiments. Therefore, our work provides a blueprint for the functional annotation of diverse bacteria using mutant fitness.

  9. VizieR Online Data Catalog: Photometric brown-dwarf classification (Skrzypek+, 2016)

    NASA Astrophysics Data System (ADS)

    Skrzypek, N.; Warren, S. J.; Faherty, J. K.

    2016-02-01

    Table 3 (L dwarfs) and Table 4 (T dwarfs) provide coordinates and photometry of the 1281 L dwarfs and 80 T dwarfs, J<17.5, found by Skrzypek et al. 2016 using the photo-type classification method. Coordinates and photometry in izYJHKW1W2 (on the Vega system) is provided, as well as the photo-type classification, and any existing spectroscopic classification in the literature. (3 data files).

  10. Single event upset susceptibility testing of the Xilinx Virtex II FPGA

    NASA Technical Reports Server (NTRS)

    Yui, C.; Swift, G.; Carmichael, C.

    2002-01-01

    Heavy ion testing of the Xilinx Virtex IZ was conducted on the configuration, block RAM and user flip flop cells to determine their single event upset susceptibility using LETs of 1.2 to 60 MeVcm^2/mg. A software program specifically designed to count errors in the FPGA is used to reveal L1/e values and single-event-functional interrupt failures.

  11. Differential gene expression in migratory streams of cortical interneurons

    PubMed Central

    Antypa, Mary; Faux, Clare; Eichele, Gregor; Parnavelas, John G; Andrews, William D

    2011-01-01

    Cortical interneurons originate in the ganglionic eminences of the subpallium and migrate into the cortex in well-defined tangential streams. At the start of corticogenesis, two streams of migrating neurons are evident: a superficial one at the level of the preplate (PPL), and a deeper one at the level of the intermediate zone (IZ). Currently, little is known about the signalling mechanisms that regulate interneuron migration, and almost nothing is known about the molecules that may be involved in their choice of migratory stream. Here, we performed a microarray analysis, comparing the changes in gene expression between cells migrating in the PPL and those migrating in the IZ at embryonic day 13.5. This analysis identified genes, many of them novel, that were upregulated in one of the two streams. Moreover, polymerase chain reaction, in situ hybridization experiments and immunohistochemistry showed the expression of these genes in interneurons migrating within the PPL or IZ, suggesting that they play a role in their migration and choice of stream. PMID:22103416

  12. Molecules and mechanisms that regulate multipolar migration in the intermediate zone

    PubMed Central

    Cooper, Jonathan A.

    2014-01-01

    Most neurons migrate with an elongated, “bipolar” morphology, extending a long leading process that explores the environment. However, when immature projection neurons enter the intermediate zone (IZ) of the neocortex they become “multipolar”. Multipolar cells extend and retract cytoplasmic processes in different directions and move erratically—sideways, up and down. Multipolar cells extend axons while they are in the lower half of the IZ. Remarkably, the cells then resume radial migration: they reorient their centrosome and Golgi apparatus towards the pia, transform back to bipolar morphology, and commence locomotion along radial glia (RG) fibers. This reorientation implies the existence of directional signals in the IZ that are ignored during the multipolar stage but sensed after axonogenesis. In vivo genetic manipulation has implicated a variety of candidate directional signals, cell surface receptors, and signaling pathways, that may be involved in polarizing multipolar cells and stabilizing a pia-directed leading process for radial migration. Other signals are implicated in starting multipolar migration and triggering axon outgrowth. Here we review the molecules and mechanisms that regulate multipolar migration, and also discuss how multipolar migration affects the orderly arrangement of neurons in layers and columns in the developing neocortex. PMID:25452716

  13. THE GALACTIC O-STAR SPECTROSCOPIC SURVEY. I. CLASSIFICATION SYSTEM AND BRIGHT NORTHERN STARS IN THE BLUE-VIOLET AT R {approx} 2500

    SciTech Connect

    Sota, A.; Maiz Apellaniz, J.; Alfaro, E. J.; Barba, R. H.; Morrell, N. I.; Gamen, R. C.

    2011-04-01

    We present the first installment of a massive spectroscopic survey of Galactic O stars, based on new, high signal-to-noise ratio, R {approx} 2500 digital observations from both hemispheres selected from the Galactic O-Star Catalog of MaIz Apellaniz et al. and Sota et al. The spectral classification system is rediscussed and a new atlas is presented, which supersedes previous versions. Extensive sequences of exceptional objects are given, including types Ofc, ON/OC, Onfp, Of?p, Oe, and double-lined spectroscopic binaries. The remaining normal spectra bring this first sample to 184 stars, which is close to complete to B = 8 and north of {delta} = -20{sup 0} and includes all of the northern objects in MaIz Apellaniz et al. that are still classified as O stars. The systematic and random accuracies of these classifications are substantially higher than previously attainable, because of the quality, quantity, and homogeneity of the data and analysis procedures. These results will enhance subsequent investigations in Galactic astronomy and stellar astrophysics. In the future, we will publish the rest of the survey, beginning with a second paper that will include most of the southern stars in MaIz Apellaniz et al.

  14. Infrared observations of nova V5588 Sagittarii

    NASA Astrophysics Data System (ADS)

    Banerjee, D. P. K.; Ashok, N. M.

    2011-05-01

    We report near-IR 1.08 to 2.3 micron spectroscopy of the nova V5588 Sgr using the NICMOS3 imager/spectrograph and the 1.2m Mount Abu telescope of the Physical Research Laboratory. The spectra were taken on 26 April and 4 May 2011, after the large second rebrightening of the nova reported on 25.11 April (Munari et al., CBET 2707) when it reached V = 11.7, a brightness level comparable to that of the primary maximum of V = 11.2 reached on 7 April 2011.

  15. Temperature thresholds and thermal requirements for development of Nasonovia ribisnigri (Hemiptera: Aphididae).

    PubMed

    Diaz, Beatriz Maria; Muñiz, Mariano; Barrios, Laura; Fereres, Alberto

    2007-08-01

    Early detection of Nasonovia ribisnigri (Mosley) (Hemiptera: Aphididae) on lettuce is of primary importance for its effective control. Temperature thresholds for development of this pest were estimated using developmental rates [r(T)] at different constant temperatures (8, 12, 16, 20, 24, 26, and 28 degrees C). Observed developmental rates data and temperature were fitted to two linear (Campbell and Muñiz and Gil) and a nonlinear (Lactin) models. Lower temperature threshold estimated by the Campbell model was 3.6 degrees C for apterous, 4.1 degrees C for alates, and 3.1 degrees C for both aphid adult morphs together. Similar values of the lower temperature threshold were obtained with the Muñiz and Gil model, for apterous (4.0 degrees C), alates (4.2 degrees C), and both adult morphs together (3.7 degrees C) of N. ribisnigri. Thermal requirements of N. ribisnigri to complete development were estimated by Campbell and Muñiz and Gil models for apterous in 125 and 129 DD and for both adult morphs together in 143 and 139 DD, respectively. For complete development from birth to adulthood, the alate morph needed 15-18 DD more than the apterous morph. The lower temperature threshold determined by the Lactin model was 5.3 degrees C for alates, 2.3 degrees C for apterous, and 1.9 degrees C for both adult morphs together. The optimal and upper temperature thresholds were 25.2 and 33.6 degrees C, respectively, for the alate morph, 27 and 35.9 degrees C, respectively, for the apterous morph, and 26.1 and 35.3 degrees C, respectively, for the two adult morphs together. The Campbell model provided the best fit to the observed developmental rates data of N. ribisnigri. This information could be incorporated in forecasting models of this pest. PMID:17716458

  16. DES J0454-4448: discovery of the first luminous z ≥ 6 quasar from the Dark Energy Survey

    NASA Astrophysics Data System (ADS)

    Reed, S. L.; McMahon, R. G.; Banerji, M.; Becker, G. D.; Gonzalez-Solares, E.; Martini, P.; Ostrovski, F.; Rauch, M.; Abbott, T.; Abdalla, F. B.; Allam, S.; Benoit-Levy, A.; Bertin, E.; Buckley-Geer, E.; Burke, D.; Carnero Rosell, A.; da Costa, L. N.; D'Andrea, C.; DePoy, D. L.; Desai, S.; Diehl, H. T.; Doel, P.; Cunha, C. E.; Estrada, J.; Evrard, A. E.; Fausti Neto, A.; Finley, D. A.; Fosalba, P.; Frieman, J.; Gruen, D.; Honscheid, K.; James, D.; Kent, S.; Kuehn, K.; Kuropatkin, N.; Lahav, O.; Maia, M. A. G.; Makler, M.; Marshall, J.; Merritt, K.; Miquel, R.; Mohr, J.; Nord, B.; Ogando, R.; Plazas, A.; Romer, K.; Roodman, A.; Rykoff, E.; Sako, M.; Sanchez, E.; Santiago, B.; Schubnell, M.; Sevilla, I.; Smith, C.; Soares-Santos, M.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Thomas, D.; Tucker, D.; Walker, A.; Wechsler, R. H.

    2015-12-01

    We present the first results of a survey for high-redshift, z ≥ 6, quasars using izY multicolour photometric observations from the Dark Energy Survey (DES). Here we report the discovery and spectroscopic confirmation of the zAB, YAB = 20.2, 20.2 (M1450 = -26.5) quasar DES J0454-4448 with a redshift of z = 6.09±0.02 based on the onset of the Ly α forest and an H I near zone size of 4.1_{-1.2}^{+1.1} proper Mpc. The quasar was selected as an i-band drop out with i-z = 2.46 and zAB < 21.5 from an area of ˜300 deg2. It is the brightest of our 43 candidates and was identified for spectroscopic follow-up solely based on the DES i-z and z-Y colours. The quasar is detected by WISE and has W1AB = 19.68. The discovery of one spectroscopically confirmed quasar with 5.7 < z < 6.5 and zAB ≤ 20.2 is consistent with recent determinations of the luminosity function at z ˜ 6. DES when completed will have imaged ˜5000 deg2 to YAB = 23.0 (5σ point source) and we expect to discover 50-100 new quasars with z > 6 including 3-10 with z > 7 dramatically increasing the numbers of quasars currently known that are suitable for detailed studies.

  17. Characterization of manganese peroxidases from the hyperlignolytic fungus IZU-154.

    PubMed Central

    Matsubara, M; Suzuki, J; Deguchi, T; Miura, M; Kitaoka, Y

    1996-01-01

    Four isozymes of manganese peroxidase (MnP) were identified in the culture fluid of the hyperlignolytic fungus IZU-154 under nitrogen starvation conditions. One of them was purified and characterized kinetically. The specific activity and Kcat/K(m) value of the MnP from IZU-154 were 1.6 times higher than those of the MnP from a typical lignin-degrading fungus, Phanerochaete chrysosporium. Two cDNAs encoding MnP isozymes from IZU-154 were isolated. The coding sequence of the two cDNAs, IZ-MnP1 cDNA and IZ-MnP2 cDNA, were 1,152 (384 amino acids) and 1,155 (385 amino acids) bp in length, respectively. They exhibit 96.2% identity at the nucleotide level and 95.1% identity at the amino acid level. Southern blot analysis indicated that two MnP isozyme genes exist in IZU-154 genomic DNA. The primary structures of two MnPs from IZU-154 were similar to those of MnPs from P. chrysosporium. The amino acid sequences including the important residues identified in MnPs from P. chrysosporium, such as the manganese-binding residues, the calcium-binding residues, the disulfide bonds, and the N-glycosylation site, were conserved in the two deduced IZ-MnPs. However, several discrepancies were found in the context around the distal histidine residue between MnP from IZU-154 and MnP from P. chrysosporium, which likely led to the difference in the kinetic parameters for MnP function. PMID:8899997

  18. Antioxidant and antibacterial activities of the leaf essential oil and its constituents furanodienone and curzerenone from Lindera pulcherrima (Nees.) Benth. ex hook. f.

    PubMed Central

    Joshi, Subhash C.; Mathela, Chandra S.

    2012-01-01

    Background: Lindera pulcherrima (Nees.) Benth. ex Hook. f. (Family: Lauraceae), an evergreen shrub, is an important medicinal plant distributed in temperate Himalayan regions. The leaves and bark are used as spice in cold, fever, and cough. Materials and Methods: In this study, the terpenoid composition, antioxidant, and antibacterial activities of the leaf essential oil and its major constituents are being analyzed. Conclusion: The in vitro antioxidant activity showed a potent free radical scavenging activity for the essential oil as evidenced by a low IC50 value for DPPH radical followed by furanodienone (0.087 ± 0.03 and 1.164 ± 0.58 mg/ml respectively) and the inhibition of lipid peroxidation for the oil and furanodienone also followed the same order (IC50 0.74 ± 0.13 and 2.12 ± 0.49 mg/ml, respectively). The oil and the constituents were also tested against three Gram negative (Escherichia coli, Salmonella enterica enterica, and (Pasturella multocida) and one Gram positive (Staphylococcus aureus) bacteria. The essential oil was effective against S. aureus (IZ = 19.0 ± 0.34; MIC 3.90 μl/ml) while furanodienone showed potent activity against E. coli and S. enterica enterica (IZ = 18.0 ± 0.14 and 16.0 ± 0.10 respectively). On the other hand, curzerenone was found to be slightly effective against E. coli (IZ = 10.8 ± 0.52). The MIC value of the essential oil was least against S. aureus (MIC = 3.90 μl/ml) and that of furanodienone against E. coli (MIC = 3.90 μl/ml). PMID:22518079

  19. Distribution, diversity and abundance of bacterial laccase-like genes in different particle size fractions of sediments in a subtropical mangrove ecosystem.

    PubMed

    Luo, Ling; Zhou, Zhi-Chao; Gu, Ji-Dong

    2015-10-01

    This study investigated the diversity and abundance of bacterial lacasse-like genes in different particle size fractions, namely sand, silt, and clay of sediments in a subtropical mangrove ecosystem. Moreover, the effects of nutrient conditions on bacterial laccase-like communities as well as the correlation between nutrients and, both the abundance and diversity indices of laccase-like bacteria in particle size fractions were also studied. Compared to bulk sediments, Bacteroidetes, Caldithrix, Cyanobacteria and Chloroflexi were dominated in all 3 particle-size fractions of intertidal sediment (IZ), but Actinobacteria and Firmicutes were lost after the fractionation procedures used. The diversity index of IZ fractions decreased in the order of bulk > clay > silt > sand. In fractions of mangrove forest sediment (MG), Verrucomicrobia was found in silt, and both Actinobacteria and Bacteroidetes appeared in clay, but no new species were found in sand. The declining order of diversity index in MG fractions was clay > silt > sand > bulk. Furthermore, the abundance of lacasse-like bacteria varied with different particle-size fractions significantly (p < 0.05), and decreased in the order of sand > clay > silt in both IZ and MG fractions. Additionally, nutrient availability was found to significantly affect the diversity and community structure of laccase-like bacteria (p < 0.05), while the total organic carbon contents were positively related to the abundance of bacterial laccase-like genes in particle size fractions (p < 0.05). Therefore, this study further provides evidence that bacterial laccase plays a vital role in turnover of sediment organic matter and cycling of nutrients. PMID:25822201

  20. DES J0454-4448: discovery of the first luminous z ≥ 6 quasar from the Dark Energy Survey

    SciTech Connect

    Reed, S. L.; McMahon, R. G.; Banerji, M.; Becker, G. D.; Gonzalez-Solares, E.; Martini, P.; Ostrovski, F.; Rauch, M.; Abbott, T.; Abdalla, F. B.; Allam, S.; Benoit-Levy, A.; Bertin, E.; Buckley-Geer, E.; Burke, D.; Carnero Rosell, A.; da Costa, L. N.; D'Andrea, C.; DePoy, D. L.; Desai, S.; Diehl, H. T.; Doel, P.; Cunha, C. E.; Estrada, J.; Evrard, A. E.; Fausti Neto, A.; Finley, D. A.; Fosalba, P.; Frieman, J.; Gruen, D.; Honscheid, K.; James, D.; Kent, S.; Kuehn, K.; Kuropatkin, N.; Lahav, O.; Maia, M. A. G.; Makler, M.; Marshall, J.; Merritt, K.; Miquel, R.; Mohr, J.; Nord, B.; Ogando, R.; Plazas, A.; Romer, K.; Roodman, A.; Rykoff, E.; Sako, M.; Sanchez, E.; Santiago, B.; Schubnell, M.; Sevilla, I.; Smith, C.; Soares-Santos, M.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Thomas, D.; Tucker, D.; Walker, A.; Wechsler, R. H.

    2015-10-28

    We present the first results of a survey for high-redshift, z ≥ 6, quasars using izY multicolour photometric observations from the Dark Energy Survey (DES). Here we report the discovery and spectroscopic confirmation of the zAB, YAB = 20.2, 20.2 (M1450 = -26.5) quasar DES J0454-4448 with a redshift of z = 6.09±0.02 based on the onset of the Ly α forest and an H I near zone size of 4.1+1.1-1.2 proper Mpc. The quasar was selected as an i-band drop out with i-z = 2.46 and zAB < 21.5 from an area of ~300 deg2. It is the brightest of our 43 candidates and was identified for spectroscopic follow-up solely based on the DES i-z and z-Y colours. The quasar is detected by WISE and has W1AB = 19.68. The discovery of one spectroscopically confirmed quasar with 5.7 < z < 6.5 and zAB ≤ 20.2 is consistent with recent determinations of the luminosity function at z ~ 6. DES when completed will have imaged ~5000 deg2 to YAB = 23.0 (5σ point source) and we expect to discover 50–100 new quasars with z > 6 including 3–10 with z > 7 dramatically increasing the numbers of quasars currently known that are suitable for detailed studies.

  1. Transmural Distribution of Metabolic Abnormalities and Glycolytic Activity during Dobutamine Induced Demand Ischemia

    PubMed Central

    Jameel, Mohammad N; Wang, Xiaohong; Eijgelshoven, Marcel H.J.; Mansoor, Abdul; Zhang, Jianyi

    2008-01-01

    The heterogeneity across the LV wall is characterized by higher rates of oxygen consumption, systolic thickening fraction, myocardial perfusion and lower energetic state in the subendocardial layers (ENDO). During dobutamine stimulation induced demand ischemia, the transmural distribution of energy demand and metabolic markers of ischemia are not known. In this study, hemodynamics, transmural high energy phosphate (HEP) and 2-deoxyglucose-6-phosphate (2DGP) levels and myocardial blood flow (MBF) were determined under basal conditions (B), during dobutamine infusion (DOB: 20 μg/kg/min iv.), and during coronary stenosis+DOB+2-deoxy-glucose (2DG) infusion. DOB increased rate pressure products (RPP) and MBF significantly without affecting subendocardial to subepicardial blood flow ratio (ENDO/EPI) or HEP levels. During coronary stenosis+DOB+2-deoxy-glucose (2DG) infusion RPP, ischemic zone (IZ) MBF and ENDO/EPI decreased significantly. IZ PCr/ATP decreased significantly (2.30 +/- 0.14, 2.06 +/- 0.13 and 2.04 +/- 0.11 to 1.77 +/- 0.12, 1.70 +/- 0.11 and 1.72 +/- 0.12; EPI, MID and ENDO, respectively) and 2DG6P accumulated in all layers as evidenced by the 2DG6P/PCr (0.55 +/- 0.12, 0.52 +/- 0.10 and 0.37 +/- 0.08; EPI, MID and ENDO respectively; p<0.05, EPI>ENDO). In the IZ the wet weight/dry weight ratio was significantly increased as compared to the normal zone (5.9 +/- 0.5 vs. 4.4 +/- 0.4; p<0.05). Thus, in stenotic perfused bed, during dobutamine induced high cardiac workstate, despite higher blood flow the subepicardial layers showed the greater metabolic changes that characterized by a shift toward higher carbohydrate metabolism suggesting a homeostatic responses to high cardiac workstate is characterized by more glucose utilization in energy metabolism. PMID:18424629

  2. In-vitro Callus Propagation and Secondary Metabolite Quantification in Sericostoma pauciflorum.

    PubMed

    C Jain, Satish; Pancholi, Boskey; Jain, Renuka

    2012-01-01

    Sericostoma pauciflorum Stocks ex Wight (Family Boraginaceae) used against cancer, diabetes and known to be health promoter. Callus cultures have been established from the stem explants on Murashige and Skoog (MS) medium supplemented with 1.5 mg/L concentration of different growth hormone viz. kinetin (Kn), indole 3-acetic acid (IAA) and indole 3-butyric acid (IBA). At 6 weeks of age, these calli were harvested, dried and extracted successively in pet, ether, methanol and water. Extracts were dried, weighed (%) and analyzed for their bioefficacies. Antimicrobial activities were determined using agar well diffusion and antioxidant potentials by DPPH and FRAP methods. Among all the test extracts, the extract of stem callus raised on IBA found to be more effective whereas it's pet. ether extract showed appreciable activity against both the test bacteria and fungi (S. aureus- IZ 14.00 ± 0.57 mm and T. rubrum- 16.33 ± 0.32 mm), followed by methanol extract (S. aureus- IZ 13.00 ± 0.57 mm, A. niger and P. chrysogenum- IZ 16.66 mm in both). In antioxidant potentials, all aqueous extracts were more active where IBA and Kn extracts demonstrated 0.06 mg/mL IC50 value (% inhibition 93.30 and 92.70 respectively at 0.8 mg/mL concentration) with 366 ± 6.69 and 343 ± 3.34 ascorbic acid equivalent antioxidant potentials at 1 mg/mL concentration. Furthermore, the chemical profile of test extracts was carried out. The bioactive secondary metabolites, β-sitosterol and caffeic acid was isolated from culture tissue of 6 weeks-old callus, and their identification and confirmation was carried out by color reaction, TLC behavior and IR spectrum techniques. PMID:24250543

  3. In-vitro Callus Propagation and Secondary Metabolite Quantification in Sericostoma pauciflorum

    PubMed Central

    C. Jain, Satish; Pancholi, Boskey; Jain, Renuka

    2012-01-01

    Sericostoma pauciflorum Stocks ex Wight (Family Boraginaceae) used against cancer, diabetes and known to be health promoter. Callus cultures have been established from the stem explants on Murashige and Skoog (MS) medium supplemented with 1.5 mg/L concentration of different growth hormone viz. kinetin (Kn), indole 3-acetic acid (IAA) and indole 3-butyric acid (IBA). At 6 weeks of age, these calli were harvested, dried and extracted successively in pet, ether, methanol and water. Extracts were dried, weighed (%) and analyzed for their bioefficacies. Antimicrobial activities were determined using agar well diffusion and antioxidant potentials by DPPH and FRAP methods. Among all the test extracts, the extract of stem callus raised on IBA found to be more effective whereas it’s pet. ether extract showed appreciable activity against both the test bacteria and fungi (S. aureus- IZ 14.00 ± 0.57 mm and T. rubrum- 16.33 ± 0.32 mm), followed by methanol extract (S. aureus- IZ 13.00 ± 0.57 mm, A. niger and P. chrysogenum- IZ 16.66 mm in both). In antioxidant potentials, all aqueous extracts were more active where IBA and Kn extracts demonstrated 0.06 mg/mL IC50 value (% inhibition 93.30 and 92.70 respectively at 0.8 mg/mL concentration) with 366 ± 6.69 and 343 ± 3.34 ascorbic acid equivalent antioxidant potentials at 1 mg/mL concentration. Furthermore, the chemical profile of test extracts was carried out. The bioactive secondary metabolites, β-sitosterol and caffeic acid was isolated from culture tissue of 6 weeks-old callus, and their identification and confirmation was carried out by color reaction, TLC behavior and IR spectrum techniques. PMID:24250543

  4. Photometric brown-dwarf classification. II. A homogeneous sample of 1361 L and T dwarfs brighter than J = 17.5 with accurate spectral types

    NASA Astrophysics Data System (ADS)

    Skrzypek, N.; Warren, S. J.; Faherty, J. K.

    2016-04-01

    We present a homogeneous sample of 1361 L and T dwarfs brighter than J = 17.5 (of which 998 are new), from an effective area of 3070 deg2, classified by the photo-type method to an accuracy of one spectral sub-type using izYJHKW1W2 photometry from SDSS+UKIDSS+WISE. Other than a small bias in the early L types, the sample is shown to be effectively complete to the magnitude limit, for all spectral types L0 to T8. The nature of the bias is an incompleteness estimated at 3% because peculiar blue L dwarfs of type L4 and earlier are classified late M. There is a corresponding overcompleteness because peculiar red (likely young) late M dwarfs are classified early L. Contamination of the sample is confirmed to be small: so far spectroscopy has been obtained for 19 sources in the catalogue and all are confirmed to be ultracool dwarfs. We provide coordinates and izYJHKW1W2 photometry of all sources. We identify an apparent discontinuity, Δm ~ 0.4 mag, in the Y - K colour between spectral types L7 and L8. We present near-infrared spectra of nine sources identified by photo-type as peculiar, including a new low-gravity source ULAS J005505.68+013436.0, with spectroscopic classification L2γ. We provide revised izYJHKW1W2 template colours for late M dwarfs, types M7 to M9. The catalogue is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/589/A49

  5. ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex.

    PubMed

    Li, Qingyu; Zhang, Zhengyu; Li, Zengmin; Zhou, Mei; Liu, Bin; Pan, Le; Ma, Zhixing; Zheng, Yufang

    2013-01-01

    The radial migration of neuronal progenitor cells is critical for the development of cerebral cortex layers. They go through a critical step transforming from multipolar to bipolar before outward migration. A Disintegrin and Metalloprotease 17 (ADAM17) is a transmembrane protease which can process many substrates involved in cell-cell interaction, including Notch, ligands of EGFR, and some cell adhesion molecules. In this study, we used in utero electroporation to knock down or overexpress ADAM17 at embryonic day 14.5 (E14.5) in neuronal progenitor cells to examine the role of ADAM17 in cortical embryonic neurogenesis. Our results showed that the radial migration of ADAM17-knocked down cells were normal till E16.5 and reached the intermediate zone (IZ). Then most transfected cells stopped migration and stayed at the IZ to inner cortical plate (CP) layer at E18.5, and there was higher percentage of multipolar cells at IZ layer in the ADAM17-knocked down group compared to the cells in control group. Marker staining revealed that those ADAM17-knocked down cells differentiated normally from neural stem cells (NSCs) to neuronal intermediate progenitor cells (nIPCs) but did not differentiate into mature neurons. The migration and multipolar exit defects caused by ADAM17 knockdown could be partially rescued by over-expressing an shRNA resistant ADAM17, while overexpressing ADAM17 alone did not affect the radial migration. Taken together, our results showed for the first time that, ADAM17 is critical in regulating the multipolar-stage exit and radial migration of the nIPCs during telencephalon cortex development in mice. PMID:23755270

  6. Retrieval of vertical profiles of liquid water and ice content in mixed clouds from Doppler Radar and microwave radiometer measurements

    SciTech Connect

    Sauvageot, H.

    1996-01-01

    A new method to retrieve vertical profiles of liquid water content M{sub w}(z), ice water content M{sub i}(z), and ice particle size distribution N{sub i}(D, z) (where D is the ice particle size and z the vertical coordinate) in mixed nonprecipitating clouds using the observations of a zenith-viewing Doppler radar and of a microwave radiometer is proposed. In this method, the profile of the vertical air velocity deduced from Doppler radar measurements is used to describe the rate of production by the updrafts of water vapor in excess of saturation with respect to ice. Using a Z{sub i}-M{sub i} power-law relation with an unknown linear parameter (let {alpha}{sub i} be this parameter) and initially assuming that Z{sub w} is negligible with respect to Z{sub i} (where Z{sub w} and Z{sub i} are the radar reflectivity factors of liquid water and ice particles, respectively), the measured radar reflectivity factor profile Z{sub m}({approx}Z{sub i}) is inverted to estimate N{sub i}(D, z). From N{sub i}(D, z), the profile of the rate of water vapor that can be consumed by pure deposition on ice particles is calculated. The difference between the rate of production of the excess water vapor and the rate of deposited water vapor is an expression of the rate of liquid water generation at each level. By writing that the integral of the liquid water along the profile has to be equal to the total liquid water deduced from the microwave radiometer measurement, an estimation of the {alpha}{sub i} parameter is obtained. From {alpha}{sub i}, an estimation of the profiles M{sub w}(z), M{sub i}(z), Z{sub w}(z), Z{sub i}(z) (=Z{sub m} - Z{sub w}), and N{sub i}(D, z) is calculated. If Z{sub w} is effectively negligible with respect to Z{sub i}, the computation of the retrieved profiles is ended. If not, Z{sub i}(z) is corrected and a new estimation of the profiles is computed. The results of the numerical simulation of the algorithm are presented. 21 refs., 6 figs., 1 tab.

  7. Dose equations for shift-variant CT acquisition modes using variable pitch, tube current, and aperture, and the meaning of their associated CTDI{sub vol}

    SciTech Connect

    Dixon, Robert L.; Boone, John M.; Kraft, Robert A.

    2014-11-01

    Purpose: With the increasing clinical use of shift-variant CT protocols involving tube current modulation (TCM), variable pitch or pitch modulation (PM), and variable aperture a(t), the interpretation of the scanner-reported CTDI{sub vol} is called into question. This was addressed for TCM in their previous paper published by Dixon and Boone [Med. Phys. 40, 111920 (14pp.) (2013)] and is extended to PM and concurrent TCM/PM as well as variable aperture in this work. Methods: Rigorous convolution equations are derived to describe the accumulated dose distributions for TCM, PM, and concurrent TCM/PM. A comparison with scanner-reported CTDI{sub vol} formulae clearly identifies the source of their differences with the traditional CTDI{sub vol}. Dose distribution simulations using the convolution are provided for a variety of TCM and PM scenarios including a helical shuttle used for perfusion studies (as well as constant mA)—all having the same scanner-reported CTDI{sub vol}. These new convolution simulations for TCM are validated by comparison with their previous discrete summations. Results: These equations show that PM is equivalent to TCM if the pitch variation p(z) is proportional to 1/i(z), where i(z) is the local tube current. The simulations show that the local dose at z depends only weakly on the local tube current i(z) or local pitch p(z) due to scatter from all other locations along z, and that the “local CTDI{sub vol}(z)” or “CTDI{sub vol} per slice” do not represent a local dose but rather only a relative i(z) or p(z). The CTDI-paradigm does not apply to shift-variant techniques and the scanner-reported CTDI{sub vol} for the same lacks physical significance and relevance. Conclusions: While the traditional CTDI{sub vol} at constant tube current and pitch conveys useful information (the peak dose at the center of the scan length), CTDI{sub vol} for shift-variant techniques (TCM or PM) conveys no useful information about the associated dose

  8. THz semiconductor-based front-end receiver technology for space applications

    NASA Technical Reports Server (NTRS)

    Mehdi, Imran; Siegel, Peter

    2004-01-01

    Advances in the design and fabrication of very low capacitance planar Schottky diodes and millimeter-wave power amplifiers, more accurate device and circuit models for commercial 3-D electromagnetic simulators, and the availability of both MEMS and high precision metal machining, have enabled RF engineers to extend traditional waveguide-based sensor and source technologies well into the TI-Iz frequency regime. This short paper will highlight recent progress in realizing THz space-qualified receiver front-ends based on room temperature semiconductor devices.

  9. Polarized line formation by resonance scattering. II. Conservative case.

    NASA Astrophysics Data System (ADS)

    Ivanov, V. V.; Grachev, S. I.; Loskutov, V. M.

    1997-05-01

    We consider multiple resonance scattering with complete frequency redistribution (CFR) in a semi-infinite conservative atmosphere (photon destruction probability ɛ_I_=0) with the sources at infinite depth. The polarization arising in resonance scattering is completely accounted for. The problem we consider is the resonance-scattering counterpart of the Chandrasekhar-Sobolev problem of Rayleigh scattering in the conservative atmosphere. The numerical data on the matrix source function S(τ) in the atmosphere with conservative dipole resonance scattering (the depolarization parameter W=1) are presented; we assume Doppler profile. The source matrix is found by a non-iterative numerical solution of the matrix Wiener-Hopf integral equation with the matrix {LAMBDA}-operator. Depth dependence of the elements of the source matrix S(τ) is discussed. Some unexpected peculiarities are revealed in the behavior of its polarization terms. The matrix I(z) which is the generalization of the Chandrasekhar H-function to the case of polarized resonance scattering is found by the iterative solution of the Chandrasekhar-type nonlinear matrix integral equation. We present high-accuracy (5 s.f.) numerical data on I(z) for dipole conservative scattering with the Doppler profile. The center-to-limb variation of the degree of polarization in the core of a Doppler broadened resonance line is found. In conservative case, the limiting limb polarization δ_0_ in the core of such a line is 9.4430% (for W=1). The dependence of δ_0_ on the depolarization parameter W is found. Simple interpolation formula, δ_0_=(9.443-38.05sqrt(ɛ)_I_)%, is suggested for the limb polarization of the radiation emerging from an isothermal nearly conservative atmosphere (ɛ_I_<<1, W=1). The data on I(z) are used to find the polarization line profiles and to trace their center-to-limb variation. The asymptotic expansions of S(τ) for τ-{infinity} (deep layers) and of I(z) for z-{infinity} (line wings) are found

  10. Identification of a novel 6'-N-aminoglycoside acetyltransferase, AAC(6')-Iak, from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia.

    PubMed

    Tada, Tatsuya; Miyoshi-Akiyama, Tohru; Dahal, Rajan K; Mishra, Shyam K; Shimada, Kayo; Ohara, Hiroshi; Kirikae, Teruo; Pokhrel, Bharat M

    2014-10-01

    Stenotrophomonas maltophilia IOMTU250 has a novel 6'-N-aminoglycoside acetyltransferase-encoding gene, aac(6')-Iak. The encoded protein, AAC(6')-Iak, consists of 153 amino acids and has 86.3% identity to AAC(6')-Iz. Escherichia coli transformed with a plasmid containing aac(6')-Iak exhibited decreased susceptibility to arbekacin, dibekacin, neomycin, netilmicin, sisomicin, and tobramycin. Thin-layer chromatography showed that AAC(6')-Iak acetylated amikacin, arbekacin, dibekacin, isepamicin, kanamycin, neomycin, netilmicin, sisomicin, and tobramycin but not apramycin, gentamicin, or lividomycin. PMID:25092711

  11. 76 FR 19826 - U.S. Department of State Advisory Committee on Private International Law (ACPIL): Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE U.S... Online Dispute Resolution (ODR) Study Group The Office of the Assistant Legal Adviser for Private...-ny.un.org/doc/UNDOC/GEN/V11/801/48/PDF/V1180148.pdf?OpenElement . For the draft text of...

  12. An Active Sensor Algorithm for Corn Nitrogen Recommendations Based on a Chlorophyll Meter Algorithm

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In previous work we found active canopy sensor reflectance assessments of corn (Zea mays L.) N status acquired at two growth stages (V11 and V15) have the greatest potential for directing in-season N applications, but emphasized an algorithm was needed to translate sensor readings into appropriate N...

  13. Integrating soil and weather information into canopy sensor algorithms for improved corn nitrogen rate recommendation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Corn production can be often limited by the loss of nitrogen (N) due to leaching, volatilization and denitrification. The use of canopy sensors for making in-season N fertilizer applications has been proven effective in matching plant N requirements with periods of rapid N uptake (V7-V11), reducing ...

  14. The effect of hot salt on the mechanical properties of several superalloys

    NASA Technical Reports Server (NTRS)

    Nelson, E. E.

    1972-01-01

    The effect of sodium chloride on unstressed, transverse, tensile, metal specimens at elevated temperatures was determined. Results indicate that the mechanical properties of Inconel 718, Rene 41, titanium base alloy 13V-11Cr-3Al, Hastelloy X, HS25 (L605), HS188, and TDNiCr suffer degradation in tensile strength and ductility due to hot salt exposure.

  15. Invitational Engineering--Good Counsel Then and Now

    ERIC Educational Resources Information Center

    Shushok, Frank, Jr.; Farquhar-Caddell, Dakota A.; Krimowski, Frank M.

    2014-01-01

    In this article, Shushok, Farquhar-Caddell, and Krimowski, compare the vestiges of old residential environments as introduced in a 1981 article entitled "Invitational Engineering in the Residence Halls" by Jack Murphy and William Purkey ("The Journal of College and University Student Housing," v11 n1 p13-16 Sum 1981) (See in…

  16. Antimicrobial Activity of a Neem Cake Extract in a Broth Model Meat System

    PubMed Central

    Del Serrone, Paola; Nicoletti, Marcello

    2013-01-01

    This work reports on the antimicrobial activity of an ethyl acetate extract of neem (Azadirachta indica) cake (NCE) against bacteria affecting the quality of retail fresh meat in a broth model meat system. NCE (100 µg) was also tested by the agar disc diffusion method. It inhibited the growth of all tested microorganisms. The NCE growth inhibition zone (IZ) ranged 11.33–22.67 mm while the ciprofloxacin (10 µg) IZ ranged from 23.41–32.67 mm. There was no significant difference (p ≤ 0.05) between the antimicrobial activity of NCE and ciprofloxacin vs. C. jejuni and Leuconostoc spp. The NCE antibacterial activity was moreover determined at lower concentrations (1:10–1:100,000) in micro-assays. The percent growth reduction ranged from 61 ± 2.08–92 ± 3.21. The higher bacterial growth reduction was obtained at 10 µg concentration of NCE. Species-specific PCR and multiplex PCR with the DNA dye propidium monoazide were used to directly detect viable bacterial cells from experimentally contaminated meat samples. The numbers of bacterial cells never significantly (p ≤ 0.05) exceeded the inocula concentration used to experimentally contaminate the NCE treated meat. This report represents a screening methodology to evaluate the antimicrobial capability of a herbal extract to preserve meat. PMID:23917814

  17. Re-evaluation of EMG-torque relation in chronic stroke using linear electrode array EMG recordings.

    PubMed

    Bhadane, Minal; Liu, Jie; Rymer, W Zev; Zhou, Ping; Li, Sheng

    2016-01-01

    The objective was to re-evaluate the controversial reports of EMG-torque relation between impaired and non-impaired sides using linear electrode array EMG recordings. Ten subjects with chronic stroke performed a series of submaximal isometric elbow flexion tasks. A 20-channel linear array was used to record surface EMG of the biceps brachii muscles from both impaired and non-impaired sides. M-wave recordings for bilateral biceps brachii muscles were also made. Distribution of the slope of the EMG-torque relations for the individual channels showed a quasi-symmetrical "M" shaped pattern. The lowest value corresponded to the innervation zone (IZ) location. The highest value from the slope curve for each side was selected for comparison to minimize the effect of electrode placement and IZ asymmetry. The slope was greater on the impaired side in 4 of 10 subjects. There were a weak correlation between slope ratio and strength ratio and a moderate to high correlation between slope ratio and M-wave ratio between two sides. These findings suggest that the EMG-torque relations are likely mediated and influenced by multiple factors. Our findings emphasize the importance of electrode placement and suggest the primary role of peripheral adaptive changes in the EMG-torque relations in chronic stroke. PMID:27349938

  18. Properties and partial genetic characterization of Nepean phage and other lytic phages of Brucella species.

    PubMed

    Rigby, C E; Cerqueira-Campos, M L; Kelly, H A; Surujballi, O P

    1989-07-01

    Nepean (Np), a new brucellaphage, was associated with atypical Brucella abortus strains from Ontario cattle. Carriage of Np was associated with loss of smooth lipopolysaccharide, changes in some protein bands in acrylamide gel electrophoresis profiles, increased susceptibility to colistin, and increased resistance to ultraviolet killing. Nepean (Np) was compared with brucellaphages Tb, Fi, Wb, Iz and R/C. All were morphologically identical, with icosahedral capsids (50-65 nm diameter) and short tails (15-25 nm long), but Np had a more restricted host range, replicating only in smooth strains of B. abortus. All six brucellaphages were generally similar in resistance to chemical and physical agents. Brucellaphage DNA was double stranded and unmethylated; its molecular size was 38 kilobase pairs. The DNAs of Tb, Fi, Wb, Iz and R/C could not be differentiated by restriction endonuclease digest profiles produced by BgII, EcoRI, HindIII or PvuII. Nepean (Np) DNA was very similar to that of the other brucellaphages, but with every enzyme used its profile differed in the number and/or position of at least one fragment. However, there was complete cross-hybridization of Tb and Np DNAs. Hybridization techniques failed to detect Brucella DNA in Dp or Tb phages, or phage DNA in Brucella cells. Extrachromosomal plasmid DNA was not detected. PMID:2504475

  19. C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development

    PubMed Central

    Shah, Bhavin; Lutter, Daniela; Bochenek, Magdalena L.; Kato, Katsuhiro; Tsytsyura, Yaroslav; Glyvuk, Natalia; Sakakibara, Akira; Klingauf, Jürgen; Adams, Ralf H.; Püschel, Andreas W.

    2016-01-01

    The establishment of a polarized morphology is essential for the development and function of neurons. During the development of the mammalian neocortex, neurons arise in the ventricular zone (VZ) from radial glia cells (RGCs) and leave the VZ to generate the cortical plate (CP). During their migration, newborn neurons first assume a multipolar morphology in the subventricular zone (SVZ) and lower intermediate zone (IZ). Subsequently, they undergo a multi-to-bipolar (MTB) transition to become bipolar in the upper IZ by developing a leading process and a trailing axon. The small GTPases Rap1A and Rap1B act as master regulators of neural cell polarity in the developing mouse neocortex. They are required for maintaining the polarity of RGCs and directing the MTB transition of multipolar neurons. Here we show that the Rap1 guanine nucleotide exchange factor (GEF) C3G (encoded by the Rapgef1 gene) is a crucial regulator of the MTB transition in vivo by conditionally inactivating the Rapgef1 gene in the developing mouse cortex at different time points during neuronal development. Inactivation of C3G results in defects in neuronal migration, axon formation and cortical lamination. Live cell imaging shows that C3G is required in cortical neurons for both the specification of an axon and the initiation of radial migration by forming a leading process. PMID:27111087

  20. An Algorithm for 353 Odor Detection Thresholds in Humans

    PubMed Central

    Sánchez-Moreno, Ricardo; Cometto-Muñiz, J. Enrique; Cain, William S.

    2012-01-01

    One hundred and ninety three odor detection thresholds, ODTs, obtained by Nagata using the Japanese triangular bag method can be correlated as log (1/ODT) by a linear equation with R2 = 0.748 and a standard deviation, SD, of 0.830 log units; the latter may be compared with our estimate of 0.66 log units for the self-consistency of Nagata's data. Aldehydes, acids, unsaturated esters, and mercaptans were included in the equation through indicator variables that took into account the higher potency of these compounds. The ODTs obtained by Cometto-Muñiz and Cain, by Cometto-Muñiz and Abraham, and by Hellman and Small could be put on the same scale as those of Nagata to yield a linear equation for 353 ODTs with R2 = 0.759 and SD = 0.819 log units. The compound descriptors are available for several thousand compounds, and can be calculated from structure, so that further ODT values on the Nagata scale can be predicted for a host of volatile or semivolatile compounds. PMID:21976369

  1. Re-evaluation of EMG-torque relation in chronic stroke using linear electrode array EMG recordings

    PubMed Central

    Bhadane, Minal; Liu, Jie; Rymer, W. Zev; Zhou, Ping; Li, Sheng

    2016-01-01

    The objective was to re-evaluate the controversial reports of EMG-torque relation between impaired and non-impaired sides using linear electrode array EMG recordings. Ten subjects with chronic stroke performed a series of submaximal isometric elbow flexion tasks. A 20-channel linear array was used to record surface EMG of the biceps brachii muscles from both impaired and non-impaired sides. M-wave recordings for bilateral biceps brachii muscles were also made. Distribution of the slope of the EMG-torque relations for the individual channels showed a quasi-symmetrical “M” shaped pattern. The lowest value corresponded to the innervation zone (IZ) location. The highest value from the slope curve for each side was selected for comparison to minimize the effect of electrode placement and IZ asymmetry. The slope was greater on the impaired side in 4 of 10 subjects. There were a weak correlation between slope ratio and strength ratio and a moderate to high correlation between slope ratio and M-wave ratio between two sides. These findings suggest that the EMG-torque relations are likely mediated and influenced by multiple factors. Our findings emphasize the importance of electrode placement and suggest the primary role of peripheral adaptive changes in the EMG-torque relations in chronic stroke. PMID:27349938

  2. Trace metal content in sediments and autochthonous intertidal organisms from two adjacent bays near Ushuaia, Beagle Channel (Argentina).

    PubMed

    Duarte, Claudia Alejandra; Giarratano, Erica; Gil, Mónica N

    2012-08-01

    The aim of this work was to monitor levels of Cd, Cu, Pb, Zn and Fe in sediments, mussels (Mytilus edulis chilensis) and limpets (Nacella magellanica) from the Industrial zone (IZ); fuel dock (FD) and Ushuaia Peninsula (UP) on the Beagle Channel. In sediments, seasonal variations showed high values of Cu and Pb in spring and Zn in autumn. Comparing among sites, Cd concentration was superior in UP (2.07 μg/g); while Pb was maximum in FD (41.00 μg/g). In mussels, a higher bioaccumulation in winter was found. Mussels from UP showed the highest bioaccumulation of Cu (5.95 μg/g) and those from FD presented the highest of Zn (170.15 μg/g). A seasonal trend was not found for limpets, while differences among sites were observed for Cd being the highest at IZ (3.02 μg/g). Although pollution level found was low, anthropic activities at the studied sites could result in deterioration, further monitoring is recommended. PMID:22681905

  3. Chemical composition and in vitro evaluation of antioxidant, antimicrobial, cytotoxicity and anti-acetylcholinesterase properties of Tunisian Origanum majorana L. essential oil.

    PubMed

    Hajlaoui, Hafedh; Mighri, Hedi; Aouni, Mahjoub; Gharsallah, Néji; Kadri, Adel

    2016-06-01

    This study investigated the chemical composition and evaluated the antioxidant, antimicrobial, cytotoxic and anti-acetylcholinesterase properties of Tunisian Origanum majorana essential oil. The findings showed that the oil exhibited high activity, particularly in terms of reducing power and β-Carotene bleaching, inducing higher IC50 values than BHT. The oil showed an important antimicrobial activity against 25 bacterial and fungal strains. In fact, the IZ, MIC and MBC values recorded for the bacterial strains were in the range of 8 ± 0-18.33 ± 0.57 mm, 0.097-3.125 and 0.39-6.25 mg/mL, respectively. The IZ, MIC and MFC values of the fungal strains varied between 11±0-28 ± 0 mm, 0.058-0.468 mg/mL and 0.234-1.875 mg/mL, respectively. A low cytotoxic effect was observed against cancer (Hep-2 and HT29) and continuous cell lineage (Vero), with CC50 values ranging from 13.73 to 85.63 mg/mL. The oil was also evaluated for anti-acetylcholinesterase effects, which showed that it exhibited significant activity with IC50 values reaching 150.33 ± 2.02 μg/mL. PMID:26997648

  4. Exogenous Reelin modifies the migratory behavior of neurons depending on cortical location.

    PubMed

    Britto, Joanne M; Tait, Karen J; Lee, Ean Phing; Gamble, Robin S; Hattori, Mitsuharu; Tan, Seong-Seng

    2014-11-01

    Malformations of cortical development can arise when projection neurons generated in the germinal zones fail to migrate properly into the cortical plate. This process is critically dependent on the Reelin glycoprotein, which when absent leads to an inversion of cortical layers and blurring of borders. Reelin has other functions including supporting neuron migration and maintaining their trajectories; however, the precise role on glial fiber-dependent or -independent migration of neurons remains controversial. In this study, we wish to test the hypothesis that migrating cortical neurons at different levels of the cortical wall have differential responses to Reelin. We exposed neurons migrating across the cortical wall to exogenous Reelin and monitored their migratory behavior using time-lapse imaging. Our results show that, in the germinal zones, exogenous Reelin retarded neuron migration and altered their trajectories. This behavior is in contrast to the response of neurons located in the intermediate zone (IZ), possibly because Reelin receptors are not expressed in this zone. In the reeler cortex, Reelin receptors are expressed in the IZ and exposure to exogenous Reelin was able to rescue the migratory defect. These studies demonstrate that migrating neurons have nonequivalent responses to Reelin depending on their location within the cortical wall. PMID:23749873

  5. A one-parameter family of transforms, linearizing convolution laws for probability distributions

    NASA Astrophysics Data System (ADS)

    Nica, Alexandru

    1995-03-01

    We study a family of transforms, depending on a parameter q∈[0,1], which interpolate (in an algebraic framework) between a relative (namely: - iz(log ℱ(·)) '(-iz)) of the logarithm of the Fourier transform for probability distributions, and its free analogue constructed by D. Voiculescu ([16, 17]). The classical case corresponds to q=1, and the free one to q=0. We describe these interpolated transforms: (a) in terms of partitions of finite sets, and their crossings; (b) in terms of weighted shifts; (c) by a matrix equation related to the method of Stieltjes for expanding continued J-fractions as power series. The main result of the paper is that all these descriptions, which extend basic approaches used for q=0 and/or q=1, remain equivalent for arbitrary q∈[0, 1]. We discuss a couple of basic properties of the convolution laws (for probability distributions) which are linearized by the considered family of transforms (these convolution laws interpolate between the usual convolution — at q=1, and the free convolution introduced by Voiculescu — at q=0). In particular, we note that description (c) mentioned in the preceding paragraph gives an insight of why the central limit law for the interpolated convolution has to do with the q-continuous Hermite orthogonal polynomials.

  6. The anti-dermatophyte activity of Allium hirtifolium Boiss aqueous extract.

    PubMed

    Mahboubi, M; Kazempour, N

    2015-03-01

    In an attempt at demonstrating the efficacy of Allium hirtifolium aqueous extract in control of skin fungal infections as traditional use, we evaluated the anti-dermatophyte activities of A. hirtifolium aqueous extract from bulbs and of ketoconazole against Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, M. gypseum, Trichophyton schoenleinii and Trichophyton verrucosum var. album by food poisoning technique, disc diffusion and micro broth dilution assays. The anti-fungal activity of A. hirtifolium was excellent when it was compared with ketoconazole. The anti-fungal evaluation by food poisoning method showed that A. hirtifolium extract inhibited the growth of dermatophytes dose-dependently. The inhibition zone diameter (IZ) of A. hirtifolium extract (15 μg/disc) was in the range of 28.8 ± 0.31 to 67.7 ± 1.5mm, while ketoconazole (15 μg/disc) had the IZ lower than 13mm. The MIC and MFC values of A. hirtifolium extract were in the range of 0.2-1.7 and 0.4-0.7 μg/mL; respectively. Therefore, A. hirtifolium extract showed a strong anti-fungal activity against human and animal dermatophytes. PMID:25456419

  7. STM verification of the reduction of the Young's modulus of CdS nanoparticles at smaller sizes

    NASA Astrophysics Data System (ADS)

    Hazarika, A.; Peretz, E.; Dikovsky, V.; Santra, P. K.; Shneck, R. Z.; Sarma, D. D.; Manassen, Y.

    2014-12-01

    We demonstrate the first STM evaluation of the Young's modulus (E) of nanoparticles (NPs) of different sizes. The sample deformation induced by tip-sample interaction has been determined using current-distance (I-Z) spectroscopy. As a result of tip-sample interaction, and the induced surface deformations, the I-z curves deviates from pure exponential dependence. Normally, in order to analyze the deformation quantitatively, the tip radius must be known. We show, that this necessity is eliminated by measuring the deformation on a substrate with a known Young's modulus (Au(111)) and estimating the tip radius, and afterwards, using the same tip (with a known radius) to measure the (unknown) Young's modulus of another sample (nanoparticles of CdS). The Young's modulus values found for 3 NP's samples of average diameters of 3.7, 6 and 7.5 nm, were E ~ 73%, 78% and 88% of the bulk value, respectively. These results are in a good agreement with the theoretically predicted reduction of the Young's modulus due to the changes in hydrostatic stresses which resulted from surface tension in nanoparticles with different sizes. Our calculation using third order elastic constants gives a reduction of E which scales linearly with 1/r (r is the NP's radius). This demonstrates the applicability of scanning tunneling spectroscopy for local mechanical characterization of nanoobjects. The method does not include a direct measurement of the tip-sample force but is rather based on the study of the relative elastic response.

  8. Selection of a suitable plant for phytoremediation in mining artisanal zones.

    PubMed

    Chamba, I; Gazquez, M J; Selvaraj, T; Calva, J; Toledo, J J; Armijos, C

    2016-09-01

    A study was undertaken with the aim of identifying a suitable plant for the phytoremediation of metal-polluted soil from an artisanal mining area in Ecuador. Three zones including a natural zone (NZ), abandoned zone (AZ) and intensively mined zone (IZ) were selected. Three common native plants grown in the three zones were identified and collected, including Miconia zamorensis, Axonopus compressus and Erato polymnioides. The percentage of arbuscular mycorrhizal colonization that benefits their own survival in polluted soil was analyzed in the root samples of these candidate species. Analysis of the soils and plants collected from the different zones showed that the concentrations of Pb, Zn, Cu and Cd were comparatively lower in the NZ, higher in the AZ and IZ, and highest in the AZ for all the metals. The concentration of all these metals in plant tissues was the highest in E. polymnioides. The data analysis including the metal accumulation index, bioconcentration factor and translocation factor strongly identified E. polymnioides as a hyperaccumulator plant suitable for phytoremediation. PMID:26940037

  9. Tailoring the optimal control cost function to a desired output: application to minimizing phase errors in short broadband excitation pulses

    NASA Astrophysics Data System (ADS)

    Skinner, Thomas E.; Reiss, Timo O.; Luy, Burkhard; Khaneja, Navin; Glaser, Steffen J.

    2005-01-01

    The de facto standard cost function has been used heretofore to characterize the performance of pulses designed using optimal control theory. The freedom to choose new, creative quality factors designed for specific purposes is demonstrated. While the methodology has more general applicability, its utility is illustrated by comparison to a consistently chosen example—broadband excitation. The resulting pulses are limited to the same maximum RF amplitude used previously and tolerate the same variation in RF homogeneity deemed relevant for standard high-resolution NMR probes. Design criteria are unchanged: transformation of Iz → Ix over resonance offsets of ±20 kHz and RF variability of ±5%, with a peak RF amplitude equal to 17.5 kHz. However, the new cost effectively trades a small increase in residual z magnetization for improved phase in the transverse plane. Compared to previous broadband excitation by optimized pulses (BEBOP), significantly shorter pulses are achievable, with only marginally reduced performance. Simulations transform Iz to greater than 0.98 Ix, with phase deviations of the final magnetization less than 2°, over the targeted ranges of resonance offset and RF variability. Experimental performance is in excellent agreement with the simulations.

  10. Electrical Nuclear Quadrupolar Interaction of ZINC-67 in a Single Crystal of Zinc.

    NASA Astrophysics Data System (ADS)

    Goyette, Jacques

    The nuclear quadrupolar coupling of ('67)Zn in a single crystal of zinc has been studied using the techniques of nuclear acoustic resonance (NAR) and nuclear magnetic resonance (NMR) at low temperatures. NAR, which is an attractive way of doing resonance experiments, is analogous to NMR except in the fact that we use phonons instead of photons to induce transitions thereby avoiding the skin -depth problems met when we do NMR in single metallic crystal. While our NAR experiments were unfruitful mainly due to the large magnetoresistance effects shown by zinc at low temperatures, we were able to circumvent these problems in our NMR experiments by using a time-sharing spectrometer which did not require modulation of the magnetic field. This way, we studied the I(,z) = 1/2 to I(,z) = -1/2 magnetic resonance transition of the I = 5/2 ground state of ('67)Zn in a single crystal of zinc metal as a function of crystal orientation in a magnetic field of 72 kilogauss. The small frequency deviation versus crystal orientation has been used to evaluate the electric quadrupole interaction e('2)qQ/h as 12.19(2) Mhz, the isotropic Knight shift as 0.236(6)% and the anisotropic Knight shift as 0.013(2)% at 4.2(DEGREES)K.

  11. Excitatory cortical neurons with multipolar shape establish neuronal polarity by forming a tangentially oriented axon in the intermediate zone.

    PubMed

    Hatanaka, Yumiko; Yamauchi, Kenta

    2013-01-01

    The formation of axon-dendrite polarity is crucial for neuron to make the proper information flow within the brain. Although the processes of neuronal polarity formation have been extensively studied using neurons in dissociated culture, the corresponding developmental processes in vivo are still unclear. Here, we illuminate the initial steps of morphological polarization of excitatory cortical neurons in situ, by sparsely labeling their neuroepithelial progenitors using in utero electroporation and then examining their neuronal progeny in brain sections and in slice cultures. Morphological analysis showed that an axon-like long tangential process formed in progeny cells in the intermediate zone (IZ). Time-lapse imaging analysis using slice culture revealed that progeny cells with multipolar shape, after alternately extending and retracting their short processes for several hours, suddenly elongated a long process tangentially. These cells then transformed into a bipolar shape, extending a pia-directed leading process, and migrated radially leaving the tangential process behind, which gave rise to an "L-shaped" axon. Our findings suggest that neuronal polarity in these cells is established de novo from a nonpolarized stage in vivo and indicate that excitatory cortical neurons with multipolar shape in the IZ initiate axon outgrowth before radial migration into the cortical plate. PMID:22267309

  12. Distinct roles of neuropilin 1 signaling for radial and tangential extension of callosal axons.

    PubMed

    Hatanaka, Yumiko; Matsumoto, Tomoko; Yanagawa, Yuchio; Fujisawa, Hajime; Murakami, Fujio; Masu, Masayuki

    2009-05-20

    Cortical excitatory neurons migrate from their origin in the ventricular zone (VZ) toward the pial surface. During migration, these neurons exhibit a stellate shape in the intermediate zone (IZ), transform into bipolar cells, and then initiate radial migration, extending a trailing process, which may lead to an axon. Here we examined the role of neuropilin 1 (NRP1) in these developmental events. Both NRP1 mRNA and protein were highly expressed in the IZ, where stellate-shaped cells were located. DiI labeling experiments showed that neuronal migration occurred normally in Nrp1 mutant mice up to embryonic day (E) 14.5, the latest day to which the mutant survives, with only subtle axonal defasciculation. However, interference with Nrp1 signaling at a later stage caused pathfinding errors: when a dominant negative form of Nrp1 was electroporated into the cortical VZ cells at E12.5 or E15.5 and examined perinatally, guidance errors were found in tangential axonal extension toward the midline. In contrast, no significant effect was noted on the migration of cortical excitatory neurons. These findings indicate that NRP1 plays an important role in the guidance of callosal axons originating from cortical excitatory neurons but does not support a role in their migration. Moreover, insofar as radial axonal extension within the cortical plate was unaffected, the present findings imply that molecular mechanisms for the axonal extension of excitatory neurons within the cortical plate are distinct from those in the white matter. PMID:19296474

  13. C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development.

    PubMed

    Shah, Bhavin; Lutter, Daniela; Bochenek, Magdalena L; Kato, Katsuhiro; Tsytsyura, Yaroslav; Glyvuk, Natalia; Sakakibara, Akira; Klingauf, Jürgen; Adams, Ralf H; Püschel, Andreas W

    2016-01-01

    The establishment of a polarized morphology is essential for the development and function of neurons. During the development of the mammalian neocortex, neurons arise in the ventricular zone (VZ) from radial glia cells (RGCs) and leave the VZ to generate the cortical plate (CP). During their migration, newborn neurons first assume a multipolar morphology in the subventricular zone (SVZ) and lower intermediate zone (IZ). Subsequently, they undergo a multi-to-bipolar (MTB) transition to become bipolar in the upper IZ by developing a leading process and a trailing axon. The small GTPases Rap1A and Rap1B act as master regulators of neural cell polarity in the developing mouse neocortex. They are required for maintaining the polarity of RGCs and directing the MTB transition of multipolar neurons. Here we show that the Rap1 guanine nucleotide exchange factor (GEF) C3G (encoded by the Rapgef1 gene) is a crucial regulator of the MTB transition in vivo by conditionally inactivating the Rapgef1 gene in the developing mouse cortex at different time points during neuronal development. Inactivation of C3G results in defects in neuronal migration, axon formation and cortical lamination. Live cell imaging shows that C3G is required in cortical neurons for both the specification of an axon and the initiation of radial migration by forming a leading process. PMID:27111087

  14. Status of the SLC

    SciTech Connect

    Seeman, J.T.; Sheppard, J.C.

    1987-09-01

    The construction project for the SLAC Linear Collider (SLC) was officially completed in April 1987, following a successful test in March of passing 46-GeV positron and electron beams through the collider hall on the same accelerator pulse. Since that time, commissioning of the SLC has concentrated on making the stability, intensity and transverse dimensions of both beams suitable to generate useful luminosity near the center of mass energy of 93 GeV. 11 refs.

  15. Dose equations for tube current modulation in CT scanning and the interpretation of the associated CTDI{sub vol}

    SciTech Connect

    Dixon, Robert L.; Boone, John M.

    2013-11-15

    Purpose: The scanner-reported CTDI{sub vol} for automatic tube current modulation (TCM) has a different physical meaning from the traditional CTDI{sub vol} at constant mA, resulting in the dichotomy “CTDI{sub vol} of the first and second kinds” for which a physical interpretation is sought in hopes of establishing some commonality between the two.Methods: Rigorous equations are derived to describe the accumulated dose distributions for TCM. A comparison with formulae for scanner-reported CTDI{sub vol} clearly identifies the source of their differences. Graphical dose simulations are also provided for a variety of TCM tube current distributions (including constant mA), all having the same scanner-reported CTDI{sub vol}.Results: These convolution equations and simulations show that the local dose at z depends only weakly on the local tube current i(z) due to the strong influence of scatter from all other locations along z, and that the “local CTDI{sub vol}(z)” does not represent a local dose but rather only a relative i(z) ≡ mA(z). TCM is a shift-variant technique to which the CTDI-paradigm does not apply and its application to TCM leads to a CTDI{sub vol} of the second kind which lacks relevance.Conclusions: While the traditional CTDI{sub vol} at constant mA conveys useful information (the peak dose at the center of the scan length), CTDI{sub vol} of the second kind conveys no useful information about the associated TCM dose distribution it purportedly represents and its physical interpretation remains elusive. On the other hand, the total energy absorbed E (“integral dose”) as well as its surrogate DLP remain robust between variable i(z) TCM and constant current i{sub 0} techniques, both depending only on the total mAs =t{sub 0}=i{sub 0} t{sub 0} during the beam-on time t{sub 0}.

  16. Transmural distribution of metabolic abnormalities and glycolytic activity during dobutamine-induced demand ischemia.

    PubMed

    Jameel, Mohammad N; Wang, Xiaohong; Eijgelshoven, Marcel H J; Mansoor, Abdul; Zhang, Jianyi

    2008-06-01

    The heterogeneity across the left ventricular wall is characterized by higher rates of oxygen consumption, systolic thickening fraction, myocardial perfusion, and lower energetic state in the subendocardial layers (ENDO). During dobutamine stimulation-induced demand ischemia, the transmural distribution of energy demand and metabolic markers of ischemia are not known. In this study, hemodynamics, transmural high-energy phosphate (HEP), 2-deoxyglucose-6-phosphate (2-DGP) levels, and myocardial blood flow (MBF) were determined under basal conditions, during dobutamine infusion (DOB: 20 microg x kg(-1) x min(-1) iv), and during coronary stenosis + DOB + 2-deoxyglucose (2-DG) infusion. DOB increased rate pressure products (RPP) and MBF significantly without affecting the subendocardial-to-subepicardial blood flow ratio (ENDO/EPI) or HEP levels. During coronary stenosis + DOB + 2-DG infusion, RPP, ischemic zone (IZ) MBF, and ENDO/EPI decreased significantly. The IZ ratio of creatine phosphate-to-ATP decreased significantly [2.30 +/- 0.14, 2.06 +/- 0.13, and 2.04 +/- 0.11 to 1.77 +/- 0.12, 1.70 +/- 0.11, and 1.72 +/- 0.12 for EPI, midmyocardial (MID), and ENDO, respectively], and 2-DGP accumulated in all layers, as evidenced by the 2-DGP/PCr (0.55 +/- 0.12, 0.52 +/- 0.10, and 0.37 +/- 0.08 for EPI, MID, and ENDO, respectively; P < 0.05, EPI > ENDO). In the IZ the wet weight-to-dry weight ratio was significantly increased compared with the normal zone (5.9 +/- 0.5 vs. 4.4 +/- 0.4; P < 0.05). Thus, in the stenotic perfused bed, during dobutamine-induced high cardiac work state, despite higher blood flow, the subepicardial layers showed the greater metabolic changes characterized by a shift toward higher carbohydrate metabolism, suggesting that a homeostatic response to high-cardiac work state is characterized by more glucose utilization in energy metabolism. PMID:18424629

  17. SU-E-T-533: Evaluation of Dose Calculation Accuracy for Small Elongated Targets On the Edge Linac

    SciTech Connect

    Qin, Y; Wen, N; Snyder, K; Huang, Y; Zhao, B; Bellon, M; Li, H; Song, K; Kim, J; Gordon, J; Chetty, I

    2014-06-01

    Purpose: To evaluate output factors and dose calculation accuracy on a novel SRS linear accelerator, the Edge (Varian), for treatments of small, elongated targets using flattening filter free (FFF) beam. Methods: Total scatter/output factors (OF’s) for 24 elongated, small, high definition multi-leaf collimator (HDMLC)-defined fields were measured on the Edge machine using 6X FFF beam. 3 detectors were used in water tank: CC01 ion chamber (active volume 10cc), stereotactic photon diode (SFD) (active diameter 0.6mm, active thickness 0.06mm), Edge detector (active volume 0.0019cc). The 24 MLC apertures have widths ranging from 5 to 20mm and length/width ratio from 0.25 to 5. Readings were cross calibrated with CC04 at field size 3×3 cm. A beam model was developed using commissioning measurements for treatment planning in Eclipse (AAA, version 11). One representative patient case (IMRT, target volume 0.2cc, 4×4×14mm) was calculated using AAA 11 and delivered on the Edge. Results: Due to volume averaging effects, CC01 readings were 11.2±0.9% lower than SFD readings for 5mm field sizes. The Edge diode showed a uniform over-response of 2.6±0.7% compared to SFD. Calculation using AAA v11 showed the best agreement with SFD measurements (2.4±1.7% lower than SFD). The largest difference between AAA v11 and SFD occurs at 5mm field sizes. For the patient plan, dose delivered on Edge was measured to be 2.2% higher than AAA v11 calculation. Conclusion: Cross-calibrated SFD output measurements presented the best agreement with commissioned AAA v11 beam model. Field sizes smaller than 1cm posed challenges to both the detectors and the calculation algorithm. For the representative patient with small elongated target, AAA v11 and measurements agreed within ~2% on the Edge linac. Although encouraging, a more comprehensive study is required to validate the overall algorithmic accuracy.

  18. Isomonodromic deformations and SU 2-invariant instantons on S4

    NASA Astrophysics Data System (ADS)

    Manasliski, Richard Muñiz

    2009-07-01

    Anti-self-dual (ASD) solutions to the Yang-Mills equation (or instantons) over an anti-self-dual 4-manifold, which are invariant under an appropriate action of a three-dimensional Lie group, give rise, via twistor construction, to isomonodromic deformations of connections on CP having four simple singularities. As is well known, such deformations are governed by the sixth Painlevé equation P VI(α,β,γ,δ). We work out the particular case of the SU-action on S4, obtained from the irreducible representation on R5. In particular, we express the parameters (α,β,γ,δ) in terms of the instanton number. The present paper contains the proof of the result announced in [Richard Muñiz Manasliski, Painlevé VI equation from invariant instantons, in: Geometric and Topological Methods for Quantum field theory, Contemp. Math., vol. 434, Amer. Math. Soc., Providence, RI, 2007, pp. 215-222].

  19. Ring state for single transition metal atoms on boron nitride on Rh(111).

    PubMed

    Natterer, Fabian Donat; Patthey, François; Brune, Harald

    2012-08-10

    The low-temperature adsorption of isolated transition metal adatoms (Mn, Co, and Fe) onto hexagonal boron nitride monolayers on Rh(111) creates a bistable adsorption complex. The first state considerably weakens the hexagonal boron nitride- (h-BN-) substrate bond for 60 BN unit cells, leading to a highly symmetric ring in STM images, while the second state is imaged as a conventional adatom and leaves the BN-substrate interaction intact. We demonstrate reversible switching between the two states and, thus, controlled pinning and unpinning of the h-BN layer from the metal substrate. I(z) and d lnI/dz curves are used to reveal the BN deformation in the ring state. PMID:23006283

  20. The effects of selected pre-treatments on germination of seeds of Oriental hornbeam (Carpinus orientalis).

    PubMed

    Ozel, Halil Bariş

    2016-07-01

    In the present study, the effect of some pre-treatments implemented on seeds of Oriental hornbeam (Carpinus orientalis), which has wide geographical variation along Turkey on germination percentage values were investigated. For this purpose, 13 different pre-treatments were implemented to seeds obtained from 17 different populations. According to the obtained results (except control seeds), pre-treatments leading to lowest germination percentage value (8.1%) in Oriental hornbeam seeds was PT10: Keeping seeds for 90 min in sulfuric acid, while highest germination percentage (86.58%) has been obtained with pre-treatment PT13: Implementation of 40% dose of Baikal EM1 + Biohoumous mixture to the seeds, while lowest germination percentage (40.50%) was observed on seeds collected from P7 (Bartin-Kozcağiz) population, highest germination percentage was observed in seeds obtained from P17 (Artvin-Hopa) population. PMID:27498493

  1. Synthesis of indoles from pyridinium salts

    SciTech Connect

    Gromov, S.P.; Bkhaumik, M.M.; Bundel', Yu.G.

    1987-10-01

    The detailed analysis of the products of the interaction of nitropyridinium salts with ketones and alkylamines resulted in new data testifying in favor of the previously proposed scheme for the formation of indoles from pyridinium salts. The PMR spectra were taken on a Bruker WM-500 spectrometer for the compounds (IXa,b) in CDCl/sub 3/, and (IVg, i-Z) in acetone-D/sub 6/, and a Varian T-60 spectrometer for the alkylindoles (IVa,c,h) in CDCl/sub 3/, with reference to HMDS. The /sup 13/C NMR spectra were taken on a Bruker WM-250 spectrometer in CDCl/sub 3/. The mass spectra were taken on a Finnigan-4021 instrument.

  2. The CMC/3DPNS computer program for prediction of three-dimensional, subsonic, turbulent aerodynamic juncture region flow. Volume 3: Programmers' manual

    NASA Technical Reports Server (NTRS)

    Orzechowski, J. A.

    1982-01-01

    The CMC fluid mechanics program system was developed to transmit the theoretical evolution of finite element numerical solution methodology, applied to nonlinear field problems into a versatile computer code for comprehensive flow field analysis. A detailed view of the code from the standpoint of a computer programmer's use is presented. A system macroflow chart and detailed flow charts of several routines necessary to interact with a theoretican/user to modify the operation of this program are presented. All subroutines and details of usage, primarily for input and output routines are described. Integer and real scalars and a cross reference list denoting subroutine usage for these scalars are outlined. Entry points in dynamic storage vector IZ; the lengths of each vector accompanying the scalar definitions are described. A listing of the routines peculiar to the standard test case and a listing of the input deck and printout for this case are included.

  3. [Inhibition of NF-kB Activation Decreases Resistance in Acute Myeloid Leukemia Cells to TRAIL-induced Apoptosis in Multicellular Aggregates].

    PubMed

    Fadeev, R S; Solovieva, M E; Slyadovskiy, D A; Zakharov, S G; Fadeeva, I S; Senotov, A S; Golenkov, A K; Akatov, V S

    2015-01-01

    Suppression of resistance in acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates, was studied using small molecule inhibitors of the activation of the transcription factor NF-kB - NF-k9 Activation Inhibitor IV and JSH-23 at non-toxic concentrations. NF-kB Activation Inhibitor IV and JSH-23 reduced resistance in the acute myeloid leukemia cells in multicellular aggregates to cytotoxic action of recombinant protein izTRAIL. It is shown that the use of these inhibitors decreased the phosphorylation of the RelA (p65) as a main marker activation of the transcription factor NF-kB. We discuss a possible reason for increasing resistance in acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates. PMID:26841509

  4. Machine Learning Search for Gamma-Ray Burst Afterglows in Optical Images

    NASA Astrophysics Data System (ADS)

    Topinka, M.

    2016-06-01

    Thanks to the advances in robotic telescopes, time domain astronomy leads to a large number of transient events detected in images every night. Data mining and machine learning tools used for object classification are presented. The goal is to automatically classify transient events for both further follow-up by a larger telescope and for statistical studies of transient events. Special attention is given to the identification of gamma-ray burst afterglows. Machine learning techniques are used to identify GROND gamma-ray burst afterglow among the astrophysical objects present in the SDSS archival images based on the g'-r', r'-i' and i'-z' color indices. The performance of the support vector machine, random forest and neural network algorithms is compared. A joint meta-classifier, built on top of the individual classifiers, can identify GRB afterglows with the overall accuracy of ≳ 90%.

  5. Taxonomy of the genus Diochus Erichson, 1839 (Coleoptera: Staphylinidae, Staphylininae, Diochini) in China with descriptions of four new species.

    PubMed

    Zhou, Yu-Lingzi; Zhou, Hong-Zhang

    2016-01-01

    This paper studies the taxonomy of the genus Diochus Erichson, 1839 (Coleoptera: Staphylinidae, Staphylininae, Diochini) from China. Four new species are described: Diochus bicornutus sp. nov. from Fujian, Hainan, Zhejiang, Guangxi and Yunnan, D. ampullaceus sp. nov. from Guangxi, D. bisegmentatus sp. nov. from Hainan and Yunnan, and D. membranaceus sp. nov. from Fujian. All other species previously reported from China are redescribed based on the examination of the holotypes, except the holotype of D. antennatus (Motschulsky, 1858), which was missing. Line drawings of the now missing holotype of D. antennatus (Motschulsky, 1858) are provided. A lectotype is designated for D. conicollis (Motschulsky, 1858). The Chinese fauna of the genus Diochus is now represented by eight species (four doubtfully recorded) and a key to all the Chinese species is provided. The type specimens of the new species are deposited in the Institute of Zoology, Chinese Academy of Sciences (IZ-CAS). PMID:27395610

  6. Giant tunneling anomalous Hall conductance in topological insulators

    NASA Astrophysics Data System (ADS)

    Matos-Abiague, Alex; Scharf, Benedikt; Han, Jong E.; Hankiewicz, Ewelina M.; Zutic, Igor

    We theoretically investigate the tunneling transport across a magnetic barrier modulated by a top gate potential on the surface of a three-dimensional topological insulator. In the presence of a magnetization component along the bias direction, a finite tunneling anomalous Hall conductance (TAHC), transverse to the applied bias, develops. Depending on the strengths of the magnetization and gate potential, the system can exhibit a giant anomalous Hall angle, with the TAHC exceeding the longitudinal tunneling conductance. Moreover, we predict the existence of a negative differential TAHC even when the longitudinal differential conductance remains positive. This work was supported by U.S. ONR Grant No. N000141310754 (A.M.-A., B.S.), DFG Grant No. SCHA 1899/1-1 (B.S.), DFG Grant No. HA 5893/4-1 within SPP 1666 (E.M.H.), and U.S. DOE, Office of Science BES, under Award DE-SC0004890 (I.Z.).

  7. Tunneling Seebeck and Anomalous Nernst effects in three-dimensional topological insulators

    NASA Astrophysics Data System (ADS)

    Shen, Chenghao; Scharf, Benedikt; Matos-Abiague, Alex; Zutic, Igor

    We theoretically investigate the longitudinal (Seebeck) and transverse (Nernst) thermopowers generated by thermally-induced tunneling across a magnetic barrier on the surface of a three-dimensional insulator. As a manifestation of Klein tunneling, the tunneling Seebeck coefficient exhibits oscillatory behavior with respect to the barrier thickness. Moreover, in spite of the absence of a source of spin polarization (only the barrier is magnetic), the tunneling anomalous Nernst coefficient is not only finite but can even be much larger than its Seebeck counterpart. This work was supported by DFG Grant No. SCHA 1899/1-1 (B.S.), U.S. ONR Grant No. N000141310754 (B.S., A.M.-A.), U.S. DOE, Office of Science BES, under Award DE-SC0004890 (I.Z.).

  8. Comparison of Transition Metal-Mediated Oxidation Reactions of Guanine in Nucleoside and Single-Stranded Oligodeoxynucleotide Contexts

    PubMed Central

    Ghude, Pranjali; Schallenberger, Mark A.; Fleming, Aaron M.; Muller, James G.; Burrows, Cynthia J.

    2011-01-01

    As the most readily oxidized of DNA’s four natural bases, guanine is a prime target for attack by reactive oxygen species (ROS) and transition metal-mediated oxidants. The oxidation products of a modified guanosine nucleoside and of a single-stranded oligodeoxynucleotide, 5′-d(TTTTTTTGTTTTTTT)-3′ have been studied using oxidants that include CoII, NiII, and IrIV compounds as well as photochemically generated oxidants such as sulphate radical, electron-transfer agents (riboflavin) and singlet oxygen. The oxidized lesions formed include spiroiminodihydantoin (Sp), guanidinohydantoin (Gh), imidazolone (Iz), oxazolone (Z) and 5-carboxamido-5-formamido-2-iminohydantion (2-Ih) nucleosides with a high degree of dependence on the exact oxidation system employed. Interestingly, a nickel(II) macrocyclic complex in conjunction with KHSO5 leads to the recently reported 2-Ih heterocycle as the major product in both the nucleoside and oligonucleotide contexts. PMID:21516189

  9. The Hopf cyclicity of the centers of a class of quintic polynomial vector fields

    NASA Astrophysics Data System (ADS)

    García, Isaac A.; Llibre, Jaume; Maza, Susanna

    2015-03-01

    We consider families of planar polynomial vector fields having a singularity with purely imaginary eigenvalues for which a basis of its Bautin ideal B is known. We provide an algorithm for computing an upper bound of the Hopf cyclicity less than or equal to the Bautin depth of B. We also present a method for studying the cyclicity problem for the Hamiltonian and the time-reversible centers without the necessity of solving previously the Dulac complex center problem associated to the larger complexified family. As application we analyze the Hopf cyclicity of the quintic polynomial family written in complex notation as z ˙ = iz + z z bar (Az3 + Bz2 z bar + Czzbar2 + Dzbar3).

  10. DNA damage by the sulfate radical anion: hydrogen abstraction from the sugar moiety versus one-electron oxidation of guanine.

    PubMed

    Roginskaya, Marina; Mohseni, Reza; Ampadu-Boateng, Derrick; Razskazovskiy, Yuriy

    2016-07-01

    The products of oxidative damage to double-stranded (ds) DNA initiated by photolytically generated sulfate radical anions SO4(•-) were analyzed using reverse-phase (RP) high-performance liquid chromatography (HPLC). Relative efficiencies of two major pathways were compared: production of 8-oxoguanine (8oxoG) and hydrogen abstraction from the DNA 2-deoxyribose moiety (dR) at C1,' C4,' and C5' positions. The formation of 8oxoG was found to account for 87% of all quantified lesions at low illumination doses. The concentration of 8oxoG quickly reaches a steady state at about one 8oxoG per 100 base pairs due to further oxidation of its products. It was found that another guanine oxidation product identified as 2-amino-5-(2'-alkylamino)-4H-imidazol-4-one (X) was released in significant quantities from its tentative precursor 2-amino-5-[(2'-deoxy-β-d-erythro-pentofuranosyl)amino]-4H-imidazol-4-one (dIz) upon treatment with primary amines in neutral solutions. The linear dose dependence of X release points to the formation of dIz directly from guanine and not through oxidation of 8oxoG. The damage to dR was found to account for about 13% of the total damage, with majority of lesions (33%) originating from the C4' oxidation. The contribution of C1' oxidation also turned out to be significant (17% of all dR damages) despite of the steric problems associated with the abstraction of the C1'-hydrogen. However, no evidence of base-to-sugar free valence transfer as a possible alternative to direct hydrogen abstraction at C1' was found. PMID:27043476

  11. SPITZER TRANSITS OF THE SUPER-EARTH GJ1214b AND IMPLICATIONS FOR ITS ATMOSPHERE

    SciTech Connect

    Fraine, Jonathan D.; Deming, Drake; Gillon, Michaeel; Jehin, Emmanueel; Demory, Brice-Olivier; Benneke, Bjoern; Seager, Sara; Lewis, Nikole K.; Knutson, Heather; Desert, Jean-Michel

    2013-03-10

    We observed the transiting super-Earth exoplanet GJ1214b using warm Spitzer at 4.5 {mu}m wavelength during a 20 day quasi-continuous sequence in 2011 May. The goals of our long observation were to accurately define the infrared transit radius of this nearby super-Earth, to search for the secondary eclipse, and to search for other transiting planets in the habitable zone of GJ1214. We here report results from the transit monitoring of GJ1214b, including a reanalysis of previous transit observations by Desert et al. In total, we analyze 14 transits of GJ1214b at 4.5 {mu}m, 3 transits at 3.6 {mu}m, and 7 new ground-based transits in the I+z band. Our new Spitzer data by themselves eliminate cloudless solar composition atmospheres for GJ1214b, and methane-rich models from Howe and Burrows. Using our new Spitzer measurements to anchor the observed transit radii of GJ1214b at long wavelengths, and adding new measurements in I+z, we evaluate models from Benneke and Seager and Howe and Burrows using a {chi}{sup 2} analysis. We find that the best-fit model exhibits an increase in transit radius at short wavelengths due to Rayleigh scattering. Pure water atmospheres are also possible. However, a flat line (no atmosphere detected) remains among the best of the statistically acceptable models, and better than pure water atmospheres. We explore the effect of systematic differences among results from different observational groups, and we find that the Howe and Burrows tholin-haze model remains the best fit, even when systematic differences among observers are considered.

  12. Evaluation of a competitive ELISA for antibody detection against avian influenza virus.

    PubMed

    Song, Dae Sub; Lee, Youn Jeong; Jeong, Ok Mi; Kim, Yong Joo; Park, Chan Hee; Yoo, Jung Eun; Jeon, Woo Jin; Kwon, Jun Hun; Ha, Gun Woo; Kang, Bo Kyu; Lee, Chul Seung; Kim, Hye Kwon; Jung, Byeong Yeal; Kim, Jae Hong; Oh, Jin Sik

    2009-12-01

    Active serologic surveillance is necessary to control the spread of the avian influenza virus (AIV). In this study, we evaluated a commercially-available cELISA in terms of its ability to detect AIV antibodies in the sera of 3,358 animals from twelve species. cELISA detected antibodies against reference H1- through H15-subtype AIV strains without cross reactivity. Furthermore, the cELISA was able to detect antibodies produced following a challenge of the AIV H9N2 subtype in chickens, or following vaccination of the AIV H9 or H5 subtypes in chickens, ducks and geese. Next, we tested the sensitivity and specificity of the cELISA with sera from twelve different animal species, and compared these results with those obtained by the hemagglutination-inhibition (HI) test, the "gold standard" in AIV sera surveillance, a second commercially-available cELISA (IZS ELISA), or the agar gel precipitation (AGP) test. Compared with the HI test, the sensitivities and specificities of cELISA were 95% and 96% in chicken, 86% and 88% in duck, 97% and 100% in turkey, 100% and 87% in goose, and 91% and 97% in swine, respectively. The sensitivities and specificities of the cELISA in this study were higher than those of IZS ELISA for the duck, turkey, goose, and grey partridge sera samples. The results of AGP test against duck and turkey sera also showed significant correlation with the results of cELISA (R-value >0.9). In terms of flock sensitivity, the cELISA correlated better with the HI test than with commercially-available indirect ELISAs, with 100% flock sensitivity. PMID:19934598

  13. Mass flows of perfluorinated compounds (PFCs) in central wastewater treatment plants of industrial zones in Thailand.

    PubMed

    Kunacheva, Chinagarn; Tanaka, Shuhei; Fujii, Shigeo; Boontanon, Suwanna Kitpati; Musirat, Chanatip; Wongwattana, Thana; Shivakoti, Binaya Raj

    2011-04-01

    Perfluorinated compounds (PFCs) are fully fluorinated organic compounds, which have been used in many industrial processes and have been detected in wastewater and sludge from municipal wastewater treatment plants (WWTPs) around the world. This study focused on the occurrences of PFCs and PFCs mass flows in the industrial wastewater treatment plants, which reported to be the important sources of PFCs. Surveys were conducted in central wastewater treatment plant in two industrial zones in Thailand. Samples were collected from influent, aeration tank, secondary clarifier effluent, effluent and sludge. The major purpose of this field study was to identify PFCs occurrences and mass flow during industrial WWTP. Solid-phase extraction (SPE) coupled with HPLC-ESI-MS/MS were used for the analysis. Total 10 PFCs including perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluoropropanoic acid (PFPA), perfluorohexanoic acid (PFHxA), perfluoroheptanoic acid (PFHpA), perfluorohexane sulfonate (PFHxS), perfluoronanoic acid (PFNA), perfluordecanoic acid (PFDA), perfluoroundecanoic acid (PFUnA), and perfluorododecanoic acid (PFDoA) were measured to identify their occurrences. PFCs were detected in both liquid and solid phase in most samples. The exceptionally high level of PFCs was detected in the treatment plant of IZ1 and IZ2 ranging between 662-847ngL(-1) and 674-1383ngL(-1), respectively, which greater than PFCs found in most domestic wastewater. Due to PFCs non-biodegradable property, both WWTPs were found ineffective in removing PFCs using activated sludge processes. Bio-accumulation in sludge could be the major removal mechanism of PFCs in the process. The increasing amount of PFCs after activated sludge processes were identified which could be due to the degradation of PFCs precursors. PFCs concentration found in the effluent were very high comparing to those in river water of the area. Industrial activity could be the one of major sources of PFCs

  14. Therapeutic value of lymph node dissection for right middle lobe non-small-cell lung cancer

    PubMed Central

    Kuroda, Hiroaki; Mun, Mingyon; Motoi, Noriko; Ishikawa, Yuichi; Nakagawa, Ken; Yatabe, Yasushi; Okumura, Sakae

    2016-01-01

    Background Superior mediastinal and #11i lymph node (LN) metastases are adverse prognostic factors in patients with middle lobe lung cancer. We aimed to clarify the benefit of thorough lymphadenectomy by LN station or zone in middle lobe non-small-cell lung cancer (NSCLC). Methods Among 295 patients who underwent pulmonary resection and thorough lymphadenectomy for primary right middle lobe (RML) NSCLC at two institutions, we enrolled 68 patients (33 men, 35 women) and retrospectively studied their data. We divided each N1 location (i.e., #10, #11s and #11i) into N1(−)N2(+) and N1(+)N2(+) and divided the #12m location into N1(+)N2(−), N1(−)N2(+) and N1(+)N2(+). Results Interlobar node involvement was rare in pN1 NSCLC when compared with that in other N1 nodes. Lymph node dissection (LND) was beneficial when the hilar zone (HZ)/interlobar zone (IZ) LNs were located at the intermediate point of the upper zones (UZs) and subcarinal zones (SCZs), with the therapeutic benefit at the SCZ being 2.8-fold higher than that at the UZ and 9.7-fold higher than that at the lower zone (LZ). Furthermore, LND evidently had greater therapeutic value for the SCZ than the UZ, which was compatible with skip N2 metastases. Conclusions For middle lobe NSCLC, mediastinal LND should be considered a priority in the SCZ than in the UZ. Moreover, the HZ/IZ is central to unfavourable prognoses in patients with pN2 middle lobe NSCLC. PMID:27162652

  15. Effects of maternal mild zinc deficiency and different ways of zinc supplementation for offspring on learning and memory

    PubMed Central

    Yu, Xiaogang; Chen, Weiwei; Wei, Zhenzhen; Ren, Tianhong; Yang, Xin; Yu, Xiaodan

    2016-01-01

    Background The effect of different ways of zinc supplementation on spatial learning and memory remains unclear. Objectives This study aims to assess the effectiveness of two ways of zinc supplementation – oral use and intravenous transfusion – in zinc-deficient offspring rats on learning and memory. Design Rats were randomly divided into six groups on the first day of pregnancy (n=12): control (CO), pair fed (PF), zinc deprived (ZD), oral zinc supplementation (OZS), injection zinc supplementation (IZS), and injection control. The offspring's spatial learning and memory were tested at postnatal day 35 using Morris water maze (MWM). Maternal rats’ serum zinc was measured at postnatal day 21, while pups’ serum zinc was measured at postnatal day 35. Results Compared with the CO and PF groups, pups in ZD group spent more time finding the latent platform and swam longer distances (p<0.05). Compared with ZD groups, pups in OZS group significantly decreased the time used for finding the platform and the swimming distance (p<0.05) and were similar to that of CO and PF groups (p>0.05). However, compared with ZD groups, pups in IZS did not show any improvement in the indexes of MWM (p>0.05) although their zinc serum concentration increased significantly (p<0.05). Conclusions These results indicate that mild zinc deficiency during pregnancy and lactation leads to the impairment of learning and memory function in offspring, and that OZS, instead of intravenous transfusion zinc supplementation, can recover the impairment of spatial learning and memory function. PMID:26829185

  16. Correlating Photoreceptor Mosaic Structure to Clinical Findings in Stargardt Disease

    PubMed Central

    Razeen, Moataz M.; Cooper, Robert F.; Langlo, Christopher S.; Goldberg, Mara R.; Wilk, Melissa A.; Han, Dennis P.; Connor, Thomas B.; Fishman, Gerald A.; Collison, Frederick T.; Sulai, Yusufu N.; Dubra, Alfredo; Carroll, Joseph; Stepien, Kimberly E.

    2016-01-01

    Purpose To demonstrate a method for correlating photoreceptor mosaic structure with optical coherence tomography (OCT) and microperimetry findings in patients with Stargardt disease. Methods A total of 14 patients with clinically diagnosed Stargardt disease were imaged using confocal and split-detection adaptive optics scanning light ophthalmoscopy. Cone photoreceptors were identified manually in a band along the temporal meridian. Resulting values were compared to a normative database (n = 9) to generate cone density deviation (CDD) maps. Manual measurement of outer nuclear layer plus Henle fiber layer (ONL+HFL) thickness was performed, in addition to determination of the presence of ellipsoid zone (EZ) and interdigitation zone (IZ) bands on OCT. These results, along with microperimetry data, were overlaid with the CDD maps. Results Wide variation in foveal structure and CDD maps was seen within this small group. Disruption of ONL+HFL and/or IZ band was seen in all patients, with EZ band preservation in regions with low cone density in 38% of locations analyzed. Normality of retinal lamellar structure on OCT corresponded with cone density and visual function at 50/78 locations analyzed. Outer retinal tubulations containing photoreceptor-like structures were observed in 3 patients. Conclusions The use of CDD color-coded maps enables direct comparison of cone mosaic local density with other measures of retinal structure and function. Larger normative datasets and improved tools for automation of image alignment are needed. Translational Relevance The approach described facilitates comparison of complex multimodal data sets from patients with inherited retinal degeneration, and can be expanded to incorporate other structural imaging or functional testing. PMID:26981328

  17. [Multidrug-resistant tuberculosis associated with AIDS (kinetics of nosocomial epidemics of multidrug-resistant tuberculosis associated with AIDS. Possible transformation into endemic disease].

    PubMed

    Gonzàlez Montaner, L J; Alberti, F; Palmero, D

    1999-01-01

    The increase in the incidence of AIDS-related tuberculosis over the last decades has fueled the dissemination of multiple drug resistance tuberculosis (including resistant strains to INH and rifampin). This has now been recognized in a variety of settings including hospitals, prisons and shelters. We have identified a nosocomial epidemic at the Muñiz Hospital in the city of Buenos Aires, Argentina. This has evolved as one of the largest institutional outbreaks yet to be recognized. The purpose of this paper is to characterize the evolution of this outbreak which at the end of 1997 had involved in excess of 500 cases. Among the 3,322 patients discharged at the Muñiz Hospital during the years 1996-1997 with the diagnosis of tuberculosis, 440 (13.24%) were discharged with the diagnosis of multiple drug resistance tuberculosis. The immediate mortality (during the ensuing four months following the bacteriological diagnosis) was of 91.3% of cases in 1995 and decreased progressively to 65.9% in 1996 and 55.9% in 1997. The bacteriological confirmation of the diagnosis was made after the patients death in a decreasing number of cases, going from 72.5% of the cases in 1995 to 28.3% of the cases in 1997. Despite the significant progress achieved with regard to the diagnosis and treatment of multiple drug resistance tuberculosis, the measures undertaken to decrease the spread of the cases have had limited success. This is chiefly attributable to the inability to isolate cases. This has continued to promote nosocomial spread of multiple drug resistance tuberculosis in our environment. PMID:10560164

  18. Method of separation of celestial gamma-ray bursts from solar flares

    SciTech Connect

    Chuang, K.W.; White, R.S. ); Klebesadel, R.W.; Laros, J.G. )

    1991-09-01

    We recently discovered 217 new'' celestial gamma-ray burst candidates from the new'' burst search of the PVO real time data base.[sup 1] The burst search covered the time period from September 1978 to July 1988. Sixty were confirmed by at lest on other spacecraft, e.g., ISEE-3, V-11, V-12, etc. None triggered the PVO high time resolution memory. In this paper we describe a new algorithm based ont eh relationship between time width [ital T][sub [ital w

  19. Absolute np and pp cross section determinations aimed at improving the standard for cross section measurements

    SciTech Connect

    Laptev, Alexander B; Haight, Robert C; Tovesson, Fredrik; Arndt, Richard A; Briscoe, William J; Paris, Mark W; Strakovsky, Igor I; Workman, Ron L

    2010-01-01

    Purpose of present research is a keeping improvement of the standard for cross section measurements of neutron-induced reactions. The cross sections for np and pp scattering below 1000 MeV are determined based on partial-wave analyses (PW As) of nucleon-nucleon scattering data. These cross sections are compared with the most recent ENDF/B-V11.0 and JENDL-4.0 data files, and the Nijmegen PWA. Also a comparison of evaluated data with recent experimental data was made to check a quality of evaluation. Excellent agreement was found between the new experimental data and our PWA predictions.

  20. Additional new minor cucurbitane glycosides from Siraitia grosvenorii.

    PubMed

    Prakash, Indra; Chaturvedula, Venkata Sai Prakash

    2014-01-01

    Continuous phytochemical studies of the crude extract of Luo Han Guo (Siraitia grosvenorii) furnished three additional new cucurbitane triterpene glycosides, namely 11-deoxymogroside V, 11-deoxyisomogroside V, and 11-deoxymogroside VI. The structures of all the isolated compounds were characterized on the basis of extensive NMR and mass spectral data as well as hydrolysis studies. The complete ¹H- and ¹³C-NMR spectral assignments of the three unknown compounds are reported for the first time based on COSY, TOCSY, HSQC, and HMBC spectroscopic data. PMID:24662081

  1. Stable large-scale CO2 storage in defiance of an energy system based on renewable energy - Modelling the impact of varying CO2 injection rates on reservoir behavior

    NASA Astrophysics Data System (ADS)

    Bannach, Andreas; Hauer, Rene; Martin, Streibel; Stienstra, Gerard; Kühn, Michael

    2015-04-01

    The IPCC Report 2014 strengthens the need for CO2 storage as part of CCS or BECCS to reach ambitious climate goals despite growing energy demand in the future. The further expansion of renewable energy sources is a second major pillar. As it is today in Germany the weather becomes the controlling factor for electricity production by fossil fuelled power plants which lead to significant fluctuations of CO2-emissions which can be traced in injection rates if the CO2 were captured and stored. To analyse the impact of such changing injection rates on a CO2 storage reservoir. two reservoir simulation models are applied: a. An (smaller) reservoir model approved by gas storage activities for decades, to investigate the dynamic effects in the early stage of storage filling (initial aquifer displacement). b. An anticline structure big enough to accommodate a total amount of ≥ 100 Mega tons CO2 to investigate the dynamic effects for the entire operational life time of the storage under particular consideration of very high filling levels (highest aquifer compression). Therefore a reservoir model was generated. The defined yearly injection rate schedule is based on a study performed on behalf of IZ Klima (DNV GL, 2014). According to this study the exclusive consideration of a pool of coal-fired power plants causes the most intensive dynamically changing CO2 emissions and hence accounts for variations of a system which includes industry driven CO2 production. Besides short-term changes (daily & weekly cycles) seasonal influences are also taken into account. Simulation runs cover a variation of injection points (well locations at the top vs. locations at the flank of the structure) and some other largely unknown reservoir parameters as aquifer size and aquifer mobility. Simulation of a 20 year storage operation is followed by a post-operational shut-in phase which covers approximately 500 years to assess possible effects of changing injection rates on the long-term reservoir

  2. VizieR Online Data Catalog: Dynamical parameters of open clusters (Danilov+, 2012)

    NASA Astrophysics Data System (ADS)

    Danilov, V. M.; Putkov, S. I.

    2012-11-01

    α0 - is the mean value of a virial factor, δ{alp the amplitude of virial factor oscillations, ν={rho}c/{rho}0-is the density contrast ({rho}c - is the mean density of a cluster core, {rho}0 - is the cluster centre density), NK/N - is the ratio of the stars number in a cluster received by King's distribution and by stellar counts, P1-is the period of cluster core oscillations, P2 - is the period of cluster oscillations, δR1/R10-is the relative amplitude of core radius oscillations, λ=σ/σiz, σiz2 - is the velocity dispersion of an isolated virialized cluster, σ2, σ12, σ22 - are the velocity dispersions of nonisolated nonsteady clusters with spherical halo; with ellipsoidal halo elongated to the centre of Galaxy; with ellipsoidal halo elongated to the direction of cluster motion correspondingly. Errors of values α0, δα, δR1/R10, P1 have been estimated by the assumption of the normal distribution of the values M (the mass of a cluster), R2 (the radius of a cluster), {xi} (the ratio of core radius to halo radius), μ (the ratio of core mass to halo mass). Assuming a deviation of one of the four values equal to zero we receive four sections of 1σ-errors ellipsoid. These sections are the spheres of radius 20.5. Taking points on each sphere with the step 0.25*π on angular coordinates we receive 96 points on a surface of the 1σ-errors ellipsoid. The values α0, δα, δR1/R10, P1 were calculated in the 96 points. The centre of the ellipsoidal was used for calculation of the mean values. The errors of the values were computed as root-mean-squire deviations of 96 values from the same mean values. The errors of the others values of the catalog were computed by the errors calculation rule of indirect measuring. (3 data files).

  3. Explosively erupted magmas with relatively quiescent differentiation stories. Examples from Sierra Nevada, México

    NASA Astrophysics Data System (ADS)

    Sosa-Ceballos, G.; Macias, J.; Garduño-Monroy, V. H.

    2013-12-01

    Sierra Nevada is a N-S aligned volcanic range in central Mexico, located approximately 65 km SE of Mexico City. It is formed by Telapón, Tláloc, Iztaccíhuatl, and Popocatépetl volcanoes. Popocatepetl have had at least five Plinian eruptions in the last 23 ky and at least two sector collapses that partially destroyed the volcanic edifice. Iztaccíhuatl explosive history is less constrained than Popocatepetl's but a debris avalanche deposit suggest that at least one sector collapse affected the volcano. The most recent debris avalanche deposits from Popocatépetl (23 ky) and Iztaccíhuatl (430 ky) are crowned by fall deposits produced by an explosive eruption. Compared to the other Plinian magmas from Popocatepetl, the WP magma (Popocatepetl) and the IZ-4 magma (Iztaccíhuatl) are slightly more evolved (65-66 wt. % SiO2), do not contain any xenocryst suggesting mixing with more mafic magmas (olivine, Mg-rich pyroxene, or Cr-rich magnetite), their frequency of mixing events is lower, disequilibrium textures like sieving are absent, and at least for the WP magma, evidence of upper crust assimilation is negligible. In addition, equilibrium of Fe-Ti oxides, CO2 and water concentrations analyzed in melt inclusions, and hydrothermal experiments yield that the pre-eruptive conditions of both magmas are approximately ~910 °C and <200 MPa. The pressure of storage is greater compared to the other Plinain magmas from Popocatepetl, ~130 MPa. It is well known that magma mixing could trigger explosive eruptions. However, in contrast to all other Plinian eruptions from Popocatepetl, the WP and IZ-4 magmas seem to being predominately crystallizing with no major effects from mixing and/or assimilation, and that they were tapped just because of the effect produced on the pressure gradient by the sector collapse. This is important for present day monitoring of Popocatépetl activity, because it seems that the deeper reservoir is less prone for mixing and that the accumulation of

  4. Discrimination between Lumbar Intraspinal Stenosis and Foraminal Stenosis using Diffusion Tensor Imaging Parameters: Preliminary Results

    PubMed Central

    Ohtori, Seiji; Suzuki, Munetaka; Oikawa, Yasuhiro; Yamanaka, Hajime; Tamai, Hiroshi; Kobayashi, Tatsuya; Orita, Sumihisa; Yamauchi, Kazuyo; Suzuki, Miyako; Aoki, Yasuchika; Watanabe, Atsuya; Kanamoto, Hirohito; Takahashi, Kazuhisa

    2016-01-01

    Study Design Retrospective observational study. Purpose To examine fractional anisotropy (FA) values and apparent diffusion coefficient (ADC) values of damaged nerves to discriminate between lumbar intraspinal stenosis (IS) and foraminal stenosis (FS) using diffusion tensor imaging (DTI) Overview of Literature It is important in the selection of surgical procedure to discriminate between lumbar IS and FS, but such discrimination is difficult. Methods There were 9 cases of IS, 7 cases of FS, and 5 healthy controls. The regions of interest were established in the lumbar intraspinal zone (Iz), nerve root (N), and extraforaminal zone (Ez). The FA and ADC values were measured on the affected and unaffected sides of the nerves. The FA ratio and the ADC ratio were calculated as the affected side/unaffected side ×100 (%). Results In the Ez, the FA value was significantly lower in FS than in IS (p<0.01). FA ratio was significantly lower in FS than in IS for the Ez (p<0.01). In the Iz, the ADC value was significantly higher in IS than FS (p<0.01). ADC ratio was significantly higher in FS than in IS for the N and Ez (p<0.05). For the Ez, receiver operating characteristic analysis of parameters revealed that the FA values showed a higher accuracy for the diagnosis of FS than the ADC values, and the FA value cut-off value was 0.42 (sensitivity: 85.7%, false positive: 11.1%) and the FA ratio cut-off value was 83.9% (sensitivity: 85.7%, false positive: 22.2%). Conclusions The low FA value in the extraforaminal zone suggests the presence of foraminal stenosis. When the FA value and FA ratio cut-off value were established as 0.42 and 83.9%, respectively, the accuracy was high for the diagnosis of foraminal stenosis. It may be possible to use DTI parameters to help in the discrimination between IS and FS. PMID:27114775

  5. Structure prediction of Fe(II) 2-oxoglutarate dioxygenase from a psychrophilic yeast Glaciozyma antarctica PI12

    NASA Astrophysics Data System (ADS)

    Yusof, Nik Yusnoraini; Bakar, Farah Diba Abu; Mahadi, Nor Muhammad; Raih, Mohd Firdaus; Murad, Abdul Munir Abdul

    2015-09-01

    A cDNA encoding Fe(II) 2-oxoglutarate (2OG) dependent dioxygenases was isolated from psychrophilic yeast, Glaciozyma antarctica PI12. We have successfully amplified 1,029 bp cDNA sequence that encodes 342 amino acid with predicted molecular weight 38 kDa. The prediction protein was analysed using various bioinformatics tools to explore the properties of the protein. Based on a BLAST search analysis, the Fe2OX amino acid sequence showed 61% identity to the sequence of oxoglutarate/iron-dependent oxygenase from Rhodosporidium toruloides NP11. SignalP prediction showed that the Fe2OX protein contains no putative signal peptide, which suggests that this enzyme most probably localised intracellularly.The structure of Fe2OX was predicted by homology modelling using MODELLER9v11. The model with the lowest objective function was selected from hundred models generated using MODELLER9v11. Analysis of the structure revealed the longer loop at Fe2OX from G.antarctica that might be responsible for the flexibility of the structure, which contributes to its adaptation to low temperatures. Fe2OX hold a highly conserved Fe(II) binding HXD/E…H triad motif. The binding site for 2-oxoglutarate was found conserved for Arg280 among reported studies, however the Phe268 was found to be different in Fe2OX.

  6. Rapid Synthesis of a Near-β Titanium Alloy by Blended Elemental Powder Metallurgy (BEPM) with Induction Sintering

    NASA Astrophysics Data System (ADS)

    Jia, Mingtu; Gabbitas, Brian

    2015-10-01

    A near-β Ti-13V-11Cr-3Al alloy was produced by blended elemental powder metallurgy combining warm compaction and induction sintering. Two Ti-13V-11Cr-3Al powder compacts with different oxygen content were manufactured by mixing PREP and HDH Ti powders with Cr and AlV master alloy powders, respectively. The effect of isothermal holding time, at a sintering temperature of 1573 K (1300 °C), on pore characteristics and compositional homogeneity was investigated in this study. Pore coarsening by Ostwald ripening occurred with an increase in the isothermal holding time and Kirkendall voids were produced by a reaction between Ti and Cr. After an isothermal holding time of 10 minutes, the two sintered powder compacts had a homogeneous composition. Ti/AlV and Ti/Cr diffusion couples were used to predict the distribution of alloying elements, and the binary Ti-V, Ti-Al, and Ti-Cr interdiffusion coefficients were consistent with the distribution of alloying elements after isothermal holding. The mechanical properties of sintered powder compacts, prepared using PREP Ti powder as the raw powder, were optimized by sintered density and pore size.

  7. Lectin-binding properties of Aeromonas caviae strains

    PubMed Central

    Rocha-de-Souza, Cláudio M.; Hirata-Jr, Raphael; Mattos-Guaraldi, Ana L.; Freitas-Almeida, Angela C.; Andrade, Arnaldo F. B.

    2008-01-01

    The cell surface carbohydrates of four strains of Aeromonas caviae were analyzed by agglutination and lectin-binding assays employing twenty highly purified lectins encompassing all sugar specificities. With the exception of L-fucose and sialic acid, the sugar residues were detected in A. caviae strains. A marked difference, however, in the pattern of cell surface carbohydrates in different A. caviae isolates was observed. Specific receptors for Tritricum vulgaris (WGA), Lycopersicon esculentum (LEL) and Solanum tuberosum (STA) (D-GlcNAc-binding lectins) were found only in ATCC 15468 strain, whereas Euonymus europaeus (EEL, D-Gal-binding lectin) sites were present exclusively in AeQ32 strain, those for Helix pomatia (HPA, D-GalNAc-binding lectin) in AeC398 and AeV11 strains, and for Canavalia ensiformes (Con A, D-Man-binding lectin) in ATCC 15468, AeC398, AeQ32 and AeV11 strains, after bacterial growing at 37°C. On the other hand, specific receptors for WGA and EEL were completely abrogated growing the bacteria at 22°C. Binding studies with 125I- labeled lectins from WGA, EEL and Con A were performed. These assays essentially confirmed the selectivity, demonstrated in the agglutination assays of these lectins for the A. caviae strains. PMID:24031204

  8. Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection.

    PubMed

    Wang, Chao; Li, Xue; Yu, Fei; Lu, Lu; Jiang, Xifeng; Xu, Xiaoyu; Wang, Huixin; Lai, Wenqing; Zhang, Tianhong; Zhang, Zhenqing; Ye, Ling; Jiang, Shibo; Liu, Keliang

    2016-01-01

    Peptides derived from the N-terminal heptad repeat (NHR) of HIV-1 gp41 can be potent inhibitors against viral entry when presented in a nonaggregating trimeric coiled-coil conformation via the introduction of exogenous trimerization motifs and intermolecular disulfide bonds. We recently discovered that crosslinking isopeptide bridges within the de novo helical trimers added exceptional resistance to unfolding. Herein, we attempted to optimize (CCIZN17)3, a representative disulfide bond-stabilized chimeric NHR-trimer, by incorporating site-specific interhelical isopeptide bonds as the redox-sensitive disulfide surrogate. In this process, we systematically examined the effect of isopeptide bond position and molecular sizes of auxiliary trimeric coiled-coil motif and NHR fragments on the antiviral potency of these NHR-trimers. Pleasingly, (IZ14N24N)3 possessed promising inhibitory activity against HIV-1 infection and markedly increased proteolytic stability relative to its disulfide-tethered counterpart, suggesting good potential for further development as an effective antiviral agent for treatment of HIV-1 infection. PMID:27562370

  9. X-ray fluorescence analysis of yellow pigments in altarpieces by Valencian artists of the XV and XVI centuries

    NASA Astrophysics Data System (ADS)

    Ferrero, J. L.; Roldán, C.; Ardid, M.; Navarro, E.

    1999-02-01

    XRF analysis has allowed a quick and precise detection and identification of the inorganic elements that compose the yellow pigments in altarpieces of the XV and XVI centuries painted by the Valencian artists Miguel Alcañiz, Vicente Macip, Juan de Juanes, Hernando Yáñez de la Almedina and Hernando Llanos. The analyses have been carried out with an XRF portable system that consists of a tube of X-rays and detectors of Si(Li) and cadmium zinc telluride. This system has enabled a non-aggressive and non-destructive analysis of many pieces at the Museo de Bellas Artes of Valencia (Spain). Among the yellow pigments we have identified a pigment composed by lead and tin oxides named lead-tin yellow (Pb 2SnO 4), frequently used in European paintings from the XIV century until the first half of the XVIII century. This fact demonstrates the influence of elements and pictorial techniques from Europe to the region of Valencia.

  10. Manuscript "Collection of Solved Problems of General Astronomy" by Vojislav Miskovic

    NASA Astrophysics Data System (ADS)

    Pejovic, N.

    2009-09-01

    In this paper we present the first university problems book concerning astronomy written in Serbian. The topic is "Zbirka rešenih zadataka iz opšte astronomije" (A Collection of Solved Problems of General Astronomy) by Prof. Vojislav Mi\\vsković. The first part of this collection was published in 1956 in Belgrade. The second one is still in the form of a manuscript. Though completely prepared for publishing, it has never been published. From the methodical point of view the collection was interestingly and nicely arranged. All astronomical notions and formulae are treated in details and well explained so that no complementary textbook is needed. A special attention is devoted to the numerical solution of the problems, which is not only missing in Serbian schools, but also, as said by Mi\\vsković in the Preface, is not properly valued. This paper treats both parts of this Collection which have been digitized and are available in the Virtual Library of the National Digitization Centre (Virtual Library, http://elib.matf.bg.ac.yu:8080/virlib/). By means of the manuscript digitization the second part of the Collection has become available to public use.

  11. Evaluation of antibacterial, antifungal, and antioxidant activities of safflower natural dyes during flowering.

    PubMed

    Salem, Nidhal; Msaada, Kamel; Elkahoui, Salem; Mangano, Giuseppe; Azaeiz, Sana; Ben Slimen, Imen; Kefi, Sarra; Pintore, Giorgio; Limam, Ferid; Marzouk, Brahim

    2014-01-01

    Two Carthamus tinctorius varieties (Jawhara and 104) were studied in order to investigate their natural dyes contents and biological activities. Obtained results showed that quinochalcone contents and antioxidant activities varied considerably as function of flowering stages. So flowers at fructification stage contained the highest carthamin content with the strongest antioxidant capacity with all assays (FRAP, DPPH, and chelating power methods). In parallel, we showed a decrease in the content of precarthamin. The quantitative variation of these molecules could be due to colour change of C. tinctorius flowers. Correlation analysis indicated that the ABTS method showed the highest correlation coefficients with carthamin and precarthamin contents, that is, 0.886 and 0.973, respectively. Concerning the regional effect, the contents of precarthamin and carthamin varied significantly (P < 0.05) at studied regions with the optimum production given by samples of Beja (902.41 μg/g DW and 42.05 μg/g DW, respectively, at flowering stage). During flowering, the antimicrobial activity of these two natural dyes increased where the maximum inhibitory effect mentioned with carthamin mainly against E. coli (iz = 25.89 mm) at fructification stage. Therefore, the increased frequency of resistance to commonly used antibiotics leads to the search for new effective natural drugs at food and pharmaceutical industries. PMID:25045699

  12. Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection

    PubMed Central

    Wang, Chao; Li, Xue; Yu, Fei; Lu, Lu; Jiang, Xifeng; Xu, Xiaoyu; Wang, Huixin; Lai, Wenqing; Zhang, Tianhong; Zhang, Zhenqing; Ye, Ling; Jiang, Shibo; Liu, Keliang

    2016-01-01

    Peptides derived from the N-terminal heptad repeat (NHR) of HIV-1 gp41 can be potent inhibitors against viral entry when presented in a nonaggregating trimeric coiled-coil conformation via the introduction of exogenous trimerization motifs and intermolecular disulfide bonds. We recently discovered that crosslinking isopeptide bridges within the de novo helical trimers added exceptional resistance to unfolding. Herein, we attempted to optimize (CCIZN17)3, a representative disulfide bond-stabilized chimeric NHR-trimer, by incorporating site-specific interhelical isopeptide bonds as the redox-sensitive disulfide surrogate. In this process, we systematically examined the effect of isopeptide bond position and molecular sizes of auxiliary trimeric coiled-coil motif and NHR fragments on the antiviral potency of these NHR-trimers. Pleasingly, (IZ14N24N)3 possessed promising inhibitory activity against HIV-1 infection and markedly increased proteolytic stability relative to its disulfide-tethered counterpart, suggesting good potential for further development as an effective antiviral agent for treatment of HIV-1 infection. PMID:27562370

  13. Particulate matter (PM₁₀) induces metalloprotease activity and invasion in airway epithelial cells.

    PubMed

    Morales-Bárcenas, Rocío; Chirino, Yolanda I; Sánchez-Pérez, Yesennia; Osornio-Vargas, Álvaro Román; Melendez-Zajgla, Jorge; Rosas, Irma; García-Cuellar, Claudia María

    2015-09-17

    Airborne particulate matter with an aerodynamic diameter ≤ 10 μm (PM10) is a risk factor for the development of lung diseases and cancer. The aim of this work was to identify alterations in airway epithelial (A549) cells induced by PM10 that could explain how subtoxic exposure (10 μg/cm(2)) promotes a more aggressive in vitro phenotype. Our results showed that cells exposed to PM10 from an industrial zone (IZ) and an urban commercial zone (CZ) induced an increase in protease activity and invasiveness; however, the cell mechanism is different, as only PM10 from CZ up-regulated the activity of metalloproteases MMP-2 and MMP-9 and disrupted E-cadherin/β-catenin expression after 48 h of exposure. These in vitro findings are relevant in terms of the mechanism action of PM10 in lung epithelial cells, which could be helpful in understanding the pathogenesis of some human illness associated with highly polluted cities. PMID:26047787

  14. Nonmarket valuation of water quality in a rural transition economy in Turkey applying an a posteriori bid design

    NASA Astrophysics Data System (ADS)

    Bederli Tümay, Aylin; Brouwer, Roy

    2007-05-01

    In this paper, we investigate the economic benefits associated with public investments in wastewater treatment in one of the special protected areas along Turkey's touristic Mediterranean coast, the Köyceǧiz-Dalyan watershed. The benefits, measured in terms of boatable, fishable, swimmable and drinkable water quality, are estimated using a public survey format following the contingent valuation (CV) method. The study presented here is the first of its kind in Turkey. The study's main objective is to assess public perception, understanding, and valuation of improved wastewater treatment facilities in the two largest population centers in the watershed, facing the same water pollution problems as a result of lack of appropriate wastewater treatment. We test the validity and reliability of the application of the CV methodology to this specific environmental problem in a rural transition economy and evaluate the transferability of the results within the watershed. In order to facilitate willingness to pay (WTP) value elicitation we apply a novel dichotomous choice procedure where bid design takes place a posteriori instead of a priori. The statistical efficiency of different bid vectors is evaluated in terms of the estimated welfare measures' mean square errors using Monte Carlo simulation. The robustness of bid function specification is analyzed through average WTP and standard deviation estimated using parametric and nonparametric methods.

  15. Heavy-metal complexation by de novo peptide design.

    PubMed

    Farrer, Brian T; Pecoraro, Vincent L

    2002-11-01

    From poisoning caused by lead-based paint on domestic buildings to groundwater contamination by naturally occurring arsenic deposits in India, heavy-metal toxicity is a global health problem. Contaminated ground water and acute cases of heavy-metal poisoning are treated with chelators to remove the heavy metals from the contaminated site or person. This review discusses the effort to generate heavy-metal chelators through peptide de novo design. De novo design entails the design of a primary sequence that will precisely fold into a predetermined secondary and tertiary protein structure. The first-generation peptide chelator used to initiate this investigation is the three-stranded coild coil containing Cys. Cys provides a potential trigonal binding site with soft thiolate ligands, which has been proposed to provide specific interactions with heavy metals. This hypothesis derives from the observation that similar sites on natural proteins show selectivity for heavy metals over other essential metals, such as Zn or Mg. A description of two systems, the TRI series and the IZ-AC peptide, is given, highlighting the interaction of these peptides with Hg, Cd, As and Pb. Arguments are also presented for the potential use of three-helix bundles as a second-generation design. PMID:12478724

  16. Phytochemical study and screening for antimicrobial activity of flavonoids of Euphorbia hirta

    PubMed Central

    Singh, Geeta; Kumar, Padma

    2013-01-01

    Objective: This study aims to phytochemical and antimicrobial study of Euphorbia hirta Euphorbiaceae). Materials and Methods: Antimicrobial activity of flavonoids (free and bound) of Euphorbia hirta L. was determined by disc diffusion assay against four bacteria (Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, and Staphylococcus aureus) and four fungi (Aspergillus flavus, Aspergillus niger, Trichophyton mentagrophytes, and Candida albicans). Minimum inhibitory concentration (MIC) of the extract was evaluated through micro broth dilution method, while minimum bactericidal/fungicidal concentration was determined by subculturing the relevant samples. Total activity (TA) of extracts against each sensitive pathogen was also evaluated. Results: Out of fungi; A. flavus, A. niger, and T. mentagrophytes were found to be resistant, against which none of the tested extracts showed activity. Bound flavonoids extract of root showed best activity against C. albicans (inhibition zone (IZ) 27.66, MIC 0.039, minimum fungicidal concentration (MFC) 0.039). TA of free flavonoid extract of root was found to be the same for P. mirabilis and S. aureus (192.30 ml/g). Two flavonoids quercetin and kaempferol were identified in the bound flavonoids of stem extract which showed activity against all the microorganisms. Conclusion: Results of the present investigation indicate that E. hirta has good antimicrobial activity with low range of MIC, hence can be exploited for future plant-based antimicrobial drugs. PMID:24083146

  17. Balsscallichirus Sakai, 2011 (Decapoda: Axiidea: Callianassidae) in the fossil record: systematics and palaeobiogeography

    PubMed Central

    Hyžný, Matúš

    2016-01-01

    The fossil record of the ghost shrimp genus Balsscallichirus Sakai, 2011 (Crustacea: Decapoda: Callianassidae) is revised. Barnardcallichirus Sakai, 2011 and Tirmizicallichirus Sakai, 2011 are considered subjective synonyms of Balsscallichirus. Based on the examination of extant species it is argued that the morphology of the major cheliped merus, in combination with other hard part morphology characters, is sufficient for assignment of the fossil material into the genus. Main identifying characters are on merus which is keeled along its midline and its lower half is tuberculated; its lower margin possesses broad proximal meral hook continuing into a lobe distally; the entire lower margin is subdivided into numerous irregularly spaced spines. Three species, Callianassa sismondai A. Milne-Edwards, 1860, C. floriana Glaessner, 1928, and Podocallichirus laepaensis Hyžný & Muñiz, 2012, originally described from the Miocene of Italy, Austria and Spain, respectively, are assigned to Balsscallichirus herein. Neocallichirus wellsi Schweitzer, Feldmann & Gingerich, 2004 from the Upper Eocene of Pakistan is tentatively assigned to that genus as well. Spatial and temporal distribution of the genus indicates that at least since the Oligocene, and possibly even sooner (the Late Eocene), the genus has been restricted to the Western Tethys Region. Later, it migrated also into West Atlantic establishing present day communities. PMID:27499568

  18. Separating the spectra of binary stars I. A simple method: Secondary reconstruction

    NASA Astrophysics Data System (ADS)

    Ferluga, S.; Floreano, L.; Bravar, U.; Bedalo, C.

    1997-01-01

    We present a practical method for the analysis of spectroscopic binaries, reconstructing the lines of the two components of the system. We show that the problem of the separation of binary spectra can be solved in an easy way, under most common conditions. One pair of observations may be sufficient, if taken at different orbital phases of the system, preferably at opposite quadratures. The separation procedure is discussed analytically, and a technique is described, which allows to restore the secondary lines in few steps. An algorithm is also provided, which derives the radial velocity of the secondary star, by directly analysing a difference line-profile obtained from the two input spectra. The efficiency of the method is tested, by reconstructing artificial line-profiles and simulated binary spectra as well. Then the procedure is applied to the eclipsing binary IZ Per, revealing for the first time its faint secondary spectrum. Based on observations performed at the Observatoire de Haute Provence (OHP), and made available through the Trieste-Aurelie-Archive (TAA).

  19. Evaluating the impact of climate change on groundwater resources in a small Mediterranean watershed.

    PubMed

    Ertürk, Ali; Ekdal, Alpaslan; Gürel, Melike; Karakaya, Nusret; Guzel, Cigdem; Gönenç, Ethem

    2014-11-15

    Western Mediterranean Region of Turkey is subject to considerable impacts of climate change that may adversely affect the water resources. Decrease in annual precipitation and winter precipitation as well as increase in temperatures are observed since 1960s. In this study, the impact of climate change on groundwater resources in part of Köyceğiz-Dalyan Watershed was evaluated. Evaluation was done by quantifying the impacts of climate change on the water budget components. Hydrological modeling was conducted with SWAT model which was calibrated and validated successfully. Climate change and land use scenarios were used to calculate the present and future climate change impacts on water budgets. According to the simulation results, almost all water budget components have decreased. SWAT was able to allocate less irrigation water because of the decrease of overall water due to the climate change. This resulted in an increase of water stressed days and temperature stressed days whereas crop yields have decreased according to the simulation results. The results indicated that lack of water is expected to be a problem in the future. In this manner, investigations on switching to more efficient irrigation methods and to crops with less water consumption are recommended as adaptation measures to climate change impacts. PMID:25064798

  20. The near wall TIRFM measurement of nano-tracer's statistical intensity distribution (SID) and determining the base intensity I0

    NASA Astrophysics Data System (ADS)

    Zheng, Xu; LNM Team

    2015-11-01

    The total internal reflection fluorescence microscopy (TIRFM) is an evanescent-wave-based technique for measuring nanoparticle dynamics very close to wall. The intensity of the evanescent wave decays exponentially (i.e. I(z) =I0exp(z/zp)) , which can provide information of the tracer particle position not just parallel but also normal to wall. However, considering the z information is encoded in tracer intensity, it is critical to determine the base intensity I0. In this study, we will first establish a model to describe the statistical intensity distribution (SID) of the nano-tracers observed in the evanescent field inspired by the works of Huang et al. A different function of particle-wall interaction and a term of the influence of the objective focal plane thickness are introduced in the present SID method. Then, TIRFM experiments are performed to measure the histogram of SID. The experimental histogram of SID is then fitted by the theoretical curve to determine I0 which is the only one fit parameter. By near wall velocity measurement, we will show that the SID method has a very high precision in determining I0 and the vertical z position of every nanotracer. Further tests show that the PDF of nano-tracers can reveal more information about how nanoparticles interact with the charged solid wall. This provides a promising method to detect the physical properties near interface.

  1. Programming standards for effective S-3D game development

    NASA Astrophysics Data System (ADS)

    Schneider, Neil; Matveev, Alexander

    2008-02-01

    When a video game is in development, more often than not it is being rendered in three dimensions - complete with volumetric depth. It's the PC monitor that is taking this three-dimensional information, and artificially displaying it in a flat, two-dimensional format. Stereoscopic drivers take the three-dimensional information captured from DirectX and OpenGL calls and properly display it with a unique left and right sided view for each eye so a proper stereoscopic 3D image can be seen by the gamer. The two-dimensional limitation of how information is displayed on screen has encouraged programming short-cuts and work-arounds that stifle this stereoscopic 3D effect, and the purpose of this guide is to outline techniques to get the best of both worlds. While the programming requirements do not significantly add to the game development time, following these guidelines will greatly enhance your customer's stereoscopic 3D experience, increase your likelihood of earning Meant to be Seen certification, and give you instant cost-free access to the industry's most valued consumer base. While this outline is mostly based on NVIDIA's programming guide and iZ3D resources, it is designed to work with all stereoscopic 3D hardware solutions and is not proprietary in any way.

  2. Synthesis and biological evaluation of two new radiolabelled estrogens: [125I](E)-3-methoxy-17alpha-iodovinylestra-1,3,5(10),6-tetraen-17beta-ol and.

    PubMed

    Melo e Silva, M C; Patrćio, L; Gano, L; Sá e Melo, M L; Inohae, E; Mataka, S; Thiemann, T

    2001-02-01

    The synthesis of two novel radiolabelled estrogen derivatives, [125I](E)-3-methoxy-17alpha-iodovinylestra-1,3,5(10),6-tetraen-17beta-ol (E[125I]IVDE) and [125I](Z)-3-methoxy-17alpha-iodovinylestra-1,3,5(10),6-tetraen-17beta-ol (Z[125I]IVDE), was carried out aiming to study the influence of the introduction of a C6-C7 double bond on the biological properties of the estradiol molecule. 3-Methoxyestra-1,3,5(10),6-tetraen-17-one was synthesised starting from a suitably protected estrone and subsequently converted into the 17alpha-ethynyl derivative. The radioiodinated derivatives were stereoselectively formed by radioiododestannylation of the corresponding tributylstannyl precursors. The biodistribution of the novel [125I]iodovinylestradiol derivatives was evaluated in immature female mice. Biological data indicated that the Z-isomer, owing to its higher in vivo uptake by the target tissue, has the preferable configuration for further development of similar compounds for estrogen receptor detection. PMID:11200884

  3. The chromatin environment shapes DNA replication origin organization and defines origin classes

    PubMed Central

    Cayrou, Christelle; Ballester, Benoit; Peiffer, Isabelle; Fenouil, Romain; Coulombe, Philippe; Andrau, Jean-Christophe; van Helden, Jacques; Méchali, Marcel

    2015-01-01

    To unveil the still-elusive nature of metazoan replication origins, we identified them genome-wide and at unprecedented high-resolution in mouse ES cells. This allowed initiation sites (IS) and initiation zones (IZ) to be differentiated. We then characterized their genetic signatures and organization and integrated these data with 43 chromatin marks and factors. Our results reveal that replication origins can be grouped into three main classes with distinct organization, chromatin environment, and sequence motifs. Class 1 contains relatively isolated, low-efficiency origins that are poor in epigenetic marks and are enriched in an asymmetric AC repeat at the initiation site. Late origins are mainly found in this class. Class 2 origins are particularly rich in enhancer elements. Class 3 origins are the most efficient and are associated with open chromatin and polycomb protein-enriched regions. The presence of Origin G-rich Repeated elements (OGRE) potentially forming G-quadruplexes (G4) was confirmed at most origins. These coincide with nucleosome-depleted regions located upstream of the initiation sites, which are associated with a labile nucleosome containing H3K64ac. These data demonstrate that specific chromatin landscapes and combinations of specific signatures regulate origin localization. They explain the frequently observed links between DNA replication and transcription. They also emphasize the plasticity of metazoan replication origins and suggest that in multicellular eukaryotes, the combination of distinct genetic features and chromatin configurations act in synergy to define and adapt the origin profile. PMID:26560631

  4. Constraining the geomagnetic field intensity in Western Europe during the 17-19th centuries from French faience shards

    NASA Astrophysics Data System (ADS)

    Rosen, J.; Genevey, A.; Gallet, Y.

    2003-12-01

    We obtained new archeointensity results for France from the analysis of seven groups of potsherds precisely dated from the beginning of the 17th century to the 19th century. These earthenware shards were found during excavations in Nevers which was an important production center of faience in France during the 17-18th centuries. For our intensity determinations, we used a new variant of the Thellier and Thellier (1959) method. This procedure ("IZZI" method; Tauxe et al., 2003) involves the alternation of pair of heatings in field-zero field ("IZ" steps) and pair of heatings in zero field-in field ("ZI" steps), and was specially designed to detect biased intensity results due to multi-domain magnetic grains. The raw intensity values were corrected for TRM anisotropy and cooling rate effects. Our preliminary results do not show strong intensity variations during the 17-19th centuries. In particularly they do not exhibit a rapid intensity decrease during the 17th century as predicted in Western Europe from the global geomagnetic models of Jackson et al. (2000). To constrain their models during the 1590-1840 period, during which directional but no intensity geomagnetic measurements are available, these authors used a backward extrapolation made on the basis of the linear decay of the dipole moment observed since 1840. Our study challenges the validity of this extrapolation and contributes to our knowledge on the recent variation of the dipole moment of the geomagnetic field.

  5. Quantitative comparison of myocardial blood flow in normal and infarcted hearts by high resolution scintigraphy

    SciTech Connect

    Hung, C.Y.; Burow, R.D.; Scherlag, B.J.; Basmadjian, G.P.; Lazzara, R.

    1984-01-01

    The standard method for measuring myocardial blood flow (MBF) with radioactive microspheres requires processing of selected tissue samples and consequent loss of exact relation to myocardial morphology. Also, in myocardial infarction (MI) there are inaccuracies due to overlap of tissues from borders of normal and MI. A new method uses Tc-99m labeled microspheres (20..mu..) which were injected into the left atrium in 18 normal dogs and 12 dogs with MI (5 had 1 day and 7 had 4 day old MI). The excised hearts were rinsed and frozen before ''bread-loaf'' sections, 3 mm thick, were cut. Images were acquired on a gamma camera with a volume resolution of 12 mm/sup 3/. A computer program for determining MBF was checked against the conventional microsphere method. The volume resolution of the latter method was 100 mm/sup 3/. The correlation coefficient between the two methods was r=0.96. Average MBF for a given section of normal RV and LV was 95 +- 13 and 119 +- 15 ml/min/100 g of tissue, respectively. Average MBF was compared in normal LV and from ischemic epicardium (IsZ) of the central MI and endocardial infarcted zone (IZ). The authors' new method, accurately and with high resolution, delineates zones of differing MBF and confirms the increase of MBF in surviving myocardium with healing.

  6. Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with Retinitis Pigmentosa.

    PubMed

    Gale, Michael J; Feng, Shu; Titus, Hope E; Smith, Travis B; Pennesi, Mark E

    2016-01-01

    The purpose of this study was to correlate features on flood-illuminated adaptive optics (AO) images with color fundus, fundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT) images in patients with retinitis pigmentosa (RP). We imaged 39 subjects diagnosed with RP using the rtx1™ flood-illuminated AO camera from Imagine Eyes (Orsay, France). We observed a correlation between hyper-autofluoresence changes on FAF, disruption of the interdigitation zone (IZ) on SD-OCT and loss of reflective cone profiles on AO. Four main patterns of cone-reflectivity were seen on AO: presumed healthy cone mosaics, hypo-reflective blurred cone-like structures, higher frequency disorganized hyper-reflective spots, and lower frequency hypo-reflective spots. These regions were correlated to progressive phases of cone photoreceptor degeneration observed using SD-OCT and FAF. These results help provide interpretation of en face images obtained by flood-illuminated AO in subjects with RP. However, significant ambiguity remains as to what truly constitutes a cone, especially in areas of degeneration. With further refinements in technology, flood illuminated AO imaging has the potential to provide rapid, standardized, longitudinal and lower cost imaging in patients with retinal degeneration. PMID:26427424

  7. Historical aspects of Mexican psychiatry.

    PubMed

    Bayardo, Sergio Javier Villaseñor

    2016-04-01

    Mexican psychiatry initiated since pre-Hispanic times. Historically, treatments were a mixture of magic, science and religion. Ancient Nahuas had their own medical concepts with a holistic view of medicine, considering men and cosmos as a whole. The first psychiatric hospital appeared in 1566 and a more modern psychiatric asylum emerged until 1910. International exchanges of theoretical approaches started in the National University with the visit of Pierre Janet. There were other important figures that influenced Mexican psychiatry, such as Erich Fromm, Henri Ey, Jean Garrabé and Yves Thoret. Regarding Mexican psychiatrists, some of the most important contributors to Mexican psychiatry were José Luis Patiño Rojas, Manuel Guevara Oropeza and Ramón de la Fuente Muñiz. This article includes excerpts from "Clinical Psychiatry", a book by Patiño Rojas where he tries to understand and describe the inner world experienced by patients with schizophrenia; also, the thesis conducted by Guevara Oropeza ("Psychoanalisis"), which is a critical comparison between the theories of Janet and Freud. Finally, we include "The study of consciousness: current status" by Ramón de la Fuente, which leads us through the initial investigations concerning consciousness, its evolution, and the contributions made by psychology, philosophy and neurobiology. PMID:27117799

  8. VizieR Online Data Catalog: Motion Verified Red Stars (MoVeRS) (Theissen+, 2016)

    NASA Astrophysics Data System (ADS)

    Theissen, C. A.; West, A. A.; Dhital, S.

    2015-09-01

    We present a photometric catalog of 8,735,004 proper motion selected low-mass stars (KML-spectral types) within the Sloan Digital Sky Survey (SDSS) footprint, from the combined SDSS-DR10, Two-Micron All-Sky Survey (2MASS) Point Source Catalog (PSC), and Wide-field Infrared Survey Explorer (WISE) AllWISE catalog. Stars were selected using r-i, i-z, r-z, z-J, and z-W1 colors, and SDSS, WISE, and 2MASS astrometry was combined to compute proper motions. The resulting 3,518,150 stars were augmented with proper motions for 5,216,854 earlier type stars from the combined SDSS and United States Naval Observatory B1.0 catalog (USNO-B). We used SDSS+USNO-B proper motions to determine the best criteria for selecting a clean sample of stars. Only stars whose proper motions were greater than their 2-sigma uncertainty were included. Our Motion Verified Red Stars (MoVeRS) catalog is available through SDSS CasJobs and VizieR. (2 data files).

  9. Adult female of Strongyloides stercoralis in respiratory secretions

    PubMed Central

    Bava, Bava Amadeo Javier; Cecilia, Domínguez; Alcides, Troncoso

    2013-01-01

    Objective To communicate the presence of adult females, rabditoid larvae and eggs of Strongyloides stercoralis (S. stercoralis) in the respiratory secretions obtained by tracheal aspirate from a HIV-negative patient who was suffering from polymyositis, and treated with corticoids and amethopterin and assisted by pneumonia. Methods The respiratory secretions submitted to the Parasitology Laboratory of the Muñiz Hospital were made more concentrated by centrifugation (1 500 r/min for 15 seconds). Wet mount microscopy was performed with the pellet. Results It revealed adult females, rabditoid larvae and eggs of S. stercoralis. Further parasitological studies performed after the start of the treatment with ivermectin on fresh fecal samples, gastric lavages and tracheal aspirates showed scanty mobile filariform and rabditoid larvae of the same parasite. Conclusions The presence of adult female S. stercoralis which has never been observed before in the clinical samples submitted to our Laboratory for investigation can be considered as an indirect marker of the severe immunosupression of the patient. PMID:23620857

  10. Two Dimensional Intermodulation Distortion Scanning of Superconducting Filter Resonators

    NASA Astrophysics Data System (ADS)

    Bischak, Michael; Remillard, Stephen

    2015-03-01

    Nonlinear superconducting conductivity produces distortion that has usually been measured globally across the entire sample. In order to fully understand the origin of non linearity, local methods must be used to examine specific points in the sample. The nonlinear Ohm's law, V =IZ(I) includes the current dependence in the impedance. The method in this work raster scans a magnetic loop probe across a sample. In order to address limited resolution, we reduced the size of the magnetic loop probe. Using the electromagnetic field solver, sonnet, two dimensional current simulations of superconducting microwave filters composed of Tl2Ba2CaCu2O8 or of YBa2Cu3O7 reveal microwave current which is bunched up at the corners and sides of the sample. Two dimensional images of third order intermodulation distortion made with the magnetic probe at the same corners and edges reveal elevated distortion in the same places. Using the magnetic probe, third order intermodulation was seen to come from the same corners and edges where the current is bunched. This research was funded by the National Science Foundation under grant number DMR-1206149.

  11. Relationship between Food Intake and Sleep Pattern in Healthy Individuals

    PubMed Central

    Crispim, Cibele Aparecida; Zimberg, Ioná Zalcman; dos Reis, Bruno Gomes; Diniz, Rafael Marques; Tufik, Sérgio; de Mello, Marco Túlio

    2011-01-01

    Study Objectives: The purpose of this study was to analyze the relationship between food intake and sleep patterns in healthy individuals. Methods: Fifty-two healthy volunteers (27 women and 25 men) were recruited to participate in the study. Volunteers underwent sleep evaluation through nocturnal polysomnography and completed a 3-day food diary to evaluate food intake. Results: No differences in sleep patterns were observed in either gender, except in the percentage of stage 1 sleep, which was greater in men. Different correlations were observed between sleep and dietary variables according to gender. The correlation between dietary and sleep variables in men indicated a negative relationship between nocturnal fat intake and the sleep latency, including REM sleep. The percentage of nocturnal fat intake correlated with sleep efficiency, sleep latency, REM latency, stage 2 sleep, REM sleep, and wake after sleep onset (WASO) in women. The percentage of nocturnal caloric intake correlated with sleep latency and efficiency in women. Conclusions: We conclude that food intake during the nocturnal period is correlated with negative effects on the sleep quality of healthy individuals. Indeed, food intake near the sleeping period (dinner and late night snack) was negatively associated with sleep quality variables. More studies are necessary to elucidate the real effect of food intake on sleep. Citation: Crispim CA; Zimberg IZ; dos Reis BG; Diniz RM; Tufik S; de Mello MT. Relationship between food intake and sleep pattern in healthy individuals. J Clin Sleep Med 2011;7(6):659-664. PMID:22171206

  12. What is the significance of interictal water diffusion changes in frontal lobe epilepsies?

    PubMed

    Guye, M; Ranjeva, J P; Bartolomei, F; Confort-Gouny, S; McGonigal, A; Régis, J; Chauvel, P; Cozzone, P J

    2007-03-01

    The aim of this study was to better understand the significance of interictal changes in water molecule diffusivity defined by diffusion-weighted imaging (DWI) in frontal lobe epilepsy (FLE), as well as to test the accuracy of interictal DWI in the definition of the epileptogenic zone (EZ). DWI was carried out in 14 patients with refractory FLE (9 negative-MRI) as well as in 25 controls. Statistical mapping analysis (SPM2) of diffusivity maps was used to detect, for each subject, significant diffusivity alterations. We then studied the relationships between diffusion and depth recorded electrical abnormalities. Clinical correlates of the extent of diffusivity changes were also tested. We found areas of significantly increased diffusivity (SID) in 13 patients. Eight had SID in the EZ, 9 within the irritative zone (IZ) and 12 outside, mainly in connected areas. We found a correlation between the extent of SID and the duration of epilepsy (p corrected=0.026, R=0.621). In addition, SID was significantly less widespread in negative-MRI patients (p=0.028). However, we found no significant differences concerning either seizure frequency (p=0.302), seizure generalization (p=0.841), history of status (p=0.396), or surgical outcome (p=0.606). We suggest that SID in normal appearing areas is not a specific signature of epileptogenicity in FLE, and is more likely to reflect multifactorial and potentially evolving neuro-glial injuries. PMID:17239624

  13. [Dr Srećko Marac (1921-1985): a physician, sychiatrist/phychotherapist, and a poet].

    PubMed

    Radovancević, Ljubomir; Pavlović, Eduard

    2009-01-01

    Srećko Marac was born in Susak in 1921 and died in Zagreb in 1990. Having completed the Susak grammar school, he moved to Padua and later to Zagreb to study medicine. During WW2 he dropped the studies and joined the antifascist resistance known as the People's Liberation War. After the war, he completed medical studies in Zagreb. He worked as army physician in Bjelovar and in the Military Hospital in Zagreb. He specialised in psychiatry and practiced psychotherapy in the former Zagreb Mental Health Centre. In 1973, he published his first selection of poems wrought over a long time, with a simple title Pjesme (Poems). The aim of this article was to take a better look at this 1973 collection, see its structure and composition, its content, moods, and ways it communicates to the reader. The collection consists of five parts: Ad tyrannos, Iz partizana (from Resistance), Lutanja/ traZenja/snovi...(Roamings, Quests, Dreams...), Satire i kusanja humora (Satire and Attempts at Humour), and More/brda i domovina (Sea, Hills, and Homeland). Instead of a conclusion, this article proposes to save this wonderful and compassionate poetphysician from oblivion. PMID:20500012

  14. Analysis of the rotational spectrum of the ground and first torsional excited states of monodeuterated ethane, CH3CH2D

    NASA Astrophysics Data System (ADS)

    Daly, Adam M.; Drouin, Brian J.; Groner, Peter; Yu, Shanshan; Pearson, John C.

    2015-01-01

    The pure rotational spectrum of mono-deuterated ethane, CH3CH2D, has been measured up to 1600 GHz and spectroscopic constants have been fit to 984 transitions in the ground state and 422 transitions in the first torsional excited state (ν18). Analyses of the ground state data were performed with the programs SPFIT, ERHAM and XIAM and of the first torsional state with SPFIT and ERHAM to extract molecular and spectroscopic constants. A combined fit of both states using ERHAM was used to determine ρ = 0.4344026(68), which in the symmetric limit is the ratio Iα/Iz and a measure of the periodicity of the internal rotation energy with K and the energy differences between the A and E torsional substates, ΔE(E-A), of 74.167(18) and -3382.23(34) MHz for the ground and excited states, respectively. Using these energy differences and the overtone transitions Δv = 2 from Raman measurements in the literature, the coefficients V3 and V6 of the potential function of the internal rotation in CH3CH2D were determined as V3 = 1004.56(4) cm-1 and V6 = 7.09(12) cm-1. This analysis lays the ground work for the assignment of the IR spectrum of CH3CH2D between (680-880 cm-1) which will help quantify isotopic ratios by remote sensing missions.

  15. DEEP 21 cm H I OBSERVATIONS AT z {approx} 0.1: THE PRECURSOR TO THE ARECIBO ULTRA DEEP SURVEY

    SciTech Connect

    Freudling, Wolfram; Zwaan, Martin; Staveley-Smith, Lister; Meyer, Martin; Catinella, Barbara; Minchin, Robert; Calabretta, Mark; Momjian, Emmanuel; O'Neil, Karen

    2011-01-20

    The 'ALFA Ultra Deep Survey' (AUDS) is an ongoing 21 cm spectral survey with the Arecibo 305 m telescope. AUDS will be the most sensitive blind survey undertaken with Arecibo's 300 MHz Mock spectrometer. The survey searches for 21 cm H I line emission at redshifts between 0 and 0.16. The main goals of the survey are to investigate the H I content and probe the evolution of H I gas within that redshift region. In this paper, we report on a set of precursor observations with a total integration time of 53 hr. The survey detected a total of eighteen 21 cm emission lines at redshifts between 0.07 and 0.15 in a region centered around {alpha}{sub 2000} {approx} 0{sup h}, {delta} {approx} 15{sup 0}42'. The rate of detection is consistent with the one expected from the local H I mass function. The derived relative H I density at the median redshift of the survey is {rho}{sub H{sub I}}[z = 0.125] = (1.0 {+-} 0.3){rho}{sub 0}, where {rho}{sub 0} is the H I density at zero redshift.

  16. Identification and characterization of a novel aac(6')-Iag associated with the blaIMP-1-integron in a multidrug-resistant Pseudomonas aeruginosa.

    PubMed

    Kobayashi, Kanao; Hayashi, Ikue; Kouda, Syuntaro; Kato, Fuminori; Fujiwara, Tamaki; Kayama, Shizuo; Hirakawa, Hideki; Itaha, Hideyuki; Ohge, Hiroki; Gotoh, Naomasa; Usui, Tsuguru; Matsubara, Akio; Sugai, Motoyuki

    2013-01-01

    In a continuing study from Dec 2006 to Apr 2008, we characterized nine multi-drug resistant Pseudomonas aeruginosa strains isolated from four patients in a ward at the Hiroshima University Hospital, Japan. Pulsed-field gel electrophoresis of SpeI-digested genomic DNAs from the isolates suggested the clonal expansion of a single strain; however, only one strain, NK0009, was found to produce metallo-β-lactamase. PCR and subsequent sequencing analysis indicated NK0009 possessed a novel class 1 integron, designated as In124, that carries an array of four gene cassettes: a novel aminoglycoside (AG) resistance gene, aac(6')-Iag, blaIMP-1, a truncated form of blaIMP-1, and a truncated form of aac(6')-Iag. The aac(6')-Iag encoded a 167-amino-acid protein that shows 40% identity with AAC(6')-Iz. Recombinant AAC(6')-Iag protein showed aminoglycoside 6'-N-acetyltransferase activity using thin-layer chromatography (TLC) and MS spectrometric analysis. Escherichia coli carrying aac(6')-Iag showed resistance to amikacin, arbekacin, dibekacin, isepamicin, kanamycin, sisomicin, and tobramycin; but not to gentamicin. A conjugation experiment and subsequent Southern hybridization with the gene probes for blaIMP-1 and aac(6')-Ig strongly suggested In124 is on a conjugal plasmid. Transconjugants acquired resistance to gentamicin and were resistant to virtually all AGs, suggesting that the In124 conjugal plasmid also possesses a gene conferring resistance to gentamicin. PMID:23950962

  17. Connexin 43 controls the multipolar phase of neuronal migration to the cerebral cortex.

    PubMed

    Liu, Xiuxin; Sun, Lin; Torii, Masaaki; Rakic, Pasko

    2012-05-22

    The prospective pyramidal neurons, migrating from the proliferative ventricular zone to the overlaying cortical plate, assume multipolar morphology while passing through the transient subventricular zone. Here, we show that this morphogenetic transformation, from the bipolar to the mutipolar and then back to bipolar again, is associated with expression of connexin 43 (Cx43) and, that knockdown of Cx43 retards, whereas its overexpression enhances, this morphogenetic process. In addition, we have observed that knockdown of Cx43 reduces expression of p27, whereas overexpression of p27 rescues the effect of Cx43 knockdown in the multipolar neurons. Furthermore, functional gap junction/hemichannel domain, and the C-terminal domain of Cx43, independently enhance the expression of p27 and promote the morphological transformation and migration of the multipolar neurons in the SVZ/IZ. Collectively, these results indicate that Cx43 regulates the passage of migrating neurons through their multipolar stage via p27 signaling and that interference with this process, by either genetic and/or environmental factors, may cause cortical malformations. PMID:22566616

  18. High Jc YBCO coated conductors on non-magnetic metallic substrate using YSZ-based buffer layer architecture

    NASA Astrophysics Data System (ADS)

    Celentano, G.; Boffa, V.; Ciontea, L.; Fabbri, F.; Galluzzi, V.; Gambardella, U.; Mancini, A.; Petrisor, T.; Rogai, R.; Rufoloni, A.; Varesi, E.

    2002-08-01

    Biaxially aligned YBa 2Cu 3O 7- δ (YBCO) thick films were deposited by pulsed laser ablation technique on cube textured non-magnetic Ni 89V 11 (Ni-V) substrate, using CeO 2/YSZ/CeO 2/NiO buffer layer architecture. The first NiO seed layer was formed by epitaxial oxidation of the Ni-V substrate. Structural analyses show typical full width at half maximum values of φ- and ω-scans less than 10° and 8°, respectively. The highest value obtained for the critical current density at 77 K and zero magnetic field was 6×10 5 A cm -2, which is close to that obtained for YBCO films grown on CeO 2/NiO buffer layer architecture.

  19. Numerical Analysis for Structural Safety Evaluation of Butterfly Valves

    NASA Astrophysics Data System (ADS)

    Shin, Myung-Seob; Yoon, Joon-Yong; Park, Han-Yung

    2010-06-01

    Butterfly valves are widely used in current industry to control the fluid flow. They are used for both on-off and throttling applications involving large flows at relatively low operating pressure especially in large size pipelines. For the industrial application of butterfly valves, it must be ensured that the valve could be used safety under the fatigue life and the deformations produced by the pressure of the fluid. In this study, we carried out the structure analysis of the body and the valve disc of the butterfly valve and the numerical simulation was performed by using ANSYS v11.0. The reliability of valve is evaluated under the investigation of the deformation, the leak test and the durability of the valve.

  20. Circumstances for Pluto-Charon mutual events in 1987

    NASA Technical Reports Server (NTRS)

    Tholen, David J.; Buie, Marc W.; Swift, Catherine E.

    1987-01-01

    Circumstances are tabulated for 88 Pluto-Charon mutual events occurring during the 1987 opposition. Charon is predicted to be completely obscured either by Pluto or Pluto's shadow during each passage behind Pluto during this opposition, providing several opportunities to study Pluto uncontaminated by the light of Charon. The duration of these total events is predicted to be from 32 to 79 min. The mutual-event season is now expected to conclude during the 1990 opposition. Two new stars have been selected as comparison stars for events occurring prior to opposition in 1987. Standardization of the primary comparison stars used in 1985 and 1986 has yielded the following magnitudes: B = 12.6044 + or - 0.0015 and V = 11.7956 + or - 0.0017 (1985 Primary); B = 13.1238 + or 0.0008 and V = 12.3885 + or - 0.0014 (1986 Primary).

  1. AY Vulpeculae, observations and analysis of a binary with an undermassive secondary

    SciTech Connect

    Walker, R.L.; Chambliss, C.R. Kutztown Univ., PA )

    1991-02-01

    AY Vulpeculae is an Algol-type eclipsig binary with P = 2.4124 days, and V = 11.70 at maximum light. The primary eclipse is very deep (2.2 mag), which makes the system of special interest. Complete light curves in UBV were obtained in 1986 using the 1.0 m reflector at the USNO Flagstaff Station. A revised ephemeris is presented which shows that the period has increased slightly over the past few decades. The light curves were analyzed using both the WINK method and the SIMPLEX algorithm. AY Vulpeculae is a semidetached system with the secondary filling its Roche lobe. The values derived for r1, r2, and the mass ratio (q) are 0.24, 0.26, and 0.24, respectively. The primary component has the characteristics of a subgiant of spectral class F0, while the secondary is a K-type subgiant and is decidedly undermassive. 24 refs.

  2. Effects of hot-salt stress corrosion on titanium alloys.

    NASA Technical Reports Server (NTRS)

    Gray, H. R.

    1972-01-01

    Susceptibility of titanium alloys to hot-salt stress-corrosion cracking increased as follows: Ti-2Al-11Sn-5Zr-1Mo-0.2Si (679), Ti-6Al-2Sn-4Zr-2Mo (6242), Ti-6Al-4V (64), Ti-6Al-4V-3Co (643), Ti-8Al-1Mo-1V (811), and Ti-13V-11Cr-3Al (13-11-3). The Ti-5Al-6Sn-2Zr-1Mo-0.25Si (5621S) alloy was both the least and most susceptible, depending on heat treatment. Such rankings can be drastically altered by heat-to-heat variations and processing conditions. Residual compressive stresses reduce susceptibility to stress-corrosion. Detection of substantial concentrations of hydrogen in all corroded alloys confirmed the generality of a previously proposed hydrogen embrittlement mechanism.

  3. High intensity vacuum ultraviolet and extreme ultraviolet production by noncollinear mixing in laser vaporized media

    NASA Astrophysics Data System (ADS)

    Todt, Michael A.; Albert, Daniel R.; Davis, H. Floyd

    2016-06-01

    A method is described for generating intense pulsed vacuum ultraviolet (VUV) and extreme ultraviolet (XUV) laser radiation by resonance enhanced four-wave mixing of commercial pulsed nanosecond lasers in laser vaporized mercury under windowless conditions. By employing noncollinear mixing of the input beams, the need of dispersive elements such as gratings for separating the VUV/XUV from the residual UV and visible beams is eliminated. A number of schemes are described, facilitating access to the 9.9-14.6 eV range. A simple and convenient scheme for generating wavelengths of 125 nm, 112 nm, and 104 nm (10 eV, 11 eV, and 12 eV) using two dye lasers without the need for dye changes is described.

  4. Location of the 1979 April 6 gamma-ray burst

    NASA Astrophysics Data System (ADS)

    Laros, J. G.; Evans, W. D.; Fenimore, E. E.; Klebesadel, R. W.; Barat, C.; Hurley, K.; Niel, M.; Vedrenne, G.; Estulin, I. V.; Zenchenko, V. M.

    1981-04-01

    A gamma-ray burst was recorded on 1979 April 6 at 1140 UT by instruments on the Pioneer Venus Orbiter (PVO), Venera 11 (V11), Venera 12 (V12), Prognoz 7 (P7), and International Sun-Earth Explorer-3 (ISEE-3) spacecraft. The event consisted of a single spike of 0.2 s duration and had a spectral feature near 400 keV, thus resembling the 1979 March 5 event in two respects. However, important differences in rise time and spectral hardness make it impossible to conclude positively that the two events shared the same mechanism or had comparable energetics. Constraints placed by these findings on the energetics and types of objects that could be responsible for the April 6 and possibly the March 5 bursts are discussed.

  5. Location of the 1979 April 6 gamma-ray burst

    NASA Technical Reports Server (NTRS)

    Laros, J. G.; Evans, W. D.; Fenimore, E. E.; Klebesadel, R. W.; Barat, C.; Hurley, K.; Niel, M.; Vedrenne, G.; Estulin, I. V.; Zenchenko, V. M.

    1981-01-01

    A gamma-ray burst was recorded on 1979 April 6 at 1140 UT by instruments on the Pioneer Venus Orbiter (PVO), Venera 11 (V11), Venera 12 (V12), Prognoz 7 (P7), and International Sun-Earth Explorer-3 (ISEE-3) spacecraft. The event consisted of a single spike of 0.2 s duration and had a spectral feature near 400 keV, thus resembling the 1979 March 5 event in two respects. However, important differences in rise time and spectral hardness make it impossible to conclude positively that the two events shared the same mechanism or had comparable energetics. Constraints placed by these findings on the energetics and types of objects that could be responsible for the April 6 and possibly the March 5 bursts are discussed.

  6. Investigation of the role of 10Li resonances in the halo structure of 11Li through the 11Li (p , d)10Li transfer reaction

    NASA Astrophysics Data System (ADS)

    Sanetullaev, A.; Kanungo, R.; Tanaka, J.; Alcorta, M.; Andreoiu, C.; Bender, P.; Chen, A. A.; Christian, G.; Davids, B.; Fallis, J.; Fortin, J. P.; Galinski, N.; Gallant, A. T.; Garrett, P. E.; Hackman, G.; Hadinia, B.; Ishimoto, S.; Keefe, M.; Krücken, R.; Lighthall, J.; McNeice, E.; Miller, D.; Purcell, J.; Randhawa, J. S.; Roger, T.; Rojas, A.; Savajols, H.; Shotter, A.; Tanihata, I.; Thompson, I. J.; Unsworth, C.; Voss, P.; Wang, Z.

    2016-04-01

    The first measurement of the one-neutron transfer reaction 11Li(p,d)10Li performed using the IRIS facility at TRIUMF with a 5.7 A MeV11Li beam interacting with a solid H2 target is reported. The 10Li residue was populated strongly as a resonance peak with energy Er = 0.62 ± 0.04 MeV having a total width Γ = 0.33 ± 0.07 MeV. The angular distribution of this resonance is characterized by neutron occupying the 1p1/2 orbital. A DWBA analysis yields a spectroscopic factor of 0.67 ± 0.12 for p1/2 removal strength from the ground state of 11Li to the region of the peak.

  7. X-ray diffraction study of polycrystalline BiFeO3 thin films under electric field

    NASA Astrophysics Data System (ADS)

    Nakashima, Seiji; Sakata, Osami; Nakamura, Yoshitaka; Kanashima, Takeshi; Funakubo, Hiroshi; Okuyama, Masanori

    2008-07-01

    Diffraction measurements using 12.4keV x-ray of synchrotron radiation have been performed in (001)pc- and (110)pc-oriented polycrystalline 350-nm-thick BiFeO3 thin films on a Pt /TiO2/SiO2/Si substrate under electric field in air at RT. Unipolar rectangular pulse voltages having a 150ns width and a 804.09ns period have been applied to BiFeO3 with a Pt top electrode. A diffraction peak of the (001)pc [(110)pc] plane shifts from 14.602° (20.520°) to 14.588 (20.505°) due to piezoelectric response when a 12V (11V ) pulse is applied. Piezoelectric constants (d33) of (001)pc-oriented and (110)pc-oriented domains estimated from these peak shifts are 27.8 and 26.4pm/V, respectively.

  8. XO-2b: A Transiting Hot Jupiter in a Metal-rich Common Proper Motion Binary

    NASA Astrophysics Data System (ADS)

    Burke, Christopher J.; McCullough, P. R.; Valenti, J. A.; Summers, F. J.; Stys, J. E.; Johns-Krull, C. M.; Janes, K. A.; Heasley, J. N.; Bissinger, R.; Fleenor, M.; Foote, C. N.; Garcia-Melendo, E.; Gary, B. L.; Howell, P. J.; Mallia, F.; Masi, G.; Vanmunster, T.

    2007-05-01

    XO-2b, the second transiting extrasolar planet from the XO Project (McCullough et al. 2005), is approximately Jupiter-size and 0.6 Jupiter-mass with an orbital period of 2.6 days. The stellar host, XO-2, is a V=11.2, early K dwarf which is metal rich, [Fe/H]=+0.44. XO-2 has a high proper motion, 157 mas/yr, and has a common proper motion stellar companion with half arcmin separation. The two stars are nearly identical twins, with very similar spectra and apparent magnitudes. The global network of amateur and professional astronomers organized by the XO project confirmed the XO-2b transit light curve two days after being notified that it was a high-priority candidate, and radial velocities confirmed its planetary mass eight days after that.

  9. Beta titanium alloys and their role in the titanium industry

    NASA Astrophysics Data System (ADS)

    Bania, Paul J.

    1994-07-01

    The class of titanium alloys generically referred to as the beta alloys is arguably the most versatile in the titanium family. Since these alloys offer the highest strength-to-weight ratios and deepest hardenability of all titanium alloys, one might expect them to compete favorably for a variety of aerospace applications. To the contrary, however, except for one very successful application (Ti-13V-11Cr-3Al on the SR-71), the beta alloys have remained a very small segment of the industry. As a perspective on this situation, this article reviews some past and present applications of titanium alloys. It also descibes some unique new alloys and applications that promise to reverse historical trends.

  10. Low-cost ion implantation and annealing technology for solar cells

    NASA Technical Reports Server (NTRS)

    Kirkpatrick, A. H.; Minnucci, J. A.; Greenwald, A. C.

    1980-01-01

    Ion implantation and thermal annealing techniques for processing junctions and back surface layers in solar cells are discussed. Standard 10 keV (31)p(+) junction implants and 25 keV (11)B(+) back surface implants in combination with three-step furnace annealing are used for processing a range of silicon materials and device structures. Cells with efficiencies up to 16.5% AM1 are being produced, and large-area terrestrial cells with implanted junctions and back fields being fabricated in pilot production exhibit average efficiencies in excess of 15% AM1. Thermal annealing methods for removal of the radiation damage caused by implantation should be replaced by transient processing techniques in future production. Design studies have been completed for solar cell processing implanters to support 10 MW/yr and 100 MW/yr production lines, and analyses indicate that implantation costs can be reduced to approximately 1 cent/watt.

  11. High-resolution synchrotron infrared spectroscopy of acrolein: The vibrational levels between 850 and 1020 cm-1

    NASA Astrophysics Data System (ADS)

    McKellar, A. R. W.; Billinghurst, B. E.; Xu, Li-Hong; Lees, R. M.

    2015-11-01

    Using spectra obtained at the Canadian Light Source synchrotron radiation facility, a previously unobserved out-of-plane vibration of trans-acrolein (propenal) is reliably assigned for the first time. Its origin is at 1002.01 cm-1, which is about 20 cm-1 higher than usually quoted in the past. This mode is thus labelled as v14, leaving the label v15 for the known vibration at 992.66 cm-1. Weak combination bands 171182 ← 182, 171131 ← 131, 121182 ← 181, and 171182 ← 181 are studied for the first time, and assignments in the known v11, v16, and v15 fundamental bands are also extended. The seven excited vibrations involved in these bands are analyzed, together with five more unobserved vibrations in the same region (850-1020 cm-1), in a large 12-state simultaneous fit which accounts for most of the many observed perturbations in the spectra.

  12. Time-resolved spin-dependent processes in magnetic field effects in organic semiconductors

    NASA Astrophysics Data System (ADS)

    Peng, Qiming; Li, Xianjie; Li, Feng

    2012-12-01

    We investigated the time-resolved magnetic field effects (MFEs) in tri-(8-hydroxyquinoline)-aluminum (Alq3) based organic light-emitting diodes (OLEDs) through the transient electroluminescence (EL) method. The values of magneto-electroluminescence (MEL) decrease with the time, and the decreasing slope is proportional to the driving voltage. Specifically, negative MELs are seen when the driving voltage is high enough (V > 11 V). We propose a model to elucidate the spin-dependent processes and theoretically simulate the time-resolved MELs. In particular, this dynamic analysis of time-resolved MELs reveals that the intersystem crossing between singlet and triplet electron-hole pairs and the triplet-triplet annihilation are responsible for the time-resolved MELs at the beginning and enduring periods of the pulse, respectively.

  13. WASP-29b: A SATURN-SIZED TRANSITING EXOPLANET

    SciTech Connect

    Hellier, Coel; Anderson, D. R.; Maxted, P. F. L.; Smalley, B.; Collier Cameron, A.; Brown, D. J. A.; Enoch, B.; Gillon, M.; Lendl, M.; Queloz, D.; Triaud, A. H. M. J.; Pepe, F.; Segransan, D.; Udry, S.; West, R. G.; Lister, T. A.; Pollacco, D.

    2010-11-01

    We report the discovery of a Saturn-sized planet transiting a V = 11.3, K4 dwarf star every 3.9 days. WASP-29b has a mass of 0.24 {+-} 0.02 M {sub Jup} and a radius of 0.79 {+-} 0.05 R {sub Jup}, making it the smallest planet so far discovered by the WASP survey, and the exoplanet most similar in mass and radius to Saturn. The host star WASP-29 has an above-solar metallicity and fits a possible correlation for Saturn-mass planets such that planets with higher-metallicity host stars have higher core masses and thus smaller radii.

  14. Probing Planetary Formation and Evolution Through Occultations

    NASA Astrophysics Data System (ADS)

    Rodriguez, Joseph E.; KELT Team

    2016-01-01

    The circumstellar environments of young stellar objects (YSOs) involve complex dynamical interactions between dust and gas that directly influence the formation of planets. However, our understanding of the evolution from the material in the circumstellar disk to the thousands of planetary systems discovered to date, is limited. One means to better constrain the size, mass, and composition of this planet-forming material is to observe a YSO being eclipsed by its circumstellar disk. Through this dissertation project, we are discovering and characterizing both disk eclipsing systems and exoplanets using the Kilodegree Extremely Little Telescope (KELT) project. KELT is a photometric survey for transiting planets orbiting bright stars (8 < V < 11); such bright planet host targets are well-suited for atmospheric characterization of the planets. KELT has discovered 15 planets transiting stars brighter than V ~11 to date. I will present some of the recently discovered planets from the survey and discuss their potential to advance our understanding of planetary atmospheres. In addition, KELT provides photometric monitoring of ~3 million stars, presenting the opportunity to perform multi-year studies of stellar variability generally and rare disk occultations specifically. Using time-series photometry from KELT we are conducting the Disk Eclipse Search with KELT (DESK) survey to look for disk eclipsing events, specifically in young stellar associations. To date, the survey has discovered and analyzed four previously unknown large dimming events around the stars RW Aurigae, V409 Tau, AA Tau, and TYC 2505-672-1, the latter now representing the longest-period eclipsing object known (period ~ 69 years). I will describe our results for planet atmosphere characterization and for protoplanetary disk structure and composition, and discuss how to search for these kinds of systems in future surveys such as LSST.

  15. State of the Art in Beta Titanium Alloys for Airframe Applications

    NASA Astrophysics Data System (ADS)

    Cotton, James D.; Briggs, Robert D.; Boyer, Rodney R.; Tamirisakandala, Sesh; Russo, Patrick; Shchetnikov, Nikolay; Fanning, John C.

    2015-06-01

    Beta titanium alloys were recognized as a distinct materials class in the 1950s, and following the introduction of Ti-13V-11Cr-3Al in the early 1960s, intensive research occurred for decades thereafter. By the 1980s, dozens of compositions had been explored and sufficient work had been accomplished to warrant the first major conference in 1983. Metallurgists of the time recognized beta alloys as highly versatile and capable of remarkable property development at much lower component weights than steels, coupled with excellent corrosion resistance. Although alloys such as Ti-15V-3Al-3Sn-3Cr, Ti-10V-2Fe-3Al and Ti-3AI-8V-6Cr-4Mo-4Zr (Beta C) were commercialized into well-known airframe systems by the 1980s, Ti-13V-11Cr-3Al was largely discarded following extensive employment on the SR-71 Blackbird. The 1990s saw the implementation of specialty beta alloys such as Beta 21S and Alloy C, in large part for their chemical and oxidation resistance. It was also predicted that by the 1990s, cost would be the major limitation on expansion into new applications. This turned out to be true and is part of the reason for some stagnation in commercialization of new such compositions over the past two decades, despite a good understanding of the relationships among chemistry, processing, and performance and some very attractive offerings. Since then, only a single additional metastable beta alloy, Ti-5Al-5V-5Mo-3Cr-0.5Fe, has been commercialized in aerospace, although low volumes of other chemistries have found a place in the biomedical implant market. This article examines the evolution of this important class of materials and the current status in airframe applications. It speculates on challenges for expanding their use.

  16. Compositions and Structures of Vanadium Oxide Cluster Ions VmOn(±) (m = 2-20) Investigated by Ion Mobility Mass Spectrometry.

    PubMed

    Wu, Jenna W J; Moriyama, Ryoichi; Tahara, Hiroshi; Ohshimo, Keijiro; Misaizu, Fuminori

    2016-06-01

    Stable compositions and geometrical structures of vanadium oxide cluster ions, VmOn(±), were investigated by ion mobility mass spectrometry (IM-MS). The most stable compositions of vanadium oxide cluster cations were (V2O4)(V2O5)(m-2)/2(+) and (VO2)(V2O5)(m-1)/2(+), depending on the clusters with even and odd numbers of vanadium atoms. Compositions one-oxygen richer than the cations, such as (V2O5)m/2(-) and (VO3)(V2O5)(m-1)/2(-), were predominantly observed for cluster anions. Assignments of these stable cluster ion compositions, which were determined as a result of collision-induced dissociations in IM-MS, can partly be explained with consideration of spin density distribution. By comparing the experimental collision cross sections (CCSs) obtained from ion mobility measurement with CCSs of the theoretically calculated structures, we confirmed the patterned growth of geometrical structures partially discussed in previous theoretical and spectroscopic studies. We showed that even sized (V2O5)m/2(±) where m = 6-12 had right polygonal prism structures except for the anionic V12O30(-), and for the clusters of odd numbers of vanadium m, cations and anions can either have bridged or pyramid structures. Both of the odd sized structures proposed were derivatives from the even sized right polygonal prism structures. The exception, V12O30(-), which had a CCS almost equal to that of the neighboring smaller V11O28(-), should have a structure of higher density than the right hexagonal prism, in which it was proposed to be a captured pyramid structure, derived from V11O28(-). PMID:27172006

  17. Dynamic secondary ion mass spectrometry and X-ray photoelectron spectroscopy on artistic bronze and copper artificial patinas

    NASA Astrophysics Data System (ADS)

    Balta, I. Z.; Pederzoli, S.; Iacob, E.; Bersani, M.

    2009-04-01

    To prevent the natural processes of decay and to develop and improve the treatments of conservation and restoration of artistic bronzes meaning statues and sculptures, it is important understanding the patination processes and the knowledge of artificially corroded surfaces. Chemical and physical characterization of artificial patinas obtained on artistic bronzes and coppers by using the 19th century Western traditional patination techniques and recipes by means of SEM-EDS, light microscopy and ATR/FT-IR has been done in previous studies [I.Z. Balta, L. Robbiola, Characterization of artificial black patinas on artistic cast bronze and pure copper by using SEM-EDS and light microscopy, in: Proceedings of the 13th European Microscopy Congress, 22-27 August 2004, Antwerp, Belgium, EMC 2004 CD-Rom Conference Preprints; I.Z. Balta, L. Robbiola, Traditional artificial artistic bronze and copper patinas—an investigation by SEM-EDS and ATR/FT-IR, in: Proceedings of the 8th International Conference on Non Destructive Investigations and Microanalysis for the Diagnostics and Conservation of the Cultural and Environmental Heritage, 15-19 May 2005, Lecce, Italy, ART'05 CD-Rom Conference Preprints]. Differences in morphology (structure, thickness, porosity, adherence, compactity, uniformity, homogeneity) and also in composition, on both artistic cast bronze and pure copper patinas, were clearly evidenced. Further in-depth investigation is required to be carried out in order to better understand the patinas mechanisms of formation and the layers kinetics of growth. The elemental and chemical analysis, either on a surface monolayer or in a depth profile, by using the Secondary Ion Mass Spectrometry (SIMS) and X-ray Photoelectron Spectroscopy (XPS) techniques, can provide this kind of information, unique at trace-level sensitivity. SIMS has proved to be a suitable analytical technique for analyzing small amounts of material with high atomic sensitivity (ppm or even ppb) and high

  18. Extragalactic circuits, transmission lines, and CR particle acceleration

    NASA Astrophysics Data System (ADS)

    Kronberg, Philipp P.; Lovelace, Richard V. E.

    2015-08-01

    A non-negligible fraction of a Supermassive Black Hole's (SMBH) rest mass energy gets transported into extragalactic space by a remarkable process in jets which are incompletely understood. What are the physical processes which transport this energy? It is likely that the energy flows electromagnetically, rather than via a particle beam flux. The deduced electromagnetic fields may produce particles of energy as high as ˜ 1020 eV. The energetics of SMBH accretion disk models and the electromagnetic energy transfer imply that a SMBH should generate a 1018 - 1019 Ampères current close to the black hole and its accretion disk. We describe the so far best observation-based estimate of the magnitude of the current flow along the axis of the jet extending from the nucleus of the active galaxy in 3C303. The current is measured to be I ˜ 1018 Ampères at ˜ 40 kpc away from the AGN. This indicates that organised current flow remains intact over multi-kpc distances. The electric current I transports electromagnetic power into free space, P = I2Z, where Z ˜ 30 Ohms is related to the impedance of free space, and this points to the existence of cosmic electric circuit. The associated electric potential drop, V = IZ, is of the order of that required to generate Ultra High Energy Cosmic Rays (UHECR). We also explore further implications, including disruption/deflection of the power flow and also why such measurements, exemplified by those on 3C303, are currently very difficult to make and to unambiguously interpret. This naturally leads to the topic of how such measurements can be extended and improved in the future. We describe the analogy of electromagnetically dominated jets with transmission lines. High powered jets in vacuo can be understood by approximate analogy with a waveguide. The importance of inductance, impedance, and other laboratory electrical concepts are discussed in this context.

  19. DES J0454–4448: Discovery of the first luminous z ≥ 6 quasar from the Dark Energy Survey

    DOE PAGESBeta

    Reed, S. L.

    2015-10-28

    We present the first results of a survey for high-redshift, z ≥ 6, quasars using izY multicolour photometric observations from the Dark Energy Survey (DES). Here we report the discovery and spectroscopic confirmation of the zAB, YAB = 20.2, 20.2 (M1450 = –26.5) quasar DES J0454–4448 with a redshift of z = 6.09±0.02 based on the onset of the Ly α forest and an H i near zone size of 4.1+1.1–1.2 proper Mpc. The quasar was selected as an i-band drop out with i–z = 2.46 and zAB < 21.5 from an area of ~300 deg2. It is the brightestmore » of our 43 candidates and was identified for spectroscopic follow-up solely based on the DES i–z and z–Y colours. The quasar is detected by WISE and has W1AB = 19.68. The discovery of one spectroscopically confirmed quasar with 5.7 < z < 6.5 and zAB ≤ 20.2 is consistent with recent determinations of the luminosity function at z ~ 6. DES when completed will have imaged ~5000 deg2 to YAB = 23.0 (5σ point source) and we expect to discover 50–100 new quasars with z > 6 including 3–10 with z > 7 dramatically increasing the numbers of quasars currently known that are suitable for detailed studies.« less

  20. RefMoB, a Reflectivity Feature Model-Based Automated Method for Measuring Four Outer Retinal Hyperreflective Bands in Optical Coherence Tomography

    PubMed Central

    Ross, Douglas H.; Clark, Mark E.; Godara, Pooja; Huisingh, Carrie; McGwin, Gerald; Owsley, Cynthia; Litts, Katie M.; Spaide, Richard F.; Sloan, Kenneth R.; Curcio, Christine A.

    2015-01-01

    Purpose. To validate a model-driven method (RefMoB) of automatically describing the four outer retinal hyperreflective bands revealed by spectral-domain optical coherence tomography (SDOCT), for comparison with histology of normal macula; to report thickness and position of bands, particularly band 2 (ellipsoid zone [EZ], commonly called IS/OS). Methods. Foveal and superior perifoveal scans of seven SDOCT volumes of five individuals aged 28 to 69 years with healthy maculas were used (seven eyes for validation, five eyes for measurement). RefMoB determines band thickness and position by a multistage procedure that models reflectivities as a summation of Gaussians. Band thickness and positions were compared with those obtained by manual evaluators for the same scans, and compared with an independent published histological dataset. Results. Agreement among manual evaluators was moderate. Relative to manual evaluation, RefMoB reported reduced thickness and vertical shifts in band positions in a band-specific manner for both simulated and empirical data. In foveal and perifoveal scans, band 1 was thick relative to the anatomical external limiting membrane, band 2 aligned with the outer one-third of the anatomical IS ellipsoid, and band 3 (IZ, interdigitation of retinal pigment epithelium and photoreceptors) was cleanly delineated. Conclusions. RefMoB is suitable for automatic description of the location and thickness of the four outer retinal hyperreflective bands. Initial results suggest that band 2 aligns with the outer ellipsoid, thus supporting its recent designation as EZ. Automated and objective delineation of band 3 will help investigations of structural biomarkers of dark-adaptation changes in aging. PMID:26132776

  1. DES J0454–4448: Discovery of the first luminous z ≥ 6 quasar from the Dark Energy Survey

    SciTech Connect

    Reed, S. L.

    2015-10-28

    We present the first results of a survey for high-redshift, z ≥ 6, quasars using izY multicolour photometric observations from the Dark Energy Survey (DES). Here we report the discovery and spectroscopic confirmation of the zAB, YAB = 20.2, 20.2 (M1450 = –26.5) quasar DES J0454–4448 with a redshift of z = 6.09±0.02 based on the onset of the Ly α forest and an H i near zone size of 4.1+1.1–1.2 proper Mpc. The quasar was selected as an i-band drop out with i–z = 2.46 and zAB < 21.5 from an area of ~300 deg2. It is the brightest of our 43 candidates and was identified for spectroscopic follow-up solely based on the DES i–z and z–Y colours. The quasar is detected by WISE and has W1AB = 19.68. The discovery of one spectroscopically confirmed quasar with 5.7 < z < 6.5 and zAB ≤ 20.2 is consistent with recent determinations of the luminosity function at z ~ 6. DES when completed will have imaged ~5000 deg2 to YAB = 23.0 (5σ point source) and we expect to discover 50–100 new quasars with z > 6 including 3–10 with z > 7 dramatically increasing the numbers of quasars currently known that are suitable for detailed studies.

  2. Extraction, gas chromatography–mass spectrometry analysis and screening of fruits of Terminalia chebula Retz. for its antimicrobial potential

    PubMed Central

    Singh, Geeta; Kumar, Padma

    2013-01-01

    Background: Terminalia chebula is called the “king of medicines” in Tibet and is always listed first in the Ayurvedic meteria medica because of its extraordinary powers of healing. Objective: Identification, isolation and screening of pyrogallol which are responsible for antimicrobial property of fruits of Terminalia chebula. Materials and Methods: Ethyl acetate fraction of fruits of Terminalia chebula was subjected to Gas chromatography–mass spectrometry (GC-MS) for the components present in the extract. Results: Sixty four constituents were identified out of which kaempferol-3-O-rutinoside flavonoid and Vitamin E has been detected for the first time in fruits of this plant. Pyrogallol (46.26%) which was the major component of the extract in GC-MS analysis was isolated and screened for antimicrobial activity against selected test pathogens by Disc Diffusion Assay. Crude ethyl acetate fraction of the fruits was showing the same activity potential as was observed for pure pyrogallol which was the major component as per GC-MS analysis. The most sensitive species among the bacteria was Enterobacter aerogenes with highest inhibition zone (IZ = 31 mm; AI = 1.409 ± 0.046) even at minimum inhibitory concentration (0.039 mg/ml). Conclusion: Hence activity shown by crude ethyl acetate fraction might be due to pyrogallol present in the extract. On the basis of results it can be advocate that achieved crude ethyl acetate fraction can be explored for preparing antimicrobial drugs in future for the infectious caused by the pathogens tested in the study. PMID:23901211

  3. Neutral Hydrogen in Galaxies at the Present Epoch

    NASA Astrophysics Data System (ADS)

    Rao, Sandhya; Briggs, Frank

    1993-12-01

    The evolution of the neutral hydrogen content of galaxies as a function of time is an important constraint on processes in galactic evolution. We present a comprehensive, statistical description of the H I content and distribution within galaxies at the present epoch and compare these statistics with the properties of H I associated with "damped Lyα" absorption systems at high redshift that are observed in the spectra of QSOs. ΩH I(z = 0), the H I mass density at the present epoch relative to the present critical mass density, is found to be (2.5±0.6) × 10-4h-175, consistent with the decreasing trend of the H I content with time deduced from QSO absorption line statistics for redshifts from about 4 to 0.5 (Lanzetta 1993). Spiral galaxies contain an overwhelming 89% of this neutral hydrogen mass. The rest is contained in irregulars, SOs, and ellipticals Spirals also offer the largest cross section to line-of-sight absorption of light from QSOs By considering nearby spirals as potential absorbers, the interception probability as a function of the H I column density, N(H I), is derived for comparison with the cross sections inferred from observations of damped Lyman-alpha systems. The comparison shows that the damped Lyα lines are created by absorbers that subtend larger cross sections than present-day spirals by a factor of 5 implying that galaxies were either larger or more numerous at z ˜ 2.5.

  4. Optical broad-band photometry and reference image for APMUKS(BJ) B215839.70-615403.9 / ASASSN-15lh from the Dark Energy Survey

    NASA Astrophysics Data System (ADS)

    Melchior, Peter; Drlica-Wagner, Alexander; Bechtol, Keith; Rykoff, Eli; Hartley, William; Dark Energy Survey Collaboration

    2015-07-01

    We report optical broad-band photometry of the host galaxy APMUKS(BJ) B215839.70-615403.9 of SLSN ASASSN-15lh (ATel #7642; Dong et al., arXiv:1507.03010). The images were obtained using the DECam imager on the Blanco 4-m telescope at NOAO's Cerro Tololo Inter-American Observatory during Year-2 observations of the Dark Energy Survey (DES). A preliminary reduction of the images was performed by the DES Data Management pipeline (Mohr et al. 2012, SPIE Conference Series, 84510D; Desai et al. 2012, ApJ, 757, 83). The photometry was measured using SExtractor with additional calibration via stellar locus regression to provide magnitude zero points with 2-3% calibration uncertainty for point sources (relative to 2MASS) and mildly increased uncertainties for extended sources. We fit the DES g-r, r-i, and i-z colors to a red-sequence model from redMaPPer (Rykoff et al. 2014, ApJ, 785, 104) and obtain a redshift 0.25±0.02, consistent with the spectroscopic redshift of z = 0.2326 (ATel #7774). Fixed to that redshift, the host photometry is fully consistent with a red-sequence galaxy. We combine photometry from DES grizY with VHS NIR (ATel #7776) and WISE IR and fit a linear combination of single stellar populations with a variety of ages. We find that the fit is dominated by an old (5 Gyr) component, consistent with those of elliptical galaxies. We further compare with dusty SEDs taken from the latest set of templates in EAZY (Brammer, van Dokkum & Coppi, 2008, ApJ, 686, 1503). The combined host photometry is not well described by any of the dusty templates.

  5. [Adverse drug reactions in multidrug-resistant tuberculosis].

    PubMed

    Palmero, Domingo; Cruz, Víctor; Museli, Tomás; Pavlovsky, Hernán; Fernández, Juan; Waisman, Jaime

    2010-01-01

    Multidrug-resistant tuberculosis (MDRTB) poses difficulties in diagnosis and treatment, including increased frequency of adverse reactions to antituberculosis drugs (ADRAs), which compromise the effectiveness of treatment. This is specially complicated in the treatment of patients co-infected with HIV which includes the antiretroviral therapy plus the treatment of eventual comorbidities. A total of 121 MDRTB patients, 87 HIV-negative and 34 HIV positive, assisted in the Hospital F. J. Muñiz, Buenos Aires, during the period 2003-2007 were retrospectively studied. The incidence of ADRAs among the two groups of patients was compared. All the patients with adherence to treatment (no more than one abandon, recovered) were included in the study. Antituberculosis drugs used were: ethambutol, pyrazinamide, ofloxacin, moxifloxacin, cycloserine, ethionamide, PAS, streptomycin, kanamycin, amikacin and linezolid. The emergence of ADRAs and the proportion of severe reactions attributed to antituberculosis drugs were similar in both groups: 44.8% in HIV negative and 44.1% in HIV positive, but it was observed an additional 23.5% of adverse reactions to antiretroviral therapy in the second group. There were differences in the type of reactions and time of occurrence between the two groups. One HIV positive patient died of epidermolysis. The proportion of adverse reactions in HIV/AIDS patients increased 50% when those attributed to antiretroviral treatment were included. We conclude that the studied population showed a frequency of ADRAs higher than it would be expected in the treatment of susceptible TB, but there was no difference in its frequency among HIV-negative and positive patients. PMID:20920959

  6. Chromospheric activity properties and search for subdwarfs and extreme subdwarfs based on LAMOST stellar spectral survey

    NASA Astrophysics Data System (ADS)

    Zhang, Liyun; Pi, Qingfeng; Han, Xianming L.; Shi, Jianrong; Wang, Daimei; Luo, Ali; Zhang, Yong; Hou, Yonghui; Wang, Yuefei

    2016-04-01

    Big data obtained from a stellar spectroscopic survey carried out using the Large Sky Area Multi-object Fiber Spectroscopic Telescope (LAMOST, also known as Guo Shou Jing telescope) provide important information for studying chromospheric activity, variability of chromospheric activity, and chromospheric statistical properties, and for searching subdwarfs and extreme subdwarfs. Using as chromospheric activity indicator the Hα line, we detected 6391 active M stars among the 99741 stars in the M-star catalogue of the LAMOST survey. We also obtained the relationship between the fraction of active stars and the spectral types, which is consistent to previous results. We also studied the effects of activity on broadband photometric colors, and we did not see significant differences between active and inactive M stars. Using as spectroscopic molecular indicators the CaH123 and TiO5 lines, we found 1288 subdwarfs (including 120 active subdwarfs). We also found 15 extreme subdwarf (2 active extreme subdwarf) candidates. Our subdwarf candidates are slightly redder by about 0.05 mag in g-r compared with dwarfs using the g-r and r-i, and g-r and i-z color diagrams. Using our active M-star catalogue, we found that 898 stars exhibited Hα emission in at least two exposures (170 of them in at least three exposures). Among these 170 stars, 163 of them show variability in Hα emission on long timescales (more than 2.5 h). Furthermore, 34 stars show variability over short timescales (less than 2.5 h), and 29 actives show variability over both short and long time scales.

  7. Safety Culture Assessment in Petrochemical Industry: A Comparative Study of Two Algerian Plants

    PubMed Central

    Boughaba, Assia; Hassane, Chabane; Roukia, Ouddai

    2014-01-01

    Background To elucidate the relationship between safety culture maturity and safety performance of a particular company. Methods To identify the factors that contribute to a safety culture, a survey questionnaire was created based mainly on the studies of Fernández-Muñiz et al. The survey was randomly distributed to 1000 employees of two oil companies and realized a rate of valid answer of 51%. Minitab 16 software was used and diverse tests, including the descriptive statistical analysis, factor analysis, reliability analysis, mean analysis, and correlation, were used for the analysis of data. Ten factors were extracted using the analysis of factor to represent safety culture and safety performance. Results The results of this study showed that the managers' commitment, training, incentives, communication, and employee involvement are the priority domains on which it is necessary to stress the effort of improvement, where they had all the descriptive average values lower than 3.0 at the level of Company B. Furthermore, the results also showed that the safety culture influences the safety performance of the company. Therefore, Company A with a good safety culture (the descriptive average values more than 4.0), is more successful than Company B in terms of accident rates. Conclusion The comparison between the two petrochemical plants of the group Sonatrach confirms these results in which Company A, the managers of which are English and Norwegian, distinguishes itself by the maturity of their safety culture has significantly higher evaluations than the company B, who is constituted of Algerian staff, in terms of safety management practices and safety performance. PMID:25180135

  8. Neutral hydrogen in galaxy clusters: impact of AGN feedback and implications for intensity mapping

    NASA Astrophysics Data System (ADS)

    Villaescusa-Navarro, Francisco; Planelles, Susana; Borgani, Stefano; Viel, Matteo; Rasia, Elena; Murante, Giuseppe; Dolag, Klaus; Steinborn, Lisa K.; Biffi, Veronica; Beck, Alexander M.; Ragone-Figueroa, Cinthia

    2016-03-01

    By means of zoom-in hydrodynamic simulations, we quantify the amount of neutral hydrogen (H I) hosted by groups and clusters of galaxies. Our simulations, which are based on an improved formulation of smoothed particle hydrodynamics, include radiative cooling, star formation, metal enrichment and supernova feedback, and can be split into two different groups, depending on whether feedback from active galactic nuclei (AGN) is turned on or off. Simulations are analysed to account for H I self-shielding and the presence of molecular hydrogen. We find that the mass in neutral hydrogen of dark matter haloes monotonically increases with the halo mass and can be well described by a power law of the form M_{H I}(M,z)∝ M^{3/4}. Our results point out that AGN feedback reduces both the total halo mass and its H I mass, although it is more efficient in removing H I. We conclude that AGN feedback reduces the neutral hydrogen mass of a given halo by ˜50 per cent, with a weak dependence on halo mass and redshift. The spatial distribution of neutral hydrogen within haloes is also affected by AGN feedback, whose effect is to decrease the fraction of H I that resides in the halo inner regions. By extrapolating our results to haloes not resolved in our simulations, we derive astrophysical implications from the measurements of Ω _{H I}(z): haloes with circular velocities larger than ˜25 km s-1 are needed to host H I in order to reproduce observations. We find that only the model with AGN feedback is capable of reproducing the value of Ω _{H I}b_{H I} derived from available 21 cm intensity mapping observations.

  9. Semi-blind Eigen Analyses of Recombination Histories Using Cosmic Microwave Background Data

    NASA Astrophysics Data System (ADS)

    Farhang, M.; Bond, J. R.; Chluba, J.

    2012-06-01

    Cosmological parameter measurements from cosmic microwave background (CMB) experiments, such as Planck, ACTPol, SPTPol, and other high-resolution follow-ons, fundamentally rely on the accuracy of the assumed recombination model or one with well-prescribed uncertainties. Deviations from the standard recombination history might suggest new particle physics or modified atomic physics. Here we treat possible perturbative fluctuations in the free electron fraction, X e(z), by a semi-blind expansion in densely packed modes in redshift. From these we construct parameter eigenmodes, which we rank order so that the lowest modes provide the most power to probe X e(z) with CMB measurements. Since the eigenmodes are effectively weighed by the fiducial X e history, they are localized around the differential visibility peak, allowing for an excellent probe of hydrogen recombination but a weaker probe of the higher redshift helium recombination and the lower redshift highly neutral freezeout tail. We use an information-based criterion to truncate the mode hierarchy and show that with even a few modes the method goes a long way from the fiducial recombination model computed with RECFAST, X e, i(z), toward the precise underlying history given by the new and improved recombination calculations of COSMOREC or HYREC, X e, f(z), in the hydrogen recombination regime, though not well in the helium regime. Without such a correction, the derived cosmic parameters are biased. We discuss an iterative approach for updating the eigenmodes to further hone in on X e, f(z) if large deviations are indeed found. We also introduce control parameters that downweight the attention on the visibility peak structure, e.g., focusing the eigenmode probes more strongly on the X e(z) freezeout tail, as would be appropriate when looking for the X e signature of annihilating or decaying elementary particles.

  10. Distribution of infective gastrointestinal helminth larvae in tropical erect grass under different feeding systems for lambs.

    PubMed

    Tontini, Jalise Fabíola; Poli, Cesar Henrique Espírito Candal; Bremm, Carolina; de Castro, Juliane Machado; Fajardo, Neuza Maria; Sarout, Bruna Nunes Marsiglio; Castilhos, Zélia Maria de Souza

    2015-08-01

    This study examined tropical pasture contamination dynamics under different feeding systems for finishing lambs. The experiment aimed to evaluate the vertical distribution of gastrointestinal helminth infective larvae (L3) in erect grass subjected to grazing and to assess the parasite load and its impact on lamb performance in three production systems. Three treatments based on Aruana grass (Panicum maximum cv. IZ-5) were as follows: T1, grass only; T2, grass with 1.5% of body weight (BW) nutrient concentrate supplementation; and T3, grass with 2.5% BW concentrate supplementation. The randomized block design had three replicates of three treatments, with six lambs per replicate. L3 were recovered from three pasture strata (upper, middle, and bottom), each representing one third of the sward height, and correlated with microclimatic data. Significant differences (P < 0.05) were observed among treatments in the L3 recovery. Despite different grass heights between treatments and microclimates within the sward, the L3 concentration generally did not differ significantly among the three strata within a treatment (P > 0.05). Pasture microclimate did not correlate with larval recovery. At the end of the experiment, the animal fecal egg count was similar among treatments (P > 0.05). The results indicated that different lamb feeding systems in a tropical erect grassland caused differences in grass height but did not affect the distribution of infective larvae among strata. Larvae were found from the base to the top of the grass sward. PMID:26003429

  11. Defining the Flora Family: Reflectance Properties and Age

    NASA Astrophysics Data System (ADS)

    Dykhuis, Melissa J.; Molnar, Lawrence A.; Van Kooten, Samuel J; Greenberg, Richard

    2014-05-01

    The Flora family resides in the densely populated inner main belt, bounded in semimajor axis by the ν6 secular resonance and the Jupiter 3:1 mean motion resonance. The presence of several large families that overlap dynamically with the Floras (e.g. the Vesta, Baptistina, and Nysa-Polana families), and the removal of a significant fraction of Floras via the nearby ν6 resonance have historically complicated the Flora family's distinction in both proper orbital elements and reflectance properties. Here we use orbital information from AstDyS, color information from SDSS, and albedo information from WISE, to obtain the characteristic orbital and reflectance properties of the Floras, by sampling the core of the family in multidimensional phase space. We find the characteristic Flora SDSS colors to be a* = 0.127 ± 0.012 and i-z = -0.038 ± 0.008; the characteristic Flora albedo is pV = 0.295 ± 0.006. These properties allow us to select a high-purity sample of Floras with similar orbital and reflectance properties as required for a detailed dynamical study. We then use the young Karin family, for which we have an age determined via direct backward integration of members' orbits, to calibrate the Yarkovsky drift rates for the Flora family without having to estimate the Floras' material properties. The size-dependent dispersion of the Flora members in semimajor axis (the "V" plot) then yields an age for the family of 940+160-120 My. We discuss the effects on our age estimate of two independent processes that both introduce obliquity variations among the family members on short (My) timescales: 1) the capture of Flora members in spin-orbit resonance, and 2) YORP-driven obliquity variation through YORP cycles. Accounting for these effects does not significantly change the age determination.

  12. A new free-floating planet in the Upper Scorpius association

    NASA Astrophysics Data System (ADS)

    Peña Ramírez, K.; Béjar, V. J. S.; Zapatero Osorio, M. R.

    2016-02-01

    We report on a deep photometric survey covering an area of 1.17 deg2 in the young Upper Scorpius stellar association using VIMOS Iz and UKIDSS ZJHK data that was taken with several years in between. The search for the least massive population of Upper Scorpius (~5-10 Myr, 145 pc) is performed on the basis of various optical and infrared color-color and color-magnitude diagrams, including WISE photometry, in the magnitude interval J = 14.5-19 mag (completeness), which corresponds to substellar masses from 0.028 through 0.004 M⊙ at the age and distance of Upper Scorpius. We also present the proper motion analysis of the photometric candidates, finding that two objects successfully pass all photometric and astrometric criteria for membership in the young stellar association. One of them, USco J155150.2-213457, is a new discovery. We obtained low resolution, near-infrared spectroscopy (R ~ 450, 0.85-2.35 μm) of this new finding using the FIRE instrument. We confirmed its low-gravity atmosphere expected for an Upper Scorpius member (weak alkaline lines, strong VO absorption, peaked H-band pseudocontinuum). By comparison with spectroscopic standards, we derive a spectral type of L6 ± 1, and estimate a mass of ≈0.008-0.010 M⊙ for USco J155150.2-213457. The colors and spectral slope of this object resemble those of other young, cool members of Upper Scorpius and σ Orionis (~3 Myr) and field, high gravity dwarfs of related classification in contrast with the very red indices of field, low gravity, L-type dwarfs of intermediate age. USco J155150.2-213457, which does not show infrared flux excesses up to 4.5 μm, becomes one of the least massive and latest type objects known in the entire Upper Scorpius stellar association.

  13. Tree growth and forest ecosystem functioning in Eurasia under extreme climate conditions

    NASA Astrophysics Data System (ADS)

    Saurer, Matthias; Kirdyanov, Alexander; Prokushkin, Anatoly; Bryukhanova, Marina; Knorre, Anastasia; Nasyrov, Muhtor; Frank, David; Treydte, Kerstin; Sidorova, Olga; Siegwolf, Rolf

    2013-04-01

    The main goal of this study is to improve our understanding of the influence of a changing climate on trees in extreme conditions by a detailed analysis of the factors controlling tree-ring growth. We investigated forest ecosystems in regions that are very sensitive to climatic changes and where rapid and dramatic environmental and climatic changes are on-going, namely, the high latitude permafrost region in Central Siberia (Russia), the semi-arid dry areas in Central Asia (Uzbekistan) and high-altitude sites in the Alps (Switzerland). Tree-ring parameters studied were ring-width, density, cell number and structure and the ratio of carbon and oxygen isotopes. An important aspect of the work was the characterization of seasonal growth and water supply of trees. Intra-seasonal dynamics of tree-ring formation was correlated with monitored environmental factors, such as air and soil temperature and moisture, permafrost depth and the isotope composition of soil water, of precipitation, and of stream water. Intra-annual and long-term variability of the main tree-ring parameters were compared for the different regions. The results obtained help us to understand better tree-physiological processes valid under contrasting environmental conditions. For instance, the relationship between the onset of cell division in the cambium and the thermo-hydrological soil regime was used to determine the period of the year with the highest influence on the start of tree-ring formation. Seasonally resolved oxygen isotope depth profiles of soil water and concurrent xylem and leaf water measurements show the importance of time-lags between precipitation, leaf processes and growth. The data obtained are important for improving tree-ring growth models and estimating future tree growth under climate change. Funding: SNF SCOPES IZ73Z0_128035

  14. A Detailed Study of Contamination in Deep Rapid Searches for Gravitational Wave Optical Counterparts

    NASA Astrophysics Data System (ADS)

    Cowperthwaite, Philip; Berger, Edo; Chornock, Ryan; Fong, Wen-fai

    2015-01-01

    The first direct detection of gravitational waves (GW) by the Advanced LIGO/VIRGO (aLIGO/VIRGO) collaboration is expected to occur within the next few years. In order to maximize the science gains from such a detection it is essential that we identify an electromagnetic counterpart. One of the most promising counterparts is the so-called 'kilonovae,' a fast-evolving (t ~ days) and faint (z ~ 24 AB mag) optical transient powered by the radioactive decay of r-process elements generated in the merger. However, the poor initial localization of aLIGO/VIRGO (~ 100 sq. deg.) demand the use of wide-field telescopes. Furthermore, the cadences and depths used by current and future wide-field optical surveys (e.g. PTF/ZTF, PANStarrs, LSST) are sub-optimal for kilonovae detection. We present our attempts to tackle these issues by investigating the theoretical and practical issues associated with optical follow-up of an aLIGO/VIRGO GW event. This includes a systematic study of the potential contaminant population and their impact on kilonovae detectability in simulated observations. We show that kilonovae can remain separated from contaminants by the virtue of their red colors (i - z > 0.5) and short timescales. This theoretical analysis will be tested against observations obtained by the DECam wide-field imager on the CTIO Blanco 4m telescope. These data attempt to simulate the wide area coverage (~ 70 sq. deg.) and rapid cadence (two visits per night in i,z) necessary for targeted GW follow-up and will provide an excellent test bed for understanding the practical issues associated with this endeavor. This work is supported in part by the NSF GRFP grant DGE1144152.

  15. Lifted linear phase filter banks and the polyphase-with-advance representation

    SciTech Connect

    Brislawn, C. M.; Wohlberg, B. E.

    2004-01-01

    A matrix theory is developed for the noncausal polyphase-with-advance representation that underlies the theory of lifted perfect reconstruction filter banks and wavelet transforms as developed by Sweldens and Daubechies. This theory provides the fundamental lifting methodology employed in the ISO/IEC JPEG-2000 still image coding standard, which the authors helped to develop. Lifting structures for polyphase-with-advance filter banks are depicted in Figure 1. In the analysis bank of Figure 1(a), the first lifting step updates x{sub 0} with a filtered version of x{sub 1} and the second step updates x{sub 1} with a filtered version of x{sub 0}; gain factors 1/K and K normalize the lowpass- and highpass-filtered output subbands. Each of these steps is inverted by the corresponding operations in the synthesis bank shown in Figure 1(b). Lifting steps correspond to upper- or lower-triangular matrices, S{sub i}(z), in a cascade-form decomposition of the polyphase analysis matrix, H{sub a}(z). Lifting structures can also be implemented reversibly (i.e., losslessly in fixed-precision arithmetic) by rounding the lifting updates to integer values. Our treatment of the polyphase-with-advance representation develops an extensive matrix algebra framework that goes far beyond the results of. Specifically, we focus on analyzing and implementing linear phase two-channel filter banks via linear phase lifting cascade schemes. Whole-sample symmetric (WS) and half-sample symmetric (HS) linear phase filter banks are characterized completely in terms of the polyphase-with-advance representation. The theory benefits significantly from a number of new group-theoretic structures arising in the polyphase-with-advance matrix algebra from the lifting factorization of linear phase filter banks.

  16. VizieR Online Data Catalog: SLoWPoKES-II catalog (Dhital+, 2015)

    NASA Astrophysics Data System (ADS)

    Dhital, S.; West, A. A.; Stassun, K. G.; Schluns, K. J.; Massey, A. P.

    2015-11-01

    We have identified the Sloan Low-mass Wide Pairs of Kinematically Equivalent Systems (SLoWPoKES)-II catalog of 105537 wide, low-mass binaries without using proper motions. We extend the SLoWPoKES catalog (Paper I; Dhital et al. 2010, cat. J/AJ/139/2566) by identifying binary systems with angular separations of 1-20'' based entirely on SDSS photometry and astrometry. As in Paper I, we used the Catalog Archive Server query tool (CasJobs6; http://skyserver.sdss3.org/CasJobs/) to select the sample of low-mass stars from the SDSS-DR8 star table as having r-i>=0.3 and i-z>=0.2, consistent with spectral types of K5 or later. Following Paper I (Dhital et al. 2010, cat. J/AJ/139/2566) we classified candidate pairs with a probability of chance alignment Pf{<=}0.05 as real binaries. We note that this limit does not have any physical motivation but was chosen to minimize the number of spurious pairs. This cut results in 105537 M dwarf (dM)+MS (see Table3), 78 white dwarf (WD)+dM (see Table5), and 184 sdM+sdM (see Table6) binary systems with separations of 1-20''. Of the dM+MS binaries, 44 are very low-mass (VLM) binary candidates (see Table4), with colors redder than the median M7 dwarf for both components. This represents a significant increase over the SLoWPoKES catalog of 1342 common proper motion (CPM) binaries that we presented in Paper I (Dhital et al. 2010, cat. J/AJ/139/2566). The SLoWPoKES and SLoWPoKES-II catalogs are available on the Filtergraph portal (http://slowpokes.vanderbilt.edu/). (4 data files).

  17. Associations Between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999–2004

    PubMed Central

    Dinse, Gregg E.; Jusko, Todd A.; Whitt, Irene Z.; Co, Caroll A.; Parks, Christine G.; Satoh, Minoru; Chan, Edward K.L.; Rose, Kathryn M.; Walker, Nigel J.; Birnbaum, Linda S.; Zeldin, Darryl C.; Weinberg, Clarice R.; Miller, Frederick W.

    2015-01-01

    Background: Potential associations between background environmental chemical exposures and autoimmunity are understudied. Objectives: Our exploratory study investigated exposure to individual environmental chemicals and selected mixtures in relation to the presence of antinuclear antibodies (ANA), a widely used biomarker of autoimmunity, in a representative sample of the U.S. population. Methods: This cross-sectional analysis used data on 4,340 participants from the National Health and Nutrition Examination Survey (1999–2004), of whom 14% were ANA positive, to explore associations between ANA and concentrations of dioxins, dibenzofurans, polychlorinated biphenyls, organochlorines, organophosphates, phenols, metals, and other environmental exposures and metabolites measured in participants’ serum, whole blood, or urine. For dioxin-like compounds with toxic equivalency factors, we developed and applied a new statistical approach to study selected mixtures. Lognormal models and censored-data methods produced estimates of chemical associations with ANA in males, nulliparous females, and parous females; these estimates were adjusted for confounders and accommodated concentrations below detectable levels. Results: Several associations between chemical concentration and ANA positivity were observed, but only the association in males exposed to triclosan remained statistically significant after correcting for multiple comparisons (mean concentration ratio = 2.8; 95% CI: 1.8, 4.5; p < 0.00001). Conclusions: These data suggest that background levels of most xenobiotic exposures typical in the U.S. population are not strongly associated with ANA. Future studies should ideally reduce exposure misclassification by including prospective measurement of the chemicals of concern and should track changes in ANA and other autoantibodies over time. Citation: Dinse GE, Jusko TA, Whitt IZ, Co CA, Parks CG, Satoh M, Chan EKL, Rose KM, Walker NJ, Birnbaum LS, Zeldin DC, Weinberg CR

  18. The continuing story of SN IIb 2013df: new optical and IR observations and analysis

    NASA Astrophysics Data System (ADS)

    Szalai, Tamás; Vinkó, József; Nagy, Andrea P.; Silverman, Jeffrey M.; Wheeler, J. Craig; Dhungana, Govinda; Marion, G. Howie; Kehoe, Robert; Fox, Ori D.; Sárneczky, Krisztián; Marschalkó, Gábor; Bíró, Barna I.; Borkovits, Tamás; Hegedüs, Tibor; Szakáts, Róbert; Ferrante, Farley V.; Bányai, Evelin; Hodosán, Gabriella; Kelemen, János; Pál, András

    2016-08-01

    SN 2013df is a nearby Type IIb supernova that seems to be the spectroscopic twin of the well-known SN 1993J. Previous studies revealed many, but not all interesting properties of this event. Our goal was to add new understanding of both the early- and late-time phases of SN 2013df. Our spectral analysis is based on six optical spectra obtained with the 9.2 m Hobby-Eberly Telescope during the first month after explosion, complemented by a near-infrared spectrum. We applied the SYNAPPS spectral synthesis code to constrain the chemical composition and physical properties of the ejecta. A principal result is the identification of `high-velocity' He I lines in the early spectra of SN 2013df, manifest as the blue component of the double-troughed profile at ˜5650 Å. This finding, together with the lack of clear separation of H and He lines in velocity space, indicates that both H and He features form at the outer envelope during the early phases. We also obtained ground-based BVRI and g'r 'i'z' photometric data up to +45 d and unfiltered measurements with the ROTSE-IIIb telescope up to +168 d. From the modelling of the early-time quasi-bolometric light curve, we find Mej ˜ 3.2-4.6 M⊙ and Ekin ˜ 2.6-2.8 × 1051 erg for the initial ejecta mass and the initial kinetic energy, respectively, which agree well with the values derived from the separate modelling of the light-curve tail. Late-time mid-infrared excess indicates circumstellar interaction starting ˜1 yr after explosion, in accordance with previously published optical, X-ray, and radio data.

  19. A mutant of the nematophagous fungus Paecilomyces lilacinus (Thom) is a novel biocontrol agent for Sclerotinia sclerotiorum.

    PubMed

    Yang, Fan; Abdelnabby, Hazem; Xiao, Yannong

    2015-12-01

    Sclerotinia sclerotiorum causes severe stem rot and yield loss in oilseed rape (Brassica napus L.) and other crops worldwide. Extensive studies have been conducted on Paecilomyces lilacinus as a nematophagous bioagent. However, no reports stated the effect of P. lilacinus as a biocontrol agent against oilseed rape rot S. sclerotiorum. This study describes such effect in lab and field trials using the new transformant pt361 derived from the wild strain P. lilacinus 36-1. Unlike the wild-type strain, the mutant pt361 showed high antagonistic effect against S. Sclerotiorum A. Under lab conditions, the pt361 inhibited (65%) radial mycelial growth of S. sclerotiorum in dual culture test producing 5.9 mm inhibition zone IZ in front of the S. sclerotiorum colony. Moreover, the cell-free filtrate of pt361 culture showed strong inhibitory effects (60.3-100%) on mycelial growth of S. sclerotiorum. In leaf detached assay, pt361 significantly (p < 0.05) inhibited (40.4-97.9%) the extension of the leaf spots caused by S. sclerotiorum A at all tested concentrations. The genomic DNA sequences of the inserted T-DNA flanking obtained from pt361 strain was cloned, verified as a glycoside hydrolase 31 family by homologous analysis with other fungal strains, and named PGH31 (2556bp). Secondary structure prediction showed a domain (Glycoside hydrolase31). Three years field trial confirmed that the cell-free filtrates or spores suspension of pt361 achieved significant (p < 0.05) suppression of oilseed rape stem rot, promoted growth and increased yield compared to the control and exceeded, at dose 100%, the action of the fungicide procymidone(®). In conclusion, the mutant pt361 of P. lilacinus is a novel and promising biocontrol agent against oilseed rape Sclerotinia stem rot. PMID:26521137

  20. Some principles for formation of self-developing dichromate media

    NASA Astrophysics Data System (ADS)

    Sherstyuk, Valentin P.; Malov, Alexander N.; Maloletov, Sergei M.; Kalinkin, Vyacheslav V.

    1991-02-01

    The optical information recorded in dichromate gelatin (DCG) layers Induced the information of a latent. image Which rnder the action of water and alcohols transforms to a relief or Phase image. The action of water vapours ma appreciably increase diffraction efficiency. judging from the assumPtion that the introduction of multiatomic alcohols favours the retention of water'' moecu1es in a lager in the amount sufficient for deve1oment on its exposure and stabilization of chromium complexes1 a " self-development" regim has teen worked out. In this case the diffraction efficiency of recorded hc. 1ograms is c''ose to the theoretical limiting value for flatphase r''e c o rdI ng me (J i a. At present the occurence of a Primary latent holographic image (or structure) in dichromated gelatin (DCG) layers has been recognized The diffraction efficiency (DE) detected at a step of holographic recording is low (about 0. 1-IZ). It was shown earlier /j_ 2/ that the treatment bY water vaours or eXPOSUPC Of the layers under conditions of increased humidity results ma growth of DE up to the values enabling the use of DCG to record information in real time /3/j Latent image centres in exposed DC3 layers are predominantly chromium(V) compounds. It is particulary evidenced by the observed correlation between the rate of formation of Cr(V) compounds in a Photo process and the specific change in DE of a latent image /5/.

  1. CLASH: COMPLETE LENSING ANALYSIS OF THE LARGEST COSMIC LENS MACS J0717.5+3745 AND SURROUNDING STRUCTURES

    SciTech Connect

    Medezinski, Elinor; Lemze, Doron; Ford, Holland; Umetsu, Keiichi; Nonino, Mario; Zitrin, Adi; Broadhurst, Tom; Sayers, Jack; Czakon, Nicole; Waizmann, Jean-Claude; Meneghetti, Massimo; Koekemoer, Anton; Coe, Dan; Postman, Marc; Molino, Alberto; Melchior, Peter; Grillo, Claudio; and others

    2013-11-01

    The galaxy cluster MACS J0717.5+3745 (z = 0.55) is the largest known cosmic lens, with complex internal structures seen in deep X-ray, Sunyaev-Zel'dovich effect, and dynamical observations. We perform a combined weak- and strong-lensing analysis with wide-field BVR{sub c} i'z' Subaru/Suprime-Cam observations and 16-band Hubble Space Telescope observations taken as part of the Cluster Lensing And Supernova survey with Hubble. We find consistent weak distortion and magnification measurements of background galaxies and combine these signals to construct an optimally estimated radial mass profile of the cluster and its surrounding large-scale structure out to 5 Mpc h {sup –1}. We find consistency between strong-lensing and weak-lensing in the region where these independent data overlap, <500 kpc h {sup –1}. The two-dimensional weak-lensing map reveals a clear filamentary structure traced by distinct mass halos. We model the lensing shear field with nine halos, including the main cluster, corresponding to mass peaks detected above 2.5σ{sub κ}. The total mass of the cluster as determined by the different methods is M{sub vir} ≈ (2.8 ± 0.4) × 10{sup 15} M{sub ☉}. Although this is the most massive cluster known at z > 0.5, in terms of extreme value statistics, we conclude that the mass of MACS J0717.5+3745 by itself is not in serious tension with ΛCDM, representing only a ∼2σ departure above the maximum simulated halo mass at this redshift.

  2. [Expression and identification of eukaryotic expression vectors of Brucella melitensis lipoprotein OMP19].

    PubMed

    He, Zuoping; Luo, Peifang; Hu, Feihuan; Weng, Yunceng; Wang, Wenjing; Li, Chengyao

    2016-04-01

    Objective To construct eukaryotic expression vectors carrying Brucella melitensis outer membrane protein 19 (OMP19), express them in transfected Huh7.5.1 and JEG-3 cells, and analyze their role in cell apoptosis. Methods Brucella melitensis lipidated OMP19 (L-OMP19) gene and unlipidated OMP19 (U-OMP19) gene were amplified by PCR and inserted into the vector pZeroBack/blunt. The correct L-OMP19 and U-OMP19 genes verified by XbaI and BamHI double digestion and sequencing were cloned into the lentivirus expression vector pHAGE-CMV-MCS-IZsGreen to construct vectors pHAGE-L-OMP19 and pHAGE-U-OMP19, which were separately transfected into 293FT cells, Huh7.5.1 and JEG-3 cells. L-OMP19 and U-OMP19 in the cells were detected by Western blotting and immunofluorescence technique. Flow cytometry combined with annexin V-PE/7-AAD staining was used to detect the cell apoptosis. Results The lentiviral vectors pHAGE-L-OMP19 and pHAGE-U-OMP19 were constructed correctly and the recombinant lipoproteins L-OMP19 and U-OMP19 expressed in the above cells were well recognized by the specific antibodies against L-OMP19 in Western blotting and immunofluorescence technique. L-OMP19 and U-OMP19 induced JEG-3 cell death, but did not induce the apoptosis of Huh7.5.1 cells. Conclusion The eukaryotic expression vectors of L-OMP19 and U-OMP19 have been constructed successfully. Recombinant lipoproteins L-OMP19 and U-OMP19 expressed in cells have a good antigenicity, which could be used as experimental materials for the research on the relationship between host cells and lipoproteins in Brucella infection. PMID:27053612

  3. KELT-14b and KELT-15b: An Independent Discovery of WASP-122b and a New Hot Jupiter

    NASA Astrophysics Data System (ADS)

    Rodriguez, Joseph E.; Colón, Knicole D.; Stassun, Keivan G.; Wright, Duncan; Cargile, Phillip A.; Bayliss, Daniel; Pepper, Joshua; Collins, Karen A.; Kuhn, Rudolf B.; Lund, Michael B.; Siverd, Robert J.; Zhou, George; Gaudi, B. Scott; Tinney, C. G.; Penev, Kaloyan; Tan, T. G.; Stockdale, Chris; Curtis, Ivan A.; James, David; Udry, Stephane; Segransan, Damien; Bieryla, Allyson; Latham, David W.; Beatty, Thomas G.; Eastman, Jason D.; Myers, Gordon; Bartz, Jonathan; Bento, Joao; Jensen, Eric L. N.; Oberst, Thomas E.; Stevens, Daniel J.

    2016-06-01

    We report the discovery of KELT-14b and KELT-15b, two hot Jupiters from the KELT-South survey. KELT-14b, an independent discovery of the recently announced WASP-122b, is an inflated Jupiter mass planet that orbits a ∼ {5.0}-0.7+0.3 Gyr, V = 11.0, G2 star that is near the main sequence turnoff. The host star, KELT-14 (TYC 7638-981-1), has an inferred mass {M}* = {1.18}-0.07+0.05 M⊙ and radius {R}* = 1.37+/- -0.08 R⊙, and has {T}{{eff}} = {5802}-92+95 K, {log}{g}* = {4.23}-0.04+0.05 and [{{Fe}}/{{H}}] = 0.33 ± ‑0.09. The planet orbits with a period of 1.7100588 ± 0.0000025 days (T0 = 2457091.02863 ± 0.00047) and has a radius Rp = {1.52}-0.11+0.12 RJ and mass Mp = 1.196 ± 0.072 MJ, and the eccentricity is consistent with zero. KELT-15b is another inflated Jupiter mass planet that orbits a ∼{4.6}-0.4+0.5 Gyr, V = 11.2, G0 star (TYC 8146-86-1) that is near the “blue hook” stage of evolution prior to the Hertzsprung gap, and has an inferred mass {M}* = {1.181}-0.050+0.051 M⊙ and radius {R}* = {1.48}-0.04+0.09 R⊙, and {T}{{eff}} = {6003}-52+56 K, {log}{g}* = {4.17}-0.04+0.02 and [{{Fe}}/{{H}}] = 0.05 ± 0.03. The planet orbits on a period of 3.329441 ± 0.000016 days (T0 = 2457029.1663 ± 0.0073) and has a radius Rp = {1.443}-0.057+0.11 RJ and mass Mp = {0.91}-0.22+0.21 MJ and an eccentricity consistent with zero. KELT-14b has the second largest expected emission signal in the K-band for known transiting planets brighter than K < 10.5. Both KELT-14b and KELT-15b are predicted to have large enough emission signals that their secondary eclipses should be detectable using ground-based observatories.

  4. HAT-P-32b AND HAT-P-33b: TWO HIGHLY INFLATED HOT JUPITERS TRANSITING HIGH-JITTER STARS

    SciTech Connect

    Hartman, J. D.; Bakos, G. A.; Torres, G.; Latham, D. W.; Beky, B.; Quinn, S. N.; Esquerdo, G. A.; Noyes, R. W.; Sasselov, D. D.; Stefanik, R. P.; Szklenar, T.; Kovacs, Geza; Mazeh, T.; Shporer, A.; Marcy, G. W.; Howard, A. W.; Fischer, D. A.; Johnson, J. A.; Fernandez, J. M.; Lazar, J.

    2011-11-20

    We report the discovery of two exoplanets transiting high-jitter stars. HAT-P-32b orbits the bright V = 11.289 late-F-early-G dwarf star GSC 3281-00800, with a period P = 2.150008 {+-} 0.000001 d. The stellar and planetary masses and radii depend on the eccentricity of the system, which is poorly constrained due to the high-velocity jitter ({approx}80 m s{sup -1}). Assuming a circular orbit, the star has a mass of 1.16 {+-} 0.04 M{sub Sun} and radius of 1.22 {+-} 0.02 R{sub Sun }, while the planet has a mass of 0.860 {+-} 0.164 M{sub J} and a radius of 1.789 {+-} 0.025 R{sub J}. The second planet, HAT-P-33b, orbits the bright V = 11.188 late-F dwarf star GSC 2461-00988, with a period P = 3.474474 {+-} 0.000001 d. As for HAT-P-32, the stellar and planetary masses and radii of HAT-P-33 depend on the eccentricity, which is poorly constrained due to the high jitter ({approx}50 m s{sup -1}). In this case, spectral line bisector spans (BSs) are significantly anti-correlated with the radial velocity residuals, and we are able to use this correlation to reduce the residual rms to {approx}35 m s{sup -1}. We find that the star has a mass of 1.38 {+-} 0.04 M{sub Sun} and a radius of 1.64 {+-} 0.03 R{sub Sun} while the planet has a mass of 0.762 {+-} 0.101 M{sub J} and a radius of 1.686 {+-} 0.045 R{sub J} for an assumed circular orbit. Due to the large BS variations exhibited by both stars we rely on detailed modeling of the photometric light curves to rule out blend scenarios. Both planets are among the largest radii transiting planets discovered to date.

  5. Testing the performance of a VUV photoionization source on a double focussing mass spectrometer using alkanes and thiophenes

    NASA Astrophysics Data System (ADS)

    Bobeldijk, M.; Kistemaker, P. G.; Boon, J. J.

    1991-12-01

    The performance of a newly developed photoionization source in combination with a high resolution mass spectrometer is tested. The total ion currents for several linear alkanes (n-pentane to n-decane) and for some thiophenes (2-methylthiophene, 2,5-dimethylthiophene and 2-ethylthiophene) are measured at three fixed wavelengths: the Kr I (10.03 eV and 10.64 eV), Ar I (11.62 eV and 11.83 eV) and Ne I (16.67 eV and 16.85 eV) resonance lines. These total ion currents are compared with the data for the alkanes and thiophenes obtained with low energy (10.6 eV, 11.8 eV and 16.7eV) electron impact ionization on the same mass spectrometer. The loss in ion intensity at several positions throughout this instrument is determined for the photo-ionization source and for the electron impact ionization source. One out of every 1500 ions created in the photoionization source is measured by the detector. For the electron impact ionization source, one out of 180 ions is measured. The introduction of a five-element "Heddle" lens for the transfer of the ions from the photoion source to the mass analyser resulted in an approximately 1.5 fold loss in ion current. From the measured total ion intensities, the photoionization and electron impact ionization cross-sections at energies of 10.6 eV, 11.8 eV and 16.7 eV are calculated. The photoionization cross-section values of the linear alkanes are found to be in the range of 2.5 Mbarn to 355 Mbarn, and the electron impact ionization cross-section values are between 40 Mbarn and 735 Mbarn. The photoionization cross-section values of the thiophenes range from 4 Mbarn to 31 Mbarn, and the electron impact ionization cross-section values from 81 Mbarn to 760 Mbarn.

  6. Characterization of the nuclear ribosomal DNA units and phylogeny of Beta L. wild forms and cultivated beets.

    PubMed

    Santoni, S; Bervillé, A

    1992-03-01

    The nuclear rDNA units of species belonging to the genus Beta were characterized using heterologous probes of flax (entire unit and 25S) and sunflower (6.1-kb Eco fragment containing the 18S, the entire intergenic spacer (IGS) and a small piece of the 25S). The physical maps of one species from each section of the genus was constructed by localization of the EcoRI, BamHI, HindIII, KpnI and SacI restriction sites. For each species a single individual was used to obtain total DNA. The major unit length is 11 kb, but variant length units at 10.4, 10.7 and 11.3 kb were found as minor forms. However, some individuals carried the 10.4-kb or the 10.7-kb variant length unit as the major form. For the variant length units of one species the restriction sites were conserved, so that the variation in length occurred in the IGS. The EcoRI fragment corresponding to the intergenic spacer appeared to be the best indicator of variation. The variable sequence in the IGS sometimes generated new restriction sites for the Corollinae and mainly, did so, for the Vulgares relative to the Procumbentes. The variable sites were able, to differentiate the three sections and species within the sections. Corollinae species belong to two different groups according to the absence or the presence of the BamHI (B4) site. The Vulgares species contain several unit types. We proposed that all the unit types derived from a unique unit, V-11-2.3, by unequal crossing-overs or conversion. We also supposed a homogenization mechanism because we found individuals homogeneous for every unit type. Among the cultivated beets, all the root beets contain only one rDNA unit type, V-11-2.9. Thus, we supposed that the common unit type of cultivated beets either brings a physiological advantage or is strictly linked to a favorable allele. It is likely that the rDNA unit of B. maritima were eliminated from sugar beet by the breeding process since they were not recovered. Whatever the process, we deduced that all the

  7. CyberShake: Running Seismic Hazard Workflows on Distributed HPC Resources

    NASA Astrophysics Data System (ADS)

    Callaghan, S.; Maechling, P. J.; Graves, R. W.; Gill, D.; Olsen, K. B.; Milner, K. R.; Yu, J.; Jordan, T. H.

    2013-12-01

    As part of its program of earthquake system science research, the Southern California Earthquake Center (SCEC) has developed a simulation platform, CyberShake, to perform physics-based probabilistic seismic hazard analysis (PSHA) using 3D deterministic wave propagation simulations. CyberShake performs PSHA by simulating a tensor-valued wavefield of Strain Green Tensors, and then using seismic reciprocity to calculate synthetic seismograms for about 415,000 events per site of interest. These seismograms are processed to compute ground motion intensity measures, which are then combined with probabilities from an earthquake rupture forecast to produce a site-specific hazard curve. Seismic hazard curves for hundreds of sites in a region can be used to calculate a seismic hazard map, representing the seismic hazard for a region. We present a recently completed PHSA study in which we calculated four CyberShake seismic hazard maps for the Southern California area to compare how CyberShake hazard results are affected by different SGT computational codes (AWP-ODC and AWP-RWG) and different community velocity models (Community Velocity Model - SCEC (CVM-S4) v11.11 and Community Velocity Model - Harvard (CVM-H) v11.9). We present our approach to running workflow applications on distributed HPC resources, including systems without support for remote job submission. We show how our approach extends the benefits of scientific workflows, such as job and data management, to large-scale applications on Track 1 and Leadership class open-science HPC resources. We used our distributed workflow approach to perform CyberShake Study 13.4 on two new NSF open-science HPC computing resources, Blue Waters and Stampede, executing over 470 million tasks to calculate physics-based hazard curves for 286 locations in the Southern California region. For each location, we calculated seismic hazard curves with two different community velocity models and two different SGT codes, resulting in over

  8. Exchange variation of zero-field splittings in [Fe 4S 4] + clusters of ferredoxins with high-spin S=3/2 ground state

    NASA Astrophysics Data System (ADS)

    Belinsky, Moisey I.

    2000-04-01

    The spin-coupling model of zero-field splitting (ZFS) of tetrameric mixed-valent and monovalent clusters is developed. The <| ŝi0(2)|> matrix elements of the individual ZFS tensor operator of the second rank were calculated for tetramers of the general type in the representation of the total and intermediate spins. The spin-dependent correlations between ZFS parameters D S of the cluster states S and D i of individual ions s i were obtained for [4Fe-4S] + centers of native systems and synthetic model compounds with the high-spin Sgr=3/2 ground state. It was shown that the single-particle spin parameters f i=<| ŝiz2-s i(s i+1)/3|>/<| Ŝz2-S(S+1)/3|> of the [Fe 3(II)Fe(III)] center essentially depend on the total, intermediate and local spins and on the exchange parameters. In the spin schemes with fixed intermediate spins, the correlation between the cluster total spin ZFS parameters, D S, and the individual ZFS parameters, D i, are determined by the total, intermediate and individual spins. Anisotropic cluster ZFS parameters D S strongly depend on isotropic Heisenberg exchange and double exchange inter-ion interactions due to exchange mixing of the states with different intermediate spins. It was shown that the cluster ZFS parameters D S, for the states with S=3/2, change their values and sign under the variation of the Heisenberg exchange and double exchange parameters during the cluster deformation. The single-particle ZFS parameters D i and the exchange effects determine the observed strong positive ( DS=1.5-6 cm -1) and negative ( DS=-1.7 to -5 cm -1) cluster ZFS splittings of the ground Sgr=3/2 states of the [4Fe-4S] + clusters. Positive (negative) cluster ZFS parameters D S correspond to negative (positive) individual ZFS parameters D1-3 [Fe(II)]. The theory explains the observation of small negative effective hyperfine constants A i for the Sgr=3/2 clusters with positive and negative cluster ZFS parameters D S. The correlations between the individual and

  9. Gas-Phase Photoemission With Soft X-Rays: Cross Sections And Angular Distributions

    NASA Astrophysics Data System (ADS)

    Shirley, D. A.; Kobrin, P. H.; Truesdale, C. M.; Lindle, D. W.; F errett, T. A.; Heimann, P. A.; Becker, U.; Kerkhoff, H. G.; Southworth, S. H.

    1984-03-01

    A summary is presented of typical gas-phase photoemission studies based on synchrotron radiation in the 50-5000 eV range, using beam lines at the Stanford Synchrotron Radiation Laboratory. Three topics are addressed: atomic inner-shell photoelectron cross sections and asymmetries, correlation peaks in rare gases, and core-level shape resonances in molecules. Photoelectron cross-section a(nZ) and asymmetry-parameter a(n0 studies in mercury vapor at photon energies up to 270 eV (up to 600 eV for a4f) extend coverage of these parameters to n<5 and 5<3. Comparison with Dirac-Slater and relativistic random-phase approximation calculations reveals systematic discrepancies. For example, distinct Cooper minima in a(n iZ,) are observed but not predicted, while predicted a(n9) values are typically too high. Correlation satellites have been studied for the K shells of helium (hv = 68-90 eV), neon (hv = 870-960 eV) and argon (hv = 3200-3320 eV). In helium the n=2 satellite peak was shown to have mainly 2p character at threshold, and its asymmetry was measured through the autoionizing resonance region. Tentative evidence was obtained that the neon satellites are less intense near threshold than in the high-energy limit, and that their intensities stay constant or decrease with increasing energy near threshold. A new satellite was observed in argon at 24.6 eV which appears to increase in intensity with energy. Molecular core-level shape resonances were observed for the first time by photoemission, yielding a(hv) and a(hv) for core levels from 180 eV binding energy (S 2p in SF6 and OCS) through C is in CO, CO2 and CF4, N ls in N2 and NO, and 0 is in CO and CO2 to 2490 eV (S ls in SF6). Several conclusions can be drawn about the photoelectron and Auger cross sections and asymmetry parameters.

  10. Level repulsion exponent β for many-body localization transitions and for Anderson localization transitions via Dyson Brownian motion

    NASA Astrophysics Data System (ADS)

    Monthus, Cécile

    2016-03-01

    The generalization of the Dyson Brownian motion approach of random matrices to Anderson localization (AL) models (Chalker et al 1996 Phys. Rev. Lett. 77 554) and to many-body localization (MBL) Hamiltonians (Serbyn and Moore 2015 arXiv:1508.07293) is revisited to extract the level repulsion exponent β, where β =1 in the delocalized phase governed by the Wigner-Dyson statistics, β =0 , in the localized phase governed by the Poisson statistics, and 0<{βc}<1 at the critical point. The idea is that the Gaussian disorder variables h i are promoted to Gaussian stationary processes h i (t) in order to sample the disorder stationary distribution with some time correlation τ. The statistics of energy levels can then be studied via Langevin and Fokker-Planck equations. For the MBL quantum spin Hamiltonian with random fields h i , we obtain β =2qn,n+1\\text{EA}(N)/qn,n\\text{EA}(N) in terms of the Edwards-Anderson matrix qnm\\text{EA}(N)\\equiv \\frac{1}{N}{\\sum}i=1N|< {φn}|σ iz|{φm}> {{|}2} for the same eigenstate m  =  n and for consecutive eigenstates m  =  n  +  1. For the Anderson localization tight-binding Hamiltonian with random on-site energies h i , we find β =2{{Y}n,n+1}(N)/≤ft({{Y}n,n}(N)-{{Y}n,n+1}(N)\\right) in terms of the density correlation matrix {{Y}nm}(N)\\equiv {\\sum}i=1N|< {φn}|i> {{|}2}|< i|{φm}> {{|}2} for consecutive eigenstates m  =  n  +  1, while the diagonal element m  =  n corresponds to the inverse participation ratio {{Y}nn}(N)\\equiv {\\sum}i=1N|< {φn}|i> {{|}4} of the eigenstate |{φn}> .

  11. New Perspectives on Ophiolite Formation: Evidence from Ultrahigh Pressure (UHP), Highly Reduced and Crustal-type Minerals in Podiform Chromitites

    NASA Astrophysics Data System (ADS)

    Robinson, P. T.; Yang, J.

    2014-12-01

    Separated and in situ ultrahigh pressure (UHP), highly reduced and crustal-type minerals are common in podiform chromitites of the Luobusa and Dongqiao ophiolites, Tibet and the Ray-Iz ophiolite of the Polar Urals, Russia. Highly reduced and crustal-type minerals have also been recovered from the Oman ophiolite. UHP minerals include diamond, coesite-stishovite and kyanite, whereas highly reduced minerals are mainly moissanite (SiC), native elements (e.g., Si, Fe, Cr, Al, Ti, Mn, W, Ta) and a wide variety of metallic alloys. Crustal-type minerals are represented by various combinations of zircon, corundum, almandine garnet, kyanite, andalusite, quartz, K-feldspar, plagioclase, apatite, amphibole, rutile, and titanite. Most in-situ grains are hosted in small, circular to irregular patches of amorphous carbon within grains of magnesiochromite, indicating the former presence of a C-rich fluid, either during or after crystallization of the chromite. The recovered zircons are typically rounded to sub-rounded grains with complex internal structures indicating polyphase growth. Their trace element contents and low-pressure inclusion assemblages (quartz, muscovite, K-feldspar, apatite, ilmenite, rutile) indicate a continental crustal origin. The zircons have SIMS U-Pb ages that are generally much older than the host ophiolite (total range: 90 to 2500 Ma). The presence of numerous crustal minerals, particularly zircon, suggests derivation from metasedimentary rocks subducted into the mantle. The preservation of UHP, highly reduced and crustal-type minerals in chromitites implies effective isolation from the mafic melts that formed the ophiolites and chromitites. Clearly, the formation of ophiolites and podiform chromitites must be a complex, multistage process involving crystallization of magnesiochromite grains at depth in the upper mantle, upwelling of the host peridotites and chromitites, capture of mantle wedges above suprasubduction zones, further crystallization and

  12. Multicolor surface photometry of a sample of low luminosity radio galaxies

    NASA Astrophysics Data System (ADS)

    Sahu, Sheetal Kumar; Pandey, S. K.; Chakradhari, N. K.; Baburao Pandge, Mahadev

    2015-08-01

    We present a detailed multiband photometric study of five galaxies, selected from a sample of low luminosity early-type galaxies from B2 sample, which have mpg = 15.7, mV = 16.5, redshifts up to 0.2, radio powers P408 = 1023 - 1026.5 W Hz-1 and between 1022 - 1025 W Hz-1 at 1.4 GHz. We have used observed BVR and Hα images from IGO 2m telescope (Pune, India) and 2m HCT, Indian Astronomical Observatory (IAO Hanle, India), and archival multiband data from SDSS (ugriz), 2MASS (JHKs ), WISE, Spitzer (mid-IR), XMM, CHANDRA (X-ray), UV (GALEX) and radio from VLA, IRAM for this study.We used standard technique of surface photometry by fitting ellipses to the isophotes for studying the distribution of light in the galaxies by studying their surface brightness profiles, ellipticity profiles, position angle profiles, variation of center of isophotes along semi-major axis, shapes of isophotes, radial color gradients, twists in isophotes and fine structure variations from smooth light profile. The obtained surface brightness profiles are fitted to the core-Sersic model for decomposing the galaxy light profiles and quantify the radial stellar distributions of the sample galaxies.The multiband color index profiles, e.g. u-g, g-r, r-i, i-z, B-R, B-V, J-Hs , J-Ks , H-Ks , R-Ks , 3.4-4.6 μm, 4.6-12 μm (mid-IR) and FUV-NUV(UV), are obtained and combined with various maps e.g . unsharp-masked images, residual maps, quotient maps, dust extinction maps, Hα emission maps, CO intensity maps, diffuse X-ray emission maps and extinction curves of the galaxies to study the morphology, properties and physical correlations of different phases (e.g cool gas, dust, ionized gas and hot gases) of Inter Stellar Medium and to examine various star formation related processes in the galaxies.

  13. Impact of Forest Fires on Tree-Ring δ13C and δ18O of Gmelinii Larch in the Permafrost Zone

    NASA Astrophysics Data System (ADS)

    Knorre, Anastasia; Kirdyanov, Alexander; Saurer, Matthias; Siegwolf, Rolf; Sidorova, Olga; Prokushkin, Anatoly

    2013-04-01

    the frequency and intensity of fires is expected to increase. Funding: SNF SCOPES IZ73Z0_128035 and RFBR-04-12-00542

  14. THE GAS CONSUMPTION HISTORY TO REDSHIFT 4

    SciTech Connect

    Bauermeister, Amber; Blitz, Leo; Ma, Chung-Pei E-mail: blitz@berkeley.ed

    2010-07-01

    Using the observations of the star formation rate (SFR) and H I densities to z {approx} 4, with measurements of the molecular gas depletion rate (MGDR) and local density of H{sub 2} at z = 0, we derive the history of the gas consumption by star formation to z {approx} 4. We find that closed-box models in which H{sub 2} is not replenished by H I require improbably large increases in {rho}(H{sub 2}) and a decrease in the MGDR with lookback time that is inconsistent with observations. Allowing the H{sub 2} used in star formation to be replenished by H I does not alleviate the problem because observations show that there is very little evolution of {rho}{sub H{sub I}}(z) from z = 0 to z = 4. We show that to be consistent with observational constraints, star formation on cosmic timescales must be fueled by intergalactic ionized gas, which may come from either accretion of gas through cold (but ionized) flows, or from ionized gas associated with accretion of dark matter halos. We constrain the rate at which the extragalactic ionized gas must be converted into H I and ultimately into H{sub 2}. The ionized gas inflow rate roughly traces the SFR density: about 1-2 x 10{sup 8} M{sub sun} Gyr{sup -1} Mpc{sup -3} from z {approx_equal} 1-4, decreasing by about an order of magnitude from z = 1 to z = 0 with details depending largely on MGDR(t). All models considered require the volume-averaged density of {rho}{sub H{sub 2}} to increase by a factor of 1.5-10 to z {approx} 1.5 over the currently measured value. Because the molecular gas must reside in galaxies, it implies that galaxies at high-z must, on average, be more molecule rich than they are at the present epoch, which is consistent with observations. These quantitative results, derived solely from observations, agree well with cosmological simulations.

  15. The integrated analyses of digital field mapping techniques and traditional field methods: implications from the Burdur-Fethiye Shear Zone, SW Turkey as a case-study

    NASA Astrophysics Data System (ADS)

    Elitez, İrem; Yaltırak, Cenk; Zabcı, Cengiz; Şahin, Murat

    2015-04-01

    The precise geological mapping is one of the most important issues in geological studies. Documenting the spatial distribution of geological bodies and their contacts play a crucial role on interpreting the tectonic evolution of any region. Although the traditional field techniques are still accepted to be the most fundamental tools in construction of geological maps, we suggest that the integration of digital technologies to the classical methods significantly increases the resolution and the quality of such products. We simply follow the following steps in integration of the digital data with the traditional field observations. First, we create the digital elevation model (DEM) of the region of interest by interpolating the digital contours of 1:25000 scale topographic maps to 10 m of ground pixel resolution. The non-commercial Google Earth satellite imagery and geological maps of previous studies are draped over the interpolated DEMs in the second stage. The integration of all spatial data is done by using the market leading GIS software, ESRI ArcGIS. We make the preliminary interpretation of major structures as tectonic lineaments and stratigraphic contacts. These preliminary maps are controlled and precisely coordinated during the field studies by using mobile tablets and/or phablets with GPS receivers. The same devices are also used in measuring and recording the geologic structures of the study region. Finally, all digitally collected measurements and observations are added to the GIS database and we finalise our geological map with all available information. We applied this integrated method to map the Burdur-Fethiye Shear Zone (BFSZ) in the southwest Turkey. The BFSZ is an active sinistral 60-to-90 km-wide shear zone, which prolongs about 300 km-long between Suhut-Cay in the northeast and Köyceğiz Lake-Kalkan in the southwest on land. The numerous studies suggest contradictory models not only about the evolution but also about the fault geometry of this

  16. Ultra-reducing conditions in average mantle peridotites and in podiform chromitites: a thermodynamic model for moissanite (SiC) formation

    NASA Astrophysics Data System (ADS)

    Golubkova, Anastasia; Schmidt, Max W.; Connolly, James A. D.

    2016-05-01

    Natural moissanite (SiC) is reported from mantle-derived samples ranging from lithospheric mantle keel diamonds to serpentinites to podiform chromitites in ophiolites related to suprasubduction zone settings (Luobusa, Dongqiao, Semail, and Ray-Iz). To simulate ultra-reducing conditions and the formation of moissanite, we compiled thermodynamic data for alloys (Fe-Si-C and Fe-Cr), carbides (Fe3C, Fe7C3, SiC), and Fe-silicides; these data were augmented by commonly used thermodynamic data for silicates and oxides. Computed phase diagram sections then constrain the P- T- fO2 conditions of SiC stability in the upper mantle. Our results demonstrate that: Moissanite only occurs at oxygen fugacities 6.5-7.5 log units below the iron-wustite buffer; moissanite and chromite cannot stably coexist; increasing pressure does not lead to the stability of this mineral pair; and silicates that coexist with moissanite have X Mg > 0.99. At upper mantle conditions, chromite reduces to Fe-Cr alloy at fO2 values 3.7-5.3 log units above the moissanite-olivine-(ortho)pyroxene-carbon (graphite or diamond) buffer (MOOC). The occurrence of SiC in chromitites and the absence of domains with almost Fe-free silicates suggest that ultra-reducing conditions allowing for SiC are confined to grain scale microenvironments. In contrast to previous ultra-high-pressure and/or temperature hypotheses for SiC origin, we postulate a low to moderate temperature mechanism, which operates via ultra-reducing fluids. In this model, graphite-/diamond-saturated moderately reducing fluids evolve in chemical isolation from the bulk rock to ultra-reducing methane-dominated fluids by sequestering H2O into hydrous phases (serpentine, brucite, phase A). Carbon isotope compositions of moissanite are consistent with an origin of such fluids from sediments originally rich in organic compounds. Findings of SiC within rocks mostly comprised by hydrous phases (serpentine + brucite) support this model. Both the hydrous phases

  17. The statistical geoportal and the ``cartographic added value'' - creation of the spatial knowledge infrastructure

    NASA Astrophysics Data System (ADS)

    Fiedukowicz, Anna; Gasiorowski, Jedrzej; Kowalski, Paweł; Olszewski, Robert; Pillich-Kolipinska, Agata

    2012-11-01

    The wide access to source data, published by numerous websites, results in situation, when information acquisition is not a problem any more. The real problem is how to transform information in the useful knowledge. Cartographic method of research, dealing with spatial data, has been serving this purpose for many years. Nowadays, it allows conducting analyses at the high complexity level, thanks to the intense development in IT technologies, The vast majority of analytic methods utilizing the so-called data mining and data enrichment techniques, however, concerns non-spatial data. According to the Authors, utilizing those techniques in spatial data analysis (including analysis based on statistical data with spatial reference), would allow the evolution of the Spatial Information Infrastructure (SII) into the Spatial Knowledge Infrastructure (SKI). The SKI development would benefit from the existence of statistical geoportal. Its proposed functionality, consisting of data analysis as well as visualization, is outlined in the article. The examples of geostatistical analyses (ANOVA and the regression model considering the spatial neighborhood), possible to implement in such portal and allowing to produce the “cartographic added value”, are also presented here. Szeroki dostep do danych zródłowych publikowanych w licznych serwisach internetowych sprawia, iz współczesnie problemem jest nie pozyskanie informacji, lecz umiejetne przekształcenie jej w uzyteczna wiedze. Kartograficzna metoda badan, która od wielu lat słuzy temu celowi w odniesieniu do danych przestrzennych, zyskuje dzis nowe oblicze - pozwala na wykonywanie złozonych analiz dzieki wykorzystaniu intensywnego rozwoju technologii informatycznych. Znaczaca wiekszosc zastosowan metod analitycznych tzw. eksploracyjnej analizy danych (data mining) i ich "wzbogacania” (data enrichment) dotyczy jednakze

  18. The Importance of Caveolin-1 as Key-Regulator of Three-Dimensional Growth in Thyroid Cancer Cells Cultured under Real and Simulated Microgravity Conditions

    PubMed Central

    Riwaldt, Stefan; Bauer, Johann; Pietsch, Jessica; Braun, Markus; Segerer, Jürgen; Schwarzwälder, Achim; Corydon, Thomas J.; Infanger, Manfred; Grimm, Daniela

    2015-01-01

    We recently demonstrated that the CAV1 gene was down-regulated, when poorly differentiated thyroid FTC-133 cancer cells formed spheroids under simulated microgravity conditions. Here, we present evidence that the caveolin-1 protein is involved in the inhibition of spheroid formation, when confluent monolayers are exposed to microgravity. The evidence is based on proteins detected in cells and their supernatants of the recent spaceflight experiment: “NanoRacks-CellBox-Thyroid Cancer”. The culture supernatant had been collected in a special container adjacent to the flight hardware incubation chamber and stored at low temperature until it was analyzed by Multi-Analyte Profiling (MAP) technology, while the cells remaining in the incubation chamber were fixed by RNAlater and examined by mass spectrometry. The soluble proteins identified by MAP were investigated in regard to their mutual interactions and their influence on proteins, which were associated with the cells secreting the soluble proteins and had been identified in a preceding study. A Pathway Studio v.11 analysis of the soluble and cell-associated proteins together with protein kinase C alpha (PRKCA) suggests that caveolin-1 is involved, when plasminogen enriched in the extracellular space is not activated and the vascular cellular adhesion molecule (VCAM-1) mediated cell–cell adhesion is simultaneously strengthened and activated PRKCA is recruited in caveolae, while the thyroid cancer cells do not form spheroids. PMID:26633361

  19. An Occultation by Saturn's Rings on 1991 October 2-3 October 2-3 Observed with the Hubble Space Telescope

    NASA Technical Reports Server (NTRS)

    Elliot, J. L.; Bosh, A. S.; Cooke, M. L.; Bless, R. C.; Nelson, M. J.; Percival, J. W.; Taylor, M. J.; Dolan, J. F.; Robinson, E. L.; Van Citters, G. W.

    1993-01-01

    An occultation of the star GSC 6323-01396 (V = 11.9) by Saturn's rings was observed with the High-Speed Photometer on the Hubble Space Telescope (HST) on 1991 October 2-3. This occultation occurred when Saturn was near a stationary point, so the apparent motion of Saturn relative to the star was dominated by the HST orbital motion (8 km/s). Data were recorded simultaneously at effective wavelengths of 3200 and 7500 A, with an integration time of 0.15 s. Fifteen segments of occultation data, totaling 6.8 h, were recorded in 13 successive orbits during the 20.0 h interval from UTC 1991 October 2, 19:35 until UTC 1991 October 3, 15:35. Occultations by 43 different features throughout the classical rings were unambiguously identified in the light curve, with a second occultation by 24 of them occurring due to spacecraft orbital parallax during this extremely slow event. Occultation times for features currently presumed circular were measured and employed in a geometrical model for the rings. This model, relating the observed occultation times to feature radii and longitudes, is presented here and is used in a least-squares fit for the pole direction and radius scale of Saturn's ring system.

  20. Antigenic Diversity and Distribution of Rabies Virus in Mexico

    PubMed Central

    Velasco-Villa, Andrés; Gómez-Sierra, Mauricio; Hernández-Rodríguez, Gustavo; Juárez-Islas, Victor; Meléndez-Félix, Alejandra; Vargas-Pino, Fernando; Velázquez-Monroy, Oscar; Flisser, Ana

    2002-01-01

    Rabies remains a public health problem in the Americas because of the great diversity of wild reservoirs that maintain the virus in nature. Here we report the antigenic characterization of 254 rabies viruses isolated from 148 nonreservoir and 106 reservoir hosts collected in 27 states of Mexico. Nine out of 11 antigenic variants previously reported in the United States were detected in Mexico by using the limited panel of monoclonal antibodies donated by the Centers for Disease Control and Prevention. Some rabies virus variants were isolated from their natural reservoirs, which were also taxonomically identified. Terrestrial reservoirs included stray dogs with V1, Urocyon cineroargenteus (gray foxes) with V7, and two subspecies of Spilogale putorius (spotted skunks) with different viral variants (V8 and V10). Aerial hosts included Tadarida brasiliensis mexicana and Desmodus rotundus, which harbored V9 and V4 and harbored V11, respectively. All variants, with the exception of V9, were isolated from nonreservoir hosts, while V3, V4, and V5 were not isolated from their natural reservoirs but only from livestock. Rabies virus antigenic typing allowed us to determine rabies reservoirs and their distribution in Mexico, data which will probably improve prevention and control of the illness in humans and in the reservoir hosts. PMID:11880422

  1. B2H6 PLAD Doped PMOS Device Performance

    SciTech Connect

    Fang, Z.; Miller, T.; Winder, E.; Persing, H.; Arevalo, E.; Gupta, A.; Parrill, T.; Singh, V.; Qin, S.; McTeer, A.

    2006-11-13

    Plasma doping (PLAD) achieves high wafer throughput by directly extracting ions across the plasma sheath. PLAD profiles are typically surface peaked instead of retrograde as obtained from beamline (BL) implant. It may require optimization of PLAD energy and dose in order to match BL doping results. From device optimization point of view, it is necessary to understand the impact of doping parameters to device characteristics. In this paper we present the PMOS device performance with the poly gate and source drain (SD) implants carried out using B2H6 PLAD. The BL control conditions are 2-5 keV 11B+ 4-6x1015 cm-2. Equivalent device performance for p+ poly gate doping is obtained using PLAD with B2H6 / H2. In SD doping using same gas mixture, nearly 50% reduction in SD contact resistance is observed in the PLAD splits. The reduction in SD contact resistance leads to 10-15% increase in device on-current, hence demonstrating the process advantages of using PLAD in addition to having a high wafer throughput.

  2. Photometric Detection of ``Hot--Jupiters'' with a FAME--like Space Astrometry Mission

    NASA Astrophysics Data System (ADS)

    Gaume, R. A.; Olling, R. P.

    2002-12-01

    Astrometric and photometric data from space missions with designs similar to the Full--sky Astrometric Mapping Explorer (FAME) can be used to determine the properties of 40 million stars in the greater solar neighborhood (d <= 3 kpc) brighter than V=15--16 mag. Such a FAME--like mission would scan the sky for about 5 years, and cover each point on the sky once per day, on average. The ≈ 106 stars at the bright end of the FAME magnitude range (V=11 mag and brighter) have photometric accuracy better than about 0.003 mag (3 mmag) per focal--plane transit. This sample is ideally suited to look for transiting ``hot--jupiters'' that have transit depths of about 15 mmag. We present preliminary investigations on the likelihood of detection and characterization of such planetary transits. We estimate that a FAME--like mission will discover roughly 400 transiting ``hot--jupiters'' around stars in the V=9-11 magnitude range. Such bright systems are well--suited for follow-up investigations.

  3. Pathogenicity and Complete Genome Characterization of Fowl Adenoviruses Isolated from Chickens Associated with Inclusion Body Hepatitis and Hydropericardium Syndrome in China

    PubMed Central

    Zhao, Jing; Zhong, Qi; Zhao, Ye; Hu, Yan-xin; Zhang, Guo-zhong

    2015-01-01

    In this study, we determined and genetically characterized three fowl adenoviruses isolated from chickens with inclusion body hepatitis (IBH) and hydropericardium syndrome (HPS) in China and assessed their pathogenicity. The full genome of HBQ12, BJH13 and JSJ13 was found to be 44,081, 43,966 and 43,756 nucleotides long, respectively. Sequence alignment and phylogenetic analysis revealed that strain HBQ12 and BJH13 were clustered together belonging to fowl adenoviruses D species and serotyped as FAdV-11, whereas strain JSJ13 was classified into fowl adenoviruses C species and serotyped as FAdV-4. To our knowledge, this is the first report of FAdV-4 strain circulating in China. The pathogenicity test showed that mortality for chickens infected with HBQ12 and JSJ13 within 21 days post infection (dpi) was 8.6% and 28.6%, respectively. Necropsy displayed mild or severe hepatitis and hydropericardium at 3 and 5 dpi as well as dead chickens. Viral DNA was detected in almost all tissues sampled from dead chickens. These results revealed that fowl adenovirus strains HBQ12 and JSJ13 are capable of causing IBH and HPS in chickens, indicating that preventive measures against FAdV infection on poultry farms should be implemented in China. PMID:26167857

  4. Ac loss modelling and measurement of superconducting transformers with coated-conductor Roebel-cable in low-voltage winding

    NASA Astrophysics Data System (ADS)

    Pardo, Enric; Staines, Mike; Jiang, Zhenan; Glasson, Neil

    2015-11-01

    Power transformers using a high temperature superconductor (HTS) ReBCO coated conductor and liquid nitrogen dielectric have many potential advantages over conventional transformers. The ac loss in the windings complicates the cryogenics and reduces the efficiency, and hence it needs to be predicted in its design, usually by numerical calculations. This article presents detailed modelling of superconducting transformers with Roebel cable in the low-voltage (LV) winding and a high-voltage (HV) winding with more than 1000 turns. First, we model a 1 MVA 11 kV/415 V 3-phase transformer. The Roebel cable solenoid forming the LV winding is also analyzed as a stand-alone coil. Agreement between calculations and experiments of the 1 MVA transformer supports the model validity for a larger tentative 40 MVA 110 kV/11 kV 3-phase transformer design. We found that the ac loss in each winding is much lower when it is inserted in the transformer than as a stand-alone coil. The ac loss in the 1 and 40 MVA transformers is dominated by the LV and HV windings, respectively. Finally, the ratio of total loss over rated power of the 40 MVA transformer is reduced below 40% of that of the 1 MVA transformer. In conclusion, the modelling tool in this work can reliably predict the ac loss in real power applications.

  5. Exoplanet observations with GTC

    NASA Astrophysics Data System (ADS)

    Pallé, Enric

    2015-12-01

    Our group is presently conducting an observational campaign, using the 10-meter Gran Telescopio Canarias (GTC), to obtain the transmission spectrum of several exoplanets during a transit event. The GTC instrument OSIRIS is used in its long-slit spectroscopic mode, covering the spectral range of 520-1040 nm, and observations are taken using a set of custom-built slits of various, broad, widths. We integrate the stellar flux of both stars in different wavelength regions producing several light curves and fit transit models in order to obtain the star-to-planet radius ratio Rp/Rs across wavelength. A Markov Chain Monte Carlo (MCMC) Bayesian approach is used for the transit fitting. We will show that with our instrumental setup, OSIRIS has been able to reach precisions down to 250 ppm (WASP-48b, V=11.06 mag) for each color light curve 10 nm wide, in a single transit. And accuracies of the order of 500ppm can be obtained for objects with V=16. Central transit timing accuracies have been measured down to 6 seconds.Here, we will present refined planet parameters, the detection of planet color signatures, and the transmission spectra of a set of know and unpublished transiting exoplanets. We will also discuss the capabilities and limitations of GTC with current and future instrumentation, and the role of GTC as tool for the follow up of faint exoplanet targets.

  6. In vitro comparative study of manual and mechanical rotary instrumentation of root canals using computed tomography.

    PubMed

    Limongi, Orlando; de Albuquerque, Diana Santana; Baratto Filho, Flares; Vanni, José Roberto; de Oliveira, Elias P Motcy; Barletta, Fernando Branco

    2007-01-01

    This in vitro study compared, using computed tomography (CT), the amount of dentin removed from root canal walls by manual and mechanical rotary instrumentation techniques. Forty mandibular incisors with dental crown and a single canal were selected. The teeth were randomly assigned to two groups, according to the technique used for root canal preparation: Group I - manual instrumentation with stainless steel files; Group II - mechanical instrumentation with RaCe rotary nickel-titanium instruments. In each tooth, root dentin thickness of the buccal, lingual, mesial and distal surfaces in the apical, middle and cervical thirds of the canal was measured (in mm) using a multislice CT scanner (Siemens Emotion, Duo). Data were stored in the SPSS v. 11.5 and SigmaPlot 2001 v. 7.101 softwares. After crown opening, working length was determined, root canals were instrumented and new CT scans were taken for assessment of root dentin thickness. Pre- and post-instrumentation data were compared and analyzed statistically by ANOVA and Tukey's post-hoc test for significant differences (p=0.05). Based on the findings of this study, it may be concluded that regarding dentin removal from root canal walls during instrumentation, neither of the techniques can be considered more effective than the other. PMID:19031646

  7. Meta-analysis of the Prevalence of Helicobacter Pylori Infection among Children and Adults of Iran

    PubMed Central

    Moosazadeh, Mahmood; Lankarani, Kamran B.; Afshari, Mahdi

    2016-01-01

    Helicobacter pylori infection is a common health problem related to many gastrointestinal disorders. This study aims to estimate the total and age specific prevalence of Helicobacter Pylori infection in Iran. We systematically reviewed all national and international databases and finally identified 21 studies were eligible for meta-analysis. Each of them were assigned a quality score using STROBE checklist. Due to significant heterogeneity of the results, random effects model was used to estimate the pooled prevalence and 95% confidence interval of Helicobacter Pylori infection. All statistical analyses were performed using STATA. V11 software. The pooled prevalence (95% confidence interval) of Helicobacter Pylori infection among all population, children and adults were estimated as 54% (53%- 55%), 42% (41%- 44%) and 62% (61%- 64%) respectively. Helicobacter Pylori, has infected more than half of Iranian people during the last decade. Preventive strategies as well as taking into account this infection during clinical visits should be emphasized to reduce its transmission and prevalence within the community. PMID:27076886

  8. Efficiency of eugenol as anesthetic for the early life stages of Nile tilapia (Oreochromis niloticus).

    PubMed

    Ribeiro, Paula A P; Miranda-Filho, Kleber C; Melo, Daniela C de; Luz, Ronald K

    2015-03-01

    In aquaculture, activities with anesthetic compounds are usually used in order to ensure the welfare of farmed fish, allowing handling out of water with decreased trauma by stress. Presently, there is no information about anesthetic action of eugenol in early life stages of Nile tilapia (Oreochromis niloticus). The objective of this study was to evaluate different concentrations of eugenol for larvae and juveniles of Nile tilapia. Sixty animals were used for each group of weight, group I = 0.02 g; group II = 0.08 g; group III = 0.22 g; group IV = 2.62 g; and group V = 11.64 g. The eugenol concentrations tested were 50, 75, 100, 125, 150 and 175 mg L-1. No mortality was reported during the tests with eugenol. Tilapia larvae with 0.02 g and juveniles around 11.64 g can be anesthetized with eugenol concentrations between 150 and 175 mg L-1, since they determine the shortest sedation time (23 and 72 seconds, for the group of lowest and highest weights, respectively). PMID:25806995

  9. Identification and Application of Neutralizing Epitopes of Human Adenovirus Type 55 Hexon Protein

    PubMed Central

    Tian, Xingui; Ma, Qiang; Jiang, Zaixue; Huang, Junfeng; Liu, Qian; Lu, Xiaomei; Luo, Qingming; Zhou, Rong

    2015-01-01

    Human adenovirus type 55 (HAdV55) is a newly identified re-emergent acute respiratory disease (ARD) pathogen with a proposed recombination of hexon gene between HAdV11 and HAdV14 strains. The identification of the neutralizing epitopes is important for the surveillance and vaccine development against HAdV55 infection. In this study, four type-specific epitope peptides of HAdV55 hexon protein, A55R1 (residues 138 to 152), A55R2 (residues 179 to 187), A55R4 (residues 247 to 259) and A55R7 (residues 429 to 443), were predicted by multiple sequence alignment and homology modeling methods, and then confirmed with synthetic peptides by enzyme-linked immunosorbent assay (ELISA) and neutralization tests (NT). Finally, the A55R2 was incorporated into human adenoviruses 3 (HAdV3) and a chimeric adenovirus rAd3A55R2 was successfully obtained. The chimeric rAd3A55R2 could induce neutralizing antibodies against both HAdV3 and HAdV55. This current study will contribute to the development of novel adenovirus vaccine candidate and adenovirus structural analysis. PMID:26516903

  10. Spectrophotometric Standards for Cross-Observatory Calibration

    NASA Astrophysics Data System (ADS)

    Diaz-Miller, Rosa

    2005-07-01

    This program will obtain NICMOS spectrophotometry of four main sequence A stars and four K giants, each selected from the Spitzer IRAC photometric calibration target and/or candidate calibration target lists {Reach et al 2005, PASP,117,978}. These observations will supplement existing HST observations of DA white dwarfs and solar analogs, and will provide a broad base of stellar types for spectrophotometric cross calibration of HST, Spitzer, and eventually JWST. The targets are chosen to be faint enough for unsaturated observations with JWST NIRSPEC, yet still bright enough for high signal to noise in relatively short observations with HST+NICMOS and with Spitzer+IRAC.ANALYSIS OF THE FIRST OBS OF 1812095 & KF06T2These data demonstated heavy saturation in the longer exposures. For example, 1812095 {A3V, V=11.8, Ks=11.6} shows a peak rate of 250DN/s in G096, while KF06T2 {K1.5III V=13.8, Ks=11.3} reaches 250DN/s in G206, including the 100DN/s of background. Thus, full saturation of some charge wells occurred after integrating for 100s. Adopting a 2x safety factor, the integration times should be limited to 50s. The brightest stars are Ks=11, or 32% brighter.

  11. Supernova Remnants in the Sedov Expansion Phase: Thermal X-Ray Emission

    NASA Astrophysics Data System (ADS)

    Borkowski, Kazimierz J.; Lyerly, William J.; Reynolds, Stephen P.

    2001-02-01

    Improved calculations of X-ray spectra for supernova remnants (SNRs) in the Sedov-Taylor phase are reported, which for the first time include reliable atomic data for Fe L-shell lines. This new set of Sedov models also allows for a partial collisionless heating of electrons at the blast wave and for energy transfer from ions to electrons through Coulomb collisions. X-ray emission calculations are based on the updated Hamilton-Sarazin spectral model. The calculated X-ray spectra are successfully interpreted in terms of three distribution functions: the electron temperature and ionization timescale distributions, and the ionization timescale-averaged electron temperature distribution. The comparison of Sedov models with a frequently used single nonequilibrium ionization (NEI) timescale model reveals that this simple model is generally not an appropriate approximation to X-ray spectra of SNRs. We find instead that plane-parallel shocks provide a useful approximation to X-ray spectra of SNRs, particularly for young SNRs. Sedov X-ray models described here, together with simpler plane shock and single-ionization timescale models, have been implemented as standard models in the widely used XSPEC v11 spectral software package.

  12. Hardening of Ti-coated 4145 steel following boron ion implantation

    NASA Astrophysics Data System (ADS)

    Knystautas, Emile J.; Singh, Amatjit; Fiseti, Michel

    Mechanically polished 4145 steel surfaces coated with a 400 Å layer of titanium were studied for surface hardening following implantation with boron ions. The steel surfaces overlaid with a titanium coating were implanted with 110 keV 11B ions to a constant dose of 10 17 ions/cm 2. The microhardness of the titanium-coated specimens was compared with that of implanted but uncoated 4145 steel specimens. In both cases an increase in microhardness of some 20% for 10 g loads was observed. Annealing characteristics were determined by carefully annealing the titanium-coated specimens at different temperatures and times in a vacuum of less than 10 -6 Torr. The optimum annealing condition was found to be 200°C for 5 h, which yielded a 48% increase in microhardness for a 5 g load, while no significant increase was observed at 150°C. On the other hand, annealing at higher temperature (350°C) resulted in a decrease in the microhardness for all loads.

  13. Comparative serology techniques for the diagnosis of Trypanosoma cruzi infection in a rural population from the state of Querétaro, Mexico

    PubMed Central

    Villagrán-Herrera, María Elena; Sánchez-Moreno, Manuel; Rodríguez-Méndez, Adriana Jheny; Hernández-Montiel, Hebert Luis; Dávila-Esquivel, Felipe de Jesús; González-Pérez, Germán; Martínez-Ibarra, José Alejandro; de Diego-Cabrera, José Antonio

    2014-01-01

    Immunological diagnostic methods for Trypanosoma cruzi depend specifically on the presence of antibodies and parasitological methods lack sensitivity during the chronic and “indeterminate” stages of the disease. This study performed a serological survey of 1,033 subjects from 52 rural communities in 12 of the 18 municipalities in the state of Querétaro, Mexico. We detected anti-T. cruzi antibodies using the following tests: indirect haemagglutination assay (IHA), indirect immunofluorescence assay (IFA), ELISA and recombinant ELISA (rELISA). We also performed Western blot (WB) analysis using iron superoxide dismutase (FeSOD), a detoxifying enzyme excreted by the parasite, as the antigen. Positive test results were distributed as follows: ELISA 8%, rELISA 6.2%, IFA and IHA 5.4% in both cases and FeSOD 8%. A comparative study of the five tests was undertaken. Sensitivity levels, specificity, positive and negative predictive values, concordance percentage and kappa index were considered. Living with animals, trips to other communities, gender, age, type of housing and symptomatology at the time of the survey were statistically analysed using SPSS software v.11.5. Detection of the FeSOD enzyme that was secreted by the parasite and used as an antigenic fraction in WBs showed a 100% correlation with traditional ELISA tests. PMID:25411004

  14. Location of the 1979 April 6 gamma-ray burst

    SciTech Connect

    Laros, J.G.; Evans, W.D.; Fenimore, E.E.; Klebesadel, R.W.; Barat, C.; Hurley, K.; Niel, M.; Vedrenne, G.; Estulin, I.V.; Zenchenko, V.M.; Mersov, G.A.

    1981-04-15

    A gamma-ray burst was recorded on 1979 April 6 at 1140 UT by instruments on the Pioneer Venus Orbiter (PVO) Venera 11 (V11), Venera12 (V12), Prognoz 7 (P7), and International Sun-Earth Explorer-3 (ISEE-3) spacecraft. The event consisted of a single spike of 0.2 s duration and had a spectral feature near 400 keV (Mazets and Golenetskii), thus resembling the 1979 March 5 events (Mazets et al .; Cline et al .; Evans et al .; Brarat et al.) in two respects. However, important differences in rise time and spectral hardness prevent one from concluding positively that the two events shared the same mechanism or had comparable energetics. Using arrival time analysis we have obtained for the April 6 burst a <1/sub '/ diameter error box centered at (..cap alpha.., delta)/sub 1950/ = (23/sup h/11/sup m/12/sup s/,-49/sup 0/55'39''). According to our searches, there is no cataloged object within or suggestively close to this error box. A UK Schmidt plate of the region likewise revealed no images within the error box to m/sub v/ = 22.5. Constraints placed by these findings on the energetics and types of objects that could be responsible for the April 6 and possibly the March 5 bursts are discussed.

  15. A Three-Dimensional Study of Variations in Root Canal Morphology Using Cone-Beam Computed Tomography of Mandibular Premolars in a South Indian Population

    PubMed Central

    Hegde, Mithra N; Tahiliani, Divya; Shetty, Heeresh; Bhat, Ganesh T; Shetty, Shishir

    2014-01-01

    Background: Conventional radiographic techniques being two dimensional, has its restrictions and is confined to limited diagnostic value. However, the incorporation of Cone Beam Computed Tomography (CBCT) gives a three dimensional insight to the tooth morphology and leads to better evaluation and treatment management. Aim: The aim of this study was to evaluate and assess the root canal morphology of mandibular pre-molars in South Indian Population using CBCT radiographic technique. Materials and Methods: One thousand and eighty six and 814 fully erupted mandibular first and second premolars respectively were scanned using CBCT to evaluate the canal morphology according to Vertucci and Gulabiwala’s classification. Results: The most common configuration in mandibular first and second premolars was Vertucci’s Type I(83.81% and 93.48% respectively) followed by Type V (11.97% and 3.5% respectively). Conclusion: South Indian population presented Type IV ertucci’s canal morphology as the most common in mandibular first and second pre-molars followed by Type V. CBCT scanning poses a greater advantage in assessing the complexity of root canal morphology and planning an appropriate endodontic treatment for the same. PMID:25302261

  16. Solving the stellar 62Ni problem with AMS

    NASA Astrophysics Data System (ADS)

    Dillmann, I.; Faestermann, T.; Korschinek, G.; Lachner, J.; Maiti, M.; Poutivtsev, M.; Rugel, G.; Walter, S.; Käppeler, F.; Erhard, M.; Junghans, A. R.; Nair, C.; Schwengner, R.; Wagner, A.

    2010-04-01

    An accurate knowledge of the neutron capture cross sections of 62,63Ni is crucial since both isotopes take key positions which affect the whole reaction flow in the weak s process up to A≈90. No experimental value for the 63Ni(n,γ) cross section exists so far, and until recently the experimental values for 62Ni(n,γ) at stellar temperatures (kT=30keV) ranged between 12 and 37 mb. This latter discrepancy could now be solved by two activations with following AMS using the GAMS setup at the Munich tandem accelerator which are also in perfect agreement with a recent time-of-flight measurement. The resulting (preliminary) Maxwellian cross section at kT = 30 keV was determined to be <σ>=23.4±4.6mb. Additionally, we have measured the 64Ni(γ,n)63Ni cross section close to threshold. Photoactivations at 13.5 MeV, 11.4 MeV and 10.3 MeV were carried out with the ELBE accelerator at Forschungszentrum Dresden-Rossendorf. A first AMS measurement of the sample activated at 13.5 MeV revealed a cross section smaller by more than a factor of 2 compared to NON-SMOKER predictions.

  17. Linear Coherent Light Source, LCLS: The upgrade path

    NASA Astrophysics Data System (ADS)

    Bergmann, Uwe

    2014-03-01

    With ultrashort and ultrabright X-ray pulses (>1012 photons in pulses of < 100 femtosecond length) X-ray Free electron lasers provide revolutionary new capabilities to study a wide range of phenomena including novel states of matter, quantum materials, ultrafast chemistry and structural biology. Starting operations in 2009 the Linac Coherent Light Source (LCLS) at SLAC has been the first of such machines delivering 280 eV-11 keV X-ray pulses to users at a rate of 120 Hz. The success of the LCLS has positively impacted numerous efforts around the world and there are now five hard X-ray FELs in operation or under construction in addition to two FELs that operate in the VUV and soft X-ray region. The planned LCLS upgrade, LCLS-II, has recently been modified in order to address the recommendation of a report of the Basic Energy Science Advisory Committee from last summer. We will present examples of some of the most exciting LCLS science highlights, discuss operation upgrades and present the parameters of the new LCLS-II upgrade.

  18. A new species of Odorrana (Amphibia: Anura: Ranidae) from Vietnam.

    PubMed

    Pham, Cuong The; Nguyen, Truong Quang; Le, Minh Duc; Bonkowski, Michael; Ziegler, Thomas

    2016-01-01

    A new species of Odorrana is described from the karst forests in northeastern Vietnam based on morphological differences and molecular divergence. Morphologically, the new species is distinguishable from its congeners on the basis of a combination of the following diagnostic characters: (1) size large (SVL 85.9-91.6 mm in males, 108.7-110.1 mm in females); (2) head longer than wide; (3) vomerine teeth present; (4) external vocal sacs absent; (5) snout short (SL/SVL 0.16-0.17); (6) tympanum large (TD/ED 0.70 in males, 0.68 in females); (7) dorsal surface of head and anterior part of body smooth, posterior part of body and flanks with small tubercles; (8) supratympanic fold present; (9) dorsolateral fold absent; (10) webbing formula I0-0II0-0III0-1/2IV1/2-0V; (11) in life, dorsum green with dark brown spots; (12) flanks greyish brown with dark brown spots; (13) throat and chest grey, underside of limbs with large dark brown spots, edged in white, forming a network. In the phylogenetic analyses, the new species is unambiguously nested within the O. andersonii group, and placed as the sister taxon to O. wuchuanensis. PMID:27394273

  19. Characterization of nontransmural myocardial infarction by positron-emission tomography

    SciTech Connect

    Geltman, E.M.; Biello, D.; Welch, M.J.; Ter-Pogossian, M.M.; Roberts, R.; Sobel, B.E.

    1982-04-01

    The present study was performed to determine whether positron emission tomography (PET) performed after i.v. 11C-palmitate permits detection and characterization of nontransmural myocardial infarction. PET was performed after the i.v. injection of 11C-palmitate in 10 normal subjects, 24 patients with initial nontransmural myocardial infarction (defined electrocardiographically), and 22 patients with transmural infarction. Depressed accumulation of 11C-palmitate was detected with sagittal, coronal and transverse reconstructions, and quantified based on 14 contiguous transaxial reconstructions. Defects with homogeneously intense depression of accumulation of tracer were detected in all 22 patients with transmural infarction (100%). Abnormalities of the distribution of 11C-palmitate in the myocardium were detected in 23 patients with nontransmural infarction (96%). Thallium scintigrams were abnormal in only 11 of 18 patients with nontransmural infarction (61%). Tomographically estimated infarct size was greater among patients with transmural infarction (50.4 +/- 7.8 PET-g-Eq/m2 (+/- SEM SEM)) compared with those with nontransmural infarction (19 +/- 4 PET-g-Eq, p less than 0.01). Residual accumulation of 11C-palmitate within regions of infarction was more intensely depressed among patients with transmural compared to nontransmural infarction (33 +/- 1 vs 39 +/- 1% maximal myocardial radioactivity, p less than 0.01). Thus, PET and metabolic imaging with 11C-palmitate is a sensitive means of detecting, quantifying and characterizing nontransmural and transmural myocardial infarction.

  20. Norman L. Bowen Award to John Barry Dawson

    NASA Astrophysics Data System (ADS)

    Smith, Joseph V.; Dawson, J. B.

    Barry Dawson is just right for th e first Norman L. Bowen Award in Volcanology, Geochemistry, and Petrology. Like Norman L. Bowen, he has the inspiration to combine ideas from different disciplines to obtain a higher synthesis. Consider his brilliant talk of yesterday morning (Eos 69, p. 502, abstract V11C-06, Veined and metasomatised upper mantle beneath the Eastern African Rift: Evidence from N. Tanzania xenoliths). Barry rapidly reviewed the tectonic setting of east Africa, showed some nice photographs of the volcanic cones of Pello and Oldoinyo Lengai, focused on the upper-mantle xenoliths in scoria at Pello, moved in on the microscopy and mineral chemistry of the metasomatic veins in the peridotites, snowed how the lower density of a metasomatized peridotite would fit the middle of a geophysical profile from seismic surveys, and brought off a grand finale in which the Kenya dome was interpreted to result from inflation related to metasomatization of underlying peridotite. Undoubtedly, this will lead to many further studies of doming adjacent to rift systems around the world.

  1. The Importance of Caveolin-1 as Key-Regulator of Three-Dimensional Growth in Thyroid Cancer Cells Cultured under Real and Simulated Microgravity Conditions.

    PubMed

    Riwaldt, Stefan; Bauer, Johann; Pietsch, Jessica; Braun, Markus; Segerer, Jürgen; Schwarzwälder, Achim; Corydon, Thomas J; Infanger, Manfred; Grimm, Daniela

    2015-01-01

    We recently demonstrated that the CAV1 gene was down-regulated, when poorly differentiated thyroid FTC-133 cancer cells formed spheroids under simulated microgravity conditions. Here, we present evidence that the caveolin-1 protein is involved in the inhibition of spheroid formation, when confluent monolayers are exposed to microgravity. The evidence is based on proteins detected in cells and their supernatants of the recent spaceflight experiment: "NanoRacks-CellBox-Thyroid Cancer". The culture supernatant had been collected in a special container adjacent to the flight hardware incubation chamber and stored at low temperature until it was analyzed by Multi-Analyte Profiling (MAP) technology, while the cells remaining in the incubation chamber were fixed by RNAlater and examined by mass spectrometry. The soluble proteins identified by MAP were investigated in regard to their mutual interactions and their influence on proteins, which were associated with the cells secreting the soluble proteins and had been identified in a preceding study. A Pathway Studio v.11 analysis of the soluble and cell-associated proteins together with protein kinase C alpha (PRKCA) suggests that caveolin-1 is involved, when plasminogen enriched in the extracellular space is not activated and the vascular cellular adhesion molecule (VCAM-1) mediated cell-cell adhesion is simultaneously strengthened and activated PRKCA is recruited in caveolae, while the thyroid cancer cells do not form spheroids. PMID:26633361

  2. Long-term safety evaluation of bimatoprost ophthalmic solution 0.03%: a pooled analysis of six double-masked, randomized, active-controlled clinical trials

    PubMed Central

    Wirta, David; VanDenburgh, Amanda M; Weng, Emily; Whitcup, Scott M; Kurstjens, Sef; Beddingfield, Frederick C

    2011-01-01

    Background: Bimatoprost ophthalmic solution 0.03% was approved in the US for reducing intraoccular pressure (IOP) based on two double-masked, active-controlled clinical trials. Four additional long-term studies (≥12 months) were conducted; however, the aggregate safety profile of the six studies has not been reported. Methods: Adverse events (AEs) were pooled from six double-masked, active-controlled, long-term clinical trials in which subjects received bimatoprost 0.03% once daily (QD) or twice daily (BID) as an eyedrop. AE terms were converted to MedDRA (V.11.0) Preferred Terms and analyzed. Results: In total, 1409 patients received more than one dose of bimatoprost 0.03% QD or BID. Most AEs were mild in severity and reported by 86.7% (QD) and 94.8% (BID) of subjects (≤12 months of treatment). AEs reported through month 12 (aggregate incidence of ≥5%) were conjunctival hyperemia, increased eyelash growth, eye pruritus, periocular skin hyperpigmentation, eye irritation, dry eye, and hypertrichosis. AE onset was generally reported within four months of treatment. The cumulative incidence of common AEs in the QD treatment group at 24–48 months was similar to that measured at 12 months of treatment. Conclusion: Bimatoprost 0.03% has a favorable safety and tolerability profile as characterized by six long-term studies. Common AEs were due to the known pharmacological activity of bimatoprost and reversible with treatment cessation. PMID:21691584

  3. VizieR Online Data Catalog: AAVSO Photometric All Sky Survey (APASS) DR9 (Henden+, 2016)

    NASA Astrophysics Data System (ADS)

    Henden, A. A.; Templeton, M.; Terrell, D.; Smith, T. C.; Levine, S.; Welch, D.

    2016-01-01

    The AAVSO Photometric All Sky Survey (APASS) project is designed to bridge the gap between the shallow Tycho2 two-bandpass photometric catalog that is complete to V=11 and the deeper, but less spatially-complete catalogs like SDSS or PanSTARRS. It can be used for calibration of a specific field; for obtaining spectral information about single sources, determining reddening in a small area of the sky; or even obtaining current-epoch astrometry for rapidly moving objects. The survey is being performed at two locations: near Weed, New Mexico in the Northern Hemisphere; and at CTIO in the Southern Hemisphere. Each site consists of dual bore-sighted 20cm telescopes on a single mount, designed to obtain two bandpasses of information simultaneously. Each telescope covers 9 square degrees of sky with 2.5arcsec pixels, with the main survey taken with B,V,g',r',i' filters and covering the magnitude range 10

  4. Aloe vera Aqueous Extract Effect on Morphine Withdrawal Syndrome in Morphine-Dependent Female Rats

    PubMed Central

    Shahraki, Mohammad Reza; Mirshekari, Hamideh; Sabri, Azame

    2014-01-01

    Background: Aloe vera is a medicinal herb used as an anti-inflammatory and sedative agent. Objectives: The current study aimed to evaluate the effect of Aloe vera aqueous extract on morphine withdrawal symptoms in morphine-dependent female rats. Patients and Methods: The current research was performed on 40 female Wista-Albino rats which were made dependent on morphine using Houshyar protocol and were randomly divided into five groups (A, B, C, D, and E). Group A did not receive any agent in the period of handling but other groups (B, C, D and E) received 5, 10, 20 and 40 mg/kg of Aloe vera aqueous extract by gavage, three times daily for a week, respectively. Withdrawal symptoms, stool form, agitation, disparity, floppy eyelids, and body mass variations were checked for 10 days. The obtained data were analyzed using SPSS v.11 software, and Friedman, Kruskal-Wallis, and Mann-Whitney statistical tests. Statistical difference was considered significant (P < 0.05). Results: The results of the present study showed that agitation, disparity, and floppy eyelids in group E were significantly higher than those of others groups; however, these symptoms in group C were significantly lower than those of the other groups. Conclusions: The results of the present study revealed that the Aloe vera aqueous extract had various effects on morphine withdrawal syndrome in morphine-dependent female rats . PMID:25593890

  5. Assessment of occupational exposure to inorganic arsenic based on urinary concentrations and speciation of arsenic.

    PubMed

    Farmer, J G; Johnson, L R

    1990-05-01

    An analytical speciation method, capable of separating inorganic arsenic (As (V), As (III] and its methylated metabolites (MMAA, DMAA) from common, inert, dietary organoarsenicals, was applied to the determination of arsenic in urine from a variety of workers occupationally exposed to inorganic arsenic compounds. Mean urinary arsenic (As (V) + As (III) + MMAA + DMAA) concentrations ranged from 4.4 micrograms/g creatinine for controls to less than 10 micrograms/g for those in the electronics industry, 47.9 micrograms/g for timber treatment workers applying arsenical wood preservatives, 79.4 micrograms/g for a group of glassworkers using arsenic trioxide, and 245 micrograms/g for chemical workers engaged in manufacturing and handling inorganic arsenicals. The maximum recorded concentration was 956 micrograms/g. For the most exposed groups, the ranges in the average urinary arsenic speciation pattern were 1-6% As (V), 11-14% As (III), 14-18% MMAA, and 63-70% DMAA. The highly raised urinary arsenic concentrations for the chemical workers, in particular, and some glassworkers are shown to correspond to possible atmospheric concentrations in the workplace and intakes in excess of, or close to, recommended and statutory limits and those associated with inorganic arsenic related diseases. PMID:2357455

  6. Assessment of occupational exposure to inorganic arsenic based on urinary concentrations and speciation of arsenic.

    PubMed Central

    Farmer, J G; Johnson, L R

    1990-01-01

    An analytical speciation method, capable of separating inorganic arsenic (As (V), As (III] and its methylated metabolites (MMAA, DMAA) from common, inert, dietary organoarsenicals, was applied to the determination of arsenic in urine from a variety of workers occupationally exposed to inorganic arsenic compounds. Mean urinary arsenic (As (V) + As (III) + MMAA + DMAA) concentrations ranged from 4.4 micrograms/g creatinine for controls to less than 10 micrograms/g for those in the electronics industry, 47.9 micrograms/g for timber treatment workers applying arsenical wood preservatives, 79.4 micrograms/g for a group of glassworkers using arsenic trioxide, and 245 micrograms/g for chemical workers engaged in manufacturing and handling inorganic arsenicals. The maximum recorded concentration was 956 micrograms/g. For the most exposed groups, the ranges in the average urinary arsenic speciation pattern were 1-6% As (V), 11-14% As (III), 14-18% MMAA, and 63-70% DMAA. The highly raised urinary arsenic concentrations for the chemical workers, in particular, and some glassworkers are shown to correspond to possible atmospheric concentrations in the workplace and intakes in excess of, or close to, recommended and statutory limits and those associated with inorganic arsenic related diseases. PMID:2357455

  7. Reaction engineering studies for the production of 2-hydroxyisobutyric acid with recombinant Cupriavidus necator H 16.

    PubMed

    Hoefel, Torben; Wittmann, Eva; Reinecke, Liv; Weuster-Botz, Dirk

    2010-09-01

    Recombinant Cupriavidus necator H 16 with a novel metabolic pathway using a cobalamin-dependent mutase was exploited to produce 2-hydroxyisobutyric acid (2-HIBA) from renewable resources through microbial fermentation. 2-HIBA production capacities of different strains of C. necator H 16 deficient in the PHB synthase gene and genetically engineered to enable the production of 2-HIBA from the intracellular PHB precursor (R)-3-hydroxybutyryl-CoA were evaluated in 48 parallel milliliter-scale stirred tank bioreactors (V = 11 mL). The effects of media composition, limitations, pH, and feed rate were studied with respect to the overall process performances of the different recombinant strains. 2-HIBA production was at a maximum at nitrogen limiting conditions and if the pH was controlled between 6.8 and 7.2 under fed-batch operating conditions (intermittent fructose addition). The final concentration of 2-HIBA was 7.4 g L(-1) on a milliliter scale. Best reaction conditions identified on the milliliter scale were transferred to a laboratory-scale fed-batch process in a stirred tank bioreactor (V = 2 L). Two different process modes for the production of 2-HIBA, a single-phase and a dual-phase fermentation procedure, were evaluated and compared on a liter scale. The final concentration of 2-HIBA was 6.4 g L(-1) on a liter scale after 2 days of cultivation. PMID:20625719

  8. PAPR mitigation algorithms for OFDM WiMAX link

    NASA Astrophysics Data System (ADS)

    Rashwan, Gasem; Kenshil, Salih; Matin, Mohammad

    2013-09-01

    OFDM has been adopted in many high systems due to its high data rates and to its robust performance in fading channel. OFDM distributes the data among number of carriers which are called subcarriers. The subcarriers must be orthogonal to prevent the carrier from interfering to each other. Features such overcoming ISI (inter-symbol interference) and the complexity of Designing both receiver and transmitter made it ideal technique for both wired and wireless communication as long as optical communications. However, OFDM suffers from a defect called Peak Average power ratio (PAPR). APARP is crucial drawback that limits the way that OFDM functions and reducing or mitigating this factor in wireless and optical environment will help overcome and enhance the OFDM date rate. PAPR is the main cause of inter-carrier interference and high out-of-band power, and consequently Bit error rate BER. We investigate some of the techniques that mitigate the effect of PAPR. These techniques are merged together to provide a better PAPR reduction with the existing techniques. In this paper, we are proposing a new reduction algorithm to minimize the effect of the PAPR. The results and simulation are done in Optisystem V-11 and Matlab environment. These approaches will be applied on WiMAX application and the performances between the different techniques are examined.

  9. [A new human machine interface in neurosurgery: The Leap Motion(®). Technical note regarding a new touchless interface].

    PubMed

    Di Tommaso, L; Aubry, S; Godard, J; Katranji, H; Pauchot, J

    2016-06-01

    Currently, cross-sectional imaging viewing is used in routine practice whereas the surgical procedure requires physical contact with an interface (mouse or touch-sensitive screen). This type of contact results in a risk of lack of aseptic control and causes loss of time. The recent appearance of devices such as the Leap Motion(®) (Leap Motion society, San Francisco, USA) a sensor which enables to interact with the computer without any physical contact is of major interest in the field of surgery. However, its configuration and ergonomics produce key challenges in order to adapt to the practitioner's requirements, the imaging software as well as the surgical environment. This article aims to suggest an easy configuration of the Leap Motion(®) in neurosurgery on a PC for an optimized utilization with Carestream(®) Vue PACS v11.3.4 (Carestream Health, Inc., Rochester, USA) using a plug-in (to download at: https://drive.google.com/?usp=chrome_app#folders/0B_F4eBeBQc3ybElEeEhqME5DQkU) and a video tutorial (https://www.youtube.com/watch?v=yVPTgxg-SIk). PMID:27234915

  10. Leap Motion Gesture Control With Carestream Software in the Operating Room to Control Imaging: Installation Guide and Discussion.

    PubMed

    Pauchot, Julien; Di Tommaso, Laetitia; Lounis, Ahmed; Benassarou, Mourad; Mathieu, Pierre; Bernot, Dominique; Aubry, Sébastien

    2015-12-01

    Nowadays, routine cross-sectional imaging viewing during a surgical procedure requires physical contact with an interface (mouse or touch-sensitive screen). Such contact risks exposure to aseptic conditions and causes loss of time. Devices such as the recently introduced Leap Motion (Leap Motion Society, San Francisco, CA), which enables interaction with the computer without any physical contact, are of wide interest in the field of surgery, but configuration and ergonomics are key challenges for the practitioner, imaging software, and surgical environment. This article aims to suggest an easy configuration of Leap Motion on a PC for optimized use with Carestream Vue PACS v11.3.4 (Carestream Health, Inc, Rochester, NY) using a plug-in (to download at https://drive.google.com/open?id=0B_F4eBeBQc3yNENvTXlnY09qS00&authuser=0) and a video tutorial (https://www.youtube.com/watch?v=yVPTgxg-SIk). Videos of surgical procedure and discussion about innovative gesture control technology and its various configurations are provided in this article. PMID:26002115

  11. Low Reynolds turbulence model CFD simulation for complex electronic system: an industrial point of view

    NASA Astrophysics Data System (ADS)

    Giannuzzi, M.

    2014-07-01

    In electronic systems the presence of bluff bodies, sharp corners and bends are the cause of flow separation and large recirculation bubbles. Since the recirculation vortices develop they encapsulate the heat from an electronic component becoming one of the major contributors of malfunction. Going in depth in this, some numerical simulations of conjugate heat transfer for a heat wall-mounted cube have been performed using the commercial CFD code scSTREAM V11 by Software Cradle Co, Ltd. It is well known that the reliability of CFD analysis depends heavily on the turbulent model employed together with the wall functions implemented. The three low- Reynolds k - epsilon turbulent models developed by Abe-Nagano-Kondoh have been validated against experimental data consisting mainly of velocity profiles and surface temperature distributions provided in literature. The performed validation shows a satisfactory agreement between the measured and simulated data. The turbulent model chosen is then used for the CFD simulation of a complex electronic system.

  12. The use of β titanium alloys in the aerospace industry

    NASA Astrophysics Data System (ADS)

    Boyer, R. R.; Briggs, R. D.

    2005-12-01

    Beta titanium alloys have been available since the 1950s (Ti-13V-11Cr-3Mo or B120VCA), but significant applications of these alloys, beyond the SR-71 Blackbird, have been slow in coming. The next significant usage of a β alloy did not occur until the mid-1980s on the B-1B bomber. This aircraft used Ti-15V-3Cr-3Al-3Sn sheet due to its capability for strip rolling, improved formability, and higher strength than Ti-6Al-4V. The next major usage was on a commercial aircraft, the Boeing 777, which made extensive use of Ti-10V-2Fe-3Al high-strength forgings. Ti-15V-3Cr-3Al-3Sn environmental control system ducting, castings, and springs were also used, along with Ti-3Al-8V-6Cr-4Mo-4Zr (β-C) springs. Beta-21S was also introduced for high-temperature usage. More recent work at Boeing has focused on the development of Ti-5Al-5Mo-5V-3Cr, a high-strength alloy that can be used at higher strength than Ti-10V-2Fe-3Al and is much more robust; it has a much wider, or friendlier, processing window. This, along with additional studies at Boeing, and from within the aerospace industry in general will be discussed in detail, summarizing applications and the rationale for the selection of this alloy system for aerospace applications.

  13. SuperWASP discovery and SALT confirmation of a semi-detached eclipsing binary that contains a δ Scuti star

    NASA Astrophysics Data System (ADS)

    Norton, A. J.; Lohr, M. E.; Smalley, B.; Wheatley, P. J.; West, R. G.

    2016-03-01

    Aims: We searched the SuperWASP archive for objects that display multiply periodic photometric variations. Methods: Specifically we sought evidence for eclipsing binary stars that display a further non-harmonically related signal in their power spectra. Results: The object 1SWASP J050634.16-353648.4 has been identified as a relatively bright (V ~ 11.5) semi-detached eclipsing binary with a 5.104 d orbital period that displays coherent pulsations with a semi-amplitude of 65 mmag at a frequency of 13.45 d-1. Follow-up radial velocity spectroscopy with the Southern African Large Telescope confirmed the binary nature of the system. Using the phoebe code to model the radial velocity curve with the SuperWASP photometry enabled parameters of both stellar components to be determined. This yielded a primary (pulsating) star with a mass of 1.73 ± 0.11 M⊙ and a radius of 2.41 ± 0.06 R⊙, as well as a Roche-lobe filling secondary star with a mass of 0.41 ± 0.03 M⊙ and a radius of 4.21 ± 0.11 R⊙. Conclusions: 1SWASP J050634.16-353648.4 is therefore a bright δ Sct pulsator in a semi-detached eclipsing binary with one of the largest pulsation amplitudes of any such system known. The pulsation constant indicates that the mode is likely a first overtone radial pulsation.

  14. Efficient quasi-monoenergetic ion beams up to 18 MeV/nucleon via self-generated plasma fields in relativistic laser plasmas

    NASA Astrophysics Data System (ADS)

    Palaniyappan, Sasi; Huang, Chengkun; Gautier, Donald; Hamilton, Christopher; Santiago, Miguel; Kreuzer, Christian; Shah, Rahul; Fernandez, Juan; Los Alamos National Laboratory Team; Ludwig-Maximilian-University Team

    2015-11-01

    Table-top laser-plasma ion accelerators seldom achieve narrow energy spreads, and never without serious compromises in efficiency, particle yield, etc. Using massive computer simulations, we identify a self-organizing scheme that exploits persisting self-generated plasma electric (~ TV/m) and magnetic (~ 104 Tesla) fields to reduce the ion energy spread after the laser exits the plasma - separating the ion acceleration from the energy spread reduction. Consistent with the scheme, we experimentally demonstrate aluminum and carbon ion beams with narrow spectral peaks at energies up to 310 MeV (11.5 MeV/nucleon) and 220 MeV (18.3 MeV/nucleon), respectively, with high conversion efficiency (~ 5%, i.e., 4J out of 80J laser). This is achieved with 0.12 PW high-contrast Gaussian laser pulses irradiating planar foils with optimal thicknesses of up to 250 nm that scale with laser intensity. When increasing the focused laser intensity fourfold (by reducing the focusing optic f/number twofold), the spectral-peak energy increases twofold. These results pave the way for next generation compact accelerators suitable for applications. For example, 400 MeV (33.3 MeV/nucleon) carbon-ion beam with narrow energy spread required for ion fast ignition could be generated using PW-class lasers.

  15. In-vitro antioxidant and antibacterial activities of Xanthium strumarium L. extracts on methicillin-susceptible and methicillin-resistant Staphylococcus aureus

    PubMed Central

    Rad, Javad Sharifi; Alfatemi, Seyedeh Mahsan Hoseini; Rad, Majid Sharifi; Iriti, Marcello

    2013-01-01

    Background and Aims: The excessive and repeated use of antibiotics in medicine has led to the development of antibiotic-resistant microbial strains, including Staphylococcus aureus whose emergence of antibiotic-resistant strains has reduced the number of antibiotics available to treat clinical infections caused by this bacterium. In this study, antioxidant and antimicrobial activities of methanolic extract of Xanthium strumarium L. leaves were evaluated on methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MRSA) spp. Materials and Methods: Antiradical and antioxidant activities X. strumarium L. leaf extract were evaluated based on its ability to scavenge the synthetic 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and by the paired diene method, respectively, whereas the antimicrobial activity was assayed by the disc diffusion method. Statistical Analysis: Data were subjected to analysis of variance following an entirely random design to determine the least significant difference at P < 0.05 using SPSS v. 11.5. Results and Conclusions: The IC50 values of the extract were 0.02 mg/mL and 0.09 mg/mL for the antioxidant and DPPH-scavenging capacity, respectively. X. strumarium extract affected both methicillin-sensitive Staphylococcus aureus and MRSA, though antibacterial activity was more effective on methicillin-susceptible S. aureus spp. The antibacterial and antioxidant activities exhibited by the methanol extract may justify the traditional use of this plant as a folk remedy worldwide. PMID:25284944

  16. Mapping of the viral mRNA encoding a super-T antigen of 115,000 daltons expressed in simian virus 40-transformed rat cell lines.

    PubMed Central

    May, E; Kress, M; Daya-Grosjean, L; Monier, R; May, P

    1981-01-01

    Simian virus 40-transformed V11 F1 clone 1 subclone 7 rat cells produced a considerable amount of an elongated form of large-T antigen with an Mr of 115,000 (115K super-T antigen), but these cells did not produce detectable traces of normal-sized large-T antigen (86,000 daltons) (P. May, M. Kress, M. Lange, and E. May, Cold Spring Harbor Symp. Quant. Biol. 44:189-200, 1980). First, a comparison of the tryptic peptide fingerprints of 115K super-T and large-T antigens suggested that 115K super-T antigen is simian virus 40 coded and contains a duplication of amino acid sequences of large-T antigen. Second, from S1 mapping analysis of 115K super-T mRNA, performed with various restriction fragments of simian virus 40 DNA, it was concluded that super-T mRNA is a form of large-T mRNA containing a tandem duplication of the sequence extending from approximately 0.46 to 0.35 map unit. The duplicated sequence corresponded to that region of the simian virus 40 genome in which 12 of 13 tsA mutation sites are clustered (C. J. Lai and D. Nathans, Virology 66:70-81, 1975). Images PMID:6260978

  17. Serum Samples From Middle-aged Adults Vaccinated Annually with Seasonal Influenza Vaccines Cross-neutralize Some Potential Pandemic Influenza Viruses.

    PubMed

    Wang, Wei; Alvarado-Facundo, Esmeralda; Chen, Qiong; Anderson, Christine M; Scott, Dorothy; Vassell, Russell; Weiss, Carol D

    2016-02-01

    We examined serum samples from adults ages 48-64 who received multiple seasonal influenza vaccines from 2004 to 2009 for cross-neutralizing antibodies to potential pandemic strains. Using pseudoviruses bearing various hemagglutinins (HA-pseudoviruses), we found serum neutralization titers (≥160) in 100% against A/Japan/305/1957 (H2N2), 53% against A/Hong Kong/1073/99 (H9N2), 56% against the H3N2 variant A/Indiana/08/11 (H3N2v), 11% against A/Hong Kong/G9/97 (H9N2), and 36% A/chicken/Hong Kong/SF4/01 (H6N1). None had titers >160 to A/Shanghai/2/13 (H7N9) or A/Netherlands/219/03 (H7N7). Thirty-six percent to 0% had neutralization titers to various H5N1 strains. Titers to H9, H6, and H5 HA-pseudoviruses correlated with each other, but not with H3N2v, suggesting group-specific cross-neutralization. PMID:26243315

  18. The PLATO 2.0 mission. Spanish contribution

    NASA Astrophysics Data System (ADS)

    Mas-Hesse, J. M.; Urqui O'Callaghan, R.; Suárez J. C.; Deeg, H.; Balado, A.

    2015-05-01

    The PLATO 2.0 space mission (PLAnetary Transits and Oscillation of stars) was selected by the ESA Science Programme in February 2014, as the M3 mission to be launched in 2024. PLATO 2.0 will detect terrestrial exoplanets in the habitable zone of bright solar-type stars and characterise their bulk properties. The exoplanets will be detected by the weak eclipses they produce when transiting in front of their parent star, while the long uninterrupted observations will allow also to analyze the oscillations of these stars, yielding their internal structure and evolutionary state. The stellar sample targeted by PLATO is bright enough (V<11.5) to be able to confirm the planets candidates using radial velocity spectroscopy from ground, providing so a complete characterization of the exoplanetary systems. Spain will contribute to the PLATO 2.0 instrument by providing the Focal Plane Assemblies of its 34 telescopes, as well as the Main Electronics Units which will perform onboard and in real time the photometric extraction of the stellar lightcurves.

  19. Relative susceptibility of titanium alloys to hot-salt stress-corrosion

    NASA Technical Reports Server (NTRS)

    Gray, H. R.

    1971-01-01

    Susceptibility of titanium alloys to hot-salt stress-corrosion cracking increased as follows: Ti-2Al-11Sn-5Zr-0.2Si(679), Ti-6Al-2Sn-4Zr-2Mo(6242), Ti-6Al-4V(64), Ti-6Al-4V-3Co(643), Ti-8Al-1Mo-1V(811), and Ti-13V-11Cr-3A1(13-11-3). The Ti-5Al-6Sn-2Zr-1Mo-0.25Si(5621S) alloy was both the least and most susceptible depending on heat treatment. Such rankings can be drastically altered by heat-to-heat and processing variations. Residual compressive stresses and cyclic exposures also reduce susceptibility to stress-corrosion. Simulated turbine-engine compressor environmental variables such as air velocity, pressure, dewpoint, salt concentration, and salt deposition temperature have only minor effects. Detection of substantial concentrations of hydrogen in all corroded alloys confirmed the existence of a hydrogen embrittlement mechanism.

  20. Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression.

    PubMed

    Taranu, Ionelia; Braicu, Cornelia; Marin, Daniela Eliza; Pistol, Gina Cecilia; Motiu, Monica; Balacescu, Loredana; Beridan Neagoe, Ioana; Burlacu, Radu

    2015-01-01

    The gut represents the main route of intoxication with mycotoxins. To evaluate the effect and the underlying molecular changes that occurred when the intestine is exposed to zearalenone, a Fusarium sp mycotoxin, porcine epithelial cells (IPEC-1) were treated with 10μM of ZEA for 24h and analysed by microarray using Gene Spring GX v.11.5. Our results showed that 10μM of ZEA did not affect cell viability, but can increase the expression of toll like receptors (TLR1-10) and of certain cytokines involved in inflammation (TNF-α, IL-1β, IL-6, IL-8, MCP-1, IL-12p40, CCL20) or responsible for the recruitment of immune cells (IL-10, IL-18). Microarray results identified 190 genes significantly and differentially expressed, of which 70% were up-regulated. ZEA determined the over expression of ITGB5 gene, essential against the attachment and adhesion of ETEC to porcine jejunal cells and of TFF2 implicated in mucosal protection. An up-regulation of glutathione peroxidase enzymes (GPx6, GPx2, GPx1) was also observed. Upon ZEA challenge, genes like GTF3C4 responsible for the recruitment of polymerase III and initiation of tRNA transcription in eukaryotes and STAT5B were significantly higher induced. The up-regulation of CD97 gene and the down-regulation of tumour suppressor genes (DKK-1, PCDH11X and TC531386) demonstrates the carcinogenic potential of ZEA. PMID:25455459

  1. Investigation of the relationship between carrying school bags (handbags and backpacks) and the prevalence of musculoskeletal pains among 12-15 year old students in Shiraz.

    PubMed

    Arghavani, Farshad; Zamanian, Zahra; Ghanbary, Ali; Hassanzadeh, Jafar

    2014-04-01

    Inappropriate school bags put students at risk of musculoskeletal problems and early fatigue. Heavy bags can change the body posture and the musculoskeletal system must react appropriately in order to compensate for this stress. It is recommended that the weight of a school bag must not be more than 10% of the student's body weight and the weight must be placed on both shoulders. The present study aimed to identify the risk factors associated with musculoskeletal disorders by comparing the prevalence of musculoskeletal pains among the students. The present descriptive, cross-sectional study was conducted in different educational districts of Shiraz. The study samples were selected using cluster sampling method. In this study, 800 students marked their painful areas on body maps and the SPSS statistical software (v. 11.5) was used to analyze the data. The results showed that among the students who used backpacks, 48.9% carried the weight on both shoulders, 40.4% carried the weight on their right shoulders, and 10.6% used their left shoulders. Besides, 68.02% of the students carrying handbags often used their right shoulders, while 31.98% used their left shoulders. The study results showed that similar to other countries, Iranian students also mostly made use of backpacks. Moreover, the musculoskeletal pains were most prevalent in the shoulders, which is in line with many other studies conducted on the issue. PMID:25911845

  2. Relaxation of H/sub 2/ vibrational motion by wall collisions

    SciTech Connect

    Karo, A.M.; DeBoni, T.M.; Hiskes, J.R.

    1980-01-01

    The method of computer molecular dynamics was applied to an important technological problem where experimental data may be extremely difficult to obtain: collisional de-excitation at surfaces of vibrationally highly excited hydrogen molecules. The calculations have been carried out primarily for vibrational states about the v = 6 level. The technique is illustrated by means of a specific example and the detail that can be obtained from such calculations concerning the dynamics of the interaction is shown. Molecular states excited to the v = 4, v = 6, and v = 11 vibrational levels and the J = 1 rotational level have been examined. The translational temperature of the molecules is chosen to be 500/sup 0/K, and the wall is given thermal motion characteristic of a temperature of 500/sup 0/K. Different angles of approach have been studied, and different impact points on the surface have been selected. After the first collision, the impact point becomes random because of the stochastic nature of subsequent molecular trajectories. For any given collision with the wall, the molecule may pick up or lose vibrational, rotational, and translational energy. Careful sampling and averaging of the results of many trajectory runs is needed in order to arrive at meaningful conclusions about the probability of de-excitation as a function of such parameters as the number of wall collisions, the residence time, the wall temperature, and the microscopic nature of the wall itself.

  3. Higher Efficiency for Quasi-Solid State Dye Sensitized Solar Cells Under Low Light Irradiance

    NASA Astrophysics Data System (ADS)

    Desilva, Ajith; Bandara, T. M. W. J.; Fernado, H. D. N. S.; Fernando, P. S. L.; Dissanayake, M. A. K. L.; Jayasundara, W. J. M. J. S. R.; Furlani, M.; Mellander, B.-E.

    2014-03-01

    Dye-sensitized solar cells (DSSCs), lower cost solar energy conversion devices are alternative green energy source. The liquid based electrolyte DSSCs have higher efficiencies with many practical issues while the quasi-solid-state DSSCs resolve the key problems but efficiencies are relatively low. Polyacrylonitrile (PAN) based gel polymer electrolytes were fabricated as DSSCs by incorporating ethylene carbonate and propylene carbonate plasticizers and tetrapropylammonium iodide salt. A thin layer of electrolyte was sandwiched between the TiO2 anode (sensitized with N719 dye) and the Pt counter electrode. The electrolyte had an ionic conductivity of 2.6 mS/cm at 25 degrees of Celsius. DSSCs incorporating this gel electrolyte revealed Vsc circuit, Jsc, fill factor (FF) and efficiency values of 0.71 V, 11.8 mA, 51 percent and 4.2 percent respectively under 1 sun irradiation. The efficiency of the cell increased with decreasing solar irradiance achieving up to 10 percent efficiency and 80 percent FF at low irradiance values. This work uncovers that quasi-solid state DSSCs can reach efficiencies close to that of liquid electrolytes based cells.

  4. Development and implementation of a portable grating interferometer system as a standard tool for testing optics at the Advanced Photon Source beamline 1-BM.

    PubMed

    Assoufid, Lahsen; Shi, Xianbo; Marathe, Shashidhara; Benda, Erika; Wojcik, Michael J; Lang, Keenan; Xu, Ruqing; Liu, Wenjun; Macrander, Albert T; Tischler, Jon Z

    2016-05-01

    We developed a portable X-ray grating interferometer setup as a standard tool for testing optics at the Advanced Photon Source (APS) beamline 1-BM. The interferometer can be operated in phase-stepping, Moiré, or single-grating harmonic imaging mode with 1-D or 2-D gratings. All of the interferometer motions are motorized; hence, it is much easier and quicker to switch between the different modes of operation. A novel aspect of this new instrument is its designed portability. While the setup is designed to be primarily used as a standard tool for testing optics at 1-BM, it could be potentially deployed at other APS beamlines for beam coherence and wavefront characterization or imaging. The design of the interferometer system is described in detail and coherence measurements obtained at the APS 34-ID-E beamline are presented. The coherence was probed in two directions using a 2-D checkerboard, a linear, and a circular grating at X-ray energies of 8 keV, 11 keV, and 18 keV. PMID:27250384

  5. Human papillomavirus and breast cancer in Iran: a meta- analysis

    PubMed Central

    Haghshenas, Mohammad Reza; Mousavi, Tahoora; Moosazadeh, Mahmood; Afshari, Mahdi

    2016-01-01

    Objective(s): This study aims to investigate the relationship between human papillomavirus (HPV) and breast cancer using meta- analysis. Materials and Methods: Relevant studies were identified reviewing the national and international databases. We also increased the search sensitivity by investigating the references as well as interview with research centers and experts. Finally, quality assessment and implementation of inclusion/exclusion criteria determined the eligible articles for meta-analysis. Based on the heterogeneity observed among the results of the primary studies, random effects model was used to estimate the pooled prevalence of HPV infection and also pooled odds ratio between HPV and developing breast cancer using Stata SE V. 11 software. Results: This meta- analysis included 11 primary studies investigating the HPV infection prevalence among 1539 Iranian women. Pooled prevalence (95% confidence interval) of HPV infection among Iranian women with breast cancer was estimated as of 23.6% (6.7- 40.5), while, the odds ratio (95% confidence interval) between HPV infection and developing breast cancer was estimated as of 5.7% (0.7- 46.8). Conclusion: This meta- analysis showed a high prevalence of HPV infection among women with breast cancer. We also found that the odds of developing breast cancer among women with breast cancer was more than that of women without breast cancer. PMID:27114791

  6. Computerized Prescriber Order Entry Implementation in a Physician Assistant–Managed Hematology and Oncology Inpatient Service: Effects on Workflow and Task Switching

    PubMed Central

    Hanauer, David A.; Zheng, Kai; Commiskey, Elaine L.; Duck, Mary G.; Choi, Sung W.; Blayney, Douglas W.

    2013-01-01

    Purpose: Little is known about the impact of computerized prescriber order entry (CPOE) systems on inpatient hematology/oncology services. The objective of this study was to quantify the impact of an inpatient CPOE implementation on workflow, with an emphasis on ordering and direct patient care time. Methods: We conducted a direct-observation time-and-motion study of the provider team of a hematology/oncology inpatient service both before and after CPOE implementation, characterizing workflow into 60 distinct activity categories. The provider team comprised physician assistants supervised by attending physicians. Results were adjusted to account for variations in the census. We also conducted an analysis of computer logs to assess CPOE system usage. Results: Study participants were observed for 228.0 hours over 53 observation sessions. There was little change in the proportion of census-adjusted time spent on ordering (10.2% before v 11.4% after) and on direct patient care (50.7% before v 47.8% after). Workflow fragmentation decreased, with providers spending an average of 131.2 seconds on a continuous task before implementation and 218.3 seconds after (P < .01). An eight-fold decrease in the number of pages was observed during the course of the study. Conclusion: CPOE implementation did not negatively affect time available for direct patient care. Workflow fragmentation decreased, which is likely beneficial. PMID:23942926

  7. Sixty Thousand Periodic Variables from the Catalina Surveys

    NASA Astrophysics Data System (ADS)

    Drake, Andrew J.; Graham, M.; Djorgovski, S. G.; Catelan, M.; Mahabal, A. A.; Prieto, J.; Donalek, C.; Christensen, E. J.; Larson, S. M.; Boattini, A.; Gibbs, A.; Grauer, A. D.; Hill, R.; Kowalski, R.; Johnson, J.; Shelly, F.; Torrealba, G.

    2014-01-01

    We have performed an in-depth search for periodic variable stars within the photometry from the Catalina Surveys Data Releases. Our analysis reveals ~40,000 new periodic variable stars with brightness ranging from V=11 to 20, from a region covering ~20,000 square degrees on the sky. Each source is classified based on lightcurve morphology and multi-color photometry from WISE and SDSS. The variable stars discovered include eclipsing binaries, such as Algol, beta Lyrae, W UMa and WD+dM types, and pulsators including delta Scuti's, SX Phe, LPVs, RR Lyrae and Cepheids. We combine these sources with type-ab RR Lyrae from our prior analysis to produce a periodic variable catalog containing 60,000 stars. Using ~5,500 optical spectra from SDSS DR10 we determine the metallicities, surface gravities and radial velocities of the major types. The photometry, classifications and periods will all be made publicly available through the Catalina Surveys data release website.

  8. Assessment of Electrosurgery Burns in Cardiac Surgery

    PubMed Central

    Jalali, Seyyed Mehdi; Moradi, Mohammad; Khalaj, Alireza; Pazouki, Alireza; Tamannaie, Zeinab; Ghanbari, Sajjad

    2015-01-01

    Background: Monopolar surgery is applied mostly in major operations, while bipolar is used in delicate ones. Attention must be paid in electrosurgery application to avoid electrical burns. Objectives: We aimed to assess factors associated with electrosurgery burns in cardiac surgery operating rooms. Patients and Methods: This was a case-control study in which two groups of 150 patients undergoing cardiac surgery in Imam Khomeini Hospital were recruited. Several factors like gender, age, operation duration, smoking, diseases, infection, atopia, , immunosuppressive drugs use, hepatic cirrhosis, and pulmonary diseases were compared between the two groups. Patients were observed for 24 hours for development of any burn related to the operation. Data was analyzed using SPSS v.11.5, by Chi square and T-test. Results: Patients in the two groups were similar except for two factors. DM and pulmonary diseases which showed significant differences (P = 0.005 and P = 0.002 respectively). Seventy-five patients from controls and 35 from the study group developed burns, which was significant (P ˂ 0.0001). Conclusions: None of the factors were significantly related to developing burns. The differences between the two groups highlights the importance of systems modifications to lessen the incidence of burns. PMID:26839854

  9. XO-2b: Transiting Hot Jupiter in a Metal-rich Common Proper Motion Binary

    NASA Astrophysics Data System (ADS)

    Burke, Christopher J.; McCullough, P. R.; Valenti, Jeff A.; Johns-Krull, Christopher M.; Janes, Kenneth A.; Heasley, J. N.; Summers, F. J.; Stys, J. E.; Bissinger, R.; Fleenor, Michael L.; Foote, Cindy N.; García-Melendo, Enrique; Gary, Bruce L.; Howell, P. J.; Mallia, F.; Masi, G.; Taylor, B.; Vanmunster, T.

    2007-12-01

    We report on a V=11.2 early K dwarf, XO-2 (GSC 03413-00005), that hosts a Rp=0.98+/-0.030.01 RJ, Mp=0.57+/-0.06 MJ transiting extrasolar planet, XO-2b, with an orbital period of 2.615857+/-0.000005 days. XO-2 has high metallicity, [Fe/H]=0.45+/-0.02, high proper motion, μtot=157 mas yr-1, and a common proper motion stellar companion with 31" separation. The two stars are nearly identical twins, with very similar spectra and apparent magnitudes. Due to the high metallicity, these early K dwarf stars have a mass and radius close to solar, M*=0.98+/-0.02 Msolar and R*=0.97+/-0.020.01 Rsolar. The high proper motion of XO-2 results from an eccentric orbit (Galactic pericenter, Rper<4 kpc) well confined to the Galactic disk (Zmax~100 pc). In addition, the phase-space position of XO-2 is near the Hercules dynamical stream, which points to an origin of XO-2 in the metal-rich, inner thin disk and subsequent dynamical scattering into the solar neighborhood. We describe an efficient Markov chain Monte Carlo algorithm for calculating the Bayesian posterior probability of the system parameters from a transit light curve.

  10. Theranostic Applications of Lutetium-177 in Radionuclide Therapy.

    PubMed

    Das, Tapas; Banerjee, Sharmila

    2016-01-01

    Lutetium-177 has been widely discussed as a radioisotope of choice for targeted radionuclide therapy. The simultaneous emission of imageable gamma photons [208 keV (11%) and 113 keV (6.4%)] along with particulate β(-) emission [β(max) = 497 keV] makes it a theranostically desirable radioisotope. In the present article, the possibility of using two 177Lu-based agents viz. 177Lu-EDTMP and 177Lu-DOTATATE for theranostic applications in metastatic bone pain palliation (MBPP) and peptide receptor radionuclide therapy (PRRT), have been explored. In the case of 177Lu-EDTMP, the whole-body images obtained are compared with those recorded using 99mTc-MDP in the same patient. On the other hand, pre-therapy images acquired with 177Lu-DOTA-TATE are compared with similar images obtained with standard agents, such as 99mTc-HYNIC-TOC (SPECT) and 68Ga-DOTA-TOC (PET) in the same patient. The advantage of the long physical half-life (T1/2) of 177Lu has been utilized in mapping the pharmacokinetics of two additional agents, 177Lu-labeled hydroxyapatite (HA) in radiation synovectomy of knee joints and 177Lu-HA for therapy of hepatocellular carcinoma. Results of these multiple studies conclusively document the potential of 177Lu as a theranostic radioisotope. PMID:25771364

  11. WASP-17b: AN ULTRA-LOW DENSITY PLANET IN A PROBABLE RETROGRADE ORBIT

    SciTech Connect

    Anderson, D. R.; Hellier, C.; Smalley, B.; Maxted, P. F. L.; Bentley, S. J.; Gillon, M.; Triaud, A. H. M. J.; Queloz, D.; Mayor, M.; Pepe, F.; Segransan, D.; Udry, S.; Hebb, L.; Cameron, A. Collier; Enoch, B.; Horne, K.; Parley, N. R.; West, R. G.; Lister, T. A.; Pollacco, D.

    2010-01-20

    We report the discovery of the transiting giant planet WASP-17b, the least-dense planet currently known. It is 1.6 Saturn masses, but 1.5-2 Jupiter radii, giving a density of 6%-14% that of Jupiter. WASP-17b is in a 3.7 day orbit around a sub-solar metallicity, V = 11.6, F6 star. Preliminary detection of the Rossiter-McLaughlin effect suggests that WASP-17b is in a retrograde orbit (lambda approx -150{sup 0}), indicative of a violent history involving planet-planet or star-planet scattering. WASP-17b's bloated radius could be due to tidal heating resulting from recent or ongoing tidal circularization of an eccentric orbit, such as the highly eccentric orbits that typically result from scattering interactions. It will thus be important to determine more precisely the current orbital eccentricity by further high-precision radial velocity measurements or by timing the secondary eclipse, both to reduce the uncertainty on the planet's radius and to test tidal-heating models. Owing to its low surface gravity, WASP-17b's atmosphere has the largest scale height of any known planet, making it a good target for transmission spectroscopy.

  12. KELT-10b and KELT-11b: Two Sub-Jupiter Mass Planets well-Suited for Atmospheric Characterization in the Southern Hemisphere

    NASA Astrophysics Data System (ADS)

    Rodriguez, Joseph E.

    2015-12-01

    The Kilodegree Extremely Little Telescope (KELT) project is a photometric survey in both the northern and southern hemispheres for transiting planets around bright stars (8 < V < 11), and has discovered 15 planets to date. Of these, several possess unique characteristics that make them especially well suited for study of planet atmospheres. Here, I present the first two discoveries from the KELT-South survey. KELT-10b is an inflated transiting sub-Jupiter mass planet (0.68 MJ) around a V=10.7 early G-star. It has the 3rd deepest transit (1.4%) in the southern hemisphere for a star V < 12.5, making it a great target for transmission spectroscopy. KELT-11b is a highly inflated transiting Saturn mass planet (0.22 MJ) orbiting one of the brightest planet-hosting stars in the southern hemisphere. Interestingly, KELT-11b's host star is a clear sub-giant star (log(g) ~ 3.7). I will discuss their impact for atmospheric characterization. For example, the highly inflated nature of the KELT-11b planet provides the ability to study a sub-Jupiter atmosphere at very low planetary gravity, while the sub-giant nature of its host star allows us to study the effects of post main sequence evolution of a host star on a hot Jupiter.

  13. Determination of Two-Liquid Mixture Composition by Assessing Dielectric Parameters 1. Precise Measuring System / Divu Šķidrumu Maisījuma Sastāva Noteikšana, Izvērtējot to Dielektriskos Parametrus 1. Precīza Mērīšanas Sistēma

    NASA Astrophysics Data System (ADS)

    Vilitis, O.; Shipkovs, P.; Merkulovs, D.

    2013-08-01

    Concentration measurements are important in bioethanol industries, in the R&D areas, for chemical, medical and microbiological analyses and processing as well as for diagnostics, manufacturing, etc. The overview shows development of the structural design of a system for measuring the concentration of solutions and mixtures consisting of two dielectric liquids. The basic principles of the system's design are given along with relevant equations. The concentration of dielectric liquids is measured using devices with capacitive sensors (1-300 pF). The operational frequency of the developed measuring system is 100.000 kHz. Configuration of the system excludes some errors usually arising at measurements, and broadens its applicability. For testing, the system was calibrated for measuring the concentration of anhydrous ethanol + de-ionized water mixture. Experimental results have shown a stable resolution of ±0.005 pF at measuring the sensor capacitance and a reproducible resolution better than ±0.01% at measuring the ethanol volume concentration Rakstā esam parādījuši iespējas izveidot augstas precizitātes, kompaktu, lētu un ērtu lietošanai dielektrisku šķidrumu mērīšanas sistēmu koncentrācijas noteikšanai. Šī sistēma ir piemērojama kapacitīviem sensoriem, kuru kapacitāte ir atkarīga no sensora izveidojuma kā arī mērāmā šķidruma dielektriskās konstantes vērtības, un kapacitāte var tikt noteikta pie frekvences 100,000 kHz robežās no 1 F līdz 300 pF. Mērīšanas sistēmas pārbaudei, sistēma tika kalibrēta etanola koncentrācijas mērīšanai tilpuma procentos sertificēta bezūdens etanola un dejonizēta ūdens maisījumiem. Pārbaužu rezultāti pierādīja, ka sensora kapacitātes vērtības ir stabili nosakāmas ar izšķirtspēju ne mazāku par ±0,005 pF. Sensora kapacitāšu vērtībām atbilstošā etanola tilpuma koncentrācijas atkārtojamu mērījumu izšķirtspēja visā mērīšanas diapazonā nebija mazāka par ±0

  14. The Role of Partial Recording Protocols in reporting prevalence and severity of Dental Fluorosis

    PubMed Central

    Akinkugbe, Aderonke; Iafolla, Timothy; Chattopadhyay, Amit; Garcia, Isabel; Adams, Amy; Kingman, Albert

    2014-01-01

    Objectives To evaluate the role of partial recording protocols (PRPs) in reporting prevalence and severity of dental fluorosis and assess whether prevalence/severity estimates derived from PRPs differ by race/ethnicity. Methods Data from the National Health and Nutrition Examination Survey (NHANES) for the years 1999-2004 were analyzed with Stata® v.11. Prevalence of dental fluorosis obtained from a full mouth examination (28 teeth gold standard) was compared to estimates derived from four subsets of teeth (maxillary canine-to-canine; maxillary 1st premolar to 1st premolar; allpremolars; all-molars). Sensitivity, Negative Predictive Value (NPV), absolute bias, and correction factors were calculated against gold standard estimate. Analysis was stratified according to race/ethnicity to assess differences in estimates derived from PRPs. Results All subsets underestimated prevalence albeit to varying degrees. Two subsets (allpremolars and all-molars) had prevalence and severity estimates closest to gold standard estimates. The all-molar subset (8 teeth) recorded the highest sensitivity (84.5%) and the lowest absolute bias (3.5%) of all subsets relative to gold standard. Subsets derived from aesthetically relevant teeth produced the lowest fluorosis prevalence. For instance, the maxillary canine-to-canine subset underestimated prevalence by 9.5%; incorporating the maxillary first premolars in the span improved prevalence estimate by 31%. Among non-Hispanic Whites, the all-premolars subset produced estimates closest to gold standard while the all-molars subset produced estimates closest to the gold standard among non-Hispanic Blacks and Hispanics. Conclusion While the majority of dental fluorosis in the United States is very mild, concerns regarding its growing prevalence underscore the need for careful monitoring. The use of PRPs offers an alternative method of assessment, with validity of reported prevalence and severity dependent on choice of subset. PMID:24995860

  15. Prevalence of Head Lice Infestation and Its Associated Factors among Primary School Students in Iran: A Systematic Review and Meta-analysis

    PubMed Central

    Moosazadeh, Mahmood; Afshari, Mahdi; Keianian, Hormoz; Nezammahalleh, Asghar; Enayati, Ahmad Ali

    2015-01-01

    Objectives Head lice infestation is one of the most important health problems, generally involving children aged 5–13 years. This study aims to estimate the prevalence of head lice infestation and its associated factors among primary school children using systematic review and meta-analysis methods. Methods Different national and international databases were searched for selecting the relevant studies using appropriate keywords, Medical Subject Heading terms, and references. Relevant studies with acceptable quality for meta-analysis were selected having excluded duplicate and irrelevant articles, quality assessment, and application of inclusion/exclusion criteria. With calculating standard errors according to binomial distribution and also considering the Cochrane's Q test as well as I-squared index for heterogeneity, pediculosis prevalence rate was estimated using Stata SE V.11 software. Results Forty studies met the inclusion criteria of this review and entered into the meta-analysis including 200,306 individuals. Using a random effect model, the prevalence (95% confidence interval) of head lice infestation among primary school children was estimated as 1.6% (1.2–2.05), 8.8% (7.6–9.9), and 7.4% (6.6–8.2) for boys, girls, and all the students, respectively. The infestation rate was found to be associated with low educational level of parents, long hair, family size, mother's job (housewife), father's job (worker/unemployed), using a common comb, lack of bathrooms in the house, and a low frequency of bathing. Conclusion This meta-analysis revealed that the prevalence of head lice infestation among Iranian primary school children is relatively high with more prevalence among girls. We also found that economic, social, cultural, behavioral, and hygienic factors are associated with this infestation. PMID:26835244

  16. Microglial response to Alzheimer's disease is differentially modulated by voluntary wheel running and enriched environments.

    PubMed

    Rodríguez, J J; Noristani, H N; Verkhratsky, A

    2015-03-01

    Alzheimer's disease (AD) is an untreatable neurodegenerative disease that deteriorates memory. Increased physical/cognitive activity reduces dementia risk by promoting neuronal and glial response. Although few studies have investigated microglial response in wild-type rodents following exposure to physical/cognitive stimulation, environmental-induced changes of microglia response to AD have been neglected. We investigated effects of running (RUN) and enriched (ENR) environments on numerical density (N v, #/mm(3)) and morphology of microglia in a triple transgenic (3×Tg-AD) mouse model of AD that closely mimics AD pathology in humans. We used immunohistochemical approach to characterise microglial domain by measuring their overall cell surface, volume and somata volume. 3×Tg-AD mice housed in standard control (STD) environment showed significant increase in microglial N v (11.7 %) in CA1 stratum lacunosum moleculare (S.Mol) of the hippocampus at 12 months compared to non-transgenic (non-Tg) animals. Exposure to combined RUN and ENR environments prevented an increase in microglial N v in 3×Tg-AD and reduced microglial numbers to non-Tg control levels. Interestingly, 3×Tg-AD mice housed solely in ENR environment displayed significant decrease in microglial N v in CA1 subfield (9.3 % decrease), stratum oriens (11.5 % decrease) and S.Mol (7.6 % decrease) of the hippocampus compared to 3×Tg-AD mice housed in STD environment. Morphological analysis revealed microglial hypertrophy due to pronounced increase in microglia surface, volume and somata volume (61, 78 and 41 %) in 3×Tg-AD mice housed in RUN (but not in ENR) compared to STD environment. These results indicate that exposure to RUN and ENR environments have differential effects on microglial density and activation-associated changes in microglial morphology. PMID:24374506

  17. The Rotational Spectrum of Acrylonitrile to 1.67 THz

    NASA Astrophysics Data System (ADS)

    Kisiel, Zbigniew; Pszczółkowski, Lech; Drouin, Brian J.; Brauer, Carolyn S.; Yu, Shanshan; Pearson, John C.

    2009-06-01

    Acrylonitrile (vinyl cyanide) is an astrophysical molecule of sufficient abundance for detection of its ^{13}C isotopologues. In fact this molecule has been identified as one of the 'weed' species, that will contribute a plethora of lines in broadband submillimetre spectra from the new tools of radioastronomy, such as the Herschel Space Observatory or ALMA. We presently report the first stage in extending the knowledge of the rotational spectrum of acrylonitrile well into the THz region. The spectrum was recorded with the jpl cascaded harmonic multiplication instrument in the form of several broadband segments covering 390-540, 818-930, 967-1160, and 1576-1669 GHz. The analysis of the ground state spectrum has been extended up to J=128, K_a=29, and a combined data set of over 3000 fitted lines. It is found that transitions in all measurable vibrational states, inclusive of the ground state, show evidence of perturbations with other states. Several different perturbations between the ground state and v_{11}=1 at 228 cm^{-1} were identified and have been successfully fitted, resulting in E_{11}=228.29994(3) cm^{-1}, to compare with a direct far-infrared value of 228.83(18) cm^{-1}. H.S.P.Müller et al., J. Mol. Spectrosc., 251, 319-325 (2008). B.J.Drouin, F.W.Maiwald, J.C.Pearson, Rev. Sci. Instrum., 76, 093113-1-10 (2005). A.R.H.Cole, A.A.Green, J. Mol. Spectrosc., 48, 246-253 (1973).

  18. Spatio-temporal seasonal drought patterns in Europe from 1950 to 2015

    NASA Astrophysics Data System (ADS)

    Spinoni, Jonathan; Naumann, Gustavo; Vogt, Jürgen

    2016-04-01

    Drought is one of the natural disasters with severe impacts in Europe, not only in areas which frequently experience water scarcity such as the Mediterranean, but also in temperate or continental climates such as Central and Eastern Europe and even in cold regions such as Scandinavia and Iceland. In this study the spatio-temporal patterns of seasonal meteorological droughts in Europe between 1950 and 2015 are investigated using the Standardized Precipitation Index (SPI) and the Standardized Precipitation-Evapotranspiration Index (SPEI). Since the focus is on the analysis of seasonal drought trends, indicators were calculated for 3 monthly accumulation periods. The input variables of precipitation and temperature were derived from E-OBS grids (v11-v12) at a spatial resolution of 0.25°x0.25°. Seasonal trends of drought frequency and severity were analyzed for moderate (SPI or SPEI <-1.0) and extreme (SPI or SPEI <-2.0) events during the periods 1950-2015 and 1981-2015. For the moderate events, results of the SPI analysis (precipitation driven) demonstrate a significant tendency towards less frequent and severe droughts in Northern Europe and Russia, especially in winter and spring; oppositely, an increasing trend is visible in Southern Europe, mainly in spring and summer. According to the SPEI analysis (precipitation and temperature driven) Northern Europe shows wetting patterns, while Southern and Eastern Europe show a more remarkable drying tendency, especially in summer and autumn for drought frequency and in every season for drought severity. The evolution towards drier conditions is more relevant from 1981 onwards, both in terms of frequency and severity. This is especially true for Central Europe in spring, for the Mediterranean in summer, and for Eastern Europe in autumn. Extreme events follow similar patterns, but in autumn no spatially coherent trend can be found.

  19. The physiological effects of cycling on tandem and single bicycles

    PubMed Central

    Seifert, J; Bacharach, D; Burke, E; Langenfeld, M; Snyder, A

    2003-01-01

    Objective: The purpose of this field study was to compare the physiological responses from cycling on a tandem road bicycle to those from cycling on a single road bicycle. Methods: Nine pairs of experienced, recreational tandem cyclists rode a tandem or their single bicycle for 5 min at each velocity of 19.3, 22.5, 25.8, and 29.0 kph on a flat, paved surface. Heart rate (HR), rating of perceived exertion (RPE), and lactic acid (LA) data were collected after each interval. Results: Riding a tandem resulted in lower HR, RPE, and LA mean values across the four velocities compared to the single bicycle. Mean (SD) HR, RPE, and LA for tandem and single bicycles were 126 (20.7) v 142 (20.1) bpm, 10.1 (1.7) v 11.3 (2.6), and 1.46 (1.0) mM/L v 2.36 (1.7) mM/L, respectively. No position differences were observed between the captain and stoker (front and rear positions) when both were on the tandem. Stokers had significantly lower HR, LA, and RPE values when they rode a tandem compared to a single bicycle. No statistical differences were observed between bicycles for the captains. When on the single bicycle, captains exhibited significantly lower HR, RPE, and LA values than stokers. Conclusion: Cycling on a tandem resulted in lower physiological stress than when cycling at the same velocity on a single bicycle. Cyclists were able to ride from 4.8–8.0 kph faster on a tandem than on a single bicycle at similar physiological stress. Apparently, stokers can add to power output on a tandem without adding significantly to wind resistance. PMID:12547743

  20. The polyphase resonant converter modulator for pulse power and plasma applications

    SciTech Connect

    Reass, W. A.; Baca, D. M.; Doss, James D.; Gribble, R.; North, W. R.

    2002-01-01

    This paper describes a new technique to generate high voltage pulses (100 kV and up) with high peak power (10 MW and up) and high average power (1 MW and up) from a low voltage input source (e.g. +/- 1.2 kV). This technology is presently being used to provide cathode pulse modulation for the Spallation Neutron Source (SNS) accelerator klystron RF amplifiers, which operate to 140 kV 11 MW peak power and 1.1 MW average power. The design of the modulator, referred to as the Polyphase Resonant Converter-Modulator takes advantage of high-power component advances, in response to the needs of the traction motor industry (in particular, railroad locomotives), such as Insulated Gate Bipolar Transistors (IGBT's) and self-clearing metallized hazy polypropylene capacitors. In addition, the use of amorphous nanocrystalline transformer core alloy permits high frequency voltage and current transformation with low loss and small size. Other unique concepts embodied in the converter-modulator topology are polyphase resonant voltage multiplication and resonant rectification. These techniques further reduce size and improve electrical efficiency. Because of the resonant conversion techniques, electronic 'crowbars' and other load protective networks are not required. A shorted load detunes the circuit resonance and little power transfer can occur. This yields a high-power, high-voltage system that is inherently self-protective. To provide regulated output voltages, Pulse Width Modulation (PWM) of the individual IGBT pulses is used. A Digital signal Processor (DSP) is used to control the IGBT's, with adaptive feed forward and feedback control algorithms that improve pulse fidelity. The converter-modulator has many attributes that make it attractive to various pulse power and plasma applications such as high power RF sources, neutral beam modulators, and various plasma applications. This paper will review the design as used for the SNS accelerator and speculate on related plasma

  1. VizieR Online Data Catalog: VRI light curves of TT Her (Terrell+, 2014)

    NASA Astrophysics Data System (ADS)

    Terrell, D.; Nelson, R. H.

    2016-04-01

    In April of 2005, 2006, and 2007 R.H.N. took a total of nine medium resolution (reciprocal dispersion=10Å/mm, R=10000) spectra at the Dominion Astrophysical Observatory (DAO) in Victoria, BC using the 1.8m Plaskett Telescope. The exposure time was usually 1hr and the spectral coverage was approximately 5000-5260Å. The log of the spectroscopic observations is given in Table1. Photometric observations in the VRCIC photometric passbands were undertaken by R.H.N. at his private observatory in Prince George, BC, Canada in May and June of 2008. A total of 392 frames in V, 413 in RC, and 393 in IC were taken. Standard reduction techniques (bias subtraction, dark subtraction, and flat-fielding) were done and aperture photometry performed. Differential photometry was then performed with GSC 1525-0805 (V=9.82+/-0.03 and B-V=0.72+/-0.03 from the Tycho-2 catalog; Hog et al. 2000, cat. I/259) as the comparison star and GSC 1525-0939 (V=11.73+/-0.07 and B-V=0.82+/-0.07 from Data Release 7 of the APASS survey; Henden et al., 2012JAVSO..40..430H; see DR9 in Henden et al. 2016, cat. II/336) as the check star. No variation in the comparison and check stars greater than 0.01mag was detected, and the precision of the differential magnitudes for TT Her was about 0.005mag in each filter. The instrumental magnitude differences are given in Table2. (2 data files).

  2. Follow-up of N400 in the Rehabilitation of First-episode Schizophrenia

    PubMed Central

    Du, Xiang-Dong; Zhang, Guang-Ya; Yang, Yong; Li, Zhe; Pan, Wen; Yin, Guang-Zhong; Dong, Ri-Xia; Gai, Hai-Jun; Ye, Gang; Yang, Jian-Gong; Yuan, Ying; Pan, Neng-Rong; Li, Wei-Qin; Xu, Xiao-Wen; Chen, Xing-Shi

    2015-01-01

    Background: The N400 component of event-related potentials (ERP) has recently drawn widespread attention at home and abroad. This study was to explore the relationship between N400 changes and risperidone treatment and rehabilitation in first-episode schizophrenia (FES). Methods: ERP component N400 was recorded by Guangzhou Runjie WJ-1 ERP instruments, in 58 FES before and 6 months, 15 months after risperidone treatment, and in 62 normal controls. The patients’ syndromes were assessed by Positive and Negative Syndrome Scale (PANSS). And the stimuli are Chinese sentences with matching (congruent) or mismatching (incongruent) ending words. Results: N400 latencies were prolonged, and amplitudes were decreased in Cz, Pz, Fz, C3, C4, in FES compared with in NC, before treatment. The prolonged N400 latencies and decreased amplitudes were negatively correlated with the patients’ positive scale and total scale of PANSS. There are significant differences of N400 amplitudes and latencies in 6 months and 15 months follow-up after treatment. Before treatment, 6 months and 15 months after treatment, N400 latencies are 446 ± 35 ms, 440 ± 37 ms, 414 ± 31 ms (F = 9.72, P < 0.01) in incongruent situation; N400 amplitudes are 5.2 ± 4.6 μV, 5.7 ± 4.8 μV, 7.3 ± 5.0 μV (F = 2.06, P > 0.05) in congruent situation, and 8.5 ± 5.9 μV, 10.1 ± 5.0 μV, 11.9 ± 7.0 μV (F = 3.697, P < 0.05) in incongruent situation. Conclusions: N400 could be used to predict the effects of treatment of schizophrenia to some degree. The linguistic and cognitive impairment in schizophrenia can be improved by antipsychotic drugs. PMID:26265616

  3. Independent Review of E2100: A Phase III Trial of Bevacizumab Plus Paclitaxel Versus Paclitaxel in Women With Metastatic Breast Cancer

    PubMed Central

    Gray, Robert; Bhattacharya, Suman; Bowden, Christopher; Miller, Kathy; Comis, Robert L.

    2009-01-01

    Purpose E2100, an open-label, randomized, phase III trial conducted by the Eastern Cooperative Oncology Group (ECOG), demonstrated a significant improvement in progression-free survival (PFS) and overall response rate (ORR) with paclitaxel plus bevacizumab compared with paclitaxel alone as initial chemotherapy for patients with HER2-negative metastatic breast cancer. Methods An independent, blinded review of radiologic and clinical data was performed, assessing progression and response according to Response Evaluation Criteria in Solid Tumors. In addition, ECOG's investigator assessments were reanalyzed using the same methods applied to the independent review. The primary end point was PFS as assessed by an independent review facility (IRF). Results The addition of bevacizumab to paclitaxel resulted in a statistically significant improvement in PFS using both the IRF and investigator assessments. Hazard ratios for PFS (0.48, 95% CI, 0.385 to 0.607; P < .0001 for the IRF v 0.42, 95% CI, 0.34 to 0.52; P < .0001 for ECOG investigators) and the improvement in median PFS (11.3 v 5.8 months for the IRF v 11.4 v 5.8 months for ECOG investigators) were similar. Among patients with measurable disease at baseline, the IRF-assessed ORR was significantly higher in patients treated with paclitaxel and bevacizumab (48.9% v 22.2%; P < .0001). Conclusion The risk of progression was reduced by more than half and the ORR more than doubled with the addition of bevacizumab to weekly paclitaxel in both analyses, confirming a substantial and robust bevacizumab treatment effect. The consistency between the IRF and ECOG analyses validates the original data previously reported by ECOG in this open-label trial. PMID:19720913

  4. ADVANCES IN THE RXTE PROPORTIONAL COUNTER ARRAY CALIBRATION: NEARING THE STATISTICAL LIMIT

    SciTech Connect

    Shaposhnikov, Nikolai; Jahoda, Keith; Markwardt, Craig; Swank, Jean; Strohmayer, Tod

    2012-10-01

    During its 16 years of service, the Rossi X-Ray Timing Explorer (RXTE) mission has provided an extensive archive of data, which will serve as a primary source of high cadence observations of variable X-ray sources for fast timing studies. It is, therefore, very important to have the most reliable calibration of RXTE instruments. The Proportional Counter Array (PCA) is the primary instrument on board RXTE which provides data in 3-50 keV energy range with submillisecond time resolution in up to 256 energy channels. In 2009, the RXTE team revised the response residual minimization method used to derive the parameters of the PCA physical model. The procedure is based on the residual minimization between the model spectrum for Crab Nebula emission and a calibration data set consisting of a number of spectra from the Crab and the on-board Am{sub 241} calibration source, uniformly covering the whole RXTE mission operation period. The new method led to a much more effective model convergence and allowed for better understanding of the PCA energy-to-channel relationship. It greatly improved the response matrix performance. We describe the new version of the RXTE/PCA response generator PCARMF v11.7 (HEASOFT Release 6.7) along with the corresponding energy-to-channel conversion table (version e05v04) and their difference from the previous releases of PCA calibration. The new PCA response adequately represents the spectrum of the calibration sources and successfully predicts the energy of the narrow iron emission line in Cas-A throughout the RXTE mission.

  5. WASP-80b: a gas giant transiting a cool dwarf

    NASA Astrophysics Data System (ADS)

    Triaud, A. H. M. J.; Anderson, D. R.; Collier Cameron, A.; Doyle, A. P.; Fumel, A.; Gillon, M.; Hellier, C.; Jehin, E.; Lendl, M.; Lovis, C.; Maxted, P. F. L.; Pepe, F.; Pollacco, D.; Queloz, D.; Ségransan, D.; Smalley, B.; Smith, A. M. S.; Udry, S.; West, R. G.; Wheatley, P. J.

    2013-03-01

    We report the discovery of a planet transiting the star WASP-80 (1SWASP J201240.26-020838.2; 2MASS J20124017-0208391; TYC 5165-481-1; BPM 80815; V = 11.9, K = 8.4). Our analysis shows this is a 0.55 ± 0.04 Mjup, 0.95 ± 0.03 Rjup gas giant on a circular 3.07 day orbit around a star with a spectral type between K7V and M0V. This system produces one of the largest transit depths so far reported, making it a worthwhile target for transmission spectroscopy. We find a large discrepancy between the vsini⋆ inferred from stellar line broadening and the observed amplitude of the Rossiter-McLaughlin effect. This can be understood either by an orbital plane nearly perpendicular to the stellar spin or by an additional, unaccounted for source of broadening. Using WASP-South photometric observations, from Sutherland (South Africa), confirmed with the 60 cm TRAPPIST robotic telescope, EulerCam, and the CORALIE spectrograph on the Swiss 1.2 m Euler Telescope, and HARPS on the ESO 3.6 m (Prog ID 089.C-0151), all three located at La Silla Observatory, Chile.Radial velocity and photometric data are available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr(130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/551/A80

  6. Restricting night-time eating reduces daily energy intake in healthy young men: a short-term cross-over study.

    PubMed

    LeCheminant, James D; Christenson, Ed; Bailey, Bruce W; Tucker, Larry A

    2013-12-14

    Few experimental data are available to support the notion that reducing night-time eating changes total daily energy intake (EI) or body weight in healthy adults. The present study primarily examined the short-term effect of night eating restriction (NER) on daily EI in healthy young men. It secondarily examined body weight and moods associated with NER. Using a cross-over design, twenty-nine men (20·9 (sd 2·5) years; 24·4 (sd 2·5) kg/m²) initiated a 2-week NER intervention (elimination of EI from 19.00 to 06.00 hours) and a 2-week control condition, counterbalanced and separated by a 1-week washout period. EI and macronutrient intake were assessed using computerised, multiple-pass 24 h food recalls, body weight via a digital scale and mood using the Profile of Mood States survey. Of the twenty-nine participants, twenty-seven (93 %) completed all aspects of the study. During the NER condition, the participants consumed less total energy per d than during the control condition (10 125 v. 11 146 kJ/d; F= 6·41; P= 0·018). During the NER condition, no energy was reported consumed between 19.00 and 06.00 hours; however, during the control condition, the energy intake of participants was 2920 (sd 1347) kJ/d between 19.00 and 06.00 hours. There was a significant difference in weight change between the NER (-0·4 (sd 1·1) kg) and control (+0·6 (sd 0·9) kg) conditions (F= 22·68; P< 0·001). Differences in total mood score or mood subscales between the NER and control conditions were not apparent (P>0·05). These findings provide support for NER decreasing short-term EI in healthy young men. PMID:23702187

  7. Comparative diagnostic yield of cone beam CT reconstruction using various software programs on the detection of vertical root fractures

    PubMed Central

    Melo, S L S; Haiter-Neto, F; Correa, L R; Scarfe, W C; Farman, A G

    2013-01-01

    Objectives: To evaluate the effect on diagnostic yield in the detection of experimentally induced vertical root fractures on cone beam CT images using four dental software program. Methods: 190 single-rooted extracted human teeth were divided into three groups according to the pulp canal status: unrestored (UR), filled with gutta-percha (GP) and restored with a metallic custom post (Post). One-half of the sample of each group was artificially fractured and the segments repositioned. All teeth were scanned on a cone beam CT device at 0.2 mm nominal voxel resolution (i-CAT Platinum; Imaging Sciences International, Hatfield, PA). The data were exported as digital imaging and communications in medicine files and imported into Dolphin Imaging & Management Solutions, v. 11.5 (Patterson Dental Supply Inc., St Paul, MN), InVivoDental, v. 5.0 (Anatomage Inc., San Jose, CA) and Kodak Dental Imaging Software 3D module, v. 2.1.11 (Carestream Health Inc., Rochester, NY) software. Cross-sectional images in the acquisition (using Xoran CAT™, v. 3.0.34 software; Xoran Technologies, Ann Arbor, MI) and additional software were presented to three calibrated oral radiologists who rated the presence or absence of root fracture on a five-point scale. Receiver operating characteristic analysis was performed, and treatment comparisons compared by analysis of variance and pairwise comparisons were performed using Tukey's test at an a priori value of α < 0.05%. Results: All dental software performed equally at detecting fractures. Fractures were significantly more difficult to detect when posts were present. Conclusions: The diagnosis of root fracture is software-independent. The presence of an intracanal metallic post significantly decreases the detection of artificially created root fractures. PMID:23906974

  8. Instructions to “push as hard as you can” improve average chest compression depth in dispatcher-assisted Cardiopulmonary Resuscitation

    PubMed Central

    Mirza, Muzna; Brown, Todd B.; Saini, Devashish; Pepper, Tracy L; Nandigam, Hari Krishna; Kaza, Niroop; Cofield, Stacey S.

    2008-01-01

    Background and Objective Cardiopulmonary Resuscitation (CPR) with adequate chest compression depth appears to improve first shock success in cardiac arrest. We evaluate the effect of simplification of chest compression instructions on compression depth in dispatcher-assisted CPR protocol. Methods Data from two randomized, double-blinded, controlled trials with identical methodology were combined to obtain 332 records for this analysis. Subjects were randomized to either modified Medical Priority Dispatch System (MPDS) v11.2 protocol or a new simplified protocol. The main difference between the protocols was the instruction to “push as hard as you can” in the simplified protocol, compared to “push down firmly 2 inches (5cm)” in MPDS. Data were recorded via a Laerdal® ResusciAnne® SkillReporter™ manikin. Primary outcome measures included: chest compression depth, proportion of compressions without error, with adequate depth and with total release. Results Instructions to “push as hard as you can”, compared to “push down firmly 2 inches (5cm)”, resulted in improved chest compression depth (36.4 vs 29.7 mm, p<0.0001), and improved median proportion of chest compressions done to the correct depth (32% vs <1%, p<0.0001). No significant difference in median proportion of compressions with total release (100% for both) and average compression rate (99.7 vs 97.5 per min, p<0.56) was found. Conclusions Modifying dispatcher-assisted CPR instructions by changing “push down firmly 2 inches (5cm)” to “push as hard as you can” achieved improvement in chest compression depth at no cost to total release or average chest compression rate. PMID:18635306

  9. Transversal and longitudinal mode selections in double-corrugation coaxial slow-wave devices

    NASA Astrophysics Data System (ADS)

    Ge, Xingjun; Zhong, Huihuang; Qian, Baoliang; Liu, Lie; Liu, Yonggui; Li, Limin; Shu, Ting; Zhang, Jiande

    2009-06-01

    To reduce the dimensions of relativistic backward wave oscillators (RBWOs) operating in the low frequency regime of less than 2 GHz, the theory of transversal and longitudinal mode selections are introduced in this paper. The transversal mode selection is achieved using the property of "surface wave" of the coaxial slow-wave structure (SWS) to excite the quasi transverse electromagnetic (quasi-TEM) mode without the higher transverse magnetic (TM) modes and it is proved that the coaxial SWS may decrease the transversal dimension of the SWS sections. In addition, the S-parameter method is employed to investigate the longitudinal resonant characteristic of the finite-length SWS, and the scheme of longitudinal mode selection is put forward. It is proposed that the introduction of a well-designed coaxial extractor to slow-wave devices can help to achieve the longitudinal mode selection and reduce the period number of the SWS, which not only can make the devices more compact, but also can avoid the destructive competition between various longitudinal modes, therefore can enhance the efficiency and stabilize the frequency. To sum up, the physical mechanisms of transversal and longitudinal mode selections ensure that the microwave is produced with a single mode and a narrow band. Based on the above discussion, a compact L-band coaxial RBWO is investigated and optimized in detail with the particle-in-cell KARAT code (V. P. Tarakanov, Berkeley Research Associates, Inc., 1992). In simulation, the L-band coaxial RBWO, driven by a 700 kV, 11 kA electron beam, comes to a nonlinear steady state in 20 ns. High-power microwave of quasi-TEM mode is generated with an average power of 2.66 GW, a frequency of 1.6 GHz, and power conversion efficiency of 34.5% in durations of 30-60 ns.

  10. Assays of polychlorinated biphenyl congeners and co-contaminated heavy metals in the transgenic Arabidopsis plants carrying the recombinant guinea pig aryl hydrocarbon receptor-mediated β-glucuronidase reporter gene expression system.

    PubMed

    Shimazu, Sayuri; Ohta, Masaya; Ohkawa, Hideo; Ashida, Hitoshi

    2012-01-01

    The transgenic Arabidopsis plant XgD2V11-6 carrying the recombinant guinea pig (g) aryl hydrocarbon receptor (AhR)-mediated β-glucuronidase (GUS) reporter gene expression system was examined for assay of polychlorinated biphenyl (PCB) congeners and co-contaminated heavy metals. When the transgenic Arabidopsis plants were treated with PCB126 (toxic equivalency factor; TEF: 0.1) and PCB169 (TEF: 0.03), the GUS activity of the whole plants was increased significantly. After treatment with PCB80 (TEF: 0), the GUS activity was nearly the same level as that treated with 0.1% dimethylsulfoxide (DMSO) as a vehicle control. After exposure to a 1:1 mixture of PCB126 and PCB169, the GUS activity was increased additively. However, after exposure to a mixture of PCB126 and PCB80, the GUS activity was lower than that of the treatment with PCB126 alone. Thus, PCB80 seemed to be an antagonist towards AhR. When the transgenic plants were treated with each of the heavy metals Fe, Cu, Zn, Cd and Pb together with PCB126, Cd and Pb increased the PCB126-induced GUS activity. On the other hand, Fe, Cu and Zn did not affect the PCB126-induced GUS activity. In the presence of the biosurfactant mannosylerythritol lipid-B (MEL-B) and the carrier protein bovine serum albumin (BSA), the PCB126-induced GUS activity was increased, but the Cd-assisted PCB126-induced GUS activity was not affected. Thus, MEL-B and BSA seemed to increase uptake and transport of PCB126, respectively. PMID:22938576

  11. Molecular identification of adenoviruses associated with respiratory infection in Egypt from 2003 to 2010

    PubMed Central

    2014-01-01

    Background Human adenoviruses of species B, C, and E (HAdV-B, –C, -E) are frequent causative agents of acute respiratory infections worldwide. As part of a surveillance program aimed at identifying the etiology of influenza-like illness (ILI) in Egypt, we characterized 105 adenovirus isolates from clinical samples collected between 2003 and 2010. Methods Identification of the isolates as HAdV was accomplished by an immunofluorescence assay (IFA) and confirmed by a set of species and type specific polymerase chain reactions (PCR). Results Of the 105 isolates, 42% were identified as belonging to HAdV-B, 60% as HAdV–C, and 1% as HAdV-E. We identified a total of six co-infections by PCR, of which five were HAdV-B/HAdV-C co-infections, and one was a co-infection of two HAdV-C types: HAdV-5/HAdV-6. Molecular typing by PCR enabled the identification of eight genotypes of human adenoviruses; HAdV-3 (n = 22), HAdV-7 (n = 14), HAdV-11 (n = 8), HAdV-1 (n = 22), HAdV-2 (20), HAdV-5 (n = 15), HAdV-6 (n = 3) and HAdV-4 (n = 1). The most abundant species in the characterized collection of isolates was HAdV-C, which is concordant with existing data for worldwide epidemiology of HAdV respiratory infections. Conclusions We identified three species, HAdV-B, -C and -E, among patients with ILI over the course of 7 years in Egypt, with at least eight diverse types circulating. PMID:24479824

  12. Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk.

    PubMed

    Ren, J; He, B Z; Zhang, T S; Lu, S P; Yan, T

    2016-01-01

    The aim of this meta-analysis was to assess the association between a polymorphism (-3860 G > A) in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer susceptibility. Relevant studies were retrieved from the PubMed and EMBase databases, and additionally evaluated for conformance with the inclusion criteria. The odds ratios (ORs) and their 95% confidence intervals (95%CIs) in all selected studies were used to assess the relationship between the CYP1A2 -3860 G > A polymorphism and lung cancer risk. The data was pooled using Stata v.11. Six studies, comprising 1168 lung cancer patients and 1598 controls, were included in this meta-analysis. We found no correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk in any of the models (AA vs GG: OR = 4.79, 95%CI = 0.03-702.67; GA vs GG: OR = 1.33, 95%CI = 0.74-2.39; dominant model: OR = 1.41, 95%CI = 0.69-2.90; recessive model: OR = 4.07, 95%CI = 0.04-368.35). Moreover, we observed no statistically significant association between CYP1A2 -3860 G > A and lung cancer susceptibility when stratified by the ethnicity of the sample populations, sample size, and study quality, except in a low-quality study. Our findings indicated that the -3860 G > A polymorphism in CYP1A2 might not be a risk factor for lung cancer. PMID:27323197

  13. SU-D-213-04: Accounting for Volume Averaging and Material Composition Effects in An Ionization Chamber Array for Patient Specific QA

    SciTech Connect

    Fugal, M; McDonald, D; Jacqmin, D; Koch, N; Ellis, A; Peng, J; Ashenafi, M; Vanek, K

    2015-06-15

    Purpose: This study explores novel methods to address two significant challenges affecting measurement of patient-specific quality assurance (QA) with IBA’s Matrixx Evolution™ ionization chamber array. First, dose calculation algorithms often struggle to accurately determine dose to the chamber array due to CT artifact and algorithm limitations. Second, finite chamber size and volume averaging effects cause additional deviation from the calculated dose. Methods: QA measurements were taken with the Matrixx positioned on the treatment table in a solid-water Multi-Cube™ phantom. To reduce the effect of CT artifact, the Matrixx CT image set was masked with appropriate materials and densities. Individual ionization chambers were masked as air, while the high-z electronic backplane and remaining solid-water material were masked as aluminum and water, respectively. Dose calculation was done using Varian’s Acuros XB™ (V11) algorithm, which is capable of predicting dose more accurately in non-biologic materials due to its consideration of each material’s atomic properties. Finally, the exported TPS dose was processed using an in-house algorithm (MATLAB) to assign the volume averaged TPS dose to each element of a corresponding 2-D matrix. This matrix was used for comparison with the measured dose. Square fields at regularly-spaced gantry angles, as well as selected patient plans were analyzed. Results: Analyzed plans showed improved agreement, with the average gamma passing rate increasing from 94 to 98%. Correction factors necessary for chamber angular dependence were reduced by 67% compared to factors measured previously, indicating that previously measured factors corrected for dose calculation errors in addition to true chamber angular dependence. Conclusion: By comparing volume averaged dose, calculated with a capable dose engine, on a phantom masked with correct materials and densities, QA results obtained with the Matrixx Evolution™ can be significantly

  14. Retrieving of Microphysical Properties of Spheroidal Particles in the Atmosphere-Surface System

    NASA Astrophysics Data System (ADS)

    Korkin, S.; Lyapustin, A.

    2013-12-01

    In this presentation, we continue our study of the Levenberg-Marquardt algorithm [1, 2] as a tool for retrieval of properties of particles, suspended in the plane-parallel atmosphere coupled with the reflecting surface [3]. The effect of polarization of light is included. The Levenberg-Marquardt algorithm provides an iterative solution to the problem of minimization of a function over a space of its parameters. Each iteration involves solution of the forward problem and computation of the Jacobian matrix (the derivatives of signal over optical parameters). The recently developed code APC (Atmospheric Polarization Computations) is used to solve the forward problem [4, 5]. We use O.Dubovik's et al. [6] package to simulate scattering by spheroidal particles. Unlike for the purely spherical particles (Mie scattering), the Jacobian matrix for spheroids is computed numerically. We will consider retrievals over the land and the ocean with the bidirectional polarization distribution functions from [7-8]. Using MISR observation geometry and spectral bands [9] as an example, we will discuss the problem of convergence of iterations, sensitivity of the algorithm to the initial guess, the signal-to-noise ratio, and the geometry of observation. Possible ways of acceleration of iterations will be discussed, as well as the role of polarization in the retrieval process. References: 1. Levenberg K, Q. App. Math., 1944, V.2, P.164. 2. Marquardt D, J. Appl. Math., 1963, V.11, N.2, P.431. 3. Korkin S, Lyapustin A, AGU 2012, A23A-011. 4. Korkin S et al., JQSRT, 2013, V.127, P.1 5. ftp://climate1.gsfc.nasa.gov/skorkin/ 6. Dubovik O et al., Geophys. Res. Letters, 2006, V.111, D11208. 7. Ota Y, et al., JQSRT, 2010, V.111, P.878. 8. Nadal F, Breon F-M, IEEE Trans. Geos. Rem. Sens., 1999, V.37, N.3, P.1709. 9. http://www-misr.jpl.nasa.gov/Mission/misrInstrument/

  15. KELT-10b: The First Transiting Exoplanet from the KELT-South Survey - A Hot Sub-Jupiter Transiting a V=10.7 Early G-Star

    NASA Astrophysics Data System (ADS)

    Kuhn, Rudolf B.; Rodriguez, Joseph E.; Collins, Karen A.; Lund, Michael B.; Siverd, Robert J.; Colón, Knicole D.; Pepper, Joshua; Stassun, Keivan G.; Cargile, Phillip A.; James, David J.; Penev, Kaloyan; Zhou, George; Bayliss, Daniel; Tan, T. G.; Curtis, Ivan A.; Udry, Stephane; Segransan, Damien; Mawet, Dimitri; Dhital, Saurav; Soutter, Jack; Hart, Rhodes; Carter, Brad; Gaudi, B. Scott; Myers, Gordon; Beatty, Thomas G.; Eastman, Jason D.; Reichart, Daniel E.; Haislip, Joshua B.; Kielkopf, John; Bieryla, Allyson; Latham, David W.; Jensen, Eric L. N.; Oberst, Thomas E.; Stevens, Daniel J.

    2016-04-01

    We report the discovery of KELT-10b, the first transiting exoplanet discovered using the KELT-South telescope. KELT-10b is a highly inflated sub-Jupiter mass planet transiting a relatively bright V = 10.7 star (TYC 8378-64-1), with Teff = 5948 ± 74 K, log g = 4.319_{-0.030}^{+0.020} and [Fe/H] = 0.09_{-0.10}^{+0.11}, an inferred mass M★ = 1.112_{-0.061}^{+0.055} M⊙ and radius R★ = 1.209_{-0.035}^{+0.047} R⊙. The planet has a radius Rp = 1.399_{-0.049}^{+0.069} RJ and mass Mp = 0.679_{-0.038}^{+0.039} MJ. The planet has an eccentricity consistent with zero and a semi-major axis a = 0.05250_{-0.00097}^{+0.00086} AU. The best fitting linear ephemeris is T0 = 2457066.72045±0.00027 BJDTDB and P = 4.1662739±0.0000063 days. This planet joins a group of highly inflated transiting exoplanets with a radius larger and a mass less than that of Jupiter. The planet, which boasts deep transits of 1.4%, has a relatively high equilibrium temperature of Teq = 1377_{-23}^{+28} K, assuming zero albedo and perfect heat redistribution. KELT-10b receives an estimated insolation of 0.817_{-0.054}^{+0.068} × 109 erg s-1 cm-2, which places it far above the insolation threshold above which hot Jupiters exhibit increasing amounts of radius inflation. Evolutionary analysis of the host star suggests that KELT-10b may not survive beyond the current subgiant phase, depending on the rate of in-spiral of the planet over the next few Gyr. The planet transits a relatively bright star and exhibits the third largest transit depth of all transiting exoplanets with V < 11 in the southern hemisphere, making it a promising candidate for future atmospheric characterization studies.

  16. The Kepler-454 System: A Small, Not-rocky Inner Planet, a Jovian World, and a Distant Companion

    NASA Astrophysics Data System (ADS)

    Gettel, Sara; Charbonneau, David; Dressing, Courtney D.; Buchhave, Lars A.; Dumusque, Xavier; Vanderburg, Andrew; Bonomo, Aldo S.; Malavolta, Luca; Pepe, Francesco; Collier Cameron, Andrew; Latham, David W.; Udry, Stéphane; Marcy, Geoffrey W.; Isaacson, Howard; Howard, Andrew W.; Davies, Guy R.; Silva Aguirre, Victor; Kjeldsen, Hans; Bedding, Timothy R.; Lopez, Eric; Affer, Laura; Cosentino, Rosario; Figueira, Pedro; Fiorenzano, Aldo F. M.; Harutyunyan, Avet; Johnson, John Asher; Lopez-Morales, Mercedes; Lovis, Christophe; Mayor, Michel; Micela, Giusi; Molinari, Emilio; Motalebi, Fatemeh; Phillips, David F.; Piotto, Giampaolo; Queloz, Didier; Rice, Ken; Sasselov, Dimitar; Ségransan, Damien; Sozzetti, Alessandro; Watson, Chris; Basu, Sarbani; Campante, Tiago L.; Christensen-Dalsgaard, Jørgen; Kawaler, Steven D.; Metcalfe, Travis S.; Handberg, Rasmus; Lund, Mikkel N.; Lundkvist, Mia S.; Huber, Daniel; Chaplin, William J.

    2016-01-01

    Kepler-454 (KOI-273) is a relatively bright (V = 11.69 mag), Sun-like star that hosts a transiting planet candidate in a 10.6 day orbit. From spectroscopy, we estimate the stellar temperature to be 5687 ± 50 K, its metallicity to be [m/H] = 0.32 ± 0.08, and the projected rotational velocity to be v sin i < 2.4 km s-1. We combine these values with a study of the asteroseismic frequencies from short cadence Kepler data to estimate the stellar mass to be {1.028}-0.03+0.04{M}⊙ , the radius to be 1.066 ± 0.012 R⊙, and the age to be {5.25}-1.39+1.41 Gyr. We estimate the radius of the 10.6 day planet as 2.37 ± 0.13 R⊕. Using 63 radial velocity observations obtained with the HARPS-N spectrograph on the Telescopio Nazionale Galileo and 36 observations made with the HIRES spectrograph at the Keck Observatory, we measure the mass of this planet to be 6.8 ± 1.4 M⊕. We also detect two additional non-transiting companions, a planet with a minimum mass of 4.46 ± 0.12 MJ in a nearly circular 524 day orbit and a massive companion with a period >10 years and mass >12.1 MJ. The 12 exoplanets with radii <2.7 R⊕ and precise mass measurements appear to fall into two populations, with those <1.6 R⊕ following an Earth-like composition curve and larger planets requiring a significant fraction of volatiles. With a density of 2.76 ± 0.73 g cm-3, Kepler-454b lies near the mass transition between these two populations and requires the presence of volatiles and/or H/He gas.

  17. Lasso peptide, a highly stable structure and designable multifunctional backbone.

    PubMed

    Zhao, Ning; Pan, Yongxu; Cheng, Zhen; Liu, Hongguang

    2016-06-01

    Lasso peptide belongs to a new class of natural product with highly compact and stable structure. It has varieties of biological activities, among which the most important one is its antibacterial efficacy. Novel lasso peptides have been constantly discovered and analyzed by advanced techniques, and the biosynthesis or even chemical synthesis of lasso peptide has been studied after learning its constituent amino acids and maturation process. Structural identification of lasso peptide provides information for elucidating the mechanisms of its antibacterial activity and basis for further modifications. Ring of lasso peptide is the key to both its highly compact and stable structure and its intrinsic antibacterial property. The loop has been considered as suitable modification region of lasso peptide, such as V11-S18 of MccJ25 being modifiable without disrupting the lasso structure in biosynthesis. The tail is the immunity protein that can export lasso peptide out of its produced strain and serve as a self-protection mechanism at the same time. Most of currently known lasso peptides are non-pathogenic, which implies that the modified lasso peptides are promising candidates for medical applications. Arginine, glycine, and aspartic acid as a ligands of cancer-specific receptor have been grafted to the loop of lasso peptide without losing its bioactivity, and many other targets are expected to be used for lasso peptide modification. Multi-molecular modification and large-scale production need to be studied and solved in future for designing and using multifunctional lasso peptide based on its extraordinary stable structure. PMID:27074719

  18. Is rheumatoid arthritis in Indians associated with HLA antigens sharing a DR beta 1 epitope?

    PubMed Central

    Ollier, W E; Stephens, C; Awad, J; Carthy, D; Gupta, A; Perry, D; Jawad, A; Festenstein, H

    1991-01-01

    HLA class II antigens were identified in a group of 44 patients with rheumatoid arthritis (RA) originating largely from the north or northeast of the Indian subcontinent and resident now in east London. Compared with 67 locally typed east London Asian controls, the prevalence of three HLA-DR antigens was raised in the patients: DR1 18.2% v 6.0% chi 2 = 3.99, DR4 20.5% v 11.9% chi 2 = 1.48, and DRw10 27.3% v 8.9% chi 2 = 6.56. These differences were also found when the patients with RA were compared with a larger control group of 110 northern Indians: DR1 18.2% v 7.2% chi 2 = 4.02, DR4 20.5% v 7.2% chi 2 = 5.56, and DRw10 27.3% v 8.1% chi 2 = 9.7. Twenty five (57%) of the patients expressed at least one of these antigens. All patients were also characterised for HLA-Dw types by mixed lymphocyte culture typing. The prevalence of the HLA-DR4 associated Dw types in the patients was: Dw4 2.3%, Dw10 0%, Dw14 11.4%, and Dw15 6.8%. The DR beta 1 chains of DR1 and DRw10 together with the Dw types of DR4 other than Dw10 share amino acid residues in a region of the third hypervariable region considered to be critical in antigen presentation. It is concluded that RA in Indians is associated with these HLA antigens, and data from this study support the hypothesis of a cross reactive epitope common to HLA specificities associated with RA. PMID:1710441

  19. Multisensensor Multitemporal Data Fusion Using Wavelet Transform

    NASA Astrophysics Data System (ADS)

    Ghannam, S.; Awadallah, M.; Abbott, A. L.; Wynne, R. H.

    2014-11-01

    Interest in data fusion, for remote-sensing applications, continues to grow due to the increasing importance of obtaining data in high resolution both spatially and temporally. Applications that will benefit from data fusion include ecosystem disturbance and recovery assessment, ecological forecasting, and others. This paper introduces a novel spatiotemporal fusion approach, the wavelet-based Spatiotemporal Adaptive Data Fusion Model (WSAD-FM). This new technique is motivated by the popular STARFM tool, which utilizes lower-resolution MODIS imagery to supplement Landsat scenes using a linear model. The novelty of WSAD-FM is twofold. First, unlike STARFM, this technique does not predict an entire new image in one linear step, but instead decomposes input images into separate "approximation" and "detail" parts. The different portions are fed into a prediction model that limits the effects of linear interpolation among images. Low-spatial-frequency components are predicted by a weighted mixture of MODIS images and low-spatial-frequency components of Landsat images that are neighbors in the temporal domain. Meanwhile, high-spatialfrequency components are predicted by a weighted average of high-spatial-frequency components of Landsat images alone. The second novelty is that the method has demonstrated good performance using only one input Landsat image and a pair of MODIS images. The technique has been tested using several Landsat and MODIS images for a study area from Central North Carolina (WRS-2 path/row 16/35 in Landsat and H/V11/5 in MODIS), acquired in 2001. NDVI images that were calculated from the study area were used as input to the algorithm. The technique was tested experimentally by predicting existing Landsat images, and we obtained R2 values in the range 0.70 to 0.92 for estimated Landsat images in the red band, and 0.62 to 0.89 for estimated NDVI images.

  20. Effect of human papillomavirus vaccination on cervical cancer screening in Alberta

    PubMed Central

    Kim, Jong; Bell, Christopher; Sun, Maggie; Kliewer, Gordon; Xu, Linan; McInerney, Maria; Svenson, Lawrence W.; Yang, Huiming

    2016-01-01

    Background: A school-based program with quadrivalent human papillomavirus (HPV) vaccination was implemented in Alberta in 2008. We assessed the impact of this program on Pap test cytology results using databases of province-wide vaccination and cervical cancer screening. Methods: We conducted a nested case–control study involving a cohort of women in Alberta born between 1994 and 1997 who had at least 1 Pap test between 2012 and 2015. Women with negative cytology results were controls. Women with low-grade (atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion) and high-grade (atypical squamous cells, cannot rule out a high-grade lesion; or high-grade squamous intraepithelial lesion) cervical abnormalities were cases. Exposure status was assigned according to records of HPV vaccination. Odds ratios (ORs) for abnormal cytology results by vaccination status were adjusted for neighbourhood income, laboratory service, rural versus urban residency, and age. Results: The total study population was 10 204. Adjusting for age, vaccinated women had a higher screening rate than unvaccinated women (13.0% v. 11.4%, p < 0.001). Among women who received full vaccination (≥ 3 doses), the adjusted OR for cervical abnormalities was 0.72 (95% confidence interval [CI] 0.63–0.82). For high-grade lesions, the adjusted OR was 0.50 (95% CI 0.30–0.85). With 2-dose HPV vaccination, the adjusted OR for cervical abnormalities was 1.08 (95% CI 0.84–1.38). Interpretation: Quadrivalent HPV vaccination significantly reduced high-grade cervical abnormalities but required 3 doses. Vaccination against HPV was associated with screening uptake. Population-based vaccination and screening programs should work together to optimize cervical cancer prevention. PMID:27378467

  1. Superhumps in Cataclysmic Binaries. XV. EG Cancri, King of the Echo Outbursts

    NASA Astrophysics Data System (ADS)

    Patterson, Joseph; Kemp, Jonathan; Skillman, David R.; Harvey, David A.; Shafter, Allen W.; Vanmunster, Tonny; Jensen, Lasse; Fried, Robert; Kiyota, Seiichiro; Thorstensen, John R.; Taylor, Cynthia J.

    1998-11-01

    We report photometry and spectroscopy of the dwarf nova EG Cancri in its 1996/1997 episode of eruptions. The main eruption was clearly a superoutburst featuring common superhumps with a period of 0.06036(2) days, establishing the star as a new member of the SU UMa class of dwarf novae. At the end of the main eruption, the superhumps were replaced by another wave of slightly longer period (0.06045 days), which endured for at least another 90 days. The properties of the latter wave suggest identification as a ``late superhump.'' The recurrence time for superoutbursts is long, probably in the range 7-20 yr. After the 15 day superoutburst, the star displayed six remarkable surges in light, with an average interval of 7 days; these ``echo outbursts'' strongly resemble ordinary dwarf nova eruptions. This suggests that a high accretion rate persisted in the disk for ~40 days after the main superoutburst. By a year after outburst, the star faded to V=18.7, with most of the continuum light from a white dwarf of T~15,000 K. We estimate a distance of 320 pc and a v>=+11.5 for accretion light. The extreme faintness, the rarity of eruptions, the enormous duration of superhumps, and the quiescent spectrum together establish membership in the WZ Sge subclass, the most sluggish of dwarf novae. Spectroscopy at quiescence and a transient wave in early outburst establish an orbital period of 0.05997(9) days. This suggests a secondary star with M~0.02 M_solar, yet R~0.08 R_solar. A binary can reach such a state after the secondary is forced to lose mass on a timescale shorter than its Kelvin-Helmholtz timescale.

  2. The Type-Ia Supernova 1998bu in M96 and the Hubble Constant

    NASA Astrophysics Data System (ADS)

    Jha, S.; Garnavich, P. M.; Challis, P. M.; Kirshner, R. P.; Riess, A. G.; Filippenko, A. V.; Li, W.; Modjaz, M.; Treffers, R. R.; Grebel, E. K.; Seitzer, P.; Jacoby, G. H.; Benson, P. J.; Rizvi, A.; Marschall, L. A.

    1998-12-01

    We present extensive early-time photometric and spectroscopic observations of the type-Ia SN 1998bu in the Leo I Group galaxy M96 (NGC 3368). The well-sampled optical light curves consist of 311 UBVRI observations obtained from several telescopes: the F. L. Whipple Observatory 1.2-m, the MDM Observatory 2.4-m, the WIYN Observatory 3.5-m, the Kitt Peak National Observatory 0.9-m, the Whitin Observatory 0.6-m at Wellesley College, the Gettysburg College Observatory 0.4-m and the 0.76-m Katzman Automatic Imaging Telescope operated by UC Berkeley. The supernova reached maximum brightness in the B band on JD 2450952.8 +/- 0.8, with B = 12.22 +/- 0.03 and V = 11.88 +/- 0.02. There is strong evidence for considerable interstellar extinction along the line of sight to the supernova, but the light curve is otherwise quite typical of type-Ia supernovae (SNe Ia). The distance to M96 has been measured via HST observations of Cepheids in the galaxy (Tanvir et al. 1995), making SN 1998bu very useful in determining the absolute luminosity of SNe Ia. We combine these observations with those of other Cepheid-calibrated SNe Ia and SNe Ia in the Hubble flow and perform a Multicolor Light Curve Shape analysis to derive a Hubble Constant of 64 +/- 4 km/s/Mpc (internal error), but subject to several sources of systematic uncertainty in the Cepheid distance scale.

  3. Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

    PubMed Central

    2010-01-01

    Introduction Osteoporosis (OP) increases cartilage damage in a combined rabbit model of OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at subchondral bone aggravates cartilage damage in this experimental model. Methods OP was induced in 20 female rabbits, by ovariectomy and intramuscular injections of methylprednisolone hemisuccinate for four weeks. Ten healthy animals were used as controls. At week 7, OA was surgically induced in left knees of all rabbits. At 22 weeks, after sacrifice, microstructure parameters were assessed by micro-computed tomography, and osteoprotegerin (OPG), receptor activator of nuclear factor-κB ligand (RANKL), alkaline phosphatase (ALP) and metalloproteinase 9 (MMP9) protein expressions were evaluated by Western Blot at subchondral bone. In addition, cartilage damage was estimated using the histopathological Mankin score. Mann-Whitney and Spearman statistical tests were performed as appropriate, using SPSS software v 11.0. Significant difference was established at P < 0.05. Results Subchondral bone area/tissue area, trabecular thickness and polar moment of inertia were diminished in OPOA knees compared with control or OA knees (P < 0.05). A decrease of plate thickness, ALP expression and OPG/RANKL ratio as well as an increased fractal dimension and MMP9 expression occurred at subchondral bone of OA, OP and OPOA knees vs. controls (P < 0.05). In addition, the severity of cartilage damage was increased in OPOA knees vs. controls (P < 0.05). Remarkably, good correlations were observed between structural and remodelling parameters at subchondral bone, and furthermore, between subchondral structural parameters and cartilage Mankin score. Conclusions Microstructure impairment at subchondral bone associated with an increased remodelling aggravated cartilage damage in OA rabbits with previous OP. Our results suggest that an increased subchondral bone resorption may account for the exacerbation of cartilage

  4. [Value of early acoustic and somatosensory evoked potentials in monitoring and prognostic assessment of coma in barbiturate therapy--comparison with clinical aspects and EEG].

    PubMed

    Reisecker, F; Witzmann, A; Löffler, W; Leblhuber, F; Deisenhammer, E; Valencak, E

    1987-03-01

    25 comatose patients suffering from severe cerebral lesions of different etiology were examined during barbiturate-therapy by Glasgow-Pittsburg-Coma-Scoring-System (GPCS), EEG, somatosensory and brainstem acoustic evoked potentials. The findings were correlated in view of prognostic prediction and importance for monitoring. A modified form of the Glasgow-Outcome-Score (GOS; independent-survival, dependent-survival, dead) was used for evaluating the outcome. In case of an initial GPCS less than 10 points none of the patients survived, in case of GPCS greater than 10 points 11 out of 19 patients survived. The latter relation of survival was also found in patients with improving or impairing scores during the observation period. In case of initial burst-suppression pattern in the EEG 7 out of 11 patients survived, in case of diffuse abnormalities with or with-out additional focal signs - 4 out of 10 patients survived, but in the latter there was none with an outcome of independent survival. All patients with an isoelectric EEG died. In case of bilateral recording of scalp- SEP 7 out of 11 patients survived, in case of unilateral loss of scalp-EP 4 out of 8 patients survived, but in the latter cases none with an outcome of independence. All patients with initial bilateral failure of scalp-SSEP or loss during the observation period died. In case of bilateral registrable BAEP (wave I to V) 11 out of 17 patients survived. All patients with initial uni- or bilateral failure of those potentials or loss during the observation period died.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3106004

  5. First Detection in Gamma-Rays of a Young Radio Galaxy: Fermi-LAT Observations of the Compact Symmetric Object PKS 1718-649

    NASA Astrophysics Data System (ADS)

    Migliori, G.; Siemiginowska, A.; Sobolewska, M.; Loh, A.; Corbel, S.; Ostorero, L.; Stawarz, Ł.

    2016-04-01

    We report the γ-ray detection of a young radio galaxy, PKS 1718-649, belonging to the class of compact symmetric objects (CSOs), with the Large Area Telescope (LAT) on board the Fermi satellite. The third Fermi Gamma-ray LAT catalog (3FGL) includes an unassociated γ-ray source, 3FGL J1728.0-6446, located close to PKS 1718-649. Using the latest Pass 8 calibration, we confirm that the best-fit 1σ position of the γ-ray source is compatible with the radio location of PKS 1718-649. Cross-matching of the γ-ray source position with the positions of blazar sources from several catalogs yields negative results. Thus, we conclude that PKS 1718-649 is the most likely counterpart to the unassociated LAT source. We obtain a detection test statistics TS ˜ 36 (>5σ) with a best-fit photon spectral index Γ = 2.9 ± 0.3 and a 0.1-100 GeV photon flux density F 0.1-100 GeV = (11.5 ± 0.3) × 10-9 ph cm-2 s-1. We argue that the linear size (˜2 pc), the kinematic age (˜100 years), and the source distance (z = 0.014) make PKS 1718-649 an ideal candidate for γ-ray detection in the framework of the model proposing that the most compact and the youngest CSOs can efficiently produce GeV radiation via inverse-Compton scattering of the ambient photon fields by the radio lobe non-thermal electrons. Thus, our detection of the source in γ-rays establishes young radio galaxies as a distinct class of extragalactic high-energy emitters and yields a unique insight on the physical conditions in compact radio lobes interacting with the interstellar medium of the host galaxy.

  6. Deformable image registration for geometrical evaluation of DIBH radiotherapy treatment of lung cancer patients

    NASA Astrophysics Data System (ADS)

    Ottosson, W.; Lykkegaard Andersen, J. A.; Borrisova, S.; Mellemgaard, A.; Behrens, C. F.

    2014-03-01

    Respiration and anatomical variation during radiotherapy (RT) of lung cancer yield dosimetric uncertainties of the delivered dose, possibly affecting the clinical outcome if not corrected for. Adaptive radiotherapy (ART), based on deformable image registration (DIR) and Deep-Inspiration-Breath-Hold (DIBH) gating can potentially improve the accuracy of RT. Purpose: The objective was to investigate the performance of contour propagation on repeated CT and Cone Beam CT (CBCT) images in DIBH compared to images acquired in free breathing (FB), using a recently released DIR software. Method: Three locally advanced non-small cell lung cancer patients were included, each with a planning-, midterm- and final CT (pCT, mCT, fCT) and 7 CBCTs acquired weekly and on the same day as the mCT and fCT. All imaging were performed in both FB and DIBH, using Varian RPM system for respiratory tracking. Delineations of anatomical structures were performed on each image set. The CT images were retrospective rigidly and deformable registered to all obtained images using the Varian Smart Adapt v. 11.0. The registered images were analysed for volume change and Dice Similarity Coefficient (DSC). Result: Geometrical similarities were found between propagated and manually delineated structures, with a slightly favour of FB imaging. Special notice should be taken to registrations where image artefacts or low tissue contrast are present. Conclusion: This study does not support the hypothesis that DIBH images perform better image registration than FB images. However DIR is a feasible tool for ART of lung cancer.

  7. TRENDS IN DENTAL VISITS AMONG THE US NON-INSTITUTIONALIZED CIVILIAN POPULATION: FINDINGS FROM BRFSS 1995 – 2008

    PubMed Central

    Lucas-Perry, Evelyn

    2013-01-01

    Objective To examine the 13-year trend in annual dental care utilization among the US non-institutionalized civilian population. Methods Data from the BRFSS from 1995–2008 for adults’ age 18 and older were abstracted and analyzed using the NIDCR/CDC data query system. Point-estimates, confidence-intervals, trends and differences in trends for self-reported annual dental visits by socio-demographic factors and behavioral factor (smoking) were tested with chi-square tests using Stata® (v11). Results The overall, median percent of reported dental visits increased marginally (1.3%; p=0.99) from 68.6% (66.2%, 70.9%) in 1995 to 69.9% (69.1%, 71.7%) in 2008. Trend lines remained flat for most age groups except for those aged 65 and older, which showed a steady rise from 58.9% (52.9%, 64.9%) in 1995 to 66.3% (63.9%, 68.7%) in 2008. Disparities in median annual dental visits between non-Hispanic whites and other racial/ethnic groups increased from a range of a 2–7% point difference (1995) to a 7–11% point difference (2008). A higher percentage of women relative to men reported a visit 70.1% (66.9%, 73.2%) vs. 66.6 % (63.8%, 69.3%) in 1995 and 71.2% (69.2%, 73.2%) vs. 67.4% (65.0%, 69.7%) in 2008; trends and differences in trends among gender remained similar over time (4–5%). No meaningful change in reported dental visit by race/ethnicity; income, education or smoking was seen. Conclusion Over 13 years, the proportion of persons visiting a dentist has remained relatively constant. Of note is that disparities in dental visits by socio-demographic factors also remained the same over time. PMID:24416728

  8. The Young and Bright Type Ia Supernova ASASSN-14lp: Discovery, Early-time Observations, First-light Time, Distance to NGC 4666, and Progenitor Constraints

    NASA Astrophysics Data System (ADS)

    Shappee, B. J.; Piro, A. L.; Holoien, T. W.-S.; Prieto, J. L.; Contreras, C.; Itagaki, K.; Burns, C. R.; Kochanek, C. S.; Stanek, K. Z.; Alper, E.; Basu, U.; Beacom, J. F.; Bersier, D.; Brimacombe, J.; Conseil, E.; Danilet, A. B.; Dong, Subo; Falco, E.; Grupe, D.; Hsiao, E. Y.; Kiyota, S.; Morrell, N.; Nicolas, J.; Phillips, M. M.; Pojmanski, G.; Simonian, G.; Stritzinger, M.; Szczygieł, D. M.; Taddia, F.; Thompson, T. A.; Thorstensen, J.; Wagner, M. R.; Woźniak, P. R.

    2016-08-01

    On 2014 December 9.61, the All-sky Automated Survey for SuperNovae (ASAS-SN or “Assassin”) discovered ASASSN-14lp just ∼2 days after first light using a global array of 14 cm diameter telescopes. ASASSN-14lp went on to become a bright supernova (V = 11.94 mag), second only to SN 2014J for the year. We present prediscovery photometry (with a detection less than a day after first light) and ultraviolet through near-infrared photometric and spectroscopic data covering the rise and fall of ASASSN-14lp for more than 100 days. We find that ASASSN-14lp had a broad light curve ({{Δ }}{m}15(B)=0.80+/- 0.05), a B-band maximum at 2457015.82 ± 0.03, a rise time of {16.94}-0.10+0.11 days, and moderate host-galaxy extinction (E{(B-V)}{host}=0.33+/- 0.06). Using ASASSN-14lp, we derive a distance modulus for NGC 4666 of μ =30.8+/- 0.2, corresponding to a distance of 14.7 ± 1.5 Mpc. However, adding ASASSN-14lp to the calibrating sample of Type Ia supernovae still requires an independent distance to the host galaxy. Finally, using our early-time photometric and spectroscopic observations, we rule out red giant secondaries and, assuming a favorable viewing angle and explosion time, any nondegenerate companion larger than 0.34 {R}ȯ .

  9. The Young and Bright Type Ia Supernova ASASSN-14lp: Discovery, Early-time Observations, First-light Time, Distance to NGC 4666, and Progenitor Constraints

    NASA Astrophysics Data System (ADS)

    Shappee, B. J.; Piro, A. L.; Holoien, T. W.-S.; Prieto, J. L.; Contreras, C.; Itagaki, K.; Burns, C. R.; Kochanek, C. S.; Stanek, K. Z.; Alper, E.; Basu, U.; Beacom, J. F.; Bersier, D.; Brimacombe, J.; Conseil, E.; Danilet, A. B.; Dong, Subo; Falco, E.; Grupe, D.; Hsiao, E. Y.; Kiyota, S.; Morrell, N.; Nicolas, J.; Phillips, M. M.; Pojmanski, G.; Simonian, G.; Stritzinger, M.; Szczygieł, D. M.; Taddia, F.; Thompson, T. A.; Thorstensen, J.; Wagner, M. R.; Woźniak, P. R.

    2016-08-01

    On 2014 December 9.61, the All-sky Automated Survey for SuperNovae (ASAS-SN or “Assassin”) discovered ASASSN-14lp just ˜2 days after first light using a global array of 14 cm diameter telescopes. ASASSN-14lp went on to become a bright supernova (V = 11.94 mag), second only to SN 2014J for the year. We present prediscovery photometry (with a detection less than a day after first light) and ultraviolet through near-infrared photometric and spectroscopic data covering the rise and fall of ASASSN-14lp for more than 100 days. We find that ASASSN-14lp had a broad light curve ({{Δ }}{m}15(B)=0.80+/- 0.05), a B-band maximum at 2457015.82 ± 0.03, a rise time of {16.94}-0.10+0.11 days, and moderate host-galaxy extinction (E{(B-V)}{host}=0.33+/- 0.06). Using ASASSN-14lp, we derive a distance modulus for NGC 4666 of μ =30.8+/- 0.2, corresponding to a distance of 14.7 ± 1.5 Mpc. However, adding ASASSN-14lp to the calibrating sample of Type Ia supernovae still requires an independent distance to the host galaxy. Finally, using our early-time photometric and spectroscopic observations, we rule out red giant secondaries and, assuming a favorable viewing angle and explosion time, any nondegenerate companion larger than 0.34 {R}ȯ .

  10. Measuring equity in household's health care payments (Tehran-Iran 2013): technical points for health policy decision makers

    PubMed Central

    Rezapour, Aziz; Ebadifard Azar, Farbod; Azami Aghdash, Saber; Tanoomand, Asghar; Hosseini Shokouh, Seyed Morteza; Yousefzadeh, Negar; Atefi Manesh, Pezhman; Sarabi Asiabar, Ali

    2015-01-01

    Background: Households’ financial protection against health payments and expenditures and equity in utilization of health care services are of the most important tasks of governments. This study aims to measuring equity in household’s health care payments according to fairness in financial contribution (FFC) and Kakwani indices in Tehran-Iran, 2013. Methods: This cross-sectional study was conducted in 2014.The study sample size was estimated to be 2200 households. Households were selected using stratified-cluster sampling including typical families who reside in the city of Tehran. The data were analyzed through Excel and Stata v.11software. Recall period for the inpatient care was 1 year and for outpatient1 month. Results: The indicator of FFC for households in health financing was estimated to be 0.68 and the trend of the indicator was ascending by the rise in the ranking of households’ financial level. The Kakwani index was estimated to be a negative number (-0.00125) which indicated the descending trend of health financing system. By redistribution of incomes or the exempt of the poorest quintiles from health payments, Kakwani index was estimated to be a positive number (0.090555) which indicated the ascending trend of health financing system. Conclusion: According to this study, the equity indices in health care financing denote injustice and a descending trend in the health care financing system. This finding clearly shows that deliberate policy making in health financing by national health authorities and protecting low-income households against health expenditures are required to improve the equity in health. PMID:26793637

  11. Inequity in household's capacity to pay and health payments in Tehran-Iran-2013

    PubMed Central

    Rezapour, Aziz; Ebadifard Azar, Farbod; Azami Aghdash, Saber; Tanoomand, Asghar; Ahmadzadeh, Nahal; Sarabi Asiabar, Ali

    2015-01-01

    Background: Health inequality monitoring especially in Health care financing field is very important. Hence, this study tends to assess the inequality in household's capacity to pay and out-of-pocket health carepaymentsin Tehran metropolis. Methods: This cross-sectional study was performed in 2013.Thestudy population was selected by stratified cluster sampling, and they constitute the typical households living in Tehran (2200 households). The required data were collected through questionnaires and analyzed using Excel and Stata v.11. Concentration Index on inequality was used for measuring inequality status in capacity to pay and household payments for health care expenses; and also the concentration index for out-of-pocket payments and capacity to pay was used to determine the extent of inequality. The recall period for inpatient care was one year and 1 month for outpatient. Results: The average of out-of-pocket payments for receiving the outpatient services was determined to be 44.33US$ and for each inpatient1861.11 US$. Concentration index for household's outof- pocket payments for inpatient health care, out-of-pocket payments for outpatient health care and health prepayments were calculated 0.13, -0.10 and -0.11, respectively. Also, concentration index in household’s capacity to pay was estimated to be 0.11whichindicatedinequality to the benefit of the rich. The households used financing strategies like savings, borrowing or lending to pay their health care expenditures. Conclusion: According to this study, the poor spend a greater portion of their capacity to pay for outpatient and inpatient health care costs and prepayment, in comparison to the rich. Thus, supporting the vulnerable groups of the society to decrease out-of-pocket payments and increasing the household’s capacity to pay through government support in order to improve the household economic potential, must be considered very important. PMID:26793636

  12. The Death Spiral of T Pyxidis

    NASA Astrophysics Data System (ADS)

    Patterson, J.; Oksanen, A.; Monard, B.; Rea, R.; Hambsch, F.; McCormick, J.; Nelson, P.; Kemp, J.; Allen, W.; Krajci, T.; Lowther, S.; Dvorak, S.; Richards, T.; Myers, G.; Bolt, G.

    2014-12-01

    We report a long campaign to track the 1.8 hr photometric wave in the recurrent nova T Pyxidis, using the global telescope network of the Center for Backyard Astrophysics. During 1996-2011, that wave was highly stable in amplitude and waveform, resembling the orbital wave commonly seen in supersoft binaries. The period, however, was found to increase on a timescale P/P =3 ×105 yr. This suggests a mass transfer rate of ˜ 10-7 M⊙/yr in quiescence. The orbital signal became vanishingly weak (< 0.003 mag) near maximum light of the 2011 eruption. After it returned to visibility near V=11, the orbital period had increased by 0.0054(6) %. This is a measure of the mass ejected in the nova outburst. For a plausible choice of binary parameters, that mass is at least 3×10-5 M⊙, and probably more. This represents > 300 yr of accretion at the pre-outburst rate, but the time between outbursts was only 45 yr. Thus the erupting white dwarf seems to have ejected at least 6 × more mass than it accreted. If this eruption is typical, the white dwarf must be eroding, rather than growing, in mass — dashing the star's hopes of ever becoming famous via a supernova explosion. Instead, it seems likely that the binary dynamics are basically a suicide pact between the eroding white dwarf and the low-mass secondary, excited and rapidly whittled down, probably by the white dwarf's EUV radiation.

  13. High-Resolution Infrared Spectra of Bicyclo[1.1.1]pentane

    SciTech Connect

    Martin, Matthew A.; Perry, Adam J.; Masiello, Tony; Schwartz, Keith D.; Nibler, Joseph W.; Weber, Alfons; Maki, Arthur; Blake, Thomas A.

    2010-07-01

    Infrared spectra of bicyclo[1.1.1]pentane (C5H8) have been recorded at a resolution (0.0015 cm-1) sufficient to resolve for the first time individual rovibrational lines. This initial report presents the ground state constants for this molecule determined from the detailed analysis of three of the ten infrared-allowed bands, v14(e′) at 540 cm-1, v17(a2″) at 1220 cm-1, v18(a2″) at 832 cm-1, and a partial analysis of the v11(e′) band at 1237 cm-1. The upper states of transitions involving the lowest frequency mode, v14(e′), show no evidence of rovibrational perturbations but those for the v17 and v18 (a2″) modes give clear indication of Coriolis coupling to nearby e′ levels. Accordingly, ground state constants were determined by use of the combination-difference method for all three bands. The assigned frequencies provided over 3300 consistent ground state difference values, yielding the following constants for the ground state (in units of cm-1): B0 = 0.2399412(2), DJ = 6.024(6) x 10-8, DJK = -1.930(21) x 10-8. For the unperturbed v14(e′) fundamental, more than 3500 transitions were analyzed and the band origin was found to be at 540.34225(2) cm-1. The numbers in parentheses are the uncertainties (two standard deviations) in the values of the constants. The results are compared with those obtained previously for [1.1.1]propellane and with those computed at the ab initio anharmonic level using the B3LYP density functional method with a cc-pVTZ basis set.

  14. Transversal and longitudinal mode selections in double-corrugation coaxial slow-wave devices

    SciTech Connect

    Ge Xingjun; Zhong Huihuang; Qian Baoliang; Liu Lie; Liu Yonggui; Li Limin; Shu Ting; Zhang Jiande

    2009-06-15

    To reduce the dimensions of relativistic backward wave oscillators (RBWOs) operating in the low frequency regime of less than 2 GHz, the theory of transversal and longitudinal mode selections are introduced in this paper. The transversal mode selection is achieved using the property of ''surface wave'' of the coaxial slow-wave structure (SWS) to excite the quasi transverse electromagnetic (quasi-TEM) mode without the higher transverse magnetic (TM) modes and it is proved that the coaxial SWS may decrease the transversal dimension of the SWS sections. In addition, the S-parameter method is employed to investigate the longitudinal resonant characteristic of the finite-length SWS, and the scheme of longitudinal mode selection is put forward. It is proposed that the introduction of a well-designed coaxial extractor to slow-wave devices can help to achieve the longitudinal mode selection and reduce the period number of the SWS, which not only can make the devices more compact, but also can avoid the destructive competition between various longitudinal modes, therefore can enhance the efficiency and stabilize the frequency. To sum up, the physical mechanisms of transversal and longitudinal mode selections ensure that the microwave is produced with a single mode and a narrow band. Based on the above discussion, a compact L-band coaxial RBWO is investigated and optimized in detail with the particle-in-cell KARAT code (V. P. Tarakanov, Berkeley Research Associates, Inc., 1992). In simulation, the L-band coaxial RBWO, driven by a 700 kV, 11 kA electron beam, comes to a nonlinear steady state in 20 ns. High-power microwave of quasi-TEM mode is generated with an average power of 2.66 GW, a frequency of 1.6 GHz, and power conversion efficiency of 34.5% in durations of 30-60 ns.

  15. THRESHING IN ACTION: THE TIDAL DISRUPTION OF A DWARF GALAXY BY THE HYDRA I CLUSTER

    SciTech Connect

    Koch, Andreas; Burkert, Andreas; Rich, R. Michael; Black, Christine S.; Collins, Michelle L. M.; Hilker, Michael; Benson, Andrew J.

    2012-08-10

    We report on the discovery of strong tidal features around a dwarf spheroidal galaxy in the Hydra I galaxy cluster, indicating its ongoing tidal disruption. This very low surface brightness object, HCC-087, was originally classified as an early-type dwarf in the Hydra Cluster Catalogue (HCC), but our re-analysis of the ESO-VLT/FORS images of the HCC unearthed a clear indication of an S-shaped morphology and a large spatial extent. Its shape, luminosity (M{sub V} = -11.6 mag), and physical size (at a half-light radius of 3.1 kpc and a full length of {approx}5.9 kpc) are comparable to the recently discovered NGC 4449B and the Sagittarius dwarf spheroidal, all of which are undergoing clear tidal disruption. Aided by N-body simulations we argue that HCC-087 is currently at its first apocenter, at 150 kpc, around the cluster center and that it is being tidally disrupted by the galaxy cluster's potential itself. An interaction with the nearby (50 kpc) S0 cluster galaxy HCC-005, at M{sub *} {approx} 3 Multiplication-Sign 10{sup 10} M{sub Sun} is rather unlikely, as this constellation requires a significant amount of dynamical friction and thus low relative velocities. The S-shaped morphology and large spatial extent of the satellite would, however, also appear if HCC-087 would orbit the cluster center. These features appear to be characteristic properties of satellites that are seen in the process of being tidally disrupted, independent of the environment of the destruction. An important finding of our simulations is an orientation of the tidal tails perpendicular to the orbit.

  16. Automatic detection of cardiovascular risk in CT attenuation correction maps in Rb-82 PET/CTs

    NASA Astrophysics Data System (ADS)

    Išgum, Ivana; de Vos, Bob D.; Wolterink, Jelmer M.; Dey, Damini; Berman, Daniel S.; Rubeaux, Mathieu; Leiner, Tim; Slomka, Piotr J.

    2016-03-01

    CT attenuation correction (CTAC) images acquired with PET/CT visualize coronary artery calcium (CAC) and enable CAC quantification. CAC scores acquired with CTAC have been suggested as a marker of cardiovascular disease (CVD). In this work, an algorithm previously developed for automatic CAC scoring in dedicated cardiac CT was applied to automatic CAC detection in CTAC. The study included 134 consecutive patients undergoing 82-Rb PET/CT. Low-dose rest CTAC scans were acquired (100 kV, 11 mAs, 1.4mm×1.4mm×3mm voxel size). An experienced observer defined the reference standard with the clinically used intensity level threshold for calcium identification (130 HU). Five scans were removed from analysis due to artifacts. The algorithm extracted potential CAC by intensity-based thresholding and 3D connected component labeling. Each candidate was described by location, size, shape and intensity features. An ensemble of extremely randomized decision trees was used to identify CAC. The data set was randomly divided into training and test sets. Automatically identified CAC was quantified using volume and Agatston scores. In 33 test scans, the system detected on average 469mm3/730mm3 (64%) of CAC with 36mm3 false positive volume per scan. The intraclass correlation coefficient for volume scores was 0.84. Each patient was assigned to one of four CVD risk categories based on the Agatston score (0-10, 11-100, 101-400, <400). The correct CVD category was assigned to 85% of patients (Cohen's linearly weighted κ0.82). Automatic detection of CVD risk based on CAC scoring in rest CTAC images is feasible. This may enable large scale studies evaluating clinical value of CAC scoring in CTAC data.

  17. Five transiting hot Jupiters discovered using WASP-South, Euler, and TRAPPIST: WASP-119 b, WASP-124 b, WASP-126 b, WASP-129 b, and WASP-133 b

    NASA Astrophysics Data System (ADS)

    Maxted, P. F. L.; Anderson, D. R.; Collier Cameron, A.; Delrez, L.; Gillon, M.; Hellier, C.; Jehin, E.; Lendl, M.; Neveu-VanMalle, M.; Pepe, F.; Pollacco, D.; Queloz, D.; Ségransan, D.; Smalley, B.; Smith, A. M. S.; Southworth, J.; Triaud, A. H. M. J.; Udry, S.; Wagg, T.; West, R. G.

    2016-06-01

    We have used photometry from the WASP-South instrument to identify 5 stars showing planet-like transits in their light curves. The planetary nature of the companions to these stars has been confirmed using photometry from the EulerCam instrument on the Swiss Euler 1.2-m telescope and the TRAPPIST telescope, and spectroscopy obtained with the CORALIE spectrograph. The planets discovered are hot Jupiter systems with orbital periods in the range 2.17 to 5.75 days, masses from 0.3 MJup to 1.2 MJup and with radii from 1 RJup to 1.5 RJup. These planets orbit bright stars (V = 11-13) with spectral types in the range F9 to G4. WASP-126 is the brightest planetary system in this sample and hosts a low-mass planet with a large radius (0.3 MJup,0.95 RJup), making it a good target for transmission spectroscopy. The high density of WASP-129 A suggests that it is a helium-rich star similar to HAT-P-11 A. WASP-133 A has an enhanced surface lithium abundance compared to other old G-type stars, particularly other planet host stars. These planetary systems are good targets for follow-up observations with ground-based and space-based facilities to study their atmospheric and dynamical properties. Full Tables 2 and 3 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/591/A55

  18. Outburst evolution, historic light curve and a flash-ionized nebula around the WZ Sge-type object PNV J03093063+2638031

    NASA Astrophysics Data System (ADS)

    Munari, U.; Jurdana-Šepić, R.; Ochner, P.; Cherini, G.

    2015-12-01

    We have monitored the 2014 superoutburst of the WZ Sge-type transient PNV J03093063+2638031 for more than four months, from V = 11.0 maximum brightness down to V = 18.4 mag, close to quiescence value, by obtaining BVRCIC photometry and low resolution fluxed spectroscopy. The evolution was normal and no late-time "echo" outbursts were observed. The absolute integrated flux of emission lines kept declining along the superoutburst, and their increasing contrast with the underlying continuum was simply the result of the faster decline of the continuum compared to the emission lines. Inspection of historical Harvard plates covering the 1899-1981 period did not reveal previous outbursts, neither "normal" nor "super". We discovered an extended emission nebula (radius ~1 arcmin) around PNV J03093063+2638031, that became visible for a few months as the result of photo-ionization from the superoutburst of the central star. The nebula is not present on Palomar I and II sky survey images and it quickly disappeared when the outburst was over. From the rate at wich the ionization front swept through the nebula, we derive a distance of ~120 pc to the system. The nebula is density bounded with an outer radius of 0.03 pc, and the absolute magnitude of the central star in quiescence is MV ~ 14.2 mag. The electron density in the nebula is estimated to be 105 cm-3 from the observed recombination time scale. Given the considerable substructures seen across the nebula, a low filling factor is inferred. Similar nebulae have not been reported for other WZ Sge objects and the challenges posed to models are considered. Spectra of Fig. 2 and full Table 4 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/584/A12

  19. HST Imaging of the Local Volume Dwarf Galaxies Pisces A and B: Prototypes for Local Group Dwarfs

    NASA Astrophysics Data System (ADS)

    Tollerud, Erik J.; Geha, Marla C.; Grcevich, Jana; Putman, Mary E.; Weisz, Daniel R.; Dolphin, Andrew E.

    2016-08-01

    We present observations of the Pisces A and B galaxies with the Advanced Camera for Surveys on the Hubble Space Telescope. Photometry from these images clearly resolves a red giant branch (RGB) for both objects, demonstrating that they are nearby dwarf galaxies. We describe a Bayesian inferential approach to determining the distance to these galaxies using the magnitude of the tip of the RGB, and then apply this approach to these galaxies. This reveals the distance to these galaxies as {5.64}-0.15+0.13 {{Mpc}} and {8.89}-0.85+0.75 {{Mpc}} for Pisces A and B, respectively, placing both within the Local Volume but not the Local Group (LG). We estimate the star formation histories of these galaxies, which suggests that they have recently undergone an increase in their star formation rates. Together these yield luminosities for Pisces A and B of {M}V=-{11.57}-0.05+0.06 and ‑12.9 ± 0.2, respectively, and estimated stellar masses of {log}({M}* /{M}ȯ )={7.0}-1.7+0.4 and {7.5}-1.8+0.3. We further show that these galaxies are likely at the boundary between nearby voids and higher-density filamentary structure. This suggests that they are entering a higher-density region from voids, where they would have experienced delayed evolution, consistent with their recent increased star formation rates. If this is indeed the case, they are useful for study as proxies of the galaxies that later evolved into typical LG satellite galaxies.

  20. Chromospheric Activity in Red Giants of M67

    NASA Astrophysics Data System (ADS)

    Dupree, A. K.; Whitney, B. A.; Pasquini, L.

    1994-12-01

    Red giants in the old open cluster M67 present a well-studied, homogeneous group of 1.27Msun stars with which to determine the evolution of chromospheric activity and mass loss. Echelle spectra of the Ca II H and K line region (lambda 3950) have been obtained with the 4-m telescope at KPNO, the MMT of the F. L. Whipple Observatory (K only), and the 3.6-m ESO telescope at La Silla, Chile. Spectra of 16 red giant stars down to V ~ 11 were obtained; five of the sample are identified as clump giants. The flux of the emission reversal in the Ca II K core has been calibrated using normalization based on the narrow-band absolute spectrophotometry of Gunn &\\ Stryker (1983, ApJS, 52, 121). A new spectral synthesis of the Calcium line region for radiative models of the M67 giants based on Kurucz atmospheres provides the correction necessary to extract the chromospheric component of the flux. The Ca K emission reversals display asymmetries indicative of outward motions for giants more luminous than M_V ~ +0.5. The chromospheric emission flux in Ca II K decreases with increasing stellar luminosity. Clump giants, which are thought to be in a core-helium burning stage, show Ca II emission comparable to the stars on the red giant branch. Evidence for chromospheric variability is found from multiple observations of several objects. Implications of these results upon the evolution of chromospheres and presence of mass loss in giants will be discussed.

  1. Natural cocoa consumption: Potential to reduce atherogenic factors?

    PubMed

    McFarlin, Brian K; Venable, Adam S; Henning, Andrea L; Prado, Eric A; Best Sampson, Jill N; Vingren, Jakob L; Hill, David W

    2015-06-01

    Short-term consumption of flavanol-rich cocoa has been demonstrated to improve various facets of vascular health. The purpose of the present study was to determine the effect of 4 weeks of natural cocoa consumption on selected cardiovascular disease (CVD) biomarkers in young (19-35 years) women of differing body mass indices (BMI; normal, overweight or obese). Subjects (n = 24) consumed a natural cocoa-containing product (12.7 g natural cocoa, 148 kcal/serving) or an isocaloric cocoa-free placebo daily for 4 weeks in a random, double-blind manner with a 2-week washout period between treatment arms. Fasted (>8-h) blood samples were collected before and after each 4-week period. Serum was analyzed to determine lipid profile (chemistry analyzer) and CVD biomarkers (26 biomarkers). EDTA-treated blood was used to assess monocytes (CD14, CD16, v11b and CD62L), while citrate-treated blood was used to measure changes in endothelial microparticles (EMPs; CD42a-/45-/144+) by flow cytometry. Natural cocoa consumption resulted in a significant decrease in haptoglobin (P = .034), EMP concentration (P = .017) and monocyte CD62L (P = .047) in obese compared to overweight and normal-weight subjects. Natural cocoa consumption regardless of BMI group was associated with an 18% increase in high-density lipoprotein (P = .020) and a 60% decrease in EMPs (P = .047). Also, obese subjects experienced a 21% decrease in haptoglobin (P = .034) and a 24% decrease in monocyte CD62L expression in (P = .047) following 4 weeks of natural cocoa consumption. Collectively, these findings indicate that acute natural cocoa consumption was associated with decreased obesity-related disease risk. More research is needed to assess the stability of the observed short-term changes. PMID:25769436

  2. Characterization of the KOI-273 Planetary System with HARPS-N

    NASA Astrophysics Data System (ADS)

    Gettel, Sara; Charbonneau, David; Harps-N Collaboration

    2015-01-01

    The NASA Kepler mission detected thousands of planets with radii between 1 and 3 Earth radii, a population with no analog in our own solar system. The composition of these objects is not yet well understood; some of these may be planets that are predominantly rocky and others may be planets with a large fractional composition of volatiles or a substantial hydrogen envelope. There are only seven planets smaller than 2.5 Re with published mass estimates with a precision better than 20%, the minimum required to distinguish between different compositional models.HARPS-N is an ultra-stable, fiber-fed, high-resolution spectrograph optimized for the measurement of very precise radial velocities. A primary goal of the HARPS-N collaboration is to measure precisely the masses of small transiting planets and so constrain their individual compositions.KOI-273 is a solar-like star (Teff = 5783, log(g) = 4.43, V = 11.68) with a 1.8 Earth-radius planet candidate in a 10.5-d orbit. During the 2014 Kepler observing season, we obtained 50 observations of this star, with a median photon-limited radial velocity precision of 1.9 m/s. Our data indicated the presence of an outer, massive companion. We present the orbital solution of this system and measure the bulk density and inferred composition of the inner planet.HARPS-N was funded by the Swiss Space Office, the Harvard Origin of Life Initiative, the Scottish Universities Physics Alliance, the University of Geneva, the Smithsonian Astrophysical Observatory, and the Italian National Astrophysical Institute, University of St. Andrews, Queens University Belfast, and University of Edinburgh. This work was made possible through a grant from the John Templeton Foundation.

  3. Acute consumption of a caffeinated energy drink enhances aspects of performance in sprint swimmers.

    PubMed

    Lara, Beatriz; Ruiz-Vicente, Diana; Areces, Francisco; Abián-Vicén, Javier; Salinero, Juan José; Gonzalez-Millán, Cristina; Gallo-Salazar, César; Del Coso, Juan

    2015-09-28

    This study investigated the effect of a caffeinated energy drink on various aspects of performance in sprint swimmers. In a randomised and counterbalanced order, fourteen male sprint swimmers performed two acute experimental trials after the ingestion of a caffeinated energy drink (3 mg/kg) or after the ingestion of the same energy drink without caffeine (0 mg/kg; placebo). After 60 min of ingestion of the beverages, the swimmers performed a countermovement jump, a maximal handgrip test, a 50 m simulated competition and a 45 s swim at maximal intensity in a swim ergometer. A blood sample was withdrawn 1 min after the completion of the ergometer test. In comparison with the placebo drink, the intake of the caffeinated energy drink increased the height in the countermovement jump (49.4 (SD 5.3) v. 50.9 (SD 5.2) cm, respectively; P<0.05) and maximal force during the handgrip test with the right hand (481 (SD 49) v. 498 (SD 43) N; P<0.05). Furthermore, the caffeinated energy drink reduced the time needed to complete the 50 m simulated swimming competition (27.8 (SD 3.4) v. 27.5 (SD 3.2) s; P<0.05), and it increased peak power (273 (SD 55) v. 303 (SD 49) W; P <0.05) and blood lactate concentration (11.0 (SD 2.0) v. 11.7 (SD 2.1) mM; P<0.05) during the ergometer test. The caffeinated energy drink did not modify the prevalence of insomnia (7 v. 7%), muscle pain (36 v. 36%) or headache (0 v. 7%) during the hours following its ingestion (P>0.05). A caffeinated energy drink increased some aspects of swimming performance in competitive sprinters, whereas the side effects derived from the intake of this beverage were marginal at this dosage. PMID:26279580

  4. Biaxial flexural strength of Turkom-Cera core compared to two other all-ceramic systems

    PubMed Central

    AL-MAKRAMANI, Bandar Mohammed Abdullah; RAZAK, Abdul Aziz Abdul; ABU-HASSAN, Mohamed Ibrahim

    2010-01-01

    Advances in all-ceramic systems have established predictable means of providing metal-free aesthetic and biocompatible materials. These materials must have sufficient strength to be a practical treatment alternative for the fabrication of crowns and fixed partial dentures. Objectives The aim of this study was to compare the biaxial flexural strength of three core ceramic materials. Material and methods Three groups of 10 disc-shaped specimens (16 mm diameter x 1.2 mm thickness - in accordance with ISO-6872, 1995) were made from the following ceramic materials: Turkom-Cera Fused Alumina [(Turkom-Ceramic (M) Sdn Bhd, Puchong, Selangor, Malaysia)], In-Ceram (Vita Zahnfabrik, Bad Säckingen, Baden-Württemberg, Germany) and Vitadur-N (Vita Zahnfabrik, Bad Säckingen, Baden-Württemberg, Germany), which were sintered according to the manufacturer's recommendations. The specimens were subjected to biaxial flexural strength test in a universal testing machine at a crosshead speed of 0.5 mm/min. The definitive fracture load was recorded for each specimen and the biaxial flexural strength was calculated from an equation in accordance with ISO-6872. Results The mean biaxial flexural strength values were: Turkom-Cera: 506.8±87.01 MPa, In-Ceram: 347.4±28.83 MPa and Vitadur-N: 128.7±12.72 MPa. The results were analyzed by the Levene's test and Dunnett's T3 post-hoc test (SPSS software V11.5.0 for Windows, SPSS, Chicago, IL, USA ) at a preset significance level of 5% because of unequal group variances (P<0.001). There was statistically significant difference between the three core ceramics (P<0.05). Turkom-Cera showed the highest biaxial flexural strength, followed by In-Ceram and Vitadur-N. Conclusions Turkom-Cera core had significantly higher flexural strength than In-Ceram and Vitadur-N ceramic core materials. PMID:21308292

  5. Anthropometric, metabolic, psychosocial and dietary factors associated with dropout in overweight and obese postmenopausal women engaged in a 6-month weight loss programme: a MONET study.

    PubMed

    Messier, Virginie; Hayek, Jessy; Karelis, Antony D; Messier, Lyne; Doucet, Eric; Prud'homme, Denis; Rabasa-Lhoret, Rémi; Strychar, Irene

    2010-04-01

    The objective of the present study was to examine anthropometric, metabolic, psychosocial and dietary factors associated with dropout in a 6-month weight loss intervention aimed at reducing body weight by 10 %. The study sample included 137 sedentary, overweight and obese postmenopausal women, participating in a weight loss intervention that consisted of either energy restriction (ER) or ER with resistance training (ER+RT). Anthropometric (BMI, percent lean body mass, percent fat mass, visceral adipose tissue and waist circumference), metabolic (total energy expenditure, RMR, insulin sensitivity and fasting plasma levels of leptin and ghrelin), psychosocial (body esteem, self-esteem, stress, dietary restraint, disinhibition, hunger, quality of life, self-efficacy, perceived benefits for controlling weight and perceived risk) and dietary (3-d food record) variables were measured. Thirty subjects out of 137 dropped out of the weight loss programme (22 %), with no significant differences in dropout rates between those in the ER and the ER+RT groups. Overall, amount of weight loss was significantly lower in dropouts than in completers ( - 1.7 (sd 3.5) v. - 5.6 (sd 4.3) kg, P < 0.05); weekly weight loss during the first 4 weeks was also significantly lower. Dropouts consumed fewer fruit servings than completers (1.7 (sd 1.1) v. 2.7 (sd 1.53), P < 0.05) and had higher insulin sensitivity levels (12.6 (sd 3.8) v. 11.1 (sd 2.8) mg glucose/min per kg fat-free mass, P < 0.05). The present results suggest that the rate of weight loss during the first weeks of an intervention plays an important role in the completion of the programme. Thus, participants with low rates of initial weight loss should be monitored intensely to undertake corrective measures to increase the likelihood of completion. PMID:19930768

  6. Two Transiting Low Density Sub-Saturns from K2

    NASA Astrophysics Data System (ADS)

    Petigura, Erik A.; Howard, Andrew W.; Lopez, Eric D.; Deck, Katherine M.; Fulton, Benjamin J.; Crossfield, Ian J. M.; Ciardi, David R.; Chiang, Eugene; Lee, Eve J.; Isaacson, Howard; Beichman, Charles A.; Hansen, Brad M. S.; Schlieder, Joshua E.; Sinukoff, Evan

    2016-02-01

    We report the discovery and confirmation of K2-24 b and c, two sub-Saturn planets orbiting a bright (V = 11.3), metal-rich ([Fe/H] = 0.42 ± 0.04 dex) G3 dwarf in the K2 Campaign 2 field. The planets are 5.68 ± 0.56 {R}\\oplus and 7.82 ± 0.72 {R}\\oplus and have orbital periods of 20.8851 ± 0.0003 days and 42.3633 ± 0.0006 days, near the 2:1 mean-motion resonance. We obtained 32 radial velocities with Keck/HIRES and detected the reflex motion due to K2-24 b and c. These planets have masses of 21.0 ± 5.4 {M}\\oplus and 27.0 ± 6.9 {M}\\oplus , respectively. With low densities of 0.63 ± 0.25 g cm-3 and 0.31 ± 0.12 g cm-3, respectively, the planets require thick envelopes of H/He to explain their large sizes and low masses. Interior structure models predict that the planets have fairly massive cores of 17.6+/- 4.3 {M}\\oplus and 16.1+/- 4.2 {M}\\oplus , respectively. They may have formed exterior to their present locations, accreted their H/He envelopes at large orbital distances, and migrated in as a resonant pair. The proximity to resonance, large transit depths, and host star brightness offers rich opportunities for TTV follow-up. Finally, the low surface gravities of the K2-24 planets make them favorable targets for transmission spectroscopy by Hubble Space Telescope, Spitzer, and James Webb Space Telescope.

  7. Threecornered alfalfa hopper (Hemiptera: Membracidae): seasonal occurrence, girdle distribution, and response to insecticide treatment on peanut in South Carolina.

    PubMed

    Rahman, Khalidur; Bridges, William C; Chapin, Jay W; Thomas, James S

    2007-08-01

    A survey of threecornered alfalfa hopper, Spissistilus festinus (Say) (Hemiptera: Membracidae), damage in 60 South Carolina peanut, Arachis hypogaea L., fields showed that 89 and 58% of plants had feeding girdles during 2003 and 2004, respectively. Use of a foliar insecticide for other target pests reduced hopper damage. Hopper damage was not affected by sampling distance from the field edge; therefore, injury was adequately assessed at 10 m from field borders. In-furrow insecticide choice, planting date, soil texture, previous crop, or tillage did not measurably affect girdling. Subsequent field experiments demonstrated a cultivar effect on threecornered alfalfa hopper injury, with the standard runner-type cultivar ('Georgia Green') more susceptible than the standard Virginia-type ('NC-V11'). More than 50% of stem girdling occurred on the basal quarter (first five internodes) of the plant. Most feeding occurred on secondary branches of main and lateral stems. Weekly sampling of seven grower fields showed that adult hoppers colonize peanut during June and produce two generations on peanut. Only low levels of plant girding were observed in June, but plant girdling increased gradually through late July, when girdling markedly increased contemporary with peak populations of first generation nymphs and adults. A second increase in plant girdling, observed in early September, coincided with the second generation of nymphs on peanut. Foliar treatments at 45- 60 d after planting (DAP) were most effective in suppressing injury. Granular chlorpyrifos treatment also suppressed hopper injury. There was no yield response to insecticide treatments at the hopper injury levels in these tests (up to six girdles per plant). Although the economic injury level (EIL) for this pest has not been defined, our data indicate that a critical interval for monitoring hopper activity is the first 3 wk of July, before the occurrence of significant injury. Where growers have a consistent risk of

  8. Molecular Characterization of Streptococcus agalactiae Isolates From Pregnant and Non-Pregnant Women at Yazd University Hospital, Iran

    PubMed Central

    Sadeh, Maryam; Firouzi, Roya; Derakhshandeh, Abdollah; Bagher Khalili, Mohammad; Kong, Fanrong; Kudinha, Timothy

    2016-01-01

    Background: Streptococcus agalactiae (Group B streptococcus, GBS) that colonize the vaginas of pregnant women may occasionally cause neonatal infections. It is one of the most common causes of sepsis and meningitis in neonates and of invasive diseases in pregnant women. It can also cause infectious disease among immunocompromised individuals. The distribution of capsular serotypes and genotypes varies over time and by geographic era. The serotyping and genotyping data of GBS in Iranian pregnant and non-pregnant women seems very limited. Objectives: The aim of this study was to investigate the GBS ‎molecular capsular serotype ‎and genotype distribution of pregnant and non-pregnant carrier ‎women at Yazd university hospital, in Iran.‎ Patients and Methods: In this cross-sectional study, a total of 100 GBS strains isolated from 237 pregnant and 413 non-pregnant women were investigated for molecular capsular serotypes and surface protein genes using the multiplex PCR assay. The Chi-square method was used for statistical analysis. Results: Out of 650 samples, 100 (15.4%) were identified as GBS, with a predominance of capsular serotypes III (50%) [III-1 (49), III-3 (1)], followed by II (25%), Ia (12%), V (11%), and Ib (2%), which was similar with another study conducted in Tehran, Iran, but they had no serotype Ia in their report. The surface protein antigen genes distribution was rib (53%), epsilon (38%), alp2/3 (6%), and alpha-c (3%). Conclusions: The determination of serotype and surface proteins of GBS strains distribution would ‎be ‎relevant ‎for the future possible formulation of a GBS vaccine. PMID:27127592

  9. Computationally efficient real-time interpolation algorithm for non-uniform sampled biosignals

    PubMed Central

    Eftekhar, Amir; Kindt, Wilko; Constandinou, Timothy G.

    2016-01-01

    This Letter presents a novel, computationally efficient interpolation method that has been optimised for use in electrocardiogram baseline drift removal. In the authors’ previous Letter three isoelectric baseline points per heartbeat are detected, and here utilised as interpolation points. As an extension from linear interpolation, their algorithm segments the interpolation interval and utilises different piecewise linear equations. Thus, the algorithm produces a linear curvature that is computationally efficient while interpolating non-uniform samples. The proposed algorithm is tested using sinusoids with different fundamental frequencies from 0.05 to 0.7 Hz and also validated with real baseline wander data acquired from the Massachusetts Institute of Technology University and Boston's Beth Israel Hospital (MIT-BIH) Noise Stress Database. The synthetic data results show an root mean square (RMS) error of 0.9 μV (mean), 0.63 μV (median) and 0.6 μV (standard deviation) per heartbeat on a 1 mVp–p 0.1 Hz sinusoid. On real data, they obtain an RMS error of 10.9 μV (mean), 8.5 μV (median) and 9.0 μV (standard deviation) per heartbeat. Cubic spline interpolation and linear interpolation on the other hand shows 10.7 μV, 11.6 μV (mean), 7.8 μV, 8.9 μV (median) and 9.8 μV, 9.3 μV (standard deviation) per heartbeat. PMID:27382478

  10. The Use of Guidelines for Lower Respiratory Tract Infections in Tanzania: A Lesson from Kilimanjaro Clinicians

    PubMed Central

    Mbwele, B; Slot, A; De Mast, Q; Kweka, P; Msuya, M; Hulscher, M

    2016-01-01

    Background: Evaluations of the guidelines for the management of Lower Respiratory Tract Infections (LRTI) Sub-Saharan Africa, particularly in Tanzania is scant. Aim: The aim of the study was to assess the usefulness of the current Tanzanian treatment guideline for the management lower respiratory tract infection. Subjects and Methods: A descriptive cross sectional study in 11 hospitals of different levels in the Kilimanjaro region Data were collected from May 2012 to July 2012 by semi-structured interview for clinicians using 2 dummy cases for practical assessment. Data were analyzed by STATA v11 (StataCorp, TX, USA). Qualitative narratives from the interviews were translated, transcribed then coded by colors into meaningful themes. Results: A variety of principles for diagnosing and managing LRTI were demonstrated by 53 clinicians of Kilimanjaro. For the awareness, 67.9% (36/53) clinicians knew their responsibility to use Standard Treatment Guideline for managing LRTI. The content derived from Standard Treatment Guideline could be cited by 11.3% of clinicians (6/53) however they all showed concern of gaps in the guideline. Previous training in the management of patients with LRTI was reported by 25.9% (14/53), majority were pulmonary TB related. Correct microorganisms causing different forms of LRTI were mentioned by 11.3% (6/53). Exact cause of Atypical pneumonia and Q fever as an example was stated by 13.0% (7/53) from whom the need of developing the guideline for LRTI was explicitly elaborated. Conclusion: The current guidelines have not been used effectively for the management of LRTI in Tanzania. There is a need to review its content for the current practical use. PMID:27213093

  11. Vorticity and upscaled dispersion in 3D heterogeneous porous media

    NASA Astrophysics Data System (ADS)

    Di Dato, Mariaines; Chiogna, Gabriele; de Barros, Felipe; Bellin, Alberto; Fiori, Aldo

    2015-04-01

    Modeling flow in porous media is relevant for many environmental, energy and industrial applications. From an environmental perspective, the relevance of porous media flow becomes evident in subsurface hydrology. In general, flow in natural porous media is creeping, yet the large variability in the hydraulic conductivity values encountered in natural aquifers leads to highly heterogeneous flow fields. This natural variability in the conductivity field will affect both dilution rates of chemical species and reactive mixing. A physical consequence of this heterogeneity is also the presence of a various localized kinematical features such as straining, shearing and vorticity in aquifers, which will influence the shape of solute clouds and its fate and transport. This work aims in fundamentally characterizing the vorticity field in spatially heterogeneous flow fields as a function of their statistical properties in order to analyze the impact on transport processes. In our study, three-dimensional porous formations are constructed with an ensemble of N independent, non-overlapping spheroidal inclusions submerged into an homogeneous matrix, of conductivity K0. The inclusions are randomly located in a domain of volume W and are fully characterized by the geometry of spheroid (oblate or prolate), their conductivity K (random and drawn from a given probability density function fκ), the centroid location ¯x, the axes ratio e, the orientation of the rotational axis (α1,α2) and the volume w. Under the assumption of diluted medium, the flow problem is solved analitically by means of only two parameters: the conductivity contrast κ = K/K0 and the volume fraction n = Nw/W . Through the variation of these parameters of the problem, it is possible to approximate the structure of natural heterogeneous porous media. Using a random distribution of the orientation of the inclusions, we create media defined by the same global anisotropy f = Iz/Ix but different micro

  12. The massive galaxy cluster XMMU J1230.3+1339 at z ˜ 1: colour-magnitude relation, Butcher-Oemler effect, X-ray and weak lensing mass estimates

    NASA Astrophysics Data System (ADS)

    Lerchster, M.; Seitz, S.; Brimioulle, F.; Fassbender, R.; Rovilos, M.; Böhringer, H.; Pierini, D.; Kilbinger, M.; Finoguenov, A.; Quintana, H.; Bender, R.

    2011-03-01

    We present results from the multiwavelength study of XMMU J1230.3+1339 at z˜ 1. We analyse deep multiband wide-field images from the Large Binocular Telescope (LBT), multi-object spectroscopy observations from VLT, as well as space-based serendipitous observations, from the GALEX and Chandra X-ray observatories. We apply a Bayesian photometric redshift code to derive the redshifts using the far-UV (FUV), near-UV (NUV) and the deep U, B, V, r, i, z data. We make further use of spectroscopic data from FORS2 to calibrate our photometric redshifts, and investigate the photometric and spectral properties of the early-type galaxies. We achieve an accuracy of ▵z/(1 +z)= 0.07 (0.04) and the fraction of catastrophic outliers is η= 13 (0) per cent, when using all (secure) spectroscopic data, respectively. The i-z against z colour-magnitude relation of the photo-z members shows a tight red sequence with a zero-point of 0.935 mag, and slope equal to -0.027. We observe evidence for a truncation at the faint end of the red-cluster-sequence and the Butcher-Oemler effect, finding a fraction of blue galaxies fb≈ 0.5. Further, we conduct a weak lensing analysis of the deep 26 × 26 arcmin r-band LBC image. The observed shear is fitted with a Single-Isothermal-Sphere and a Navarro-Frenk-White model to obtain the velocity dispersion and the model parameters, respectively. Our best-fitting values are, for the velocity dispersion σSIS= 1308 ± 284 km s-1, concentration parameter c= 4.0+14-2 and scale radius rs= 345+50-57 kpc. From a 38 ks Chandra X-ray observation we obtain an independent estimate of the cluster mass. In addition, we create a signal-to-noise ratio (S/N) map for the detection of the matter mass distribution of the cluster using the mass-aperture technique. We find excellent agreement of the mass concentration identified with weak lensing and the X-ray surface brightness. Combining our mass estimates from the kinematic, X-ray and weak lensing analyses we obtain a

  13. Operative and technological management of super-large united power grids: lessons of major world's blackouts

    NASA Astrophysics Data System (ADS)

    Brinkis, K.; Kreslins, V.; Mutule, A.

    2014-02-01

    Power system (PS) blackouts still persist worldwide, evidencing that the existing protective structures need to be improved. The discussed requirements and criteria to be met for joint synchronous operation of large and super-large united PSs should be based on close co-ordination of operative and technological management of all PSs involved in order to ensure secure and stable electricity supply and minimise or avoid the threat of a total PS blackout. The authors analyse the July 2012 India blackout - the largest power outage in history, which affected over 620 million people, i.e. half of India's population and spread across its 22 states. The analysis is of a general character, being applicable also to similar blackouts that have occurred in Europe and worldwide since 2003. The authors summarise and develop the main principles and methods of operative and technological management aimed at preventing total blackouts in large and super-large PSs. Neskatoties uz sasniegumiem elektroenerģētikas jomā un energosistēmu nepārtrauktu modernizāciju, pasaulē regulāri notiek sabrukumu avārijas. Rakstā apskatīti lielu un superlielu energosistēmu apvienību savstarpējas sinhronas darbības nodrošinājuma prasības un kritēriji, kas pamatojas uz operatīvās un tehnoloģiskās vadības ciešu koordināciju starp energosistēmām. Savstarpējas sinhronas darbības nodrošinājuma prasībām un kritērijiem ir izšķiroša nozīme, lai panāktu elektroapgādes drošumu un stabilitāti katrā energosistēmā, kas darbojas apvienotas energosistēmas sastāvā. Šo prasību un kritēriju ievērošana sekmē totālo avāriju izcelšanās iespēju samazināšanu un to novēršanu. Indijas 2012.gada totālo avāriju un citu analogo avāriju Eiropā un Amerikā analīze un izvērtējums laika posmā no 2003.gada, deva iespēju apkopot un izstrādāt lielu un superlielu energosistēmu operatīvās un tehnoloģiskās vadības principus un metodoloģiju, lai novērstu vai

  14. Geological and geophysical activities at Spallanzani Science Department (Liceo Scientifico Statale "Lazzaro Spallanzani" - Tivoli, Italy)

    NASA Astrophysics Data System (ADS)

    Favale, T.; De Angelis, F.; De Filippis, L.

    2012-04-01

    The high school Liceo Scientifico "Lazzaro Spallanzani" at Tivoli (Rome) has been fully involved in the study of geological and geophysical features of the town of Tivoli and the surrounding area in the last twelve years. Objective of this activity is to promote the knowledge of the local territory from the geological point of view. Main activities: • School year 2001-2002: Setting up inside the school building of a Geological Museum focusing on "Geological Evolution of Latium, Central Italy" (in collaboration with colleagues M. Mancini, and A. Pierangeli). • March, 15, 2001: Conference of Environmental Geology. Lecturer: Prof. Raniero Massoli Novelli, L'Aquila University and Società Italiana di Geologia Ambientale. • School years 2001-2002 and 2002-2003: Earth Sciences course for students "Brittle deformation and tectonic stress in Tivoli area". • November, 2003: Conference of Geology, GIS and Remote Sensing. Lecturers: Prof. Maurizio Parotto and Dr Alessandro Cecili (Roma Tre University, Rome), and Dr Stefano Pignotti (Istituto Nazionale per la Ricerca sulla Montagna, Rome). • November, 2003, 2004 and 2005: GIS DAY, organized in collaboration with ESRI Italia. • School year 2006-2007: Earth Sciences course for students "Acque Albule basin and the Travertine of Tivoli, Latium, Central Italy" (focus on travertine formation). • School year 2010-2011: Earth Sciences course for students "Acque Albule basin and the Travertine of Tivoli. Geology, Hydrogeology and Microbiology of the basin, Latium, Central Italy" (focus on thermal springs and spa). In the period 2009-2010 a seismic station with three channels, currently working, was designed and built in our school by the science teachers Felice De Angelis and Tomaso Favale. Our seismic station (code name LTTV) is part of Italian Experimental Seismic Network (IESN) with identification code IZ (international database IRIS-ISC). The three drums are online in real time on websites http

  15. Textural and petrological characteristics of ultrahigh-pressure chromitites, indicating a mantle recycling origin?

    NASA Astrophysics Data System (ADS)

    Arai, Shoji; Miura, Makoto; Yamamoto, Shinji; Shmelev, Vladimir

    2013-04-01

    examine the nodular-textured UHP chromitites from Luobusa (Yamamoto et al., 2009) to compare with nodular-textured chromities from the Oman ophiolite, which we consider as of typical low-P origin. They are completely different. The chromite nodule is an aggregate of subhedral to euhedral chromian spinel grains with interstitial olivine from the Oman chromitite, but is apparently an oval-shaped spinel grain cut by fractures filled with olivine (= COF (chromite cut by olivine-filled fractures) texture). Similar COF texture was confirmed from possible UHP chromitites from Ray-Iz ophiolite, the Polar Urals (Trumbull et al., 2009; Shmelev, 2011). Chromian spinel is totally free from pargasite and other inclusions in UHP chromitites (Miura et al., 2012). Olivine in chromitites with the COF texture is characterized by exceptionally high NiO contents (up to more than 1 wt%). These characteristics are apparently consistent with the deep recycling origin for the UHP chromitites. The COF texture is a result of a rheological contrast between olivine and chromian spinel during the travel of the chromitite in the mantle. The high Ni character of olivine is due to diffusion of Ni from chromian spinel during the recycling. The primary nodular-textured chromitite of low-P igneous origin can be basically preserved even after deep recycling, although compaction and possible phase transformation had occurred.

  16. Análisis de la formación de galaxias en grupos

    NASA Astrophysics Data System (ADS)

    Pérez, M. J.; Tissera, P.; García Lambas, D.

    The actual cosmological paradigm postulates that structure formation occurs in a hierarchical way. In such scenarios, interactions among galaxies are frequent and play an important role in determining their properties, and particularly, in the regulation of star formation. Observations show that interactions and collisions can increase the star formation rate (Larson & Tinsley 1978; Donzelli & Pastoriza 1997; Barton et al 1998). In particular, recent observational results (García Lambas, Tissera, Alonso & Coldwell, 2003) show that star formation in galaxy pairs is significantly enhanced over that of isolated galaxies with the same redshift distribution. Theoretical interpretation of these observational results could be associated to the dynamical stability of galactic systems. Numerical simulations show that disc galaxies without bulges or with small ones, tend to develop instabilities induced by tidal interactions which produce gas inflows and trigger star formation (Mihos & Hernquist 1996; Domínguez-Tenreiro, Tissera & Sáiz 1998). Although simulations and observations show the effects of galaxy interactions on the star formation, intrinsic properties of galaxies in pairs must play a crucial role due to high observed fraction of galaxies pairs with low star formation rate (García Lambas et al 2003). In order to see if these observational results are reproduced in hierarhical clustering scenarios, we study the star formation of galaxy pairs, as well as any possible effects provoked by interactions on other astrophysical properties, such the chemical ones. For this purpose, we use hydrodynamical simulations consistent with a CDM model: Ω=1, Λ=0 and H0=50 km s-1 Mpc-1, which include star formation and chemical evolution (Mosconi et al 2001). We analyzed three different realizations of the power spectrum in the redshift range of the 2dFGRS catalog (García Lambas et al. 2003). Identified structures were classified as isolated galaxies and galaxies in closed

  17. Ni-Al Protective Coating of Steel Electrodes in Dc Electrolysis for Hydrogen Production / Ni-Al Pārklājuma Ietekme Uz Tērauda Elektrodiem Līdzstrāvas Elektrolīzē Ūdeņraža Ražošanai

    NASA Astrophysics Data System (ADS)

    Aizpurietis, P.; Vanags, M.; Kleperis, J.; Bajars, G.

    2013-04-01

    Hydrogen can be a good alternative to fossil fuels under the conditions of world's crisis as an effective energy carrier derived from renewable resources. Among all the known methods of hydrogen production, water electrolysis gives the ecologically purest hydrogen, so it is of importance to maximize the efficiency of this process. The authors consider the influence of plasma sprayed Ni-Al protective coating of 316L steel anode-cathode electrodes in DC electrolysis. In a long-term (24 h) process the anode corrodes strongly, losing Cr and Ni ions which are transferred to the electrolyte, while only minor corrosion of the cathode occurs. At the same time, the composition of anode and cathode electrodes protected by Ni-Al coating changes only slightly during a prolonged electrolysis. As the voltammetry and Tafel plots evidence, the Ni-Al coating protects both the anode and cathode from the corrosion and reduces the potential of hydrogen evolution. The results obtained show that such a coating works best in the case of steel electrodes. Darbā pētīts, kā līdzstrāvas elektrolīzē tērauda 316L elektrodus (anods un katods) ietekmē ar plazmas izputināšanas metodi iegūts Ni-Al pārklājums. Tikko uznestam pārklājumam ir mikrostrukturēta virsma, kas kodināšanas laikā mainās, gan pēc reljefa, gan elementu sastāva. Veicot ilgstošu (24 stundas elektrolīzi), atrasts, ka tikai tērauda elektrods anoda lomā intensīvi korodē un zaudē hroma un niķeļa jonus, kas pāriet elektrolītā, turpretī katods mainās relatīvi maz. Pārklājums Ni-Al pēc uznešanas tiek kodināts karstā sārmā, kad tiek izšķīdināta daļa sastāvā esošo elementu (Al, Si, Cd), bet ilgstošas elektrolīzes laikā pārklājuma sastāvs mainās maz gan anodam, gan katodam. Elektrodu elektroķīmiskie raksturlielumi noteikti ar voltamperometrijas un Tāfeļa līkņu analīzes metodēm. Atrasts, ka Ni-Al pārklājums aizsargā gan anodu, gan katodu no korozijas un samazina

  18. Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics

    PubMed Central

    2012-01-01

    predicts the presence of novel trafficking-related components, and also the organizational logic that allows toxin diversification through recombination. Domain architecture and protein-length analysis revealed that these toxins might be deployed as secreted factors, through directed injection, or via inter-cellular contact facilitated by filamentous structures formed by RHS/YD, filamentous hemagglutinin and other repeats. Phyletic pattern and life-style analysis indicate that polymorphic toxins and polyimmunity loci participate in cooperative behavior and facultative ‘cheating’ in several ecosystems such as the human oral cavity and soil. Multiple domains from these systems have also been repeatedly transferred to eukaryotes and their viruses, such as the nucleo-cytoplasmic large DNA viruses. Conclusions Along with a comprehensive inventory of toxins and immunity proteins, we present several testable predictions regarding active sites and catalytic mechanisms of toxins, their processing and trafficking and their role in intra-specific and inter-specific interactions between bacteria. These systems provide insights regarding the emergence of key systems at different points in eukaryotic evolution, such as ADP ribosylation, interaction of myosin VI with cargo proteins, mediation of apoptosis, hyphal heteroincompatibility, hedgehog signaling, arthropod toxins, cell-cell interaction molecules like teneurins and different signaling messengers. Reviewers This article was reviewed by AM, FE and IZ. PMID:22731697

  19. Climatic record of the Iberian peninsula from lake Moncortes' sediments

    NASA Astrophysics Data System (ADS)

    Cao, Min; Huguet, Carme; Rull, Valenti; Valero, Blas; Rosell-Mele, Antoni

    2014-05-01

    .19km2. Lake Moncortes is situated at 1065 m above sea level, has an average temperature of 10ºC (minimum 3 and maximum 16ºC) and a mean annual precipitation of 770mm. We used the MBT/CBT (Weijers et al. 2007) proxy of pH and terrestrial temperature and the TEX86 temperature proxy (Schouten et al. 2002) to estimate changes in and around the lake. Both proxies are based on the glycerol dialkyl glycerol tetraethers (GDGTs) of archaea (isoprenoid GDGTs) and bacteria (branched GDGTs) origin. We also measured soils surrounding the lake (Menges et al. 2013) in order to establish end-members for the proxies as well as organic matter transport. Data on n-alkane isotopes will help establish hydrographic regime changes. We observe changes in temperature and humidity consistent with those on teh northern hemisphere. J. Menges, C. Huguet, J.M. Alcañiz, S. Fietz, D. Sachse, A. Rosell-Melé Biogechemistry discussions (2013), BGD bg-2013-198. S. Schouten, E.C. Hopmans, E. Schefuss, J.S.S. Damste, Earth and Planetary Science Letters 204(2002) 265-274 J.W.H. Weijers, S. Schouten, J.S.S. Damste, Geochimica Et Cosmochimica Acta 71(2007) A1098-A1098.

  20. Digital Base Band Converter As Radar Vlbi Backend / Dbbc Kā Ciparošanas Sistēma Radara Vlbi Novērojumiem

    NASA Astrophysics Data System (ADS)

    Tuccari, G.; Bezrukovs, Vl.; Nechaeva, M.

    2012-12-01

    can then allow exploring easily the desired range of search for unknown or not fully determined orbit objects. These features make Radar VLBI personality most useful in the space debris measurements. DBBC sistēma izstrādāta Noto Radioastronomijas institūtā. Sistēmas galvenaisuzdevums - palielināt visa Eiropas VLBI tīkla jutību - realizēts, palielinotvisas novērojamās joslas platumu un pielietojot ciparu signālu apstrādes metodes.Izejas datu plūsma palielināta no 1 līdz 4 Gbps katram radioteleskopam un visasoperācijas, kas saistītas ar signālu apstrādi (frekvences pārveidošana, pastiprinājums,iekšējie ģeneratori, utt.), realizētas digitālā formā, kas ļauj iegūt nozīmīgusuzlabojumus atkārtojamībā, precizitātē, vienkāršībā, nemaz neminot vispārzināmāspriekšrocības, ko nodrošina digitālo tehnoloģiju izmantošana. Maksimālā ieejassignāla frekvenču josla ir 3.5 GHz, un momentānais joslas platums ir līdz 1 GHz uzkatru no astoņiem iespējamajiem RF/IF kanāliem. Šī datu reģistrācijas sistēma irļoti veiktspējīga platforma ne tikai EVN, bet arī citiem radioastronomijas pielietojumiem,un papildus tiek izstrādāta vesela virkne programmatūras pakotņu, kasvēl vairāk paplašina sistēmas funkcionalitāti. Tas ietver PFB (Polifāzes FiltruBanka) uztvērējus "Spectra”, kas piemēroti augstas izšķirtspējas spektroskopijasvajadzībām. Papildus realizēts jaunas programmatūras risinājums, ar mērķiizmantot DBBC sistēmu kā daudzfunkcionālu datu ciparošanas iekārtu, kasizmantojama bistatiskiem radara novērojumiem, tai skaitā arī radara VLBInovērojumiem. Šāda veida novērojumos tiek pētīta kosmisko atlūzu populācija,nodrošinot iespēju detektēt pat centimetra

  1. VizieR Online Data Catalog: STEREO non-magnetic chemically peculiar stars (Paunzen+, 2013)

    NASA Astrophysics Data System (ADS)

    Paunzen, E.; Wraight, K. T.; Fossati, L.; Netopil, M.; White, G. J.; Bewsher, D.

    2014-03-01

    We have analysed the photometric data obtained with the STEREO spacecraft for 558 non-magnetic chemically peculiar (CP) stars to search for rotational and pulsational variability. Applying the Lomb-Scargle and the phase dispersion minimization methods, we have detected photometric variability for 44 objects from which 35 were previously unknown. The new objects are all bright stars on the ecliptic plane (magnitude range 4.7<V<11.7) and will therefore be of great interest to studies of stellar structure and evolution. In particular, several show multiple signals consistent with hybrid δ Scuti and γ Doradus pulsation, with different periodicities allowing very different regions of the stellar interior to be studied. There are two subgroups of stars in our sample: the cool metallic line Am (CP1) and the hot HgMn (CP3) stars. These objects fall well inside the classical instability strip where δ Scuti, γ Doradus and slowly pulsating B-type stars are located. We also expect to find periods correlated to the orbital period for CP1 objects as they are mostly members of binary systems. For CP3 stars, rotationally induced variability is still a matter of debate. Although surface spots were detected, they are believed to produce only marginal photometric amplitudes. So, periods from several hours to a few days were expected for these two star groups. The STEREO/HI-1 data are well matched to studies of this frequency domain, owing to the cadence of approximately 40-min and multiple epochs over four and a half years. The remaining 514 stars are likely to be constant in the investigated range from 0.1 to 10d. In some cases, the presence of blending or systematic effects prevented us from detecting any reliable variability and in those cases we classified the star as constant. We discuss our results in comparison to already published ones and find a very good agreement. Finally, we have calibrated the variable stars in terms of the effective temperature and luminosity in

  2. Spontaneous late improvement of myocardial viability in the chronic infarct zone is possible, depending on persistent TIMI 3 flow and a low grade stenosis of the infarct artery

    PubMed Central

    Faraggi, M; Montalescot, G; Sarda, L; Heintz, J; Doumit, D; Drobinski, G; Sotirov, I; Le Guludec, D; Thomas, D

    1999-01-01

    OBJECTIVE—In the chronic phase of myocardial infarction, the relation between myocardial recovery and infarct related artery status remains unclear. The spontaneous changes in rest-redistribution thallium defect size were prospectively studied over six months in 52 patients with chronic Q wave myocardial infarction.
DESIGN—Changes in rest thallium defect size, thallium uptake in the infarct area, and radionuclide left ventricular ejection fraction were compared to the quantitative coronary angiogram data. Two groups of patients were considered: patients with a percentage of stenosis below 100% (group 1, n = 31); and patients with an occluded artery (group 2, n = 21). 
RESULTS—In the overall population, the mean (SD) defect size decreased from 28.2 (17.2)% to 24.9 (19.3)% of the whole myocardium (p = 0.01), while, in this area, the thallium uptake increased from 62.9 (13.7)% to 66.9 (15.6)% (p < 0.001). At the time of inclusion, the defect size, thallium uptake, and ejection fraction were similar in both groups. In group 1 patients only, the reduction in defect size correlated with the improvement in ejection fraction (r = 0.41, p = 0.02) and was related to the percentage of coronary artery stenosis. TIMI 3 patients reduced the defect size while other patients increased this defect (−5.1 (7.0)% v +11.0 (14.4)%, p < 0.001). In contrast, no significant relations were found in group 2 patients.
CONCLUSION—Late spontaneous recovery in thallium defect can occur in patients with a patent infarct related artery, depending on the TIMI flow grade and a low grade stenosis of the infarct related artery, and is associated with functional improvement.

 Keywords: myocardial infarction; thallium; infarct related artery; TIMI 3 flow grade PMID:10092571

  3. Volcanic Ash Image Products from MODIS for Aviation Safety and Natural Hazard Mitigation

    NASA Astrophysics Data System (ADS)

    Stephens, G.; Ellrod, G. P.; Im, J.

    2003-12-01

    Multi-spectral volcanic ash image products have been developed using Moderate Resolution Imaging Spectroradiometer (MODIS) data from the NASA Terra spacecraft (Ellrod and Im 2003). Efforts are now underway to integrate these new products into the MODIS Data Retrieval System at NESDIS, for use in the operational Hazard Mapping System (HMS). The images will be used at the Washington Volcanic Ash Advisory Center (W-VAAC) in the issuance of volcanic ash advisory statements to aircraft. In addition, the images will be made available to users in the global volcano and emergency management community via the World Wide Web. During the development process, good results (high detection rate with low ­false alarms­") were obtained from a tri-spectral combination of MODIS Infrared (IR) bands centered near 8.6, 11.0 and 12.0 ŸYm (Bands 29, 31, and 32). Optimum Red-Green-Blue false color composite images were developed to provide information on ash cloud location, as well as cloud phase and surface characteristics, to aid in interpretation both day and night. Information on volcanic ash derived from the tri-spectral product was displayed using the red color gun. This information was combined with visible (0.6 ŸYm) and near-IR (1.6 ŸYm) data for green and blue, respectively, during daylight periods. At night, the 8.6 ­V 11.0 ŸYm combination and 11.0 ŸYm band were used for the green and blue colors in the RGB product. Currently, raw MODIS data in five minute ­granules­" are processed for the following regions: (1) southern Alaska, (2) Mexico, Central America and the Caribbean, and (3) northern Andes region of South America. Image products are converted to Geo-spatial Information System (GIS) compatible formats for use in the HMS, and to Man-Computer Interactive Data Access System (McIDAS) ­Area File­" format for use in currently configured W-VAAC display systems. The installation of a high speed, fiber optic line from NASA Goddard Space Flight Center to the World

  4. Torsionally Excited Dimethyl Ether in the Laboratory and in Space

    NASA Astrophysics Data System (ADS)

    Endres, C. P.; Müller, H. S. P.; Lewen, F.; Giesen, T. F.; Schlemmer, S.; Drouin, B. J.; Bisschop, S.; Groner, P.

    2010-06-01

    Dimethyl ether (DME) is highly abundant in hot cores and numerous transitions within the vibrational ground state have been detected in various interstellar line surveys of sources such as Orion KL. As a nearly prolate asymmetric top with two internal rotors, it shows a complex spectrum with low lying torsional modes. The energy levels of the two lowest torsional states (v11, and v15) lie only 200 and 240 cm-1 above the ground state (barrier height ≈ 915 cm-1), and are thus sufficiently populated in these interstellar sources to exhibit transitions in line surveys due to high excitation temperatures in hot cores. So far, the lack of sufficiently accurate predictions for the two lowest excited torsional states prevented their identification in astronomical spectra. Therefore, we analyzed spectra, which have been recorded within the context of the investigations of the ground state. In total, more than 9500 transitions have been assigned covering the frequency range from 38 up to 1670 GHz. The enlarged splitting of each rotational level into four substates (AA, EE, AE, EA) compared to its size in the ground state and a large number of perturbed transitions hampered not only the line assignment but also the astrophysical modelling. However, the inclusion of interaction terms between both excited states in the model of an effective Hamiltonian for a symmetric two-top rotor, allowed us to model both excited states within a global fit, and also to accurately determine the energy difference between both states. Frequency predictions have been calculated based on this analysis and have been used to unambiguously assign numerous rotational transitions within these excited states in the astronomical line survey of the hot core region G327.3-0.6. P. Schilke, T.D. Groesbeck et al., Astrophys.J.Suppl.Ser., 108,(1997) 301-337 P. Schilke, D.J. Benford, T.R. Hunter et al., Astrophys.J.Suppl.Ser., 132,(2001) 281-364. P. Groner, S. Albert, E. Herbst, and F.C. De Lucia, Astrophys

  5. Plasma free choline, betaine and cognitive performance: the Hordaland Health Study.

    PubMed

    Nurk, Eha; Refsum, Helga; Bjelland, Ingvar; Drevon, Christian A; Tell, Grethe S; Ueland, Per M; Vollset, Stein E; Engedal, Knut; Nygaard, Harald A; Smith, David A

    2013-02-14

    Choline and betaine are nutrients involved in one-carbon metabolism. Choline is essential for neurodevelopment and brain function. We studied the associations between cognitive function and plasma concentrations of free choline and betaine. In a cross-sectional study, 2195 subjects (55 % women), aged 70-74 years, underwent extensive cognitive testing including the Kendrick Object Learning Test (KOLT), Trail Making Test (part A, TMT-A), modified versions of the Digit Symbol Test (m-DST), Block Design (m-BD), Mini-Mental State Examination (m-MMSE) and Controlled Oral Word Association Test (COWAT). Compared with low concentrations, high choline (>8·4 μmol/l) was associated with better test scores in the TMT-A (56·0 v. 61·5, P=0·004), m-DST (10·5 v. 9·8, P=0·005) and m-MMSE (11·5 v. 11·4, P=0·01). A generalised additive regression model showed a positive dose-response relationship between the m-MMSE and choline (P=0·012 from a corresponding linear regression model). Betaine was associated with the KOLT, TMT-A and COWAT, but after adjustments for potential confounders, the associations lost significance. Risk ratios (RR) for poor test performance roughly tripled when low choline was combined with either low plasma vitamin B₁₂ (≤257 pmol/l) concentrations (RR(KOLT)=2·6, 95 % CI 1·1, 6·1; RR(m-MMSE)=2·7, 95 % CI 1·1, 6·6; RR(COWAT)=3·1, 95 % CI 1·4, 7·2) or high methylmalonic acid (MMA) (≥3·95 μmol/l) concentrations (RR(m-BD)=2·8, 95 % CI 1·3, 6·1). Low betaine (≤31·1 μmol/l) combined with high MMA was associated with elevated RR on KOLT (RR(KOLT)=2·5, 95 % CI 1·0, 6·2). Low plasma free choline concentrations are associated with poor cognitive performance. There were significant interactions between low choline or betaine and low vitamin B₁₂ or high MMA on cognitive performance. PMID:22717142

  6. Metamorphic manipulating mechanism design for MCCB using index reduced iteration

    NASA Astrophysics Data System (ADS)

    Xu, Jinghua; Zhang, Shuyou; Zhao, Zhen; Lin, Xiaoxia

    2013-03-01

    The present research on moulded case circuit breaker(MCCB) focuses on the enhancement of current-limiting interrupting performance during short circuit, overload, under voltage and phase failure, involving electrics, magnetic, mechanics, thermal, material, friction, arc extinguishing, impact vibration, skin effect, etc. The rigid-flexible coupling of the parts and components of the metamorphic manipulating mechanism in multi-fields leads to the non-rigid, high frequency, high damping, singularity of the Euler-Lagrange equations which represents the multi-body dynamics. The small step iteration which is used for obtaining the instantaneous and short time critical interrupting performance of metamorphic mechanism appears inaccuracy. It is difficult to realize top-down design by existing CAD systems. Therefore, a metamorphic manipulating mechanism design method for MCCB using index reduced iteration(IRI) is put forward. The metamorphic manipulating mechanism of MCCB is decomposed into three mechanisms: main switch connector mechanism, electromagnet-drawbar-jump buckle mechanism, and bimetallic strip-drawbar mechanism, which is respectively described by electro-dynamic force, electromagnet force, and bimetallic strip force. The dummy part(virtual rigid) without moment of inertia and mass is employed as intermediate to join the flexible body and rigid body. The model of rigid-flexible coupling metamorphic mechanism multi-body dynamics is built. The differential algebraic equations(DAEs) of the multibody dynamics model are converted to pure ordinary differential equations(ODEs) by coordinate partition. Order reduced integration with multi-step and variable step-size is preceded based on IRI. The non-linear algebraic equations are solved in each integration step by Newton-Rapson iteration. There is no ill-condition and singularity of Jacobian matrix when step size reduces to zero. The independent prototype design system using ACIS R13, HOOPS V11.0 and Visual C++.NET 2003

  7. Physical parameters of NGC6705 (M11) open cluster using Strömgren photometry

    NASA Astrophysics Data System (ADS)

    Casamiquela, L.; Balaguer-Núñez, L.; Jordi, C.; Masana, E.

    2015-05-01

    NGC 6705 (M11) is a middle-age well-studied open cluster. Its location in an area where the interstellar extinction is relatively low, its exceptional stellar density and richness, and the presence of both early type and evolved stars makes this cluster an interesting target for many scientific issues. Although NGC 6705 has been widely studied, Strömgren photometry was missing. The observations by our team have yielded uvbyH photometry for 51293 stars in an area of 34'×34' and with V_{lim}˜21. Observed stars with complete photometry (9308) are classified into photometric regions and their physical parameters are determined using standard relations among color indices for each of the photometric regions of the HR diagram. That allows us to provide an astrophysical characterization of the cluster: E(b-y)=0.31±0.05 (E(B-V)=0.42); V_{0}-M_{V}=11.9±0.7 (d˜2000pc); [Fe/H]=-0.2±0.4 (Z=0.009). In addition, we discuss the accuracy of the physical parameters through comparison with those recently determined by Beaver et al. (2013) with Strömgren photometry. We find mean systematic differences of Δ V=-0.015±0.038, Δ (b-y)=-0.017±0.046, Δ m_{1}=-0.014±0.092, Δ c_{1}=+0.014±0.131, and Δ β=-0.036±0.042. These are caused by different selection of reference stars for the instrumental-to-standard transformation. We also compare our results with those from the spectroscopic Gaia-ESO Survey (GES) to assess the quality of the photometric determinations. This work can be useful to give input astrophysical parameters to the spectral analyses being made by GES. We find out clear different trends for the stars bluer and redder than (b-y)=0.4 (T_{eff}˜8000 K), due to the different instrumental setups used for the GIRAFFE observations (HR3 and HR15N). We find that mean differences in effective temperatures and gravities for both works are compatible within the errors. However, mean difference in metallicity for stars with (b-y)>0.4 is discrepant by -0.65 dex.

  8. Hydrothermal Alteration Mapping Studies for Geothermal Energy Exploration

    NASA Astrophysics Data System (ADS)

    Calvin, W. M.; Kratt, C.; Littlefield, E. F.; Lamb, A. K.

    2011-12-01

    V11C-2528_T1.jpg">

  9. Comparing the Effects of Echinophora-platyloba, Fennel and Placebo on Pre-menstrual Syndrome

    PubMed Central

    Delaram, Masoumeh; Kheiri, Soleiman; Hodjati, Mohammad Reza

    2011-01-01

    Introduction Premenstrual syndrome (PMS) is a condition characterized by a number of behavioral, psychological and physical symptoms recurring cyclically during the luteal phase of the menstrual cycle. The uncertainty in the pathogenesis of PMS has led to many treatment protocols being suggested as possible therapies. The present study was carried out to compare the effects of echinophora-platyloba and fennel extracts on the PMS against placebo in students of Shahrekord University of Medical Sciences in 2008. Methods In this single-blind randomized clinical trial, 90 students with moderate to severe PMS enrolled in the study and were randomely divided into three equal groups. The first group received echinophora-platyloba extract, the second group received fennel extracts and the third group received placebo. The severity of PMS was measured by Daily Record of Severity of Problems (DRSP) questionnaire at the end of the first and second menstrual cycles before the intervention and the results were compared with them after the intervention. Data was analyzed using Dunn, Kruskal Wallis, and Pearson correlation tests by SPSS (v. 11.5) and p < 0.05 was considered statistically significant. Results There were not any significant differences in the means of premenstrual syndrome scores before the intervention among the three groups (100.8±22.1 in echinophora-platyloba group, 101.3±27.1 in fennel group and 104.3±19.5 in placebo group, p > 0.05), but the differences were significant after the intervention (49.7±23.2 in echinophora-platyloba group, 64.4±27.5 in fennel group and 79.1±28.1 in placebo group, respectively, p < 0.001). No significant differences were seen between the echinophora-platyloba and fennel groups. Conclusion The echinophora-platyloba and fennel extracts could reduce the severity of PMS. The effects of echinophora-platyloba and fennel were similar and greater than the placebo. Administration of the extracts of these herbs is suggested for relieving

  10. The Besançon Galaxy model renewed. I. Constraints on the local star formation history from Tycho data

    NASA Astrophysics Data System (ADS)

    Czekaj, M. A.; Robin, A. C.; Figueras, F.; Luri, X.; Haywood, M.

    2014-04-01

    Context. The understanding of Galaxy evolution can be facilitated by the use of population synthesis models, which allows us to test hypotheses on the star formation history, star evolution, and chemical and dynamical evolution of the Galaxy. Aims: The new version of the Besançon Galaxy model (BGM) aims to provide a more flexible and powerful tool to investigate the initial mass function (IMF) and star formation rate (SFR) of the Galactic disc. Methods: We present a new strategy for the generation of thin disc stars, which assumes the IMF, SFR and evolutionary tracks as free parameters. We have updated most of the ingredients for the star count production and, for the first time, binary stars are generated in a consistent way. The local dynamical self-consistency is maintained in this new scheme. We then compare simulations from the new model with Tycho-2 data and the local luminosity function, as a first test to verify and constrain the new ingredients. The effects of changing thirteen different ingredients of the model are systematically studied. Results: For the first time, a full sky comparison is performed between BGM and data. This strategy allows us to constrain the IMF slope at high masses, which is found to be close to 3.0 and excludes a shallower slope such as Salpeter's one. The SFR is found decreasing whatever IMF is assumed. The model is compatible with a local dark matter density of 0.011 M⊙ pc-3 implying that there is no compelling evidence for the significant amount of dark matter in the disc. While the model is fitted to Tycho-2 data, which is a magnitude limited sample with V< 11, we check that it is still consistent with fainter stars. Conclusions: The new model constitutes a new basis for further comparisons with large scale surveys and is being prepared to become a powerful tool for the analysis of the Gaia mission data. Appendices are available in electronic form at http://www.aanda.org

  11. Hubble space telescope observations of young star clusters in NGC-4038/4039, 'the antennae' galaxies

    NASA Technical Reports Server (NTRS)

    Whitmore, Bradley C.; Schweizer, Francois

    1995-01-01

    New, high-resolution images of the disks of NGC 4038/4039 obtained with the Wide Field Camera of the Hubble Space Telescope (HST) are presented. NGC 4038/4039, nicknamed The Antennae, is a prototypical example of a pair of colliding galaxies believed to be at an early stage of a merger. Down to the limiting magnitude of V approximately 23 mag, the HST images reveal a population of over 700 blue pointlike objects within the disks. The mean absolute magnitude of these objects is M(sub V) = -11 mag, with the brightest objects reaching M(sub V) approximately -15. Their mean apparent color indices ar U - V = -0.7 mag and V - 1 = 0.8 mag on the Johnson UVI passband system, while their mean indices corrected for internal reddening are (u - v)(sub 0) = -1.0 mag and (V - I(sub 0) = 0.5. Their mean effective radius, determined from slightly resolved images, is 18 pc (for H(sub 0) = 50 km/s /Mpc). Based on their luminosities and resolution, most of these objects cannot be individual stars, but are likely young compact star clusters. The brighter ones are similar to the objects found in NGC 1275 and NGC 7252, which appear to be young globular clusters formed during recent galazy mergers. Based on their U - V and V - I colors, the brightest, bluest clusters of NGC 4038/4039 appear to be less than 10 Myr old. Most of these bright clusters are relatively tightly clustered themselves, with typically a dozen individual clusters belonging to a complex identified as a giant H II region from ground-based observations. The cluster luminosity function (LF) is approximately a power law, phi(L)dL proportional to L(exp -1.78+/-0.05)dL, with no hint of a turnover at fainter magnitudes. This power-law shape agrees with the LF of Magellanic Cloud clusters and Galactic open clusters, but differs from the LF of old globular cluster systems that is typically Gaussian with a Full Width at Half Maximum (FWHM) of approximately 3 mag. Besides the blue clusters, we also find about a dozen extremely

  12. Bayesian investigation of isochrone consistency using the old open cluster NGC 188

    SciTech Connect

    Hills, Shane; Courteau, Stéphane; Von Hippel, Ted; Geller, Aaron M. E-mail: courteau@astro.queensu.ca E-mail: a-geller@northwestern.edu

    2015-03-01

    This paper provides a detailed comparison of the differences in parameters derived for a star cluster from its color–magnitude diagrams (CMDs) depending on the filters and models used. We examine the consistency and reliability of fitting three widely used stellar evolution models to 15 combinations of optical and near-IR photometry for the old open cluster NGC 188. The optical filter response curves match those of theoretical systems and are thus not the source of fit inconsistencies. NGC 188 is ideally suited to this study thanks to a wide variety of high-quality photometry and available proper motions and radial velocities that enable us to remove non-cluster members and many binaries. Our Bayesian fitting technique yields inferred values of age, metallicity, distance modulus, and absorption as a function of the photometric band combinations and stellar models. We show that the historically favored three-band combinations of UBV and VRI can be meaningfully inconsistent with each other and with longer baseline data sets such as UBVRIJHK{sub S}. Differences among model sets can also be substantial. For instance, fitting Yi et al. (2001) and Dotter et al. (2008) models to UBVRIJHK{sub S} photometry for NGC 188 yields the following cluster parameters: age = (5.78 ± 0.03, 6.45 ± 0.04) Gyr, [Fe/H] = (+0.125 ± 0.003, −0.077 ± 0.003) dex, (m−M){sub V} = (11.441 ± 0.007, 11.525 ± 0.005) mag, and A{sub V} = (0.162 ± 0.003, 0.236 ± 0.003) mag, respectively. Within the formal fitting errors, these two fits are substantially and statistically different. Such differences among fits using different filters and models are a cautionary tale regarding our current ability to fit star cluster CMDs. Additional modeling of this kind, with more models and star clusters, and future Gaia parallaxes are critical for isolating and quantifying the most relevant uncertainties in stellar evolutionary models.

  13. Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling.

    PubMed

    Sears, Claire E; Bryant, Simon M; Ashley, Euan A; Lygate, Craig A; Rakovic, Stevan; Wallis, Helen L; Neubauer, Stefan; Terrar, Derek A; Casadei, B

    2003-03-21

    A neuronal isoform of nitric oxide synthase (nNOS) has recently been located to the cardiac sarcoplasmic reticulum (SR). Subcellular localization of a constitutive NOS in the proximity of an activating source of Ca2+ suggests that cardiac nNOS-derived NO may regulate contraction by exerting a highly specific and localized action on ion channels/transporters involved in Ca2+ cycling. To test this hypothesis, we have investigated myocardial Ca2+ handling and contractility in nNOS knockout mice (nNOS-/-) and in control mice (C) after acute nNOS inhibition with 100 micromol/L L-VNIO. nNOS gene disruption or L-VNIO increased basal contraction both in left ventricular (LV) myocytes (steady-state cell shortening 10.3+/-0.6% in nNOS-/- versus 8.1+/-0.5% in C; P<0.05) and in vivo (LV ejection fraction 53.5+/-2.7 in nNOS-/- versus 44.9+/-1.5% in C; P<0.05). nNOS disruption increased ICa density (in pA/pF, at 0 mV, -11.4+/-0.5 in nNOS-/- versus -9.1+/-0.5 in C; P<0.05) and prolonged the slow time constant of inactivation of ICa by 38% (P<0.05), leading to an increased Ca2+ influx and a greater SR load in nNOS-/- myocytes (in pC/pF, 0.78+/-0.04 in nNOS-/- versus 0.64+/-0.03 in C; P<0.05). Consistent with these data, [Ca2+]i transient (indo-1) peak amplitude was greater in nNOS-/- myocytes (410/495 ratio 0.34+/-0.01 in nNOS-/- versus 0.31+/-0.01 in C; P<0.05). These findings have uncovered a novel mechanism by which intracellular Ca2+ is regulated in LV myocytes and indicate that nNOS is an important determinant of basal contractility in the mammalian myocardium. The full text of this article is available at http://www.circresaha.org. PMID:12623875

  14. Skin dose differences between intensity-modulated radiation therapy and volumetric-modulated arc therapy and between boost and integrated treatment regimens for treating head and neck and other cancer sites in patients.

    PubMed

    Penoncello, Gregory P; Ding, George X

    2016-01-01

    The purpose of this study was (1) to evaluate dose to skin between volumetric-modulated arc therapy (VMAT) and intensity-modulated radiation therapy (IMRT) treatment techniques for target sites in the head and neck, pelvis, and brain and (2) to determine if the treatment dose and fractionation regimen affect the skin dose between traditional sequential boost and integrated boost regimens for patients with head and neck cancer. A total of 19 patients and 48 plans were evaluated. The Eclipse (v11) treatment planning system was used to plan therapy in 9 patients with head and neck cancer, 5 patients with prostate cancer, and 5 patients with brain cancer with VMAT and static-field IMRT. The mean skin dose and the maximum dose to a contiguous volume of 2cm(3) for head and neck plans and brain plans and a contiguous volume of 5cm(3) for pelvis plans were compared for each treatment technique. Of the 9 patients with head and neck cancer, 3 underwent an integrated boost regimen. One integrated boost plan was replanned with IMRT and VMAT using a traditional boost regimen. For target sites located in the head and neck, VMAT reduced the mean dose and contiguous hot spot most noticeably in the shoulder region by 5.6% and 5.4%, respectively. When using an integrated boost regimen, the contiguous hot spot skin dose in the shoulder was larger on average than a traditional boost pattern by 26.5% and the mean skin dose was larger by 1.7%. VMAT techniques largely decrease the contiguous hot spot in the skin in the pelvis by an average of 36% compared with IMRT. For the same target coverage, VMAT can reduce the skin dose in all the regions of the body, but more noticeably in the shoulders in patients with head and neck and pelvis cancer. We also found that using integrated boost regimens in patients with head and neck cancer leads to higher shoulder skin doses compared with traditional boost regimens. PMID:26764180

  15. The effect of empowerment on the self-efficacy, quality of life and clinical and laboratory indicators of patients treated with hemodialysis: a randomized controlled trial

    PubMed Central

    2012-01-01

    Background Hemodialysis patients face numerous physical and psychological stresses that result in reduced health. The aim of this study is to determine the impact of an empowerment program on self-efficacy, quality of life, clinical indicators of blood pressure and interdialytic weight gain, and laboratory results in these patients. Methods This randomized, controlled trial was conducted at Boo Ali Sina Dialysis Center, Shiraz, Iran. A total of 48 hemodialysis patients participated in this study. After acquisition of informed consent, eligible patients were randomly divided into two groups, control and experimental. Pre-test data were obtained by using a demographic data form and two questionnaires for self-efficacy and quality of life. Blood pressure and interdialytic weight gain were measured. We extracted laboratory data from patients’ charts. A six-week empowerment intervention that included four individual and two group counselling sessions was performed for the experimental group. Six weeks after intervention, post-test data were obtained from both groups in the same manner as the pre-test. Data were analyzed by ANCOVA using SPSS v11.5. Results There were no statistically significant differences in demographic variables between the groups. Pre-test mean scores for self-efficacy, quality of life, blood pressure, interdialytic weight gain and laboratory results did not differ between the groups. There was a significant difference between the experimental and control groups in terms of pre-to post-intervention changes in overall self-efficacy scores, stress reduction, and decision making, in addition to overall quality of life and all dimensions included within quality of life based on this questionnaire. Additionally, the pre- to post-intervention changes in systolic/diastolic blood pressures, interdialytic weight gain, hemoglobin and hematocrit levels significantly differed between the groups. Conclusion Our study demonstrates that a combination of

  16. Detection and characterization of viruses as field and vaccine strains in feedlot cattle with bovine respiratory disease.

    PubMed

    Fulton, R W; d'Offay, J M; Landis, C; Miles, D G; Smith, R A; Saliki, J T; Ridpath, J F; Confer, A W; Neill, J D; Eberle, R; Clement, T J; Chase, C C L; Burge, L J; Payton, M E

    2016-06-24

    This study investigated viruses in bovine respiratory disease (BRD) cases in feedlots, including bovine herpesvirus-1 (BoHV-1), bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV), bovine coronaviruses (BoCV) and parainfluenza-3 virus (PI3V). Nasal swabs were collected from 114 cattle on initial BRD treatment. Processing included modified live virus (MLV) vaccination. Seven BRD necropsy cases were included for 121 total cases. Mean number of days on feed before first sample was 14.9 days. Swabs and tissue homogenates were tested by gel based PCR (G-PCR), quantitative-PCR (qPCR) and quantitative real time reverse transcriptase PCR (qRT-PCR) and viral culture. There were 87/114 (76.3%) swabs positive for at least one virus by at least one test. All necropsy cases were positive for at least one virus. Of 121 cases, positives included 18/121 (14.9%) BoHV-1; 19/121 (15.7%) BVDV; 76/121 (62.8%) BoCV; 11/121 (9.1%) BRSV; and 10/121 (8.3%) PI3V. For nasal swabs, G-PCR (5 viruses) detected 44/114 (38.6%); q-PCR and qRT-PCR (4 viruses) detected 81/114 (71.6%); and virus isolation detected 40/114 (35.1%). Most were positive for only one or two tests, but not all three tests. Necropsy cases had positives: 5/7 G-PCR, 5/7 q-PCR and qRT-PCR, and all were positive by cell culture. In some cases, G-PCR and both real time PCR were negative for BoHV-1, BVDV, and PI3V in samples positive by culture. PCR did not differentiate field from vaccines strains of BoHV-1, BVDV, and PI3V. However based on sequencing and analysis, field and vaccine strains of culture positive BoHV-1, BoCV, BVDV, and PI3V, 11/18 (61.1%) of BoHV-1 isolates, 6/17 (35.3%) BVDV isolates, and 1/10 (10.0%) PI3V identified as vaccine. BRSV was only identified by PCR testing. Interpretation of laboratory tests is appropriate as molecular based tests and virus isolation cannot separate field from vaccine strains. Additional testing using sequencing appears appropriate for identifying vaccine

  17. Oral delivery systems for encapsulated bacteriophages targeted at Escherichia coli O157:H7 in feedlot cattle.

    PubMed

    Stanford, K; McAllister, T A; Niu, Y D; Stephens, T P; Mazzocco, A; Waddell, T E; Johnson, R P

    2010-07-01

    Bacteriophages are natural predators of bacteria and may mitigate Escherichia coli O157:H7 in cattle and their environment. As bacteriophages targeted to E. coli O157:H7 (phages) lose activity at low pH, protection from gastric acidity may enhance efficacy of orally administered phages. Polymer encapsulation of four phages, wV8, rV5, wV7, and wV11, and exposure to pH 3.0 for 20 min resulted in an average 13.6% recovery of phages after release from encapsulation at pH 7.2. In contrast, untreated phages under similar conditions had a complete loss of activity. Steers (n = 24) received 10(11) CFU of naladixic acid-resistant E. coli O157:H7 on day 0 and were housed in six pens of four steers. Two pens were control (naladixic acid-resistant E. coli O157:H7 only), and the remaining pens received polymer-encapsulated phages (Ephage) on days -1, 1, 3, 6, and 8. Two pens received Ephage orally in gelatin capsules (bolus; 10(10) PFU per steer per day), and the remaining two pens received Ephage top-dressed on their feed (feed; estimated 10(11) PFU per steer per day). Shedding of E. coli O157:H7 was monitored for 10 weeks by collecting fecal grab and hide swab samples. Acceptable activity of mixed phages at delivery to steers was found for bolus and feed, averaging 1.82 and 1.13 x 10(9) PFU/g, respectively. However, Ephage did not reduce shedding of naladixic acid-resistant E. coli O157:H7, although duration of shedding was reduced by 14 days (P < 0.1) in bolus-fed steers as compared with control steers. Two successful systems for delivery of Ephage were developed, but a better understanding of phage-E. coli O157:H7 ecology is required to make phage therapy a viable strategy for mitigation of this organism in feedlot cattle. PMID:20615343

  18. SU-F-BRE-10: Methods to Simulate and Measure the Attenuation for Modeling a Couch Top with Rails for FFF Treatment Delivery On the Varian Edge Linac

    SciTech Connect

    Gulam, M; Gardner, S; Zhao, B; Snyder, K; Song, K; Li, H; Gordon, J; Wen, N; Chetty, I; Kearns, W

    2014-06-15

    Purpose: To measure attenuation for modelling of the KVue Couchtop for 6X and 10X FFF SRS/SBRT treatment Methods: Treatment planning simulation studies were done using 6X FFF beams to estimate the dosimetric impact of KVue couchtops (including the Q-Fix IGRT [carbon fiber] and Calypso [nonconductive Kevlar material]) with a structure model obtained from a research workstation (Eclipse, advanced planning interface (API) v13). Prior to installation on the Varian Edge linac, the couchtop along with (Kevlar) rails were CT scanned with the rails at various positions. An additional scan with the couchtop 15cm above the CT table top was obtained with 20cm solid water to facilitate precised/indexed data acquisition. Measurements for attenuation were obtained for field sizes of 2, 4 and 10 cm{sup 2} at 42 gantry angles including 6 pairs of opposing fields and other angles for oblique delivery where the beams traversed the couchtop and or rails. The delivery was fully automated with xml scripts running in developer mode. The results were then used to determine an accurate structure model for AAA (Eclipse v11) planning of IMRT and RapidArc delivery. Results: The planning simulation relative dose attenuation for oblique entry was not significantly different than the Exact IGRT or BrainLab iBeam couch except that the rails added 6% additional attenuation. The relative attenuation measurements for PA, PA (rails: inner position), oblique, oblique (rails: outer position), oblique (rails: inner position) were: −2.0%, −2.5%, −15.6%, −2.5%, −5.0% for 6X FFF and −1.4%, −1.5%, −12.2%, − 2.5%, −5.0% for 10X FFF with slight decrease in attenuation versus field size. A Couch structure model (with HU values) was developed. Calculation compared to measurement showed good agreement except for oblique (rails: outer position) where differences approached a magnitude of 6%. Conclusion: A model of the couch structures has been developed accounting for attenuation for FFF

  19. KELT-10b: the first transiting exoplanet from the KELT-South survey - a hot sub-Jupiter transiting a V = 10.7 early G-star

    NASA Astrophysics Data System (ADS)

    Kuhn, Rudolf B.; Rodriguez, Joseph E.; Collins, Karen A.; Lund, Michael B.; Siverd, Robert J.; Colón, Knicole D.; Pepper, Joshua; Stassun, Keivan G.; Cargile, Phillip A.; James, David J.; Penev, Kaloyan; Zhou, George; Bayliss, Daniel; Tan, T. G.; Curtis, Ivan A.; Udry, Stephane; Segransan, Damien; Mawet, Dimitri; Dhital, Saurav; Soutter, Jack; Hart, Rhodes; Carter, Brad; Gaudi, B. Scott; Myers, Gordon; Beatty, Thomas G.; Eastman, Jason D.; Reichart, Daniel E.; Haislip, Joshua B.; Kielkopf, John; Bieryla, Allyson; Latham, David W.; Jensen, Eric L. N.; Oberst, Thomas E.; Stevens, Daniel J.

    2016-07-01

    We report the discovery of KELT-10b, the first transiting exoplanet discovered using the KELT-South telescope. KELT-10b is a highly inflated sub-Jupiter mass planet transiting a relatively bright V = 10.7 star (TYC 8378-64-1), with Teff = 5948 ± 74 K, log g = 4.319_{-0.030}^{+0.020} and [Fe/H] = 0.09_{-0.10}^{+0.11}, an inferred mass M* = 1.112_{-0.061}^{+0.055} M⊙ and radius R* = 1.209_{-0.035}^{+0.047} R⊙. The planet has a radius Rp = 1.399_{-0.049}^{+0.069} RJ and mass Mp = 0.679_{-0.038}^{+0.039} MJ. The planet has an eccentricity consistent with zero and a semimajor axis a = 0.052 50_{-0.000 97}^{+0.000 86} au. The best-fitting linear ephemeris is T0 = 2457 066.720 45 ± 0.000 27 BJDTDB and P = 4.166 2739 ± 0.000 0063 d. This planet joins a group of highly inflated transiting exoplanets with a larger radius and smaller mass than that of Jupiter. The planet, which boasts deep transits of 1.4 per cent, has a relatively high equilibrium temperature of Teq = 1377_{-23}^{+28} K, assuming zero albedo and perfect heat redistribution. KELT-10b receives an estimated insolation of 0.817_{-0.054}^{+0.068} × 109 erg s-1 cm-2, which places it far above the insolation threshold above which hot Jupiters exhibit increasing amounts of radius inflation. Evolutionary analysis of the host star suggests that KELT-10b may not survive beyond the current subgiant phase, depending on the rate of in-spiral of the planet over the next few Gyr. The planet transits a relatively bright star and exhibits the third largest transit depth of all transiting exoplanets with V < 11 in the Southern hemisphere, making it a promising candidate for future atmospheric characterization studies.

  20. Basal-like molecular subtype and HER4 up-regulation and response to neoadjuvant chemotherapy in breast cancer.

    PubMed

    Stickeler, Elmar; Pils, Dietmar; Klar, Maximilian; Orlowsk-Volk, Marzenna; Zur Hausen, Axel; Jäger, Markus; Watermann, Dirk; Gitsch, Gerald; Zeillinger, Robert; Tempfer, Clemens B

    2011-10-01

    Alteration of gene expression profiles during chemotherapy may predict response to neoadjuvant chemotherapy (NAC) in breast cancer patients. In a prospective cohort study of 32 women with primary invasive breast cancer, we obtained tumor specimens before and after 4 cycles of NAC with epirubicine 90 mg/m2 and cyclophosphamide 600 mg/m2, followed by 4 cycles of docetaxel 100 mg/m2. Total-RNA was extracted from tumor specimens and the whole transcriptome was analyzed with Agilent's 44K single color microarray. Data analysis was performed by GeneSpring v.11 and IBM SPSS v.18. Ten tumors were classified as basal-like and 22 tumors were classified as non-basal-like. Gene expression-based molecular subtype (basal-like vs. non-basal-like) (P=0.003), but not tumor grade (P=0.07), estrogen receptor (P=0.1), progesterone receptor (P=0.6) and HER2 status (P=0.4) predicted pathological complete response to NAC. Specifically, 7/10 basal-like tumors responded to NAC, whereas 19/22 non-basal-like tumors did not respond. Comparing gene expression signatures before and after 4 cycles of NAC, we found that all patients with an initial non-basal-like tumor retained this tumor type, whereas 5/7 basal-like tumors, including all responders, lost this molecular subtype. Complete prediction of response to NAC was achieved with a 21 gene list (P=0.000008). Of note, both the expression and up-regulation of a single gene, i.e. HER4, predicted the response to NAC in 26/32 (81%; P=0.002) and in 23/25 (92%; P<0.001) patients, respectively. These preliminary data indicate that therapy-induced HER4 gene up-regulation may be associated with response to NAC with epirubicine, cyclophosphamide and docetaxel. PMID:21769435

  1. Risk Factors of Carbapenem-Resistant Klebsiella pneumoniae Infection: A Serious Threat in ICUs

    PubMed Central

    Ulu, Aslıhan Candevir; Kurtaran, Behice; Inal, Ayşe Seza; Kömür, Süheyla; Kibar, Filiz; Çiçekdemir, Hatice Yapıcı; Bozkurt, Seval; Gürel, Derya; Kılıç, Fatma; Yaman, Akgün; Aksu, Hasan Salih Zeki; Taşova, Yeşim

    2015-01-01

    Background Nosocomial infections caused by Carbapenem-resistant Klebsiella pneumoniae (CRKP) are increasing. Our aim in this study was to investigate the risk factors of CRKP infections. Material/Methods A retrospective cohort study was performed between 1 January and 31 December 2012 in ICU patients. Data was taken from the hospital infection control database for CRKP. The clinical samples collected from the patients were tested by an automatized system and disk diffusion. SPSS software v11.5 was used for statistical analysis. Results Totally, 105 Klebsiella pneumoniae isolates were found in 2012 and the carbapenem resistance rate was 48%. The first episode of infection was taken into risk factor analysis. Of the 98 patients, 61 (62.2%) were male and the mean and median ages were 30.4±29.8 and 25 (0–93). The length of stay was longer in the resistant group (p=0.026). Mortality was 48% in the whole group and similar between groups (p=0.533). There was a relationship between meropenem and third-generation cephalosporin use and resistance (OR 3.244 (1.193–8.819) and OR: 3.590 (1.056–12.209). The other risk factors in univariate analysis were: Immunosuppression OR: 2.186 (1.754–2.724), nasogastric catheter OR: 3.562 (1.317–9.634), peripheral arterial catheter OR: 2.545 (1.027–6.307), and being admitted to the neurosurgical unit OR: 4.324 (1.110–16.842). The multivariate analysis showed use of third-generation cephalosporin OR: 4.699 (1.292–17.089), nasogastric catheter use OR: 3.983 (1.356–11.698), and being admitted to neurosurgical ICU OR: 4.603 (1.084–19.555) as independent risk factors. Conclusions Restriction of third-generation cephalosporin and carbapenem use and invasive procedures, along with infection control precautions and disinfection policies, may be effective in reducing the carbapenem resistance in ICUs. PMID:25595166

  2. Fine-grained data assimilation algorithm with uncertainty assessment in variational modeling technology

    NASA Astrophysics Data System (ADS)

    Penenko, Alexey; Penenko, Vladimir; Tsvetova, Elena

    2013-04-01

    RAS, by RFBR project 11-01-00187 and Integrating projects of SD RAS No 8 and 35. Our studies are in the line with the goals of COST Action ES1004. References: V. V. Penenko. Variational methods of data assimilation and inverse problems for studying the atmosphere, ocean, and environment // Numerical Analysis and Applications, 2009, V. 2, No 4, 341-351. V. Penenko, A.Baklanov, E. Tsvetova and A. Mahura. Direct and Inverse Problems in a Variational Concept of Environmental Modeling // Pure Appl. Geophys . DOI: 10.1007/s00024-011-0380-5, (2012) 169: 447-465. A. Penenko. Some theoretical and applied aspects of sequential variational data assimilation // Comp. tech. v.11, Part 2, (2006) 35-40 (In Russian).

  3. Hadron Production and Freeze-Out Dynamics at square root of sNN = 3.0 GeV Au+Al and square root of sNN = 19.6 GeV Au+Au Collisions as Measured at STAR

    NASA Astrophysics Data System (ADS)

    Brovko, Samantha Gail

    The Beam Energy Scan program at RHIC was commissioned to search for the critical point and the turn-off of QGP signatures. The program has completed collisions of Au+Au at energies from 7.7 to 62.4 GeV per nucleon pair in 2010 and 2011. The addition of a full-coverage Time-of-Flight detector at STAR extended the momentum range for clean particle identification. Mid-rapidity (|y| < 0.5) hadron spectra will be used to determine the freeze-out dynamics of the system. Particle spectra for pi, K, p and p¯ as a function of mT -- m0 will be presented and these will be used to discuss in particular the source's Coulombic effect on soft pions, as well as three of the four signs of the onset of deconfinement: the "Kink," the "Horn," and the "Step." Comparisons will be made to √s NN) = 7.7 GeV, 11.5 GeV, 19.6 GeV (from 2001), 27 GeV, 39 GeV Au+Au data from STAR, and (sqrt of sNN = 17.3 GeV Pb+Pb data from the SPS heavy ion program. Collisions between gold ions in the RHIC beam with aluminum nuclei in the beam pipe allow us to analyze fixed-target interactions with the STAR detector at RHIC. These lower-energy fixed-target collisions may allow us to extend the low-energy reach of the RHIC beam energy scan and possibly improve the chance of finding the critical point of the hadronic to quark matter phase boundary. In this thesis, we will present preliminary results of spectra analyses for a fixed target collision system at √sNN)= 3.0 GeV and colliding beam system at √sNN = 19.6 GeV . Also, the viability of doing fixed-target experiments with a collider detector will be discussed. Comparisons to simulation, using UrQMD, will also be made. The analysis provides a good reference to study excitation functions of strangeness production, net baryon number, and collective flow in heavy-ion collisions.

  4. Electromagnetic Safety of Spacecraft During Active Experiments with the Use of Plasma Accelerators and Ion Injectors

    NASA Astrophysics Data System (ADS)

    Plokhikh, Andrey; Popov, Garri; Shishkin, Gennady; Antropov, Nikolay; Vazhenin, Nikolay; Soganova, Galina

    electromagnetic emission of stationary and pulsed plasma injectors and of the electric propulsions developed on their basis are discussed. Predictive estimates are presented for the influence of originating electromagnetic fields and emissions on the electromagnetic safety of spacecraft and its systems and for the reliability of communication with ground command and tracking stations, and recommendations are given on the reduction of destructive effects. 1. S. Avdyushin, I. Podgorny, G. Popov, A. Porotnikov, "Plasma Accelerator Use for Studying Physical Processes in Space." Plasma Accelerators and Ion Injectors, Nauka, 1984. 2. A. Plokhikh, "Peculiarities of Radio Measurements in the Metal Vacuum Chambers." Vestnik moskovskogo aviatsionnogo instituta. v. 11, No. 2, 2004, pp. 66-78.

  5. SU-E-P-47: Evaluation of Improvement of Esophagus Sparing in SBRT Lung Patients with Biologically Based IMRT Optimization

    SciTech Connect

    Liang, X; Penagaricano, J; Paudel, N; Zhang, X; Morrill, S; Corry, P; Han, E; Hardee, M; Ratanatharathorn, V

    2015-06-15

    Purpose: To study the potential of improving esophageal sparing for stereotactic body radiation therapy (SBRT) lung cancer patients by using biological optimization (BO) compared to conventional dose-volume based optimization (DVO) in treatment planning. Methods: Three NSCLC patients (PTV (62.3cc, 65.1cc, and 125.1cc) adjacent to the heart) previously treated with SBRT were re-planned using Varian Eclipse TPS (V11) using DVO and BO. The prescription dose was 60 Gy in 5 fractions normalized to 95% of the PTV volume. Plans were evaluated by comparing esophageal maximum doses, PTV heterogeneity (HI= D5%/D95%), and Paddick’s conformity (CI) indices. Quality of the plans was assessed by clinically-used IMRT QA procedures. Results: By using BO, the maximum dose to the esophagus was decreased 1384 cGy (34.6%), 502 cGy (16.5%) and 532 cGy (16.2%) in patient 1, 2 and 3 respectively. The maximum doses to spinal cord and the doses to 1000 cc and 1500 cc of normal lung were comparable in both plans. The mean doses (Dmean-hrt) and doses to 15cc of the heart (V15-hrt) were comparable for patient 1 and 2. However for patient 3, with the largest PTV, Dmean-hrt and V15-hrt increased by 62.2 cGy (18.3%) and 549.9 cGy (24.9%) respectively for the BO plans. The mean target HI of BO plans (1.13) was inferior to the DVO plans (1.07). The same trend was also observed for mean CI in BO plans (0.77) versus DVO plans (0.83). The QA pass rates (3%, 3mm) were comparable for both plans. Conclusion: This study demonstrated that the use of biological models in treatment planning optimization can substantially improve esophageal sparing without compromising spinal cord and normal lung doses. However, for the large PTV case (125.1cc) we studied here, Dmean-hrt and V15-hrt increased substantially. The target HI and CI were inferior in the BO plans.

  6. SeReNA Project: studying aerosol interactions with cloud microphysics in the Amazon Basin

    NASA Astrophysics Data System (ADS)

    Correia, A. L.; Catandi, P. B.; Frigeri, F. F.; Ferreira, W. C.; Martins, J.; Artaxo, P.

    2012-12-01

    can influence them. Reference: Martins et al. (2011) ACP, v.11, p.9485-9501. Available at: http://bit.ly/martinspaper Figure 1. Brightness temperature (left panel) and thermodynamic phase (right) of hydrometeors in the convective cloud shown in the middle panel. Extracted from Martins et al. (2011).

  7. Impact of volcanism on the evolution of Lake Van (eastern Anatolia) III: Periodic (Nemrut) vs. episodic (Süphan) explosive eruptions and climate forcing reflected in a tephra gap between ca. 14 ka and ca. 30 ka

    NASA Astrophysics Data System (ADS)

    Schmincke, Hans-Ulrich; Sumita, Mari

    2014-09-01

    Fifteen Lateglacial to Holocene rhyolitic, dominantly primary tephra layers piston-cored and drilled (ICDP Paleovan drilling project) in western Lake Van (eastern Anatolia, Turkey) were precisely correlated to either of the two adjacent and active large volcanoes Nemrut and Süphan based on shard textures, mineralogy and mineral and glass compositions. The young peralkaline (comenditic to pantelleritic) primary rhyolitic Nemrut tephras are characterized by anorthoclase, hedenbergitic to augitic clinopyroxene, fayalitic olivine, minor quartz, and rare accessory chevkinite and zircon. Phenocrysts in subalkaline primary rhyolitic Süphan tephras are chiefly oligoclase-labradorite, with minor K-rich sanidine in some, biotite, amphibole, hypersthene, rare augitic clinopyroxene, relatively common allanite and rare zircon. Two contrasting explosive eruptive modes are distinguished from each other: episodic (Süphan) and periodic (Nemrut). The Lateglacial Süphan tephra swarm covers a short time interval of ca. 338 years between ca. 13,078 vy BP and 12,740 vy BP, eruptions having occurred statistically every ca. 42 years with especially short intervals between V-11 (reworked) and V-14. Causes for the strongly episodic Süphan explosive behavior might include seismic triggering of a volcano-magma system unable to erupt explosively without the benefit of external triggering, as reflected in pervasive faulting preceding the Süphan tephra swarm. Seismic triggering may have caused the rise of more mafic ("trachyandesitic") parent magma, heating near-surface pockets of highly evolved magma - that might have formed silicic domes during this stage of volcano evolution - resulting in ascent and finally explosive fragmentation of magma essentially by external factors, probably significantly enhanced by magma-water/ice interaction. Explosive eruptions of the Nemrut volcano system, interpreted to be underlain by a large fractionating magma reservoir, follow a more periodic mode of (a

  8. Cardiovascular and Metabolic Demads of the Kettlebell Swing using Tabata Interval versus a Traditional Resistance Protocol

    PubMed Central

    FORTNER, HOWARD A.; SALGADO, JEANETTE M.; HOLMSTRUP, ANGELICA M.; HOLMSTRUP, MICHAEL E.

    2014-01-01

    Tabata (TAB) training, consisting of eight cycles of 20 seconds of maximal exercise followed by 10 seconds of rest, is time-efficient, with aerobic and anaerobic benefit. This study investigated the cardiovascular and metabolic demands of a TAB versus traditional (TRAD) resistance protocol with the kettlebell swing. Fourteen young (18–25y), non-obese (BMI 25.7±0.8 kg/m2) participants reported on three occasions. All testing incorporated measurements of HR, oxygen consumption, and blood lactate accumulation. Each participant completed Tabata kettlebell swings (male- 8kg, female- 4.5kg; 8 intervals; 20s maximal repetitions, 10s rest). On a subsequent visit (TRAD), the total swings from the TAB protocol were evenly divided into 4 sets, with 90s rest between sets. Outcome measures were compared using paired t-tests. The TAB was completed more quickly than the TRAD protocol (240.0±0.0 v. 521.5±3.3 sec, P<0.01), at a higher perceived exertion (Borg RPE; 15.1±0.7 v. 11.7±0.9, P<0.01). The TAB elicited a higher average VO2 value (33.1±1.5 v. 27.2±1.6 ml/kg/min, P<0.01), percent of VO2peak achieved (71.0±0.3 v. 58.4±0.3%, P<0.01), maximal HR (162.4±4.6 v. 145.6±4.8 bpm, P<0.01), and post-exercise blood lactate concentration (6.4±1.1 v. 3.7±0.5 mmol/L, P<0.01). Conclusion The kettlebell swing demonstrated significantly greater cardiovascular and metabolic responses within a TAB vs. TRAD framework. Appropriate screening and risk stratification are advised before implementing kettlebell swings. PMID:27182402

  9. Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population.

    PubMed

    Jing, Chen; Xueyao, Han; Linong, Ji

    2012-10-01

    The multiple small-scale association studies of candidate genes for type 2 diabetes mellitus in the Chinese Han population have shown inconsistent results. Here, we performed a meta-analysis to evaluate the contribution of five candidate genes to the pathogenesis of type 2 diabetes in the Chinese Han population. We searched for relevant published papers and used STATA v.11.0 to perform a meta-analysis on six single-nucleotide polymorphisms in five genes-ADIPOQ-rs2241766 (SNP45) and -rs1501299 (SNP276), ADRB3-rs4994 (Trp64Arg), CAPN10-rs3792267 (SNP43), ENPP1-rs1044498 (K121Q), and PPARGC1A-rs8192678 (Gly482Ser)-in the Chinese Han population under an additive genetic model. The pooled odds ratios (95% confidence intervals and P-values) were 0.71 (0.60-0.83; P < 0.001) for ADIPOQ-rs2241766, 0.79 (0.64-0.97; P = 0.027) for ADIPOQ-rs1501299, 1.27 (1.07-1.51; P = 0.006) for ADRB3-rs4994, 0.79 (0.57-1.10; P = 0.163) for CAPN10-rs3792267, 1.41 (1.13-1.76; P = 0.003) for ENPP1-rs1044498, and 1.54 (1.34-1.81; P < 0.001) for PPARGC1A-rs8192678. There was high heterogeneity for ADIPOQ-rs2241766, ADIPOQ-rs1501299, and CAPN10-rs3792267 (I² = 74.9, 69.4, and 75.8%, respectively), but not for ADRB3-rs4994, ENPP1-rs1044498, and PPARGC1A-rs8192678 (I² = 0.0, 43.4, and 23.3%, respectively). Under an additive genetic model, the C allele of ADRB3-rs4994, the C allele of ENPP1-rs1044498, and the A allele of PPARGC1A-rs8192678 increase the risk of type 2 diabetes in the Chinese Han population. PMID:22391941

  10. Assessment of Polarization Effect on Efficiency of Levenberg-Marquardt Algorithm in Case of Thin Atmosphere over Black Surface

    NASA Astrophysics Data System (ADS)

    Korkin, S.; Lyapustin, A.

    2012-12-01

    The Levenberg-Marquardt algorithm [1, 2] provides a numerical iterative solution to the problem of minimization of a function over a space of its parameters. In our work, the Levenberg-Marquardt algorithm retrieves optical parameters of a thin (single scattering) plane parallel atmosphere irradiated by collimated infinitely wide monochromatic beam of light. Black ground surface is assumed. Computational accuracy, sensitivity to the initial guess and the presence of noise in the signal, and other properties of the algorithm are investigated in scalar (using intensity only) and vector (including polarization) modes. We consider an atmosphere that contains a mixture of coarse and fine fractions. Following [3], the fractions are simulated using Henyey-Greenstein model. Though not realistic, this assumption is very convenient for tests [4, p.354]. In our case it yields analytical evaluation of Jacobian matrix. Assuming the MISR geometry of observation [5] as an example, the average scattering cosines and the ratio of coarse and fine fractions, the atmosphere optical depth, and the single scattering albedo, are the five parameters to be determined numerically. In our implementation of the algorithm, the system of five linear equations is solved using the fast Cramer's rule [6]. A simple subroutine developed by the authors, makes the algorithm independent from external libraries. All Fortran 90/95 codes discussed in the presentation will be available immediately after the meeting from sergey.v.korkin@nasa.gov by request. [1]. Levenberg K, A method for the solution of certain non-linear problems in least squares, Quarterly of Applied Mathematics, 1944, V.2, P.164-168. [2]. Marquardt D, An algorithm for least-squares estimation of nonlinear parameters, Journal on Applied Mathematics, 1963, V.11, N.2, P.431-441. [3]. Hovenier JW, Multiple scattering of polarized light in planetary atmospheres. Astronomy and Astrophysics, 1971, V.13, P.7 - 29. [4]. Mishchenko MI, Travis LD

  11. Charged-particle induced radiation damage of a HPGe gamma-ray detector during spaceflight

    NASA Astrophysics Data System (ADS)

    Evans, L. G.; Starr, R.; Brückner, J.; Boynton, W. V.; Bailey, S. H.; Trombka, J. I.

    1999-02-01

    The Mars Observer spacecraft was launched on September 26, 1992 with a planned arrival at Mars after an 11-month cruise. Among the scientific instruments carried on the spacecraft was a Gamma-Ray Spectrometer (GRS) experiment to measure the composition of Mars. The GRS used a passively cooled high-purity germanium detector for measurements in the 0.2-10MeV region. The sensor was a closed-end co-axial detector, 5.5cm diameter by 5.5cm long, and had an efficiency along its axis of 28% at 1332keV relative to a standard NaI(Tl) detector. The sensor was surrounded by a thin (0.5cm) plastic charged-particle shield. This was the first planetary mission to use a cooled Ge detector. It was expected that the long duration in space of three years would cause an increase in the energy resolution of the detector due to radiation damage and could affect the expected science return of the GRS. Shortly before arrival, on August 21, 1993, contact was lost with the spacecraft following the pressurization of the propellent tank for the orbital-insertion rocket motor. During much of the cruise to Mars, the GRS was actively collecting background data. The instrument provided over 1200h of data collection during periods of both quiescent sun and solar flares. From the charged particle interactions in the shield, the total number of cosmic ray hits on the detector could be determined. The average cosmic ray flux at the MO GRS was about 2.5cm-2s-1. The estimated fluence of charged particles during cruise was about 108 particles cm-2 with 31% of these occurring during a single solar proton event of approximately 10 days duration. During cruise, the detector energy resolution determined from a background gamma-ray at 1312keV degraded from 2.4keV full-width at half-maximum shortly after launch to 6.4keV 11 months later. This result agrees well with measurements from ground-based accelerator irradiations (at 1.5GeV) on a similar size detector.

  12. BVRIJHK photometry and proper motion analysis of NGC 6253 and the surrounding field

    NASA Astrophysics Data System (ADS)

    Montalto, M.; Piotto, G.; Desidera, S.; Platais, I.; Carraro, G.; Momany, Y.; de Marchi, F.; Recio-Blanco, A.

    2009-10-01

    Context: We present a photometric and astrometric catalog of 187 963 stars located in the field around the old super-metal-rich Galactic open cluster NGC 6253. The total field-of-view covered by the catalog is 34”×33”. In this field, we provide CCD BVRI photometry. For a smaller region close to the cluster's center, we also provide near-infrared JHK photometry. Aims: We analyze the properties of NGC 6253 by using our new photometric data and astrometric membership. Methods: In June 2004, we targeted the cluster during a 10 day multi-site campaign, which involved the MPG/ESO 2.2 m telescope with its wide-field imager and the Anglo-Australian 3.9 m telescope, equipped with the IRIS2 near-infrared imager. Archival CCD images of NGC 6253 were used to derive relative proper motions and to calculate the cluster membership probabilities. Results: We have refined the cluster's fundamental parameters, deriving (V_0-M_v)=11.15, E(B - V) = 0.15, E(V - I) = 0.25, E(V - J) = 0.50, and E(V - H) = 0.55. The color excess ratios obtained using both the optical and near infrared colors indicate a normal reddening law in the direction of NGC 6253. The age of NGC 6253 at 3.5 Gyr, determined from our best-fitting isochrone appears to be slightly older than the previous estimates. Finally, we estimated the binary fraction among the cluster members to be ~20%-30% and identified 11 blue straggler candidates. Based on observation made at the European Southern Observatory, La Silla, Chile and at the Anglo-Australian Observatory, Siding Spring, Australia. The catalog presented in this paper is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/505/1129

  13. SU-E-T-364: 6X FFF and 10X FFF Portal Dosimetry Output Factor Verification: Application for SRS/SBRT

    SciTech Connect

    Gulam, M; Bellon, M; Gopal, A; Wen, N; Chetty, I; Gordon, J; Hames, S; Schmidt, M

    2014-06-01

    Purpose: To enhance portal dosimetry of high dose rate SRS/SBRT plan verifications with extensive imager measurement of output factors (OF). Methods: Electronic portal image dosimetry (EPID), implemented on the Varian Edge allows for acquisition of its two energies: 6X FFF and 10 FFF (1400 and 2400 MU/min, respectively) at source to imager distance (SID) =100cm without imager saturation. Square and rectangular aSi OF following EPID calibration were obtained. Data taken was similar to that obtained during beam commissioning (of almost all field sizes from 1×1 to 15×15 and 20×20 cm{sup 2}, [Trilogy] and [Edge], respectively) to construct a table using the OF tool for use in the Portal Dosimetry Prediction Algorithm (PDIP v11). The Trilogy 6x SRS 1000 MU/min EPID data were taken at 140 SID. The large number of OF were obtained for comparison to that obtained with diode detectors and ion chambers (cc13 for >3×3 field size). As Edge PDIP verification is currently ongoing, EPID measurements of three SRS/SBRT plans for the Trilogy were taken and compared to results obtained prior to these measurements. Results: The relative difference output factors of field sizes 2×2 and higher compared to commissioning data were (mean+/-SD, [range]): Edge 6X (−1.9+/−2.9%, [−5.9%,3.1%]), Edge 10X (−0.7+/−1.2%, [− 3.3%,0.8%] and Trilogy (0.03+/−0.5%, [−1.4%,1.1%]) with EPID over predicting. The results for the 140 SID showed excellent agreement throughout except at the 1×1 to 1×15 and 15×1 field sizes where differences were: −10.6%, −6.0% and −5.8%. The differences were also most pronounced for the 1×1 at 100 SID. They were −7.4% and −11.5% for 6X and 10X, respectively. The Gamma (3%, 1mm) for three clinical plans improved by 8.7+/−1.8%. Conclusion: Results indicate that imager output factor measurements at any SID of high dose rate SRS/SBRT are quite reliable for portal dosimetry plan verification except for the smallest fields. This work was not

  14. Sensory transduction at the frog semicircular canal: how hair cell membrane potential controls junctional transmission

    PubMed Central

    Martini, Marta; Canella, Rita; Rubbini, Gemma; Fesce, Riccardo; Rossi, Maria Lisa

    2015-01-01

    At the frog semicircular canals, the afferent fibers display high spontaneous activity (mEPSPs), due to transmitter release from hair cells. mEPSP and spike frequencies are modulated by stimulation that activates the hair cell receptor conductance. The relation between receptor current and transmitter release cannot be studied at the intact semicircular canal. To circumvent the problem, we combined patch-clamp recordings at the isolated hair cell and electrophysiological recordings at the cytoneural junction in the intact preparation. At isolated hair cells, the K channel blocker tetraethylammonium (TEA) is shown to block a fraction of total voltage-dependent K-conductance (IKD) that depends on TEA concentration but not on membrane potential (Vm). Considering the bioelectric properties of the hair cell, as previously characterized by this lab, a fixed fractional block of IKD is shown to induce a relatively fixed shift in Vm, provided it lies in the range −30 to −10 mV. The same concentrations of TEA were applied to the intact labyrinth while recording from single afferent fibers of the posterior canal, at rest and during mechanical stimulation. At the peak of stimulation, TEA produced increases in mEPSP rate that were linearly related to the shifts produced by the same TEA concentrations (0.1–3 mM) in hair cell Vm (0.7–5 mV), with a slope of 29.8 Hz/mV. The membrane potential of the hair cell is not linearly related to receptor conductance, so that the slope of quantal release vs. receptor conductance depends on the prevailing Vm (19.8 Hz/nS at −20 mV; 11 Hz/nS at −10 mV). Changes in mEPSP peak size were negligible at rest as well as during stimulation. Since ample spatial summation of mEPSPs occurs at the afferent terminal and threshold-governed spike firing is intrinsically nonlinear, the observed increases in mEPSP frequency, though not very large, may suffice to trigger afferent spike discharge. PMID:26157360

  15. Cigarette smoking and rate of gastric emptying: effect on alcohol absorption.

    PubMed Central

    Johnson, R D; Horowitz, M; Maddox, A F; Wishart, J M; Shearman, D J

    1991-01-01

    OBJECTIVE--To examine the effects of cigarette smoking on alcohol absorption and gastric emptying. DESIGN--Randomised crossover study. SETTING--Research project in departments of medicine and nuclear medicine. SUBJECTS--Eight healthy volunteers aged 19-43 who regularly smoked 20-35 cigarettes a day and drank small amounts of alcohol on social occasions. INTERVENTIONS--Subjects drank 400 ml of a radiolabelled nutrient test meal containing alcohol (0.5 g/kg), then had their rates of gastric emptying measured. Test were carried out (a) with the subjects smoking four cigarettes an hour and (b) with the subjects not smoking, having abstained for seven days or more. The order of the tests was randomised and the tests were conducted two weeks apart. MAIN OUTCOME MEASURES--Peak blood alcohol concentrations, absorption of alcohol at 30 minutes, amount of test meal emptied from the stomach at 30 minutes, and times taken for 50% of the meal to leave the proximal stomach and total stomach. RESULTS--Smoking was associated with reductions in (a) peak blood alcohol concentrations (median values in non-smoking versus smoking periods 13.5 (range 8.7-22.6) mmol/l v 11.1 (4.3-13.5) mmol/l), (b) area under the blood alcohol concentration-time curve at 30 minutes (264 x 10(3) (0-509 x 10(3)) mmol/l/min v 140 x 10(3)) (0-217 x 10(3) mmol/l/min), and (c) amount of test meal emptied from the stomach at 30 minutes (39% (5-86%) v 23% (0-35%)). In addition, smoking slowed both the 50% gastric emptying time (37 (9-83) minutes v 56 (40-280) minutes) and the intragastric distribution of the meal. There was a close correlation between the amount of test meal emptied from the stomach at 30 minutes and the area under the blood alcohol concentration-time curve at 30 minutes (r = 0.91; p less than 0.0001). CONCLUSION--Cigarette smoking slows gastric emptying and as a consequence delays alcohol absorption. PMID:1991182

  16. Living With A Red Dwarf: Rotation, Starspots, Activity Cycles, Coronal X-ray Activity And X-uv Irradiances Of Proxima Centauri

    NASA Astrophysics Data System (ADS)

    Jason, Merritt; Guinan, E.; Engle, S.; Pojmanski, G.

    2007-12-01

    As part of our Living with a Red Dwarf Program, we have carried out a detailed study of the radiative and plasma properties of the nearby dM5.5e star Proxima Centauri. Proxima Cen is noteworthy as the nearest star to the Sun. Because of its proximity ( 4.3 L.Y.) and membership in the α Cen system, Proxima Cen is an important star to use as a surrogate for solar-aged mid-dM stars. It is relatively bright (V = 11-mag) and has well determined observational and physical properties (MV, Teff, [Fe/H], angular diameter, mass and age). Importantly for our purposes, Proxima Cen has a reliable age of 5.5-6.0 Gyr from its association with the α Cen system in which α Cen A (G2 V) has a reliable isochronal age determination. We have analyzed 5 years of ASAS-3, V-band photometry to search for evidence of short- and long-term variations in brightness that could arise from magnetically related phenomenon (star spots, faculae, and possible UV flares). We also examine its coronal X-ray emission and variations as well as the stars chromospheric and transition regions in the UV from IUE and FUSE observations. The X-UV/optical data are combined and irradiances are calculated for use in extrasolar planet studies. From the photometry we find a rotational modulation of Prot = 83.5 days, in excellent agreement with the earlier HST/FGS study of Benedict et al. (1998). The character of its light variations indicates possible differential rotation as well as a probable long-term activity cycle of 6.9 +/- 0.5 yrs. Although Proxima Cen should be a fully convective star with a different magnetic dynamo (α2) than our Sun (αΩ), its overall magnetic behavior appears to be solar-like. This research is supported by grants from NSF/RUI AST-507536 and NASA Grants NNX06AD386 and NNG04G038G. We are grateful for this support.

  17. Biophysics and Molecular Biology of Cardiac Ion Channels for the Safety Pharmacologist.

    PubMed

    Pugsley, Michael K; Curtis, Michael J; Hayes, Eric S

    2015-01-01

    Cardiac safety pharmacology is a continuously evolving discipline that uses the basic principles of pharmacology in a regulatory-driven process to generate data to inform risk/benefit assessment of a new chemical entity (NCE). The aim of cardiac safety pharmacology is to characterise the pharmacodynamic/pharmacokinetic (PK/PD) relationship of a drug's adverse effects on the heart using continuously evolving methodology. Unlike Toxicology, safety pharmacology includes within its remit a regulatory requirement to predict the risk of rare cardiotoxic (potentially lethal) events such as torsades de pointes (TdP), which is statistically associated with drug-induced changes in the QT interval of the ECG due to blockade of I Kr or K v11.1 current encoded by hERG. This gives safety pharmacology its unique character. The key issues for the safety pharmacology assessment of a drug on the heart are detection of an adverse effect liability, projection of the data into safety margin calculation and clinical safety monitoring. This chapter will briefly review the current cardiac safety pharmacology paradigm outlined in the ICH S7A and ICH S7B guidance documents and the non-clinical models and methods used in the evaluation of new chemical entities in order to define the integrated risk assessment for submission to regulatory authorities. An overview of how the present cardiac paradigm was developed will be discussed, explaining how it was based upon marketing authorisation withdrawal of many non-cardiovascular compounds due to unanticipated proarrhythmic effects. The role of related biomarkers (of cardiac repolarisation, e.g. prolongation of the QT interval of the ECG) will be considered. We will also provide an overview of the 'non-hERG-centric' concepts utilised in the evolving comprehensive in vitro proarrhythmia assay (CIPA) that details conduct of the proposed ion channel battery test, use of human stem cells and application of in silico models to early cardiac safety

  18. Influence of seat foam and geometrical properties on BioRID P3 kinematic response to rear impacts.

    PubMed

    Szabo, T J; Voss, D P; Welcher, J B

    2003-12-01

    As the primary interface with the human body during rear impact, the automotive seat holds great promise for mitigation of Whiplash Associated Disorders (WAD). Recent research has chronicled the potential influence of both seat geometrical and constitutive properties on occupant dynamics and injury potential. Geometrical elements such as reduced head to head restraint, rearward offset, and increased head restraint height have shown strong correlation with reductions in occupant kinematics. The stiffness and energy absorption of both the seating foam and the seat infrastructure are also influential on occupant motion; however, the trends in injury mitigation are not as clear as for the geometrical properties. It is of interest to determine whether, for a given seat frame and infrastructure, the properties of the seating foam alone can be tailored to mitigate WAD potential. Rear impact testing was conducted using three model year 2000 automotive seats (Chevrolet Camaro, Chevrolet S-10 pickup, and Pontiac Grand Prix), using the BioRID P3 anthropometric rear impact dummy. Each seat was distinct in construction and geometry. Each seat back was tested with various foams (i.e., standard, viscoelastic, low or high density). Seat geometries and infrastructures were constant so that the influence of the seating foams on occupant dynamics could be isolated. Three tests were conducted on each foam combination for a given seat (total of 102 tests), with a nominal impact severity of Delta V = 11 km/h (nominal duration of 100 msec). The seats were compared across a host of occupant kinematic variables most likely to be associated with WAD causation. No significant differences (p < 0.05) were found between seat back foams for tests within any given seat. However, seat comparisons yielded several significant differences (p < 0.05). The Camaro seat was found to result in several significantly different occupant kinematic variables when compared to the other seats. No significant

  19. Clofarabine Plus Cytarabine Compared With Cytarabine Alone in Older Patients With Relapsed or Refractory Acute Myelogenous Leukemia: Results From the CLASSIC I Trial

    PubMed Central

    Faderl, Stefan; Wetzler, Meir; Rizzieri, David; Schiller, Gary; Jagasia, Madan; Stuart, Robert; Ganguly, Siddhartha; Avigan, David; Craig, Michael; Collins, Robert; Maris, Michael; Kovacsovics, Tibor; Goldberg, Stuart; Seiter, Karen; Hari, Parameswaran; Greiner, Jochen; Vey, Norbert; Recher, Christian; Ravandi, Farhad; Wang, Eunice S.; Vasconcelles, Michael; Huebner, Dirk; Kantarjian, Hagop M.

    2012-01-01

    Purpose To compare the receipt of clofarabine plus cytarabine (Clo+Ara-C arm) with cytarabine (Ara-C arm) in patients ≥ 55 years old with refractory or relapsed acute myelogenous leukemia (AML). Patients and Methods Patients were randomly assigned to receive either clofarabine (Clo) 40 mg/m2 or a placebo followed by Ara-C 1 g/m2 for five consecutive days. The primary end point was overall survival (OS). Secondary end points included event-free survival (EFS), 4-month EFS, overall remission rate (ORR; complete remission [CR] plus CR with incomplete peripheral blood count recovery), disease-free survival (DFS), duration of remission (DOR), and safety. Results Among 320 patients with confirmed AML (median age, 67 years), the median OS was 6.6 months in the Clo+Ara-C arm and 6.3 months in the Ara-C arm (hazard ratio [HR], 1.00; 95% CI, 0.78 to 1.28; P = 1.00). The ORR was 46.9% in the Clo+Ara-C arm (35.2% CR) versus 22.9% in the Ara-C arm (17.8% CR; P < .01). EFS (HR: 0.63; 95% CI, 0.49 to 0.80; P < .01) and 4-month EFS (37.7% v 16.6%; P < .01) favored the Clo+Ara-C arm compared with Ara-C arm, respectively. DFS and DOR were similar in both arms. Overall 30-day mortality was 16% and 5% for CLO+Ara-C and Ara-C arms, respectively. In the Clo+Ara-C and Ara-C arms, the most common grade 3 to 4 toxicities were febrile neutropenia (47% v 35%, respectively), hypokalemia (18% v 11%, respectively), thrombocytopenia (16% v 17%, respectively), pneumonia (14% v 10%, respectively), anemia (13% v 0%, respectively), neutropenia (11% v 9%, respectively), increased AST (11% v 2%, respectively), and increased ALT (10% v 3%, respectively). Conclusion Although the primary end point of OS did not differ between arms, Clo+Ara-C significantly improved response rates and EFS. Study follow-up continues, and the role of clofarabine in the treatment of adult patients with AML continues to be investigated. PMID:22585697

  20. Energy levels of {sup 251}Cf populated in the {alpha} decay of {sub 100}{sup 255}Fm and EC decay of {sub 99}{sup 251}Es

    SciTech Connect

    Ahmad, I.; Greene, J.P.; Moore, E.F.; Kondev, F.G.; Chasman, R.R.; Porter, C.E.; Felker, L.K.

    2005-11-01

    Gamma-ray singles spectra of extremely pure (chemically and isotopically) samples of {sup 255}Fm, with strengths of {approx}1 mCi, have been measured with a high-resolution 2-cm{sup 2}x10-mm germanium LEPS detector and with a 25% Ge spectrometer. Gamma rays with intensities as low as 1.0x10{sup -6}% per {sup 255}Fm {alpha} decay have been identified. The electron spectrum of a mass-separated {sup 251}Es source was measured with a cooled Si(Li) electron spectrometer. The spectrum provided the conversion coefficients of low-energy transitions in {sup 251}Cf and thereby their multipolarities. The present measurements confirm the previous assignments of single-particle states in {sup 251}Cf. These include 1/2{sup +}[620], 0.0 keV; 7/2{sup +}[613], 106.30 keV; 3/2{sup +}[622], 177.59 keV; 11/2{sup -}[725], 370.47 keV; 9/2{sup -}[734], 433.91 keV; 5/2{sup +}[622], 543.98 keV; 1/2{sup -}[750], 632.0 keV; 9/2{sup +}[615], 683 keV; and 9/2{sup +}[604], 974.0 keV. A vibrational band was identified in previous studies at 981.4 keV and given an assignment of {l_brace}7/2{sup +}[613]x2{sup -}{r_brace}3/2{sup -}. Three new vibrational bands are identified in the present work at 942.5, 1086.5, and 1250.0 keV with tentative assignments {l_brace}7/2{sup +}[613]x1{sup -}{r_brace}5/2{sup -},{l_brace}7/2{sup +}[613]x1{sup -}{r_brace}9/2{sup -}, and {l_brace}7/2{sup +}[613]x0{sup +}{r_brace}7/2{sup +}, respectively. A level was identified at 1185.5 keV with spin of 5/2 or 7/2 but it was not given any configuration assignment. Another level was identified at 1077.5 keV and given a spin of 9/2. Again, no configuration could be assigned to this level.

  1. Chloramphenicol versus ampicillin plus gentamicin for community acquired very severe pneumonia among children aged 2-59 months in low resource settings: multicentre randomised controlled trial (SPEAR study)

    PubMed Central

    2008-01-01

    Objective To evaluate whether five days’ treatment with injectable ampicillin plus gentamicin compared with chloramphenicol reduces treatment failure in children aged 2-59 months with community acquired very severe pneumonia in low resource settings. Design Open label randomised controlled trial. Setting Inpatient wards within tertiary care hospitals in Bangladesh, Ecuador, India, Mexico, Pakistan, Yemen, and Zambia. Participants Children aged 2-59 months with WHO defined very severe pneumonia. Intervention Chloramphenicol versus a combination of ampicillin plus gentamicin. Main outcome measures Primary outcome measure was treatment failure at five days. Secondary outcomes were treatment failure defined similarly among all participants evaluated at 48 hours and at 10 and 21 days. Results More children failed treatment with chloramphenicol at day 5 (16% v 11%; relative risk 1.43, 95% confidence interval 1.03 to 1.97) and also by days 10 and 21. Overall, 112 bacterial isolates were obtained from blood and lung aspirates in 110 children (11.5%), with the most common organisms being Staphylococcus aureus (n=47) and Streptococcus pneumoniae (n=22). In subgroup analysis, bacteraemia with any organism increased the risk of treatment failure at 21 days in the chloramphenicol group (2.09, 1.41 to 3.10) but not in the ampicillin plus gentamicin group (1.12, 0.59 to 2.13). Similarly, isolation of S pneumoniae increased the risk of treatment failure at day 21 (4.06, 2.73 to 6.03) and death (5.80, 2.62 to 12.85) in the chloramphenicol group but not in the ampicillin plus gentamicin group. No difference was found in treatment failure for children with S aureus bacteraemia in the two groups, but the power to detect a difference in this subgroup analysis was low. Independent predictors of treatment failure by multivariate analysis were hypoxaemia (oxygen saturation <90%), receiving chloramphenicol, being female, and poor immunisation status. Conclusion Injectable ampicillin plus

  2. CHANDRA OBSERVATIONS OF THE OLD PULSAR PSR B1451-68

    SciTech Connect

    Posselt, B.; Pavlov, G. G.; Garmire, G. P.; Manchester, R. N.; Kargaltsev, O. E-mail: pavlov@astro.psu.edu

    2012-04-20

    We present 35 ks Chandra ACIS observations of the 42 Myr old radio pulsar PSR B1451-68. A point source is detected 0.''32 {+-} 0.''73 from the expected radio pulsar position. It has {approx}200 counts in the 0.3-8 keV energy range. We identify this point source as the X-ray counterpart of the radio pulsar. PSR B1451-68 is located close to a Two Micron All Sky Survey point source for which we derive 7% as the upper limit on the flux contribution to the measured pulsar X-ray flux. The pulsar spectrum can be described by either a power-law model with photon index {Gamma} = 2.4{sup +0.4}{sub -0.3} and a unrealistically high absorbing column density N{sub H} = (2.5{sup +1.2}{sub -1.3}) Multiplication-Sign 10{sup 21} cm{sup -2}, or by a combination of a kT = 0.35{sup +0.12}{sub -0.07} keV blackbody and a {Gamma} = 1.4 {+-} 0.5 power-law component for N{sup DM}{sub H} = 2.6 Multiplication-Sign 10{sup 20} cm{sup -2}, estimated from the pulsar dispersion measure. At the parallactic, a Lutz-Kelker bias corrected distance of 480 pc, the non-thermal X-ray luminosities in the 0.3-8 keV energy band are either L{sup nonth}{sub 0.3-8keV} = (11.3 {+-} 1.7) Multiplication-Sign 10{sup 29} erg s{sup -1} or L{sup nonth}{sub 0.3-8keV} = (5.9{sup +4.9}{sub -5.0}) Multiplication-Sign 10{sup 29} erg s{sup -1}, respectively. This corresponds to non-thermal X-ray efficiencies of either {eta}{sub 0.3-8keV}{sup north}=L{sub 0.3-8keV}{sup north}/E-dot{approx}5x10{sup -3} or 3 Multiplication-Sign 10{sup -3}, respectively.

  3. A Normal Supermassive Black Hole in NGC 1277

    NASA Astrophysics Data System (ADS)

    Graham, Alister W.; Durré, Mark; Savorgnan, Giulia A. D.; Medling, Anne M.; Batcheldor, Dan; Scott, Nicholas; Watson, Beverly; Marconi, Alessandro

    2016-03-01

    The identification of galaxies with “overly massive” black holes requires two measurements: a black hole mass (Mbh) and a host spheroid mass ({M}{{sph,\\ast }}). Here we provide our measurements for NGC 1277. Our structural decomposition reveals that NGC 1277 is dominated by a “classical” spheroid with a Sérsic index n = 5.3, a half-light radius {R}{{e,major}}=2.1 {{kpc}}, and a stellar mass of 2.7× {10}11\\quad {M}⊙ (using {M}*/{L}V=11.65, Martín-Navarro et al.). This mass is an order of magnitude greater than originally reported. Using the latest Mbh-n, Mbh-{M}{{sph,\\ast }}, and Mbh-σ relations, the expected black hole mass is, respectively, ({0.57}-0.40+1.29)× {10}9\\quad {M}⊙ , ({1.58}-1.13+4.04)× {10}9\\quad {M}⊙ , and ({2.27}-1.44+4.04)× {10}9\\quad {M}⊙ (using σ = 300 km s-1) for which the “sphere-of-influence” is 0.″31. Our new kinematical maps obtained from laser guide star assisted, adaptive optics on the Keck I Telescope dramatically reaffirm the presence of the inner, nearly edge-on, disk seen in the galaxy image. We also report that this produces a large velocity shear (˜400 km s-1) across the inner 0.″2 (70 pc) plus elevated values of \\sqrt{{σ }2+{V}2} across the inner (+/- 3\\buildrel{\\prime\\prime}\\over{.} 8)× (+/- 0\\buildrel{\\prime\\prime}\\over{.} 6) region of the galaxy. Our new multi-Gaussian expansion (MGE) models and Jeans Anisotropic MGE analysis struggled to match this extended component. Our optimal black hole mass, albeit a probable upper limit because of the disk is 1.2 × 109 M⊙ (M/{L}V=12.3). This is an order of magnitude smaller than originally reported and 4 times smaller than recently reported. It gives an {M}{{bh}}/{M}{{sph,\\ast }} ratio of 0.45% in agreement with the median (≈0.5%) and range (0.1%-5.0%) observed in non-dwarf, early-type galaxies. This result highlights the need for caution with inner disks.

  4. Strongly bound metastable states of B2 + 2

    NASA Astrophysics Data System (ADS)

    Bruna, Pablo J.; Wright, James S.

    1990-08-01

    The stabilities of about 25 electronic states of B2+2 have been investigated using a multireference CI (MRD-CI) method and an AO basis set composed of 6s4p2d contracted Gaussian species per atom, including semidiffuse functions relevant for an adequate description of charge transfer interactions. The ground state X1∑+g (σ2gσ2u) is repulsive, as expected by its electronic configuration with a zero bond order. In spite of this and the doubly-positive charge, many excited states are found to be metastable, four of them (11∏g, 11∏u, 13∑-g, and 11Δg ) having potential wells from 1.52 eV (11∏u) to 2.83 eV (13∑-g). Relative to the ground state configuration, the metastable states arise from the excitations σu→σg(3∑+u), σu→πu(3,1∏g), σ2u→σgπu(3,1∏u), and σ2u→π2u(3∑-g, 1Δg, 1∑+g); they are analogous to those states showing deep local minima in B2 and B+2. Differences in stabilities among quasibound states can be explained on the basis of the asymptotic ΔE's between repulsive channels B++B+ and appropriate higher-lying limits (states) B+B2+ of bonding character; another important factor governing stability is the actual bonding character of the electronic configurations assigned to each state. The vertical double-ionization potential B2→B2+2(π2u→∞) between both ground states is 27.97 eV, the repulsive X1∑+g dication state being created with 8.37 eV excess energy relative to B++B+. Doubly-ionized states with a chance of being detected because of their long lifetimes against predissociation are those showing a strongly quasibound character, such as (with the vertical double ionization potential in eV given in parentheses): 11∏g(σuπu→∞; 30.29); 11∏u(σ2uπu→σg∞; 31.30); 13∑-g(σ2u→∞; 31.33), and 11Δg(σ2u→∞; 31.95).

  5. SU-E-T-358: Monte Carlo Dose Calculation of Small Field Electron Beams

    SciTech Connect

    Wu, Q; Rodrigues, A; Yin, F; Sawkey, D

    2014-06-01

    Purpose: Dynamic radiotherapy involving electron beams such as Dynamic Electron Arc Radiotherapy (DEAR) requires accurate dose modelling of small field sizes, similar to the requirement of IMRT field on the small photon field. The current commercial electron Monte Carlo algorithms such as eMC v11 in Eclipse were developed for standard field sizes and do not support the planning of dynamic therapy yet. The purpose of this study is to develop a method to accurately model small field electron beam dosimetry using Monte Carlo simulations. Methods: Comparison between eMC, phantom measurements (diode), and Monte Carlo (MC) simulations (BEAMnrc/DOSYZnrc) were performed for a Varian TrueBeam linac. MC simulations utilized Varian TrueBeam phase space files which had been validated in another study. Static single small field was assessed by comparing dose distributions in water for a 16 MeV beam for circular (2 cm diameter) and rectangular (1×10 cm{sup 2}) cut-out. MC was performed with a resolution of 2.5×2.5×2 mm{sup 2} and statistical uncertainty < 4%. The dose distribution was averaged over adjacent bins to improve precision. Depth dose and orthogonal profiles were evaluated. Results: Small field PDDs differ from those with standard cones. For both circular and rectangular cutouts, the difference in range R8 0-R1 0 is less than 2 mm and in dose within 2%. For the orthogonal profiles, field size and penumbra differences were within 1 mm at depth of maximum dose. The eMC displayed a distinctive “step” in the out-field dose profile in disagreement with both measurement and MC results and needs further investigation. Conclusion: MC was able to characterize the small field dosimetry with good agreement with the measurement data, and thus offers the opportunity for treatment planning of dynamic radiotherapy. Analyses for all other electron energies and cut-out sizes are under way and results will be included in the presentation.

  6. Metabolism of glycerophospholipid, bile acid and retinol is correlated with the early outcomes of autoimmune hepatitis.

    PubMed

    Zhou, Chao; Jia, Hong-Mei; Liu, Yue-Tao; Yu, Meng; Chang, Xing; Ba, Yuan-Ming; Zou, Zhong-Mei

    2016-04-26

    Autoimmune hepatitis (AIH) is a complex liver disease with an increasing prevalence in recent years and can develop into the severe or fulminant form if the patients are not diagnosed accurately or treated in time. However, AIH accurate diagnosis, especially at the early stage, is still difficult to perform due to the absence of specific diagnostic markers and the large heterogeneity of its clinical, laboratory and histological features. To evaluate the biochemical process of AIH at the early stage, we investigated serum metabolic alterations in mice with liver injury induced by concanavalin A (Con A), which closely mimics the immune and inflammatory response of AIH in humans. Metabonomic profiling was performed by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC Q-TOF MS). As a result, fourteen metabolites were detected as potential biomarkers related to the early stage of the liver injury, including two bile acids (taurocholic acid (V1) and taurochenodeoxycholic acid (V2)), three long-chain acylcarnitines (tetradecanoylcarnitine (V4), linoleyl carnitine (V8) and l-palmitoylcarnitine (V9)), seven glycerophospholipids (lysoPE (18 : 0/0 : 0) (V3), lysoPC (16 : 0) (V5), lysoPC (18 : 1) (V7), lysoPC (18 : 0) (V10), lysoPC (20 : 1) (V11), lysoPE (22 : 0/0 : 0) (V12) and lysoPC (20 : 0) (V13)), a bilirubin (V14), and a retinyl ester (V6). Moreover, partial least square regression analysis (RLS-RA) showed that metabolism of glycerophospholipids (P2), bile acids (P4) and retinol (P5) was highly correlated with the clinical outcomes, suggesting they played key roles in the early stage of the liver injury. Our results also demonstrated that a metabonomic approach coupled with PLS-RA is a powerful tool with which changes can be characterized in the levels of endogenous metabolites associated with disease progression and to assist in further understanding the molecular mechanism of the disease. PMID

  7. Self correction of refractive error among young people in rural China: results of cross sectional investigation

    PubMed Central

    Zhang, Mingzhi; Zhang, Riping; He, Mingguang; Liang, Wanling; Li, Xiaofeng; She, Lingbing; Yang, Yunli; MacKenzie, Graeme; Silver, Joshua D; Ellwein, Leon; Moore, Bruce

    2011-01-01

    Objective To compare outcomes between adjustable spectacles and conventional methods for refraction in young people. Design Cross sectional study. Setting Rural southern China. Participants 648 young people aged 12-18 (mean 14.9 (SD 0.98)), with uncorrected visual acuity ≤6/12 in either eye. Interventions All participants underwent self refraction without cycloplegia (paralysis of near focusing ability with topical eye drops), automated refraction without cycloplegia, and subjective refraction by an ophthalmologist with cycloplegia. Main outcome measures Uncorrected and corrected vision, improvement of vision (lines on a chart), and refractive error. Results Among the participants, 59% (384) were girls, 44% (288) wore spectacles, and 61% (393/648) had 2.00 dioptres or more of myopia in the right eye. All completed self refraction. The proportion with visual acuity ≥6/7.5 in the better eye was 5.2% (95% confidence interval 3.6% to 6.9%) for uncorrected vision, 30.2% (25.7% to 34.8%) for currently worn spectacles, 96.9% (95.5% to 98.3%) for self refraction, 98.4% (97.4% to 99.5%) for automated refraction, and 99.1% (98.3% to 99.9%) for subjective refraction (P=0.033 for self refraction v automated refraction, P=0.001 for self refraction v subjective refraction). Improvements over uncorrected vision in the better eye with self refraction and subjective refraction were within one line on the eye chart in 98% of participants. In logistic regression models, failure to achieve maximum recorded visual acuity of 6/7.5 in right eyes with self refraction was associated with greater absolute value of myopia/hyperopia (P<0.001), greater astigmatism (P=0.001), and not having previously worn spectacles (P=0.002), but not age or sex. Significant inaccuracies in power (≥1.00 dioptre) were less common in right eyes with self refraction than with automated refraction (5% v 11%, P<0.001). Conclusions Though visual acuity was slightly worse with self refraction than automated or

  8. Health response of two communities to military antennae in Cyprus

    PubMed Central

    Preece, A W; Georgiou, A G; Dunn, E J; Farrow, S C

    2007-01-01

    Objectives This study investigated concerns that have been raised about past and future health effects caused by high power transmissions of high frequency (7–30 MHz) radio waves from military antenna systems at Akrotiri, Cyprus. Methods A cross‐sectional study of three villages (two exposed, one unexposed) collected longitudinal and short‐term radiofrequency measurements. Health data were collected using questionnaires containing information on demographic factors, specific illnesses, general health (SF‐36 well‐being questionnaire), reproductive history, childhood illnesses, risk perception and mortality. Analysis was with SPSS v11.5 using cross tabulations of non‐parametric data and tests for significance. Key health outcomes were subjected to logistic regression analysis. Results Field strengths within the two “exposed” villages were a maximum of 0.30 (Volts/Vm−1 metre) from the 17.6 MHz military transmissions and up to 1.4 Vm−1 from unspecified sources, mainly cell phone frequencies. The corresponding readings in the control village were <0.01 Vm−1. Compared with the control village there were highly significant differences in the reporting of migraine (OR 2.7, p<0.001), headache (OR 3.7, p<0.001), and dizziness (OR 2.7, p<0.001). Residents of the exposed villages showed greater negative views of their health in all eight domains of the SF‐36. There were also higher levels of perceived risk, particularly to noise and electromagnetic “pollution”. All three villages reported higher values of risk perception than a UK population. There was no evidence of birth abnormalities or differences in gynaecological or obstetric history. Numbers of cancers were too small to show differences. Conclusion It was clear that even this close (1–3 km) to powerful transmissions, the dominant sources of radiofrequency fields were cell phone and national broadcast systems. There was no excess of cancer, birth defects or obstetric problems

  9. SU-E-T-551: PTV Is the Worst-Case of CTV in Photon Therapy

    SciTech Connect

    Harrington, D; Liu, W; Park, P; Mohan, R

    2014-06-01

    Purpose: To examine the supposition of the static dose cloud and adequacy of the planning target volume (PTV) dose distribution as the worst-case representation of clinical target volume (CTV) dose distribution for photon therapy in head and neck (H and N) plans. Methods: Five diverse H and N plans clinically delivered at our institution were selected. Isocenter for each plan was shifted positively and negatively in the three cardinal directions by a displacement equal to the PTV expansion on the CTV (3 mm) for a total of six shifted plans per original plan. The perturbed plan dose was recalculated in Eclipse (AAA v11.0.30) using the same, fixed fluence map as the original plan. The dose distributions for all plans were exported from the treatment planning system to determine the worst-case CTV dose distributions for each nominal plan. Two worst-case distributions, cold and hot, were defined by selecting the minimum or maximum dose per voxel from all the perturbed plans. The resulting dose volume histograms (DVH) were examined to evaluate the worst-case CTV and nominal PTV dose distributions. Results: Inspection demonstrates that the CTV DVH in the nominal dose distribution is indeed bounded by the CTV DVHs in the worst-case dose distributions. Furthermore, comparison of the D95% for the worst-case (cold) CTV and nominal PTV distributions by Pearson's chi-square test shows excellent agreement for all plans. Conclusion: The assumption that the nominal dose distribution for PTV represents the worst-case dose distribution for CTV appears valid for the five plans under examination. Although the worst-case dose distributions are unphysical since the dose per voxel is chosen independently, the cold worst-case distribution serves as a lower bound for the worst-case possible CTV coverage. Minor discrepancies between the nominal PTV dose distribution and worst-case CTV dose distribution are expected since the dose cloud is not strictly static. This research was supported by

  10. Fast sodium current in cardiac muscle. A quantitative description.

    PubMed Central

    Ebihara, L; Johnson, E A

    1980-01-01

    The voltage and time-dependence of the tetrodotoxin sensitive, fast sodium current in cardiac muscle is described with the Hodgkin-Huxley formalism using two microelectrode, voltage-clamp data obtained by Ebihara et al. (1980, J. Gen. Physiol., 75:437) from small spherical clusters of tissue-cultured 11-d-old embryonic heart cells. The data chosen from that study for quantitative analysis was obtained at 37 degrees C and in standard tissue-culture medium; it was not smoothed, and the capacitive transient was sufficiently brief to make its removal unnecessary. The sodium current, INa, is considered to be given by the following equation: INa = gNa m3h(V - VNa), where gNa is a constant (23 mS), VNa is the sodium equilibrium potential (29 mV), and m and h are independent, first order, dimensionless variables, which can vary between 0 and 1, as defined by the following differential equations, dm/dt = alpha m(1 - m) - beta mm and dh/dt = alpha h(1 - h) - beta hh, where the rate coefficients, alpha m = [0.32 x (V + 47.13)]/[1 - exp(V + 47.13)] and beta m = 0.08 x exp (-V/11). For potentials more positive than -40 mV, alpha h = 0 and beta h = 1/0.13 (exp [(V + 10.66)/ - 11.1] + 1), and for potentials more negative than -40 mV, alpha h = 0.135 x exp [(-80 - V)/6.8] and beta h = 3.56 x exp (0.079V) + 3.1 x 10(5) exp (0.35V). These functions of potential are similar to those of the squid at 15 degrees C, except that their magnitudes are larger (faster). Using these model equations the membrane current in a membrane patch with and without a series resistance was simulated. For the value of series resistance estimated for the preparation from which the analyzed data were obtained, the effects of series resistance on the shape and magnitude of the inward transient current were found to be minimal. It was concluded that their should be no large errors in the data, even in the absence of complete series resistance compensation. PMID:7260301

  11. Mid-IR and radio images of IC 418: dust in a young planetary nebula.

    NASA Astrophysics Data System (ADS)

    Meixner, M.; Skinner, C. J.; Keto, E.; Zijlstra, A.; Hoare, M. G.; Arens, J. F.; Jernigan, J. G.

    1996-09-01

    " radius. This structure may suggest a mass loss history for IC 418 in which its progenitor AGB star experienced a superwind (˙(M)~4x10^-5^Msun_/yr, v~11km/s) just before departing the AGB.

  12. Dose Measurements of Ultra-Shallow Implanted As and B in Si by RBS and ERD

    NASA Astrophysics Data System (ADS)

    Pelicon, P.; Ravi Prasad, G. V.; El Bouanani, M.; Guo, B. N.; Birt, D.; Duggan, J. L.; McDaniel, F. D.

    2003-08-01

    Continuous miniaturization of integrated circuits requires narrower dopant profile depth in the Si channel and consequently the use of ultra-shallow implants in the manufacturing process. Secondary Ion Mass Spectroscopy (SIMS) is routinely used to measure the boron depth concentration profiles. However, due to the altered nature of the near-surface sputtering process inherent to SIMS, it underestimates the B implanted doses for implantation energies below 2 keV. Alternate ion beam methods for absolute dose measurements of ultra-shallow implanted As and B in Si are presented in this study. The dopant implant energies ranged from 250 eV, to 5 keV for boron and from 500 eV to 5 keV for arsenic. Implanted doses for both B and As varied from 2 × 1013 to 1 × 1015 atoms/cm2. The arsenic implants were studied with Rutherford Backscattering Spectrometry (RBS) using 2 MeV carbon ions. The absolute arsenic implanted doses were measured to an accuracy of better than 5%. The 1 keV arsenic implants were extensively studied for radiation damage with a 12C beam. No appreciable arsenic dose loss was observed during C irradiation for an integrated charge of ⩽ 80 μC, which was the maximum used for these studies. For the B implants, Elastic Recoil Detection (ERD) was used with 14 MeV F4+ ions. A 9.4 μm Mylar foil was found to adequately stop the scattered 19F ions and give good energy separation for the 11B recoiled ions. The absolute dose measurements are ˜ 5% for the 5 keV 11B implants. Significant radiation damage was observed for the ultra shallow implants and the measured B dose has been obtained by extrapolation to the zero integrated charge of the beam. The absolute boron dose measurements of the ultra shallow (250 eV) implants were determined with an accuracy better than 10%.

  13. Ion permeation through single channels activated by acetylcholine in denervated toad sartorius skeletal muscle fibers: effects of alkali cations.

    PubMed

    Quartararo, N; Barry, P H; Gage, P W

    1987-01-01

    The gigaohm seal technique was used to study ion permeation through acetylcholine-activated channels in cell-attached patches of the extrajunctional membrane of chronically denervated, enzyme-treated cells from the sartorius muscle of the toad Bufo marinus. The most frequently occurring channel type (greater than 95% of channel openings), provisionally classified as 'extrajunctional,' had a chord conductance of approximately 25 pS under normal conditions (-70 mV, 11 degrees C, Normal Toad Ringer's). The less frequently observed channel type (less than 5% of channel openings), classified as a 'junctional' type, had a conductance of 35 pS under the same conditions, and a similar null potential. In many patches, a small percentage (usually less than 2%) of openings of the extrajunctional channel displayed a lower conductance state. The shape of the I-V curves obtained for the extrajunctional channel depended on the predominant extracellular cation. For Cs and K, the I-V curves were essentially linear over the voltage range +50 to -150 mV across the patch, suggesting that the potential independent component of the energy profile within the channel was symmetrical. For Li, the I-V curve was very nonlinear, displaying a significant sublinearity at hyperpolarized potentials. Both an electrodiffusion and a symmetrical uniform four-barrier, three-site rate-theory model provided reasonable fits to the data, whereas symmetrical two-barrier, single-site rate-theory models did not. For the alkali cations examined, the relative permeability sequence was PCs greater than PK greater than PNa greater than PLi--a "proportional" selectivity sequence. This was different from the single channel conductance sequence which was found to be gamma K greater than gamma Cs greater than gamma Na greater than gamma Li implying that ions do not move independently through the channel. The relative binding constant sequence for the channel sites was found to be a "polarizability" sequence, i

  14. New calibration standard for LA-ICPMS analysis of sulphides

    NASA Astrophysics Data System (ADS)

    Belousov, I.; Danyushevsky, L. V.; Olin, P. H.; Gilbert, S.; Thompson, J. M.

    2014-12-01

    Currently available calibration standards for LA-ICPMS analysis for a wide range of trace elements in sulphide minerals include hydrothermally-precipitated Fe-Cu-Zn-S powder doped with trace metals MASS-1 [1] and Li borate glass STDGL-2 [2]. Both of them are not ideal due to a limited range of elements they contain and/or non-homogenous distribution and low concentrations of elements. MASS-1 suffers from a limited range of elements and poor homogeneity, whereas STDGL-2 has low and/or unevenly distributed volatile elements and precious metals (e.g. Se, Te, Tl, Pt, Au). In order to produce a better calibration standard, we have experimented with fusing sulphide mineral mixes in a variety of borate-based fluxes. A range of flux compositions, heating and cooling regimes and times at high temperatures have been tested in order to produce a homogeneous glass disk with an appropriate proportion of sulphide, while retaining volatile elements. Best results were achieved with using Li tetraborate as a flux with Na nitrate as an oxidizing agent by fusing with an LPG fluxer (M4 by Claisse). Selenium, tellurium and tin were added in the elemental form, whereas thallium was added as carbonate (Tl2CO3). A range of elements was added to provide capability for detecting known common interferences on chalcophile and siderophile elements (e.g. Gd, Hf, Ta, W, Zr, Sr). New standard glass STDGL-3 contains homogeneously distributed volatile elements (Se, Te, Tl, Sn) and precious metals (Au, Pt). A larger proportion of volatile elements was retained (100% Ge, 80% Re, 70% Te, 60% Sn, 20% Tl, 20% Se). Most problematic elements turned out to be Se and Tl, which volatilize together through a network of narrow zones, and Pt and Au, which form micro inclusions. Suitability of the new standard for LA-ICPMS analysis of sulphide minerals for trace element concentrations and Pb isotopes will be demonstrated. [1] Wilson et al., 2002. JAAS, v.17, pp.406-409[2] Danyushevsky et al., 2011. GEEA,. v.11

  15. Determinants of pharmaceutical expenditures of urban households: A time series study in Kermanshah province (Iran)

    PubMed Central

    Matin, Behzad Karami; Azami, Saeed Reza; Mahmoudi, Saeid; Rezaei, Satar; Shaahmadi, Faramarz; Karyani, Ali Kazemi

    2015-01-01

    Introduction In recent decades, the development of medical and pharmaceutical science has led to a heavy financial burden on the government, insurance companies, and the general population. Due to the increasing the cost of pharmaceutical products in the Kermanshah Province, policy makers have tried to identify the factors that resulted in the increases. The aim of this study was to determine the main factors that affect the expenditures for pharmaceutical products by urban households in Kermanshah Province, Iran. Methods This analytical-descriptive study was conducted using time series method. The study population was urban households of Kermanshah Province from 1991 to 2013. The explanatory variables of the log-log model were drug price index (LnDPI), the average income of urban households (LnINC), the number of physicians per 1,000 people (LnPH), and the number of hospital beds per 1,000 people (LnBE).The required data were acquired from the Statistical Center of the Ministry of Health and Medical Education. The unit root was evaluated by the Dickey-Fuller test. Stata v.11 software was used for the statistical analysis. Results Coefficients of LnDPI and LnPH were 0.97 and 0.77, respectively, and they were statistically significant (p < 0.05). Also, the coefficients of D. LnINC (first difference of LnINC) and LnBE were 0.34 and 1.8, respectively, and both of them were statistically insignificant (p > 0.05). Conclusion The results showed that drugs are non-elastic and essential for households. It should be noted that the health policy makers in Iran should conduct appropriate planning to ensure both the physical and financial accessibility to drugs by urban households. The development of basic and supplementary health insurance coverage, especially for poor populations and urban areas where there are patients with chronic diseases, can be a suitable solution to reduce barriers to acquiring the required drugs. PMID:26767100

  16. HAT-P-20b-HAT-P-23b: FOUR MASSIVE TRANSITING EXTRASOLAR PLANETS

    SciTech Connect

    Bakos, G. A.; Hartman, J.; Torres, G.; Latham, D. W.; Noyes, R. W.; Kipping, D.; Esquerdo, G. A.; Beky, B.; Perumpilly, G.; Everett, M.; Sasselov, D. D.; Stefanik, R. P.; Kovacs, Geza; Fischer, D. A.; Johnson, J. A.; Marcy, G. W.; Howard, A. W.; Shporer, A.; Buchhave, L. A.; Lazar, J.; and others

    2011-12-01

    We report the discovery of four relatively massive (2-7 M{sub J}) transiting extrasolar planets. HAT-P-20b orbits the moderately bright V = 11.339 K3 dwarf star GSC 1910-00239 on a circular orbit, with a period P = 2.875317 {+-} 0.000004 days, transit epoch T{sub c} = 2455080.92661 {+-} 0.00021 (BJD{sub UTC}), and transit duration 0.0770 {+-} 0.0008 days. The host star has a mass of 0.76 {+-} 0.03 M{sub Sun }, radius of 0.69 {+-} 0.02 R{sub Sun }, effective temperature 4595 {+-} 80 K, and metallicity [Fe/H] = +0.35 {+-} 0.08. The planetary companion has a mass of 7.246 {+-} 0.187 M{sub J} and a radius of 0.867 {+-} 0.033 R{sub J} yielding a mean density of 13.78 {+-} 1.50 g cm{sup -3}. HAT-P-21b orbits the V = 11.685 G3 dwarf star GSC 3013-01229 on an eccentric (e = 0.228 {+-} 0.016) orbit, with a period P = 4.124481 {+-} 0.000007 days, transit epoch T{sub c} = 2454996.41312 {+-} 0.00069, and transit duration 0.1530 {+-} 0.0027 days. The host star has a mass of 0.95 {+-} 0.04 M{sub Sun }, radius of 1.10 {+-} 0.08 R{sub Sun }, effective temperature 5588 {+-} 80 K, and metallicity [Fe/H] = +0.01 {+-} 0.08. The planetary companion has a mass of 4.063 {+-} 0.161 M{sub J} and a radius of 1.024 {+-} 0.092 R{sub J} yielding a mean density of 4.68{sup +1.59}{sub -0.99} g cm{sup -3}. HAT-P-21b is a borderline object between the pM and pL class planets, and the transits occur near apastron. HAT-P-22b orbits the bright V = 9.732 G5 dwarf star HD 233731 on a circular orbit, with a period P = 3.212220 {+-} 0.000009 days, transit epoch T{sub c} = 2454930.22001 {+-} 0.00025, and transit duration 0.1196 {+-} 0.0014 days. The host star has a mass of 0.92 {+-} 0.03 M{sub Sun }, radius of 1.04 {+-} 0.04 R{sub Sun }, effective temperature 5302 {+-} 80 K, and metallicity [Fe/H] = +0.24 {+-} 0.08. The planet has a mass of 2.147 {+-} 0.061 M{sub J} and a compact radius of 1.080 {+-} 0.058 R{sub J} yielding a mean density of 2.11{sup +0.40}{sub -0.29} g cm{sup -3}. The host star also

  17. HUBBLE'S PANORAMIC PORTRAIT OF A VAST STAR-FORMING REGION

    NASA Technical Reports Server (NTRS)

    2002-01-01

    giant shell, devoid of gas and dust. Still later, all of the most massive stars and gas will have disappeared from the entire region. Only older, less massive stars will remain in a region cleared of gas and dust. The mosaic image of 30 Doradus consists of five overlapping pictures taken between January 1994 and September 2000 by Hubble's Wide Field and Planetary Camera 2. Several color filters were used to enhance important details in the stars and the nebula. Blue corresponds to the hot stars. The greenish color denotes hot gas energized by the central cluster of stars. Pink depicts the glowing edges of the gas and dust clouds facing the cluster, which are being bombarded by winds and radiation. Reddish-brown represents the cooler surfaces of the clouds, which are not receiving direct radiation from the central cluster. Credits: NASA, N. Walborn and J. Ma`iz-Apell`aniz (Space Telescope Science Institute, Baltimore, MD), R. Barb`a (La Plata Observatory, La Plata, Argentina)

  18. The TRAPPIST comet survey

    NASA Astrophysics Data System (ADS)

    Jehin, E.; Opitom, C.; Manfroid, J.; Hutsemékers, D.; Gillon, M.

    2014-07-01

    TRAPPIST (TRAnsiting Planets and PlanetesImals Small Telescope) is a 60-cm robotic telescope that has been installed in June 2010 at the ESO La Silla Observatory [1]. Operated from Liège (Belgium) it is devoted to the detection and characterisation of exoplanets and to the study of comets and other small bodies in the Solar System. We describe here the hardware and the goals of the project and give an overview of the comet production rates monitoring after three years of operations. The telescope and observatory --- TRAPPIST's optical tube unit is a Ritchey-Chretien 0.6 meter telescope with a focal length of 4.8 meter. It is associated with a German equatorial mount that is, thanks to its direct drive system, extremely fast (up to 50 deg/s), accurate (tracking accuracy without autoguider better than 2'' in 10 min), and free of periodic error. The instrument is a Peltier cooled commercial camera equipped with a Fairchild 3041 back-illuminated 2k×2k chip. The pixel scale is 0.64''/pixel. Three read-out modes are available, the shortest read-out time being 2s. The total field of view of the camera is 22'×22'. It is associated to a custom-made dual filter wheel. One of the filter wheel contains broad band filters (Johnson B, V, R, Cousins Ic, Sloan z, and a special I+z filter), while the other contains the narrow-band NASA HB cometary filters (OH, NH, CN, CO+, C3, and C2 gaseous species; UC, BC, GC and RC solar continuum windows and a NaI D filter) [2]. The telescope is protected by a 5 meter diameter dome that was totally refurbished and automatized. The observatory is fully robotic and equipped with a weather station, an UPS and webcams. The la Silla site is excellent with more than 300 clear nights per year and the telescope has proven to be very reliable with a small amount of technical downtime. Comet monitoring --- For relatively bright comets (V < 12) we measure several times a week the gaseous production rates (using a Haser model) and the spatial

  19. Star Formation at z~6: i-Dropouts in the Advanced Camera for Surveys Guaranteed Time Observation Fields

    NASA Astrophysics Data System (ADS)

    Bouwens, R. J.; Illingworth, G. D.; Rosati, P.; Lidman, C.; Broadhurst, T.; Franx, M.; Ford, H. C.; Magee, D.; Benítez, N.; Blakeslee, J. P.; Meurer, G. R.; Clampin, M.; Hartig, G. F.; Ardila, D. R.; Bartko, F.; Brown, R. A.; Burrows, C. J.; Cheng, E. S.; Cross, N. J. G.; Feldman, P. D.; Golimowski, D. A.; Gronwall, C.; Infante, L.; Kimble, R. A.; Krist, J. E.; Lesser, M. P.; Martel, A. R.; Menanteau, F.; Miley, G. K.; Postman, M.; Sirianni, M.; Sparks, W. B.; Tran, H. D.; Tsvetanov, Z. I.; White, R. L.; Zheng, W.

    2003-10-01

    Using an i-z dropout criterion, we determine the space density of z~6 galaxies from two deep ACS GTO fields with deep optical-IR imaging. A total of 23 objects are found over 46 arcmin2, or ~0.5+/-0.1 objects arcmin-2 down to zAB~27.3 (6 σ), or a completeness-corrected ~0.5+/-0.2 objects arcmin-2 down to zAB~26.5 (including one probable z~6 active galactic nucleus). Combining deep ISAAC data for our RDCS 1252-2927 field (JAB~25.7 and Ks,AB~25.0 5 σ) and NICMOS data for the Hubble Deep Field-North (J110,AB and H160,AB~27.3, 5 σ), we verify that these dropouts have relatively flat spectral slopes, as one would expect for star-forming objects at z~6. Compared with the average-color (β=-1.3) U-dropout in the Steidel et al. z~3 sample, i-dropouts in our sample range in luminosity from ~1.5L* (zAB~25.6) to ~0.3L* (zAB~27.3) with the exception of one very bright candidate at z850,AB~24.2. The half-light radii vary from 0.09" to 0.21", or 0.5 kpc to 1.3 kpc. We derive the z~6 rest-frame UV luminosity density (or star formation rate density) by using three different procedures. All three procedures use simulations based on a slightly lower redshift (z~5) V606-dropout sample from Chandra Deep Field-South ACS images. First, we make a direct comparison of our findings with a no-evolution projection of this V-dropout sample, allowing us to automatically correct for the light lost at faint magnitudes or lower surface brightnesses. We find 23%+/-25% more i-dropouts than we predict, consistent with no strong evolution over this redshift range. Adopting previous results to z~5, this works out to a mere 20%+/-29% drop in the luminosity density from z~3 to z~6. Second, we use the same V-dropout simulations to derive a detailed selection function for our i-dropout sample and compute the UV-luminosity density [(7.2+/-2.5)×1025 ergs s-1 Hz-1 Mpc-3 down to zAB~27]. We find a 39%+/-21% drop over the same redshift range (z~3-6), consistent with the first estimate. This is our

  20. Biorefinery Technologies for Biomass Conversion Into Chemicals and Fuels Towards Zero Emissions (Review) / Nulles Emisiju Princips Biomasas Konversijas Tehnoloģijās Aizstājot Fosilos Resursus (Pārskata Raksts)

    NASA Astrophysics Data System (ADS)

    Gravitis, J.; Abolins, J.

    2013-10-01

    Exhausting of world resources, increasing pollution, and climate change are compelling the shift of the world economy from continuous growth to a kind of economy based on integration of technologies into zero emissions production systems. Transition from non-renewable fossil resources to renewable resources provided by solar radiation and the current processes in biosphere is seen in the bio-refinery approach - replacing crude oil refineries by biomass refineries. Biotechnology and nano-technologies are getting accepted as important players along with conventional biomass refinery technologies. Systems design is a significant element in the integration of bio-refinery technologies in clusters. A number of case-studies, steam explosion auto-hydrolysis (SEA) in particular, are reviewed to demonstrate conversion of biomass into value-added chemicals and fuels. Analysis of energy flows is made as part of modelling the SEA processes, the eMergy (energy memory) approach and sustainability indices being applied to assess environmental impacts. Resursu izsīkums, vides piesārņojums un globāla mēroga klimatiskās izmaiņas ir civilizācijas izdzīvošanai būtiski faktori, kas virza pasaules ekonomikas pārmaiņas, atsakoties no nepārtrauktas izaugsmes idejas par labu tādai ekonomikai, kas balstās uz atjaunojošamies resursiem un dažādu tehnoloģiju integrācijemisiju principam atbilstošās ražošanas sistēmās. Saules radiācijas ierosinātajos planētas biosfērā notiekošajos procesos radīto organisko vielu pārstrādes kompleksi, kas operē ievērojot sabalansētu nulles emisiju principu, tiek uzlūkoti kā tās ekonomiskās (ražošanas) struktūras, kurām jānodrošina pāreja uz atjaunojošos resursu izmantošanu, aizstājot esošās fosilo resursu (naftas, ogļu) pārstrādes rūpnīcas. Līdzās jau apgūtajām biomasas rafinēšanas tehnoloģijām svarīga un pieaugoša loma ekonomiskās sistēmas resursu bāzes nomaiņā ir bio- un nanotehnolo

  1. Relativistic central-field Green's functions for the RATIP package

    NASA Astrophysics Data System (ADS)

    Koval, Peter; Fritzsche, Stephan

    2005-11-01

    /output CPU time required to execute test data: 2 min on a 450 MHz Pentium III processor No. of lines in distributed program, including test data etc.: 82 042 No. of bytes in distributed program, including test data etc.: 814 096 Distribution format: tar.gz Nature of the physical problem: In atomic perturbation theory, Green's functions may help carry out the summation over the complete spectrum of atom and ions, including the (summation over the) bound states as well as an integration over the continuum [R.A. Swainson, G.W.F. Drake, J. Phys. A 24 (1991) 95]. Analytically, however, these functions are known only for free electrons ( V(r)≡0) and for electrons in a pure Coulomb field ( V(r)=-Z/r). For all other choices of the potential, in contrast, the Green's functions must be determined numerically. Method of solution: Relativistic Green's functions are generated for an arbitrary central-field potential V(r)=-Z(r)/r by using a piecewise linear approximation of the effective nuclear charge function Z(r) on some grid r(i=1,…,N): Z(r)=Z0i+Z1ir. Then, following McGuire's algorithm [E.J. McGuire, Phys. Rev. A 23 (1981) 186], the radial Green's functions are constructed from the (two) linear-independent solutions of the homogeneous equation [P. Morse, H. Feshbach, Methods of Theoretical Physics, McGraw-Hill, New York 1953 (Part 1, p. 825)]. In the computation of these radial functions, the Kummer and Tricomi functions [J. Spanier, B. Keith, An Atlas of Functions, Springer, New York, 1987] are used extensively. Restrictions onto the complexity of the problem: The main restrictions of the program concern the shape of the effective nuclear charge Z(r)=-rV(r), i.e. the choice of the potential, and the allowed energies. Apart from obeying the proper boundary conditions for a point-like nucleus, namely, Z(r→0)=Z>0 and Z(r→∞)=Z-N⩾0, the first derivative of the charge function Z(r) must be smaller than the (absolute value of the) energy of the Green's function, {

  2. The atomic branching ratios in the photodissociation N2, CO, and CO2 in the deep VUV from 11.50-15.15 eV is used to discuss the chemistry in comets, planetary atmospheres, protoplanetary disk, and dense molecular clouds.

    NASA Astrophysics Data System (ADS)

    Jackson, William M.; Song, Yu; Lu, Zhou; Gao, Hong; Chang, Yih C.; Zhou, Jingang; Shi, Xiayou; Pan, Yang; Yang, Lei; Yin, Qing Z.; Ng, Cheuk Y.

    2014-11-01

    The only pulsed molecular beam apparatus in the world with two tunable VUV lasers coupled to a time of flight mass spectrometer and a time-slice velocity imaging detector is used to determine the state of atomic products produced in the photodissociation of N2, CO, and CO2. This information is extremely important in modeling the chemistry in comets, planetary atmospheres, protoplanetary disk, and dense molecular clouds. For N2 reactions 2-4 are directly observed.N2 + hν → N(4S) + N(4S) hν ≥ 9.76 eV (1)→ N(4S) + N(2D) hν ≥ 12.14 eV (2)→ N(4S) + N(2P) hν ≥ 13.34 eV (3)→ N(2D) + N(2D) hν ≥ 14.53 eV (4)No evidence is found for the lowest energy channel that produces two N(4S) anywhere in this wavelength range.The products from the photodissociation of CO between 12.361-13.180 eV are determined and discussed.CO + hν → C(3PJ) + O(3PJ) hν ≥ 11.09 eV (5)→ C(1D) + O(3PJ) hν ≥ 12.35 eV (6)→ C(3PJ) + O(1D) hν ≥ 13.06 eV (7) In the photodissociation of CO2 over the wavelength range from 94,000- 98,496 cm-1 (11.655-12.212eV) and (13.540-13.678 eV) CO2 reactions 8-15 occur.CO2 + hν → (O3PJ) + CO(X1Σ +) hν ≥ 5.45 eV (8)→ O(1D) + CO(X1Σ+) hν ≥ 7.42 eV (9)→ O(1S) + CO(X1Σ+) hν ≥ 9.64 eV (10)→ O(3PJ) + CO(a3Π) hν ≥ 11.46 eV (11)→ O(1D) + CO(a3Π) hν ≥ 13.43 eV (12)→ O(3PJ) + CO(a'3Σ+) hν ≥ 12.31 eV (13)→ O(3PJ) + CO(d 3Δ) hν ≥ 12.97 eV (14)→ O(3PJ) + CO(e 3Σ-) hν ≥ 13.35 eV (15)The implications of these results to planetary science in terms of the chemical reactions of the long lived metastable N(2D), N(2P), O(1D), O(1S), and C(1D) will be discussed. Acknowledgements:William M. Jackson, Yu Song, Hong Gao, Xiayou Shi and Zhou Lu were supported NSF under Grants No. CHE-1301501 and CHE-957872. Cheuk Y. Ng was supported by US-DOE under Contract No. DE-FG02-02ER15306.

  3. Origin of the Honolulu Volcanics Series (Oahu, Hawaii) From High Precision Pb Isotope Data

    NASA Astrophysics Data System (ADS)

    Fekiacova, Z.; Abouchami, W.; Galer, S. J.; Garcia, M. O.

    2005-12-01

    sampled by subaerial Makapuu lavas but recurrent in the main shield lavas, (2) a radiogenic Pb component, similar to the ''Kea-lo8'' of [5] common to the main-shield (KSDP) and HVS lavas, and (3) a depleted component unique to the rejuvenated HVS. The relatively uniform isotopic compositions of this ''depleted'' component (low 87Sr/86Sr, high 143Nd/144Nd) and, particularly its Pb isotopic composition, definitively rule out any involvement of Pacific lithosphere in the HVS. We conclude that the Hawaiian ''rejuvenated depleted'' component is intrinsic to the Hawaiian plume, probably thermally entrained by the upwelling plume during its ascent [6]. 1. Frey et al. Geochem. Geophys. Geosyst., 6(1), (2004GC000757), 2005 2. Fekiacova, Z. and Abouchami, W., Eos Trans. AGU, 84(46), Fall Meet. Suppl., Abstract V32A-0991, 2003. 3. Abouchami et al., Nature 434, 851-856, 2005 4. Galer, S.J.G. et al., Eos Trans. AGU, 80(46), Fall Meet. Suppl., Abstract V11E-08, 1999 5. Eisele et al., Geochem. Geophys. Geosyst., 4(2), doi:10.1029/2002GC000339, 2003 6. Ribe N.M. and Christensen U.R. Earth Planet. Sci. Letters 171, 517-531, 1999

  4. Pb Isotopic Evolution of Koolau Volcano (Oahu, Hawaii)

    NASA Astrophysics Data System (ADS)

    Fekiacova, Z.; Abouchami, W.

    2003-12-01

    lavas samples a plume component which apparently persisted during the post-erosional stage. The unradiogenic Pb component present in Honolulu lavas has Pb isotope characteristics that are clearly distinct from those of East Pacific Rise MORB [4], suggesting that it may not be derived from the underlying Hawaiian lithosphere. Available isotopic data on the oceanic crust basement near Hawaii [5] are unreliable, making a direct comparison difficult. While the Hawaiian lithosphere hypothesis cannot be entirely ruled out, we suggest that the unradiogenic Honolulu Pb component reflects material thermally entrained by the upwelling plume during its ascent and is essentially sampled during the post-erosional stage of Hawaiian volcanism. 1.Abouchami, W. et al., Eos Trans. AGU, 81 (48), Fall Meet. Suppl., Abstract V21D-03, 2000b 2.Eisele, J. et al., Geochem. Geophys. Geosyst., 4(2), 8710, doi:10.1029/2002GC000339, 2003 3.Tanaka, R. and Nakamura, E., Geophys. Monograph Ser., vol. 128, 311-332, 2002 4.Galer, S.J.G. et al., Eos Trans. AGU, 80 (46), Fall Meet. Suppl., Abstract V11E-08, 1999 5.King et al., Proc. ODP, Sci. Results., 136, 1993, 107-118

  5. Lidar-based biomass assessment for the Yukon River Basin

    NASA Astrophysics Data System (ADS)

    Peterson, B.; Wylie, B. K.; Stoker, J.; Nossov, D.

    2010-12-01

    lidar data set and are expected to result in improved biomass products for the YRB as they have been shown to be highly predictive of biomass in other biomes. The results of this project represent the first step in a larger effort to collect lidar and field data for various study sites across the YRB for biomass estimations to train large-scale mapping efforts using Landsat imagery and radar data. Bond-Lamberty, B., C. Wang, and S.T. Gower. 2002. Aboveground and belowground biomass and sapwood area allometric equations for six boreal tree species of northern Manitoba. Canadian Journal of Forest Research 32: 1441-1450. Mack, M., K. Treseder, K. Manies, J. Harden, E. Schuur, J. Vogel, J. Randerson, and F.S. Chapin III. 2008. Recovery of Aboveground Plant Biomass and Productivity After Fire in Mesic and Dry Black Spruce Forests of Interior Alaska, Ecosystems v.11:209-225. Yarie, J., E. Kane, and M. Mack. 2007. Aboveground Biomass Equations for the Trees of Interior Alaska. AFES Bulletin 115.

  6. Geologic Map and Eruptive History of Veniaminof Volcano Record Aleutian Arc Processing of Mantle-Derived Melts

    NASA Astrophysics Data System (ADS)

    Bacon, C. R.; Sisson, T. W.; Calvert, A. T.; Nye, C. J.

    2009-12-01

    dacitic pyroclastic-flow deposit on the northwest flank, sandwiched between 46±1-ka dacite and 28±4-ka andesite lava flows, may record early caldera collapse as also evidenced by thick 33±6-ka ice-chilled dacite lava that must have banked against ice in a depression spatially coincident with the northwest part of the present caldera. The modern caldera formed, or was enlarged, during two voluminous Holocene explosive eruptions of crystal-poor andesite ~3700 14C yr BP and >4700 14C yr BP (Miller et al., 2002 Fall AGU, V11A-1376) that emplaced pyroclastic-flow deposits on Veniaminof's flanks and in surrounding valleys. Frequent eruption from shallow reservoirs may suppress accumulation of more than a few km3 of dacitic magma at Veniaminof.

  7. Numerical Modeling of Thermal Pollution of Large Water Bodies from Thermal and Nuclear Power Plants

    NASA Astrophysics Data System (ADS)

    Lyubimova, Tatyana; Lepikhin, Anatoly; Lyakhin, Yury; Parshakova, Yanina; Tiunov, Alexey

    2016-04-01

    Currently, the major manufacturers of electrical energy are the thermal and nuclear power plants including the cooling ponds in the processing chains. For a wide range of both environmental and technological problems, the evaluation of the temperature fields in the cooling ponds at certain critical values of hydrological and meteorological parameters is important. The present paper deals with the evaluation of the thermal effect of one of the largest thermal power plant in Europe - Perm GRES - to its cooling pond which is the Kama Reservoir. Since the area of the possible impact is rather large and the reservoir itself is characterized by a very complex morphometry, numerical modeling of thermal spot propagation in the Kama River due to the discharge of warm water by Perm GRES for the entire area in the 3D-formulation with the desired detail setting morphometric characteristics of the water body meets very serious difficulties. Because of that, to solve the problem, a combined scheme of calculations based on the combination of hydrodynamic models in 2D and 3D formulations was used. At the first stage of the combined scheme implementation, 2D hydrodynamical model was developed for all possible area, using software SMS v.11.1. The boundary and initial conditions for this model were formulated on the basis of calculations made using 1D hydrodynamical model developed and applied for the entire Kama Reservoir. Application of 2D hydrodynamical model for solving the problem under consideration was needed to obtain the necessary information for setting the boundary conditions for the 3D model. Software package ANSYS Fluent v.6.3 was used for the realization of 3D model. 3D modeling was performed for different wind speeds and directions and quantitative characteristics of the discharge of warm water. To verify the models, the data of the detailed field measurements in the zones of thermal pollution of the Kama reservoir due to impact of the Perm GRES were used. A

  8. Outbursts In Symbiotic Binaries (FUSE 2000)

    NASA Technical Reports Server (NTRS)

    Kenyon, Scott J.; Sonneborn, George (Technical Monitor)

    2002-01-01

    During the past year, we made good progress on analysis of FUSE observations of the symbiotic binary Z And. For background, Z And is a binary system composed of a red giant and a hot component of unknown status. The orbital period is roughly 750 days. The hot component undergoes large-scale eruptions every 10-20 yr. An outburst began several years ago, triggering this FUSE opportunity. First, we obtained an excellent set of ground-based optical data in support, of the FUSE observations. We used FAST, a high throughput low resolution spectrograph on the 1.5-m telescope at Mt. Hopkins, Arizona. A 300 g/ mm grating blazed at 4750 A, a 3 in. slit, and a thinned Loral 512 x 2688 CCD gave us spectra covering 3800-7500 A at a resolution of 6 A. The wavelength solution for each spectrum has a probable error of +/- 0.5 A or better. Most of the resulting spectra have moderate signal-to-noise, S/.N approx. greater than 30 per pixel. The time coverage for these spectra is excellent. Typically, we acquired spectra every 1-2 nights during dark runs at Mt. Hopkins. These data cover most of the rise and all of the decline of the recent outburst. The spectra show a wealth of emission lines, including H I, He I, He II, [Fe V11], and the Raman scattering bands at 6830 A and 7088 A. The Raman bands and other high ionization features vary considerably throughout the outburst. These features will enable us to correlate variations in the FUSE spectra with variations in the optical spectra. Second, we began an analysis of FUSE spectra of Z And. We have carefully examined the spectra, identifying real features and defects. We have identified and measured fluxes for all strong emission lines, including the O VI doublet at 1032 A and 1038 A. These and several other strong emission lines display pronounced P Cygni absorption components indicative of outgrowing gas. We will attempt to correlate these velocities with similar profiles observed on optical spectra. The line velocities - together

  9. Analysis of astronomy knowledge of the students in the Federal Institute Sao Paulo

    NASA Astrophysics Data System (ADS)

    Moraes, A. C.; Voelzke, M. R.

    2014-08-01

    abordados e os alunos obtiveram uma melhora significativa no aprendizado dos conceitos relacionados à astronomia. Nota-se que a astronomia está presente e é elemento importante dos parâmetros curriculares nacionais e que há muito interesse por parte dos alunos com relação ao tema. Diante dos resultados obtidos no pós-curso, pode-se afirmar que o curso básico em astronomia, realizado na própria escola, mas externo ao conteúdo programático, proporcionou uma integração entre os alunos, estreitando os laços de amizade e do conhecimento entre eles não importando a turma ou o período pois a dificuldade inicial foi vencida por todos, com muita dedicação e comprometimento entre todos; hoje estes alunos podem seguramente continuar estudando estes conceitos de astronomia. ALBRECHT, E.; VOELZKE, M. R.Teaching of Astronomy and scientific literacy. Journal of Science Education, v. 11, n. 1, p.35-38, 2010.

  10. Characterization of the flowing afterglows of an N2 O2 reduced-pressure discharge: setting the operating conditions to achieve a dominant late afterglow and correlating the NOβ UV intensity variation with the N and O atom densities

    NASA Astrophysics Data System (ADS)

    Boudam, M. K.; Saoudi, B.; Moisan, M.; Ricard, A.

    2007-03-01

    The flowing afterglow of an N2-O2 discharge in the 0.6-10 Torr range is examined in the perspective of achieving sterilization of medical devices (MDs) under conditions ensuring maximum UV intensity with minimum damage to polymer-based MDs. The early afterglow is shown to be responsible for creating strong erosion damage, requiring that the sterilizer be operated in a dominant late-afterglow mode. These two types of afterglow can be characterized by optical emission spectroscopy: the early afterglow is distinguished by an intense emission from the N_{2}^{+} 1st negative system (band head at 391.4 nm) while the late afterglow yields an overpopulation of the v' = 11 ro-vibrational level of the N2(B) state, indicating a reduced contribution from the early afterglow N2 metastable species. We have studied the influence of operating conditions (pressure, O2 content in the N2-O2 mixture, distance of the discharge from the entrance to the afterglow (sterilizer) chamber) in order to achieve a dominant late afterglow that also ensures maximum and almost uniform UV intensity in the sterilization chamber. As far as operating conditions are concerned, moving the plasma source sufficiently far from the chamber entrance is shown to be a practical means for significantly reducing the density of the characteristic species of the early afterglow. Using the NO titration method, we obtain the (absolute) densities of N and O atoms in the afterglow at the NO injection inlet, a few cm before the chamber entrance: the N atom density goes through a maximum at approximately 0.3-0.5% O2 and then decreases, while the O atom density increases regularly with the O2 percentage. The spatial variation of the N atom (relative) density in the chamber is obtained by recording the emission intensity from the 1st positive system at 580 nm: in the 2-5 Torr range, this density is quite uniform everywhere in the chamber. The (relative) densities of N and O atoms in the discharge are determined by using

  11. The web system for operative description of air quality in the city

    NASA Astrophysics Data System (ADS)

    Barth, A. A.; Starchenko, A. V.; Fazliev, A. Z.

    2009-04-01

    geostrophic wind components on the base of Eckman equations; The applications for solution of the equations derived from ABL and transport of impurity models. The application for representation of calculation results in tabular and graphical forms. "Cyberia" cluster [6] located in Tomsk State University is used for computation of the impurity transport equations. References: Gordov E.P., V. N. Lykosov, and A. Z. Fazliev, Web portal on environmental sciences "ATMOS"// Advances in Geoscience, 2006, v. 8, p. 33-38. ATMOS web-portal http://atmos.iao.ru/middleware/ Belikov D.A., Starchenko A.V. Numerical investigation of secondary air pollutions formation near industrial center // Computational technologies. 2005. V. 10. Special issue. Proceedings of the International Conference and the School of Young Scientists "Computational and informational technologies for environmental sciences" (CITES 2005). Tomsk, 13-23 March 2005. Part 2. P. 99-105 Sudo, K., Takahashi M., Kurokawa J., Akimoto H. CHASER: A global chemical model of the troposphere. Model description, J. Geophys. Res., 2002, Vol.107(D17), P. 4339. Tolstykh M.A., Fadeev R.Y. Semi-Lagrangian variable-resolution weather prediction model and its further development // Computational technologies. 2006. V. 11. Special issue. P. 176-184 ATMOS web-portal http://climate.atmos.math.tsu.ru/ Tomsk state university, Interregional computational center http://skif.tsu.ru

  12. Impact of dose calculation accuracy during optimization on lung IMRT plan quality.

    PubMed

    Li, Ying; Rodrigues, Anna; Li, Taoran; Yuan, Lulin; Yin, Fang-Fang; Wu, Q Jackie

    2015-01-01

    The purpose of this study was to evaluate the effect of dose calculation accuracy and the use of an intermediate dose calculation step during the optimization of intensity-modulated radiation therapy (IMRT) planning on the final plan quality for lung cancer patients. This study included replanning for 11 randomly selected free-breathing lung IMRT plans. The original plans were optimized using a fast pencil beam convolution algorithm. After optimization, the final dose calculation was performed using the analytical anisotropic algorithm (AAA). The Varian Treatment Planning System (TPS) Eclipse v11, includes an option to perform intermediate dose calculation during optimization using the AAA. The new plans were created using this intermediate dose calculation during optimization with the same planning objectives and dose constraints as in the original plan. Differences in dosimetric parameters for the planning target volume (PTV) dose coverage, organs-at-risk (OARs) dose sparing, and the number of monitor units (MU) between the original and new plans were analyzed. Statistical significance was determined with a p-value of less than 0.05. All plans were normalized to cover 95% of the PTV with the prescription dose. Compared with the original plans, the PTV in the new plans had on average a lower maximum dose (69.45 vs. 71.96Gy, p = 0.005), a better homogeneity index (HI) (0.08 vs. 0.12, p = 0.002), and a better conformity index (CI) (0.69 vs. 0.59, p = 0.003). In the new plans, lung sparing was increased as the volumes receiving 5, 10, and 30 Gy were reduced when compared to the original plans (40.39% vs. 42.73%, p = 0.005; 28.93% vs. 30.40%, p = 0.001; 14.11%vs. 14.84%, p = 0.031). The volume receiving 20 Gy was not significantly lower (19.60% vs. 20.38%, p = 0.052). Further, the mean dose to the lung was reduced in the new plans (11.55 vs. 12.12 Gy, p = 0.024). For the esophagus, the mean dose, the maximum dose, and the volumes receiving 20 and 60 Gy were lower in

  13. HAT-P-50b, HAT-P-51b, HAT-P-52b, and HAT-P-53b: Three Transiting Hot Jupiters and a Transiting Hot Saturn From the HATNet Survey

    NASA Astrophysics Data System (ADS)

    Hartman, J. D.; Bhatti, W.; Bakos, G. Á.; Bieryla, A.; Kovács, G.; Latham, D. W.; Csubry, Z.; de Val-Borro, M.; Penev, K.; Buchhave, L. A.; Torres, G.; Howard, A. W.; Marcy, G. W.; Johnson, J. A.; Isaacson, H.; Sato, B.; Boisse, I.; Falco, E.; Everett, M. E.; Szklenar, T.; Fulton, B. J.; Shporer, A.; Kovács, T.; Hansen, T.; Béky, B.; Noyes, R. W.; Lázár, J.; Papp, I.; Sári, P.

    2015-12-01

    We report the discovery and characterization of four transiting exoplanets by the HATNet survey. The planet HAT-P-50b has a mass of 1.35 {M}{{J}} and radius of 1.29 {R}{{J}}, and orbits a bright (V=11.8 mag) M=1.27 {M}⊙ , R=1.70 {R}⊙ star every P=3.1220 days. The planet HAT-P-51b has a mass of 0.31 {M}{{J}} and radius of 1.29 {R}{{J}}, and orbits a V=13.4 mag, M=0.98 {M}⊙ , R=1.04 {R}⊙ star with a period of P=4.2180 days. The planet HAT-P-52b has a mass of 0.82 {M}{{J}} and radius of 1.01 {R}{{J}}, and orbits a V=14.1 mag, M=0.89 {M}⊙ , R=0.89 {R}⊙ star with a period of P=2.7536 days. The planet HAT-P-53b has a mass of 1.48 {M}{{J}} and radius of 1.32 {R}{{J}}, and orbits a V=13.7 mag, M=1.09 {M}⊙ , R=1.21 {R}⊙ star with a period of P=1.9616 days. All four planets are consistent with having circular orbits and have masses and radii measured to better than 10% precision. The low stellar jitter and favorable {R}p/{R}\\star ratio for HAT-P-51 make it a promising target for measuring the Rossiter-McLaughlin effect for a Saturn-mass planet. Based on observations obtained with the Hungarian-made Automated Telescope Network. Based on observations obtained at the W. M. Keck Observatory, which is operated by the University of California and the California Institute of Technology. Keck time has been granted by NOAO (A245Hr) and NASA (N154Hr, N130Hr). Based on data collected at Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. Based on observations made with the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, Sweden, in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias. Based on observations obtained with the Tillinghast Reflector 1.5 m telescope and the 1.2 m telescope, both operated by the Smithsonian Astrophysical Observatory at the Fred Lawrence Whipple Observatory in AZ. Based on radial velocities obtained with the

  14. Carbonyl compounds emitted by a diesel engine fuelled with diesel and biodiesel-diesel blends: Sampling optimization and emissions profile

    NASA Astrophysics Data System (ADS)

    Guarieiro, Lílian Lefol Nani; Pereira, Pedro Afonso de Paula; Torres, Ednildo Andrade; da Rocha, Gisele Olimpio; de Andrade, Jailson B.

    75). The ΣCC of the emission concentrations were 20.5 ppmV for B0 and 15.7 ppmV for B100. When considering fuel blends, the measured ΣCC were 21.4 ppmV, 22.5 ppmV, 20.4 ppmV, 14.2 ppmV, 11.4 ppmV and 14.7 ppmV, respectively, for B2, B5, B10, B20, B50 and B75. Among the target CC, both formaldehyde and acetaldehyde were the major contributors to the observed total CC levels. Except for acrolein and formaldehyde, all CC showed a clear trend of reduction in the emissions from B2 to B100 (40% reduction, on average). Both individual and total CC emission factors (pg g -1 of fuel burnt) were calculated for all tested biodiesel-diesel blends. The lowest total CC emission factor (2271 pg g -1) was found when B50 was used; the individual emission factors determined (pg g -1) were: 539.7 (formaldehyde), 1411 (acetaldehyde), 30.83 (acrolein), and 310.7 (propionaldehyde).

  15. Stereotactic Arrhythmia Radioablation (STAR) of Ventricular Tachycardia: A Treatment Planning Study

    PubMed Central

    Fahimian, Benjamin; Soltys, Scott G; Zei, Paul; Lo, Anthony; Gardner, Edward A; Maguire, Patrick J; Loo Jr., Billy W

    2016-01-01

    Purpose The first stereotactic arrhythmia radioablation (STAR) of ventricular tachycardia (VT) was delivered at Stanford on a robotic radiosurgery system (CyberKnife® G4) in 2012. The results warranted further investigation of this treatment. Here we compare dosimetrically three possible treatment delivery platforms for STAR. Methods The anatomy and target volume of the first treated patient were used for this study. A dose of 25 Gy in one fraction was prescribed to the planning target volume (PTV). Treatment plans were created on three treatment platforms: CyberKnife® G4 system with Iris collimator (Multiplan, V. 4.6)(Plan #1), CyberKnife® M6 system with InCise 2TM multileaf collimator (Multiplan V. 5.3)(Plan #2) and Varian TrueBeamTM STx with HD 120TM MLC and 10MV flattening filter free (FFF) beam (Eclipse planning system, V.11) (Plan #3 coplanar and #4 noncoplanar VMAT plans). The four plans were compared by prescription isodose line, plan conformity index, dose gradient, as well as dose to the nearby critical structures. To assess the delivery efficiency, planned monitor units (MU) and estimated treatment time were evaluated. Results Plans #1-4 delivered 25 Gy to the PTV to the 75.0%, 83.0%, 84.3%, and 84.9% isodose lines and with conformity indices of 1.19, 1.16, 1.05, and 1.05, respectively. The dose gradients for plans #1-4 were 3.62, 3.42, 3.93, and 3.73 with the CyberKnife® MLC plan (Plan #2) the best, and the TrueBeamTM STx co-planar plan (Plan #3) the worst. The dose to nearby critical structures (lung, stomach, bowel, and esophagus) were all well within tolerance. The MUs for plans #1-4 were 27671, 16522, 6275, and 6004 for an estimated total-treatment-time/beam-delivery-time of 99/69, 65/35, 37/7, and 56/6 minutes, respectively, under the assumption of 30 minutes pretreatment setup time. For VMAT gated delivery, a 40% duty cycle, 2400MU/minute dose rate, and an extra 10 minutes per extra arc were assumed. Conclusion Clinically acceptable plans were

  16. Launch Pad Flame Trench Refractory Materials

    NASA Technical Reports Server (NTRS)

    Calle, Luz M.; Hintze, Paul E.; Parlier, Christopher R.; Bucherl, Cori; Sampson, Jeffrey W.; Curran, Jerome P.; Kolody, Mark; Perusich, Steve; Whitten, Mary

    2010-01-01

    The launch complexes at NASA's John F. Kennedy Space Center (KSC) are critical support facilities for the successful launch of space-based vehicles. These facilities include a flame trench that bisects the pad at ground level. This trench includes a flame deflector system that consists of an inverted, V-shaped steel structure covered with a high temperature concrete material five inches thick that extends across the center of the flame trench. One side of the "V11 receives and deflects the flames from the orbiter main engines; the opposite side deflects the flames from the solid rocket boosters. There are also two movable deflectors at the top of the trench to provide additional protection to shuttle hardware from the solid rocket booster flames. These facilities are over 40 years old and are experiencing constant deterioration from launch heat/blast effects and environmental exposure. The refractory material currently used in launch pad flame deflectors has become susceptible to failure, resulting in large sections of the material breaking away from the steel base structure and creating high-speed projectiles during launch. These projectiles jeopardize the safety of the launch complex, crew, and vehicle. Post launch inspections have revealed that the number and frequency of repairs, as well as the area and size of the damage, is increasing with the number of launches. The Space Shuttle Program has accepted the extensive ground processing costs for post launch repair of damaged areas and investigations of future launch related failures for the remainder of the program. There currently are no long term solutions available for Constellation Program ground operations to address the poor performance and subsequent failures of the refractory materials. Over the last three years, significant liberation of refractory material in the flame trench and fire bricks along the adjacent trench walls following Space Shuttle launches have resulted in extensive investigations of

  17. Titer-plate formatted continuous flow thermal reactors: Design and performance of a nanoliter reactor

    PubMed Central

    Chen, Pin-Chuan; Park, Daniel S.; You, Byoung-Hee; Kim, Namwon; Park, Taehyun; Soper, Steven A.; Nikitopoulos, Dimitris E.; Murphy, Michael C.

    2010-01-01

    Arrays of continuous flow thermal reactors were designed, configured, and fabricated in a 96-device (12 × 8) titer-plate format with overall dimensions of 120 mm × 96 mm, with each reactor confined to a 8 mm × 8 mm footprint. To demonstrate the potential, individual 20-cycle (740 nL) and 25-cycle (990 nL) reactors were used to perform the continuous flow polymerase chain reaction (CFPCR) for amplification of DNA fragments of different lengths. Since thermal isolation of the required temperature zones was essential for optimal biochemical reactions, three finite element models, executed with ANSYS (v. 11.0, Canonsburg, PA), were used to characterize the thermal performance and guide system design: (1) a single device to determine the dimensions of the thermal management structures; (2) a single CFPCR device within an 8 mm × 8 mm area to evaluate the integrity of the thermostatic zones; and (3) a single, straight microchannel representing a single loop of the spiral CFPCR device, accounting for all of the heat transfer modes, to determine whether the PCR cocktail was exposed to the proper temperature cycling. In prior work on larger footprint devices, simple grooves between temperature zones provided sufficient thermal resistance between zones. For the small footprint reactor array, 0.4 mm wide and 1.2 mm high fins were necessary within the groove to cool the PCR cocktail efficiently, with a temperature gradient of 15.8°C/mm, as it flowed from the denaturation zone to the renaturation zone. With temperature tolerance bands of ±2°C defined about the nominal temperatures, more than 72.5% of the microchannel length was located within the desired temperature bands. The residence time of the PCR cocktail in each temperature zone decreased and the transition times between zones increased at higher PCR cocktail flow velocities, leading to less time for the amplification reactions. Experiments demonstrated the performance of the CFPCR devices as a function of flow

  18. The osmoreceptor complex in the rat: evidence for interactions between the supraoptic and other diencephalic nuclei.

    PubMed

    Honda, K; Negoro, H; Dyball, R E; Higuchi, T; Takano, S

    1990-12-01

    1. Experiments were undertaken to provide evidence for the existence of a circuit of neuronal interconnections between the supraoptic nucleus (SON), the ventral anteroventral third ventricular region (including the organum vasculosum of the lamina terminalis; ventral AV3V) and the median preoptic nucleus (MnPO), and to determine the importance of these connections in the osmotic control of the neuronal activity of the SON. Extracellular recordings were made in the urethane-anaesthetized male rat from neurones in one of these three sites, while the other two sites were electrically stimulated. 2. During recording from the SON, electrical stimulus pulses applied either to the ventral AV3V or to the MnPO were followed by orthodromic excitation (OD+) or initial short-duration inhibition followed by long-duration excitation (OD- +) of most SON neurones (44/48). The latency of OD+ or OD+ component of OD- + response produced by electrical stimulation of the MnPO was significantly (paired t test, P less than 0.01) shorter than that by the stimulation of the ventral AV3V. None of the neurones we recorded in the SON was activated antidromically by stimulation of either the ventral AV3V or the MnPO. Pressure injection of lidocaine (10%, 50 nl) into the MnPO reversibly depressed the OD+ effect after stimulation of the ventral AV3V in all the SON neurones tested (11/11), while injection of lidocaine into the ventral AV3V did not affect the OD+ effect after stimulation of the MnPO in most neurones (7/9). Both types of observation are consistent with the presence of an excitatory input to SON through the MnPO. 3. Pressure injection of lidocaine into both the ventral AV3V and the MnPO reversibly blocked the activation of SON neurones following an I.P. injection of 1.5 M-NaCl (1 ml) (ventral AV3V 11/11; MnPO, 10/10 cells tested). Injection of lidocaine at both sites, however, did not prevent activation of SON neurones by hypovolaemia (2 ml of blood was withdrawn through a cannula

  19. Symbiotic variable V4018 Sgr in outburst

    NASA Astrophysics Data System (ADS)

    Elizabeth O. Waagen

    2012-09-01

    The symbiotic variable V4018 Sgr is undergoing an outburst, according to observations reported to the AAVSO and confirmed by spectroscopy by Ulisse Munari et al. Prompted by an observation and comment from John Bortle (Stormville, NY) (16 June 2012, visual magnitude 12.2) about a possible outburst, Steven O'Connor (St. George's, Bermuda) obtained an observation (10 August 2012, 11.44V) that confirmed V4018 Sgr was bright. His subsequent BVRI observations in September and visual observations by Bortle and Andrew Pearce (Nedlands, Western Australia) show the system brightening and at V magnitude 11.07 as of 2012 Sep. 17.091 UT. Ulisse Munari (INAF Astr. Obs. Padua, Italy) and colleagues Paolo Valisa and Sergio Dallaporta (ANS Collaboration), after being informed by the AAVSO of the bright state of V4018 Sgr, carried out spectroscopy. Munari writes: "A low resolution, absolutely fluxed 4000-8650 Ang spectrum of V4018 Sgr was obtained on Sept 13.90 UT with the 0.6m telescope ! of the Schiaparelli Observatory in Varese (Italy). It shows the spectrum of the M giant overwhelmed by a blue continuum up to 6000 Ang, and all high ionization emission lines typical of quiescence are gone, leaving only hydrogen Balmer and weak HeI lines in emission. The spectrum looks like a template one for a symbiotic star in outburst. CCD photometry was obtained on Sept 13.79 UT and provides V=11.027 ± 0.002, B-V=+0.621 ± 0.003. The B-V color is appreciably bluer and the V magnitude much brighter than typical in quiescence (on average V=13.3, B-V=+1.09; Henden and Munari 2008, Baltic Astronomy 17, 293), and support the idea V4018 Sgr is undergoing an outburst." According to Munari, the last bright outburst of V4018 Sgr was underway in June 1990. Observations in the AAVSO International Database from Albert Jones (Nelson, New Zealand) beginning in May 1992 show the variable at visual magnitude 11.0, with fluctuations between 10.5 and 11.9 through October 1995. Numerous ! other observers

  20. A Comparison of Observationally Determined Radii with Theoretical Radius Predictions for Short-Period Transiting Extrasolar Planets

    NASA Astrophysics Data System (ADS)

    Laughlin, Gregory; Wolf, Aaron; Vanmunster, Tonny; Bodenheimer, Peter; Fischer, Debra; Marcy, Geoff; Butler, Paul; Vogt, Steve

    2005-03-01

    Two extrasolar planets, HD 209458b and TrES-1, are currently known to transit bright parent stars for which physical properties can be accurately determined. The two transiting planets have very similar masses and periods and hence invite detailed comparisons between their observed and theoretically predicted properties. In this paper, we carry out these comparisons. We first report photometric and spectroscopic follow-up observations of TrES-1, and we use these observations to obtain improved estimates for the planetary radius, Rpl=(1.08+/-0.05)RJ, and the planetary mass, Mpl=(0.729+/-0.036)MJ. We also confirm that the inclination estimate of the planetary orbit as i=88.2d. These values agree with those obtained by Alonso et al. in their discovery paper, but the uncertainty in the planet radius has been improved as a result of both high-cadence photometry of two full transits and from independent radius determinations for the V=11.8 K0 V parent star. We derive estimates for the TrES-1 stellar parameters of R*/Rsolar=0.83+/-0.03 (by combining independent estimates from stellar models, high-resolution spectra, and transit light curve fitting) M*/Msolar=0.87+/-0.05 (via fitting to evolutionary tracks), Teff=5214+/-23K, [Me/H]=0.001+/-0.04, rotational velocity Vsin(i)=1.08+/-0.3kms-1, logg=4.52+/-0.05dex, logL*/Lsolar=-0.32, d=157+/-6pc, and an age of τ=4+/-2Gyr. These estimates of the physical properties of the system allow us to compute evolutionary models for the planet that result in a predicted radius of Rpl=1.05RJ for a model that contains an incompressible 20 M⊕ core and a radius Rpl=1.09RJ for a model without a core. We use our grids of planetary evolution models to show that, with standard assumptions, our code also obtains good agreement with the observed radii of the other recently discovered transiting planets, including OGLE-TR-56b, OGLE-TR-111b, OGLE-TR-113b, and OGLE-TR-132b. We report an updated radius for HD 209458b of Rpl=(1.32+/-0.05)RJ, based on

  1. Changes realized from extended bit-depth and metal artifact reduction in CT

    SciTech Connect

    Glide-Hurst, C.; Chen, D.; Zhong, H.; Chetty, I. J.

    2013-06-15

    Purpose: High-Z material in computed tomography (CT) yields metal artifacts that degrade image quality and may cause substantial errors in dose calculation. This study couples a metal artifact reduction (MAR) algorithm with enhanced 16-bit depth (vs standard 12-bit) to quantify potential gains in image quality and dosimetry. Methods: Extended CT to electron density (CT-ED) curves were derived from a tissue characterization phantom with titanium and stainless steel inserts scanned at 90-140 kVp for 12- and 16-bit reconstructions. MAR was applied to sinogram data (Brilliance BigBore CT scanner, Philips Healthcare, v.3.5). Monte Carlo simulation (MC-SIM) was performed on a simulated double hip prostheses case (Cerrobend rods embedded in a pelvic phantom) using BEAMnrc/Dosxyz (400 000 0000 histories, 6X, 10 Multiplication-Sign 10 cm{sup 2} beam traversing Cerrobend rod). A phantom study was also conducted using a stainless steel rod embedded in solid water, and dosimetric verification was performed with Gafchromic film analysis (absolute difference and gamma analysis, 2% dose and 2 mm distance to agreement) for plans calculated with Anisotropic Analytic Algorithm (AAA, Eclipse v11.0) to elucidate changes between 12- and 16-bit data. Three patients (bony metastases to the femur and humerus, and a prostate cancer case) with metal implants were reconstructed using both bit depths, with dose calculated using AAA and derived CT-ED curves. Planar dose distributions were assessed via matrix analyses and using gamma criteria of 2%/2 mm. Results: For 12-bit images, CT numbers for titanium and stainless steel saturated at 3071 Hounsfield units (HU), whereas for 16-bit depth, mean CT numbers were much larger (e.g., titanium and stainless steel yielded HU of 8066.5 {+-} 56.6 and 13 588.5 {+-} 198.8 for 16-bit uncorrected scans at 120 kVp, respectively). MC-SIM was well-matched between 12- and 16-bit images except downstream of the Cerrobend rod, where 16-bit dose was {approx}6

  2. Transiting exoplanets from the CoRoT space mission. VIII. CoRoT-7b: the first super-Earth with measured radius

    NASA Astrophysics Data System (ADS)

    Léger, A.; Rouan, D.; Schneider, J.; Barge, P.; Fridlund, M.; Samuel, B.; Ollivier, M.; Guenther, E.; Deleuil, M.; Deeg, H. J.; Auvergne, M.; Alonso, R.; Aigrain, S.; Alapini, A.; Almenara, J. M.; Baglin, A.; Barbieri, M.; Bruntt, H.; Bordé, P.; Bouchy, F.; Cabrera, J.; Catala, C.; Carone, L.; Carpano, S.; Csizmadia, Sz.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Foing, B.; Fressin, F.; Gandolfi, D.; Gillon, M.; Gondoin, Ph.; Grasset, O.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Lammer, H.; Llebaria, A.; Loeillet, B.; Mayor, M.; Mazeh, T.; Moutou, C.; Pätzold, M.; Pont, F.; Queloz, D.; Rauer, H.; Renner, S.; Samadi, R.; Shporer, A.; Sotin, Ch.; Tingley, B.; Wuchterl, G.; Adda, M.; Agogu, P.; Appourchaux, T.; Ballans, H.; Baron, P.; Beaufort, T.; Bellenger, R.; Berlin, R.; Bernardi, P.; Blouin, D.; Baudin, F.; Bodin, P.; Boisnard, L.; Boit, L.; Bonneau, F.; Borzeix, S.; Briet, R.; Buey, J.-T.; Butler, B.; Cailleau, D.; Cautain, R.; Chabaud, P.-Y.; Chaintreuil, S.; Chiavassa, F.; Costes, V.; Cuna Parrho, V.; de Oliveira Fialho, F.; Decaudin, M.; Defise, J.-M.; Djalal, S.; Epstein, G.; Exil, G.-E.; Fauré, C.; Fenouillet, T.; Gaboriaud, A.; Gallic, A.; Gamet, P.; Gavalda, P.; Grolleau, E.; Gruneisen, R.; Gueguen, L.; Guis, V.; Guivarc'h, V.; Guterman, P.; Hallouard, D.; Hasiba, J.; Heuripeau, F.; Huntzinger, G.; Hustaix, H.; Imad, C.; Imbert, C.; Johlander, B.; Jouret, M.; Journoud, P.; Karioty, F.; Kerjean, L.; Lafaille, V.; Lafond, L.; Lam-Trong, T.; Landiech, P.; Lapeyrere, V.; Larqué, T.; Laudet, P.; Lautier, N.; Lecann, H.; Lefevre, L.; Leruyet, B.; Levacher, P.; Magnan, A.; Mazy, E.; Mertens, F.; Mesnager, J.-M.; Meunier, J.-C.; Michel, J.-P.; Monjoin, W.; Naudet, D.; Nguyen-Kim, K.; Orcesi, J.-L.; Ottacher, H.; Perez, R.; Peter, G.; Plasson, P.; Plesseria, J.-Y.; Pontet, B.; Pradines, A.; Quentin, C.; Reynaud, J.-L.; Rolland, G.; Rollenhagen, F.; Romagnan, R.; Russ, N.; Schmidt, R.; Schwartz, N.; Sebbag, I.; Sedes, G.; Smit, H.; Steller, M. B.; Sunter, W.; Surace, C.; Tello, M.; Tiphène, D.; Toulouse, P.; Ulmer, B.; Vandermarcq, O.; Vergnault, E.; Vuillemin, A.; Zanatta, P.

    2009-10-01

    Aims: We report the discovery of very shallow (Δ F/F ≈ 3.4× 10-4), periodic dips in the light curve of an active V = 11.7 G9V star observed by the CoRoT satellite, which we interpret as caused by a transiting companion. We describe the 3-colour CoRoT data and complementary ground-based observations that support the planetary nature of the companion. Methods: We used CoRoT colours information, good angular resolution ground-based photometric observations in- and out- of transit, adaptive optics imaging, near-infrared spectroscopy, and preliminary results from radial velocity measurements, to test the diluted eclipsing binary scenarios. The parameters of the host star were derived from optical spectra, which were then combined with the CoRoT light curve to derive parameters of the companion. Results: We examined all conceivable cases of false positives carefully, and all the tests support the planetary hypothesis. Blends with separation >0.40´´or triple systems are almost excluded with a 8 × 10-4 risk left. We conclude that, inasmuch we have been exhaustive, we have discovered a planetary companion, named CoRoT-7b, for which we derive a period of 0.853 59 ± 3 × 10-5 day and a radius of Rp = 1.68 ± 0.09 R_Earth. Analysis of preliminary radial velocity data yields an upper limit of 21 M_Earth for the companion mass, supporting the finding. Conclusions: CoRoT-7b is very likely the first Super-Earth with a measured radius. This object illustrates what will probably become a common situation with missions such as Kepler, namely the need to establish the planetary origin of transits in the absence of a firm radial velocity detection and mass measurement. The composition of CoRoT-7b remains loosely constrained without a precise mass. A very high surface temperature on its irradiated face, ≈1800-2600 K at the substellar point, and a very low one, ≈50 K, on its dark face assuming no atmosphere, have been derived. The CoRoT space mission, launched on 27

  3. Intrastromal Corneal Ring Implants for Corneal Thinning Disorders

    PubMed Central

    2009-01-01

    . Search results were limited to human and English-language published between January 2000 and April 17, 2008. The resulting citations were downloaded into Reference Manager, v.11 (ISI Researchsoft, Thomson Scientific, U.S.A), and duplicates were removed. The Web sites of several other health technology agencies were also reviewed including the Canadian Agency for Drugs and Technologies in Health (CADTH), ECRI, and the United Kingdom National Institute for Clinical Excellence (NICE). The bibliographies of relevant articles were scanned. Inclusion Criteria English language reports and human studies Any corneal thinning disorder Reports with corneal implants used alone or in conjunction with other interventions Original reports with defined study methodology Reports including standardized measurements on outcome events such as technical success, safety, effectiveness, durability, vision quality of life or patient satisfaction Case reports or case series for complications and adverse events Exclusion Criteria Non-systematic reviews, letters, comments and editorials Reports not involving outcome events such as safety, effectiveness, durability, vision quality or patient satisfaction following an intervention with corneal implants Reports not involving corneal thinning disorders and an intervention with corneal implants Summary of Findings In the MAS evidence review on intrastromal corneal ring implants, 66 reports were identified on the use of implants for management of corneal thinning disorders. Reports varied according to their primary clinical indication, type of corneal implant, and whether or not secondary procedures were used in conjunction with the implants. Implants were reported to manage post LASIK thinning and/or uncorrected refractive error and were also reported as an adjunctive intervention both during and after corneal transplant to manage recurrent thinning and/or uncorrected refractive error. Ten pre-post cohort longitudinal follow-up studies were identified